Search of human proteins with 126032338

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|126032338 ryanodine receptor 3 [Homo sapiens]
         (4870 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|126032338 ryanodine receptor 3 [Homo sapiens]                     9806   0.0  
gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]        4946   0.0  
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ...  4771   0.0  
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ...  4762   0.0  
gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo s...   167   2e-40
gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isofor...   164   3e-39
gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isofor...   164   3e-39
gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo ...   160   3e-38
gi|37588869 ring finger protein 123 [Homo sapiens]                     77   4e-13
gi|45387949 ring finger and SPRY domain containing 1 [Homo sapiens]    63   8e-09
gi|157412282 ash2-like isoform b [Homo sapiens]                        51   2e-05
gi|157412280 ash2-like isoform a [Homo sapiens]                        51   2e-05
gi|40538736 RAN binding protein 10 [Homo sapiens]                      46   8e-04
gi|39812378 RAN binding protein 9 [Homo sapiens]                       45   0.001
gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2 [H...    45   0.001
gi|4826686 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [Homo sapiens]     44   0.003
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    43   0.009
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    43   0.009
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          41   0.025
gi|221219020 NYD-SP11 protein [Homo sapiens]                           40   0.043
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         40   0.057
gi|55956788 nucleolin [Homo sapiens]                                   39   0.097
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi...    39   0.097
gi|169167243 PREDICTED: similar to myosin regulatory light chain...    39   0.13 
gi|190014636 hypothetical protein LOC286262 isoform 2 [Homo sapi...    39   0.13 
gi|190014638 hypothetical protein LOC286262 isoform 1 [Homo sapi...    39   0.13 
gi|88981341 PREDICTED: similar to myosin regulatory light chain ...    39   0.16 
gi|51464364 PREDICTED: similar to myosin regulatory light chain ...    39   0.16 
gi|51873049 hypothetical protein LOC8603 [Homo sapiens]                39   0.16 
gi|55770834 centromere protein F [Homo sapiens]                        39   0.16 

>gi|126032338 ryanodine receptor 3 [Homo sapiens]
          Length = 4870

 Score = 9806 bits (25445), Expect = 0.0
 Identities = 4870/4870 (100%), Positives = 4870/4870 (100%)

Query: 1    MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP 60
            MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP
Sbjct: 1    MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP 60

Query: 61   PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYL 120
            PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYL
Sbjct: 61   PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYL 120

Query: 121  TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER 180
            TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER
Sbjct: 121  TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER 180

Query: 181  YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD 240
            YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD
Sbjct: 181  YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD 240

Query: 241  QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED 300
            QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED
Sbjct: 241  QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED 300

Query: 301  QGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS 360
            QGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS
Sbjct: 301  QGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS 360

Query: 361  GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ 420
            GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ
Sbjct: 361  GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ 420

Query: 421  FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG 480
            FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG
Sbjct: 421  FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG 480

Query: 481  MLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN 540
            MLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN
Sbjct: 481  MLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN 540

Query: 541  NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI 600
            NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI
Sbjct: 541  NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI 600

Query: 601  LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW 660
            LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW
Sbjct: 601  LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW 660

Query: 661  YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW 720
            YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW
Sbjct: 661  YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW 720

Query: 721  SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS 780
            SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS
Sbjct: 721  SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS 780

Query: 781  FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGIRDLLGT 840
            FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGIRDLLGT
Sbjct: 781  FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGIRDLLGT 840

Query: 841  TQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR 900
            TQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR
Sbjct: 841  TQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR 900

Query: 901  QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS 960
            QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS
Sbjct: 901  QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS 960

Query: 961  NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV 1020
            NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV
Sbjct: 961  NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV 1020

Query: 1021 PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSY 1080
            PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSY
Sbjct: 1021 PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSY 1080

Query: 1081 AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQGSGYFGR 1140
            AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQGSGYFGR
Sbjct: 1081 AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQGSGYFGR 1140

Query: 1141 TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR 1200
            TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR
Sbjct: 1141 TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR 1200

Query: 1201 MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID 1260
            MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID
Sbjct: 1201 MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID 1260

Query: 1261 GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI 1320
            GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI
Sbjct: 1261 GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI 1320

Query: 1321 LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE 1380
            LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE
Sbjct: 1321 LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE 1380

Query: 1381 SVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPN 1440
            SVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPN
Sbjct: 1381 SVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPN 1440

Query: 1441 TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPVLW 1500
            TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPVLW
Sbjct: 1441 TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPVLW 1500

Query: 1501 SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH 1560
            SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH
Sbjct: 1501 SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH 1560

Query: 1561 TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE 1620
            TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE
Sbjct: 1561 TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE 1620

Query: 1621 RKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEDHQ 1680
            RKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEDHQ
Sbjct: 1621 RKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEDHQ 1680

Query: 1681 KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD 1740
            KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD
Sbjct: 1681 KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD 1740

Query: 1741 DDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP 1800
            DDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP
Sbjct: 1741 DDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP 1800

Query: 1801 ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA 1860
            ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA
Sbjct: 1801 ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA 1860

Query: 1861 RKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED 1920
            RKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED
Sbjct: 1861 RKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED 1920

Query: 1921 TSWTGKLCALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVR 1980
            TSWTGKLCALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVR
Sbjct: 1921 TSWTGKLCALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVR 1980

Query: 1981 MMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLM 2040
            MMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLM
Sbjct: 1981 MMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLM 2040

Query: 2041 INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF 2100
            INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF
Sbjct: 2041 INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF 2100

Query: 2101 CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLE 2160
            CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLE
Sbjct: 2101 CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLE 2160

Query: 2161 KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL 2220
            KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL
Sbjct: 2161 KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL 2220

Query: 2221 LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTGDDEEEEEIVH 2280
            LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTGDDEEEEEIVH
Sbjct: 2221 LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTGDDEEEEEIVH 2280

Query: 2281 MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP 2340
            MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP
Sbjct: 2281 MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP 2340

Query: 2341 SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD 2400
            SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD
Sbjct: 2341 SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD 2400

Query: 2401 TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTK 2460
            TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTK
Sbjct: 2401 TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTK 2460

Query: 2461 AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL 2520
            AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL
Sbjct: 2461 AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL 2520

Query: 2521 PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT 2580
            PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT
Sbjct: 2521 PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT 2580

Query: 2581 RITATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKY 2640
            RITATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKY
Sbjct: 2581 RITATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKY 2640

Query: 2641 GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE 2700
            GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE
Sbjct: 2641 GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE 2700

Query: 2701 NEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG 2760
            NEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG
Sbjct: 2701 NEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG 2760

Query: 2761 GSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKF 2820
            GSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKF
Sbjct: 2761 GSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKF 2820

Query: 2821 LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLS 2880
            LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLS
Sbjct: 2821 LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLS 2880

Query: 2881 SPLKPLSSSGYASHKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT 2940
            SPLKPLSSSGYASHKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT
Sbjct: 2881 SPLKPLSSSGYASHKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT 2940

Query: 2941 VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI 3000
            VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI
Sbjct: 2941 VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI 3000

Query: 3001 LTSIFEHVTQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA 3060
            LTSIFEHVTQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA
Sbjct: 3001 LTSIFEHVTQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA 3060

Query: 3061 AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAES 3120
            AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAES
Sbjct: 3061 AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAES 3120

Query: 3121 GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKII 3180
            GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKII
Sbjct: 3121 GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKII 3180

Query: 3181 NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADG 3240
            NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADG
Sbjct: 3181 NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADG 3240

Query: 3241 KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI 3300
            KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI
Sbjct: 3241 KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI 3300

Query: 3301 LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY 3360
            LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY
Sbjct: 3301 LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY 3360

Query: 3361 SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKS 3420
            SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKS
Sbjct: 3361 SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKS 3420

Query: 3421 DDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS 3480
            DDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS
Sbjct: 3421 DDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS 3480

Query: 3481 KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEE 3540
            KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEE
Sbjct: 3481 KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEE 3540

Query: 3541 EEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDK 3600
            EEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDK
Sbjct: 3541 EEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDK 3600

Query: 3601 EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN 3660
            EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN
Sbjct: 3601 EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN 3660

Query: 3661 AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE 3720
            AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE
Sbjct: 3661 AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE 3720

Query: 3721 RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES 3780
            RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES
Sbjct: 3721 RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES 3780

Query: 3781 ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV 3840
            ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV
Sbjct: 3781 ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV 3840

Query: 3841 VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV 3900
            VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV
Sbjct: 3841 VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV 3900

Query: 3901 ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEID 3960
            ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEID
Sbjct: 3901 ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEID 3960

Query: 3961 FLLSCAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES 4020
            FLLSCAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES
Sbjct: 3961 FLLSCAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES 4020

Query: 4021 VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE 4080
            VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE
Sbjct: 4021 VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE 4080

Query: 4081 KMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLEPAS 4140
            KMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLEPAS
Sbjct: 4081 KMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLEPAS 4140

Query: 4141 AFAMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLF 4200
            AFAMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLF
Sbjct: 4141 AFAMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLF 4200

Query: 4201 TILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGI 4260
            TILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGI
Sbjct: 4201 TILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGI 4260

Query: 4261 TTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQ 4320
            TTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQ
Sbjct: 4261 TTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQ 4320

Query: 4321 KKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQK 4380
            KKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQK
Sbjct: 4321 KKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQK 4380

Query: 4381 VEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEE 4440
            VEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEE
Sbjct: 4381 VEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEE 4440

Query: 4441 ETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKV 4500
            ETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKV
Sbjct: 4441 ETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKV 4500

Query: 4501 PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN 4560
            PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN
Sbjct: 4501 PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN 4560

Query: 4561 KYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDN 4620
            KYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDN
Sbjct: 4561 KYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDN 4620

Query: 4621 SFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV 4680
            SFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV
Sbjct: 4621 SFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV 4680

Query: 4681 VYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD 4740
            VYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD
Sbjct: 4681 VYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD 4740

Query: 4741 PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY 4800
            PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY
Sbjct: 4741 PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY 4800

Query: 4801 FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC 4860
            FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC
Sbjct: 4801 FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC 4860

Query: 4861 FRKQYEDQLG 4870
            FRKQYEDQLG
Sbjct: 4861 FRKQYEDQLG 4870


>gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]
          Length = 4967

 Score = 4946 bits (12829), Expect = 0.0
 Identities = 2469/3613 (68%), Positives = 2939/3613 (81%), Gaps = 86/3613 (2%)

Query: 1299 SFSHSPCLDSEAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEK 1358
            S SHS  L  +     +   + L  T+T  YY++RIF GQ+P+ VWVGW+T D+H Y   
Sbjct: 1398 STSHSARLTEDVLADDRDDYDFLMQTSTY-YYSVRIFPGQEPANVWVGWITSDFHQYDTG 1456

Query: 1359 FDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLA 1418
            FDL++  TVTVTLGDE+G+VHES+KRSNCYMV  G+ ++  Q   R+N  LEIGC+VD A
Sbjct: 1457 FDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQ--GRNNNGLEIGCVVDAA 1514

Query: 1419 MGMLSFSANGKELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSE 1478
             G+L+F ANGKEL T YQVEP+TK+FPAVF Q TS ++FQFELG++KN MPLSA +F+SE
Sbjct: 1515 SGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSE 1574

Query: 1479 EKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPE 1538
             KNPVPQCPPRL VQ +  VLWSRMPN FLKV+  R+SER GW+VQCL+PLQ M+LHIPE
Sbjct: 1575 HKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPE 1634

Query: 1539 ENRCVDILELCEQEDLMRFHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYL 1598
            ENR VDILEL EQE+L++FHYHTLRLYSAVCALGN RVA+ALCSHVD  QL YAI+NKY+
Sbjct: 1635 ENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYM 1694

Query: 1599 PGLLRSGFYDLLISIHLASAKERKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLR 1658
            PGLLR+G+YDLLI IHL+S    +LMM NEYI+P+T  T++I LFPDE+K+HGLPG+GL 
Sbjct: 1695 PGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFPDENKKHGLPGIGLS 1754

Query: 1659 TCLKPGFRFSTPCFVVTGEDHQKQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSV 1718
            T L+P  +FS+P FV    +  + SPE PL+ L++K + MLTEAV+    H RDPVGG+ 
Sbjct: 1755 TSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTT 1814

Query: 1719 EFQFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKA 1778
            EF FVP++KL  TLL+MG+F ++D++ IL LI+PSVF E +   EE    E+   V++  
Sbjct: 1815 EFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVDDAK 1874

Query: 1779 VE-AGEKAGK--EAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVS 1835
            ++ AGE+  K  + P +GLLQ +LPE VKLQMC LL YLCDC+++HR+EAIVAF D +V+
Sbjct: 1875 LQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVA 1934

Query: 1836 KLQANQKFRYNELMQALNMSAALTARKTKEFRSPPQEQINMLLNFQLGEN-CPCPEEIRE 1894
            KLQ NQ+FRYNE+MQALNMSAALTARKTKEFRSPPQEQINMLLNF+  ++ CPCPEEIR+
Sbjct: 1935 KLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRD 1994

Query: 1895 ELYDFHEDLLLHCGVPLEEEEEEEEDTSWT--GKLCALVYKIKGPPKPEKEQPTEEEERC 1952
            +L DFHEDL+ HCG+ L+E+   + ++  T  G+L +LV K+    K + E+P E + + 
Sbjct: 1995 QLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKK 2054

Query: 1953 PTTLKELISQTMICWAQEDQIQDSELVRMMFNLLRRQYDSIGELLQALRKTYTISHTSVS 2012
             +TL++LIS+TM+ WAQE  I+D ELVR MF LL RQYD IG L++AL KTYTI+  SV 
Sbjct: 2055 SSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVE 2114

Query: 2013 DTINLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEV 2072
            DTINLLA+LGQIRSLLSVRMGKEEE LMI GLGDIMNNKVFYQHPNLMR LGMHETVMEV
Sbjct: 2115 DTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEV 2174

Query: 2073 MVNVLGT-EKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSM 2131
            MVNVLG  E  +I FPKMVA+CCRFLCYFCRISRQNQKAMF+HLSYLLENSSVGLASP+M
Sbjct: 2175 MVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAM 2234

Query: 2132 RGSTPLDVAASSVMDNNELALSLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIE 2191
            RGSTPLDVAA+SVMDNNELAL+L EPDLEKVV YLAGCGLQSC ML++KGYPD+GWNP+E
Sbjct: 2235 RGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVE 2294

Query: 2192 GERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKIS 2251
            GERYL FLRFAVF N ESVEENA+VVV+LLIRRPECFGPALRGEGGNGLLAAM+ AIKI+
Sbjct: 2295 GERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIA 2354

Query: 2252 ENPALDLPSQGYKREVSTGDDEEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKG 2311
            E+P+ D PS       +   +EEE++ +HMGNAIM+FYSALIDLLGRCAPEMHLI  GKG
Sbjct: 2355 EDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKG 2414

Query: 2312 EAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDR 2371
            EAIRIRSILRSL+P  DLVG+ISI  ++P++ KDG+V EPDM+A FCPDHKA MVLFLDR
Sbjct: 2415 EAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDR 2474

Query: 2372 VYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPL 2431
            VYGI+ Q FLLHLLEVGFLPDLRA+ASLDT +LS T+ ALALNRY+C+AVLPLLTRCAPL
Sbjct: 2475 VYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPL 2534

Query: 2432 FAGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVF 2491
            FAGTEH  SLIDS L T+YRLSKG SLTKAQRD+IE CLL+IC  LRPSM+Q LLRRLVF
Sbjct: 2535 FAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVF 2594

Query: 2492 DVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSH 2551
            DVP LNE+ KMPLKLLTNHYE+CWKYYCLP GWG++G A EEELHL+ KLFWGIFD+LS 
Sbjct: 2595 DVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQ 2654

Query: 2552 KKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQISVDADGNFDPKPINTMNFSLP 2611
            KKY+ +LF++ALPCLSA+AGALPPDY+++   + +EKQ S+D++GNF+P+P++T N ++P
Sbjct: 2655 KKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIP 2714

Query: 2612 EKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWP 2671
            EKLEY + KYAEHSHDKW+ DK  +GW YG    ++ K  PL++P+K L+EKEKEIYRWP
Sbjct: 2715 EKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWP 2774

Query: 2672 ARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQ--ANQGNSYSPAPLDLSNVVLS 2729
             +ESLKTMLA GW +ERT+EG+++       ++   SQ   +  + YSP  +D+SNV LS
Sbjct: 2775 IKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLS 2834

Query: 2730 RELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFKDREKAQDLFK 2789
            R+L  M E++AENYHNIWAKKKK+ELESKGGG+HPLLVPYDTLTAKEK KDREKAQD+ K
Sbjct: 2835 RDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILK 2894

Query: 2790 FLQVNGIIVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEK 2849
            FLQ+NG  VSRG KD+ELD  S+EKRFAY FL+++++YVD A ++I   +   S GK E 
Sbjct: 2895 FLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDG-GSRGKGEH 2953

Query: 2850 SPRDQEIKFFAKVLLPLVDQYFTSHCLYFLSSPLKPLSSSGYASHKEKEMVAGLFCKLAA 2909
             P +QEIKFFAKV+LPL+DQYF +H LYFLS+  +PL S G+AS+KEKEMV  LFCKL  
Sbjct: 2954 FPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGV 3013

Query: 2910 LVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSE 2969
            LVRHRISLFG+D+T++V+CLHIL QTLD RTVMK+G E VK+ LRAF +NAAEDLEKT E
Sbjct: 3014 LVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTME 3073

Query: 2970 NLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVTQHQFGMDLLLGDVQISCYHI 3029
            NLK G+FTH+R Q KGV+Q INYTTVALLP+L+S+FEH+ QHQFG DL+L DVQ+SCY I
Sbjct: 3074 NLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRI 3133

Query: 3030 LCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERS 3089
            L SLY+LGT K+IYVERQR ALGECLA+ A A PVAFLE  L+++N  S++NTK+ RER+
Sbjct: 3134 LTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERA 3193

Query: 3090 ILGMPDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERG 3149
             L +P  VED+CP+IP LE LM+EI +LAESG RYT+MPHV+EVILPMLC+Y+S WWE G
Sbjct: 3194 ALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWEHG 3253

Query: 3150 PENLPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPD 3209
            PEN P     CCT + SEH++ +LGNILKII NNLGIDE +WMKR+AV++QPII+K +P 
Sbjct: 3254 PENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQ 3313

Query: 3210 LLRSHFIPTLEKLKKKAVKTVQEEEQLKADGKGDTQEAELLILDEFAVLCRDLYAFYPML 3269
            LL++HF+P +EKLKKKA   V EE+ LKA+ +GD  EAELLILDEF  L RDLYAFYP+L
Sbjct: 3314 LLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLL 3373

Query: 3270 IRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTG 3329
            IR+VD NR+ WLK P+ ++++LFRMVAEVFI W KSHNFKREEQNFV+QNEINN++FL  
Sbjct: 3374 IRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLIT 3433

Query: 3330 DSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQEL 3389
            D+KSKMSKA        DQERKK KR+GD YS+QTSLIVAALK++LPIGLN+C PGDQEL
Sbjct: 3434 DTKSKMSKA-----AVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQEL 3488

Query: 3390 ISLAKSRYSHRDTDEEVREHLRNNLHLQEKSDDPAVKWQLNLYKDV-LKSEEPFNPEKTV 3448
            I+LAK+R+S +DT++EVR+ +R+N+HLQ K +DPA++WQ+ LYKD+  ++++  +PEKTV
Sbjct: 3489 IALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDDTSDPEKTV 3548

Query: 3449 ERVQRISAAVFHLEQ------------VEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPL 3496
            ERV  I+  +FHLEQ            VE P RSKKAVWHKLLSKQRKRAVVACFRMAPL
Sbjct: 3549 ERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPL 3608

Query: 3497 YNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEETEKQPDPLHQI 3556
            YNLPRHR++NLFL GY++ WIETEE+ FE+KL++DLAK P  E  EE+E  K+ DPLHQ+
Sbjct: 3609 YNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAK-PGAEPPEEDEGTKRVDPLHQL 3667

Query: 3557 ILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLY 3616
            IL FSR ALTE+ KLE+D LY +Y+ +MAKSC   E++++ E++ K+FEEKEMEKQK LY
Sbjct: 3668 ILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHD-EEDDDGEEEVKSFEEKEMEKQKLLY 3726

Query: 3617 QQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKD 3676
            QQARLH+RGAAEMVLQ ISASKGE  PMV  TLKLGIAILNGGN+ VQQKMLDYLKEKKD
Sbjct: 3727 QQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKD 3786

Query: 3677 AGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLF 3736
             GFFQSL+GLMQSCSVLDLNAFERQNKAEGLGMVTEEG+      GEKVLQ+DEFT DLF
Sbjct: 3787 VGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGS------GEKVLQDDEFTCDLF 3840

Query: 3737 RFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDE 3796
            RFLQLLCEGHNSDFQN+LRTQ GN TTVN+IISTVDYLLR+QESISDFYWYYSGKD+IDE
Sbjct: 3841 RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE 3900

Query: 3797 SGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQ 3856
             GQ NFSKA+ V KQ+FN+LTEYIQGPC GNQQSLAHSRLWDAVVGFLHVFA+MQMKLSQ
Sbjct: 3901 QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ 3960

Query: 3857 DSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMF 3916
            DSSQIELLKEL+DL +DMVVMLLS+LEGNVVNGTIGKQMVD LVESS NVEMILKFFDMF
Sbjct: 3961 DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF 4020

Query: 3917 LKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNY 3976
            LKLKDLTSSDTFKEYDPDGKG+ISK++F KAME  K YTQSE +FLLSCAE DEN+  +Y
Sbjct: 4021 LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY 4080

Query: 3977 VDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMG 4036
             +FV RFHEPAKDIGFNVAVLLTNLSEHMPND+RL+  L+ AESVLNYF+P+LGRIEIMG
Sbjct: 4081 EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG 4140

Query: 4037 GAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEM 4096
             AK+IERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGE+EKMELFVNFCEDTIFEM
Sbjct: 4141 SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM 4200

Query: 4097 QLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLEPASAF------AMACASVK 4150
            QLA+QISESD  +R   +EE E            EE G   P  AF        A  +++
Sbjct: 4201 QLAAQISESDLNERSANKEESEKE--------RPEEQG---PRMAFFSILTVRSALFALR 4249

Query: 4151 RNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLFTILGGIFQIL 4210
             N+   ++  +LK+L+KQ + VKKMT K++V   FS +W +F+ L   + ++  G F+I+
Sbjct: 4250 YNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRII 4309

Query: 4211 WSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGITTELVHFIKG 4270
             S + GG LVEGAK I+V ++L +MPDPTQ  +  D  E ER + +E  + +E +  +K 
Sbjct: 4310 CSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGER-KPLEAALPSEDLTDLKE 4368

Query: 4271 EKGDTDIMSDLFGLHPKKEGS----LKHGPEVGLGDLSEIIGKDEPPTLESTVQKKRKAQ 4326
               ++D++SD+FGL  K+EG     + H P  GL DL        P  +    +K ++ +
Sbjct: 4369 LTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDL-----MSNPVPMPEVQEKFQEQK 4423

Query: 4327 AAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQKVEKPEA 4386
            A E +   + E K E EKA+ EDGEKE+K KE++  +        K ++    +  +PE 
Sbjct: 4424 AKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQ--------KLRQLHTHRYGEPEV 4475

Query: 4387 FTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVT--------EEPL 4438
              + F+K +  YQ KLL+Y ARNFYN+R LALFVAFAINFILLFYKV+        E P 
Sbjct: 4476 PESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPT 4535

Query: 4439 EEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCL 4498
               +E+      S +        V +VL+ES+GYM PTLR LAI+HT+IS  C++GYYCL
Sbjct: 4536 RSSSENAK--VTSLDSSSHRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCL 4593

Query: 4499 KVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKV 4558
            KVPLV+FKREKE+ARKLEFDGLYITEQPSEDDIKGQWDRLVINT SFPNNYWDKFVKRKV
Sbjct: 4594 KVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKV 4653

Query: 4559 INKYGDLYGAERIAELLGLDKNALDFSPVEETK--AEAASLVSWLSSIDMKYHIWKLGVV 4616
            ++KYG+ YG +RI+ELLG+DK ALDFS   E K   + +SL + L+SID+KY +WKLGVV
Sbjct: 4654 MDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVV 4713

Query: 4617 FTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL 4676
            FTDNSFLYLAWY TMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL
Sbjct: 4714 FTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL 4773

Query: 4677 LAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIED 4736
            LAVVVYLYTVVAFNFFRKFYNKSED D PDMKCDDM+TCY+FHMYVGVRAGGGIGDEIED
Sbjct: 4774 LAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIED 4833

Query: 4737 PAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGI 4796
            PAGD YE+YRI+FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQV+EDMETKCFICGI
Sbjct: 4834 PAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGI 4893

Query: 4797 GNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 4856
            GNDYFDT PHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCW+FFP
Sbjct: 4894 GNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP 4953

Query: 4857 AGDCFRKQYEDQL 4869
            AGDCFRKQYEDQL
Sbjct: 4954 AGDCFRKQYEDQL 4966



 Score = 1956 bits (5068), Expect = 0.0
 Identities = 920/1320 (69%), Positives = 1113/1320 (84%), Gaps = 24/1320 (1%)

Query: 1    MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP 60
            MA+GGEG EDEIQFLRT+DEVVLQC ATIHKEQ+K CLAAEG GNRLCFLE TS +K +P
Sbjct: 1    MADGGEG-EDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVP 59

Query: 61   PDLCVCNFVLEQSLSVRALQEMLANTGENGGEG------------AAQGGGHRTLLYGHA 108
            PDL +C FVLEQSLSVRALQEMLANT E   EG             AQGGGHRTLLYGHA
Sbjct: 60   PDLSICTFVLEQSLSVRALQEMLANTVEKS-EGQVDVEKWKFMMKTAQGGGHRTLLYGHA 118

Query: 109  VLLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIG 168
            +LLRHS+SGMYL CL+TSRS TDKLAFDVGL+E  TGEACWWTIHPASKQRSEGEKVR+G
Sbjct: 119  ILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVG 178

Query: 169  DDLILVSVSSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFH 228
            DDLILVSVSSERYLHLS  NG++ VDA+F QTLW+V P  SGS   +GYL+GG V+RL H
Sbjct: 179  DDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLH 238

Query: 229  GH-DECLTIPSTDQNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLR 287
            GH DECLT+PS +  + Q R + YE G     ARSLWR+E LR++WSGS+IRWGQ FRLR
Sbjct: 239  GHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLR 298

Query: 288  HLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIK 347
            H+TTG YL+L ED+ L+L D+ K+D KSTAF+FR+SKE   KLD   +++++GMG  EIK
Sbjct: 299  HVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKE---KLDVGVRKEVDGMGTSEIK 355

Query: 348  YGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQA 407
            YGDSVC++QH+ +GLW+TY++ D K+ R+G ++RK I+H EGHMDDG++L R Q EES+ 
Sbjct: 356  YGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRT 415

Query: 408  ARIIRNTTALFSQFVSG-----NNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDK 462
            AR+IR+T  LF++F+ G         A+ + LPIE V  +LQDLI YF PP+E + HEDK
Sbjct: 416  ARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDK 475

Query: 463  QNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYK 522
            QN+LR+LKNRQNLF+EEGM+ LVL CIDRL+VY+S AHFA +A  E+G +WK ILN LY+
Sbjct: 476  QNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYE 535

Query: 523  LLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIK 582
            LLAALIRGNR NCAQFS +LDWLIS+L+RLE+SSGILEVLHC+L ESPEALN+I EGHIK
Sbjct: 536  LLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIK 595

Query: 583  SIISLLDKHGRNHKVLDILCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSI 642
            SIISLLDKHGRNHKVLD+LCSLC+C+GVAVR+NQ+LICDNLLP R+LLLQTRL+N V+S+
Sbjct: 596  SIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSM 655

Query: 643  RPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGG 702
            RPNIFLGV+EGSAQYKKWY+EL++D  +PF+TAE THLRVGWAS+ GY+PYPGGGE WGG
Sbjct: 656  RPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGG 715

Query: 703  NGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPV 762
            NGVGDDL+SYGFDGLHLWSG I R V+S NQHLLR+DDV+SCCLDL  PSISFRINGQPV
Sbjct: 716  NGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPV 775

Query: 763  QGMFENFNTDGLFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLE 822
            QGMFENFN DGLFFPV+SFSAG+KVRFL+GGRHGEFKFLPP GYAPCYEA+LPKEK+++E
Sbjct: 776  QGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVE 835

Query: 823  PVKEYKRDADGIRDLLGTTQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGM 882
              +EYK++    RDLLG T  L+QA+F P PVDTSQ++LPPHLE+IR++LAENIHELW M
Sbjct: 836  HSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVM 895

Query: 883  NKIELGWTFGKIRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNP 942
            NKIELGW +G +RDDNKRQHPCLVEFSKLPE E+NYNLQMS ETLKTLLALGCH+   + 
Sbjct: 896  NKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDE 955

Query: 943  AAEEDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQG 1002
             AE+ +KK+KLPKNY +++GYKPAP+DLS +KL P QE +VDKLAENAHNVWA+DRI+QG
Sbjct: 956  HAEDKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQG 1015

Query: 1003 WTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSA 1062
            WTYGIQQD+KN+RNPRLVPY LLD+RTKKSN+DSLREAVRT +GYGYN+E  DQ+ A  A
Sbjct: 1016 WTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARA 1075

Query: 1063 -VEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAF 1121
             V   + ++ R FR E++YAV++G+WYFEFE VT GDMRVGW+RPGC+PD ELG+D++AF
Sbjct: 1076 EVCSGTGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAF 1135

Query: 1122 VFEGNRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADY 1181
             F+G + QRWHQG+ ++GR+WQ GDVVGCM+++++ +M+FTLNGE+L+ + GSELAF D+
Sbjct: 1136 AFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDF 1195

Query: 1182 EIENGFVPICCLGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRL 1241
            ++ +GF+P+C LG++Q+GRMN G D ST K++T+CGLQEG+EPFAVN NRD+ MW SKRL
Sbjct: 1196 DVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRL 1255

Query: 1242 PTFVNVPKDHPHIEVMRIDGTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFS 1301
            P F+ VP +H HIEV RIDGT+DS PCLKVT K+FG+QNSN D+++ RLSMP+EC   FS
Sbjct: 1256 PQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFS 1315



 Score =  108 bits (271), Expect = 1e-22
 Identities = 69/232 (29%), Positives = 116/232 (50%), Gaps = 20/232 (8%)

Query: 845  SQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPC 904
            S+ +F P PVDTS + +P  LE   ++ AE+ H+ W M+K+  GW +G+I  D+ +  P 
Sbjct: 2697 SEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPL 2756

Query: 905  LVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDL--KKVKLPKNYMMS-- 960
            +  +  L E EK        E+LKT+LA G  I          L  +  ++ +   +S  
Sbjct: 2757 MKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVD 2816

Query: 961  --NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNK---R 1015
              +GY P  +D+S+V L      + + +AEN HN+WAK +         + +L++K    
Sbjct: 2817 AAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKK---------KMELESKGGGN 2867

Query: 1016 NPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEP--SDQELADSAVEK 1065
            +P LVPY  L  + K  +R+  ++ ++     GY +     D EL   ++EK
Sbjct: 2868 HPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEK 2919



 Score =  106 bits (264), Expect = 6e-22
 Identities = 63/200 (31%), Positives = 105/200 (52%), Gaps = 10/200 (5%)

Query: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657
            F P P++T    LP  LE I  K AE+ H+ W  +K + GW+YG   D+N + HP +  F
Sbjct: 862  FTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEF 921

Query: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQANQGNSYS 2717
              L E+E+      + E+LKT+LA+G  V  + E      + + +K++        + Y 
Sbjct: 922  SKLPEQERNYNLQMSLETLKTLLALGCHVGISDEH----AEDKVKKMKLPKNYQLTSGYK 977

Query: 2718 PAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKG------GGSHPLLVPYDT 2771
            PAP+DLS + L+   + MV+ +AEN HN+WA+ +  +  + G         +P LVPY  
Sbjct: 978  PAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTL 1037

Query: 2772 LTAKEKFKDREKAQDLFKFL 2791
            L  + K  +++  ++  + L
Sbjct: 1038 LDDRTKKSNKDSLREAVRTL 1057



 Score = 62.4 bits (150), Expect = 1e-08
 Identities = 29/97 (29%), Positives = 53/97 (54%)

Query: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657
            + P P++     L    E +V K AE++H+ WA D+ + GW YGI  D   + +P + P+
Sbjct: 976  YKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPY 1035

Query: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEA 2694
              L ++ K+  +   RE+++T+L  G+ +E   +  A
Sbjct: 1036 TLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHA 1072



 Score = 41.2 bits (95), Expect = 0.025
 Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 8/88 (9%)

Query: 2715 SYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG-------GSHPLLV 2767
            +++P P+D S +VL   L+ + E +AEN H +W    K+EL  + G         HP LV
Sbjct: 861  AFTPIPVDTSQIVLPPHLERIREKLAENIHELWV-MNKIELGWQYGPVRDDNKRQHPCLV 919

Query: 2768 PYDTLTAKEKFKDREKAQDLFKFLQVNG 2795
             +  L  +E+  + + + +  K L   G
Sbjct: 920  EFSKLPEQERNYNLQMSLETLKTLLALG 947


>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
            sapiens]
          Length = 5038

 Score = 4771 bits (12374), Expect = 0.0
 Identities = 2379/3637 (65%), Positives = 2894/3637 (79%), Gaps = 109/3637 (2%)

Query: 1319 EILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRV 1378
            EI+ +TTT  YY++R+FAGQ+PSCVW GWVTPDYH +   FDL+K   VTVT+GDE+G V
Sbjct: 1424 EIILNTTTY-YYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNV 1482

Query: 1379 HESVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVE 1438
            H S+K SNCYMVWGGD V+  Q+   S+ DL IGCLVDLA G+++F+ANGKE  T +QVE
Sbjct: 1483 HSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVE 1542

Query: 1439 PNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPV 1498
            PNTK+FPAVF+ PT  ++ QFELGK KN MPLSAA+F+SE KNP PQCPPRL++Q + PV
Sbjct: 1543 PNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPV 1602

Query: 1499 LWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFH 1558
             WSRMPN FL+VET R  ER GW VQC EPL MMALHIPEENRC+DILEL E+ DL RFH
Sbjct: 1603 SWSRMPNHFLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFH 1662

Query: 1559 YHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASA 1618
             HTLRLY AVCALGN+RVA+ALCSHVD +QL +A+++ +LPG LR+G+YDLLISIHL SA
Sbjct: 1663 SHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESA 1722

Query: 1619 KERKLMMKNEYIIPITSTTRNIRLFP------DESKRHGLPGVGLRTCLKPGFRFSTPCF 1672
               +  M +EYI+P+T  TR I LFP      +   RHGLPGVG+ T L+P   FS PCF
Sbjct: 1723 CRSRRSMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCF 1782

Query: 1673 VVT------GEDHQKQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVL 1726
            V         E   + SP IPLE+LR KAL ML EAV+  G H RDPVGGSVEFQFVPVL
Sbjct: 1783 VAALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVL 1842

Query: 1727 KLIGTLLVMGVFDDDDVRQILLLIDPSVF-------GEHSAGTEE------------GAE 1767
            KL+ TLLVMG+F D+DV+QIL +I+P VF        E   G EE              E
Sbjct: 1843 KLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQE 1902

Query: 1768 KEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIV 1827
            KE+  + EE+A E  ++ G E   +GLLQ +LPESVKLQMC LL Y CD ELQHRVE++ 
Sbjct: 1903 KEDEEKEEEEAAEGEKEEGLE---EGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLA 1959

Query: 1828 AFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTKEFRSPPQEQINMLLNFQLG---E 1884
            AF + YV KLQANQ+ RY  L++A +M+AA TAR+T+EFRSPPQEQINMLL F+ G   E
Sbjct: 1960 AFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEE 2019

Query: 1885 NCPCPEEIREELYDFHEDLLLHCGVPLE-EEEEEEEDTSWTGKLCALVYKI----KGPPK 1939
            +CP PEEIR++L DFH+DLL HCG+ L+ EEEE EE+T+   +L +L+ K+    K   K
Sbjct: 2020 DCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEK 2079

Query: 1940 PEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVRMMFNLLRRQYDSIGELLQA 1999
            PE+E+  EE +  P +L+EL+S  ++ WAQED +Q  ELVR MF+LL RQYD +GELL+A
Sbjct: 2080 PEEERSAEESK--PRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRA 2137

Query: 2000 LRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNL 2059
            L + YTIS +SV DT++LL  LGQIRSLL V+MG +EE LMI  +G+IMNNKVFYQHPNL
Sbjct: 2138 LPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNL 2197

Query: 2060 MRVLGMHETVMEVMVNVLGT-EKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYL 2118
            MR LGMHETVMEVMVNVLG  E  +I FPKMV SCCRFLCYFCRISRQNQ++MF+HLSYL
Sbjct: 2198 MRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYL 2257

Query: 2119 LENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLEKVVTYLAGCGLQSCPMLL 2178
            LENS +GL    M+GSTPLDVAA+SV+DNNELAL+L+E DLEKVV+YLAGCGLQSCPML+
Sbjct: 2258 LENSGIGLG---MQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLV 2314

Query: 2179 AKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGN 2238
            AKGYPD+GWNP  GERYL FLRFAVFVN ESVEENA+VVV+LLIR+PECFGPALRGEGG+
Sbjct: 2315 AKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGS 2374

Query: 2239 GLLAAMQGAIKISENPALDLPS-QGYKREVSTGDDEEEEEIVHMGNAIMSFYSALIDLLG 2297
            GLLAA++ AI+ISE+PA D P  +  +R    G++  EE  VH+G+AIMSFY+ALIDLLG
Sbjct: 2375 GLLAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLG 2434

Query: 2298 RCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANF 2357
            RCAPEMHLIQ GKGEA+RIR+ILRSLVP EDLVGIIS+PL++P+L KDG++ +P M+A+F
Sbjct: 2435 RCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASF 2494

Query: 2358 CPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYI 2417
             PDHKA MVLFLDRVYGI++Q FLLH+L+VGFLPD+RA+ASLDT + STTE ALALNRY+
Sbjct: 2495 VPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYL 2554

Query: 2418 CSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHL 2477
            C AVLPL+T+CAPLFAGTEH   ++DS L T+YRLS+GRSLTKAQRD IE+CL+++C ++
Sbjct: 2555 CLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYI 2614

Query: 2478 RPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHL 2537
            RPSMLQ LLRRLVFDVP LNE+ KMPLKLLTNHYE+CWKYYCLP+GW ++G+  EEELHL
Sbjct: 2615 RPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHL 2674

Query: 2538 TEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQISVDADGN 2597
            T KLFWGIFDSL+HKKYDP+L+RMA+PCL AIAGALPPDY+D   ++  EK+ +VDA+GN
Sbjct: 2675 TRKLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGN 2734

Query: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657
            FDP+P+ T+N  +PEKL+  + K+AE++H+KWA DK Q+ W YG ++DE +KTHP++RP+
Sbjct: 2735 FDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPY 2794

Query: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQANQG---- 2713
            KT +EK+KEIYRWP +ESLK M+A  WT+E+ +EGE   ++ E +K R +SQ+ Q     
Sbjct: 2795 KTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEE--EKTEKKKTRKISQSAQTYDPR 2852

Query: 2714 NSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLT 2773
              Y+P P DLS V LSRELQ M E +AENYHN W +KKK ELE+KGGG+HPLLVPYDTLT
Sbjct: 2853 EGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLT 2912

Query: 2774 AKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQE 2833
            AKEK +DREKAQ+L KFLQ+NG  V+RG+KDMELD+SS+EKRFA+ FL+++L+++D +QE
Sbjct: 2913 AKEKARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQE 2972

Query: 2834 FIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLSSPLKPLSSSGYAS 2893
            FIAHLEA+VSSG+ EKSP +QEIKFFAK+LLPL++QYFT+HCLYFLS+P K L S G+AS
Sbjct: 2973 FIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHAS 3032

Query: 2894 HKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGL 2953
            +KEKEM+  LFCKLAALVRHR+SLFG+D+  +V+CLHILA++LD RTVMKSG E+VKAGL
Sbjct: 3033 NKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGL 3092

Query: 2954 RAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVTQHQF 3013
            R+FFE+A+ED+EK  ENL+LGK + +RTQ+KGV QN+ YTTVALLP+LT++F+H+ QHQF
Sbjct: 3093 RSFFESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQF 3152

Query: 3014 GMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNR 3073
            G D++L DVQ+SCY  LCS+YSLGT KN YVE+ RPALGECLA LAAA+PVAFLEP LN 
Sbjct: 3153 GDDVILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNE 3212

Query: 3074 YNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEV 3133
            YN  SV+ TK+PRER+ILG+P++VE+MCPDIP LE LM +I  LAESGARYTEMPHVIE+
Sbjct: 3213 YNACSVYTTKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEI 3272

Query: 3134 ILPMLCNYLSYWWERGPEN----LPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEA 3189
             LPMLC+YL  WWERGPE     LP    P CT VTS+HL+ +LGNIL+II NNLGIDEA
Sbjct: 3273 TLPMLCSYLPRWWERGPEAPPSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEA 3332

Query: 3190 SWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADGKGDTQEAEL 3249
            SWMKR+AV+AQPI+S+ARP+LL+SHFIPT+ +L+K+A K V EEEQL+ + K + QE EL
Sbjct: 3333 SWMKRLAVFAQPIVSRARPELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGEL 3392

Query: 3250 LILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFK 3309
            L+ DEF+VLCRDLYA YP+LIRYVDNNR+ WL  P+  +++LFRMV E+FI W KSHNFK
Sbjct: 3393 LVRDEFSVLCRDLYALYPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFK 3452

Query: 3310 REEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVA 3369
            REEQNFV+QNEINN++FLT D+KSKM+KA  ++SGG DQER K KRRGD YS+QTSLIVA
Sbjct: 3453 REEQNFVVQNEINNMSFLTADNKSKMAKAGDIQSGGSDQERTKKKRRGDRYSVQTSLIVA 3512

Query: 3370 ALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKSD-DPAVKWQ 3428
             LKKMLPIGLNMC P DQ+LI+LAK+RY+ +DTDEEVRE L NNLHLQ K +  P+++WQ
Sbjct: 3513 TLKKMLPIGLNMCAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQ 3572

Query: 3429 LNLYKDVL-KSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAV 3487
            + LY+ V  + E+  +PEK V RVQ +SA +++L+Q E P +SKKAVWHKLLSKQR+RAV
Sbjct: 3573 MALYRGVPGREEDADDPEKIVRRVQEVSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAV 3632

Query: 3488 VACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEETE 3547
            VACFRM PLYNLP HR+ N+FL  Y+  WI TE++SFE++++ DL+K+ + EEEEEE  E
Sbjct: 3633 VACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEE 3692

Query: 3548 KQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSC---QSGEDEEEDEDKEKTF 3604
            K+PDPLHQ++L+FSR ALTE+SKL++D LY +Y+ +MAKSC   + GE+ E +E+ E +F
Sbjct: 3693 KKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEEVEVSF 3752

Query: 3605 EEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQ 3664
            EEK+MEKQ+ LYQQARLH RGAAEMVLQMISA KGE   MV  TLKLGI+ILNGGNA VQ
Sbjct: 3753 EEKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQ 3812

Query: 3665 QKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEK 3724
            QKMLDYLK+KK+ GFFQS+  LMQ+CSVLDLNAFERQNKAEGLGMV E+GT+I R+ GEK
Sbjct: 3813 QKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEK 3872

Query: 3725 VLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDF 3784
            V+ +DEFT+DLFRFLQLLCEGHN+DFQN+LRTQ GNTTT+N+II TVDYLLRLQESISDF
Sbjct: 3873 VMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDF 3932

Query: 3785 YWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFL 3844
            YWYYSGKD+I+E G+ NFSKA++V KQ+FNSLTEYIQGPC GNQQSLAHSRLWDAVVGFL
Sbjct: 3933 YWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFL 3992

Query: 3845 HVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESST 3904
            HVFA+M MKL+QDSSQIELLKELLDL +DMVVMLLSLLEGNVVNG I +QMVD LVESS+
Sbjct: 3993 HVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSS 4052

Query: 3905 NVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLS 3964
            NVEMILKFFDMFLKLKD+  S+ F++Y  D +G+ISKK+FQKAM+ QKQ++  EI FLLS
Sbjct: 4053 NVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLS 4112

Query: 3965 CAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNY 4024
            C+EADEN+M N  +F +RF EPA+DIGFNVAVLLTNLSEH+P+D RL   L+ AES+L Y
Sbjct: 4113 CSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLELAESILEY 4172

Query: 4025 FEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMEL 4084
            F PYLGRIEIMG +++IER+YFEISE++R QWE PQVKESKRQFIFDVVNEGGE EKMEL
Sbjct: 4173 FRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMEL 4232

Query: 4085 FVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLE--PASAF 4142
            FV+FCEDTIFEMQ+A+QISE +    PE +E++   +      G EE    LE   A+A 
Sbjct: 4233 FVSFCEDTIFEMQIAAQISEPEG--EPETDEDEGAGAAEAGAEGAEEGAAGLEGTAATAA 4290

Query: 4143 AMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLFTI 4202
            A A A V       L+  + ++LR++ R ++++TA+E    + +  W             
Sbjct: 4291 AGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTRAGAAGAGA 4350

Query: 4203 LGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGITT 4262
              G   +LW ++FGGGLVEGAK + VT++L  MPDPT   +H +       +    G + 
Sbjct: 4351 AAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDADGEGASE 4410

Query: 4263 ELVHFIKGEKGDTDIMSDL------FGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLE 4316
                  +G   + + + +         +     G  +     GLGD+ +     EPPT E
Sbjct: 4411 GAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTT-PAEPPTPE 4469

Query: 4317 STVQKKRK------AQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVT 4370
             +   KRK       +    +   E E ++E EKAD E+GEKE+  +   +         
Sbjct: 4470 GSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPE--------- 4520

Query: 4371 KKKKRRCGQKVEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLF 4430
              KK+       K E     F+  LE+ + K L+YL+RNFY LRFLALF+AFAINFILLF
Sbjct: 4521 PPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLF 4580

Query: 4431 YKVTEEPLEEE------TEDVANL-------WNSFNDEE----EEEAMVFFVLQESTGYM 4473
            YKV++ P  E+        DV+         W     EE    E+E MV++ L+ESTGYM
Sbjct: 4581 YKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYFLEESTGYM 4640

Query: 4474 APTLRALAIIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKG 4533
             P LR L+++HT+++ +C++GY CLKVPLV+FKREKE+ARKLEFDGLYITEQP +DD+KG
Sbjct: 4641 EPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKG 4700

Query: 4534 QWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAE 4593
            QWDRLV+NTPSFP+NYWDKFVKRKV++K+GD+YG ERIAELLG+D   L+ +   E K  
Sbjct: 4701 QWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEITAHNERKPN 4760

Query: 4594 -AASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMG 4652
                L++WL SID+KY IWK GV+FTDNSFLYL WY  MS+LGHYNNFFFAAHLLDIAMG
Sbjct: 4761 PPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMG 4820

Query: 4653 FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDM 4712
             KTLRTILSSVTHNGKQLV+TVGLLAVVVYLYTVVAFNFFRKFYNKSED+DEPDMKCDDM
Sbjct: 4821 VKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDM 4880

Query: 4713 MTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDA 4772
            MTCYLFHMYVGVRAGGGIGDEIEDPAGD YE+YR+VFDITFFFFVIVILLAIIQGLIIDA
Sbjct: 4881 MTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDA 4940

Query: 4773 FGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKD 4832
            FGELRDQQEQV+EDMETKCFICGIG+DYFDTTPHGFETHTL+EHNLANY+FFLMYLINKD
Sbjct: 4941 FGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKD 5000

Query: 4833 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL 4869
            ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL
Sbjct: 5001 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL 5037



 Score = 1896 bits (4911), Expect = 0.0
 Identities = 906/1308 (69%), Positives = 1084/1308 (82%), Gaps = 20/1308 (1%)

Query: 4    GGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDL 63
            G   GEDE+QFLRT+DEVVLQC AT+ KEQ K CLAAEG GNRLCFLEPTS A+ +PPDL
Sbjct: 2    GDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDL 61

Query: 64   CVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYLTCL 123
             +C FVLEQSLSVRALQEMLANT E G E ++QGGGHRTLLYGHA+LLRH+ S MYL+CL
Sbjct: 62   AICCFVLEQSLSVRALQEMLANTVEAGVE-SSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120

Query: 124  TTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLH 183
            TTSRS TDKLAFDVGL+E ATGEACWWT+HPASKQRSEGEKVR+GDD+ILVSVSSERYLH
Sbjct: 121  TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180

Query: 184  LSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGH-DECLTIPSTDQN 242
            LS ++G +QVDASFMQTLWN++P CS    EEG++ GGHV+RLFHGH DECLTI   D +
Sbjct: 181  LSTASGELQVDASFMQTLWNMNPICS--RCEEGFVTGGHVLRLFHGHMDECLTISPADSD 238

Query: 243  DSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQG 302
            D Q R ++YE G   T ARSLWR+EPLRISWSGS++RWGQ  R+RH+TTG YLALTEDQG
Sbjct: 239  D-QRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQG 297

Query: 303  LILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIASGL 362
            L++ D +K+ TK+T+F FR SKE   KLD + KRD+EGMG PEIKYG+S+CFVQH+ASGL
Sbjct: 298  LVVVDASKAHTKATSFCFRISKE---KLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGL 354

Query: 363  WVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFV 422
            W+TY A D K  RLG LK+K +LHQEGHMDD L+L RCQ+EESQAAR+I +T  L++QF+
Sbjct: 355  WLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFI 414

Query: 423  ------SGNNRTAAP---ITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQ 473
                  SG  R + P     LPIE V+ +LQDLI YF+PP E+++HE+KQ+KLRSL+NRQ
Sbjct: 415  KSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQ 474

Query: 474  NLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRN 533
            +LF+EEGML++VLNCIDRLNVY + AHFA  A EE+  +WKEI+NLLY+LLA+LIRGNR+
Sbjct: 475  SLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRS 534

Query: 534  NCAQFSNNLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGR 593
            NCA FS NLDWL+SKLDRLE+SSGILEVL+C+L ESPE LN+I E HIKSIISLLDKHGR
Sbjct: 535  NCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGR 594

Query: 594  NHKVLDILCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEG 653
            NHKVLD+LCSLC+CNGVAVR+NQ+LI +NLLP R LLLQT LIN VTSIRPNIF+G AEG
Sbjct: 595  NHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEG 654

Query: 654  SAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYG 713
            + QY KWYFE+++D+V PFLTA+ THLRVGWA + GY PYPG GEGWGGNGVGDDLYSYG
Sbjct: 655  TTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYG 714

Query: 714  FDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDG 773
            FDGLHLW+G + R V S  QHLL  +DV+SCCLDL VPSISFRING PVQG+FE+FN DG
Sbjct: 715  FDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDG 774

Query: 774  LFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADG 833
            LFFPV+SFSAGVKVRFL+GGRHGEFKFLPP GYAPC+EA+LP+E++ LEP+KEY+R+   
Sbjct: 775  LFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPR 834

Query: 834  IRDLLGTTQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGK 893
               L+G ++ LS   F+PCPVDT Q++LPPHLE+IR++LAENIHELW + +IE GWT+G 
Sbjct: 835  GPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGP 894

Query: 894  IRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKL 953
            +RDDNKR HPCLV+F  LPE E+NYNLQMS ETLKTLLALGCH+   +  AE++LKK KL
Sbjct: 895  VRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKL 954

Query: 954  PKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKN 1013
            PK YMMSNGYKPAPLDLS V+L P Q  LVD+LAEN HNVWA+DR+ QGW+Y   QD+  
Sbjct: 955  PKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPA 1014

Query: 1014 KRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVS-IDKIR 1072
            +RNPRLVPY LLDE TK+SNRDSL +AVRT +GYGYNIEP DQE   S VE  S  D++R
Sbjct: 1015 RRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQE--PSQVENQSRCDRVR 1072

Query: 1073 FFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWH 1132
             FR E+SY V+SG+WYFEFE VT G+MRVGWARP  RPDVELGAD+ A+VF G+RGQRWH
Sbjct: 1073 IFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWH 1132

Query: 1133 QGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICC 1192
             GS  FGR WQPGDVVGCMI+L + ++IFTLNGE+L+++ GSE AF + EI +GF+P+C 
Sbjct: 1133 LGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCS 1192

Query: 1193 LGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHP 1252
            LG  Q+G +NLG D S+ +F+ +CGLQEGFEPFA+NM R V  WFSK LP F  VP +HP
Sbjct: 1193 LGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHP 1252

Query: 1253 HIEVMRIDGTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSF 1300
            H EV R+DGT+D+PPCL++TH+T+G+QNS  +M++ RLS+PV+ H  F
Sbjct: 1253 HYEVSRVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHF 1300



 Score =  109 bits (273), Expect = 6e-23
 Identities = 71/232 (30%), Positives = 111/232 (47%), Gaps = 20/232 (8%)

Query: 845  SQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPC 904
            ++ +F P PV+T  VI+P  L+   ++ AE  HE W  +KI+  W++G+  D+  + HP 
Sbjct: 2731 AEGNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPM 2790

Query: 905  LVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPK------NYM 958
            L  +    E +K        E+LK ++A    I       EE  +K K  K       Y 
Sbjct: 2791 LRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYD 2850

Query: 959  MSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNK---R 1015
               GY P P DLS V L    + + ++LAEN HN W + +         +Q+L+ K    
Sbjct: 2851 PREGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKK---------KQELEAKGGGT 2901

Query: 1016 NPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEP--SDQELADSAVEK 1065
            +P LVPY  L  + K  +R+  +E ++     GY +     D EL  S++EK
Sbjct: 2902 HPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEK 2953



 Score =  103 bits (258), Expect = 3e-21
 Identities = 66/193 (34%), Positives = 101/193 (52%), Gaps = 12/193 (6%)

Query: 2597 NFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRP 2656
            +F P P++T+   LP  LE I  K AE+ H+ WA  + + GW YG   D+N + HP +  
Sbjct: 849  DFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVD 908

Query: 2657 FKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQREN-EKLRSVSQANQGNS 2715
            F +L E E+      + E+LKT+LA+G  V     G A  +  +N +K +        N 
Sbjct: 909  FHSLPEPERNYNLQMSGETLKTLLALGCHV-----GMADEKAEDNLKKTKLPKTYMMSNG 963

Query: 2716 YSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLE------LESKGGGSHPLLVPY 2769
            Y PAPLDLS+V L+     +V+ +AEN HN+WA+ +  +      ++      +P LVPY
Sbjct: 964  YKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPY 1023

Query: 2770 DTLTAKEKFKDRE 2782
              L    K  +R+
Sbjct: 1024 RLLDEATKRSNRD 1036



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 25/102 (24%), Positives = 50/102 (49%)

Query: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657
            + P P++  +  L      +V + AE+ H+ WA D+   GW Y    D   + +P + P+
Sbjct: 964  YKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPY 1023

Query: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQR 2699
            + L E  K   R    ++++T+L  G+ +E   +  + V+ +
Sbjct: 1024 RLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQ 1065


>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
            sapiens]
          Length = 5033

 Score = 4762 bits (12353), Expect = 0.0
 Identities = 2378/3637 (65%), Positives = 2891/3637 (79%), Gaps = 114/3637 (3%)

Query: 1319 EILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRV 1378
            EI+ +TTT  YY++R+FAGQ+PSCVW GWVTPDYH +   FDL+K   VTVT+GDE+G V
Sbjct: 1424 EIILNTTTY-YYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNV 1482

Query: 1379 HESVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVE 1438
            H S+K SNCYMVWGGD V+  Q+   S+ DL IGCLVDLA G+++F+ANGKE  T +QVE
Sbjct: 1483 HSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVE 1542

Query: 1439 PNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPV 1498
            PNTK+FPAVF+ PT  ++ QFELGK KN MPLSAA+F+SE KNP PQCPPRL++Q + PV
Sbjct: 1543 PNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPV 1602

Query: 1499 LWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFH 1558
             WSRMPN FL+VET R  ER GW VQC EPL MMALHIPEENRC+DILEL E+ DL RFH
Sbjct: 1603 SWSRMPNHFLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFH 1662

Query: 1559 YHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASA 1618
             HTLRLY AVCALGN+RVA+ALCSHVD +QL +A+++ +LPG LR+G+YDLLISIHL SA
Sbjct: 1663 SHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESA 1722

Query: 1619 KERKLMMKNEYIIPITSTTRNIRLFP------DESKRHGLPGVGLRTCLKPGFRFSTPCF 1672
               +  M +EYI+P+T  TR I LFP      +   RHGLPGVG+ T L+P   FS PCF
Sbjct: 1723 CRSRRSMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCF 1782

Query: 1673 VVT------GEDHQKQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVL 1726
            V         E   + SP IPLE+LR KAL ML EAV+  G H RDPVGGSVEFQFVPVL
Sbjct: 1783 VAALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVL 1842

Query: 1727 KLIGTLLVMGVFDDDDVRQILLLIDPSVF-------GEHSAGTEE------------GAE 1767
            KL+ TLLVMG+F D+DV+QIL +I+P VF        E   G EE              E
Sbjct: 1843 KLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQE 1902

Query: 1768 KEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIV 1827
            KE+  + EE+A E  ++ G E   +GLLQ +LPESVKLQMC LL Y CD ELQHRVE++ 
Sbjct: 1903 KEDEEKEEEEAAEGEKEEGLE---EGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLA 1959

Query: 1828 AFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTKEFRSPPQEQINMLLNFQLG---E 1884
            AF + YV KLQANQ+ RY  L++A +M+AA TAR+T+EFRSPPQEQINMLL F+ G   E
Sbjct: 1960 AFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEE 2019

Query: 1885 NCPCPEEIREELYDFHEDLLLHCGVPLE-EEEEEEEDTSWTGKLCALVYKI----KGPPK 1939
            +CP PEEIR++L DFH+DLL HCG+ L+ EEEE EE+T+   +L +L+ K+    K   K
Sbjct: 2020 DCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEK 2079

Query: 1940 PEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVRMMFNLLRRQYDSIGELLQA 1999
            PE+E+  EE +  P +L+EL+S  ++ WAQED +Q  ELVR MF+LL RQYD +GELL+A
Sbjct: 2080 PEEERSAEESK--PRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRA 2137

Query: 2000 LRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNL 2059
            L + YTIS +SV DT++LL  LGQIRSLL V+MG +EE LMI  +G+IMNNKVFYQHPNL
Sbjct: 2138 LPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNL 2197

Query: 2060 MRVLGMHETVMEVMVNVLGT-EKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYL 2118
            MR LGMHETVMEVMVNVLG  E  +I FPKMV SCCRFLCYFCRISRQNQ++MF+HLSYL
Sbjct: 2198 MRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYL 2257

Query: 2119 LENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLEKVVTYLAGCGLQSCPMLL 2178
            LENS +GL    M+GSTPLDVAA+SV+DNNELAL+L+E DLEKVV+YLAGCGLQSCPML+
Sbjct: 2258 LENSGIGLG---MQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLV 2314

Query: 2179 AKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGN 2238
            AKGYPD+GWNP  GERYL FLRFAVFVN ESVEENA+VVV+LLIR+PECFGPALRGEGG+
Sbjct: 2315 AKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGS 2374

Query: 2239 GLLAAMQGAIKISENPALDLPS-QGYKREVSTGDDEEEEEIVHMGNAIMSFYSALIDLLG 2297
            GLLAA++ AI+ISE+PA D P  +  +R    G++  EE  VH+G+AIMSFY+ALIDLLG
Sbjct: 2375 GLLAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLG 2434

Query: 2298 RCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANF 2357
            RCAPEMHLIQ GKGEA+RIR+ILRSLVP EDLVGIIS+PL++P+L KDG++ +P M+A+F
Sbjct: 2435 RCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASF 2494

Query: 2358 CPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYI 2417
             PDHKA MVLFLDRVYGI++Q FLLH+L+VGFLPD+RA+ASLDT + STTE ALALNRY+
Sbjct: 2495 VPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYL 2554

Query: 2418 CSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHL 2477
            C AVLPL+T+CAPLFAGTEH   ++DS L T+YRLS+GRSLTKAQRD IE+CL+++C ++
Sbjct: 2555 CLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYI 2614

Query: 2478 RPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHL 2537
            RPSMLQ LLRRLVFDVP LNE+ KMPLKLLTNHYE+CWKYYCLP+GW ++G+  EEELHL
Sbjct: 2615 RPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHL 2674

Query: 2538 TEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQISVDADGN 2597
            T KLFWGIFDSL+HKKYDP+L+RMA+PCL AIAGALPPDY+D   ++  EK+ +VDA+GN
Sbjct: 2675 TRKLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGN 2734

Query: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657
            FDP+P+ T+N  +PEKL+  + K+AE++H+KWA DK Q+ W YG ++DE +KTHP++RP+
Sbjct: 2735 FDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPY 2794

Query: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQANQG---- 2713
            KT +EK+KEIYRWP +ESLK M+A  WT+E+ +EGE   ++ E +K R +SQ+ Q     
Sbjct: 2795 KTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEE--EKTEKKKTRKISQSAQTYDPR 2852

Query: 2714 NSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLT 2773
              Y+P P DLS V LSRELQ M E +AENYHN W +KKK ELE+KGGG+HPLLVPYDTLT
Sbjct: 2853 EGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLT 2912

Query: 2774 AKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQE 2833
            AKEK +DREKAQ+L KFLQ+NG  V+RG+KDMELD+SS+EKRFA+ FL+++L+++D +QE
Sbjct: 2913 AKEKARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQE 2972

Query: 2834 FIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLSSPLKPLSSSGYAS 2893
            FIAHLEA+VSSG+ EKSP +QEIKFFAK+LLPL++QYFT+HCLYFLS+P K L S G+AS
Sbjct: 2973 FIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHAS 3032

Query: 2894 HKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGL 2953
            +KEKEM+  LFCKLAALVRHR+SLFG+D+  +V+CLHILA++LD RTVMKSG E+VKAGL
Sbjct: 3033 NKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGL 3092

Query: 2954 RAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVTQHQF 3013
            R+FFE+A+ED+EK  ENL+LGK + +RTQ+KGV QN+ YTTVALLP+LT++F+H+ QHQF
Sbjct: 3093 RSFFESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQF 3152

Query: 3014 GMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNR 3073
            G D++L DVQ+SCY  LCS+YSLGT KN YVE+ RPALGECLA LAAA+PVAFLEP LN 
Sbjct: 3153 GDDVILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNE 3212

Query: 3074 YNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEV 3133
            YN  SV+ TK+PRER+ILG+P++VE+MCPDIP LE LM +I  LAESGARYTEMPHVIE+
Sbjct: 3213 YNACSVYTTKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEI 3272

Query: 3134 ILPMLCNYLSYWWERGPEN----LPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEA 3189
             LPMLC+YL  WWERGPE     LP    P CT VTS+HL+ +LGNIL+II NNLGIDEA
Sbjct: 3273 TLPMLCSYLPRWWERGPEAPPSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEA 3332

Query: 3190 SWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADGKGDTQEAEL 3249
            SWMKR+AV+AQPI+S+ARP+LL+SHFIPT+ +L+K+A K V EEEQL+ + K + QE EL
Sbjct: 3333 SWMKRLAVFAQPIVSRARPELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGEL 3392

Query: 3250 LILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFK 3309
            L+ DEF+VLCRDLYA YP+LIRYVDNNR+ WL  P+  +++LFRMV E+FI W KSHNFK
Sbjct: 3393 LVRDEFSVLCRDLYALYPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFK 3452

Query: 3310 REEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVA 3369
            REEQNFV+QNEINN++FLT D+KSKM+K     SGG DQER K KRRGD YS+QTSLIVA
Sbjct: 3453 REEQNFVVQNEINNMSFLTADNKSKMAK-----SGGSDQERTKKKRRGDRYSVQTSLIVA 3507

Query: 3370 ALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKSD-DPAVKWQ 3428
             LKKMLPIGLNMC P DQ+LI+LAK+RY+ +DTDEEVRE L NNLHLQ K +  P+++WQ
Sbjct: 3508 TLKKMLPIGLNMCAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQ 3567

Query: 3429 LNLYKDVL-KSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAV 3487
            + LY+ V  + E+  +PEK V RVQ +SA +++L+Q E P +SKKAVWHKLLSKQR+RAV
Sbjct: 3568 MALYRGVPGREEDADDPEKIVRRVQEVSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAV 3627

Query: 3488 VACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEETE 3547
            VACFRM PLYNLP HR+ N+FL  Y+  WI TE++SFE++++ DL+K+ + EEEEEE  E
Sbjct: 3628 VACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEE 3687

Query: 3548 KQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSC---QSGEDEEEDEDKEKTF 3604
            K+PDPLHQ++L+FSR ALTE+SKL++D LY +Y+ +MAKSC   + GE+ E +E+ E +F
Sbjct: 3688 KKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEEVEVSF 3747

Query: 3605 EEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQ 3664
            EEK+MEKQ+ LYQQARLH RGAAEMVLQMISA KGE   MV  TLKLGI+ILNGGNA VQ
Sbjct: 3748 EEKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQ 3807

Query: 3665 QKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEK 3724
            QKMLDYLK+KK+ GFFQS+  LMQ+CSVLDLNAFERQNKAEGLGMV E+GT+I R+ GEK
Sbjct: 3808 QKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEK 3867

Query: 3725 VLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDF 3784
            V+ +DEFT+DLFRFLQLLCEGHN+DFQN+LRTQ GNTTT+N+II TVDYLLRLQESISDF
Sbjct: 3868 VMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDF 3927

Query: 3785 YWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFL 3844
            YWYYSGKD+I+E G+ NFSKA++V KQ+FNSLTEYIQGPC GNQQSLAHSRLWDAVVGFL
Sbjct: 3928 YWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFL 3987

Query: 3845 HVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESST 3904
            HVFA+M MKL+QDSSQIELLKELLDL +DMVVMLLSLLEGNVVNG I +QMVD LVESS+
Sbjct: 3988 HVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSS 4047

Query: 3905 NVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLS 3964
            NVEMILKFFDMFLKLKD+  S+ F++Y  D +G+ISKK+FQKAM+ QKQ++  EI FLLS
Sbjct: 4048 NVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLS 4107

Query: 3965 CAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNY 4024
            C+EADEN+M N  +F +RF EPA+DIGFNVAVLLTNLSEH+P+D RL   L+ AES+L Y
Sbjct: 4108 CSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLELAESILEY 4167

Query: 4025 FEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMEL 4084
            F PYLGRIEIMG +++IER+YFEISE++R QWE PQVKESKRQFIFDVVNEGGE EKMEL
Sbjct: 4168 FRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMEL 4227

Query: 4085 FVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLE--PASAF 4142
            FV+FCEDTIFEMQ+A+QISE +    PE +E++   +      G EE    LE   A+A 
Sbjct: 4228 FVSFCEDTIFEMQIAAQISEPEG--EPETDEDEGAGAAEAGAEGAEEGAAGLEGTAATAA 4285

Query: 4143 AMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLFTI 4202
            A A A V       L+  + ++LR++ R ++++TA+E    + +  W             
Sbjct: 4286 AGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTRAGAAGAGA 4345

Query: 4203 LGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGITT 4262
              G   +LW ++FGGGLVEGAK + VT++L  MPDPT   +H +       +    G + 
Sbjct: 4346 AAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDADGEGASE 4405

Query: 4263 ELVHFIKGEKGDTDIMSDL------FGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLE 4316
                  +G   + + + +         +     G  +     GLGD+ +     EPPT E
Sbjct: 4406 GAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTT-PAEPPTPE 4464

Query: 4317 STVQKKRK------AQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVT 4370
             +   KRK       +    +   E E ++E EKAD E+GEKE+  +   +         
Sbjct: 4465 GSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPE--------- 4515

Query: 4371 KKKKRRCGQKVEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLF 4430
              KK+       K E     F+  LE+ + K L+YL+RNFY LRFLALF+AFAINFILLF
Sbjct: 4516 PPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLF 4575

Query: 4431 YKVTEEPLEEE------TEDVANL-------WNSFNDEE----EEEAMVFFVLQESTGYM 4473
            YKV++ P  E+        DV+         W     EE    E+E MV++ L+ESTGYM
Sbjct: 4576 YKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYFLEESTGYM 4635

Query: 4474 APTLRALAIIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKG 4533
             P LR L+++HT+++ +C++GY CLKVPLV+FKREKE+ARKLEFDGLYITEQP +DD+KG
Sbjct: 4636 EPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKG 4695

Query: 4534 QWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAE 4593
            QWDRLV+NTPSFP+NYWDKFVKRKV++K+GD+YG ERIAELLG+D   L+ +   E K  
Sbjct: 4696 QWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEITAHNERKPN 4755

Query: 4594 -AASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMG 4652
                L++WL SID+KY IWK GV+FTDNSFLYL WY  MS+LGHYNNFFFAAHLLDIAMG
Sbjct: 4756 PPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMG 4815

Query: 4653 FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDM 4712
             KTLRTILSSVTHNGKQLV+TVGLLAVVVYLYTVVAFNFFRKFYNKSED+DEPDMKCDDM
Sbjct: 4816 VKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDM 4875

Query: 4713 MTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDA 4772
            MTCYLFHMYVGVRAGGGIGDEIEDPAGD YE+YR+VFDITFFFFVIVILLAIIQGLIIDA
Sbjct: 4876 MTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDA 4935

Query: 4773 FGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKD 4832
            FGELRDQQEQV+EDMETKCFICGIG+DYFDTTPHGFETHTL+EHNLANY+FFLMYLINKD
Sbjct: 4936 FGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKD 4995

Query: 4833 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL 4869
            ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL
Sbjct: 4996 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL 5032



 Score = 1896 bits (4911), Expect = 0.0
 Identities = 906/1308 (69%), Positives = 1084/1308 (82%), Gaps = 20/1308 (1%)

Query: 4    GGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDL 63
            G   GEDE+QFLRT+DEVVLQC AT+ KEQ K CLAAEG GNRLCFLEPTS A+ +PPDL
Sbjct: 2    GDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDL 61

Query: 64   CVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYLTCL 123
             +C FVLEQSLSVRALQEMLANT E G E ++QGGGHRTLLYGHA+LLRH+ S MYL+CL
Sbjct: 62   AICCFVLEQSLSVRALQEMLANTVEAGVE-SSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120

Query: 124  TTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLH 183
            TTSRS TDKLAFDVGL+E ATGEACWWT+HPASKQRSEGEKVR+GDD+ILVSVSSERYLH
Sbjct: 121  TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180

Query: 184  LSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGH-DECLTIPSTDQN 242
            LS ++G +QVDASFMQTLWN++P CS    EEG++ GGHV+RLFHGH DECLTI   D +
Sbjct: 181  LSTASGELQVDASFMQTLWNMNPICS--RCEEGFVTGGHVLRLFHGHMDECLTISPADSD 238

Query: 243  DSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQG 302
            D Q R ++YE G   T ARSLWR+EPLRISWSGS++RWGQ  R+RH+TTG YLALTEDQG
Sbjct: 239  D-QRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQG 297

Query: 303  LILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIASGL 362
            L++ D +K+ TK+T+F FR SKE   KLD + KRD+EGMG PEIKYG+S+CFVQH+ASGL
Sbjct: 298  LVVVDASKAHTKATSFCFRISKE---KLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGL 354

Query: 363  WVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFV 422
            W+TY A D K  RLG LK+K +LHQEGHMDD L+L RCQ+EESQAAR+I +T  L++QF+
Sbjct: 355  WLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFI 414

Query: 423  ------SGNNRTAAP---ITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQ 473
                  SG  R + P     LPIE V+ +LQDLI YF+PP E+++HE+KQ+KLRSL+NRQ
Sbjct: 415  KSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQ 474

Query: 474  NLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRN 533
            +LF+EEGML++VLNCIDRLNVY + AHFA  A EE+  +WKEI+NLLY+LLA+LIRGNR+
Sbjct: 475  SLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRS 534

Query: 534  NCAQFSNNLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGR 593
            NCA FS NLDWL+SKLDRLE+SSGILEVL+C+L ESPE LN+I E HIKSIISLLDKHGR
Sbjct: 535  NCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGR 594

Query: 594  NHKVLDILCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEG 653
            NHKVLD+LCSLC+CNGVAVR+NQ+LI +NLLP R LLLQT LIN VTSIRPNIF+G AEG
Sbjct: 595  NHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEG 654

Query: 654  SAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYG 713
            + QY KWYFE+++D+V PFLTA+ THLRVGWA + GY PYPG GEGWGGNGVGDDLYSYG
Sbjct: 655  TTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYG 714

Query: 714  FDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDG 773
            FDGLHLW+G + R V S  QHLL  +DV+SCCLDL VPSISFRING PVQG+FE+FN DG
Sbjct: 715  FDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDG 774

Query: 774  LFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADG 833
            LFFPV+SFSAGVKVRFL+GGRHGEFKFLPP GYAPC+EA+LP+E++ LEP+KEY+R+   
Sbjct: 775  LFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPR 834

Query: 834  IRDLLGTTQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGK 893
               L+G ++ LS   F+PCPVDT Q++LPPHLE+IR++LAENIHELW + +IE GWT+G 
Sbjct: 835  GPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGP 894

Query: 894  IRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKL 953
            +RDDNKR HPCLV+F  LPE E+NYNLQMS ETLKTLLALGCH+   +  AE++LKK KL
Sbjct: 895  VRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKL 954

Query: 954  PKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKN 1013
            PK YMMSNGYKPAPLDLS V+L P Q  LVD+LAEN HNVWA+DR+ QGW+Y   QD+  
Sbjct: 955  PKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPA 1014

Query: 1014 KRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVS-IDKIR 1072
            +RNPRLVPY LLDE TK+SNRDSL +AVRT +GYGYNIEP DQE   S VE  S  D++R
Sbjct: 1015 RRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQE--PSQVENQSRCDRVR 1072

Query: 1073 FFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWH 1132
             FR E+SY V+SG+WYFEFE VT G+MRVGWARP  RPDVELGAD+ A+VF G+RGQRWH
Sbjct: 1073 IFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWH 1132

Query: 1133 QGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICC 1192
             GS  FGR WQPGDVVGCMI+L + ++IFTLNGE+L+++ GSE AF + EI +GF+P+C 
Sbjct: 1133 LGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCS 1192

Query: 1193 LGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHP 1252
            LG  Q+G +NLG D S+ +F+ +CGLQEGFEPFA+NM R V  WFSK LP F  VP +HP
Sbjct: 1193 LGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHP 1252

Query: 1253 HIEVMRIDGTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSF 1300
            H EV R+DGT+D+PPCL++TH+T+G+QNS  +M++ RLS+PV+ H  F
Sbjct: 1253 HYEVSRVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHF 1300



 Score =  109 bits (273), Expect = 6e-23
 Identities = 71/232 (30%), Positives = 111/232 (47%), Gaps = 20/232 (8%)

Query: 845  SQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPC 904
            ++ +F P PV+T  VI+P  L+   ++ AE  HE W  +KI+  W++G+  D+  + HP 
Sbjct: 2731 AEGNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPM 2790

Query: 905  LVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPK------NYM 958
            L  +    E +K        E+LK ++A    I       EE  +K K  K       Y 
Sbjct: 2791 LRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYD 2850

Query: 959  MSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNK---R 1015
               GY P P DLS V L    + + ++LAEN HN W + +         +Q+L+ K    
Sbjct: 2851 PREGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKK---------KQELEAKGGGT 2901

Query: 1016 NPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEP--SDQELADSAVEK 1065
            +P LVPY  L  + K  +R+  +E ++     GY +     D EL  S++EK
Sbjct: 2902 HPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEK 2953



 Score =  103 bits (258), Expect = 3e-21
 Identities = 66/193 (34%), Positives = 101/193 (52%), Gaps = 12/193 (6%)

Query: 2597 NFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRP 2656
            +F P P++T+   LP  LE I  K AE+ H+ WA  + + GW YG   D+N + HP +  
Sbjct: 849  DFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVD 908

Query: 2657 FKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQREN-EKLRSVSQANQGNS 2715
            F +L E E+      + E+LKT+LA+G  V     G A  +  +N +K +        N 
Sbjct: 909  FHSLPEPERNYNLQMSGETLKTLLALGCHV-----GMADEKAEDNLKKTKLPKTYMMSNG 963

Query: 2716 YSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLE------LESKGGGSHPLLVPY 2769
            Y PAPLDLS+V L+     +V+ +AEN HN+WA+ +  +      ++      +P LVPY
Sbjct: 964  YKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPY 1023

Query: 2770 DTLTAKEKFKDRE 2782
              L    K  +R+
Sbjct: 1024 RLLDEATKRSNRD 1036



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 25/102 (24%), Positives = 50/102 (49%)

Query: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657
            + P P++  +  L      +V + AE+ H+ WA D+   GW Y    D   + +P + P+
Sbjct: 964  YKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPY 1023

Query: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQR 2699
            + L E  K   R    ++++T+L  G+ +E   +  + V+ +
Sbjct: 1024 RLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQ 1065


>gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo
            sapiens]
          Length = 2701

 Score =  167 bits (423), Expect = 2e-40
 Identities = 93/288 (32%), Positives = 151/288 (52%), Gaps = 47/288 (16%)

Query: 4616 VFTDNSFLYLAWYTTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTV 4674
            V  D +FLY   Y  + +LG + + FF++  L D+    +TL  ++ SVT NG+ ++LT 
Sbjct: 2340 VILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTA 2399

Query: 4675 GLLAVVVYLYTVVAFNFFRKFYNKSED--------------------------------- 4701
             L  ++VYL++++ F F +  +    D                                 
Sbjct: 2400 VLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSP 2459

Query: 4702 ------------DDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD-PYEMYRIV 4748
                        +D  +  CD ++ C +  +  G+R GGG+GD +  P+ D P    R+V
Sbjct: 2460 TIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVV 2519

Query: 4749 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGF 4808
            +D+ F+F VI+I+L +I G+IID F +LR ++++  E ++T CFICG+  D FD     F
Sbjct: 2520 YDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSF 2579

Query: 4809 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 4856
            E H   EHN+ +YL+F++ +  KD TE+TG ESYV +M  E+  D+FP
Sbjct: 2580 EEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFP 2627



 Score =  119 bits (298), Expect = 7e-26
 Identities = 140/581 (24%), Positives = 245/581 (42%), Gaps = 73/581 (12%)

Query: 105 YGHAVLLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEK 164
           Y + + L H  S  YLT      +  +K A  V L + A  E  W+ IHP  K RSEG+ 
Sbjct: 117 YSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSL-DAAGNEGSWFYIHPFWKLRSEGDN 175

Query: 165 VRIGDDLILVSVSSERYLHLS-----VSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLL 219
           + +GD ++L+ V++ + LH S      + G  +V+A    T W +      SS  E  L 
Sbjct: 176 IVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLK 235

Query: 220 GGHVVRLFHGHDECLTIPSTDQNDSQH---RRIFYEAGGAGTRARSLWRVEPLRIS-WSG 275
           GG VVRLFH   E   +   +    QH   R    ++  + T +++LW +E +      G
Sbjct: 236 GGDVVRLFHAEQEKF-LTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRG 294

Query: 276 SNIRWGQAFRLRHLTTGHYLAL--------TEDQGLILQDRAKSDTKSTAFSFRASKELK 327
              +W   FR +HL TG+YLA          +++G  ++D     +K      +A +++ 
Sbjct: 295 GAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKR---QAGEKIM 351

Query: 328 EKLDS-SHKRDIEG---MGVPEIKYGD------SVCFVQHIASGLWVTYKAQDAKTSRLG 377
             L S  H  DI     +    ++  D      S   ++H+ +  WVT  +    T    
Sbjct: 352 YTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEER 411

Query: 378 PLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFVSGNNRTAAPITLPIE 437
           P+  K+            T Q  + +E+ A   +  +      F +  N+  A     +E
Sbjct: 412 PVMLKI-----------GTCQTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLE 460

Query: 438 E----------VLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLN 487
                      V + L+DLI +        +        +  + RQ L +E+ +LA V  
Sbjct: 461 NGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFG 520

Query: 488 CIDRLNVYNSVAHFAGIAREESG----MAWKEILNLLYKLLAALIRGNRNNCAQFSNNLD 543
            + +          + +  E+ G      +K +L L Y++L       R++   +  N +
Sbjct: 521 IL-KAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVL-------RHSQQDYRKNQE 572

Query: 544 WLISKLDRLESSSG--IL--EVLHCILTESPEALNL-IAEGHIKSIISLLDKHGRNHKVL 598
           ++      ++S  G  IL  + +  +L  + + L   I    I++ +SLL +  R  + L
Sbjct: 573 YIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLL-RRNREPRFL 631

Query: 599 DILCSLCLCNGVAVRANQNLICDNLLPRRN--LLLQTRLIN 637
           D L  LC+ N  A+   Q LIC  +L   N  +L+QT++++
Sbjct: 632 DYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVS 672



 Score = 80.1 bits (196), Expect = 5e-14
 Identities = 121/551 (21%), Positives = 209/551 (37%), Gaps = 149/551 (27%)

Query: 3618 QARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKE-KKD 3676
            Q  L + GA+E+V+ +I  +K +   +  E + LGIA+L GGN   Q      L E KK 
Sbjct: 1746 QCLLDKEGASELVIDVIVNTKNDR--IFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKS 1803

Query: 3677 AGFFQSLSGLMQSC-----SVLDLNAFERQNK---------AEGLGMVTEEGTLIVRE-- 3720
              FF+ L   M++      S + +N  +  NK           G  M   + TL ++E  
Sbjct: 1804 EKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGM 1863

Query: 3721 -----------------------------------------RGEKVLQNDEFT--RDLFR 3737
                                                       E+V  +      + + R
Sbjct: 1864 KGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILR 1923

Query: 3738 FLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDES 3797
            FLQLLCE HN + QNFLR Q  N T  N++  T+ +L  +  S +       G  ++   
Sbjct: 1924 FLQLLCENHNRELQNFLRNQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL--- 1973

Query: 3798 GQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQD 3857
            G +   K +A+  Q   SLTEY QGPC  NQ  +A                      + +
Sbjct: 1974 GLYINEKNVALVNQNLESLTEYCQGPCHENQTCIA----------------------THE 2011

Query: 3858 SSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFL 3917
            S+ I+++  L  +L D+                +GK  +D +++   N   +L       
Sbjct: 2012 SNGIDIIIAL--ILNDI--------------NPLGKYRMDLVLQLKNNASKLL------- 2048

Query: 3918 KLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYV 3977
                L   ++  + +   + + + +  +     +  Y Q      L C   D+    + V
Sbjct: 2049 ----LAIMESRHDSENAERILFNMRPRELVDVMKNAYNQG-----LECDHGDDEGGDDGV 2099

Query: 3978 DFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDP------AESVLNYFEPYLGR 4031
                      KD+G N+ +L   L+ H   +  L+ +L P       +  L Y+  +  +
Sbjct: 2100 S--------PKDVGHNIYILAHQLARH---NKLLQQMLKPGSDPDEGDEALKYYANHTAQ 2148

Query: 4032 IEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCED 4091
            IEI+   + +E++ F +         +   +ESK + +F+      +  K+  F    ED
Sbjct: 2149 IEIVRHDRTMEQIVFPVPNIC-----EYLTRESKCR-VFNTTERDEQGSKVNDFFQQTED 2202

Query: 4092 TIFEMQLASQI 4102
               EM+   +I
Sbjct: 2203 LYNEMKWQKKI 2213



 Score = 38.1 bits (87), Expect = 0.22
 Identities = 36/164 (21%), Positives = 69/164 (42%), Gaps = 24/164 (14%)

Query: 463  QNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYK 522
            QNK +     Q L K  G  ++VL+ +              I  E++     E++NL + 
Sbjct: 1195 QNK-KCRNQHQRLLKNMGAHSVVLDLLQ-------------IPYEKNDEKMNEVMNLAHT 1240

Query: 523  LLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGIL--EVLHCILTESPEALNLIAEGH 580
             L    RGN  N      +L+  +        + G+L  E +  I   +    N I+E  
Sbjct: 1241 FLQNFCRGNPQNQVLLHKHLNLFL--------TPGLLEAETMRHIFMNNYHLCNEISERV 1292

Query: 581  IKSIISLLDKHGRNHKVLDILCSLCLCNGVAVRANQNLICDNLL 624
            ++  +  ++ HGR+ + L  L ++   +G  V+  Q+++   L+
Sbjct: 1293 VQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELI 1336



 Score = 37.4 bits (85), Expect = 0.37
 Identities = 21/73 (28%), Positives = 38/73 (52%), Gaps = 2/73 (2%)

Query: 2047 IMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYFCRISRQ 2106
            + N K   QH  L++ +G H  V++++   +  EK+     +++     FL  FCR + Q
Sbjct: 1194 VQNKKCRNQHQRLLKNMGAHSVVLDLL--QIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQ 1251

Query: 2107 NQKAMFEHLSYLL 2119
            NQ  + +HL+  L
Sbjct: 1252 NQVLLHKHLNLFL 1264


>gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isoform 1
            [Homo sapiens]
          Length = 2710

 Score =  164 bits (414), Expect = 3e-39
 Identities = 90/288 (31%), Positives = 151/288 (52%), Gaps = 50/288 (17%)

Query: 4619 DNSFLYLAWYTTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4677
            D  FLY   Y  +  +G + + FF++  L D+    +TL  ++ SVT NG+ ++LT  L 
Sbjct: 2349 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2408

Query: 4678 AVVVYLYTVVAFNFFR-------------------------------------------- 4693
             ++VYL+++V + FF+                                            
Sbjct: 2409 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2468

Query: 4694 ----KFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD-PYEMYRIV 4748
                +     E + + +  C+ ++ C +  +  G+R+GGG+GD +  P+ + P    R++
Sbjct: 2469 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2528

Query: 4749 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGF 4808
            +D+ FFF VI+I+L +I G+IID F +LR ++++  E ++T CFICG+  D FD     F
Sbjct: 2529 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2588

Query: 4809 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 4856
            E H  +EHN+ +YL F++ +  KD TE+TG ESYV +M +ER  D+FP
Sbjct: 2589 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2636



 Score = 99.8 bits (247), Expect = 6e-20
 Identities = 127/568 (22%), Positives = 228/568 (40%), Gaps = 49/568 (8%)

Query: 105 YGHAVLLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEK 164
           YG+ + L H  S  YLT      +  +K A  V L E A  E  W+ I P  K RS G+ 
Sbjct: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175

Query: 165 VRIGDDLILVSVSSERYLHLS----VSN-GNIQVDASFMQTLWNVHPTCSGSSIEEGYLL 219
           V IGD ++L  V++ + LH S    V N G  +V++    T W +      S  ++  L 
Sbjct: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235

Query: 220 GGHVVRLFHGHDECLTIPSTDQNDSQH---RRIFYEAGGAGTRARSLWRVEPLRIS-WSG 275
           GG VVRLFH   E   +   +    QH   R    ++  + T +++LW VE ++     G
Sbjct: 236 GGDVVRLFHAEQEKF-LTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRG 294

Query: 276 SNIRWGQAFRLRHLTTGHYLALT-----EDQGLILQDRAKSDTKSTAFSFRASKE----- 325
               W   FR +HL TGHYLA       E++ L  Q     D  ++    R ++E     
Sbjct: 295 GAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYS 354

Query: 326 LKEKLDSSHKRDIEGMGVPEIKYGDSV------CFVQHIASGLWVTYKAQDAKTSRLGPL 379
           L    + +    I  +    ++ GDS+        ++H+ +  WV             P+
Sbjct: 355 LVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPV 414

Query: 380 KRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFVSGNNRTAAPITLPIEEV 439
             K+         +   +      E +      + + +    ++G              V
Sbjct: 415 MLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGS-IAGKLEKGTITQNERRSV 473

Query: 440 LQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVA 499
            + L+DL+ +        +   +    +  + RQ L +E+ +L  +   +     +    
Sbjct: 474 TKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQA--PFTDCG 531

Query: 500 HFAGIAREESG----MAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESS 555
               +  EE G      ++ I  L Y++L       R++   +  N +++  +   ++  
Sbjct: 532 DGPMLRLEELGDQRHAPFRHICRLCYRVL-------RHSQQDYRKNQEYIAKQFGFMQKQ 584

Query: 556 SG----ILEVLHCILTESPEALNL-IAEGHIKSIISLLDKHGRNHKVLDILCSLCLCNGV 610
            G      + +  +L  + + L   I    I + +SL+ K+ R  + LD L  LC+    
Sbjct: 585 IGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKN-REPRFLDYLSDLCVSMNK 643

Query: 611 AVRANQNLICDNLLPRRN--LLLQTRLI 636
           ++   Q LIC  +L   N  +L++T+L+
Sbjct: 644 SIPVTQELICKAVLNPTNADILIETKLV 671



 Score = 79.7 bits (195), Expect = 6e-14
 Identities = 110/494 (22%), Positives = 190/494 (38%), Gaps = 140/494 (28%)

Query: 3618 QARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKE-KKD 3676
            Q  L + GA+ +V+ +I  +  +   +  E++ L IA+L GGN  +Q      L E KK 
Sbjct: 1756 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1813

Query: 3677 AGFFQSLSGLMQSC-----SVLDLNAFERQNK---------AEGLGMVTEEGTLIVRERG 3722
              FF+     M+       + + +N  +  NK         A       E  T I  E  
Sbjct: 1814 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1873

Query: 3723 EKVLQNDEFTRDLF-------------------------------------------RFL 3739
            +++L+    TR  F                                           RFL
Sbjct: 1874 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1933

Query: 3740 QLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQ 3799
            QLLCE HN D QNFLR Q  N T  N++  T+ +L  +  S +       G  ++   G 
Sbjct: 1934 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1983

Query: 3800 HNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSS 3859
            +   K +A+  Q   SLTEY QGPC  NQ  +A                      + +S+
Sbjct: 1984 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2021

Query: 3860 QIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKL 3919
             I+++  L  +L D+                +GK+ +D ++E   N   +L         
Sbjct: 2022 GIDIITAL--ILNDI--------------NPLGKKRMDLVLELKNNASKLL--------- 2056

Query: 3920 KDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYVDF 3979
              L   ++  + +   + + + +  +     +K Y Q E++F     E  EN        
Sbjct: 2057 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-----EDGENG------- 2102

Query: 3980 VDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDP-----AESVLNYFEPYLGRIEI 4034
             D    P +++G N+ +L   L+ H   +  L+ +L P      +  L ++  +  +IEI
Sbjct: 2103 EDGAASP-RNVGHNIYILAHQLARH---NKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2158

Query: 4035 MGGAKKIERVYFEI 4048
            +   + +E++ F +
Sbjct: 2159 VRLDRTMEQIVFPV 2172


>gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isoform 2
            [Homo sapiens]
          Length = 2695

 Score =  164 bits (414), Expect = 3e-39
 Identities = 90/288 (31%), Positives = 151/288 (52%), Gaps = 50/288 (17%)

Query: 4619 DNSFLYLAWYTTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4677
            D  FLY   Y  +  +G + + FF++  L D+    +TL  ++ SVT NG+ ++LT  L 
Sbjct: 2334 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2393

Query: 4678 AVVVYLYTVVAFNFFR-------------------------------------------- 4693
             ++VYL+++V + FF+                                            
Sbjct: 2394 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2453

Query: 4694 ----KFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD-PYEMYRIV 4748
                +     E + + +  C+ ++ C +  +  G+R+GGG+GD +  P+ + P    R++
Sbjct: 2454 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2513

Query: 4749 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGF 4808
            +D+ FFF VI+I+L +I G+IID F +LR ++++  E ++T CFICG+  D FD     F
Sbjct: 2514 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2573

Query: 4809 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 4856
            E H  +EHN+ +YL F++ +  KD TE+TG ESYV +M +ER  D+FP
Sbjct: 2574 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2621



 Score = 99.4 bits (246), Expect = 8e-20
 Identities = 126/558 (22%), Positives = 225/558 (40%), Gaps = 44/558 (7%)

Query: 105 YGHAVLLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEK 164
           YG+ + L H  S  YLT      +  +K A  V L E A  E  W+ I P  K RS G+ 
Sbjct: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175

Query: 165 VRIGDDLILVSVSSERYLHLS----VSN-GNIQVDASFMQTLWNVHPTCSGSSIEEGYLL 219
           V IGD ++L  V++ + LH S    V N G  +V++    T W +      S  ++  L 
Sbjct: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235

Query: 220 GGHVVRLFHGHDECLTIPSTDQNDSQH---RRIFYEAGGAGTRARSLWRVEPLRIS-WSG 275
           GG VVRLFH   E   +   +    QH   R    ++  + T +++LW VE ++     G
Sbjct: 236 GGDVVRLFHAEQEKF-LTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRG 294

Query: 276 SNIRWGQAFRLRHLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHK 335
               W   FR +HL TGHYLA   D     QD ++S  ++       S  L    + +  
Sbjct: 295 GAGYWNSLFRFKHLATGHYLAAEVDPD---QDASRSRLRNAQEKMVYS--LVSVPEGNDI 349

Query: 336 RDIEGMGVPEIKYGDSV------CFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEG 389
             I  +    ++ GDS+        ++H+ +  WV             P+  K+      
Sbjct: 350 SSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVK 409

Query: 390 HMDDGLTLQRCQREESQAARIIRNTTALFSQFVSGNNRTAAPITLPIEEVLQTLQDLIAY 449
              +   +      E +      + + +    ++G              V + L+DL+ +
Sbjct: 410 EDKEAFAIVPVSPAEVRDLDFANDASKVLGS-IAGKLEKGTITQNERRSVTKLLEDLVYF 468

Query: 450 FQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREES 509
                   +   +    +  + RQ L +E+ +L  +   +     +        +  EE 
Sbjct: 469 VTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQA--PFTDCGDGPMLRLEEL 526

Query: 510 G----MAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSG----ILEV 561
           G      ++ I  L Y++L       R++   +  N +++  +   ++   G      + 
Sbjct: 527 GDQRHAPFRHICRLCYRVL-------RHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDT 579

Query: 562 LHCILTESPEALNL-IAEGHIKSIISLLDKHGRNHKVLDILCSLCLCNGVAVRANQNLIC 620
           +  +L  + + L   I    I + +SL+ K+ R  + LD L  LC+    ++   Q LIC
Sbjct: 580 ITALLHNNRKLLEKHITAAEIDTFVSLVRKN-REPRFLDYLSDLCVSMNKSIPVTQELIC 638

Query: 621 DNLLPRRN--LLLQTRLI 636
             +L   N  +L++T+L+
Sbjct: 639 KAVLNPTNADILIETKLV 656



 Score = 79.7 bits (195), Expect = 6e-14
 Identities = 110/494 (22%), Positives = 190/494 (38%), Gaps = 140/494 (28%)

Query: 3618 QARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKE-KKD 3676
            Q  L + GA+ +V+ +I  +  +   +  E++ L IA+L GGN  +Q      L E KK 
Sbjct: 1741 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1798

Query: 3677 AGFFQSLSGLMQSC-----SVLDLNAFERQNK---------AEGLGMVTEEGTLIVRERG 3722
              FF+     M+       + + +N  +  NK         A       E  T I  E  
Sbjct: 1799 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1858

Query: 3723 EKVLQNDEFTRDLF-------------------------------------------RFL 3739
            +++L+    TR  F                                           RFL
Sbjct: 1859 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1918

Query: 3740 QLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQ 3799
            QLLCE HN D QNFLR Q  N T  N++  T+ +L  +  S +       G  ++   G 
Sbjct: 1919 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1968

Query: 3800 HNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSS 3859
            +   K +A+  Q   SLTEY QGPC  NQ  +A                      + +S+
Sbjct: 1969 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2006

Query: 3860 QIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKL 3919
             I+++  L  +L D+                +GK+ +D ++E   N   +L         
Sbjct: 2007 GIDIITAL--ILNDI--------------NPLGKKRMDLVLELKNNASKLL--------- 2041

Query: 3920 KDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYVDF 3979
              L   ++  + +   + + + +  +     +K Y Q E++F     E  EN        
Sbjct: 2042 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-----EDGENG------- 2087

Query: 3980 VDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDP-----AESVLNYFEPYLGRIEI 4034
             D    P +++G N+ +L   L+ H   +  L+ +L P      +  L ++  +  +IEI
Sbjct: 2088 EDGAASP-RNVGHNIYILAHQLARH---NKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2143

Query: 4035 MGGAKKIERVYFEI 4048
            +   + +E++ F +
Sbjct: 2144 VRLDRTMEQIVFPV 2157


>gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo
            sapiens]
          Length = 2671

 Score =  160 bits (405), Expect = 3e-38
 Identities = 96/287 (33%), Positives = 151/287 (52%), Gaps = 49/287 (17%)

Query: 4619 DNSFLYLAWYTTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4677
            D  FLY   Y   SVLG + +  F++  L D+    +TL  ++ SVT NG+ ++LT  L 
Sbjct: 2317 DMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLA 2376

Query: 4678 AVVVYLYTVVAFNFFRKFY---------NKS----------------------------- 4699
             ++VYL+++V F F +  +         N S                             
Sbjct: 2377 LILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGL 2436

Query: 4700 ------EDD---DEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEM-YRIVF 4749
                  E+D   D  +  CD ++ C +  M  G+R GGG+GD +  P+ D      R+V+
Sbjct: 2437 SVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVY 2496

Query: 4750 DITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFE 4809
            D+ FFF VI+I+L +I G+IID F +LR ++++  E ++T CFICG+  D FD     FE
Sbjct: 2497 DLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE 2556

Query: 4810 THTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 4856
             H   EHN+ NYL+F++ +  K++T++TG ESYV +M + +  D+FP
Sbjct: 2557 EHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFP 2603



 Score = 95.9 bits (237), Expect = 9e-19
 Identities = 141/622 (22%), Positives = 245/622 (39%), Gaps = 86/622 (13%)

Query: 65  VCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYLTCLT 124
           + + VL Q L   A  E   N  EN       G     + YG  + L H  S  YLT   
Sbjct: 84  IADVVLLQKLQHAAQMEQKQNDTENK---KVHGD---VVKYGSVIQLLHMKSNKYLTVNK 137

Query: 125 TSRSQTDKLAFDVGLREHATG-EACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLH 183
              +  +K A  V L   ATG E  W  I P  K RS G+ V +GD +IL  V++ + LH
Sbjct: 138 RLPALLEKNAMRVTL--DATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLH 195

Query: 184 -----LSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPS 238
                LS + G  +V++    T W ++         E  L GG VVRLFH   E      
Sbjct: 196 ASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCD 255

Query: 239 TDQNDSQ--HRRIFYEAGGAGTRARSLWRVEPLRIS-WSGSNIRWGQAFRLRHLTTGHYL 295
             +   Q   R    ++  + T + +LW VE +      G    W   +R +HL TG+YL
Sbjct: 256 EYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYL 315

Query: 296 ALTEDQGLILQDRAKSDTKSTAFSFR-------ASKELKEKLDS-SHKRDIEGM------ 341
           A  E+          SD K+     +       A +++K  L +  H  DI  +      
Sbjct: 316 AAEENPS---YKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPT 372

Query: 342 ---GVPEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQ 398
                      +S   ++H+ +  W+             P++              L L 
Sbjct: 373 TLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIR--------------LMLG 418

Query: 399 RCQREESQAARIIRNTTALFSQFVSGNNRTAAPITLPIEE-------------VLQTLQD 445
            C  +E + A  I +      + +   N  ++ +   +E+             V+Q L+D
Sbjct: 419 TCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLED 478

Query: 446 LIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVAHFAGIA 505
           L+ +        ++       +  + RQ L +E+ +L  V   +     +        + 
Sbjct: 479 LVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKA--PFREKGGEGPLV 536

Query: 506 R-----EESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSG--I 558
           R     ++    ++ +  L Y++L       R++   +  N + +  +   ++S  G  I
Sbjct: 537 RLEELSDQKNAPYQHMFRLCYRVL-------RHSQEDYRKNQEHIAKQFGMMQSQIGYDI 589

Query: 559 L--EVLHCILTESPEALNL-IAEGHIKSIISLLDKHGRNHKVLDILCSLCLCNGVAVRAN 615
           L  + +  +L  + + L   I +  +++ +SL+ K+ R  + LD L  LC+ N +A+   
Sbjct: 590 LAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKN-REPRFLDYLSDLCVSNHIAIPVT 648

Query: 616 QNLICDNLLPRRN--LLLQTRL 635
           Q LIC  +L  +N  +L++T L
Sbjct: 649 QELICKCVLDPKNSDILIRTEL 670



 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 68/248 (27%), Positives = 111/248 (44%), Gaps = 53/248 (21%)

Query: 3618 QARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYL-KEKKD 3676
            Q RL + GA ++V  +I+++K E   +  E++ L I +L+GGN  +Q+   + +  +KK 
Sbjct: 1725 QCRLDKEGATKLVCDLITSTKNEK--IFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKS 1782

Query: 3677 AGFFQSLSGLMQ----------SCSVLDLNAFERQNKAE--------------------- 3705
              FF+ L   M+          + ++ DL +   +++                       
Sbjct: 1783 ERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRY 1842

Query: 3706 GLGMVTEEGTLIVRERGEKVLQNDEFT-----RDLFRFLQLLCEGHNSDFQNFLRTQMGN 3760
             LG     G     E  E+V  ++  T     + + RFLQLLCE HN D QNFLR Q  N
Sbjct: 1843 SLGPSLRRG----HEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NN 1897

Query: 3761 TTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYI 3820
             T  N++  T+ +L  +  S +       G  ++   G +     + +  Q   +LTEY 
Sbjct: 1898 KTNYNLVCETLQFLDIMCGSTT------GGLGLL---GLYINEDNVGLVIQTLETLTEYC 1948

Query: 3821 QGPCIGNQ 3828
            QGPC  NQ
Sbjct: 1949 QGPCHENQ 1956


>gi|37588869 ring finger protein 123 [Homo sapiens]
          Length = 1314

 Score = 77.0 bits (188), Expect = 4e-13
 Identities = 35/100 (35%), Positives = 58/100 (58%), Gaps = 2/100 (2%)

Query: 1073 FFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADD--QAFVFEGNRGQR 1130
            F  +  +  V  GKW +E  + + G M++GW    CR + E G  D   ++ ++GNR ++
Sbjct: 121  FGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRK 180

Query: 1131 WHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLIT 1170
            W+  +  +G+ W  GD+V C+I+LDD ++ F LNG  L T
Sbjct: 181  WNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGT 220



 Score = 47.0 bits (110), Expect = 5e-04
 Identities = 45/156 (28%), Positives = 69/156 (44%), Gaps = 32/156 (20%)

Query: 659 KWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDG-- 716
           KW +E++I        +    +++GW + S               GVGD   SY +DG  
Sbjct: 134 KWLYEVLI--------SSQGLMQIGWCTISCRFNQE--------EGVGDTHNSYAYDGNR 177

Query: 717 LHLWSGRIPRAVASINQ-HLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGL- 774
           +  W+      V + N      + D+VSC +DL   ++SF +NG  +   FEN +  GL 
Sbjct: 178 VRKWN------VTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSR-GLG 230

Query: 775 --FFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAP 808
             +FP +S S    V F  G R   +   P +GY P
Sbjct: 231 MAYFPAISLSFKESVAFNFGSRPLRY---PVAGYRP 263



 Score = 33.1 bits (74), Expect = 6.9
 Identities = 19/52 (36%), Positives = 25/52 (48%), Gaps = 3/52 (5%)

Query: 1411 IGCLVDLAMGMLSFSANGKELGTCYQVEP---NTKVFPAVFLQPTSTSLFQF 1459
            + CL+DL  G LSF  NG  LGT ++          FPA+ L    +  F F
Sbjct: 198  VSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNF 249


>gi|45387949 ring finger and SPRY domain containing 1 [Homo sapiens]
          Length = 576

 Score = 62.8 bits (151), Expect = 8e-09
 Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 6/110 (5%)

Query: 1069 DKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCR----PDVELGADDQAFVFE 1124
            D   F  V  ++ V +G WY+E  VVT G M++GWA    +        +G D+ +  ++
Sbjct: 343  DASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYD 402

Query: 1125 GNRGQRWH--QGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNK 1172
            G R   W+  +   +    W+ GD VG +++L++  MIF LNG  L   K
Sbjct: 403  GCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEK 452



 Score = 37.0 bits (84), Expect = 0.48
 Identities = 42/166 (25%), Positives = 69/166 (41%), Gaps = 22/166 (13%)

Query: 660 WYFELIIDQVDPFLTAEPTHLRVGWAS-SSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLH 718
           WY+E+ +             +++GWA+  S +  + G        G+GDD YS  +DG  
Sbjct: 361 WYYEVTV--------VTSGVMQIGWATRDSKFLNHEG-------YGIGDDEYSCAYDGCR 405

Query: 719 LWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENF-NTDGLFFP 777
                  R+   I+    +  D V   LDL    + F +NG  +    + F +T   FF 
Sbjct: 406 QLIWYNARSKPHIHP-CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFA 464

Query: 778 VMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPC--YEALLPKEKMRL 821
             SF +  +  F  G +   FK+ P   ++    Y  L  +EK+ L
Sbjct: 465 AASFMSYQQCEFNFGAK--PFKYPPSMKFSTFNDYAFLTAEEKIIL 508


>gi|157412282 ash2-like isoform b [Homo sapiens]
          Length = 534

 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 31/102 (30%), Positives = 51/102 (50%), Gaps = 10/102 (9%)

Query: 1065 KVSIDKIR------FFRVERSYAVRSGKWYFEF---EVVTGGDMRVGWARPGCRPDVELG 1115
            K+S D++       +  V  S+ VR G WYFE    E+      R+GW++P       LG
Sbjct: 299  KISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLG 358

Query: 1116 ADDQAFVFEGNRGQRWHQGSG-YFGRTWQPGDVVGCMINLDD 1156
             D  ++ +   +G ++HQ  G ++   +  GDV+G  INL +
Sbjct: 359  YDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPE 400


>gi|157412280 ash2-like isoform a [Homo sapiens]
          Length = 628

 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 31/102 (30%), Positives = 51/102 (50%), Gaps = 10/102 (9%)

Query: 1065 KVSIDKIR------FFRVERSYAVRSGKWYFEF---EVVTGGDMRVGWARPGCRPDVELG 1115
            K+S D++       +  V  S+ VR G WYFE    E+      R+GW++P       LG
Sbjct: 393  KISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLG 452

Query: 1116 ADDQAFVFEGNRGQRWHQGSG-YFGRTWQPGDVVGCMINLDD 1156
             D  ++ +   +G ++HQ  G ++   +  GDV+G  INL +
Sbjct: 453  YDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPE 494


>gi|40538736 RAN binding protein 10 [Homo sapiens]
          Length = 620

 Score = 46.2 bits (108), Expect = 8e-04
 Identities = 28/89 (31%), Positives = 48/89 (53%), Gaps = 5/89 (5%)

Query: 1085 GKWYFEFEVVTGGD---MRVGWARPGCRPDVELGADDQAFVFEGNRGQRW-HQGSGY-FG 1139
            G +YFE ++V+ G    M +G +  G   +   G D  ++ + G+ G  +   G+G  +G
Sbjct: 101  GIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYG 160

Query: 1140 RTWQPGDVVGCMINLDDASMIFTLNGELL 1168
             T+  GDV+GC +NL + +  +T NG  L
Sbjct: 161  PTFTTGDVIGCCVNLINGTCFYTKNGHSL 189


>gi|39812378 RAN binding protein 9 [Homo sapiens]
          Length = 729

 Score = 45.4 bits (106), Expect = 0.001
 Identities = 28/89 (31%), Positives = 48/89 (53%), Gaps = 5/89 (5%)

Query: 1085 GKWYFEFEVVTGGD---MRVGWARPGCRPDVELGADDQAFVFEGNRGQRW-HQGSGY-FG 1139
            G +YFE ++V+ G    M +G +  G   +   G D  ++ + G+ G  +   G+G  +G
Sbjct: 213  GIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYG 272

Query: 1140 RTWQPGDVVGCMINLDDASMIFTLNGELL 1168
             T+  GDV+GC +NL + +  +T NG  L
Sbjct: 273  PTFTTGDVIGCCVNLINNTCFYTKNGHSL 301


>gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2 [Homo
            sapiens]
          Length = 747

 Score = 45.4 bits (106), Expect = 0.001
 Identities = 34/101 (33%), Positives = 50/101 (49%), Gaps = 16/101 (15%)

Query: 1079 SYAVRSGKWYFEFEVVTGGDM----------RVGWARPGCRPDVELGADDQAFVFEGNRG 1128
            +Y V  GK  FE +V     M          RVGW+    RP  +LG D+ ++ F+G RG
Sbjct: 284  TYGVTKGKVCFEAKVTQNLPMKEGCTEVSLLRVGWSVDFSRP--QLGEDEFSYGFDG-RG 340

Query: 1129 QRWHQGS-GYFGRTWQPGDVVGCMINL--DDASMIFTLNGE 1166
             +   G    FG+T+   DV+GC  N   ++  + F+ NGE
Sbjct: 341  LKAENGQFEEFGQTFGENDVIGCFANFETEEVELSFSKNGE 381


>gi|4826686 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [Homo sapiens]
          Length = 740

 Score = 44.3 bits (103), Expect = 0.003
 Identities = 33/128 (25%), Positives = 56/128 (43%), Gaps = 9/128 (7%)

Query: 1085 GKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQGSGYFGRTWQP 1144
            GK Y+E      G  RVGW+    +  ++LG D   F F G   +  ++    +G  +  
Sbjct: 131  GKHYYEVSCHDQGLCRVGWST--MQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTM 188

Query: 1145 GDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGRMNLG 1204
             D +GC +++D   + F+ NG+ L    G       +       P C L  +++ + N G
Sbjct: 189  HDTIGCYLDIDKGHVKFSKNGKDL----GLAFEIPPHMKNQALFPACVLKNAEL-KFNFG 243

Query: 1205 TDASTFKF 1212
             +   FKF
Sbjct: 244  EE--EFKF 249



 Score = 40.0 bits (92), Expect = 0.057
 Identities = 18/43 (41%), Positives = 28/43 (65%), Gaps = 3/43 (6%)

Query: 1411 IGCLVDLAMGMLSFSANGKELGTCYQVEPNTK---VFPAVFLQ 1450
            IGC +D+  G + FS NGK+LG  +++ P+ K   +FPA  L+
Sbjct: 192  IGCYLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLK 234


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
            sapiens]
          Length = 916

 Score = 42.7 bits (99), Expect = 0.009
 Identities = 45/160 (28%), Positives = 72/160 (45%), Gaps = 22/160 (13%)

Query: 4243 IHDDTMEAERAEVMEP--GITTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGL 4300
            I +  +E E++E+ E    IT EL   +K EK +     +      ++E + K  P    
Sbjct: 457  IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 516

Query: 4301 --------GDLSEIIGKDEPPTLESTVQKKRKAQAAEMKAANEAEGKVESEKADMEDGE- 4351
                    G+  E  G++E    E    +  K+  AE +  +E EG  E E+ + E+GE 
Sbjct: 517  APEVKEEEGEKEEEEGQEE----EEEEDEGAKSDQAE-EGGSEKEGSSEKEEGEQEEGET 571

Query: 4352 ------KEDKDKEEEQAEYLWTEVTKKKKRRCGQKVEKPE 4385
                  +E + KEE++ E    EV  K++     KVEKPE
Sbjct: 572  EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 611



 Score = 37.4 bits (85), Expect = 0.37
 Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 12/174 (6%)

Query: 3461 LEQVEQPLRSKKAVWHKLLSKQRKR-AVVACFRMAPLYNLPRHRSINLFLHGYQRFWIET 3519
            L  V+  L  + A + KLL  +  R +  A     PLY    HR         Q+  +E 
Sbjct: 387  LLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYT---HRPPITISSKIQKPKVEA 443

Query: 3520 EEYSFEEKLVQDLAKSPKVEEEEEEETEKQPDPLHQIILYFSRNALTERSKLEDDP---- 3575
             +   + K V+++ +  KVE+E+ E  E       ++ +           + E++P    
Sbjct: 444  PKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEE 503

Query: 3576 -LYTSYSSMMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLYQQARLHERGAAE 3628
                +  S +  +    ++EE ++++E+  EE+E E +     QA   E G +E
Sbjct: 504  EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA---EEGGSE 554


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
            sapiens]
          Length = 540

 Score = 42.7 bits (99), Expect = 0.009
 Identities = 45/160 (28%), Positives = 72/160 (45%), Gaps = 22/160 (13%)

Query: 4243 IHDDTMEAERAEVMEP--GITTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGL 4300
            I +  +E E++E+ E    IT EL   +K EK +     +      ++E + K  P    
Sbjct: 81   IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 140

Query: 4301 --------GDLSEIIGKDEPPTLESTVQKKRKAQAAEMKAANEAEGKVESEKADMEDGE- 4351
                    G+  E  G++E    E    +  K+  AE +  +E EG  E E+ + E+GE 
Sbjct: 141  APEVKEEEGEKEEEEGQEE----EEEEDEGAKSDQAE-EGGSEKEGSSEKEEGEQEEGET 195

Query: 4352 ------KEDKDKEEEQAEYLWTEVTKKKKRRCGQKVEKPE 4385
                  +E + KEE++ E    EV  K++     KVEKPE
Sbjct: 196  EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 235



 Score = 37.4 bits (85), Expect = 0.37
 Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 12/174 (6%)

Query: 3461 LEQVEQPLRSKKAVWHKLLSKQRKR-AVVACFRMAPLYNLPRHRSINLFLHGYQRFWIET 3519
            L  V+  L  + A + KLL  +  R +  A     PLY    HR         Q+  +E 
Sbjct: 11   LLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYT---HRPPITISSKIQKPKVEA 67

Query: 3520 EEYSFEEKLVQDLAKSPKVEEEEEEETEKQPDPLHQIILYFSRNALTERSKLEDDP---- 3575
             +   + K V+++ +  KVE+E+ E  E       ++ +           + E++P    
Sbjct: 68   PKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEE 127

Query: 3576 -LYTSYSSMMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLYQQARLHERGAAE 3628
                +  S +  +    ++EE ++++E+  EE+E E +     QA   E G +E
Sbjct: 128  EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA---EEGGSE 178


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 41.2 bits (95), Expect = 0.025
 Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 2/114 (1%)

Query: 4272 KGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTL--ESTVQKKRKAQAAE 4329
            K D  I ++      +KE   K  P     +++E    D  P    E TV+K+ K +  +
Sbjct: 589  KKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPED 648

Query: 4330 MKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQKVEK 4383
             K   E   K  ++K D    +KE+K K+EE  + +  E+ K++K+   ++V+K
Sbjct: 649  KKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKK 702



 Score = 35.0 bits (79), Expect = 1.8
 Identities = 24/81 (29%), Positives = 43/81 (53%), Gaps = 10/81 (12%)

Query: 4305 EIIGKDEPPTLESTVQKKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEY 4364
            E+  K+EP  +++ V +K   QA ++K     E  V+ E     + +KE+K+K ++    
Sbjct: 606  EVPSKEEPSPVKAEVAEK---QATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKK---- 658

Query: 4365 LWTEVTKKKKRRCGQKVEKPE 4385
               EV KK+ +   +K EKP+
Sbjct: 659  ---EVAKKEDKTPIKKEEKPK 676


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 40.4 bits (93), Expect = 0.043
 Identities = 25/79 (31%), Positives = 42/79 (53%), Gaps = 1/79 (1%)

Query: 4310 DEPPTLESTVQKKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEV 4369
            +E  +L   ++K+    + E +   E E + E E  + E+  KE+++ EE+Q E    E 
Sbjct: 2228 EEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEK 2287

Query: 4370 TKKKKRRCGQKV-EKPEAF 4387
             KKKK +  ++V EK E F
Sbjct: 2288 KKKKKEKKKEEVQEKEEVF 2306



 Score = 38.9 bits (89), Expect = 0.13
 Identities = 30/103 (29%), Positives = 53/103 (51%), Gaps = 9/103 (8%)

Query: 3517 IETEEYSFEE--KLVQDLAKSPKVEEEEEEETEKQPDPLHQIILYFSRNALTERSKLED- 3573
            +E+EE+  EE   L+ +L K   +  EEEEE E++ +   + +    R    ER + E+ 
Sbjct: 2220 VESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEV----REEEEERKEEEEG 2275

Query: 3574 DPLYTSYSSMMAKSCQSGEDEEEDEDKEKTFEEKE--MEKQKT 3614
            +           K  +  + +EE ++KE+ FEEKE  M +++T
Sbjct: 2276 EEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEET 2318



 Score = 37.4 bits (85), Expect = 0.37
 Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 8/124 (6%)

Query: 3518 ETEEYSFEEKLVQDLAKSPKVEEEEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLY 3577
            E E    EE+  +++ +  +  +EEEE  EKQ +   +      +    E  + +++   
Sbjct: 2248 EEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFE 2307

Query: 3578 TSYSSMMAKSCQSGEDEEEDED----KEKTFEEKEM---EKQKTLYQQARLHERGAAEMV 3630
                 M  +  +S  DEEE+E+    +E+   EKE+   EKQ  L +Q R   RG  E V
Sbjct: 2308 EKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRG-RERV 2366

Query: 3631 LQMI 3634
            L ++
Sbjct: 2367 LSIL 2370



 Score = 33.5 bits (75), Expect = 5.3
 Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 5/99 (5%)

Query: 4036 GGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFE 4095
            GG ++ E + F +    R + E  +  + K +F   V     E E  E F    E  + E
Sbjct: 2182 GGIEEEEVIPF-LKRRWRKRKEAKRGDKPKEKFSSQV----DEVESEEHFSEEMESLLDE 2236

Query: 4096 MQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDG 4134
            ++    +S  +  +R EEEE +E+     E   +EEE+G
Sbjct: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEG 2275


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 40.0 bits (92), Expect = 0.057
 Identities = 42/182 (23%), Positives = 75/182 (41%), Gaps = 13/182 (7%)

Query: 423 SGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGML 482
           SGNN  +     P+ ++LQT Q  +   +    + R    + +L   +NR+ L +++  +
Sbjct: 192 SGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQI 251

Query: 483 ALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYK--LLAALIRGNRNNCAQFSN 540
           A++   IDRL + N         +  S +  KE+  L  K   L   +      C     
Sbjct: 252 AMMQQRIDRLALLNE-------KQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKT 304

Query: 541 NLDWLISKLDRLESSSGILEV----LHCILTESPEALNLIAEGHIKSIISLLDKHGRNHK 596
               +  K+++L   +G L          L +  +ALN + E H K+    L+K  +  K
Sbjct: 305 EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEK 364

Query: 597 VL 598
            L
Sbjct: 365 EL 366


>gi|55956788 nucleolin [Homo sapiens]
          Length = 710

 Score = 39.3 bits (90), Expect = 0.097
 Identities = 26/87 (29%), Positives = 45/87 (51%), Gaps = 11/87 (12%)

Query: 4311 EPPTLESTVQK-KRKAQAAEMKAANEAEGKVESE----------KADMEDGEKEDKDKEE 4359
            E   +E+T  K K+ A+   +KA N AE + E E          + D +D +++D+++EE
Sbjct: 207  EEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEE 266

Query: 4360 EQAEYLWTEVTKKKKRRCGQKVEKPEA 4386
            E+ E    E   K+K+   ++   PEA
Sbjct: 267  EEEEEPVKEAPGKRKKEMAKQKAAPEA 293


>gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapiens]
          Length = 123

 Score = 39.3 bits (90), Expect = 0.097
 Identities = 23/75 (30%), Positives = 40/75 (53%)

Query: 4309 KDEPPTLESTVQKKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTE 4368
            K++    ++   +KRK +  E K       K + E+   E+ E+E+++KEEE+ E     
Sbjct: 38   KEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRR 97

Query: 4369 VTKKKKRRCGQKVEK 4383
              KKK+RR  ++ EK
Sbjct: 98   KKKKKRRRKEEEEEK 112



 Score = 36.2 bits (82), Expect = 0.82
 Identities = 25/102 (24%), Positives = 50/102 (49%), Gaps = 3/102 (2%)

Query: 3525 EEKLVQDLAKSPKVEEEEEEE---TEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYS 3581
            ++K  ++  ++ + EEEEE+E    EK+ +   +           +R + E++       
Sbjct: 6    KKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRK 65

Query: 3582 SMMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLYQQARLHE 3623
                K  +  E+EEE+E++EK  EEKE  +++   ++ R  E
Sbjct: 66   RKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKE 107



 Score = 35.8 bits (81), Expect = 1.1
 Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 4/70 (5%)

Query: 4320 QKKRKAQAAEMKAANEAEGKVES----EKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKR 4375
            +KK+K +  E +   E E K       +K + E+ E+E++++EEE+ E    E  ++KK+
Sbjct: 41   EKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKK 100

Query: 4376 RCGQKVEKPE 4385
            +  ++ E+ E
Sbjct: 101  KKRRRKEEEE 110



 Score = 35.8 bits (81), Expect = 1.1
 Identities = 21/59 (35%), Positives = 34/59 (57%), Gaps = 2/59 (3%)

Query: 4320 QKKRKAQAAEMKAANEAEGKVESEKADMEDGEKED--KDKEEEQAEYLWTEVTKKKKRR 4376
            +KKRK +  + K   E E + E E+ + E+ EKE+  + K++++      E  KKKKRR
Sbjct: 59   EKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRR 117



 Score = 32.7 bits (73), Expect = 9.0
 Identities = 21/71 (29%), Positives = 36/71 (50%), Gaps = 7/71 (9%)

Query: 4320 QKKRKAQAAEMKAANEAEGKVESE-------KADMEDGEKEDKDKEEEQAEYLWTEVTKK 4372
            +KK+K +  E +   E E + E E       K   ++ EK+ K KE E+ +    E  K+
Sbjct: 3    KKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKR 62

Query: 4373 KKRRCGQKVEK 4383
            K++R  +K E+
Sbjct: 63   KRKRKKKKEEE 73


>gi|169167243 PREDICTED: similar to myosin regulatory light chain
            MRCL2 [Homo sapiens]
          Length = 377

 Score = 38.9 bits (89), Expect = 0.13
 Identities = 34/143 (23%), Positives = 61/143 (42%), Gaps = 10/143 (6%)

Query: 3857 DSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMF 3916
            D SQI+  KE  +++       +S  + + +  ++GK   D  +++  N       F M 
Sbjct: 232  DQSQIQEFKEAFNMIDQNRDGFISKEDLHGMLASLGKNPTDACLDAVMNEAPGPINFTML 291

Query: 3917 LKL--KDLTSSD-------TFKEYDPDGKGIISKKEFQKAMEGQ-KQYTQSEIDFLLSCA 3966
            L +  K L  +D        F  +D +  G I +   ++ +     Q+T  E+D L + A
Sbjct: 292  LAMFGKKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTVGDQFTDEEVDELYTEA 351

Query: 3967 EADENDMFNYVDFVDRFHEPAKD 3989
              D+   FNY++F        KD
Sbjct: 352  SIDKKGNFNYIEFTSILKHGVKD 374


>gi|190014636 hypothetical protein LOC286262 isoform 2 [Homo sapiens]
          Length = 678

 Score = 38.9 bits (89), Expect = 0.13
 Identities = 41/155 (26%), Positives = 60/155 (38%), Gaps = 48/155 (30%)

Query: 4008 DSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQ 4067
            +    CLL P    L    P +  IE++GG       Y  + +S  T+            
Sbjct: 470  EEEASCLLGPT---LKKRYPTVHEIEVIGG-------YLALQKSCLTK------------ 507

Query: 4068 FIFDVVNEGGEQEKMELFVNFCE-DTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEI 4126
                    G  ++KM++  N     T FE    S + + +  D+ EEEEE+E+       
Sbjct: 508  -------AGSSRKKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEE----- 555

Query: 4127 AGEEEEDGSLEPASAFAMACASVKRNVTDFLKRAT 4161
              EEEE+GS      FA+           FL RAT
Sbjct: 556  --EEEEEGSGSEEKPFAL-----------FLPRAT 577


>gi|190014638 hypothetical protein LOC286262 isoform 1 [Homo sapiens]
          Length = 650

 Score = 38.9 bits (89), Expect = 0.13
 Identities = 41/155 (26%), Positives = 60/155 (38%), Gaps = 48/155 (30%)

Query: 4008 DSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQ 4067
            +    CLL P    L    P +  IE++GG       Y  + +S  T+            
Sbjct: 470  EEEASCLLGPT---LKKRYPTVHEIEVIGG-------YLALQKSCLTK------------ 507

Query: 4068 FIFDVVNEGGEQEKMELFVNFCE-DTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEI 4126
                    G  ++KM++  N     T FE    S + + +  D+ EEEEE+E+       
Sbjct: 508  -------AGSSRKKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEE----- 555

Query: 4127 AGEEEEDGSLEPASAFAMACASVKRNVTDFLKRAT 4161
              EEEE+GS      FA+           FL RAT
Sbjct: 556  --EEEEEGSGSEEKPFAL-----------FLPRAT 577


>gi|88981341 PREDICTED: similar to myosin regulatory light chain MRCL2
            [Homo sapiens]
          Length = 377

 Score = 38.5 bits (88), Expect = 0.16
 Identities = 34/143 (23%), Positives = 61/143 (42%), Gaps = 10/143 (6%)

Query: 3857 DSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMF 3916
            D SQI+  KE  +++       +S  + + +  ++GK   D  +++  N       F M 
Sbjct: 232  DQSQIQEFKEAFNMIDQNRDGFISKEDLHGMLASLGKNPTDACLDAVMNEAPGPINFTML 291

Query: 3917 LKL--KDLTSSD-------TFKEYDPDGKGIISKKEFQKAMEGQ-KQYTQSEIDFLLSCA 3966
            L +  K L  +D        F  +D +  G I +   ++ +     Q+T  E+D L + A
Sbjct: 292  LAMFGKKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTVGDQFTDEEVDELYTEA 351

Query: 3967 EADENDMFNYVDFVDRFHEPAKD 3989
              D+   FNY++F        KD
Sbjct: 352  PIDKKGNFNYIEFTSILKHGVKD 374


>gi|51464364 PREDICTED: similar to myosin regulatory light chain MRCL2
            [Homo sapiens]
          Length = 377

 Score = 38.5 bits (88), Expect = 0.16
 Identities = 34/143 (23%), Positives = 61/143 (42%), Gaps = 10/143 (6%)

Query: 3857 DSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMF 3916
            D SQI+  KE  +++       +S  + + +  ++GK   D  +++  N       F M 
Sbjct: 232  DQSQIQEFKEAFNMIDQNRDGFISKEDLHGMLASLGKNPTDACLDAVMNEAPGPINFTML 291

Query: 3917 LKL--KDLTSSD-------TFKEYDPDGKGIISKKEFQKAMEGQ-KQYTQSEIDFLLSCA 3966
            L +  K L  +D        F  +D +  G I +   ++ +     Q+T  E+D L + A
Sbjct: 292  LAMFGKKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTVGDQFTDEEVDELYTEA 351

Query: 3967 EADENDMFNYVDFVDRFHEPAKD 3989
              D+   FNY++F        KD
Sbjct: 352  PIDKKGNFNYIEFTSILKHGVKD 374


>gi|51873049 hypothetical protein LOC8603 [Homo sapiens]
          Length = 1224

 Score = 38.5 bits (88), Expect = 0.16
 Identities = 32/106 (30%), Positives = 48/106 (45%), Gaps = 16/106 (15%)

Query: 4302 DLSEIIGKDEPPTLESTVQKKR---KAQAAEMKAANEAEGKV--------ESEKADMEDG 4350
            DL + I   E   + ST   KR   K +  E KA  EAE +         E  + + E+ 
Sbjct: 850  DLLQFINSSETKPVSSTRAAKRARHKQRKLEEKARLEAEARAREHLHLQEEQRRREEEED 909

Query: 4351 EKEDKDKEEEQAEYLWT-----EVTKKKKRRCGQKVEKPEAFTANF 4391
            E+E++D+ +E+ + L        V KKKK R  +   K +  T NF
Sbjct: 910  EEEEEDRFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTRNF 955


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 38.5 bits (88), Expect = 0.16
 Identities = 86/444 (19%), Positives = 169/444 (38%), Gaps = 68/444 (15%)

Query: 3216 IPTLEKLKKKAVKTVQEEEQLKADGKGDTQEAELLILDEFAVLCRDLYAFY--PMLIRYV 3273
            I  LE +       +QE+EQ K   K  +  A  ++  +   L   + A +      +  
Sbjct: 2408 ISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK 2467

Query: 3274 DNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKS 3333
            + N S+ ++  + +  QL + + E             +    V+Q+ +N L     D K 
Sbjct: 2468 EQNLSSQVECLELEKAQLLQGLDEA------------KNNYIVLQSSVNGLIQEVEDGKQ 2515

Query: 3334 KMSKA----MQVKSGGQDQER---KKTKRRGDLY-----SIQTSLIVAALKKMLPIGLNM 3381
            K+ K      ++K+  QDQE+   K ++  G+       +++   +   L++ + + L  
Sbjct: 2516 KLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQV-LQS 2574

Query: 3382 CTPGDQELISLAKSRYSHRDTD--------------------------EEVREHLRNNLH 3415
                 Q+ + + +S Y + + +                           E+ E  +    
Sbjct: 2575 KNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAE 2634

Query: 3416 LQEK--SDDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQ-RISAAVFHLEQVEQP--LRS 3470
            LQE+   +   +  +L L  + +KS +    E T+E  + + S    H +QVE+   +R 
Sbjct: 2635 LQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVRE 2694

Query: 3471 KKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQ 3530
            + A +   L +  K+             L  ++   + +  Y+      EE    +KL  
Sbjct: 2695 EIAEYQLRLHEAEKKHQALL--------LDTNKQYEVEIQTYREKLTSKEECLSSQKLEI 2746

Query: 3531 DLAKSPKVEEEEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQS 3590
            DL KS K  EE     +     L ++      N        +++        ++ KSC+ 
Sbjct: 2747 DLLKSSK--EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQ 2804

Query: 3591 GEDEEEDEDKEKTFEEKEMEKQKT 3614
             E+E+E   KE +  +   EKQKT
Sbjct: 2805 LEEEKEILQKELSQLQAAQEKQKT 2828


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 184,628,722
Number of Sequences: 37866
Number of extensions: 8605528
Number of successful extensions: 44381
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 181
Number of HSP's that attempted gapping in prelim test: 38862
Number of HSP's gapped (non-prelim): 4717
length of query: 4870
length of database: 18,247,518
effective HSP length: 124
effective length of query: 4746
effective length of database: 13,552,134
effective search space: 64318427964
effective search space used: 64318427964
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 73 (32.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.