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Search of human proteins with 224809410
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2
[Homo sapiens]
(358 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2 [... 691 0.0
gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1 [... 686 0.0
gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1 [... 686 0.0
gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3 [... 600 e-172
gi|4759198 homer 1 [Homo sapiens] 321 7e-88
gi|46249351 homer 2 isoform 2 [Homo sapiens] 293 1e-79
gi|46249349 homer 2 isoform 1 [Homo sapiens] 289 2e-78
gi|110349797 homer 2 isoform 4 [Homo sapiens] 241 6e-64
gi|110349794 homer 2 isoform 3 [Homo sapiens] 237 1e-62
gi|56549694 enabled homolog isoform a [Homo sapiens] 80 3e-15
gi|39930375 enabled homolog isoform b [Homo sapiens] 80 3e-15
gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens] 60 3e-09
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 59 7e-09
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 55 7e-08
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 55 7e-08
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 53 4e-07
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 53 5e-07
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 52 6e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 52 6e-07
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 52 6e-07
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 52 8e-07
gi|7706687 Enah/Vasp-like [Homo sapiens] 52 1e-06
gi|14149742 coiled-coil transcriptional coactivator isoform 1 [H... 51 1e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 50 2e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 50 2e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 50 2e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 50 2e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 50 2e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 50 2e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 50 2e-06
>gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2
[Homo sapiens]
Length = 358
Score = 691 bits (1784), Expect = 0.0
Identities = 358/358 (100%), Positives = 358/358 (100%)
Query: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
Query: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS
Sbjct: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTR 300
EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTR
Sbjct: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTR 300
Query: 301 NAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAAP 358
NAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAAP
Sbjct: 301 NAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAAP 358
>gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
Length = 361
Score = 686 bits (1770), Expect = 0.0
Identities = 358/361 (99%), Positives = 358/361 (99%), Gaps = 3/361 (0%)
Query: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
Query: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS
Sbjct: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQ-- 298
EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQ
Sbjct: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
Query: 299 -TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 357
TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
Query: 358 P 358
P
Sbjct: 361 P 361
>gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
Length = 361
Score = 686 bits (1770), Expect = 0.0
Identities = 358/361 (99%), Positives = 358/361 (99%), Gaps = 3/361 (0%)
Query: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
Query: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS
Sbjct: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQ-- 298
EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQ
Sbjct: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
Query: 299 -TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 357
TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
Query: 358 P 358
P
Sbjct: 361 P 361
>gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3
[Homo sapiens]
Length = 325
Score = 600 bits (1546), Expect = e-172
Identities = 322/361 (89%), Positives = 322/361 (89%), Gaps = 39/361 (10%)
Query: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
Query: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQ
Sbjct: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQ------------------- 101
Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
VPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 102 -----------------VPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 144
Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 145 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 204
Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQ-- 298
EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQ
Sbjct: 205 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 264
Query: 299 -TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 357
TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 265 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 324
Query: 358 P 358
P
Sbjct: 325 P 325
>gi|4759198 homer 1 [Homo sapiens]
Length = 354
Score = 321 bits (822), Expect = 7e-88
Identities = 182/357 (50%), Positives = 236/357 (66%), Gaps = 10/357 (2%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
EQPIFSTRAHVFQIDP TK+NW+P KHA+TVSYFYD+TRNVYRIIS+ G+KAIINST+T
Sbjct: 3 EQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTIT 62
Query: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
PNMTFTKTSQKFGQWADSRANTVYGLGF+SE HL++FAEKFQE KEAARLA+EKSQ+ E
Sbjct: 63 PNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKME 122
Query: 126 LTSPALGLASHQVPPSPLV--SANGPGEEKL--FRSQSADAPGPTERERLKKMLSEGSVG 181
LTS ++ SPL S NG +E+ S PT+ S S
Sbjct: 123 LTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQN---ALPFSHSSAI 179
Query: 182 EVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE 241
WEAE L+ +N KL AL E+ A QW+QQL A + EAERL +RV ELE ++
Sbjct: 180 SKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQA 239
Query: 242 VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAER-EETQQKVQTR 300
K L Q++++LE ++ K++EI+ LK + RE E + + Q+V+ R
Sbjct: 240 NAVHTHKTEL--NQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIR 297
Query: 301 NAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 357
N +LE QL +E+ LE+++ E+E R + ++LD +FEL+ELR+ LA+L E +
Sbjct: 298 NKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS 354
>gi|46249351 homer 2 isoform 2 [Homo sapiens]
Length = 354
Score = 293 bits (751), Expect = 1e-79
Identities = 160/350 (45%), Positives = 232/350 (66%), Gaps = 4/350 (1%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
Query: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
Query: 126 LTSPALGLASHQVPPSPLVSA-NGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQ 184
+S + + P S S+ NG +EK + A+ +E ++LK L++ + +
Sbjct: 123 TSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKK 182
Query: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
WE E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 183 WEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINR 241
Query: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG-GPREALEAAEREETQQKVQTRNAE 303
EK + +E+LEA ++ K+ E++ L+ Q+ P+ E E + + N
Sbjct: 242 EKEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 300
Query: 304 LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 353
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 301 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 350
>gi|46249349 homer 2 isoform 1 [Homo sapiens]
Length = 343
Score = 289 bits (740), Expect = 2e-78
Identities = 160/349 (45%), Positives = 230/349 (65%), Gaps = 13/349 (3%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
Query: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
Query: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
+S +H S S NG +EK + A+ +E ++LK L++ + +W
Sbjct: 123 TSS------NH----SQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKW 172
Query: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
E E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 173 EIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINRE 231
Query: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG-GPREALEAAEREETQQKVQTRNAEL 304
EK + +E+LEA ++ K+ E++ L+ Q+ P+ E E + + N L
Sbjct: 232 KEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNL 290
Query: 305 EHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 353
E ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 291 EDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 339
>gi|110349797 homer 2 isoform 4 [Homo sapiens]
Length = 299
Score = 241 bits (616), Expect = 6e-64
Identities = 145/349 (41%), Positives = 206/349 (59%), Gaps = 57/349 (16%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
Query: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
Query: 126 LTSPALGLASHQVPPSPLVSA-NGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQ 184
+S + + P S S+ NG +EK A GP
Sbjct: 123 TSSNHSQESGRETPSSTQASSVNGTDDEK------ASHAGPANTH--------------- 161
Query: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
L+ N+KL AL + +AA + ++ ++ + +L++R+ ELEA+ + T
Sbjct: 162 -------LKSENDKLKIALTQ---SAANVKNEINREKEKNTQLKRRIEELEAELREKETE 211
Query: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAEL 304
+ ++ + + I L S+ E LEAAER+ N L
Sbjct: 212 LKD----------------LRKQSEIIPQLMSECEYVSEKLEAAERD---------NQNL 246
Query: 305 EHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 353
E ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 247 EDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 295
>gi|110349794 homer 2 isoform 3 [Homo sapiens]
Length = 288
Score = 237 bits (605), Expect = 1e-62
Identities = 145/348 (41%), Positives = 204/348 (58%), Gaps = 66/348 (18%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
Query: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
Query: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
+S +H S S NG +EK A GP
Sbjct: 123 TSS------NH----SQASSVNGTDDEK------ASHAGPANTH---------------- 150
Query: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
L+ N+KL AL + +AA + ++ ++ + +L++R+ ELEA+ + T
Sbjct: 151 ------LKSENDKLKIALTQ---SAANVKNEINREKEKNTQLKRRIEELEAELREKETEL 201
Query: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELE 305
+ ++ + + I L S+ E LEAAER+ N LE
Sbjct: 202 KD----------------LRKQSEIIPQLMSECEYVSEKLEAAERD---------NQNLE 236
Query: 306 HQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 353
++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 237 DKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 284
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 80.1 bits (196), Expect = 3e-15
Identities = 88/336 (26%), Positives = 126/336 (37%), Gaps = 77/336 (22%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHA--LTVSYFYDATRNVYRIIS--IGGAKAIIN 61
EQ I RA V D A K+ W+PAG V ++ N +R++ I + +IN
Sbjct: 3 EQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVIN 61
Query: 62 STVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQ 121
+ + + + +Q F QW D+R VYGL F S++ FA E SQ
Sbjct: 62 CAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEVL-----NSQ 114
Query: 122 DGGELTSPALGLASHQVPPSPLVSANGPGEEKL----FRSQSADAPGPTERERLKKMLSE 177
+ T P L + Q+P NGP +E+L + Q ERERL+
Sbjct: 115 E----TGPTLPRQNSQLPAQ---VQNGPSQEELEIQRRQLQEQQRQKELERERLE----- 162
Query: 178 GSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQ 237
RE R++LE +R E ERL Q E E Q
Sbjct: 163 --------------------------RERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 238 AASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKV 297
+E L + + LE+ E L + ER+E Q++
Sbjct: 197 ERERQERLERQERLERQERLERQERLDR-----------------------ERQERQERE 233
Query: 298 QTRNAELEHQLRAMERSLEEARAERERARAEVGRAA 333
+ E E Q R + LE + E ER R AA
Sbjct: 234 RLERLERERQERERQEQLEREQLEWERERRISSAAA 269
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 80.1 bits (196), Expect = 3e-15
Identities = 88/336 (26%), Positives = 126/336 (37%), Gaps = 77/336 (22%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHA--LTVSYFYDATRNVYRIIS--IGGAKAIIN 61
EQ I RA V D A K+ W+PAG V ++ N +R++ I + +IN
Sbjct: 3 EQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVIN 61
Query: 62 STVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQ 121
+ + + + +Q F QW D+R VYGL F S++ FA E SQ
Sbjct: 62 CAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEVL-----NSQ 114
Query: 122 DGGELTSPALGLASHQVPPSPLVSANGPGEEKL----FRSQSADAPGPTERERLKKMLSE 177
+ T P L + Q+P NGP +E+L + Q ERERL+
Sbjct: 115 E----TGPTLPRQNSQLPAQ---VQNGPSQEELEIQRRQLQEQQRQKELERERLE----- 162
Query: 178 GSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQ 237
RE R++LE +R E ERL Q E E Q
Sbjct: 163 --------------------------RERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 238 AASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKV 297
+E L + + LE+ E L + ER+E Q++
Sbjct: 197 ERERQERLERQERLERQERLERQERLDR-----------------------ERQERQERE 233
Query: 298 QTRNAELEHQLRAMERSLEEARAERERARAEVGRAA 333
+ E E Q R + LE + E ER R AA
Sbjct: 234 RLERLERERQERERQEQLEREQLEWERERRISSAAA 269
>gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]
Length = 380
Score = 60.1 bits (144), Expect = 3e-09
Identities = 79/371 (21%), Positives = 135/371 (36%), Gaps = 54/371 (14%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALT---VSYFYDATRNVYRIISIG---GAKAI 59
E I S+RA V D KR W+PAG V +++ T N +R++ + +
Sbjct: 3 ETVICSSRATVMLYDDGNKR-WLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVV 61
Query: 60 INSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFA---------------- 103
IN + + + + + F QW D+R V+GL F S++ QFA
Sbjct: 62 INCAIVRGVKYNQATPNFHQWRDAR--QVWGLNFGSKEDAAQFAAGMASALEALEGGGPP 119
Query: 104 ---------------------EKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSP 142
+K Q+ + + R S GG PA G PP P
Sbjct: 120 PPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPPPP 179
Query: 143 LVSANGPG--EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLA 200
PG + + GP L G G A A + KL
Sbjct: 180 PGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQGPGGGGA---GAPGLAAAIAGAKLR 236
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQL 260
++ A+ + E+ R+ L + + + A+ + T GEK + + E+
Sbjct: 237 KVSKQEEASGGPTAPKAESGRSGGGGLMEEMNAMLAR-RRKATQVGEKTPKDESANQEEP 295
Query: 261 EALVQTKDQEIQT--LKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEA 318
EA V + + ++ K+ T PR ++ Q +++ R + LEE
Sbjct: 296 EARVPAQSESVRRPWEKNSTTLPRMKSSSSVTTSETQPCTPSSSDYSDLQRVKQELLEEV 355
Query: 319 RAERERARAEV 329
+ E ++ + E+
Sbjct: 356 KKELQKVKEEI 366
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 58.9 bits (141), Expect = 7e-09
Identities = 63/240 (26%), Positives = 93/240 (38%), Gaps = 8/240 (3%)
Query: 96 EQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLF 155
EQ + + K QE A RE Q E+ + L + L +GP
Sbjct: 423 EQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAG--- 479
Query: 156 RSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ 215
S D+ E +RL + L+EG G E E Q +L L+EA A
Sbjct: 480 -SPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATAS 538
Query: 216 QLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
Q A ++ E R ELEAQ +S + +G + + E +A E +
Sbjct: 539 QTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMG 598
Query: 276 SQTGGPREAL----EAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGR 331
GGP+EA AA RE+ +Q R + E L ++ E+ER AE+ +
Sbjct: 599 PPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQ 658
Score = 38.1 bits (87), Expect = 0.012
Identities = 57/204 (27%), Positives = 96/204 (47%), Gaps = 36/204 (17%)
Query: 177 EGSVGEVQWEAEFFALQDS-----NNKLAGA------LREANAAAAQWRQQLEAQRAEAE 225
EG E Q E AL++ +++ +G L+E N ++ +++LEA+ A+ +
Sbjct: 601 EGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQ 660
Query: 226 RLRQRV--------AELEAQAASEVT-PTGEKEGLGQGQSL-----EQLEAL--VQTKDQ 269
+QR+ + EAQ A ++ EK G Q+L E+LE+L V T+
Sbjct: 661 ESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTL 720
Query: 270 EIQTLKSQTGGPR-EALEAAEREETQQKVQTRNAELEHQLRAMER--SLEEARAERERAR 326
+ L Q R + +EA+ R E Q ++ AE+ + ER ++EA+ + ER
Sbjct: 721 PARPLDHQWKARRLQKMEASARLELQSALE---AEIRAKQGLQERLTQVQEAQLQAERRL 777
Query: 327 AEVGRAAQLLDVSLFELSELREGL 350
E + +Q L EL+ LRE L
Sbjct: 778 QEAEKQSQALQQ---ELAMLREEL 798
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 55.5 bits (132), Expect = 7e-08
Identities = 51/203 (25%), Positives = 92/203 (45%), Gaps = 30/203 (14%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNK----------LA 200
EE+L R Q + E+ +K+ + E Q +AE ++ + L
Sbjct: 344 EEELLRLQQL------QEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS-------EVTPTGEKEGLGQ 253
G LREA A A + ++E + EA R RQR+ ELE EV ++E +
Sbjct: 398 GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRI 457
Query: 254 GQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMER 313
Q+ L++ ++++++ L +E A++E ++++Q A+ L+ ++
Sbjct: 458 AQT-----RLLEEEEEKLKQLMQLKEEQERYIERAQQE--KEELQQEMAQQSRSLQQAQQ 510
Query: 314 SLEEARAERERARAEVGRAAQLL 336
LEE R R+RA +V A + L
Sbjct: 511 QLEEVRQNRQRADEDVEAAQRKL 533
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 55.5 bits (132), Expect = 7e-08
Identities = 68/281 (24%), Positives = 116/281 (41%), Gaps = 25/281 (8%)
Query: 82 DSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPS 141
D + GL A + L + + +++KE ++ G S A G P
Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL 1122
Query: 142 PLVSANGPGEEKLFRSQSADAPG---PTERERLKKMLSEGSVGEVQWEAEFFA--LQDSN 196
+ A E+ + Q A E ER + + ++ +Q + E A L S
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQ 1182
Query: 197 NKLAGALREANA----------AAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTG 246
+ LA A RE A A +W+ Q+ R EAER ++ LE + +
Sbjct: 1183 SALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVL 1242
Query: 247 EKEGLGQGQSLEQLEALVQTKDQEIQ----TLKSQTGGPREALEAAEREET-QQKVQTRN 301
EKE G+ + L++L K Q+++ L+++T + AAER +++VQ+
Sbjct: 1243 EKE--GESKELKRLVMAESEKSQKLEERLRLLQAETAS--NSARAAERSSALREEVQSLR 1298
Query: 302 AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFE 342
E E Q A E +E ++ ERA E+G+ + F+
Sbjct: 1299 EEAEKQRVASENLRQELTSQAERAE-ELGQELKAWQEKFFQ 1338
Score = 52.4 bits (124), Expect = 6e-07
Identities = 67/269 (24%), Positives = 107/269 (39%), Gaps = 23/269 (8%)
Query: 90 GLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGP 149
GL EQ + +K Q++KE A QD + + A +
Sbjct: 548 GLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRER-------- 599
Query: 150 GEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAA 209
+ L + ++ + + E L++ L + + Q +L+ + E A
Sbjct: 600 -DAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQAC 658
Query: 210 AAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQ--GQSLEQLEALVQTK 267
+E R E + +VAELE Q SE EKE + Q Q EQL+AL ++
Sbjct: 659 -------VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESL 711
Query: 268 DQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARA 327
+L+ + +ALE +R ++ K +TR+ +H+ E LEE RA R+ A
Sbjct: 712 KVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKE--LEEERAGRKGLEA 769
Query: 328 EVGRAAQLLDVSLFELSELREGLARLAEA 356
R QL + E LR LA A
Sbjct: 770 ---RLQQLGEAHQAETEVLRRELAEAMAA 795
Score = 47.8 bits (112), Expect = 2e-05
Identities = 67/292 (22%), Positives = 112/292 (38%), Gaps = 50/292 (17%)
Query: 95 SEQHLTQFAEKFQE----VKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPG 150
S+Q Q+ FQE +KE AR++ Q+ E + G+ SH
Sbjct: 820 SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA---GIESHS------------- 863
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
E ++ R Q+ A R + + E V + + LQ+ K+A +E
Sbjct: 864 ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE---KMAATSKEVARLE 920
Query: 211 AQWRQQLEAQRAEAERLRQRVAE--------LEAQAASEVTPTG------EKEGLGQGQS 256
R+ E Q + L + A LE Q + T E+E G
Sbjct: 921 TLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNE 980
Query: 257 LEQLEALVQT-----------KDQEIQTLKSQTGGPRE--ALEAAEREETQQKVQTRNAE 303
LE+L A + +++E+ L + G + ALE A R E + ++Q E
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040
Query: 304 LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 355
+ ++ +L A E+E E+ + L + EL ELR+ + +L E
Sbjct: 1041 QRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKE 1092
Score = 43.1 bits (100), Expect = 4e-04
Identities = 62/212 (29%), Positives = 87/212 (41%), Gaps = 27/212 (12%)
Query: 167 ERERLKKMLSEGSVGEV--QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLE----AQ 220
ER R M S+G E Q E E L + L AA A+ +L+ Q
Sbjct: 982 ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
Query: 221 RAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQT----KDQEIQTLKS 276
R E L++ +A + + + GL Q +++LE L QT K+Q + K
Sbjct: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ-IKELEELRQTVKQLKEQLAKKEKE 1100
Query: 277 QTGGPREALEAAEREE-TQQKVQTRNAEL----------EHQLRAMERSLEEARAERERA 325
G EAA R E T K++ AE+ + Q ++ERSLE RA +
Sbjct: 1101 HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERA----S 1156
Query: 326 RAEVGRAAQLLDVSLFE-LSELREGLARLAEA 356
RAE A + L L E EL + LA A
Sbjct: 1157 RAERDSALETLQGQLEEKAQELGHSQSALASA 1188
Score = 42.7 bits (99), Expect = 5e-04
Identities = 45/176 (25%), Positives = 79/176 (44%), Gaps = 19/176 (10%)
Query: 176 SEGSVGEVQWEAEFFA--LQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLR--QRV 231
+E + EVQ EA+ A L+ K GA + +++++ + A+ E+L QR
Sbjct: 1487 AETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
Query: 232 AELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAERE 291
+ + S+ ++ Q Q L+ ++A QE Q L++Q + L E+
Sbjct: 1547 QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
Query: 292 ETQQKVQT------------RNAELEHQLRAME---RSLEEARAERERARAEVGRA 332
K+Q +N EL+ QLR++E + +E RAE ER E+ +A
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQA 1662
Score = 37.7 bits (86), Expect = 0.016
Identities = 45/185 (24%), Positives = 75/185 (40%), Gaps = 13/185 (7%)
Query: 184 QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVT 243
Q + + L + N L+ LRE + Q + L E + Q E +AQ E++
Sbjct: 308 QMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELS 367
Query: 244 PT-------GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQK 296
EK + QG+ + E L Q +D Q K + G LE ++E
Sbjct: 368 AALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQE-KGEVLGDVLQLETLKQEAATLA 426
Query: 297 VQTRNAELEHQLRAMERSLEEAR--AERERARAEVGRAAQL---LDVSLFELSELREGLA 351
+ ++ ER +EA+ AER E + + L L S+ LS+ +E L
Sbjct: 427 ANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE 486
Query: 352 RLAEA 356
+ ++A
Sbjct: 487 QASQA 491
Score = 36.6 bits (83), Expect = 0.036
Identities = 59/256 (23%), Positives = 104/256 (40%), Gaps = 39/256 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
+EK Q+++E RL + ++ + +V S E++ S++
Sbjct: 1259 SEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ-----SLREEAEKQRVASENLRQ 1313
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKL------AGALREANAAAAQWRQQ 216
++ ER +++ E W+ +FF + + + L AL A QQ
Sbjct: 1314 ELTSQAERAEELGQELKA----WQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ 1369
Query: 217 LEAQRAEAERLRQRVAELEAQAA--------------SEVTPTGEKEGLGQGQSLEQLEA 262
L+A++A AE+ + E QAA E+ P +K Q ++ +QL A
Sbjct: 1370 LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVA-EQERTAQQLRA 1428
Query: 263 LVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQL-RAMERSLEE---A 318
+ +++ LK G L A E ++ LE +L +A E+ ++E
Sbjct: 1429 EKASYAEQLSMLKKAHG-----LLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
Query: 319 RAERERARAEVGRAAQ 334
RA+ E AEV R AQ
Sbjct: 1484 RADAETRLAEVQREAQ 1499
Score = 35.4 bits (80), Expect = 0.079
Identities = 68/302 (22%), Positives = 99/302 (32%), Gaps = 38/302 (12%)
Query: 68 MTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQ-----------FAEKFQEVKEAARLA 116
MT + +K Q V G+ SE +++ A Q+V+E A
Sbjct: 836 MTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRA 895
Query: 117 REKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFR------SQSADAPGPTERER 170
++ + D L + LV G +E R +++ D E+
Sbjct: 896 QKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQ 955
Query: 171 LKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQR 230
+ E E + + +L AL E+ + R Q Q E RL Q
Sbjct: 956 QGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQ---QEREVARLTQE 1012
Query: 231 VAELEAQAASEVTPTGEKEGLGQGQSLEQL-------EALVQT------KDQEIQTLKSQ 277
+A A E E E Q EQ EAL KDQE+ L+
Sbjct: 1013 RGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGL 1072
Query: 278 TGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAE-----RERARAEVGRA 332
+ LE + Q K Q E EH + +S R E E RAEV +
Sbjct: 1073 EAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132
Query: 333 AQ 334
Q
Sbjct: 1133 EQ 1134
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 53.1 bits (126), Expect = 4e-07
Identities = 73/234 (31%), Positives = 102/234 (43%), Gaps = 34/234 (14%)
Query: 144 VSANG---PGEEKLFRSQSADAPGPTERERLKKMLSEGSVG-EVQWEAEFFALQDSNNKL 199
VSA G PG E A PG + L +E S +V+ E L+++ L
Sbjct: 687 VSATGVENPGVE-------ATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEA---L 736
Query: 200 AGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQ 259
REA A + EA AEA RLR+RV E E AS G + +LEQ
Sbjct: 737 RQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGAS---GGGGGDTTQLRAALEQ 793
Query: 260 LEALVQTKDQEIQTLKSQTGGPREA----LEAAE-----REETQQKVQTRNAELEHQLRA 310
++ +D ++ L++ + EA L A E R E Q+ + R E +L
Sbjct: 794 AREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEAR-LEQSRELEV 852
Query: 311 MERSLEEARAERERAR---AEVGRAAQLLDVSLFEL----SELREGLARLAEAA 357
+ L ARA E+ R AE+GRA + + EL E R+GLA L EA+
Sbjct: 853 LREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREAS 906
Score = 39.3 bits (90), Expect = 0.005
Identities = 41/188 (21%), Positives = 70/188 (37%), Gaps = 3/188 (1%)
Query: 150 GEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAA 209
G E+ R + +A E K +E G ++ ++ G + AA
Sbjct: 731 GLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAA 790
Query: 210 AAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQ 269
Q R+ L + + L A L+ AS + E GL + + L Q+++
Sbjct: 791 LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSREL 850
Query: 270 EI---QTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERAR 326
E+ Q ++ G ++ AAE + + R AEL + L E R E R
Sbjct: 851 EVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALR 910
Query: 327 AEVGRAAQ 334
V A++
Sbjct: 911 QSVVPASE 918
Score = 39.3 bits (90), Expect = 0.005
Identities = 64/263 (24%), Positives = 103/263 (39%), Gaps = 30/263 (11%)
Query: 76 KFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLAS 135
+ G+ D+ V L A E+ AE +E EA R + + + L AL L
Sbjct: 873 ELGRARDAAEARVAELPAACEEARQGLAE-LREASEALRQSVVPASEHRRLQEEALELRG 931
Query: 136 HQVPPSPLVSANGPGEEKL---FRSQSADAPGPTERERLKKMLS------EGSVGEV--- 183
V A G +L + + +E ER+ L EG + E+
Sbjct: 932 RAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRR 991
Query: 184 --QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE 241
+ AE F +Q + A A A QQL R EAER RQ A+ AQ A +
Sbjct: 992 HEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQ--AQSRAQEALD 1049
Query: 242 VTPTGE-------KEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQ 294
+ KE ++L++ A + T E++ L+ Q ++ L+ A R+ +
Sbjct: 1050 KAKEKDKKITELSKEVFNLKEALKEQPAALAT--PEVEALRDQVKDLQQQLQEAARDHSS 1107
Query: 295 QKVQTRNAELEHQLRAMERSLEE 317
R+ H L A++ ++E
Sbjct: 1108 VVALYRS----HLLYAIQGQMDE 1126
Score = 34.3 bits (77), Expect = 0.18
Identities = 44/165 (26%), Positives = 66/165 (40%), Gaps = 34/165 (20%)
Query: 205 EANAAAAQWRQQL-----EAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQ 259
E AA Q++ EA R AE R+RV + +L +
Sbjct: 928 ELRGRAASLEQEVVATGKEAARLRAELERERVCSV---------------------ALSE 966
Query: 260 LEALVQTKDQEIQTLKSQTG--GPREALEAAEREETQQKVQTRNAE---LEHQLRAMERS 314
E +V T + L+ Q G R +AE + Q++ +E E QL E+
Sbjct: 967 HERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQ 1026
Query: 315 LEEARAERERARAEVGRAAQLLDVSL---FELSELREGLARLAEA 356
L R E ERAR RA + LD + +++EL + + L EA
Sbjct: 1027 LRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEA 1071
Score = 31.2 bits (69), Expect = 1.5
Identities = 18/80 (22%), Positives = 37/80 (46%)
Query: 269 QEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAE 328
+EI L+ + G + + E+ + +++ ++ A H L + L++ ER+ +
Sbjct: 324 EEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKES 383
Query: 329 VGRAAQLLDVSLFELSELRE 348
+GR + L L L RE
Sbjct: 384 LGREVESLQSRLSLLENERE 403
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 52.8 bits (125), Expect = 5e-07
Identities = 84/318 (26%), Positives = 122/318 (38%), Gaps = 64/318 (20%)
Query: 84 RANTVYGLGFASEQ--HLTQFAEKFQEVKEAARLAREKS--------QDGG----ELTSP 129
++N + L A +Q L Q EK Q +E R R++ QDG EL
Sbjct: 605 KSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERS 664
Query: 130 ALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWE--- 186
L + S L E L R+ E+ + + L++ G V+ E
Sbjct: 665 HRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSM 724
Query: 187 ----AEFFALQDSNNKLAG----------------ALREANAAAAQWRQQLEAQRA---- 222
AE +LQDS +KL+ A E +A Q RQ+ Q A
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR 784
Query: 223 -EAERLRQ----------------RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQ 265
E ERL + RVAE +A + PT E + L QL +
Sbjct: 785 EEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS 844
Query: 266 TKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERA 325
++QE++ + + EALE A RE ++ + +A L QL A ER E R
Sbjct: 845 GREQELEQARREAQRQVEALERAARE--KEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902
Query: 326 RAEVGRAAQLLDVSLFEL 343
R E + L+ SLFE+
Sbjct: 903 RLE----KEALEGSLFEV 916
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/166 (26%), Positives = 72/166 (43%), Gaps = 5/166 (3%)
Query: 192 LQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGL 251
LQ + A RE A AQ + QL QR + E L + AE E + + E+ ++
Sbjct: 995 LQRLQREKEAAWRELEAERAQLQSQL--QREQEELLARLEAEKE-ELSEEIAALQQERDE 1051
Query: 252 GQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQK--VQTRNAELEHQLR 309
G + + + + K+ E L + G R +L E +QK Q+R + +
Sbjct: 1052 GLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVN 1111
Query: 310 AMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 355
A+ L + RA+RE A A + + L +L + R+ R AE
Sbjct: 1112 ALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAE 1157
Score = 43.9 bits (102), Expect = 2e-04
Identities = 50/164 (30%), Positives = 72/164 (43%), Gaps = 19/164 (11%)
Query: 192 LQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGL 251
L+D+ + L L EA + ++ E QR EA LR+ + E G KE
Sbjct: 1166 LEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGE------------GAKERE 1213
Query: 252 GQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAM 311
+S E+L + V+ + E +LK + L A EE + V EL L+ +
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKL--ALLEEARTAVGKEAGELRTGLQEV 1271
Query: 312 ERSLEEARAERERARAEVGRAAQLLDVSLFELS-ELREGLARLA 354
ERS EAR E + E+ R ++LD L EL E RLA
Sbjct: 1272 ERSRLEARRELQ----ELRRQMKMLDSENTRLGRELAELQGRLA 1311
Score = 43.1 bits (100), Expect = 4e-04
Identities = 54/197 (27%), Positives = 86/197 (43%), Gaps = 17/197 (8%)
Query: 164 GPTERERLKKMLSEGSVGEVQWEAEFFAL----QDSNNKLAGALREANAAAAQWRQQLEA 219
G ERE L++ E + E+E +L +D KLA L EA A + +L
Sbjct: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLA-LLEEARTAVGKEAGELRT 1266
Query: 220 QRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG 279
E ER R A E Q + E G+ L +L+ + ++ + + +T
Sbjct: 1267 GLQEVERSRLE-ARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
Query: 280 GPREALEAAE------REE---TQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVG 330
G R+ L E R+E Q+K+Q + E + R + SLEEAR E+ + +
Sbjct: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARG-TEKQQLDHA 1384
Query: 331 RAAQL-LDVSLFELSEL 346
R +L L+ + E +EL
Sbjct: 1385 RGLELKLEAARAEAAEL 1401
Score = 40.8 bits (94), Expect = 0.002
Identities = 63/257 (24%), Positives = 110/257 (42%), Gaps = 25/257 (9%)
Query: 94 ASEQHLTQFAEKFQEVKEAA-----RLAREKSQDGGELTSPALGLASHQVPPSPLVSANG 148
A+E L + +EV +A+ +L ++ GEL LGL+ + L
Sbjct: 1628 ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVD 1687
Query: 149 PGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANA 208
+ ++ S+ ERL G++ +V+ E+E AL+D L AL +++A
Sbjct: 1688 SLQRQVADSEVKAGTLQLTVERLN-----GALAKVE-ESEG-ALRDKVRGLTEALAQSSA 1740
Query: 209 AAAQWRQQ-LEAQRA--EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQ 265
+ R + L Q+A E RQ + E AA + K+ G+ ++ L V
Sbjct: 1741 SLNSTRDKNLHLQKALTACEHDRQVLQE-RLDAARQALSEARKQSSSLGEQVQTLRGEVA 1799
Query: 266 TKDQEIQTLKSQTGGPREALEAAEREE-----TQQKVQTRNAELEHQLRAMERSLEEARA 320
+ + + Q RE L + E T QK+Q L+ +L +++R+L + A
Sbjct: 1800 DLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEA 1859
Query: 321 ERERARAEVGRAAQLLD 337
E+ EV R+A L+
Sbjct: 1860 EKR----EVERSALRLE 1872
Score = 40.0 bits (92), Expect = 0.003
Identities = 56/257 (21%), Positives = 106/257 (41%), Gaps = 18/257 (7%)
Query: 90 GLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVP-PSPLVSANG 148
GL ++ + Q E E R A E +Q GG ++ GL + P P+P
Sbjct: 1402 GLRLSAAEGRAQGLEAELARVEVQRRAAE-AQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460
Query: 149 PGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNK-LAGALREAN 207
P + P+ E S GS A A D + + + GALRE
Sbjct: 1461 PARDAPAEGSGEGLNSPSTLE-----CSPGSQPPSPGPATSPASPDLDPEAVRGALREFL 1515
Query: 208 AAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTK 267
+++ + R + L +++AE+EA+ S + + + +++ + E ++
Sbjct: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQ-----KAVAESEEARRSV 1570
Query: 268 DQEIQTLKSQTGGPREALEAAEREE--TQQKVQTRNAEL---EHQLRAMERSLEEARAER 322
D + ++++ E++ +ERE T +V T L E +LRA + + + +A
Sbjct: 1571 DGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANE 1630
Query: 323 ERARAEVGRAAQLLDVS 339
+ + R ++LD S
Sbjct: 1631 TKLEGDKRRLKEVLDAS 1647
Score = 37.4 bits (85), Expect = 0.021
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 14/165 (8%)
Query: 202 ALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQ--AASEVTPTGEKEGLGQGQSLEQ 259
AL + R + EA + LR+++++ E++ A E + G Q+ E
Sbjct: 527 ALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586
Query: 260 LEALVQTKDQEIQTLKSQTGGPREALEAAERE-----ETQQKVQTRNAELEHQLRAMERS 314
+ VQ + L + +L+ A+++ + ++K+Q EL Q +E
Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646
Query: 315 LEEARAERERARAEVGRAAQLLD-------VSLFELSELREGLAR 352
E+A + R R E+ R+ + L+ V EL E+RE L+R
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSR 691
Score = 35.8 bits (81), Expect = 0.061
Identities = 56/238 (23%), Positives = 95/238 (39%), Gaps = 27/238 (11%)
Query: 132 GLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFA 191
GL+ + P P S+ G G R S + + L + + + A
Sbjct: 486 GLSGQRTPSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA 544
Query: 192 LQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRV---------AELEAQ---AA 239
QD L G LR+ + + R+ LE Q +RLR + A+ E Q +A
Sbjct: 545 SQD----LLGTLRKQLSDSESERRALEEQ---LQRLRDKTDGAMQAHEDAQREVQRLRSA 597
Query: 240 SEVTPTGEKEGLGQGQSLEQLEALVQTKDQE-IQTLKSQTGGPREALEAAEREETQQKVQ 298
+E+ + EK L + Q +A +++E +Q + + R+ LE EE + VQ
Sbjct: 598 NELL-SREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE----EEQEDAVQ 652
Query: 299 TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 356
A + +L R LE+ +R E+ + L + + L+ A +AEA
Sbjct: 653 D-GARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 709
Score = 33.1 bits (74), Expect = 0.39
Identities = 55/223 (24%), Positives = 85/223 (38%), Gaps = 43/223 (19%)
Query: 97 QHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFR 156
Q L + + QE + AA +K QD L LG S Q + L + E R
Sbjct: 1813 QQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLG--SLQRALAQLEAEKREVERSALR 1870
Query: 157 SQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQ 216
+ +R L++ L + +++ + L +L L A
Sbjct: 1871 LEK-------DRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGA---------- 1913
Query: 217 LEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKD----QEIQ 272
E + AEA+R ++ +LEAQ L Q S QLE Q + QE++
Sbjct: 1914 -ELELAEAQR---QIQQLEAQVVV----------LEQSHSPAQLEVDAQQQQLELQQEVE 1959
Query: 273 TLKSQTGGPREALEAAEREETQ------QKVQTRNAELEHQLR 309
L+S LEA ER Q ++V T +L+ +LR
Sbjct: 1960 RLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELR 2002
Score = 32.0 bits (71), Expect = 0.88
Identities = 48/193 (24%), Positives = 73/193 (37%), Gaps = 20/193 (10%)
Query: 169 ERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ-----WRQQLEAQRAE 223
E K+ LSE Q E L +S + A +L+E+ A R L E
Sbjct: 1032 EAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
Query: 224 AERLRQRVAELEAQAASEVTP-TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
ER ++ + Q S V T E L Q E QE++ L+ Q
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRA-----QREEAAAAHAQEVRRLQEQARDLG 1146
Query: 283 EALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFE 342
+ ++ RE EL QLR +E + + R E A+ ++ + + +V E
Sbjct: 1147 KQRDSCLREAE---------ELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE 1197
Query: 343 LSELREGLARLAE 355
ELR L A+
Sbjct: 1198 AGELRRSLGEGAK 1210
Score = 30.8 bits (68), Expect = 2.0
Identities = 54/215 (25%), Positives = 82/215 (38%), Gaps = 27/215 (12%)
Query: 168 RERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA---AQWRQQLEAQRAEA 224
+E+L ++ + S E + E Q L A RE A A A QL A E
Sbjct: 833 QEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREG 892
Query: 225 ERLRQRVAELEAQA-ASEVTPTGEKEGLGQGQSL-EQLEALVQTKDQEIQTLKSQTGGPR 282
L + L + A E + + L Q ++ EQLEA Q +TL + G R
Sbjct: 893 RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLR 952
Query: 283 EALEAAERE-----------------ETQQKVQTRNAELEHQLRAMERSLEEARAERERA 325
+ + A + + E Q ++ + A E L+ ++R E A E E
Sbjct: 953 QQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAE 1012
Query: 326 RAEVGRAAQLLDVSLF-----ELSELREGLARLAE 355
RA++ Q L E EL E +A L +
Sbjct: 1013 RAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 52.4 bits (124), Expect = 6e-07
Identities = 49/191 (25%), Positives = 88/191 (46%), Gaps = 9/191 (4%)
Query: 172 KKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRV 231
+ L EG + +Q A++ ALQ + + G+L A A R + A +R+
Sbjct: 631 RNQLLEGKLQALQ--ADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAK 688
Query: 232 AELEAQAASEVTPTGEKEGLGQ--GQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAE 289
++AQ A + KEG Q + +EQ + L + + +E++ L+SQ + +E
Sbjct: 689 EAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLT 748
Query: 290 REETQQKV----QTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSE 345
E+ QQ V EL QL + LE + E +R +A+V + +L + +
Sbjct: 749 AEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDK 808
Query: 346 LREGLARLAEA 356
++ L+ +AEA
Sbjct: 809 VQSQLS-MAEA 818
Score = 35.0 bits (79), Expect = 0.10
Identities = 36/164 (21%), Positives = 72/164 (43%), Gaps = 10/164 (6%)
Query: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
W A D+ + G + AAQ Q+L + ER R +V E+ Q ++++
Sbjct: 371 WLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQL-- 428
Query: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAEL 304
++ + + Q E A ++ +E+ L+ + G + EA + Q++ +
Sbjct: 429 ---EQLVKELQLKEDARASLERLVKEMAPLQEELSG--KGQEADQLWRRLQELLAHTSSW 483
Query: 305 EHQLRAMERSLEEARAERERARAEV---GRAAQLLDVSLFELSE 345
E +L + R ++ + E+E EV R Q L+ L ++S+
Sbjct: 484 EEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQ 527
Score = 34.3 bits (77), Expect = 0.18
Identities = 47/180 (26%), Positives = 75/180 (41%), Gaps = 30/180 (16%)
Query: 184 QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVT 243
Q E E ALQ+ ++ + EA A+ ++QL + L +V L
Sbjct: 865 QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCAL--------- 915
Query: 244 PTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE------AAEREETQQKV 297
T EK E++E + QE+Q K RE LE E+E Q+K+
Sbjct: 916 -TVEK---------ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKL 965
Query: 298 QTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELS-ELREGLARLAEA 356
+ A L ++ L +A +RA++ A Q L+ F+LS E+ + +RL A
Sbjct: 966 KAAKA-AAGSLPGLQAQLAQA---EQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNA 1021
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 52.4 bits (124), Expect = 6e-07
Identities = 65/276 (23%), Positives = 104/276 (37%), Gaps = 30/276 (10%)
Query: 74 SQKFGQWADSRANTVYGLGFASEQH------LTQFAEKFQEVKEAARLAREKSQDGGELT 127
SQ+ + D + G A E+ T + E ++ E+ + GG+ +
Sbjct: 1749 SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS 1808
Query: 128 SPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV----GEV 183
L G E + + A+ E E ++ +EG GE
Sbjct: 1809 GHEDNLQGEAAAGGDQDPGQSDGAEGI-EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEA 1867
Query: 184 QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVT 243
Q E+E ++ + + A+W Q E++ AEA AE EAQ +E
Sbjct: 1868 QPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPE-----AEKEAQPETESV 1922
Query: 244 PTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQ-------- 295
E EG + +S E EA Q ++ Q + QT E +E+ E EE Q
Sbjct: 1923 EALETEGEDEPES-EGAEA--QEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEA 1979
Query: 296 ---KVQTRNAELEHQLRAMERSLEEARAERERARAE 328
+V+T+ AE E Q + + EA E + A E
Sbjct: 1980 LEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEE 2015
Score = 42.0 bits (97), Expect = 8e-04
Identities = 47/196 (23%), Positives = 82/196 (41%), Gaps = 13/196 (6%)
Query: 151 EEKLFRSQSADAPGPTERERLK----KMLSEGSVGEVQWEAEFFALQDSNNKLAGALREA 206
E ++ SQ A+ E E ++ ++ ++ + GE Q E+E ++ ++ A EA
Sbjct: 1957 ESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEA 2016
Query: 207 NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE----VTPTGEKEGL---GQGQSLEQ 259
+ Q +++ EA+ + + E A E P E+E G+ Q E
Sbjct: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEG 2076
Query: 260 LEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNA-ELEHQLRAMERSLEEA 318
EA +++D + Q + + E +EA E E QK + A E E + + +E
Sbjct: 2077 -EAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAP 2135
Query: 319 RAERERARAEVGRAAQ 334
AE E G AQ
Sbjct: 2136 EAEGEAQPESEGVEAQ 2151
Score = 34.3 bits (77), Expect = 0.18
Identities = 35/117 (29%), Positives = 49/117 (41%), Gaps = 13/117 (11%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
E + +Q A+ E E ++ +EG E Q E+E ++ + L A
Sbjct: 2160 ESEGIEAQEAEEEAQPELEGVEAPEAEG---EAQPESEGIEAPEAEGEAQPELEGVEAPE 2216
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEG-----LGQGQSLEQLEA 262
A+ Q E + E AE EAQ SE GEK+G LG GQS E E+
Sbjct: 2217 AEEEAQPEPEGVETPE-----AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASES 2268
Score = 33.5 bits (75), Expect = 0.30
Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 6/122 (4%)
Query: 234 LEAQAASEVTPTGEKEGLGQGQ----SLEQLEALVQTKDQEIQTLKSQTGGPREALEAAE 289
L A+A + T E E + Q +LEQL ++ +++ K T G EA +
Sbjct: 1262 LNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQ 1321
Query: 290 REE--TQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELR 347
EE T++ +Q +LE +E A+ E G Q V L E+ E
Sbjct: 1322 LEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGP 1381
Query: 348 EG 349
EG
Sbjct: 1382 EG 1383
Score = 33.1 bits (74), Expect = 0.39
Identities = 63/242 (26%), Positives = 94/242 (38%), Gaps = 33/242 (13%)
Query: 108 EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
E++EA A+ +S DG E + G + +V + E S +AP E
Sbjct: 2008 EMQEAEEEAQPES-DGVEAQPKSEGEEAQEVEGETQKTEGDAQPE----SDGVEAPEAEE 2062
Query: 168 RERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAE---- 223
++ + GEVQ EAE A +S + A +EA A + +EA AE
Sbjct: 2063 E-------AQEAEGEVQ-EAEGEAHPESEDVDA---QEAEGEAQPESEGVEAPEAEGEAQ 2111
Query: 224 -AERLRQRVAELEAQAASEVTPTGEKEGLGQGQSL------EQLEALVQTKDQEIQTLKS 276
AE + E EAQ SE E EG Q +S + EA +++ E Q +
Sbjct: 2112 KAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEE 2171
Query: 277 QTGGPREALEAAEREETQQ------KVQTRNAELEHQLRAMERSLEEARAERERARAEVG 330
+ E +EA E E Q + E + +L +E E A+ E E
Sbjct: 2172 EAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETP 2231
Query: 331 RA 332
A
Sbjct: 2232 EA 2233
Score = 30.0 bits (66), Expect = 3.3
Identities = 54/227 (23%), Positives = 84/227 (37%), Gaps = 43/227 (18%)
Query: 107 QEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPT 166
QE+ EA+ + SQ+ + G AS P P P E S++ P +
Sbjct: 1408 QELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSET--DPSAS 1465
Query: 167 ERERLKKMLS--EGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ----WRQQL--E 218
ER+ ++ E G E Q + + A +AA W L +
Sbjct: 1466 ERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKK 1525
Query: 219 AQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQ---------TKDQ 269
++A L VAEL A + GL L+Q+ A +Q + +
Sbjct: 1526 TEKAFLAHLASAVAELRA-----------RWGLQDNDLLDQMAAELQQDVAQRLQDSTKR 1574
Query: 270 EIQTLKSQTG-----GPREALEAAEREETQQKVQTRNAELEHQLRAM 311
E+Q L+ + G PREAL +TQQ+ H+LR +
Sbjct: 1575 ELQKLQGRAGRMVLEPPREALTGELLLQTQQR--------RHRLRGL 1613
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 52.4 bits (124), Expect = 6e-07
Identities = 54/235 (22%), Positives = 104/235 (44%), Gaps = 19/235 (8%)
Query: 131 LGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFF 190
L S +V L+ A + K ++++ + E ER + E E E E
Sbjct: 1136 LSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELE-- 1193
Query: 191 ALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEG 250
+L+ L EA A+A R+ + AE RLR+ + E + + V K+
Sbjct: 1194 -------ELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQA 1246
Query: 251 LGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEA---------AEREETQQKVQTRN 301
G + EQ+++L + + Q+++ KS+ + L A A E+ + + +
Sbjct: 1247 EGAAELGEQVDSLQRVR-QKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305
Query: 302 AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 356
+E + ++ ++R L +A +R R + E G ++LL+ +S+L G A A++
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQS 1360
Score = 45.1 bits (105), Expect = 1e-04
Identities = 66/264 (25%), Positives = 109/264 (41%), Gaps = 32/264 (12%)
Query: 101 QFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSA 160
Q +E +V+E R + S G L + + L+ L+S G+ +S
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEE 1363
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ-----DSNNKLAGALREANAAAAQWRQ 215
E + K L+ +V ++ + + Q ++ +L L +ANA AQWR
Sbjct: 1364 LRRQLEEESKAKSALAH-AVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRS 1422
Query: 216 QLEA---QRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQ 272
+ EA QR E ++ L Q A E G + + SLE+ + +QT+ +++
Sbjct: 1423 KYEADAIQRTEELEEAKKKLALRLQEAEE----GVEAANAKCSSLEKAKLRLQTESEDV- 1477
Query: 273 TLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRA 332
TL+ + A AA A L+ + R +ER+LEE R + E + E+ A
Sbjct: 1478 TLELE-----RATSAA-------------AALDKKQRHLERALEERRRQEEEMQRELEAA 1519
Query: 333 AQLLDVSLFELSELREGLARLAEA 356
+ EL LR G EA
Sbjct: 1520 QRESRGLGTELFRLRHGHEEALEA 1543
Score = 43.9 bits (102), Expect = 2e-04
Identities = 60/260 (23%), Positives = 111/260 (42%), Gaps = 23/260 (8%)
Query: 96 EQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLF 155
E Q E+ +E K+ L +++++G E + +S + L + + +L
Sbjct: 1425 EADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKC--SSLEKAKLRLQTESEDVTLELE 1482
Query: 156 RSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ 215
R+ SA A ++ L++ L E E + + E A Q + L L + +
Sbjct: 1483 RATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALE 1542
Query: 216 QLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
LE + E + L++ +++L Q + G+S+++LE +TK + L+
Sbjct: 1543 ALETLKRENKNLQEEISDLTDQVSLS------------GKSIQELE---KTK----KALE 1583
Query: 276 SQTGGPREALEAAEREETQQKVQTRNAELE-HQLRA-MERSLEEARAERERARAEVGRAA 333
+ + ALE AE ++ +T +LE Q++A ++R L E E R RA
Sbjct: 1584 GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAV 1643
Query: 334 QLLDVSLFELSELREGLARL 353
+ L SL + R RL
Sbjct: 1644 ESLQASLDAETRARNEALRL 1663
Score = 43.1 bits (100), Expect = 4e-04
Identities = 57/237 (24%), Positives = 102/237 (43%), Gaps = 18/237 (7%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ +E EA R AR + + + L S ++ + SA G+ + R + A
Sbjct: 1164 AEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASA---GQREGCRKREA-- 1218
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E RL++ L E ++ + EA AL+ + A L E + + RQ+LE +++
Sbjct: 1219 ----ELGRLRRELEEAAL---RHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKS 1271
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
E LR V +L A + E L + + EA ++ ++ + Q + T R
Sbjct: 1272 E---LRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGR 1328
Query: 283 EALEAAEREETQQKVQTRNAELEHQLRAMERSLEEAR---AERERARAEVGRAAQLL 336
E+ E ++ + ++L +SLEE R E +A++ + A Q L
Sbjct: 1329 LQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQAL 1385
Score = 43.1 bits (100), Expect = 4e-04
Identities = 47/196 (23%), Positives = 84/196 (42%), Gaps = 22/196 (11%)
Query: 150 GEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAA 209
GE+ ++ +A G E E K + + + +V+ E + L + + + A R A
Sbjct: 1584 GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR-KLAEKDEECANLRRNHQRA 1642
Query: 210 AAQWRQQLEAQ---RAEAERLRQRVA----ELEAQAASEVTPTGEKEGLGQGQSLEQLEA 262
+ L+A+ R EA RL++++ +LE Q LG + + EA
Sbjct: 1643 VESLQASLDAETRARNEALRLKKKMEGDLNDLELQ-------------LGHA-TRQATEA 1688
Query: 263 LVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAER 322
T+ + Q + Q G E AAE E Q ++ R + L +L + +LE+ R
Sbjct: 1689 QAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSR 1748
Query: 323 ERARAEVGRAAQLLDV 338
A E+ A + L++
Sbjct: 1749 RLAEQELLEATERLNL 1764
Score = 37.0 bits (84), Expect = 0.027
Identities = 50/188 (26%), Positives = 77/188 (40%), Gaps = 10/188 (5%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFF--ALQDSNNKLAGALREANAAAAQWRQQLEAQRAEA 224
E E+ KK L EG E+Q E AL+ K E + A+ ++L + E
Sbjct: 1574 ELEKTKKAL-EGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEEC 1632
Query: 225 ERLRQR----VAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGG 280
LR+ V L+A +E E L + + + +Q Q ++Q
Sbjct: 1633 ANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAAT 1692
Query: 281 PREALEAAEREETQQKVQTRNAELEHQLRAMER--SLEEARAERERARAEVG-RAAQLLD 337
+ E + + + Q AEL Q +A+ER SL A E RA E G R+ +L +
Sbjct: 1693 RLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAE 1752
Query: 338 VSLFELSE 345
L E +E
Sbjct: 1753 QELLEATE 1760
Score = 35.0 bits (79), Expect = 0.10
Identities = 54/258 (20%), Positives = 112/258 (43%), Gaps = 30/258 (11%)
Query: 99 LTQFAEKFQEVKEAARLAREKSQDGGE----LTSPALGLASHQVP-PSPLVSANGPGEEK 153
L + ++ + + RLA ++ + E L S GL + + + L +G EE
Sbjct: 1734 LEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEA 1793
Query: 154 LFRSQSADAPGPTERERLKKMLSEGSV--GEVQWEAEFFA-LQDSNNKLAGALREANAAA 210
+ A+ E+ KK +++ ++ E++ E + A L+ L +RE A
Sbjct: 1794 AQERREAE-------EKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARL 1846
Query: 211 AQWRQQ-LEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQ 269
+ Q L + + ++L +V ELEA+ +E Q + E L+ V+ ++
Sbjct: 1847 EEAEQAALRGGKKQVQKLEAKVRELEAELDAE-----------QKKHAEALKG-VRKHER 1894
Query: 270 EIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEV 329
++ L Q R+ L A ++ K+Q++ + Q E+ A+ +A+ E+
Sbjct: 1895 RVKELAYQAEEDRKNL--ARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHEL 1952
Query: 330 GRAAQLLDVSLFELSELR 347
A + D++ + ++LR
Sbjct: 1953 DDAEERADMAETQANKLR 1970
Score = 33.9 bits (76), Expect = 0.23
Identities = 41/169 (24%), Positives = 66/169 (39%), Gaps = 31/169 (18%)
Query: 191 ALQDSNNKLAG----------ALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
ALQ+++ + G AL +A Q + LE + ++LR + +
Sbjct: 1047 ALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEG 1106
Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTR 300
++ T E Q +QLE ++ KD E+ L R E +Q + +
Sbjct: 1107 DLKLTQESVA-DAAQDKQQLEEKLKKKDSELSQLSL-------------RVEDEQLLGAQ 1152
Query: 301 NAELEHQLRAMERSLEE-------ARAERERARAEVGRAAQLLDVSLFE 342
+ +L+A LEE ARA E+ RAE R + L L E
Sbjct: 1153 MQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEE 1201
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 52.0 bits (123), Expect = 8e-07
Identities = 56/205 (27%), Positives = 85/205 (41%), Gaps = 29/205 (14%)
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQ 220
+A G ERER ++ + E E +ALQ +L + E Q Q Q
Sbjct: 761 EALGQQERERARQRFQQ------HLEQEQWALQQQRQRLYSEVAEERERLGQ---QAARQ 811
Query: 221 RAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGG 280
RAE E LRQ++ E + + EK G + + Q+E + TLK Q
Sbjct: 812 RAELEELRQQLEESSSALTRALRAEFEK-GREEQERRHQME---------LNTLKQQLEL 861
Query: 281 PREALEAAEREETQQKVQTRNAELEHQLR-AMERSLE---------EARAERERARAEVG 330
R+A EA + + + R EL ++R ++ +E A A+ E +A
Sbjct: 862 ERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 921
Query: 331 RAAQLLDVSLFELSELREGLARLAE 355
R +L D ELSEL + +L E
Sbjct: 922 RIKRLRDKYEAELSELEQSERKLQE 946
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/142 (28%), Positives = 68/142 (47%), Gaps = 19/142 (13%)
Query: 214 RQQLEAQRA--EAERLRQRVAEL---EAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKD 268
+QQLE +R EA R R+ A L E + E+ +KE LE AL + +
Sbjct: 856 KQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEES 915
Query: 269 QEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQL--------------RAMERS 314
++ + + + E +E E++++K+Q R +EL+ QL R ER+
Sbjct: 916 EKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 975
Query: 315 LEEARAERERARAEVGRAAQLL 336
LE+A+A E+ +E AQ++
Sbjct: 976 LEDAQAVNEQLSSERSNLAQVI 997
Score = 37.0 bits (84), Expect = 0.027
Identities = 43/207 (20%), Positives = 82/207 (39%), Gaps = 8/207 (3%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
E+K S+ +A ++ ++ + + Q E E L++ + A RE
Sbjct: 636 EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARRE----- 690
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQE 270
+W + + ++ + +R E++ A + L + + L+ E Q ++
Sbjct: 691 -KWISE-KTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQ 748
Query: 271 IQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAM-ERSLEEARAERERARAEV 329
+ L+ Q +EAL ERE +Q+ Q + + L+ +R E ERER +
Sbjct: 749 AEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQA 808
Query: 330 GRAAQLLDVSLFELSELREGLARLAEA 356
R L+ +L E L R A
Sbjct: 809 ARQRAELEELRQQLEESSSALTRALRA 835
>gi|7706687 Enah/Vasp-like [Homo sapiens]
Length = 418
Score = 51.6 bits (122), Expect = 1e-06
Identities = 29/103 (28%), Positives = 55/103 (53%), Gaps = 8/103 (7%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPA--GKHALT-VSYFYDATRNVYRIISIG--GAKAII 60
EQ I RA V D +K+ W+P G+ + ++ +++ N +R++ + + +I
Sbjct: 5 EQSICQARASVMVYDDTSKK-WVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVI 63
Query: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFA 103
N ++ + + + + F QW D+R VYGL FAS++ T F+
Sbjct: 64 NYSIVKGLKYNQATPTFHQWRDAR--QVYGLNFASKEEATTFS 104
>gi|14149742 coiled-coil transcriptional coactivator isoform 1 [Homo
sapiens]
Length = 691
Score = 51.2 bits (121), Expect = 1e-06
Identities = 55/193 (28%), Positives = 82/193 (42%), Gaps = 38/193 (19%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
E+E+L L E + Q EAE Q N+ L L+EA + W+ E Q A+A+R
Sbjct: 264 EQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKS----WQ---EEQSAQAQR 316
Query: 227 LRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE 286
L+ +VA++ K+ LGQ Q + E++ LK Q G +E
Sbjct: 317 LKDKVAQM-------------KDTLGQAQQ----------RVAELEPLKEQLRGAQELAA 353
Query: 287 AAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQL---LDVSLFEL 343
+ +QQK EL A +R++ E R GR A+L L +
Sbjct: 354 S-----SQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQW 408
Query: 344 SELREGLARLAEA 356
S+ R GL + EA
Sbjct: 409 SKERAGLLQSVEA 421
Score = 32.3 bits (72), Expect = 0.67
Identities = 44/182 (24%), Positives = 79/182 (43%), Gaps = 29/182 (15%)
Query: 197 NKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELE---AQAASEVTP--------- 244
N+L + +E N Q + QLE Q E LR RV ELE A A E T
Sbjct: 151 NQLDESQQERNDLM-QLKLQLEGQVTE---LRSRVQELERALATARQEHTELMEQYKGIS 206
Query: 245 ------TGEKEGLGQGQS-----LEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREET 293
T E++ L + Q + +LE +QT +++ T + + R+ ++A RE
Sbjct: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE-- 264
Query: 294 QQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 353
Q+K+ + E++ E L+ A+ E ++ A + + L++ +A++
Sbjct: 265 QEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQM 324
Query: 354 AE 355
+
Sbjct: 325 KD 326
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 50.4 bits (119), Expect = 2e-06
Identities = 67/290 (23%), Positives = 118/290 (40%), Gaps = 44/290 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL--FRSQSA 160
A+K Q +EA RL R+ + + LAS + + L R Q+
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 161 DAP-----GPTERERLKKMLSEGSV--GEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
+A ER R ++ E + E + +++ + + +L +L+E + A AQ
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 214 RQQLEA---QRAEAERLRQRVA-ELE-------------------------AQAASEVTP 244
R++ E Q+AEAER R+ ELE AQA +E
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 245 T-GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAE 303
E+E +G++ EQ + +QE++ + G + AAE+E + + +T E
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 304 -----LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 348
LE +L ++R A +R+ AE+ + ++V L + E
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Score = 50.1 bits (118), Expect = 3e-06
Identities = 67/254 (26%), Positives = 103/254 (40%), Gaps = 31/254 (12%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1708 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1758
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1759 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1797
Query: 283 EALEAAEREETQQKVQTRNAELEHQLRAMERS-LEEARAERERARAEVGRAAQLLDVSLF 341
E E A R + R +L + A +R+ E AE+ A E R +++L
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857
Query: 342 ELSELREGLARLAE 355
E E L RLAE
Sbjct: 1858 EKEAENERLRRLAE 1871
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 112/260 (43%), Gaps = 27/260 (10%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 266 T----KDQEIQTLK--SQTGGPREAL---EAAEREETQQKVQTRNAELEHQLRAMERSLE 316
+ KD +Q + Q E L E A+ ++ +++ Q + ++E + + + S+E
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 317 EARAERERARAEVGRAAQLL 336
EAR + A V R + L
Sbjct: 2554 EARRRQHEAEEGVRRKQEEL 2573
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/252 (25%), Positives = 102/252 (40%), Gaps = 39/252 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE + K A + R+K+Q ELT+ L L + L +E+L R ++
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEAT 2217
Query: 163 PGPTERERLKKMLSEGSV---------GEVQWEAEFFALQDSNN---------------- 197
+R ++++ L V ++ E L+D +N
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 198 KLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT-GEKEGLGQGQS 256
+ A L A AA+ RQ E A+ L +++ + + QA E T E E L Q +
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 257 L--EQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERS 314
L EQ L + K+Q Q L +T G + LEA + + + + +LR E S
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL----KLRVAEMS 2393
Query: 315 LEEARAERERAR 326
+ARAE + R
Sbjct: 2394 RAQARAEEDAQR 2405
Score = 47.0 bits (110), Expect = 3e-05
Identities = 51/176 (28%), Positives = 83/176 (47%), Gaps = 12/176 (6%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ-QLEAQR---- 221
ER RL+ + E V +Q EA + +L A A AQ RQ Q EA+R
Sbjct: 1444 ERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 222 AEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGP 281
+ E R+R AE+E + + +E Q+LE+L +Q ++ E + +++
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR--LQAEEAERRLRQAEVERA 1560
Query: 282 RE---ALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 334
R+ ALE A+R + ++Q++ A + +ERSL+E + R E R AQ
Sbjct: 1561 RQVQVALETAQR-SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/250 (26%), Positives = 108/250 (43%), Gaps = 32/250 (12%)
Query: 108 EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
+V+EA RL Q+ A A ++ EEK A A E
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQ----------AEEKAH----AFAVQQKE 2062
Query: 168 RERLKKMLSEGSV-GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
+E + + E SV +++ EAE A + + + A +A AAQ R+Q+E EAER
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAEREAAQSRRQVE----EAER 2116
Query: 227 LRQRVAE-----LEAQAASE-VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGG 280
L+Q E +AQAA+E + E+E + Q+ + Q D E++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 281 PREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARA---ERERARAEVGRAAQLLD 337
E+E T ++Q E +HQ ++ L+ +A E R R++V +
Sbjct: 2177 TLRQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 338 VSLFELSELR 347
V + ELS+L+
Sbjct: 2235 VQMEELSKLK 2244
Score = 45.4 bits (106), Expect = 8e-05
Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 13/154 (8%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEK----EGLGQGQSLEQLEALV 264
AA + ++L+A+ EA RLR+R + A+ +K E +++Q E +
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRN--AELEHQLRAMERSLEEARAER 322
Q Q+ Q++ Q G EA A E + +VQ A+ Q+ ER L+++ E+
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQ 2124
Query: 323 ERARAEVGRAAQLLDVSLFELSELREGLARLAEA 356
+ARA+ AA+ L E + AR A+A
Sbjct: 2125 AQARAQAQAAAEKL------RKEAEQEAARRAQA 2152
Score = 43.1 bits (100), Expect = 4e-04
Identities = 51/187 (27%), Positives = 81/187 (43%), Gaps = 41/187 (21%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
EE+L Q A+ ERERL AE A + +LA A +A A A
Sbjct: 1347 EERLAEQQRAE-----ERERL---------------AEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSL-EQLEALVQTKDQ 269
+ ++L+ QR + E +R+ A ++AQ Q +S+ E+L+ L Q+ +
Sbjct: 1387 EREAKELQ-QRMQEEVVRREEAAVDAQQ--------------QKRSIQEELQQLRQSSEA 1431
Query: 270 EIQTLKSQTGGPREALEAAEREETQQKVQTRNAE-----LEHQLRAMERSLEEARAERER 324
EIQ Q + E E ++Q E E +L+A+ EEA A++ +
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 325 ARAEVGR 331
A+ E R
Sbjct: 1492 AQEEAER 1498
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/258 (23%), Positives = 106/258 (41%), Gaps = 25/258 (9%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E +R EKS+ E + + + ++ + +L +A ER
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER-LR 228
+K+ + G ++ EAE AL++ + R A A Q R++LE Q A+ + +
Sbjct: 1835 LAEKLAAIGEATRLKTEAEI-ALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIE 1892
Query: 229 QRVAELEAQAASEVTPTG-------------EKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
+R+A+L + SE+ E+E L S E+ A + E+ ++
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952
Query: 276 SQTGGPREALEAAEREETQQKV-----QTRNAELEHQLRAMERSLEEARAERERARAEVG 330
S + E AE E +Q+ + R E E +++ + EEA +R+ A EV
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 331 RAAQLLDVSLFELSELRE 348
R L + E LRE
Sbjct: 2013 R----LKAKVEEARRLRE 2026
Score = 30.4 bits (67), Expect = 2.6
Identities = 53/246 (21%), Positives = 95/246 (38%), Gaps = 28/246 (11%)
Query: 96 EQHLTQFAEKFQ-EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL 154
EQ + + FQ EV +A +L E+ + ++ L + EE
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-------------EEAR 2556
Query: 155 FRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR---EANAAAA 211
R A+ ++E L+++ E Q + L + N +L L+ E + AA
Sbjct: 2557 RRQHEAEEGVRRKQEELQQL-------EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 212 QWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEI 271
+++ A + A + + A+E P +GL + S ++L+ +E+
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2669
Query: 272 QTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGR 331
Q L G E A RE+ + +Q R++ L+A L A +R G
Sbjct: 2670 QRLAQ---GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL-SVYAALQRQLLSPGT 2725
Query: 332 AAQLLD 337
A LL+
Sbjct: 2726 ALILLE 2731
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 50.4 bits (119), Expect = 2e-06
Identities = 67/290 (23%), Positives = 118/290 (40%), Gaps = 44/290 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL--FRSQSA 160
A+K Q +EA RL R+ + + LAS + + L R Q+
Sbjct: 1491 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1550
Query: 161 DAP-----GPTERERLKKMLSEGSV--GEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
+A ER R ++ E + E + +++ + + +L +L+E + A AQ
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1610
Query: 214 RQQLEA---QRAEAERLRQRVA-ELE-------------------------AQAASEVTP 244
R++ E Q+AEAER R+ ELE AQA +E
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 245 T-GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAE 303
E+E +G++ EQ + +QE++ + G + AAE+E + + +T E
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730
Query: 304 -----LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 348
LE +L ++R A +R+ AE+ + ++V L + E
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780
Score = 50.1 bits (118), Expect = 3e-06
Identities = 67/254 (26%), Positives = 103/254 (40%), Gaps = 31/254 (12%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1712 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1762
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1763 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1801
Query: 283 EALEAAEREETQQKVQTRNAELEHQLRAMERS-LEEARAERERARAEVGRAAQLLDVSLF 341
E E A R + R +L + A +R+ E AE+ A E R +++L
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1861
Query: 342 ELSELREGLARLAE 355
E E L RLAE
Sbjct: 1862 EKEAENERLRRLAE 1875
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 112/260 (43%), Gaps = 27/260 (10%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497
Query: 266 T----KDQEIQTLK--SQTGGPREAL---EAAEREETQQKVQTRNAELEHQLRAMERSLE 316
+ KD +Q + Q E L E A+ ++ +++ Q + ++E + + + S+E
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2557
Query: 317 EARAERERARAEVGRAAQLL 336
EAR + A V R + L
Sbjct: 2558 EARRRQHEAEEGVRRKQEEL 2577
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/252 (25%), Positives = 102/252 (40%), Gaps = 39/252 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE + K A + R+K+Q ELT+ L L + L +E+L R ++
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEAT 2221
Query: 163 PGPTERERLKKMLSEGSV---------GEVQWEAEFFALQDSNN---------------- 197
+R ++++ L V ++ E L+D +N
Sbjct: 2222 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2281
Query: 198 KLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT-GEKEGLGQGQS 256
+ A L A AA+ RQ E A+ L +++ + + QA E T E E L Q +
Sbjct: 2282 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2341
Query: 257 L--EQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERS 314
L EQ L + K+Q Q L +T G + LEA + + + + +LR E S
Sbjct: 2342 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL----KLRVAEMS 2397
Query: 315 LEEARAERERAR 326
+ARAE + R
Sbjct: 2398 RAQARAEEDAQR 2409
Score = 47.0 bits (110), Expect = 3e-05
Identities = 51/176 (28%), Positives = 83/176 (47%), Gaps = 12/176 (6%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ-QLEAQR---- 221
ER RL+ + E V +Q EA + +L A A AQ RQ Q EA+R
Sbjct: 1448 ERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506
Query: 222 AEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGP 281
+ E R+R AE+E + + +E Q+LE+L +Q ++ E + +++
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR--LQAEEAERRLRQAEVERA 1564
Query: 282 RE---ALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 334
R+ ALE A+R + ++Q++ A + +ERSL+E + R E R AQ
Sbjct: 1565 RQVQVALETAQR-SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/250 (26%), Positives = 108/250 (43%), Gaps = 32/250 (12%)
Query: 108 EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
+V+EA RL Q+ A A ++ EEK A A E
Sbjct: 2021 KVEEARRLRERAEQESARQLQLAQEAAQKRLQ----------AEEKAH----AFAVQQKE 2066
Query: 168 RERLKKMLSEGSV-GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
+E + + E SV +++ EAE A + + + A +A AAQ R+Q+E EAER
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAEREAAQSRRQVE----EAER 2120
Query: 227 LRQRVAE-----LEAQAASE-VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGG 280
L+Q E +AQAA+E + E+E + Q+ + Q D E++ K
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 281 PREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARA---ERERARAEVGRAAQLLD 337
E+E T ++Q E +HQ ++ L+ +A E R R++V +
Sbjct: 2181 TLRQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 338 VSLFELSELR 347
V + ELS+L+
Sbjct: 2239 VQMEELSKLK 2248
Score = 45.4 bits (106), Expect = 8e-05
Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 13/154 (8%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEK----EGLGQGQSLEQLEALV 264
AA + ++L+A+ EA RLR+R + A+ +K E +++Q E +
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2069
Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRN--AELEHQLRAMERSLEEARAER 322
Q Q+ Q++ Q G EA A E + +VQ A+ Q+ ER L+++ E+
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQ 2128
Query: 323 ERARAEVGRAAQLLDVSLFELSELREGLARLAEA 356
+ARA+ AA+ L E + AR A+A
Sbjct: 2129 AQARAQAQAAAEKL------RKEAEQEAARRAQA 2156
Score = 43.1 bits (100), Expect = 4e-04
Identities = 51/187 (27%), Positives = 81/187 (43%), Gaps = 41/187 (21%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
EE+L Q A+ ERERL AE A + +LA A +A A A
Sbjct: 1351 EERLAEQQRAE-----ERERL---------------AEVEAALEKQRQLAEAHAQAKAQA 1390
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSL-EQLEALVQTKDQ 269
+ ++L+ QR + E +R+ A ++AQ Q +S+ E+L+ L Q+ +
Sbjct: 1391 EREAKELQ-QRMQEEVVRREEAAVDAQQ--------------QKRSIQEELQQLRQSSEA 1435
Query: 270 EIQTLKSQTGGPREALEAAEREETQQKVQTRNAE-----LEHQLRAMERSLEEARAERER 324
EIQ Q + E E ++Q E E +L+A+ EEA A++ +
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495
Query: 325 ARAEVGR 331
A+ E R
Sbjct: 1496 AQEEAER 1502
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/258 (23%), Positives = 106/258 (41%), Gaps = 25/258 (9%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E +R EKS+ E + + + ++ + +L +A ER
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER-LR 228
+K+ + G ++ EAE AL++ + R A A Q R++LE Q A+ + +
Sbjct: 1839 LAEKLAAIGEATRLKTEAEI-ALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIE 1896
Query: 229 QRVAELEAQAASEVTPTG-------------EKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
+R+A+L + SE+ E+E L S E+ A + E+ ++
Sbjct: 1897 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1956
Query: 276 SQTGGPREALEAAEREETQQKV-----QTRNAELEHQLRAMERSLEEARAERERARAEVG 330
S + E AE E +Q+ + R E E +++ + EEA +R+ A EV
Sbjct: 1957 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2016
Query: 331 RAAQLLDVSLFELSELRE 348
R L + E LRE
Sbjct: 2017 R----LKAKVEEARRLRE 2030
Score = 30.4 bits (67), Expect = 2.6
Identities = 53/246 (21%), Positives = 95/246 (38%), Gaps = 28/246 (11%)
Query: 96 EQHLTQFAEKFQ-EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL 154
EQ + + FQ EV +A +L E+ + ++ L + EE
Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-------------EEAR 2560
Query: 155 FRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR---EANAAAA 211
R A+ ++E L+++ E Q + L + N +L L+ E + AA
Sbjct: 2561 RRQHEAEEGVRRKQEELQQL-------EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2613
Query: 212 QWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEI 271
+++ A + A + + A+E P +GL + S ++L+ +E+
Sbjct: 2614 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2673
Query: 272 QTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGR 331
Q L G E A RE+ + +Q R++ L+A L A +R G
Sbjct: 2674 QRLAQ---GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL-SVYAALQRQLLSPGT 2729
Query: 332 AAQLLD 337
A LL+
Sbjct: 2730 ALILLE 2735
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 50.4 bits (119), Expect = 2e-06
Identities = 67/290 (23%), Positives = 118/290 (40%), Gaps = 44/290 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL--FRSQSA 160
A+K Q +EA RL R+ + + LAS + + L R Q+
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 161 DAP-----GPTERERLKKMLSEGSV--GEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
+A ER R ++ E + E + +++ + + +L +L+E + A AQ
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 214 RQQLEA---QRAEAERLRQRVA-ELE-------------------------AQAASEVTP 244
R++ E Q+AEAER R+ ELE AQA +E
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 245 T-GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAE 303
E+E +G++ EQ + +QE++ + G + AAE+E + + +T E
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 304 -----LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 348
LE +L ++R A +R+ AE+ + ++V L + E
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Score = 50.1 bits (118), Expect = 3e-06
Identities = 67/254 (26%), Positives = 103/254 (40%), Gaps = 31/254 (12%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1708 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1758
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1759 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1797
Query: 283 EALEAAEREETQQKVQTRNAELEHQLRAMERS-LEEARAERERARAEVGRAAQLLDVSLF 341
E E A R + R +L + A +R+ E AE+ A E R +++L
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857
Query: 342 ELSELREGLARLAE 355
E E L RLAE
Sbjct: 1858 EKEAENERLRRLAE 1871
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 112/260 (43%), Gaps = 27/260 (10%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 266 T----KDQEIQTLK--SQTGGPREAL---EAAEREETQQKVQTRNAELEHQLRAMERSLE 316
+ KD +Q + Q E L E A+ ++ +++ Q + ++E + + + S+E
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 317 EARAERERARAEVGRAAQLL 336
EAR + A V R + L
Sbjct: 2554 EARRRQHEAEEGVRRKQEEL 2573
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/252 (25%), Positives = 102/252 (40%), Gaps = 39/252 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE + K A + R+K+Q ELT+ L L + L +E+L R ++
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEAT 2217
Query: 163 PGPTERERLKKMLSEGSV---------GEVQWEAEFFALQDSNN---------------- 197
+R ++++ L V ++ E L+D +N
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 198 KLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT-GEKEGLGQGQS 256
+ A L A AA+ RQ E A+ L +++ + + QA E T E E L Q +
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 257 L--EQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERS 314
L EQ L + K+Q Q L +T G + LEA + + + + +LR E S
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL----KLRVAEMS 2393
Query: 315 LEEARAERERAR 326
+ARAE + R
Sbjct: 2394 RAQARAEEDAQR 2405
Score = 47.0 bits (110), Expect = 3e-05
Identities = 51/176 (28%), Positives = 83/176 (47%), Gaps = 12/176 (6%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ-QLEAQR---- 221
ER RL+ + E V +Q EA + +L A A AQ RQ Q EA+R
Sbjct: 1444 ERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 222 AEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGP 281
+ E R+R AE+E + + +E Q+LE+L +Q ++ E + +++
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR--LQAEEAERRLRQAEVERA 1560
Query: 282 RE---ALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 334
R+ ALE A+R + ++Q++ A + +ERSL+E + R E R AQ
Sbjct: 1561 RQVQVALETAQR-SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/250 (26%), Positives = 108/250 (43%), Gaps = 32/250 (12%)
Query: 108 EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
+V+EA RL Q+ A A ++ EEK A A E
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQ----------AEEKAH----AFAVQQKE 2062
Query: 168 RERLKKMLSEGSV-GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
+E + + E SV +++ EAE A + + + A +A AAQ R+Q+E EAER
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAEREAAQSRRQVE----EAER 2116
Query: 227 LRQRVAE-----LEAQAASE-VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGG 280
L+Q E +AQAA+E + E+E + Q+ + Q D E++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 281 PREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARA---ERERARAEVGRAAQLLD 337
E+E T ++Q E +HQ ++ L+ +A E R R++V +
Sbjct: 2177 TLRQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 338 VSLFELSELR 347
V + ELS+L+
Sbjct: 2235 VQMEELSKLK 2244
Score = 45.4 bits (106), Expect = 8e-05
Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 13/154 (8%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEK----EGLGQGQSLEQLEALV 264
AA + ++L+A+ EA RLR+R + A+ +K E +++Q E +
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRN--AELEHQLRAMERSLEEARAER 322
Q Q+ Q++ Q G EA A E + +VQ A+ Q+ ER L+++ E+
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQ 2124
Query: 323 ERARAEVGRAAQLLDVSLFELSELREGLARLAEA 356
+ARA+ AA+ L E + AR A+A
Sbjct: 2125 AQARAQAQAAAEKL------RKEAEQEAARRAQA 2152
Score = 43.1 bits (100), Expect = 4e-04
Identities = 51/187 (27%), Positives = 81/187 (43%), Gaps = 41/187 (21%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
EE+L Q A+ ERERL AE A + +LA A +A A A
Sbjct: 1347 EERLAEQQRAE-----ERERL---------------AEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSL-EQLEALVQTKDQ 269
+ ++L+ QR + E +R+ A ++AQ Q +S+ E+L+ L Q+ +
Sbjct: 1387 EREAKELQ-QRMQEEVVRREEAAVDAQQ--------------QKRSIQEELQQLRQSSEA 1431
Query: 270 EIQTLKSQTGGPREALEAAEREETQQKVQTRNAE-----LEHQLRAMERSLEEARAERER 324
EIQ Q + E E ++Q E E +L+A+ EEA A++ +
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 325 ARAEVGR 331
A+ E R
Sbjct: 1492 AQEEAER 1498
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/258 (23%), Positives = 106/258 (41%), Gaps = 25/258 (9%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E +R EKS+ E + + + ++ + +L +A ER
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER-LR 228
+K+ + G ++ EAE AL++ + R A A Q R++LE Q A+ + +
Sbjct: 1835 LAEKLAAIGEATRLKTEAEI-ALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIE 1892
Query: 229 QRVAELEAQAASEVTPTG-------------EKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
+R+A+L + SE+ E+E L S E+ A + E+ ++
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952
Query: 276 SQTGGPREALEAAEREETQQKV-----QTRNAELEHQLRAMERSLEEARAERERARAEVG 330
S + E AE E +Q+ + R E E +++ + EEA +R+ A EV
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 331 RAAQLLDVSLFELSELRE 348
R L + E LRE
Sbjct: 2013 R----LKAKVEEARRLRE 2026
Score = 30.4 bits (67), Expect = 2.6
Identities = 53/246 (21%), Positives = 95/246 (38%), Gaps = 28/246 (11%)
Query: 96 EQHLTQFAEKFQ-EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL 154
EQ + + FQ EV +A +L E+ + ++ L + EE
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-------------EEAR 2556
Query: 155 FRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR---EANAAAA 211
R A+ ++E L+++ E Q + L + N +L L+ E + AA
Sbjct: 2557 RRQHEAEEGVRRKQEELQQL-------EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 212 QWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEI 271
+++ A + A + + A+E P +GL + S ++L+ +E+
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2669
Query: 272 QTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGR 331
Q L G E A RE+ + +Q R++ L+A L A +R G
Sbjct: 2670 QRLAQ---GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL-SVYAALQRQLLSPGT 2725
Query: 332 AAQLLD 337
A LL+
Sbjct: 2726 ALILLE 2731
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 50.4 bits (119), Expect = 2e-06
Identities = 67/290 (23%), Positives = 118/290 (40%), Gaps = 44/290 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL--FRSQSA 160
A+K Q +EA RL R+ + + LAS + + L R Q+
Sbjct: 1455 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1514
Query: 161 DAP-----GPTERERLKKMLSEGSV--GEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
+A ER R ++ E + E + +++ + + +L +L+E + A AQ
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1574
Query: 214 RQQLEA---QRAEAERLRQRVA-ELE-------------------------AQAASEVTP 244
R++ E Q+AEAER R+ ELE AQA +E
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 245 T-GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAE 303
E+E +G++ EQ + +QE++ + G + AAE+E + + +T E
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694
Query: 304 -----LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 348
LE +L ++R A +R+ AE+ + ++V L + E
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744
Score = 50.1 bits (118), Expect = 3e-06
Identities = 67/254 (26%), Positives = 103/254 (40%), Gaps = 31/254 (12%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1676 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1726
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1727 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1765
Query: 283 EALEAAEREETQQKVQTRNAELEHQLRAMERS-LEEARAERERARAEVGRAAQLLDVSLF 341
E E A R + R +L + A +R+ E AE+ A E R +++L
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1825
Query: 342 ELSELREGLARLAE 355
E E L RLAE
Sbjct: 1826 EKEAENERLRRLAE 1839
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 112/260 (43%), Gaps = 27/260 (10%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461
Query: 266 T----KDQEIQTLK--SQTGGPREAL---EAAEREETQQKVQTRNAELEHQLRAMERSLE 316
+ KD +Q + Q E L E A+ ++ +++ Q + ++E + + + S+E
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2521
Query: 317 EARAERERARAEVGRAAQLL 336
EAR + A V R + L
Sbjct: 2522 EARRRQHEAEEGVRRKQEEL 2541
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/252 (25%), Positives = 102/252 (40%), Gaps = 39/252 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE + K A + R+K+Q ELT+ L L + L +E+L R ++
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEAT 2185
Query: 163 PGPTERERLKKMLSEGSV---------GEVQWEAEFFALQDSNN---------------- 197
+R ++++ L V ++ E L+D +N
Sbjct: 2186 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2245
Query: 198 KLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT-GEKEGLGQGQS 256
+ A L A AA+ RQ E A+ L +++ + + QA E T E E L Q +
Sbjct: 2246 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2305
Query: 257 L--EQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERS 314
L EQ L + K+Q Q L +T G + LEA + + + + +LR E S
Sbjct: 2306 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL----KLRVAEMS 2361
Query: 315 LEEARAERERAR 326
+ARAE + R
Sbjct: 2362 RAQARAEEDAQR 2373
Score = 47.0 bits (110), Expect = 3e-05
Identities = 51/176 (28%), Positives = 83/176 (47%), Gaps = 12/176 (6%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ-QLEAQR---- 221
ER RL+ + E V +Q EA + +L A A AQ RQ Q EA+R
Sbjct: 1412 ERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470
Query: 222 AEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGP 281
+ E R+R AE+E + + +E Q+LE+L +Q ++ E + +++
Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR--LQAEEAERRLRQAEVERA 1528
Query: 282 RE---ALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 334
R+ ALE A+R + ++Q++ A + +ERSL+E + R E R AQ
Sbjct: 1529 RQVQVALETAQR-SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/250 (26%), Positives = 108/250 (43%), Gaps = 32/250 (12%)
Query: 108 EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
+V+EA RL Q+ A A ++ EEK A A E
Sbjct: 1985 KVEEARRLRERAEQESARQLQLAQEAAQKRLQ----------AEEKAH----AFAVQQKE 2030
Query: 168 RERLKKMLSEGSV-GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
+E + + E SV +++ EAE A + + + A +A AAQ R+Q+E EAER
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAEREAAQSRRQVE----EAER 2084
Query: 227 LRQRVAE-----LEAQAASE-VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGG 280
L+Q E +AQAA+E + E+E + Q+ + Q D E++ K
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 281 PREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARA---ERERARAEVGRAAQLLD 337
E+E T ++Q E +HQ ++ L+ +A E R R++V +
Sbjct: 2145 TLRQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 338 VSLFELSELR 347
V + ELS+L+
Sbjct: 2203 VQMEELSKLK 2212
Score = 45.4 bits (106), Expect = 8e-05
Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 13/154 (8%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEK----EGLGQGQSLEQLEALV 264
AA + ++L+A+ EA RLR+R + A+ +K E +++Q E +
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2033
Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRN--AELEHQLRAMERSLEEARAER 322
Q Q+ Q++ Q G EA A E + +VQ A+ Q+ ER L+++ E+
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQ 2092
Query: 323 ERARAEVGRAAQLLDVSLFELSELREGLARLAEA 356
+ARA+ AA+ L E + AR A+A
Sbjct: 2093 AQARAQAQAAAEKL------RKEAEQEAARRAQA 2120
Score = 43.1 bits (100), Expect = 4e-04
Identities = 51/187 (27%), Positives = 81/187 (43%), Gaps = 41/187 (21%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
EE+L Q A+ ERERL AE A + +LA A +A A A
Sbjct: 1315 EERLAEQQRAE-----ERERL---------------AEVEAALEKQRQLAEAHAQAKAQA 1354
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSL-EQLEALVQTKDQ 269
+ ++L+ QR + E +R+ A ++AQ Q +S+ E+L+ L Q+ +
Sbjct: 1355 EREAKELQ-QRMQEEVVRREEAAVDAQQ--------------QKRSIQEELQQLRQSSEA 1399
Query: 270 EIQTLKSQTGGPREALEAAEREETQQKVQTRNAE-----LEHQLRAMERSLEEARAERER 324
EIQ Q + E E ++Q E E +L+A+ EEA A++ +
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459
Query: 325 ARAEVGR 331
A+ E R
Sbjct: 1460 AQEEAER 1466
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/258 (23%), Positives = 106/258 (41%), Gaps = 25/258 (9%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E +R EKS+ E + + + ++ + +L +A ER
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER-LR 228
+K+ + G ++ EAE AL++ + R A A Q R++LE Q A+ + +
Sbjct: 1803 LAEKLAAIGEATRLKTEAEI-ALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIE 1860
Query: 229 QRVAELEAQAASEVTPTG-------------EKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
+R+A+L + SE+ E+E L S E+ A + E+ ++
Sbjct: 1861 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1920
Query: 276 SQTGGPREALEAAEREETQQKV-----QTRNAELEHQLRAMERSLEEARAERERARAEVG 330
S + E AE E +Q+ + R E E +++ + EEA +R+ A EV
Sbjct: 1921 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1980
Query: 331 RAAQLLDVSLFELSELRE 348
R L + E LRE
Sbjct: 1981 R----LKAKVEEARRLRE 1994
Score = 30.4 bits (67), Expect = 2.6
Identities = 53/246 (21%), Positives = 95/246 (38%), Gaps = 28/246 (11%)
Query: 96 EQHLTQFAEKFQ-EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL 154
EQ + + FQ EV +A +L E+ + ++ L + EE
Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-------------EEAR 2524
Query: 155 FRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR---EANAAAA 211
R A+ ++E L+++ E Q + L + N +L L+ E + AA
Sbjct: 2525 RRQHEAEEGVRRKQEELQQL-------EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2577
Query: 212 QWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEI 271
+++ A + A + + A+E P +GL + S ++L+ +E+
Sbjct: 2578 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2637
Query: 272 QTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGR 331
Q L G E A RE+ + +Q R++ L+A L A +R G
Sbjct: 2638 QRLAQ---GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL-SVYAALQRQLLSPGT 2693
Query: 332 AAQLLD 337
A LL+
Sbjct: 2694 ALILLE 2699
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 50.4 bits (119), Expect = 2e-06
Identities = 67/290 (23%), Positives = 118/290 (40%), Gaps = 44/290 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL--FRSQSA 160
A+K Q +EA RL R+ + + LAS + + L R Q+
Sbjct: 1624 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1683
Query: 161 DAP-----GPTERERLKKMLSEGSV--GEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
+A ER R ++ E + E + +++ + + +L +L+E + A AQ
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743
Query: 214 RQQLEA---QRAEAERLRQRVA-ELE-------------------------AQAASEVTP 244
R++ E Q+AEAER R+ ELE AQA +E
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 245 T-GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAE 303
E+E +G++ EQ + +QE++ + G + AAE+E + + +T E
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863
Query: 304 -----LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 348
LE +L ++R A +R+ AE+ + ++V L + E
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913
Score = 50.1 bits (118), Expect = 3e-06
Identities = 67/254 (26%), Positives = 103/254 (40%), Gaps = 31/254 (12%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1845 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1895
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1896 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1934
Query: 283 EALEAAEREETQQKVQTRNAELEHQLRAMERS-LEEARAERERARAEVGRAAQLLDVSLF 341
E E A R + R +L + A +R+ E AE+ A E R +++L
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1994
Query: 342 ELSELREGLARLAE 355
E E L RLAE
Sbjct: 1995 EKEAENERLRRLAE 2008
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 112/260 (43%), Gaps = 27/260 (10%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630
Query: 266 T----KDQEIQTLK--SQTGGPREAL---EAAEREETQQKVQTRNAELEHQLRAMERSLE 316
+ KD +Q + Q E L E A+ ++ +++ Q + ++E + + + S+E
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690
Query: 317 EARAERERARAEVGRAAQLL 336
EAR + A V R + L
Sbjct: 2691 EARRRQHEAEEGVRRKQEEL 2710
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/252 (25%), Positives = 102/252 (40%), Gaps = 39/252 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE + K A + R+K+Q ELT+ L L + L +E+L R ++
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEAT 2354
Query: 163 PGPTERERLKKMLSEGSV---------GEVQWEAEFFALQDSNN---------------- 197
+R ++++ L V ++ E L+D +N
Sbjct: 2355 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2414
Query: 198 KLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT-GEKEGLGQGQS 256
+ A L A AA+ RQ E A+ L +++ + + QA E T E E L Q +
Sbjct: 2415 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2474
Query: 257 L--EQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERS 314
L EQ L + K+Q Q L +T G + LEA + + + + +LR E S
Sbjct: 2475 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL----KLRVAEMS 2530
Query: 315 LEEARAERERAR 326
+ARAE + R
Sbjct: 2531 RAQARAEEDAQR 2542
Score = 47.0 bits (110), Expect = 3e-05
Identities = 51/176 (28%), Positives = 83/176 (47%), Gaps = 12/176 (6%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ-QLEAQR---- 221
ER RL+ + E V +Q EA + +L A A AQ RQ Q EA+R
Sbjct: 1581 ERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639
Query: 222 AEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGP 281
+ E R+R AE+E + + +E Q+LE+L +Q ++ E + +++
Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR--LQAEEAERRLRQAEVERA 1697
Query: 282 RE---ALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 334
R+ ALE A+R + ++Q++ A + +ERSL+E + R E R AQ
Sbjct: 1698 RQVQVALETAQR-SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/250 (26%), Positives = 108/250 (43%), Gaps = 32/250 (12%)
Query: 108 EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
+V+EA RL Q+ A A ++ EEK A A E
Sbjct: 2154 KVEEARRLRERAEQESARQLQLAQEAAQKRLQ----------AEEKAH----AFAVQQKE 2199
Query: 168 RERLKKMLSEGSV-GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
+E + + E SV +++ EAE A + + + A +A AAQ R+Q+E EAER
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAEREAAQSRRQVE----EAER 2253
Query: 227 LRQRVAE-----LEAQAASE-VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGG 280
L+Q E +AQAA+E + E+E + Q+ + Q D E++ K
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 281 PREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARA---ERERARAEVGRAAQLLD 337
E+E T ++Q E +HQ ++ L+ +A E R R++V +
Sbjct: 2314 TLRQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 338 VSLFELSELR 347
V + ELS+L+
Sbjct: 2372 VQMEELSKLK 2381
Score = 45.4 bits (106), Expect = 8e-05
Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 13/154 (8%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEK----EGLGQGQSLEQLEALV 264
AA + ++L+A+ EA RLR+R + A+ +K E +++Q E +
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2202
Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRN--AELEHQLRAMERSLEEARAER 322
Q Q+ Q++ Q G EA A E + +VQ A+ Q+ ER L+++ E+
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQ 2261
Query: 323 ERARAEVGRAAQLLDVSLFELSELREGLARLAEA 356
+ARA+ AA+ L E + AR A+A
Sbjct: 2262 AQARAQAQAAAEKL------RKEAEQEAARRAQA 2289
Score = 43.1 bits (100), Expect = 4e-04
Identities = 51/187 (27%), Positives = 81/187 (43%), Gaps = 41/187 (21%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
EE+L Q A+ ERERL AE A + +LA A +A A A
Sbjct: 1484 EERLAEQQRAE-----ERERL---------------AEVEAALEKQRQLAEAHAQAKAQA 1523
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSL-EQLEALVQTKDQ 269
+ ++L+ QR + E +R+ A ++AQ Q +S+ E+L+ L Q+ +
Sbjct: 1524 EREAKELQ-QRMQEEVVRREEAAVDAQQ--------------QKRSIQEELQQLRQSSEA 1568
Query: 270 EIQTLKSQTGGPREALEAAEREETQQKVQTRNAE-----LEHQLRAMERSLEEARAERER 324
EIQ Q + E E ++Q E E +L+A+ EEA A++ +
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628
Query: 325 ARAEVGR 331
A+ E R
Sbjct: 1629 AQEEAER 1635
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/258 (23%), Positives = 106/258 (41%), Gaps = 25/258 (9%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E +R EKS+ E + + + ++ + +L +A ER
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER-LR 228
+K+ + G ++ EAE AL++ + R A A Q R++LE Q A+ + +
Sbjct: 1972 LAEKLAAIGEATRLKTEAEI-ALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIE 2029
Query: 229 QRVAELEAQAASEVTPTG-------------EKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
+R+A+L + SE+ E+E L S E+ A + E+ ++
Sbjct: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 2089
Query: 276 SQTGGPREALEAAEREETQQKV-----QTRNAELEHQLRAMERSLEEARAERERARAEVG 330
S + E AE E +Q+ + R E E +++ + EEA +R+ A EV
Sbjct: 2090 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2149
Query: 331 RAAQLLDVSLFELSELRE 348
R L + E LRE
Sbjct: 2150 R----LKAKVEEARRLRE 2163
Score = 30.4 bits (67), Expect = 2.6
Identities = 53/246 (21%), Positives = 95/246 (38%), Gaps = 28/246 (11%)
Query: 96 EQHLTQFAEKFQ-EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL 154
EQ + + FQ EV +A +L E+ + ++ L + EE
Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-------------EEAR 2693
Query: 155 FRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR---EANAAAA 211
R A+ ++E L+++ E Q + L + N +L L+ E + AA
Sbjct: 2694 RRQHEAEEGVRRKQEELQQL-------EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2746
Query: 212 QWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEI 271
+++ A + A + + A+E P +GL + S ++L+ +E+
Sbjct: 2747 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2806
Query: 272 QTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGR 331
Q L G E A RE+ + +Q R++ L+A L A +R G
Sbjct: 2807 QRLAQ---GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL-SVYAALQRQLLSPGT 2862
Query: 332 AAQLLD 337
A LL+
Sbjct: 2863 ALILLE 2868
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 50.4 bits (119), Expect = 2e-06
Identities = 67/290 (23%), Positives = 118/290 (40%), Gaps = 44/290 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL--FRSQSA 160
A+K Q +EA RL R+ + + LAS + + L R Q+
Sbjct: 1465 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1524
Query: 161 DAP-----GPTERERLKKMLSEGSV--GEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
+A ER R ++ E + E + +++ + + +L +L+E + A AQ
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1584
Query: 214 RQQLEA---QRAEAERLRQRVA-ELE-------------------------AQAASEVTP 244
R++ E Q+AEAER R+ ELE AQA +E
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 245 T-GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAE 303
E+E +G++ EQ + +QE++ + G + AAE+E + + +T E
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
Query: 304 -----LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 348
LE +L ++R A +R+ AE+ + ++V L + E
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
Score = 50.1 bits (118), Expect = 3e-06
Identities = 67/254 (26%), Positives = 103/254 (40%), Gaps = 31/254 (12%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1686 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1736
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1737 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1775
Query: 283 EALEAAEREETQQKVQTRNAELEHQLRAMERS-LEEARAERERARAEVGRAAQLLDVSLF 341
E E A R + R +L + A +R+ E AE+ A E R +++L
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1835
Query: 342 ELSELREGLARLAE 355
E E L RLAE
Sbjct: 1836 EKEAENERLRRLAE 1849
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 112/260 (43%), Gaps = 27/260 (10%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471
Query: 266 T----KDQEIQTLK--SQTGGPREAL---EAAEREETQQKVQTRNAELEHQLRAMERSLE 316
+ KD +Q + Q E L E A+ ++ +++ Q + ++E + + + S+E
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
Query: 317 EARAERERARAEVGRAAQLL 336
EAR + A V R + L
Sbjct: 2532 EARRRQHEAEEGVRRKQEEL 2551
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/252 (25%), Positives = 102/252 (40%), Gaps = 39/252 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE + K A + R+K+Q ELT+ L L + L +E+L R ++
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEAT 2195
Query: 163 PGPTERERLKKMLSEGSV---------GEVQWEAEFFALQDSNN---------------- 197
+R ++++ L V ++ E L+D +N
Sbjct: 2196 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2255
Query: 198 KLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT-GEKEGLGQGQS 256
+ A L A AA+ RQ E A+ L +++ + + QA E T E E L Q +
Sbjct: 2256 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2315
Query: 257 L--EQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERS 314
L EQ L + K+Q Q L +T G + LEA + + + + +LR E S
Sbjct: 2316 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL----KLRVAEMS 2371
Query: 315 LEEARAERERAR 326
+ARAE + R
Sbjct: 2372 RAQARAEEDAQR 2383
Score = 47.0 bits (110), Expect = 3e-05
Identities = 51/176 (28%), Positives = 83/176 (47%), Gaps = 12/176 (6%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ-QLEAQR---- 221
ER RL+ + E V +Q EA + +L A A AQ RQ Q EA+R
Sbjct: 1422 ERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480
Query: 222 AEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGP 281
+ E R+R AE+E + + +E Q+LE+L +Q ++ E + +++
Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR--LQAEEAERRLRQAEVERA 1538
Query: 282 RE---ALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 334
R+ ALE A+R + ++Q++ A + +ERSL+E + R E R AQ
Sbjct: 1539 RQVQVALETAQR-SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/250 (26%), Positives = 108/250 (43%), Gaps = 32/250 (12%)
Query: 108 EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
+V+EA RL Q+ A A ++ EEK A A E
Sbjct: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQ----------AEEKAH----AFAVQQKE 2040
Query: 168 RERLKKMLSEGSV-GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
+E + + E SV +++ EAE A + + + A +A AAQ R+Q+E EAER
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAEREAAQSRRQVE----EAER 2094
Query: 227 LRQRVAE-----LEAQAASE-VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGG 280
L+Q E +AQAA+E + E+E + Q+ + Q D E++ K
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 281 PREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARA---ERERARAEVGRAAQLLD 337
E+E T ++Q E +HQ ++ L+ +A E R R++V +
Sbjct: 2155 TLRQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 338 VSLFELSELR 347
V + ELS+L+
Sbjct: 2213 VQMEELSKLK 2222
Score = 45.4 bits (106), Expect = 8e-05
Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 13/154 (8%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEK----EGLGQGQSLEQLEALV 264
AA + ++L+A+ EA RLR+R + A+ +K E +++Q E +
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2043
Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRN--AELEHQLRAMERSLEEARAER 322
Q Q+ Q++ Q G EA A E + +VQ A+ Q+ ER L+++ E+
Sbjct: 2044 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQ 2102
Query: 323 ERARAEVGRAAQLLDVSLFELSELREGLARLAEA 356
+ARA+ AA+ L E + AR A+A
Sbjct: 2103 AQARAQAQAAAEKL------RKEAEQEAARRAQA 2130
Score = 43.1 bits (100), Expect = 4e-04
Identities = 51/187 (27%), Positives = 81/187 (43%), Gaps = 41/187 (21%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
EE+L Q A+ ERERL AE A + +LA A +A A A
Sbjct: 1325 EERLAEQQRAE-----ERERL---------------AEVEAALEKQRQLAEAHAQAKAQA 1364
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSL-EQLEALVQTKDQ 269
+ ++L+ QR + E +R+ A ++AQ Q +S+ E+L+ L Q+ +
Sbjct: 1365 EREAKELQ-QRMQEEVVRREEAAVDAQQ--------------QKRSIQEELQQLRQSSEA 1409
Query: 270 EIQTLKSQTGGPREALEAAEREETQQKVQTRNAE-----LEHQLRAMERSLEEARAERER 324
EIQ Q + E E ++Q E E +L+A+ EEA A++ +
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
Query: 325 ARAEVGR 331
A+ E R
Sbjct: 1470 AQEEAER 1476
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/258 (23%), Positives = 106/258 (41%), Gaps = 25/258 (9%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E +R EKS+ E + + + ++ + +L +A ER
Sbjct: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER-LR 228
+K+ + G ++ EAE AL++ + R A A Q R++LE Q A+ + +
Sbjct: 1813 LAEKLAAIGEATRLKTEAEI-ALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIE 1870
Query: 229 QRVAELEAQAASEVTPTG-------------EKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
+R+A+L + SE+ E+E L S E+ A + E+ ++
Sbjct: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1930
Query: 276 SQTGGPREALEAAEREETQQKV-----QTRNAELEHQLRAMERSLEEARAERERARAEVG 330
S + E AE E +Q+ + R E E +++ + EEA +R+ A EV
Sbjct: 1931 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1990
Query: 331 RAAQLLDVSLFELSELRE 348
R L + E LRE
Sbjct: 1991 R----LKAKVEEARRLRE 2004
Score = 30.4 bits (67), Expect = 2.6
Identities = 53/246 (21%), Positives = 95/246 (38%), Gaps = 28/246 (11%)
Query: 96 EQHLTQFAEKFQ-EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL 154
EQ + + FQ EV +A +L E+ + ++ L + EE
Sbjct: 2488 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-------------EEAR 2534
Query: 155 FRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR---EANAAAA 211
R A+ ++E L+++ E Q + L + N +L L+ E + AA
Sbjct: 2535 RRQHEAEEGVRRKQEELQQL-------EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2587
Query: 212 QWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEI 271
+++ A + A + + A+E P +GL + S ++L+ +E+
Sbjct: 2588 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2647
Query: 272 QTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGR 331
Q L G E A RE+ + +Q R++ L+A L A +R G
Sbjct: 2648 QRLAQ---GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL-SVYAALQRQLLSPGT 2703
Query: 332 AAQLLD 337
A LL+
Sbjct: 2704 ALILLE 2709
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 50.4 bits (119), Expect = 2e-06
Identities = 67/290 (23%), Positives = 118/290 (40%), Gaps = 44/290 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL--FRSQSA 160
A+K Q +EA RL R+ + + LAS + + L R Q+
Sbjct: 1473 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1532
Query: 161 DAP-----GPTERERLKKMLSEGSV--GEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
+A ER R ++ E + E + +++ + + +L +L+E + A AQ
Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1592
Query: 214 RQQLEA---QRAEAERLRQRVA-ELE-------------------------AQAASEVTP 244
R++ E Q+AEAER R+ ELE AQA +E
Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652
Query: 245 T-GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAE 303
E+E +G++ EQ + +QE++ + G + AAE+E + + +T E
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712
Query: 304 -----LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 348
LE +L ++R A +R+ AE+ + ++V L + E
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762
Score = 50.1 bits (118), Expect = 3e-06
Identities = 67/254 (26%), Positives = 103/254 (40%), Gaps = 31/254 (12%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1693
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1694 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1744
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1745 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1783
Query: 283 EALEAAEREETQQKVQTRNAELEHQLRAMERS-LEEARAERERARAEVGRAAQLLDVSLF 341
E E A R + R +L + A +R+ E AE+ A E R +++L
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1843
Query: 342 ELSELREGLARLAE 355
E E L RLAE
Sbjct: 1844 EKEAENERLRRLAE 1857
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 112/260 (43%), Gaps = 27/260 (10%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479
Query: 266 T----KDQEIQTLK--SQTGGPREAL---EAAEREETQQKVQTRNAELEHQLRAMERSLE 316
+ KD +Q + Q E L E A+ ++ +++ Q + ++E + + + S+E
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2539
Query: 317 EARAERERARAEVGRAAQLL 336
EAR + A V R + L
Sbjct: 2540 EARRRQHEAEEGVRRKQEEL 2559
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/252 (25%), Positives = 102/252 (40%), Gaps = 39/252 (15%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE + K A + R+K+Q ELT+ L L + L +E+L R ++
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEAT 2203
Query: 163 PGPTERERLKKMLSEGSV---------GEVQWEAEFFALQDSNN---------------- 197
+R ++++ L V ++ E L+D +N
Sbjct: 2204 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2263
Query: 198 KLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT-GEKEGLGQGQS 256
+ A L A AA+ RQ E A+ L +++ + + QA E T E E L Q +
Sbjct: 2264 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2323
Query: 257 L--EQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERS 314
L EQ L + K+Q Q L +T G + LEA + + + + +LR E S
Sbjct: 2324 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL----KLRVAEMS 2379
Query: 315 LEEARAERERAR 326
+ARAE + R
Sbjct: 2380 RAQARAEEDAQR 2391
Score = 47.0 bits (110), Expect = 3e-05
Identities = 51/176 (28%), Positives = 83/176 (47%), Gaps = 12/176 (6%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ-QLEAQR---- 221
ER RL+ + E V +Q EA + +L A A AQ RQ Q EA+R
Sbjct: 1430 ERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488
Query: 222 AEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGP 281
+ E R+R AE+E + + +E Q+LE+L +Q ++ E + +++
Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR--LQAEEAERRLRQAEVERA 1546
Query: 282 RE---ALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 334
R+ ALE A+R + ++Q++ A + +ERSL+E + R E R AQ
Sbjct: 1547 RQVQVALETAQR-SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/250 (26%), Positives = 108/250 (43%), Gaps = 32/250 (12%)
Query: 108 EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
+V+EA RL Q+ A A ++ EEK A A E
Sbjct: 2003 KVEEARRLRERAEQESARQLQLAQEAAQKRLQ----------AEEKAH----AFAVQQKE 2048
Query: 168 RERLKKMLSEGSV-GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
+E + + E SV +++ EAE A + + + A +A AAQ R+Q+E EAER
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAEREAAQSRRQVE----EAER 2102
Query: 227 LRQRVAE-----LEAQAASE-VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGG 280
L+Q E +AQAA+E + E+E + Q+ + Q D E++ K
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 281 PREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARA---ERERARAEVGRAAQLLD 337
E+E T ++Q E +HQ ++ L+ +A E R R++V +
Sbjct: 2163 TLRQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 338 VSLFELSELR 347
V + ELS+L+
Sbjct: 2221 VQMEELSKLK 2230
Score = 45.4 bits (106), Expect = 8e-05
Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 13/154 (8%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEK----EGLGQGQSLEQLEALV 264
AA + ++L+A+ EA RLR+R + A+ +K E +++Q E +
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2051
Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRN--AELEHQLRAMERSLEEARAER 322
Q Q+ Q++ Q G EA A E + +VQ A+ Q+ ER L+++ E+
Sbjct: 2052 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQ 2110
Query: 323 ERARAEVGRAAQLLDVSLFELSELREGLARLAEA 356
+ARA+ AA+ L E + AR A+A
Sbjct: 2111 AQARAQAQAAAEKL------RKEAEQEAARRAQA 2138
Score = 43.1 bits (100), Expect = 4e-04
Identities = 51/187 (27%), Positives = 81/187 (43%), Gaps = 41/187 (21%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
EE+L Q A+ ERERL AE A + +LA A +A A A
Sbjct: 1333 EERLAEQQRAE-----ERERL---------------AEVEAALEKQRQLAEAHAQAKAQA 1372
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSL-EQLEALVQTKDQ 269
+ ++L+ QR + E +R+ A ++AQ Q +S+ E+L+ L Q+ +
Sbjct: 1373 EREAKELQ-QRMQEEVVRREEAAVDAQQ--------------QKRSIQEELQQLRQSSEA 1417
Query: 270 EIQTLKSQTGGPREALEAAEREETQQKVQTRNAE-----LEHQLRAMERSLEEARAERER 324
EIQ Q + E E ++Q E E +L+A+ EEA A++ +
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477
Query: 325 ARAEVGR 331
A+ E R
Sbjct: 1478 AQEEAER 1484
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/258 (23%), Positives = 106/258 (41%), Gaps = 25/258 (9%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E +R EKS+ E + + + ++ + +L +A ER
Sbjct: 1761 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1820
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER-LR 228
+K+ + G ++ EAE AL++ + R A A Q R++LE Q A+ + +
Sbjct: 1821 LAEKLAAIGEATRLKTEAEI-ALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIE 1878
Query: 229 QRVAELEAQAASEVTPTG-------------EKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
+R+A+L + SE+ E+E L S E+ A + E+ ++
Sbjct: 1879 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1938
Query: 276 SQTGGPREALEAAEREETQQKV-----QTRNAELEHQLRAMERSLEEARAERERARAEVG 330
S + E AE E +Q+ + R E E +++ + EEA +R+ A EV
Sbjct: 1939 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1998
Query: 331 RAAQLLDVSLFELSELRE 348
R L + E LRE
Sbjct: 1999 R----LKAKVEEARRLRE 2012
Score = 30.4 bits (67), Expect = 2.6
Identities = 53/246 (21%), Positives = 95/246 (38%), Gaps = 28/246 (11%)
Query: 96 EQHLTQFAEKFQ-EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL 154
EQ + + FQ EV +A +L E+ + ++ L + EE
Sbjct: 2496 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-------------EEAR 2542
Query: 155 FRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR---EANAAAA 211
R A+ ++E L+++ E Q + L + N +L L+ E + AA
Sbjct: 2543 RRQHEAEEGVRRKQEELQQL-------EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2595
Query: 212 QWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEI 271
+++ A + A + + A+E P +GL + S ++L+ +E+
Sbjct: 2596 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2655
Query: 272 QTLKSQTGGPREALEAAEREETQQKVQTRNAELEHQLRAMERSLEEARAERERARAEVGR 331
Q L G E A RE+ + +Q R++ L+A L A +R G
Sbjct: 2656 QRLAQ---GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL-SVYAALQRQLLSPGT 2711
Query: 332 AAQLLD 337
A LL+
Sbjct: 2712 ALILLE 2717
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.124 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,319,542
Number of Sequences: 37866
Number of extensions: 542535
Number of successful extensions: 5619
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 613
Number of HSP's that attempted gapping in prelim test: 3360
Number of HSP's gapped (non-prelim): 2090
length of query: 358
length of database: 18,247,518
effective HSP length: 103
effective length of query: 255
effective length of database: 14,347,320
effective search space: 3658566600
effective search space used: 3658566600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.