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Search of human proteins with 120952764
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|120952764 mastermind-like domain containing 1 [Homo sapiens]
(774 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|120952764 mastermind-like domain containing 1 [Homo sapiens] 1568 0.0
gi|33286444 mastermind-like 2 [Homo sapiens] 107 3e-23
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens] 68 3e-11
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens] 68 3e-11
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens] 68 3e-11
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 67 6e-11
gi|55750053 atrophin-1 [Homo sapiens] 67 8e-11
gi|55750041 atrophin-1 [Homo sapiens] 67 8e-11
gi|56549696 E1A binding protein p400 [Homo sapiens] 65 2e-10
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 65 3e-10
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 63 9e-10
gi|163965366 nascent polypeptide-associated complex alpha subuni... 63 9e-10
gi|38158015 mastermind-like 3 [Homo sapiens] 62 2e-09
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] 61 3e-09
gi|150417989 cyclin K isoform 1 [Homo sapiens] 61 3e-09
gi|146219843 Snf2-related CBP activator protein [Homo sapiens] 61 5e-09
gi|150170670 piccolo isoform 2 [Homo sapiens] 60 1e-08
gi|150378539 piccolo isoform 1 [Homo sapiens] 60 1e-08
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 59 1e-08
gi|119943102 CREB binding protein isoform b [Homo sapiens] 59 2e-08
gi|119943104 CREB binding protein isoform a [Homo sapiens] 59 2e-08
gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens] 59 2e-08
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin... 59 2e-08
gi|58530876 melanoma antigen family C, 1 [Homo sapiens] 58 4e-08
gi|11386183 WAS protein family, member 2 [Homo sapiens] 57 5e-08
gi|50428940 mediator complex subunit 25 [Homo sapiens] 57 5e-08
gi|47132519 Ras association and pleckstrin homology domains 1 is... 57 7e-08
gi|221139926 NHS-like 1 [Homo sapiens] 57 9e-08
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 57 9e-08
gi|50345997 E1A binding protein p300 [Homo sapiens] 56 1e-07
>gi|120952764 mastermind-like domain containing 1 [Homo sapiens]
Length = 774
Score = 1568 bits (4061), Expect = 0.0
Identities = 774/774 (100%), Positives = 774/774 (100%)
Query: 1 MDDWKSRLVIKSMLPHFAMVGNRQEPRKLQESGKKPSWMEEEDLSFLYKSSPGRKHQGTV 60
MDDWKSRLVIKSMLPHFAMVGNRQEPRKLQESGKKPSWMEEEDLSFLYKSSPGRKHQGTV
Sbjct: 1 MDDWKSRLVIKSMLPHFAMVGNRQEPRKLQESGKKPSWMEEEDLSFLYKSSPGRKHQGTV 60
Query: 61 KRRQEEDHFQFPDMADGGYPNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPA 120
KRRQEEDHFQFPDMADGGYPNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPA
Sbjct: 61 KRRQEEDHFQFPDMADGGYPNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPA 120
Query: 121 AMGVAGQSLLLENNPMNGNIMGSPFVVPQTTEVGLKGPTVPYYEKINSVPAVDQELQELL 180
AMGVAGQSLLLENNPMNGNIMGSPFVVPQTTEVGLKGPTVPYYEKINSVPAVDQELQELL
Sbjct: 121 AMGVAGQSLLLENNPMNGNIMGSPFVVPQTTEVGLKGPTVPYYEKINSVPAVDQELQELL 180
Query: 181 EELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFA 240
EELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFA
Sbjct: 181 EELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFA 240
Query: 241 SSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQ 300
SSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQ
Sbjct: 241 SSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQ 300
Query: 301 WHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPF 360
WHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPF
Sbjct: 301 WHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPF 360
Query: 361 SPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQ 420
SPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQ
Sbjct: 361 SPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQ 420
Query: 421 FGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLI 480
FGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLI
Sbjct: 421 FGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLI 480
Query: 481 RSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFG 540
RSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFG
Sbjct: 481 RSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFG 540
Query: 541 NTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQ 600
NTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQ
Sbjct: 541 NTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQ 600
Query: 601 QQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVKPQHQH 660
QQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVKPQHQH
Sbjct: 601 QQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVKPQHQH 660
Query: 661 GNSFTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSF 720
GNSFTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSF
Sbjct: 661 GNSFTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSF 720
Query: 721 AHELARVTSSYSTSEAAPWGSWDPKAWRQVPAPLLPSCDATARGTEIRSYGNDP 774
AHELARVTSSYSTSEAAPWGSWDPKAWRQVPAPLLPSCDATARGTEIRSYGNDP
Sbjct: 721 AHELARVTSSYSTSEAAPWGSWDPKAWRQVPAPLLPSCDATARGTEIRSYGNDP 774
>gi|33286444 mastermind-like 2 [Homo sapiens]
Length = 1156
Score = 107 bits (268), Expect = 3e-23
Identities = 122/487 (25%), Positives = 186/487 (38%), Gaps = 72/487 (14%)
Query: 172 VDQELQELLEELTKIQDPSPNELDLEKILGT--KPEEPLVLDHPQATLSTTPKPSVQMSH 229
+D ELQEL ELT I P ++L+LE ++ K ++P +D Q + +TP+PS+ M
Sbjct: 302 MDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPM-- 359
Query: 230 LESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAML 289
E + E++ +Q S Q+ S G ++S+ +++ SP S+ QS++Q Q
Sbjct: 360 -EKIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGS 418
Query: 290 PVALPPLPVPQWH---HAHQLKALAASKQGSAT----KQQGPTPSWSGLPPPGLSPPYRP 342
+ +P W HA QLK +AA++Q A +QQ +WS LP
Sbjct: 419 GAS---RALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSA------- 468
Query: 343 VPSPHPPPLPLPPPPPP------FSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSN 396
P P P P P FSPQS + ++ + + N + + S+
Sbjct: 469 --GPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVM---ANYMYKAGPSAQG 523
Query: 397 AALGPAMPYAPEKLPSPALTQ-QPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPS 455
L M P+ L + P P+ L + S LP+ N
Sbjct: 524 GHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSL 583
Query: 456 PPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSS 515
Y ++ QQ Q QQQQQQQQQQQ IS+
Sbjct: 584 LHYTQQQQQQQQQQQQQQQQQ--------------QQQQQQQQQQQQQQQQQSSISA--- 626
Query: 516 KTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQ 575
QQ SS A + + Q+ +Q QQ
Sbjct: 627 ------QQQQQQQSSISAQQ---------------QQQQQQQQQQQQQQQQQQQQQQQQQ 665
Query: 576 PTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPA 635
P+ A S + + L LQQ+ QQ Q + + Q+ QQ ++ Q SV +
Sbjct: 666 PSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGP 725
Query: 636 LPRQGCC 642
P C
Sbjct: 726 SPSPNPC 732
Score = 38.1 bits (87), Expect = 0.031
Identities = 101/464 (21%), Positives = 160/464 (34%), Gaps = 80/464 (17%)
Query: 312 ASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMS 371
A K G TK + + PPP +PP + PPPPP + S
Sbjct: 86 ARKAGKHTKATATAATTTAPPPPPAAPP----AASQAAATAAPPPPPDYHHHHQQHLLNS 141
Query: 372 SNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLP---SPALTQQPQFGPQSSIL 428
SN + G S+ N+AL K SPA +++P +S L
Sbjct: 142 SNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFL 201
Query: 429 --------ANLMSS----TIKTPQGHLMS-ALPAS-------NPGPSPPYRP-EKLSSPG 467
NL + I Q +MS LP S N PS + P L + G
Sbjct: 202 DIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMG 261
Query: 468 LPQQSFTP----QCSLIRSLTPTS-----NLLSQQQQQQQQQQQANVIFKPISSNSSKTL 518
L + P CS T N +Q + +F +++ S +
Sbjct: 262 LKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPM 321
Query: 519 SMIMQQGMASSSPGATEPFTFG------NTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHY 572
S + + M +++ +PF + P E K P ++ PS
Sbjct: 322 SDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQ 381
Query: 573 LQQPT--PTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQ-QMMQQPQRFQRSVA 629
L+ P+ P + + +A ST++ + Q Q Q Q S L Q + Q+ ++ A
Sbjct: 382 LRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAA 441
Query: 630 SDSMPALPRQGCCHLFAWTSAASSVKPQHQHGN--SFTSRQDPQPGDVSPSNITHVDKAC 687
+ A +Q + QHQ N + S P PG
Sbjct: 442 NRQQHARMQQH--------------QQQHQPTNWSALPSSAGPSPG-------------- 473
Query: 688 KLGEARHPQVSLGRQPPSCQALGSESFLPGSSFAHELARVTSSY 731
G+ + P S G+Q S Q+ S +PG + ++V ++Y
Sbjct: 474 PFGQEKIPSPSFGQQTFSPQS----SPMPGVAGGSGQSKVMANY 513
Score = 30.0 bits (66), Expect = 8.5
Identities = 74/369 (20%), Positives = 116/369 (31%), Gaps = 83/369 (22%)
Query: 269 KQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSW 328
+Q PSS AQS P+ PLP+ Q Q++ + G QQ
Sbjct: 661 QQQQQPSSQPAQSLPSQ----PLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQH 716
Query: 329 SGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALL 388
S + P PSP+P C + NT GS S +LL
Sbjct: 717 SVV-----GQNTGPSPSPNP--------------------CSNPNT--GSGYMNSQQSLL 749
Query: 389 SSMTSSSNAALGPAMPYAPEKL--PSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSA 446
+ L + ++L L + PQ I +L + P +
Sbjct: 750 NQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLS----RPPPDYKDQR 805
Query: 447 LPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVI 506
N P+ Y + Q+ S LTP S+LLS
Sbjct: 806 RNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSH------------ 853
Query: 507 FKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQK---------M 557
+ + + GM + P +P T+ T ++ + P++ M
Sbjct: 854 ----GTRMPSLSTAVQNMGMYGNLP-CNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMM 908
Query: 558 PSMPT------------------TSRQ--PSLLHYLQQPTPTQASSATASSTATATLQLQ 597
P PT S+Q P+L H + P + S+ +S TA
Sbjct: 909 PRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWAS 968
Query: 598 QQQQQQQQQ 606
Q+ +QQ+
Sbjct: 969 QEGTSKQQE 977
>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
Length = 1012
Score = 68.2 bits (165), Expect = 3e-11
Identities = 119/510 (23%), Positives = 175/510 (34%), Gaps = 91/510 (17%)
Query: 168 SVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQM 227
S + D + + + + K+++ + + L K + E + D +A +++ K Q
Sbjct: 64 STSSNDSKAETVKKSAKKVKEEASSPLKSNK----RQREKVASDTEEADRTSSKKTKTQE 119
Query: 228 SHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQA 287
+ S E SS S+ ++ + S I STS I SP + + S S Q
Sbjct: 120 ISRPNSPSEGEGESSDSR--SVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQ 177
Query: 288 MLPVALPP---------------------LPVPQWHHAHQLKALAASKQGSATKQQGPTP 326
+ A PP LP P A A QGS T Q P
Sbjct: 178 QMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTP----GPTPSATAVPPQGSPTASQAPNQ 233
Query: 327 SWSGLPP---------PGLSPPYRPVPSPHPPPLPLPPPP---------PPFSPQSLMVS 368
+ P P L P RP PSPHPPP P P PP P +P
Sbjct: 234 PQAPTAPVPHTHIQQAPALHPQ-RP-PSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPP 291
Query: 369 CMSSNTLSGSTLRGSPNAL---------LSSMTSSSNAALG----PAMPYAPEKLPSPAL 415
+L+ P L S A LG A P+ +LP+
Sbjct: 292 LHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQS 351
Query: 416 TQQPQFGPQSSIL--ANLMSSTIKTPQGHLMSALPASNPGPSPPY----RPEKLSSPGLP 469
Q Q P+ L A L IK P + LPA PP+ P +++ P
Sbjct: 352 ALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP 411
Query: 470 QQSFTPQCSLIR-----------SLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTL 518
+ P SL L P S L Q Q+ + P +S+ L
Sbjct: 412 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGL 471
Query: 519 SMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTP 578
+ A P A PF G P++ + P P+ P TS QP
Sbjct: 472 HQV-----APQPPFAQHPFVPGGPPPITP-PTCPSTSTPPAGPGTSAQPP----CSGAAA 521
Query: 579 TQASSATASSTATATLQLQQQQQQQQQQPD 608
+ S A SS T+Q++++ ++P+
Sbjct: 522 SGGSIAGGSSCPLPTVQIKEEALDDAEEPE 551
Score = 42.0 bits (97), Expect = 0.002
Identities = 88/361 (24%), Positives = 121/361 (33%), Gaps = 61/361 (16%)
Query: 80 PNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLLENNPMNGN 139
P+ P L+ +T + G + PS A PPL P + LL P
Sbjct: 264 PHPSPHPPLQPLTGSAGQPSAPSHA-----QPPLHGQGPPGPHSLQAGPLLQHPGPPQ-- 316
Query: 140 IMGSPFVVPQTTEVGLK----GPTVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELD 195
PF +P G P Y +PA LQ Q P P E
Sbjct: 317 ----PFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQS--------QQP-PREQP 363
Query: 196 LEKILGTKPEEPLVLDH----PQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSL 251
L P PL + H P + P P H L+ F+ + + +L
Sbjct: 364 L-------PPAPLAMPHIKPPPTTPIPQLPAPQAH-KHPPHLSGPSPFSMNANLPPPPAL 415
Query: 252 QIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALA 311
+ SS + ++ PS P M QS+ P+ P P + L
Sbjct: 416 KPLSSLS--THHPPSAHPP---PLQLMPQSQ-------PLPSSPAQPPGLTQSQNLPPPP 463
Query: 312 ASKQGSATKQQGPTPSWSGLP-PPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCM 370
AS + Q P P ++ P PG PP P P P PP P S Q C
Sbjct: 464 ASHPPTGLHQVAPQPPFAQHPFVPGGPPPITP---PTCPSTSTPPAGPGTSAQP---PC- 516
Query: 371 SSNTLSGSTLRGSPNALLSSMTSSSNA---ALGPAMPYAPEKLPS--PALTQQPQFGPQS 425
S SG ++ G + L ++ A A P P P + PS P + P QS
Sbjct: 517 SGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQS 576
Query: 426 S 426
+
Sbjct: 577 A 577
>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
Length = 1566
Score = 68.2 bits (165), Expect = 3e-11
Identities = 119/510 (23%), Positives = 175/510 (34%), Gaps = 91/510 (17%)
Query: 168 SVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQM 227
S + D + + + + K+++ + + L K + E + D +A +++ K Q
Sbjct: 618 STSSNDSKAETVKKSAKKVKEEASSPLKSNK----RQREKVASDTEEADRTSSKKTKTQE 673
Query: 228 SHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQA 287
+ S E SS S+ ++ + S I STS I SP + + S S Q
Sbjct: 674 ISRPNSPSEGEGESSDSR--SVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQ 731
Query: 288 MLPVALPP---------------------LPVPQWHHAHQLKALAASKQGSATKQQGPTP 326
+ A PP LP P A A QGS T Q P
Sbjct: 732 QMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTP----GPTPSATAVPPQGSPTASQAPNQ 787
Query: 327 SWSGLPP---------PGLSPPYRPVPSPHPPPLPLPPPP---------PPFSPQSLMVS 368
+ P P L P RP PSPHPPP P P PP P +P
Sbjct: 788 PQAPTAPVPHTHIQQAPALHPQ-RP-PSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPP 845
Query: 369 CMSSNTLSGSTLRGSPNAL---------LSSMTSSSNAALG----PAMPYAPEKLPSPAL 415
+L+ P L S A LG A P+ +LP+
Sbjct: 846 LHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQS 905
Query: 416 TQQPQFGPQSSIL--ANLMSSTIKTPQGHLMSALPASNPGPSPPY----RPEKLSSPGLP 469
Q Q P+ L A L IK P + LPA PP+ P +++ P
Sbjct: 906 ALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP 965
Query: 470 QQSFTPQCSLIR-----------SLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTL 518
+ P SL L P S L Q Q+ + P +S+ L
Sbjct: 966 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGL 1025
Query: 519 SMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTP 578
+ A P A PF G P++ + P P+ P TS QP
Sbjct: 1026 HQV-----APQPPFAQHPFVPGGPPPITP-PTCPSTSTPPAGPGTSAQPP----CSGAAA 1075
Query: 579 TQASSATASSTATATLQLQQQQQQQQQQPD 608
+ S A SS T+Q++++ ++P+
Sbjct: 1076 SGGSIAGGSSCPLPTVQIKEEALDDAEEPE 1105
Score = 42.0 bits (97), Expect = 0.002
Identities = 88/361 (24%), Positives = 121/361 (33%), Gaps = 61/361 (16%)
Query: 80 PNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLLENNPMNGN 139
P+ P L+ +T + G + PS A PPL P + LL P
Sbjct: 818 PHPSPHPPLQPLTGSAGQPSAPSHA-----QPPLHGQGPPGPHSLQAGPLLQHPGPPQ-- 870
Query: 140 IMGSPFVVPQTTEVGLK----GPTVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELD 195
PF +P G P Y +PA LQ Q P P E
Sbjct: 871 ----PFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQS--------QQP-PREQP 917
Query: 196 LEKILGTKPEEPLVLDH----PQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSL 251
L P PL + H P + P P H L+ F+ + + +L
Sbjct: 918 L-------PPAPLAMPHIKPPPTTPIPQLPAPQAH-KHPPHLSGPSPFSMNANLPPPPAL 969
Query: 252 QIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALA 311
+ SS + ++ PS P M QS+ P+ P P + L
Sbjct: 970 KPLSSLS--THHPPSAHPP---PLQLMPQSQ-------PLPSSPAQPPGLTQSQNLPPPP 1017
Query: 312 ASKQGSATKQQGPTPSWSGLP-PPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCM 370
AS + Q P P ++ P PG PP P P P PP P S Q C
Sbjct: 1018 ASHPPTGLHQVAPQPPFAQHPFVPGGPPPITP---PTCPSTSTPPAGPGTSAQP---PC- 1070
Query: 371 SSNTLSGSTLRGSPNALLSSMTSSSNA---ALGPAMPYAPEKLPS--PALTQQPQFGPQS 425
S SG ++ G + L ++ A A P P P + PS P + P QS
Sbjct: 1071 SGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQS 1130
Query: 426 S 426
+
Sbjct: 1131 A 1131
>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
Length = 1566
Score = 68.2 bits (165), Expect = 3e-11
Identities = 119/510 (23%), Positives = 175/510 (34%), Gaps = 91/510 (17%)
Query: 168 SVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQM 227
S + D + + + + K+++ + + L K + E + D +A +++ K Q
Sbjct: 618 STSSNDSKAETVKKSAKKVKEEASSPLKSNK----RQREKVASDTEEADRTSSKKTKTQE 673
Query: 228 SHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQA 287
+ S E SS S+ ++ + S I STS I SP + + S S Q
Sbjct: 674 ISRPNSPSEGEGESSDSR--SVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQ 731
Query: 288 MLPVALPP---------------------LPVPQWHHAHQLKALAASKQGSATKQQGPTP 326
+ A PP LP P A A QGS T Q P
Sbjct: 732 QMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTP----GPTPSATAVPPQGSPTASQAPNQ 787
Query: 327 SWSGLPP---------PGLSPPYRPVPSPHPPPLPLPPPP---------PPFSPQSLMVS 368
+ P P L P RP PSPHPPP P P PP P +P
Sbjct: 788 PQAPTAPVPHTHIQQAPALHPQ-RP-PSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPP 845
Query: 369 CMSSNTLSGSTLRGSPNAL---------LSSMTSSSNAALG----PAMPYAPEKLPSPAL 415
+L+ P L S A LG A P+ +LP+
Sbjct: 846 LHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQS 905
Query: 416 TQQPQFGPQSSIL--ANLMSSTIKTPQGHLMSALPASNPGPSPPY----RPEKLSSPGLP 469
Q Q P+ L A L IK P + LPA PP+ P +++ P
Sbjct: 906 ALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP 965
Query: 470 QQSFTPQCSLIR-----------SLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTL 518
+ P SL L P S L Q Q+ + P +S+ L
Sbjct: 966 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGL 1025
Query: 519 SMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTP 578
+ A P A PF G P++ + P P+ P TS QP
Sbjct: 1026 HQV-----APQPPFAQHPFVPGGPPPITP-PTCPSTSTPPAGPGTSAQPP----CSGAAA 1075
Query: 579 TQASSATASSTATATLQLQQQQQQQQQQPD 608
+ S A SS T+Q++++ ++P+
Sbjct: 1076 SGGSIAGGSSCPLPTVQIKEEALDDAEEPE 1105
Score = 42.0 bits (97), Expect = 0.002
Identities = 88/361 (24%), Positives = 121/361 (33%), Gaps = 61/361 (16%)
Query: 80 PNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLLENNPMNGN 139
P+ P L+ +T + G + PS A PPL P + LL P
Sbjct: 818 PHPSPHPPLQPLTGSAGQPSAPSHA-----QPPLHGQGPPGPHSLQAGPLLQHPGPPQ-- 870
Query: 140 IMGSPFVVPQTTEVGLK----GPTVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELD 195
PF +P G P Y +PA LQ Q P P E
Sbjct: 871 ----PFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQS--------QQP-PREQP 917
Query: 196 LEKILGTKPEEPLVLDH----PQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSL 251
L P PL + H P + P P H L+ F+ + + +L
Sbjct: 918 L-------PPAPLAMPHIKPPPTTPIPQLPAPQAH-KHPPHLSGPSPFSMNANLPPPPAL 969
Query: 252 QIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALA 311
+ SS + ++ PS P M QS+ P+ P P + L
Sbjct: 970 KPLSSLS--THHPPSAHPP---PLQLMPQSQ-------PLPSSPAQPPGLTQSQNLPPPP 1017
Query: 312 ASKQGSATKQQGPTPSWSGLP-PPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCM 370
AS + Q P P ++ P PG PP P P P PP P S Q C
Sbjct: 1018 ASHPPTGLHQVAPQPPFAQHPFVPGGPPPITP---PTCPSTSTPPAGPGTSAQP---PC- 1070
Query: 371 SSNTLSGSTLRGSPNALLSSMTSSSNA---ALGPAMPYAPEKLPS--PALTQQPQFGPQS 425
S SG ++ G + L ++ A A P P P + PS P + P QS
Sbjct: 1071 SGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQS 1130
Query: 426 S 426
+
Sbjct: 1131 A 1131
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 67.0 bits (162), Expect = 6e-11
Identities = 98/420 (23%), Positives = 159/420 (37%), Gaps = 61/420 (14%)
Query: 79 YPNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLLENNPMNG 138
YP+ + P +GP + +TA P+ I S A +A SL
Sbjct: 2323 YPSSSRTPQAPASANLVGPRSAHATA-------PVNIAGSRTAAALAPASLT-------- 2367
Query: 139 NIMGSPFVVPQTTEVGLKGPTVPY--YEKIN---SVPAVDQELQEL------LEELTKIQ 187
S + P + L P VP YE+++ S P +D+ +T +
Sbjct: 2368 ----SARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSER 2423
Query: 188 DPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVT 247
PSP+ +G P + L+ P +P PS L + + ++
Sbjct: 2424 APSPSSR-----MGQAPSQSLL--PPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLS 2476
Query: 248 GMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQL 307
++ +SS G + S V P S + + + A P AL L + +
Sbjct: 2477 SGAVATTTSSAGDHNGMLSVPAPGV-PHSDVGEPPASTGAQQPSALAALQPAKERRSSSS 2535
Query: 308 KALAASKQGSATKQQGPTPSW--SGLPPPGLSPPYRP------VPSPHPPPLPL-----P 354
+ ++S S++ + S S G S P +P VPSP P P P
Sbjct: 2536 SSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRP 2595
Query: 355 PPPPPF---------SPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPY 405
P P P S S S SS++ S S+ S ++ SS +SSS+++ PA P
Sbjct: 2596 PEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP- 2654
Query: 406 APEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSS 465
P+ LP PA ++P G + S +++ + S + P P P R ++ SS
Sbjct: 2655 GPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSS 2714
Score = 46.2 bits (108), Expect = 1e-04
Identities = 61/320 (19%), Positives = 116/320 (36%), Gaps = 37/320 (11%)
Query: 311 AASKQGSATKQQGPTPS--WSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVS 368
+A Q T ++ P+PS P L PP + P P P FS QS +
Sbjct: 2412 SAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRS--------PVPSAFSDQSRCLI 2463
Query: 369 CMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPE----KLPSPALTQQPQF--- 421
++ +L A +S N L P P + P+ QQP
Sbjct: 2464 AQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAA 2523
Query: 422 ----------GPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQ 471
SS ++ SS+ + + + + G S P +PE ++ +P
Sbjct: 2524 LQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPE-VALKRVPSP 2582
Query: 472 SFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSP 531
+ P+ ++ P ++++ ++ SS+SS + S +SSS
Sbjct: 2583 TPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSS------SSSSSSSSSSSSSSSSSSSSS 2636
Query: 532 GATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTAT 591
++ + ++ P ++PGPQ +P + + P + P S + S +
Sbjct: 2637 SSSSSSSSSSSSPSP---AKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSY 2693
Query: 592 ATLQLQQQQQQQQQQPDHSS 611
+ ++ ++ Q + SS
Sbjct: 2694 SPVERRRPSPQPSPRDQQSS 2713
Score = 40.0 bits (92), Expect = 0.008
Identities = 110/507 (21%), Positives = 178/507 (35%), Gaps = 52/507 (10%)
Query: 255 SSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASK 314
SS S + P+T S + +A + S++ ++ P P+ + L+ L +S+
Sbjct: 2084 SSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSR 2143
Query: 315 QGSATKQQGPTPSWSGLPPPGLSPPYR-PVPSPHPP----------PLPLPPPPPPFSPQ 363
+ QQ G P P + R VP H L PPP S
Sbjct: 2144 TPMSVLQQAGGSMMDG-PGPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAA 2202
Query: 364 SLMVSCMS-SNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPS--PALTQQPQ 420
L + +LR +P A L+S +++AA AM A + P+ A+
Sbjct: 2203 GLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAA---AMNLASARTPAIPTAVNLADS 2259
Query: 421 FGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLI 480
P ++ NL S + A P + P+ ++ G + SL
Sbjct: 2260 RTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPA-------VNLAGARTPAALAALSLT 2312
Query: 481 RSLT-PTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTF 539
S T PT+ + Q AN++ P S++++ +++ + A+ +P +
Sbjct: 2313 GSGTPPTAANYPSSSRTPQAPASANLV-GPRSAHATAPVNIAGSRTAAALAPASLTSARM 2371
Query: 540 GNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQ 599
++ S P + P LL + TP A S + ++ A +
Sbjct: 2372 APALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRM 2431
Query: 600 QQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVKPQHQ 659
Q Q LL QP+ S SD Q C + T A S
Sbjct: 2432 GQAPSQS------LLPPAQDQPRSPVPSAFSD-------QSRCLIAQTTPVAGSQSLSSG 2478
Query: 660 HGNSFTSRQDPQPG--DVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQAL---GSESF 714
+ TS G V + H D +GE P S G Q PS A E
Sbjct: 2479 AVATTTSSAGDHNGMLSVPAPGVPHSD----VGE---PPASTGAQQPSALAALQPAKERR 2531
Query: 715 LPGSSFAHELARVTSSYSTSEAAPWGS 741
SS + + +SS S+S ++ GS
Sbjct: 2532 SSSSSSSSSSSSSSSSSSSSSSSSSGS 2558
Score = 38.5 bits (88), Expect = 0.024
Identities = 57/250 (22%), Positives = 93/250 (37%), Gaps = 43/250 (17%)
Query: 218 STTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSS 277
STTP P + +H + A S +S S+ S + +T ++ PS + +
Sbjct: 250 STTPAPKSRRAHRSTSADSAS-SSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDA 308
Query: 278 MAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLS 337
P + P Q ++ K K+ SAT+ P+PS
Sbjct: 309 PFSEPGTTSTQRPSS-PETATKQPSSPYEDKD-KDKKEKSATR---PSPS---------- 353
Query: 338 PPYRPVPSPHPP-PLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSN 396
P R P PP P PL SPQ L + +S ++ S ++
Sbjct: 354 -PERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPP--------------SEAS 398
Query: 397 AALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSP 456
+ P +PEKLP + ++ PQ + ++ SS+ ++P+ P P+P
Sbjct: 399 PTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPK-----------PAPAP 447
Query: 457 PYRPEKLSSP 466
E SSP
Sbjct: 448 GSHREISSSP 457
Score = 32.3 bits (72), Expect = 1.7
Identities = 72/310 (23%), Positives = 116/310 (37%), Gaps = 33/310 (10%)
Query: 241 SSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKS---QVQAMLPVALPPLP 297
S SQ S P S S S P ++ +PS S S +V++ P +
Sbjct: 799 SGSSQPKAKSRTPPRRSR--SSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSIT 856
Query: 298 VPQWHHAH---QLKALAASKQGSATKQQGPTP-SWSGLPPPGLSPPYRPVPSPHPPPLPL 353
PQ + Q ++ S K + P+ S SG PP + P SP P
Sbjct: 857 SPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQ 916
Query: 354 PPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSP 413
P SP+ S SS + S T R +P S++ SN Y+ SP
Sbjct: 917 PKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRR-SRSVSPCSNVESRLLPRYSHSGSSSP 975
Query: 414 ALTQQPQFGPQSSILANLM---SSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQ 470
+P+ P+ S ++ +TP G P+ + SP P++ S L Q
Sbjct: 976 DTKVKPETPPRQSHSGSISPYPKVKAQTPPG------PSLSGSKSP--CPQEKSKDSLVQ 1027
Query: 471 Q--SFTPQCSLIRSLTP-------TSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMI 521
C+ ++S TP S+L + Q Q +++ + + S++ S+
Sbjct: 1028 SCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSL- 1086
Query: 522 MQQGMASSSP 531
Q + +SP
Sbjct: 1087 --QSKSQTSP 1094
Score = 32.3 bits (72), Expect = 1.7
Identities = 87/418 (20%), Positives = 135/418 (32%), Gaps = 60/418 (14%)
Query: 223 PSVQMSHLESLAS---SKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMA 279
PS+ M + +S S E + + GMS S S+ + ++P T + S S+S
Sbjct: 1367 PSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSN-QSISSPVLDAVPRTPSRERSSSASSP 1425
Query: 280 QSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPP 339
+ K LP P + S S G +P +P
Sbjct: 1426 EMKD--------GLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGR 1477
Query: 340 YRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAAL 399
SP P LP P P SP SS L+ L +P S SS +
Sbjct: 1478 SECDSSPEPKALPQTPRPRSRSP--------SSPELNNKCL--TPQRERSGSESSVDQKT 1527
Query: 400 GPAMPYAPEKL--PSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALP---ASNPGP 454
P S L +P PQ S + +P + P S G
Sbjct: 1528 VARTPLGQRSRSGSSQELDVKPSASPQE------RSESDSSPDSKAKTRTPLRQRSRSGS 1581
Query: 455 SPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNS 514
SP + SP + +P+ P + S + + + + S +S
Sbjct: 1582 SPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSS 1641
Query: 515 SKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQ 574
SK G S G++ + P S + G + P T SR
Sbjct: 1642 SK--------GRGPSPEGSSSTESSPEHPPKSR-TARRGSRSSPEPKTKSR--------- 1683
Query: 575 QPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDS 632
TP + S+ +S T +L ++ + P+ S + P R +RS + S
Sbjct: 1684 --TPPRRRSSRSSPELTRKARLSRRSRSASSSPETRS-------RTPPRHRRSPSVSS 1732
>gi|55750053 atrophin-1 [Homo sapiens]
Length = 1190
Score = 66.6 bits (161), Expect = 8e-11
Identities = 149/635 (23%), Positives = 210/635 (33%), Gaps = 162/635 (25%)
Query: 63 RQEEDHFQ-FPDMADGGYPNKIKRPCLEDVTLAMG-----PGAHPSTACAELQVPPLTIN 116
RQ E F+ P + GY ++ P G P +P L PP+
Sbjct: 177 RQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPK 236
Query: 117 PSPAAMGVAGQSLLLENNP-------MNGNIMGSPFVVPQTTEVGLKGPTVPYYEKINSV 169
AA V G + ++ P + G+P P TT VG G +P +
Sbjct: 237 GGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVG--GGNLPSAPPPANF 294
Query: 170 PAVDQELQE--LLEELTKIQ--------DPSPNELDLEKILGTK-------PEE-PLVLD 211
P V L L L P P L +G PE+ P +
Sbjct: 295 PHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAP 354
Query: 212 HPQA---TLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSI---P 265
P + S+ P P ++ + S +SS +SS S + + P+S SY P
Sbjct: 355 SPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPP 414
Query: 266 STSKQIVSPSSSMAQSKSQVQAMLPVALPPLP---------------------------- 297
TS + + Q QA+ PP P
Sbjct: 415 PTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHP 474
Query: 298 -VPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSP------------PYRPVP 344
V HH HQ + +Q +QQ SG PPPG P PY P
Sbjct: 475 PVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSP 534
Query: 345 S-----PHPP-PLPLPPPPPPFS-----PQSLMVSCMSSNTLSGSTLRGSPNALLSSMTS 393
S P+PP P LPPP S P VS SS+ S ST +GS S S
Sbjct: 535 SLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVS--SSSNSSSSTSQGS---YPCSHPS 589
Query: 394 SSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPG 453
S G P+ P P S+ L+ ++++ +P G+ AS PG
Sbjct: 590 PSQGPQGAPYPFPP----------VPTVTTSSATLSTVIATVASSPAGY----KTASPPG 635
Query: 454 PSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSN 513
P PPY ++ SPG ++ TP +KP S
Sbjct: 636 P-PPY-GKRAPSPG-----------AYKTATPPG-------------------YKPGSPP 663
Query: 514 SSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYL 573
S +T T P G + P +PG + P PS L L
Sbjct: 664 SFRT---------------GTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSL 708
Query: 574 QQPTPTQASSATASSTATATLQLQQQQQQQQQQPD 608
P AS S+T Q++Q+ ++ + P+
Sbjct: 709 PPPPAAPASGPPLSAT-----QIKQEPAEEYETPE 738
Score = 48.5 bits (114), Expect = 2e-05
Identities = 132/576 (22%), Positives = 188/576 (32%), Gaps = 95/576 (16%)
Query: 241 SSCSQVTGMSLQIPSSST--GISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPV 298
S + G SL SS I STS I SP S S S A P P
Sbjct: 103 SDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPP 162
Query: 299 PQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPP--YRPVPSPHPPPLPLPPP 356
P + + Q +T +Q P S P P ++P + P+ P PP
Sbjct: 163 PLFPPSPQ--------PPDSTPRQ---PEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPG 211
Query: 357 PPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALT 416
PP PQ + + LSG + SS+ + P P P + S +
Sbjct: 212 APPPHPQ--LYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPP-PTTPISVSSSGAS 268
Query: 417 QQPQFGPQSSILA--NLMSSTIKTPQGHLMSALPASNPGPSPPYRP---EKLSSPGLPQQ 471
P P ++ + NL S+ H+ LP P P RP S PGL Q
Sbjct: 269 GAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLP-----PPPALRPLNNASASPPGLGAQ 323
Query: 472 SFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSN----------SSKTLSMI 521
++ L ++ + P SS+ SS + S
Sbjct: 324 PLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSA 383
Query: 522 MQQGMASSSPGATEPFTFGNTKP-LSHFVSEPGPQKMPSMPTTSRQPSLLH---YLQQPT 577
+SSS + PF P H P + + P QPSL + Q P
Sbjct: 384 AASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPP 443
Query: 578 P--------------------TQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQM 617
P + + +TA + QQQQQQQQQ QQ
Sbjct: 444 PPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQ-------QQQ 496
Query: 618 MQQPQRFQRSVASDSMPALPR------QGCCHLFAWTSAASSVKP--------QHQHGNS 663
QQ Q+ + A P H +A + + S++P H
Sbjct: 497 QQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQV 556
Query: 664 FTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQ------PPSCQALGSESFLPG 717
S+ P VS S+ + + HP S G Q PP S + L
Sbjct: 557 SYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATL-- 614
Query: 718 SSFAHELARVTSSYSTSEAAPWGSWDPKAWRQVPAP 753
S+ +A + Y T A+P G P ++ P+P
Sbjct: 615 STVIATVASSPAGYKT--ASPPG--PPPYGKRAPSP 646
Score = 39.7 bits (91), Expect = 0.011
Identities = 54/219 (24%), Positives = 72/219 (32%), Gaps = 31/219 (14%)
Query: 253 IPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAML------------PVALPPLPVPQ 300
+P + +SYS + VS SS+ + S SQ P PP+P
Sbjct: 549 LPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVT 608
Query: 301 WHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPF 360
A +A A + PPG P + PSP PP P
Sbjct: 609 TSSATLSTVIATVASSPA--------GYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPG 660
Query: 361 SPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPS-PALTQQP 419
SP S + T G P + S GP P P LPS P P
Sbjct: 661 SPPS-----FRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAP 715
Query: 420 QFGPQSSI--LANLMSSTIKTPQGHLMSALPASNPGPSP 456
GP S + + +TP+ + PA +P P P
Sbjct: 716 ASGPPLSATQIKQEPAEEYETPESPVP---PARSPSPPP 751
>gi|55750041 atrophin-1 [Homo sapiens]
Length = 1190
Score = 66.6 bits (161), Expect = 8e-11
Identities = 149/635 (23%), Positives = 210/635 (33%), Gaps = 162/635 (25%)
Query: 63 RQEEDHFQ-FPDMADGGYPNKIKRPCLEDVTLAMG-----PGAHPSTACAELQVPPLTIN 116
RQ E F+ P + GY ++ P G P +P L PP+
Sbjct: 177 RQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPK 236
Query: 117 PSPAAMGVAGQSLLLENNP-------MNGNIMGSPFVVPQTTEVGLKGPTVPYYEKINSV 169
AA V G + ++ P + G+P P TT VG G +P +
Sbjct: 237 GGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVG--GGNLPSAPPPANF 294
Query: 170 PAVDQELQE--LLEELTKIQ--------DPSPNELDLEKILGTK-------PEE-PLVLD 211
P V L L L P P L +G PE+ P +
Sbjct: 295 PHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAP 354
Query: 212 HPQA---TLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSI---P 265
P + S+ P P ++ + S +SS +SS S + + P+S SY P
Sbjct: 355 SPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPP 414
Query: 266 STSKQIVSPSSSMAQSKSQVQAMLPVALPPLP---------------------------- 297
TS + + Q QA+ PP P
Sbjct: 415 PTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHP 474
Query: 298 -VPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSP------------PYRPVP 344
V HH HQ + +Q +QQ SG PPPG P PY P
Sbjct: 475 PVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSP 534
Query: 345 S-----PHPP-PLPLPPPPPPFS-----PQSLMVSCMSSNTLSGSTLRGSPNALLSSMTS 393
S P+PP P LPPP S P VS SS+ S ST +GS S S
Sbjct: 535 SLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVS--SSSNSSSSTSQGS---YPCSHPS 589
Query: 394 SSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPG 453
S G P+ P P S+ L+ ++++ +P G+ AS PG
Sbjct: 590 PSQGPQGAPYPFPP----------VPTVTTSSATLSTVIATVASSPAGY----KTASPPG 635
Query: 454 PSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSN 513
P PPY ++ SPG ++ TP +KP S
Sbjct: 636 P-PPY-GKRAPSPG-----------AYKTATPPG-------------------YKPGSPP 663
Query: 514 SSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYL 573
S +T T P G + P +PG + P PS L L
Sbjct: 664 SFRT---------------GTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSL 708
Query: 574 QQPTPTQASSATASSTATATLQLQQQQQQQQQQPD 608
P AS S+T Q++Q+ ++ + P+
Sbjct: 709 PPPPAAPASGPPLSAT-----QIKQEPAEEYETPE 738
Score = 48.5 bits (114), Expect = 2e-05
Identities = 132/576 (22%), Positives = 188/576 (32%), Gaps = 95/576 (16%)
Query: 241 SSCSQVTGMSLQIPSSST--GISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPV 298
S + G SL SS I STS I SP S S S A P P
Sbjct: 103 SDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPP 162
Query: 299 PQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPP--YRPVPSPHPPPLPLPPP 356
P + + Q +T +Q P S P P ++P + P+ P PP
Sbjct: 163 PLFPPSPQ--------PPDSTPRQ---PEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPG 211
Query: 357 PPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALT 416
PP PQ + + LSG + SS+ + P P P + S +
Sbjct: 212 APPPHPQ--LYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPP-PTTPISVSSSGAS 268
Query: 417 QQPQFGPQSSILA--NLMSSTIKTPQGHLMSALPASNPGPSPPYRP---EKLSSPGLPQQ 471
P P ++ + NL S+ H+ LP P P RP S PGL Q
Sbjct: 269 GAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLP-----PPPALRPLNNASASPPGLGAQ 323
Query: 472 SFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSN----------SSKTLSMI 521
++ L ++ + P SS+ SS + S
Sbjct: 324 PLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSA 383
Query: 522 MQQGMASSSPGATEPFTFGNTKP-LSHFVSEPGPQKMPSMPTTSRQPSLLH---YLQQPT 577
+SSS + PF P H P + + P QPSL + Q P
Sbjct: 384 AASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPP 443
Query: 578 P--------------------TQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQM 617
P + + +TA + QQQQQQQQQ QQ
Sbjct: 444 PPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQ-------QQQ 496
Query: 618 MQQPQRFQRSVASDSMPALPR------QGCCHLFAWTSAASSVKP--------QHQHGNS 663
QQ Q+ + A P H +A + + S++P H
Sbjct: 497 QQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQV 556
Query: 664 FTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQ------PPSCQALGSESFLPG 717
S+ P VS S+ + + HP S G Q PP S + L
Sbjct: 557 SYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATL-- 614
Query: 718 SSFAHELARVTSSYSTSEAAPWGSWDPKAWRQVPAP 753
S+ +A + Y T A+P G P ++ P+P
Sbjct: 615 STVIATVASSPAGYKT--ASPPG--PPPYGKRAPSP 646
Score = 39.7 bits (91), Expect = 0.011
Identities = 54/219 (24%), Positives = 72/219 (32%), Gaps = 31/219 (14%)
Query: 253 IPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAML------------PVALPPLPVPQ 300
+P + +SYS + VS SS+ + S SQ P PP+P
Sbjct: 549 LPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVT 608
Query: 301 WHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPF 360
A +A A + PPG P + PSP PP P
Sbjct: 609 TSSATLSTVIATVASSPA--------GYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPG 660
Query: 361 SPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPS-PALTQQP 419
SP S + T G P + S GP P P LPS P P
Sbjct: 661 SPPS-----FRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAP 715
Query: 420 QFGPQSSI--LANLMSSTIKTPQGHLMSALPASNPGPSP 456
GP S + + +TP+ + PA +P P P
Sbjct: 716 ASGPPLSATQIKQEPAEEYETPESPVP---PARSPSPPP 751
>gi|56549696 E1A binding protein p400 [Homo sapiens]
Length = 3122
Score = 65.1 bits (157), Expect = 2e-10
Identities = 96/378 (25%), Positives = 138/378 (36%), Gaps = 89/378 (23%)
Query: 293 LPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLP 352
LPP+ V + + +A K+ A +Q+ P+ + PPP PP P P PPPLP
Sbjct: 2472 LPPIQVASL----RAERIAKEKKALADQQKAQQPAVAQPPPPQPQPP--PPPQQPPPPLP 2525
Query: 353 LP------PP--PPPFSPQ-------------------------------------SLMV 367
P PP PP PQ S+
Sbjct: 2526 QPQAAGSQPPAGPPAVQPQPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTG 2585
Query: 368 SCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPA--------LTQQP 419
+ M + +SG+ + + + ++ S N L A P AP L +P TQ P
Sbjct: 2586 TSMPTGAVSGNVIVNTIAGVPAATFQSINKRL--ASPVAPGALTTPGGSAPAQVVHTQPP 2643
Query: 420 QFGPQSSILANLMSSTIKTPQG-HLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCS 478
S A ++ T QG ++++ AS + L+ P +S PQ S
Sbjct: 2644 PRAVGSPATATPDLVSMATTQGVRAVTSVTASAVVTT------NLTPVQTPARSLVPQVS 2697
Query: 479 LI-------RSLTPTS-NLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSS 530
+++TP LL QQQQQQQQQQQ + QQ +++
Sbjct: 2698 QATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQ------QQQQQQQQQQQQQQQQTTTT 2751
Query: 531 PGATEPFTFGNTKPLSHF--VSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASS 588
P G + + V + P+ + M Q L QP P QA SA
Sbjct: 2752 SQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKM-----QKQKLQMPPQPPPPQAQSAPPQP 2806
Query: 589 TATATLQLQQQQQQQQQQ 606
TA +Q Q QQQ Q
Sbjct: 2807 TAQVQVQTSQPPQQQSPQ 2824
Score = 45.8 bits (107), Expect = 2e-04
Identities = 104/439 (23%), Positives = 158/439 (35%), Gaps = 55/439 (12%)
Query: 204 PEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYS 263
P LV QAT P ++ +H + L ++ Q Q
Sbjct: 2688 PARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 2747
Query: 264 IPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQG 323
+TS+ V AQS +Q++A V + H +K KQ K Q
Sbjct: 2748 TTTTSQVQVPQIQGQAQSPAQIKA----------VGKLTPEHLIKM---QKQ----KLQM 2790
Query: 324 PTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNT-LSGSTLRG 382
P PPP + P P+ + PP SPQ V+ L+G+T+
Sbjct: 2791 PPQ-----PPPPQAQSAPPQPTAQ-VQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVAN 2844
Query: 383 SPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGH 442
A L+ + +S A G AP+ P+ +P P S+ A ++SS T
Sbjct: 2845 LQVARLTRVPTSQLQAQGQMQTQAPQ--PAQVALAKP---PVVSVPAAVVSSPGVT---- 2895
Query: 443 LMSALPASNPGPSPPY-RPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQ 501
LP + G S +P+K + + Q Q L L QQ QQQ+
Sbjct: 2896 ---TLPMNVAGISVAIGQPQKAAGQTVVAQPVHMQQLL---------KLKQQAVQQQKAI 2943
Query: 502 QANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPF--TFGNTKPLSHFVSEPGPQKMPS 559
Q P + T I G A +P T T P+S G Q++ +
Sbjct: 2944 QPQAAQGPAAVQQKITAQQITTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQT 3003
Query: 560 MPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQ----LQQQQQQQQQQPDHSSFLLQ 615
++ P + +QQ TP + AS++ A+ Q Q QQ Q +
Sbjct: 3004 QIQVAKLPQV---VQQQTPVASIQQVASASQQASPQTVALTQATAAGQQVQMIPAVTATA 3060
Query: 616 QMMQQPQRFQRSVASDSMP 634
Q++QQ Q+ V + S P
Sbjct: 3061 QVVQQKLIQQQVVTTASAP 3079
Score = 38.5 bits (88), Expect = 0.024
Identities = 56/206 (27%), Positives = 78/206 (37%), Gaps = 36/206 (17%)
Query: 289 LPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHP 348
LP LPP VP A AL ++Q + Q P P P+P+P
Sbjct: 556 LPGRLPPAGVPT---AALSSALQFAQQPQVVEAQTQLQI-----PVKTQQPNVPIPAPPS 607
Query: 349 PPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSS-------------MTSSS 395
LP+PP P + +L V + S L P + S+ + +SS
Sbjct: 608 SQLPIPPSQP--AQLALHVPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSS 665
Query: 396 NAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPS 455
++L P P PSPA P P S+ L T +TP G + SA P+
Sbjct: 666 TSSLAPVSGSGPG--PSPA-RSSPVNRPSSATNKALSPVTSRTP-GVVASA-------PT 714
Query: 456 PPYRPEK--LSSPGLPQQSFTPQCSL 479
P P + SS Q + T Q +L
Sbjct: 715 KPQSPAQNATSSQDSSQDTLTEQITL 740
Score = 36.6 bits (83), Expect = 0.091
Identities = 77/335 (22%), Positives = 120/335 (35%), Gaps = 66/335 (19%)
Query: 342 PVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGP 401
P PSP P P P P SP + M+ + +G + + ++ + + L P
Sbjct: 34 PPPSPAAPFAPSASPSAPQSPSYQIQQLMNRSPATGQNVNITLQSVGPVVGGNQQITLAP 93
Query: 402 AMPYAPEKLPSPALTQQP---QFGPQSSI-LANLMSSTIKTPQGHLMSALPASNPGPSPP 457
+P P + QP + G S I + + +S ++T + +PGP
Sbjct: 94 -LPLPSPTSPGFQFSAQPRRFEHGSPSYIQVTSPLSQQVQT------QSPTQPSPGPGQA 146
Query: 458 YRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKT 517
+ + +PG P L S +PT + A+V+ + IS + S
Sbjct: 147 LQNVRAGAPG-------PGLGLCSS-SPTGGFV-----------DASVLVRQISLSPSSG 187
Query: 518 LSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGP-----QKMPSMPTTSRQPSLLHY 572
+ Q G G T+ G L H PG ++ PS P T + +H+
Sbjct: 188 GHFVFQDG-----SGLTQ-IAQGAQVQLQH----PGTPITVRERRPSQPHT-QSGGTIHH 236
Query: 573 LQQPTPTQASSA----TASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQ--- 625
L +P A A AS + T L P SS + Q++QQ Q Q
Sbjct: 237 LGPQSPAAAGGAGLQPLASPSHITTANL---------PPQISSIIQGQLVQQQQVLQGPP 287
Query: 626 --RSVASDSMPA--LPRQGCCHLFAWTSAASSVKP 656
R + + P LP G F TS P
Sbjct: 288 LPRPLGFERTPGVLLPGAGGAAGFGMTSPPPPTSP 322
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 64.7 bits (156), Expect = 3e-10
Identities = 84/314 (26%), Positives = 115/314 (36%), Gaps = 60/314 (19%)
Query: 308 KALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSL-- 365
+A+A +A K++ P PP PP P PS PPP PPPPPP SP L
Sbjct: 384 RAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPS 443
Query: 366 ----------MVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPAL 415
S + S RG P S A GP P PS A
Sbjct: 444 PPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTAT 503
Query: 416 TQQPQFGP-----QSSILANL-----------MSSTIKTPQGHLMSALPASNP--GPSPP 457
P+ P ++ L N+ S IKTP+ M P P SP
Sbjct: 504 GGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPR-RFMDEDPPKPPKVEVSPV 562
Query: 458 YRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKT 517
RP +SP +PQ+ P S R+ TP S + ++++ +++ +P +S T
Sbjct: 563 LRPPITTSPPVPQEP-APVPSPPRAPTPPSTPVPLPEKRR------SILREPTFRWTSLT 615
Query: 518 LSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPT 577
+ P A P P P P+ T+SR+P LL Q T
Sbjct: 616 REL-------PPPPPAPPP--------------PPAPSPPPAPATSSRRPLLLR-APQFT 653
Query: 578 PTQASSATASSTAT 591
P++A S T
Sbjct: 654 PSEAHLKIYESVLT 667
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/287 (26%), Positives = 108/287 (37%), Gaps = 51/287 (17%)
Query: 290 PVALPPLPVPQWHHAHQLKALAA---SKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSP 346
PV P PVP A + K+ S ++ PT W+ L PP P+P
Sbjct: 572 PVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILRE--PTFRWTSLTRELPPPP----PAP 625
Query: 347 HPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYA 406
PPP P PPP P S + ++ T S + L+ + L + LG P A
Sbjct: 626 PPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVL-------TPPPLG--APEA 676
Query: 407 PEKLPSPALTQQPQFGPQSSILANLMS-----STIKTPQGHLMS--ALPASNPGPSPPYR 459
PE P PA + P++ N +S + TP +S PA + GP +
Sbjct: 677 PEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQ 736
Query: 460 ----PEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSS 515
+ L + LPQ PQ L +P QQ ++ + A V P+S
Sbjct: 737 LLQPLQALQTQLLPQALPPPQPQLQPPPSP------QQMPPLEKARIAGVGSLPLSGVEE 790
Query: 516 KTLSMI-------------MQQGMASS---SPGATEPFTFGNTKPLS 546
K S++ QQ +A+S SPG G K +S
Sbjct: 791 KMFSLLKRAKVQLFKIDQQQQQKVAASMPLSPGGQMEEVAGAVKQIS 837
Score = 41.2 bits (95), Expect = 0.004
Identities = 96/422 (22%), Positives = 137/422 (32%), Gaps = 80/422 (18%)
Query: 334 PGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTS 393
P L PP P P P+P PP +P S V S LR P +S+T
Sbjct: 561 PVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRR---SILR-EPTFRWTSLTR 616
Query: 394 S-SNAALGPAMPYAPEKLPSPA-------LTQQPQFGPQSSILANLMSSTIKTPQGHLMS 445
P P AP P+PA L + PQF P + L S P G +
Sbjct: 617 ELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEA 676
Query: 446 ALPASNPGPSPPYRPE-----KLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQ 500
P P P PE + + LP+ F P + TP +S
Sbjct: 677 PEPEPPPADDSPAEPEPRAVGRTNHLSLPR--FAPVVT-----TPVKAEVSPHG------ 723
Query: 501 QQANVIFKPISSNSSKTLSMIMQQGMASSS---PGATEPFTFGNTKPLSHFVSEPGPQKM 557
P SN +T + ++Q A + P A P P P PQ+M
Sbjct: 724 -------APALSNGPQTQAQLLQPLQALQTQLLPQALPP-------PQPQLQPPPSPQQM 769
Query: 558 PSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQM 617
P + + + + + + S A +QL + QQQQQ+
Sbjct: 770 PPL-----EKARIAGVGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQQQK----------- 813
Query: 618 MQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQPGDVSP 677
+ SMP P + S P S ++++ G SP
Sbjct: 814 -----------VAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESP 862
Query: 678 SNITHVDKACKLGEARHPQVSLGRQPPSC-QALGSESFLPGSSFAHELARVTSSYSTSEA 736
+ C RH V+LG+ + + S LP TSS S +E+
Sbjct: 863 VQGPRIKHVC-----RHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETES 917
Query: 737 AP 738
P
Sbjct: 918 VP 919
Score = 36.2 bits (82), Expect = 0.12
Identities = 44/149 (29%), Positives = 55/149 (36%), Gaps = 36/149 (24%)
Query: 346 PHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPY 405
P PPP+ PP PP SP + +S TL P LL + +G P
Sbjct: 2210 PVPPPVKQPPLPPTISP-----TAPTSWTL-------PPGPLLGVL-----PVVGVVRPA 2252
Query: 406 APEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSS 465
P P P LT GP S + + T G S P P PPY+ +L
Sbjct: 2253 PPP--PPPPLTLVLSSGPASPPRQAIRVKRVSTFSGR-------SPPAP-PPYKAPRLDE 2302
Query: 466 PGLPQQSFTPQC--------SLIRSLTPT 486
G + TPQ S +R TPT
Sbjct: 2303 DGEASED-TPQVPGLGSGGFSRVRMKTPT 2330
Score = 33.5 bits (75), Expect = 0.77
Identities = 52/186 (27%), Positives = 75/186 (40%), Gaps = 52/186 (27%)
Query: 325 TPSWSGLPPPGLSPP-------------YRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMS 371
+P+ S PP G PP + P+ + PP P PP +P+S
Sbjct: 1807 SPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRS------- 1859
Query: 372 SNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANL 431
SG+ ++ PN S S LG + + P LPSP G SS+ ++
Sbjct: 1860 ---FSGARIK-VPN------YSPSRRPLG-GVSFGP--LPSP--------GSPSSLTHHI 1898
Query: 432 MSSTIKTPQGHLMSALPASNPGPS---PPYRPEKLSSPGL---PQQSFTPQCSLIRSLTP 485
T+ P A P + PS P P + +SP L PQ P S++ +LTP
Sbjct: 1899 --PTVGDPD---FPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTP 1953
Query: 486 TSNLLS 491
TS L+
Sbjct: 1954 TSGELA 1959
Score = 32.3 bits (72), Expect = 1.7
Identities = 28/95 (29%), Positives = 33/95 (34%), Gaps = 15/95 (15%)
Query: 290 PVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPP 349
PV PPLP S + P P LP G+ RP P P PP
Sbjct: 2214 PVKQPPLPP------------TISPTAPTSWTLPPGPLLGVLPVVGV---VRPAPPPPPP 2258
Query: 350 PLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSP 384
PL L P SP + +T SG + P
Sbjct: 2259 PLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPP 2293
Score = 31.2 bits (69), Expect = 3.8
Identities = 45/199 (22%), Positives = 69/199 (34%), Gaps = 38/199 (19%)
Query: 176 LQELLEELTKIQDPSPNE---------LDLEKILGTKPEE--PLV-LDHPQATLSTTPKP 223
L+ E T + P+P+ LD + ++ PE P+ LD P S + P
Sbjct: 1795 LEAAEENQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPP 1854
Query: 224 SVQMSHLESLASSKEFASSCSQVTGMS---LQIPSSSTGISYSIPSTSKQIVSPSSSMAQ 280
S + ++ S + G+S L P S + +++ IP+ P
Sbjct: 1855 PAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVG----DPDFPAPP 1910
Query: 281 SKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPY 340
+S+ P L P P P + LK +P PP +
Sbjct: 1911 RRSR----RPSPLAPRPPPSRWASPPLKT---------------SPQLRVPPPTSVVTAL 1951
Query: 341 RPVPSPHPPPLPLPPPPPP 359
P PP P P PPPP
Sbjct: 1952 TPTSGELAPPGPAPSPPPP 1970
Score = 30.8 bits (68), Expect = 5.0
Identities = 21/57 (36%), Positives = 25/57 (43%), Gaps = 21/57 (36%)
Query: 331 LPPPGLSPPYRPVPSPHPP--------PL-----------PLPPPPPPFSPQSLMVS 368
+PPP PP P SP P PL P PPPPPP P +L++S
Sbjct: 2211 VPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPP--PLTLVLS 2265
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 63.2 bits (152), Expect = 9e-10
Identities = 121/524 (23%), Positives = 169/524 (32%), Gaps = 81/524 (15%)
Query: 164 EKINSVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKP 223
EK+ V + Q + L K +P E+D E + KP L+ T K
Sbjct: 628 EKLGRVVHIIQSREPSL----KNSNPDEIEIDFETL---KPSTLRELER-YVTSCLRKKR 679
Query: 224 SVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKS 283
Q ++ +A S S++ G S SS+ S S S+ ++P S
Sbjct: 680 KPQAEKVDVIAGS-------SKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPG 732
Query: 284 QVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPV 343
+ Q HH HQ QQ P P PPP PP P
Sbjct: 733 REQKK-----------HHHHHHQ------------QMQQAPAPVPQQPPPPPQQPPPPPP 769
Query: 344 PSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTL-----RGSPNALLSSMTSSSNAA 398
P P P PPPPP PQ + SS +T P ++ + +
Sbjct: 770 PQQQQQPPP--PPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPI 827
Query: 399 LGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPY 458
L P P LP P P+ S +L + +P L +AL P P
Sbjct: 828 LHLPQPELPPHLPQP---------PEHSTPPHLNQHAVVSPPA-LHNAL------PQQPS 871
Query: 459 RPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTL 518
RP ++ P+ + P S + TP LL Q Q Q P +S +
Sbjct: 872 RPSNRAAALPPKPARPPAVSPALTQTP---LLPQPPMAQPPQVLLEDEEPPAPPLTSMQM 928
Query: 519 SMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGP--------QKMPSMPTTSRQPSLL 570
+ +QQ P P ++P P P Q P P + P
Sbjct: 929 QLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQ 988
Query: 571 HYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVAS 630
+ P P S+ +QQ Q QQP H Q QP + Q+ +
Sbjct: 989 QHQPPPRPVHLQPMQFST------HIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQH 1042
Query: 631 DSMPALPRQ---GCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQ 671
P + HL S PQ S T + PQ
Sbjct: 1043 HHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQ 1086
Score = 50.4 bits (119), Expect = 6e-06
Identities = 49/202 (24%), Positives = 67/202 (33%), Gaps = 35/202 (17%)
Query: 274 PSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPP 333
P Q + Q Q P P P PQ H + + +T Q P P P
Sbjct: 961 PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPP------P 1014
Query: 334 PGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTS 393
G PP HPPP PPPP P PQ ++ SP S S
Sbjct: 1015 QGQQPP-------HPPPGQQPPPPQPAKPQQVIQH------------HHSPRHHKSDPYS 1055
Query: 394 SSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPG 453
+ + + PSP + PQ S+ P+ + A P
Sbjct: 1056 TGHL----------REAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQ 1105
Query: 454 PSPPYRPEKLSSPGLPQQSFTP 475
P + EK+ SP + + F+P
Sbjct: 1106 PLVVVKEEKIHSPIIRSEPFSP 1127
Score = 45.4 bits (106), Expect = 2e-04
Identities = 85/373 (22%), Positives = 128/373 (34%), Gaps = 68/373 (18%)
Query: 204 PEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYS 263
P+ L PQ +TP Q + + A S+ + + +P
Sbjct: 831 PQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAV 890
Query: 264 IPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQG 323
P+ ++ + P MAQ Q +L PP P + Q++ Q K Q
Sbjct: 891 SPALTQTPLLPQPPMAQPP---QVLLEDEEPPAPPLT---SMQMQLYLQQLQ----KVQP 940
Query: 324 PTPSWSGL-----PPPGLSPPYRPV--------PSPHPPPLPLPPPPPPFSPQSLMVSCM 370
PTP + PPP L PP P P P PPP P PPP P V
Sbjct: 941 PTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVH-- 998
Query: 371 SSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILAN 430
L M S++ P P ++ P P QQP P
Sbjct: 999 -----------------LQPMQFSTHIQQPP--PPQGQQPPHPPPGQQPP--PPQPAKPQ 1037
Query: 431 LMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLL 490
+ +P+ H S PY L P +PQ S +SLT S
Sbjct: 1038 QVIQHHHSPRHH-----------KSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQ 1086
Query: 491 SQQQQQQQQQQQANVIF-KPISSNSSKTLSMIMQQGMASSSPGATEPFTFG-NTKPLSHF 548
Q ++Q+ + A+V+ +P+ +++++ S +EPF+ +P H
Sbjct: 1087 QNVQPKKQELRAASVVQPQPL---------VVVKEEKIHSPIIRSEPFSPSLRPEPPKHP 1137
Query: 549 VSEPGPQKMPSMP 561
S P +P P
Sbjct: 1138 ESIKAPVHLPQRP 1150
Score = 38.9 bits (89), Expect = 0.018
Identities = 78/387 (20%), Positives = 140/387 (36%), Gaps = 60/387 (15%)
Query: 267 TSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTP 326
T+K VS + Q+ + Q P PP PV H Q TP
Sbjct: 188 TAKPGVSTVPNTTQASTPPQTQTPQPNPP-PVQATPHPFPAVTPDLIVQ---------TP 237
Query: 327 SWSGLPPPGLSPPYRPVPSPHPPPLPLPPP---PPPF---SPQSLMVS---CMSSNTLSG 377
+ +PP L P P P PPP P P P PP +PQ + ++T +
Sbjct: 238 VMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTP 297
Query: 378 ST---LRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSS 434
+T + P+ T+ + P P K P Q P P+ S + +S
Sbjct: 298 TTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHP--APEKS---SKVSE 352
Query: 435 TIKTPQGHLMSALPASNPGPS-PPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQ- 492
+K G L + + P Y+P + + GL C +I+ S + S+
Sbjct: 353 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHD-----YCDIIKHPMDMSTIKSKL 407
Query: 493 QQQQQQQQQQANVIFKPISSN-------------SSKTLSMIMQQGMASSSPGATEPFTF 539
+ ++ + Q+ + + SN ++ L + + A EP
Sbjct: 408 EAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVA 467
Query: 540 GNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQ 599
++ + P P K+ + P++S S + + + S+T S +L +
Sbjct: 468 VSSPAV------PPPTKVVAPPSSSDSSS-------DSSSDSDSSTDDSEEERAQRLAEL 514
Query: 600 QQQQQQQPDHSSFLLQQMMQQPQRFQR 626
Q+Q + + + L Q +P++ ++
Sbjct: 515 QEQLKAVHEQLAALSQPQQNKPKKKEK 541
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 63.2 bits (152), Expect = 9e-10
Identities = 117/526 (22%), Positives = 173/526 (32%), Gaps = 70/526 (13%)
Query: 72 PDMADGGYPNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLL 131
P + G P K+ T A+ P A C P + + A G L
Sbjct: 737 PSLPPAGTPPGTKKVDGISHTSALAPVASSPKEC------PTEDSGASATASSKGTLTYL 790
Query: 132 ENNPMNGNIMGSPFVVPQTTEVGLKGPTVPYYEKINSVPAVDQELQELLEELTKIQDPSP 191
++P + SP T+ G GP P + V V+ L E Q
Sbjct: 791 ADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASF--LPENSLSFQGSKD 848
Query: 192 NELDLEKILGTKPEEPLVLDHPQATLSTTPK------PSVQMSHLESLASSKEFASSCSQ 245
+ P P P A +PK + +L KE ++ +
Sbjct: 849 SPATTHS---PTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAP 905
Query: 246 VTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAH 305
+L + SSS + + P+ SPS A + P P P P+W
Sbjct: 906 KQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTP 965
Query: 306 QLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVP-SPHPPPLPLPPPPPPFSPQS 364
+ K G AT P+P + PP P + P +P P P PP P SP
Sbjct: 966 PAATPPSPKGGPAT----PSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSP-- 1019
Query: 365 LMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQ 424
+GSP A T A P P SPA T P+ P
Sbjct: 1020 ----------------KGSPAA-----TPFPKGASTPPAATPPSPKGSPAATPLPKGAPT 1058
Query: 425 SSILANLMSSTIKTPQGHLMSALPASNPGPSPPYR--PEKLSSPGLPQQSFTPQCSLIRS 482
+ ++T+ +P+G A P+ P+PP P P P P
Sbjct: 1059 TP------AATLPSPKGG--PATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATP 1110
Query: 483 LTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNT 542
+P L + + A P S L+ +G A ++P AT P G
Sbjct: 1111 PSPKGGLATPPHKGAPTTPAAT----PPSPKGG--LATPPPKG-APTTPAATPPSPKGG- 1162
Query: 543 KPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASS 588
++ P P+ P+ P + PS L P+P A + A++
Sbjct: 1163 ------LATPPPKGAPTTPAAT-PPSPKGGLATPSPKGAPTTPAAT 1201
Score = 45.4 bits (106), Expect = 2e-04
Identities = 76/340 (22%), Positives = 121/340 (35%), Gaps = 43/340 (12%)
Query: 273 SPSSSMAQSKSQVQAMLPVALPP-------LPVPQWHHAHQLKALAASKQGSATKQQGPT 325
SP +A + P A PP P P+ + K G AT
Sbjct: 1181 SPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLAT------ 1234
Query: 326 PSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPN 385
PS G P + P P P PP P PP +P SL L+ +G+PN
Sbjct: 1235 PSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSL------KGGLATPPHKGAPN 1288
Query: 386 ALLSSMTSSSNAALGPAMPYAPEKLPSP--ALTQQPQFGPQSSILANLMSSTIKTPQG-- 441
+ + S GPA P+ P+P A P+ P + + TP
Sbjct: 1289 PAVVTPPSPKG---GPATS-PPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPK 1344
Query: 442 ---HLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQ 498
L + P+S GP+ P E + P + TP ++TP S +
Sbjct: 1345 GTPTLPATTPSSKGGPTTPSSKEGPTPP-----AATPSHKGGPAMTPPSPKRGPAIPSPK 1399
Query: 499 QQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMP 558
+ + P+S + + + ++G A+ S G P L + P+ P
Sbjct: 1400 GDPTSPAVI-PLSPKKAPA-TPVTREGAATPSKGDLTPPAV-TPVSLKKAPATSAPKGGP 1456
Query: 559 SMPTTSRQPSLLHYL-----QQPTPTQASSATASSTATAT 593
+ P++ P+L + P P Q +++++ A AT
Sbjct: 1457 ATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPAT 1496
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/248 (25%), Positives = 92/248 (37%), Gaps = 37/248 (14%)
Query: 263 SIPSTSKQIVSPSSSMA----QSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSA 318
++P+T +++ P + A S V A L P LP P Q SA
Sbjct: 8 TVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPL-------SA 60
Query: 319 TKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPP---------PPFSPQSL-MVS 368
Q P PS S + L P+ S PL P PP SP +L + S
Sbjct: 61 ANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALAS 120
Query: 369 CMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSIL 428
M + TL G+ +P AL++ S + + + P L SP + G ++
Sbjct: 121 PMIAPTLKGTPSSSAPLALVALAPHS----VQKSSAFPPNLLTSPPSVAVAESGSVITLS 176
Query: 429 ANLMSSTIKTPQGHLMS-ALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSL------IR 481
A + S KT + S +P PSPP +P TP S+ +
Sbjct: 177 APIAPSEPKTNLNKVPSEVVPNPKGTPSPP-----CIVSTVPYHCVTPMASIQSGVASLP 231
Query: 482 SLTPTSNL 489
TPT+ L
Sbjct: 232 QTTPTTTL 239
Score = 42.0 bits (97), Expect = 0.002
Identities = 75/340 (22%), Positives = 119/340 (35%), Gaps = 52/340 (15%)
Query: 265 PSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQG----SATK 320
P KQ+ + SS K P+ P LP ++ A +S++ +AT
Sbjct: 1478 PPAPKQVATSSSP----KKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATL 1533
Query: 321 QQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTL 380
TP+ P L PP VPSP P P P +P S S S ++ ST
Sbjct: 1534 LSKKTPATLA-PKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEAS--SPPAVTPSTY 1590
Query: 381 RGSPNALLSSMTSSSNAALGPAMPY-APEKLPSPALTQQPQFGPQSSILANLMSSTIKTP 439
+G+P S + PA+ +P++ P+P P +P
Sbjct: 1591 KGAP--------SPKELLIPPAVTSPSPKEAPTPPAVTPP------------------SP 1624
Query: 440 QGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQ 499
+ + P P SPP P L S T C + ++ S L ++
Sbjct: 1625 EKGPATPAPKGTP-TSPPVTPSSLKDSPTSPASVT--CKMGATVPQASKGLPAKKGPTAL 1681
Query: 500 QQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEP-------FTFGNTKPLSHFVSEP 552
++ V+ P + S+ ++ ++G + AT P G+ PLS P
Sbjct: 1682 KE---VLVAP-APESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAP 1737
Query: 553 GPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATA 592
T++ H + P S A+ TA A
Sbjct: 1738 LLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAA 1777
Score = 40.4 bits (93), Expect = 0.006
Identities = 68/314 (21%), Positives = 97/314 (30%), Gaps = 27/314 (8%)
Query: 273 SPSSSMAQSKSQVQAMLPVALPP-------LPVPQWHHAHQLKALAASKQGSATKQQGPT 325
SP +A + P A PP P P+ + K G AT
Sbjct: 1112 SPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGA 1171
Query: 326 PSWSGLPPP----GLSPPY------RPVPSPHPPPLPLPPPPPPFSPQSLMVSCMS-SNT 374
P+ PP GL+ P P +P P L P P +P + + S
Sbjct: 1172 PTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG 1231
Query: 375 LSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQF-----GPQSSILA 429
L+ + +G+P ++ S GPA P P+ P+P P P
Sbjct: 1232 LATPSPKGAPTTPAATPPSPKG---GPATP-PPKGAPTPPAATPPSLKGGLATPPHKGAP 1287
Query: 430 NLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNL 489
N T +P+G ++ P P P P SPG P P + +P
Sbjct: 1288 NPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTP 1347
Query: 490 LSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFV 549
+ K + + T S M SP P S V
Sbjct: 1348 TLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAV 1407
Query: 550 SEPGPQKMPSMPTT 563
P+K P+ P T
Sbjct: 1408 IPLSPKKAPATPVT 1421
Score = 40.4 bits (93), Expect = 0.006
Identities = 66/282 (23%), Positives = 98/282 (34%), Gaps = 41/282 (14%)
Query: 314 KQGSATK--QQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMS 371
K G AT + PTP + PP P P P P P + PP P
Sbjct: 1298 KGGPATSPPKGAPTPP-AATPPSPKGSPGTPPPKGAPTPPAVTPPSP------------- 1343
Query: 372 SNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANL 431
+G+P L + T SS GP P + E PA T + GP + +
Sbjct: 1344 ---------KGTPT--LPATTPSSKG--GPTTPSSKEGPTPPAATPSHKGGPAMTPPSPK 1390
Query: 432 MSSTIKTPQGHLMS--ALPAS-NPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSN 488
I +P+G S +P S P+ P E ++P + TP SL
Sbjct: 1391 RGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPS--KGDLTPPAVTPVSLKKAPA 1448
Query: 489 LLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHF 548
+ + + + ++ S K +Q SSSP P
Sbjct: 1449 TSAPKGGPATPSSKGDPTLPAVTPPSPKE-PPAPKQVATSSSPKKAPATPAPMGAPTLPA 1507
Query: 549 VSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTA 590
V P+++P+ P++ R P PT T S T ++ A
Sbjct: 1508 VIPSSPKEVPATPSSRRDPI------APTATLLSKKTPATLA 1543
Score = 36.6 bits (83), Expect = 0.091
Identities = 87/411 (21%), Positives = 134/411 (32%), Gaps = 72/411 (17%)
Query: 207 PLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPS 266
PLV P +++ TTP + + ++ ++C + P SS IS P+
Sbjct: 426 PLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATC-------VSPPMSSGPISNIEPT 478
Query: 267 TSKQIVSPSSSMAQSKSQVQAMLPVAL-PPLPVPQWHHAHQLKALAASKQGSATKQQGPT 325
+ +V + + +QV L + + PPLP P+ LK L +S Q+
Sbjct: 479 SPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPE-----DLKNLPSSVLVKFPTQKDLQ 533
Query: 326 PSWSGLPPPGLSPPYRPVPSPHPPP-LPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSP 384
+ L SP + + P LPL P SP
Sbjct: 534 TVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPS--------------------- 572
Query: 385 NALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLM 444
S +SS L P A + L P +P S + N +S IKT
Sbjct: 573 ---FQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDS---- 625
Query: 445 SALPASNPGPSPPYRPEKLSSP---GLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQ 501
+ P + P L +P P +S P + TS + +
Sbjct: 626 ----YAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTV 681
Query: 502 QANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQK---MP 558
P+ + TL ++ +S P PL+ V P K P
Sbjct: 682 SLAPKNHPVKEGTLTTLPLV----PTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSP 737
Query: 559 SMP----------------TTSRQPSLLHYLQQPTPTQASSATASSTATAT 593
S+P T++ P + PT +SATASS T T
Sbjct: 738 SLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLT 788
Score = 35.4 bits (80), Expect = 0.20
Identities = 118/535 (22%), Positives = 173/535 (32%), Gaps = 113/535 (21%)
Query: 97 PGAHPST-----ACAELQVPPLTINPSP--AAMGVAGQSLLLENNPMNGNIMGSPFVVPQ 149
P PST + EL +PP +PSP A A E P G+P P
Sbjct: 1583 PAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPV 1642
Query: 150 TTEVGLKGPTVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLV 209
T PT P V Q + L + P L E ++ PE +
Sbjct: 1643 TPSSLKDSPTSPASVTCKMGATVPQASKGLPAK------KGPTALK-EVLVAPAPESTPI 1695
Query: 210 LDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSK 269
+ P T K S A+S S G S +S P+
Sbjct: 1696 ITAPTRKGPQTKKSS---------ATSPPICPDPSAKNG-------SKGPLSTVAPAPLL 1739
Query: 270 QIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWS 329
+ SS A+ K + PL P+ + L A A K + + S S
Sbjct: 1740 PVQKDSSKTAKGKDASHS----PKGPLAPPESKASTPLTAAAFEK----VLPKPESASVS 1791
Query: 330 GLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLS 389
P P +S P P P+P PP F P SP +L
Sbjct: 1792 AAPSPPVSLPLA------PSPVPTLPPKQQFLP-------------------SSPGLVLE 1826
Query: 390 SMTSSSNAALGPAMPYAP--EKLPSPALTQQPQFG--PQSSILANL---MSSTIKTPQGH 442
S P+ P AP E P + +P G P S+L N+ S+ I P
Sbjct: 1827 S----------PSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPS 1876
Query: 443 LMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQ 502
+ +N G ++ S P L +Q T + QQ Q
Sbjct: 1877 AKQPVTKNNKGSGTESDSDE-SVPELEEQDSTQATT----------------QQAQLAAA 1919
Query: 503 ANVIFKPIS----SNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMP 558
A + +P+S S S K M + G T T +K + +++P K P
Sbjct: 1920 AEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTR-VTIRKSKNILFVITKPDVYKSP 1978
Query: 559 SMPT-----------TSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQ 602
+ T S+Q L + +A S +T T T+Q + ++++
Sbjct: 1979 ASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEE 2033
>gi|38158015 mastermind-like 3 [Homo sapiens]
Length = 1133
Score = 62.0 bits (149), Expect = 2e-09
Identities = 81/329 (24%), Positives = 114/329 (34%), Gaps = 90/329 (27%)
Query: 349 PPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNA----------LLSSMTSSSNAA 398
P P P S +S V S++ GSP A +S+ TS + A
Sbjct: 339 PEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVA 398
Query: 399 LGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMS--ALPASNPGPSP 456
PA P P P+ Q PQ Q+ + + G+L++ A+ + P
Sbjct: 399 STPAAPN-PASSPANCAVQSPQTPNQAHTPGQ---APPRPGNGYLLNPAAVTVAGSASGP 454
Query: 457 PYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQA------------- 503
P SP + Q L QQQQQQQQQQQ
Sbjct: 455 VAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQHSNQTSNW 514
Query: 504 --------------------------------NVIFKPISSNSSKT----------LSMI 521
N I P+++N KT ++MI
Sbjct: 515 SPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMI 574
Query: 522 MQQGMASSSPGATEP---FTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTP 578
QQ + + T+GNTKPL+HF ++ + P + ++ P L+ Y+QQ
Sbjct: 575 NQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNP-LMPYIQQQQQ 633
Query: 579 TQASSATASSTATATLQLQQQQQQQQQQP 607
Q QQQQQQQQQQP
Sbjct: 634 QQQ---------------QQQQQQQQQQP 647
Score = 50.4 bits (119), Expect = 6e-06
Identities = 130/572 (22%), Positives = 192/572 (33%), Gaps = 96/572 (16%)
Query: 173 DQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKP-SVQMSHLE 231
DQE QEL++EL + E D++ + EE P+ + T P S + + ++
Sbjct: 306 DQEWQELIDELAN----TVPEDDIQDLFNEDFEEK---KEPEFSQPATETPLSQESASVK 358
Query: 232 SLASSKEFAS---SCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQ-- 286
S S FA Q S P S+ + S+PS + +P+ + + + VQ
Sbjct: 359 SDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSP 418
Query: 287 -----AMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPP-- 339
A P PP P + + L A + GSA+ GP +P +SP
Sbjct: 419 QTPNQAHTPGQAPPRP----GNGYLLNPAAVTVAGSAS---GPV----AVPSSDMSPAEQ 467
Query: 340 YRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTL----SGSTLRGSPNALLSSMTSSS 395
+ + + L Q S T SP L +S
Sbjct: 468 LKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSP---LGPPSSPY 524
Query: 396 NAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKT--PQGHL-MSALPASNP 452
AA P +P P Q P P ++ NL +T+ PQ H+ M +N
Sbjct: 525 GAAFTAEKPNSPMMYPQAFNNQNPIVPPMAN---NLQKTTMNNYLPQNHMNMINQQPNNL 581
Query: 453 GPSPPYRPEKLSSPG--LPQQSFTPQCSLIRSLTPTSN--------LLSQQQQQQQQQQQ 502
G + + + + G P F S R P +N + QQQQQQQQQQQ
Sbjct: 582 GTNSLNKQHNILTYGNTKPLTHFNADLSQ-RMTPPVANPNKNPLMPYIQQQQQQQQQQQQ 640
Query: 503 ANVIFKPIS----------SNSSKTLSMIMQQG--------------------------- 525
+P S K L ++ Q+G
Sbjct: 641 QQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTT 700
Query: 526 --MASSSPGATEPFTFGNTKPLSHFV-SEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQAS 582
M SS P + G + F+ S+P M M R + QQ Q
Sbjct: 701 GPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQ 760
Query: 583 SATASSTATATLQLQQQQQQQQQ-QPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQGC 641
A QLQQ +Q QP + + +QQ+ Q Q A S AL
Sbjct: 761 QQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRT 820
Query: 642 CHLFAWTSAASSVKPQHQHGNSFTSRQDPQPG 673
L A + + P G T+ + G
Sbjct: 821 SRLMAQNAGMMGIGPSQNPGTMATAAAQSEMG 852
>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
Length = 1682
Score = 61.2 bits (147), Expect = 3e-09
Identities = 51/189 (26%), Positives = 69/189 (36%), Gaps = 9/189 (4%)
Query: 272 VSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGL 331
V+P + + + +Q+ P P A+A + + T T
Sbjct: 719 VAPQPPLKEPFASLQSPFPTDTAPTTTAP--------AVAVTTTTTTTTTTTATQEEEKK 770
Query: 332 PPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSM 391
PPP L PP P+ PP P PPPPPP SP SL+ S S RG+ A+ +
Sbjct: 771 PPPALPPP-PPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRP 829
Query: 392 TSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASN 451
P P LP + Q PQ S ++ ST P A
Sbjct: 830 GPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPV 889
Query: 452 PGPSPPYRP 460
PGP P +P
Sbjct: 890 PGPMTPTQP 898
Score = 46.2 bits (108), Expect = 1e-04
Identities = 48/172 (27%), Positives = 62/172 (36%), Gaps = 32/172 (18%)
Query: 320 KQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPF--SPQSLMVSCMSSNTLSG 377
+++G +GLPP GL P P+P P PPP P PPP P SP + +TL G
Sbjct: 229 RRRGCNSEQTGLPP-GLPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHG 287
Query: 378 STLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIK 437
+L PY P+PA T
Sbjct: 288 DAWGPERKGSAPPERQEQRHSLPHPYPY-----PAPAYTAH------------------- 323
Query: 438 TPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNL 489
P GH + +PA+ PGP P RP S G + P L S S +
Sbjct: 324 -PPGHRL--VPAAPPGPGP--RPPGAESHGCLPATRPPGSDLRESRVQRSRM 370
Score = 43.5 bits (101), Expect = 7e-04
Identities = 41/144 (28%), Positives = 49/144 (34%), Gaps = 22/144 (15%)
Query: 290 PVALPPLPVPQWHHAHQLKALAASKQGSATKQ--------QGPTPSWSGLPPPGLSPPYR 341
P LPP P P L LA S TK P G PP
Sbjct: 248 PPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRH 307
Query: 342 PVPSPHPPPLPL--------------PPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNAL 387
+P P+P P P PP P P P + C+ + GS LR S
Sbjct: 308 SLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDLRESRVQR 367
Query: 388 LSSMTSSSNAALGPAMPYAPEKLP 411
+S S AA +PYAP + P
Sbjct: 368 SRMDSSVSPAATTACVPYAPSRPP 391
Score = 43.5 bits (101), Expect = 7e-04
Identities = 121/559 (21%), Positives = 180/559 (32%), Gaps = 93/559 (16%)
Query: 254 PSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAAS 313
P+++T PS + ++S + S S + V P +P H +Q AL S
Sbjct: 376 PAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNP-GIPGADH-YQTPALEVS 433
Query: 314 KQGSATKQQGPTPSWSGLP-------PPGLSPPYRPVPSPHPPPLP--LPPPPPPFSPQS 364
G + GP+ S P P LS P P SP PPP P L PPPPP
Sbjct: 434 HHG----RLGPSAHSSRKPFLGAPAATPHLSLPPGP-SSPPPPPCPRLLRPPPPP----- 483
Query: 365 LMVSCMSSNTLSGSTLRGS--PNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFG 422
L G R + +L + + GP P AP LP ++ G
Sbjct: 484 --------AWLKGPACRAAREDGEILEELFFGTE---GPPRP-APPPLPH----REGFLG 527
Query: 423 PQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRS 482
P +S ++ T H P S SSP P SF P L RS
Sbjct: 528 PPAS------RFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGP-VSFPPPPYLARS 580
Query: 483 LTPTSNLLSQQQQQQQQQQQANVIFKP------ISSNSSKTLSMIMQQGMASSSPGATEP 536
+ P S Q Q + P N+S + S P E
Sbjct: 581 IDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEV 640
Query: 537 FTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSAT-----ASSTAT 591
PLS +P P + +P +R P L + P Q A
Sbjct: 641 GPGPPPGPLSK-APQPVPPGVGELP--ARGPRLFDFPPTPLEDQFEEPAEFKILPDGLAN 697
Query: 592 ATLQLQQQQQQQQQQPDHSSFLL-QQMMQQP-QRFQRSVASDSMPALPRQGCCHLFAWTS 649
L + +++++Q H + + Q +++P Q +D+ P T+
Sbjct: 698 IMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTT 757
Query: 650 AASSVKPQHQHGN------------SFTSRQDPQPGDVSP----------SNITHVDKAC 687
++ Q + F PQP P +++ K C
Sbjct: 758 TTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYC 817
Query: 688 KLGEARH--------PQVSLGRQPPS-CQALGSESFLPGSSFAHELARVTSSYSTSEAAP 738
G P PPS AL S P + + + + +SS ++ P
Sbjct: 818 YRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGP 877
Query: 739 WGSWDPKAWRQVPAPLLPS 757
W VP P+ P+
Sbjct: 878 WARERRAGEEPVPGPMTPT 896
Score = 31.6 bits (70), Expect = 2.9
Identities = 43/154 (27%), Positives = 58/154 (37%), Gaps = 26/154 (16%)
Query: 204 PEEPLV-LDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISY 262
P PL P P P S L+SLAS E C + TG ++ S+ G
Sbjct: 777 PPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAV---STRPG--- 830
Query: 263 SIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQ 322
+P+T PS + ALPP + ++S Q S +
Sbjct: 831 PLPTTQYSPGPPSGA-------------TALPPTSAAPSAQGSPQPSASSSSQFSTSG-- 875
Query: 323 GPTPSWSGLPPPGLSPPYRPV-PSPHPPPLPLPP 355
GP W+ G P P+ P+ PPPL LPP
Sbjct: 876 GP---WARERRAGEEPVPGPMTPTQPPPPLSLPP 906
>gi|150417989 cyclin K isoform 1 [Homo sapiens]
Length = 580
Score = 61.2 bits (147), Expect = 3e-09
Identities = 76/292 (26%), Positives = 104/292 (35%), Gaps = 37/292 (12%)
Query: 207 PLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPS 266
P L P + T P VQ S + + Q Q P+ PS
Sbjct: 270 PHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQ-PAQQPKKPSPQPS 328
Query: 267 TSKQIVSPSSSMAQSKSQVQAMLPVALPPL-----PVPQWHHAHQLKALAASKQGSATKQ 321
+ +Q+ + +++ P +P + P+P H K A+ G A +
Sbjct: 329 SPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEA-EP 387
Query: 322 QGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLR 381
GP + + LP + PP P P PPPLP PPPPP S S M+ + + S +
Sbjct: 388 PGPVDA-TDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPS------SYMTGMSTTSSYMS 440
Query: 382 GSPNALLSSMTSS---SNAALGPA------MPYAPEKLPSPALTQQPQFGPQSSILANLM 432
G L SM + S AL PA +PY P P P P A+
Sbjct: 441 GEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYP-----PNPPPPPVPPPPASFP 495
Query: 433 SSTIKTPQGHLMSALPASNPG--PSPPYRPEKLSSP-------GLPQQSFTP 475
I P P NP P PP P + P GLP S+ P
Sbjct: 496 PPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPP 547
Score = 41.2 bits (95), Expect = 0.004
Identities = 51/204 (25%), Positives = 72/204 (35%), Gaps = 31/204 (15%)
Query: 179 LLEELTKIQDPSP-NELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSK 237
L L + + P P + DL K+ P P + P L P P S++ ++++
Sbjct: 378 LAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPP-LPHRPPPPPPSSYMTGMSTTS 436
Query: 238 EFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLP 297
+ S SLQ + G SY + P+ + P PP P
Sbjct: 437 SYMSGEGY---QSLQSMMKTEGPSYGA-------LPPAYGPPAHLPYHPHVYPPNPPPPP 486
Query: 298 VPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPP---LP-- 352
VP + A+ G P++ PPP PP VP PHPPP LP
Sbjct: 487 VPPPPASFPPPAIPPPTPGYPPPPPTYNPNFP--PPPPRLPPTHAVP-PHPPPGLGLPPA 543
Query: 353 -----------LPPPPPPFSPQSL 365
PP PPP P +
Sbjct: 544 SYPPPAVPPGGQPPVPPPIPPPGM 567
Score = 38.1 bits (87), Expect = 0.031
Identities = 60/214 (28%), Positives = 77/214 (35%), Gaps = 41/214 (19%)
Query: 553 GPQKMPS-MPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSS 611
G Q+MP P +QP L Q Q S + SS + Q QQ QQQQP
Sbjct: 261 GKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQP---- 316
Query: 612 FLLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQ 671
QQP++ P+ PRQ A V P+ ++ +P
Sbjct: 317 ------AQQPKK------PSPQPSSPRQ--------VKRAVVVSPKEEN-----KAAEPP 351
Query: 672 PGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSFAHELARVTSSY 731
P + TH L A P R+PP ALG E+ PG A +L +V
Sbjct: 352 PPKIPKIETTHP----PLPPAHPPP---DRKPPLAAALG-EAEPPGPVDATDLPKVQIP- 402
Query: 732 STSEAAPWGSWDPKAWRQVPAPLLPSCDATARGT 765
+ AP P R P P PS T T
Sbjct: 403 PPAHPAPVHQPPPLPHRPPPPP--PSSYMTGMST 434
>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
Length = 3230
Score = 60.8 bits (146), Expect = 5e-09
Identities = 126/556 (22%), Positives = 192/556 (34%), Gaps = 111/556 (19%)
Query: 94 AMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLLENNPMNGNIM-----GSPFVVP 148
A PGA P T + L VP P+ + M + S L +P++ + P VP
Sbjct: 1387 ASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLA--SPVSSTVSVPLSSSLPISVP 1444
Query: 149 QTTEVGLKGP-TVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEP 207
T P T+P + + L + L + +P L +
Sbjct: 1445 TTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASA 1504
Query: 208 LVLD---HPQATLSTTPKPSVQM----SHLESLASSKEFASSCSQVTGMSLQIPSSSTGI 260
L L P + S TP + + SH+ L S+ A +CS V +P+S+ +
Sbjct: 1505 LTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNST--VAPACSPVL-----VPASA--L 1555
Query: 261 SYSIPSTSKQIVSPSSSMAQSKSQVQAML----PVALPPLPVPQWHHAHQLKALA--ASK 314
+ PS + +S +A + S QA+ P+A P + A L L A
Sbjct: 1556 ASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPS 1615
Query: 315 QGSA---TKQQGPTPSWSGLPPPGLS-PPYRPVPSPHPP----------PLPLPPP-PPP 359
G+A Q P P + PG S PVP+P P P P+P P P P
Sbjct: 1616 PGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSP 1675
Query: 360 FSPQSLMVSCMSSNTLSGSTLR-------GSPNALLSSMTSSSNAA-------------- 398
S Q+L ++ + TL GS+ G+P + T S A
Sbjct: 1676 ASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLA 1735
Query: 399 ------------LGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSA 446
L PA P AP PA P SS + L ++++T ++
Sbjct: 1736 PGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQT-----LTL 1790
Query: 447 LPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVI 506
PA P + P + +L P S Q QA+ +
Sbjct: 1791 SPA-------------------PVPTLGPAAAQTLALAPAST--------QSPASQASSL 1823
Query: 507 FKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQ 566
S + ++M+ + ++ P T G P S S GP+ P R
Sbjct: 1824 VVSASGAAPLPVTMVSRLPVSKDEPD-TLTLRSGPPSPPSTATSFGGPRPRRQPPPPPRS 1882
Query: 567 PSLLHYLQQPTPTQAS 582
P L L++ Q S
Sbjct: 1883 PFYLDSLEEKRKRQRS 1898
Score = 58.2 bits (139), Expect = 3e-08
Identities = 124/537 (23%), Positives = 199/537 (37%), Gaps = 74/537 (13%)
Query: 77 GGYPNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLLENNPM 136
GG + I +P + A+ P P+ +P T + +PA G+ SL L N +
Sbjct: 1245 GGQHHLISQPAHVALIQAVAPTPGPTPVSV---LPSSTPSTTPAPTGL---SLPLAANQV 1298
Query: 137 NGNIMGSPFVVPQTTEVGLKGPTVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELDL 196
++ + VV + P VP + + L + +P P
Sbjct: 1299 PPTMVNNTGVVKIVVRQAPRDGLTP-------VPPLAPAPRPPSSGLPAVLNPRPTLTP- 1350
Query: 197 EKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSS 256
G P L T +P +++ H S S + L +PSS
Sbjct: 1351 ----GRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSS 1406
Query: 257 STGISYS---IPSTSKQIVSPSSSMAQSKSQVQAMLPVALPP-LPVPQWHHAHQLKALAA 312
G + S IP++S + SP SS + + LP+++P LP P A ++A
Sbjct: 1407 LPGPASSPMPIPNSSP-LASPVSSTVSVP--LSSSLPISVPTTLPAPA--SAPLTIPISA 1461
Query: 313 SKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSS 372
SA+ GP S ++PP PV P P L P S +L + ++
Sbjct: 1462 PLTVSAS---GPALLTS------VTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATA 1512
Query: 373 NTLSGSTLRGSPNAL--LSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGP-----QS 425
+LS S G P L SS N+ + PA +P +P+ AL P Q+
Sbjct: 1513 PSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPAC--SPVLVPASALASPFPSAPNPAPAQA 1570
Query: 426 SILANLMSST---------IKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQ 476
S+LA S++ + PQ +++ PA P P P ++P L S TP
Sbjct: 1571 SLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVL-ASSQTPV 1629
Query: 477 CSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEP 536
+ S TP ++L S A+ + P + + ++ + S P
Sbjct: 1630 PVMAPSSTPGTSLAS-----------ASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPAST 1678
Query: 537 FTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATAT 593
T L+ + P + S+ T + Q P PTQ S T +S+ T
Sbjct: 1679 QTLALAPALAPTLGGSSPSQTLSLGTGNP--------QGPFPTQTLSLTPASSLVPT 1727
Score = 52.4 bits (124), Expect = 2e-06
Identities = 107/466 (22%), Positives = 163/466 (34%), Gaps = 64/466 (13%)
Query: 286 QAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSP-PYRPVP 344
+ +L VA P P P+ +K KQ+G T P L P P RP P
Sbjct: 972 RVLLEVATAPDPPPR---PKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPP 1028
Query: 345 SPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMP 404
P P P P P P SLMVS + G P L+ + L P P
Sbjct: 1029 GPELSAQPTPGPVPQVLPASLMVSASPA---------GPP--LIPASRPPGPVLLPPLQP 1077
Query: 405 YA---PEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPE 461
+ P+ LPSP P + L+ + T P + PA PG S +P
Sbjct: 1078 NSGSLPQVLPSPLGVLSGTSRPPTPTLS--LKPTPPAP----VRLSPAPPPGSSSLLKP- 1130
Query: 462 KLSSPGLPQQSFTPQCSLIRSLT---------------PTSNLLSQQQQQQQQQ------ 500
L+ P P +F P + S T P +LS Q +
Sbjct: 1131 -LTVP--PGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSI 1187
Query: 501 -QQANVIFKPI-SSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLS----HFVSEPGP 554
Q A++ +P+ ++ SK L+ +Q + + G +PL H VS G
Sbjct: 1188 GQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQ 1247
Query: 555 QKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQPD--HSSF 612
+ S P + PTP ++ ST A L Q P +++
Sbjct: 1248 HHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTG 1307
Query: 613 LLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQP 672
+++ +++Q R + PA PR L A + ++ P + + + P P
Sbjct: 1308 VVKIVVRQAPRDGLTPVPPLAPA-PRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMP 1366
Query: 673 GDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGS 718
T V KL + P+VS + + S +P S
Sbjct: 1367 ------TPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSS 1406
Score = 40.4 bits (93), Expect = 0.006
Identities = 70/308 (22%), Positives = 107/308 (34%), Gaps = 38/308 (12%)
Query: 304 AHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRP--VPSPHPPPLP--------- 352
AHQ ++ + S +++ P P+ P P +P P VP P P+P
Sbjct: 2417 AHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITI 2476
Query: 353 -----LPPPPPPFS-PQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYA 406
LP PPPP P +C + P A +T SS LGP
Sbjct: 2477 LPVHILPSPPPPSQIPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPI 2536
Query: 407 PEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKL--S 464
+ + L +P+ + LA+ S + + S+L P P E L S
Sbjct: 2537 SASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVS 2596
Query: 465 SPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQ 524
L S TP SLT + + Q+Q+ + L +
Sbjct: 2597 EKNL---SLTPSAP---SLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESN 2650
Query: 525 GM-----ASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPT 579
G+ A+S EP T E K P+ ++ +P L + P+
Sbjct: 2651 GLELPPSAASDEPLQEPLEADRTS------EELTEAKTPT--SSPEKPQELVTAEVAAPS 2702
Query: 580 QASSATAS 587
+SSAT+S
Sbjct: 2703 TSSSATSS 2710
Score = 35.8 bits (81), Expect = 0.16
Identities = 37/143 (25%), Positives = 57/143 (39%), Gaps = 21/143 (14%)
Query: 272 VSPSSSMAQSKSQVQAMLPVALPPLPV---PQWHHAHQLKALAASKQGSAT-KQQGPTPS 327
V P+S M + ++P + PP PV P ++ L + S G + + PTP+
Sbjct: 1044 VLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPT 1103
Query: 328 WSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNAL 387
S P P P P+ L P PPP S L + G T +
Sbjct: 1104 LSLKPTP-------------PAPVRLSPAPPPGSSSLLKPLTVP----PGYTFPPAAATT 1146
Query: 388 LSSMTSSSNAALGPAMPYAPEKL 410
S+ T+++ PA AP++L
Sbjct: 1147 TSTTTATATTTAVPAPTPAPQRL 1169
Score = 32.3 bits (72), Expect = 1.7
Identities = 69/309 (22%), Positives = 107/309 (34%), Gaps = 47/309 (15%)
Query: 171 AVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHL 230
A D+ LQE LE D + EL K + PE+P L + +T +
Sbjct: 2659 ASDEPLQEPLEA-----DRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEG 2713
Query: 231 ESLASSKEFASSCS-QVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAML 289
S A +S ++ G P G P +++ ++ + K V+
Sbjct: 2714 PSPARPPRRRTSADVEIRGQGTGRPGQPPG-----PKVLRKLPGRLVTVVEEKELVR--- 2765
Query: 290 PVALPPLPVPQWHHAHQLKALAASKQGSATKQQGP-TPSWSGLPPPGLSPPYR-PVPSPH 347
Q A + G + P +PS + P SPP P +
Sbjct: 2766 ------------RRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAP 2813
Query: 348 PPPLPLPPPPPPFSPQSLMVSCM---SSNTLSGSTLRGSPNALLSSM-----TSSSNAAL 399
LP PP P + + + + S G+ L +P A+ + S A
Sbjct: 2814 SSSLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADA 2873
Query: 400 GPAMPYAPEK-LPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNP-GPSPP 457
G + AP L P GP++ I+A+ + PQ +P P GP P
Sbjct: 2874 GRGVDEAPSSTLKGKTNGADPVPGPETLIVAD----PVLEPQ-----LIPGPQPLGPQPV 2924
Query: 458 YRPEKLSSP 466
+RP L SP
Sbjct: 2925 HRPNPLLSP 2933
Score = 32.3 bits (72), Expect = 1.7
Identities = 39/149 (26%), Positives = 57/149 (38%), Gaps = 34/149 (22%)
Query: 320 KQQGPTPSWSGLPPPGL-------SPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSS 372
+++G P LP PG + R P PHP PL P PP P + + + +++
Sbjct: 2937 RRRGRPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPL-TPLPPLLVCPTATVANTVTT 2995
Query: 373 NTLSGS---TLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQS-SIL 428
T+S S RG P P+ PSP +Q P S S+L
Sbjct: 2996 VTISTSPPKRKRGRP----------------------PKNPPSPRPSQLPVLDRDSTSVL 3033
Query: 429 ANLMSSTIKTPQGHLMSALPASNPGPSPP 457
+ + PQG S +S+ S P
Sbjct: 3034 ESCGLGRRRQPQGQGESEGSSSDEDGSRP 3062
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 59.7 bits (143), Expect = 1e-08
Identities = 107/489 (21%), Positives = 174/489 (35%), Gaps = 81/489 (16%)
Query: 204 PEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYS 263
P +PL P A + + KPS + ++LA + +Q G + + P+ G
Sbjct: 362 PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPA-KPPTQQVGTPKP 420
Query: 264 IPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQG 323
+ + + SP+ + +K+ VQ P +P A A ++ +Q G
Sbjct: 421 L-AQQPGLQSPAKAPGPTKTPVQQPGPGKIP--------------AQQAGPGKTSAQQTG 465
Query: 324 PTPSWSGLPPPGLSPPYRPVPSPHPPPLP-------------LPPP-------PPPFSPQ 363
PT S LP P PP +P P+ PP P PPP P P P
Sbjct: 466 PTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPG 525
Query: 364 SLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGP 423
S + S + SP + ++ + G P P + SP+ Q P G
Sbjct: 526 STKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTV-SPSAKQPPSQGL 584
Query: 424 QSSI--LANLMSSTIKTPQ----------GHLMSALPASNPGPSPPYRPEKLS------- 464
+I L N + P+ + +L NP P E L
Sbjct: 585 PKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKR 644
Query: 465 --SPGLPQQSFTPQCSL-IRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNS--SKTLS 519
L +PQ L +T TS + Q QQ + + K S + K
Sbjct: 645 ALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPP 704
Query: 520 MIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTS----------RQPSL 569
+++Q SP A P + +S+P P K PS+P+ +QP +
Sbjct: 705 PLVKQPTLHGSPSAK-----AKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKM 759
Query: 570 LHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVA 629
+ +PT SS++A++ Q Q +++ P + + P ++
Sbjct: 760 V----KPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSP 815
Query: 630 SDSMPALPR 638
DS A+PR
Sbjct: 816 FDS-KAIPR 823
Score = 48.5 bits (114), Expect = 2e-05
Identities = 77/295 (26%), Positives = 105/295 (35%), Gaps = 62/295 (21%)
Query: 312 ASKQGSATKQQGPT-----PSWSGLP----PPGLSPPYRPVPSPHPPPLPLPPPPPPFSP 362
A + G Q GP PS P P + PP +P + PP PL P PP
Sbjct: 316 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPP--- 372
Query: 363 QSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFG 422
+ + S+ + P AL A P + P + P PA Q G
Sbjct: 373 ------AQQTGSEKPSSEQPGPKAL----------AQPPGVGKTPAQQPGPAKPPTQQVG 416
Query: 423 PQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPG-LPQQSFTPQCSLIR 481
+ Q L S PA PGP+ P + PG +P Q P + +
Sbjct: 417 TPKPL----------AQQPGLQS--PAKAPGPTK--TPVQQPGPGKIPAQQAGPGKTSAQ 462
Query: 482 SLTPT---SNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFT 538
PT S L + QQ A P S+K S Q S+ P +P
Sbjct: 463 QTGPTKPPSQLPGPAKPPPQQPGPAKP--PPQQPGSAKPPS----QQPGSTKPPPQQP-- 514
Query: 539 FGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATAT 593
G KP +PG K PS S +PS QQP+P + S+ ++ + T
Sbjct: 515 -GPAKPSP---QQPGSTKPPSQQPGSAKPS----AQQPSPAKPSAQQSTKPVSQT 561
Score = 47.8 bits (112), Expect = 4e-05
Identities = 73/303 (24%), Positives = 120/303 (39%), Gaps = 43/303 (14%)
Query: 329 SGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVS----CMSSNTLSGSTLRGSP 384
S PPP PP P P P PPP P PP PPP SP+ ++ ++S + + L +
Sbjct: 2402 SAQPPPPPPPP--PPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAV 2459
Query: 385 NALLSSMTSSSN--------AALGPAMPYAPEKLPSPAL------TQQPQFGPQSSILAN 430
L ++ SN P +P P +PS + +P P+ ++
Sbjct: 2460 TTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPK-PVIPQ 2518
Query: 431 LMSSTIK------TPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQS-FTPQCSLIRSL 483
L ++T K P G +++ N S Y+ +SP P + +P+ S +SL
Sbjct: 2519 LPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFS--KSL 2576
Query: 484 TPT---SNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSM-----IMQQGMASSSPGATE 535
T T L S+ + P+ S S +S+ ++ A P ++E
Sbjct: 2577 TETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSE 2636
Query: 536 PFTFGNTKPLSHFVSEP--GPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATAT 593
TF + L F + P P + PT+ Q L T A+ +TA S ++
Sbjct: 2637 Q-TFYISGALQTFSATPVTAPSSFQAAPTSVTQ--FLTTEVSKTEVSATRSTAPSVGLSS 2693
Query: 594 LQL 596
+ +
Sbjct: 2694 ISI 2696
Score = 39.3 bits (90), Expect = 0.014
Identities = 65/275 (23%), Positives = 94/275 (34%), Gaps = 49/275 (17%)
Query: 318 ATKQQGPTPSWSGLPP---PGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNT 374
A++ +PS S LP P + + PPP P PPPPPP P
Sbjct: 2373 ASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPP----------- 2421
Query: 375 LSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSS 434
P L TS L P + SP T P F +++ +
Sbjct: 2422 --------PPPPPLPPPTSPKPTIL----PKKKLTVASPVTTATPLFDAVTTLETTAVLR 2469
Query: 435 TIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQ 494
+ P + + P P P P P L P+ S P + P + Q
Sbjct: 2470 SNGLPVTRICTTAPPPVP-PKPSSIPSGLVFTHRPEPSKPP-------IAPKPVI---PQ 2518
Query: 495 QQQQQQQQANVIFKP--ISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEP 552
Q+ ++ KP +S SS TL+++ SP T PLS ++
Sbjct: 2519 LPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSP----------TSPLSPHSNKS 2568
Query: 553 GPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATAS 587
P+ S+ T +L PT + AS A S
Sbjct: 2569 SPRFSKSLTETYVVITLPSEPGTPTDSSASQAITS 2603
Score = 37.7 bits (86), Expect = 0.041
Identities = 81/369 (21%), Positives = 116/369 (31%), Gaps = 66/369 (17%)
Query: 293 LPPLPVPQWHHAHQLKALAASK------QGSATKQQGPTPSWSGLPPPGLSPPYRPVPSP 346
+P P P+ A A SK Q S K P S P P PP P+
Sbjct: 653 VPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTL 712
Query: 347 HPPPLPLPPPPP-------PFSPQSLMVSCMSSNTLSGSTLRGSPNAL--LSSMTSSSNA 397
H P PP P P+ V P + + + SSS+A
Sbjct: 713 HGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSA 772
Query: 398 ALGPAMP------YAPEKLPSPALTQQPQ----FGPQSSILANLMSSTIKTPQGHLMSAL 447
P +P A EK P T + F P ++ S I P +
Sbjct: 773 TTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPAS---DSK 829
Query: 448 PASNPGPSPPYRPEKLSSP---------GLPQQSFTPQCSLIRSLTPT--------SNLL 490
S+PGPS + +K P + S P + +PT +
Sbjct: 830 IISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTV 889
Query: 491 SQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNT-------- 542
QQ + Q+Q+ + S N Q + F FG +
Sbjct: 890 PTPQQSPKPQEQS----RRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNL 945
Query: 543 -----KPLSHFVSEPG-PQKM---PSMPTTSRQPSLLHYLQQPTPTQASSATASSTATAT 593
+P H S PG P K PS P TS+ P P P ++ + A A
Sbjct: 946 ISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAA 1005
Query: 594 LQLQQQQQQ 602
+L+ + +Q
Sbjct: 1006 EKLEPKAEQ 1014
Score = 37.4 bits (85), Expect = 0.053
Identities = 74/351 (21%), Positives = 125/351 (35%), Gaps = 53/351 (15%)
Query: 187 QDPS-PNELDLEKILGTKPEEPLVLDHPQ---ATLSTTPKPSVQMSHLESLASSKEFASS 242
++PS P+E D + KP++P ++ ++ S T KP + S ++S A K
Sbjct: 736 KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPL 795
Query: 243 CSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWH 302
+ S P + +S P SK I P+S S++ + H
Sbjct: 796 KTDSAKPSQSFPPTGEKVS---PFDSKAIPRPASD-----SKIIS--------------H 833
Query: 303 HAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSP 362
++ + K++ P + + + P +P P P P PP P P +
Sbjct: 834 PGPSSESKGQKQVDPVQKKEEPKKAQTKMSP-------KPDAKPMPKGSPTPPGPRPTAG 886
Query: 363 QSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFG 422
Q++ T + SP S S N P + P +T + FG
Sbjct: 887 QTV------------PTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGK-LFG 933
Query: 423 PQSSIL--ANLMSSTIKTPQGHLMSALPA-SNPGPSPPYRPEKLSSPGLPQQSFTPQCSL 479
+SI A+ + ST P H S A P+P P P Q+
Sbjct: 934 FGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKS 993
Query: 480 I----RSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGM 526
I + P + L + +Q ++ KP SK+L+ Q+ +
Sbjct: 994 IPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAV 1044
Score = 31.2 bits (69), Expect = 3.8
Identities = 32/138 (23%), Positives = 54/138 (39%), Gaps = 9/138 (6%)
Query: 454 PSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSN 513
PSPP P+ L SP P +P +L + P L Q+ P S
Sbjct: 3614 PSPPKSPKVLYSPISP---LSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPK 3670
Query: 514 SSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYL 573
++K +MQ+ M S P P +++ + + +M ++ Q + L
Sbjct: 3671 TAK----MMQRSM--SDPKPLSPTADESSRAPFQYTEGYTTKGSQTMTSSGAQKKVKRTL 3724
Query: 574 QQPTPTQASSATASSTAT 591
P P + S+ T S+ +T
Sbjct: 3725 PNPPPEEISTGTQSTFST 3742
Score = 30.4 bits (67), Expect = 6.5
Identities = 53/208 (25%), Positives = 70/208 (33%), Gaps = 23/208 (11%)
Query: 549 VSEPGPQKMPSMPTTSRQPSLLHYLQQP-TPTQASSATASSTATATLQLQQQQQQQQQQP 607
+ +P Q+ P P +Q LQQ TP SS + + Q Q P
Sbjct: 206 IIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTP 265
Query: 608 --DHSSFLLQQMMQQPQRFQRSV--ASDSMPALPRQGCCHLFAWTSAASSVKPQHQHGNS 663
DH+ LQ+ +PQ Q + P+LP + T KP Q
Sbjct: 266 QTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPG----KPPAQQPGH 321
Query: 664 FTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSFAHE 723
S+ P PS +T A + G + P G P Q LG A
Sbjct: 322 EKSQPGPAKPPAQPSGLTK-PLAQQPGTVKPPVQPPGTTKPPAQPLGP---------AKP 371
Query: 724 LARVTSSYSTSEAAPWGSWDPKAWRQVP 751
A+ T S S P PKA Q P
Sbjct: 372 PAQQTGSEKPSSEQP----GPKALAQPP 395
Score = 30.4 bits (67), Expect = 6.5
Identities = 40/162 (24%), Positives = 62/162 (38%), Gaps = 30/162 (18%)
Query: 392 TSSSNAALGPAMPYAPEKLPSPAL-TQQPQFGPQSSILANLMSSTIKTPQGHLMSALPAS 450
T + + + P PY + SPAL TQ P Q S + T+ Q
Sbjct: 3872 TQTESQLVPPTSPYTQYQYSSPALPTQAPTSYTQQS---HFEQQTLYHQQ---------- 3918
Query: 451 NPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKP- 509
PY+ + + + SFTPQ + P+ L SQ QQ+ +Q + +P
Sbjct: 3919 ----VSPYQTQP-TFQAVATMSFTPQVQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPK 3973
Query: 510 ISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSE 551
I+SN + + P P + NT +SH S+
Sbjct: 3974 ITSNYE----------VIRNQPLMIAPVSTDNTFAVSHLGSK 4005
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 59.7 bits (143), Expect = 1e-08
Identities = 107/489 (21%), Positives = 174/489 (35%), Gaps = 81/489 (16%)
Query: 204 PEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYS 263
P +PL P A + + KPS + ++LA + +Q G + + P+ G
Sbjct: 362 PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPA-KPPTQQVGTPKP 420
Query: 264 IPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQG 323
+ + + SP+ + +K+ VQ P +P A A ++ +Q G
Sbjct: 421 L-AQQPGLQSPAKAPGPTKTPVQQPGPGKIP--------------AQQAGPGKTSAQQTG 465
Query: 324 PTPSWSGLPPPGLSPPYRPVPSPHPPPLP-------------LPPP-------PPPFSPQ 363
PT S LP P PP +P P+ PP P PPP P P P
Sbjct: 466 PTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPG 525
Query: 364 SLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGP 423
S + S + SP + ++ + G P P + SP+ Q P G
Sbjct: 526 STKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTV-SPSAKQPPSQGL 584
Query: 424 QSSI--LANLMSSTIKTPQ----------GHLMSALPASNPGPSPPYRPEKLS------- 464
+I L N + P+ + +L NP P E L
Sbjct: 585 PKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKR 644
Query: 465 --SPGLPQQSFTPQCSL-IRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNS--SKTLS 519
L +PQ L +T TS + Q QQ + + K S + K
Sbjct: 645 ALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPP 704
Query: 520 MIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTS----------RQPSL 569
+++Q SP A P + +S+P P K PS+P+ +QP +
Sbjct: 705 PLVKQPTLHGSPSAK-----AKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKM 759
Query: 570 LHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVA 629
+ +PT SS++A++ Q Q +++ P + + P ++
Sbjct: 760 V----KPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSP 815
Query: 630 SDSMPALPR 638
DS A+PR
Sbjct: 816 FDS-KAIPR 823
Score = 48.5 bits (114), Expect = 2e-05
Identities = 77/295 (26%), Positives = 105/295 (35%), Gaps = 62/295 (21%)
Query: 312 ASKQGSATKQQGPT-----PSWSGLP----PPGLSPPYRPVPSPHPPPLPLPPPPPPFSP 362
A + G Q GP PS P P + PP +P + PP PL P PP
Sbjct: 316 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPP--- 372
Query: 363 QSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFG 422
+ + S+ + P AL A P + P + P PA Q G
Sbjct: 373 ------AQQTGSEKPSSEQPGPKAL----------AQPPGVGKTPAQQPGPAKPPTQQVG 416
Query: 423 PQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPG-LPQQSFTPQCSLIR 481
+ Q L S PA PGP+ P + PG +P Q P + +
Sbjct: 417 TPKPL----------AQQPGLQS--PAKAPGPTK--TPVQQPGPGKIPAQQAGPGKTSAQ 462
Query: 482 SLTPT---SNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFT 538
PT S L + QQ A P S+K S Q S+ P +P
Sbjct: 463 QTGPTKPPSQLPGPAKPPPQQPGPAKP--PPQQPGSAKPPS----QQPGSTKPPPQQP-- 514
Query: 539 FGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATAT 593
G KP +PG K PS S +PS QQP+P + S+ ++ + T
Sbjct: 515 -GPAKPSP---QQPGSTKPPSQQPGSAKPS----AQQPSPAKPSAQQSTKPVSQT 561
Score = 47.8 bits (112), Expect = 4e-05
Identities = 73/303 (24%), Positives = 120/303 (39%), Gaps = 43/303 (14%)
Query: 329 SGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVS----CMSSNTLSGSTLRGSP 384
S PPP PP P P P PPP P PP PPP SP+ ++ ++S + + L +
Sbjct: 2402 SAQPPPPPPPP--PPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAV 2459
Query: 385 NALLSSMTSSSN--------AALGPAMPYAPEKLPSPAL------TQQPQFGPQSSILAN 430
L ++ SN P +P P +PS + +P P+ ++
Sbjct: 2460 TTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPK-PVIPQ 2518
Query: 431 LMSSTIK------TPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQS-FTPQCSLIRSL 483
L ++T K P G +++ N S Y+ +SP P + +P+ S +SL
Sbjct: 2519 LPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFS--KSL 2576
Query: 484 TPT---SNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSM-----IMQQGMASSSPGATE 535
T T L S+ + P+ S S +S+ ++ A P ++E
Sbjct: 2577 TETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLVSVEPVFSVVPPVTAVEIPISSE 2636
Query: 536 PFTFGNTKPLSHFVSEP--GPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATAT 593
TF + L F + P P + PT+ Q L T A+ +TA S ++
Sbjct: 2637 Q-TFYISGALQTFSATPVTAPSSFQAAPTSVTQ--FLTTEVSKTEVSATRSTAPSVGLSS 2693
Query: 594 LQL 596
+ +
Sbjct: 2694 ISI 2696
Score = 39.3 bits (90), Expect = 0.014
Identities = 65/275 (23%), Positives = 94/275 (34%), Gaps = 49/275 (17%)
Query: 318 ATKQQGPTPSWSGLPP---PGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNT 374
A++ +PS S LP P + + PPP P PPPPPP P
Sbjct: 2373 ASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPP----------- 2421
Query: 375 LSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSS 434
P L TS L P + SP T P F +++ +
Sbjct: 2422 --------PPPPPLPPPTSPKPTIL----PKKKLTVASPVTTATPLFDAVTTLETTAVLR 2469
Query: 435 TIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQ 494
+ P + + P P P P P L P+ S P + P + Q
Sbjct: 2470 SNGLPVTRICTTAPPPVP-PKPSSIPSGLVFTHRPEPSKPP-------IAPKPVI---PQ 2518
Query: 495 QQQQQQQQANVIFKP--ISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEP 552
Q+ ++ KP +S SS TL+++ SP T PLS ++
Sbjct: 2519 LPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSP----------TSPLSPHSNKS 2568
Query: 553 GPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATAS 587
P+ S+ T +L PT + AS A S
Sbjct: 2569 SPRFSKSLTETYVVITLPSEPGTPTDSSASQAITS 2603
Score = 37.7 bits (86), Expect = 0.041
Identities = 81/369 (21%), Positives = 116/369 (31%), Gaps = 66/369 (17%)
Query: 293 LPPLPVPQWHHAHQLKALAASK------QGSATKQQGPTPSWSGLPPPGLSPPYRPVPSP 346
+P P P+ A A SK Q S K P S P P PP P+
Sbjct: 653 VPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTL 712
Query: 347 HPPPLPLPPPPP-------PFSPQSLMVSCMSSNTLSGSTLRGSPNAL--LSSMTSSSNA 397
H P PP P P+ V P + + + SSS+A
Sbjct: 713 HGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSA 772
Query: 398 ALGPAMP------YAPEKLPSPALTQQPQ----FGPQSSILANLMSSTIKTPQGHLMSAL 447
P +P A EK P T + F P ++ S I P +
Sbjct: 773 TTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPAS---DSK 829
Query: 448 PASNPGPSPPYRPEKLSSP---------GLPQQSFTPQCSLIRSLTPT--------SNLL 490
S+PGPS + +K P + S P + +PT +
Sbjct: 830 IISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTV 889
Query: 491 SQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNT-------- 542
QQ + Q+Q+ + S N Q + F FG +
Sbjct: 890 PTPQQSPKPQEQS----RRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNL 945
Query: 543 -----KPLSHFVSEPG-PQKM---PSMPTTSRQPSLLHYLQQPTPTQASSATASSTATAT 593
+P H S PG P K PS P TS+ P P P ++ + A A
Sbjct: 946 ISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAA 1005
Query: 594 LQLQQQQQQ 602
+L+ + +Q
Sbjct: 1006 EKLEPKAEQ 1014
Score = 37.4 bits (85), Expect = 0.053
Identities = 74/351 (21%), Positives = 125/351 (35%), Gaps = 53/351 (15%)
Query: 187 QDPS-PNELDLEKILGTKPEEPLVLDHPQ---ATLSTTPKPSVQMSHLESLASSKEFASS 242
++PS P+E D + KP++P ++ ++ S T KP + S ++S A K
Sbjct: 736 KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPL 795
Query: 243 CSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWH 302
+ S P + +S P SK I P+S S++ + H
Sbjct: 796 KTDSAKPSQSFPPTGEKVS---PFDSKAIPRPASD-----SKIIS--------------H 833
Query: 303 HAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSP 362
++ + K++ P + + + P +P P P P PP P P +
Sbjct: 834 PGPSSESKGQKQVDPVQKKEEPKKAQTKMSP-------KPDAKPMPKGSPTPPGPRPTAG 886
Query: 363 QSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFG 422
Q++ T + SP S S N P + P +T + FG
Sbjct: 887 QTV------------PTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGK-LFG 933
Query: 423 PQSSIL--ANLMSSTIKTPQGHLMSALPA-SNPGPSPPYRPEKLSSPGLPQQSFTPQCSL 479
+SI A+ + ST P H S A P+P P P Q+
Sbjct: 934 FGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKS 993
Query: 480 I----RSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGM 526
I + P + L + +Q ++ KP SK+L+ Q+ +
Sbjct: 994 IPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAV 1044
Score = 31.2 bits (69), Expect = 3.8
Identities = 32/138 (23%), Positives = 54/138 (39%), Gaps = 9/138 (6%)
Query: 454 PSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSN 513
PSPP P+ L SP P +P +L + P L Q+ P S
Sbjct: 3614 PSPPKSPKVLYSPISP---LSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPK 3670
Query: 514 SSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYL 573
++K +MQ+ M S P P +++ + + +M ++ Q + L
Sbjct: 3671 TAK----MMQRSM--SDPKPLSPTADESSRAPFQYTEGYTTKGSQTMTSSGAQKKVKRTL 3724
Query: 574 QQPTPTQASSATASSTAT 591
P P + S+ T S+ +T
Sbjct: 3725 PNPPPEEISTGTQSTFST 3742
Score = 30.4 bits (67), Expect = 6.5
Identities = 53/208 (25%), Positives = 70/208 (33%), Gaps = 23/208 (11%)
Query: 549 VSEPGPQKMPSMPTTSRQPSLLHYLQQP-TPTQASSATASSTATATLQLQQQQQQQQQQP 607
+ +P Q+ P P +Q LQQ TP SS + + Q Q P
Sbjct: 206 IIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTP 265
Query: 608 --DHSSFLLQQMMQQPQRFQRSV--ASDSMPALPRQGCCHLFAWTSAASSVKPQHQHGNS 663
DH+ LQ+ +PQ Q + P+LP + T KP Q
Sbjct: 266 QTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPG----KPPAQQPGH 321
Query: 664 FTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSFAHE 723
S+ P PS +T A + G + P G P Q LG A
Sbjct: 322 EKSQPGPAKPPAQPSGLTK-PLAQQPGTVKPPVQPPGTTKPPAQPLGP---------AKP 371
Query: 724 LARVTSSYSTSEAAPWGSWDPKAWRQVP 751
A+ T S S P PKA Q P
Sbjct: 372 PAQQTGSEKPSSEQP----GPKALAQPP 395
Score = 30.4 bits (67), Expect = 6.5
Identities = 40/162 (24%), Positives = 62/162 (38%), Gaps = 30/162 (18%)
Query: 392 TSSSNAALGPAMPYAPEKLPSPAL-TQQPQFGPQSSILANLMSSTIKTPQGHLMSALPAS 450
T + + + P PY + SPAL TQ P Q S + T+ Q
Sbjct: 3872 TQTESQLVPPTSPYTQYQYSSPALPTQAPTSYTQQS---HFEQQTLYHQQ---------- 3918
Query: 451 NPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKP- 509
PY+ + + + SFTPQ + P+ L SQ QQ+ +Q + +P
Sbjct: 3919 ----VSPYQTQP-TFQAVATMSFTPQVQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPK 3973
Query: 510 ISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSE 551
I+SN + + P P + NT +SH S+
Sbjct: 3974 ITSNYE----------VIRNQPLMIAPVSTDNTFAVSHLGSK 4005
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 59.3 bits (142), Expect = 1e-08
Identities = 127/551 (23%), Positives = 183/551 (33%), Gaps = 106/551 (19%)
Query: 96 GPG-------AHPSTACAELQVPPLTINPSPAAMGVAGQSLLLENNPMNGNIMGSPFVVP 148
GPG +HPS+ + T+ A G+ + +P IM P +
Sbjct: 3030 GPGPSSFPRASHPSSTASTALSTNATVM---LAAGIPVPQFISSIHPEQSVIM-PPHSIT 3085
Query: 149 QTT--------EVGLKGPTVPYY------EKINSVPAVDQELQELLEELTKIQDPSPNEL 194
QT EV + PT+P E ++S A Q Q + + P P
Sbjct: 3086 QTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPA 3145
Query: 195 DLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIP 254
+ + P E V H +T P S E L E+
Sbjct: 3146 GVPALASQHPPEEEVHYHLPVARATAPVQS------EVLVMQSEYRLH------------ 3187
Query: 255 SSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASK 314
Y++P + +V P + A S+ A V +PP A+
Sbjct: 3188 ------PYTVPRDVRIMVHPHVT-AVSEQPRAADGVVKVPP---------------ASKA 3225
Query: 315 QGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNT 374
K+ TP P P P+P P P+PLP P P ++ +++ SN
Sbjct: 3226 PQQPGKEAAKTPDAKAAPTP--------TPAPVPVPVPLPAPAPAPHGEARILTVTPSNQ 3277
Query: 375 LSGSTLRGSPNALLSSMTSSSNAALGPAMPYAP-EKLPSPALTQQPQFGPQSSILANLMS 433
L G L S+ L Y PA QF SS+ L S
Sbjct: 3278 LQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSV--GLPS 3335
Query: 434 STIKTPQGHLMSALPASNP---------GPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLT 484
T QG P P P+PP P +L PG P S PQ S T
Sbjct: 3336 RTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGT 3395
Query: 485 PT--------SNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATE- 535
T + ++ + Q Q+A P S S +S+ M+ + S P T
Sbjct: 3396 QTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPS--PVSVSMKPDLPVSLPTQTAP 3453
Query: 536 ------PFTFGNTKP----LSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSAT 585
P T G + P L H +P P++ S TS++P + L + P
Sbjct: 3454 KQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLL 3513
Query: 586 ASSTATATLQL 596
A TA +QL
Sbjct: 3514 ALKNDTAAVQL 3524
Score = 37.0 bits (84), Expect = 0.070
Identities = 57/241 (23%), Positives = 89/241 (36%), Gaps = 47/241 (19%)
Query: 266 STSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPT 325
+T+K++V+P S +Q Q P A V H + S++ +T Q T
Sbjct: 2343 NTNKKVVAPVESHVPESNQAQGESPAANEGTTV---QHPEAPQEEKQSEKPHSTPPQSCT 2399
Query: 326 PSWSGLPPPGLSPPY------RPVPSPHPPPLPLPPPPPPF--SPQS--LMVSCMSSNTL 375
S +P S P + PP LP PP P P PQ+ + S + S+ +
Sbjct: 2400 SDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPV 2459
Query: 376 SGSTLRGSPNALLSSMTS---SSNAALGPAMPYAP----------------EKLPSPAL- 415
+ + P L S+T+ S A G +P + PSPAL
Sbjct: 2460 TPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALP 2519
Query: 416 --TQQPQFGPQSSILANLM------------SSTIKTPQGHLMSALPASNPGPSPPYRPE 461
T+ SS L ++ S+++ T +SA P + P PP +
Sbjct: 2520 PDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSK 2579
Query: 462 K 462
K
Sbjct: 2580 K 2580
Score = 34.3 bits (77), Expect = 0.45
Identities = 51/277 (18%), Positives = 102/277 (36%), Gaps = 58/277 (20%)
Query: 404 PYAPEKLPS---PALTQQPQFGPQSSILANLMSSTI--------KTPQGHLMS------- 445
P PE P L P GP S + L S+ KT + L++
Sbjct: 1617 PKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEP 1676
Query: 446 ------ALPASNPGPSPPYRPEKLSSP--------------GLPQQSFTPQCSLIRSLTP 485
A PAS P P+P + E++ P G+ + S Q + + P
Sbjct: 1677 ATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPP 1736
Query: 486 TSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPL 545
T Q ++NV +P +S++ LS Q+ ++ P A +P + +P
Sbjct: 1737 TPG-------ASFSQAESNVDPEP---DSTQPLSKPAQKSEEANEPKAEKPDATADAEPD 1786
Query: 546 SHFVSEPGPQKM----------PSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQ 595
++ +E P+ P + ++P+ + P A S + +
Sbjct: 1787 ANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSER 1846
Query: 596 LQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDS 632
+ +++ ++ P + L ++ + ++ R+ + +S
Sbjct: 1847 IDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNS 1883
>gi|119943102 CREB binding protein isoform b [Homo sapiens]
Length = 2404
Score = 58.5 bits (140), Expect = 2e-08
Identities = 126/517 (24%), Positives = 171/517 (33%), Gaps = 106/517 (20%)
Query: 260 ISYSIPSTSKQIVSPSSSMAQSKSQV----QAMLPVALPPLPVPQWHHAHQLKALAASKQ 315
I+ S+P + +P S MA V Q PV +P +P QW A
Sbjct: 1939 INNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPV-MPSMPPGQWQQA----------- 1986
Query: 316 GSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTL 375
QQ P P GLP P +S + + P +P PP SP +L + +
Sbjct: 1987 --PLPQQQPMP---GLPRPVISMQAQAAVAG--PRMPSVQPPRSISPSALQDLLRTLKSP 2039
Query: 376 SGSTLRGSPNALLSS----MTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANL 431
S + +L S M + + P P P L QP PQ +
Sbjct: 2040 SSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMH--- 2096
Query: 432 MSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSN--- 488
+ P ++A+ A P P P P++ + GL PQ + + P N
Sbjct: 2097 -----QQPSLQNLNAMQAGVPRPGVP--PQQQAMGGL-----NPQGQALNIMNPGHNPNM 2144
Query: 489 --------------LLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMAS------ 528
LL QQQQQQQQQQQ + S M GMA
Sbjct: 2145 ASMNPQYREMLRRQLLQQQQQQQQQQQQ---------QQQQQQGSAGMAGGMAGHGQFQQ 2195
Query: 529 -SSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATAS 587
PG P + H P + SM + Q L + QP A
Sbjct: 2196 PQGPGGYPPAMQQQQRMQQHL-----PLQGSSMGQMAAQMGQLGQMGQP------GLGAD 2244
Query: 588 STATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQ----GCCH 643
ST LQQ+ QQQQ Q PQ+ S LP Q +
Sbjct: 2245 STPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLS-GQPQASHLPGQQIATSLSN 2303
Query: 644 LFAWTSAASSVKPQHQHGNSFTS---RQDPQPGDVSPSN-----------ITHVDKACKL 689
+ S +PQ Q +S S + P P VSP + +D+ L
Sbjct: 2304 QVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQG-HL 2362
Query: 690 GEARHPQVSLGRQPPSCQALGSESFLPGSSFAHELAR 726
G + PS AL SE L G + L +
Sbjct: 2363 GNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEK 2399
Score = 57.8 bits (138), Expect = 4e-08
Identities = 94/383 (24%), Positives = 139/383 (36%), Gaps = 75/383 (19%)
Query: 305 HQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQS 364
H+L+ ++ AT P S LP P +PP P P P P PP P SP S
Sbjct: 1819 HRLQQAQLMRRRMATMNTRNVPQQS-LPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVS 1877
Query: 365 LMVSCMSSNTLSGSTLRGSPNALLSS--MTSSSNAALGPAMP-----YAPEKLPSPALTQ 417
+ S S R P +S+ TS A PA P A ++ A Q
Sbjct: 1878 M------SPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQ 1931
Query: 418 QPQF---------------GPQSSILANLMSSTIKTPQ--GHLMSALPASNPGPSPPYRP 460
Q + G S +A + + + Q G +M ++P +P P
Sbjct: 1932 QHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAP--LP 1989
Query: 461 EKLSSPGLPQQSFTPQCSLI------------RSLTPTS-----NLLSQQQQQQQQQQQA 503
++ PGLP+ + Q RS++P++ L QQQQQ
Sbjct: 1990 QQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVL 2049
Query: 504 NVIFKP-------ISSNSSKTLS----MIMQQGMASS-----SPGATEPFTFGNTKPLSH 547
N++ I ++K ++ M Q G+ S PG + + N +
Sbjct: 2050 NILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQA 2109
Query: 548 FVSEPG-PQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQ 606
V PG P + +M + Q L+ + +S QL QQQQQQQQQ
Sbjct: 2110 GVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQ 2169
Query: 607 PDHSSFLLQQMMQQPQRFQRSVA 629
QQ QQ Q+ +A
Sbjct: 2170 --------QQQQQQQQQGSAGMA 2184
Score = 51.6 bits (122), Expect = 3e-06
Identities = 71/320 (22%), Positives = 124/320 (38%), Gaps = 16/320 (5%)
Query: 163 YEKINSVPAVDQELQELLEELTK-IQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTP 221
YE NS L E + ++ K +++ + L + ILG +P P P P
Sbjct: 603 YESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQP 662
Query: 222 --KPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMA 279
P+ +S + + +S + ++ ++Q+P + G + P ++ S+
Sbjct: 663 VRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVP 722
Query: 280 QSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPP 339
A+ P +P P H + + A A ++ + Q P+ S + G P
Sbjct: 723 G-----MAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPA 777
Query: 340 YRPVPSPHPPPLPLPPPPPPFSPQSLMVSC--MSSNTLSGSTLRGSPNALLSSMTSSSNA 397
V P LP P PQ+ + C ++ + L + S A + S+ ++
Sbjct: 778 QTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPP 837
Query: 398 ALGPAMPYAPEKLPSPALT--QQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPS 455
+ P P AP + +P + Q P P S A ST T Q +A P P
Sbjct: 838 GMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQST-PTVQA---AAQAQVTPQPQ 893
Query: 456 PPYRPEKLSSPGLPQQSFTP 475
P +P +++P QQ TP
Sbjct: 894 TPVQPPSVATPQSSQQQPTP 913
Score = 47.8 bits (112), Expect = 4e-05
Identities = 76/308 (24%), Positives = 107/308 (34%), Gaps = 32/308 (10%)
Query: 314 KQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSP-HPP--PLPLPPPPPPFSPQSLMVSCM 370
K+ S +QG + LP PG PP P P PP PL LP S + M
Sbjct: 630 KRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPM 689
Query: 371 SSNTLSGSTLRGSPNALLSSMTSSSNAALG--PAMPYAPEKLPSPALTQQPQFGPQSSIL 428
S + P A S ++G P M +P ++P P ++++
Sbjct: 690 SLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQP---PNMMGAHTNNMM 746
Query: 429 ANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSN 488
A + + PQ S+ A + G P +S Q P +L L N
Sbjct: 747 AQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVS------QGQVPGAALPNPL----N 796
Query: 489 LLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHF 548
+L Q Q P +S M Q ++ PG T P T+P +
Sbjct: 797 MLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQ--HTTPPGMTPPQPAAPTQPSTPV 854
Query: 549 VSE-----PGPQKMPSMPTTSRQPSLLHYLQ-QPTPTQASSATASSTATATLQLQQQQQQ 602
S P P +PS T P++ Q Q TP + S AT Q Q
Sbjct: 855 SSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVAT------PQSSQ 908
Query: 603 QQQQPDHS 610
QQ P H+
Sbjct: 909 QQPTPVHA 916
Score = 31.2 bits (69), Expect = 3.8
Identities = 35/156 (22%), Positives = 60/156 (38%), Gaps = 37/156 (23%)
Query: 492 QQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSE 551
+QQQ Q + QQA ++ + +++ +++ + S+ PG
Sbjct: 1813 RQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGT------------------ 1854
Query: 552 PGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSA-----------TASSTATATLQLQQQQ 600
P + PS P T + P+ QP+P S A T ST T Q+
Sbjct: 1855 --PTQQPSTPQTPQPPA----QPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPP 1908
Query: 601 QQQQQQPD--HSSFLLQQMMQQPQRFQRSVASDSMP 634
Q P ++ +++ QQ Q R ++SMP
Sbjct: 1909 PPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMP 1944
>gi|119943104 CREB binding protein isoform a [Homo sapiens]
Length = 2442
Score = 58.5 bits (140), Expect = 2e-08
Identities = 126/517 (24%), Positives = 171/517 (33%), Gaps = 106/517 (20%)
Query: 260 ISYSIPSTSKQIVSPSSSMAQSKSQV----QAMLPVALPPLPVPQWHHAHQLKALAASKQ 315
I+ S+P + +P S MA V Q PV +P +P QW A
Sbjct: 1977 INNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPV-MPSMPPGQWQQA----------- 2024
Query: 316 GSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTL 375
QQ P P GLP P +S + + P +P PP SP +L + +
Sbjct: 2025 --PLPQQQPMP---GLPRPVISMQAQAAVAG--PRMPSVQPPRSISPSALQDLLRTLKSP 2077
Query: 376 SGSTLRGSPNALLSS----MTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANL 431
S + +L S M + + P P P L QP PQ +
Sbjct: 2078 SSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMH--- 2134
Query: 432 MSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSN--- 488
+ P ++A+ A P P P P++ + GL PQ + + P N
Sbjct: 2135 -----QQPSLQNLNAMQAGVPRPGVP--PQQQAMGGL-----NPQGQALNIMNPGHNPNM 2182
Query: 489 --------------LLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMAS------ 528
LL QQQQQQQQQQQ + S M GMA
Sbjct: 2183 ASMNPQYREMLRRQLLQQQQQQQQQQQQ---------QQQQQQGSAGMAGGMAGHGQFQQ 2233
Query: 529 -SSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATAS 587
PG P + H P + SM + Q L + QP A
Sbjct: 2234 PQGPGGYPPAMQQQQRMQQHL-----PLQGSSMGQMAAQMGQLGQMGQP------GLGAD 2282
Query: 588 STATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQ----GCCH 643
ST LQQ+ QQQQ Q PQ+ S LP Q +
Sbjct: 2283 STPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLS-GQPQASHLPGQQIATSLSN 2341
Query: 644 LFAWTSAASSVKPQHQHGNSFTS---RQDPQPGDVSPSN-----------ITHVDKACKL 689
+ S +PQ Q +S S + P P VSP + +D+ L
Sbjct: 2342 QVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQG-HL 2400
Query: 690 GEARHPQVSLGRQPPSCQALGSESFLPGSSFAHELAR 726
G + PS AL SE L G + L +
Sbjct: 2401 GNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEK 2437
Score = 57.8 bits (138), Expect = 4e-08
Identities = 94/383 (24%), Positives = 139/383 (36%), Gaps = 75/383 (19%)
Query: 305 HQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQS 364
H+L+ ++ AT P S LP P +PP P P P P PP P SP S
Sbjct: 1857 HRLQQAQLMRRRMATMNTRNVPQQS-LPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVS 1915
Query: 365 LMVSCMSSNTLSGSTLRGSPNALLSS--MTSSSNAALGPAMP-----YAPEKLPSPALTQ 417
+ S S R P +S+ TS A PA P A ++ A Q
Sbjct: 1916 M------SPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQ 1969
Query: 418 QPQF---------------GPQSSILANLMSSTIKTPQ--GHLMSALPASNPGPSPPYRP 460
Q + G S +A + + + Q G +M ++P +P P
Sbjct: 1970 QHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAP--LP 2027
Query: 461 EKLSSPGLPQQSFTPQCSLI------------RSLTPTS-----NLLSQQQQQQQQQQQA 503
++ PGLP+ + Q RS++P++ L QQQQQ
Sbjct: 2028 QQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVL 2087
Query: 504 NVIFKP-------ISSNSSKTLS----MIMQQGMASS-----SPGATEPFTFGNTKPLSH 547
N++ I ++K ++ M Q G+ S PG + + N +
Sbjct: 2088 NILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQA 2147
Query: 548 FVSEPG-PQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQ 606
V PG P + +M + Q L+ + +S QL QQQQQQQQQ
Sbjct: 2148 GVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQ 2207
Query: 607 PDHSSFLLQQMMQQPQRFQRSVA 629
QQ QQ Q+ +A
Sbjct: 2208 --------QQQQQQQQQGSAGMA 2222
Score = 51.6 bits (122), Expect = 3e-06
Identities = 71/320 (22%), Positives = 124/320 (38%), Gaps = 16/320 (5%)
Query: 163 YEKINSVPAVDQELQELLEELTK-IQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTP 221
YE NS L E + ++ K +++ + L + ILG +P P P P
Sbjct: 641 YESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQP 700
Query: 222 --KPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMA 279
P+ +S + + +S + ++ ++Q+P + G + P ++ S+
Sbjct: 701 VRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVP 760
Query: 280 QSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPP 339
A+ P +P P H + + A A ++ + Q P+ S + G P
Sbjct: 761 G-----MAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPA 815
Query: 340 YRPVPSPHPPPLPLPPPPPPFSPQSLMVSC--MSSNTLSGSTLRGSPNALLSSMTSSSNA 397
V P LP P PQ+ + C ++ + L + S A + S+ ++
Sbjct: 816 QTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPP 875
Query: 398 ALGPAMPYAPEKLPSPALT--QQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPS 455
+ P P AP + +P + Q P P S A ST T Q +A P P
Sbjct: 876 GMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQST-PTVQA---AAQAQVTPQPQ 931
Query: 456 PPYRPEKLSSPGLPQQSFTP 475
P +P +++P QQ TP
Sbjct: 932 TPVQPPSVATPQSSQQQPTP 951
Score = 47.8 bits (112), Expect = 4e-05
Identities = 76/308 (24%), Positives = 107/308 (34%), Gaps = 32/308 (10%)
Query: 314 KQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSP-HPP--PLPLPPPPPPFSPQSLMVSCM 370
K+ S +QG + LP PG PP P P PP PL LP S + M
Sbjct: 668 KRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPM 727
Query: 371 SSNTLSGSTLRGSPNALLSSMTSSSNAALG--PAMPYAPEKLPSPALTQQPQFGPQSSIL 428
S + P A S ++G P M +P ++P P ++++
Sbjct: 728 SLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQP---PNMMGAHTNNMM 784
Query: 429 ANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSN 488
A + + PQ S+ A + G P +S Q P +L L N
Sbjct: 785 AQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVS------QGQVPGAALPNPL----N 834
Query: 489 LLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHF 548
+L Q Q P +S M Q ++ PG T P T+P +
Sbjct: 835 MLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQ--HTTPPGMTPPQPAAPTQPSTPV 892
Query: 549 VSE-----PGPQKMPSMPTTSRQPSLLHYLQ-QPTPTQASSATASSTATATLQLQQQQQQ 602
S P P +PS T P++ Q Q TP + S AT Q Q
Sbjct: 893 SSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVAT------PQSSQ 946
Query: 603 QQQQPDHS 610
QQ P H+
Sbjct: 947 QQPTPVHA 954
Score = 31.2 bits (69), Expect = 3.8
Identities = 35/156 (22%), Positives = 60/156 (38%), Gaps = 37/156 (23%)
Query: 492 QQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSE 551
+QQQ Q + QQA ++ + +++ +++ + S+ PG
Sbjct: 1851 RQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGT------------------ 1892
Query: 552 PGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSA-----------TASSTATATLQLQQQQ 600
P + PS P T + P+ QP+P S A T ST T Q+
Sbjct: 1893 --PTQQPSTPQTPQPPA----QPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPP 1946
Query: 601 QQQQQQPD--HSSFLLQQMMQQPQRFQRSVASDSMP 634
Q P ++ +++ QQ Q R ++SMP
Sbjct: 1947 PPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMP 1982
>gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens]
Length = 1426
Score = 58.5 bits (140), Expect = 2e-08
Identities = 88/368 (23%), Positives = 132/368 (35%), Gaps = 53/368 (14%)
Query: 211 DHPQATLSTTPKPSVQMSH-----------LESLASSKEFASSCSQVTGMSLQIPSSSTG 259
+HPQ P+P + MS E + + S S + + L S+ T
Sbjct: 771 EHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTS 830
Query: 260 ISYSIPS-------------TSKQIVSPSSSMAQSKSQVQAMLPVALPP---LPVPQWHH 303
++ + P Q+ SP + +S + Q P+ P L PQ
Sbjct: 831 LNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQT-- 888
Query: 304 AHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPP-PPPPFSP 362
QL + A +A+ + P + P L P P PSP P PP P P
Sbjct: 889 PSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPP 948
Query: 363 QSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSN--AALGPAMPYAPEKLPSPALTQQPQ 420
M+S + G+ G P +S +S N +L + PY P P L+Q P
Sbjct: 949 NHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMP--PEPTLSQNPL 1006
Query: 421 FGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSS----PGLPQQSFTPQ 476
S + M S+ TP H AS+ SPP R L S PG+ + P+
Sbjct: 1007 SIMMSRMSKFAMPSS--TPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPR 1064
Query: 477 CSLIRSLTPTSNL----LSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSP- 531
S + P L ++Q Q N + I + + M G+ S +P
Sbjct: 1065 ISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPH-----GVPMGPGLMSHNPI 1119
Query: 532 ---GATEP 536
G+ EP
Sbjct: 1120 MGHGSQEP 1127
Score = 50.1 bits (118), Expect = 8e-06
Identities = 80/326 (24%), Positives = 114/326 (34%), Gaps = 59/326 (18%)
Query: 280 QSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATK---QQGPTPSWSGLPPPGL 336
Q+ SQ + P PP+P P A + L G K G S + LPP G
Sbjct: 246 QNSSQNTRLQPT--PPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGT 303
Query: 337 SPPYRPVPSPHPPPL---------PLPPPPPPFS----------PQSLMVSCMSSNTLSG 377
P P P P PPPPP S P L + S
Sbjct: 304 GPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSL 363
Query: 378 STLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTI- 436
TLR L + A G P++ +P + PQ P+ I A + S
Sbjct: 364 QTLRDIQRMLFPDEKEFTGAQSG-----GPQQ--NPGVLDGPQKKPEGPIQAMMAQSQSL 416
Query: 437 -KTPQGHLMSALPASNPGPSP-PYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNL---LS 491
K P P G P+ P+++ P + QS T + +TP L
Sbjct: 417 GKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQ 476
Query: 492 QQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQG-------------MASS---SPGATE 535
Q+ ++++++Q V+ + S M+ Q G M S +PG TE
Sbjct: 477 QEFYEEKRRKQEQVVVQQCSLQDM----MVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTE 532
Query: 536 PFTFGNTKPLSHFVSEPGPQKMPSMP 561
PF+ G P H + G P+MP
Sbjct: 533 PFSDGINMP--HSLPPRGMAPHPNMP 556
Score = 30.8 bits (68), Expect = 5.0
Identities = 45/181 (24%), Positives = 66/181 (36%), Gaps = 30/181 (16%)
Query: 320 KQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMV--SCMSSNTLSG 377
K Q + + P + P PS H P P +P ++ S +N +
Sbjct: 132 KSQDSQHTPHSMTPSNATAPRSSTPS-HGQTTATEPTPAQKTPAKVVYVFSTEMANKAAE 190
Query: 378 STLRGSPNALLS--------SMTSSSNAALGP---AMPYAPEKLPS--PALTQQPQFGPQ 424
+ L+G ++S + T S A L A+ P+ LP PA Q Q Q
Sbjct: 191 AVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQ 250
Query: 425 SSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLT 484
++ L TP +PA P P+ P RP SPG+ + P S T
Sbjct: 251 NTRLQ-------PTPP------IPAPAPKPAAPPRPLDRESPGV-ENKLIPSVGSPASST 296
Query: 485 P 485
P
Sbjct: 297 P 297
Score = 30.4 bits (67), Expect = 6.5
Identities = 39/178 (21%), Positives = 63/178 (35%), Gaps = 15/178 (8%)
Query: 189 PSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTG 248
P+ ++ I G+ P P+ TLS P S+ MS + A +
Sbjct: 973 PTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPL-SIMMSRMSKFAMPSSTPLYHDAIKT 1031
Query: 249 MSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLK 308
++ S S ++PS + P + ++ PV +P+P +
Sbjct: 1032 VASSDDDSPPARSPNLPSMNNM---PGMGINTQNPRISGPNPV----VPMPTLSPMGMTQ 1084
Query: 309 ALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLM 366
L+ S Q + GP +PP G+ P P H P + PP PQ M
Sbjct: 1085 PLSHSNQMPSPNAVGPN-----IPPHGV--PMGPGLMSHNPIMGHGSQEPPMVPQGRM 1135
>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
tract binding protein associated) [Homo sapiens]
Length = 707
Score = 58.5 bits (140), Expect = 2e-08
Identities = 53/183 (28%), Positives = 73/183 (39%), Gaps = 28/183 (15%)
Query: 294 PPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPL 353
PP+P P H +QQ P P PPP PP++P P P P
Sbjct: 58 PPIPPPPPHQ----------------QQQQPPPQQ---PPPQQPPPHQPPPHPQPHQQQQ 98
Query: 354 PPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNA-LLSSMTSSSNAALGPAMPYAPEKLPS 412
PPPPP S + ++ GS S +A + TS + GP P P
Sbjct: 99 PPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGP----GPTPTPP 154
Query: 413 PALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQS 472
PA+T P P + ++ + +T PQ PA+ PGP P P++ PG P+
Sbjct: 155 PAVTSAPPGAPPPTPPSSGVPTT--PPQAGGPPPPPAAVPGPGP--GPKQGPGPGGPKGG 210
Query: 473 FTP 475
P
Sbjct: 211 KMP 213
>gi|58530876 melanoma antigen family C, 1 [Homo sapiens]
Length = 1142
Score = 57.8 bits (138), Expect = 4e-08
Identities = 105/452 (23%), Positives = 161/452 (35%), Gaps = 63/452 (13%)
Query: 196 LEKILGTKPE--EPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMS-LQ 252
L IL + PE + PQ+ L S + L SS E S + S LQ
Sbjct: 420 LLSILQSSPESAQSAFEGFPQSPLQIPVSSSFSYTLLSLFQSSPERTHSTFEGFPQSPLQ 479
Query: 253 IPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAA 312
IP SS+ S ST + S QS + P+ +P P P+ + H +
Sbjct: 480 IPVSSSSSS----STLLSLFQSSPECTQSTFEGFPQSPLQIPQSP-PEGENTHSPLQIVP 534
Query: 313 S-------------KQGSATKQQGPTPSWSGLPPP----GLSPPYRPVPSPHPPPLPLP- 354
S Q + +P + PP LSP Y P SP P
Sbjct: 535 SLPEWEDSLSPHYFPQSPPQGEDSLSPHYFPQSPPQGEDSLSPHYFP-QSPQGEDSLSPH 593
Query: 355 --PPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMP-------- 404
P PP S+ + L G + S + +S +SS+ ++L + P
Sbjct: 594 YFPQSPPQGEDSMSPLYFPQSPLQGEEFQSSLQSPVSICSSSTPSSLPQSFPESSQSPPE 653
Query: 405 -------YAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMS--ALPASNPGPS 455
++P+ P +Q P P+S+ S ++ PQ L +L + + S
Sbjct: 654 GPVQSPLHSPQSPPEGMHSQSPLQSPESAPEGEDSLSPLQIPQSPLEGEDSLSSLHFPQS 713
Query: 456 PPYRPEKLSSPGLPQQSFTPQ--------------CSLIRSLTPTSNLLSQQQQQQQQQQ 501
PP + LS PQ F PQ CS SL+ + Q +
Sbjct: 714 PPEWEDSLSPLHFPQ--FPPQGEDFQSSLQSPVSICSSSTSLSLPQSFPESPQSPPEGPA 771
Query: 502 QANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMP 561
Q+ + +P+SS S TL+ ++Q S P P+S F S S P
Sbjct: 772 QSP-LQRPVSSFFSYTLASLLQSSHESPQSPPEGPAQSPLQSPVSSFPSSTSSSLSQSSP 830
Query: 562 TTSRQPSLLHYLQQPTPTQASSATASSTATAT 593
+S S L + +P + S +++T
Sbjct: 831 VSSFPSSTSSSLSKSSPESPLQSPVISFSSST 862
Score = 50.8 bits (120), Expect = 5e-06
Identities = 108/439 (24%), Positives = 152/439 (34%), Gaps = 81/439 (18%)
Query: 217 LSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSS 276
+ T PS+ S ES S E S S LQIP SS T + SP S
Sbjct: 6 MPTAGMPSLLQSSSESPQSCPEGEDSQSP-----LQIPQSSP----ESDDTLYPLQSPQS 56
Query: 277 SMAQSKSQVQAMLPV----ALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLP 332
S P + PL +PQ +S +G T+ +P +
Sbjct: 57 RSEGEDSSDPLQRPPEGKDSQSPLQIPQ-----------SSPEGDDTQ----SPLQNSQS 101
Query: 333 PPGLSPPYRPVPSPHPPP------LPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNA 386
P P+ PP PL P F +L+ SS + S G P +
Sbjct: 102 SPEGKDSLSPLEISQSPPEGEDVQSPLQNPASSFFSSALLSIFQSSPESTQSPFEGFPQS 161
Query: 387 LLS-SMTSSSNAALGPAMPYAPEKLPSP--ALTQQPQFGPQSSILANLMSSTIKTPQGHL 443
+L ++++S++ L +PE SP Q P P S ++ + S ++
Sbjct: 162 VLQIPVSAASSSTLVSIFQSSPESTQSPFEGFPQSPLQIPVSRSFSSTLLSIFQSSPERT 221
Query: 444 MSALPASNPGPSP-PYRPEKLSSPGLPQQSFTP----------QCSLIRSLTPT--SNLL 490
S P P P S+ QSF+ Q SL ++P+ S L+
Sbjct: 222 QSTFEGFAQSPLQIPVSPSSSSTLLSLFQSFSERTQSTFEGFAQSSLQIPVSPSFSSTLV 281
Query: 491 SQQQQQQQQQQQANVIFK------PISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKP 544
S Q ++ Q F P+SS+SS TL + Q SSP T
Sbjct: 282 SLFQSSPERTQSTFEGFPQSPLQIPVSSSSSSTLLSLFQ-----SSPERT---------- 326
Query: 545 LSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQQ 604
H E PQ + +P TS S L + Q +P A S Q Q
Sbjct: 327 --HSTFEGFPQSLLQIPMTSSFSSTLLSIFQSSPESAQSTFEG--------FPQSPLQIP 376
Query: 605 QQPDHSSFLLQQMMQQPQR 623
P SS LL P+R
Sbjct: 377 GSPSFSSTLLSLFQSSPER 395
Score = 48.5 bits (114), Expect = 2e-05
Identities = 76/282 (26%), Positives = 112/282 (39%), Gaps = 31/282 (10%)
Query: 250 SLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKA 309
SLQ P S S S PS+ Q P SS + + VQ+ P+ P P H L++
Sbjct: 624 SLQSPVSIC--SSSTPSSLPQSF-PESSQSPPEGPVQS--PLHSPQSPPEGMHSQSPLQS 678
Query: 310 LAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSC 369
++ +G + P LS + P P P P F PQ
Sbjct: 679 PESAPEGEDSLSPLQIPQSPLEGEDSLSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQ- 737
Query: 370 MSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILA 429
S+L+ SP ++ SS TS S P P +P + P+ + Q+P S LA
Sbjct: 738 --------SSLQ-SPVSICSSSTSLSLPQSFPESPQSPPEGPAQSPLQRPVSSFFSYTLA 788
Query: 430 NLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNL 489
+L+ S+ ++PQ P P SP P S P S + + + TS+
Sbjct: 789 SLLQSSHESPQS------PPEGPAQSPLQSPVS-SFPSSTSSSLSQSSPVSSFPSSTSSS 841
Query: 490 LSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSP 531
LS+ + Q IS +SS +LS ++ SSSP
Sbjct: 842 LSKSSPESPLQSPV------ISFSSSTSLSPFSEE---SSSP 874
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 57.4 bits (137), Expect = 5e-08
Identities = 67/278 (24%), Positives = 100/278 (35%), Gaps = 61/278 (21%)
Query: 261 SYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKA--LAASKQGSA 318
SY P S SPS S ++ LPP P + + LA K+ S
Sbjct: 245 SYPPPPQSDSASSPSPSFSEDN----------LPPPPAEFSYPVDNQRGSGLAGPKRSSV 294
Query: 319 TKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLP---LPPPPPPFSPQSLMVSCMSSNTL 375
P P+ PPG P + P P+P PPP P +PPPPPP
Sbjct: 295 VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVG-------------- 340
Query: 376 SGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPAL-TQQPQFGPQSSILANLMSS 434
GSP P P P P P P P ++ L
Sbjct: 341 -----FGSPGT--------------PPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPP 381
Query: 435 TIKTPQGHL-MSALPASNPGPSPPYRPEKLSSPGLP---QQSFTPQCSLIRSLTPTSNLL 490
+ P G P PGP PP P +P + P+ SL S+LL
Sbjct: 382 PLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLL 441
Query: 491 S--------QQQQQQQQQQQANVIFKPISSNSSKTLSM 520
S ++ ++Q++Q++ +V+ +++ S+ +++
Sbjct: 442 SAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAV 479
Score = 51.2 bits (121), Expect = 4e-06
Identities = 45/161 (27%), Positives = 63/161 (39%), Gaps = 14/161 (8%)
Query: 213 PQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIV 272
PQ+ +++P PS +L + EF+ G L P S+ +S S P + +
Sbjct: 250 PQSDSASSPSPSFSEDNLPPPPA--EFSYPVDNQRGSGLAGPKRSSVVSPSHPPPAPPLG 307
Query: 273 SPSSSMA------QSKSQVQAMLPVALPPLPV----PQWHHAHQLKALAASKQGSATKQQ 322
SP M+ + PP PV P + +A
Sbjct: 308 SPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPP 367
Query: 323 GPTPS--WSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFS 361
P P+ + LPPP LS P P P PPP P PPPPPF+
Sbjct: 368 PPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFT 408
>gi|50428940 mediator complex subunit 25 [Homo sapiens]
Length = 747
Score = 57.4 bits (137), Expect = 5e-08
Identities = 56/178 (31%), Positives = 75/178 (42%), Gaps = 23/178 (12%)
Query: 265 PSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKA--LAASKQGSATKQQ 322
P SKQ V P A S + + A LPP+P PQ+ L A +AA A K Q
Sbjct: 238 PLQSKQPV-PLPPAAPSGATLSAAPQQPLPPVP-PQYQVPGNLSAAQVAAQNAVEAAKNQ 295
Query: 323 --GPTPSWSGLPP-----PGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTL 375
G P +S + P PG+ PP+ P+P PP P P PP + Q +VS ++
Sbjct: 296 KAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPG-- 353
Query: 376 SGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMS 433
SG P A + T + G PSPA P G Q S+ L++
Sbjct: 354 SGLAPTAQPGAPSMAGTVAPGGVSG----------PSPAQLGAPALGGQQSVSNKLLA 401
Score = 43.1 bits (100), Expect = 0.001
Identities = 62/255 (24%), Positives = 96/255 (37%), Gaps = 20/255 (7%)
Query: 259 GISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQW-HHAHQLKALAASKQGS 317
GI +SI S K P+ + K+ A+L PP V Q H ++ L G
Sbjct: 177 GIHFSIVSPRKL---PALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGG 233
Query: 318 ATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTL-- 375
+ GP S +P P +P + + PLP P PP P +L + +++
Sbjct: 234 SAP--GPLQSKQPVPLPPAAPSGATLSAAPQQPLP-PVPPQYQVPGNLSAAQVAAQNAVE 290
Query: 376 SGSTLRGSPNALLSSMTSSSNAALGPAMPY----APEKLPSPALTQQPQFGPQSSILANL 431
+ + S +T AA G P+ AP+ P P +P Q S+++ +
Sbjct: 291 AAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTV 350
Query: 432 M--SSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNL 489
S T Q S PG P +L +P L Q S+ L S +
Sbjct: 351 APGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ-----SVSNKLLAWSGV 405
Query: 490 LSQQQQQQQQQQQAN 504
L Q++ + AN
Sbjct: 406 LEWQEKPKPASVDAN 420
Score = 31.6 bits (70), Expect = 2.9
Identities = 43/181 (23%), Positives = 68/181 (37%), Gaps = 33/181 (18%)
Query: 401 PAMPYAPEKLPSPALTQQPQFGPQSSI------LANLMSSTIKTPQGHLMSALPASNPGP 454
PA+ EK PAL + Q P + + + + + G L + P P
Sbjct: 189 PALRLLFEKAAPPALLEPLQ--PPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVP 246
Query: 455 SPPYRPEKLSSPGLPQQSF---TPQCSLIRSLTPTSNLLSQQQQQQQQQQQANV--IFKP 509
PP P + PQQ PQ + +L+ + + +Q + + Q+A + F P
Sbjct: 247 LPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLS-AAQVAAQNAVEAAKNQKAGLGPRFSP 305
Query: 510 ISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSL 569
I+ + ++PG PF+ L PGP P P S QPSL
Sbjct: 306 ITP-------------LQQAAPGVGPPFSQAPAPQL-----PPGPPGAPKPPPAS-QPSL 346
Query: 570 L 570
+
Sbjct: 347 V 347
Score = 31.2 bits (69), Expect = 3.8
Identities = 27/79 (34%), Positives = 35/79 (44%), Gaps = 7/79 (8%)
Query: 294 PPLPV--PQWHHAH-QLKALAASKQGSATKQQGPTPSWSGLPPPG----LSPPYRPVPSP 346
PP P+ PQ A+ QL++L + T P S L PPG L PP++ + P
Sbjct: 630 PPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQP 689
Query: 347 HPPPLPLPPPPPPFSPQSL 365
P L PPP P L
Sbjct: 690 QLGPPLLHPPPAQSWPAQL 708
Score = 30.8 bits (68), Expect = 5.0
Identities = 42/132 (31%), Positives = 48/132 (36%), Gaps = 27/132 (20%)
Query: 294 PPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLP- 352
PP P PQ + AS AT Q P P + PPPG S PPP P
Sbjct: 587 PPQPQPQG-------TVGAS---GATGQ--PQPQGTAQPPPGAPQGPPGAASGPPPPGPI 634
Query: 353 LPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPS 412
L P P +PQ + + N T P A L + P AP LP
Sbjct: 635 LRPQNPGANPQ---LRSLLLNPPPPQTGVPPPQASLHHLQP----------PGAPALLPP 681
Query: 413 PAL-TQQPQFGP 423
P QPQ GP
Sbjct: 682 PHQGLGQPQLGP 693
Score = 30.0 bits (66), Expect = 8.5
Identities = 37/129 (28%), Positives = 45/129 (34%), Gaps = 16/129 (12%)
Query: 333 PPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMT 392
PPGL P P L L PP P PQ + + SG+T + P
Sbjct: 565 PPGLGPILEDQARPSQNLLQLRPPQP--QPQGTVGA-------SGATGQPQPQGTAQPPP 615
Query: 393 SSSNAALGPAMPYAPEKLPSPAL-TQQPQFGPQ-SSILAN--LMSSTIKTPQGHLMSALP 448
+ G A P P P L Q P PQ S+L N + + PQ L P
Sbjct: 616 GAPQGPPGAASGPPP---PGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQP 672
Query: 449 ASNPGPSPP 457
P PP
Sbjct: 673 PGAPALLPP 681
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 57.0 bits (136), Expect = 7e-08
Identities = 88/382 (23%), Positives = 139/382 (36%), Gaps = 62/382 (16%)
Query: 227 MSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSM-----AQS 281
M++ E+L + E A + ++ S++ SSS+ I S + S Q S S +S
Sbjct: 511 MNYQEALKRT-ESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRS 569
Query: 282 KSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPP----PGLS 337
+S V ++ A W QL+ + ++ S + P S +PP P +
Sbjct: 570 QSIVSSVFSEA--------WKRGTQLEESSKARMESMNR-----PYTSLVPPLSPQPKIV 616
Query: 338 PPYR------PVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSM 391
PY P+P P PPP P PPPPPP P S S+ + + ++ S L +
Sbjct: 617 TPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNA 676
Query: 392 TSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASN 451
+ S A P P+P + Q PQ I P ++ P
Sbjct: 677 SQHSGALFKP---------PTPPVMQSQSVKPQ-----------ILVPPNGVVPPPPPPP 716
Query: 452 PGPSPPYRPEKLS----SPGLPQQSFTPQCSLIRSL-------TPTSNLLSQQQQQQQQQ 500
P P+P +L +P LPQ S P I + PT Q
Sbjct: 717 PPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQ 776
Query: 501 QQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSM 560
+ + S+KT++ ++ Q + P P S+ P +P
Sbjct: 777 APPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVP 836
Query: 561 PTTSRQPSLLHYLQQPTPTQAS 582
P T P + +P P+ S
Sbjct: 837 PPT--LPKQQSFCAKPPPSPLS 856
Score = 56.2 bits (134), Expect = 1e-07
Identities = 65/248 (26%), Positives = 94/248 (37%), Gaps = 42/248 (16%)
Query: 263 SIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQ 322
S+P S Q +QV P PP+P P A K L ++TK
Sbjct: 736 SLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPP-KPLVTIPAPTSTKTV 794
Query: 323 GPTPSWSGLPPPGLSPPYRPV------------PSPHPPPLPLPPP-------------P 357
P + + P P +PP P PSP PP+P+PPP P
Sbjct: 795 APVVTQAAPPTP--TPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPP 852
Query: 358 PPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQ 417
P SP +V ++S T P A+ S A + P P PA+
Sbjct: 853 SPLSPVPSVVKQIASQFPPPPT----PPAMESQPLKPVPANVAPQSP--------PAVKA 900
Query: 418 QPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQC 477
+P++ P SSI P+ L+ P +P P+PP P +SP P +S +P
Sbjct: 901 KPKWQP-SSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASP-TPDKSGSPGK 958
Query: 478 SLIRSLTP 485
++ +P
Sbjct: 959 KTSKTSSP 966
Score = 55.8 bits (133), Expect = 1e-07
Identities = 54/216 (25%), Positives = 76/216 (35%), Gaps = 29/216 (13%)
Query: 263 SIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQ 322
++P P S V + PP P P + LK + A+ +
Sbjct: 839 TLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAV 898
Query: 323 GPTPSWSG----LPPPGLSPP------YRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSS 372
P W +P P PP P P P P P P PPPPP SP
Sbjct: 899 KAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPT--------- 949
Query: 373 NTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLM 432
GSP +S TSS P P + S + + P+ P+ + +L+
Sbjct: 950 -----PDKSGSPGK-KTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPE--PKRPSVDSLV 1001
Query: 433 SSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGL 468
S TP S + P P+ P +P KL+ G+
Sbjct: 1002 SKF--TPPAESGSPSKETLPPPAAPPKPGKLNLSGV 1035
Score = 31.6 bits (70), Expect = 2.9
Identities = 70/316 (22%), Positives = 105/316 (33%), Gaps = 62/316 (19%)
Query: 189 PSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTG 248
P P E L + P P+ P + +P P S + + + T
Sbjct: 918 PPPPESSL--VFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTP 975
Query: 249 MSLQIPSSSTGISY------SIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPP------- 295
SS+G + S+ S + P+ S + SK + + P A PP
Sbjct: 976 QRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSK---ETLPPPAAPPKPGKLNL 1032
Query: 296 ----LPVPQWHHAHQLKALAASKQGSATKQQGPTP-SWSGLPPPGLSPPYRPVPSPHPPP 350
LP KA S +G + + P+P S S PPP PP
Sbjct: 1033 SGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPP-------------PPE 1079
Query: 351 LPLPPPPPPF--------SPQSLMVSCMSSNTLSGSTLRGSP--------NALLSSMTSS 394
LP PP SP+ +V+ S + P + L+ S
Sbjct: 1080 TELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEIS 1139
Query: 395 SNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGP 454
+ +P P P +L+ QP F + + L +I T G L S + + P
Sbjct: 1140 EQPTMATVVPQVPTS-PKSSLSVQPGF--LADLNRTLQRKSI-TRHGSLSSRMSRAEPTA 1195
Query: 455 S------PPYRPEKLS 464
+ PP PE LS
Sbjct: 1196 TMDDMALPPPPPELLS 1211
>gi|221139926 NHS-like 1 [Homo sapiens]
Length = 1606
Score = 56.6 bits (135), Expect = 9e-08
Identities = 80/371 (21%), Positives = 124/371 (33%), Gaps = 89/371 (23%)
Query: 252 QIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPV------------- 298
Q+P S P S +++SPSS + Q+ P AL P+PV
Sbjct: 826 QVPGGSVKPKIMSPEKSHRVISPSSGYSS-----QSNTPTALTPVPVFLKSVSPANGKGK 880
Query: 299 --PQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPP 356
P+ + S S+T T + L P P+P PPP+P PP
Sbjct: 881 PKPKVPERKSSLISSVSISSSSTSLSSSTSTEGSGTMKKLDPAVGSPPAPPPPPVPSPPF 940
Query: 357 PPP------FSPQSLMVSCMSSNTLSGSTL--RGSPNALLSSMT------SSSNAALGPA 402
P P P + C + L S + P AL+ + S AL P
Sbjct: 941 PCPADRSPFLPPPPPVTDCSQGSPLPHSPVFPPPPPEALIPFCSPPDWCLSPPRPALSPI 1000
Query: 403 MPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPE- 461
+P +P LP P LP+S P P+PP P+
Sbjct: 1001 LPDSPVSLPLPP------------------------------PLLPSSEPPPAPPLDPKF 1030
Query: 462 ------KLSSPGLPQQ---SFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISS 512
++ G P+ S P + + P L++ + Q Q +P+
Sbjct: 1031 MKDTRPPFTNSGQPESSRGSLRPPSTKEETSRPPMPLITTEALQMVQ-------LRPVRK 1083
Query: 513 NSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHY 572
NS + + ++ + + KP + S +M S + S L
Sbjct: 1084 NSGAEAAQLSERTAQEQRTPVAPQY---HLKPSAFLKSRNSTNEMESESQPASVTSSL-- 1138
Query: 573 LQQPTPTQASS 583
PTP ++SS
Sbjct: 1139 ---PTPAKSSS 1146
Score = 33.1 bits (74), Expect = 1.0
Identities = 38/170 (22%), Positives = 64/170 (37%), Gaps = 18/170 (10%)
Query: 203 KPEEPLVLDHPQATLSTTPKPSVQMSHLESLAS------SKEFASSCSQVTGMSLQIPSS 256
+PE P +T T +P + + E+L K + +Q++ + Q +
Sbjct: 1043 QPESSRGSLRPPSTKEETSRPPMPLITTEALQMVQLRPVRKNSGAEAAQLSERTAQEQRT 1102
Query: 257 STGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQG 316
Y + ++ S++ +S+SQ ++ LP P + AA + G
Sbjct: 1103 PVAPQYHLKPSAFLKSRNSTNEMESESQPASVTS----SLPTPAKSSSQGDHGSAAERGG 1158
Query: 317 SATKQQGPT--------PSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPP 358
++ G PS S P P SP +P P P L L PPP
Sbjct: 1159 PVSRSPGAPSAGEAEARPSPSTTPLPDSSPSRKPPPISKKPKLFLVVPPP 1208
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 56.6 bits (135), Expect = 9e-08
Identities = 109/443 (24%), Positives = 151/443 (34%), Gaps = 73/443 (16%)
Query: 315 QGSATKQQGP-----TPSWSGLPPPGLSPPY---------RPVPSPHPPPLPLPPPPPPF 360
+G +T Q GP TP P + P +P P P P L L PP
Sbjct: 4039 EGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLP 4098
Query: 361 SPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQ 420
Q VS + T G + L S +SS +++ P L P+++ Q
Sbjct: 4099 GQQQQQVSLL-------HTAGGGSHGQLGSGSSSEASSV-------PHLLAQPSVSLGDQ 4144
Query: 421 FGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPY-RPEKLSSPGLPQQSFTPQCSL 479
G S+ NL+ PQ ++ +N GP PP P S GLP P
Sbjct: 4145 PG---SMTQNLLG-----PQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQ 4196
Query: 480 IR-------SLTPTSNLLSQQQQQ---------QQQQQQANVIFKPISSNSSKTLSMIMQ 523
+R + P LS QQQQ Q QQ QA P ++T +
Sbjct: 4197 LRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPL--- 4253
Query: 524 QGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYL--QQPTPTQA 581
QG+ P F T PL + P PQ P +P S L PTP +
Sbjct: 4254 QGLLGCQP-QLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPS 4312
Query: 582 SSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQ--MMQQPQRFQRSVASDSMPALPRQ 639
S + Q + Q P H Q ++ P A+ L +
Sbjct: 4313 SPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSK 4372
Query: 640 GCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQPGDVSPSNITHVDKACKLG---EARHPQ 696
G L W + + Q +S PG + N V +A +L E R
Sbjct: 4373 G---LGPWDPPDNLAETQKPEQSSLV------PGHLDQVNGQVVPEASQLSIKQEPREEP 4423
Query: 697 VSLGRQPPSCQALGSESFLPGSS 719
+LG Q +A G PG+S
Sbjct: 4424 CALGAQSVKREANGEPIGAPGTS 4446
Score = 53.5 bits (127), Expect = 7e-07
Identities = 70/255 (27%), Positives = 92/255 (36%), Gaps = 54/255 (21%)
Query: 395 SNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHL----MSALPAS 450
+N ALGP P+ L P+ Q ++ L + PQG L ++ L
Sbjct: 3765 TNQALGPK----PQGLMPPS-------SHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQ 3813
Query: 451 NPGPSPPYRPEK---------LSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQ 501
+PG P P + LSSP L QQ + L + +QQQQQQQQ Q
Sbjct: 3814 HPGALGPQGPHRQVLMTQSRVLSSPQLAQQG--------QGLMGHRLVTAQQQQQQQQHQ 3865
Query: 502 QANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMP 561
Q S LS + Q M+ S G+ + L Q++
Sbjct: 3866 Q---------QGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQ------QQQL---- 3906
Query: 562 TTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQP 621
+Q L QQ Q Q Q QQQQQQQ L QQ QQ
Sbjct: 3907 ---QQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQ 3963
Query: 622 QRFQRSVASDSMPAL 636
Q+FQ+ M L
Sbjct: 3964 QQFQQQQQQQQMGLL 3978
Score = 49.7 bits (117), Expect = 1e-05
Identities = 77/269 (28%), Positives = 95/269 (35%), Gaps = 51/269 (18%)
Query: 394 SSNAALGPAM-PYAPEKLPS---PALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPA 449
S+ AL P+ P KLP P QP GP L TP G ALP
Sbjct: 3614 SAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLRL----TPGG---MALPG 3666
Query: 450 SNPGP----SPPYRPEKLSSPGL-----PQQSFTPQCSLIRSLTPTSNLLSQ-------- 492
GP + + ++ S G P F P +RSL P S LL +
Sbjct: 3667 QPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQLQLQQQ 3726
Query: 493 --------QQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKP 544
QQQQQQQQQQ +++ + QQG + A P G P
Sbjct: 3727 RMQLAQKLQQQQQQQQQQQHLL-------GQVAIQQQQQQGPGVQTNQALGPKPQGLMPP 3779
Query: 545 LSH---FVSEPGPQKMPSMPTTSRQPSLLHYLQQPTP----TQASSATASSTATATLQLQ 597
SH V + PQ P P P+ + LQQ P Q T + L
Sbjct: 3780 SSHQGLLVQQLSPQP-PQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSP 3838
Query: 598 QQQQQQQQQPDHSSFLLQQMMQQPQRFQR 626
Q QQ Q H QQ QQ Q Q+
Sbjct: 3839 QLAQQGQGLMGHRLVTAQQQQQQQQHQQQ 3867
Score = 48.5 bits (114), Expect = 2e-05
Identities = 115/505 (22%), Positives = 164/505 (32%), Gaps = 57/505 (11%)
Query: 101 PSTACAELQVPP--LTINPSPAAMGVAGQSLLLENNPMNGNIMGSPFVVPQTTEVGLKGP 158
P + L PP L +P P A+ + S LE +P++ SP P + P
Sbjct: 460 PPPEASRLSPPPEELPASPLPEALHL---SRPLEESPLSPPPEESPLSPPPESS-----P 511
Query: 159 TVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLS 218
P E S P L L+ + SP E+ + P E L P
Sbjct: 512 FSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASR 571
Query: 219 TTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSM 278
+P P ES S S S S P P S P +S
Sbjct: 572 LSPPPE------ESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASR 625
Query: 279 AQSKSQVQAMLPVA--LPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGL 336
+ M P P P P+ L ++ + P P S L PP
Sbjct: 626 LSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVS---------RLSPPPEESPLSPPPE 676
Query: 337 SPPYRPVP-----SPHPPPLPLPPPP--PPFSP---QSLMVSCMSSNTL-----SGSTLR 381
P P P SP P P PPP P SP SLM + + L
Sbjct: 677 ESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCP 736
Query: 382 GSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQ-----FGPQSSILANLMSSTI 436
S LS + + P P+ + P L+ QP+ P+ L+
Sbjct: 737 RSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPH 796
Query: 437 KTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCS--LIRSLTPTSNLLSQQQ 494
+PQ + P + P E SP + +PQ + S+L + +
Sbjct: 797 LSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELE 856
Query: 495 QQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEP-FTFGNTKPLSHFVSEPG 553
+ + +P + + L + G S SP EP + PLS P
Sbjct: 857 KPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLS-----PL 911
Query: 554 PQKMPSMPTTSRQPSLLHYLQQPTP 578
P+++P P S +PSL L P P
Sbjct: 912 PEELPLSP--SGEPSLSPQLMPPDP 934
Score = 44.7 bits (104), Expect = 3e-04
Identities = 136/571 (23%), Positives = 210/571 (36%), Gaps = 94/571 (16%)
Query: 90 DVTLAMGPGAHPSTACAELQVP---PLTINPSPAA------MGVAGQSLLLENNPMNGNI 140
+V +GPG P Q P P++ +P A + V+G + P +
Sbjct: 2883 NVQKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAPEL 2942
Query: 141 MGSPFVVPQTTEVGLKGPTVPYYEKINSVPAVDQEL---QELLEELTKI--QDPS-PNEL 194
S P T KGPT+P ++ + P EL L E K+ +DP ++
Sbjct: 2943 NNSLHPTPHT-----KGPTLPTGLELVNRPPSSTELGRPNPLALEAGKLPCEDPELDDDF 2997
Query: 195 DLEKILGTKPEEP---LVLDHPQAT--LSTTPKPSVQMSHLESLASSKEFASSCSQVTGM 249
D K L E L +D + L T HL+ L + EF +
Sbjct: 2998 DAHKALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDL-------L 3050
Query: 250 SLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKA 309
+ P TG I + ++V ++ A+ ++ ++ + P L P P A
Sbjct: 3051 AYTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGVEPGPLGPEERPP-------PA 3103
Query: 310 LAASKQ--GSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMV 367
AS+ S + P G P SP + +P P P + SL +
Sbjct: 3104 ADASEPRLASVLPEVKPKVEEGGRHP---SPCQFTIATPKVEPAP--------AANSLGL 3152
Query: 368 SCMSSNTLSGST-LRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSS 426
++ GS R SS ++ A+ G A P+ LT P GP S
Sbjct: 3153 GLKPGQSMMGSRDTRMGTGPFSSSGHTAEKASFG-----ATGGPPAHLLTPSPLSGPGGS 3207
Query: 427 ILAN---LMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSS--PGLPQQSFTPQCSLIR 481
L L S + P G PA++ ++S P L + + ++
Sbjct: 3208 SLLEKFELESGALTLPGG------PAASGDELDKMESSLVASELPLLIEDLLEHEKKELQ 3261
Query: 482 SLTPTSNLLSQQQQQQQQQQQANVIFKP--------ISSNSSKTLSMIMQQ---GMASS- 529
S L QQQQQQQQQ +++ P SS +L+ QQ G+A +
Sbjct: 3262 KKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLAGSQQQLSLGLAGAR 3321
Query: 530 SPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLL---HYLQQPTPTQASSATA 586
PG +P T+P +H + + + PSM S Q +L H Q Q SS
Sbjct: 3322 QPGLPQPLM--PTQPPAHALQQ---RLAPSMAMVSNQGHMLSGQHGGQAGLVPQQSSQPV 3376
Query: 587 SS-----TATATLQLQQQQQQQQQQPDHSSF 612
S T ++ ++ QQ QQQ +S F
Sbjct: 3377 LSQKPMGTMPPSMCMKPQQLAMQQQLANSFF 3407
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/248 (25%), Positives = 94/248 (37%), Gaps = 43/248 (17%)
Query: 492 QQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQ---GMASSSPGATEPFTFGNTKPLSHF 548
QQQQQQQQQQQ + + S S + L+ + Q G P G +
Sbjct: 3602 QQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLR----- 3656
Query: 549 VSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATAS-------------STATATLQ 595
PG +P P + L QQ + + + A S +
Sbjct: 3657 -LTPGGMALPGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRSLGPDSRL 3715
Query: 596 LQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVK 655
LQ++Q Q QQQ + LQQ QQ Q+ Q + ++ +QG T+ A K
Sbjct: 3716 LQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQG---PGVQTNQALGPK 3772
Query: 656 PQ-----HQHGNSFTSRQDPQP-----GDVSPSNITHVDKACKLGEARHPQVSLGRQPPS 705
PQ H + PQP G + P+ + + + +HP +LG Q P
Sbjct: 3773 PQGLMPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVL-------QQQHPG-ALGPQGPH 3824
Query: 706 CQALGSES 713
Q L ++S
Sbjct: 3825 RQVLMTQS 3832
Score = 43.5 bits (101), Expect = 7e-04
Identities = 166/738 (22%), Positives = 247/738 (33%), Gaps = 160/738 (21%)
Query: 82 KIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLLEN---NPMNG 138
K + P L+++ + PG A L PP S A+ V + L + P N
Sbjct: 2246 KPRCPSLDNLAVPESPGVGGGKASEPLLSPP-PFGESRKALEVKKEELGASSPSYGPPNL 2304
Query: 139 NIMGSPFVVPQTTEVGLKGPTVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELDLEK 198
+ SP + LK P V K P Q + + Q+P P +
Sbjct: 2305 GFVDSPSSGTHLGGLELKTPDV---FKAPLTPRASQVEPQSPGLGLRPQEPPP----AQA 2357
Query: 199 ILGTKPEEPLVL-----DHPQATLSTTPKP---------SVQMSHLESLASSKEFASSCS 244
+ + P P + P A TP+P ++ L S S+ AS S
Sbjct: 2358 LAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQS 2417
Query: 245 QVTGMSLQIPSSSTGISYSIPSTSKQIVSPSS-SMAQSKSQVQ-AMLPVALPPLPVPQWH 302
Q + S P + ++ + + SP S S+ Q + P+ PP P P
Sbjct: 2418 QSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPP-E 2476
Query: 303 HAHQLKALAASKQGS----ATKQQGPTPSWSGLPPPGLSPPYRPVP-------SPHP--- 348
A + +LA + G+ A GP P G P + P +P P
Sbjct: 2477 VAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRF 2536
Query: 349 ------------PPLPLPPPPPP------FSPQSLMVSCMSSN-TLSGSTLRGSPNAL-L 388
PP+P P PPP F P + S+N T++ S + L
Sbjct: 2537 TFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGP 2596
Query: 389 SSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHL--MSA 446
SS ++ + L P P P LP PA P G L +S
Sbjct: 2597 SSGSTGESYGLSPLRP--PSVLPPPA------------------------PDGSLPYLSH 2630
Query: 447 LPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQ---QQQQQQQQQQA 503
+ G + P EK PG S L + P + LSQ ++Q+Q+Q+ +
Sbjct: 2631 GASQRSGITSPV--EKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLRE 2688
Query: 504 NVIFKPISSNSSKTLSMIMQQGMASSSPGATEP--------------------FTFGNTK 543
+I + I N+ + ++ A+++ GA P F T+
Sbjct: 2689 LLIRQQIQRNTLR-----QEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQ 2743
Query: 544 PLSHFVSEP---------GPQKMPSMPTTSRQPSL-------LHYLQQPTPTQASSATAS 587
S V P GP PS SR P ++ Q +QA A
Sbjct: 2744 DKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAP 2803
Query: 588 STATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAW 647
+ LQ QQQQ QQQQ ++ + RF S S P P G L +
Sbjct: 2804 YPGSLPLQQQQQQLWQQQQATAATSM---------RFAMSARFPSTPG-PELGRQALGSP 2853
Query: 648 TSAASSVKPQHQHGNSFTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQ 707
+ S+ P +P PG P+ + + G G+ PP
Sbjct: 2854 LAGISTRLP---------GPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQ-- 2902
Query: 708 ALGSESFLPGSSFAHELA 725
F P S H LA
Sbjct: 2903 ---RPRFYPVSEDPHRLA 2917
Score = 42.0 bits (97), Expect = 0.002
Identities = 47/150 (31%), Positives = 62/150 (41%), Gaps = 10/150 (6%)
Query: 331 LPPPG---LSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMS-SNTLSGSTLRGSP-N 385
LPPP LSPP P+ PP PPP P S + + S L S L P
Sbjct: 441 LPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEE 500
Query: 386 ALLSSMTSSSNAALGPAMPYAP--EKLPSPALTQQPQFGPQSSILA-NLMSSTIKTPQGH 442
+ LS SS + P +P E PSPAL P++S L+ S + P
Sbjct: 501 SPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEE 560
Query: 443 LMSALPASNPGPSPPYRPEKLSSPGLPQQS 472
L ++ P SPP +S P P++S
Sbjct: 561 LPTSPPPEASRLSPPPEESPMSPP--PEES 588
Score = 38.5 bits (88), Expect = 0.024
Identities = 118/517 (22%), Positives = 185/517 (35%), Gaps = 71/517 (13%)
Query: 54 RKHQGTVKRRQEEDHFQFPDMADGGYPNKIKRPCL-----EDVTLAMGPGAHPSTACAEL 108
R + + R EE H P + + + PCL E G H S EL
Sbjct: 746 RPEEPHLSPRPEEPHLS-PQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEEL 804
Query: 109 QVPPLTINPSPAAMGVAGQSLLLENNPMNGNIMGS---PFVVPQTTEVGL-----KGPTV 160
+ P T P + + L P ++ P + P+ E L K P
Sbjct: 805 HLSPQTEEPH---LSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLS 861
Query: 161 PYYEKINSVPAVDQELQELLEELTKIQDPSPNELDLEKILG----TKPEEPLVLDHPQAT 216
P EK P +EL P P E L +LG ++P EP + P+
Sbjct: 862 PRPEKPPEEPGQCPAPEELP------LFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEEL 915
Query: 217 -LSTTPKPSV--QMSHLESLASSKEFASSCSQVTGMS----LQIPSSSTGISY-SIPSTS 268
LS + +PS+ Q+ + L + + +S L+ P + G S P +
Sbjct: 916 PLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAA 975
Query: 269 KQIVSPSSSMAQSK-SQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATK--QQGPT 325
+ +P S ++ + + + P+ LPP P S G A+ +
Sbjct: 976 PILETPISPPPEANCTDPEPVPPMILPPSP--------------GSPVGPASPILMEPLP 1021
Query: 326 PSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTL----SGSTLR 381
P S L L P P PP LPL P P SP +V L +
Sbjct: 1022 PQCSPLLQHSLVPQNSPPSQCSPPALPL-SVPSPLSPIGKVVGVSDEAELHEMETEKVSE 1080
Query: 382 GSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQG 441
AL S TS + +G AP P+PAL G ++ L + + + G
Sbjct: 1081 PECPALEPSATSPLPSPMGDLSCPAPS--PAPALDDFSGLGEDTAPLDGIDAPGSQPEPG 1138
Query: 442 HLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQ 501
+L + G PE+L +P P + + P+C ++Q++
Sbjct: 1139 QTPGSLASELKGSPVLLDPEEL-APVTPMEVY-PECKQTAG--------QGSPCEEQEEP 1188
Query: 502 QANVIFKPISSNSSKTLSMI--MQQGMASSSPGATEP 536
+A V P + S ++ I + QG AS+S +EP
Sbjct: 1189 RAPVAPTPPTLIKSDIVNEISNLSQGDASASFPGSEP 1225
Score = 38.5 bits (88), Expect = 0.024
Identities = 122/559 (21%), Positives = 189/559 (33%), Gaps = 92/559 (16%)
Query: 98 GAHPSTACAELQVPPLTINPSPAAMGVA---GQSLLLENNPMNGNIMGSPFVVP-QTTEV 153
G HPS + P + P+ ++G+ GQS++ + G PF T E
Sbjct: 3126 GRHPSPCQFTIATPKVEPAPAANSLGLGLKPGQSMMGSRDTRMGT---GPFSSSGHTAEK 3182
Query: 154 GLKGPTV-PYYEKINSVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLV--- 209
G T P + P LLE+ +LE T P P
Sbjct: 3183 ASFGATGGPPAHLLTPSPLSGPGGSSLLEKF-----------ELESGALTLPGGPAASGD 3231
Query: 210 -LDHPQATLSTTPKPSV---QMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIP 265
LD +++L + P + + H + K+ S+ Q Q + +S P
Sbjct: 3232 ELDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGP 3291
Query: 266 STSKQIVSPSSSMAQSKSQVQAMLPVA------LPPLPVPQWHHAHQLKALAASKQGSAT 319
+ + + SS + + SQ Q L +A LP +P AH L+ A +
Sbjct: 3292 AQAMSLPHEGSSPSLAGSQQQLSLGLAGARQPGLPQPLMPTQPPAHALQQRLAPSMAMVS 3351
Query: 320 KQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGST 379
Q G S GL P P P+ PP PQ L + +N+ T
Sbjct: 3352 NQ-GHMLSGQHGGQAGLVPQQSSQPVLSQKPMGTMPPSMCMKPQQLAMQQQLANSFFPDT 3410
Query: 380 --------------LRGSPNAL--LSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGP 423
+ AL + + + + + P M L L Q+ GP
Sbjct: 3411 DLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSL----LAQRLSGGP 3466
Query: 424 QSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSL 483
S + ++ + + G SA S P P+PP + + + +Q L
Sbjct: 3467 SSDLQNHVAAGS-----GQERSAGDPSQPRPNPPTFAQGVINEADQRQ-------YEEWL 3514
Query: 484 TPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTK 543
T LL Q Q V+ + I + ++ +Q A + G
Sbjct: 3515 FHTQQLL---------QMQLKVLEEQIGVHRKSRKALCAKQRTAKKA---------GREF 3556
Query: 544 PLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQ 603
P E +K+ + T +Q + L Q Q T Q QQQQQQQ
Sbjct: 3557 P------EADAEKLKLV--TEQQSKIQKQLDQ-VRKQQKEHTNLMAEYRNKQQQQQQQQQ 3607
Query: 604 QQQPDHSSFLLQQMMQQPQ 622
QQQ HS+ L Q P+
Sbjct: 3608 QQQQQHSAVLALSPSQSPR 3626
Score = 37.7 bits (86), Expect = 0.041
Identities = 61/236 (25%), Positives = 87/236 (36%), Gaps = 36/236 (15%)
Query: 334 PGLSPPYRPVPSPHPPPLPLPPPP------PPFSPQSLMVSCMSSNTLSGSTLRGSPNAL 387
P L PP SP P P PPP PP P+ L S + L SP
Sbjct: 439 PLLPPPEESPLSPPPEESPTSPPPEASRLSPP--PEELPASPLPEALHLSRPLEESP--- 493
Query: 388 LSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSAL 447
LS S P P PE P L + P P+ S S ++TP +S
Sbjct: 494 LSPPPEES-----PLSP-PPESSPFSPLEESPLSPPEES----PPSPALETP----LSPP 539
Query: 448 PASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLS--QQQQQQQQQQQANV 505
P ++P SPP+ LS P + P + S P + +S ++ +A+
Sbjct: 540 PEASP-LSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASR 598
Query: 506 IFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMP 561
+F P + LS ++ S P A+ P+S P P++ P P
Sbjct: 599 LFPPFEES---PLSPPPEESPLSPPPEASRLSPPPEDSPMS-----PPPEESPMSP 646
Score = 36.6 bits (83), Expect = 0.091
Identities = 66/286 (23%), Positives = 105/286 (36%), Gaps = 48/286 (16%)
Query: 93 LAMGPGAHPSTACAELQVPPLTINPSPAAM--GVAGQSLLLENNPMNGNIMGSPFVVPQT 150
L G + S+ L P +++ P +M + G + PM N P P+
Sbjct: 4119 LGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQP---PKP 4175
Query: 151 TEVGLKGPTVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVL 210
V G +P + +V + +LQ +L + +++ SP + + L + + L
Sbjct: 4176 GPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQ----L 4231
Query: 211 DHPQATLSTTP--KPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSI---- 264
QA T P +P Q S L+ L + Q+ G P TG +
Sbjct: 4232 QQSQAVRQTPPYQEPGTQTSPLQGLLGCQP------QLGGF----PGPQTGPLQELGAGP 4281
Query: 265 -PSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQG 323
P ++ +P +++ PV P P P +S Q Q
Sbjct: 4282 RPQGPPRLPAPPGALSTG--------PVLGPVHPTPP----------PSSPQEPKRPSQL 4323
Query: 324 PTPSWSGLPPPGLSPPYRP-VPSPHPPPLPLPPPPPPFSPQSLMVS 368
P+PS S LP PP P P P P L PPP SP + ++
Sbjct: 4324 PSPS-SQLPTEAQLPPTHPGTPKPQGP--TLEPPPGRVSPAAAQLA 4366
Score = 36.2 bits (82), Expect = 0.12
Identities = 25/75 (33%), Positives = 32/75 (42%), Gaps = 5/75 (6%)
Query: 295 PLPVPQWHHAHQLKALAAS-KQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPL 353
P P P H++ +Q SA + P+P S L P SPP P+ PL
Sbjct: 4884 PAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAE 4943
Query: 354 PPPPPPF----SPQS 364
PP P P SP+S
Sbjct: 4944 PPVPSPLPLASSPES 4958
Score = 31.6 bits (70), Expect = 2.9
Identities = 52/203 (25%), Positives = 66/203 (32%), Gaps = 49/203 (24%)
Query: 330 GLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGS----------- 378
GLPP LS P P P L PPPP +P S+ V+ S + GS
Sbjct: 2750 GLPPSKLSGPILG-PGSFPSDDRLSRPPPPATPSSMDVN--SRQLVGGSQAFYQRAPYPG 2806
Query: 379 --TLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANL--MSS 434
L+ L +++ ++ AM P P L +Q P + I L
Sbjct: 2807 SLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQALGSPLAGISTRLPGPGE 2866
Query: 435 TIKTPQGHLMSALPASN------------PGPSPPYRP-----------------EKLSS 465
+ P G N PG PP RP L+
Sbjct: 2867 PVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAV 2926
Query: 466 PGLPQQ--SFTPQCSLIRSLTPT 486
GLP Q S P L SL PT
Sbjct: 2927 SGLPPQKPSAPPAPELNNSLHPT 2949
>gi|50345997 E1A binding protein p300 [Homo sapiens]
Length = 2414
Score = 56.2 bits (134), Expect = 1e-07
Identities = 106/461 (22%), Positives = 152/461 (32%), Gaps = 92/461 (19%)
Query: 304 AHQLKALAASKQ--GSATKQQG---PTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPP-PP 357
A L+ AS Q G +QQG PTP+ + P G P P P P P PP
Sbjct: 1825 AQMLRRRMASMQRTGVVGQQQGLPSPTPA-TPTTPTGQQPTTPQTPQPTSQPQPTPPNSM 1883
Query: 358 PPFSPQSLMVSCMSSNTLSGST------------LRGSPNALLSSMTSSSNAALGPAMPY 405
PP+ P++ +S +G L G P A + AA
Sbjct: 1884 PPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMA 1943
Query: 406 APEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPY------R 459
+ P Q P P + + N T + P GHL + + PP+ +
Sbjct: 1944 HVQIFQRPIQHQMPPMTPMAPMGMNPPPMT-RGPSGHLEPGMGPTGMQQQPPWSQGGLPQ 2002
Query: 460 PEKLSS----------------------PGLPQQSFTP----------QCSLIRSLTPTS 487
P++L S PGL Q +P +L+R+L S
Sbjct: 2003 PQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPS 2062
Query: 488 NLLSQQQQQQQQQQQANVIFKPISSNSSKTLS-----MIMQQGMASSSPGATEPFTFG-- 540
+ L QQQ ++ I ++K + + Q GM PG P G
Sbjct: 2063 SPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQ 2122
Query: 541 ---------NTKPLSHFVSEPG-PQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTA 590
N P+ V G PQ+ P QP + Q + T S
Sbjct: 2123 GVHSNPAMQNMNPMQAGVQRAGLPQQQPQQ---QLQPPMGGMSPQAQQMNMNHNTMPSQF 2179
Query: 591 TATLQLQQQQQQQQQQ----------PDHSSFLLQQMM----QQPQRFQRSVASDSMPAL 636
L+ QQ QQQQQQ +H+ F Q + QQ QR Q + +
Sbjct: 2180 RDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNM 2239
Query: 637 PRQGCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQPGDVSP 677
+ G A +S++ Q QP +SP
Sbjct: 2240 GQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSP 2280
Score = 48.5 bits (114), Expect = 2e-05
Identities = 79/339 (23%), Positives = 116/339 (34%), Gaps = 67/339 (19%)
Query: 252 QIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALA 311
Q PS ++ +IP +P S S S P+ +PP H QL
Sbjct: 769 QFPSQGMNVT-NIPLAPSSGQAPVSQAQMSSSSCPVNSPI-MPPGSQGSHIHCPQLPQ-- 824
Query: 312 ASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMS 371
A Q P+P S P P +PP P +P P P PP P
Sbjct: 825 -----PALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPG------- 872
Query: 372 SNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANL 431
L P + T+ + P++P AP QPQ P+S
Sbjct: 873 ---PQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPS-------ADQPQQQPRSQ---QS 919
Query: 432 MSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLS 491
++++ TP L+ P P+ P +S G Q S P S S S ++
Sbjct: 920 TAASVPTPTAPLLP------PQPATPLSQPAVSIEG--QVSNPPSTS---STEVNSQAIA 968
Query: 492 QQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSE 551
++Q Q+ + +A M P EP +T+P S+
Sbjct: 969 EKQPSQEVKMEAK---------------------MEVDQP---EP---ADTQPEDISESK 1001
Query: 552 PGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTA 590
KM S T R L +++ ++SAT SS A
Sbjct: 1002 VEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPA 1040
Score = 38.1 bits (87), Expect = 0.031
Identities = 38/157 (24%), Positives = 62/157 (39%), Gaps = 20/157 (12%)
Query: 492 QQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMAS------SSPGATEPFTFGNTKPL 545
+QQQ Q + QQA ++ + ++S +T + QQG+ S ++P +P T +P
Sbjct: 1814 RQQQLQHRLQQAQMLRRRMAS-MQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPT 1872
Query: 546 SHFVSEPGPQKMPSMPTTS-----RQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQ 600
S P P +P T Q + PTP Q + A +++ Q
Sbjct: 1873 SQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQI 1932
Query: 601 QQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALP 637
Q+ + Q+ M Q FQR + P P
Sbjct: 1933 QRAAE--------TQRQMAHVQIFQRPIQHQMPPMTP 1961
Score = 37.0 bits (84), Expect = 0.070
Identities = 76/305 (24%), Positives = 106/305 (34%), Gaps = 57/305 (18%)
Query: 350 PLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGS-PNALLSSMTSSSNAALGPAMPYAPE 408
P+ + P P PQ M S + S +RGS PN ++ +T S
Sbjct: 666 PVSMNPGPNMGQPQPGMTS--NGPLPDPSMIRGSVPNQMMPRITPQSGLN---------- 713
Query: 409 KLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALP-ASNPGPSPPYRPEKLSSPG 467
QFG S ++ Q H A P A NP R ++ S+ G
Sbjct: 714 -----------QFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQG 762
Query: 468 --LPQQSFTPQCSLIRS--LTPTSNL--LSQQQQQQQQQQQANVIFKPISSNSSKTLSMI 521
LPQ F Q + + L P+S +SQ Q + I P S S +
Sbjct: 763 QFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQL 822
Query: 522 MQQGMASSSPGATE---------PFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHY 572
Q + +SP P + G +P + + P P P+MP Q LH
Sbjct: 823 PQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTP-PAMPP-GPQSQALHP 880
Query: 573 LQQPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDS 632
+ TPT ++ Q QQ Q P S Q QQP+ Q + AS
Sbjct: 881 PPRQTPTPPTT-------------QLPQQVQPSLPAAPS--ADQPQQQPRSQQSTAASVP 925
Query: 633 MPALP 637
P P
Sbjct: 926 TPTAP 930
Score = 33.5 bits (75), Expect = 0.77
Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 5/129 (3%)
Query: 275 SSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQG----SATKQQGPTPSWSG 330
+S A + +Q + + P P+ H +A + QG ++ Q +P
Sbjct: 2255 ASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVP 2314
Query: 331 LPPPGLSPPYR-PVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLS 389
P P PP+ P P P P P P SP +V+ ++ G N++LS
Sbjct: 2315 SPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLS 2374
Query: 390 SMTSSSNAA 398
+ S+ A
Sbjct: 2375 QLASNPGMA 2383
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,266,062
Number of Sequences: 37866
Number of extensions: 2396878
Number of successful extensions: 41329
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 577
Number of HSP's successfully gapped in prelim test: 1322
Number of HSP's that attempted gapping in prelim test: 15389
Number of HSP's gapped (non-prelim): 11068
length of query: 774
length of database: 18,247,518
effective HSP length: 110
effective length of query: 664
effective length of database: 14,082,258
effective search space: 9350619312
effective search space used: 9350619312
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.