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Search of human proteins with 46249351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46249351 homer 2 isoform 2 [Homo sapiens]
(354 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46249351 homer 2 isoform 2 [Homo sapiens] 695 0.0
gi|46249349 homer 2 isoform 1 [Homo sapiens] 665 0.0
gi|110349797 homer 2 isoform 4 [Homo sapiens] 472 e-133
gi|110349794 homer 2 isoform 3 [Homo sapiens] 442 e-124
gi|4759198 homer 1 [Homo sapiens] 354 6e-98
gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1 [... 297 1e-80
gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1 [... 297 1e-80
gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2 [... 293 1e-79
gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3 [... 249 3e-66
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 69 5e-12
gi|56549694 enabled homolog isoform a [Homo sapiens] 68 1e-11
gi|39930375 enabled homolog isoform b [Homo sapiens] 68 1e-11
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 65 1e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 65 1e-10
gi|16262452 cingulin [Homo sapiens] 63 3e-10
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 61 1e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 60 4e-09
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 60 4e-09
gi|110347443 TATA element modulatory factor 1 [Homo sapiens] 59 5e-09
gi|38044112 restin isoform b [Homo sapiens] 59 5e-09
gi|4506751 restin isoform a [Homo sapiens] 59 5e-09
gi|71061468 centromere protein E [Homo sapiens] 59 5e-09
gi|219842214 protein phosphatase 1, regulatory (inhibitor) subun... 59 7e-09
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 59 7e-09
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 59 7e-09
gi|32698688 citron [Homo sapiens] 59 9e-09
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 58 1e-08
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 57 2e-08
gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sa... 57 3e-08
gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sap... 57 3e-08
>gi|46249351 homer 2 isoform 2 [Homo sapiens]
Length = 354
Score = 695 bits (1793), Expect = 0.0
Identities = 354/354 (100%), Positives = 354/354 (100%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 180
IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV
Sbjct: 121 IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 180
Query: 181 KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 240
KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN
Sbjct: 181 KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 240
Query: 241 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 300
REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN
Sbjct: 241 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 300
Query: 301 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 354
LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 301 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 354
>gi|46249349 homer 2 isoform 1 [Homo sapiens]
Length = 343
Score = 665 bits (1716), Expect = 0.0
Identities = 343/354 (96%), Positives = 343/354 (96%), Gaps = 11/354 (3%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 180
IETSSNHSQ ASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV
Sbjct: 121 IETSSNHSQ-----------ASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 169
Query: 181 KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 240
KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN
Sbjct: 170 KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 229
Query: 241 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 300
REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN
Sbjct: 230 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 289
Query: 301 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 354
LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 290 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 343
>gi|110349797 homer 2 isoform 4 [Homo sapiens]
Length = 299
Score = 472 bits (1214), Expect = e-133
Identities = 258/354 (72%), Positives = 277/354 (78%), Gaps = 55/354 (15%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 180
IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV
Sbjct: 121 IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 180
Query: 181 KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 240
K EI + +++N +L+ +I+ELE +
Sbjct: 181 KN-EINRE------------------------------KEKNTQLKRRIEELEAEL---- 205
Query: 241 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 300
+EK T+LK +LR++ + L + E + + + E RDNQN
Sbjct: 206 --REKETELK--------DLRKQSEIIPQLMSECEYVSEKLEAAE----------RDNQN 245
Query: 301 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 354
LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 246 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 299
>gi|110349794 homer 2 isoform 3 [Homo sapiens]
Length = 288
Score = 442 bits (1137), Expect = e-124
Identities = 247/354 (69%), Positives = 266/354 (75%), Gaps = 66/354 (18%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 180
IETSSNHS QASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV
Sbjct: 121 IETSSNHS-----------QASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 169
Query: 181 KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 240
K EI + +++N +L+ +I+ELE +
Sbjct: 170 KN-EINRE------------------------------KEKNTQLKRRIEELEAEL---- 194
Query: 241 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 300
+EK T+LK +LR++ + L + E + + + E RDNQN
Sbjct: 195 --REKETELK--------DLRKQSEIIPQLMSECEYVSEKLEAAE----------RDNQN 234
Query: 301 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 354
LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 235 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 288
>gi|4759198 homer 1 [Homo sapiens]
Length = 354
Score = 354 bits (909), Expect = 6e-98
Identities = 186/351 (52%), Positives = 252/351 (71%), Gaps = 2/351 (0%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIF+TRAHVFQIDPNTKKNW+P SK AVTVSYFYD TRN YRIIS+DG+K IINST
Sbjct: 1 MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTV+GLGFSSE L+KFAEKFQE KEAA++AK+K+QEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEK 120
Query: 121 IETSSNHSQES-GRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAAN 179
+E +S SQES G + S S+NGTDDE+ N+ ++E + + + S+A
Sbjct: 121 MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDV-TQNSEPRAEPTQNALPFSHSSAI 179
Query: 180 VKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEI 239
K WE EL TL+ +NA+LT AL ES A+V+QWK+Q + ++E +RL ++ ELE S+
Sbjct: 180 SKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQA 239
Query: 240 NREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQ 299
N T+L + I+ELE L+ KE E++ L+++ + +L + + +++KL+ E N+
Sbjct: 240 NAVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNK 299
Query: 300 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 350
+LE ++ L+ +E+S+ Q + LK+ LE+LDGKI +L + R L+KL
Sbjct: 300 DLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKL 350
>gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
Length = 361
Score = 297 bits (760), Expect = 1e-80
Identities = 161/352 (45%), Positives = 236/352 (67%), Gaps = 5/352 (1%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
Query: 123 TSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKK 182
+S + + P S S+ NG +EK + A+ +E ++LK L++ + +
Sbjct: 126 LTSPALGLASHQVPPSPLVSA-NGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQ 184
Query: 183 WEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINR 241
WE E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
Query: 242 EKEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM--SECEYVSEKLEAAERDN 298
EK + +E+LEA ++ K+ E++ L+ Q+ + + +E E +K++ E N
Sbjct: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRN 304
Query: 299 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 350
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 305 AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
>gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
Length = 361
Score = 297 bits (760), Expect = 1e-80
Identities = 161/352 (45%), Positives = 236/352 (67%), Gaps = 5/352 (1%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
Query: 123 TSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKK 182
+S + + P S S+ NG +EK + A+ +E ++LK L++ + +
Sbjct: 126 LTSPALGLASHQVPPSPLVSA-NGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQ 184
Query: 183 WEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINR 241
WE E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
Query: 242 EKEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM--SECEYVSEKLEAAERDN 298
EK + +E+LEA ++ K+ E++ L+ Q+ + + +E E +K++ E N
Sbjct: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRN 304
Query: 299 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 350
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 305 AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
>gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2
[Homo sapiens]
Length = 358
Score = 293 bits (751), Expect = 1e-79
Identities = 160/350 (45%), Positives = 232/350 (66%), Gaps = 4/350 (1%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
Query: 123 TSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKK 182
+S + + P S S+ NG +EK + A+ +E ++LK L++ + +
Sbjct: 126 LTSPALGLASHQVPPSPLVSA-NGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQ 184
Query: 183 WEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINR 241
WE E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
Query: 242 EKEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 300
EK + +E+LEA ++ K+ E++ L+ Q+ P+ E E + + N
Sbjct: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG-GPREALEAAEREETQQKVQTRNAE 303
Query: 301 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 350
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 304 LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 353
>gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3
[Homo sapiens]
Length = 325
Score = 249 bits (636), Expect = 3e-66
Identities = 144/352 (40%), Positives = 210/352 (59%), Gaps = 41/352 (11%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLT------------------------- 100
Query: 123 TSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKK 182
+ P S S+ NG +EK + A+ +E ++LK L++ + +
Sbjct: 101 -----------QVPPSPLVSA-NGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQ 148
Query: 183 WEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINR 241
WE E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 149 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 208
Query: 242 EKEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM--SECEYVSEKLEAAERDN 298
EK + +E+LEA ++ K+ E++ L+ Q+ + + +E E +K++ E N
Sbjct: 209 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRN 268
Query: 299 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 350
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 269 AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 320
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 69.3 bits (168), Expect = 5e-12
Identities = 72/271 (26%), Positives = 130/271 (47%), Gaps = 43/271 (15%)
Query: 93 EQQLTKFAEKFQEVKEAAK---IAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDD 149
E+ L +F E Q+ + K + + K +E+I +N+ Q+ + N
Sbjct: 1158 ERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETN---- 1213
Query: 150 EKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVE 209
+ E +KLK L+ S+A + + +LQ E A L L ++ ++
Sbjct: 1214 -------------RQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIK 1260
Query: 210 QWKRQFSICRDENDRLRNKIDELEE---QCS-EINREKEKNTQLKRRI--EELEAELREK 263
Q +++ S+ RDE+ LR KI+ELE+ QCS E++ ++ QLK ++ +++E +++
Sbjct: 1261 QVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQY 1320
Query: 264 ETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLE---DKVRSLKTDIE------- 313
E KDL + +II + E E+ + +Q LE ++V L T++E
Sbjct: 1321 ERACKDLNVKEKIIEDMRMTLE---EQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCN 1377
Query: 314 --ESKYRQRHLKVELKSFLEVLDGKIDDLHD 342
E+K QR K E ++ +VL GK+ +L D
Sbjct: 1378 DLETKNNQRSNK-EHENNTDVL-GKLTNLQD 1406
Score = 44.3 bits (103), Expect = 2e-04
Identities = 50/249 (20%), Positives = 110/249 (44%), Gaps = 20/249 (8%)
Query: 98 KFAEKFQEVKEAAKIA--KDKTQEKIETSSNHSQESGRETPSSTQASSVNGTD---DEKA 152
K + Q +KE I K+ T + + +H + + + + +S + +E
Sbjct: 718 KIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETV 777
Query: 153 SHAGPANTHLKSENDKL-KIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQW 211
+ + + SE ++ + L Q KK I + + + + + ++ + A +E
Sbjct: 778 EVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDI 837
Query: 212 KRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLR 271
+ + ++ N+ LR + +E +E+ EKE+ +L ++I + EL E + L
Sbjct: 838 R----VLQENNEGLRAFLLTIE---NELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLS 890
Query: 272 KQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLE 331
K+ + Q+ S + +L + NQ E+K+ L +IE + R + + S ++
Sbjct: 891 KE---VQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETA---TRSITNNV-SQIK 943
Query: 332 VLDGKIDDL 340
++ KID+L
Sbjct: 944 LMHTKIDEL 952
Score = 44.3 bits (103), Expect = 2e-04
Identities = 44/184 (23%), Positives = 79/184 (42%), Gaps = 19/184 (10%)
Query: 163 KSENDKLKIALTQSAANV-KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 221
K EN++LK ++ ++ K+ E +Q L+E L V + KR S
Sbjct: 1056 KDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQG 1115
Query: 222 NDRLRNKIDELEE-------QCS-------EINREKEKNTQLKRRIEELEAELREKETEL 267
+ KI ELE +CS +I ++ +L+R ++E + L++
Sbjct: 1116 VTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNT 1175
Query: 268 KDLR----KQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLK 323
KDL K E I QL + + + L+ E + + + LK ++ S R ++LK
Sbjct: 1176 KDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK 1235
Query: 324 VELK 327
+L+
Sbjct: 1236 ADLQ 1239
Score = 38.5 bits (88), Expect = 0.009
Identities = 31/131 (23%), Positives = 61/131 (46%), Gaps = 26/131 (19%)
Query: 220 DENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ 279
+ + + I+ + E+C EI + K + +IEELE ++ + + E+K
Sbjct: 1008 NRENSFHSSIEAIWEECKEIVKASSKKSH---QIEELEQQIEKLQAEVKG---------- 1054
Query: 280 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDD 339
Y E E++++N +D ++ +T I++ LK EL+ LD +I
Sbjct: 1055 ------YKDENNRLKEKEHKNQDDLLKEKETLIQQ-------LKEELQEKNVTLDVQIQH 1101
Query: 340 LHDFRRGLSKL 350
+ + +R LS+L
Sbjct: 1102 VVEGKRALSEL 1112
Score = 38.1 bits (87), Expect = 0.012
Identities = 43/195 (22%), Positives = 88/195 (45%), Gaps = 29/195 (14%)
Query: 166 NDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRL 225
N K++ A+ Q K ++ + + + R+T QE VEQ + +E +RL
Sbjct: 1310 NQKVEEAIQQYERACKDLNVKEKIIEDM--RMTLEEQEQT-QVEQ-DQVLEAKLEEVERL 1365
Query: 226 RNKIDELEEQCSEI--------NREKEKNTQLKRRIEELEAELREKETELKDLRKQSEII 277
++++ +E+C+++ N+E E NT + ++ L+ EL+E E + RK
Sbjct: 1366 ATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRK----- 1420
Query: 278 PQLMSECEYVSEK--LEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG 335
+++ EK L ++ +N+ +K + E ++Q++ E++ L
Sbjct: 1421 -------KWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQN---EMEILTAQLTE 1470
Query: 336 KIDDLHDFRRGLSKL 350
K DL +R +L
Sbjct: 1471 KDSDLQKWREERDQL 1485
Score = 37.4 bits (85), Expect = 0.021
Identities = 35/163 (21%), Positives = 77/163 (47%), Gaps = 9/163 (5%)
Query: 183 WEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINRE 242
WE E + + +++++ + ++E +E+ + + +DEN+RL+ K E ++ +
Sbjct: 1021 WE-ECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEK-----EHKNQDDLL 1074
Query: 243 KEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAER--DNQN 300
KEK T +++ EEL+ + + +++ + + + +L K++ E + Q
Sbjct: 1075 KEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQK 1134
Query: 301 LE-DKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHD 342
+E L+ DI E + L+ LK F E L + + D
Sbjct: 1135 VECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKD 1177
Score = 30.0 bits (66), Expect = 3.3
Identities = 33/140 (23%), Positives = 59/140 (42%), Gaps = 18/140 (12%)
Query: 199 TALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKE-----------KNT 247
T LQE E +R+ +I +D L K D EE +I K K
Sbjct: 623 TLLQEREILEENAERRLAIFKD----LVGKCDTREEAAKDICATKVETEEATACLELKFN 678
Query: 248 QLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRS 307
Q+K + + + EL + + ELK +S+ L+ E E ++K+ + + L + +
Sbjct: 679 QIKAELAKTKGELIKTKEELKKRENESD---SLIQELETSNKKIITQNQRIKELINIIDQ 735
Query: 308 LKTDIEESKYRQRHLKVELK 327
+ I E + + H++ K
Sbjct: 736 KEDTINEFQNLKSHMENTFK 755
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 68.2 bits (165), Expect = 1e-11
Identities = 70/284 (24%), Positives = 113/284 (39%), Gaps = 44/284 (15%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPA--SKQAVTVSYFYDVTRNSYRIIS--VDGAKVI 56
M EQ I RA V D KK W+PA S V ++ N++R++ + +V+
Sbjct: 1 MSEQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVV 59
Query: 57 INSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEA------- 109
IN I + + + +Q F QW D+R V+GL F S++ FA E
Sbjct: 60 INCAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEVLNSQETG 117
Query: 110 -----------AKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPA 158
A++ +QE++E QE R+ + + E+
Sbjct: 118 PTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLE 177
Query: 159 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 218
L+ E L Q ++ E E Q E RL E+ +RQ +
Sbjct: 178 RERLERER------LEQEQLERERQERERQERLERQERLERQ--------ERLERQERLD 223
Query: 219 RDENDRL-RNKIDELEEQCSEINREKEKNTQLKRRIEELEAELR 261
R+ +R R +++ LE + +E+E+ QL+R E E E R
Sbjct: 224 RERQERQERERLERLERE----RQERERQEQLEREQLEWERERR 263
Score = 30.4 bits (67), Expect = 2.5
Identities = 30/108 (27%), Positives = 57/108 (52%), Gaps = 6/108 (5%)
Query: 219 RDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIP 278
++E + R ++ E + Q E+ RE+ + +++R E LE E E+E L+ R + E +
Sbjct: 137 QEELEIQRRQLQEQQRQ-KELERERLERERMER--ERLERERLERE-RLERERLEQEQLE 192
Query: 279 QLMSECEYVSEKLEAAER-DNQNLEDKVRSLKTDIEESKYRQRHLKVE 325
+ E E E+LE ER + Q ++ L + +E + R+R ++E
Sbjct: 193 RERQERER-QERLERQERLERQERLERQERLDRERQERQERERLERLE 239
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 68.2 bits (165), Expect = 1e-11
Identities = 70/284 (24%), Positives = 113/284 (39%), Gaps = 44/284 (15%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPA--SKQAVTVSYFYDVTRNSYRIIS--VDGAKVI 56
M EQ I RA V D KK W+PA S V ++ N++R++ + +V+
Sbjct: 1 MSEQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVV 59
Query: 57 INSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEA------- 109
IN I + + + +Q F QW D+R V+GL F S++ FA E
Sbjct: 60 INCAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEVLNSQETG 117
Query: 110 -----------AKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPA 158
A++ +QE++E QE R+ + + E+
Sbjct: 118 PTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLE 177
Query: 159 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 218
L+ E L Q ++ E E Q E RL E+ +RQ +
Sbjct: 178 RERLERER------LEQEQLERERQERERQERLERQERLERQ--------ERLERQERLD 223
Query: 219 RDENDRL-RNKIDELEEQCSEINREKEKNTQLKRRIEELEAELR 261
R+ +R R +++ LE + +E+E+ QL+R E E E R
Sbjct: 224 RERQERQERERLERLERE----RQERERQEQLEREQLEWERERR 263
Score = 30.4 bits (67), Expect = 2.5
Identities = 30/108 (27%), Positives = 57/108 (52%), Gaps = 6/108 (5%)
Query: 219 RDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIP 278
++E + R ++ E + Q E+ RE+ + +++R E LE E E+E L+ R + E +
Sbjct: 137 QEELEIQRRQLQEQQRQ-KELERERLERERMER--ERLERERLERE-RLERERLEQEQLE 192
Query: 279 QLMSECEYVSEKLEAAER-DNQNLEDKVRSLKTDIEESKYRQRHLKVE 325
+ E E E+LE ER + Q ++ L + +E + R+R ++E
Sbjct: 193 RERQERER-QERLERQERLERQERLERQERLDRERQERQERERLERLE 239
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 64.7 bits (156), Expect = 1e-10
Identities = 58/244 (23%), Positives = 113/244 (46%), Gaps = 15/244 (6%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKT--QEKIETSSNHSQESGRETPSSTQASSVNGTDDE 150
EQ+ ++ + +++K+ K+ T E +E ++ E E + ++
Sbjct: 662 EQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM--- 718
Query: 151 KASHAGPANTHLKSENDKLKIALTQSAANVKKWE---IELQTLRESNARLTTALQESAAS 207
K + N L+SE ++LK L A+ KK E + Q L N RL L+ S
Sbjct: 719 KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 208 VEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETEL 267
++Q + + EN L+ ++EL+ + + +++N L++ +LE + ++ E E
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 268 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 327
K LR+Q+EI + E + K+ E++N+ L ++ K ES R + L+ E K
Sbjct: 839 KRLRQQAEIKDTTLEE---NNVKIGNLEKENKTLSKEIGIYK----ESCVRLKELEKENK 891
Query: 328 SFLE 331
++
Sbjct: 892 ELVK 895
Score = 52.0 bits (123), Expect = 8e-07
Identities = 53/278 (19%), Positives = 128/278 (46%), Gaps = 33/278 (11%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
EQ+ + +++ ++I+ + + IE + ES +ET S +K
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
Query: 153 SHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTT----ALQESAASV 208
H K + ++ + L +++K E EL + +N ++T AL++ + +
Sbjct: 617 LE------HYKEKGERAE-ELENELHHLEK-ENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 209 EQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIE----------ELEA 258
E+ R+ D L +++ LE++ S+++ E+N +L+R +E +L+
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLD---EENLELRRNVESLKCASMKMAQLQL 725
Query: 259 ELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLE-------DKVRSLKTD 311
E +E E+E + L+K E++ + E + + + +NQ L+ K++ L+++
Sbjct: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
Query: 312 IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSK 349
+++ + + L+ L+ L++ +++ L + L +
Sbjct: 786 LQDLEMENQTLQKNLEE-LKISSKRLEQLEKENKSLEQ 822
Score = 48.1 bits (113), Expect = 1e-05
Identities = 41/173 (23%), Positives = 86/173 (49%), Gaps = 25/173 (14%)
Query: 176 SAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELE-- 233
+++ + K E+E Q+L ++ L T + SVE + EN RL K++ LE
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVD----SVEGNASKILKMEKENQRLSKKVEILENE 513
Query: 234 --------EQCSEINRE--KEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSE 283
+ C ++++ KEK QL++ IE L E ++K L +++E + Q +S
Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEK-AQLEKTIETLR---ENSERQIKILEQENEHLNQTVSS 569
Query: 284 CEYVSE-----KLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLE 331
S+ +++ E++N+ L + ++ + + + ++ +R +K EL+ + E
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Score = 46.6 bits (109), Expect = 3e-05
Identities = 79/341 (23%), Positives = 139/341 (40%), Gaps = 82/341 (24%)
Query: 64 NMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVK---EAAKIAKDK-TQE 119
N + ++K + DS N F L S E++ ++ E+ E++ E+ K A K Q
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLE-SLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 120 KIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAAN 179
++E S++ + +S T+ + S+ G L EN +L+ L S
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG-----LDIENQRLQKTLENSNKK 778
Query: 180 VKKWEIELQTLRESNARLTTALQE---SAASVEQWKRQFSICRDENDRLRNKIDELEEQC 236
+++ E ELQ L N L L+E S+ +EQ +++ E +L +LE++
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 237 SEINREKE-KNTQLKR---RIEELEAE-----------------LREKETELKDLRKQSE 275
+ ++ E K+T L+ +I LE E L+E E E K+L K++
Sbjct: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
Query: 276 I-IPQLMSECE-YVSEKLEAAERDN----------------------------------- 298
I I L++ E VSEKL+ + +N
Sbjct: 899 IDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLE 958
Query: 299 -----------QNLEDKVRSLKTDIEESKYRQRHLKVELKS 328
+ E+K+ +L+ +EES + L+ ELK+
Sbjct: 959 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
Score = 41.2 bits (95), Expect = 0.001
Identities = 36/156 (23%), Positives = 74/156 (47%), Gaps = 12/156 (7%)
Query: 192 ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQL-- 249
ES L+ L ++ A + + +++ ++ ++L + ELE+ E+ R +++N L
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELE---EKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 250 -----KRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDK 304
+ +EL+A LREK + L + + + + E+ ++E + DNQ L +
Sbjct: 301 DARSARMYRDELDA-LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 305 VRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 340
L+ +E ++ R L K L+ L K+ D+
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQ-LKAKLHDM 394
Score = 39.7 bits (91), Expect = 0.004
Identities = 40/173 (23%), Positives = 75/173 (43%), Gaps = 18/173 (10%)
Query: 173 LTQSAANVKKWEIELQTLRESNARL------TTALQESAASVEQWKRQFSICRDENDRLR 226
L A + + + EL LRE R+ + +E +E +K + +++N L
Sbjct: 298 LLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 227 NKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEII--------- 277
LE+Q +K +L++ +L+A+L + E E RK+ E +
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM 417
Query: 278 --PQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKS 328
Q M E ++ +LE R ++ E +SL ++ E R LK+E+++
Sbjct: 418 AQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELT-SSRLLKLEMEN 469
Score = 39.3 bits (90), Expect = 0.005
Identities = 43/231 (18%), Positives = 94/231 (40%), Gaps = 38/231 (16%)
Query: 105 EVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKS 164
++K + +D EK++T Q+ + T G + E+ H +
Sbjct: 900 DIKTLVTLREDLVSEKLKT-----QQMNNDLEKLTHELEKIGLNKERLLH-----DEQST 949
Query: 165 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 224
++ + K+ ++ + +KK L+ E A L L+ES +Q +++ + +
Sbjct: 950 DDSRYKLLESKLESTLKK---SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006
Query: 225 LRNKIDE----------------LEEQCSEINRE----KEKNTQLKRRIEELEAELREKE 264
L+ + DE E + E RE K++ +++R L+AE + +
Sbjct: 1007 LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1066
Query: 265 TELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEES 315
T+LK L Q+ + + + ++ + + QN + ++ K +E S
Sbjct: 1067 TQLKQLETQNNNL-----QAQILALQRQTVSLQEQNTTLQTQNAKLQVENS 1112
Score = 35.8 bits (81), Expect = 0.060
Identities = 48/205 (23%), Positives = 89/205 (43%), Gaps = 43/205 (20%)
Query: 172 ALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE 231
AL + A V K E E+ +E RL ++ A VE+ K + + L ++++
Sbjct: 314 ALREKAVRVDKLESEVSRYKE---RLHD-IEFYKARVEELKEDNQVLLETKTMLEDQLEG 369
Query: 232 LEEQCSEINREKEKNTQLKRRIEELEAE----------LREKETELKDLRKQS------- 274
+ +++ +++N QLK ++ ++E E L E+ L+ +KQS
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 275 ----EIIPQL--MSEC----------EYVSEKLEAAERDNQNLEDKVRSLKTDIEESK-Y 317
E I + +SE E S +L E +NQ+L V L+T ++ +
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 318 RQRHLKVE-----LKSFLEVLDGKI 337
+ LK+E L +E+L+ +I
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEI 514
Score = 35.0 bits (79), Expect = 0.10
Identities = 53/278 (19%), Positives = 110/278 (39%), Gaps = 50/278 (17%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKAS 153
+QL K + ++ E +++ KDK Q + E Q ++T + + E +
Sbjct: 811 EQLEKENKSLEQ--ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 154 HAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTL---RESNARLTTALQESAASVEQ 210
+ + K +LK ++ VK+ I+++TL RE Q+ +E+
Sbjct: 869 LSKEIGIY-KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Query: 211 WKRQFS--------ICRDENDR-------LRNKIDELEEQCSEINREKEKNTQLKRRIEE 255
+ + DE L +K++ ++ EI ++EK L+ R+EE
Sbjct: 928 LTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI--KEEKIAALEARLEE 985
Query: 256 LEAELREKETELKDLRKQSEIIPQLMSECEY---------------------------VS 288
++ ELK ++K E + Q E V
Sbjct: 986 STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1045
Query: 289 EKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 326
++L ER+N L+ + ++LKT +++ + + +L+ ++
Sbjct: 1046 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083
Score = 33.9 bits (76), Expect = 0.23
Identities = 39/172 (22%), Positives = 75/172 (43%), Gaps = 21/172 (12%)
Query: 162 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 221
L END+L +Q E + L+ + L + L S + + +FS
Sbjct: 1243 LCGENDRLNHTYSQLLK-------ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS----- 1290
Query: 222 NDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETEL----KDLRKQSEII 277
+L+ + +L+ +++N + E +QLK +EE L ++ L + L +Q+
Sbjct: 1291 --KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMES 1348
Query: 278 PQL--MSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 327
L + + +Y+ +KL R + LE+K+ + S R+R + LK
Sbjct: 1349 KDLFHVEQRQYI-DKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK 1399
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 64.7 bits (156), Expect = 1e-10
Identities = 58/244 (23%), Positives = 113/244 (46%), Gaps = 15/244 (6%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKT--QEKIETSSNHSQESGRETPSSTQASSVNGTDDE 150
EQ+ ++ + +++K+ K+ T E +E ++ E E + ++
Sbjct: 662 EQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM--- 718
Query: 151 KASHAGPANTHLKSENDKLKIALTQSAANVKKWE---IELQTLRESNARLTTALQESAAS 207
K + N L+SE ++LK L A+ KK E + Q L N RL L+ S
Sbjct: 719 KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 208 VEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETEL 267
++Q + + EN L+ ++EL+ + + +++N L++ +LE + ++ E E
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 268 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 327
K LR+Q+EI + E + K+ E++N+ L ++ K ES R + L+ E K
Sbjct: 839 KRLRQQAEIKDTTLEE---NNVKIGNLEKENKTLSKEIGIYK----ESCVRLKELEKENK 891
Query: 328 SFLE 331
++
Sbjct: 892 ELVK 895
Score = 52.0 bits (123), Expect = 8e-07
Identities = 53/278 (19%), Positives = 128/278 (46%), Gaps = 33/278 (11%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
EQ+ + +++ ++I+ + + IE + ES +ET S +K
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
Query: 153 SHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTT----ALQESAASV 208
H K + ++ + L +++K E EL + +N ++T AL++ + +
Sbjct: 617 LE------HYKEKGERAE-ELENELHHLEK-ENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 209 EQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIE----------ELEA 258
E+ R+ D L +++ LE++ S+++ E+N +L+R +E +L+
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLD---EENLELRRNVESLKCASMKMAQLQL 725
Query: 259 ELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLE-------DKVRSLKTD 311
E +E E+E + L+K E++ + E + + + +NQ L+ K++ L+++
Sbjct: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
Query: 312 IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSK 349
+++ + + L+ L+ L++ +++ L + L +
Sbjct: 786 LQDLEMENQTLQKNLEE-LKISSKRLEQLEKENKSLEQ 822
Score = 48.1 bits (113), Expect = 1e-05
Identities = 41/173 (23%), Positives = 86/173 (49%), Gaps = 25/173 (14%)
Query: 176 SAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELE-- 233
+++ + K E+E Q+L ++ L T + SVE + EN RL K++ LE
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVD----SVEGNASKILKMEKENQRLSKKVEILENE 513
Query: 234 --------EQCSEINRE--KEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSE 283
+ C ++++ KEK QL++ IE L E ++K L +++E + Q +S
Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEK-AQLEKTIETLR---ENSERQIKILEQENEHLNQTVSS 569
Query: 284 CEYVSE-----KLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLE 331
S+ +++ E++N+ L + ++ + + + ++ +R +K EL+ + E
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Score = 47.0 bits (110), Expect = 3e-05
Identities = 79/340 (23%), Positives = 139/340 (40%), Gaps = 81/340 (23%)
Query: 64 NMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVK---EAAKIAKDK-TQE 119
N + ++K + DS N F L S E++ ++ E+ E++ E+ K A K Q
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLE-SLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 120 KIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAAN 179
++E S++ + +S T+ + S+ G L EN +L+ L S
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG-----LDIENQRLQKTLENSNKK 778
Query: 180 VKKWEIELQTLRESNARLTTALQE---SAASVEQWKRQFSICRDENDRLRNKIDELEEQC 236
+++ E ELQ L N L L+E S+ +EQ +++ E +L +LE++
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 237 SEINREKE-KNTQLKR---RIEELEAE-----------------LREKETELKDLRKQSE 275
+ ++ E K+T L+ +I LE E L+E E E K+L K++
Sbjct: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
Query: 276 I-IPQLMSECE-YVSEKLEAAERDN----------------------------------- 298
I I L++ E VSEKL+ + +N
Sbjct: 899 IDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLES 958
Query: 299 ----------QNLEDKVRSLKTDIEESKYRQRHLKVELKS 328
+ E+K+ +L+ +EES + L+ ELK+
Sbjct: 959 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
Score = 41.2 bits (95), Expect = 0.001
Identities = 36/156 (23%), Positives = 74/156 (47%), Gaps = 12/156 (7%)
Query: 192 ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQL-- 249
ES L+ L ++ A + + +++ ++ ++L + ELE+ E+ R +++N L
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELE---EKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 250 -----KRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDK 304
+ +EL+A LREK + L + + + + E+ ++E + DNQ L +
Sbjct: 301 DARSARMYRDELDA-LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 305 VRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 340
L+ +E ++ R L K L+ L K+ D+
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQ-LKAKLHDM 394
Score = 41.2 bits (95), Expect = 0.001
Identities = 45/231 (19%), Positives = 95/231 (41%), Gaps = 39/231 (16%)
Query: 105 EVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKS 164
++K + +D EK++T Q+ + T G + E+ H +S
Sbjct: 900 DIKTLVTLREDLVSEKLKT-----QQMNNDLEKLTHELEKIGLNKERLLHDE------QS 948
Query: 165 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 224
+D+ K+ ++ + +KK L+ E A L L+ES +Q +++ + +
Sbjct: 949 TDDRYKLLESKLESTLKK---SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1005
Query: 225 LRNKIDE----------------LEEQCSEINRE----KEKNTQLKRRIEELEAELREKE 264
L+ + DE E + E RE K++ +++R L+AE + +
Sbjct: 1006 LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1065
Query: 265 TELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEES 315
T+LK L Q+ + + + ++ + + QN + ++ K +E S
Sbjct: 1066 TQLKQLETQNNNL-----QAQILALQRQTVSLQEQNTTLQTQNAKLQVENS 1111
Score = 39.7 bits (91), Expect = 0.004
Identities = 40/173 (23%), Positives = 75/173 (43%), Gaps = 18/173 (10%)
Query: 173 LTQSAANVKKWEIELQTLRESNARL------TTALQESAASVEQWKRQFSICRDENDRLR 226
L A + + + EL LRE R+ + +E +E +K + +++N L
Sbjct: 298 LLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 227 NKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEII--------- 277
LE+Q +K +L++ +L+A+L + E E RK+ E +
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM 417
Query: 278 --PQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKS 328
Q M E ++ +LE R ++ E +SL ++ E R LK+E+++
Sbjct: 418 AQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELT-SSRLLKLEMEN 469
Score = 37.7 bits (86), Expect = 0.016
Identities = 52/277 (18%), Positives = 109/277 (39%), Gaps = 49/277 (17%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKAS 153
+QL K + ++ E +++ KDK Q + E Q ++T + + E +
Sbjct: 811 EQLEKENKSLEQ--ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 154 HAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTL-----------------RESNAR 196
+ + K +LK ++ VK+ I+++TL +
Sbjct: 869 LSKEIGIY-KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Query: 197 LTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL 256
LT L++ + E+ D L +K++ ++ EI ++EK L+ R+EE
Sbjct: 928 LTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEI--KEEKIAALEARLEES 985
Query: 257 EAELREKETELKDLRKQSEIIPQLMSECEY---------------------------VSE 289
++ ELK ++K E + Q E V +
Sbjct: 986 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD 1045
Query: 290 KLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 326
+L ER+N L+ + ++LKT +++ + + +L+ ++
Sbjct: 1046 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1082
Score = 35.8 bits (81), Expect = 0.060
Identities = 48/205 (23%), Positives = 89/205 (43%), Gaps = 43/205 (20%)
Query: 172 ALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE 231
AL + A V K E E+ +E RL ++ A VE+ K + + L ++++
Sbjct: 314 ALREKAVRVDKLESEVSRYKE---RLHD-IEFYKARVEELKEDNQVLLETKTMLEDQLEG 369
Query: 232 LEEQCSEINREKEKNTQLKRRIEELEAE----------LREKETELKDLRKQS------- 274
+ +++ +++N QLK ++ ++E E L E+ L+ +KQS
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 275 ----EIIPQL--MSEC----------EYVSEKLEAAERDNQNLEDKVRSLKTDIEESK-Y 317
E I + +SE E S +L E +NQ+L V L+T ++ +
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 318 RQRHLKVE-----LKSFLEVLDGKI 337
+ LK+E L +E+L+ +I
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEI 514
Score = 33.9 bits (76), Expect = 0.23
Identities = 39/172 (22%), Positives = 75/172 (43%), Gaps = 21/172 (12%)
Query: 162 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 221
L END+L +Q E + L+ + L + L S + + +FS
Sbjct: 1242 LCGENDRLNHTYSQLLK-------ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS----- 1289
Query: 222 NDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETEL----KDLRKQSEII 277
+L+ + +L+ +++N + E +QLK +EE L ++ L + L +Q+
Sbjct: 1290 --KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMES 1347
Query: 278 PQL--MSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 327
L + + +Y+ +KL R + LE+K+ + S R+R + LK
Sbjct: 1348 KDLFHVEQRQYI-DKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK 1398
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 63.2 bits (152), Expect = 3e-10
Identities = 72/263 (27%), Positives = 124/263 (47%), Gaps = 29/263 (11%)
Query: 93 EQQLTKFAEKFQ-EVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEK 151
+ QL + EK + EV +A + AKD E +TS S+ E QA +
Sbjct: 873 QAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQD-EIQRLRQAL--------Q 923
Query: 152 ASHAGPANTHLKSENDKLKI-ALTQSAANVKKWEIE----LQTLRESNARLTTALQESAA 206
AS A L E ++ L Q A N K+ + + L+ L E +RL T L E
Sbjct: 924 ASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKN 983
Query: 207 SVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETE 266
+VE + + RD+ D+LR ++ ++E+ + + E +K L+R+ ++L+ L E
Sbjct: 984 TVELLTDRVNRGRDQVDQLRTEL--MQERSARQDLECDK-ISLERQNKDLKTRLASSE-- 1038
Query: 267 LKDLRKQSEIIPQLMSECEYVSEKLEAAERD-------NQNLEDKVRSLKTDIEESKYRQ 319
+K S + QL S+ + + E+L+A ER+ N+ LE KV+ L IE+ +
Sbjct: 1039 --GFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHV 1096
Query: 320 RHLKVELKSFLEVLDGKIDDLHD 342
K +L ++ L ++D+ +
Sbjct: 1097 NDQKDQLSLRVKALKRQVDEAEE 1119
Score = 45.8 bits (107), Expect = 6e-05
Identities = 70/307 (22%), Positives = 129/307 (42%), Gaps = 54/307 (17%)
Query: 69 KTSQKFGQWA--------DSRANT--VFGLGFSSEQQLTKFAEKFQ----EVKEAAKIAK 114
+TS++ G W D RA + L E+ + EK + E+++A A
Sbjct: 563 ETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAG 622
Query: 115 DKTQ-EKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIAL 173
D Q E ++ +QE +E + Q+ V G ++ A ++++ + L
Sbjct: 623 DTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGR---EL 679
Query: 174 TQSAANVKKWEIELQTLRE-----SNARLT-----TALQESAASVEQWKRQFSICRDEND 223
+ ++K LQ LR+ S A++ T L + A+VE R+ ++END
Sbjct: 680 EEQNLQLQK---TLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRE---TQEEND 733
Query: 224 RLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSE 283
R +I LE+Q E + E +EA LR+K + +L +E
Sbjct: 734 EFRRRILGLEQQLKETRGLVDGG-------EAVEARLRDK-------------LQRLEAE 773
Query: 284 CEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDF 343
+ + E L A++ + +L R+L+ +EE++ L E ++ L+ +
Sbjct: 774 KQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVL 833
Query: 344 RRGLSKL 350
RRG ++L
Sbjct: 834 RRGKAEL 840
Score = 38.1 bits (87), Expect = 0.012
Identities = 52/243 (21%), Positives = 100/243 (41%), Gaps = 55/243 (22%)
Query: 79 DSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSS 138
D RA + GL E+++++ + E K ++ D+ Q T
Sbjct: 958 DDRARQLKGL----EEKVSRLETELDEEKNTVELLTDRVNR------GRDQVDQLRTELM 1007
Query: 139 TQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQS------AANVKKWEIELQTLRE 192
+ S+ + +K S L+ +N LK L S +A++ + E + Q L+E
Sbjct: 1008 QERSARQDLECDKIS--------LERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQE 1059
Query: 193 ---SNARLTTALQESAASVEQWKRQFSI-CRDENDRLRNKIDELEEQCSEINREKEKNTQ 248
+ R T LQ + +E+ ++ SI DE + ++ D+L +
Sbjct: 1060 RLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVK----------A 1109
Query: 249 LKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL 308
LKR+++E E E+ L LRK+++ ++E N+ L+ +++SL
Sbjct: 1110 LKRQVDEAEEEIE----RLDGLRKKAQ-------------REVEEQHEVNEQLQARIKSL 1152
Query: 309 KTD 311
+ D
Sbjct: 1153 EKD 1155
Score = 36.6 bits (83), Expect = 0.035
Identities = 39/192 (20%), Positives = 83/192 (43%), Gaps = 28/192 (14%)
Query: 149 DEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASV 208
D++ H + + ++L+ ++ + + E E Q + L L+E++
Sbjct: 512 DQEVEHV---RQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEET 568
Query: 209 EQWKRQFS-------ICRDENDRLRNKIDELEEQCSE----INREKEK---NTQLKRRIE 254
W+ F + E +LR + +E+EE+ E + RE E+ + R++E
Sbjct: 569 GHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVE 628
Query: 255 ELEAELREKETELKDL---RKQSEI--------IPQLMSECEYVSEKLEAAERDNQNLED 303
L+ EL + ELK+L R+ E+ + + ++ +++ E N L+
Sbjct: 629 VLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQK 688
Query: 304 KVRSLKTDIEES 315
++ L+ D EE+
Sbjct: 689 TLQQLRQDCEEA 700
Score = 36.2 bits (82), Expect = 0.046
Identities = 36/172 (20%), Positives = 74/172 (43%), Gaps = 24/172 (13%)
Query: 186 ELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK 245
ELQ + + L+ S +E RQ +E RL+ ++ + + + N+E +
Sbjct: 370 ELQRKLDEEVKKRQKLEPSQVGLE---RQLEEKTEECSRLQELLERRKGEAQQSNKELQN 426
Query: 246 NTQL-----------KRRIEELEAELRE-------KETELKDLRKQSEIIPQLMSECEYV 287
+L + ++ EL+ +L+ KE LKDL + E++ +++ + V
Sbjct: 427 MKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV 486
Query: 288 SEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDD 339
E+L ER+ L+ +LK ++ H++ + + E L + D
Sbjct: 487 EEQLRLRERELTALKG---ALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQD 535
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 61.2 bits (147), Expect = 1e-09
Identities = 61/258 (23%), Positives = 112/258 (43%), Gaps = 34/258 (13%)
Query: 95 QLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSS-------TQASSVNGT 147
Q+ + E Q VK+ + K +E S S+ +GR P+ + S +
Sbjct: 1076 QIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ 1135
Query: 148 DDEKASHAGPANTHLKSEN----------DKLKIALTQSAANVKKWEIELQTLRESNARL 197
++ A L++E + L+ L + A + + L + + A
Sbjct: 1136 CQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAF 1195
Query: 198 TTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINR---EKEKNTQLKRRIE 254
T +Q+ + + ++WK Q + R E +R + I LEE+ S +NR EKE ++ +R+
Sbjct: 1196 RTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLV 1255
Query: 255 ELEAELREK-ETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIE 313
E+E +K E L+ + + E S AAER + L ++V+SL+ + E
Sbjct: 1256 MAESEKSQKLEERLR------------LLQAETASNSARAAERSSA-LREEVQSLREEAE 1302
Query: 314 ESKYRQRHLKVELKSFLE 331
+ + +L+ EL S E
Sbjct: 1303 KQRVASENLRQELTSQAE 1320
Score = 53.1 bits (126), Expect = 4e-07
Identities = 55/260 (21%), Positives = 117/260 (45%), Gaps = 19/260 (7%)
Query: 87 GLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNG 146
GL ++++ + A+ Q+ ++A++ + + E++ +S ++ +E +A
Sbjct: 523 GLKQQAKEKQAQLAQTLQQQEQASQGLRHQV-EQLSSSLKQKEQQLKEVAEKQEA----- 576
Query: 147 TDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAA 206
T + A A ++ + AL Q A K+ +L+ L++ A +
Sbjct: 577 TRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636
Query: 207 SVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETE 266
SV Q +R E L K++EL+ C E R+++ Q + + ELE +LR ++ +
Sbjct: 637 SVTQAQR-------EKAELSRKVEELQA-CVETARQEQHEAQAQ--VAELELQLRSEQQK 686
Query: 267 LKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 326
+ + ++ QL + + + E L+ + +LE++ R +EE + LK E
Sbjct: 687 ATEKERVAQEKDQLQEQLQALKESLKVTK---GSLEEEKRRAADALEEQQRCISELKAET 743
Query: 327 KSFLEVLDGKIDDLHDFRRG 346
+S +E + +L + R G
Sbjct: 744 RSLVEQHKRERKELEEERAG 763
Score = 50.1 bits (118), Expect = 3e-06
Identities = 54/257 (21%), Positives = 107/257 (41%), Gaps = 28/257 (10%)
Query: 86 FGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVN 145
F L L + E F + E++ S+ ++ R ASS +
Sbjct: 133 FVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSS 192
Query: 146 GTDDEKASHAGPANTHLKS---ENDKLKIALTQSAANVKKWEIEL----QTLRESNARLT 198
G + S A P L++ + +LK L +N + E+EL + L E +A++
Sbjct: 193 GNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIA 252
Query: 199 ---------TALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREK------ 243
L E A+ ++ RD+N+ L ++ E +QC ++ EK
Sbjct: 253 MMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRK 312
Query: 244 -----EKNTQLKRRIEELEAELREKETELKDLRKQ-SEIIPQLMSECEYVSEKLEAAERD 297
E+N L ++ E + L++ + L +L ++ S+ + + + + ++L AA +D
Sbjct: 313 INQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQD 372
Query: 298 NQNLEDKVRSLKTDIEE 314
+ LE+K L+ + +
Sbjct: 373 KKCLEEKNEILQGKLSQ 389
Score = 46.6 bits (109), Expect = 3e-05
Identities = 49/192 (25%), Positives = 87/192 (45%), Gaps = 41/192 (21%)
Query: 162 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKR---QFSIC 218
L EN L L + A+++++ + L L E +++ T E A +E+ Q C
Sbjct: 316 LSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC 375
Query: 219 RDE-NDRLRNKIDELEEQCSEI--NREKEK-----------------------NTQLKRR 252
+E N+ L+ K+ +LEE S++ N +EK NTQL+ R
Sbjct: 376 LEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR 435
Query: 253 IEELEAELREKETEL--------KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQ----N 300
+E LE E ++E +L ++ ++ S +I L S +S+ E E+ +Q
Sbjct: 436 VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGAR 495
Query: 301 LEDKVRSLKTDI 312
L +V SL +++
Sbjct: 496 LTAQVASLTSEL 507
Score = 44.3 bits (103), Expect = 2e-04
Identities = 37/171 (21%), Positives = 86/171 (50%), Gaps = 12/171 (7%)
Query: 161 HLKSENDKLKIALTQ---SAANVKKWEIELQTLRESN-ARLTTALQESAASVEQWKRQFS 216
H + E +L +T S +N+ + + EL+ +++ ARLT + + +
Sbjct: 456 HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQ 515
Query: 217 ICRDENDRLRNKIDELEEQCSEINREKEKNTQ-LKRRIEELEAELREKETELKDLRKQSE 275
E L+ + E + Q ++ +++E+ +Q L+ ++E+L + L++KE +LK++ ++ E
Sbjct: 516 QQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE 575
Query: 276 IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 326
Q ++ + AAE +L ++ +LK E+ +++ K+E+
Sbjct: 576 ATRQ-----DHAQQLATAAEEREASLRERDAALKQ--LEALEKEKAAKLEI 619
Score = 44.3 bits (103), Expect = 2e-04
Identities = 55/273 (20%), Positives = 108/273 (39%), Gaps = 36/273 (13%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
E++ E Q+ + A A+D Q + + E R+ QA ++
Sbjct: 610 EKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKV-EELQACVETARQEQHE 668
Query: 153 SHAGPANTHLKSENDKLKIALTQSAANVK-KWEIELQTLRES-----------NARLTTA 200
+ A A L+ +++ K + A K + + +LQ L+ES R A
Sbjct: 669 AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728
Query: 201 LQESAASVEQWKRQFSICRDENDRLRNKIDE-------LEEQCSEINREKEKNTQ-LKRR 252
L+E + + K + +++ R R +++E LE + ++ + T+ L+R
Sbjct: 729 LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE 788
Query: 253 IEELEAELREKETELKDLRKQ-----SEIIPQLMSECEY----------VSEKLEAAERD 297
+ E A E+E + L K+ E +Y + E+ E A ++
Sbjct: 789 LAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848
Query: 298 NQNLEDKVRSLKTDIEESKYRQRHLKVELKSFL 330
Q ++KV +++ E RQ++ EL + L
Sbjct: 849 LQEAKEKVAGIESHSELQISRQQNELAELHANL 881
Score = 41.6 bits (96), Expect = 0.001
Identities = 60/251 (23%), Positives = 111/251 (44%), Gaps = 40/251 (15%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
E +L + EK+ V+E A + D + ++ +Q + RE T A
Sbjct: 1466 EVELDQAREKY--VQELAAVRAD-AETRLAEVQREAQSTARELEVMT------------A 1510
Query: 153 SHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQES--AASVEQ 210
+ G A + E + + + A V++ E+ + + L+ L +S A+ V+Q
Sbjct: 1511 KYEG-AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQ 1569
Query: 211 WK-----RQFSICRDENDRLRNKIDELEEQCSE---------INREKEKN--TQLKRRIE 254
K Q + E RL+ +++EL+ Q S+ + EK K K++ +
Sbjct: 1570 QKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQ 1629
Query: 255 ELEAELREKE---TELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD 311
EL+ +LR E E K+LR ++E +L E + K + AE+ ++L +VRSL+
Sbjct: 1630 ELQEQLRSLEQLQKENKELRAEAE---RLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ 1686
Query: 312 IEESKYRQRHL 322
+ + + R L
Sbjct: 1687 VAHADQQLRDL 1697
Score = 41.2 bits (95), Expect = 0.001
Identities = 34/179 (18%), Positives = 83/179 (46%), Gaps = 10/179 (5%)
Query: 101 EKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANT 160
++FQE ++ ++ + + +E ++ S QAS V + G +
Sbjct: 1524 QRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQ 1583
Query: 161 H----LKSENDKLKIALTQSAANVKKWEIELQTLR---ESNARLTTALQESAASVEQWKR 213
L+++ ++L+ L+Q + ++++++ + ++ + LQE S+EQ ++
Sbjct: 1584 QEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQK 1643
Query: 214 QFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRK 272
+ R E +RL + EL++ + ++ L ++ LEA++ + +L+DL K
Sbjct: 1644 ENKELRAEAERLGH---ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Score = 37.7 bits (86), Expect = 0.016
Identities = 38/186 (20%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 184 EIELQTLRES--------NARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ 235
E+EL RE A T L E + R+ + + + + K+ LEE+
Sbjct: 1466 EVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKV--LEER 1523
Query: 236 CSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEA-- 293
R +E+ +L ++E+LE RE+ ++++L K+ Q + + ++A
Sbjct: 1524 ----QRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQG 1579
Query: 294 --AERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGK---IDDLHDFRRGLS 348
++++ Q L+ ++ L+ + + + H K++++ D K +L + R L
Sbjct: 1580 GESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE 1639
Query: 349 KLGTDN 354
+L +N
Sbjct: 1640 QLQKEN 1645
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 59.7 bits (143), Expect = 4e-09
Identities = 65/283 (22%), Positives = 132/283 (46%), Gaps = 24/283 (8%)
Query: 91 SSEQQLTKFAEK-------FQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPS-STQAS 142
S +Q+LTK E+ F+ + + KI ++ +I+T+ Q+ E + T+ S
Sbjct: 797 SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELS 856
Query: 143 SVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNAR----LT 198
+V + + + + + EN K K A+ K+ + +LQ E+ + L
Sbjct: 857 TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
Query: 199 TALQESAASVEQWKRQFSICRDENDRLRN--KIDELEEQCSE--INREKEKNTQLKRRIE 254
+L++ + Q K + + +++ + +N K +E EEQ + IN K+ + Q K++IE
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
Query: 255 ELEAELRE---KETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD 311
L+ EL+ ++TEL++ +Q + Q E EK+ + + + ++ + L++D
Sbjct: 977 ALQGELKIAVLQKTELENKLQQQ--LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD 1034
Query: 312 IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 354
+ + +LKS E L +DL R +++G N
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNR---NQIGNQN 1074
Score = 56.2 bits (134), Expect = 4e-08
Identities = 59/308 (19%), Positives = 132/308 (42%), Gaps = 54/308 (17%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQES-GRETPSSTQASSVNGTDDEK 151
++Q+T+ EK + E+ K A++ ++++ H + + R T + +N +E
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 152 ASHAGPANTHLKSENDKLKIALTQSAANVKKWEIE---------LQTLRESNARLTTALQ 202
+ +K++ + L A ++A ++ +++ LQ ++ ++TT L
Sbjct: 634 KEKVSQLDIQIKAKTELLLSA--EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD 691
Query: 203 ESAASVE--------------QWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK--- 245
+ A ++ ++K ++ + + L +I +LE E+ KE+
Sbjct: 692 QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQ 751
Query: 246 --------NTQLKRRIEELEAELR-EKE----TELKDLRKQSEIIPQLMSECEYVSEKLE 292
NT L+ R EL +L EKE T L DL+K+SE + + + E+ +
Sbjct: 752 DLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL-DLQKKSEALESIKQKLTKQEEEKQ 810
Query: 293 AAERD-----------NQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLH 341
++D ++ L +++++ T++++ K + L EL + + L D L
Sbjct: 811 ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870
Query: 342 DFRRGLSK 349
+ + K
Sbjct: 871 NSKSEFEK 878
Score = 53.1 bits (126), Expect = 4e-07
Identities = 62/260 (23%), Positives = 127/260 (48%), Gaps = 37/260 (14%)
Query: 95 QLTKFAEKFQE--VKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
Q T+ K Q+ + A ++A +K EKI N+ ++S +ET Q S G + E
Sbjct: 988 QKTELENKLQQQLTQAAQELAAEK--EKISVLQNNYEKS-QETFKQLQ-SDFYGRESELL 1043
Query: 153 SHAGPANTHLKSENDKLKIALTQSAAN----------VKKWEIELQTLRESNARLTTALQ 202
+ LKS +KL +A +N +++ + TL + +A+ LQ
Sbjct: 1044 A----TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
Query: 203 ESAASVEQWKRQFSICRDENDRLRNKIDELEE-QCSEINREKEKNTQLKRRIEELEAELR 261
E +++ +++ S+ E ++K+ E+EE +C R++++ T+L EEL++
Sbjct: 1100 ERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKC----RQEKEITKLN---EELKSHKL 1152
Query: 262 EKETELKDLRKQSEIIPQLMSECEYVSEKLEAA----ERDNQNLEDKVRSLKTDIEESKY 317
E E+ +L+ +++ Q E + ++ L+AA +R+ Q L+D+V+ EE +
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK-----EEEEL 1207
Query: 318 RQRHLKVELKSFLEVLDGKI 337
++ ++ E K E+ + ++
Sbjct: 1208 KKEFIEKEAKLHSEIKEKEV 1227
Score = 45.1 bits (105), Expect = 1e-04
Identities = 43/235 (18%), Positives = 103/235 (43%), Gaps = 32/235 (13%)
Query: 152 ASHAGPANTHLKSENDKL---KIALTQSAANVKKWEIE--------LQTLRESNARLTTA 200
+ H G +N LK ++ L ++ Q++ +KW E Q L++ A+
Sbjct: 70 SGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGL 129
Query: 201 LQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEI-----------NREKEKNTQL 249
+ +S+A ++ ++Q + EN ++ D E++ +++ + E+
Sbjct: 130 VTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAA 189
Query: 250 KRRIEELEAELREKETELKDLRKQS------EIIPQLMSECEYVSEKLE----AAERDNQ 299
++++ L EL ++ T ++DL+ + E + L E V ++ ER+++
Sbjct: 190 EQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESE 249
Query: 300 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 354
L+D+ + L++ S+ L+ EL + + + +L + +++L N
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304
Score = 44.7 bits (104), Expect = 1e-04
Identities = 61/268 (22%), Positives = 111/268 (41%), Gaps = 37/268 (13%)
Query: 97 TKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDE------ 150
TK+ E K+ + ++K Q ++ S +Q + + Q +G E
Sbjct: 386 TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS 445
Query: 151 -----KASHAGPANTHLKSENDKLKIALTQSAA------NVKKWEIELQTLRESNARLTT 199
K L ++LK +T S K+ E Q L++S T
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST---TA 502
Query: 200 ALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAE 259
L+E+ +EQ RQ D++ +++N LE + + + KE + L++ E+L A+
Sbjct: 503 KLREAQNDLEQVLRQIG---DKDQKIQN----LE---ALLQKSKENISLLEKEREDLYAK 552
Query: 260 LREKETELKDLRKQSEIIPQLMSECEYVSEKL----EAAERDNQNLEDKVRSLKTDIEES 315
++ E E L + E L + ++EKL E+ ++ +NL D+V+ K + +
Sbjct: 553 IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
Query: 316 KYRQRHLKV---ELKSFLEVLDGKIDDL 340
+ R L+ EL S L K+ L
Sbjct: 613 QDRVLSLETSVNELNSQLNESKEKVSQL 640
Score = 43.1 bits (100), Expect = 4e-04
Identities = 51/231 (22%), Positives = 105/231 (45%), Gaps = 46/231 (19%)
Query: 93 EQQLTKFAE-----KFQEVKEAAKIAKDKT---QEKIETSSNHSQESGRETPSSTQASSV 144
E+++TK E K + +KE + K Q+K+E +A S+
Sbjct: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQG--------------KADSL 1182
Query: 145 NGTDDEKASHAGPANTHLKSENDKLKIALTQSAAN----VKKWEIELQTLRESNARLT-- 198
+++ + +K E ++LK + A +K+ E+ ++ E+ A+LT
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQ 1242
Query: 199 -TALQESAASV-EQW---KRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRI 253
TAL E+ +V ++W +R+ S + D LR +I LE N + E+ L+R +
Sbjct: 1243 ITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ--NNQDERRALLERCL 1300
Query: 254 EELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDK 304
+ E E+ + +T++ +L++ + + + ++ R+NQ+L+ K
Sbjct: 1301 KG-EGEIEKLQTKVLELQR----------KLDNTTAAVQELGRENQSLQIK 1340
Score = 37.4 bits (85), Expect = 0.021
Identities = 46/240 (19%), Positives = 108/240 (45%), Gaps = 31/240 (12%)
Query: 96 LTKFAEKFQEVKEAAKIAK---DKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
+T ++ Q+++ + K K ++ ++++E Q+ + T +S+ + +++
Sbjct: 85 VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
Query: 153 SHAGPANTHLKSENDKLKIALTQSA---ANVKKWEIELQTLRESN----ARLTTALQESA 205
A N ++K D + Q A A++K E ++LRE+ RLT L + A
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204
Query: 206 ASVEQWKRQF---------SICRDENDRLRNKIDELE-EQCSEINREKEKNTQLKRRIEE 255
++ K + ++ + E +++ +D + E+ E + K++ +L+ +
Sbjct: 205 TVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYAS 264
Query: 256 LEAELREKETEL-----------KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDK 304
EA + + +EL ++L+K + +L + + ++E L E+D LE+K
Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEK 324
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 59.7 bits (143), Expect = 4e-09
Identities = 68/289 (23%), Positives = 126/289 (43%), Gaps = 43/289 (14%)
Query: 91 SSEQQLTKFAEKFQEVKEA---------AKIAKDKTQEKIETSSNHSQESGRETPSSTQA 141
+ E+++ K +K +E++E AK+ K+ +E S Q + + + QA
Sbjct: 951 NQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA-QA 1009
Query: 142 SSVNGTD-------DEKASHAGPANTHLKSENDKLKI---ALTQSAANVKK-WEIELQTL 190
+S +D ++K H + ND + I L Q A +++ EI+LQ
Sbjct: 1010 NSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK 1069
Query: 191 RESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSE----INREKEKN 246
+ A L + E+ ++ + ++E + ++EL+EQ + +N +
Sbjct: 1070 EQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDE 1129
Query: 247 TQLKRRIEELEAEL----------REKETELK-----DLRKQSEIIPQLMSECEYVSEKL 291
T+LK +E+LE +L +E+ ELK D RK SE+ +L + E
Sbjct: 1130 TKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLK 1189
Query: 292 EAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 340
+ E+ N++LEDK K EE + L + K +L+ K ++L
Sbjct: 1190 SSHEKSNKSLEDKSLEFKKLSEELAIQ---LDICCKKTEALLEAKTNEL 1235
Score = 51.2 bits (121), Expect = 1e-06
Identities = 60/258 (23%), Positives = 123/258 (47%), Gaps = 46/258 (17%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSST--QASSVNGTDDEK 151
+Q+T E+ +E KE ++ A + EK +++ ++E+ R+ + Q ++ T +E+
Sbjct: 392 KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE 451
Query: 152 ASHAGPANTHLKSENDKLKIALTQSAANVKKWEIEL--QTLRESNARLTTALQESAASVE 209
+I+L Q + VK+ +++ ++ E A+L ++ A E
Sbjct: 452 ------------------RISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE 493
Query: 210 Q--WKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELE----AELREK 263
Q K+ + R+ ++++ +++ + + +I++EKE+ L +EELE A L E
Sbjct: 494 QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA--LEELELQKKAILTES 551
Query: 264 ETELKDLRKQSEIIPQLMSECEYVSEK---------------LEAAE-RDNQNLEDKVRS 307
E +L+DL++++E + E E EK LEA + + N+ + V
Sbjct: 552 ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK 611
Query: 308 LKTDIEESKYRQRHLKVE 325
KT++E K++Q L E
Sbjct: 612 HKTELESLKHQQDALWTE 629
Score = 50.8 bits (120), Expect = 2e-06
Identities = 53/245 (21%), Positives = 108/245 (44%), Gaps = 23/245 (9%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
EQ++ + KE ++ ++ K E Q GR P+ + T+++
Sbjct: 1853 EQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEEN---TEEKSK 1909
Query: 153 SHAGPAN--THLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQ 210
SH ++++++++ L+ L + +K E+ L++ L +E +E
Sbjct: 1910 SHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD---LRMLRKEHQQELEI 1966
Query: 211 WKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELRE-----KET 265
K+++ R+E + + EL+ + +E NTQL ++ +ELE ++E +E
Sbjct: 1967 LKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEV 2026
Query: 266 ELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLED--------KVRSLKTDIEE--S 315
E + L E QL+ + + L+ + + + D KVR L+T +EE
Sbjct: 2027 EAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK 2086
Query: 316 KYRQR 320
KY+Q+
Sbjct: 2087 KYQQK 2091
Score = 49.7 bits (117), Expect = 4e-06
Identities = 43/186 (23%), Positives = 84/186 (45%), Gaps = 11/186 (5%)
Query: 160 THLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICR 219
+H + K+K AL V + E +L+ L E L + Q++ +E+ + Q +
Sbjct: 1251 SHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMK 1310
Query: 220 DENDRLRNKIDELEEQCSEINR---EKEKN-TQLKRRIEE-------LEAELREKETELK 268
+ + L + + L+++ + EKE TQLK+ + E ++ EL+EK+ E+
Sbjct: 1311 ADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEIS 1370
Query: 269 DLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKS 328
L KQ + + +SEK A + +++ L +++ ++ L E S
Sbjct: 1371 SLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKIS 1430
Query: 329 FLEVLD 334
LE +D
Sbjct: 1431 ALEQVD 1436
Score = 47.0 bits (110), Expect = 3e-05
Identities = 68/287 (23%), Positives = 114/287 (39%), Gaps = 46/287 (16%)
Query: 71 SQKFGQW---ADSR----ANTVFGL----------GFSSEQQLTKFAEKFQEVKEAAKIA 113
S KF +W A SR NTV L + ++Q+ E+ + +
Sbjct: 1439 SNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCL 1498
Query: 114 KDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIAL 173
K + ++ + S +ES ET +Q + + +D H ++S N+ LK
Sbjct: 1499 KGEMED--DKSKMEKKESNLETELKSQTARIMELED----HITQKTIEIESLNEVLKNYN 1552
Query: 174 TQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELE 233
Q K+ +LQ +E ++E+ + + Q + E L K ELE
Sbjct: 1553 QQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAE---LETKKKELE 1609
Query: 234 EQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQ--SEIIPQLMSECEYVSE-- 289
+ K K +LK + LE+E K ELK +Q + I QL+S+ E E
Sbjct: 1610 HVNLSV---KSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY 1666
Query: 290 -------------KLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLK 323
KL+ ER+ LE+K++S+++ E+ R K
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAK 1713
Score = 43.9 bits (102), Expect = 2e-04
Identities = 52/250 (20%), Positives = 110/250 (44%), Gaps = 13/250 (5%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDE 150
SSE+Q+ K +K E KE A+ ++ T+ K++T QE + +Q+ + E
Sbjct: 473 SSEEQIAKL-QKLHE-KELARKEQELTK-KLQTREREFQEQMKVALEKSQSEYLK-ISQE 528
Query: 151 KASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQ 210
K A L+ + K LT+S ++ + E +T R L ++L++S +
Sbjct: 529 KEQQESLALEELELQK---KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKN 585
Query: 211 WKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDL 270
+ ++ + NK + + + E K+ Q E+L+ ++ +TE++ L
Sbjct: 586 QSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
Query: 271 RKQSEIIPQLMSECEYVSEKLEAAERDNQNLE------DKVRSLKTDIEESKYRQRHLKV 324
R++ E + + + + + + E + + LE ++ SL +++ E + L+
Sbjct: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEE 705
Query: 325 ELKSFLEVLD 334
EL + D
Sbjct: 706 ELSVLKDQTD 715
Score = 37.7 bits (86), Expect = 0.016
Identities = 44/256 (17%), Positives = 105/256 (41%), Gaps = 9/256 (3%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRET-PSSTQASSVNGTDD 149
S+ +Q+ ++ KF E K+ A+ + Q ++ + +E Q + + D
Sbjct: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD 1489
Query: 150 EKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVE 209
++ ++ + K++ + +K + L + + T ++ ++
Sbjct: 1490 QQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
Query: 210 QWKRQFSICRDENDRLRNKIDEL-EEQCSEINREKEKNTQLKRRIEELEAELREKETELK 268
+ +Q I E + EL EE+ + + +EK L+ ++ ++AEL K+ EL+
Sbjct: 1550 NYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE 1609
Query: 269 ----DLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD-IEESKYRQRHLK 323
++ + E + L E SE + E K+ ++K + + + ++ K
Sbjct: 1610 HVNLSVKSKEEELKALEDRLE--SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYK 1667
Query: 324 VELKSFLEVLDGKIDD 339
+S L L+ K+ +
Sbjct: 1668 KGTESHLSELNTKLQE 1683
Score = 35.8 bits (81), Expect = 0.060
Identities = 54/257 (21%), Positives = 116/257 (45%), Gaps = 33/257 (12%)
Query: 96 LTKFAEKFQEVKEAAKIAKDKTQE---KIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
LT+ K +++++ A+ + + E +E S ++ ++ +A N + E
Sbjct: 548 LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEK-NKHNKEIT 606
Query: 153 SHAGPANTHLKSENDKLKIALTQSAANVKK-WEIELQTLRESNARLTTALQESAASVEQW 211
T L+S + T+ +K+ ++ E++ LRE + L + + Q
Sbjct: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ- 665
Query: 212 KRQFSICRDENDRLRNKID----ELEEQCSEI-------NREKEKNTQLKRRIEELEAEL 260
+ + N++ K+D ELE SE+ ++ +E+ + LK + ++++ EL
Sbjct: 666 ----AHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQEL 721
Query: 261 REKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQR 320
K E K+ +Q + ++ E E ++ E A L+D++ L+ ++E R +
Sbjct: 722 EAKMDEQKNHHQQQ--VDSIIKEHEVSIQRTEKA------LKDQINQLELLLKE---RDK 770
Query: 321 HLKVELKSFLEVLDGKI 337
HLK E ++ +E L+ I
Sbjct: 771 HLK-EHQAHVENLEADI 786
Score = 34.3 bits (77), Expect = 0.17
Identities = 34/119 (28%), Positives = 55/119 (46%), Gaps = 28/119 (23%)
Query: 214 QFSICRDEN--DRLRNKIDELEEQCSEINREKEK-NTQLKRRIEELEAELREKETELKDL 270
Q + R EN R + I +EQC+ + EKE QL R++ELE ++KDL
Sbjct: 285 QQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELE--------KIKDL 336
Query: 271 R--KQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 327
+++++I QL RD +NL +++ K + RQ H +E+K
Sbjct: 337 HMAEKTKLITQL---------------RDAKNLIEQLEQDKGMVIAETKRQMHETLEMK 380
Score = 34.3 bits (77), Expect = 0.17
Identities = 31/199 (15%), Positives = 87/199 (43%), Gaps = 10/199 (5%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEK 151
+E++ K ++ +++ ++ + + Q+++E + E Q +
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTL 1994
Query: 152 ASHAGPANTHLKSENDKLKIALTQSAANVKKWEIEL-QTLRESNARLTTALQESAASVEQ 210
NT L + +L++ + ++ ++ E EL ++ +E +L + E +++
Sbjct: 1995 KQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKR 2054
Query: 211 WKRQFSICRD-ENDRLRNKIDELEEQCSEINREKEKNTQLKRR-------IEELEAELRE 262
+++ D + + K+ +L+ Q E+ ++ ++ + + I EL+ +L +
Sbjct: 2055 TAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQ 2114
Query: 263 KETELKDLR-KQSEIIPQL 280
K T + D + K+ E Q+
Sbjct: 2115 KTTLISDSKLKEQEFREQI 2133
>gi|110347443 TATA element modulatory factor 1 [Homo sapiens]
Length = 1093
Score = 59.3 bits (142), Expect = 5e-09
Identities = 61/267 (22%), Positives = 113/267 (42%), Gaps = 28/267 (10%)
Query: 102 KFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETP----SSTQASSVNGTDDEKASHAGP 157
K +EV E I ++ + +E S + E P SST + D+ A P
Sbjct: 376 KSEEVNETLVIPTEEAE--MEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEP 433
Query: 158 ANTHLKSENDKLKIALTQSAANVK--KWEIELQTLRESNARLTTALQESAASVEQWKRQF 215
A + ++ ++K + T N K K E +L +L + A L A + + K +
Sbjct: 434 AESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEES 493
Query: 216 SICRDENDRLRNKIDELEEQ----CSEINREKEKNTQLKRRI------EELEAELREKET 265
S D +I E E++ C E + K++ +K + E L+EK+
Sbjct: 494 SSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDE 553
Query: 266 ELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE 325
+++ L ++ E + + + +KL A +++N+N+ K+ ++EE E
Sbjct: 554 QIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEE----------E 603
Query: 326 LKSFLEVLDGKIDDLHDFRRGLSKLGT 352
L+ +VLDGK + R + KL +
Sbjct: 604 LQHLKQVLDGKEEVEKQHRENIKKLNS 630
Score = 43.1 bits (100), Expect = 4e-04
Identities = 55/210 (26%), Positives = 89/210 (42%), Gaps = 47/210 (22%)
Query: 117 TQEKIETSSNHSQESGRETPSSTQASSVNGTD-----------DEKASHA-GPANTHLKS 164
TQE I+ S TP+ +++SS++G D DE H+ GP
Sbjct: 912 TQETIK-EKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANG 970
Query: 165 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 224
N + + ++ ++ + +L+ LRE T LQ ++E+ + SI +E +
Sbjct: 971 SNLYDAVRMGAGSSIIENLQSQLK-LREGEI---THLQLEIGNLEKTR---SIMAEELVK 1023
Query: 225 LRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSEC 284
L N+ DELEE+ EI + + T+L+DL ++ I Q+
Sbjct: 1024 LTNQNDELEEKVKEIPKLR---------------------TQLRDLDQRYNTILQM---- 1058
Query: 285 EYVSEKLEAAERDNQNLEDKVRSLKTDIEE 314
EK E AE +LED KT I+E
Sbjct: 1059 --YGEKAEEAEELRLDLEDVKNMYKTQIDE 1086
Score = 40.0 bits (92), Expect = 0.003
Identities = 43/206 (20%), Positives = 88/206 (42%), Gaps = 26/206 (12%)
Query: 118 QEKIETSSNHSQESGRETPSST----------------QASSVNGTDDEKASHAGPANTH 161
Q++++ + N +QE + S+T Q SS + + G + T
Sbjct: 747 QQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTL 806
Query: 162 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 221
L + ++ + A + AN +I++ ++ N+ L A +E K + DE
Sbjct: 807 LAAAVERERAATEELLAN----KIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDE 862
Query: 222 NDRLRNKIDELEEQ----CSEINREKE-KNTQLKRRIEELEAELREKETELKDLRKQSEI 276
N+R + +++ L+++ E +EK N+QL+ ++E E R+K ++ K+ E
Sbjct: 863 NNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQE-RKKAIFTQETIKEKER 921
Query: 277 IPQLMSECEYVSEKLEAAERDNQNLE 302
P +S +S + D L+
Sbjct: 922 KPFSVSSTPTMSRSSSISGVDMAGLQ 947
Score = 34.7 bits (78), Expect = 0.13
Identities = 54/233 (23%), Positives = 99/233 (42%), Gaps = 29/233 (12%)
Query: 98 KFAEKFQEVKEAAKIAKDKTQEKIETS-SNHSQESGRETPSSTQASSVNGTDDEKASHAG 156
+F + E +EA ++ K + +E + N E R S+ SS+ ++ + A
Sbjct: 452 EFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAE 511
Query: 157 PANTHLKSENDKLKIALTQSAANVKKWEIELQT----------LRESNARLTTALQESAA 206
E D K + N+K+ EL T L+E + ++ ++E
Sbjct: 512 KKVQLACKERDAAK----KEIKNIKE---ELATRLNSSETADLLKEKDEQIRGLMEEGEK 564
Query: 207 SVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETE 266
+Q +I + +LR K E E +++N+ K +L+ ++ L+ L KE
Sbjct: 565 LSKQQLHNSNIIK----KLRAKDKENENMVAKLNK---KVKELEEELQHLKQVLDGKEEV 617
Query: 267 LKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQ 319
K R E I +L S E + L + D LE+K RS++ + +S Y++
Sbjct: 618 EKQHR---ENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAAL-DSAYKE 666
Score = 33.1 bits (74), Expect = 0.39
Identities = 49/248 (19%), Positives = 95/248 (38%), Gaps = 28/248 (11%)
Query: 100 AEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPS--STQASSVNGTDDEKASHAGP 157
A K E +EAA + K +E++ + +QE R+ + Q + A
Sbjct: 675 AAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAAR 734
Query: 158 ANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSI 217
+L+ E +L+ Q L+E+ R Q +++ RQ
Sbjct: 735 KEDYLRHEIGELQ-----------------QRLQEAENRNQELSQSVSSTTRPLLRQIEN 777
Query: 218 CRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEA---ELREKETELKDLRKQS 274
+ + ++LE+ S+ R E T L +E A EL + ++ + Q+
Sbjct: 778 LQATLGSQTSSWEKLEKNLSD--RLGESQTLLAAAVERERAATEELLANKIQMSSMESQN 835
Query: 275 EIIPQ----LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFL 330
++ Q ++ E +L E +N + ++ +LK + + R K L S L
Sbjct: 836 SLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQL 895
Query: 331 EVLDGKID 338
E+ K++
Sbjct: 896 EMERMKVE 903
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 59.3 bits (142), Expect = 5e-09
Identities = 53/233 (22%), Positives = 107/233 (45%), Gaps = 17/233 (7%)
Query: 94 QQLTKFAEKF---QEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDE 150
++L K A+K Q ++A +I + T+EK ET ++ + ++ + +
Sbjct: 1027 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1086
Query: 151 KASHAGPANTHLKSENDKLKI------ALTQSAANVKKWEIELQTLRESNARLTTALQES 204
+ L EN K++ L Q+AA + +L L+E N +L L S
Sbjct: 1087 NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ---QLSALQEENVKLAEELGRS 1143
Query: 205 AASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREK-EKNTQLKRRIEELEAELREK 263
V ++ +E L N++ E++++ S+ ++ E+ L++ I A L EK
Sbjct: 1144 RDEVTSHQK----LEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1199
Query: 264 ETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 316
+ EL+ LR + ++ + + + ++ E D LE KV++L+ ++E+K
Sbjct: 1200 DAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENK 1252
Score = 50.8 bits (120), Expect = 2e-06
Identities = 58/247 (23%), Positives = 111/247 (44%), Gaps = 34/247 (13%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEK 151
+EQ + A+K +E K+ + ++K+ETS N QE +A T + K
Sbjct: 940 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE--------LKARYERATSETK 991
Query: 152 ASHAGPANTHLKS---ENDKLKIALTQSAANVKKWEIELQTLRE--SNARLTTALQESAA 206
H K+ DKLK A +++ ++ EL+ LR+ A+ +++
Sbjct: 992 TKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ----ELEELRKQADKAKAAQTAEDAMQ 1047
Query: 207 SVEQWKRQ-------FSICRDENDRLRNKIDELEE----QCSEINREKEKNTQLKRRIEE 255
+EQ ++ + N +L+N++D L+E E+N+ KE T +++EE
Sbjct: 1048 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1107
Query: 256 LEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERD---NQNLEDKVRSLKTDI 312
E+ ET + ++S+ + L E ++E+L + + +Q LE++ L +
Sbjct: 1108 FRKEI---ETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQL 1164
Query: 313 EESKYRQ 319
E K R+
Sbjct: 1165 LEMKKRE 1171
Score = 46.6 bits (109), Expect = 3e-05
Identities = 58/288 (20%), Positives = 124/288 (43%), Gaps = 36/288 (12%)
Query: 68 TKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKT----QEKIET 123
T + FG ++ + L +++ ++L+K E + E A + K+ET
Sbjct: 525 TSLKEHFGAREETHQKEIKAL-YTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 583
Query: 124 SSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKW 183
+ Q++ E + S G E A A LK++ +K+++ N++
Sbjct: 584 AIASHQQAMEEL----KVSFSKGLGTETAEFA-----ELKTQIEKMRLDYQHEIENLQNQ 634
Query: 184 EI--------ELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN----DRLRNKIDE 231
+ E++ LR A+L ++E S+E + + D++ + NK+ E
Sbjct: 635 QDSERAAHAKEMEALR---AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQE 691
Query: 232 LEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKL 291
E + E+ + K + + I+ ++L+ E +L DL + + SE + + ++L
Sbjct: 692 AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQL 751
Query: 292 EAAERDNQNLE-------DKVRSLKTDIEESKYRQRHLKVELKSFLEV 332
EAAE+ ++LE K S+ +++ + + +L+ L +V
Sbjct: 752 EAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799
Score = 44.3 bits (103), Expect = 2e-04
Identities = 57/257 (22%), Positives = 108/257 (42%), Gaps = 18/257 (7%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
E L K E +VKE ++ + K E+ + N + + +T+ ++ KA
Sbjct: 683 EDTLNKLQEAEIKVKEL-EVLQAKCNEQTKVIDNFTSQL-----KATEEKLLDLDALRKA 736
Query: 153 SHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWK 212
S G KSE KL+ L + +K EIE + +T LQ + +
Sbjct: 737 SSEG------KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ 790
Query: 213 RQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRK 272
S + L ++ L+E+ +E + E+ ++R ++E +L +KE + L
Sbjct: 791 ENLSEVSQVKETLEKELQILKEKFAEAS---EEAVSVQRSMQETVNKLHQKEEQFNMLSS 847
Query: 273 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEV 332
E + + +++ E ++ E ER+ Q ++ K L+ DI E +L +
Sbjct: 848 DLEKLRENLADME--AKFREKDEREEQLIKAK-EKLENDIAEIMKMSGDNSSQLTKMNDE 904
Query: 333 LDGKIDDLHDFRRGLSK 349
L K D+ + + L+K
Sbjct: 905 LRLKERDVEELQLKLTK 921
Score = 43.9 bits (102), Expect = 2e-04
Identities = 37/171 (21%), Positives = 79/171 (46%), Gaps = 12/171 (7%)
Query: 184 EIELQTLRESNARLTT-------ALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQC 236
E ELQ L+E A + ++QE+ + Q + QF++ + ++LR + ++E +
Sbjct: 804 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 863
Query: 237 SEINREKEKNTQLKRRIEELEAELREKETE-LKDLRKQSEIIPQLMSECEYVSEKLEAAE 295
E + +E+ + K ++E AE+ + + L K ++ + + E + KL A
Sbjct: 864 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN 923
Query: 296 RDNQNLEDKVRSLKTDIEESKY----RQRHLKVELKSFLEVLDGKIDDLHD 342
+ L+ + + E+S+ + K EL+ L L+ K++ H+
Sbjct: 924 ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN 974
Score = 39.3 bits (90), Expect = 0.005
Identities = 49/212 (23%), Positives = 88/212 (41%), Gaps = 36/212 (16%)
Query: 124 SSNHSQESGRETPSSTQASSVNGTD------DEKASHAGPANTHLKSENDKLKIALTQSA 177
SS S+ SS A ++GT EK H L +E D + + ++
Sbjct: 327 SSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI----EQLLAERDLERAEVAKAT 382
Query: 178 ANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCS 237
++V + E EL R+ + + L+ A ++Q + E L N+++E + +
Sbjct: 383 SHVGEIEQELALARDGHDQHVLELE---AKMDQLRTMVEAADREKVELLNQLEEEKRKVE 439
Query: 238 EINREKEKNT-----------QLKRRIEELEAELREKETELKDLRKQSE---------II 277
++ E+ + K RI ELE +L + E+ +LR++ E +
Sbjct: 440 DLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMS 499
Query: 278 PQLMSECEYVSEKLEAAERDNQNLEDKVRSLK 309
L+ E + EKLE D+Q ++ SLK
Sbjct: 500 LSLLQEISSLQEKLEVTRTDHQR---EITSLK 528
Score = 37.7 bits (86), Expect = 0.016
Identities = 52/218 (23%), Positives = 96/218 (44%), Gaps = 37/218 (16%)
Query: 100 AEKFQEV----KEAAKIAKDKTQEKIETSSNHSQESGRETPSST-------QASSVNGTD 148
A+K Q++ +E K+A++ + + E +S+ E R ++ ++ + D
Sbjct: 1120 AQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1179
Query: 149 DEKASHAGPAN------THLKSENDKLKIALTQ---SAANVKKWEIELQTLRESNARLTT 199
+EKAS + T +E +KL+ +T A+ K +QTL +L
Sbjct: 1180 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL 1239
Query: 200 ALQESAASVEQWKRQFSIC-------RDENDRLR-NKIDELEEQCSEINREKEKNTQLKR 251
++ +++ KRQ S DE++R + ++ID L ++ R KN LK
Sbjct: 1240 KVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQR---KNQDLKM 1296
Query: 252 RIEEL-EAELREKETELK-----DLRKQSEIIPQLMSE 283
++E + EA L +L D KQS+ P+L +
Sbjct: 1297 KVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCD 1334
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 59.3 bits (142), Expect = 5e-09
Identities = 53/233 (22%), Positives = 107/233 (45%), Gaps = 17/233 (7%)
Query: 94 QQLTKFAEKF---QEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDE 150
++L K A+K Q ++A +I + T+EK ET ++ + ++ + +
Sbjct: 1062 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1121
Query: 151 KASHAGPANTHLKSENDKLKI------ALTQSAANVKKWEIELQTLRESNARLTTALQES 204
+ L EN K++ L Q+AA + +L L+E N +L L S
Sbjct: 1122 NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ---QLSALQEENVKLAEELGRS 1178
Query: 205 AASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREK-EKNTQLKRRIEELEAELREK 263
V ++ +E L N++ E++++ S+ ++ E+ L++ I A L EK
Sbjct: 1179 RDEVTSHQK----LEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234
Query: 264 ETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 316
+ EL+ LR + ++ + + + ++ E D LE KV++L+ ++E+K
Sbjct: 1235 DAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENK 1287
Score = 50.8 bits (120), Expect = 2e-06
Identities = 58/247 (23%), Positives = 111/247 (44%), Gaps = 34/247 (13%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEK 151
+EQ + A+K +E K+ + ++K+ETS N QE +A T + K
Sbjct: 975 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE--------LKARYERATSETK 1026
Query: 152 ASHAGPANTHLKS---ENDKLKIALTQSAANVKKWEIELQTLRE--SNARLTTALQESAA 206
H K+ DKLK A +++ ++ EL+ LR+ A+ +++
Sbjct: 1027 TKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ----ELEELRKQADKAKAAQTAEDAMQ 1082
Query: 207 SVEQWKRQ-------FSICRDENDRLRNKIDELEE----QCSEINREKEKNTQLKRRIEE 255
+EQ ++ + N +L+N++D L+E E+N+ KE T +++EE
Sbjct: 1083 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1142
Query: 256 LEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERD---NQNLEDKVRSLKTDI 312
E+ ET + ++S+ + L E ++E+L + + +Q LE++ L +
Sbjct: 1143 FRKEI---ETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQL 1199
Query: 313 EESKYRQ 319
E K R+
Sbjct: 1200 LEMKKRE 1206
Score = 46.6 bits (109), Expect = 3e-05
Identities = 58/288 (20%), Positives = 124/288 (43%), Gaps = 36/288 (12%)
Query: 68 TKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKT----QEKIET 123
T + FG ++ + L +++ ++L+K E + E A + K+ET
Sbjct: 560 TSLKEHFGAREETHQKEIKAL-YTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 618
Query: 124 SSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKW 183
+ Q++ E + S G E A A LK++ +K+++ N++
Sbjct: 619 AIASHQQAMEEL----KVSFSKGLGTETAEFA-----ELKTQIEKMRLDYQHEIENLQNQ 669
Query: 184 EI--------ELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN----DRLRNKIDE 231
+ E++ LR A+L ++E S+E + + D++ + NK+ E
Sbjct: 670 QDSERAAHAKEMEALR---AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQE 726
Query: 232 LEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKL 291
E + E+ + K + + I+ ++L+ E +L DL + + SE + + ++L
Sbjct: 727 AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQL 786
Query: 292 EAAERDNQNLE-------DKVRSLKTDIEESKYRQRHLKVELKSFLEV 332
EAAE+ ++LE K S+ +++ + + +L+ L +V
Sbjct: 787 EAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 834
Score = 44.3 bits (103), Expect = 2e-04
Identities = 57/257 (22%), Positives = 108/257 (42%), Gaps = 18/257 (7%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
E L K E +VKE ++ + K E+ + N + + +T+ ++ KA
Sbjct: 718 EDTLNKLQEAEIKVKEL-EVLQAKCNEQTKVIDNFTSQL-----KATEEKLLDLDALRKA 771
Query: 153 SHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWK 212
S G KSE KL+ L + +K EIE + +T LQ + +
Sbjct: 772 SSEG------KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ 825
Query: 213 RQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRK 272
S + L ++ L+E+ +E + E+ ++R ++E +L +KE + L
Sbjct: 826 ENLSEVSQVKETLEKELQILKEKFAEAS---EEAVSVQRSMQETVNKLHQKEEQFNMLSS 882
Query: 273 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEV 332
E + + +++ E ++ E ER+ Q ++ K L+ DI E +L +
Sbjct: 883 DLEKLRENLADME--AKFREKDEREEQLIKAK-EKLENDIAEIMKMSGDNSSQLTKMNDE 939
Query: 333 LDGKIDDLHDFRRGLSK 349
L K D+ + + L+K
Sbjct: 940 LRLKERDVEELQLKLTK 956
Score = 43.9 bits (102), Expect = 2e-04
Identities = 37/171 (21%), Positives = 79/171 (46%), Gaps = 12/171 (7%)
Query: 184 EIELQTLRESNARLTT-------ALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQC 236
E ELQ L+E A + ++QE+ + Q + QF++ + ++LR + ++E +
Sbjct: 839 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 898
Query: 237 SEINREKEKNTQLKRRIEELEAELREKETE-LKDLRKQSEIIPQLMSECEYVSEKLEAAE 295
E + +E+ + K ++E AE+ + + L K ++ + + E + KL A
Sbjct: 899 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN 958
Query: 296 RDNQNLEDKVRSLKTDIEESKY----RQRHLKVELKSFLEVLDGKIDDLHD 342
+ L+ + + E+S+ + K EL+ L L+ K++ H+
Sbjct: 959 ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN 1009
Score = 40.8 bits (94), Expect = 0.002
Identities = 50/187 (26%), Positives = 92/187 (49%), Gaps = 21/187 (11%)
Query: 133 RETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKL---KIALT---QSAANVKKWEIE 186
+ +PS++ SS++ +S P+ T L +E KI+ T Q A K+ IE
Sbjct: 308 KRSPSASSLSSMSSVASSVSSR--PSRTGLLTETSSRYARKISGTTALQEALKEKQQHIE 365
Query: 187 LQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR----LRNKIDELEEQCSEINRE 242
Q L E + + ++ + V + +++ ++ RD +D+ L K+D+L +RE
Sbjct: 366 -QLLAERDLE-RAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADRE 423
Query: 243 K-EKNTQL---KRRIEELEAELREKETELKDLRKQSEIIPQLMSECE--YVSEKLEAAER 296
K E QL KR++E+L+ + E+ DL Q+++ + E E + EK + A++
Sbjct: 424 KVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTK-ADK 482
Query: 297 DNQNLED 303
+ LED
Sbjct: 483 LQRELED 489
Score = 37.7 bits (86), Expect = 0.016
Identities = 52/218 (23%), Positives = 96/218 (44%), Gaps = 37/218 (16%)
Query: 100 AEKFQEV----KEAAKIAKDKTQEKIETSSNHSQESGRETPSST-------QASSVNGTD 148
A+K Q++ +E K+A++ + + E +S+ E R ++ ++ + D
Sbjct: 1155 AQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1214
Query: 149 DEKASHAGPAN------THLKSENDKLKIALTQ---SAANVKKWEIELQTLRESNARLTT 199
+EKAS + T +E +KL+ +T A+ K +QTL +L
Sbjct: 1215 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL 1274
Query: 200 ALQESAASVEQWKRQFSIC-------RDENDRLR-NKIDELEEQCSEINREKEKNTQLKR 251
++ +++ KRQ S DE++R + ++ID L ++ R KN LK
Sbjct: 1275 KVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQR---KNQDLKM 1331
Query: 252 RIEEL-EAELREKETELK-----DLRKQSEIIPQLMSE 283
++E + EA L +L D KQS+ P+L +
Sbjct: 1332 KVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCD 1369
Score = 32.0 bits (71), Expect = 0.86
Identities = 45/195 (23%), Positives = 78/195 (40%), Gaps = 37/195 (18%)
Query: 149 DEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLR-------ESNARLTTAL 201
D + + A +H+ +L +A +V + E ++ LR L L
Sbjct: 372 DLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQL 431
Query: 202 QESAASVEQWK---RQFSICRDENDRLRN----KIDELEE-------QCSEINREKEKN- 246
+E VE + + SI + + + +I ELE+ + ++ RE E
Sbjct: 432 EEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTR 491
Query: 247 ---TQLKRRIEELEAELREKETELKDLRKQSE---------IIPQLMSECEYVSEKLEAA 294
K RI ELE +L + E+ +LR++ E + L+ E + EKLE
Sbjct: 492 VATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVT 551
Query: 295 ERDNQNLEDKVRSLK 309
D+Q ++ SLK
Sbjct: 552 RTDHQR---EITSLK 563
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 59.3 bits (142), Expect = 5e-09
Identities = 65/258 (25%), Positives = 114/258 (44%), Gaps = 21/258 (8%)
Query: 81 RANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQ 140
R N F + LTK + + +KEA ++ D+ +E I + QES S Q
Sbjct: 1332 RLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQES-----QSKQ 1386
Query: 141 ASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTA 200
S+N + + + T + SE ++ K + + + EIE+ L +
Sbjct: 1387 EQSLNMKEKDNET------TKIVSEMEQFK----PKDSALLRIEIEMLGLSKRLQESHDE 1436
Query: 201 LQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINRE-KEKNTQLKRR---IEEL 256
++ A + +R + + E+D+L+ I E+ + E E K + LK + I EL
Sbjct: 1437 MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496
Query: 257 EAELREKETELKDLRKQSEII-PQLMSECEYVSEKLEAAE-RDNQNLEDKVRSLKTDIEE 314
L EKETE+ ++KQ E I +L ++ + + EK E + +++KV LK E
Sbjct: 1497 RVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEH 1556
Query: 315 SKYRQRHLKVELKSFLEV 332
K + L+ LE+
Sbjct: 1557 RKAKDSALQSIESKMLEL 1574
Score = 57.0 bits (136), Expect = 3e-08
Identities = 57/261 (21%), Positives = 112/261 (42%), Gaps = 26/261 (9%)
Query: 88 LGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGT 147
+ +++QL E ++ +E K K E++ + H +E+ ET Q V G
Sbjct: 958 MNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNL-HMEENTGETKDEFQQKMV-GI 1015
Query: 148 DDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRES-------------- 193
D ++ A T D I + ++ + + ELQ + ES
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
Query: 194 NARLTTALQESAASV-EQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRR 252
N +T QE + ++ K+Q I E + K EL C + +EK + ++
Sbjct: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135
Query: 253 IEELEAELREKETELKDLRKQSEIIPQLMSECE--------YVSEKLEAAERDNQNLEDK 304
++E + +L + E+ +++K+ I L +E + +E+LE A++ N+N E+
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEE- 1194
Query: 305 VRSLKTDIEESKYRQRHLKVE 325
V+S+ + + K Q+ + E
Sbjct: 1195 VKSITKERKVLKELQKSFETE 1215
Score = 53.9 bits (128), Expect = 2e-07
Identities = 55/259 (21%), Positives = 112/259 (43%), Gaps = 31/259 (11%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKAS 153
Q + K E+ + V+EA +I +D+ +E + +ES + + ++VN T ++
Sbjct: 1586 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645
Query: 154 HAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKR 213
HLK + + K+ L+ + N RLT L E+ + +
Sbjct: 1646 IE-----HLKEQFETQKL--------------NLENIETENIRLTQILHENLEEMRSVTK 1686
Query: 214 QFSICRDENDRLRNKIDELEEQCSE-INREKEKNTQLK----------RRIEELEAELRE 262
+ R + L+ + D+L+E E I R+ EK +LK I++L + E
Sbjct: 1687 ERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSE 1746
Query: 263 KETELKDLRKQSE-IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRH 321
K E+ +++K E L ++ + E+L A + ++ + L+ + E + +
Sbjct: 1747 KTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSN 1806
Query: 322 LKVELKSFLEVLDGKIDDL 340
++ +L++ L KI +L
Sbjct: 1807 MQKDLENSNAKLQEKIQEL 1825
Score = 52.0 bits (123), Expect = 8e-07
Identities = 51/257 (19%), Positives = 106/257 (41%), Gaps = 32/257 (12%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETP--------SSTQASSVN 145
+ +TK + + V+E K+ +D+ +E + + E E +
Sbjct: 1682 RSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLR 1741
Query: 146 GTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESA 205
G EK + L+ ND LK + ++ + L+ +E+ +L + E
Sbjct: 1742 GIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKT 1801
Query: 206 ASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKET 265
+ ++ L N +L+E+ E+ + + LK+ + E + ++ E E
Sbjct: 1802 DKLSNMQKD----------LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQ 1851
Query: 266 ELKDLRKQSEIIPQLMSECEYVSEKLE---------AAERDN-QNLEDKVR----SLKTD 311
K ++ QS + +L E +++KL ERDN + +E+ ++ LK
Sbjct: 1852 LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES 1911
Query: 312 IEESKYRQRHLKVELKS 328
++E+K R ++ ELK+
Sbjct: 1912 LQETKARDLEIQQELKT 1928
Score = 48.1 bits (113), Expect = 1e-05
Identities = 61/252 (24%), Positives = 111/252 (44%), Gaps = 36/252 (14%)
Query: 94 QQLTKFAEKFQEVKEAA--KIAKDKTQEKIETS----SNHSQESGRETPSSTQASSVNGT 147
+Q+++ EK E+K+ + AKD + IE+ +N QES E +
Sbjct: 1538 KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI-------QIMIK 1590
Query: 148 DDEKASHAGPANTHLKSENDKLKIALTQSAANVKK-WEIELQTLRESNARLTTALQESAA 206
+ E+ A L+ E D+LK + A +K+ E E Q L+ + T QE
Sbjct: 1591 EKEEMKRVQEA---LQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET---QEKMC 1644
Query: 207 SVEQWKRQFSI-------CRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAE 259
+E K QF EN RL + E E+ + +E++ ++ ++ +
Sbjct: 1645 EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQ 1704
Query: 260 LRE--KETELKDLRKQSE--IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEES 315
L+E +ET +DL KQ E I+ + E + +KL + N ++ +++ D+E S
Sbjct: 1705 LKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN---EISNMQKDLEHS 1761
Query: 316 K--YRQRHLKVE 325
+ + LK++
Sbjct: 1762 NDALKAQDLKIQ 1773
Score = 45.4 bits (106), Expect = 8e-05
Identities = 37/173 (21%), Positives = 78/173 (45%), Gaps = 10/173 (5%)
Query: 162 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 221
L E K + + Q + K E EL + A + L+E + +++ ++Q ++E
Sbjct: 1090 LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEE 1149
Query: 222 NDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM 281
++ KI+E+E +E+ ++ ++ EL +L E E+K + K+ +++ +L
Sbjct: 1150 MSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ 1209
Query: 282 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 334
E ERD +L +R ++ ++K + + LK E +D
Sbjct: 1210 KSFE--------TERD--HLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
Score = 44.7 bits (104), Expect = 1e-04
Identities = 45/202 (22%), Positives = 91/202 (45%), Gaps = 14/202 (6%)
Query: 162 LKSENDKLKIALTQSAANVK-------KWEIELQTLRESNARLTTALQESAASVEQWKRQ 214
+ SE DKL + + V+ K + +L T + + Q ++++
Sbjct: 773 ITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQK 832
Query: 215 FSICRDENDRLRNKIDELEEQCSEINREKEK-NTQLKRRIEELEAELREKETELKDLRKQ 273
+ + +EN+R+ +I L ++ + + T+L + +EL+ + RE + L ++ +
Sbjct: 833 YKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL 892
Query: 274 SEIIPQLMSECEYVS-EKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE---LKSF 329
E + S + V EK E+ Q LE+ V++L + ++ K Q L++E LKS
Sbjct: 893 KEQLENRDSTLQTVEREKTLITEKLQQTLEE-VKTLTQEKDDLKQLQESLQIERDQLKSD 951
Query: 330 L-EVLDGKIDDLHDFRRGLSKL 350
+ + ++ ID R L L
Sbjct: 952 IHDTVNMNIDTQEQLRNALESL 973
Score = 44.3 bits (103), Expect = 2e-04
Identities = 38/159 (23%), Positives = 77/159 (48%), Gaps = 16/159 (10%)
Query: 175 QSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEE 234
+SA K+WE +L++L+E N +L Q S+ + +D NK +
Sbjct: 2320 RSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQD------NKNPHVTS 2373
Query: 235 QCSEINREKEKNTQLKRRIEELEAELREKETEL----KDLRKQSEIIPQLMSECEYVSEK 290
+ +++ EK + +L+ + E + KE+++ K+L ++II +L ++ ++
Sbjct: 2374 RATQLTTEKIR--ELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKC 2431
Query: 291 LEAAERDNQNLEDKV----RSLKTDIEESKYRQRHLKVE 325
LE + Q L+DKV + K +IE+ K + + +E
Sbjct: 2432 LEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLE 2470
Score = 43.9 bits (102), Expect = 2e-04
Identities = 58/267 (21%), Positives = 114/267 (42%), Gaps = 35/267 (13%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNG-TDD--- 149
+ + K + + V+E K+ +D+ +E ++ + E +E ++ S + T D
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944
Query: 150 EKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVE 209
EK S + ++ + DK K L + ++K E++L ++E + E +E
Sbjct: 1945 EKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE----ME 2000
Query: 210 QWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKD 269
Q K+QF E Q + + N QL +++ E E+R E +
Sbjct: 2001 QLKKQF-----------------EAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDE 2043
Query: 270 LRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK-- 327
LR+ E + M ++++ E RD QN +V+ K + + Q+HL L+
Sbjct: 2044 LRRIKESLK--MERDQFIATLREMIARDRQN--HQVKPEKRLLSDG---QQHLTESLREK 2096
Query: 328 -SFLEVLDGKIDDLHDFRRGLSKLGTD 353
S ++ L + ++ D L++L D
Sbjct: 2097 CSRIKELLKRYSEMDDHYECLNRLSLD 2123
Score = 42.7 bits (99), Expect = 5e-04
Identities = 56/283 (19%), Positives = 116/283 (40%), Gaps = 42/283 (14%)
Query: 98 KFAEKFQEVKEAAKIAKD--KTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA 155
+ E E+K AK D + QE +++ S+ +E+ +E A + ++ K +H
Sbjct: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIV----AKHLETEEELKVAHC 1484
Query: 156 ---------GPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRES----NARLTTALQ 202
+L + ++ Q A K + ++Q + E N + + +Q
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Query: 203 ESAASVEQWKRQ-------FSICRDENDRLRNKIDELEEQCSEINREKE----------- 244
E ++Q+K + L N++ E +E+ + +EKE
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604
Query: 245 KNTQLKRRIEELEAELREKETELKDLRKQSEI--IPQLMSECEYVSEKLEAAERDNQNLE 302
+ QLK +E+ A+++E + + K + + + M E E++ E+ E + + +N+E
Sbjct: 1605 ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIE 1664
Query: 303 DKVRSLKTDIEESKYRQRHLKVE---LKSFLEVLDGKIDDLHD 342
+ L + E+ R + E L+S E L + D L +
Sbjct: 1665 TENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707
Score = 42.0 bits (97), Expect = 8e-04
Identities = 38/168 (22%), Positives = 83/168 (49%), Gaps = 17/168 (10%)
Query: 165 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 224
EN+++ + + +K++ L L+ + T LQE V++ +E ++
Sbjct: 839 ENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL-------NEMEQ 891
Query: 225 LRNKIDELEEQCSEINREKEKNTQ-LKRRIEELEAELREKETELKDLRKQSEI-IPQLMS 282
L+ +++ + + REK T+ L++ +EE++ +EK+ +LK L++ +I QL S
Sbjct: 892 LKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD-DLKQLQESLQIERDQLKS 950
Query: 283 EC-EYVSEKLEAAERDNQNLE------DKVRSLKTDIEESKYRQRHLK 323
+ + V+ ++ E+ LE + + +LK+ I E R H++
Sbjct: 951 DIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHME 998
Score = 39.7 bits (91), Expect = 0.004
Identities = 67/286 (23%), Positives = 124/286 (43%), Gaps = 46/286 (16%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKA 152
E +L++ ++ EV+E K + QEK + N +E S +N ++ K
Sbjct: 1112 EGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM------SEMQKKINEIENLKN 1165
Query: 153 SHAGPANT--HLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQ 210
T H+++E +L L ++ VK E + L+E LQ+S +
Sbjct: 1166 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKE--------LQKSFETERD 1217
Query: 211 WKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEA------ELREKE 264
R + I E L+ K +EL+ + +E +L+R + E A +L +
Sbjct: 1218 HLRGY-IREIEATGLQTK-EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSH 1275
Query: 265 TELKD----LRKQSEIIP---------QLMSECEYVSEKLEAAERDNQNL---EDKVRSL 308
T+L++ L ++ E++P + M+E E ++E ++ +D+ L E + L
Sbjct: 1276 TKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTE--QSTTKDSTTLARIEMERLRL 1333
Query: 309 KTDIEESKYRQRHLKVE---LKSFLEVLDGKIDDLHD-FRRGLSKL 350
+ES+ + L E LK+ E L+ K D L + R L+K+
Sbjct: 1334 NEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKI 1379
Score = 35.4 bits (80), Expect = 0.078
Identities = 57/266 (21%), Positives = 113/266 (42%), Gaps = 47/266 (17%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDE 150
SS+ +L + EK ++K+ + + E I+ ++S ES E P + + + +
Sbjct: 578 SSKVELLR--EKEDQIKKLQEYIDSQKLENIKMDLSYSLES-IEDPKQMKQTLFDA--ET 632
Query: 151 KASHAGPANTHLKSENDKLK----------------IALTQSAANVKK-----WEIELQT 189
A A + L+SEN +LK I L QS KK E ELQ+
Sbjct: 633 VALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQS 692
Query: 190 LRESNARLTTALQ-----------ESAASVEQWKRQFSICRDENDRLRNKI---DELEEQ 235
+LT+ + E + +++ + +EN+ LR ++ EL+
Sbjct: 693 AFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSL 752
Query: 236 CSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAE 295
SE+ R ++ +++ + EEL EK+ ++ + + L+ E + L +
Sbjct: 753 PSEVERLRK---EIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQ 809
Query: 296 RDNQNLEDKVRSLKT---DIEESKYR 318
+ ++ + + ++ KT D E+ KY+
Sbjct: 810 SNYKSTDQEFQNFKTLHMDFEQ-KYK 834
Score = 30.4 bits (67), Expect = 2.5
Identities = 35/156 (22%), Positives = 66/156 (42%), Gaps = 29/156 (18%)
Query: 179 NVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSE 238
N + E EL +LR L ++ E+ + + + +N +DE E E
Sbjct: 492 NQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL--------KEKNDLDEFE--ALE 541
Query: 239 INREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDN 298
+K++ QL I L+ ++ E +DL +L S+ E + EK
Sbjct: 542 RKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLEN------ELSSKVELLREK-------- 587
Query: 299 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 334
ED+++ L+ I+ K ++K++L LE ++
Sbjct: 588 ---EDQIKKLQEYIDSQKL--ENIKMDLSYSLESIE 618
Score = 29.3 bits (64), Expect = 5.6
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 10/104 (9%)
Query: 245 KNTQLKRRIEELEAELREKETELKDLRKQSEII-----PQLMSE---CEYVSEKLEAAER 296
KNT + EA L+ E+ DL+KQ E + Q M + + + EK +
Sbjct: 330 KNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKV 389
Query: 297 DNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 340
N+ +E+ R L T S Q+ LK + K + GKI+ +
Sbjct: 390 QNEKIENLTRMLVT--SSSLTLQQELKAKRKRRVTWCLGKINKM 431
Score = 28.5 bits (62), Expect = 9.5
Identities = 50/225 (22%), Positives = 91/225 (40%), Gaps = 32/225 (14%)
Query: 96 LTKFAEKFQEVKEAAKIAKDK----TQEKIETSSNHSQESGRETPSSTQASSVNGTDDEK 151
+ K ++ + +KE+ K+ +D+ +E I + Q + S + + EK
Sbjct: 2037 VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREK 2096
Query: 152 ASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQW 211
S +D + L + + +++K EIE Q +E + R+ L +
Sbjct: 2097 CSRIKELLKRYSEMDDHYE-CLNRLSLDLEK-EIEFQ--KELSMRVKANLSLPYLQTKHI 2152
Query: 212 KRQFSI---CRDENDRLRNKIDEL--------EEQCSEINR-------EKEKNTQLKRRI 253
++ F+ C E R+ K+ + EEQ IN+ E EK +L +I
Sbjct: 2153 EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKI 2212
Query: 254 EELEAELREKETELKDLRKQS------EIIPQLMSECEYVSEKLE 292
+ L+ + EL+DL+ E I + SE E+ S K E
Sbjct: 2213 QHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTE 2257
>gi|219842214 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform b [Homo sapiens]
Length = 943
Score = 58.9 bits (141), Expect = 7e-09
Identities = 58/279 (20%), Positives = 124/279 (44%), Gaps = 35/279 (12%)
Query: 38 YDVTRNSYRIISVDGAKVIINSTITPNMTF-TKTSQKFGQWADSRANTVFGLGFSSEQQL 96
YD T YR +S +S+ TP+ + T +S + +R N++ G+ + + +
Sbjct: 675 YDETYQRYRPVST-------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGI 727
Query: 97 TKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAG 156
TK E+ E +E K +DK+Q K +E R T S + + E+ S
Sbjct: 728 TKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTE 787
Query: 157 PANTHLKSENDKLKIALTQSAANVKKWEIEL-----QTLRESNARLTTALQESAASVEQW 211
+ +++ D + T S + +++ L + E ++ L++ ++ +
Sbjct: 788 EGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDST--DF 845
Query: 212 KRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEE---LEAELREK---ET 265
K+ + EN++L+ ++ + + +++ + EK TQ + R + LE E RE+ E
Sbjct: 846 KKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALER 905
Query: 266 ELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDK 304
+ ++ ++ +++P L + DNQ L+D+
Sbjct: 906 RISEMEEELKMLPDL--------------KADNQRLKDE 930
Score = 32.3 bits (72), Expect = 0.66
Identities = 69/311 (22%), Positives = 115/311 (36%), Gaps = 44/311 (14%)
Query: 82 ANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQE----------- 130
A G S+ + + EK +E KE K K+K +EK E+ ++ E
Sbjct: 620 AEKTIGRSRSTRTREQENEEKEKEEKE--KQDKEKQEEKKESETSREDEYKQKYSRTYDE 677
Query: 131 -SGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQT 189
R P ST +S+ + S + A++ L N + I S K+ E E +
Sbjct: 678 TYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEK 737
Query: 190 LRES------------NARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE-----L 232
E R + + V W + DEN++ + E
Sbjct: 738 REEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQD----SDENEQEQQSDTEEGSNKK 793
Query: 233 EEQCSEINREKEKNTQLKRRIEEL------EAELREKETELKDLRK-QSEIIPQLMSECE 285
E Q I+R + +T R + L + L E++ L K S +L +
Sbjct: 794 ETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQIL 853
Query: 286 YVSEKLEAAERD-NQNLED-KVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDF 343
+EKL+A D N L D K++ K + ++ R L K L+ +I ++ +
Sbjct: 854 AENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEE 913
Query: 344 RRGLSKLGTDN 354
+ L L DN
Sbjct: 914 LKMLPDLKADN 924
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 58.9 bits (141), Expect = 7e-09
Identities = 58/279 (20%), Positives = 124/279 (44%), Gaps = 35/279 (12%)
Query: 38 YDVTRNSYRIISVDGAKVIINSTITPNMTF-TKTSQKFGQWADSRANTVFGLGFSSEQQL 96
YD T YR +S +S+ TP+ + T +S + +R N++ G+ + + +
Sbjct: 762 YDETYQRYRPVST-------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGI 814
Query: 97 TKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAG 156
TK E+ E +E K +DK+Q K +E R T S + + E+ S
Sbjct: 815 TKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTE 874
Query: 157 PANTHLKSENDKLKIALTQSAANVKKWEIEL-----QTLRESNARLTTALQESAASVEQW 211
+ +++ D + T S + +++ L + E ++ L++ ++ +
Sbjct: 875 EGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDST--DF 932
Query: 212 KRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEE---LEAELREK---ET 265
K+ + EN++L+ ++ + + +++ + EK TQ + R + LE E RE+ E
Sbjct: 933 KKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALER 992
Query: 266 ELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDK 304
+ ++ ++ +++P L + DNQ L+D+
Sbjct: 993 RISEMEEELKMLPDL--------------KADNQRLKDE 1017
Score = 32.3 bits (72), Expect = 0.66
Identities = 69/311 (22%), Positives = 115/311 (36%), Gaps = 44/311 (14%)
Query: 82 ANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQE----------- 130
A G S+ + + EK +E KE K K+K +EK E+ ++ E
Sbjct: 707 AEKTIGRSRSTRTREQENEEKEKEEKE--KQDKEKQEEKKESETSREDEYKQKYSRTYDE 764
Query: 131 -SGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQT 189
R P ST +S+ + S + A++ L N + I S K+ E E +
Sbjct: 765 TYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEK 824
Query: 190 LRES------------NARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE-----L 232
E R + + V W + DEN++ + E
Sbjct: 825 REEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQD----SDENEQEQQSDTEEGSNKK 880
Query: 233 EEQCSEINREKEKNTQLKRRIEEL------EAELREKETELKDLRK-QSEIIPQLMSECE 285
E Q I+R + +T R + L + L E++ L K S +L +
Sbjct: 881 ETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQIL 940
Query: 286 YVSEKLEAAERD-NQNLED-KVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDF 343
+EKL+A D N L D K++ K + ++ R L K L+ +I ++ +
Sbjct: 941 AENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEE 1000
Query: 344 RRGLSKLGTDN 354
+ L L DN
Sbjct: 1001 LKMLPDLKADN 1011
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit 12A
isoform a [Homo sapiens]
Length = 1030
Score = 58.9 bits (141), Expect = 7e-09
Identities = 58/279 (20%), Positives = 124/279 (44%), Gaps = 35/279 (12%)
Query: 38 YDVTRNSYRIISVDGAKVIINSTITPNMTF-TKTSQKFGQWADSRANTVFGLGFSSEQQL 96
YD T YR +S +S+ TP+ + T +S + +R N++ G+ + + +
Sbjct: 762 YDETYQRYRPVST-------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGI 814
Query: 97 TKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAG 156
TK E+ E +E K +DK+Q K +E R T S + + E+ S
Sbjct: 815 TKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTE 874
Query: 157 PANTHLKSENDKLKIALTQSAANVKKWEIEL-----QTLRESNARLTTALQESAASVEQW 211
+ +++ D + T S + +++ L + E ++ L++ ++ +
Sbjct: 875 EGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDST--DF 932
Query: 212 KRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEE---LEAELREK---ET 265
K+ + EN++L+ ++ + + +++ + EK TQ + R + LE E RE+ E
Sbjct: 933 KKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALER 992
Query: 266 ELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDK 304
+ ++ ++ +++P L + DNQ L+D+
Sbjct: 993 RISEMEEELKMLPDL--------------KADNQRLKDE 1017
Score = 32.3 bits (72), Expect = 0.66
Identities = 69/311 (22%), Positives = 115/311 (36%), Gaps = 44/311 (14%)
Query: 82 ANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQE----------- 130
A G S+ + + EK +E KE K K+K +EK E+ ++ E
Sbjct: 707 AEKTIGRSRSTRTREQENEEKEKEEKE--KQDKEKQEEKKESETSREDEYKQKYSRTYDE 764
Query: 131 -SGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQT 189
R P ST +S+ + S + A++ L N + I S K+ E E +
Sbjct: 765 TYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEK 824
Query: 190 LRES------------NARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE-----L 232
E R + + V W + DEN++ + E
Sbjct: 825 REEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQD----SDENEQEQQSDTEEGSNKK 880
Query: 233 EEQCSEINREKEKNTQLKRRIEEL------EAELREKETELKDLRK-QSEIIPQLMSECE 285
E Q I+R + +T R + L + L E++ L K S +L +
Sbjct: 881 ETQTDSISRYETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQIL 940
Query: 286 YVSEKLEAAERD-NQNLED-KVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDF 343
+EKL+A D N L D K++ K + ++ R L K L+ +I ++ +
Sbjct: 941 AENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEE 1000
Query: 344 RRGLSKLGTDN 354
+ L L DN
Sbjct: 1001 LKMLPDLKADN 1011
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 58.5 bits (140), Expect = 9e-09
Identities = 52/250 (20%), Positives = 108/250 (43%), Gaps = 7/250 (2%)
Query: 102 KFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTH 161
KF ++ + + D ++ + + ++++ + + S Q +G +DE + H
Sbjct: 935 KFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD-H 993
Query: 162 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 221
L+ E + ++ LT ++ + L E L E QW+ S+ DE
Sbjct: 994 LRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDE 1053
Query: 222 NDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELE--AELREKETELKDLRKQSEIIPQ 279
+ ++ EL+ ++ EK+ + +RI E EL KE + + L Q + Q
Sbjct: 1054 KSQFECRVRELQRM---LDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQ 1110
Query: 280 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDD 339
+ + E +S+KL E+ + LE RSL+ +E + ++ L E + +D + +
Sbjct: 1111 KL-KAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNH 1169
Query: 340 LHDFRRGLSK 349
+ +GL +
Sbjct: 1170 IFRLTQGLQE 1179
Score = 52.8 bits (125), Expect = 5e-07
Identities = 31/104 (29%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 224 RLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ---- 279
+L K EL++ + ++ +++ T+L RR+ E+EA L +KE ELK Q ++ Q
Sbjct: 450 KLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLAT 509
Query: 280 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLK 323
++EC + LE A + +DK L DI E + + +K
Sbjct: 510 YITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIK 553
Score = 49.7 bits (117), Expect = 4e-06
Identities = 49/235 (20%), Positives = 102/235 (43%), Gaps = 8/235 (3%)
Query: 72 QKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQES 131
QKF + +++A + E+QL K + Q+ + ++ + +T+ + E S H ++
Sbjct: 815 QKF--YLETQAGKLEAQNRKLEEQLEKISH--QDHSDKNRLLELETRLR-EVSLEHEEQK 869
Query: 132 GRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLR 191
T+ + + + A L+S+ + K L ++ A ++ L R
Sbjct: 870 LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 929
Query: 192 ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKR 251
+ R AL+ S + + Q + ++N L N+ L +Q E + ++ QL+
Sbjct: 930 DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRS 989
Query: 252 RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVR 306
++ L E+ E+E + L Q + + L + C + E++ E N L +K R
Sbjct: 990 EVDHLRREITEREMQ---LTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKER 1041
Score = 47.4 bits (111), Expect = 2e-05
Identities = 57/269 (21%), Positives = 109/269 (40%), Gaps = 39/269 (14%)
Query: 101 EKFQEVKEAAKIAKDKTQEKI---ETSSN----HSQESGRETPSSTQASSVNGTDDEKAS 153
+K Q +E K+ ++ ++ + ET N H +E+ + ++ ++ D K
Sbjct: 716 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIR 775
Query: 154 HAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKR 213
L N + + N+K E + LR+ L T + A + +
Sbjct: 776 SLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE 835
Query: 214 QFSICRDENDRLRNKIDELEEQCSEINRE-KEKNTQLKRRIEELEAELREKETELKDLRK 272
Q ++ +N++ ELE + E++ E +E+ +LKR++ EL+ L+E+E++L L
Sbjct: 836 QLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTAL-- 893
Query: 273 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEV 332
+ AA LE ++R KT++EE+ L + +
Sbjct: 894 ----------------QAARAA------LESQLRQAKTELEETTAEAEEEIQALTAHRDE 931
Query: 333 LDGKIDDLH-------DFRRGLSKLGTDN 354
+ K D L D L++L DN
Sbjct: 932 IQRKFDALRNSCTVITDLEEQLNQLTEDN 960
Score = 43.9 bits (102), Expect = 2e-04
Identities = 51/259 (19%), Positives = 102/259 (39%), Gaps = 9/259 (3%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKAS 153
++ K + + E+ + + AK++ + ++E N S +A + E
Sbjct: 646 EKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQV 705
Query: 154 HAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKR 213
A HLK + + + +KK + +TL R E + + K
Sbjct: 706 SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKA 765
Query: 214 QFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRI-EELEAELREK----ETELK 268
+ + L +I EL E +++ TQ + EE+ +ELR++ ET+
Sbjct: 766 MINAMDSKIRSLEQRIVELSE-ANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAG 824
Query: 269 DLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKS 328
L Q+ +L + E +S + + + LE ++R + + EE K + EL+
Sbjct: 825 KLEAQNR---KLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQL 881
Query: 329 FLEVLDGKIDDLHDFRRGL 347
L+ + ++ L R L
Sbjct: 882 SLQERESQLTALQAARAAL 900
Score = 41.6 bits (96), Expect = 0.001
Identities = 59/278 (21%), Positives = 118/278 (42%), Gaps = 54/278 (19%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSST------------- 139
EQ++T+ + EV+ +Q+++E ++ +Q S E +T
Sbjct: 469 EQEMTRLHRRVSEVEAVL------SQKEVELKASETQRSLLEQDLATYITECSSLKRSLE 522
Query: 140 QASSVNGTDDEKASHAGPANTH-LKSENDKLK-IALTQSAANVKKWEIELQTLRES--NA 195
QA +D+KA H ++ ++ KL+ I + A V++ + + L E +A
Sbjct: 523 QARMEVSQEDDKALQL----LHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSA 578
Query: 196 R-----LTTALQESAASVEQWKRQFSICRDE---------------------NDRLRNKI 229
R + L+ES + E++KR+ + C+ + N + KI
Sbjct: 579 RRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKI 638
Query: 230 DELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSE 289
EL+E+ + + + T+L + I + + + +L++ SE I + + E E + E
Sbjct: 639 QELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEE 698
Query: 290 KLEAAERDNQNLEDKVRSLKTDIEES-KYRQRHLKVEL 326
K A+ Q+LE ++ + EE K +K +L
Sbjct: 699 KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDL 736
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 57.8 bits (138), Expect = 1e-08
Identities = 62/250 (24%), Positives = 109/250 (43%), Gaps = 31/250 (12%)
Query: 115 DKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALT 174
D+T K+ QE+ ++T Q +++K + A T L+ + D L+ +L
Sbjct: 990 DETIAKLTKEKKALQEAHQQTLDDLQM------EEDKVNTLTKAKTKLEQQVDDLEGSLE 1043
Query: 175 QSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEE 234
Q KK ++L+ + QES E K+Q N++L+ K E+
Sbjct: 1044 QE----KKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQL------NEKLKKKEFEMSN 1093
Query: 235 QCSEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQSEIIPQLMSECEYVSEK 290
+I E+ QL+++I+EL+A + E E E++ R K + L E E +SE+
Sbjct: 1094 LQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1153
Query: 291 LEAAE-------RDNQNLEDKVRSLKTDIEESKYRQRHLKVELK----SFLEVLDGKIDD 339
LE A N+ E + + ++ D+EES + L+ + L +ID
Sbjct: 1154 LEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDS 1213
Query: 340 LHDFRRGLSK 349
L ++ L K
Sbjct: 1214 LQRVKQKLEK 1223
Score = 52.4 bits (124), Expect = 6e-07
Identities = 47/236 (19%), Positives = 111/236 (47%), Gaps = 11/236 (4%)
Query: 96 LTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA 155
L K F +V K ++TQ ++E S S+ ST+ V +E H
Sbjct: 1446 LDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSL------STELFKVKNAYEESLDHL 1499
Query: 156 GPA---NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWK 212
N +L+ E L + + ++ + E + L + L T+L+E+ AS+E +
Sbjct: 1500 ETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEE 1559
Query: 213 RQFSICRDENDRLRNKID-ELEEQCSEINREKEKNTQLKRRIEE-LEAELREKETELKDL 270
+ + E ++++++ID ++ E+ E+++ K + ++ ++ L+AE+R + L+
Sbjct: 1560 GKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIK 1619
Query: 271 RKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 326
+K + ++ + + + + A R+ +N + ++ + ++++ Q LK +L
Sbjct: 1620 KKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQL 1675
Score = 50.8 bits (120), Expect = 2e-06
Identities = 56/243 (23%), Positives = 104/243 (42%), Gaps = 36/243 (14%)
Query: 129 QESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQ--SAAN--VKKWE 184
+E R+ T+A S + A H E + K L + S AN V +W
Sbjct: 1317 EELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR 1376
Query: 185 IELQT--------LRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQC 236
+ +T L E+ +L LQ++ VE + + RL+N++++L
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDV 1436
Query: 237 SEINR------EKEKN-----TQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECE 285
N +K++N + K++ EE +AEL E K+ R S + ++ + E
Sbjct: 1437 ERSNAACIALDKKQRNFDKVLAEWKQKYEETQAEL---EASQKESRSLSTELFKVKNAYE 1493
Query: 286 YVSEKLEAAERDNQNLEDKVRSLKT----------DIEESKYRQRHLKVELKSFLEVLDG 335
+ LE +R+N+NL+ ++ L ++E+ K + H K EL++ LE +
Sbjct: 1494 ESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEA 1553
Query: 336 KID 338
++
Sbjct: 1554 SLE 1556
Score = 50.1 bits (118), Expect = 3e-06
Identities = 50/261 (19%), Positives = 111/261 (42%), Gaps = 26/261 (9%)
Query: 93 EQQLTKFAEK------FQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNG 146
E+ +T EK Q +A A+++ + I+T + T + +N
Sbjct: 879 EKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINA 938
Query: 147 TDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAA 206
K + LK + D L++ L + E +++ L E A L E+ A
Sbjct: 939 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA----GLDETIA 994
Query: 207 SVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETE 266
+ + K+ + +D+L+ + ++N + T+L++++++LE L +++
Sbjct: 995 KLTKEKKALQEAHQQT------LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKL 1048
Query: 267 LKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYR-----QRH 321
DL + +L + + E E D Q L +K++ K + E S + ++
Sbjct: 1049 CMDLERAKR---KLEGDLKLAQESTMDTENDKQQLNEKLK--KKEFEMSNLQGKIEDEQA 1103
Query: 322 LKVELKSFLEVLDGKIDDLHD 342
L ++L+ ++ L +I++L +
Sbjct: 1104 LAIQLQKKIKELQARIEELEE 1124
Score = 45.1 bits (105), Expect = 1e-04
Identities = 47/208 (22%), Positives = 94/208 (45%), Gaps = 33/208 (15%)
Query: 159 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 218
NT L + KL+ ++Q + E +Q R + + A+ ++A E+ K++
Sbjct: 1724 NTSLINTKKKLETDISQIQGEM---EDIVQEARNAEEKAKKAITDAAMMAEELKKE---- 1776
Query: 219 RDENDRLRNKIDELEEQCSEINREKEKNTQL-----KRRIEELEAELREKETELKDLRKQ 273
+D + L +E+ ++ ++ QL K++I++LEA +RE E+E++ +K
Sbjct: 1777 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKH 1836
Query: 274 S-EIIPQLMSECEYVSEKLEAAERDNQN----------LEDKVRSLKTDIEE-------- 314
+ E + L V E E D +N L+ KV++ K EE
Sbjct: 1837 NVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVN 1896
Query: 315 -SKYRQ-RHLKVELKSFLEVLDGKIDDL 340
+K+R+ +H E K ++ + +++ L
Sbjct: 1897 LAKFRKLQHELEEAKERADIAESQVNKL 1924
Score = 41.6 bits (96), Expect = 0.001
Identities = 41/200 (20%), Positives = 88/200 (44%), Gaps = 13/200 (6%)
Query: 151 KASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQ 210
K++ ++K E +K K L ++ A K+ E ++ TL + L +Q A ++
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 211 WKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDL 270
+ D+L +LE + E+ E ++ EL A+ R+ E E +L
Sbjct: 905 -------AEERCDQLIKTKIQLEAKIKEVTERAEDEEEIN---AELTAKKRKLEDECSEL 954
Query: 271 RKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFL 330
+K + + +++ V ++ A E +NL +++ L I + ++ L+ + L
Sbjct: 955 KKDIDDLELTLAK---VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 331 EVLDGKIDDLHDFRRGLSKL 350
+ L + D ++ + +KL
Sbjct: 1012 DDLQMEEDKVNTLTKAKTKL 1031
Score = 41.2 bits (95), Expect = 0.001
Identities = 62/299 (20%), Positives = 123/299 (41%), Gaps = 33/299 (11%)
Query: 76 QWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRET 135
Q + + NT+ EQQ+ ++ K+ + ++ + K+E +QES +T
Sbjct: 1015 QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLC-MDLERAKRKLEGDLKLAQESTMDT 1073
Query: 136 PSSTQASSVNGTDDEKASHAGPANTHLKSENDK-----LKIALTQSAANVKKWEIELQTL 190
+ Q + + K +N K E+++ L+ + + A +++ E E++
Sbjct: 1074 ENDKQQLN----EKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAE 1129
Query: 191 RESNAR-------LTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREK 243
R S A+ L+ L+E + +E+ S + N + + ++ E +
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQH 1189
Query: 244 EKNTQ-LKRRIEELEAELREKETELKDLRKQSEI--------IPQLMSECEYVSEKLEAA 294
E L+++ + AEL E+ L+ ++++ E I L S E VS+
Sbjct: 1190 EATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANF 1249
Query: 295 ERDNQNLEDKVRSLKTDIEESK-------YRQRHLKVELKSFLEVLDGKIDDLHDFRRG 346
E+ + LED++ +KT EE + ++ L E F LD K + RG
Sbjct: 1250 EKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRG 1308
Score = 40.8 bits (94), Expect = 0.002
Identities = 36/166 (21%), Positives = 78/166 (46%), Gaps = 20/166 (12%)
Query: 191 RESNARLTTALQESAASVEQWKRQF---SICRDEN-----DRLRNKIDELEEQCSEINRE 242
+E+ A L + ++ + V QW+ ++ +I R E +L ++ + EE +N +
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 243 ----KEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSEC----EYVSEKLEAA 294
++ +L+ +E+L ++ L K+ ++++E E +LEA+
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEAS 1474
Query: 295 ERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 340
++++++L ++ +K EES LK E K+ L +I DL
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKN----LQQEISDL 1516
Score = 38.1 bits (87), Expect = 0.012
Identities = 44/184 (23%), Positives = 79/184 (42%), Gaps = 27/184 (14%)
Query: 159 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 218
+ ++S ND L+I KK E +L E +L A +++A ++ + I
Sbjct: 1606 DAEIRSRNDALRIK--------KKMEGDLN---EMEIQLNHANRQAAEALRNLRNTQGIL 1654
Query: 219 RDENDRLRNKI---DELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSE 275
+D L + I D+L+EQ + + R + ++ +EEL A L E RK +E
Sbjct: 1655 KDTQLHLDDAIRGQDDLKEQLAMVER---RANLMQAEVEELRASLERTERG----RKMAE 1707
Query: 276 IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG 335
E SE+++ N +L + + L+TDI + + + E ++ E
Sbjct: 1708 ------QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKK 1761
Query: 336 KIDD 339
I D
Sbjct: 1762 AITD 1765
Score = 37.4 bits (85), Expect = 0.021
Identities = 46/243 (18%), Positives = 93/243 (38%), Gaps = 23/243 (9%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEK 151
+E+Q + + + +E+ E + A T +IE + E + ++
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR---------RDLEEST 1186
Query: 152 ASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVE-- 209
H A K D ++ + + + Q L + + L + + A+++E
Sbjct: 1187 LQHEATAAALRKKHAD----SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETV 1242
Query: 210 -QWKRQFS-ICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETEL 267
+ K F +CR D+L + EEQ IN + +L E +L EK+ +
Sbjct: 1243 SKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMV 1302
Query: 268 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD---IEESKYRQRHLKV 324
L + + Q + E + +LE + L ++S + D + E ++ K
Sbjct: 1303 SQLSRGKQAFTQ---QIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA 1359
Query: 325 ELK 327
EL+
Sbjct: 1360 ELQ 1362
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 57.4 bits (137), Expect = 2e-08
Identities = 63/253 (24%), Positives = 116/253 (45%), Gaps = 37/253 (14%)
Query: 115 DKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALT 174
D+ K+ QE+ ++ QA +++K + A L+ + D L+ +L
Sbjct: 986 DEIIAKLTKEKKALQEAHQQALDDLQA------EEDKVNTLTKAKVKLEQQVDDLEGSLE 1039
Query: 175 QSAANVKKWEIELQTLR---ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE 231
Q KK ++L+ + E + +LT QES +E K+Q ++RL+ K E
Sbjct: 1040 QE----KKVRMDLERAKRKLEGDLKLT---QESIMDLENDKQQL------DERLKKKDFE 1086
Query: 232 LEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQSEIIPQLMSECEYV 287
L + I E+ +QL+++++EL+A + E E EL+ R K ++ L E E +
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146
Query: 288 SEKLEAAE-------RDNQNLEDKVRSLKTDIEESKYRQRHLKVELK----SFLEVLDGK 336
SE+LE A N+ E + + ++ D+EE+ + L+ + L +
Sbjct: 1147 SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1206
Query: 337 IDDLHDFRRGLSK 349
ID+L ++ L K
Sbjct: 1207 IDNLQRVKQKLEK 1219
Score = 55.8 bits (133), Expect = 6e-08
Identities = 74/336 (22%), Positives = 144/336 (42%), Gaps = 49/336 (14%)
Query: 39 DVTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTK 98
DVT N +II + T+ M ++ A+ +V L + T+
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK------AEETQRSVNDLTSQRAKLQTE 1283
Query: 99 FAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASH---- 154
E +++ E + T+ K+ T + ++ R+ +A + + A H
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKL-TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL 1342
Query: 155 ---AGPANTHLKSENDKLKIALTQSAANVKKWEIELQT--------LRESNARLTTALQE 203
T K+E L+ L+++ + V +W + +T L E+ +L LQE
Sbjct: 1343 LREQYEEETEAKAE---LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1399
Query: 204 SAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINR------EKEKN-----TQLKRR 252
+ +VE + S RL+N+I++L N +K++N + K++
Sbjct: 1400 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1459
Query: 253 IEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL---- 308
EE ++EL E+ K+ R S + +L + E E LE +R+N+NL++++ L
Sbjct: 1460 YEESQSEL---ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 309 ----KT--DIEESKYRQRHLKVELKSFLEVLDGKID 338
KT ++E+ + + K+EL+S LE + ++
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLE 1552
Score = 47.4 bits (111), Expect = 2e-05
Identities = 53/208 (25%), Positives = 103/208 (49%), Gaps = 32/208 (15%)
Query: 162 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARL---TTALQESAASVEQWKRQF--- 215
+K E +LK AL +S A K+ E ++ +L + L A Q++ A E+ Q
Sbjct: 852 MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKN 911
Query: 216 -----SICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAEL----REK--- 263
+ ++ N+RL ++ + E ++ + +++ ++LKR I++LE L +EK
Sbjct: 912 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHAT 971
Query: 264 ETELKDLRKQ----SEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLK---------- 309
E ++K+L ++ EII +L E + + E + A D Q EDKV +L
Sbjct: 972 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 310 TDIEESKYRQRHLKVELKSFLEVLDGKI 337
D+E S +++ ++++L+ L+G +
Sbjct: 1032 DDLEGSLEQEKKVRMDLERAKRKLEGDL 1059
Score = 45.4 bits (106), Expect = 8e-05
Identities = 45/219 (20%), Positives = 98/219 (44%), Gaps = 33/219 (15%)
Query: 159 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 218
NT L ++ K+ L+Q V++ +Q R + + A+ ++A E+ K++
Sbjct: 1720 NTSLINQKKKMDADLSQLQTEVEE---AVQECRNAEEKAKKAITDAAMMAEELKKE---- 1772
Query: 219 RDENDRLRNKIDELEEQCSEINREKEKNTQL-----KRRIEELEAELREKETELK-DLRK 272
+D + L +E+ ++ ++ Q+ K+++++LEA +RE E EL+ + ++
Sbjct: 1773 QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKR 1832
Query: 273 QSEIIPQLMSECEYVSEKLEAAERDNQNL----------EDKVRSLKTDIEE-------- 314
+E + + + E E D +NL + KV++ K EE
Sbjct: 1833 NAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTN 1892
Query: 315 -SKYRQ-RHLKVELKSFLEVLDGKIDDLHDFRRGLSKLG 351
SK+R+ +H E + ++ + +++ L R + G
Sbjct: 1893 LSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKG 1931
Score = 43.1 bits (100), Expect = 4e-04
Identities = 60/257 (23%), Positives = 111/257 (43%), Gaps = 19/257 (7%)
Query: 98 KFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDE-KASHAG 156
K AEK +E+ E AK + + ++TS + S E + + + E + SHA
Sbjct: 1575 KLAEKDEEM-EQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 157 ----PANTHLKSENDKLK---IALTQSAANVKKWEIELQTLRESNARLTTALQESAASVE 209
A +KS LK I L + + + + N L L+E A VE
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693
Query: 210 QWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKN----TQLKRRIEELEAELREKET 265
Q +R + E ++ L Q + + +K+K +QL+ +EE E R E
Sbjct: 1694 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753
Query: 266 ELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE 325
+ K + ++ + + + + S LE R +N+E ++ L+ ++E++ Q LK
Sbjct: 1754 KAKKAITDAAMMAEELKKEQDTSAHLE---RMKKNMEQTIKDLQHRLDEAE--QIALKGG 1808
Query: 326 LKSFLEVLDGKIDDLHD 342
K L+ L+ ++ +L +
Sbjct: 1809 KKQ-LQKLEARVRELEN 1824
Score = 41.6 bits (96), Expect = 0.001
Identities = 44/234 (18%), Positives = 96/234 (41%), Gaps = 21/234 (8%)
Query: 105 EVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKS 164
E AA A DK Q + ++ E+ S ++S L +
Sbjct: 1433 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS-------------LST 1479
Query: 165 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 224
E KLK A +S +++ ++ E + L+E + LT L S ++ + ++ E
Sbjct: 1480 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKME 1539
Query: 225 LRNKIDELEEQCSEINREKEKNTQLKRRIEELEAE----LREKETELKDL-RKQSEIIPQ 279
L++ ++E E + + E+ K + + +++AE L EK+ E++ R ++
Sbjct: 1540 LQSALEEAE---ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS 1596
Query: 280 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL 333
L + + + A R + +E + ++ + + + ++KS +L
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1650
Score = 30.4 bits (67), Expect = 2.5
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 6/113 (5%)
Query: 231 ELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEK 290
E+ E R KE + + R +ELE ++ E DL+ Q + +++ E E+
Sbjct: 848 EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAE---ER 904
Query: 291 LEAAERDNQNLEDKVRSLKTDIEESKYRQRHL---KVELKSFLEVLDGKIDDL 340
+ ++ LE KV+ + +E+ + L K +L+ L IDDL
Sbjct: 905 CDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL 957
>gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo
sapiens]
Length = 1185
Score = 57.0 bits (136), Expect = 3e-08
Identities = 60/238 (25%), Positives = 107/238 (44%), Gaps = 43/238 (18%)
Query: 107 KEAAKIAKDKTQEKIETSS----NHSQESGRETPSSTQASSVNGT-----DDEKASHAGP 157
KE + + Q+K T NH QE+ TPS++ S +G+ D K
Sbjct: 201 KELMILKEQNNQKKTLTDGVLDINHEQEN---TPSTSGKRSSDGSLSHEEDLAKVIELQE 257
Query: 158 ANTHLKSENDKLKIALTQSAANVKKWEIELQTLR-------ESNARLTTALQESAASVEQ 210
+ E ++K L +++V + E +L T R E N +L ++E+ A E
Sbjct: 258 IISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKED 317
Query: 211 WK--------------RQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL 256
+ R+ + D ND+L N E+ + S + ++KN QL+ R+E
Sbjct: 318 MEERITTLEKRYLAAQREATSVHDLNDKLEN---EIANKDSMHRQTEDKNRQLQERLELA 374
Query: 257 EAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEE 314
E +L++ LRK +E +P++ +E L AE + N+E+++R ++ +EE
Sbjct: 375 EQKLQQT------LRK-AETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEE 425
>gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo
sapiens]
Length = 1202
Score = 57.0 bits (136), Expect = 3e-08
Identities = 60/238 (25%), Positives = 107/238 (44%), Gaps = 43/238 (18%)
Query: 107 KEAAKIAKDKTQEKIETSS----NHSQESGRETPSSTQASSVNGT-----DDEKASHAGP 157
KE + + Q+K T NH QE+ TPS++ S +G+ D K
Sbjct: 201 KELMILKEQNNQKKTLTDGVLDINHEQEN---TPSTSGKRSSDGSLSHEEDLAKVIELQE 257
Query: 158 ANTHLKSENDKLKIALTQSAANVKKWEIELQTLR-------ESNARLTTALQESAASVEQ 210
+ E ++K L +++V + E +L T R E N +L ++E+ A E
Sbjct: 258 IISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKED 317
Query: 211 WK--------------RQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL 256
+ R+ + D ND+L N E+ + S + ++KN QL+ R+E
Sbjct: 318 MEERITTLEKRYLAAQREATSVHDLNDKLEN---EIANKDSMHRQTEDKNRQLQERLELA 374
Query: 257 EAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEE 314
E +L++ LRK +E +P++ +E L AE + N+E+++R ++ +EE
Sbjct: 375 EQKLQQT------LRK-AETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEE 425
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,728,534
Number of Sequences: 37866
Number of extensions: 493404
Number of successful extensions: 11100
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 482
Number of HSP's successfully gapped in prelim test: 931
Number of HSP's that attempted gapping in prelim test: 4053
Number of HSP's gapped (non-prelim): 4503
length of query: 354
length of database: 18,247,518
effective HSP length: 103
effective length of query: 251
effective length of database: 14,347,320
effective search space: 3601177320
effective search space used: 3601177320
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.