Guide to the Human Genome
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Search of human proteins with 113204615

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
         (5038 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ...  1.018e+04   0.0  
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ...  1.017e+04   0.0  
gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]        6623   0.0  
gi|126032338 ryanodine receptor 3 [Homo sapiens]                     4771   0.0  
gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo s...   167   2e-40
gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isofor...   166   7e-40
gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isofor...   166   7e-40
gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo ...   161   2e-38
gi|17975763 myelin transcription factor 1 [Homo sapiens]               78   2e-13
gi|37588869 ring finger protein 123 [Homo sapiens]                     71   3e-11
gi|45387949 ring finger and SPRY domain containing 1 [Homo sapiens]    69   2e-10
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    67   4e-10
gi|58761548 tau tubulin kinase 1 [Homo sapiens]                        67   4e-10
gi|169210053 PREDICTED: hypothetical protein [Homo sapiens]            66   8e-10
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]              62   1e-08
gi|148839339 nexilin (F actin binding protein) [Homo sapiens]          62   1e-08
gi|189409130 zinc finger E-box binding homeobox 1 isoform a [Hom...    60   4e-08
gi|189409128 zinc finger E-box binding homeobox 1 isoform b [Hom...    60   4e-08
gi|22749303 hypothetical protein LOC196477 [Homo sapiens]              60   4e-08
gi|221219020 NYD-SP11 protein [Homo sapiens]                           60   7e-08
gi|4508005 tripartite motif-containing 26 [Homo sapiens]               59   9e-08
gi|21735569 claspin [Homo sapiens]                                     59   2e-07
gi|148746195 trichohyalin [Homo sapiens]                               59   2e-07
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)...    58   2e-07
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]           58   2e-07
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]           58   2e-07
gi|60498973 myelin transcription factor 1-like [Homo sapiens]          58   3e-07
gi|21735415 centromere protein B [Homo sapiens]                        57   4e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    57   4e-07
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    57   4e-07

>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
            sapiens]
          Length = 5038

 Score = 1.018e+04 bits (26426), Expect = 0.0
 Identities = 5038/5038 (100%), Positives = 5038/5038 (100%)

Query: 1    MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD 60
            MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
Sbjct: 1    MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD 60

Query: 61   LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120
            LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL
Sbjct: 61   LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120

Query: 121  TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180
            TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH
Sbjct: 121  TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180

Query: 181  LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ 240
            LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ
Sbjct: 181  LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ 240

Query: 241  RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV 300
            RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV
Sbjct: 241  RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV 300

Query: 301  VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA 360
            VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA
Sbjct: 301  VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA 360

Query: 361  PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420
            PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF
Sbjct: 361  PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420

Query: 421  SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480
            SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE
Sbjct: 421  SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480

Query: 481  GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS 540
            GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS
Sbjct: 481  GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS 540

Query: 541  TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD 600
            TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD
Sbjct: 541  TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD 600

Query: 601  VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK 660
            VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK
Sbjct: 601  VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK 660

Query: 661  WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL 720
            WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL
Sbjct: 661  WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL 720

Query: 721  WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV 780
            WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV
Sbjct: 721  WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV 780

Query: 781  SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG 840
            SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG
Sbjct: 781  SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG 840

Query: 841  PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK 900
            PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK
Sbjct: 841  PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK 900

Query: 901  RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM 960
            RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM
Sbjct: 901  RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM 960

Query: 961  SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL 1020
            SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL
Sbjct: 961  SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL 1020

Query: 1021 VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY 1080
            VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY
Sbjct: 1021 VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY 1080

Query: 1081 TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR 1140
            TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR
Sbjct: 1081 TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR 1140

Query: 1141 PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH 1200
            PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH
Sbjct: 1141 PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH 1200

Query: 1201 LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD 1260
            LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD
Sbjct: 1201 LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD 1260

Query: 1261 GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED 1320
            GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED
Sbjct: 1261 GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED 1320

Query: 1321 EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT 1380
            EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT
Sbjct: 1321 EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT 1380

Query: 1381 EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA 1440
            EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA
Sbjct: 1381 EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA 1440

Query: 1441 GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV 1500
            GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV
Sbjct: 1441 GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV 1500

Query: 1501 SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV 1560
            SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV
Sbjct: 1501 SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV 1560

Query: 1561 IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG 1620
            IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG
Sbjct: 1561 IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG 1620

Query: 1621 ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV 1680
            ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV
Sbjct: 1621 ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV 1680

Query: 1681 AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE 1740
            AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE
Sbjct: 1681 AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE 1740

Query: 1741 TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP 1800
            TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP
Sbjct: 1741 TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP 1800

Query: 1801 AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK 1860
            AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK
Sbjct: 1801 AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK 1860

Query: 1861 QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
            QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE
Sbjct: 1861 QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920

Query: 1921 GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL 1980
            GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL
Sbjct: 1921 GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL 1980

Query: 1981 IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA 2040
            IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA
Sbjct: 1981 IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA 2040

Query: 2041 HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH 2100
            HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH
Sbjct: 2041 HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH 2100

Query: 2101 MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG 2160
            MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG
Sbjct: 2101 MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG 2160

Query: 2161 QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES 2220
            QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES
Sbjct: 2161 QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES 2220

Query: 2221 KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV 2280
            KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV
Sbjct: 2221 KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV 2280

Query: 2281 IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF 2340
            IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF
Sbjct: 2281 IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF 2340

Query: 2341 VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD 2400
            VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD
Sbjct: 2341 VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD 2400

Query: 2401 RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL 2460
            RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL
Sbjct: 2401 RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL 2460

Query: 2461 VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH 2520
            VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH
Sbjct: 2461 VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH 2520

Query: 2521 VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD 2580
            VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD
Sbjct: 2521 VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD 2580

Query: 2581 SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP 2640
            SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP
Sbjct: 2581 SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP 2640

Query: 2641 LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM 2700
            LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM
Sbjct: 2641 LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM 2700

Query: 2701 PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE 2760
            PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE
Sbjct: 2701 PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE 2760

Query: 2761 YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE 2820
            YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE
Sbjct: 2761 YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE 2820

Query: 2821 WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE 2880
            WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE
Sbjct: 2821 WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE 2880

Query: 2881 NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG 2940
            NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG
Sbjct: 2881 NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG 2940

Query: 2941 LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK 3000
            LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK
Sbjct: 2941 LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK 3000

Query: 3001 ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD 3060
            ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD
Sbjct: 3001 ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD 3060

Query: 3061 APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART 3120
            APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART
Sbjct: 3061 APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART 3120

Query: 3121 QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN 3180
            QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN
Sbjct: 3121 QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN 3180

Query: 3181 TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC 3240
            TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC
Sbjct: 3181 TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC 3240

Query: 3241 PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA 3300
            PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA
Sbjct: 3241 PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA 3300

Query: 3301 PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP 3360
            PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP
Sbjct: 3301 PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP 3360

Query: 3361 TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR 3420
            TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR
Sbjct: 3361 TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR 3420

Query: 3421 AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK 3480
            AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK
Sbjct: 3421 AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK 3480

Query: 3481 AGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY 3540
            AGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY
Sbjct: 3481 AGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY 3540

Query: 3541 ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS 3600
            ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS
Sbjct: 3541 ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS 3600

Query: 3601 AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA 3660
            AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA
Sbjct: 3601 AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA 3660

Query: 3661 WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY 3720
            WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY
Sbjct: 3661 WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY 3720

Query: 3721 LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ 3780
            LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ
Sbjct: 3721 LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ 3780

Query: 3781 MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV 3840
            MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV
Sbjct: 3781 MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV 3840

Query: 3841 LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN 3900
            LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN
Sbjct: 3841 LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN 3900

Query: 3901 YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV 3960
            YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV
Sbjct: 3901 YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV 3960

Query: 3961 FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK 4020
            FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK
Sbjct: 3961 FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK 4020

Query: 4021 DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV 4080
            DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV
Sbjct: 4021 DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV 4080

Query: 4081 TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF 4140
            TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF
Sbjct: 4081 TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF 4140

Query: 4141 NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN 4200
            NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN
Sbjct: 4141 NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN 4200

Query: 4201 RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD 4260
            RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD
Sbjct: 4201 RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD 4260

Query: 4261 EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL 4320
            EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL
Sbjct: 4261 EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL 4320

Query: 4321 RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL 4380
            RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL
Sbjct: 4321 RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL 4380

Query: 4381 AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV 4440
            AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV
Sbjct: 4381 AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV 4440

Query: 4441 TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE 4500
            TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE
Sbjct: 4441 TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE 4500

Query: 4501 PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF 4560
            PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF
Sbjct: 4501 PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF 4560

Query: 4561 YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA 4620
            YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA
Sbjct: 4561 YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA 4620

Query: 4621 EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR 4680
            EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR
Sbjct: 4621 EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR 4680

Query: 4681 KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE 4740
            KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE
Sbjct: 4681 KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE 4740

Query: 4741 LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS 4800
            LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS
Sbjct: 4741 LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS 4800

Query: 4801 LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF 4860
            LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF
Sbjct: 4801 LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF 4860

Query: 4861 RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT 4920
            RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT
Sbjct: 4861 RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT 4920

Query: 4921 FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT 4980
            FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT
Sbjct: 4921 FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT 4980

Query: 4981 LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5038
            LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS
Sbjct: 4981 LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5038


>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
            sapiens]
          Length = 5033

 Score = 1.017e+04 bits (26385), Expect = 0.0
 Identities = 5033/5038 (99%), Positives = 5033/5038 (99%), Gaps = 5/5038 (0%)

Query: 1    MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD 60
            MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
Sbjct: 1    MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD 60

Query: 61   LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120
            LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL
Sbjct: 61   LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120

Query: 121  TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180
            TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH
Sbjct: 121  TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180

Query: 181  LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ 240
            LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ
Sbjct: 181  LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ 240

Query: 241  RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV 300
            RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV
Sbjct: 241  RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV 300

Query: 301  VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA 360
            VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA
Sbjct: 301  VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA 360

Query: 361  PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420
            PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF
Sbjct: 361  PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420

Query: 421  SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480
            SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE
Sbjct: 421  SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480

Query: 481  GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS 540
            GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS
Sbjct: 481  GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS 540

Query: 541  TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD 600
            TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD
Sbjct: 541  TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD 600

Query: 601  VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK 660
            VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK
Sbjct: 601  VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK 660

Query: 661  WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL 720
            WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL
Sbjct: 661  WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL 720

Query: 721  WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV 780
            WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV
Sbjct: 721  WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV 780

Query: 781  SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG 840
            SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG
Sbjct: 781  SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG 840

Query: 841  PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK 900
            PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK
Sbjct: 841  PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK 900

Query: 901  RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM 960
            RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM
Sbjct: 901  RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM 960

Query: 961  SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL 1020
            SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL
Sbjct: 961  SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL 1020

Query: 1021 VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY 1080
            VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY
Sbjct: 1021 VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY 1080

Query: 1081 TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR 1140
            TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR
Sbjct: 1081 TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR 1140

Query: 1141 PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH 1200
            PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH
Sbjct: 1141 PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH 1200

Query: 1201 LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD 1260
            LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD
Sbjct: 1201 LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD 1260

Query: 1261 GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED 1320
            GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED
Sbjct: 1261 GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED 1320

Query: 1321 EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT 1380
            EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT
Sbjct: 1321 EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT 1380

Query: 1381 EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA 1440
            EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA
Sbjct: 1381 EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA 1440

Query: 1441 GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV 1500
            GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV
Sbjct: 1441 GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV 1500

Query: 1501 SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV 1560
            SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV
Sbjct: 1501 SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV 1560

Query: 1561 IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG 1620
            IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG
Sbjct: 1561 IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG 1620

Query: 1621 ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV 1680
            ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV
Sbjct: 1621 ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV 1680

Query: 1681 AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE 1740
            AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE
Sbjct: 1681 AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE 1740

Query: 1741 TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP 1800
            TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP
Sbjct: 1741 TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP 1800

Query: 1801 AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK 1860
            AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK
Sbjct: 1801 AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK 1860

Query: 1861 QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
            QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE
Sbjct: 1861 QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920

Query: 1921 GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL 1980
            GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL
Sbjct: 1921 GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL 1980

Query: 1981 IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA 2040
            IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA
Sbjct: 1981 IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA 2040

Query: 2041 HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH 2100
            HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH
Sbjct: 2041 HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH 2100

Query: 2101 MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG 2160
            MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG
Sbjct: 2101 MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG 2160

Query: 2161 QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES 2220
            QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES
Sbjct: 2161 QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES 2220

Query: 2221 KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV 2280
            KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV
Sbjct: 2221 KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV 2280

Query: 2281 IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF 2340
            IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF
Sbjct: 2281 IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF 2340

Query: 2341 VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD 2400
            VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD
Sbjct: 2341 VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD 2400

Query: 2401 RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL 2460
            RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL
Sbjct: 2401 RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL 2460

Query: 2461 VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH 2520
            VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH
Sbjct: 2461 VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH 2520

Query: 2521 VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD 2580
            VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD
Sbjct: 2521 VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD 2580

Query: 2581 SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP 2640
            SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP
Sbjct: 2581 SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP 2640

Query: 2641 LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM 2700
            LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM
Sbjct: 2641 LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM 2700

Query: 2701 PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE 2760
            PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE
Sbjct: 2701 PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE 2760

Query: 2761 YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE 2820
            YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE
Sbjct: 2761 YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE 2820

Query: 2821 WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE 2880
            WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE
Sbjct: 2821 WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE 2880

Query: 2881 NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG 2940
            NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG
Sbjct: 2881 NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG 2940

Query: 2941 LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK 3000
            LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK
Sbjct: 2941 LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK 3000

Query: 3001 ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD 3060
            ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD
Sbjct: 3001 ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD 3060

Query: 3061 APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART 3120
            APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART
Sbjct: 3061 APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART 3120

Query: 3121 QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN 3180
            QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN
Sbjct: 3121 QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN 3180

Query: 3181 TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC 3240
            TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC
Sbjct: 3181 TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC 3240

Query: 3241 PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA 3300
            PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA
Sbjct: 3241 PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA 3300

Query: 3301 PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP 3360
            PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP
Sbjct: 3301 PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP 3360

Query: 3361 TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR 3420
            TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR
Sbjct: 3361 TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR 3420

Query: 3421 AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK 3480
            AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK
Sbjct: 3421 AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK 3480

Query: 3481 AGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY 3540
                 SGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY
Sbjct: 3481 -----SGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY 3535

Query: 3541 ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS 3600
            ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS
Sbjct: 3536 ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS 3595

Query: 3601 AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA 3660
            AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA
Sbjct: 3596 AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA 3655

Query: 3661 WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY 3720
            WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY
Sbjct: 3656 WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY 3715

Query: 3721 LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ 3780
            LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ
Sbjct: 3716 LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ 3775

Query: 3781 MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV 3840
            MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV
Sbjct: 3776 MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV 3835

Query: 3841 LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN 3900
            LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN
Sbjct: 3836 LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN 3895

Query: 3901 YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV 3960
            YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV
Sbjct: 3896 YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV 3955

Query: 3961 FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK 4020
            FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK
Sbjct: 3956 FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK 4015

Query: 4021 DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV 4080
            DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV
Sbjct: 4016 DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV 4075

Query: 4081 TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF 4140
            TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF
Sbjct: 4076 TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF 4135

Query: 4141 NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN 4200
            NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN
Sbjct: 4136 NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN 4195

Query: 4201 RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD 4260
            RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD
Sbjct: 4196 RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD 4255

Query: 4261 EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL 4320
            EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL
Sbjct: 4256 EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL 4315

Query: 4321 RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL 4380
            RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL
Sbjct: 4316 RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL 4375

Query: 4381 AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV 4440
            AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV
Sbjct: 4376 AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV 4435

Query: 4441 TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE 4500
            TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE
Sbjct: 4436 TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE 4495

Query: 4501 PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF 4560
            PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF
Sbjct: 4496 PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF 4555

Query: 4561 YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA 4620
            YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA
Sbjct: 4556 YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA 4615

Query: 4621 EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR 4680
            EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR
Sbjct: 4616 EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR 4675

Query: 4681 KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE 4740
            KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE
Sbjct: 4676 KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE 4735

Query: 4741 LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS 4800
            LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS
Sbjct: 4736 LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS 4795

Query: 4801 LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF 4860
            LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF
Sbjct: 4796 LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF 4855

Query: 4861 RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT 4920
            RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT
Sbjct: 4856 RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT 4915

Query: 4921 FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT 4980
            FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT
Sbjct: 4916 FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT 4975

Query: 4981 LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5038
            LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS
Sbjct: 4976 LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5033


>gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]
          Length = 4967

 Score = 6623 bits (17183), Expect = 0.0
 Identities = 3307/5078 (65%), Positives = 4025/5078 (79%), Gaps = 160/5078 (3%)

Query: 5    EGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAIC 64
            EGEDE+QFLRTDDEVVLQC+AT+ KEQ KLCLAAEGFGNRLCFLE TSN++NVPPDL+IC
Sbjct: 6    EGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSIC 65

Query: 65   CFVLEQSLSVRALQEMLANTVEAG------------VESSQGGGHRTLLYGHAILLRHAH 112
             FVLEQSLSVRALQEMLANTVE              ++++QGGGHRTLLYGHAILLRH++
Sbjct: 66   TFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSY 125

Query: 113  SRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVS 172
            S MYL CL+TSRS TDKLAFDVGLQED TGEACWWT+HPASKQRSEGEKVRVGDD+ILVS
Sbjct: 126  SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS 185

Query: 173  VSSERYLHLSTASGELQVDASFMQTLWNMNPICSRCE--EGFVTGGHVLRLFHGHMDECL 230
            VSSERYLHLS  +G L VDA+F QTLW++ PI S  E  +G++ GG VLRL HGHMDECL
Sbjct: 186  VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECL 245

Query: 231  TISPAD-SDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQY 289
            T+   +  ++QRR V+YEGGAV  HARSLWRLE LR++WSGSH+RWGQP R+RHVTTG+Y
Sbjct: 246  TVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKY 305

Query: 290  LALTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQH 349
            L+L ED+ L+++D  KA  K+T+F FR SKEKLDV  +++V+GMG  EIKYG+S+C++QH
Sbjct: 306  LSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQH 365

Query: 350  VASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGL 409
            V +GLWLTY + D K++R+G +++KA++H EGHMDD +SL+R Q EES+ AR+I ST  L
Sbjct: 366  VDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFL 425

Query: 410  YNQFIKSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRS 469
            +N+FI+ LD+ S K + S       LPIE V LSLQDLI YF PP E L+HE+KQ++LR+
Sbjct: 426  FNRFIRGLDALSKKAKAST----VDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRA 481

Query: 470  LRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLI 529
            L+NRQ+LFQEEGM+++VL CIDRL+VY++AAHFA+ AG EA ESWK I+N LYELLA+LI
Sbjct: 482  LKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALI 541

Query: 530  RGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLL 589
            RGNR NCA FS +LDWL+S+L+RLEASSGILEVL+CVL+ESPE LNII+E HIKSIISLL
Sbjct: 542  RGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLL 601

Query: 590  DKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFV 649
            DKHGRNHKVLDVLCSLCVC+GVAVRSNQ LI +NLLPGR+LLLQT L+N+V+S+RPNIF+
Sbjct: 602  DKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFL 661

Query: 650  GRAEGTTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDD 709
            G +EG+ QY KWY+E+MVD   PF+TA+ATHLRVGWA TEGY+PYPG GE WGGNGVGDD
Sbjct: 662  GVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDD 721

Query: 710  LYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFES 769
            L+SYGFDGLHLW+G +AR V+SP QHLL  +DVISCCLDLS PSISFRING PVQG+FE+
Sbjct: 722  LFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFEN 781

Query: 770  FNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYR 829
            FN+DGLFFPVVSFSAG+KVRFLLGGRHGEFKFLPPPGYAPC+EAVLP+E+L +E  +EY+
Sbjct: 782  FNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYK 841

Query: 830  REGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQG 889
            +E      L+GP+  L+   F P PVDT QIVLPPHLERIREKLAENIHELW + +IE G
Sbjct: 842  QERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELG 901

Query: 890  WTYGPVRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNL 949
            W YGPVRDDNKR HPCLV+F  LPE ERNYNLQMS ETLKTLLALGCHVG++DE AED +
Sbjct: 902  WQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKV 961

Query: 950  KKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAV 1009
            KK KLPK Y +++GYKPAP+DLS ++LTP+Q  +VD+LAEN HNVWARDR+ QGW+Y   
Sbjct: 962  KKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQ 1021

Query: 1010 QDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVEN--QSR 1067
            QD+  RRNPRLVPY LLD+ TK+SN+DSL +AVRTLLGYGYN+E PDQ+ +         
Sbjct: 1022 QDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGT 1081

Query: 1068 CDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHR 1127
             +R RIFRAEK+Y V++GRWYFEFE VT G+MRVGW+RP  +PD ELG+DE A+ F+G +
Sbjct: 1082 GERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFK 1141

Query: 1128 GQRWHLGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGF 1187
             QRWH G+E +GR WQ GDVVGCM+D+ E+T++FTLNGE+L+ DSGSE AF++ ++GDGF
Sbjct: 1142 AQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGF 1201

Query: 1188 LPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPV 1247
            +PVCSLG  QVG +N G+DVS+L++F ICGLQEG+EPFA+N  R +T W SK LPQF  V
Sbjct: 1202 IPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQV 1261

Query: 1248 PLEHPHYEVSRVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHF-RCTAGA 1306
            P  H H EV+R+DGT+D+ PCL++T +++GSQNS  +++F RLS+P++  + F +  AG 
Sbjct: 1262 PSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGG 1321

Query: 1307 TPLAPPGLQPPAEDEARAAEPDPDYENLRRSAGGW---SEAENGKEGTAKEGAPGGTPQA 1363
             P A  GL  P  D     + D D+E L ++A G       +  KE T  E         
Sbjct: 1322 LPGA--GLFGPKND-LEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPE--------- 1369

Query: 1364 GGEAQPARAENEKDATTEK--NKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRD 1421
                      N KD   EK    K+ FL +  K    T   A     RL  DV+ AD+RD
Sbjct: 1370 --------FNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSA-----RLTEDVL-ADDRD 1415

Query: 1422 DPEIILNTTTYYYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGN 1481
            D + ++ T+TYYYSVR+F GQEP+ VW GW+T D+HQ+D  FDL +VR VTVT+GDE+G 
Sbjct: 1416 DYDFLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGK 1475

Query: 1482 VHSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQV 1541
            VH S+K SNCYMV  G+ +SPG QGR ++  L IGC+VD A+GL+TF ANGKE +T++QV
Sbjct: 1476 VHESIKRSNCYMVCAGESMSPG-QGR-NNNGLEIGCVVDAASGLLTFIANGKELSTYYQV 1533

Query: 1542 EPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMP 1601
            EP+TKLFPAVF   T  NV QFELG+ KN+MPLSA +F+SE KNP PQCPPRL +Q L  
Sbjct: 1534 EPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSH 1593

Query: 1602 VSWSRMPNHFLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRF 1661
            V WSRMPN FL+V+  R  ER GW VQC +PL  M+LHIPEENR +DILEL+E+ +L +F
Sbjct: 1594 VLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKF 1653

Query: 1662 HSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLES 1721
            H HTLRLY AVCALGN+RVAHALCSHVD+ QLL+A+E+ ++PG LRAGYYDLLI IHL S
Sbjct: 1654 HYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSS 1713

Query: 1722 ACRSRRSMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPC 1781
               +R  M +EYIVP+T ET++ITLFP      + + +HGLPG+G++TSLRP   FS P 
Sbjct: 1714 YATARLMMNNEYIVPMTEETKSITLFP------DENKKHGLPGIGLSTSLRPRMQFSSPS 1767

Query: 1782 FVAALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPV 1841
            FV+       +    + SP  PL+ L+ K ++ML EAV++G  HARDPVGG+ EF FVP+
Sbjct: 1768 FVS------ISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPL 1821

Query: 1842 LKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQ 1901
            +KL  TLL+MGIF +ED+K IL++IEP VF E    E      EE D  EKE   ++   
Sbjct: 1822 IKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPE------EESDTLEKELSVDDAKL 1875

Query: 1902 EKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAF 1961
            +       EEEA  G++    +EGLLQMKLPE VKLQMC LL+Y CD +++HR+E++ AF
Sbjct: 1876 QGAG----EEEAKGGKRP---KEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAF 1928

Query: 1962 AERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDC 2021
            ++ +V KLQ NQR RY  +++A +M+AA TAR+T+EFRSPPQEQINMLL FKD  D+ +C
Sbjct: 1929 SDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKD--DKSEC 1986

Query: 2022 PLPEEIRQDLLDFHQDLLAHCGIQLDGEEE-EPEEETTLGSRLMSLLEKVRLVKKKE-EK 2079
            P PEEIR  LLDFH+DL+ HCGI+LD +   +   + T+  RL+SL+EKV  +KKK+ EK
Sbjct: 1987 PCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEK 2046

Query: 2080 PEEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALP 2139
            P E   ++  K  +LQ+L+S  +VRWAQE  ++ PELVRAMF LLHRQYDG+G L+RALP
Sbjct: 2047 PVE---SDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALP 2103

Query: 2140 RAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMR 2199
            + YTI+  SVEDT++LL  LGQIRSLL V+MG +EE LMI+ +G+IMNNKVFYQHPNLMR
Sbjct: 2104 KTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMR 2163

Query: 2200 ALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLE 2259
            ALGMHETVMEVMVNVLGGGESKEI FPKMV +CCRFLCYFCRISRQNQ++MFDHLSYLLE
Sbjct: 2164 ALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLE 2223

Query: 2260 NSGIGL---GMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAK 2316
            NS +GL    M+GSTPLDVAAASV+DNNELALAL+E DLEKVV YLAGCGLQSC MLV+K
Sbjct: 2224 NSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSK 2283

Query: 2317 GYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGL 2376
            GYPDIGWNP  GERYLDFLRFAVF NGESVEENANVVVRLLIR+PECFGPALRGEGG+GL
Sbjct: 2284 GYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGL 2343

Query: 2377 LAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRC 2436
            LAA+EEAI+I+EDP+RDGP       +     E  E++ +H+G+AIM+FY+ALIDLLGRC
Sbjct: 2344 LAAMEEAIKIAEDPSRDGPSPNSGSSKT-LDTEEEEDDTIHMGNAIMTFYSALIDLLGRC 2402

Query: 2437 APEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVP 2496
            APEMHLI AGKGEA+RIR+ILRSL+PL DLVG+IS+  Q+PT+ KDG +V+P MSA F P
Sbjct: 2403 APEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCP 2462

Query: 2497 DHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCL 2556
            DHKA+MVLFLDRVYGIE QDFLLH+L+VGFLPD+RAAASLDTA  S T+MALALNRYLC 
Sbjct: 2463 DHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCT 2522

Query: 2557 AVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRP 2616
            AVLPL+T+CAPLFAGTEH A ++DS+LHTVYRLS+G SLTKAQRD IE CL+S+C  +RP
Sbjct: 2523 AVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRP 2582

Query: 2617 SMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTR 2676
            SM+QHLLRRLVFDVP+LNE AKMPLKLLTNHYERCWKYYCLP GW NFG  SEEELHL+R
Sbjct: 2583 SMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSR 2642

Query: 2677 KLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFD 2736
            KLFWGIFD+L+ KKY+ EL+++A+PCL A+AGALPPDY++++Y S  EK++++D+EGNF+
Sbjct: 2643 KLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFN 2702

Query: 2737 PRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKT 2796
            P+PV+T N+ IPEKL+ FINK+AE++H+KW+ DK+ N W YGE   +  K  P+++PYK 
Sbjct: 2703 PQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKL 2762

Query: 2797 FSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQ-TYDPREGY 2855
             SEK+KEIYRWPIKESLK M+AW W IE+ REG +      +TR+ISQ++Q + D   GY
Sbjct: 2763 LSEKEKEIYRWPIKESLKTMLAWGWRIERTREG-DSMALYNRTRRISQTSQVSVDAAHGY 2821

Query: 2856 NPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKE 2915
            +P+  D+S VTLSR+L AMAE +AENYHN W +KKK ELE+KGGG HPLLVPYDTLTAKE
Sbjct: 2822 SPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKE 2881

Query: 2916 KARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIA 2975
            KA+DREKAQ++LKFLQ+NGYAV+RG KD+ELD+ SIEKRFA+ FLQQL+R++D + ++I 
Sbjct: 2882 KAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYIL 2941

Query: 2976 HLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKE 3035
              +   S G+ E  P+EQEIKFFAK++LPLI+QYF NH LYFLS  ++ L SGGHASNKE
Sbjct: 2942 EFDG-GSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE 3000

Query: 3036 KEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSF 3095
            KEM+TSLFCKL  LVRHR+SLFG DA ++VNCLHIL ++LDARTVMK+G E VK+ LR+F
Sbjct: 3001 KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF 3060

Query: 3096 FESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDD 3155
             ++A+ED+EK +ENL+ G+ +  R Q KGV Q + YTTVALLP+L++LF+HI QHQFG+D
Sbjct: 3061 LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED 3120

Query: 3156 VILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNA 3215
            +IL+DVQVSCYR L S+Y+LGT+K+ YVE+ R ALGECLA  A A PVAFLE  L+++N 
Sbjct: 3121 LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI 3180

Query: 3216 CSVYTTKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLP 3275
             S+Y TKS RERA L LP +VE++CP+IP LE+LM +I  LAESG RYT+MPHV+E+ LP
Sbjct: 3181 YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP 3240

Query: 3276 MLCSYLPRWWERGPEAPPSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWM 3335
            MLCSY+ RWWE GPE  P      A   CTA+ S+H+N+LLGNIL+II NNLGIDE +WM
Sbjct: 3241 MLCSYMSRWWEHGPENNPER----AEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWM 3296

Query: 3336 KRLAVFAQPIVSRARPELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVR 3395
            KRLAVF+QPI+++ +P+LL++HF+P + +L+K+A  VVSEE+ L+ EA+ +  E ELL+ 
Sbjct: 3297 KRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLIL 3356

Query: 3396 DEFSVLCRDLYALYPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREE 3455
            DEF+ L RDLYA YPLLIR+VD NRA+WL EPNP AEELFRMV E+FIYWSKSHNFKREE
Sbjct: 3357 DEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREE 3416

Query: 3456 QNFVVQNEINNMSFLTADNKSKMAKAGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLK 3515
            QNFVVQNEINNMSFL  D KSKM+KA       SDQER K KR+GDRYS+QTSLIVA LK
Sbjct: 3417 QNFVVQNEINNMSFLITDTKSKMSKA-----AVSDQERKKMKRKGDRYSMQTSLIVAALK 3471

Query: 3516 KMLPIGLNMCAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMAL 3575
            ++LPIGLN+CAP DQ+LI LAK R++LKDT++EVR+ + +N+HLQGK+E  P++RWQMAL
Sbjct: 3472 RLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLE-DPAIRWQMAL 3530

Query: 3576 YRGVPGREEDADDPEKIVRRVQEVSAVLYYLDQ------------TEHPYKSKKAVWHKL 3623
            Y+ +P R +D  DPEK V RV +++ VL++L+Q             EHP +SKKAVWHKL
Sbjct: 3531 YKDLPNRTDDTSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKL 3590

Query: 3624 LSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQ 3683
            LSKQR+RAVVACFRM PLYNLP HRA N+FL+ Y+ +WI TE+H FED++I+DL+K G +
Sbjct: 3591 LSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAE 3650

Query: 3684 EEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGE 3743
              EE+E   K+ DPLHQL+L FSRTALTEK KL+ED+LYMAYADIMAKSCH E   E+ +
Sbjct: 3651 PPEEDE-GTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDE---EDDD 3706

Query: 3744 AEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISI 3803
             EEEV+ SFEEK+MEKQ+LLYQQARLH RGAAEMVLQ ISA KGETG MV++TLKLGI+I
Sbjct: 3707 GEEEVK-SFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAI 3765

Query: 3804 LNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGT 3863
            LNGGN+ VQQKMLDYLK+KK+VGFFQS+  LMQ+CSVLDLNAFERQNKAEGLGMV E+G 
Sbjct: 3766 LNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEG- 3824

Query: 3864 VINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLL 3923
                 +GEKV+ DDEFT DLFRFLQLLCEGHN+DFQNYLRTQTGN TT+NIII TVDYLL
Sbjct: 3825 -----SGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLL 3879

Query: 3924 RLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSR 3983
            R+QESISDFYWYYSGKDVI+EQG+RNFSKA+ VAKQVFN+LTEYIQGPCTGNQQSLAHSR
Sbjct: 3880 RVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSR 3939

Query: 3984 LWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQM 4043
            LWDAVVGFLHVFAHM MKL+QDSSQIELLKEL+DLQKDMVVMLLS+LEGNVVNG I +QM
Sbjct: 3940 LWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQM 3999

Query: 4044 VDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFS 4103
            VDMLVESS+NVEMILKFFDMFLKLKD+  S+ F++Y  D +G+ISK+DF KAM+S K ++
Sbjct: 4000 VDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYT 4059

Query: 4104 GPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFL 4163
              E +FLLSC+E DENE ++ EEF  RF EPA+DIGFNVAVLLTNLSEH+P+D RL  FL
Sbjct: 4060 QSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFL 4119

Query: 4164 ELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNE 4223
            ELAES+L YF+P+LGRIEIMG+++RIER+YFEISE++R QWE PQVKESKRQFIFDVVNE
Sbjct: 4120 ELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNE 4179

Query: 4224 GGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETDEDEGAGAAEAGAEGAEEGAAGLE 4283
            GGE EKMELFV+FCEDTIFEMQ+AAQISE +       +  A   E+  E  EE    + 
Sbjct: 4180 GGEKEKMELFVNFCEDTIFEMQLAAQISESD-----LNERSANKEESEKERPEEQGPRMA 4234

Query: 4284 GTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTRA 4343
              +      A   +       +R LS +SL++++++++++T ++  TA  +  W+     
Sbjct: 4235 FFSILTVRSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTL 4294

Query: 4344 GAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDA 4403
                A    G   ++   L GG LVEGAKK+ V ELLA MPDPT DEV G+   G     
Sbjct: 4295 LHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKPL 4354

Query: 4404 DGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPA 4463
            +    SE   D  E   +E + + +       G     +GG ++         + D    
Sbjct: 4355 EAALPSEDLTDLKE-LTEESDLLSD-----IFGLDLKREGGQYKLIPHNPNAGLSDLMSN 4408

Query: 4464 EPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEE-VPEPTPEPP 4522
              P PE    ++ K      +EE   E E + E + EPEKA+ E+GEKEE   E   +  
Sbjct: 4409 PVPMPE----VQEKFQEQKAKEE---EKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQK 4461

Query: 4523 KKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYK 4582
             +Q       + E     FW ++   + K LNY +RNFY +R LALF+AFAINFILLFYK
Sbjct: 4462 LRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYK 4521

Query: 4583 VSDSPPGE-DDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYFLEESTGYME 4641
            VS S   E  ++   ++ + +   S  SS   + A            V+Y LEES+GYME
Sbjct: 4522 VSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIA------------VHYVLEESSGYME 4569

Query: 4642 PALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQ 4701
            P LR L++LHT+++F CIIGY CLKVPLVIFKREKE+ARKLEFDGLYITEQP +DD+KGQ
Sbjct: 4570 PTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQ 4629

Query: 4702 WDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEIT-AHNERKPN 4760
            WDRLV+NT SFP+NYWDKFVKRKV+DK+G+ YGR+RI+ELLGMD A L+ + A  ++KP 
Sbjct: 4630 WDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPK 4689

Query: 4761 PPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMG 4820
                L   L SIDVKYQ+WK GV+FTDNSFLYL WYM MS+LGHYNNFFFAAHLLDIAMG
Sbjct: 4690 KDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMG 4749

Query: 4821 VKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDM 4880
             KTLRTILSSVTHNGKQLV+TVGLLAVVVYLYTVVAFNFFRKFYNKSED D PDMKCDDM
Sbjct: 4750 FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDM 4809

Query: 4881 MTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDA 4940
            +TCY+FHMYVGVRAGGGIGDEIEDPAGDEYE+YR++FDITFFFFVIVILLAIIQGLIIDA
Sbjct: 4810 LTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDA 4869

Query: 4941 FGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKD 5000
            FGELRDQQEQVKEDMETKCFICGIG+DYFDT PHGFETHTL+EHNLANY+FFLMYLINKD
Sbjct: 4870 FGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKD 4929

Query: 5001 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5038
            ETEHTGQESYVWKMYQERCW+FFPAGDCFRKQYEDQL+
Sbjct: 4930 ETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN 4967


>gi|126032338 ryanodine receptor 3 [Homo sapiens]
          Length = 4870

 Score = 4771 bits (12374), Expect = 0.0
 Identities = 2379/3637 (65%), Positives = 2894/3637 (79%), Gaps = 109/3637 (2%)

Query: 1424 EIILNTTTY-YYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNV 1482
            EI+ +TTT  YY++R+FAGQ+PSCVW GWVTPDYH +   FDL+K   VTVT+GDE+G V
Sbjct: 1319 EILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRV 1378

Query: 1483 HSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVE 1542
            H S+K SNCYMVWGGD V+  Q+   S+ DL IGCLVDLA G+++F+ANGKE  T +QVE
Sbjct: 1379 HESVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVE 1438

Query: 1543 PNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPV 1602
            PNTK+FPAVF+ PT  ++ QFELGK KN MPLSAA+F+SE KNP PQCPPRL++Q + PV
Sbjct: 1439 PNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPV 1498

Query: 1603 SWSRMPNHFLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFH 1662
             WSRMPN FL+VET R  ER GW VQC EPL MMALHIPEENRC+DILEL E+ DL RFH
Sbjct: 1499 LWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFH 1558

Query: 1663 SHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESA 1722
             HTLRLY AVCALGN+RVA+ALCSHVD +QL +A+++ +LPG LR+G+YDLLISIHL SA
Sbjct: 1559 YHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASA 1618

Query: 1723 CRSRRSMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCF 1782
               +  M +EYI+P+T  TR I LFP      +   RHGLPGVG+ T L+P   FS PCF
Sbjct: 1619 KERKLMMKNEYIIPITSTTRNIRLFP------DESKRHGLPGVGLRTCLKPGFRFSTPCF 1672

Query: 1783 VAALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVL 1842
            V         E   + SP IPLE+LR KAL ML EAV+  G H RDPVGGSVEFQFVPVL
Sbjct: 1673 VVT------GEDHQKQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVL 1726

Query: 1843 KLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQE 1902
            KL+ TLLVMG+F D+DV+QIL +I+P VF        E   G EE              E
Sbjct: 1727 KLIGTLLVMGVFDDDDVRQILLLIDPSVF-------GEHSAGTEE------------GAE 1767

Query: 1903 KEDEEKEEEEAAEGEKEEGLE---EGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLA 1959
            KE+  + EE+A E  ++ G E   +GLLQ +LPESVKLQMC LL Y CD ELQHRVE++ 
Sbjct: 1768 KEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIV 1827

Query: 1960 AFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEE 2019
            AF + YV KLQANQ+ RY  L++A +M+AA TAR+T+EFRSPPQEQINMLL F+ G   E
Sbjct: 1828 AFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTKEFRSPPQEQINMLLNFQLG---E 1884

Query: 2020 DCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEK 2079
            +CP PEEIR++L DFH+DLL HCG+ L+ EEEE EE+T+   +L +L+ K+    K   K
Sbjct: 1885 NCPCPEEIREELYDFHEDLLLHCGVPLE-EEEEEEEDTSWTGKLCALVYKI----KGPPK 1939

Query: 2080 PEEERSAEESK--PRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRA 2137
            PE+E+  EE +  P +L+EL+S  ++ WAQED +Q  ELVR MF+LL RQYD +GELL+A
Sbjct: 1940 PEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVRMMFNLLRRQYDSIGELLQA 1999

Query: 2138 LPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNL 2197
            L + YTIS +SV DT++LL  LGQIRSLL V+MG +EE LMI  +G+IMNNKVFYQHPNL
Sbjct: 2000 LRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNL 2059

Query: 2198 MRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYL 2257
            MR LGMHETVMEVMVNVLG  E  +I FPKMV SCCRFLCYFCRISRQNQ++MF+HLSYL
Sbjct: 2060 MRVLGMHETVMEVMVNVLGT-EKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYL 2118

Query: 2258 LENSGIGLG---MQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLV 2314
            LENS +GL    M+GSTPLDVAA+SV+DNNELAL+L+E DLEKVV+YLAGCGLQSCPML+
Sbjct: 2119 LENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLEKVVTYLAGCGLQSCPMLL 2178

Query: 2315 AKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGS 2374
            AKGYPD+GWNP  GERYL FLRFAVFVN ESVEENA+VVV+LLIR+PECFGPALRGEGG+
Sbjct: 2179 AKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGN 2238

Query: 2375 GLLAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLG 2434
            GLLAA++ AI+ISE+PA D P  +  +R    G++  EE  VH+G+AIMSFY+ALIDLLG
Sbjct: 2239 GLLAAMQGAIKISENPALDLPS-QGYKREVSTGDDEEEEEIVHMGNAIMSFYSALIDLLG 2297

Query: 2435 RCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASF 2494
            RCAPEMHLIQ GKGEA+RIR+ILRSLVP EDLVGIIS+PL++P+L KDG++ +P M+A+F
Sbjct: 2298 RCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANF 2357

Query: 2495 VPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYL 2554
             PDHKA MVLFLDRVYGI++Q FLLH+L+VGFLPD+RA+ASLDT + STTE ALALNRY+
Sbjct: 2358 CPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYI 2417

Query: 2555 CLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYI 2614
            C AVLPL+T+CAPLFAGTEH   ++DS L T+YRLS+GRSLTKAQRD IE+CL+++C ++
Sbjct: 2418 CSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHL 2477

Query: 2615 RPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHL 2674
            RPSMLQ LLRRLVFDVP LNE+ KMPLKLLTNHYE+CWKYYCLP+GW ++G+  EEELHL
Sbjct: 2478 RPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHL 2537

Query: 2675 TRKLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGN 2734
            T KLFWGIFDSL+HKKYDP+L+RMA+PCL AIAGALPPDY+D   ++  EK+ +VDA+GN
Sbjct: 2538 TEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQISVDADGN 2597

Query: 2735 FDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPY 2794
            FDP+P+ T+N  +PEKL+  + K+AE++H+KWA DK Q+ W YG ++DE +KTHP++RP+
Sbjct: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657

Query: 2795 KTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEE--EKTEKKKTRKISQSAQTYDPR 2852
            KT +EK+KEIYRWP +ESLK M+A  WT+E+ +EGE   ++ E +K R +SQ+ Q     
Sbjct: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQANQG---- 2713

Query: 2853 EGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLT 2912
              Y+P P DLS V LSRELQ M E +AENYHN W +KKK ELE+KGGG+HPLLVPYDTLT
Sbjct: 2714 NSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLT 2773

Query: 2913 AKEKARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQE 2972
            AKEK +DREKAQ+L KFLQ+NG  V+RG+KDMELD+SS+EKRFA+ FL+++L+++D +QE
Sbjct: 2774 AKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQE 2833

Query: 2973 FIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHAS 3032
            FIAHLEA+VSSG+ EKSP +QEIKFFAK+LLPL++QYFT+HCLYFLS+P K L S G+AS
Sbjct: 2834 FIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLSSPLKPLSSSGYAS 2893

Query: 3033 NKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGL 3092
            +KEKEM+  LFCKLAALVRHR+SLFG+D+  +V+CLHILA++LD RTVMKSG E+VKAGL
Sbjct: 2894 HKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGL 2953

Query: 3093 RSFFESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQF 3152
            R+FFE+A+ED+EK  ENL+LGK + +RTQ+KGV QN+ YTTVALLP+LT++F+H+ QHQF
Sbjct: 2954 RAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVTQHQF 3013

Query: 3153 GDDVILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNE 3212
            G D++L DVQ+SCY  LCS+YSLGT KN YVE+ RPALGECLA LAAA+PVAFLEP LN 
Sbjct: 3014 GMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNR 3073

Query: 3213 YNACSVYTTKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEI 3272
            YN  SV+ TK+PRER+ILG+P++VE+MCPDIP LE LM +I  LAESGARYTEMPHVIE+
Sbjct: 3074 YNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEV 3133

Query: 3273 TLPMLCSYLPRWWERGPEAPPSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEA 3332
             LPMLC+YL  WWERGPE     LP    P CT VTS+HL+ +LGNIL+II NNLGIDEA
Sbjct: 3134 ILPMLCNYLSYWWERGPEN----LPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEA 3189

Query: 3333 SWMKRLAVFAQPIVSRARPELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGEL 3392
            SWMKR+AV+AQPI+S+ARP+LL+SHFIPT+ +L+K+A K V EEEQL+ + K + QE EL
Sbjct: 3190 SWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADGKGDTQEAEL 3249

Query: 3393 LVRDEFSVLCRDLYALYPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFK 3452
            L+ DEF+VLCRDLYA YP+LIRYVDNNR+ WL  P+  +++LFRMV E+FI W KSHNFK
Sbjct: 3250 LILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFK 3309

Query: 3453 REEQNFVVQNEINNMSFLTADNKSKMAKAGDIQSGGSDQERTKKKRRGDRYSVQTSLIVA 3512
            REEQNFV+QNEINN++FLT D+KSKM+KA  ++SGG DQER K KRRGD YS+QTSLIVA
Sbjct: 3310 REEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVA 3369

Query: 3513 TLKKMLPIGLNMCAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQ 3572
             LKKMLPIGLNMC P DQ+LI+LAK+RY+ +DTDEEVRE L NNLHLQ K +  P+++WQ
Sbjct: 3370 ALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKSD-DPAVKWQ 3428

Query: 3573 MALYRGVPGREEDADDPEKIVRRVQEVSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAV 3632
            + LY+ V  + E+  +PEK V RVQ +SA +++L+Q E P +SKKAVWHKLLSKQR+RAV
Sbjct: 3429 LNLYKDVL-KSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAV 3487

Query: 3633 VACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEE 3692
            VACFRM PLYNLP HR+ N+FL  Y+  WI TE++SFE++++ DL+K+ + EEEEEE  E
Sbjct: 3488 VACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEETE 3547

Query: 3693 KKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEEVEVSF 3752
            K+PDPLHQ++L+FSR ALTE+SKL++D LY +Y+ +MAKSC   + GE+ E +E+ E +F
Sbjct: 3548 KQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSC---QSGEDEEEDEDKEKTF 3604

Query: 3753 EEKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQ 3812
            EEK+MEKQ+ LYQQARLH RGAAEMVLQMISA KGE   MV  TLKLGI+ILNGGNA VQ
Sbjct: 3605 EEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQ 3664

Query: 3813 QKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEK 3872
            QKMLDYLK+KK+ GFFQS+  LMQ+CSVLDLNAFERQNKAEGLGMV E+GT+I R+ GEK
Sbjct: 3665 QKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEK 3724

Query: 3873 VMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDF 3932
            V+ +DEFT+DLFRFLQLLCEGHN+DFQN+LRTQ GNTTT+N+II TVDYLLRLQESISDF
Sbjct: 3725 VLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDF 3784

Query: 3933 YWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFL 3992
            YWYYSGKD+I+E G+ NFSKA++V KQ+FNSLTEYIQGPC GNQQSLAHSRLWDAVVGFL
Sbjct: 3785 YWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFL 3844

Query: 3993 HVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSS 4052
            HVFA+M MKL+QDSSQIELLKELLDL +DMVVMLLSLLEGNVVNG I +QMVD LVESS+
Sbjct: 3845 HVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESST 3904

Query: 4053 NVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLS 4112
            NVEMILKFFDMFLKLKD+  S+ F++Y  D +G+ISKK+FQKAM+ QKQ++  EI FLLS
Sbjct: 3905 NVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLS 3964

Query: 4113 CSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLELAESILEY 4172
            C+EADEN+M N  +F +RF EPA+DIGFNVAVLLTNLSEH+P+D RL   L+ AES+L Y
Sbjct: 3965 CAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNY 4024

Query: 4173 FRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMEL 4232
            F PYLGRIEIMG +++IER+YFEISE++R QWE PQVKESKRQFIFDVVNEGGE EKMEL
Sbjct: 4025 FEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMEL 4084

Query: 4233 FVSFCEDTIFEMQIAAQISEPEG--EPETDEDEGAGAAEAGAEGAEEGAAGLEGTAATAA 4290
            FV+FCEDTIFEMQ+A+QISE +    PE +E++   +      G EE    LE   A+A 
Sbjct: 4085 FVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLE--PASAF 4142

Query: 4291 AGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTRAGAAGAGA 4350
            A A A V       L+  + ++LR++ R ++++TA+E    + +  W             
Sbjct: 4143 AMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLFTI 4202

Query: 4351 AAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDADGEGASE 4410
              G   +LW ++FGGGLVEGAK + VT++L  MPDPT   +H +       +    G + 
Sbjct: 4203 LGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGITT 4262

Query: 4411 GAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTT-PAEPPTPE 4469
                  +G   + + + +         +     G  +     GLGD+ +     EPPT E
Sbjct: 4263 ELVHFIKGEKGDTDIMSDL------FGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLE 4316

Query: 4470 GSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPE--------- 4520
             +   KRK       +    +   E E ++E EKAD E+GEKE+  +   +         
Sbjct: 4317 STVQKKRK------AQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVT 4370

Query: 4521 PPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLF 4580
              KK+       K E     F+  LE+ + K L+YL+RNFY LRFLALF+AFAINFILLF
Sbjct: 4371 KKKKRRCGQKVEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLF 4430

Query: 4581 YKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYFLEESTGYM 4640
            YKV++ P  E+        DV+         W     EE    E+E MV++ L+ESTGYM
Sbjct: 4431 YKVTEEPLEEE------TEDVANL-------WNSFNDEE----EEEAMVFFVLQESTGYM 4473

Query: 4641 EPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKG 4700
             P LR L+++HT+++ +C++GY CLKVPLV+FKREKE+ARKLEFDGLYITEQP +DD+KG
Sbjct: 4474 APTLRALAIIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKG 4533

Query: 4701 QWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEITAHNERKPN 4760
            QWDRLV+NTPSFP+NYWDKFVKRKV++K+GD+YG ERIAELLG+D   L+ +   E K  
Sbjct: 4534 QWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAE 4593

Query: 4761 PPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMG 4820
                L++WL SID+KY IWK GV+FTDNSFLYL WY  MS+LGHYNNFFFAAHLLDIAMG
Sbjct: 4594 -AASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMG 4652

Query: 4821 VKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDM 4880
             KTLRTILSSVTHNGKQLV+TVGLLAVVVYLYTVVAFNFFRKFYNKSED+DEPDMKCDDM
Sbjct: 4653 FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDM 4712

Query: 4881 MTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDA 4940
            MTCYLFHMYVGVRAGGGIGDEIEDPAGD YE+YR+VFDITFFFFVIVILLAIIQGLIIDA
Sbjct: 4713 MTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDA 4772

Query: 4941 FGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKD 5000
            FGELRDQQEQV+EDMETKCFICGIG+DYFDTTPHGFETHTL+EHNLANY+FFLMYLINKD
Sbjct: 4773 FGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKD 4832

Query: 5001 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL 5037
            ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL
Sbjct: 4833 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL 4869



 Score = 1896 bits (4911), Expect = 0.0
 Identities = 906/1308 (69%), Positives = 1084/1308 (82%), Gaps = 20/1308 (1%)

Query: 2    GDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDL 61
            G   GEDE+QFLRT+DEVVLQC AT+ KEQ K CLAAEG GNRLCFLEPTS A+ +PPDL
Sbjct: 4    GGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDL 63

Query: 62   AICCFVLEQSLSVRALQEMLANTVEAGVE-SSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120
             +C FVLEQSLSVRALQEMLANT E G E ++QGGGHRTLLYGHA+LLRH+ S MYL+CL
Sbjct: 64   CVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYLTCL 123

Query: 121  TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180
            TTSRS TDKLAFDVGL+E ATGEACWWT+HPASKQRSEGEKVR+GDD+ILVSVSSERYLH
Sbjct: 124  TTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLH 183

Query: 181  LSTASGELQVDASFMQTLWNMNPICS--RCEEGFVTGGHVLRLFHGHMDECLTISPADSD 238
            LS ++G +QVDASFMQTLWN++P CS    EEG++ GGHV+RLFHGH DECLTI   D +
Sbjct: 184  LSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGH-DECLTIPSTDQN 242

Query: 239  D-QRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQG 297
            D Q R ++YE G   T ARSLWR+EPLRISWSGS++RWGQ  R+RH+TTG YLALTEDQG
Sbjct: 243  DSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQG 302

Query: 298  LVVVDASKAHTKATSFCFRISKE---KLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGL 354
            L++ D +K+ TK+T+F FR SKE   KLD + KRD+EGMG PEIKYG+S+CFVQH+ASGL
Sbjct: 303  LILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIASGL 362

Query: 355  WLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFI 414
            W+TY A D K  RLG LK+K +LHQEGHMDD L+L RCQ+EESQAAR+I +T  L++QF+
Sbjct: 363  WVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFV 422

Query: 415  KSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQ 474
                  SG  R + P     LPIE V+ +LQDLI YF+PP E+++HE+KQ+KLRSL+NRQ
Sbjct: 423  ------SGNNRTAAP---ITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQ 473

Query: 475  SLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRS 534
            +LF+EEGML++VLNCIDRLNVY + AHFA  A EE+  +WKEI+NLLY+LLA+LIRGNR+
Sbjct: 474  NLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRN 533

Query: 535  NCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGR 594
            NCA FS NLDWL+SKLDRLE+SSGILEVL+C+L ESPE LN+I E HIKSIISLLDKHGR
Sbjct: 534  NCAQFSNNLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGR 593

Query: 595  NHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEG 654
            NHKVLD+LCSLC+CNGVAVR+NQ+LI +NLLP R LLLQT LIN VTSIRPNIF+G AEG
Sbjct: 594  NHKVLDILCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEG 653

Query: 655  TTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYG 714
            + QY KWYFE+++D+V PFLTA+ THLRVGWA + GY PYPG GEGWGGNGVGDDLYSYG
Sbjct: 654  SAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYG 713

Query: 715  FDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDG 774
            FDGLHLW+G + R V S  QHLL  +DV+SCCLDL VPSISFRING PVQG+FE+FN DG
Sbjct: 714  FDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDG 773

Query: 775  LFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPR 834
            LFFPV+SFSAGVKVRFL+GGRHGEFKFLPP GYAPC+EA+LP+E++ LEP+KEY+R+   
Sbjct: 774  LFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADG 833

Query: 835  GPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGP 894
               L+G ++ LS   F+PCPVDT Q++LPPHLE+IR++LAENIHELW + +IE GWT+G 
Sbjct: 834  IRDLLGTTQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGK 893

Query: 895  VRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKL 954
            +RDDNKR HPCLV+F  LPE E+NYNLQMS ETLKTLLALGCH+   +  AE++LKK KL
Sbjct: 894  IRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKL 953

Query: 955  PKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPA 1014
            PK YMMSNGYKPAPLDLS V+L P Q  LVD+LAEN HNVWA+DR+ QGW+Y   QD+  
Sbjct: 954  PKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKN 1013

Query: 1015 RRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQE--PSQVENQSRCDRVR 1072
            +RNPRLVPY LLDE TK+SNRDSL +AVRT +GYGYNIEP DQE   S VE  S  D++R
Sbjct: 1014 KRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVS-IDKIR 1072

Query: 1073 IFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWH 1132
             FR E+SY V+SG+WYFEFE VT G+MRVGWARP  RPDVELGAD+ A+VF G+RGQRWH
Sbjct: 1073 FFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWH 1132

Query: 1133 LGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCS 1192
             GS  FGR WQPGDVVGCMI+L + ++IFTLNGE+L+++ GSE AF + EI +GF+P+C 
Sbjct: 1133 QGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICC 1192

Query: 1193 LGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHP 1252
            LG  Q+G +NLG D S+ +F+ +CGLQEGFEPFA+NM R V  WFSK LP F  VP +HP
Sbjct: 1193 LGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHP 1252

Query: 1253 HYEVSRVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHF 1300
            H EV R+DGT+D+PPCL++TH+T+G+QNS  +M++ RLS+PV+ H  F
Sbjct: 1253 HIEVMRIDGTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSF 1300



 Score =  109 bits (273), Expect = 6e-23
 Identities = 71/232 (30%), Positives = 111/232 (47%), Gaps = 20/232 (8%)

Query: 2731 AEGNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPM 2790
            ++ +F P PV+T  VI+P  L+   ++ AE  HE W  +KI+  W++G+  D+  + HP 
Sbjct: 845  SQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPC 904

Query: 2791 LRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYD 2850
            L  +    E +K        E+LK ++A    I       EE  +K K  K       Y 
Sbjct: 905  LVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPK------NYM 958

Query: 2851 PREGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKK---------KQELEAKGGGT 2901
               GY P P DLS V L    + + ++LAEN HN W + +         +Q+L+ K    
Sbjct: 959  MSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNK---R 1015

Query: 2902 HPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEK 2953
            +P LVPY  L  + K  +R+  +E ++     GY +     D EL  S++EK
Sbjct: 1016 NPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEP--SDQELADSAVEK 1065



 Score =  103 bits (258), Expect = 3e-21
 Identities = 66/193 (34%), Positives = 101/193 (52%), Gaps = 12/193 (6%)

Query: 849  DFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVD 908
            +F P P++T+   LP  LE I  K AE+ H+ WA  + + GW YG   D+N + HP +  
Sbjct: 2597 NFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRP 2656

Query: 909  FHSLPEPERNYNLQMSGETLKTLLALGCHV-----GMADEKAEDNLKKTKLPKTYMMSNG 963
            F +L E E+      + E+LKT+LA+G  V     G A  +  +N +K +        N 
Sbjct: 2657 FKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQREN-EKLRSVSQANQGNS 2715

Query: 964  YKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPY 1023
            Y PAPLDLS+V L+     +V+ +AEN HN+WA+ +  +      ++      +P LVPY
Sbjct: 2716 YSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLE------LESKGGGSHPLLVPY 2769

Query: 1024 RLLDEATKRSNRD 1036
              L    K  +R+
Sbjct: 2770 DTLTAKEKFKDRE 2782



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 25/102 (24%), Positives = 50/102 (49%)

Query: 964  YKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPY 1023
            + P P++  +  L      +V + AE+ H+ WA D+   GW Y    D   + +P + P+
Sbjct: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657

Query: 1024 RLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQ 1065
            + L E  K   R    ++++T+L  G+ +E   +  + V+ +
Sbjct: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQR 2699


>gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo
            sapiens]
          Length = 2701

 Score =  167 bits (423), Expect = 2e-40
 Identities = 93/292 (31%), Positives = 157/292 (53%), Gaps = 49/292 (16%)

Query: 4781 FGVIFTDNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLV 4839
            +  +  D +FLY   Y+++ +LG + + FF++  L D+    +TL  ++ SVT NG+ ++
Sbjct: 2337 YRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSII 2396

Query: 4840 MTVGLLAVVVYLYTVVAFNFFRKFYNKSED------------------------------ 4869
            +T  L  ++VYL++++ F F +  +    D                              
Sbjct: 2397 LTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKEN 2456

Query: 4870 ---------------EDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELY- 4913
                           ED  +  CD ++ C +  +  G+R GGG+GD +  P+ DE  L+ 
Sbjct: 2457 CSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDE-PLFA 2515

Query: 4914 -RVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTT 4972
             RVV+D+ F+F VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+  D FD  
Sbjct: 2516 ARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNK 2575

Query: 4973 PHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
               FE H   EHN+ +Y++F++ +  KD TE+TG ESYV +M  E+  D+FP
Sbjct: 2576 TVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFP 2627



 Score =  101 bits (252), Expect = 2e-20
 Identities = 138/595 (23%), Positives = 235/595 (39%), Gaps = 97/595 (16%)

Query: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATG-EACWWTMHPASKQRSEGE 160
           Y + I L H  S  YL+      ++ +K A  V L  DA G E  W+ +HP  K RSEG+
Sbjct: 117 YSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSL--DAAGNEGSWFYIHPFWKLRSEGD 174

Query: 161 KVRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFV 213
            + VGD ++L+ V++ + LH S        G  +V+A    T W +      S   E  +
Sbjct: 175 NIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVL 234

Query: 214 TGGHVLRLFHGHMDECLTISPADSDDQ--RRLVYYEGGAVCTHARSLWRLEPLRIS-WSG 270
            GG V+RLFH   ++ LT    +       R    +     T +++LW +E +      G
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRG 294

Query: 271 SHLRWGQPLRVRHVTTGQYLAL--------TEDQGLVVVD-----ASKAHTKATSFCFRI 317
              +W    R +H+ TG YLA          +++G  V D     + K         + +
Sbjct: 295 GAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTL 354

Query: 318 ----------SKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA------- 360
                     S  +LD    +  + + P       S   ++H+ +  W+T  +       
Sbjct: 355 VSVPHGNDIASLFELDATTLQRADCLVP-----RNSYVRLRHLCTNTWVTSTSIPIDTDE 409

Query: 361 PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420
             P  L++G  + K          +A ++      E +     +  N +    +K L++ 
Sbjct: 410 ERPVMLKIGTCQTK-------EDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLEN- 461

Query: 421 SGKPRGSGPPAGTALPIEG--VILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQ 478
                      GT    E   V   L+DLI +      + Q        +  R RQ L +
Sbjct: 462 -----------GTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMR 510

Query: 479 EEGMLSMVLNCIDRLNVYTTAAHFAEFAGE-----------EAAESWKEIVNLLYELLAS 527
           E+ +L+ V   +         A F E AGE           +    +K ++ L Y +L  
Sbjct: 511 EQNILAQVFGIL--------KAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRH 562

Query: 528 LIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSI 585
             +  R N    + N   + S++        + E     L+ +   L    I    I++ 
Sbjct: 563 SQQDYRKNQEYIAKNFCVMQSQI----GYDILAEDTITALLHNNRKLLEKHITAKEIETF 618

Query: 586 ISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLL-PGR-ELLLQTNLIN 638
           +SLL +  R  + LD L  LCV N  A+   Q+LI + +L PG  ++L+QT +++
Sbjct: 619 VSLL-RRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVS 672



 Score = 74.3 bits (181), Expect = 3e-12
 Identities = 127/548 (23%), Positives = 209/548 (38%), Gaps = 153/548 (27%)

Query: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKD-KKE 3824
            Q  L   GA+E+V+ +I   K +   + S  + LGI++L GGN + Q      L + KK 
Sbjct: 1746 QCLLDKEGASELVIDVIVNTKNDR--IFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKS 1803

Query: 3825 VGFFQSIQALMQTC-----SVLDLNAFERQNKA------------------------EGL 3855
              FF+ +   M+       S + +N  +  NK                         EG+
Sbjct: 1804 EKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGM 1863

Query: 3856 -GMVNEDGTVINRQ----------------------NGEKVMADD-------EFTQDLFR 3885
             G + E  +  ++                       N E+  A++          Q + R
Sbjct: 1864 KGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILR 1923

Query: 3886 FLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQ 3945
            FLQLLCE HN + QN+LR Q  N T  N++  T+ +L  +  S +       G  ++   
Sbjct: 1924 FLQLLCENHNRELQNFLRNQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL--- 1973

Query: 3946 GKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLA--HSRLWDAVVGFLHVFAHMMMKLA 4003
            G     K +++  Q   SLTEY QGPC  NQ  +A   S   D ++  +    + + K  
Sbjct: 1974 GLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYR 2033

Query: 4004 QDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDM 4063
             D         +L L+ +   +LL+++E                   S N E IL  F+M
Sbjct: 2034 MDL--------VLQLKNNASKLLLAIMESR---------------HDSENAERIL--FNM 2068

Query: 4064 FLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMIN 4123
                               PR L+   D  K   +Q           L C   D      
Sbjct: 2069 ------------------RPRELV---DVMKNAYNQG----------LECDHGD------ 2091

Query: 4124 CEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFL------ELAESILEYFRPYL 4177
             +E  +    P +D+G N+ +L   L+    H+  L   L      +  +  L+Y+  + 
Sbjct: 2092 -DEGGDDGVSP-KDVGHNIYILAHQLAR---HNKLLQQMLKPGSDPDEGDEALKYYANHT 2146

Query: 4178 GRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFC 4237
             +IEI+   R +E+I F +   N  ++     +ESK + +F+      +  K+  F    
Sbjct: 2147 AQIEIVRHDRTMEQIVFPV--PNICEY---LTRESKCR-VFNTTERDEQGSKVNDFFQQT 2200

Query: 4238 EDTIFEMQ 4245
            ED   EM+
Sbjct: 2201 EDLYNEMK 2208



 Score = 46.6 bits (109), Expect = 6e-04
 Identities = 32/143 (22%), Positives = 66/143 (46%), Gaps = 6/143 (4%)

Query: 490  IDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFSTNLDWLVSK 549
            +  +  ++      +   E+  E   E++NL +  L +  RGN  N  L   +L+  ++ 
Sbjct: 1207 LKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLFLTP 1266

Query: 550  LDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCN 609
               LEA     E +  + + +  + N I E  ++  +  ++ HGR+ + L  L ++   +
Sbjct: 1267 -GLLEA-----ETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD 1320

Query: 610  GVAVRSNQDLITENLLPGRELLL 632
            G  V+  QD++   L+ G E +L
Sbjct: 1321 GKYVKKCQDMVMTELINGGEDVL 1343



 Score = 34.7 bits (78), Expect = 2.5
 Identities = 20/74 (27%), Positives = 36/74 (48%), Gaps = 3/74 (4%)

Query: 2185 IMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISR 2244
            + N K   QH  L++ +G H  V++++       E  + +  +++     FL  FCR + 
Sbjct: 1194 VQNKKCRNQHQRLLKNMGAHSVVLDLLQIPY---EKNDEKMNEVMNLAHTFLQNFCRGNP 1250

Query: 2245 QNQRSMFDHLSYLL 2258
            QNQ  +  HL+  L
Sbjct: 1251 QNQVLLHKHLNLFL 1264


>gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isoform 1
            [Homo sapiens]
          Length = 2710

 Score =  166 bits (419), Expect = 7e-40
 Identities = 93/289 (32%), Positives = 156/289 (53%), Gaps = 52/289 (17%)

Query: 4787 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4845
            D  FLY   Y+V+  +G + + FF++  L D+    +TL  ++ SVT NG+ +++T  L 
Sbjct: 2349 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2408

Query: 4846 AVVVYLYTVVAFNFFR-------------------------------------------- 4861
             ++VYL+++V + FF+                                            
Sbjct: 2409 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2468

Query: 4862 ----KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELY--RV 4915
                +     E E + +  C+ ++ C +  +  G+R+GGG+GD +  P+ +E  L+  RV
Sbjct: 2469 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE-PLFAARV 2527

Query: 4916 VFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHG 4975
            ++D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+  D FD     
Sbjct: 2528 IYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVT 2587

Query: 4976 FETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
            FE H  EEHN+ +Y+ F++ +  KD TE+TG ESYV +M +ER  D+FP
Sbjct: 2588 FEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2636



 Score = 82.4 bits (202), Expect = 1e-14
 Identities = 129/585 (22%), Positives = 232/585 (39%), Gaps = 79/585 (13%)

Query: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEK 161
           YG+ I L H  S  YL+      ++ +K A  V L E A  E  W+ + P  K RS G+ 
Sbjct: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175

Query: 162 VRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFVT 214
           V +GD ++L  V++ + LH S+       G  +V++    T W +      S  ++  + 
Sbjct: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235

Query: 215 GGHVLRLFHGHMDECLTISPADSDDQRRLVYY-----EGGAVCTHARSLWRLEPLRIS-W 268
           GG V+RLFH   ++ LT    D   +++ V+      +     T +++LW +E ++    
Sbjct: 236 GGDVVRLFHAEQEKFLT---CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPC 292

Query: 269 SGSHLRWGQPLRVRHVTTGQYLALT-----EDQGLVVVDASKAHTKATSFCFRISKEKL- 322
            G    W    R +H+ TG YLA       E++ L    +      A+    R ++EK+ 
Sbjct: 293 RGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMV 352

Query: 323 ----DVAPKRDVEG---MGPPEIKYGESL------CFVQHVASGLW-------LTYAAPD 362
                V    D+     + P  ++ G+SL        ++H+ +  W       +      
Sbjct: 353 YSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEK 412

Query: 363 PKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSFSG 422
           P  L++G    K          +A ++      E +            N   K L S +G
Sbjct: 413 PVMLKIGTSPVK-------EDKEAFAIVPVSPAEVRDL-------DFANDASKVLGSIAG 458

Query: 423 KPRGSGPPAGTALPIE--GVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480
           K        GT    E   V   L+DL+ +    +   Q   +    +  R RQ L +E+
Sbjct: 459 KLE-----KGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQ 513

Query: 481 GMLSMVLNCIDRLNVYTTAAH----FAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNC 536
            +L  +   +     +T          E  G++    ++ I  L Y +L    +  R N 
Sbjct: 514 NILKQIFKLLQA--PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQ 571

Query: 537 ALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSIISLLDKHGR 594
              +    ++  ++        + E     L+ +   L    I    I + +SL+ K+ R
Sbjct: 572 EYIAKQFGFMQKQI----GYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKN-R 626

Query: 595 NHKVLDVLCSLCVCNGVAVRSNQDLITENLL--PGRELLLQTNLI 637
             + LD L  LCV    ++   Q+LI + +L     ++L++T L+
Sbjct: 627 EPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 671



 Score = 70.9 bits (172), Expect = 3e-11
 Identities = 120/542 (22%), Positives = 205/542 (37%), Gaps = 146/542 (26%)

Query: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3824
            Q  L   GA+ +V+ +I     +   +   ++ L I++L GGN  +Q      L +DKK 
Sbjct: 1756 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1813

Query: 3825 VGFFQSI--------QALMQTCSV-------------LDLNAFERQNKAEGLGMVNEDG- 3862
              FF+          Q +  T +V             +D +A  R+   E    + E+  
Sbjct: 1814 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1873

Query: 3863 --------------TVINR--------QNGEKVMADDEFTQD-------------LFRFL 3887
                          T   R        Q GE   A  +  +D             + RFL
Sbjct: 1874 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1933

Query: 3888 QLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGK 3947
            QLLCE HN D QN+LR Q  N T  N++  T+ +L  +  S +       G  ++   G 
Sbjct: 1934 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1983

Query: 3948 RNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSS 4007
                K +++  Q   SLTEY QGPC  NQ  +A                        +S+
Sbjct: 1984 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2021

Query: 4008 QIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKL 4067
             I+++  L+                N +N  + ++ +D+++E  +N   +L         
Sbjct: 2022 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2056

Query: 4068 KDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEF 4127
              +   E+  D     R L + +  +     +K +   E++F       ++ E  N E+ 
Sbjct: 2057 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-------EDGE--NGEDG 2105

Query: 4128 ANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLEL-----AESILEYFRPYLGRIEI 4182
            A       R++G N+ +L   L+    H+  L + L+       +  LE++  +  +IEI
Sbjct: 2106 A----ASPRNVGHNIYILAHQLAR---HNKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2158

Query: 4183 MGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIF 4242
            +   R +E+I F +             KESK + I+       +  K+  F    ED   
Sbjct: 2159 VRLDRTMEQIVFPVPSICEF-----LTKESKLR-IYYTTERDEQGSKINDFFLRSEDLFN 2212

Query: 4243 EM 4244
            EM
Sbjct: 2213 EM 2214



 Score = 43.9 bits (102), Expect = 0.004
 Identities = 38/175 (21%), Positives = 81/175 (46%), Gaps = 24/175 (13%)

Query: 461  EEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAES-WKEIVN 519
            +E  S  +S + +Q L +  G  ++VL  +             +   E+A ++  +EI+ 
Sbjct: 1190 QESASVRKSRKQQQRLLRNMGAHAVVLELL-------------QIPYEKAEDTKMQEIMR 1236

Query: 520  LLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYC--VLIESPEVLNII 577
            L +E L +   GN+ N AL   +++        L  + GILE +    + + + ++ + I
Sbjct: 1237 LAHEFLQNFCAGNQQNQALLHKHIN--------LFLNPGILEAVTMQHIFMNNFQLCSEI 1288

Query: 578  QENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLL 632
             E  ++  +  ++ HGRN + +  L ++    G  ++  QD++   L+   E +L
Sbjct: 1289 NERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVL 1343


>gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isoform 2
            [Homo sapiens]
          Length = 2695

 Score =  166 bits (419), Expect = 7e-40
 Identities = 93/289 (32%), Positives = 156/289 (53%), Gaps = 52/289 (17%)

Query: 4787 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4845
            D  FLY   Y+V+  +G + + FF++  L D+    +TL  ++ SVT NG+ +++T  L 
Sbjct: 2334 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2393

Query: 4846 AVVVYLYTVVAFNFFR-------------------------------------------- 4861
             ++VYL+++V + FF+                                            
Sbjct: 2394 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2453

Query: 4862 ----KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELY--RV 4915
                +     E E + +  C+ ++ C +  +  G+R+GGG+GD +  P+ +E  L+  RV
Sbjct: 2454 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE-PLFAARV 2512

Query: 4916 VFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHG 4975
            ++D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+  D FD     
Sbjct: 2513 IYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVT 2572

Query: 4976 FETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
            FE H  EEHN+ +Y+ F++ +  KD TE+TG ESYV +M +ER  D+FP
Sbjct: 2573 FEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2621



 Score = 84.0 bits (206), Expect = 4e-15
 Identities = 130/580 (22%), Positives = 231/580 (39%), Gaps = 84/580 (14%)

Query: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEK 161
           YG+ I L H  S  YL+      ++ +K A  V L E A  E  W+ + P  K RS G+ 
Sbjct: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175

Query: 162 VRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFVT 214
           V +GD ++L  V++ + LH S+       G  +V++    T W +      S  ++  + 
Sbjct: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235

Query: 215 GGHVLRLFHGHMDECLTISPADSDDQRRLVYY-----EGGAVCTHARSLWRLEPLRIS-W 268
           GG V+RLFH   ++ LT    D   +++ V+      +     T +++LW +E ++    
Sbjct: 236 GGDVVRLFHAEQEKFLT---CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPC 292

Query: 269 SGSHLRWGQPLRVRHVTTGQYLALTEDQGLVVVDASKAHTKATSFCFRISKEKL-----D 323
            G    W    R +H+ TG YLA   D      DAS++         R ++EK+      
Sbjct: 293 RGGAGYWNSLFRFKHLATGHYLAAEVDPD---QDASRSR-------LRNAQEKMVYSLVS 342

Query: 324 VAPKRDVEG---MGPPEIKYGESL------CFVQHVASGLW-------LTYAAPDPKALR 367
           V    D+     + P  ++ G+SL        ++H+ +  W       +      P  L+
Sbjct: 343 VPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLK 402

Query: 368 LGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSFSGKPRGS 427
           +G    K          +A ++      E +            N   K L S +GK    
Sbjct: 403 IGTSPVK-------EDKEAFAIVPVSPAEVRDL-------DFANDASKVLGSIAGKLE-- 446

Query: 428 GPPAGTALPIE--GVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEGMLSM 485
               GT    E   V   L+DL+ +    +   Q   +    +  R RQ L +E+ +L  
Sbjct: 447 ---KGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQ 503

Query: 486 VLNCIDRLNVYTTAAH----FAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFST 541
           +   +     +T          E  G++    ++ I  L Y +L    +  R N    + 
Sbjct: 504 IFKLLQA--PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAK 561

Query: 542 NLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSIISLLDKHGRNHKVL 599
              ++  ++        + E     L+ +   L    I    I + +SL+ K+ R  + L
Sbjct: 562 QFGFMQKQI----GYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKN-REPRFL 616

Query: 600 DVLCSLCVCNGVAVRSNQDLITENLL--PGRELLLQTNLI 637
           D L  LCV    ++   Q+LI + +L     ++L++T L+
Sbjct: 617 DYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 656



 Score = 70.9 bits (172), Expect = 3e-11
 Identities = 120/542 (22%), Positives = 205/542 (37%), Gaps = 146/542 (26%)

Query: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3824
            Q  L   GA+ +V+ +I     +   +   ++ L I++L GGN  +Q      L +DKK 
Sbjct: 1741 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1798

Query: 3825 VGFFQSI--------QALMQTCSV-------------LDLNAFERQNKAEGLGMVNEDG- 3862
              FF+          Q +  T +V             +D +A  R+   E    + E+  
Sbjct: 1799 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1858

Query: 3863 --------------TVINR--------QNGEKVMADDEFTQD-------------LFRFL 3887
                          T   R        Q GE   A  +  +D             + RFL
Sbjct: 1859 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1918

Query: 3888 QLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGK 3947
            QLLCE HN D QN+LR Q  N T  N++  T+ +L  +  S +       G  ++   G 
Sbjct: 1919 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1968

Query: 3948 RNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSS 4007
                K +++  Q   SLTEY QGPC  NQ  +A                        +S+
Sbjct: 1969 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2006

Query: 4008 QIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKL 4067
             I+++  L+                N +N  + ++ +D+++E  +N   +L         
Sbjct: 2007 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2041

Query: 4068 KDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEF 4127
              +   E+  D     R L + +  +     +K +   E++F       ++ E  N E+ 
Sbjct: 2042 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-------EDGE--NGEDG 2090

Query: 4128 ANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLEL-----AESILEYFRPYLGRIEI 4182
            A       R++G N+ +L   L+    H+  L + L+       +  LE++  +  +IEI
Sbjct: 2091 A----ASPRNVGHNIYILAHQLAR---HNKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2143

Query: 4183 MGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIF 4242
            +   R +E+I F +             KESK + I+       +  K+  F    ED   
Sbjct: 2144 VRLDRTMEQIVFPVPSICEF-----LTKESKLR-IYYTTERDEQGSKINDFFLRSEDLFN 2197

Query: 4243 EM 4244
            EM
Sbjct: 2198 EM 2199



 Score = 43.9 bits (102), Expect = 0.004
 Identities = 38/175 (21%), Positives = 81/175 (46%), Gaps = 24/175 (13%)

Query: 461  EEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAES-WKEIVN 519
            +E  S  +S + +Q L +  G  ++VL  +             +   E+A ++  +EI+ 
Sbjct: 1175 QESASVRKSRKQQQRLLRNMGAHAVVLELL-------------QIPYEKAEDTKMQEIMR 1221

Query: 520  LLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYC--VLIESPEVLNII 577
            L +E L +   GN+ N AL   +++        L  + GILE +    + + + ++ + I
Sbjct: 1222 LAHEFLQNFCAGNQQNQALLHKHIN--------LFLNPGILEAVTMQHIFMNNFQLCSEI 1273

Query: 578  QENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLL 632
             E  ++  +  ++ HGRN + +  L ++    G  ++  QD++   L+   E +L
Sbjct: 1274 NERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVL 1328


>gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo
            sapiens]
          Length = 2671

 Score =  161 bits (407), Expect = 2e-38
 Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 51/288 (17%)

Query: 4787 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4845
            D  FLY   Y++ S+LG + +  F++  L D+    +TL  ++ SVT NG+ +++T  L 
Sbjct: 2317 DMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLA 2376

Query: 4846 AVVVYLYTVVAFNFFRKFY----------------------------------------- 4864
             ++VYL+++V F F +  +                                         
Sbjct: 2377 LILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGL 2436

Query: 4865 ------NKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELY--RVV 4916
                   +  + D  +  CD ++ C +  M  G+R GGG+GD +  P+ DE  L+  RVV
Sbjct: 2437 SVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDE-SLFPARVV 2495

Query: 4917 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGF 4976
            +D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+  D FD     F
Sbjct: 2496 YDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSF 2555

Query: 4977 ETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
            E H   EHN+ NY++F++ +  K++T++TG ESYV +M + +  D+FP
Sbjct: 2556 EEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFP 2603



 Score = 88.2 bits (217), Expect = 2e-16
 Identities = 137/589 (23%), Positives = 233/589 (39%), Gaps = 90/589 (15%)

Query: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATG-EACWWTMHPASKQRSEGE 160
           YG  I L H  S  YL+      ++ +K A  V L  DATG E  W  + P  K RS G+
Sbjct: 118 YGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTL--DATGNEGSWLFIQPFWKLRSNGD 175

Query: 161 KVRVGDDIILVSVSSERYLH-----LSTASGELQVDASFMQTLWNMNPICSRCE--EGFV 213
            V VGD +IL  V++ + LH     LS  +G  +V++    T W +N      +  E  +
Sbjct: 176 NVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235

Query: 214 TGGHVLRLFHGHMDECLTISPADSDDQ--RRLVYYEGGAVCTHARSLWRLEPLRIS-WSG 270
            GG V+RLFH   ++ LT        Q   R    +     T + +LW +E +      G
Sbjct: 236 KGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRG 295

Query: 271 SHLRWGQPLRVRHVTTGQYLALTEDQGLVVVDASKAHT---------------KATSFCF 315
               W    R +H+ TG YLA  E+      DAS                   +   +C 
Sbjct: 296 GAGHWNGLYRFKHLATGNYLA-AEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCL 354

Query: 316 RISKEKLDVAPKRDVEGMGPPEIKYGESLC------FVQHVASGLWL--TYAAPD----- 362
                  D+A   +++   P  ++  +S         ++H+ +  W+  T    D     
Sbjct: 355 VAVPHGNDIASLFELD---PTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEER 411

Query: 363 PKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQ-FIKSLDSFS 421
           P  L LG    K        +   +S  R     + A+ M+ S     N+ FI   D   
Sbjct: 412 PIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDR-- 469

Query: 422 GKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEG 481
                             VI  L+DL+ +      + Q+       +  R RQ L +E+ 
Sbjct: 470 ----------------RFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQN 513

Query: 482 MLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNL-------LYELLASLIRGNRS 534
           +L  V   +         A F E  GE      +E+ +        ++ L   ++R ++ 
Sbjct: 514 ILKQVFGILK--------APFREKGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQE 565

Query: 535 NCALFSTNLDWLVSKLDRLEASSG---ILEVLYCVLIESPEVL--NIIQENHIKSIISLL 589
           +   +  N + +  +   +++  G   + E     L+ +   L    I +  +++ +SL+
Sbjct: 566 D---YRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLV 622

Query: 590 DKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGR--ELLLQTNL 636
            K+ R  + LD L  LCV N +A+   Q+LI + +L  +  ++L++T L
Sbjct: 623 RKN-REPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTEL 670



 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 68/247 (27%), Positives = 108/247 (43%), Gaps = 51/247 (20%)

Query: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3824
            Q RL   GA ++V  +I++ K E   +   ++ L I +L+GGN E+Q+   + +  DKK 
Sbjct: 1725 QCRLDKEGATKLVCDLITSTKNEK--IFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKS 1782

Query: 3825 VGFFQSI-----QALMQTCSVLDLNAFERQNKAE--------------------GLGMVN 3859
              FF+ +     +A  +T S + +N  +  ++                      G     
Sbjct: 1783 ERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRY 1842

Query: 3860 EDGTVINRQN--GEKVMADDEFT-----QDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTI 3912
              G  + R +   E+V + +  T     Q + RFLQLLCE HN D QN+LR Q  N T  
Sbjct: 1843 SLGPSLRRGHEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NNKTNY 1901

Query: 3913 NIIICTVDYLLRLQESIS---DFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQ 3969
            N++  T+ +L  +  S +        Y  +D +             +  Q   +LTEY Q
Sbjct: 1902 NLVCETLQFLDIMCGSTTGGLGLLGLYINEDNV------------GLVIQTLETLTEYCQ 1949

Query: 3970 GPCTGNQ 3976
            GPC  NQ
Sbjct: 1950 GPCHENQ 1956



 Score = 37.7 bits (86), Expect = 0.29
 Identities = 29/109 (26%), Positives = 51/109 (46%), Gaps = 6/109 (5%)

Query: 516  EIVNLLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLN 575
            EI+   ++ L     GN  N AL   +L   ++    LEA     E +  + + + ++ +
Sbjct: 1223 EILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTP-GLLEA-----ETMQHIFLNNYQLCS 1276

Query: 576  IIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENL 624
             I E  ++  + LL  HGR+ + LD L ++    G  V+  QD+I   L
Sbjct: 1277 EISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTEL 1325


>gi|17975763 myelin transcription factor 1 [Homo sapiens]
          Length = 1121

 Score = 78.2 bits (191), Expect = 2e-13
 Identities = 55/148 (37%), Positives = 75/148 (50%), Gaps = 16/148 (10%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQ---- 1928
            EE+EEE+EEEE EEEDEEE+EE+EEE  +E+E+EE+EEEE  E E+EE   + + Q    
Sbjct: 259  EEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTS 318

Query: 1929 ----MKLPE-------SVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRY 1977
                 K PE       S K +   ++E   D +      S  +      +      R   
Sbjct: 319  HTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNL 378

Query: 1978 GLLIKAFSMTAAETARRTREFRSPPQEQ 2005
            GLL +A ++  AE  R   E   PP EQ
Sbjct: 379  GLLEQAIAL-KAEQVRTVCEPGCPPAEQ 405



 Score = 58.2 bits (139), Expect = 2e-07
 Identities = 30/61 (49%), Positives = 41/61 (67%), Gaps = 4/61 (6%)

Query: 1868 PEVFTEEEEEEDEEEEG----EEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLE 1923
            P+   +   EE  +++G    EEEDEEE+EE+EEE   E+E+EE+EEEE  E E+EE  E
Sbjct: 237  PQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEE 296

Query: 1924 E 1924
            E
Sbjct: 297  E 297



 Score = 38.1 bits (87), Expect = 0.22
 Identities = 40/131 (30%), Positives = 54/131 (41%), Gaps = 13/131 (9%)

Query: 4405 GEGASEGAG------DAAEGAGDEE-EAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDM 4457
            G+ A  G G      +AAEGA  EE E      P  A+  V VT       E +  L   
Sbjct: 185  GQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTT------ERSQDLCPQ 238

Query: 4458 GDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEP 4517
                 A   + +   IL  +   +  EEE   E E E E E E E+ + E  E+EE  E 
Sbjct: 239  SLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEE 298

Query: 4518 TPEPPKKQAPP 4528
              E  +++A P
Sbjct: 299  EEEEEEEEAAP 309



 Score = 37.0 bits (84), Expect = 0.50
 Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 6/68 (8%)

Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG 1916
            ED ++++++      T E  ++   +  E+   EE  + +   + E+EDEE+EEEE  E 
Sbjct: 219  EDAEEVVEV------TTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEE 272

Query: 1917 EKEEGLEE 1924
            E EE  EE
Sbjct: 273  EDEEEEEE 280



 Score = 34.3 bits (77), Expect = 3.2
 Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 14/66 (21%)

Query: 4484 EEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPE--------------PPKKQAPPS 4529
            +EE   E E E E E E E+ + E  E+EE  E  P+               P+ + P S
Sbjct: 274  DEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPES 333

Query: 4530 PPPKKE 4535
            P PK E
Sbjct: 334  PSPKPE 339


>gi|37588869 ring finger protein 123 [Homo sapiens]
          Length = 1314

 Score = 70.9 bits (172), Expect = 3e-11
 Identities = 39/127 (30%), Positives = 65/127 (51%), Gaps = 10/127 (7%)

Query: 1082 VQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADEL--AYVFNGHRGQRWHLGSEPFG 1139
            V  G+W +E    + G M++GW     R + E G  +   +Y ++G+R ++W++ +  +G
Sbjct: 130  VYKGKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYG 189

Query: 1140 RPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIE--IGDGFLPVCSLGPGQ 1197
            + W  GD+V C+IDL + T+ F LNG  L       TAF  +   +G  + P  SL   +
Sbjct: 190  KAWAAGDIVSCLIDLDDGTLSFCLNGVSL------GTAFENLSRGLGMAYFPAISLSFKE 243

Query: 1198 VGHLNLG 1204
                N G
Sbjct: 244  SVAFNFG 250



 Score = 49.3 bits (116), Expect = 1e-04
 Identities = 36/110 (32%), Positives = 54/110 (49%), Gaps = 8/110 (7%)

Query: 705 GVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQ 764
           GVGD   SY +DG  +   +V    T+ G+   A  D++SC +DL   ++SF +NG  + 
Sbjct: 163 GVGDTHNSYAYDGNRVRKWNVT--TTNYGK-AWAAGDIVSCLIDLDDGTLSFCLNGVSLG 219

Query: 765 GVFESFN--LDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHE 812
             FE+ +  L   +FP +S S    V F  G R   +   P  GY P  +
Sbjct: 220 TAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRY---PVAGYRPLQD 266


>gi|45387949 ring finger and SPRY domain containing 1 [Homo sapiens]
          Length = 576

 Score = 68.6 bits (166), Expect = 2e-10
 Identities = 38/110 (34%), Positives = 59/110 (53%), Gaps = 6/110 (5%)

Query: 1065 QSRCDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELR----PDVELGADELA 1120
            ++RCD         ++ V +G WY+E   VT+G M++GWA  + +        +G DE +
Sbjct: 339  EARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYS 398

Query: 1121 YVFNGHRGQRWH-LGSEPFGRP-WQPGDVVGCMIDLTENTIIFTLNGEVL 1168
              ++G R   W+   S+P   P W+ GD VG ++DL E  +IF LNG  L
Sbjct: 399  CAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQL 448



 Score = 40.8 bits (94), Expect = 0.034
 Identities = 45/173 (26%), Positives = 71/173 (41%), Gaps = 35/173 (20%)

Query: 661 WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLH- 719
           WY+EV V          +  +++GWA  +             G G+GDD YS  +DG   
Sbjct: 361 WYYEVTV--------VTSGVMQIGWATRDSKFL------NHEGYGIGDDEYSCAYDGCRQ 406

Query: 720 -LWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRING---CPVQGVFESFNLDGL 775
            +W    ++P   P        D +   LDL+   + F +NG    P + VF S  + G 
Sbjct: 407 LIWYNARSKPHIHP---CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSS-TVSG- 461

Query: 776 FFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHE---------AVLPRER 819
           FF   SF +  +  F  G +   FK+ P   ++  ++          +LPR R
Sbjct: 462 FFAAASFMSYQQCEFNFGAK--PFKYPPSMKFSTFNDYAFLTAEEKIILPRHR 512


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 43/80 (53%), Positives = 54/80 (67%), Gaps = 3/80 (3%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG-LEEG 1925
            E E   EEEEEE+EEEE EEED EE+EEDEEE  +E+E+EE+E EE  E E+EEG LEE 
Sbjct: 888  EEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEE--EFEEEEGELEEE 945

Query: 1926 LLQMKLPESVKLQMCHLLEY 1945
              +    E  +L+    LE+
Sbjct: 946  EEEEDEEEEEELEEVEDLEF 965



 Score = 64.7 bits (156), Expect = 2e-09
 Identities = 37/74 (50%), Positives = 49/74 (66%)

Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
            G   +++ L +I      EEEEEE+EEEE EEE+EEE+E+ EEE   E+E  E+EEEE  
Sbjct: 870  GPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEE 929

Query: 1915 EGEKEEGLEEGLLQ 1928
            E E+E   EEG L+
Sbjct: 930  EFEEEFEEEEGELE 943



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 40/86 (46%), Positives = 55/86 (63%), Gaps = 5/86 (5%)

Query: 1844 LVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDE--EEKEEDEEETAQ 1901
            L   L V+ I   ++ ++  +  E E   EEEEEED EEE E+E+E  EE+EE+EEE  +
Sbjct: 874  LEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEE 933

Query: 1902 EKEDEE---KEEEEAAEGEKEEGLEE 1924
            E E+EE   +EEEE  + E+EE LEE
Sbjct: 934  EFEEEEGELEEEEEEEDEEEEEELEE 959



 Score = 60.1 bits (144), Expect = 5e-08
 Identities = 34/61 (55%), Positives = 44/61 (72%), Gaps = 2/61 (3%)

Query: 1867 EPEVFTEEEEEEDE--EEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            E E F EEEE+E+E  EEE EEE+E E+E +EEE   E+E+EE++EEE  E E+ E LE 
Sbjct: 906  EEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEF 965

Query: 1925 G 1925
            G
Sbjct: 966  G 966



 Score = 56.2 bits (134), Expect = 8e-07
 Identities = 32/59 (54%), Positives = 40/59 (67%), Gaps = 4/59 (6%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEE----AAEGEKEEG 1921
            E E F EEEEEE+E EE  EE+E E EE+EEE  +E+E+E +E E+     A GE EEG
Sbjct: 917  EEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEG 975



 Score = 42.4 bits (98), Expect = 0.012
 Identities = 38/132 (28%), Positives = 53/132 (40%), Gaps = 8/132 (6%)

Query: 4410 EGAGDAAEGAGDEEEA-----VHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAE 4464
            EG  +  E   DEEE      V +   G A G V   +G P  P     L    ++ P  
Sbjct: 939  EGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVE--EGAPPPPTLPPALPPP-ESPPKV 995

Query: 4465 PPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEPPKK 4524
             P PE  P L  ++   G EEE   +  P   PE  P + + E   +     P P+   +
Sbjct: 996  QPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVE 1055

Query: 4525 QAPPSPPPKKEE 4536
            + P +PP   EE
Sbjct: 1056 EEPSAPPTLLEE 1067



 Score = 35.0 bits (79), Expect = 1.9
 Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 8/93 (8%)

Query: 3670 EDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIM 3729
            ED  + +++ + E+EEEEEE EE++ +   +           E+ + +E+Y      +  
Sbjct: 876  EDLTVININSSDEEEEEEEEEEEEEEEEEEE------EEDFEEEEEDEEEYFEEEEEEEE 929

Query: 3730 AKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRL 3762
                  EE  E GE EEE E   EE++ E + +
Sbjct: 930  EFEEEFEE--EEGELEEEEEEEDEEEEEELEEV 960



 Score = 33.1 bits (74), Expect = 7.2
 Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDE 1906
            +E+ ++  +  E E    EEEEE+E+EE EEE+ EE E+ E  TA  + +E
Sbjct: 925  EEEEEEFEEEFEEEEGELEEEEEEEDEE-EEEELEEVEDLEFGTAGGEVEE 974



 Score = 33.1 bits (74), Expect = 7.2
 Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 1/66 (1%)

Query: 4484 EEELPPEPEPEPEPELEPEKADAENGEKEE-VPEPTPEPPKKQAPPSPPPKKEEAGGEFW 4542
            EEE   E E E   E+E  +     GE EE  P P   PP    P SPP  + E   E  
Sbjct: 945  EEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPG 1004

Query: 4543 GELEVQ 4548
              LEV+
Sbjct: 1005 LLLEVE 1010


>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
          Length = 1321

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 30/52 (57%), Positives = 44/52 (84%)

Query: 1863 LKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
            L  ++P+   +EEEEE+EE+E EEE++EE+EE+EEE  +E+E+EE+EEEEAA
Sbjct: 722  LAPVQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAA 773



 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 30/42 (71%), Positives = 38/42 (90%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
            EEEEEE+E+EE EEEDEEE+EE+EEE  +E+E+EE+EEE AA
Sbjct: 733  EEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAA 774



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 31/86 (36%), Positives = 42/86 (48%), Gaps = 6/86 (6%)

Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEE------ETAQEKEDEEK 1908
            G E+ ++  +  E E   EEEEEE+EEEE EEE+EEE+EE+        E    +     
Sbjct: 731  GKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGEVLGPRSGSSS 790

Query: 1909 EEEEAAEGEKEEGLEEGLLQMKLPES 1934
            E  E +    +EG    LL     ES
Sbjct: 791  EGSERSTDRSQEGAPSTLLADDQKES 816


>gi|169210053 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 185

 Score = 66.2 bits (160), Expect = 8e-10
 Identities = 36/54 (66%), Positives = 41/54 (75%), Gaps = 2/54 (3%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEK--EEGLEE 1924
            EEE EE+EEE  EEE EEEKEEDEEE  +E+E EE EEEE  EG+K  EE +EE
Sbjct: 120  EEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEE 173



 Score = 59.7 bits (143), Expect = 7e-08
 Identities = 30/64 (46%), Positives = 47/64 (73%)

Query: 1860 KQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKE 1919
            +Q L + E EV  EEEE E+EE+E E+E++EE+EE EEE  +++E+EEKE ++  E + E
Sbjct: 113  QQGLPVEEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVE 172

Query: 1920 EGLE 1923
            E ++
Sbjct: 173  EEID 176



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 29/67 (43%), Positives = 48/67 (71%), Gaps = 1/67 (1%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            +E+V++  + +E E   EEE+EEDEEEE +EE++EE EE+EE+  ++ E+E+ EEE   E
Sbjct: 120  EEEVEEEEEEVEEEE-KEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEEEIDTE 178

Query: 1916 GEKEEGL 1922
             ++ + L
Sbjct: 179  IQRTQYL 185



 Score = 49.7 bits (117), Expect = 7e-05
 Identities = 30/65 (46%), Positives = 40/65 (61%), Gaps = 3/65 (4%)

Query: 1877 EEDEEEEG---EEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPE 1933
            EE   ++G   EEE+ EE+EE+ EE  +E+E EE EEEE  E EKEE  EE   + K  E
Sbjct: 108  EECSAQQGLPVEEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKME 167

Query: 1934 SVKLQ 1938
              K++
Sbjct: 168  EEKVE 172



 Score = 35.0 bits (79), Expect = 1.9
 Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 6/76 (7%)

Query: 4479 GVDGVEEELPPEPEPEPEPELEPEKA-DAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEA 4537
            G+   EEE+  E E   E E E EK  D E  EKEE  E   E  +K+       K EE 
Sbjct: 115  GLPVEEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEEE 174

Query: 4538 GGEFWGELEVQRVKFL 4553
                  + E+QR ++L
Sbjct: 175  I-----DTEIQRTQYL 185


>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
          Length = 587

 Score = 62.4 bits (150), Expect = 1e-08
 Identities = 33/74 (44%), Positives = 50/74 (67%), Gaps = 6/74 (8%)

Query: 1851 MGIFGDEDVKQIL------KMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKE 1904
            +G  G E ++++L      K++      E+EEEE+E EE EEE EEE+EEDEEE  +E+E
Sbjct: 333  LGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEE 392

Query: 1905 DEEKEEEEAAEGEK 1918
            +EE+E ++  +GEK
Sbjct: 393  EEEEEPQQRGQGEK 406



 Score = 58.5 bits (140), Expect = 2e-07
 Identities = 29/71 (40%), Positives = 48/71 (67%), Gaps = 4/71 (5%)

Query: 1855 GDEDVKQILKMIE----PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
            G+E  +Q+ +++E     +V     ++EDEEEE E E+EEE+ E+EEE  +E+E+EE+EE
Sbjct: 334  GEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEE 393

Query: 1911 EEAAEGEKEEG 1921
            EE    ++ +G
Sbjct: 394  EEEEPQQRGQG 404



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 25/62 (40%), Positives = 36/62 (58%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            DED ++  +  E E   EEEEEEDEEEE EEE+EEE+E  +    ++     ++  +   
Sbjct: 360  DEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNT 419

Query: 1916 GE 1917
            GE
Sbjct: 420  GE 421


>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
          Length = 675

 Score = 62.4 bits (150), Expect = 1e-08
 Identities = 63/249 (25%), Positives = 111/249 (44%), Gaps = 17/249 (6%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            D+D  ++ K I  E  T  + E + EE  +++ EEEK   EEE   + E E++E E+  +
Sbjct: 354  DDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQ 413

Query: 1916 --GEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQ 1973
              GE+EE  E   L  +  E +KL+    ++    + L+ + E +   +E+ + K    +
Sbjct: 414  EMGEEEEENETFGLSREYEELIKLKRSGSIQ---AKNLKSKFEKIGQLSEKEIQKKIEEE 470

Query: 1974 RSRYGLLIKAFSMTAAET--------ARRTREFRSPPQEQINMLLQFKD---GTDEEDCP 2022
            R+R   +        AE          R  R+  +P   ++NM  +F+      +EE+  
Sbjct: 471  RARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQR 530

Query: 2023 LPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEE 2082
              EE +   + F Q  +    +Q   EEEE EE + +        E+ R      +KP +
Sbjct: 531  RIEEQKLLRMQFEQREI-DAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLK 589

Query: 2083 ERSAEESKP 2091
              S  +S+P
Sbjct: 590  NTSVVDSEP 598



 Score = 41.2 bits (95), Expect = 0.026
 Identities = 59/243 (24%), Positives = 104/243 (42%), Gaps = 37/243 (15%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLP 1932
            +E  ++  EEE  +  EEEK   EE   Q   ++E+ ++ A   +  +G   G L++   
Sbjct: 259  QENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTA---KIFKGYRPGKLKLSF- 314

Query: 1933 ESVKLQMCHLLEYFCDQELQHRV-ESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAET 1991
            E ++ Q     +   ++E + R+ E   AFAE           +R  +++   S    +T
Sbjct: 315  EEMERQRREDEKRKAEEEARRRIEEEKKAFAE-----------ARRNMVVDDDSPEMYKT 363

Query: 1992 ARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEE 2051
               ++EF +P + +IN     K   +EE     EE R+  L+  +        ++  EEE
Sbjct: 364  I--SQEFLTPGKLEINFEELLKQKMEEEKRRTEEE-RKHKLEMEKQEFEQLRQEMGEEEE 420

Query: 2052 EPE--------EE--------TTLGSRLMSLLEKVRLVKKKE--EKPEEERSAEESKPRS 2093
            E E        EE        +     L S  EK+  + +KE  +K EEER+   +    
Sbjct: 421  ENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLE 480

Query: 2094 LQE 2096
            ++E
Sbjct: 481  IKE 483



 Score = 33.5 bits (75), Expect = 5.5
 Identities = 60/284 (21%), Positives = 109/284 (38%), Gaps = 22/284 (7%)

Query: 1828 DPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEE 1887
            + V   VE  +VP  KL  T  V G F + +     K  + E   + +  E+E +   E+
Sbjct: 84   EDVSSKVEKAYVP--KLTGT--VKGRFAEME-----KQRQEE---QRKRTEEERKRRIEQ 131

Query: 1888 DEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFC 1947
            D  EK + + E A+  E  E       E   EEG ++ LL   +P         + + F 
Sbjct: 132  DMLEKRKIQRELAKRAEQIEDINNTGTESASEEG-DDSLLITVVPVKSYKTSGKMKKNFE 190

Query: 1948 DQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQIN 2007
            D E +   +    + E    + +  + S       +  M     +   +E  SP + ++ 
Sbjct: 191  DLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLT 250

Query: 2008 MLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTL------GS 2061
                 +   +       EE R+  L+  +        Q+  E+EE ++   +      G 
Sbjct: 251  FEELERQRQENRKKQAEEEARK-RLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309

Query: 2062 RLMSL--LEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMVV 2103
              +S   +E+ R   +K +  EE R   E + ++  E   +MVV
Sbjct: 310  LKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVV 353


>gi|189409130 zinc finger E-box binding homeobox 1 isoform a [Homo
            sapiens]
          Length = 1108

 Score = 60.5 bits (145), Expect = 4e-08
 Identities = 37/81 (45%), Positives = 49/81 (60%), Gaps = 1/81 (1%)

Query: 1855 GDEDVKQILKMIEPEVFT-EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEA 1913
            GD D ++ L   E E    EEEEE+ E EE +EE E EK + +EE  +E+E+ E+EE E 
Sbjct: 1004 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE 1063

Query: 1914 AEGEKEEGLEEGLLQMKLPES 1934
            AE E EE   EGL++    ES
Sbjct: 1064 AENEGEEAKTEGLMKDDRAES 1084



 Score = 42.7 bits (99), Expect = 0.009
 Identities = 22/63 (34%), Positives = 39/63 (61%)

Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKL 1931
            ++ + +E E    EE+++ EKEE+EE+   E+  EEKE E+    E+EE  EE + + ++
Sbjct: 1002 SQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEV 1061

Query: 1932 PES 1934
             E+
Sbjct: 1062 EEA 1064



 Score = 42.4 bits (98), Expect = 0.012
 Identities = 23/62 (37%), Positives = 36/62 (58%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLP 1932
            EEEEEE+EE E EE +E E E +E +T    +D+  E + ++ G+K     E + + K  
Sbjct: 1047 EEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTN 1106

Query: 1933 ES 1934
            E+
Sbjct: 1107 EA 1108



 Score = 36.2 bits (82), Expect = 0.85
 Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 4/57 (7%)

Query: 1872 TEEEEEEDE----EEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            TE+EE   E    E  G      + + DE E+   +EDE+ E+EE  E ++ E L+E
Sbjct: 980  TEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQE 1036



 Score = 34.3 bits (77), Expect = 3.2
 Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 5/62 (8%)

Query: 1868 PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEE-----EAAEGEKEEGL 1922
            PE+ + E           + DE E    EE+   EKE+EE+++E     E  E EK +G 
Sbjct: 987  PEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGD 1046

Query: 1923 EE 1924
            EE
Sbjct: 1047 EE 1048


>gi|189409128 zinc finger E-box binding homeobox 1 isoform b [Homo
            sapiens]
          Length = 1124

 Score = 60.5 bits (145), Expect = 4e-08
 Identities = 37/81 (45%), Positives = 49/81 (60%), Gaps = 1/81 (1%)

Query: 1855 GDEDVKQILKMIEPEVFT-EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEA 1913
            GD D ++ L   E E    EEEEE+ E EE +EE E EK + +EE  +E+E+ E+EE E 
Sbjct: 1020 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE 1079

Query: 1914 AEGEKEEGLEEGLLQMKLPES 1934
            AE E EE   EGL++    ES
Sbjct: 1080 AENEGEEAKTEGLMKDDRAES 1100



 Score = 42.7 bits (99), Expect = 0.009
 Identities = 22/63 (34%), Positives = 39/63 (61%)

Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKL 1931
            ++ + +E E    EE+++ EKEE+EE+   E+  EEKE E+    E+EE  EE + + ++
Sbjct: 1018 SQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEV 1077

Query: 1932 PES 1934
             E+
Sbjct: 1078 EEA 1080



 Score = 42.4 bits (98), Expect = 0.012
 Identities = 23/62 (37%), Positives = 36/62 (58%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLP 1932
            EEEEEE+EE E EE +E E E +E +T    +D+  E + ++ G+K     E + + K  
Sbjct: 1063 EEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTN 1122

Query: 1933 ES 1934
            E+
Sbjct: 1123 EA 1124



 Score = 36.2 bits (82), Expect = 0.85
 Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 4/57 (7%)

Query: 1872 TEEEEEEDE----EEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            TE+EE   E    E  G      + + DE E+   +EDE+ E+EE  E ++ E L+E
Sbjct: 996  TEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQE 1052



 Score = 34.3 bits (77), Expect = 3.2
 Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 5/62 (8%)

Query: 1868 PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEE-----EAAEGEKEEGL 1922
            PE+ + E           + DE E    EE+   EKE+EE+++E     E  E EK +G 
Sbjct: 1003 PEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGD 1062

Query: 1923 EE 1924
            EE
Sbjct: 1063 EE 1064


>gi|22749303 hypothetical protein LOC196477 [Homo sapiens]
          Length = 406

 Score = 60.5 bits (145), Expect = 4e-08
 Identities = 36/69 (52%), Positives = 45/69 (65%), Gaps = 2/69 (2%)

Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDE--EETAQEKEDEEKEEEEAAEGEKEEGLEEGL 1926
            E   EEEE EDEEEE E+E+EEE EE E  EE  +E E+EE EEEE    E E+  EE  
Sbjct: 299  EASEEEEEVEDEEEEVEDEEEEEVEEAEYVEEGEEELEEEELEEEEEVLEENEQRGEEFH 358

Query: 1927 LQMKLPESV 1935
            L +++P S+
Sbjct: 359  LPLEMPLSI 367



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 61/201 (30%), Positives = 86/201 (42%), Gaps = 28/201 (13%)

Query: 1748 PPGRSTENG--------HPRHGLPG---VGVTTSLRP--------PHHFSPPCFVAALPA 1788
            PPGR    G        HPRH  P      V+T  RP        P   +PP     +  
Sbjct: 136  PPGRKKRWGRRGRGLRHHPRHSYPRSPPADVSTLPRPVKLYEWREPGMRAPPNTTQFIMN 195

Query: 1789 AGAAEAPARLSPAIPLEALRDKALRMLGEA--VRDGGQHARDPVGGSVEFQFVP--VLKL 1844
                +   +       EALR +   + GEA   R  G  A  P GGS E   +   +   
Sbjct: 196  QIYEDMRQQEKVERQQEALRAQKATVSGEASPARSSGNDA--PPGGSKETWGLQETLYGF 253

Query: 1845 VSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKE 1904
            V    +      E+ + +  ++  E   EEE++ D+EEE ++E  + KE  EEE   E E
Sbjct: 254  VQNPSLAFSPNPEENQSLAPLLVEE---EEEKKNDDEEEYDQEVCDAKEASEEEEEVEDE 310

Query: 1905 DEEKEEEEAAEGEKEEGLEEG 1925
            +EE E+EE  E E+ E +EEG
Sbjct: 311  EEEVEDEEEEEVEEAEYVEEG 331


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 59.7 bits (143), Expect = 7e-08
 Identities = 49/171 (28%), Positives = 84/171 (49%), Gaps = 6/171 (3%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            +E+ ++  +  E E   EEEEE  EEEEGEE+  E++EE++++  +EK+ EE +E+E   
Sbjct: 2247 EEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVF 2306

Query: 1916 GEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRS 1975
             EKEE + E   +    E  + + C L E    ++   + E      E+    L+  +R 
Sbjct: 2307 EEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERV 2366

Query: 1976 RYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEE 2026
               L I          A R    +SP ++ ++  L+ K+ T     P+PE+
Sbjct: 2367 ---LSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKT---PVPVPEK 2411



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 36/99 (36%), Positives = 51/99 (51%), Gaps = 7/99 (7%)

Query: 1831 GGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEP----EVFTEEEEEE-DEEEEGE 1885
            GG  E + +P LK           GD+  ++    ++     E F+EE E   DE E+ E
Sbjct: 2182 GGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQE 2241

Query: 1886 EEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
                EE+EE EEE  +E+E+EE  EEE    E+EEG E+
Sbjct: 2242 SLSSEEEEEREEE--EEREEEEVREEEEERKEEEEGEEK 2278



 Score = 42.7 bits (99), Expect = 0.009
 Identities = 66/279 (23%), Positives = 118/279 (42%), Gaps = 60/279 (21%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEET----------AQEKEDEE-----KEEE 1911
            E EV  EEE   + EE+ ++  EE++   EE            A++K  +E     +EEE
Sbjct: 1541 EEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEE 1600

Query: 1912 EAAEGEKEEGLEEGLL---QMKLPESVKLQMCHLLEYFCDQE--LQHRVESLAAFAERYV 1966
            + A+ E++   EE  L    +K+ +  + +M      F  +E  L  R E L+  AE+  
Sbjct: 1601 KLAQEERQLAQEERKLAQAYVKITQDDR-EMAQAEGKFAQKEETLAQRGEKLSQEAEKLA 1659

Query: 1967 DKLQANQRSRYGLLIKAFSMTAAETAR------RTREFRSPPQEQINMLLQFKDGTDEED 2020
             K +         L K +   A E  +      +  E ++   +++  L Q +   D ++
Sbjct: 1660 QKRKK--------LAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQE 1711

Query: 2021 CPLPEEIRQDLLDFHQDLLAHCGIQLD-------------GEEEE---------PEEETT 2058
              L +E+ +  L++  + L+    +L+              EEEE          EEET 
Sbjct: 1712 KELAQELEE--LEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETK 1769

Query: 2059 LGSRLMSLL-EKVRLVKKKEEKPEEERSAEESKPRSLQE 2096
            L      L+ EK +L + KE+ PEEE      + + +++
Sbjct: 1770 LAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEK 1808



 Score = 38.1 bits (87), Expect = 0.22
 Identities = 35/150 (23%), Positives = 66/150 (44%)

Query: 3665 EDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMA 3724
            E+   E+ + ++  +  E+EE EE+  EK+ +   +      +  + EK ++ E+   + 
Sbjct: 2254 EEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIM 2313

Query: 3725 YADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQMISA 3784
              +        EE  E+   EEEV+   E  + EKQ  L +Q R   RG   ++  +   
Sbjct: 2314 SEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGV 2373

Query: 3785 CKGETGAMVSSTLKLGISILNGGNAEVQQK 3814
              G+  A+    LK  +  L     E+++K
Sbjct: 2374 PHGKGRAIRLGVLKSPLKKLMSTALEMKEK 2403



 Score = 36.6 bits (83), Expect = 0.65
 Identities = 64/278 (23%), Positives = 115/278 (41%), Gaps = 49/278 (17%)

Query: 1856 DEDVKQILKMIEPEVFTEEE----EEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEE 1911
            D   K++ + +E   +  EE    EEE  +EEG+  +E++K  +EEE    + ++  EEE
Sbjct: 1708 DWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEE 1767

Query: 1912 EAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQA 1971
                 E     EE L+Q K                         E LA   E+  ++ + 
Sbjct: 1768 TKLAQE-----EELLIQEK-------------------------EKLAQHKEKMPEEEER 1797

Query: 1972 NQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQIN-MLLQFKDGTDEEDCPLPEE---- 2026
              R R  L+ K   +      +R R   S  +   N M+L  K    +E   L +E    
Sbjct: 1798 LGRKREQLIEKKMKL----AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKL 1853

Query: 2027 -IRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLL--EKVRLVKKKEEKPEEE 2083
              R++ L ++++ L H   QL   + +      + +++   L  EK  ++KKKE+  E E
Sbjct: 1854 AQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETE 1913

Query: 2084 R---SAEESKPRSLQELVSHMVVRWAQEDFVQSPELVR 2118
            +     E+S  +  ++L    +    ++  VQ  + +R
Sbjct: 1914 KKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLR 1951



 Score = 35.0 bits (79), Expect = 1.9
 Identities = 48/224 (21%), Positives = 98/224 (43%), Gaps = 22/224 (9%)

Query: 1864 KMIEPEVFTEEEEEEDEEEEGEE--EDEEEKEEDEEETAQEKEDEEKEEEEAAEGEK-EE 1920
            +MI  E    EEE +   +  E   +DEEE   +EEE     +   ++ +EA  G+K +E
Sbjct: 2152 RMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKE 2211

Query: 1921 GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL 1980
                 + +++  E    +M  LL+     EL+ + ESL++  E   ++ +  +       
Sbjct: 2212 KFSSQVDEVESEEHFSEEMESLLD-----ELE-KQESLSSEEEEEREEEEEREEEE---- 2261

Query: 1981 IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA 2040
                     E     +E     ++Q+    + K    +E      + ++++ +  +++++
Sbjct: 2262 -------VREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMS 2314

Query: 2041 HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEER 2084
                +   +EEE EE  +L   +    EK  L K+K+ K +E+R
Sbjct: 2315 EEETESLSDEEEEEESCSLEEEVDR--EKEILKKEKQFKLQEQR 2356


>gi|4508005 tripartite motif-containing 26 [Homo sapiens]
          Length = 539

 Score = 59.3 bits (142), Expect = 9e-08
 Identities = 31/62 (50%), Positives = 41/62 (66%), Gaps = 12/62 (19%)

Query: 1866 IEPEVFTEEEEEEDEEEEGEEEDEEEK------------EEDEEETAQEKEDEEKEEEEA 1913
            +E E ++E+EEE DEEEEGEEE+EEE+            +EDEE    E+E+EE+EEEE 
Sbjct: 374  VEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESLGDEEEEEEEEEEEV 433

Query: 1914 AE 1915
             E
Sbjct: 434  LE 435



 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 30/65 (46%), Positives = 39/65 (60%), Gaps = 10/65 (15%)

Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETA--------QEKEDEEK--EEEEAAEGEK 1918
            EV  E E   ++EEEG+EE+E E+EE+EEE          +  EDEE   +EEE  E E+
Sbjct: 371  EVEVEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESLGDEEEEEEEEE 430

Query: 1919 EEGLE 1923
            EE LE
Sbjct: 431  EEVLE 435



 Score = 41.6 bits (96), Expect = 0.020
 Identities = 24/62 (38%), Positives = 37/62 (59%), Gaps = 6/62 (9%)

Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEK------EDEEKEEEEAAEGEKEEGL 1922
            +V+ E E E +   E EEE +EE+E +EEE  +E       +D E +E+E + G++EE  
Sbjct: 367  KVYWEVEVEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESLGDEEEEE 426

Query: 1923 EE 1924
            EE
Sbjct: 427  EE 428


>gi|21735569 claspin [Homo sapiens]
          Length = 1339

 Score = 58.5 bits (140), Expect = 2e-07
 Identities = 29/58 (50%), Positives = 39/58 (67%)

Query: 1862 ILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKE 1919
            + K+   + F EEEEEE+E  +  EED EEK E EE+  + +E+EEKEEEE  EG +E
Sbjct: 619  LFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQE 676



 Score = 48.1 bits (113), Expect = 2e-04
 Identities = 28/54 (51%), Positives = 37/54 (68%), Gaps = 4/54 (7%)

Query: 1875 EEEEDEEEEGEEEDE--EEKEEDEEETA--QEKEDEEKEEEEAAEGEKEEGLEE 1924
            + E+  EEE EEE+E  +E EED EE    +EKE+E +EEEE  E E+EEG +E
Sbjct: 623  DNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQE 676



 Score = 45.1 bits (105), Expect = 0.002
 Identities = 33/102 (32%), Positives = 54/102 (52%), Gaps = 14/102 (13%)

Query: 1854 FGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQ------------ 1901
            F +E+ ++     E E   EE+ E++E+EE  EE+EE++EE+EEE  Q            
Sbjct: 628  FEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEI 687

Query: 1902 EKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLL 1943
            E +DE++ ++E  +G  E G   G L   +P+S+      LL
Sbjct: 688  ETKDEKEMDKENNDGSSEIGKAVGFL--SVPKSLSSDSTLLL 727



 Score = 39.3 bits (90), Expect = 0.10
 Identities = 25/62 (40%), Positives = 33/62 (53%), Gaps = 8/62 (12%)

Query: 1871 FTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKED--------EEKEEEEAAEGEKEEGL 1922
            F E ++ +   +   E+  EE+EE+EEE   E E+        EEKEEE   E EKEE  
Sbjct: 610  FEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEE 669

Query: 1923 EE 1924
            EE
Sbjct: 670  EE 671



 Score = 36.2 bits (82), Expect = 0.85
 Identities = 51/227 (22%), Positives = 90/227 (39%), Gaps = 14/227 (6%)

Query: 1889 EEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLE---EGLLQMKLPESVKLQMCHLLEY 1945
            E E  ++ EET ++ E+ E++ + +A G  E+      + L Q+ +  S+K ++    + 
Sbjct: 457  EGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDS 516

Query: 1946 FCDQELQHRVESLAAFAERY------VDKLQANQRSRYGLLIKAFSMTAAETARRTREFR 1999
            F   E +   E L A  +R+        K +A Q     +++K       E  +      
Sbjct: 517  FVILEPETNRE-LEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPV 575

Query: 2000 SPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGE----EEEPEE 2055
            +   ++++     K G   +      +    L  F +        +LD E    EEE EE
Sbjct: 576  TLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEE 635

Query: 2056 ETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMV 2102
            E           EKV   +K+EE  EEE   EE +    QE    ++
Sbjct: 636  EEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLL 682



 Score = 34.7 bits (78), Expect = 2.5
 Identities = 19/72 (26%), Positives = 36/72 (50%), Gaps = 10/72 (13%)

Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGE----------EEDEEEKEEDEEETAQEKEDE 1906
            + +++ L +      T++EEE++EEE G+          + DE+E  +   + A E  ++
Sbjct: 972  DPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHED 1031

Query: 1907 EKEEEEAAEGEK 1918
            + EEE     EK
Sbjct: 1032 DDEEELLKRSEK 1043


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 58.5 bits (140), Expect = 2e-07
 Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 27/257 (10%)

Query: 1866 IEPEVFTEEEEEE--------DEEEEGEEE----DEEEKEEDEEETAQE--KEDEEKEEE 1911
            ++ E  TE  E+E        D+EEE  E     +EEE+ E +E   Q+  +E EE+ E+
Sbjct: 458  LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517

Query: 1912 EAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQA 1971
                 E+EE L++   +++  + ++ +     E    +E + R+E      ER   +L+ 
Sbjct: 518  RLKRQEEEERLQQ---RLRSEQQLRREQEERREQLLKREEEKRLEQ-----ERREQRLKR 569

Query: 1972 NQRSRYGLLIKAFSMTAAETARRTREFRSP---PQEQINMLLQFKDGTDEEDCPLPEEIR 2028
             Q  R   L+K       +  +R +E R      +E++  L Q +          PEE R
Sbjct: 570  EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629

Query: 2029 QDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEE 2088
            +  L   ++       QL  E++E  E+          LE+ RL ++ EE+  E+  AEE
Sbjct: 630  RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ-RLKREHEEERREQELAEE 688

Query: 2089 SKPRSLQELVSHMVVRW 2105
             + ++ +E +   + +W
Sbjct: 689  EQEQA-RERIKSRIPKW 704



 Score = 55.1 bits (131), Expect = 2e-06
 Identities = 56/246 (22%), Positives = 106/246 (43%), Gaps = 21/246 (8%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLP 1932
            EEE  E +EE  E+++  E++E+  E    +E EE+ E++    ++EE  E+ L + +  
Sbjct: 311  EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370

Query: 1933 ESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETA 1992
            E  + Q+    +   +Q+L+   +       R   +L+  Q+ R             +  
Sbjct: 371  ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-----------REQQL 419

Query: 1993 RRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAH------CGIQL 2046
            RR ++ R   QE+     + +    E+     +E R+D L   ++   H        ++ 
Sbjct: 420  RREQQLRR-EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478

Query: 2047 DGEEEEPEEETTLGS---RLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMVV 2103
            D EEE  E    L     R      + +L +++EE+ E+    +E + R  Q L S   +
Sbjct: 479  DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538

Query: 2104 RWAQED 2109
            R  QE+
Sbjct: 539  RREQEE 544



 Score = 49.3 bits (116), Expect = 1e-04
 Identities = 55/239 (23%), Positives = 106/239 (44%), Gaps = 14/239 (5%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE--KEEEEAAEGEKEEGLEE 1924
            EP     ++ +E E E  E E++ EK+E  E+  +++ DEE  ++ +E  E E+    EE
Sbjct: 132  EPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE 191

Query: 1925 GLLQMK------LPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYG 1978
             L   K       P+  +L+   LLE       + + +        + ++ +   R R  
Sbjct: 192  QLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRET 251

Query: 1979 LLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDL 2038
            +L K       E  +R RE +   +EQ+  L + +   + ++    EE +Q  L   Q L
Sbjct: 252  VLRKEEEKLQEEEPQRQRELQE-EEEQLRKLERQELRRERQE----EEQQQQRLRREQQL 306

Query: 2039 LAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQEL 2097
                  +   ++EE  E+     +     E+ +L +++EE+ E++   E+ + R  Q+L
Sbjct: 307  RRKQEEERREQQEERREQQERREQQEERREQ-QLRREQEERREQQLRREQEEERREQQL 364



 Score = 48.5 bits (114), Expect = 2e-04
 Identities = 61/263 (23%), Positives = 116/263 (44%), Gaps = 37/263 (14%)

Query: 1853 IFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEE 1912
            + G+E  K+  +  E +   EEE +++EE+   EE E+ + ++ E   ++K++ ++EEE+
Sbjct: 973  LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032

Query: 1913 AAEGEKEE-GLEEGLLQMKLPESVKLQMCHLL--------------EYFCDQELQHRVES 1957
                E+E+  L+E   Q +  E ++ +   LL              +Y  ++ELQ   E 
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092

Query: 1958 LAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTD 2017
            L        +K +  +R R     +       +  R  RE R   ++++    + ++   
Sbjct: 1093 L---LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR--RQELERQYREEEEVQ 1147

Query: 2018 EEDCPL----PEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLV 2073
            +E+  L    PE+ R+  L+           Q   EEE  +EE  L   L    EK R  
Sbjct: 1148 QEEEQLLREEPEKRRRQELE----------RQYREEEELQQEEEQL---LREEQEKRRQE 1194

Query: 2074 KKKEEKPEEERSAEESKPRSLQE 2096
            ++++ + EEE   ++ K R   E
Sbjct: 1195 RERQYREEEELQRQKRKQRYRDE 1217



 Score = 47.4 bits (111), Expect = 4e-04
 Identities = 54/240 (22%), Positives = 97/240 (40%), Gaps = 6/240 (2%)

Query: 1871 FTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMK 1930
            + EEE+ + EEE+   E+ E++   E E    K+ + +++EE   GE+ E       + K
Sbjct: 930  YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989

Query: 1931 LPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAE 1990
              E  +LQ         ++E + R E    +  +Y  K +  Q     L  +       E
Sbjct: 990  YREEEELQQEEEQLLREEREKRRRQE----WERQYRKKDELQQEEEQLLREEREKRRLQE 1045

Query: 1991 TARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEE 2050
              R+ RE     QE+  +L + ++    ++        ++L    + LL     +   +E
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105

Query: 2051 EEPE--EETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMVVRWAQE 2108
             E +  EE  L      LL + R  ++++E   + R  EE +    Q L      R  QE
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE 1165



 Score = 47.0 bits (110), Expect = 5e-04
 Identities = 61/288 (21%), Positives = 120/288 (41%), Gaps = 34/288 (11%)

Query: 1856 DEDVKQILKMIEPEVFTEEEE-------EEDEEEEGEEEDEEEKEEDEEETAQEKEDEEK 1908
            +E ++Q LK  E E   +EE        EE EEE  ++  + E++E+  +    +E +E+
Sbjct: 595  EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654

Query: 1909 EEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDK 1968
             E+     E+EE LE+ L +    E  + ++        ++E +   E + +   ++  +
Sbjct: 655  REQRLKREEEEERLEQRLKREHEEERREQEL-------AEEEQEQARERIKSRIPKWQWQ 707

Query: 1969 LQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIR 2028
            L++   +R     K +S    +  +R R+ +   + +    LQ+++          EE R
Sbjct: 708  LESEADARQS---KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764

Query: 2029 QDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEER---S 2085
            +D              Q   EE+       L +R     ++ R ++ +E +  E+R    
Sbjct: 765  RDFT-----------WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813

Query: 2086 AEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGE 2133
             EE + R  Q       +++ +E+  Q     RA    L  + DGL E
Sbjct: 814  EEEKEQRRRQRREREKELQFLEEE-EQLQRRERA--QQLQEEEDGLQE 858



 Score = 47.0 bits (110), Expect = 5e-04
 Identities = 58/265 (21%), Positives = 115/265 (43%), Gaps = 28/265 (10%)

Query: 1860 KQILKMIEPEVFTEEEEEED-EEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEK 1918
            +Q+L+  E E+  EE E+   +E+E +  +EE+ +++EE+  +E+ ++ + +E   +  K
Sbjct: 903  QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962

Query: 1919 EEGLEEGLLQM--KLPESVKLQMCHLLEYFCDQELQHRVESLAA----------FAERYV 1966
            ++ L++   Q+  + PE  + Q     +Y  ++ELQ   E L            +  +Y 
Sbjct: 963  DKKLQQKEEQLLGEEPEKRRRQEREK-KYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021

Query: 1967 DKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEE 2026
             K +  Q     L  +       E  R+ RE     QE+  +L + ++    ++      
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081

Query: 2027 IRQDLLDFHQDLLAHCGIQLDGEEEEPE--EETTLGSRLMSLLEKVRLVKKKEE------ 2078
              ++L    + LL     +   +E E +  EE  L      LL + R  ++++E      
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 2079 ------KPEEERSAEESKPRSLQEL 2097
                  + EE+   EE + R  QEL
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQEL 1166



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 57/257 (22%), Positives = 114/257 (44%), Gaps = 22/257 (8%)

Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPE 1933
            EEE+ + EE+ E +  + K ++E++  +E+ +E++  +E     +E   EE LLQ +  E
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE---EEQLLQER--E 1349

Query: 1934 SVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETAR 1993
               L+       F ++EL+H+ +      E    +L+  +R R   L +   +   E  +
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEE--QRLRRQERER-KFLKEEQQLRCQEREQ 1406

Query: 1994 RTREFRS----PPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGE 2049
            + R+ R       ++Q++   + +   +EE     +E  +  L+  Q L      +   E
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466

Query: 2050 E----EEPEEETTLGSRLMSLLEKVRLVKKKEE----KPEEERSAEESKPRSLQELVSHM 2101
            E    E  E++     R    LE+ + ++++E     + +E RS E  +    +E   H 
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526

Query: 2102 VVRWAQEDFVQSPELVR 2118
              R  Q  F+Q  + +R
Sbjct: 1527 QQR--QRKFLQEEQQLR 1541



 Score = 44.7 bits (104), Expect = 0.002
 Identities = 58/275 (21%), Positives = 108/275 (39%), Gaps = 42/275 (15%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE-KEEEEAA 1914
            +E  +Q+LK  E E   +++   +++E  E+  + E+EE+  E   ++E EE + E+E A
Sbjct: 627  EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686

Query: 1915 EGEKEEGLEE----------------GLLQMKLPESVKLQMCHLLEYFCDQELQHRVESL 1958
            E E+E+  E                    Q K+    + Q         +++ + R   L
Sbjct: 687  EEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746

Query: 1959 AAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDE 2018
                E    + Q  +  R     +  +   +E  R+    R P +EQ    L+ ++    
Sbjct: 747  QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806

Query: 2019 EDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEE 2078
            E   LPEE  ++              Q   +  E E+E       +  LE+   ++++E 
Sbjct: 807  EQRFLPEEEEKE--------------QRRRQRREREKE-------LQFLEEEEQLQRRER 845

Query: 2079 ----KPEEERSAEESKPRSLQELVSHMVVRWAQED 2109
                + EE+   E+ + R  QE       RW  E+
Sbjct: 846  AQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE 880



 Score = 44.3 bits (103), Expect = 0.003
 Identities = 56/258 (21%), Positives = 109/258 (42%), Gaps = 27/258 (10%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEE-----EEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
            +E+  Q  K  E E F +EE+    E      +G EE ++++ E ++   QE+E++E  +
Sbjct: 189  EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248

Query: 1911 EEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQ 1970
             E    ++EE L+E   Q +                  +ELQ   E L     + + + +
Sbjct: 249  RETVLRKEEEKLQEEEPQRQ------------------RELQEEEEQLRKLERQELRRER 290

Query: 1971 ANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQD 2030
              +  +   L +   +   +   R RE +   +EQ     Q ++  +++     EE R+ 
Sbjct: 291  QEEEQQQQRLRREQQLRRKQEEER-REQQEERREQQERREQQEERREQQLRREQEERREQ 349

Query: 2031 LLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESK 2090
             L   Q+       QL  E+EE   E  L  R    L + + ++++++   E++   E +
Sbjct: 350  QLRREQE-EERREQQLRREQEEERREQQL--RREQQLRREQQLRREQQLRREQQLRREQQ 406

Query: 2091 PRSLQELVSHMVVRWAQE 2108
             R  Q+L     +R  Q+
Sbjct: 407  LRREQQLRREQQLRREQQ 424



 Score = 43.5 bits (101), Expect = 0.005
 Identities = 55/231 (23%), Positives = 99/231 (42%), Gaps = 30/231 (12%)

Query: 1863 LKMIEPEVFTEEEEEEDEEE-EGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
            L+  E ++  EE E+   +E E +  +EEE +++EE+  +E+ ++ + +E   +  +EE 
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175

Query: 1922 LEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLI 1981
            L++   Q+   E  K +     +Y  ++ELQ +        +RY D+   +QRS     +
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK-----QRYRDE---DQRSD----L 1223

Query: 1982 KAFSMTAAETARRTREF--RSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLL 2039
            K       E A R  +   +    EQ   L         ED  L +   Q      QDL 
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQL---------EDSQLRDRQSQ------QDLQ 1268

Query: 2040 AHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESK 2090
               G Q + + E+         R     E++   ++KE K  + +S EE +
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319



 Score = 43.1 bits (100), Expect = 0.007
 Identities = 56/244 (22%), Positives = 105/244 (43%), Gaps = 20/244 (8%)

Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
            G E+ +Q  +  +  VF EEEE+E  + E     EEEK ++EE   Q +  EE+E+    
Sbjct: 222  GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281

Query: 1915 EGE--KEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQ-ELQHRVESLAAFAERYVDKLQA 1971
            E +  + E  EE   Q +L    +L+     E    Q E + + E      ER   +L+ 
Sbjct: 282  ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341

Query: 1972 NQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDL 2031
             Q  R    ++       E  RR ++ R   +E+            E+     +++R++ 
Sbjct: 342  EQEERREQQLR----REQEEERREQQLRREQEEE----------RREQQLRREQQLRRE- 386

Query: 2032 LDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKP 2091
                ++       QL  E++   E+     R   L  + +L +++EE+  E++  +E + 
Sbjct: 387  QQLRREQQLRREQQLRREQQLRREQQL--RREQQLRREQQLRREQEEERHEQKHEQERRE 444

Query: 2092 RSLQ 2095
            + L+
Sbjct: 445  QRLK 448



 Score = 42.4 bits (98), Expect = 0.012
 Identities = 69/296 (23%), Positives = 119/296 (40%), Gaps = 54/296 (18%)

Query: 1857 EDVKQILKMIEPEVFTEEE----EEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEE 1912
            ++ +Q L+      F E+E    E E+++   +E D +  EE+ +   QE+E + + + +
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD 1666

Query: 1913 AAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQAN 1972
                E+E+ L+EG       E  +L+       F ++E Q R +      ER    LQ  
Sbjct: 1667 RKFREEEQLLQEG-------EEQQLRRQERDRKFREEEQQLRRQ------ERERKFLQEE 1713

Query: 1973 QRSRYGLLIKAF-------SMTAAETARRTREFRS--------PPQEQINMLLQFKDGTD 2017
            Q+ R   L + F         T  E  RR   +R         P +E+  +  Q +D   
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773

Query: 2018 EEDCPLPEE-IRQDLLDFHQDLLAHCGIQLDGEEEEPE------------EETTLGSRLM 2064
             E+  L +E   Q L     D       QL  E EE +            EE  L  +L 
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL--QLE 1831

Query: 2065 SLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAM 2120
               +++R  + ++ + EE+ + +E   R  QEL       W +E+  +  E  R +
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFATQEKSRREEQEL-------WQEEEQKRRQERERKL 1880



 Score = 40.8 bits (94), Expect = 0.034
 Identities = 57/236 (24%), Positives = 95/236 (40%), Gaps = 38/236 (16%)

Query: 1875 EEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPES 1934
            E++   E++   E EEE+ E + E  + ++  ++E+EE  +  K E   E   Q +  + 
Sbjct: 416  EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475

Query: 1935 VKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARR 1994
            +K           DQE + R        ER++ KL+  +R       +       E  R 
Sbjct: 476  LKR----------DQEEERR--------ERWL-KLEEEERREQQERREQQLRREQEERRE 516

Query: 1995 TREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPE 2054
             R  R   +E++   L+ +     E     EE R+ LL                EEE+  
Sbjct: 517  QRLKRQEEEERLQQRLRSEQQLRREQ----EERREQLLK--------------REEEKRL 558

Query: 2055 EETTLGSRLMSLLEKVR-LVKKKEEKPEEERSAEESKPRSLQELVSHMVVRWAQED 2109
            E+     RL    E+ R  + K+EE+  ++R   E + R  Q L    V R  QE+
Sbjct: 559  EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEE 614



 Score = 40.8 bits (94), Expect = 0.034
 Identities = 28/98 (28%), Positives = 50/98 (51%), Gaps = 13/98 (13%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDE----EETAQEKEDEEKEEEEAAEGEKEEG- 1921
            E +  T+E+   +E+E  +EE+++ ++E E    EE  + ++ EE+   +  E + +EG 
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907

Query: 1922 -----LEEGLLQMKLPESVKLQMCHLLEYFCDQELQHR 1954
                 LE G  Q     SV ++   L EY  +Q  Q+R
Sbjct: 1908 GHGRLLEPGTHQF---ASVPVRSSPLYEYIQEQRSQYR 1942



 Score = 38.5 bits (88), Expect = 0.17
 Identities = 54/257 (21%), Positives = 109/257 (42%), Gaps = 10/257 (3%)

Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
            G+E  ++  ++ + +    +EE   + +E +E +E   EE++ ++ +  E EE  +EE  
Sbjct: 151  GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE-- 208

Query: 1915 EGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQR 1974
            +  + E LE   L+ K  E  + Q     +    +E +           +  +KLQ  + 
Sbjct: 209  QLRRRELLE---LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265

Query: 1975 SRYGLL---IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDL 2031
             R   L    +       +  RR R+     Q+++    Q +   +EE     EE R++ 
Sbjct: 266  QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE-RREQ 324

Query: 2032 LDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKP 2091
             +  +        QL  E+EE  E+     +     E+ +L +++EE+  E++   E + 
Sbjct: 325  QERREQQEERREQQLRREQEERREQQLRREQEEERREQ-QLRREQEEERREQQLRREQQL 383

Query: 2092 RSLQELVSHMVVRWAQE 2108
            R  Q+L     +R  Q+
Sbjct: 384  RREQQLRREQQLRREQQ 400



 Score = 38.1 bits (87), Expect = 0.22
 Identities = 53/256 (20%), Positives = 111/256 (43%), Gaps = 35/256 (13%)

Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE------KEE 1910
            E+ +++ + +  E     E+EE  E+  + E+E+  E++  E   ++E EE      K E
Sbjct: 523  EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582

Query: 1911 EEAAE----GEKEEGLEEGLLQMKLP--ESVKLQMCHLLEYFCDQELQHRVESLAAFAER 1964
            EE  +     E+EE LE+ L + ++   E  + +   L     ++E + ++       ER
Sbjct: 583  EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642

Query: 1965 YVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLP 2024
               +L+  Q+ R                R  R  R   +E++   L+ +   +  +  L 
Sbjct: 643  RQQQLRREQQER----------------REQRLKREEEEERLEQRLKREHEEERREQELA 686

Query: 2025 EEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEER 2084
            EE ++   +  +  +     QL+ E +  +      S++ S   K    ++++E+ EE+R
Sbjct: 687  EEEQEQARERIKSRIPKWQWQLESEADARQ------SKVYSRPRKQEGQRRRQEQ-EEKR 739

Query: 2085 SAEESKPRSLQELVSH 2100
               ES+ +  +E  +H
Sbjct: 740  RRRESELQWQEEERAH 755



 Score = 37.7 bits (86), Expect = 0.29
 Identities = 50/244 (20%), Positives = 105/244 (43%), Gaps = 23/244 (9%)

Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEE--KEEDEEETAQEKEDEE--KEEEE 1912
            E+ +Q+ +      F EEE++  +E   +  +EE+  +E +E++  +++ D +  +EE++
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493

Query: 1913 AAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQAN 1972
                E++    E  L+ + PE   L+         +++  HR +    F +    +L+  
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLE---------EEQQLHRQQRQRKFLQE-EQQLRRQ 1543

Query: 1973 QRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLL 2032
            +R +     +       E  R+ RE     ++Q++   + +    EE     +E  +  +
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQERE-----EQQLSRQERDRKFRLEEQKVRRQEQERKFM 1598

Query: 2033 DFHQDLLAHCGIQLDGEEEE---PEEETTLGSRLMSLLEKVRLVKK-KEEKPEEERSAEE 2088
            +  Q L    G Q   +E +    E+E  L  R    L +    +K  EE+P+  R   E
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658

Query: 2089 SKPR 2092
             + R
Sbjct: 1659 QQLR 1662



 Score = 37.4 bits (85), Expect = 0.38
 Identities = 53/251 (21%), Positives = 97/251 (38%), Gaps = 33/251 (13%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEED-------EEEKEEDEEETAQEKEDEEKEEEEAAEGEKE 1919
            E     EEEE+E    +  E +       EEE+ +  E   Q +E+E+  +E+      +
Sbjct: 807  EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ 866

Query: 1920 EGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGL 1979
            E   +   + +L E  K +  H L  +    LQ ++       +   ++LQ  +R +   
Sbjct: 867  EQRRDQKWRWQLEEERKRRR-HTL--YAKPALQEQLRKEQQLLQEEEEELQREEREK--- 920

Query: 1980 LIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLL 2039
                      E  R+ RE     QE+  +L + ++    ++        + L    + LL
Sbjct: 921  ------RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL 974

Query: 2040 AHCGIQLDGEEEEPE--EETTLGSRLMSLLEKVRLVKKKEE------------KPEEERS 2085
                 +   +E E +  EE  L      LL + R  ++++E            + EE+  
Sbjct: 975  GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLL 1034

Query: 2086 AEESKPRSLQE 2096
             EE + R LQE
Sbjct: 1035 REEREKRRLQE 1045



 Score = 37.4 bits (85), Expect = 0.38
 Identities = 52/272 (19%), Positives = 112/272 (41%), Gaps = 47/272 (17%)

Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEE--EDEEEKEEDEEETAQEKEDE-------- 1906
            E+ +Q+ +      F +EE++   +E G++  +D + K  +EE+  QE+E++        
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578

Query: 1907 ------------EKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHR 1954
                        +++E +  E E++   +EG  Q++     K +    L    +++  HR
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638

Query: 1955 VESLAAFAER--YVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQ-----EQIN 2007
             E    F E    + + +  Q+ R+                R R+FR   Q     E+  
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLRHD---------------RDRKFREEEQLLQEGEEQQ 1683

Query: 2008 MLLQFKDGT-DEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSL 2066
            +  Q +D    EE+  L  + R+      +  L    ++    EEE   + T   +L   
Sbjct: 1684 LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ 1743

Query: 2067 LEKVRLVKKKEEKP--EEERSAEESKPRSLQE 2096
                +++++++ +P  EE++   + + R  +E
Sbjct: 1744 ERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775



 Score = 35.8 bits (81), Expect = 1.1
 Identities = 39/167 (23%), Positives = 79/167 (47%), Gaps = 18/167 (10%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEE------DEEETAQEK------ 1903
            +E  K+  + +E +   EEE +++EE+   EE E+ ++E      +EEE  ++K      
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215

Query: 1904 -EDEEKEEEEAAEGEKEEGLEEGLLQMKLPESV---KLQMCHLLEYFCDQELQHRVESLA 1959
             ED+  + +   E EKE  + +  +  K  E+    +L+   L +    Q+LQH +    
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275

Query: 1960 AFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQI 2006
               +R  ++ +  QR R+    +       + A+R R+ +S  ++Q+
Sbjct: 1276 E-RDREQERRRWQQRDRHFPEEEQLEREEQKEAKR-RDRKSQEEKQL 1320



 Score = 35.4 bits (80), Expect = 1.4
 Identities = 53/295 (17%), Positives = 126/295 (42%), Gaps = 37/295 (12%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEG----EEEDEEEKEEDEEETAQEKEDEEKEEE 1911
            + + +Q+ +      F  EE++   +E+     E+E +  ++E +++  QE++ + +E+E
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE 1625

Query: 1912 EAAEGEKEEGLEEGLLQMKL----PESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVD 1967
            +  +  +E+ L       K     P+  + +    L +  D++ +   + L    E+ + 
Sbjct: 1626 QLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685

Query: 1968 KLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEI 2027
            + + +++ R             +  RR    R   QE+  +  Q  +    E+  L +E 
Sbjct: 1686 RQERDRKFR----------EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET 1735

Query: 2028 RQDLL---DFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKP---- 2080
             Q+ L   + ++ +L    ++ + EE++   +     R     E+ +L +++EE+     
Sbjct: 1736 EQEQLRRQERYRKILEEEQLRPEREEQQLRRQ----ERDRKFREEEQLRQEREEQQLRSQ 1791

Query: 2081 -------EEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQY 2128
                   EEE+  +E + + L+        RW +E+ +Q  E  + +     RQY
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRW-EEEQLQLEEQEQRLRQERDRQY 1845



 Score = 34.7 bits (78), Expect = 2.5
 Identities = 52/244 (21%), Positives = 100/244 (40%), Gaps = 17/244 (6%)

Query: 1871 FTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMK 1930
            F EEEE+    E  ++  EEE    E++  +  +++ ++++   + E+E       L  K
Sbjct: 833  FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892

Query: 1931 --LPESVKLQMCHLLEYFCDQELQHRVESLAAFAER-YVDKLQANQRSRYGLLIKAFSMT 1987
              L E ++ +   L E   + + + R +      ER Y ++ Q  Q     L  +     
Sbjct: 893  PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952

Query: 1988 AAETARRTREFRSPPQEQINML----------LQFKDGTDEEDCPLPEE--IRQDLLDFH 2035
              E  R+ R+ +   Q++  +L           + K   +EE+    EE  +R++     
Sbjct: 953  RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012

Query: 2036 QDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERS--AEESKPRS 2093
            +        + D  ++E E+          L E+ R  +++EE  +EE     EE + R 
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR 1072

Query: 2094 LQEL 2097
             QEL
Sbjct: 1073 RQEL 1076



 Score = 34.3 bits (77), Expect = 3.2
 Identities = 60/278 (21%), Positives = 113/278 (40%), Gaps = 23/278 (8%)

Query: 1857 EDVKQILKMIEPEVFTEEEEE----EDEEEEGEEEDEEEKEEDEEETAQEKEDE--EKEE 1910
            E+ +++ +      F +EE++    E E++  ++ D + +EE+++ + QE++ +  E+E+
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437

Query: 1911 EEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQ 1970
            +   +  + + LEE        E    Q  H      +Q LQ R E      ER    L+
Sbjct: 1438 QVRRQERERKFLEE--------EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLE 1489

Query: 1971 ANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQD 2030
              Q+ R     + F      +    R+F    Q+      Q K   +E+     E  +Q 
Sbjct: 1490 EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549

Query: 2031 LLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESK 2090
              D  +D       QL  E EE +       R      K RL ++K  + E+ER   E +
Sbjct: 1550 RQD--RDRKFREEEQLRQEREEQQLSRQERDR------KFRLEEQKVRRQEQERKFMEDE 1601

Query: 2091 PRSLQELVSHMVVRWAQEDFVQSPELVRAM-FSLLHRQ 2127
             +  ++     + +     F +  +L++      LHRQ
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ 1639



 Score = 32.7 bits (73), Expect = 9.4
 Identities = 16/58 (27%), Positives = 33/58 (56%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            E ++  EE+E+   +E   +   EE+   +E++ +E+++  +EEE+    E+E  L E
Sbjct: 1825 EEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882


>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
            [Homo sapiens]
          Length = 2073

 Score = 58.2 bits (139), Expect = 2e-07
 Identities = 30/65 (46%), Positives = 44/65 (67%), Gaps = 5/65 (7%)

Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPE 1933
            E  +E  EEE EEEDEEE+EE+EEE   E+E+EE+EEE     E+EE ++    ++  P+
Sbjct: 1063 ELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEE-----EEEENIQSSPPRLTKPQ 1117

Query: 1934 SVKLQ 1938
            SV ++
Sbjct: 1118 SVAIK 1122



 Score = 55.1 bits (131), Expect = 2e-06
 Identities = 24/42 (57%), Positives = 35/42 (83%)

Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
            E+  E  EEE+EEE+ EEE+EEE+EE++EE  +E+E+EE+EE
Sbjct: 1063 ELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEE 1104



 Score = 55.1 bits (131), Expect = 2e-06
 Identities = 26/41 (63%), Positives = 32/41 (78%)

Query: 1866 IEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDE 1906
            +  E   EEEEEEDEEEE EEE+EEE EE+EEE  +E+E+E
Sbjct: 1064 LSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEE 1104



 Score = 52.4 bits (124), Expect = 1e-05
 Identities = 36/105 (34%), Positives = 53/105 (50%), Gaps = 20/105 (19%)

Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEED-------------EEEKEEDEEETAQ 1901
            G++    ++K  E E   EEEEEE+EEEEGEEE+              +EKEE E  T +
Sbjct: 1340 GEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEK 1399

Query: 1902 E-------KEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQM 1939
            E        E+EE+E+EE +  E  +  +E    M+  E  K ++
Sbjct: 1400 EDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEEL 1444



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 23/45 (51%), Positives = 36/45 (80%)

Query: 1861 QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKED 1905
            Q+L++ +     EEEEE++EEEE EEE+EE++EE+EEE  +E+E+
Sbjct: 1060 QLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEE 1104



 Score = 43.9 bits (102), Expect = 0.004
 Identities = 24/60 (40%), Positives = 36/60 (60%), Gaps = 5/60 (8%)

Query: 1866 IEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDE-----EKEEEEAAEGEKEE 1920
            + P     E+ E+D  +  EEE+EEE+EE+EEE  + +E+E     EK+ + A   EKEE
Sbjct: 1333 VSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEE 1392



 Score = 40.0 bits (92), Expect = 0.059
 Identities = 23/69 (33%), Positives = 39/69 (56%), Gaps = 4/69 (5%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            +E+VK+  + + P+    EE   +E       +    E+ E++  + +E+EE+EEEE  E
Sbjct: 1308 EEEVKETGEALLPQ----EENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEE 1363

Query: 1916 GEKEEGLEE 1924
             E+EEG EE
Sbjct: 1364 EEEEEGEEE 1372



 Score = 35.0 bits (79), Expect = 1.9
 Identities = 29/91 (31%), Positives = 40/91 (43%), Gaps = 36/91 (39%)

Query: 1867 EPEVFTEEEEEEDE----------EEEGEEEDEE-----------------------EKE 1893
            + +V  EE++E  E          EEE +E  E                        EK 
Sbjct: 1284 DEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKP 1343

Query: 1894 EDE---EETAQEKEDEEKEEEEAAEGEKEEG 1921
            ED+    E  +E+E+EE+EEEE  EGE+EEG
Sbjct: 1344 EDDLIKPEEEEEEEEEEEEEEEEEEGEEEEG 1374



 Score = 33.9 bits (76), Expect = 4.2
 Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 1/74 (1%)

Query: 4463 AEPPTPEGSPILK-RKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEP 4521
            + P T E   +L+  K   +  EEE   E E E E E E E+ + E  E+EE       P
Sbjct: 1051 SRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSP 1110

Query: 4522 PKKQAPPSPPPKKE 4535
            P+   P S   K++
Sbjct: 1111 PRLTKPQSVAIKRK 1124


>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
          Length = 709

 Score = 58.2 bits (139), Expect = 2e-07
 Identities = 29/57 (50%), Positives = 42/57 (73%), Gaps = 1/57 (1%)

Query: 1866 IEPEVFTEEEEEEDEEEEGE-EEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
            +E +V  +EE EED EE+ E +ED EE+EE+EEE  +E+E+EE+E E+    +KEEG
Sbjct: 205  VEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEG 261



 Score = 56.6 bits (135), Expect = 6e-07
 Identities = 28/54 (51%), Positives = 38/54 (70%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
            E E   E+ EE++E EE  EEDEE  E+ EEE  +E+E+EE+EEEE  E E++E
Sbjct: 201  EEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDE 254



 Score = 53.5 bits (127), Expect = 5e-06
 Identities = 27/70 (38%), Positives = 46/70 (65%), Gaps = 1/70 (1%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            +EDV++  + +E +   +EE +ED EEE EEE+EEE+EE+EEE   E+++ +++EE    
Sbjct: 206  EEDVEED-EEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDY 264

Query: 1916 GEKEEGLEEG 1925
              + E  + G
Sbjct: 265  DTRSEASDSG 274



 Score = 52.4 bits (124), Expect = 1e-05
 Identities = 29/72 (40%), Positives = 42/72 (58%), Gaps = 2/72 (2%)

Query: 1856 DEDVKQILKMIEP--EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEA 1913
            DE+V++  +  E   E   EEEEEE+EEEE EEE+EEE E+DE +  +E  D +   E +
Sbjct: 212  DEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEAS 271

Query: 1914 AEGEKEEGLEEG 1925
              G +     +G
Sbjct: 272  DSGSESVSFTDG 283



 Score = 51.6 bits (122), Expect = 2e-05
 Identities = 25/49 (51%), Positives = 35/49 (71%)

Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
            TE EEE  EE+  E+E+ EE  E++EE  ++ E+EE+EEEE  E E+EE
Sbjct: 198  TENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEE 246



 Score = 50.8 bits (120), Expect = 3e-05
 Identities = 25/51 (49%), Positives = 35/51 (68%)

Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            E EEE  EE+ EE++E E++ +E+E   E  +EE+EEEE  E E+EE  EE
Sbjct: 199  ENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEE 249



 Score = 49.7 bits (117), Expect = 7e-05
 Identities = 27/53 (50%), Positives = 35/53 (66%), Gaps = 1/53 (1%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKE-DEEKEEEEAAEGEKEEGLEE 1924
            E+    + EEEG EED EE EE EE+  +++E DE+ EEEE  E E+EE  EE
Sbjct: 193  EQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEE 245



 Score = 47.4 bits (111), Expect = 4e-04
 Identities = 23/67 (34%), Positives = 40/67 (59%)

Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG 1916
            E+ +++ +  E +   +E+ EE+EEEE EEE+EEE+EE+E E  +  + EE  + +    
Sbjct: 210  EEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSE 269

Query: 1917 EKEEGLE 1923
              + G E
Sbjct: 270  ASDSGSE 276



 Score = 42.7 bits (99), Expect = 0.009
 Identities = 22/53 (41%), Positives = 30/53 (56%)

Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            T      DE+    E +EE  EED EE  + +ED E++EE   +GE+EE  EE
Sbjct: 185  TGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEE 237



 Score = 42.0 bits (97), Expect = 0.015
 Identities = 19/49 (38%), Positives = 31/49 (63%)

Query: 1876 EEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            +E+    E EEE  EE  E++EE  ++ E++E+ +E+  E E+EE  EE
Sbjct: 192  DEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEE 240



 Score = 39.3 bits (90), Expect = 0.10
 Identities = 19/55 (34%), Positives = 30/55 (54%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
            E E   EEEEEE+EEE  ++E ++++E ++ +T  E  D   E     +G    G
Sbjct: 234  EEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSG 288



 Score = 33.9 bits (76), Expect = 4.2
 Identities = 22/75 (29%), Positives = 34/75 (45%)

Query: 1851 MGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
            +G+  D    +  +  + EV +EE   + E       DE+    + EE   E++ EE EE
Sbjct: 155  IGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEE 214

Query: 1911 EEAAEGEKEEGLEEG 1925
             E    E EE  E+G
Sbjct: 215  VEEDAEEDEEVDEDG 229


>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
          Length = 727

 Score = 58.2 bits (139), Expect = 2e-07
 Identities = 29/57 (50%), Positives = 42/57 (73%), Gaps = 1/57 (1%)

Query: 1866 IEPEVFTEEEEEEDEEEEGE-EEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
            +E +V  +EE EED EE+ E +ED EE+EE+EEE  +E+E+EE+E E+    +KEEG
Sbjct: 205  VEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEG 261



 Score = 56.6 bits (135), Expect = 6e-07
 Identities = 28/54 (51%), Positives = 38/54 (70%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
            E E   E+ EE++E EE  EEDEE  E+ EEE  +E+E+EE+EEEE  E E++E
Sbjct: 201  EEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDE 254



 Score = 53.5 bits (127), Expect = 5e-06
 Identities = 27/70 (38%), Positives = 46/70 (65%), Gaps = 1/70 (1%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            +EDV++  + +E +   +EE +ED EEE EEE+EEE+EE+EEE   E+++ +++EE    
Sbjct: 206  EEDVEED-EEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDY 264

Query: 1916 GEKEEGLEEG 1925
              + E  + G
Sbjct: 265  DTRSEASDSG 274



 Score = 52.4 bits (124), Expect = 1e-05
 Identities = 29/72 (40%), Positives = 42/72 (58%), Gaps = 2/72 (2%)

Query: 1856 DEDVKQILKMIEP--EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEA 1913
            DE+V++  +  E   E   EEEEEE+EEEE EEE+EEE E+DE +  +E  D +   E +
Sbjct: 212  DEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEAS 271

Query: 1914 AEGEKEEGLEEG 1925
              G +     +G
Sbjct: 272  DSGSESVSFTDG 283



 Score = 51.6 bits (122), Expect = 2e-05
 Identities = 25/49 (51%), Positives = 35/49 (71%)

Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
            TE EEE  EE+  E+E+ EE  E++EE  ++ E+EE+EEEE  E E+EE
Sbjct: 198  TENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEE 246



 Score = 50.8 bits (120), Expect = 3e-05
 Identities = 25/51 (49%), Positives = 35/51 (68%)

Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            E EEE  EE+ EE++E E++ +E+E   E  +EE+EEEE  E E+EE  EE
Sbjct: 199  ENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEE 249



 Score = 49.7 bits (117), Expect = 7e-05
 Identities = 27/53 (50%), Positives = 35/53 (66%), Gaps = 1/53 (1%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKE-DEEKEEEEAAEGEKEEGLEE 1924
            E+    + EEEG EED EE EE EE+  +++E DE+ EEEE  E E+EE  EE
Sbjct: 193  EQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEE 245



 Score = 47.4 bits (111), Expect = 4e-04
 Identities = 23/67 (34%), Positives = 40/67 (59%)

Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG 1916
            E+ +++ +  E +   +E+ EE+EEEE EEE+EEE+EE+E E  +  + EE  + +    
Sbjct: 210  EEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSE 269

Query: 1917 EKEEGLE 1923
              + G E
Sbjct: 270  ASDSGSE 276



 Score = 42.7 bits (99), Expect = 0.009
 Identities = 22/53 (41%), Positives = 30/53 (56%)

Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            T      DE+    E +EE  EED EE  + +ED E++EE   +GE+EE  EE
Sbjct: 185  TGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEE 237



 Score = 42.0 bits (97), Expect = 0.015
 Identities = 19/49 (38%), Positives = 31/49 (63%)

Query: 1876 EEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            +E+    E EEE  EE  E++EE  ++ E++E+ +E+  E E+EE  EE
Sbjct: 192  DEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEE 240



 Score = 39.3 bits (90), Expect = 0.10
 Identities = 19/55 (34%), Positives = 30/55 (54%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
            E E   EEEEEE+EEE  ++E ++++E ++ +T  E  D   E     +G    G
Sbjct: 234  EEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSG 288



 Score = 33.9 bits (76), Expect = 4.2
 Identities = 22/75 (29%), Positives = 34/75 (45%)

Query: 1851 MGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
            +G+  D    +  +  + EV +EE   + E       DE+    + EE   E++ EE EE
Sbjct: 155  IGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEE 214

Query: 1911 EEAAEGEKEEGLEEG 1925
             E    E EE  E+G
Sbjct: 215  VEEDAEEDEEVDEDG 229


>gi|60498973 myelin transcription factor 1-like [Homo sapiens]
          Length = 1184

 Score = 57.8 bits (138), Expect = 3e-07
 Identities = 28/52 (53%), Positives = 41/52 (78%), Gaps = 1/52 (1%)

Query: 1874 EEEEEDEEEEGEEEDE-EEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            +E+EEDEE + EEE+E EE++ED++E  ++ EDEE+EEEE  E E+EE  E+
Sbjct: 119  DEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENED 170



 Score = 55.5 bits (132), Expect = 1e-06
 Identities = 26/52 (50%), Positives = 38/52 (73%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            E  +E++E+EEG+ E+EEE EE++E+  ++ ED E EEEE  E E+EE  EE
Sbjct: 116  EPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEE 167



 Score = 54.3 bits (129), Expect = 3e-06
 Identities = 28/55 (50%), Positives = 38/55 (69%), Gaps = 1/55 (1%)

Query: 1867 EPEVFTEEEEEEDEEEEGE-EEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
            EP    EE+EE D EEE E EE++E+ +ED E+   E+E+EE+EEEE  E E E+
Sbjct: 116  EPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENED 170



 Score = 50.8 bits (120), Expect = 3e-05
 Identities = 25/55 (45%), Positives = 38/55 (69%)

Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKE 1909
            GDED +      E E   EEE+E+D+E+  + EDEEE+EE+EEE  +E+E+E+ +
Sbjct: 118  GDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENEDHQ 172



 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 27/62 (43%), Positives = 38/62 (61%), Gaps = 2/62 (3%)

Query: 1865 MIEPEVFTEEEEEEDEEEEGEE--EDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGL 1922
            M E E    EE  ED +E G+E  EDEE   E+EEE  +E ED++++ E+  + E+EE  
Sbjct: 99   MDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEE 158

Query: 1923 EE 1924
            EE
Sbjct: 159  EE 160



 Score = 43.1 bits (100), Expect = 0.007
 Identities = 22/55 (40%), Positives = 36/55 (65%), Gaps = 2/55 (3%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE--KEEEEAAEGEKEEGLEEG 1925
            + +  ED +E+ E+E EE  E+++E   +++EDEE  +EEEE  E E E+  E+G
Sbjct: 92   DSDGTEDMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDG 146



 Score = 40.0 bits (92), Expect = 0.059
 Identities = 23/51 (45%), Positives = 32/51 (62%), Gaps = 4/51 (7%)

Query: 1877 EEDEEEEGEEEDEEEKEEDEEETAQEKEDE---EKEEEEAAEGEKEEGLEE 1924
            +E ++ +G E D +EKEEDE E   E  DE   E EE+E  + E+EE +EE
Sbjct: 88   DECDDSDGTE-DMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEE 137



 Score = 38.9 bits (89), Expect = 0.13
 Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 3/51 (5%)

Query: 1875 EEEEDEEEEGEEEDEEEKEEDEE---ETAQEKEDEEKEEEEAAEGEKEEGL 1922
            E+EE+EEEE EEE+EEE+ ED +      +  +D EK++    E +  + L
Sbjct: 150  EDEEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDEL 200



 Score = 38.1 bits (87), Expect = 0.22
 Identities = 25/71 (35%), Positives = 40/71 (56%), Gaps = 2/71 (2%)

Query: 3663 LTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTAL-TEKSKLDEDYL 3721
            + E+   +D   +D+    E+EEEEEE EE++ +  HQ+  H +R    TEK   + D  
Sbjct: 135  IEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDE- 193

Query: 3722 YMAYADIMAKS 3732
            Y  Y +++AKS
Sbjct: 194  YDNYDELVAKS 204



 Score = 37.7 bits (86), Expect = 0.29
 Identities = 20/61 (32%), Positives = 34/61 (55%)

Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQ 1928
            +V  EEEEEE+EEEE EEE+ E+ + +   T   ++ E+ +         +E + + LL 
Sbjct: 148  DVEDEEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLN 207

Query: 1929 M 1929
            +
Sbjct: 208  L 208



 Score = 37.4 bits (85), Expect = 0.38
 Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 2/51 (3%)

Query: 1876 EEEDEEEEGEEEDEEEKEEDEE--ETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            +E D+ +  E+ DE+E++E EE  E   E  DE++E+EE    E+EE  EE
Sbjct: 88   DECDDSDGTEDMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEE 138


>gi|21735415 centromere protein B [Homo sapiens]
          Length = 599

 Score = 57.4 bits (137), Expect = 4e-07
 Identities = 29/52 (55%), Positives = 37/52 (71%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            EEEEEE+EEEEGE E+EEE+ E+EEE   E E+  +EEE   EG+ +   EE
Sbjct: 409  EEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEE 460



 Score = 55.5 bits (132), Expect = 1e-06
 Identities = 36/72 (50%), Positives = 43/72 (59%), Gaps = 11/72 (15%)

Query: 1863 LKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDE-----EETAQEKEDEEK------EEE 1911
            LK    E   EEEEEE+EE EGEEE+EE +EE+E     EE  +E+E EE+      EEE
Sbjct: 401  LKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEE 460

Query: 1912 EAAEGEKEEGLE 1923
            E  E    EGLE
Sbjct: 461  EEDEESSSEGLE 472



 Score = 53.5 bits (127), Expect = 5e-06
 Identities = 29/52 (55%), Positives = 34/52 (65%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            EEEEEE+EEEE E E EEE+EE EEE  +  E EE  EEE  E E +   +E
Sbjct: 407  EEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDE 458



 Score = 52.8 bits (125), Expect = 9e-06
 Identities = 27/44 (61%), Positives = 33/44 (75%)

Query: 1881 EEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            + EGEEE+EEE+EE+EEE   E+E+EE EEEE   GE EE  EE
Sbjct: 402  KSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEE 445



 Score = 52.4 bits (124), Expect = 1e-05
 Identities = 29/71 (40%), Positives = 43/71 (60%), Gaps = 9/71 (12%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDE---------EEKEEDEEETAQEKEDEEKEEEEAAEGE 1917
            E E   EE E E+EEEEGEEE+E         EE+E +EE      E+EE++EE ++EG 
Sbjct: 412  EEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGL 471

Query: 1918 KEEGLEEGLLQ 1928
            + E   +G+++
Sbjct: 472  EAEDWAQGVVE 482



 Score = 50.8 bits (120), Expect = 3e-05
 Identities = 27/56 (48%), Positives = 37/56 (66%)

Query: 1870 VFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            + T  + E +EEEE EEE+EEE+ E EEE  + +E+EE+  E    GE+EE  EEG
Sbjct: 397  ITTSLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEG 452



 Score = 38.5 bits (88), Expect = 0.17
 Identities = 56/209 (26%), Positives = 77/209 (36%), Gaps = 35/209 (16%)

Query: 4322 RLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELLA 4381
            +L   EA   VAA  W AV  +  A     AG         FGGG          T L +
Sbjct: 358  QLGLTEALHFVAAA-WQAVEPSDIAACFREAG---------FGGG----PNATITTSLKS 403

Query: 4382 GMPDPTSDEVHGEQPAGPGGDADGEGASEGA-GDAAEGAGDEEEAVHEAGPGGADG---- 4436
               +   +E   E+  G G + + EG  E   G   E  G+EEE V E G   +D     
Sbjct: 404  EGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEE-VEEEGDVDSDEEEEE 462

Query: 4437 -------AVAVTDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPP 4489
                    +   D      E  G  G  G    A+ PT      L    G +  + +   
Sbjct: 463  DEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPT------LHFLEGGEDSDSDSEE 516

Query: 4490 EPEPEPEPELEPEKADAENGEKEEVPEPT 4518
            E + E + E E +  D E+G+  EVP P+
Sbjct: 517  EDDEEEDDEDEDDDDDEEDGD--EVPVPS 543



 Score = 38.5 bits (88), Expect = 0.17
 Identities = 19/41 (46%), Positives = 28/41 (68%)

Query: 1886 EEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGL 1926
            + + EE+EE+EEE  +E+ + E+EEEE  E E+E G  E L
Sbjct: 402  KSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEEL 442



 Score = 37.7 bits (86), Expect = 0.29
 Identities = 14/27 (51%), Positives = 23/27 (85%)

Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEE 1898
            ++ EEE+DEEE+ E+ED+++ EED +E
Sbjct: 512  SDSEEEDDEEEDDEDEDDDDDEEDGDE 538



 Score = 37.4 bits (85), Expect = 0.38
 Identities = 15/34 (44%), Positives = 23/34 (67%)

Query: 1882 EEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            E GE+ D + +EED+EE   E ED++ +EE+  E
Sbjct: 505  EGGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDE 538



 Score = 35.0 bits (79), Expect = 1.9
 Identities = 15/51 (29%), Positives = 30/51 (58%)

Query: 1852 GIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQE 1902
            G +G ++  Q   +   E   + + + +EE++ EE+DE+E ++D+EE   E
Sbjct: 488  GAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDE 538



 Score = 35.0 bits (79), Expect = 1.9
 Identities = 16/37 (43%), Positives = 25/37 (67%), Gaps = 1/37 (2%)

Query: 1871 FTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE 1907
            F E  E+ D + E EE+DEEE +EDE++   E++ +E
Sbjct: 503  FLEGGEDSDSDSE-EEDDEEEDDEDEDDDDDEEDGDE 538



 Score = 34.7 bits (78), Expect = 2.5
 Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 30/88 (34%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEE------------------------------EKEEDE 1896
            E +V ++EEEEEDEE   E  + E                              E  ED 
Sbjct: 451  EGDVDSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDS 510

Query: 1897 EETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            +  ++E++DEE+++E+  + + EE  +E
Sbjct: 511  DSDSEEEDDEEEDDEDEDDDDDEEDGDE 538


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
            [Homo sapiens]
          Length = 899

 Score = 57.4 bits (137), Expect = 4e-07
 Identities = 62/261 (23%), Positives = 117/261 (44%), Gaps = 20/261 (7%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            +E +++  +M E E    EEEE   E+E + +++EEK +++EE   E+E++ +E+EE   
Sbjct: 582  EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMW 641

Query: 1916 GEKE---EGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQAN 1972
             ++E   E  E+   Q +LPE  +    H  E   +QE     E      E+   K Q  
Sbjct: 642  EQEEKMWEQEEKMWEQQRLPEQKEKLWEH--EKMQEQEKMQEQEEKIWEQEKMEKKTQEQ 699

Query: 1973 QRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEE----IR 2028
            ++  +         +  E  ++ RE     +EQ   + + ++   E++  + E+      
Sbjct: 700  EKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWE 759

Query: 2029 QDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEE 2088
            Q+   + Q  L     +L   E+  E+E     ++    EK+R  ++K    EE+   +E
Sbjct: 760  QEEKMWEQQRLPEQKEKLWEHEKMQEQE-----KIWEQEEKMRDQEEKMRGQEEKMRGQE 814

Query: 2089 SKPRSLQELVSHMVVRWAQED 2109
             K R  +E +      W QE+
Sbjct: 815  EKMRGQEEKM------WGQEE 829



 Score = 53.5 bits (127), Expect = 5e-06
 Identities = 61/259 (23%), Positives = 116/259 (44%), Gaps = 45/259 (17%)

Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG 1916
            E +++  KM E E  T ++EE+ +EEE   E E++  E+EE   +++E  +K+EE   E 
Sbjct: 424  EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483

Query: 1917 EKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSR 1976
            E++E       Q +LPE  +       + +  +++Q + E +    E+  D     Q   
Sbjct: 484  EEKE-----WQQQRLPEQKE-------KLWEQEKMQEQEEKIWEQEEKIRD-----QEEM 526

Query: 1977 YGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQ 2036
            +G           +  +  R+ +   QE   M  Q +   D+E     +E R +     Q
Sbjct: 527  WG-----------QEKKMWRQEKMREQED-QMWEQEEKMRDQEQKMWDQEERMEKKTQEQ 574

Query: 2037 DLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQE 2096
            +       +   +EE+  EE  +  R   + E+  +++++EEK +E    +E K +  +E
Sbjct: 575  EK------KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE----QEEKMQEQEE 624

Query: 2097 LVSHMVVRWAQEDFVQSPE 2115
             +      W QE+ +Q  E
Sbjct: 625  KM------WEQEEKMQEQE 637



 Score = 49.3 bits (116), Expect = 1e-04
 Identities = 59/264 (22%), Positives = 113/264 (42%), Gaps = 19/264 (7%)

Query: 1864 KMIEPEVFTE-------EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG 1916
            K + P+V T         +EEE  E+E +   +EEK   +EE  +E+E + +E+EE    
Sbjct: 259  KFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-W 317

Query: 1917 EKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSR 1976
             +E+ L E   +++  E    +   L E   ++++Q + E +    E+  ++ +   R  
Sbjct: 318  RQEKRLREQEKELREQEKELREQKELREQ--EEQMQEQEEKMWEQEEKMREQEEKMWRQE 375

Query: 1977 YGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQ 2036
              L  +   M   E   R +E R   Q++     + +    E+     E++R++     Q
Sbjct: 376  ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435

Query: 2037 DLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEE---KPEEERSAEESKPRS 2093
            +       +   +EE+ +EE  +  R   + E+   ++++EE   K EE    +E K   
Sbjct: 436  EK------KTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489

Query: 2094 LQELVSHMVVRWAQEDFVQSPELV 2117
             Q L       W QE   +  E +
Sbjct: 490  QQRLPEQKEKLWEQEKMQEQEEKI 513



 Score = 48.1 bits (113), Expect = 2e-04
 Identities = 67/278 (24%), Positives = 116/278 (41%), Gaps = 51/278 (18%)

Query: 1864 KMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLE 1923
            KM E E    E+EE+ +E+E + +++EEK  ++EE  QE+E++  E+EE    E+EE + 
Sbjct: 597  KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKM-WEQEEKMW 655

Query: 1924 EGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKA 1983
            E   Q +LPE  +    H  E   +QE     E      E+   K Q  ++  +      
Sbjct: 656  E---QQRLPEQKEKLWEH--EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710

Query: 1984 FSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEI------------RQDL 2031
               +  E  ++ RE     +EQ   + + ++   E++  + E+             +Q L
Sbjct: 711  EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770

Query: 2032 LDFHQDLLAHCGIQLDG---EEEEP---EEETTLGS--RLMSLLEKVRLVKKK------- 2076
             +  + L  H  +Q      E+EE    +EE   G   ++    EK+R  ++K       
Sbjct: 771  PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830

Query: 2077 ------------------EEKPEEERSAEESKPRSLQE 2096
                              EEK EE+   +E K R  +E
Sbjct: 831  MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE 868



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 60/255 (23%), Positives = 111/255 (43%), Gaps = 42/255 (16%)

Query: 1864 KMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGE-----K 1918
            KM   E    E+E+E  E+E E  +++E  E EE+  +++E   ++EE+  E E     +
Sbjct: 315  KMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ 374

Query: 1919 EEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERY--VDKLQANQRSR 1976
            EE L E   QM+  E  K++      +  D+ L+ + E +    + +  V+K++  ++ +
Sbjct: 375  EERLWEQEKQMREQEQ-KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQ 433

Query: 1977 YGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQ 2036
                         E  ++TR+     QE+  +  + K   +EE+    +E +        
Sbjct: 434  -------------EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK-------- 472

Query: 2037 DLLAHCGIQLDGEEE---EPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRS 2093
                     +  +EE   E EE+     RL    EK+   +K +E+ EE+   +E K R 
Sbjct: 473  ---------MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ-EEKIWEQEEKIRD 522

Query: 2094 LQELVSHMVVRWAQE 2108
             +E+       W QE
Sbjct: 523  QEEMWGQEKKMWRQE 537



 Score = 45.1 bits (105), Expect = 0.002
 Identities = 51/267 (19%), Positives = 123/267 (46%), Gaps = 12/267 (4%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            ++++++  ++ E E   +E+EE+  E+E +  ++EEK   +EE   E+E + +E+E+   
Sbjct: 334  EKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMR 393

Query: 1916 GEKEEGLEEGLLQMKLPESVKLQ--MCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQ 1973
             ++E   E+     +  E ++ Q  M   +E   +++     E      E   +K+Q  +
Sbjct: 394  DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE---EKMQEEE 450

Query: 1974 RSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEE--IRQDL 2031
            R R     +   M   E   R +E +   QE+ NM  Q +    ++  P  +E    Q+ 
Sbjct: 451  RIRE----REKKMREEEETMREQEEKMQKQEE-NMWEQEEKEWQQQRLPEQKEKLWEQEK 505

Query: 2032 LDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKP 2091
            +   ++ +     ++  +EE   +E  +  +     ++ ++ +++E+  ++E+   + + 
Sbjct: 506  MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 565

Query: 2092 RSLQELVSHMVVRWAQEDFVQSPELVR 2118
            R  ++        W QE+ ++  E +R
Sbjct: 566  RMEKKTQEQEKKTWDQEEKMREEERMR 592



 Score = 37.4 bits (85), Expect = 0.38
 Identities = 18/56 (32%), Positives = 38/56 (67%), Gaps = 2/56 (3%)

Query: 1867 EPEVFTEEEEEEDEEEEGEE--EDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
            E +++ +EE+   +EE+ EE  + +EEK  ++EE  + +E++ +E+EE   G++E+
Sbjct: 835  EEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890



 Score = 36.6 bits (83), Expect = 0.65
 Identities = 22/62 (35%), Positives = 39/62 (62%), Gaps = 4/62 (6%)

Query: 1867 EPEVFTEEEEEEDEEEE--GEEEDEEEKEEDEEETAQEKEDEEKEEEEAA--EGEKEEGL 1922
            E +++ +EE+   +EE+  G+EE  EEK + +EE  +E+E++ + +EE    + EK  G 
Sbjct: 828  EEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887

Query: 1923 EE 1924
            EE
Sbjct: 888  EE 889



 Score = 36.2 bits (82), Expect = 0.85
 Identities = 20/60 (33%), Positives = 38/60 (63%), Gaps = 2/60 (3%)

Query: 1867 EPEVFTEEEEEEDEEEE--GEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            E +++ +EE+   +EE+  G+EE    +EE  EE  Q +E++ +E+EE   G++E+  E+
Sbjct: 821  EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 57.4 bits (137), Expect = 4e-07
 Identities = 31/57 (54%), Positives = 38/57 (66%)

Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            EV   + E E+EEEEGE E+EE + E+EE   +E+E E K EEE  EGE EE  EEG
Sbjct: 818  EVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEG 874



 Score = 57.4 bits (137), Expect = 4e-07
 Identities = 35/66 (53%), Positives = 40/66 (60%), Gaps = 7/66 (10%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKE-------EEEAAEGEKE 1919
            E E   EE E E EEEEGEEE EEE E +EE   + +E+EE E       EE   EGE+E
Sbjct: 978  EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEE 1037

Query: 1920 EGLEEG 1925
            EG EEG
Sbjct: 1038 EGEEEG 1043



 Score = 53.9 bits (128), Expect = 4e-06
 Identities = 30/53 (56%), Positives = 34/53 (64%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            EE E E EEEEGE E EEE E + EE   E + EE+ EE   EGE+EEG  EG
Sbjct: 889  EEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941



 Score = 53.9 bits (128), Expect = 4e-06
 Identities = 30/53 (56%), Positives = 34/53 (64%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            E EEEE E E  EEE E E EE+ E   +E E E +EEE   EGE+EEG EEG
Sbjct: 947  EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEG 999



 Score = 53.9 bits (128), Expect = 4e-06
 Identities = 32/62 (51%), Positives = 42/62 (67%), Gaps = 2/62 (3%)

Query: 1866 IEPEVFTEEEEEEDEEEEGEEEDEE-EKEEDEEETAQEKEDEEKEEEEAAE-GEKEEGLE 1923
            +E EV  EE E E EEEEGEEE EE EKE + EE  + +E+EE+EE +  E GE+E   +
Sbjct: 1021 VEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQ 1080

Query: 1924 EG 1925
            +G
Sbjct: 1081 DG 1082



 Score = 53.5 bits (127), Expect = 5e-06
 Identities = 33/63 (52%), Positives = 38/63 (60%), Gaps = 4/63 (6%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEE----DEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGL 1922
            E E   EE E E+EE EGEEE    +EEE E   EE  +E E EE+ EE   EGE+EEG 
Sbjct: 825  EREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGE 884

Query: 1923 EEG 1925
             EG
Sbjct: 885  GEG 887



 Score = 53.5 bits (127), Expect = 5e-06
 Identities = 35/62 (56%), Positives = 39/62 (62%), Gaps = 4/62 (6%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDE-EETAQEKEDEEKEEEEAAEGEKE---EGL 1922
            E E   EEEE E EEEEGE + EEE EE E EE  +E E E +EEE   EGE+E   EG 
Sbjct: 837  EEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE 896

Query: 1923 EE 1924
            EE
Sbjct: 897  EE 898



 Score = 52.4 bits (124), Expect = 1e-05
 Identities = 33/71 (46%), Positives = 42/71 (59%)

Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
            G+E+ ++     E E    E EEE+ E EGEEE E E EE+E E   E+E E + EEE  
Sbjct: 858  GEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 917

Query: 1915 EGEKEEGLEEG 1925
            EG+ EE  EEG
Sbjct: 918  EGKGEEEGEEG 928



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 32/67 (47%), Positives = 43/67 (64%), Gaps = 9/67 (13%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEK--------EEDEEETAQEKEDEEKEEEEAAEGEK 1918
            E E   EEE  E EEEEG+ E+EEEK        E +E E  +EKE+ E+++EE A G++
Sbjct: 726  EMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERA-GKE 784

Query: 1919 EEGLEEG 1925
            E+G EEG
Sbjct: 785  EKGEEEG 791



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 30/53 (56%), Positives = 35/53 (66%), Gaps = 1/53 (1%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            EE E E EE EGE E+EE + E EEE  +E+ +EE E EE  EGE EE  EEG
Sbjct: 968  EEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEE-EEG 1019



 Score = 51.2 bits (121), Expect = 3e-05
 Identities = 29/59 (49%), Positives = 37/59 (62%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            E E   E E  E EE +GE E+EEE+ E EEE  + +E+E + EEE  EG+ EE  EEG
Sbjct: 807  EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEG 865



 Score = 51.2 bits (121), Expect = 3e-05
 Identities = 31/56 (55%), Positives = 35/56 (62%), Gaps = 3/56 (5%)

Query: 1873 EEEEEEDEEEEGEEEDEE---EKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            EE E E EEEEGE E E+   E EE+E E   E+E+ E E EE  EGE EEG  EG
Sbjct: 926  EEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG 981



 Score = 50.4 bits (119), Expect = 4e-05
 Identities = 27/59 (45%), Positives = 38/59 (64%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            E E   EE+EE  E E GE E+ + + E+EEE  + +E+E + EEE  EGE+EEG  +G
Sbjct: 800  ETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKG 858



 Score = 50.1 bits (118), Expect = 6e-05
 Identities = 30/58 (51%), Positives = 36/58 (62%), Gaps = 5/58 (8%)

Query: 1873 EEEEEEDEEEEGEEEDEEEK-----EEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            EEEE E E E+GE E EEE+     EE+E E   E+E E + EE   EGE+EEG  EG
Sbjct: 933  EEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEG 990



 Score = 49.7 bits (117), Expect = 7e-05
 Identities = 29/53 (54%), Positives = 32/53 (60%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            EEE E + EEEGE E EEE+ E E E   E E EE+E E   E E EEG  EG
Sbjct: 880  EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEG 932



 Score = 49.7 bits (117), Expect = 7e-05
 Identities = 34/63 (53%), Positives = 38/63 (60%), Gaps = 4/63 (6%)

Query: 1867 EPEVFTEEEEEEDE-EEEGEEEDEEEKEEDEEETAQEKEDEEKE---EEEAAEGEKEEGL 1922
            E E   E E EE+E E EGEEE E E EE+E E   E+E EE E   EEE  EGE E+G 
Sbjct: 886  EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGE 945

Query: 1923 EEG 1925
             EG
Sbjct: 946  GEG 948



 Score = 49.7 bits (117), Expect = 7e-05
 Identities = 31/62 (50%), Positives = 38/62 (61%), Gaps = 3/62 (4%)

Query: 1867 EPEVFTEEEEEEDE---EEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLE 1923
            E E   E EEEE E   EEEGEE + E +EE+ E   ++ E E +EEE   EGE+EEG  
Sbjct: 905  EEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEG 964

Query: 1924 EG 1925
            EG
Sbjct: 965  EG 966



 Score = 49.3 bits (116), Expect = 1e-04
 Identities = 31/54 (57%), Positives = 36/54 (66%), Gaps = 2/54 (3%)

Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEA-AEGEKE-EGLEEG 1925
            E EEE+ E EGEEE E E EE E E  +E+ + E EEEE   EGE+E EG EEG
Sbjct: 956  EGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEG 1009



 Score = 49.3 bits (116), Expect = 1e-04
 Identities = 32/55 (58%), Positives = 36/55 (65%), Gaps = 2/55 (3%)

Query: 1873 EEEEEEDEEEEGEEEDEE-EKEEDEEETAQEKEDEEKEEEEAAEGE-KEEGLEEG 1925
            EEE E + EEEGE E EE E E +EEE   E E+EE EEE   EGE +EEG  EG
Sbjct: 959  EEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEG 1013



 Score = 49.3 bits (116), Expect = 1e-04
 Identities = 29/59 (49%), Positives = 35/59 (59%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            E E   EEE E +EE EGE E+EEE E + E   +E E E +EEE   EGE+ E   EG
Sbjct: 994  EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052



 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 44/147 (29%), Positives = 62/147 (42%), Gaps = 8/147 (5%)

Query: 4394 EQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGG 4453
            E+  G G + +GEG  E  G+  EG G+EEE   E   G  +G     + G +  E   G
Sbjct: 906  EEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGE---EEEGEWEGEEEEG 962

Query: 4454 LGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEE 4513
             G+  +    E    EG    +   G +G EEE     E E E E E E+     GE+EE
Sbjct: 963  EGEGEEEGEGEGEEGEGEGEEEEGEG-EGEEEE----GEEEGEEEGEGEEEGEGEGEEEE 1017

Query: 4514 VPEPTPEPPKKQAPPSPPPKKEEAGGE 4540
              E   E   ++       ++ E  GE
Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGE 1044



 Score = 48.5 bits (114), Expect = 2e-04
 Identities = 32/64 (50%), Positives = 37/64 (57%), Gaps = 5/64 (7%)

Query: 1867 EPEVFTEEEEEED----EEEEGEE-EDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
            E E   EEEEE++    EE EGEE E E EKEE E +  +    EEK EEE  +GE EE 
Sbjct: 740  EEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEE 799

Query: 1922 LEEG 1925
              EG
Sbjct: 800  ETEG 803



 Score = 48.5 bits (114), Expect = 2e-04
 Identities = 30/59 (50%), Positives = 33/59 (55%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            E E    E EEE E E  EEE E E EE+ E   +E+E E K EEE  EGE E   EEG
Sbjct: 879  EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEG 937



 Score = 48.5 bits (114), Expect = 2e-04
 Identities = 28/53 (52%), Positives = 35/53 (66%), Gaps = 1/53 (1%)

Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGE-KEEGLEEG 1925
            EEE E+ E EGEEE+ E + ED E   +E+E E + EEE  EGE +EEG  EG
Sbjct: 922  EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEG 974



 Score = 48.1 bits (113), Expect = 2e-04
 Identities = 68/268 (25%), Positives = 92/268 (34%), Gaps = 48/268 (17%)

Query: 4365 GGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEE 4424
            GG VE  K     E   G  +   +E  GE+  G G + +GEG  E  G+  EG  + EE
Sbjct: 816  GGEVEEGKGEREEEEEEG--EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEE 873

Query: 4425 AVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGV-DGV 4483
               E      +G       G    E   G G+       E    EG    + + G  +G 
Sbjct: 874  GEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGE 933

Query: 4484 EEELPPEPE------PEPEPELEPEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEA 4537
            EEE   E E       E E E E E+ + E   +EE      E   +        + EE 
Sbjct: 934  EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE 993

Query: 4538 GGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSA 4597
             GE  GE E +                                 +      GE++ EG  
Sbjct: 994  EGEEEGEEEGEG--------------------------------EEEGEGEGEEEEEGEV 1021

Query: 4598 AGDVSGAGSGGSSGWGLGAGEEAEGDED 4625
             G+V G         G G GEE EG+E+
Sbjct: 1022 EGEVEGEE-------GEGEGEEEEGEEE 1042



 Score = 47.8 bits (112), Expect = 3e-04
 Identities = 25/49 (51%), Positives = 31/49 (63%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
            +E EE  EEE GE E+EE   E+EEE   E ++E + EE   E EKEEG
Sbjct: 725  QEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEG 773



 Score = 47.8 bits (112), Expect = 3e-04
 Identities = 25/56 (44%), Positives = 36/56 (64%), Gaps = 7/56 (12%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEE-------TAQEKEDEEKEEEEAAEGEKEEG 1921
            E+ EEE ++ EGEEE+ E + E++EE         +E + E +EEEE  EGE+EEG
Sbjct: 785  EKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG 840



 Score = 47.8 bits (112), Expect = 3e-04
 Identities = 65/247 (26%), Positives = 87/247 (35%), Gaps = 50/247 (20%)

Query: 4389 DEVHGEQPAGPG-GDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFR 4447
            D+  GE+    G G+   EG     G+  EG G+ EE   E      +G     +G    
Sbjct: 792  DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE 851

Query: 4448 PEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAE 4507
             EG G   + G+    E    EG          +G EEE   E E E E E E E+ +  
Sbjct: 852  EEGEGKGEEEGEEGEGEEEGEEGEG--------EGEEEEGEGEGEEEGEGEGEEEEGE-- 901

Query: 4508 NGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLA 4567
             GE EE  E   E  + +       K EE G E  GE E +  +                
Sbjct: 902  -GEGEEEGEGEGEEEEGEG------KGEEEGEEGEGEGEEEEGEGEGEDGEG-------- 946

Query: 4568 LFLAFAINFILLFYKVSDSPPGE---DDMEGSAAGDVSGAGSG------GSSGWGLGAGE 4618
                             +   GE   ++ EG   G+  G G G      G    G G GE
Sbjct: 947  ---------------EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGE 991

Query: 4619 EAEGDED 4625
            E EG+E+
Sbjct: 992  EEEGEEE 998



 Score = 47.8 bits (112), Expect = 3e-04
 Identities = 29/58 (50%), Positives = 34/58 (58%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
            E EV  E E EE E E  EEE EEE EE E+E   E+    +EEEE  EG+ +E  EE
Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEE 1075



 Score = 47.4 bits (111), Expect = 4e-04
 Identities = 28/59 (47%), Positives = 35/59 (59%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            E E   E EEE + EEEGE E EEE+E + E   + +E E + EEE  E E EE  +EG
Sbjct: 992  EEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEG 1050



 Score = 47.0 bits (110), Expect = 5e-04
 Identities = 29/82 (35%), Positives = 46/82 (56%), Gaps = 1/82 (1%)

Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
            +E+  ++   +E E    E EEE+ EEEGEE ++E + E+     +E+E+EE + +E  E
Sbjct: 1015 EEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGE 1074

Query: 1916 GEKE-EGLEEGLLQMKLPESVK 1936
             E E +  EE     K+  SVK
Sbjct: 1075 EENERQDGEEYKKVSKIKGSVK 1096



 Score = 46.2 bits (108), Expect = 8e-04
 Identities = 28/60 (46%), Positives = 35/60 (58%), Gaps = 1/60 (1%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEE-EKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            E E   ++E  ++ EE GEEE  E E+EE + E  +EKE E KEE E  E E E   EEG
Sbjct: 714  EREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEG 773



 Score = 46.2 bits (108), Expect = 8e-04
 Identities = 29/65 (44%), Positives = 37/65 (56%), Gaps = 3/65 (4%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEK---EEGLE 1923
            E E   E EEEE+ E EGE E EE + E EEE  +E+ +E ++E E  E  +   EE  E
Sbjct: 1006 EEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEE 1065

Query: 1924 EGLLQ 1928
            EG  Q
Sbjct: 1066 EGKYQ 1070



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 25/53 (47%), Positives = 33/53 (62%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            E E EE+ E EGEEE+ E K E+E E  + + +EE+ E E  +GE E   EEG
Sbjct: 901  EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEG 953



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 29/61 (47%), Positives = 35/61 (57%), Gaps = 9/61 (14%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEE---------ETAQEKEDEEKEEEEAAEGEKEEGLE 1923
            E EEE +EE EGEEE E E EE+EE         E  + + +EE+ EEE  E EKE   E
Sbjct: 994  EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGE 1053

Query: 1924 E 1924
            E
Sbjct: 1054 E 1054



 Score = 45.1 bits (105), Expect = 0.002
 Identities = 29/73 (39%), Positives = 38/73 (52%), Gaps = 9/73 (12%)

Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEG---------EEEDEEEKEEDEEETAQEKEDEE 1907
            E  K++ +  E +    EE+E+ E E+G         EE  EEE  E EEE    +E+EE
Sbjct: 691  EGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEE 750

Query: 1908 KEEEEAAEGEKEE 1920
            KE E   EGE EE
Sbjct: 751  KEGEGKEEGEGEE 763



 Score = 45.1 bits (105), Expect = 0.002
 Identities = 63/233 (27%), Positives = 79/233 (33%), Gaps = 50/233 (21%)

Query: 4406 EGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEG-------AGGL---G 4455
            EG  E  G+  E  GD EE   + G G  +G     +G   + EG       AG      
Sbjct: 729  EGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGE 788

Query: 4456 DMGDTTPAEPPTPEGSPILKRKLG-VDGVEEELPPEPEPEPEPELEPEKADAENGEKEEV 4514
            + GD    E    EG    K + G V+G E E       E E E E E+ + E GE+EE 
Sbjct: 789  EEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE-GEEEEG 847

Query: 4515 PEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAI 4574
                 E   K        + EE G E  GE E                            
Sbjct: 848  EGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE---------------------------- 879

Query: 4575 NFILLFYKVSDSPPGEDDMEGSAAG-DVSGAGSGGSSGWGLGAGEEAEGDEDE 4626
                      +   GE + EG   G +  G G G   G G G  EE EG  +E
Sbjct: 880  ---------EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEE 923



 Score = 45.1 bits (105), Expect = 0.002
 Identities = 36/69 (52%), Positives = 41/69 (59%), Gaps = 10/69 (14%)

Query: 1867 EPEVFTEEEE-----EEDEEE-EGEEEDEE---EKEEDEEETAQEKEDEEKEEEEAAEGE 1917
            E E   EEEE     EE+ EE EGEEE EE   E EE+E E   E+E E + EEE  EGE
Sbjct: 844  EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGE 903

Query: 1918 -KEEGLEEG 1925
             +EEG  EG
Sbjct: 904  GEEEGEGEG 912



 Score = 44.3 bits (103), Expect = 0.003
 Identities = 26/56 (46%), Positives = 34/56 (60%), Gaps = 4/56 (7%)

Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKED----EEKEEEEAAEGEKEEGLEE 1924
            E E+E  E+EE ++ D EE+E+ E E   +KE     EE  EEE  EGE+EEG  E
Sbjct: 691  EGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDRE 746



 Score = 43.9 bits (102), Expect = 0.004
 Identities = 30/59 (50%), Positives = 36/59 (61%), Gaps = 2/59 (3%)

Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
            E E   E E E  EEEEGE + EEE EE E E  +E+E E + E+   EGE+EEG  EG
Sbjct: 901  EGEGEEEGEGE-GEEEEGEGKGEEEGEEGEGE-GEEEEGEGEGEDGEGEGEEEEGEWEG 957



 Score = 42.4 bits (98), Expect = 0.012
 Identities = 27/58 (46%), Positives = 34/58 (58%), Gaps = 8/58 (13%)

Query: 1874 EEEEEDEEEEGEEEDEE-----EKEEDEEETAQEKEDEEKEEEEAAEG---EKEEGLE 1923
            +EE E EE EGE E EE     E+   +EE  +E+ D+ + EEE  EG   EKEEG E
Sbjct: 756  KEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGE 813



 Score = 42.0 bits (97), Expect = 0.015
 Identities = 24/62 (38%), Positives = 37/62 (59%), Gaps = 1/62 (1%)

Query: 1860 KQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKE 1919
            K+  K  + E   ++E E+  ++E  +E EE  EE+  E  +E+ D E+EEE+  EG KE
Sbjct: 699  KEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEG-KE 757

Query: 1920 EG 1921
            EG
Sbjct: 758  EG 759



 Score = 40.8 bits (94), Expect = 0.034
 Identities = 47/155 (30%), Positives = 62/155 (40%), Gaps = 12/155 (7%)

Query: 4364 GGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGG----DADGEGASEGAGDAAEGA 4419
            G G  EG +     E   G  +    E  GE+  G       + +GEG  EG G+  EG 
Sbjct: 919  GKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGE 978

Query: 4420 GDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLG 4479
            G+ EE   E G G  +      +G     EG G     G+    E    EG    +   G
Sbjct: 979  GEGEE---EEGEGEGEEEEGEEEG---EEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEG 1032

Query: 4480 VDGVEEELPPE-PEPEPEPELEPEKADAENGEKEE 4513
             +G EEE   E  E E E E E  + + E  E+EE
Sbjct: 1033 -EGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066



 Score = 40.0 bits (92), Expect = 0.059
 Identities = 24/66 (36%), Positives = 39/66 (59%), Gaps = 5/66 (7%)

Query: 1864 KMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKE---- 1919
            ++ E E + + + EE E++E E+  ++E+ ++ EE  +E E  E EEEE    E+E    
Sbjct: 695  ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEE-EHGEGEEEEGDREEEEEKEG 753

Query: 1920 EGLEEG 1925
            EG EEG
Sbjct: 754  EGKEEG 759



 Score = 38.5 bits (88), Expect = 0.17
 Identities = 22/64 (34%), Positives = 40/64 (62%), Gaps = 7/64 (10%)

Query: 1869 EVFTEEEEEEDEEEEG----EEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG---EKEEG 1921
            E + +EE E+ E+++G    E   E EKE  E+E  ++++ EE+E++E  +G   E+ + 
Sbjct: 667  EHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQE 726

Query: 1922 LEEG 1925
            +EEG
Sbjct: 727  MEEG 730



 Score = 33.5 bits (75), Expect = 5.5
 Identities = 30/118 (25%), Positives = 46/118 (38%), Gaps = 5/118 (4%)

Query: 1793 EAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMG 1852
            E   +LSP       + K  + +GE  +D      D      E   +   K     +  G
Sbjct: 512  EKSLKLSPV-----QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQG 566

Query: 1853 IFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
            IF  +    I    + EV   EE+E  E+ +G   +E+E E +EE        +EK E
Sbjct: 567  IFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTE 624



 Score = 32.7 bits (73), Expect = 9.4
 Identities = 35/135 (25%), Positives = 53/135 (39%), Gaps = 5/135 (3%)

Query: 4406 EGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAEP 4465
            EG ++  G+A +G     +   E G  GA+      D    + E   G G+M      E 
Sbjct: 638  EGKAKSVGEAEDGPEGRGDGTCEEGSSGAE---HWQDEEREKGEKDKGRGEMERPGEGEK 694

Query: 4466 PTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEPPKKQ 4525
               E     KR  G +  ++E     + E   E+E E  + E+GE EE      E  +K+
Sbjct: 695  ELAEKEEWKKRD-GEEQEQKEREQGHQKERNQEME-EGGEEEHGEGEEEEGDREEEEEKE 752

Query: 4526 APPSPPPKKEEAGGE 4540
                   + EE  GE
Sbjct: 753  GEGKEEGEGEEVEGE 767


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 208,535,304
Number of Sequences: 37866
Number of extensions: 10791165
Number of successful extensions: 144652
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 866
Number of HSP's successfully gapped in prelim test: 970
Number of HSP's that attempted gapping in prelim test: 66469
Number of HSP's gapped (non-prelim): 42813
length of query: 5038
length of database: 18,247,518
effective HSP length: 124
effective length of query: 4914
effective length of database: 13,552,134
effective search space: 66595186476
effective search space used: 66595186476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 73 (32.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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