Guide to the Human Genome
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Search of human proteins with 224809414

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
         (361 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1 [...   697   0.0  
gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1 [...   697   0.0  
gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2 [...   686   0.0  
gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3 [...   611   e-175
gi|4759198 homer 1 [Homo sapiens]                                     329   3e-90
gi|46249351 homer 2 isoform 2 [Homo sapiens]                          297   1e-80
gi|46249349 homer 2 isoform 1 [Homo sapiens]                          293   2e-79
gi|110349797 homer 2 isoform 4 [Homo sapiens]                         240   1e-63
gi|110349794 homer 2 isoform 3 [Homo sapiens]                         236   2e-62
gi|56549694 enabled homolog isoform a [Homo sapiens]                   80   2e-15
gi|39930375 enabled homolog isoform b [Homo sapiens]                   80   2e-15
gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]        59   5e-09
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom...    57   2e-08
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa...    56   6e-08
gi|126723390 ankyrin repeat domain 24 [Homo sapiens]                   55   1e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              55   1e-07
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi...    54   3e-07
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    54   3e-07
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                52   6e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         52   6e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        52   1e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        52   1e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         52   1e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         52   1e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         52   1e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         52   1e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         52   1e-06
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         52   1e-06
gi|7706687 Enah/Vasp-like [Homo sapiens]                               52   1e-06
gi|88196790 coiled-coil domain containing 88 [Homo sapiens]            52   1e-06

>gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1
           [Homo sapiens]
          Length = 361

 Score =  697 bits (1799), Expect = 0.0
 Identities = 361/361 (100%), Positives = 361/361 (100%)

Query: 1   MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
           MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1   MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60

Query: 61  NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
           NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS
Sbjct: 61  NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120

Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
           QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180

Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
           GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240

Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
           EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL
Sbjct: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300

Query: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
           ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360

Query: 361 P 361
           P
Sbjct: 361 P 361


>gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1
           [Homo sapiens]
          Length = 361

 Score =  697 bits (1799), Expect = 0.0
 Identities = 361/361 (100%), Positives = 361/361 (100%)

Query: 1   MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
           MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1   MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60

Query: 61  NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
           NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS
Sbjct: 61  NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120

Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
           QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180

Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
           GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240

Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
           EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL
Sbjct: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300

Query: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
           ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360

Query: 361 P 361
           P
Sbjct: 361 P 361


>gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2
           [Homo sapiens]
          Length = 358

 Score =  686 bits (1770), Expect = 0.0
 Identities = 358/361 (99%), Positives = 358/361 (99%), Gaps = 3/361 (0%)

Query: 1   MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
           MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1   MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60

Query: 61  NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
           NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS
Sbjct: 61  NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120

Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
           QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180

Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
           GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240

Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
           EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQ  
Sbjct: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQ-- 298

Query: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
            TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 299 -TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 357

Query: 361 P 361
           P
Sbjct: 358 P 358


>gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3
           [Homo sapiens]
          Length = 325

 Score =  611 bits (1575), Expect = e-175
 Identities = 325/361 (90%), Positives = 325/361 (90%), Gaps = 36/361 (9%)

Query: 1   MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
           MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1   MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60

Query: 61  NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
           NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQ                   
Sbjct: 61  NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQ------------------- 101

Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
                            VPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 102 -----------------VPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 144

Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
           GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 145 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 204

Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
           EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL
Sbjct: 205 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 264

Query: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
           ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 265 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 324

Query: 361 P 361
           P
Sbjct: 325 P 325


>gi|4759198 homer 1 [Homo sapiens]
          Length = 354

 Score =  329 bits (843), Expect = 3e-90
 Identities = 185/359 (51%), Positives = 240/359 (66%), Gaps = 11/359 (3%)

Query: 6   EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
           EQPIFSTRAHVFQIDP TK+NW+P  KHA+TVSYFYD+TRNVYRIIS+ G+KAIINST+T
Sbjct: 3   EQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTIT 62

Query: 66  PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
           PNMTFTKTSQKFGQWADSRANTVYGLGF+SE HL++FAEKFQE KEAARLA+EKSQ+  E
Sbjct: 63  PNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKME 122

Query: 126 LTSPALGLASHQVPPSPLV--SANGPGEEKL--FRSQSADAPGPTERERLKKMLSEGSVG 181
           LTS     ++     SPL   S NG  +E+       S     PT+        S  S  
Sbjct: 123 LTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQN---ALPFSHSSAI 179

Query: 182 EVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE 241
              WEAE   L+ +N KL  AL E+ A   QW+QQL A + EAERL +RV ELE  ++  
Sbjct: 180 SKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQA 239

Query: 242 VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLE 301
                 K  L   Q++++LE  ++ K++EI+ LK +    RE  E  +R+   QK+Q++E
Sbjct: 240 NAVHTHKTEL--NQTIQELEETLKLKEEEIERLKQEIDNARELQE--QRDSLTQKLQEVE 295

Query: 302 TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
            RN +LE QL  +E+ LE+++ E+E  R  +    ++LD  +FEL+ELR+ LA+L E +
Sbjct: 296 IRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS 354


>gi|46249351 homer 2 isoform 2 [Homo sapiens]
          Length = 354

 Score =  297 bits (760), Expect = 1e-80
 Identities = 161/352 (45%), Positives = 236/352 (67%), Gaps = 5/352 (1%)

Query: 6   EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
           EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3   EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62

Query: 66  PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
           PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+  E
Sbjct: 63  PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122

Query: 126 LTSPALGLASHQVPPSPLVSA-NGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQ 184
            +S     +  + P S   S+ NG  +EK   +  A+    +E ++LK  L++ +    +
Sbjct: 123 TSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKK 182

Query: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
           WE E   L++SN +L  AL+E+ A+  QW++Q    R E +RLR ++ ELE Q  SE+  
Sbjct: 183 WEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINR 241

Query: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRN 304
             EK      + +E+LEA ++ K+ E++ L+ Q+    + +  +E E   +K++  E  N
Sbjct: 242 EKEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM--SECEYVSEKLEAAERDN 298

Query: 305 AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
             LE ++R+++  +EE++  +   + E+    ++LD  + +L + R GL++L
Sbjct: 299 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 350


>gi|46249349 homer 2 isoform 1 [Homo sapiens]
          Length = 343

 Score =  293 bits (749), Expect = 2e-79
 Identities = 161/351 (45%), Positives = 234/351 (66%), Gaps = 14/351 (3%)

Query: 6   EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
           EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3   EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62

Query: 66  PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
           PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+  E
Sbjct: 63  PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122

Query: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
            +S      +H    S   S NG  +EK   +  A+    +E ++LK  L++ +    +W
Sbjct: 123 TSS------NH----SQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKW 172

Query: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
           E E   L++SN +L  AL+E+ A+  QW++Q    R E +RLR ++ ELE Q  SE+   
Sbjct: 173 EIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINRE 231

Query: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNA 305
            EK      + +E+LEA ++ K+ E++ L+ Q+    + +  +E E   +K++  E  N 
Sbjct: 232 KEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM--SECEYVSEKLEAAERDNQ 288

Query: 306 ELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
            LE ++R+++  +EE++  +   + E+    ++LD  + +L + R GL++L
Sbjct: 289 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 339


>gi|110349797 homer 2 isoform 4 [Homo sapiens]
          Length = 299

 Score =  240 bits (613), Expect = 1e-63
 Identities = 145/352 (41%), Positives = 206/352 (58%), Gaps = 60/352 (17%)

Query: 6   EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
           EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3   EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62

Query: 66  PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
           PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+  E
Sbjct: 63  PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122

Query: 126 LTSPALGLASHQVPPSPLVSA-NGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQ 184
            +S     +  + P S   S+ NG  +EK      A   GP                   
Sbjct: 123 TSSNHSQESGRETPSSTQASSVNGTDDEK------ASHAGPANTH--------------- 161

Query: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
                  L+  N+KL  AL +   +AA  + ++  ++ +  +L++R+ ELEA+   + T 
Sbjct: 162 -------LKSENDKLKIALTQ---SAANVKNEINREKEKNTQLKRRIEELEAELREKETE 211

Query: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRN 304
             +                ++ + + I  L S+     E LEAAER+            N
Sbjct: 212 LKD----------------LRKQSEIIPQLMSECEYVSEKLEAAERD------------N 243

Query: 305 AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
             LE ++R+++  +EE++  +   + E+    ++LD  + +L + R GL++L
Sbjct: 244 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 295


>gi|110349794 homer 2 isoform 3 [Homo sapiens]
          Length = 288

 Score =  236 bits (602), Expect = 2e-62
 Identities = 145/351 (41%), Positives = 204/351 (58%), Gaps = 69/351 (19%)

Query: 6   EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
           EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3   EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62

Query: 66  PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
           PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+  E
Sbjct: 63  PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122

Query: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
            +S      +H    S   S NG  +EK      A   GP                    
Sbjct: 123 TSS------NH----SQASSVNGTDDEK------ASHAGPANTH---------------- 150

Query: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
                 L+  N+KL  AL +   +AA  + ++  ++ +  +L++R+ ELEA+   + T  
Sbjct: 151 ------LKSENDKLKIALTQ---SAANVKNEINREKEKNTQLKRRIEELEAELREKETEL 201

Query: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNA 305
            +                ++ + + I  L S+     E LEAAER+            N 
Sbjct: 202 KD----------------LRKQSEIIPQLMSECEYVSEKLEAAERD------------NQ 233

Query: 306 ELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
            LE ++R+++  +EE++  +   + E+    ++LD  + +L + R GL++L
Sbjct: 234 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 284


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 88/316 (27%), Positives = 126/316 (39%), Gaps = 64/316 (20%)

Query: 6   EQPIFSTRAHVFQIDPATKRNWIPAGKHA--LTVSYFYDATRNVYRIIS--IGGAKAIIN 61
           EQ I   RA V   D A K+ W+PAG       V  ++    N +R++   I   + +IN
Sbjct: 3   EQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVIN 61

Query: 62  STVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQ 121
             +   + + + +Q F QW D+R   VYGL F S++    FA       E        SQ
Sbjct: 62  CAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEVL-----NSQ 114

Query: 122 DGGELTSPALGLASHQVPPSPLVSANGPGEEKL----FRSQSADAPGPTERERLKKMLSE 177
           +    T P L   + Q+P       NGP +E+L     + Q        ERERL+     
Sbjct: 115 E----TGPTLPRQNSQLPAQ---VQNGPSQEELEIQRRQLQEQQRQKELERERLE----- 162

Query: 178 GSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQ 237
                                     RE        R++LE +R E ERL Q   E E Q
Sbjct: 163 --------------------------RERMERERLERERLERERLERERLEQEQLERERQ 196

Query: 238 AASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKV 297
                     +E L + + LE+ E L    D+E Q  +      RE LE  ERE  +++ 
Sbjct: 197 ERERQERLERQERLERQERLERQERL----DRERQERQE-----RERLERLERERQERER 247

Query: 298 QD-LETRNAELEHQLR 312
           Q+ LE    E E + R
Sbjct: 248 QEQLEREQLEWERERR 263



 Score = 30.8 bits (68), Expect = 2.0
 Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 3/58 (5%)

Query: 277 QTGGPREALEAAERE-ETQQKVQDLETRNAELEHQLRA-MERS-LEEARAERERARAE 331
           Q G  +E LE   R+ + QQ+ ++LE    E E   R  +ER  LE  R ERER   E
Sbjct: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQE 189



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 34/129 (26%), Positives = 54/129 (41%), Gaps = 22/129 (17%)

Query: 201 GALREANAAAAQWRQQLEAQRAE--AERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE 258
           G+  +AN  A+     LE   ++     L ++ ++L AQ  +             G S E
Sbjct: 92  GSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQN-------------GPSQE 138

Query: 259 QLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSL 318
           +LE     + +++Q  + Q    RE LE    E  + + + LE    E E   R  +  L
Sbjct: 139 ELEI----QRRQLQEQQRQKELERERLERERMERERLERERLERERLERE---RLEQEQL 191

Query: 319 EEARAERER 327
           E  R ERER
Sbjct: 192 ERERQERER 200


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 88/316 (27%), Positives = 126/316 (39%), Gaps = 64/316 (20%)

Query: 6   EQPIFSTRAHVFQIDPATKRNWIPAGKHA--LTVSYFYDATRNVYRIIS--IGGAKAIIN 61
           EQ I   RA V   D A K+ W+PAG       V  ++    N +R++   I   + +IN
Sbjct: 3   EQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVIN 61

Query: 62  STVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQ 121
             +   + + + +Q F QW D+R   VYGL F S++    FA       E        SQ
Sbjct: 62  CAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEVL-----NSQ 114

Query: 122 DGGELTSPALGLASHQVPPSPLVSANGPGEEKL----FRSQSADAPGPTERERLKKMLSE 177
           +    T P L   + Q+P       NGP +E+L     + Q        ERERL+     
Sbjct: 115 E----TGPTLPRQNSQLPAQ---VQNGPSQEELEIQRRQLQEQQRQKELERERLE----- 162

Query: 178 GSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQ 237
                                     RE        R++LE +R E ERL Q   E E Q
Sbjct: 163 --------------------------RERMERERLERERLERERLERERLEQEQLERERQ 196

Query: 238 AASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKV 297
                     +E L + + LE+ E L    D+E Q  +      RE LE  ERE  +++ 
Sbjct: 197 ERERQERLERQERLERQERLERQERL----DRERQERQE-----RERLERLERERQERER 247

Query: 298 QD-LETRNAELEHQLR 312
           Q+ LE    E E + R
Sbjct: 248 QEQLEREQLEWERERR 263



 Score = 30.8 bits (68), Expect = 2.0
 Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 3/58 (5%)

Query: 277 QTGGPREALEAAERE-ETQQKVQDLETRNAELEHQLRA-MERS-LEEARAERERARAE 331
           Q G  +E LE   R+ + QQ+ ++LE    E E   R  +ER  LE  R ERER   E
Sbjct: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQE 189



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 34/129 (26%), Positives = 54/129 (41%), Gaps = 22/129 (17%)

Query: 201 GALREANAAAAQWRQQLEAQRAE--AERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE 258
           G+  +AN  A+     LE   ++     L ++ ++L AQ  +             G S E
Sbjct: 92  GSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQN-------------GPSQE 138

Query: 259 QLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSL 318
           +LE     + +++Q  + Q    RE LE    E  + + + LE    E E   R  +  L
Sbjct: 139 ELEI----QRRQLQEQQRQKELERERLERERMERERLERERLERERLERE---RLEQEQL 191

Query: 319 EEARAERER 327
           E  R ERER
Sbjct: 192 ERERQERER 200


>gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]
          Length = 380

 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 50/168 (29%), Positives = 74/168 (44%), Gaps = 26/168 (15%)

Query: 6   EQPIFSTRAHVFQIDPATKRNWIPAGKHALT---VSYFYDATRNVYRIISIG---GAKAI 59
           E  I S+RA V   D   KR W+PAG        V  +++ T N +R++        + +
Sbjct: 3   ETVICSSRATVMLYDDGNKR-WLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVV 61

Query: 60  INSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREK 119
           IN  +   + + + +  F QW D+R   V+GL F S++   QFA       EA       
Sbjct: 62  INCAIVRGVKYNQATPNFHQWRDAR--QVWGLNFGSKEDAAQFAAGMASALEAL------ 113

Query: 120 SQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
            + GG    PA  L +  VP       NGP  E++   Q    PGP+E
Sbjct: 114 -EGGGPPPPPA--LPTWSVP-------NGPSPEEV-EQQKRQQPGPSE 150


>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
           sapiens]
          Length = 1551

 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 69/266 (25%), Positives = 99/266 (37%), Gaps = 24/266 (9%)

Query: 96  EQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLF 155
           EQ   + + K QE   A    RE  Q   E+ +    L       + L   +GP      
Sbjct: 423 EQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAG--- 479

Query: 156 RSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ 215
            S   D+    E +RL + L+EG  G    E E    Q    +L   L+EA    A    
Sbjct: 480 -SPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATAS 538

Query: 216 QLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
           Q  A  ++ E  R    ELEAQ +S      + +G  + +  E  +A       E   + 
Sbjct: 539 QTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMG 598

Query: 276 SQTGGPREAL----EAAEREETQQ-----------KVQDLETRNAELEHQLRAMERSL-- 318
              GGP+EA      AA RE+ +Q            +  L+  N  L  +   +E  L  
Sbjct: 599 PPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQ 658

Query: 319 ---EEARAERERARAEVGRAAQLLDV 341
               + R E ER   E    AQL D+
Sbjct: 659 EQESKQRLEGERRETESNWEAQLADI 684



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 61/215 (28%), Positives = 95/215 (44%), Gaps = 28/215 (13%)

Query: 148 GPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREAN 207
           GP E +L +  +A       RE+L++  S    G+   E     LQ+ N +L+       
Sbjct: 603 GPQEAQLRKEVAA------LREQLEQAHSHRPSGK---EEALCQLQEENRRLSREQERLE 653

Query: 208 AAAAQWRQQLEAQRAEAERLRQRVAELEAQAA---SEVTPTGEKEGLGQGQSLEQLEALV 264
           A  AQ  +Q   QR E ER R+  +  EAQ A   S V       G  Q  + +  E L 
Sbjct: 654 AELAQ--EQESKQRLEGER-RETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELE 710

Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAME------RSL 318
             ++   QTL ++   P +    A R +  +    LE ++A LE ++RA +        +
Sbjct: 711 SLRNVGTQTLPAR---PLDHQWKARRLQKMEASARLELQSA-LEAEIRAKQGLQERLTQV 766

Query: 319 EEARAERERARAEVGRAAQLLDVSLFELSELREGL 353
           +EA+ + ER   E  + +Q L     EL+ LRE L
Sbjct: 767 QEAQLQAERRLQEAEKQSQALQQ---ELAMLREEL 798


>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
           sapiens]
          Length = 631

 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 45/212 (21%)

Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNK----------LA 200
           EE+L R Q        + E+ +K+     + E Q +AE    ++   +          L 
Sbjct: 344 EEELLRLQQL------QEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397

Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS-------EVTPTGEKEGLGQ 253
           G LREA  A A  + ++E +  EA R RQR+ ELE            EV    ++E +  
Sbjct: 398 GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRI 457

Query: 254 GQSL------EQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAEL 307
            Q+       E+L+ L+Q K+++ + +                E  QQ+ ++L+   A+ 
Sbjct: 458 AQTRLLEEEEEKLKQLMQLKEEQERYI----------------ERAQQEKEELQQEMAQQ 501

Query: 308 EHQLRAMERSLEEARAERERARAEVGRAAQLL 339
              L+  ++ LEE R  R+RA  +V  A + L
Sbjct: 502 SRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533


>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
          Length = 1146

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 71/233 (30%), Positives = 102/233 (43%), Gaps = 29/233 (12%)

Query: 144 VSANG---PGEEKLFRSQSADAPGPTERERLKKMLSEGSVG-EVQWEAEFFALQDSNNKL 199
           VSA G   PG E       A  PG +    L    +E S   +V+ E     L+++   L
Sbjct: 687 VSATGVENPGVE-------ATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEA---L 736

Query: 200 AGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQ 259
               REA A       + EA  AEA RLR+RV E E   AS     G  +      +LEQ
Sbjct: 737 RQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGAS---GGGGGDTTQLRAALEQ 793

Query: 260 LEALVQTKDQEIQTLKSQTGGPREALEA---AEREETQQKVQDLETRNAELE--HQLRAM 314
               ++ +D  ++ L++ +    EA  +   AE E    + +  +   A LE   +L  +
Sbjct: 794 AREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVL 853

Query: 315 ERSLEEARAERERAR---AEVGRAAQLLDVSLFEL----SELREGLARLAEAA 360
              L  ARA  E+ R   AE+GRA    +  + EL     E R+GLA L EA+
Sbjct: 854 REQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREAS 906



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 59/239 (24%), Positives = 93/239 (38%), Gaps = 26/239 (10%)

Query: 76   KFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLAS 135
            + G+  D+    V  L  A E+     AE  +E  EA R +   + +   L   AL L  
Sbjct: 873  ELGRARDAAEARVAELPAACEEARQGLAE-LREASEALRQSVVPASEHRRLQEEALELRG 931

Query: 136  HQVPPSPLVSANGPGEEKL---FRSQSADAPGPTERERLKKMLS------EGSVGEV--- 183
                    V A G    +L      +   +   +E ER+   L       EG + E+   
Sbjct: 932  RAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRR 991

Query: 184  --QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE 241
              +  AE F +Q     +      A A  A   QQL   R EAER RQ  A+  AQ A +
Sbjct: 992  HEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQ--AQSRAQEALD 1049

Query: 242  VTPTGE-------KEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREET 293
                 +       KE     ++L++  A + T   E++ L+ Q    ++ L+ A R+ +
Sbjct: 1050 KAKEKDKKITELSKEVFNLKEALKEQPAALAT--PEVEALRDQVKDLQQQLQEAARDHS 1106


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 65/275 (23%), Positives = 104/275 (37%), Gaps = 20/275 (7%)

Query: 74   SQKFGQWADSRANTVYGLGFASEQH------LTQFAEKFQEVKEAARLAREKSQDGGELT 127
            SQ+  +  D +     G   A E+        T    +  E ++      E+ + GG+ +
Sbjct: 1749 SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS 1808

Query: 128  SPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV----GEV 183
                 L                G E +  +  A+     E E ++   +EG      GE 
Sbjct: 1809 GHEDNLQGEAAAGGDQDPGQSDGAEGI-EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEA 1867

Query: 184  QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVT 243
            Q E+E     ++  +      +     A+W  Q E++ AEA       AE EAQ  +E  
Sbjct: 1868 QPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPE-----AEKEAQPETESV 1922

Query: 244  PTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAE-REETQQKVQDLET 302
               E EG  + +S E  EA  Q  ++  Q  + QT    E +E+ E  EE Q + +D+E 
Sbjct: 1923 EALETEGEDEPES-EGAEA--QEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEA 1979

Query: 303  RNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 337
               E+E Q    E   E    E   A  E+  A +
Sbjct: 1980 LEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEE 2014



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 47/198 (23%), Positives = 83/198 (41%), Gaps = 14/198 (7%)

Query: 151  EEKLFRSQSADAPGPTERERLK----KMLSEGSVGEVQWEAEFFALQDSNNKLAGALREA 206
            E ++  SQ A+     E E ++    ++ ++ + GE Q E+E     ++  ++  A  EA
Sbjct: 1957 ESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEA 2016

Query: 207  NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE----VTPTGEKEGL---GQGQSLEQ 259
               +     Q +++  EA+ +     + E  A  E      P  E+E     G+ Q  E 
Sbjct: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEG 2076

Query: 260  LEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
             EA  +++D + Q  + +     E +EA E E   QK + +E    E E + +     +E
Sbjct: 2077 -EAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA--PETEGEAQPESEGIE 2133

Query: 320  EARAERERARAEVGRAAQ 337
               AE E      G  AQ
Sbjct: 2134 APEAEGEAQPESEGVEAQ 2151



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 68/242 (28%), Positives = 99/242 (40%), Gaps = 30/242 (12%)

Query: 108  EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
            E++EA   A+ +S DG E    + G  + +V      +      E    S   +AP   E
Sbjct: 2008 EMQEAEEEAQPES-DGVEAQPKSEGEEAQEVEGETQKTEGDAQPE----SDGVEAPEAEE 2062

Query: 168  RERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAE---- 223
                    ++ + GEVQ EAE  A  +S +  A   +EA   A    + +EA  AE    
Sbjct: 2063 E-------AQEAEGEVQ-EAEGEAHPESEDVDA---QEAEGEAQPESEGVEAPEAEGEAQ 2111

Query: 224  -AERLRQRVAELEAQAASEVTPTGEKEGLGQGQSL------EQLEALVQTKDQEIQTLKS 276
             AE +     E EAQ  SE     E EG  Q +S        + EA  +++  E Q  + 
Sbjct: 2112 KAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEE 2171

Query: 277  QTGGPREALEAAERE-ETQQKVQDLETRNAELEHQ--LRAMERSLEEARAERERARAEVG 333
            +     E +EA E E E Q + + +E   AE E Q  L  +E    E  A+ E    E  
Sbjct: 2172 EAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETP 2231

Query: 334  RA 335
             A
Sbjct: 2232 EA 2233



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 35/117 (29%), Positives = 49/117 (41%), Gaps = 13/117 (11%)

Query: 151  EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
            E +   +Q A+     E E ++   +EG   E Q E+E     ++  +    L    A  
Sbjct: 2160 ESEGIEAQEAEEEAQPELEGVEAPEAEG---EAQPESEGIEAPEAEGEAQPELEGVEAPE 2216

Query: 211  AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEG-----LGQGQSLEQLEA 262
            A+   Q E +  E        AE EAQ  SE    GEK+G     LG GQS E  E+
Sbjct: 2217 AEEEAQPEPEGVETPE-----AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASES 2268



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 33/123 (26%), Positives = 51/123 (41%), Gaps = 5/123 (4%)

Query: 234  LEAQAASEVTPTGEKEGLGQGQ----SLEQLEALVQTKDQEIQTLKSQTGGPREALEAAE 289
            L A+A +  T   E E   + Q    +LEQL      ++ +++  K  T G     EA +
Sbjct: 1262 LNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQ 1321

Query: 290  REETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSEL 349
             EET+ + + L+    +LE          +E  A+ E      G   Q   V L E+ E 
Sbjct: 1322 LEETKTE-EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG 1380

Query: 350  REG 352
             EG
Sbjct: 1381 PEG 1383



 Score = 29.6 bits (65), Expect = 4.4
 Identities = 51/212 (24%), Positives = 79/212 (37%), Gaps = 35/212 (16%)

Query: 107  QEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPT 166
            QE+ EA+    + SQ+   +     G AS    P P      P E     S++   P  +
Sbjct: 1408 QELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSET--DPSAS 1465

Query: 167  ERERLKKMLS--EGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ----WRQQL--E 218
            ER+   ++    E   G      E    Q +      +   A +AA      W   L  +
Sbjct: 1466 ERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKK 1525

Query: 219  AQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQ---------TKDQ 269
             ++A    L   VAEL A           + GL     L+Q+ A +Q         +  +
Sbjct: 1526 TEKAFLAHLASAVAELRA-----------RWGLQDNDLLDQMAAELQQDVAQRLQDSTKR 1574

Query: 270  EIQTLKSQTG-----GPREALEAAEREETQQK 296
            E+Q L+ + G      PREAL      +TQQ+
Sbjct: 1575 ELQKLQGRAGRMVLEPPREALTGELLLQTQQR 1606


>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
           sapiens]
          Length = 1478

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 52/193 (26%), Positives = 91/193 (47%), Gaps = 10/193 (5%)

Query: 172 KKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRV 231
           +  L EG +  +Q  A++ ALQ   + + G+L    A  A  R   +   A    +R+  
Sbjct: 631 RNQLLEGKLQALQ--ADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAK 688

Query: 232 AELEAQAASEVTPTGEKEGLGQ--GQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAE 289
             ++AQ A +      KEG  Q   + +EQ + L + + +E++ L+SQ     + +E   
Sbjct: 689 EAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLT 748

Query: 290 REETQQKV---QDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFEL 346
            E+ QQ V    D E R  EL  QL   +  LE  + E +R +A+V      +  +L + 
Sbjct: 749 AEKGQQGVGPPTDNEAR--ELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQ 806

Query: 347 SELREGLARLAEA 359
            +++  L+ +AEA
Sbjct: 807 DKVQSQLS-MAEA 818



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 37/142 (26%), Positives = 64/142 (45%), Gaps = 15/142 (10%)

Query: 204 REANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEAL 263
           RE  A  A  + QLE  + E +RL+ +V +L+A+  + +    + +       L   EA+
Sbjct: 765 RELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQS-----QLSMAEAV 819

Query: 264 VQTKDQEIQTLKSQTGG-----PREALEAAERE-----ETQQKVQDLETRNAELEHQLRA 313
           ++     +Q LK Q         +E L+ +ERE     E   + Q  E     L+ +L  
Sbjct: 820 LREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQ 879

Query: 314 MERSLEEARAERERARAEVGRA 335
            + S EEA+ E    + ++ RA
Sbjct: 880 AKCSSEEAQLEHAELQEQLHRA 901



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 36/167 (21%), Positives = 75/167 (44%), Gaps = 13/167 (7%)

Query: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
           W A      D+ +   G      + AAQ  Q+L  +    ER R +V E+  Q ++++  
Sbjct: 371 WLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQL-- 428

Query: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRN 304
              ++ + + Q  E   A ++   +E+  L+ +  G     +  E ++  +++Q+L    
Sbjct: 429 ---EQLVKELQLKEDARASLERLVKEMAPLQEELSG-----KGQEADQLWRRLQELLAHT 480

Query: 305 AELEHQLRAMERSLEEARAERERARAEV---GRAAQLLDVSLFELSE 348
           +  E +L  + R  ++ + E+E    EV    R  Q L+  L ++S+
Sbjct: 481 SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQ 527



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 46/194 (23%), Positives = 85/194 (43%), Gaps = 27/194 (13%)

Query: 158 QSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQL 217
           Q AD    T + R + + S+ +    +   +  AL+    K+    R+ +A   Q  ++L
Sbjct: 377 QKADTASDT-KGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKEL 435

Query: 218 EAQ---RAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQL-----EALVQTKD- 268
           + +   RA  ERL + +A L+ + +            G+GQ  +QL     E L  T   
Sbjct: 436 QLKEDARASLERLVKEMAPLQEELS------------GKGQEADQLWRRLQELLAHTSSW 483

Query: 269 ----QEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAE 324
                E++  K Q    +E LE   R  T+Q +Q LET+ A++   +  +E   ++   +
Sbjct: 484 EEELAELRREKKQQQEEKELLEQEVRSLTRQ-LQFLETQLAQVSQHVSDLEEQKKQLIQD 542

Query: 325 RERARAEVGRAAQL 338
           ++    +VG   +L
Sbjct: 543 KDHLSQQVGMLERL 556



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 42/194 (21%), Positives = 78/194 (40%), Gaps = 19/194 (9%)

Query: 184  QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERL----------RQRVAE 233
            Q E E  ALQ+  ++   +  EA    A+ ++QL     +   L          ++RV E
Sbjct: 865  QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEE 924

Query: 234  LEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLK-------SQTGGPREALE 286
              A A  E+    E     +     Q+  L Q K+   + LK       S  G   +  +
Sbjct: 925  ALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQ 984

Query: 287  AAEREETQQKV--QDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLF 344
            A +R ++ Q+   Q+L T   +L  ++   +  L+ A  E +  R ++    + L  +  
Sbjct: 985  AEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEE 1044

Query: 345  ELSELREGLARLAE 358
             + +L+   A + E
Sbjct: 1045 AVEKLKATQADMGE 1058


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 55/235 (23%), Positives = 104/235 (44%), Gaps = 16/235 (6%)

Query: 131  LGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFF 190
            L   S +V    L+ A    + K  ++++ +     E ER  +   E    E   E E  
Sbjct: 1136 LSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELE-- 1193

Query: 191  ALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEG 250
                   +L+  L EA  A+A  R+    + AE  RLR+ + E   +  + V     K+ 
Sbjct: 1194 -------ELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQA 1246

Query: 251  LGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKV------QDLETRN 304
             G  +  EQ+++L + + Q+++  KS+     + L A     T+ K       +  E + 
Sbjct: 1247 EGAAELGEQVDSLQRVR-QKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305

Query: 305  AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
            +E + ++  ++R L +A  +R R + E G  ++LL+     +S+L  G A  A++
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQS 1360



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 66/267 (24%), Positives = 109/267 (40%), Gaps = 35/267 (13%)

Query: 101  QFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSA 160
            Q +E   +V+E  R   + S   G L + +  L+        L+S    G+    +S   
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEE 1363

Query: 161  DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ-----DSNNKLAGALREANAAAAQWRQ 215
                  E  + K  L+  +V  ++ + +    Q     ++  +L   L +ANA  AQWR 
Sbjct: 1364 LRRQLEEESKAKSALAH-AVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRS 1422

Query: 216  QLEA---QRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQ 272
            + EA   QR E     ++   L  Q A E    G +    +  SLE+ +  +QT+ +++ 
Sbjct: 1423 KYEADAIQRTEELEEAKKKLALRLQEAEE----GVEAANAKCSSLEKAKLRLQTESEDV- 1477

Query: 273  TLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEV 332
            TL+ +      A  AA                A L+ + R +ER+LEE R + E  + E+
Sbjct: 1478 TLELE-----RATSAA----------------AALDKKQRHLERALEERRRQEEEMQREL 1516

Query: 333  GRAAQLLDVSLFELSELREGLARLAEA 359
              A +       EL  LR G     EA
Sbjct: 1517 EAAQRESRGLGTELFRLRHGHEEALEA 1543



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 49/199 (24%), Positives = 85/199 (42%), Gaps = 25/199 (12%)

Query: 150  GEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAA 209
            GE+   ++   +A G  E E  K +  +  + +V+ E +   L + + + A   R    A
Sbjct: 1584 GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR-KLAEKDEECANLRRNHQRA 1642

Query: 210  AAQWRQQLEAQ---RAEAERLRQRVA----ELEAQAASEVTPTGEKEGLGQGQSLEQLEA 262
                +  L+A+   R EA RL++++     +LE Q             LG   + +  EA
Sbjct: 1643 VESLQASLDAETRARNEALRLKKKMEGDLNDLELQ-------------LGHA-TRQATEA 1688

Query: 263  LVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEAR 322
               T+  + Q  + Q G   E   AAE  E   + Q LE R + L  +L  +  +LE+  
Sbjct: 1689 QAATRLMQAQLKEEQAGRDEEQRLAAELHE---QAQALERRASLLAAELEELRAALEQGE 1745

Query: 323  AERERARAEVGRAAQLLDV 341
              R  A  E+  A + L++
Sbjct: 1746 RSRRLAEQELLEATERLNL 1764



 Score = 38.1 bits (87), Expect = 0.012
 Identities = 43/161 (26%), Positives = 70/161 (43%), Gaps = 15/161 (9%)

Query: 204  REANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEAL 263
            R  +AAAA  ++Q   +RA  ER RQ   E E Q   E     ++E  G G  L +L   
Sbjct: 1483 RATSAAAALDKKQRHLERALEERRRQ---EEEMQRELEAA---QRESRGLGTELFRLRHG 1536

Query: 264  VQTKDQEIQTLKSQTGGPREALEAAEREETQ--QKVQDLETRNAELEHQLRAMERSLEEA 321
             +   + ++TLK +    +E +     + +   + +Q+LE     LE +   ++ +LEEA
Sbjct: 1537 HEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEA 1596

Query: 322  RAERE-------RARAEVGRAAQLLDVSLFELSELREGLAR 355
                E       R + E+ +    +D  L E  E    L R
Sbjct: 1597 EGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRR 1637



 Score = 36.2 bits (82), Expect = 0.047
 Identities = 57/199 (28%), Positives = 83/199 (41%), Gaps = 29/199 (14%)

Query: 167  ERERLKKMLSEGSVGEVQWEAEFF--ALQDSNNKLAGALREANAAAAQWRQQLEAQRAEA 224
            E E+ KK L EG   E+Q   E    AL+    K      E +   A+  ++L  +  E 
Sbjct: 1574 ELEKTKKAL-EGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEEC 1632

Query: 225  ERLR---QRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG-G 280
              LR   QR  E   QA+ +       E L   + +E           ++  L+ Q G  
Sbjct: 1633 ANLRRNHQRAVE-SLQASLDAETRARNEALRLKKKMEG----------DLNDLELQLGHA 1681

Query: 281  PREALEA--------AEREETQQKVQDLETRNAELEHQLRAMER--SLEEARAERERARA 330
             R+A EA        A+ +E Q    + +   AEL  Q +A+ER  SL  A  E  RA  
Sbjct: 1682 TRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAAL 1741

Query: 331  EVG-RAAQLLDVSLFELSE 348
            E G R+ +L +  L E +E
Sbjct: 1742 EQGERSRRLAEQELLEATE 1760


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 85/321 (26%), Positives = 122/321 (38%), Gaps = 67/321 (20%)

Query: 84  RANTVYGLGFASEQ--HLTQFAEKFQEVKEAARLAREKS--------QDGG----ELTSP 129
           ++N  + L  A +Q   L Q  EK Q  +E  R  R++         QDG     EL   
Sbjct: 605 KSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERS 664

Query: 130 ALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWE--- 186
              L   +   S L        E L R+         E+  + + L++   G V+ E   
Sbjct: 665 HRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSM 724

Query: 187 ----AEFFALQDSNNKLAG----------------ALREANAAAAQWRQQLEAQRA---- 222
               AE  +LQDS +KL+                 A  E   +A Q RQ+   Q A    
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR 784

Query: 223 -EAERLRQ----------------RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQ 265
            E ERL +                RVAE   +A  +  PT   E     + L QL   + 
Sbjct: 785 EEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS 844

Query: 266 TKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAER 325
            ++QE++  + +     EALE A RE+     + L   +A L  QL A ER       E 
Sbjct: 845 GREQELEQARREAQRQVEALERAAREK-----EALAKEHAGLAVQLVAAEREGRTLSEEA 899

Query: 326 ERARAEVGRAAQLLDVSLFEL 346
            R R E     + L+ SLFE+
Sbjct: 900 TRLRLE----KEALEGSLFEV 916



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 55/197 (27%), Positives = 87/197 (44%), Gaps = 14/197 (7%)

Query: 164  GPTERERLKKMLSEGSVGEVQWEAEFFAL----QDSNNKLAGALREANAAAAQWRQQLEA 219
            G  ERE L++   E      + E+E  +L    +D   KLA  L EA  A  +   +L  
Sbjct: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLA-LLEEARTAVGKEAGELRT 1266

Query: 220  QRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG 279
               E ER R   A  E Q         + E    G+ L +L+  +   ++  +  + +T 
Sbjct: 1267 GLQEVERSRLE-ARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325

Query: 280  GPREALEAAER--EETQQKVQDLETRNAELEHQLRAMER----SLEEARAERERARAEVG 333
            G R+ L   E   E  +Q++Q  + +  E E + R  ER    SLEEAR   E+ + +  
Sbjct: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARG-TEKQQLDHA 1384

Query: 334  RAAQL-LDVSLFELSEL 349
            R  +L L+ +  E +EL
Sbjct: 1385 RGLELKLEAARAEAAEL 1401



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 74/267 (27%), Positives = 108/267 (40%), Gaps = 47/267 (17%)

Query: 96   EQHLTQFAEKFQEVKEAA-RLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL 154
            EQ L Q   + Q   EA  R AREK      L     GLA        LV+A   G    
Sbjct: 847  EQELEQARREAQRQVEALERAAREKEA----LAKEHAGLAVQ------LVAAEREG---- 892

Query: 155  FRSQSADAPGPTERERLKKMLSEGSVGEVQWE-AEFFALQDSNNKLAGALREANAAAAQW 213
             R+ S +A     R RL+K   EGS+ EVQ + A+  A ++       AL  A       
Sbjct: 893  -RTLSEEAT----RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK------ 941

Query: 214  RQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQT 273
                E    E   LRQ++   + +A+       +KE + Q         LVQ + +   +
Sbjct: 942  ----ETLTGELAGLRQQIIATQEKASL------DKELMAQ--------KLVQAEREAQAS 983

Query: 274  LKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQL-RAMERSLEEARAERERARAEV 332
            L+ Q     E L+  +RE+ +   ++LE   A+L+ QL R  E  L    AE+E    E+
Sbjct: 984  LREQRAAHEEDLQRLQREK-EAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEI 1042

Query: 333  GRAAQLLDVSLFELSELREGLARLAEA 359
                Q  D  L      ++    L E+
Sbjct: 1043 AALQQERDEGLLLAESEKQQALSLKES 1069



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 56/257 (21%), Positives = 106/257 (41%), Gaps = 15/257 (5%)

Query: 90   GLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVP-PSPLVSANG 148
            GL  ++ +   Q  E      E  R A E +Q GG  ++   GL   + P P+P      
Sbjct: 1402 GLRLSAAEGRAQGLEAELARVEVQRRAAE-AQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460

Query: 149  PGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNK-LAGALREAN 207
            P  +            P+  E      S GS       A   A  D + + + GALRE  
Sbjct: 1461 PARDAPAEGSGEGLNSPSTLE-----CSPGSQPPSPGPATSPASPDLDPEAVRGALREFL 1515

Query: 208  AAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTK 267
                  +++ +  R +   L +++AE+EA+  S  +   + +     +++ + E   ++ 
Sbjct: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQ-----KAVAESEEARRSV 1570

Query: 268  DQEIQTLKSQTGGPREALEAAEREE--TQQKVQDLETRNAELEHQLRAMERSLEEARAER 325
            D  +  ++++     E++  +ERE   T  +V  LE      E +LRA +  + + +A  
Sbjct: 1571 DGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANE 1630

Query: 326  ERARAEVGRAAQLLDVS 342
             +   +  R  ++LD S
Sbjct: 1631 TKLEGDKRRLKEVLDAS 1647



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 45/170 (26%), Positives = 71/170 (41%), Gaps = 4/170 (2%)

Query: 191  ALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGE-KE 249
            A +     L   L  A  A ++ R+Q  +   + + LR  VA+LE Q         + +E
Sbjct: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLRE 1817

Query: 250  GLGQGQSLEQLEA-LVQTKDQEIQTLKSQTGGPREALEA--AEREETQQKVQDLETRNAE 306
             L Q Q  E      VQ    E + L+ + G  + AL    AE+ E ++    LE     
Sbjct: 1818 VLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA 1877

Query: 307  LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
            L   L  +ER    +  +  R  AE GR  + L  +  EL+E +  + +L
Sbjct: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQL 1927



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 56/201 (27%), Positives = 85/201 (42%), Gaps = 33/201 (16%)

Query: 150  GEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAA 209
            GE      Q  +A G  + ++L+++L +   GE         LQD    L   L     A
Sbjct: 1796 GEVADLELQRVEAEG--QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRA 1853

Query: 210  AAQWRQQLEAQRAEAER-----------LRQRVAELEAQAASE----VTPTGEKEGLGQ- 253
             AQ    LEA++ E ER           LR+ + ++E +        V  + EK  L + 
Sbjct: 1854 LAQ----LEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRT 1909

Query: 254  --GQSLEQLEALVQTKDQEIQTLK-SQTGGPREALEAAERE--ETQQKVQDLETRNAELE 308
              G  LE  EA  Q +  E Q +   Q+  P +    A+++  E QQ+V+ L +  A+ E
Sbjct: 1910 LTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTE 1969

Query: 309  HQLRAMERSLEEARAERERAR 329
              L A E      RA R+R R
Sbjct: 1970 RTLEARE------RAHRQRVR 1984



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 11/165 (6%)

Query: 202 ALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQ--AASEVTPTGEKEGLGQGQSLEQ 259
           AL +        R + EA +     LR+++++ E++  A  E       +  G  Q+ E 
Sbjct: 527 ALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586

Query: 260 LEALVQTKDQEIQTLKSQTGGPREALEAAER--EETQQKVQDLETRNAELEHQLRAMERS 317
            +  VQ      + L  +      +L+ A++  EE +Q+ + L+    EL  Q   +E  
Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646

Query: 318 LEEARAERERARAEVGRAAQLLD-------VSLFELSELREGLAR 355
            E+A  +  R R E+ R+ + L+       V   EL E+RE L+R
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSR 691



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 66/274 (24%), Positives = 112/274 (40%), Gaps = 31/274 (11%)

Query: 104  EKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAP 163
            E+   + + A L R       EL +    ++  +   + L       +E L  S+S    
Sbjct: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVK 1653

Query: 164  GPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLE----- 218
               +R  L+  L    +G    EA+  ALQD  + L   + ++   A   +  +E     
Sbjct: 1654 LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA 1713

Query: 219  -AQRAEAE-RLRQRV---AELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQT 273
             A+  E+E  LR +V    E  AQ+++ +  T +K           L+  +   + + Q 
Sbjct: 1714 LAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKN--------LHLQKALTACEHDRQV 1765

Query: 274  LKSQTGGPREALEAAEREETQ--QKVQDLETRNAELEHQLRAMERSLEEARAERERARAE 331
            L+ +    R+AL  A ++ +   ++VQ L    A+LE Q    E  L++ R E  R R E
Sbjct: 1766 LQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR-EVLRQRQE 1824

Query: 332  VGRAAQLLDVSLFE---------LSELREGLARL 356
             G AA L  V   +         L  L+  LA+L
Sbjct: 1825 -GEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 47/170 (27%), Positives = 72/170 (42%), Gaps = 28/170 (16%)

Query: 192  LQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGL 251
            L+D+ + L   L EA     + ++  E QR EA  LR+ + E            G KE  
Sbjct: 1166 LEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGE------------GAKERE 1213

Query: 252  GQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLE---TRNAELE 308
               +S E+L + V+  + E  +LK               E+ +QK+  LE   T   +  
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLK------------LANEDKEQKLALLEEARTAVGKEA 1261

Query: 309  HQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELS-ELREGLARLA 357
             +LR   + +E +R E  R   E+ R  ++LD     L  EL E   RLA
Sbjct: 1262 GELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 30/241 (12%)

Query: 132 GLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFA 191
           GL+  + P  P  S+ G G     R  S      +    +   L +  +        + A
Sbjct: 486 GLSGQRTPSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA 544

Query: 192 LQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRV---------AELEAQ---AA 239
            QD    L G LR+  + +   R+ LE Q    +RLR +          A+ E Q   +A
Sbjct: 545 SQD----LLGTLRKQLSDSESERRALEEQ---LQRLRDKTDGAMQAHEDAQREVQRLRSA 597

Query: 240 SEVTPTGEKEGLGQGQSLEQLEALVQTKDQE-IQTLKSQTGGPREALEAAEREETQQKVQ 298
           +E+  + EK  L     + Q +A    +++E +Q  + +    R+ LE    EE +  VQ
Sbjct: 598 NELL-SREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE----EEQEDAVQ 652

Query: 299 DLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
           D     A +  +L    R LE+   +R     E+    + L  +  +   L+   A +AE
Sbjct: 653 D----GARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAE 708

Query: 359 A 359
           A
Sbjct: 709 A 709



 Score = 36.2 bits (82), Expect = 0.047
 Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 11/172 (6%)

Query: 187 AEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTG 246
           A   +LQ+ N  L   L       AQ R + +    +   + +R+ +       E+  T 
Sbjct: 74  ASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELE-TQ 132

Query: 247 EKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAE 306
           E  GL + QS+E    L + +    + L++   G +   +  +R   Q K+   + R +E
Sbjct: 133 EPRGLVR-QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR--LQGKILQYKKRCSE 189

Query: 307 LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
           LE QL  +ERS      E E+ R      +Q L+ +L  L E ++  A LA+
Sbjct: 190 LEQQL--LERS-----GELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQ 234



 Score = 35.8 bits (81), Expect = 0.061
 Identities = 45/169 (26%), Positives = 72/169 (42%), Gaps = 27/169 (15%)

Query: 203 LREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEA 262
           +REA + A   R  L+A++AE      +      +    +T    +E   Q  SL +L A
Sbjct: 685 VREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQ-DSLSKLSA 743

Query: 263 LVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
           L ++  Q+   +  L +Q    + AL+  +R+  Q+                R  +  LE
Sbjct: 744 LNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV------------AREEQERLE 791

Query: 320 EARAERERAR---------AEVGRAA--QLLDVSLFELSELREGLARLA 357
           E R E+E AR         AE  + A  Q L     E S+L+E LA+L+
Sbjct: 792 ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840



 Score = 34.7 bits (78), Expect = 0.14
 Identities = 42/169 (24%), Positives = 71/169 (42%), Gaps = 18/169 (10%)

Query: 168 RERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER- 226
           R+ L+  L      +   E +   L+   ++L   L + +   +   Q+LE  R EA+R 
Sbjct: 801 RQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQ 860

Query: 227 ---LRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPRE 283
              L +   E EA A         KE  G    L   E   +T  +E   L+ +    +E
Sbjct: 861 VEALERAAREKEALA---------KEHAGLAVQLVAAEREGRTLSEEATRLRLE----KE 907

Query: 284 ALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEV 332
           ALE +   E Q+++  LE R  +LE + +A+  + E    E    R ++
Sbjct: 908 ALEGS-LFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQI 955



 Score = 34.7 bits (78), Expect = 0.14
 Identities = 51/217 (23%), Positives = 85/217 (39%), Gaps = 51/217 (23%)

Query: 192  LQDSNNKLAGALREANAAAAQWRQQLEAQR--------AEAERLRQRVAELEAQA----- 238
            LQ    +   A RE  A  AQ + QL+ ++        AE E L + +A L+ +      
Sbjct: 995  LQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL 1054

Query: 239  -------------ASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREAL 285
                          SE T   EK  +G   SL  +   ++ + ++ Q+ + Q      AL
Sbjct: 1055 LAESEKQQALSLKESEKTALSEKL-MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNAL 1113

Query: 286  EA------AEREET-----------QQKVQDLETRN-------AELEHQLRAMERSLEEA 321
             +      A+REE            Q++ +DL  +         EL  QLR +E + +  
Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173

Query: 322  RAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
            R E   A+ ++  + +  +V   E  ELR  L   A+
Sbjct: 1174 RRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210



 Score = 33.5 bits (75), Expect = 0.30
 Identities = 49/218 (22%), Positives = 87/218 (39%), Gaps = 30/218 (13%)

Query: 97   QHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFR 156
            Q L +   + QE + AA    +K QD   L    LG  S Q   + L +     E    R
Sbjct: 1813 QQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLG--SLQRALAQLEAEKREVERSALR 1870

Query: 157  SQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQ 216
             +        +R  L++ L +    +++   +   L     +L   L  A    A+ ++Q
Sbjct: 1871 LEK-------DRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923

Query: 217  LEAQRAEAERLRQR--VAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTL 274
            ++   A+   L Q    A+LE  A              Q Q LE     +Q + + +++ 
Sbjct: 1924 IQQLEAQVVVLEQSHSPAQLEVDA--------------QQQQLE-----LQQEVERLRSA 1964

Query: 275  KSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLR 312
            ++QT    EA E A R+  +   + + T   +L+ +LR
Sbjct: 1965 QAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELR 2002


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 66/283 (23%), Positives = 116/283 (40%), Gaps = 26/283 (9%)

Query: 82   DSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPS 141
            D     + GL  A  + L +  +  +++KE      ++   G    S A G      P  
Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL 1122

Query: 142  PLVSANGPGEEKLFRSQSADAPG---PTERERLKKMLSEGSVGEVQWEAEFFA--LQDSN 196
              + A     E+  + Q   A       E ER  +   + ++  +Q + E  A  L  S 
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQ 1182

Query: 197  NKLAGALREANA----------AAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTG 246
            + LA A RE  A          A  +W+ Q+   R EAER    ++ LE + +       
Sbjct: 1183 SALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVL 1242

Query: 247  EKEGLGQGQSLEQLEALVQTKDQEIQ----TLKSQTGGPREALEAAEREETQQKVQDLET 302
            EKE  G+ + L++L      K Q+++     L+++T     +  AAER    +  +++++
Sbjct: 1243 EKE--GESKELKRLVMAESEKSQKLEERLRLLQAETAS--NSARAAERSSALR--EEVQS 1296

Query: 303  RNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFE 345
               E E Q  A E   +E  ++ ERA  E+G+  +      F+
Sbjct: 1297 LREEAEKQRVASENLRQELTSQAERAE-ELGQELKAWQEKFFQ 1338



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 71/285 (24%), Positives = 124/285 (43%), Gaps = 29/285 (10%)

Query: 94  ASEQHLTQFAEKFQEVKEA--ARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGE 151
           +S  +L+Q  E+ ++  +A  ARL  + +    ELT+     A+ Q     L       +
Sbjct: 473 SSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLN---ATIQQQDQELAGLKQQAK 529

Query: 152 EK-------LFRSQSADAPGPTERERLKKMLS--EGSVGEVQWEAEFFALQDSNNKLAGA 202
           EK       L + + A      + E+L   L   E  + EV  E +    QD   +LA A
Sbjct: 530 EKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA-EKQEATRQDHAQQLATA 588

Query: 203 -------LREANAAAAQWRQQLEAQRAEAERLRQR--VAELEAQAASEVTPTGEKEGLGQ 253
                  LRE +AA  Q     + + A+ E L+Q+  VA     +A       ++E    
Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648

Query: 254 GQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRA 313
            + +E+L+A V+T  QE    ++Q       L + +++ T++  + +     +L+ QL+A
Sbjct: 649 SRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK--ERVAQEKDQLQEQLQA 706

Query: 314 MERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
           ++ SL+  +   E    E  RAA  L+     +SEL+     L E
Sbjct: 707 LKESLKVTKGSLEE---EKRRAADALEEQQRCISELKAETRSLVE 748



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 63/212 (29%), Positives = 89/212 (41%), Gaps = 24/212 (11%)

Query: 167  ERERLKKMLSEGSVGEV--QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLE----AQ 220
            ER R   M S+G   E   Q E E   L     +    L    AA A+   +L+     Q
Sbjct: 982  ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041

Query: 221  RAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQT----KDQEIQTLKS 276
            R E   L++ +A    +   +     +  GL   Q +++LE L QT    K+Q  +  K 
Sbjct: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ-IKELEELRQTVKQLKEQLAKKEKE 1100

Query: 277  QTGGPREALEAAEREE-TQQKVQDLETRNAELEHQLR-------AMERSLEEARAERERA 328
               G     EAA R E T  K++ L    ++LE Q +       ++ERSLE  RA    +
Sbjct: 1101 HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERA----S 1156

Query: 329  RAEVGRAAQLLDVSLFE-LSELREGLARLAEA 359
            RAE   A + L   L E   EL    + LA A
Sbjct: 1157 RAERDSALETLQGQLEEKAQELGHSQSALASA 1188



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 48/204 (23%), Positives = 94/204 (46%), Gaps = 33/204 (16%)

Query: 151  EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
            EE   +   +D     ++++LK + ++G  GE Q EA+   LQ   N+L   L +   AA
Sbjct: 1552 EELSKKLADSDQASKVQQQKLKAVQAQG--GESQQEAQ--RLQAQLNELQAQLSQKEQAA 1607

Query: 211  AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQE 270
              ++ Q+E  +   +  +Q+  EL+ Q                 +SLEQL    Q +++E
Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQL----------------RSLEQL----QKENKE 1647

Query: 271  IQTLKSQTGG--PREALEAAEREET----QQKVQDLETRNAELEHQLRAMER---SLEEA 321
            ++    + G    +  L+  E E+T      +V+ LE + A  + QLR + +   + +  
Sbjct: 1648 LRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDAL 1707

Query: 322  RAERERARAEVGRAAQLLDVSLFE 345
            ++   +A+ ++  +   LD+S  E
Sbjct: 1708 KSREPQAKPQLDLSIDSLDLSCEE 1731



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 67/295 (22%), Positives = 113/295 (38%), Gaps = 53/295 (17%)

Query: 95   SEQHLTQFAEKFQE----VKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPG 150
            S+Q   Q+   FQE    +KE    AR++ Q+  E  +   G+ SH              
Sbjct: 820  SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA---GIESHS------------- 863

Query: 151  EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
            E ++ R Q+  A       R  + + E  V   +   +   LQ+   K+A   +E     
Sbjct: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE---KMAATSKEVARLE 920

Query: 211  AQWRQQLEAQRAEAERLRQRVAE--------LEAQAASEVTPTG------EKEGLGQGQS 256
               R+  E Q   +  L +  A         LE Q   +   T       E+E    G  
Sbjct: 921  TLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNE 980

Query: 257  LEQLEALVQT-----------KDQEIQTLKSQTGGPRE--ALEAAEREETQQKVQDLETR 303
            LE+L A +             +++E+  L  + G  +   ALE A R E + ++Q+    
Sbjct: 981  LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALN- 1039

Query: 304  NAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
              E   +   ++ +L  A  E+E    E+ +   L    + EL ELR+ + +L E
Sbjct: 1040 --EQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKE 1092



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 64/265 (24%), Positives = 112/265 (42%), Gaps = 13/265 (4%)

Query: 97   QHLTQFAEKFQEVKEAARLAREKS-QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLF 155
            Q LT  AE+ +E+ +  +  +EK  Q    L++  L   S Q   S L+ A     + L 
Sbjct: 1313 QELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPA-----KHLC 1367

Query: 156  RSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ 215
            +   A+     +R R +   S+ + G ++  AE    Q    +L   LR+  A   +  Q
Sbjct: 1368 QQLQAEQAAAEKRHREELEQSKQAAGGLR--AELLRAQRELGELI-PLRQKVAEQERTAQ 1424

Query: 216  QLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
            QL A++A        + +     A E    GE+  LG+ Q LE    L Q +++ +Q L 
Sbjct: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGR-QFLEV--ELDQAREKYVQELA 1481

Query: 276  SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRA 335
            +        L   +RE  Q   ++LE   A+ E     +    +  + ER++  A+V + 
Sbjct: 1482 AVRADAETRLAEVQRE-AQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL 1540

Query: 336  AQLLDVSLFELSELREGLARLAEAA 360
                     ++ EL + LA   +A+
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQAS 1565



 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 44/170 (25%), Positives = 79/170 (46%), Gaps = 20/170 (11%)

Query: 194  DSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE---VTPTGEKEG 250
            D+  +LA   REA + A    ++LE   A+ E  + +V E   +   E   +T   E+  
Sbjct: 1486 DAETRLAEVQREAQSTA----RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE 1541

Query: 251  LGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAERE--ETQQKVQDLETRNAELE 308
            + Q +  +Q+E L +      Q  K Q    ++ L+A + +  E+QQ+ Q L+ +  EL+
Sbjct: 1542 VFQREQTKQVEELSKKLADSDQASKVQ----QQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597

Query: 309  HQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
             QL   E++ E  + + E+A+          D    +  EL+E L  L +
Sbjct: 1598 AQLSQKEQAAEHYKLQMEKAKTH-------YDAKKQQNQELQEQLRSLEQ 1640



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/189 (24%), Positives = 81/189 (42%), Gaps = 17/189 (8%)

Query: 176  SEGSVGEVQWEAEFFA--LQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLR--QRV 231
            +E  + EVQ EA+  A  L+    K  GA  +      +++++ +   A+ E+L   QR 
Sbjct: 1487 AETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546

Query: 232  AELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAERE 291
               + +  S+     ++    Q Q L+ ++A      QE Q L++Q    +  L   E+ 
Sbjct: 1547 QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606

Query: 292  ETQQKVQDLETR---------NAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVS 342
                K+Q  + +         N EL+ QLR    SLE+ + E +  RAE  R    L  +
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLR----SLEQLQKENKELRAEAERLGHELQQA 1662

Query: 343  LFELSELRE 351
              +  E  +
Sbjct: 1663 GLKTKEAEQ 1671



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 46/191 (24%), Positives = 76/191 (39%), Gaps = 22/191 (11%)

Query: 184 QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVT 243
           Q + +   L + N  L+  LRE  +   Q +  L     E  +  Q   E +AQ   E++
Sbjct: 308 QMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELS 367

Query: 244 PT-------GEKEGLGQGQSLEQLEALVQTKDQEIQ--------TLKSQTGGPREALEAA 288
                     EK  + QG+  +  E L Q +D   Q         L+ +T     A  AA
Sbjct: 368 AALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAA 427

Query: 289 EREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSE 348
              + Q +V+ LET   + E +L A     EE + +      +       L  S+  LS+
Sbjct: 428 NNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITD-------LQSSISNLSQ 480

Query: 349 LREGLARLAEA 359
            +E L + ++A
Sbjct: 481 AKEELEQASQA 491



 Score = 38.1 bits (87), Expect = 0.012
 Identities = 59/271 (21%), Positives = 109/271 (40%), Gaps = 51/271 (18%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
            +EK Q+++E  RL + ++       +        +V      S     E++   S++   
Sbjct: 1259 SEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ-----SLREEAEKQRVASENLRQ 1313

Query: 163  PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKL------AGALREANAAAAQWRQQ 216
               ++ ER +++  E       W+ +FF  + + + L        AL      A    QQ
Sbjct: 1314 ELTSQAERAEELGQELKA----WQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ 1369

Query: 217  LEAQRAEAERLRQRVAELEAQAA--------------SEVTPTGEKEGLGQGQSLEQLEA 262
            L+A++A AE+  +   E   QAA               E+ P  +K    Q ++ +QL A
Sbjct: 1370 LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVA-EQERTAQQLRA 1428

Query: 263  LVQTKDQEIQTLKSQTG--------------GPREALEAAEREETQQKVQDL-------E 301
               +  +++  LK   G                R+ LE    +  ++ VQ+L       E
Sbjct: 1429 EKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE 1488

Query: 302  TRNAELEHQLRAMERSLEEARAERERARAEV 332
            TR AE++ + ++  R LE   A+ E A+ +V
Sbjct: 1489 TRLAEVQREAQSTARELEVMTAKYEGAKVKV 1519


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)

Query: 150  GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
            GE +  R+++ +A         E ERL++ + + S  + Q E E  +   +  + A   +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532

Query: 205  EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
             A  A  + R Q E      ++AE ER RQ             AEL+++ AS    T + 
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592

Query: 249  EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
            E     +SL++    V    +E +    Q      A E AERE  + +++  E     L+
Sbjct: 1593 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647

Query: 309  HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
             +  A ++SL +A AE+++  AE              R  +L +  L +  +L EG A+ 
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707

Query: 357  AEAA 360
              AA
Sbjct: 1708 RLAA 1711



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
            AE+  + K  A+   EK ++  E  +   G A  Q      ++     +++     +A  
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707

Query: 163  PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
                E+E L ++ +E   GE Q        Q    +LA   REA AAA Q RQ+LEA+ A
Sbjct: 1708 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1758

Query: 223  EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
            +        AE+E   AS+     E                  T ++  Q L+++ G  R
Sbjct: 1759 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1797

Query: 283  EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
            E  E A R         L     E + Q +  E      RAE ER  AE    +G A +L
Sbjct: 1798 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848

Query: 339  ---LDVSLFELSELREGLARLAE 358
                +++L E     E L RLAE
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAE 1871



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)

Query: 104  EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
            EK Q V+EA RL  E    Q   EL    A  L   +   +  ++    G ++   ++  
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 160  ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
                   E ERLK  ++E S  + + E +    +    ++   L     A  +     Q 
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433

Query: 217  LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
            LE QR +    AERLR+ +AELE +       A      + E + + Q Q L++ +AL Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493

Query: 266  T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
            +    KD  +Q  +   Q     E L   E  + QQ  ++ + +  ++E + + +  S+E
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553

Query: 320  EARAERERARAEVGRAAQLL 339
            EAR  +  A   V R  + L
Sbjct: 2554 EARRRQHEAEEGVRRKQEEL 2573



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)

Query: 151  EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
            EE+L   Q A+     ERERL         ++ L+E     + Q E E   LQ    ++ 
Sbjct: 1347 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1398

Query: 201  GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
              +     AA   +QQ  + + E ++LRQ  +E E QA +      E+  L   + +   
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1457

Query: 259  --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
              QLEA  + +   + E+Q L+++        R+A E AER   Q + +    R AE+E 
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517

Query: 309  ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
                             L+A+E   L+   AER   +AEV RA Q+
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)

Query: 209  AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
            AA +  ++L+A+  EA RLR+R  +       L  +AA +     EK      Q  EQ L
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065

Query: 261  EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
            +  +Q +   +  L+ +    R A E AE       RE  Q  ++V++ E      E Q 
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125

Query: 312  RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
            +A  ++   A   R+ A  E  R AQ    +L
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)

Query: 167  ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
            E ERLK+   E +    Q +A    L+    + A    +A  AA + +Q  +A+  + ++
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172

Query: 227  LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
              ++    +AQ   E+T                            E   Q   +E+    
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232

Query: 264  VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
            V+ + +E+  LK++      AL   +++ TQ+ +Q+   +  ++  +   +  + +EA  
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292

Query: 324  ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
             R+ A  ++ +   L +  L E  +  +   RL AEA
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2329



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)

Query: 110  KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
            +E ARL RE +    +       LA  +     L+++    EE        ++   +E+ 
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1785

Query: 170  RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
            + +     G   E+  EA          K    L E +AA    RQ+ EA+R  AE+L  
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1841

Query: 230  RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
                   +  +E+    EKE        E+L  L + +  + + L+ Q    +  +E   
Sbjct: 1842 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 287  -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
                 A++ E  +QK  V+D   +  ++E ++ A++ S E+A A +     E+GR
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)

Query: 94   ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
            A  + L + AE   E  +  RL  + +Q   ++      L   +   S L    G  E+ 
Sbjct: 1861 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1916

Query: 154  LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
            L + +  +     E   LK    + + G+ + E E   ++ +      +  +A   AA+ 
Sbjct: 1917 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972

Query: 214  RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
            RQ   + E +R EAE              R R+   E       + + A  +    E+E 
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032

Query: 251  -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
                 L Q  + ++L+A        VQ K+QE+       Q++  Q  G  EA   A  E
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092

Query: 292  ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
              + +VQ  E   A+   Q+   ER L+++  E+ +ARA+   AA+ L        E  +
Sbjct: 2093 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2144

Query: 352  GLARLAEA 359
              AR A+A
Sbjct: 2145 EAARRAQA 2152



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
            A+  ++V+EA RL ++ +++  +  + A   A      +   +A     E+  L + Q+A
Sbjct: 2105 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163

Query: 161  DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
            DA    E E+ KK   +    + Q E E   L+              +   +L     EA
Sbjct: 2164 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219

Query: 207  NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
                +Q  ++L + R + E L +  A +EA+  + +      T    +E   + + + + 
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279

Query: 261  EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
             A +    QE   ++ L  +    + AL     +E  Q VQ+     AE E   +  E +
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2339

Query: 318  LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
             E+AR    R + +  + AQ       +L+E  +G  R  EA
Sbjct: 2340 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2370



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)

Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
           EE Q +V       DL +  A+L    R + +S+EE RA+ ERAR++ G+
Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 581


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)

Query: 150  GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
            GE +  R+++ +A         E ERL++ + + S  + Q E E  +   +  + A   +
Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536

Query: 205  EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
             A  A  + R Q E      ++AE ER RQ             AEL+++ AS    T + 
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596

Query: 249  EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
            E     +SL++    V    +E +    Q      A E AERE  + +++  E     L+
Sbjct: 1597 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651

Query: 309  HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
             +  A ++SL +A AE+++  AE              R  +L +  L +  +L EG A+ 
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711

Query: 357  AEAA 360
              AA
Sbjct: 1712 RLAA 1715



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
            AE+  + K  A+   EK ++  E  +   G A  Q      ++     +++     +A  
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711

Query: 163  PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
                E+E L ++ +E   GE Q        Q    +LA   REA AAA Q RQ+LEA+ A
Sbjct: 1712 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1762

Query: 223  EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
            +        AE+E   AS+     E                  T ++  Q L+++ G  R
Sbjct: 1763 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1801

Query: 283  EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
            E  E A R         L     E + Q +  E      RAE ER  AE    +G A +L
Sbjct: 1802 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1852

Query: 339  ---LDVSLFELSELREGLARLAE 358
                +++L E     E L RLAE
Sbjct: 1853 KTEAEIALKEKEAENERLRRLAE 1875



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)

Query: 104  EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
            EK Q V+EA RL  E    Q   EL    A  L   +   +  ++    G ++   ++  
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377

Query: 160  ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
                   E ERLK  ++E S  + + E +    +    ++   L     A  +     Q 
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437

Query: 217  LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
            LE QR +    AERLR+ +AELE +       A      + E + + Q Q L++ +AL Q
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497

Query: 266  T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
            +    KD  +Q  +   Q     E L   E  + QQ  ++ + +  ++E + + +  S+E
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2557

Query: 320  EARAERERARAEVGRAAQLL 339
            EAR  +  A   V R  + L
Sbjct: 2558 EARRRQHEAEEGVRRKQEEL 2577



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)

Query: 151  EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
            EE+L   Q A+     ERERL         ++ L+E     + Q E E   LQ    ++ 
Sbjct: 1351 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1402

Query: 201  GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
              +     AA   +QQ  + + E ++LRQ  +E E QA +      E+  L   + +   
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1461

Query: 259  --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
              QLEA  + +   + E+Q L+++        R+A E AER   Q + +    R AE+E 
Sbjct: 1462 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521

Query: 309  ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
                             L+A+E   L+   AER   +AEV RA Q+
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1567



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)

Query: 209  AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
            AA +  ++L+A+  EA RLR+R  +       L  +AA +     EK      Q  EQ L
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2069

Query: 261  EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
            +  +Q +   +  L+ +    R A E AE       RE  Q  ++V++ E      E Q 
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129

Query: 312  RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
            +A  ++   A   R+ A  E  R AQ    +L
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)

Query: 167  ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
            E ERLK+   E +    Q +A    L+    + A    +A  AA + +Q  +A+  + ++
Sbjct: 2117 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2176

Query: 227  LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
              ++    +AQ   E+T                            E   Q   +E+    
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236

Query: 264  VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
            V+ + +E+  LK++      AL   +++ TQ+ +Q+   +  ++  +   +  + +EA  
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296

Query: 324  ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
             R+ A  ++ +   L +  L E  +  +   RL AEA
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2333



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)

Query: 110  KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
            +E ARL RE +    +       LA  +     L+++    EE        ++   +E+ 
Sbjct: 1738 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1789

Query: 170  RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
            + +     G   E+  EA          K    L E +AA    RQ+ EA+R  AE+L  
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1845

Query: 230  RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
                   +  +E+    EKE        E+L  L + +  + + L+ Q    +  +E   
Sbjct: 1846 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899

Query: 287  -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
                 A++ E  +QK  V+D   +  ++E ++ A++ S E+A A +     E+GR
Sbjct: 1900 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)

Query: 94   ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
            A  + L + AE   E  +  RL  + +Q   ++      L   +   S L    G  E+ 
Sbjct: 1865 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1920

Query: 154  LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
            L + +  +     E   LK    + + G+ + E E   ++ +      +  +A   AA+ 
Sbjct: 1921 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976

Query: 214  RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
            RQ   + E +R EAE              R R+   E       + + A  +    E+E 
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036

Query: 251  -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
                 L Q  + ++L+A        VQ K+QE+       Q++  Q  G  EA   A  E
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096

Query: 292  ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
              + +VQ  E   A+   Q+   ER L+++  E+ +ARA+   AA+ L        E  +
Sbjct: 2097 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2148

Query: 352  GLARLAEA 359
              AR A+A
Sbjct: 2149 EAARRAQA 2156



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
            A+  ++V+EA RL ++ +++  +  + A   A      +   +A     E+  L + Q+A
Sbjct: 2109 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167

Query: 161  DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
            DA    E E+ KK   +    + Q E E   L+              +   +L     EA
Sbjct: 2168 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2223

Query: 207  NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
                +Q  ++L + R + E L +  A +EA+  + +      T    +E   + + + + 
Sbjct: 2224 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283

Query: 261  EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
             A +    QE   ++ L  +    + AL     +E  Q VQ+     AE E   +  E +
Sbjct: 2284 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2343

Query: 318  LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
             E+AR    R + +  + AQ       +L+E  +G  R  EA
Sbjct: 2344 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2374



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)

Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
           EE Q +V       DL +  A+L    R + +S+EE RA+ ERAR++ G+
Sbjct: 537 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 585


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)

Query: 150  GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
            GE +  R+++ +A         E ERL++ + + S  + Q E E  +   +  + A   +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532

Query: 205  EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
             A  A  + R Q E      ++AE ER RQ             AEL+++ AS    T + 
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592

Query: 249  EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
            E     +SL++    V    +E +    Q      A E AERE  + +++  E     L+
Sbjct: 1593 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647

Query: 309  HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
             +  A ++SL +A AE+++  AE              R  +L +  L +  +L EG A+ 
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707

Query: 357  AEAA 360
              AA
Sbjct: 1708 RLAA 1711



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
            AE+  + K  A+   EK ++  E  +   G A  Q      ++     +++     +A  
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707

Query: 163  PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
                E+E L ++ +E   GE Q        Q    +LA   REA AAA Q RQ+LEA+ A
Sbjct: 1708 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1758

Query: 223  EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
            +        AE+E   AS+     E                  T ++  Q L+++ G  R
Sbjct: 1759 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1797

Query: 283  EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
            E  E A R         L     E + Q +  E      RAE ER  AE    +G A +L
Sbjct: 1798 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848

Query: 339  ---LDVSLFELSELREGLARLAE 358
                +++L E     E L RLAE
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAE 1871



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)

Query: 104  EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
            EK Q V+EA RL  E    Q   EL    A  L   +   +  ++    G ++   ++  
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 160  ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
                   E ERLK  ++E S  + + E +    +    ++   L     A  +     Q 
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433

Query: 217  LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
            LE QR +    AERLR+ +AELE +       A      + E + + Q Q L++ +AL Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493

Query: 266  T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
            +    KD  +Q  +   Q     E L   E  + QQ  ++ + +  ++E + + +  S+E
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553

Query: 320  EARAERERARAEVGRAAQLL 339
            EAR  +  A   V R  + L
Sbjct: 2554 EARRRQHEAEEGVRRKQEEL 2573



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)

Query: 151  EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
            EE+L   Q A+     ERERL         ++ L+E     + Q E E   LQ    ++ 
Sbjct: 1347 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1398

Query: 201  GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
              +     AA   +QQ  + + E ++LRQ  +E E QA +      E+  L   + +   
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1457

Query: 259  --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
              QLEA  + +   + E+Q L+++        R+A E AER   Q + +    R AE+E 
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517

Query: 309  ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
                             L+A+E   L+   AER   +AEV RA Q+
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)

Query: 209  AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
            AA +  ++L+A+  EA RLR+R  +       L  +AA +     EK      Q  EQ L
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065

Query: 261  EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
            +  +Q +   +  L+ +    R A E AE       RE  Q  ++V++ E      E Q 
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125

Query: 312  RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
            +A  ++   A   R+ A  E  R AQ    +L
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)

Query: 167  ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
            E ERLK+   E +    Q +A    L+    + A    +A  AA + +Q  +A+  + ++
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172

Query: 227  LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
              ++    +AQ   E+T                            E   Q   +E+    
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232

Query: 264  VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
            V+ + +E+  LK++      AL   +++ TQ+ +Q+   +  ++  +   +  + +EA  
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292

Query: 324  ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
             R+ A  ++ +   L +  L E  +  +   RL AEA
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2329



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)

Query: 110  KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
            +E ARL RE +    +       LA  +     L+++    EE        ++   +E+ 
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1785

Query: 170  RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
            + +     G   E+  EA          K    L E +AA    RQ+ EA+R  AE+L  
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1841

Query: 230  RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
                   +  +E+    EKE        E+L  L + +  + + L+ Q    +  +E   
Sbjct: 1842 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 287  -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
                 A++ E  +QK  V+D   +  ++E ++ A++ S E+A A +     E+GR
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)

Query: 94   ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
            A  + L + AE   E  +  RL  + +Q   ++      L   +   S L    G  E+ 
Sbjct: 1861 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1916

Query: 154  LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
            L + +  +     E   LK    + + G+ + E E   ++ +      +  +A   AA+ 
Sbjct: 1917 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972

Query: 214  RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
            RQ   + E +R EAE              R R+   E       + + A  +    E+E 
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032

Query: 251  -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
                 L Q  + ++L+A        VQ K+QE+       Q++  Q  G  EA   A  E
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092

Query: 292  ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
              + +VQ  E   A+   Q+   ER L+++  E+ +ARA+   AA+ L        E  +
Sbjct: 2093 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2144

Query: 352  GLARLAEA 359
              AR A+A
Sbjct: 2145 EAARRAQA 2152



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
            A+  ++V+EA RL ++ +++  +  + A   A      +   +A     E+  L + Q+A
Sbjct: 2105 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163

Query: 161  DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
            DA    E E+ KK   +    + Q E E   L+              +   +L     EA
Sbjct: 2164 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219

Query: 207  NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
                +Q  ++L + R + E L +  A +EA+  + +      T    +E   + + + + 
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279

Query: 261  EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
             A +    QE   ++ L  +    + AL     +E  Q VQ+     AE E   +  E +
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2339

Query: 318  LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
             E+AR    R + +  + AQ       +L+E  +G  R  EA
Sbjct: 2340 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2370



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)

Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
           EE Q +V       DL +  A+L    R + +S+EE RA+ ERAR++ G+
Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 581


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)

Query: 150  GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
            GE +  R+++ +A         E ERL++ + + S  + Q E E  +   +  + A   +
Sbjct: 1441 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500

Query: 205  EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
             A  A  + R Q E      ++AE ER RQ             AEL+++ AS    T + 
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560

Query: 249  EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
            E     +SL++    V    +E +    Q      A E AERE  + +++  E     L+
Sbjct: 1561 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615

Query: 309  HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
             +  A ++SL +A AE+++  AE              R  +L +  L +  +L EG A+ 
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675

Query: 357  AEAA 360
              AA
Sbjct: 1676 RLAA 1679



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
            AE+  + K  A+   EK ++  E  +   G A  Q      ++     +++     +A  
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675

Query: 163  PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
                E+E L ++ +E   GE Q        Q    +LA   REA AAA Q RQ+LEA+ A
Sbjct: 1676 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1726

Query: 223  EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
            +        AE+E   AS+     E                  T ++  Q L+++ G  R
Sbjct: 1727 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1765

Query: 283  EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
            E  E A R         L     E + Q +  E      RAE ER  AE    +G A +L
Sbjct: 1766 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1816

Query: 339  ---LDVSLFELSELREGLARLAE 358
                +++L E     E L RLAE
Sbjct: 1817 KTEAEIALKEKEAENERLRRLAE 1839



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)

Query: 104  EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
            EK Q V+EA RL  E    Q   EL    A  L   +   +  ++    G ++   ++  
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341

Query: 160  ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
                   E ERLK  ++E S  + + E +    +    ++   L     A  +     Q 
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401

Query: 217  LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
            LE QR +    AERLR+ +AELE +       A      + E + + Q Q L++ +AL Q
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461

Query: 266  T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
            +    KD  +Q  +   Q     E L   E  + QQ  ++ + +  ++E + + +  S+E
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2521

Query: 320  EARAERERARAEVGRAAQLL 339
            EAR  +  A   V R  + L
Sbjct: 2522 EARRRQHEAEEGVRRKQEEL 2541



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)

Query: 151  EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
            EE+L   Q A+     ERERL         ++ L+E     + Q E E   LQ    ++ 
Sbjct: 1315 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1366

Query: 201  GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
              +     AA   +QQ  + + E ++LRQ  +E E QA +      E+  L   + +   
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1425

Query: 259  --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
              QLEA  + +   + E+Q L+++        R+A E AER   Q + +    R AE+E 
Sbjct: 1426 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1485

Query: 309  ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
                             L+A+E   L+   AER   +AEV RA Q+
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1531



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)

Query: 209  AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
            AA +  ++L+A+  EA RLR+R  +       L  +AA +     EK      Q  EQ L
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2033

Query: 261  EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
            +  +Q +   +  L+ +    R A E AE       RE  Q  ++V++ E      E Q 
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093

Query: 312  RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
            +A  ++   A   R+ A  E  R AQ    +L
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)

Query: 167  ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
            E ERLK+   E +    Q +A    L+    + A    +A  AA + +Q  +A+  + ++
Sbjct: 2081 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2140

Query: 227  LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
              ++    +AQ   E+T                            E   Q   +E+    
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200

Query: 264  VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
            V+ + +E+  LK++      AL   +++ TQ+ +Q+   +  ++  +   +  + +EA  
Sbjct: 2201 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2260

Query: 324  ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
             R+ A  ++ +   L +  L E  +  +   RL AEA
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2297



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)

Query: 110  KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
            +E ARL RE +    +       LA  +     L+++    EE        ++   +E+ 
Sbjct: 1702 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1753

Query: 170  RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
            + +     G   E+  EA          K    L E +AA    RQ+ EA+R  AE+L  
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1809

Query: 230  RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
                   +  +E+    EKE        E+L  L + +  + + L+ Q    +  +E   
Sbjct: 1810 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863

Query: 287  -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
                 A++ E  +QK  V+D   +  ++E ++ A++ S E+A A +     E+GR
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)

Query: 94   ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
            A  + L + AE   E  +  RL  + +Q   ++      L   +   S L    G  E+ 
Sbjct: 1829 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1884

Query: 154  LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
            L + +  +     E   LK    + + G+ + E E   ++ +      +  +A   AA+ 
Sbjct: 1885 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940

Query: 214  RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
            RQ   + E +R EAE              R R+   E       + + A  +    E+E 
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000

Query: 251  -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
                 L Q  + ++L+A        VQ K+QE+       Q++  Q  G  EA   A  E
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060

Query: 292  ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
              + +VQ  E   A+   Q+   ER L+++  E+ +ARA+   AA+ L        E  +
Sbjct: 2061 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2112

Query: 352  GLARLAEA 359
              AR A+A
Sbjct: 2113 EAARRAQA 2120



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
            A+  ++V+EA RL ++ +++  +  + A   A      +   +A     E+  L + Q+A
Sbjct: 2073 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131

Query: 161  DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
            DA    E E+ KK   +    + Q E E   L+              +   +L     EA
Sbjct: 2132 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2187

Query: 207  NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
                +Q  ++L + R + E L +  A +EA+  + +      T    +E   + + + + 
Sbjct: 2188 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247

Query: 261  EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
             A +    QE   ++ L  +    + AL     +E  Q VQ+     AE E   +  E +
Sbjct: 2248 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2307

Query: 318  LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
             E+AR    R + +  + AQ       +L+E  +G  R  EA
Sbjct: 2308 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2338



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)

Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
           EE Q +V       DL +  A+L    R + +S+EE RA+ ERAR++ G+
Sbjct: 501 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 549


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)

Query: 150  GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
            GE +  R+++ +A         E ERL++ + + S  + Q E E  +   +  + A   +
Sbjct: 1610 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669

Query: 205  EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
             A  A  + R Q E      ++AE ER RQ             AEL+++ AS    T + 
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729

Query: 249  EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
            E     +SL++    V    +E +    Q      A E AERE  + +++  E     L+
Sbjct: 1730 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784

Query: 309  HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
             +  A ++SL +A AE+++  AE              R  +L +  L +  +L EG A+ 
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844

Query: 357  AEAA 360
              AA
Sbjct: 1845 RLAA 1848



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
            AE+  + K  A+   EK ++  E  +   G A  Q      ++     +++     +A  
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844

Query: 163  PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
                E+E L ++ +E   GE Q        Q    +LA   REA AAA Q RQ+LEA+ A
Sbjct: 1845 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1895

Query: 223  EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
            +        AE+E   AS+     E                  T ++  Q L+++ G  R
Sbjct: 1896 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1934

Query: 283  EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
            E  E A R         L     E + Q +  E      RAE ER  AE    +G A +L
Sbjct: 1935 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1985

Query: 339  ---LDVSLFELSELREGLARLAE 358
                +++L E     E L RLAE
Sbjct: 1986 KTEAEIALKEKEAENERLRRLAE 2008



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)

Query: 104  EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
            EK Q V+EA RL  E    Q   EL    A  L   +   +  ++    G ++   ++  
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510

Query: 160  ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
                   E ERLK  ++E S  + + E +    +    ++   L     A  +     Q 
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570

Query: 217  LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
            LE QR +    AERLR+ +AELE +       A      + E + + Q Q L++ +AL Q
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630

Query: 266  T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
            +    KD  +Q  +   Q     E L   E  + QQ  ++ + +  ++E + + +  S+E
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690

Query: 320  EARAERERARAEVGRAAQLL 339
            EAR  +  A   V R  + L
Sbjct: 2691 EARRRQHEAEEGVRRKQEEL 2710



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)

Query: 151  EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
            EE+L   Q A+     ERERL         ++ L+E     + Q E E   LQ    ++ 
Sbjct: 1484 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1535

Query: 201  GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
              +     AA   +QQ  + + E ++LRQ  +E E QA +      E+  L   + +   
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1594

Query: 259  --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
              QLEA  + +   + E+Q L+++        R+A E AER   Q + +    R AE+E 
Sbjct: 1595 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654

Query: 309  ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
                             L+A+E   L+   AER   +AEV RA Q+
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1700



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)

Query: 209  AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
            AA +  ++L+A+  EA RLR+R  +       L  +AA +     EK      Q  EQ L
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2202

Query: 261  EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
            +  +Q +   +  L+ +    R A E AE       RE  Q  ++V++ E      E Q 
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262

Query: 312  RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
            +A  ++   A   R+ A  E  R AQ    +L
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)

Query: 167  ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
            E ERLK+   E +    Q +A    L+    + A    +A  AA + +Q  +A+  + ++
Sbjct: 2250 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2309

Query: 227  LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
              ++    +AQ   E+T                            E   Q   +E+    
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369

Query: 264  VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
            V+ + +E+  LK++      AL   +++ TQ+ +Q+   +  ++  +   +  + +EA  
Sbjct: 2370 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2429

Query: 324  ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
             R+ A  ++ +   L +  L E  +  +   RL AEA
Sbjct: 2430 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2466



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)

Query: 110  KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
            +E ARL RE +    +       LA  +     L+++    EE        ++   +E+ 
Sbjct: 1871 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1922

Query: 170  RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
            + +     G   E+  EA          K    L E +AA    RQ+ EA+R  AE+L  
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1978

Query: 230  RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
                   +  +E+    EKE        E+L  L + +  + + L+ Q    +  +E   
Sbjct: 1979 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032

Query: 287  -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
                 A++ E  +QK  V+D   +  ++E ++ A++ S E+A A +     E+GR
Sbjct: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)

Query: 94   ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
            A  + L + AE   E  +  RL  + +Q   ++      L   +   S L    G  E+ 
Sbjct: 1998 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 2053

Query: 154  LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
            L + +  +     E   LK    + + G+ + E E   ++ +      +  +A   AA+ 
Sbjct: 2054 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109

Query: 214  RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
            RQ   + E +R EAE              R R+   E       + + A  +    E+E 
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169

Query: 251  -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
                 L Q  + ++L+A        VQ K+QE+       Q++  Q  G  EA   A  E
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229

Query: 292  ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
              + +VQ  E   A+   Q+   ER L+++  E+ +ARA+   AA+ L        E  +
Sbjct: 2230 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2281

Query: 352  GLARLAEA 359
              AR A+A
Sbjct: 2282 EAARRAQA 2289



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
            A+  ++V+EA RL ++ +++  +  + A   A      +   +A     E+  L + Q+A
Sbjct: 2242 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300

Query: 161  DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
            DA    E E+ KK   +    + Q E E   L+              +   +L     EA
Sbjct: 2301 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2356

Query: 207  NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
                +Q  ++L + R + E L +  A +EA+  + +      T    +E   + + + + 
Sbjct: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416

Query: 261  EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
             A +    QE   ++ L  +    + AL     +E  Q VQ+     AE E   +  E +
Sbjct: 2417 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2476

Query: 318  LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
             E+AR    R + +  + AQ       +L+E  +G  R  EA
Sbjct: 2477 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2507



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)

Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
           EE Q +V       DL +  A+L    R + +S+EE RA+ ERAR++ G+
Sbjct: 670 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 718


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)

Query: 150  GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
            GE +  R+++ +A         E ERL++ + + S  + Q E E  +   +  + A   +
Sbjct: 1451 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1510

Query: 205  EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
             A  A  + R Q E      ++AE ER RQ             AEL+++ AS    T + 
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570

Query: 249  EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
            E     +SL++    V    +E +    Q      A E AERE  + +++  E     L+
Sbjct: 1571 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625

Query: 309  HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
             +  A ++SL +A AE+++  AE              R  +L +  L +  +L EG A+ 
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685

Query: 357  AEAA 360
              AA
Sbjct: 1686 RLAA 1689



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
            AE+  + K  A+   EK ++  E  +   G A  Q      ++     +++     +A  
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685

Query: 163  PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
                E+E L ++ +E   GE Q        Q    +LA   REA AAA Q RQ+LEA+ A
Sbjct: 1686 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1736

Query: 223  EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
            +        AE+E   AS+     E                  T ++  Q L+++ G  R
Sbjct: 1737 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1775

Query: 283  EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
            E  E A R         L     E + Q +  E      RAE ER  AE    +G A +L
Sbjct: 1776 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1826

Query: 339  ---LDVSLFELSELREGLARLAE 358
                +++L E     E L RLAE
Sbjct: 1827 KTEAEIALKEKEAENERLRRLAE 1849



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)

Query: 104  EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
            EK Q V+EA RL  E    Q   EL    A  L   +   +  ++    G ++   ++  
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351

Query: 160  ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
                   E ERLK  ++E S  + + E +    +    ++   L     A  +     Q 
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411

Query: 217  LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
            LE QR +    AERLR+ +AELE +       A      + E + + Q Q L++ +AL Q
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471

Query: 266  T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
            +    KD  +Q  +   Q     E L   E  + QQ  ++ + +  ++E + + +  S+E
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531

Query: 320  EARAERERARAEVGRAAQLL 339
            EAR  +  A   V R  + L
Sbjct: 2532 EARRRQHEAEEGVRRKQEEL 2551



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)

Query: 151  EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
            EE+L   Q A+     ERERL         ++ L+E     + Q E E   LQ    ++ 
Sbjct: 1325 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1376

Query: 201  GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
              +     AA   +QQ  + + E ++LRQ  +E E QA +      E+  L   + +   
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1435

Query: 259  --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
              QLEA  + +   + E+Q L+++        R+A E AER   Q + +    R AE+E 
Sbjct: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495

Query: 309  ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
                             L+A+E   L+   AER   +AEV RA Q+
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1541



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)

Query: 209  AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
            AA +  ++L+A+  EA RLR+R  +       L  +AA +     EK      Q  EQ L
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2043

Query: 261  EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
            +  +Q +   +  L+ +    R A E AE       RE  Q  ++V++ E      E Q 
Sbjct: 2044 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103

Query: 312  RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
            +A  ++   A   R+ A  E  R AQ    +L
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)

Query: 167  ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
            E ERLK+   E +    Q +A    L+    + A    +A  AA + +Q  +A+  + ++
Sbjct: 2091 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2150

Query: 227  LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
              ++    +AQ   E+T                            E   Q   +E+    
Sbjct: 2151 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2210

Query: 264  VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
            V+ + +E+  LK++      AL   +++ TQ+ +Q+   +  ++  +   +  + +EA  
Sbjct: 2211 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2270

Query: 324  ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
             R+ A  ++ +   L +  L E  +  +   RL AEA
Sbjct: 2271 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2307



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)

Query: 110  KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
            +E ARL RE +    +       LA  +     L+++    EE        ++   +E+ 
Sbjct: 1712 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1763

Query: 170  RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
            + +     G   E+  EA          K    L E +AA    RQ+ EA+R  AE+L  
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1819

Query: 230  RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
                   +  +E+    EKE        E+L  L + +  + + L+ Q    +  +E   
Sbjct: 1820 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873

Query: 287  -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
                 A++ E  +QK  V+D   +  ++E ++ A++ S E+A A +     E+GR
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)

Query: 94   ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
            A  + L + AE   E  +  RL  + +Q   ++      L   +   S L    G  E+ 
Sbjct: 1839 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1894

Query: 154  LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
            L + +  +     E   LK    + + G+ + E E   ++ +      +  +A   AA+ 
Sbjct: 1895 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950

Query: 214  RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
            RQ   + E +R EAE              R R+   E       + + A  +    E+E 
Sbjct: 1951 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010

Query: 251  -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
                 L Q  + ++L+A        VQ K+QE+       Q++  Q  G  EA   A  E
Sbjct: 2011 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2070

Query: 292  ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
              + +VQ  E   A+   Q+   ER L+++  E+ +ARA+   AA+ L        E  +
Sbjct: 2071 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2122

Query: 352  GLARLAEA 359
              AR A+A
Sbjct: 2123 EAARRAQA 2130



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
            A+  ++V+EA RL ++ +++  +  + A   A      +   +A     E+  L + Q+A
Sbjct: 2083 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141

Query: 161  DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
            DA    E E+ KK   +    + Q E E   L+              +   +L     EA
Sbjct: 2142 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2197

Query: 207  NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
                +Q  ++L + R + E L +  A +EA+  + +      T    +E   + + + + 
Sbjct: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257

Query: 261  EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
             A +    QE   ++ L  +    + AL     +E  Q VQ+     AE E   +  E +
Sbjct: 2258 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2317

Query: 318  LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
             E+AR    R + +  + AQ       +L+E  +G  R  EA
Sbjct: 2318 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2348



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)

Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
           EE Q +V       DL +  A+L    R + +S+EE RA+ ERAR++ G+
Sbjct: 511 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 559


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)

Query: 150  GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
            GE +  R+++ +A         E ERL++ + + S  + Q E E  +   +  + A   +
Sbjct: 1459 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1518

Query: 205  EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
             A  A  + R Q E      ++AE ER RQ             AEL+++ AS    T + 
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1578

Query: 249  EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
            E     +SL++    V    +E +    Q      A E AERE  + +++  E     L+
Sbjct: 1579 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633

Query: 309  HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
             +  A ++SL +A AE+++  AE              R  +L +  L +  +L EG A+ 
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1693

Query: 357  AEAA 360
              AA
Sbjct: 1694 RLAA 1697



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
            AE+  + K  A+   EK ++  E  +   G A  Q      ++     +++     +A  
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1693

Query: 163  PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
                E+E L ++ +E   GE Q        Q    +LA   REA AAA Q RQ+LEA+ A
Sbjct: 1694 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1744

Query: 223  EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
            +        AE+E   AS+     E                  T ++  Q L+++ G  R
Sbjct: 1745 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1783

Query: 283  EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
            E  E A R         L     E + Q +  E      RAE ER  AE    +G A +L
Sbjct: 1784 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1834

Query: 339  ---LDVSLFELSELREGLARLAE 358
                +++L E     E L RLAE
Sbjct: 1835 KTEAEIALKEKEAENERLRRLAE 1857



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)

Query: 104  EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
            EK Q V+EA RL  E    Q   EL    A  L   +   +  ++    G ++   ++  
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359

Query: 160  ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
                   E ERLK  ++E S  + + E +    +    ++   L     A  +     Q 
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419

Query: 217  LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
            LE QR +    AERLR+ +AELE +       A      + E + + Q Q L++ +AL Q
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479

Query: 266  T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
            +    KD  +Q  +   Q     E L   E  + QQ  ++ + +  ++E + + +  S+E
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2539

Query: 320  EARAERERARAEVGRAAQLL 339
            EAR  +  A   V R  + L
Sbjct: 2540 EARRRQHEAEEGVRRKQEEL 2559



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)

Query: 151  EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
            EE+L   Q A+     ERERL         ++ L+E     + Q E E   LQ    ++ 
Sbjct: 1333 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1384

Query: 201  GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
              +     AA   +QQ  + + E ++LRQ  +E E QA +      E+  L   + +   
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1443

Query: 259  --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
              QLEA  + +   + E+Q L+++        R+A E AER   Q + +    R AE+E 
Sbjct: 1444 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1503

Query: 309  ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
                             L+A+E   L+   AER   +AEV RA Q+
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1549



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)

Query: 209  AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
            AA +  ++L+A+  EA RLR+R  +       L  +AA +     EK      Q  EQ L
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2051

Query: 261  EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
            +  +Q +   +  L+ +    R A E AE       RE  Q  ++V++ E      E Q 
Sbjct: 2052 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111

Query: 312  RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
            +A  ++   A   R+ A  E  R AQ    +L
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)

Query: 167  ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
            E ERLK+   E +    Q +A    L+    + A    +A  AA + +Q  +A+  + ++
Sbjct: 2099 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2158

Query: 227  LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
              ++    +AQ   E+T                            E   Q   +E+    
Sbjct: 2159 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2218

Query: 264  VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
            V+ + +E+  LK++      AL   +++ TQ+ +Q+   +  ++  +   +  + +EA  
Sbjct: 2219 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2278

Query: 324  ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
             R+ A  ++ +   L +  L E  +  +   RL AEA
Sbjct: 2279 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2315



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)

Query: 110  KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
            +E ARL RE +    +       LA  +     L+++    EE        ++   +E+ 
Sbjct: 1720 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1771

Query: 170  RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
            + +     G   E+  EA          K    L E +AA    RQ+ EA+R  AE+L  
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1827

Query: 230  RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
                   +  +E+    EKE        E+L  L + +  + + L+ Q    +  +E   
Sbjct: 1828 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881

Query: 287  -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
                 A++ E  +QK  V+D   +  ++E ++ A++ S E+A A +     E+GR
Sbjct: 1882 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)

Query: 94   ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
            A  + L + AE   E  +  RL  + +Q   ++      L   +   S L    G  E+ 
Sbjct: 1847 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1902

Query: 154  LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
            L + +  +     E   LK    + + G+ + E E   ++ +      +  +A   AA+ 
Sbjct: 1903 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958

Query: 214  RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
            RQ   + E +R EAE              R R+   E       + + A  +    E+E 
Sbjct: 1959 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018

Query: 251  -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
                 L Q  + ++L+A        VQ K+QE+       Q++  Q  G  EA   A  E
Sbjct: 2019 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2078

Query: 292  ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
              + +VQ  E   A+   Q+   ER L+++  E+ +ARA+   AA+ L        E  +
Sbjct: 2079 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2130

Query: 352  GLARLAEA 359
              AR A+A
Sbjct: 2131 EAARRAQA 2138



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
            A+  ++V+EA RL ++ +++  +  + A   A      +   +A     E+  L + Q+A
Sbjct: 2091 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2149

Query: 161  DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
            DA    E E+ KK   +    + Q E E   L+              +   +L     EA
Sbjct: 2150 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2205

Query: 207  NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
                +Q  ++L + R + E L +  A +EA+  + +      T    +E   + + + + 
Sbjct: 2206 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265

Query: 261  EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
             A +    QE   ++ L  +    + AL     +E  Q VQ+     AE E   +  E +
Sbjct: 2266 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2325

Query: 318  LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
             E+AR    R + +  + AQ       +L+E  +G  R  EA
Sbjct: 2326 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2356



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)

Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
           EE Q +V       DL +  A+L    R + +S+EE RA+ ERAR++ G+
Sbjct: 519 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 567


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)

Query: 150  GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
            GE +  R+++ +A         E ERL++ + + S  + Q E E  +   +  + A   +
Sbjct: 1500 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1559

Query: 205  EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
             A  A  + R Q E      ++AE ER RQ             AEL+++ AS    T + 
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619

Query: 249  EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
            E     +SL++    V    +E +    Q      A E AERE  + +++  E     L+
Sbjct: 1620 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674

Query: 309  HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
             +  A ++SL +A AE+++  AE              R  +L +  L +  +L EG A+ 
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1734

Query: 357  AEAA 360
              AA
Sbjct: 1735 RLAA 1738



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
            AE+  + K  A+   EK ++  E  +   G A  Q      ++     +++     +A  
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1734

Query: 163  PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
                E+E L ++ +E   GE Q        Q    +LA   REA AAA Q RQ+LEA+ A
Sbjct: 1735 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1785

Query: 223  EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
            +        AE+E   AS+     E                  T ++  Q L+++ G  R
Sbjct: 1786 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1824

Query: 283  EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
            E  E A R         L     E + Q +  E      RAE ER  AE    +G A +L
Sbjct: 1825 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1875

Query: 339  ---LDVSLFELSELREGLARLAE 358
                +++L E     E L RLAE
Sbjct: 1876 KTEAEIALKEKEAENERLRRLAE 1898



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)

Query: 104  EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
            EK Q V+EA RL  E    Q   EL    A  L   +   +  ++    G ++   ++  
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400

Query: 160  ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
                   E ERLK  ++E S  + + E +    +    ++   L     A  +     Q 
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460

Query: 217  LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
            LE QR +    AERLR+ +AELE +       A      + E + + Q Q L++ +AL Q
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520

Query: 266  T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
            +    KD  +Q  +   Q     E L   E  + QQ  ++ + +  ++E + + +  S+E
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580

Query: 320  EARAERERARAEVGRAAQLL 339
            EAR  +  A   V R  + L
Sbjct: 2581 EARRRQHEAEEGVRRKQEEL 2600



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)

Query: 151  EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
            EE+L   Q A+     ERERL         ++ L+E     + Q E E   LQ    ++ 
Sbjct: 1374 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1425

Query: 201  GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
              +     AA   +QQ  + + E ++LRQ  +E E QA +      E+  L   + +   
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1484

Query: 259  --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
              QLEA  + +   + E+Q L+++        R+A E AER   Q + +    R AE+E 
Sbjct: 1485 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1544

Query: 309  ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
                             L+A+E   L+   AER   +AEV RA Q+
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1590



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)

Query: 209  AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
            AA +  ++L+A+  EA RLR+R  +       L  +AA +     EK      Q  EQ L
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2092

Query: 261  EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
            +  +Q +   +  L+ +    R A E AE       RE  Q  ++V++ E      E Q 
Sbjct: 2093 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152

Query: 312  RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
            +A  ++   A   R+ A  E  R AQ    +L
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)

Query: 167  ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
            E ERLK+   E +    Q +A    L+    + A    +A  AA + +Q  +A+  + ++
Sbjct: 2140 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2199

Query: 227  LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
              ++    +AQ   E+T                            E   Q   +E+    
Sbjct: 2200 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2259

Query: 264  VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
            V+ + +E+  LK++      AL   +++ TQ+ +Q+   +  ++  +   +  + +EA  
Sbjct: 2260 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2319

Query: 324  ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
             R+ A  ++ +   L +  L E  +  +   RL AEA
Sbjct: 2320 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2356



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)

Query: 110  KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
            +E ARL RE +    +       LA  +     L+++    EE        ++   +E+ 
Sbjct: 1761 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1812

Query: 170  RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
            + +     G   E+  EA          K    L E +AA    RQ+ EA+R  AE+L  
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1868

Query: 230  RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
                   +  +E+    EKE        E+L  L + +  + + L+ Q    +  +E   
Sbjct: 1869 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922

Query: 287  -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
                 A++ E  +QK  V+D   +  ++E ++ A++ S E+A A +     E+GR
Sbjct: 1923 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)

Query: 94   ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
            A  + L + AE   E  +  RL  + +Q   ++      L   +   S L    G  E+ 
Sbjct: 1888 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1943

Query: 154  LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
            L + +  +     E   LK    + + G+ + E E   ++ +      +  +A   AA+ 
Sbjct: 1944 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999

Query: 214  RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
            RQ   + E +R EAE              R R+   E       + + A  +    E+E 
Sbjct: 2000 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059

Query: 251  -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
                 L Q  + ++L+A        VQ K+QE+       Q++  Q  G  EA   A  E
Sbjct: 2060 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2119

Query: 292  ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
              + +VQ  E   A+   Q+   ER L+++  E+ +ARA+   AA+ L        E  +
Sbjct: 2120 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2171

Query: 352  GLARLAEA 359
              AR A+A
Sbjct: 2172 EAARRAQA 2179



 Score = 32.7 bits (73), Expect = 0.52
 Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)

Query: 103  AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
            A+  ++V+EA RL ++ +++  +  + A   A      +   +A     E+  L + Q+A
Sbjct: 2132 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190

Query: 161  DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
            DA    E E+ KK   +    + Q E E   L+              +   +L     EA
Sbjct: 2191 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2246

Query: 207  NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
                +Q  ++L + R + E L +  A +EA+  + +      T    +E   + + + + 
Sbjct: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306

Query: 261  EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
             A +    QE   ++ L  +    + AL     +E  Q VQ+     AE E   +  E +
Sbjct: 2307 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2366

Query: 318  LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
             E+AR    R + +  + AQ       +L+E  +G  R  EA
Sbjct: 2367 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2397



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)

Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
           EE Q +V       DL +  A+L    R + +S+EE RA+ ERAR++ G+
Sbjct: 560 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 608


>gi|7706687 Enah/Vasp-like [Homo sapiens]
          Length = 418

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 29/103 (28%), Positives = 55/103 (53%), Gaps = 8/103 (7%)

Query: 6   EQPIFSTRAHVFQIDPATKRNWIPA--GKHALT-VSYFYDATRNVYRIISIG--GAKAII 60
           EQ I   RA V   D  +K+ W+P   G+   + ++ +++   N +R++ +     + +I
Sbjct: 5   EQSICQARASVMVYDDTSKK-WVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVI 63

Query: 61  NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFA 103
           N ++   + + + +  F QW D+R   VYGL FAS++  T F+
Sbjct: 64  NYSIVKGLKYNQATPTFHQWRDAR--QVYGLNFASKEEATTFS 104


>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
          Length = 1476

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 63/241 (26%), Positives = 107/241 (44%), Gaps = 48/241 (19%)

Query: 162 APGPTERERLKKMLSE-----GSVGEVQWEAEFFALQDSNN---KLAGALREANAAAAQW 213
           A G  E+E L++ +++      ++G+ + EA+   L+  N    +L+  L +A  A A+ 
Sbjct: 721 ASGVAEQEALREEVAQLRRKAEALGD-ELEAQARKLEAQNTEAARLSKELAQARRAEAEA 779

Query: 214 RQQLEAQRAEAERLRQRV---------AELEAQAASEVTPTGEKEGLGQGQSLEQLEALV 264
            ++ EAQ  E  RLR+ V         A  E +A  E      +E     +   +L A  
Sbjct: 780 HREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839

Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLE-----TRNAELEHQLRAMERSLE 319
           +  ++ +Q L+S+    R+ LE AERE  +++    E      R  EL  +L  ++R LE
Sbjct: 840 EAAEERMQVLESEG---RQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELE 896

Query: 320 EARAER------------------ERARAEVGRAAQLLDVSLFELS----ELREGLARLA 357
           +A  ER                  +R  AE+  AA   + +L EL     +L E L +L 
Sbjct: 897 QAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLR 956

Query: 358 E 358
           +
Sbjct: 957 Q 957



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 60/257 (23%), Positives = 104/257 (40%), Gaps = 35/257 (13%)

Query: 100  TQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQS 159
            TQ     +  +  A L  EK+   G+L          Q     L S  G  +E L +SQ 
Sbjct: 975  TQNVRLIEVERSNAMLVAEKAALQGQL----------QHLEGQLGSLQGRAQELLLQSQR 1024

Query: 160  ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEA 219
            A       +E   ++ +E SV E+Q +     L+    ++  A +       Q +  L  
Sbjct: 1025 A-------QEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRD 1077

Query: 220  QRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG 279
             +A A+  R++ AELE            ++     ++LE     +Q + +++Q  ++   
Sbjct: 1078 HKALAQLQRRQEAELEGLLVR------HRDLKANMRALELAHRELQGRHEQLQAQRASV- 1130

Query: 280  GPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLL 339
               EA E A   E ++ +QD         H+ R +E  L   ++E +RA+  +   ++  
Sbjct: 1131 ---EAQEVALLAERERLMQD--------GHRQRGLEEELRRLQSEHDRAQMLLAELSRER 1179

Query: 340  DVSLFELSELREGLARL 356
                 E  ELR  LARL
Sbjct: 1180 GELQGERGELRGRLARL 1196



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 49/181 (27%), Positives = 82/181 (45%), Gaps = 26/181 (14%)

Query: 176 SEGSVGEVQWE--------AEFFALQDS-NNKLAGALREANAAAAQWRQQ---LEAQRAE 223
           SEG++    WE        A   A Q++   ++A   R+A A   +   Q   LEAQ  E
Sbjct: 702 SEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTE 761

Query: 224 AERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPRE 283
           A RL + +A+     A        +E   Q     +L   V+   QE+++   +     E
Sbjct: 762 AARLSKELAQARRAEAE-----AHREAEAQAWEQARLREAVEAAGQELESASQEREALVE 816

Query: 284 ALEAA--EREETQQKVQDLETRNAELEHQLRAME----RSLEEA---RAERERARAEVGR 334
           AL AA  ER + +++   L  ++   E +++ +E    + LEEA   R E+E  +AE+ +
Sbjct: 817 ALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEK 876

Query: 335 A 335
           A
Sbjct: 877 A 877



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 14/243 (5%)

Query: 97   QHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFR 156
            QHL + AE+ +  KEA +   EK+   G+     L     ++  + L       E++   
Sbjct: 855  QHLEE-AERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKE--- 910

Query: 157  SQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQ 216
            SQ     G  +R   +   +  S  E   E +  ALQ         LR+  A     +++
Sbjct: 911  SQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQ--LRQGPAGLGP-KKR 967

Query: 217  LEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGL-GQGQSLEQLEALVQTKDQEIQTLK 275
             E Q  E + +R  + E+E   A  V    EK  L GQ Q LE     +Q + QE+  L+
Sbjct: 968  AEPQLVETQNVR--LIEVERSNAMLVA---EKAALQGQLQHLEGQLGSLQGRAQEL-LLQ 1021

Query: 276  SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRA 335
            SQ      +   AE+   + + Q+L  +   LE ++RA  +S EE R +++    +    
Sbjct: 1022 SQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKAL 1081

Query: 336  AQL 338
            AQL
Sbjct: 1082 AQL 1084



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 57/230 (24%), Positives = 94/230 (40%), Gaps = 17/230 (7%)

Query: 113 ARLAREK---SQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
           ++LARE+   +Q   EL      L      PS    A GP      +  +A A    +  
Sbjct: 214 SKLARERDLGAQRLAELLLEREPLCLRPEAPSR-APAEGPSHHLALQLANAKA----QLR 268

Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
           RL++ L E +   +  +AE   L+    +L    +EA A + Q  ++ E  R EAE LR+
Sbjct: 269 RLRQELEEKAELLLDSQAEVQGLEAEIRRLR---QEAQALSGQ-AKRAELYREEAEALRE 324

Query: 230 RVAELEAQAASEVTPTGEKEGLGQG--QSLEQLEALVQTKDQEIQTLKSQTGGPREALEA 287
           R   L  +   E+    E+    +     LE+   L    +     L+ Q    RE    
Sbjct: 325 RAGRL-PRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARE--RC 381

Query: 288 AEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 337
           A   ETQ++   L TR  E   +L ++   +++   E      E+ R+ +
Sbjct: 382 ARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLE 431



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 32/136 (23%), Positives = 50/136 (36%), Gaps = 29/136 (21%)

Query: 247 EKEGLGQGQSLEQLEALVQTKDQ----------------------EIQTLKSQTGGPREA 284
           E+EG  QG  L   +A  +  DQ                      E+Q  +    G   A
Sbjct: 662 EQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLA 721

Query: 285 LEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQL------ 338
              AE+E  +++V  L  +   L  +L A  R LE    E  R   E+ +A +       
Sbjct: 722 SGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHR 781

Query: 339 -LDVSLFELSELREGL 353
             +   +E + LRE +
Sbjct: 782 EAEAQAWEQARLREAV 797


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.124    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,447,330
Number of Sequences: 37866
Number of extensions: 551269
Number of successful extensions: 6121
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 255
Number of HSP's successfully gapped in prelim test: 600
Number of HSP's that attempted gapping in prelim test: 3476
Number of HSP's gapped (non-prelim): 2352
length of query: 361
length of database: 18,247,518
effective HSP length: 104
effective length of query: 257
effective length of database: 14,309,454
effective search space: 3677529678
effective search space used: 3677529678
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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