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Search of human proteins with 154277116
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154277116 spectrin repeat containing, nuclear envelope 1
isoform 1 [Homo sapiens]
(8797 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 1.717e+04 0.0
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 1.684e+04 0.0
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof... 6481 0.0
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 2051 0.0
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 2049 0.0
gi|154277120 spectrin repeat containing, nuclear envelope 1 isof... 1890 0.0
gi|221316624 dystonin isoform 4 [Homo sapiens] 372 e-102
gi|221316622 dystonin isoform 3 [Homo sapiens] 372 e-102
gi|221316618 dystonin isoform 2 [Homo sapiens] 372 e-102
gi|34577047 dystonin isoform 1 [Homo sapiens] 372 e-102
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 372 e-102
gi|33188445 microfilament and actin filament cross-linker protei... 354 2e-96
gi|33188443 microfilament and actin filament cross-linker protei... 340 5e-92
gi|33624873 spectrin repeat containing, nuclear envelope 2 isofo... 337 4e-91
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 317 4e-85
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens] 315 1e-84
gi|5032283 dystrophin Dp427m isoform [Homo sapiens] 313 6e-84
gi|33624861 spectrin repeat containing, nuclear envelope 2 isofo... 309 9e-83
gi|110611228 utrophin [Homo sapiens] 296 5e-79
gi|145580592 nesprin-3 [Homo sapiens] 285 1e-75
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 273 5e-72
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 270 4e-71
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 270 5e-71
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 269 8e-71
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 268 1e-70
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 268 2e-70
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 267 3e-70
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 267 3e-70
gi|19923599 calmin [Homo sapiens] 265 1e-69
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 244 3e-63
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 1.717e+04 bits (44571), Expect = 0.0
Identities = 8797/8797 (100%), Positives = 8797/8797 (100%)
Query: 1 MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60
MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG
Sbjct: 1 MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60
Query: 61 VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS 120
VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS
Sbjct: 61 VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS 120
Query: 121 IVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNA 180
IVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNA
Sbjct: 121 IVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNA 180
Query: 181 KKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLE 240
KKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLE
Sbjct: 181 KKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLE 240
Query: 241 DAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILP 300
DAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILP
Sbjct: 241 DAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILP 300
Query: 301 GFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEM 360
GFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEM
Sbjct: 301 GFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEM 360
Query: 361 KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYR 420
KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYR
Sbjct: 361 KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYR 420
Query: 421 AEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD 480
AEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD
Sbjct: 421 AEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD 480
Query: 481 QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLL 540
QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLL
Sbjct: 481 QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLL 540
Query: 541 QNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE 600
QNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE
Sbjct: 541 QNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE 600
Query: 601 VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 660
VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM
Sbjct: 601 VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 660
Query: 661 NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTL 720
NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTL
Sbjct: 661 NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTL 720
Query: 721 SAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE 780
SAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE
Sbjct: 721 SAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE 780
Query: 781 EGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITV 840
EGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITV
Sbjct: 781 EGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITV 840
Query: 841 LEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQ 900
LEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQ
Sbjct: 841 LEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQ 900
Query: 901 IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELL 960
IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELL
Sbjct: 901 IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELL 960
Query: 961 RRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLL 1020
RRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLL
Sbjct: 961 RRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLL 1020
Query: 1021 HLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQL 1080
HLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQL
Sbjct: 1021 HLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQL 1080
Query: 1081 IEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWI 1140
IEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWI
Sbjct: 1081 IEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWI 1140
Query: 1141 STNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEA 1200
STNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEA
Sbjct: 1141 STNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEA 1200
Query: 1201 QKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAE 1260
QKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAE
Sbjct: 1201 QKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAE 1260
Query: 1261 KILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLEST 1320
KILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLEST
Sbjct: 1261 KILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLEST 1320
Query: 1321 LDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE 1380
LDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE
Sbjct: 1321 LDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE 1380
Query: 1381 QTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKT 1440
QTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKT
Sbjct: 1381 QTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKT 1440
Query: 1441 MEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI 1500
MEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI
Sbjct: 1441 MEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI 1500
Query: 1501 VGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEEN 1560
VGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEEN
Sbjct: 1501 VGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEEN 1560
Query: 1561 LRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVV 1620
LRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVV
Sbjct: 1561 LRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVV 1620
Query: 1621 NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASS 1680
NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASS
Sbjct: 1621 NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASS 1680
Query: 1681 PEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLE 1740
PEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLE
Sbjct: 1681 PEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLE 1740
Query: 1741 QLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ 1800
QLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ
Sbjct: 1741 QLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ 1800
Query: 1801 VALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVV 1860
VALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVV
Sbjct: 1801 VALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVV 1860
Query: 1861 ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE 1920
ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE
Sbjct: 1861 ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE 1920
Query: 1921 SAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLK 1980
SAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLK
Sbjct: 1921 SAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLK 1980
Query: 1981 KAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2040
KAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD
Sbjct: 1981 KAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2040
Query: 2041 KAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSK 2100
KAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSK
Sbjct: 2041 KAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSK 2100
Query: 2101 VLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2160
VLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH
Sbjct: 2101 VLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2160
Query: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2220
SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM
Sbjct: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2220
Query: 2221 AENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEAD 2280
AENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEAD
Sbjct: 2221 AENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEAD 2280
Query: 2281 LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALK 2340
LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALK
Sbjct: 2281 LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALK 2340
Query: 2341 KVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQ 2400
KVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQ
Sbjct: 2341 KVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQ 2400
Query: 2401 ASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
ASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ
Sbjct: 2401 ASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
Query: 2461 SKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSF 2520
SKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSF
Sbjct: 2461 SKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSF 2520
Query: 2521 EDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQR 2580
EDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQR
Sbjct: 2521 EDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQR 2580
Query: 2581 GQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV 2640
GQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV
Sbjct: 2581 GQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV 2640
Query: 2641 KAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ 2700
KAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ
Sbjct: 2641 KAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ 2700
Query: 2701 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2760
RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL
Sbjct: 2701 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2760
Query: 2761 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2820
QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ
Sbjct: 2761 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2820
Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL
Sbjct: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT
Sbjct: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWH 3000
QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWH
Sbjct: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWH 3000
Query: 3001 KGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN 3060
KGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN
Sbjct: 3001 KGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN 3060
Query: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3120
KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK
Sbjct: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3120
Query: 3121 LNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEV 3180
LNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEV
Sbjct: 3121 LNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEV 3180
Query: 3181 SAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL 3240
SAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL
Sbjct: 3181 SAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL 3240
Query: 3241 WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI 3300
WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI
Sbjct: 3241 WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI 3300
Query: 3301 HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ 3360
HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ
Sbjct: 3301 HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ 3360
Query: 3361 QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA 3420
QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA
Sbjct: 3361 QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA 3420
Query: 3421 ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA 3480
ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA
Sbjct: 3421 ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA 3480
Query: 3481 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQV 3540
KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQV
Sbjct: 3481 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQV 3540
Query: 3541 HCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL 3600
HCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL
Sbjct: 3541 HCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL 3600
Query: 3601 RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA 3660
RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA
Sbjct: 3601 RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA 3660
Query: 3661 RAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3720
RAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW
Sbjct: 3661 RAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3720
Query: 3721 YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE 3780
YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE
Sbjct: 3721 YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE 3780
Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH
Sbjct: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ 3900
VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ
Sbjct: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ 3900
Query: 3901 SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT 3960
SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT
Sbjct: 3901 SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT 3960
Query: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 4020
QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI
Sbjct: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 4020
Query: 4021 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4080
CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR
Sbjct: 4021 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4080
Query: 4081 ALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKS 4140
ALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKS
Sbjct: 4081 ALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKS 4140
Query: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLT 4200
ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLT
Sbjct: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLT 4200
Query: 4201 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4260
KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW
Sbjct: 4201 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4260
Query: 4261 DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSH 4320
DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSH
Sbjct: 4261 DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSH 4320
Query: 4321 LEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMA 4380
LEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMA
Sbjct: 4321 LEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMA 4380
Query: 4381 QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDL 4440
QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDL
Sbjct: 4381 QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDL 4440
Query: 4441 VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQ 4500
VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQ
Sbjct: 4441 VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQ 4500
Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4560
ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN
Sbjct: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4560
Query: 4561 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4620
LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL
Sbjct: 4561 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4620
Query: 4621 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4680
TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI
Sbjct: 4621 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4680
Query: 4681 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF
Sbjct: 4681 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
Query: 4741 RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE 4800
RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE
Sbjct: 4741 RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE 4800
Query: 4801 QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS 4860
QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS
Sbjct: 4801 QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS 4860
Query: 4861 WQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI 4920
WQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI
Sbjct: 4861 WQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI 4920
Query: 4921 QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA 4980
QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA
Sbjct: 4921 QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA 4980
Query: 4981 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFS 5040
LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFS
Sbjct: 4981 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFS 5040
Query: 5041 TEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCT 5100
TEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCT
Sbjct: 5041 TEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCT 5100
Query: 5101 AQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIV 5160
AQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIV
Sbjct: 5101 AQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIV 5160
Query: 5161 ALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKV 5220
ALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKV
Sbjct: 5161 ALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKV 5220
Query: 5221 KKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ 5280
KKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ
Sbjct: 5221 KKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ 5280
Query: 5281 DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ 5340
DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ
Sbjct: 5281 DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ 5340
Query: 5341 ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQL 5400
ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQL
Sbjct: 5341 ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQL 5400
Query: 5401 AEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKT 5460
AEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKT
Sbjct: 5401 AEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKT 5460
Query: 5461 DQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS 5520
DQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS
Sbjct: 5461 DQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS 5520
Query: 5521 KLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID 5580
KLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID
Sbjct: 5521 KLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID 5580
Query: 5581 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5640
SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE
Sbjct: 5581 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5640
Query: 5641 LKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPE 5700
LKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPE
Sbjct: 5641 LKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPE 5700
Query: 5701 DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHRE 5760
DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHRE
Sbjct: 5701 DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHRE 5760
Query: 5761 IEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5820
IEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE
Sbjct: 5761 IEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5820
Query: 5821 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 5880
VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR
Sbjct: 5821 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 5880
Query: 5881 SPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL 5940
SPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL
Sbjct: 5881 SPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL 5940
Query: 5941 QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQM 6000
QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQM
Sbjct: 5941 QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQM 6000
Query: 6001 AEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMK 6060
AEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMK
Sbjct: 6001 AEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMK 6060
Query: 6061 ASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDME 6120
ASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDME
Sbjct: 6061 ASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDME 6120
Query: 6121 AQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ 6180
AQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ
Sbjct: 6121 AQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ 6180
Query: 6181 RALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQE 6240
RALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQE
Sbjct: 6181 RALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQE 6240
Query: 6241 LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE 6300
LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE
Sbjct: 6241 LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE 6300
Query: 6301 SLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQ 6360
SLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQ
Sbjct: 6301 SLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQ 6360
Query: 6361 AFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQE 6420
AFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQE
Sbjct: 6361 AFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQE 6420
Query: 6421 ILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMK 6480
ILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMK
Sbjct: 6421 ILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMK 6480
Query: 6481 ERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGI 6540
ERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGI
Sbjct: 6481 ERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGI 6540
Query: 6541 IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6600
IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD
Sbjct: 6541 IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6600
Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET
Sbjct: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE
Sbjct: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT
Sbjct: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN
Sbjct: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE 6900
AFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE
Sbjct: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE 6900
Query: 6901 KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI
Sbjct: 6901 KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL
Sbjct: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
Query: 7021 LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEK 7080
LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEK
Sbjct: 7021 LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEK 7080
Query: 7081 IEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFD 7140
IEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFD
Sbjct: 7081 IEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFD 7140
Query: 7141 KINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE 7200
KINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE
Sbjct: 7141 KINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE 7200
Query: 7201 CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED
Sbjct: 7201 CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS
Sbjct: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP
Sbjct: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLI 7440
SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLI
Sbjct: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLI 7440
Query: 7441 SSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF 7500
SSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF
Sbjct: 7441 SSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF 7500
Query: 7501 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7560
QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS
Sbjct: 7501 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7560
Query: 7561 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGS 7620
QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGS
Sbjct: 7561 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGS 7620
Query: 7621 YILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEK 7680
YILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEK
Sbjct: 7621 YILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEK 7680
Query: 7681 GIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 7740
GIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA
Sbjct: 7681 GIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 7740
Query: 7741 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 7800
YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME
Sbjct: 7741 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 7800
Query: 7801 SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7860
SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG
Sbjct: 7801 SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7860
Query: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE
Sbjct: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
Query: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW
Sbjct: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
Query: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK 8040
RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK
Sbjct: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK 8040
Query: 8041 KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL 8100
KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL
Sbjct: 8041 KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL 8100
Query: 8101 RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH 8160
RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH
Sbjct: 8101 RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH 8160
Query: 8161 NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH 8220
NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH
Sbjct: 8161 NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH 8220
Query: 8221 DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS
Sbjct: 8221 DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGK 8340
IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGK
Sbjct: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGK 8340
Query: 8341 ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 8400
ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES
Sbjct: 8341 ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 8400
Query: 8401 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 8460
LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE
Sbjct: 8401 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 8460
Query: 8461 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 8520
EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL
Sbjct: 8461 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 8520
Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID
Sbjct: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN
Sbjct: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
Query: 8641 RLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPR 8700
RLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPR
Sbjct: 8641 RLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPR 8700
Query: 8701 GKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIG 8760
GKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIG
Sbjct: 8701 GKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIG 8760
Query: 8761 LACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL 8797
LACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL
Sbjct: 8761 LACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL 8797
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 1.684e+04 bits (43712), Expect = 0.0
Identities = 8669/8828 (98%), Positives = 8685/8828 (98%), Gaps = 110/8828 (1%)
Query: 1 MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60
MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG
Sbjct: 1 MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60
Query: 61 VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRK-------IKLVNINSTD 113
VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRK IKLVNINSTD
Sbjct: 61 VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTD 120
Query: 114 IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT 173
IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT
Sbjct: 121 IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT 180
Query: 174 TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR 233
TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR
Sbjct: 181 TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR 240
Query: 234 SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ 293
SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ
Sbjct: 241 SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ 300
Query: 294 EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH 353
EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH
Sbjct: 301 EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH 360
Query: 354 FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT 413
FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT
Sbjct: 361 FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT 420
Query: 414 IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN 473
IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN
Sbjct: 421 IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN 480
Query: 474 GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR 533
GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR
Sbjct: 481 GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR 540
Query: 534 ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ 593
ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ
Sbjct: 541 ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ 600
Query: 594 WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW 653
WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW
Sbjct: 601 WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW 660
Query: 654 IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY 713
IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY
Sbjct: 661 IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY 720
Query: 714 TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI 773
TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI
Sbjct: 721 TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI 780
Query: 774 TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK 833
TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK
Sbjct: 781 TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK 840
Query: 834 INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD 893
INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD
Sbjct: 841 INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD 900
Query: 894 QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK 953
QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK
Sbjct: 901 QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK 960
Query: 954 GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG 1013
GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG
Sbjct: 961 GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG 1020
Query: 1014 EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL 1073
EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL
Sbjct: 1021 EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL 1080
Query: 1074 CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF 1133
CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF
Sbjct: 1081 CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF 1140
Query: 1134 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE
Sbjct: 1141 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1200
Query: 1194 VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK 1253
VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK
Sbjct: 1201 VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK 1260
Query: 1254 EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE 1313
EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE
Sbjct: 1261 EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE 1320
Query: 1314 LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE 1373
LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE
Sbjct: 1321 LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE 1380
Query: 1374 SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT 1433
SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT
Sbjct: 1381 SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT 1440
Query: 1434 LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI 1493
LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI
Sbjct: 1441 LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI 1500
Query: 1494 ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ 1553
ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ
Sbjct: 1501 ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ 1560
Query: 1554 QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS 1613
QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS
Sbjct: 1561 QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS 1620
Query: 1614 ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER 1673
ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER
Sbjct: 1621 ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER 1680
Query: 1674 GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK 1733
GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK
Sbjct: 1681 GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK 1740
Query: 1734 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1793
MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE
Sbjct: 1741 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1800
Query: 1794 ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF 1853
ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF
Sbjct: 1801 ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF 1860
Query: 1854 EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL 1913
EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL
Sbjct: 1861 EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL 1920
Query: 1914 QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA 1973
QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA
Sbjct: 1921 QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA 1980
Query: 1974 DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH 2033
DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH
Sbjct: 1981 DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH 2040
Query: 2034 ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN 2093
ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN
Sbjct: 2041 ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN 2100
Query: 2094 LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL
Sbjct: 2101 LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2160
Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS
Sbjct: 2161 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2220
Query: 2214 NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD 2273
NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD
Sbjct: 2221 NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD 2280
Query: 2274 LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN 2333
LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN
Sbjct: 2281 LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN 2340
Query: 2334 ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2393
ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS
Sbjct: 2341 ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2400
Query: 2394 QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2453
QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL
Sbjct: 2401 QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2460
Query: 2454 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC 2513
DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC
Sbjct: 2461 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC 2520
Query: 2514 ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2573
ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES
Sbjct: 2521 ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2580
Query: 2574 LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL 2633
LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL
Sbjct: 2581 LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL 2640
Query: 2634 QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR 2693
QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR
Sbjct: 2641 QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR 2700
Query: 2694 SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD 2753
SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD
Sbjct: 2701 SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD 2760
Query: 2754 QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA 2813
QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA
Sbjct: 2761 QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA 2820
Query: 2814 QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS 2873
QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS
Sbjct: 2821 QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS 2880
Query: 2874 SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW 2933
SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW
Sbjct: 2881 SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW 2940
Query: 2934 EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE 2993
EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE
Sbjct: 2941 EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE 3000
Query: 2994 EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ 3053
EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ
Sbjct: 3001 EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ 3060
Query: 3054 ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE 3113
ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE
Sbjct: 3061 ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE 3120
Query: 3114 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3173
SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI
Sbjct: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
Query: 3174 QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL 3233
QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL
Sbjct: 3181 QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL 3240
Query: 3234 KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ 3293
KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ
Sbjct: 3241 KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ 3300
Query: 3294 DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP 3353
DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP
Sbjct: 3301 DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP 3360
Query: 3354 EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN 3413
EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN
Sbjct: 3361 EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN 3420
Query: 3414 ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY 3473
ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY
Sbjct: 3421 ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY 3480
Query: 3474 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3533
RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR
Sbjct: 3481 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3540
Query: 3534 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3593
DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF
Sbjct: 3541 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3600
Query: 3594 NNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
NNVVNKLRLMEQKFQQVDEWLKTAEEK KWHEEVTAYRD
Sbjct: 3601 NNVVNKLRLMEQKFQQVDEWLKTAEEK----------------------KWHEEVTAYRD 3638
Query: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS
Sbjct: 3639 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3698
Query: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER
Sbjct: 3699 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3758
Query: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833
AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA
Sbjct: 3759 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3818
Query: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLK 3893
EYQEILHVPE EP ++ +K +
Sbjct: 3819 EYQEILHVPE--------------------------EPKMELYEKKAQL----------- 3841
Query: 3894 DKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLET 3953
S Y+ SL+ V HE ++E + LL++ + D ++
Sbjct: 3842 -------SKYK-----------SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKID- 3882
Query: 3954 SSLETITQQLAH-HKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG 4012
L++ Q L KAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG
Sbjct: 3883 -QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG 3941
Query: 4013 TKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEA 4072
TKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEA
Sbjct: 3942 TKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEA 4001
Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW
Sbjct: 4002 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4061
Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTI 4192
EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTI
Sbjct: 4062 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTI 4121
Query: 4193 IEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVF 4252
IEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVF
Sbjct: 4122 IEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVF 4181
Query: 4253 LEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKE 4312
LEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKE
Sbjct: 4182 LEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKE 4241
Query: 4313 LVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK 4372
LVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK
Sbjct: 4242 LVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK 4301
Query: 4373 QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQS 4432
QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQS
Sbjct: 4302 QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQS 4361
Query: 4433 HVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQ 4492
HVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQ
Sbjct: 4362 HVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQ 4421
Query: 4493 VKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSH 4552
VKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSH
Sbjct: 4422 VKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSH 4481
Query: 4553 RLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQS 4612
RLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQS
Sbjct: 4482 RLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQS 4541
Query: 4613 PEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILA 4672
PEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILA
Sbjct: 4542 PEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILA 4601
Query: 4673 RKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDE 4732
RKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDE
Sbjct: 4602 RKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDE 4661
Query: 4733 LNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLER 4792
LNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLER
Sbjct: 4662 LNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLER 4721
Query: 4793 QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE 4852
QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE
Sbjct: 4722 QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE 4781
Query: 4853 KARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVY 4912
KARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVY
Sbjct: 4782 KARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVY 4841
Query: 4913 LDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSE 4972
LDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSE
Sbjct: 4842 LDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSE 4901
Query: 4973 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL 5032
LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL
Sbjct: 4902 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL 4961
Query: 5033 KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQ 5092
KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQ
Sbjct: 4962 KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQ 5021
Query: 5093 VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVV 5152
VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVV
Sbjct: 5022 VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVV 5081
Query: 5153 NSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDE 5212
NSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDE
Sbjct: 5082 NSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDE 5141
Query: 5213 WTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR 5272
WTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR
Sbjct: 5142 WTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR 5201
Query: 5273 QQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQI 5332
QQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQI
Sbjct: 5202 QQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQI 5261
Query: 5333 NSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTIL 5392
NSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTIL
Sbjct: 5262 NSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTIL 5321
Query: 5393 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5452
PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT
Sbjct: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5381
Query: 5453 DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI 5512
DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI
Sbjct: 5382 DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI 5441
Query: 5513 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL 5572
RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL
Sbjct: 5442 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL 5501
Query: 5573 LEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAK 5632
LEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAK
Sbjct: 5502 LEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAK 5561
Query: 5633 DMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLC 5692
DMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLC
Sbjct: 5562 DMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLC 5621
Query: 5693 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQ 5752
QSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQ
Sbjct: 5622 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQ 5681
Query: 5753 LIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5812
LIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA
Sbjct: 5682 LIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5741
Query: 5813 TMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSE 5872
TMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSE
Sbjct: 5742 TMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSE 5801
Query: 5873 ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS 5932
ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS
Sbjct: 5802 ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS 5861
Query: 5933 ATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 5992
ATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP
Sbjct: 5862 ATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 5921
Query: 5993 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 6052
GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE
Sbjct: 5922 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 5981
Query: 6053 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 6112
RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP
Sbjct: 5982 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 6041
Query: 6113 PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL 6172
PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL
Sbjct: 6042 PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL 6101
Query: 6173 KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQ 6232
KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQ
Sbjct: 6102 KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQ 6161
Query: 6233 QQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE 6292
QQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE
Sbjct: 6162 QQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE 6221
Query: 6293 DQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVT 6352
DQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVT
Sbjct: 6222 DQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVT 6281
Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET
Sbjct: 6282 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV
Sbjct: 6342 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6401
Query: 6473 NQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDG 6532
NQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDG
Sbjct: 6402 NQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDG 6461
Query: 6533 LKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYE 6592
LKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYE
Sbjct: 6462 LKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYE 6521
Query: 6593 RALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKII 6652
RALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKII
Sbjct: 6522 RALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKII 6581
Query: 6653 SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI 6712
SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI
Sbjct: 6582 SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI 6641
Query: 6713 PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQL 6772
PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQL
Sbjct: 6642 PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQL 6701
Query: 6773 GECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
GECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQEL
Sbjct: 6702 GECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6761
Query: 6833 EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLL 6892
EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLL
Sbjct: 6762 EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLL 6821
Query: 6893 TNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQK 6952
TNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQK
Sbjct: 6822 TNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQK 6881
Query: 6953 YKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTE 7012
YKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTE
Sbjct: 6882 YKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTE 6941
Query: 7013 KIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
KIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIK
Sbjct: 6942 KIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIK 7001
Query: 7073 AKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
AKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW
Sbjct: 7002 AKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7061
Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS
Sbjct: 7062 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7121
Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA
Sbjct: 7122 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7181
Query: 7253 STVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 7312
STVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ
Sbjct: 7182 STVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 7241
Query: 7313 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 7372
QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE
Sbjct: 7242 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 7301
Query: 7373 EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQN 7432
EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQN
Sbjct: 7302 EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQN 7361
Query: 7433 LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLE 7492
LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLE
Sbjct: 7362 LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLE 7421
Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7552
QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ
Sbjct: 7422 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7481
Query: 7553 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612
QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK
Sbjct: 7482 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7541
Query: 7613 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7672
VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL
Sbjct: 7542 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7601
Query: 7673 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLS 7732
KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLS
Sbjct: 7602 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLS 7661
Query: 7733 LLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKEL 7792
LLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKEL
Sbjct: 7662 LLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKEL 7721
Query: 7793 CEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA 7852
CEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA
Sbjct: 7722 CEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA 7781
Query: 7853 SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI 7912
SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI
Sbjct: 7782 SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI 7841
Query: 7913 VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 7972
VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA
Sbjct: 7842 VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 7901
Query: 7973 TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY 8032
TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY
Sbjct: 7902 TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY 7961
Query: 8033 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8092
TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL
Sbjct: 7962 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8021
Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAF 8152
QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAF
Sbjct: 8022 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAF 8081
Query: 8153 QQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR 8212
QQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR
Sbjct: 8082 QQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR 8141
Query: 8213 LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGR 8272
LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGR
Sbjct: 8142 LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGR 8201
Query: 8273 DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL-------- 8324
DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL
Sbjct: 8202 DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPES 8261
Query: 8325 ---------------SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 8369
SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS
Sbjct: 8262 PEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 8321
Query: 8370 YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQAL 8429
YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQAL
Sbjct: 8322 YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQAL 8381
Query: 8430 SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ 8489
SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ
Sbjct: 8382 SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ 8441
Query: 8490 KAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDAL 8549
KAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDAL
Sbjct: 8442 KAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDAL 8501
Query: 8550 MQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8609
MQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV
Sbjct: 8502 MQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8561
Query: 8610 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL
Sbjct: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8621
Query: 8670 SSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLS 8729
SSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLS
Sbjct: 8622 SSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLS 8681
Query: 8730 EPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLR 8789
EPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLR
Sbjct: 8682 EPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLR 8741
Query: 8790 YTNGPPPL 8797
YTNGPPPL
Sbjct: 8742 YTNGPPPL 8749
>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
[Homo sapiens]
Length = 3321
Score = 6481 bits (16814), Expect = 0.0
Identities = 3321/3321 (100%), Positives = 3321/3321 (100%)
Query: 5477 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 5536
MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML
Sbjct: 1 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
Query: 5537 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 5596
ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV
Sbjct: 61 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 120
Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT
Sbjct: 121 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180
Query: 5657 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 5716
SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ
Sbjct: 181 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 240
Query: 5717 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 5776
EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA
Sbjct: 241 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 300
Query: 5777 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 5836
QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL
Sbjct: 301 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 360
Query: 5837 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 5896
PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI
Sbjct: 361 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 420
Query: 5897 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 5956
AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR
Sbjct: 421 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 480
Query: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 6016
TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE
Sbjct: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 540
Query: 6017 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 6076
INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL
Sbjct: 541 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 600
Query: 6077 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 6136
EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK
Sbjct: 601 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 660
Query: 6137 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 6196
VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE
Sbjct: 661 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720
Query: 6197 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 6256
KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE
Sbjct: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 780
Query: 6257 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 6316
EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV
Sbjct: 781 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 840
Query: 6317 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 6376
LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS
Sbjct: 841 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 900
Query: 6377 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 6436
IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN
Sbjct: 901 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 960
Query: 6437 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 6496
KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL
Sbjct: 961 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020
Query: 6497 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 6556
FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS
Sbjct: 1021 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 1080
Query: 6557 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6616
MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII
Sbjct: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
Query: 6617 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 6676
VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR
Sbjct: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 1200
Query: 6677 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6736
AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK
Sbjct: 1201 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 1260
Query: 6737 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 6796
SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH
Sbjct: 1261 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 1320
Query: 6797 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6856
WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK
Sbjct: 1321 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 1380
Query: 6857 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 6916
SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI
Sbjct: 1381 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 1440
Query: 6917 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 6976
SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ
Sbjct: 1441 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 1500
Query: 6977 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 7036
ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT
Sbjct: 1501 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 1560
Query: 7037 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 7096
WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV
Sbjct: 1561 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620
Query: 7097 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 7156
SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF
Sbjct: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680
Query: 7157 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 7216
RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV
Sbjct: 1681 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 1740
Query: 7217 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 7276
NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD
Sbjct: 1741 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 1800
Query: 7277 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 7336
DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL
Sbjct: 1801 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 1860
Query: 7337 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 7396
EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL
Sbjct: 1861 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 1920
Query: 7397 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 7456
KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL
Sbjct: 1921 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 1980
Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII
Sbjct: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR
Sbjct: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD
Sbjct: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 7696
SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL
Sbjct: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 2220
Query: 7697 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 7756
SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL
Sbjct: 2221 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 2280
Query: 7757 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 7816
LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE
Sbjct: 2281 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 2340
Query: 7817 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 7876
KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR
Sbjct: 2341 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 2400
Query: 7877 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 7936
VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI
Sbjct: 2401 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 2460
Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE
Sbjct: 2461 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 2520
Query: 7997 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 8056
TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL
Sbjct: 2521 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
Query: 8057 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 8116
ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA
Sbjct: 2581 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 2640
Query: 8117 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 8176
RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK
Sbjct: 2641 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
Query: 8177 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 8236
SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS
Sbjct: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 2760
Query: 8237 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 8296
DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE
Sbjct: 2761 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 2820
Query: 8297 SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII 8356
SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII
Sbjct: 2821 SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII 2880
Query: 8357 RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 8416
RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG
Sbjct: 2881 RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 2940
Query: 8417 VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ 8476
VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ
Sbjct: 2941 VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ 3000
Query: 8477 TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 8536
TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS
Sbjct: 3001 TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 3060
Query: 8537 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8596
LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM
Sbjct: 3061 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 3120
Query: 8597 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 8656
QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL
Sbjct: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 3180
Query: 8657 EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH 8716
EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH
Sbjct: 3181 EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH 3240
Query: 8717 SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL 8776
SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL
Sbjct: 3241 SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL 3300
Query: 8777 SNNFARSFHPMLRYTNGPPPL 8797
SNNFARSFHPMLRYTNGPPPL
Sbjct: 3301 SNNFARSFHPMLRYTNGPPPL 3321
Score = 221 bits (562), Expect = 3e-56
Identities = 613/3378 (18%), Positives = 1294/3378 (38%), Gaps = 366/3378 (10%)
Query: 1170 IRNGVTKRGETLSWLKSRLKVLTEV------SSENEAQKQGDELAKLSSSFKALVTLLSE 1223
++ + + G+ L ++ LTE+ +EN K + L + L +L
Sbjct: 7 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 66
Query: 1224 VEKMLSNFGDCVQYKEIVKNSLEEL----------ISGSKEVQEQAEKILDTENLFEAQQ 1273
+EK + + I NS +L + SKE+ + E + + +
Sbjct: 67 IEK-----AKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
Query: 1274 LLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQER 1333
Q+ + + +++Q I Q L D ++++K E+ L L+ + E+
Sbjct: 122 CTEKMSQQVAELGRETEELRQMIKIRLQN---LQDAA-KDMKKFEAELKKLQAALEQA-- 175
Query: 1334 RIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIA 1393
Q TL E V R + SH + L S +ESL +
Sbjct: 176 --QATLTSPE--------VGRLSLKEQLSHRQHL-LSEMESLKPK--------------- 209
Query: 1394 VQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGS 1453
VQA L + A IP L A ++E+ +L+ T + M+ +++ +
Sbjct: 210 VQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 269
Query: 1454 NFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSF--- 1510
+ L I +E+ ++S I +++ I E I G +E+ S
Sbjct: 270 EMKHLQQLIEGAHREIEDKPVATS----NIQELQAQISRHEELAQKIKGYQEQIASLNSK 325
Query: 1511 -AQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTIL----GHLSQQQKFEENLRKIQ 1565
+ A + +T++ E L E + L+G +L H S +
Sbjct: 326 CKMLTMKAKHATMLLTVTEV----EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLL 381
Query: 1566 QSVSEFEDKLAVPIKICSS--------ATETYKVLQEHMDLCQALES----LSSAITAFS 1613
V+E + +I S T + + + QAL + +A S
Sbjct: 382 SPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPS 441
Query: 1614 ASARKVVNRDSCVQEAAA----LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLT 1669
SA + A A LQ+ +E + E+Q L L Q+ + L S T
Sbjct: 442 TSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIST 501
Query: 1670 WLERGEAKAS-------SPEMDISADRVKVEGEL-------QLIQALQNEVVS------- 1708
+E E K S SPE ++ + ++ L +L +L E+VS
Sbjct: 502 KMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADP 561
Query: 1709 --QASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAE 1766
Q + S L L E + ++ K K L E+L+++ + ++ LQ E
Sbjct: 562 AEQLALQSTLTVLAERMSTIRMKASGKRQLLE-EKLNDQLEE-----QRQEQALQRYRCE 615
Query: 1767 HQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGH 1826
+ D LLS + LS + MD + L ++ E+E K L L H
Sbjct: 616 ADELDSWLLSTKATLDTALSPPKEP-----MDMEAQLMDCQNMLVEIEQKVVALSELSVH 670
Query: 1827 LAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQ 1886
L LL+GKA +EA Q+ + + L E L L
Sbjct: 671 NENL----------LLEGKAHTK----DEAEQLAGKLRRLKGSLLE-------LQRALHD 709
Query: 1887 LRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT 1946
+ ++ T + K ESD+ DL A Q+ E A + + ++QR
Sbjct: 710 KQLNMQGT-AQEKEESDV---DLT-ATQSPGVQEWLAQA------------RTTWTQQRQ 752
Query: 1947 SCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQD-----QKEELLKSIEDIE-ER 2000
S +L E+ ++LL + S + + + A + +K ++L +E E+
Sbjct: 753 SSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK 812
Query: 2001 TDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREI 2060
+ E ++L Q +L + E E + ++ + ++
Sbjct: 813 SSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK 872
Query: 2061 NRLEVTWDDTKRLIHENQGQCCGL----IDLMREYQNLKSAVSKVLENASSVIVTRTTIK 2116
+ + D + E Q G I L ++ + SA S L++ + T +
Sbjct: 873 SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL 932
Query: 2117 DQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVD 2176
+E F++ AK+ K++ K K+L S+ + + +++ + +
Sbjct: 933 PEETETCLFNQEILAKDI-----KEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLG 987
Query: 2177 KW--LD--VSEKLEENMDRLRVSLSIWDDV----LSTRDE----IEGWSNNCVPQMAENI 2224
+ LD V+++ + +RL+ L+ +D+ S D ++ +N +AE I
Sbjct: 988 RLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI 1047
Query: 2225 SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQK 2284
+ +AE+ LKEF++ + R ++L + ++EL+K + +L I
Sbjct: 1048 EAIQ---QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSG 1104
Query: 2285 LEHAKEITEVAKGTLKDFT-AQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVK 2343
L + + L+D T EK D + ++ ++ E + L K K
Sbjct: 1105 LNQNLTLKSQYERALQDLADLLETGQEKMAGD---------QKIIVSSKEEIQQLLDKHK 1155
Query: 2344 DIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASL 2403
+ Q +S++ T+ +L RK S ++ + T L+ + AV + K L
Sbjct: 1156 EY---FQGLESHMILTE----TLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 1208
Query: 2404 QESLE--KHFSESMQEFQ------EWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDS 2455
+ LE H E QE E + + +E+ DR D L Q++ S
Sbjct: 1209 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL------YQHLKSS 1262
Query: 2456 VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCAS 2515
+++ Q KL V +G+ L +S S ++ Q+ + E + + + K+ L+
Sbjct: 1263 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 1319
Query: 2516 ELGSFEDQHRKLNLWIHEMEER--FNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2573
++ + L W+ ++R F T+ Q + ++ ++ F E+ A+ S
Sbjct: 1320 HWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEV-DAQSS 1378
Query: 2574 LDK--LSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLR---MTKEKLRSCQV-ALQEHE 2627
L LS QLL + S++ + +LL +EKL Q+ L
Sbjct: 1379 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 1438
Query: 2628 ALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK 2687
A+ E + + IQ ++++G K + + L + + + ++ ++ + +
Sbjct: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYK-AIHEYLQKYKGFKIDINCKQLTVDF-VNQ 1496
Query: 2688 GEQALRSSNKEGQRVIQT----QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKN 2743
+ S + E +R +T QL + + W + LE ++ W++Y
Sbjct: 1497 SVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQ 1556
Query: 2744 QLEQWMESVDQKI--EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHR----LIAKS 2797
L+ W E+ ++++ +H + Q ++ L+ ++ E + + LI
Sbjct: 1557 CLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNK 1616
Query: 2798 RELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLH 2857
+E + ++ Q + ++ K ++ V + H + D ++ + L
Sbjct: 1617 KEDVSSIVMSTLRELGQTW--ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSY---LM 1671
Query: 2858 SAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCE 2917
A+ L R+ ++G A Q ++ ++ L D E L + S+ ++ + E
Sbjct: 1672 EARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 1731
Query: 2918 LMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQ-LEQALEQFSALL 2976
+ ++ + W + + + + L+ Q+ +++S Q A ++Q ++ + LL
Sbjct: 1732 TLTNTLKEVNMRWNNLLEEIAEQLQSSKALL-QLWQRYKDYSKQCASTVQQQEDRTNELL 1790
Query: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
K + D+E+ ++L L + L +L E + D S
Sbjct: 1791 KAATNK------DIADDEVATWIQDCNDLLKGLGTVKDSLFFLH-ELGEQLKQQVDASAA 1843
Query: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQ-----QRFRKAFRDFQQWLVNAKITTAKCF 3091
S S + LC C+ + + + F K+ + W+V A+
Sbjct: 1844 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQG-- 1901
Query: 3092 DIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTL-----LTKEKAKGIQAK 3146
P + S++ST IQE + E + K + M + L+ L L ++ K +Q
Sbjct: 1902 QDPSHSSDLST----IQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQN- 1956
Query: 3147 VTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTE-KMVHESSNRLYD 3205
W S ++ S L++ +Q + F E ++L +TE K+ E S
Sbjct: 1957 ---LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQH 2013
Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE-GQAASKS-FRHRVSQLSSQYLA 3263
L ++R + Q+ E+ + L+ + Q+L E GQ + F +++ LS+Q+
Sbjct: 2014 LLEQQRAHELFQA---EMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQG 2070
Query: 3264 LSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHM----LDSYCHPTSDKSVLDSR 3319
+ +++ +D + + ++ ++L+ W+ + ++ L S P L
Sbjct: 2071 VIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDE 2130
Query: 3320 TLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3379
E + +Q I + V G+ +L + +Q +L +++ W S
Sbjct: 2131 VQFKEKVFLRQQGSYI---LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEE 2187
Query: 3380 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEV 3439
K +L L W + G+ + + + L++S H E M + K L V
Sbjct: 2188 QKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQM--RCKELENAV 2245
Query: 3440 LSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKE-----AVTKSEKLVRLH 3494
S++ L + + ++ Y++ ++ L ER +Q + +E ++ + + RL+
Sbjct: 2246 GSWTDDLTQLSLLKDTLSA-YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN 2304
Query: 3495 Q--EYQRDLKAFEVWLGQEQEKLDQYS------VLEGDAHTHETTLRDLQELQVHCAE-G 3545
+ + K WL Q + K+ Q ++E ++ + QE ++ + G
Sbjct: 2305 EWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMG 2364
Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3605
+ L + ++ I + + DR WQ ++ + + ++ +++
Sbjct: 2365 ERLAKASHESKASEIEYKLGKVNDR--------WQHLLDLIAARVKKLKETLVAVQQLDK 2416
Query: 3606 KFQQVDEWLKTAEEKVS-PRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQE 3664
+ WL E +++ P N + +L++ ++ ++ + V V +
Sbjct: 2417 NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
Query: 3665 ILDESHVNSRMG-CQATQ-----LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYS 3718
+L + + C + Q L R++ + +E+ +EE + ++ S +
Sbjct: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
Query: 3719 DWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL 3778
DW S+ + ++ V + ++LK E + + + + L+ ++ R +
Sbjct: 2537 DWLKSSERTAAFPSSS--GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAREN 2594
Query: 3779 EEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEI 3838
A L++ +H+ ++ L V L+ + +EF ++ W+ E
Sbjct: 2595 RTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD-- 2652
Query: 3839 LHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT---LKDK 3895
L + + +A++ + K+ QQ + + ++ + +GE L+E + + ++++
Sbjct: 2653 LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 2712
Query: 3896 IDQLQSDYQDLCS-IGKEHVFSLEAKVKDHE----DYNSELQEVEK-----WLLQMSGRL 3945
+D+L+ Q++ + + H + + D E D EL++ W + + L
Sbjct: 2713 LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 2772
Query: 3946 VAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQN 4005
++P SL ++ Q L ++ + A + L+ D + + + ++ +
Sbjct: 2773 LSPQPSSNLSL-SLAQPLRSERSGRDTPASVDSI--PLEWDHDYDLSRDLESAMSRALPS 2829
Query: 4006 VHAHLQGTKDSYSAICSTAQRMYQSLEHEL-QKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
Q KD Y + +LE ++ Q + D+ Q Q + ++ P+
Sbjct: 2830 EDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 2889
Query: 4065 PPLSR-------AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE-- 4115
S E + + L+ + + + L +L + +T A I + E
Sbjct: 2890 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT-AGVIDRWELL 2948
Query: 4116 --QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVS 4173
Q + ++L QNL Q W++ + +W +L D +++L+ ++R ++ + +
Sbjct: 2949 QAQALSKELRMKQNL-QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 3007
Query: 4174 QVKDFVKKLQSKQA---SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCL 4230
++K+ K + ++A S+N + + KE ++ +N +W +C
Sbjct: 3008 KLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRG 3067
Query: 4231 QREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNL----ARSDAESTAVHLEALKKLALALQ 4286
++ L + + +H+ + + + LE + + + DAE H + L ++ L
Sbjct: 3068 LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL 3127
Query: 4287 ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEEL 4346
E + + L+D +++ + D KE+ + R L+ +++ + LE+L
Sbjct: 3128 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL----KLLLKEVSRHIKELEKL 3183
Query: 4347 NVVQSRFQELMEWAEEQQ 4364
V S Q+L W+ +
Sbjct: 3184 LDVSSSQQDLSSWSSADE 3201
Score = 197 bits (500), Expect = 5e-49
Identities = 625/3331 (18%), Positives = 1275/3331 (38%), Gaps = 467/3331 (14%)
Query: 2006 LKEPTRQALQQRLRVFNQLEDELNSH----EHELCWLKDKAKQIAQKDVAF--------- 2052
L + T + + RL NQ L + E L W+ +KAK +A +A+
Sbjct: 31 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI-EKAKVLAHGTIAWNSASQLREQ 89
Query: 2053 ----------APEVDREINRLEVTWDDTKRLIHENQGQCCG-----LIDLMREYQNLKSA 2097
+ E+D E+ + T++L + C + +L RE + L+
Sbjct: 90 YILHQTLLEESKEIDSELEAM------TEKLQYLTSVYCTEKMSQQVAELGRETEELRQM 143
Query: 2098 VSKVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL 2156
+ L+N + + + L+ A + + + L S +HLLSE+
Sbjct: 144 IKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM 203
Query: 2157 KKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNC 2216
+ + K L + E + SL + L ++E +
Sbjct: 204 ESLKP------KVQAVQLCQSALRIPEDVV-------ASLPLCHAALRLQEEASRLQHTA 250
Query: 2217 VPQMAENISNLDNHLRAEEL-LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQ 2275
+ Q N ++A + +++E E+K+ +E H ++ D T N++
Sbjct: 251 IQQC--------NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ------ 296
Query: 2276 FIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNET 2335
+L ++ +E+ + KG + + +++ + K + + M E
Sbjct: 297 ----ELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT-------MKAKHATMLLTVTEV 345
Query: 2336 CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQL 2395
+ +D+ EL S S C S E G T +
Sbjct: 346 EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRS 405
Query: 2396 CS---KTQASLQESLEKHFSESMQEFQ--EWFLGAKAAAKESSDRTGDSKVLEAKLHDLQ 2450
S T AS+ + + + + S + Q + +A + G AKL DLQ
Sbjct: 406 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQ 465
Query: 2451 NILDSVSDGQSKLDAVTQEGQTLYAHLSKQ--IVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
+++ + ++++ +TLY L +Q S+Q TK E + L + + +
Sbjct: 466 RSWETLK------NVISEKQRTLYEALERQQKYQDSLQSISTKM-EAIELKLSESPEPGR 518
Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
+ + +E + D+ L I+E++ E + ES + P ++ + L E +
Sbjct: 519 SPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 578
Query: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQ-------NLLRMTKEKLRSCQV 2621
+ K S + QLL E+ + +E R Q L ++ + L TK L +
Sbjct: 579 STIRM--KASGKRQLLEEKLNDQLEEQRQ-EQALQRYRCEADELDSWLLSTKATLDTALS 635
Query: 2622 ALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKL 2681
+E +E L + I+ ++ LS + LL++G+ K
Sbjct: 636 PPKEPMDMEAQLMDCQNMLVEIEQKVVAL-----------SELSVHNENLLLEGKAHTKD 684
Query: 2682 NMAIGKGE-QALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVE 2740
G+ + L+ S E QR + + ++ + S V +T + +W
Sbjct: 685 EAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQA- 743
Query: 2741 RKNQLEQWMESVDQ--KIEHPLQPQPGL------KEKFVLLDHLQSILSEAEDHTRALHR 2792
R +Q S+ Q ++E L Q L + + +L+ H S AE A +
Sbjct: 744 RTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQH-----SAAETSGDAGEK 798
Query: 2793 LIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMY------- 2845
S+EL + E S +D + + ++ + T K ++ V E ++ ++Y
Sbjct: 799 PDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQK-LLQNVLEQEQEQVLYSRPNRLL 857
Query: 2846 --------------LDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSRE 2891
AV D L+ A EE+ S SG A ++ + ++L D
Sbjct: 858 SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSG--GAKRQSIHLEQKLYDGVS 912
Query: 2892 IGASRLSRVE-------SLAPE------VKQNTTASGCELMHTEMQALRADWKQW----- 2933
++ L VE +L PE Q A + M EM + + Q
Sbjct: 913 ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 972
Query: 2934 --EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQ---FSALLKTWAQQLT---- 2984
D + T C L+ +++L + + + Q+++ L+Q F LK L
Sbjct: 973 DNRDVIEDTLGC---LLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKY 1029
Query: 2985 --LLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
L + N E+ V E ++A+Q+AE ++ + + EL R L +
Sbjct: 1030 IILQKLANVFEQPV------AEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 1083
Query: 3043 LIK-----EYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFD-IPQN 3096
L K + + + + + N+ L+ ++ +A +D L + A I +
Sbjct: 1084 LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSS 1143
Query: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKN 3156
E+ L K +E+ E+ + K ++S + KE + + A K
Sbjct: 1144 KEEIQQLLDKHKEYFQGLESHMILTETLFRK--IISFAVQKETQFHTEL-MAQASAVLKR 1200
Query: 3157 FHSNLHQKESALE---NLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQ 3213
H + E LE +L ++ E ++ + +V E+ +RL D +
Sbjct: 1201 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV-GLVEENEDRLID---RITLY 1256
Query: 3214 QKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVS 3273
Q L+S L E Y+P+L ++ + ++L + S +++QL +L+ +N +++
Sbjct: 1257 QHLKSSLNE---YQPKLYQVLDDGKRLLISISCS-DLESQLNQLGECWLSNTNKMSKELH 1312
Query: 3274 RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLK-----LEALLS 3328
RL+ I+ ++ +L W+ A L+ + + +SV + L+ L A L
Sbjct: 1313 RLETILKHWTRYQSESADLIHWLQSAKDRLEFW----TQQSVTVPQELEMVRDHLNAFLE 1368
Query: 3329 VKQEKEIQMKM---IVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3385
+E + Q + +++ G +L+ + T++ +L + W LL+ + +L
Sbjct: 1369 FSKEVDAQSSLKSSVLSTGNQLLRLKKVD-TATLRSELSRIDSQWTDLLTNIPAVQEKLH 1427
Query: 3386 GALSKWTSYQDGVRQFSGWMDSMEANLNESERQ----------HAELR-------DKTTM 3428
+ + + W+ ME + + E H L+ D
Sbjct: 1428 QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 1487
Query: 3429 LGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSE 3488
+N+ VL SS + +E K + T+ +L + + ++ +Q E + E
Sbjct: 1488 QLTVDFVNQSVLQISS--QDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKIQLLE 1542
Query: 3489 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ--VHCAE-- 3544
L+ EY+ +++ + W ++++L Q + GD + + L+D Q+L+ + E
Sbjct: 1543 GLLESWSEYENNVQCLKTWFETQEKRLKQQHRI-GDQASVQNALKDCQDLEDLIKAKEKE 1601
Query: 3545 ----GQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL 3600
Q L + + +EDV S I + L L Q W H + + + +V+++
Sbjct: 1602 VEKIEQNGLALIQNKKEDV--SSIVMS---TLRELGQTWANLDHMVGQLKILLKSVLDQW 1656
Query: 3601 RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA 3660
+ F +++ +L A +S + ++Q+ ++ +++ +++ G+
Sbjct: 1657 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 1716
Query: 3661 RAQEILDESH--VNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEE----SESSL 3714
++L E H V + ++ R+ LL ++ EQ++ + +Q + S+
Sbjct: 1717 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 1776
Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
S+ T++ K AT D D + ++ LLK + L E GE+
Sbjct: 1777 STVQQQEDRTNELLK-AATNKDIADD-EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQL 1834
Query: 3775 VKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAE 3834
+ ++ A ++ + + L L + K+ +L+ G+ + F+ +AL WI E
Sbjct: 1835 KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVE 1894
Query: 3835 YQEILHVPE----------EPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALL 3884
+EIL + + +ME E K Q+ K+ S+ P + + E G L
Sbjct: 1895 AEEILQGQDPSHSSDLSTIQERME--ELKGQMLKFSSM-------APDLDRLNELGYRL- 1944
Query: 3885 ELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
+ D +K ++ L + + S E L++ + H+ + + + ++L+Q +
Sbjct: 1945 -PLNDKEIK-RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQK 2002
Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI--GQCADHLQAKL 4002
L + + + + +Q H+ E+ + L+++ + G L+ GQ D + L
Sbjct: 2003 LAVE---ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL 2059
Query: 4003 KQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ--PDLE 4060
K L + + + AQ+ ++ ++++ ++ ++ + WL V P
Sbjct: 2060 K------LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSG 2113
Query: 4061 PSPQP-PLSRAEAIKQVKHFRA---LQEQARTYL------DLLCSMCDLSNASVKTTAKD 4110
P PL +A + F+ L++Q L LL S + A+++ +
Sbjct: 2114 LGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAE 2173
Query: 4111 IQQTEQTIEQKLVQAQN----LTQGW-----------EEIKHLKSELWIYLQDADQQLQN 4155
IQ+ ++ +L + + L + W E+++ K +L L D ++L
Sbjct: 2174 IQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHA 2233
Query: 4156 MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4215
+ R ELE N V D + +L + +++ I + + S ++ + L
Sbjct: 2234 EQMRCKELE-----NAVGSWTDDLTQLSLLKDTLSAYI------SADDISILNERVELLQ 2282
Query: 4216 DQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLE--KFTTEWDNLARSDAESTAV 4273
QW +LC Q L L+R++ +R +N VF E K EW S
Sbjct: 2283 RQWEELCHQ---LSLRRQQIGER-------LNEWAVFSEKNKELCEWLTQMESKVSQNGD 2332
Query: 4274 HL--EALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKEL----VKEQTSHLEQRWFQ 4327
L E ++KL QE ++ K Q Q+M E L E ++ + + RW
Sbjct: 2333 ILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQH 2392
Query: 4328 LEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL-KQSPPPDMAQNLLMD 4386
L DLI +++ L + + L W + +A+ + S + Q L +
Sbjct: 2393 LLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNE 2452
Query: 4387 HLAICSELEAKQM-------LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSD 4439
+ ++E L + L+ D D D E IQ+A + +
Sbjct: 2453 QQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA---ECDSIQQATRNLDRRWRNICA 2509
Query: 4440 LVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSA 4499
+ +RR + + +FL + ++ ER F ++ +++K ++
Sbjct: 2510 MSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAF 2569
Query: 4500 QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEK 4559
Q + ++ + Q R L +E + + E +D++ ++ + L+ L+
Sbjct: 2570 QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKH 2629
Query: 4560 NLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY---E 4616
+ R+ F+ D WL + D+ ++ + SE Q AK + + E
Sbjct: 2630 FIGQREEFETARDSILVWLTEMDL----QLTNIEHFSECDVQ-AKIKQLKAFQQEISLNH 2684
Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK------------DKFY 4664
N + + G+ ++ +D + + E+L+ L R + + D +
Sbjct: 2685 NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH 2744
Query: 4665 KVQEAILARKEYASLIEL--------------TTQSLSELEAQFLRMSKVPTDL-AVEEA 4709
+ + L ++ A+L +L + +LS AQ LR + D A ++
Sbjct: 2745 DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 2804
Query: 4710 LSLQ-----DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKR 4764
+ L+ D R + ++ + DE Q + F G L + +L +
Sbjct: 2805 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGK 2864
Query: 4765 -------QTEQRVSLLEDTT-------SAYQEHEKMCQQLERQLKSVKEEQSKVNEETLP 4810
Q +Q +++ T ++Y+ + K+ + + SVK + K+ EE
Sbjct: 2865 ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEE--- 2921
Query: 4811 AEEKLKMYHSL-AGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLT 4869
EE L + +L + Q +G++ + + + L+ L + + +Q WQ
Sbjct: 2922 -EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL------RMKQNLQKWQ------- 2967
Query: 4870 SAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL--NLQDIQEEIRKI 4927
F ++++ WL + EL L+L ++Q I+ +I+K+
Sbjct: 2968 ------------------QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 3009
Query: 4928 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQAT 4987
+ Q+ V I+ +++ E FT+A S DL+ L++++ + L +
Sbjct: 3010 KELQKAVDHRKAIILSINLCSPE-FTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL 3068
Query: 4988 LTEIYSQCQRYYQVFQAANDWLED----AQELLQLAGNGLDVESAEENLKSHMEFFSTED 5043
L + QCQ ++++ LE+ E++ + N LD E +++ K M+
Sbjct: 3069 LQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSN-LDAEILQDHHKQLMQIKHELL 3127
Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLEQK 5074
+ + L + L L+ G + LE K
Sbjct: 3128 ESQLRVASLQDMSCQL--LVNAEGTDCLEAK 3156
Score = 171 bits (434), Expect = 2e-41
Identities = 594/3328 (17%), Positives = 1269/3328 (38%), Gaps = 427/3328 (12%)
Query: 4187 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4246
A+V +E+ +L K P K+I L + RQ+ N + + +Y++ +
Sbjct: 5 AAVQKFLEQNGQLGK----PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
Query: 4247 NVVEVFLEKF------TTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ 4300
++ ++EK T W N A E +H L+E K +L+ +
Sbjct: 61 ELILKWIEKAKVLAHGTIAW-NSASQLREQYILH-------QTLLEESKEIDSELEAMTE 112
Query: 4301 KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWA 4360
K+ ++ E + +Q + L + +L +IK ++Q +++ ++ ++L
Sbjct: 113 KLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAAL 172
Query: 4361 EEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNER 4420
E+ Q + P++ + L + L+ L ++ LK ++ + L + E
Sbjct: 173 EQAQATLTS-------PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPED 225
Query: 4421 QVIQKALSDA----QSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI 4476
V L A Q + L Q+ + A+ + Q+ + I+ R+I
Sbjct: 226 VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI 285
Query: 4477 MFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL---------WAQGRELMKEVTEQ 4527
+ ++ Q+ + +K YQ ++ L A+ ++ VTE
Sbjct: 286 EDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 345
Query: 4528 E-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD 4582
E ++ G+L S + SV+ + R L + +E ++ + +
Sbjct: 346 EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT-----EESGEEGTNSEISSP 400
Query: 4583 IVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY-- 4640
+ N + ++ +A YQ + + LQ I PS + Y
Sbjct: 401 PACRSPSPVANTDASVNQDIAYYQALSAE---------RLQTDAAKIHPSTSASQEFYEP 451
Query: 4641 -----LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS-ELEAQF 4694
+ KL L R + + + +K + EA+ +++Y + QS+S ++EA
Sbjct: 452 GLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD----SLQSISTKMEAIE 507
Query: 4695 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQK-KEGFRSTGQPWQPDKML 4753
L++S+ P E+ + +A++DE+ L + ++EL E S P + L
Sbjct: 508 LKLSESPEPGRSPESQMAEH--QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 565
Query: 4754 HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEE 4813
L + L +R+S + S + Q LE +L EEQ + E+
Sbjct: 566 ALQSTLTVL----AERMSTIRMKASGKR------QLLEEKLNDQLEEQRQ--------EQ 607
Query: 4814 KLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIG 4873
L+ Y A L DS ++ + T+ L+P +P+ E Q+ E++ A+
Sbjct: 608 ALQRYRCEADEL-DSWLLSTKATLDTA-LSPPKEPMDMEAQLMDCQNMLVEIEQKVVALS 665
Query: 4874 ETVTECESRMVQ-SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQE 4932
E E+ +++ + E + LRR+K L L+L +++ QE
Sbjct: 666 ELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSL-----LELQRALHDKQLNMQGTAQE 720
Query: 4933 EVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIY 4992
+ +S + + S +E +A+ + + SL + EL+ ++ E +++ L +
Sbjct: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE----QKSLLRSVA 776
Query: 4993 SQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEEL 5052
S+ + AA E AG DV S E ++ E S EDQ E L
Sbjct: 777 SRGEEILIQHSAA--------ETSGDAGEKPDVLSQELGMEG--EKSSAEDQMRMKWESL 826
Query: 5053 HSLVATLDPLIKPTGKEDLEQKVASLELR---------SQRMSRDSGAQVDLLQRCTAQW 5103
H +T L++ +++ EQ + S R ++D A LL +
Sbjct: 827 HQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAF 886
Query: 5104 HDYQK----AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNS---FH 5156
+ A+ + I L E+KL + ++ + EE+L AL+ F+
Sbjct: 887 EEVSSQSGGAKRQSIHL----EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFN 942
Query: 5157 EKIVA--LEEKASQLEKTGNDASKA---------TLSRSMTTVWQRWTRLRAVAQDQEKI 5205
++I+A ++E + +++K N S+A + ++ + R + L +V +
Sbjct: 943 QEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQ 1002
Query: 5206 LEDAVDEWTGFNNKVKKA-TEMIDQ----LQDKLPGSSAEKASKAELLTL----LEYHDT 5256
+++ + + F N +K T + D LQ A + E + L+ D
Sbjct: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062
Query: 5257 FVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5316
++EL+++ L + E P MQE++ +QD + + +
Sbjct: 1063 GIIELKRRGDKLQV-------------------EQPSMQELSKLQDMYDELMMIIGSRRS 1103
Query: 5317 LVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK 5376
+ Q L + E + + ++ +E + I + EE+Q LL + + Q +E
Sbjct: 1104 GLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES 1163
Query: 5377 ---MAEEQKEKYLGL----YTILPSELSLQLAEVALDLKIRDQIQDKIKEV-EQSKATSQ 5428
+ E K + T +EL Q + V R + I E Q
Sbjct: 1164 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ 1223
Query: 5429 ELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLME-LDAAVQKFL 5487
ELSRQ++ + + ++ ++ D ++ T + L L+ KL + LD + +
Sbjct: 1224 ELSRQLEVVESSIPSV-GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
Query: 5488 EQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK 5547
+ L ++ +L E + L +L H Y ++ W++ AK
Sbjct: 1283 SIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAK 1339
Query: 5548 -VLAHGTIAWNSASQLREQYILH-QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ 5605
L T + Q E H LE SKE+D++ + L + +K+
Sbjct: 1340 DRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV--D 1397
Query: 5606 VAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPE----VG 5661
A L E + L N+ + + + + + + A+ + + ++ E
Sbjct: 1398 TATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKD 1457
Query: 5662 RLSLKEQLSHR--QHLLSEMESLKPKVQAVQLC-----QSALRIPEDVVAS-----LPLC 5709
++K + ++ L + + K + QL QS L+I V S
Sbjct: 1458 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 1517
Query: 5710 HAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS 5769
+ + LQ ++ +++ + + +YE ++ L+ E + ++ +
Sbjct: 1518 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH-RIG 1576
Query: 5770 NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE 5829
+ +Q + ++L IK ++++ + L K + ++ + L +
Sbjct: 1577 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 1636
Query: 5830 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE-SGEEGTNSEISS--PPACRSPSPVA 5886
+LD G+ LL V ++ S + +I+S A S S
Sbjct: 1637 NLD---------------HMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR 1681
Query: 5887 NTDASVNQDIAYYQALSAERLQTDAAKIHPS-------TSASQEFYEPGLEPSATAKLGD 5939
S+ + Q + + LQ D K S T+ + P + + T L +
Sbjct: 1682 LLTGSL--EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKE 1739
Query: 5940 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
+ W L I+E+ ++ L+ Q+Y+D + ++ ++ E + +E + + +
Sbjct: 1740 VNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIA 1799
Query: 6000 MAEHQALMDEILMLQDEINELQSSL--AEELVSE-SCEADPAEQLALQSTLTVLAERMST 6056
E + + L + ++ SL EL + + D + A+QS L++ +
Sbjct: 1800 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859
Query: 6057 IRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP 6116
+ ++ L+ + D + +AL+ + EA+E+ L + + LS +E
Sbjct: 1860 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEI---LQGQDPSHSSDLSTIQER 1916
Query: 6117 M-DMEAQLMDCQNMLVEIEQKVVALSELSVHNENL--LLEGKAHTKDEAEQLAGKLRRLK 6173
M +++ Q++ +M ++++ L ++++ + + H + Q + +L+
Sbjct: 1917 MEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 1976
Query: 6174 GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ 6233
LL+ Q L + M+ Q +++ V++ S Q L Q R
Sbjct: 1977 SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI----SGNYQHLLEQQRA------------ 2020
Query: 6234 QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED 6293
+ + E+ ++ +L S+ G+ L++ + + K +LS +
Sbjct: 2021 HELFQAEMFSRQQILHSIIIDGQR-LLEQGQVDDRDEFNLKLTLLSNQ------------ 2067
Query: 6294 QMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRL----LSGVPLY-KGDVPTQDK 6348
W+ + + ++ ++ + + Q Q + R +S +P+ G VP +
Sbjct: 2068 -----WQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ 2122
Query: 6349 SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY-----DGVSATSTWLDDVEERLFV 6403
A T L D + Q E+V + G+ ++ ++L +A L +++E+
Sbjct: 2123 QART-LFDEV-QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKS 2180
Query: 6404 ATALLPEETETCLF---NQEILAKDIKEMSEEMDKNKNLFSQAFPENGD----------- 6449
A+ L E+ + F + E K I + E++ K SQ+ P++ +
Sbjct: 2181 ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE 2240
Query: 6450 -------------NRDVIEDTLGCLLG---------RLSLLDSVVNQRCHQMKERLQQIL 6487
+++DTL + R+ LL + CHQ+ R QQI
Sbjct: 2241 LENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 2300
Query: 6488 NFQND--------------LKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 6533
N+ L + + ++ N I+++++ ++ E+I Q+ + L
Sbjct: 2301 ERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQL 2360
Query: 6534 KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER 6593
++ + + ++E +L K+ D + L+ +I +R L + L Q ++
Sbjct: 2361 QQMGERLAKASHESKASEIE----YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK 2416
Query: 6594 ALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH-------MILTET 6646
+ L L + ++A + EEIQ+ L++ +E + +E H + L E
Sbjct: 2417 NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
Query: 6647 LFRKIISFAVQKE----TQFHTELMAQASAVLKRAHKRGVELEYILETW-SHLD-----E 6696
L + A E Q L + + + +R +++E W LD E
Sbjct: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
Query: 6697 DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL 6756
D + S + SS + V + E + + H + E K Y+ L R
Sbjct: 2537 DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENR- 2595
Query: 6757 LISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKD 6816
+ S L+ +++ + W + +++ L RL+ + +++ ++ WL
Sbjct: 2596 --TDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 2653
Query: 6817 RLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL-RLKKVDTA 6875
+L ++ E + V+ + F +E+ + +++ G QL+ + + +D A
Sbjct: 2654 QL-----TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA 2707
Query: 6876 TLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMD-----------KLPSRHAISEVMSWIS 6924
+ EL + ++ + +KL +L + +L A+S+ + W
Sbjct: 2708 IIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSD-LHWHD 2766
Query: 6925 LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 6984
+ + + + +++ + G + + +++ + L S+D+ES
Sbjct: 2767 RSADSLLSPQPS--SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL---SRDLES 2821
Query: 6985 KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 7044
S ++ G +K + L+G V GL S E+ ++ L + +
Sbjct: 2822 AMSRALPSEDEEGQDDKDF-YLRGAV--------GLSGDHSALESQIRQLGKALDDSRFQ 2872
Query: 7045 LKQQHRI------------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--GLALIQ 7090
++Q I L +C D +K E ++++ E++ G +
Sbjct: 2873 IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLH 2932
Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
+ + + ++ W L ++ +K L +W + I ++L +
Sbjct: 2933 STETQTAGVI--------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
Query: 7151 YSLSRFRL--LTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
L + + L+ ++ +++Q+ L+ LQ ++ ++ + ++ + + +
Sbjct: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRD 3043
Query: 7209 LTNTLKEVNMRWN---NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7265
L + L ++N RW+ +LLEE LQ AL+Q Q + + S ++ + R NE+
Sbjct: 3044 LQDRLSQMNGRWDRVCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDRRKNEI 3100
Query: 7266 LKAATNKD--IADDEVATWIQDCNDLLK 7291
+ +N D I D +Q ++LL+
Sbjct: 3101 VPIDSNLDAEILQDHHKQLMQIKHELLE 3128
Score = 155 bits (391), Expect = 2e-36
Identities = 476/2589 (18%), Positives = 980/2589 (37%), Gaps = 324/2589 (12%)
Query: 2960 GQVAQL-EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3018
G++ +L +Q + Q L Q + LE N E++ W + ++L A
Sbjct: 26 GKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ 85
Query: 3019 LKSQ-------LNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRK 3071
L+ Q L E +L + K+ L Y C K + Q+ +
Sbjct: 86 LREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY----------CTEK---MSQQVAE 132
Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES-------ENGQHKLNMM 3124
R+ ++ KI D +++ + L+K+Q L ++ E G+ L
Sbjct: 133 LGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQ 192
Query: 3125 LS-KGELLSTLLT-KEKAKGIQAKVTAAK--ED----WKNFHSNLHQKESA--LENLKIQ 3174
LS + LLS + + K K + +Q +A + ED H+ L +E A L++ IQ
Sbjct: 193 LSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQ 252
Query: 3175 ----MKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQL 3230
M+ V E + + ++++ + + D P Q+LQ+ Q+
Sbjct: 253 QCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA----------QI 302
Query: 3231 NRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIK 3290
+R +E AQ++ K ++ +++ L+S+ L+ K L V E + G +
Sbjct: 303 SRHEELAQKI-------KGYQEQIASLNSKCKMLTMKAKHATMLLT--VTEVEGLAEGTE 353
Query: 3291 ELQDWM--TDAIH-----MLDSYCH----PTSDKSVLDSRTLKLEAL------------- 3326
+L + T + H M CH P +++S + ++ +
Sbjct: 354 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTD 413
Query: 3327 LSVKQE----KEIQMKMIVTRGESVLQNTS-------PEGIPTIQQQLQSVKDMWASLLS 3375
SV Q+ + + + + T + +TS P P+ +L ++ W +L +
Sbjct: 414 ASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKN 473
Query: 3376 AGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQ----HAELRDKTTMLGK 3431
+ L AL + YQD ++ S M+++E L+ES +++ + ++ +
Sbjct: 474 VISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDE 533
Query: 3432 AKLLNEEVLSY-SSLLETI--EVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSE 3488
+L +E+ SSL E + E A E Q L L ER I+ +A E
Sbjct: 534 ILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE 593
Query: 3489 KLVRLHQEYQRDLKAFE----------VWLGQEQEKLDQYSVLEGDAHTHETTLRDLQEL 3538
+ + E QR +A + WL + LD + E L D Q +
Sbjct: 594 EKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNM 653
Query: 3539 QVHCAEGQALLNSVLHTREDVIPSGIPQAEDRA------LESLRQDWQAYQHRLSETRTQ 3592
V + L+ + E+++ G +D A L L+ Q L + +
Sbjct: 654 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLN 713
Query: 3593 FNNVVNK-----LRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEE 3647
+ + L + V EWL A+ + + +RQS+ L Q K+ +E
Sbjct: 714 MQGTAQEKEESDVDLTATQSPGVQEWL--AQARTTWTQQRQSS-------LQQQKELEQE 764
Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3707
+ + + V +R +EIL + G E+ L +E+
Sbjct: 765 LAEQKSLLRSVASRGEEILIQHSAAETSGDAG---------------EKPDVLSQELGME 809
Query: 3708 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKS- 3766
E S+ + S H+ F +TK + V+ ++ + L + G L K
Sbjct: 810 GEKSSAEDQMRMKWESLHQEF---STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGD 866
Query: 3767 AREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCK 3826
+ + AV L +G ++ E++ + +++ +HL ++ D
Sbjct: 867 VPTQDKSAVTSLLDG--------LNQAFEEVSSQSGGAKRQ------SIHLEQKLYDGVS 912
Query: 3827 ALTQWIAEYQEILHV-----PEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGE 3881
A + W+ + +E L V PEE + L+ ++ K + + + ++ +
Sbjct: 913 ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 972
Query: 3882 ALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLL 3939
++++D L ++ L S C KE + + D + + L + + +L
Sbjct: 973 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 1032
Query: 3940 QMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ 3999
Q + + E +E I Q + + F+ + L+ +GD L
Sbjct: 1033 QKLANVFEQPVAE--QIEAIQQA-------EDGLKEFDAGIIELKRRGDKL--------- 1074
Query: 4000 AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL 4059
+++Q L +D Y + L L + LQ L Q +
Sbjct: 1075 -QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKM 1133
Query: 4060 EPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE 4119
+ +S E I+Q+ L + + L M K + +Q+ Q
Sbjct: 1134 AGDQKIIVSSKEEIQQL-----LDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHT 1188
Query: 4120 QKLVQAQNLTQGWE----EIKHLKSELWIYLQDADQQLQNMKR--RHSELELNIAQNMVS 4173
+ + QA + + E++++ E W +L + Q+L S + + +
Sbjct: 1189 ELMAQASAVLKRAHKRGVELEYIL-ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENED 1247
Query: 4174 QVKDFVKKLQSKQASVNTIIEKVNKLTKKEE--------SPEHKEINHLNDQWLDLCRQS 4225
++ D + Q ++S+N K+ ++ + S ++N L + WL +
Sbjct: 1248 RLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKM 1307
Query: 4226 NNLCLQREEDLQRTRDYH----DCMNVVEVFLEK--FTTEWDNLARSDAESTAVHLEALK 4279
+ + E L+ Y D ++ ++ ++ F T+ + E HL A
Sbjct: 1308 SKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFL 1367
Query: 4280 KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVS 4339
+ + + + + +++ +D L + + S ++ +W L I +Q
Sbjct: 1368 EFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL-RSELSRIDSQWTDLLTNIPA-VQEK 1425
Query: 4340 VTNLEELNVVQSR--FQELMEWAEEQQPNIA---EALKQSPPPDMAQNLLMDHLAICSEL 4394
+ L+ ++ + SR E+M W + I + +K S L + ++
Sbjct: 1426 LHQLQ-MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 1484
Query: 4395 EAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSE 4454
KQ+ + + + ++ + Q ++ SD L + + + L ++E
Sbjct: 1485 NCKQLTVDFVNQSVLQISS-------QDVESKRSDKTDFAEQLGAM-NKSWQILQGLVTE 1536
Query: 4455 KTQFLMAVFQATSQIQQH----------ERKIMFREHICLLPDDVSKQVKTCKSAQASLK 4504
K Q L + ++ S+ + + + K + ++H V +K C+ + +K
Sbjct: 1537 KIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIK 1596
Query: 4505 TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4564
+ EV + G L++ E S V+ L+EL + + L +L+ L K+++ +
Sbjct: 1597 AKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN-LDHMVGQLKILLKSVLDQ 1655
Query: 4565 -KHFKEDFDKACHWLKQADIVTFPEINLMNESSE-LHTQLAKYQNILEQSPEYENLLLTL 4622
K FDK +L +A + L+ S E + Q+ QN+ + + E L
Sbjct: 1656 WSSHKVAFDKINSYLMEARY-SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKF 1714
Query: 4623 QRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIEL 4682
+L + L+ L + ++N ++ ++ + + + Y +
Sbjct: 1715 GSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQ 1774
Query: 4683 TTQSLSELEAQFLRMSKVPT--DLAVEEALSLQDGCRAILDEVAGLGEAVDEL------- 4733
++ + E + + K T D+A +E + C +L GLG D L
Sbjct: 1775 CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLK---GLGTVKDSLFFLHELG 1831
Query: 4734 -NQKKEGFRSTGQPWQPDKML---HLVTLYHRL-KRQTEQRVSLLEDTTSAYQEHEKMCQ 4788
K++ S Q D++ HL L L K+QT + +L+ Y+ K +
Sbjct: 1832 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD-----YETFAKSLE 1886
Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDP 4848
LE + EE L ++ + S ++Q+ LK + +AP LD
Sbjct: 1887 ALEAWIVEA--------EEILQGQDP--SHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 1936
Query: 4849 L--------AYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWL 4900
L +K ++Q+ L++S E ++ +S ++Q F + +++L
Sbjct: 1937 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFL 1996
Query: 4901 RRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELIS 4960
+ + +L+ V + N Q + E+ R ++ Q E+ S +I++++ + + +
Sbjct: 1997 VQTEQKLA--VEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDR 2054
Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG 5020
+ L LS + + R+ + Q QRY ++ + WL + L ++G
Sbjct: 2055 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS-YLPMSG 2113
Query: 5021 NGLDVESAEENLKSHMEFFSTEDQFHSN--LEELHSLVATLDP-----LIKPTGKED-LE 5072
G S L+ F E QF L + S + T++ L +G E L+
Sbjct: 2114 LG----SVPIPLQQARTLFD-EVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQ 2168
Query: 5073 QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKT 5132
++A ++ + + S Q L W +K + +E + +KKLS+ SL
Sbjct: 2169 AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQ-SLPDH 2227
Query: 5133 SSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRW 5192
AE+ K L + V S+ + + L L + + L+ + + ++W
Sbjct: 2228 HEELHAEQMRC--KELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQW 2285
Query: 5193 TRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLE 5252
L + + + + ++EW F+ K K+ E + Q++ K+ + ++L
Sbjct: 2286 EELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV-------SQNGDILI--- 2335
Query: 5253 YHDTFVLELEQQ-QSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEIT----AMQDRCLNM 5307
+ + +L++ Q + + ++ + + Q G EI + DR ++
Sbjct: 2336 --EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHL 2393
Query: 5308 QEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEA 5367
+ + K +K+ L + ++ ++S++ W+ + L P + EE+Q L E
Sbjct: 2394 LDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQ 2453
Query: 5368 TNHRQNIEK 5376
+++IEK
Sbjct: 2454 QELQRDIEK 2462
Score = 132 bits (333), Expect = 1e-29
Identities = 621/3292 (18%), Positives = 1212/3292 (36%), Gaps = 545/3292 (16%)
Query: 3679 ATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
A+QL +Y L +LE+ K ++ E++++ E L+S T K + VA +
Sbjct: 83 ASQLREQY-ILHQTLLEESKEIDSELEAMTEKLQYLTSVY----CTEKMSQQVAELGRET 137
Query: 3739 DTV--MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERL--------RK 3788
+ + M+ +L+ L+ KDM+K + LK + E+A L E RL R+
Sbjct: 138 EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQ 197
Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE-------------KGLHLAKEFS-------DKCKAL 3828
+ ME LK V+ L L L +E S +C +
Sbjct: 198 HLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIM 257
Query: 3829 TQWIAEY----QEILHVPE---------EPK----MELYEKKAQLSKYKSLQQTVLSHEP 3871
+ +Y QE+ H+ + E K + E +AQ+S+++ L Q + ++
Sbjct: 258 QAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQE 317
Query: 3872 SVKSVREKGEALLELVQDVTLK---DKIDQLQSDYQDL----------------CSIGKE 3912
+ S+ K + L + T+ +++ L +DL + G+
Sbjct: 318 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRC 377
Query: 3913 H-VFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME 3971
H + S + E NSE+ + R +P +S + Q +A+++A+
Sbjct: 378 HTLLSPVTEESGEEGTNSEISSPP------ACRSPSPVANTDAS---VNQDIAYYQALSA 428
Query: 3972 EIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSL 4031
E RL K + + L+ + A L + S+ + + ++L
Sbjct: 429 E------RLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTL 482
Query: 4032 EHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE------- 4084
L++ QD+LQ + A++ L SP+P R+ + +H + E
Sbjct: 483 YEALERQQKYQDSLQSISTKMEAIELKLSESPEP--GRSPESQMAEHQALMDEILMLQDE 540
Query: 4085 ----QARTYLDLLCSMCDLSNAS--------------VKTTAKDIQQTEQTIEQKL---V 4123
Q+ +L+ C+ A + T Q +E+KL +
Sbjct: 541 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 600
Query: 4124 QAQNLTQGWEEIKHLKSEL--WIYLQDA--DQQLQNMKR-RHSELELNIAQNMVSQVKDF 4178
+ Q Q + + EL W+ A D L K E +L QNM+ +++
Sbjct: 601 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 660
Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
V L ++ + TK E ++ L L+L R ++ L + Q
Sbjct: 661 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720
Query: 4239 TRDYHDCMNV-----VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIE 4293
+ + V+ +L + T W +S L+ K+L L E+K +
Sbjct: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS-------LQQQKELEQELAEQKSLLR 773
Query: 4294 DLKDQKQK-MIEHL------NLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEEL 4346
+ + ++ +I+H + +K V Q +E ED ++ K + + +E
Sbjct: 774 SVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE---SLHQEF 830
Query: 4347 NVVQSRFQELMEWAEEQ----QPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLK 4402
+ Q Q ++E +EQ +PN L P D A+ S LL
Sbjct: 831 STKQKLLQNVLEQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTS-------LLD 880
Query: 4403 SLIKDADRVMADLGLNERQVI--QKALSDAQSHVNCLSDLVGQRRKYLNKALSEKT---- 4456
L + + V + G +RQ I ++ L D S + D V +R L E+T
Sbjct: 881 GLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCL 940
Query: 4457 --QFLMAVFQATSQIQQHERKIMFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTG 4512
Q ++A + + K +F + D DV + C + SL + V
Sbjct: 941 FNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSL--LDSVVNQ 998
Query: 4513 LWAQGRELMKEVTE-QEKSEVLGK---------LQELQSVYDSVLQKCSHRLQELEKNLV 4562
Q +E ++++ Q +VL LQ+L +V++ + + +Q+ E L
Sbjct: 999 RCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL- 1057
Query: 4563 SRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTL 4622
++FD LK+ E M E S+L + I+ N LTL
Sbjct: 1058 ------KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111
Query: 4623 ----QRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY---KVQEAILARKE 4675
+R Q + L ++ + + + L K K Y IL
Sbjct: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 1171
Query: 4676 YASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQ 4735
+ +I Q ++ + + + A + + L+ IL+ + L E EL++
Sbjct: 1172 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE----YILETWSHLDEDQQELSR 1227
Query: 4736 KKEGFRSTGQ-----PWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK----- 4785
+ E S+ D+++ +TLY LK SL E YQ +
Sbjct: 1228 QLEVVESSIPSVGLVEENEDRLIDRITLYQHLKS------SLNEYQPKLYQVLDDGKRLL 1281
Query: 4786 ---MCQQLERQLKSVKE----EQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4838
C LE QL + E +K+++E E LK + D L+
Sbjct: 1282 ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDR 1341
Query: 4839 LEDLAPH--LDPLAYEKARHQIQSWQGELKLL--TSAIGETVTECESRMVQSIDFQTEMS 4894
LE P E R + ++ K + S++ +V +++++ T
Sbjct: 1342 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 1401
Query: 4895 RSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ-------EEVQSSLRIMNALSHK 4947
RS L R+ ++ + L N+ +QE++ ++Q+ + EV S + +M + K
Sbjct: 1402 RS--ELSRIDSQWTD---LLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQK 1456
Query: 4948 EKEKFTKA----------------------KELISADLEHSLAELSELDGDIQEALRTRQ 4985
+++ + K+L + S+ ++S D E+ R+ +
Sbjct: 1457 DEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQD---VESKRSDK 1513
Query: 4986 ATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESA-EENLKSHMEFFSTEDQ 5044
E + +Q+ Q E +QL L+ S E N++ +F T+++
Sbjct: 1514 TDFAEQLGAMNKSWQILQGL------VTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 1567
Query: 5045 FHSNLEELHSL------------VATLDPLIKPTGKE-------------DLEQKVASLE 5079
L++ H + L+ LIK KE + ++ V+S+
Sbjct: 1568 ---RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIV 1624
Query: 5080 LRSQRMSRDSGAQVD--------LLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLK 5131
+ + R + A +D LL+ QW ++ A +++ + + LS F LL
Sbjct: 1625 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL- 1683
Query: 5132 TSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQR 5191
T S + ++ + L + + +QL K + TL+ ++ V R
Sbjct: 1684 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 1743
Query: 5192 WTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDK----LPGSSAEKASKAEL 5247
W L +Q + + + W + + K+ + Q +D+ L ++ + + E+
Sbjct: 1744 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEV 1803
Query: 5248 LTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DGAAPTPGEEPPLMQEITAMQDR 5303
T ++ + + L + +L L + + Q A+ ++ L Q + A++
Sbjct: 1804 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 1863
Query: 5304 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQIL 5363
Q ++ + D E + +++ W+ E +E L + L +Q
Sbjct: 1864 LCKQQTSLQAG-------VLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQ-- 1914
Query: 5364 LTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQ- 5422
E+M EE K + L ++ P +L +L E+ L + D+ +++ + +
Sbjct: 1915 -----------ERM-EELKGQMLKFSSMAP-DLD-RLNELGYRLPLNDKEIKRMQNLNRH 1960
Query: 5423 -SKATSQELSR--QIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMEL 5479
S +SQ R ++Q T L K + + +VQ T+QK L E+ G L+E
Sbjct: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQ--TEQK-LAVEISGNYQHLLEQ 2017
Query: 5480 DAAVQKF--------------------LEQNGQLG--KPLAKKIGKLTELHQQTIRQAEN 5517
A + F L + GQ+ K+ L+ Q IR+A+
Sbjct: 2018 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQ 2077
Query: 5518 RLSKLNQAASHLEEYNEMLELILKWIEKAKVL-----------------AHGTIAWNSAS 5560
R ++ + Y EM E + KW+ + L + +
Sbjct: 2078 RRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV 2137
Query: 5561 QLREQ--YIL-----HQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRET 5613
LR+Q YIL Q LL ++ L+A ++Q EK L +
Sbjct: 2138 FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQ--------EKWKSASMRLEEQK 2189
Query: 5614 EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQ 5673
++L ++K + + A ++K KKL +L L + ++ L+ +
Sbjct: 2190 KKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWT 2249
Query: 5674 HLLSEMESLKPKVQAVQLCQSALRIPEDVVASL-----PLCH-AALRLQEEASRLQHTAI 5727
L+++ LK + A + + I + V L LCH +LR Q+ RL A+
Sbjct: 2250 DDLTQLSLLKDTLSA-YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 2308
Query: 5728 QQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQK 5787
+ ++ K L + + ++E K +I EE+ +K
Sbjct: 2309 ---------------FSEKNKELCEWL----TQMESKVSQNGDI--------LIEEMIEK 2341
Query: 5788 I-KGYQEQIA-SLNSKCKMLTM-----KAKHATMLLTVTEVEGLAEGTEDLDGELLPTPS 5840
+ K YQE+IA + +K ++ M KA H + +E+E D LL +
Sbjct: 2342 LKKDYQEEIAIAQENKIQLQQMGERLAKASHES---KASEIEYKLGKVNDRWQHLLDLIA 2398
Query: 5841 AHPSVVMMTAGRCHTLLSPVTE-ESGEEGTNSEISSP---PACRSP--SPVANTDASVNQ 5894
A + T L ++ + SE++ P +C S N + +
Sbjct: 2399 ARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR 2458
Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEK 5954
DI + A L +H + + + ++ + +L R W + + E+
Sbjct: 2459 DIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR----NLDRRWRNICAMSMER 2514
Query: 5955 QRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG------RSPESQMAEHQALMD 6008
+ + E QK+ D +++ E + G + + Q +
Sbjct: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 2574
Query: 6009 EILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLL 6068
E L + IN+ LA E ++S +L+ + +R ++ + + + L
Sbjct: 2575 ECLTQLELINKQYRRLARENRTDSA-------CSLKQMVHEGNQRWDNLQKRVTSILRRL 2627
Query: 6069 EEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 6128
+ + QR+E + D + WL T+ L D++A++ +
Sbjct: 2628 KHFIG-----QREE-----FETARDSILVWL--TEMDLQLTNIEHFSECDVQAKIKQLKA 2675
Query: 6129 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQL 6188
EI + ++ E L+ + + E+ +LRR + H K +
Sbjct: 2676 FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI 2735
Query: 6189 NMQGTAQEKEESDVDLTATQSPGVQE--WLAQARTTWTQQRQSSLQQQKELEQELAEQKS 6246
+ E + SD +L S + + W ++ + + SS L Q L ++S
Sbjct: 2736 RLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS-NLSLSLAQPLRSERS 2794
Query: 6247 LLRSVASRG----------------EEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSS 6290
+ AS E + + +E +K L +G+ G+ S+
Sbjct: 2795 GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSA 2854
Query: 6291 AEDQMRMKWESL-HQEFSTKQKLLQNVLEQEQE------------QVLYSRPNRLLSGVP 6337
E Q+R ++L F +Q +N++ + L + + V
Sbjct: 2855 LESQIRQLGKALDDSRFQIQQ--TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 2912
Query: 6338 LYKGDVPTQDKS--------AVTSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDG 6386
+ + +++S + + G+ +E + +Q+ + +Q++ Q+
Sbjct: 2913 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD 2972
Query: 6387 VSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNK------NLF 6440
+++ WL D EE L L E T + E+ K +KE+ + +D K NL
Sbjct: 2973 LNSIWAWLGDTEEELEQLQRL---ELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 3029
Query: 6441 SQAF--PENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNF---QNDLKV 6495
S F ++ ++RD ++D L + GR + S++ + +++ L Q F + L +
Sbjct: 3030 SPEFTQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 3088
Query: 6496 LFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP 6555
+ ++ K I+ +N+ + + + + + Q + L E + L+ +L V
Sbjct: 3089 MLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAE 3148
Query: 6556 SMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6607
L + ++ +IG+R L L S++ + L+ L D+ + Q+
Sbjct: 3149 GTDCLEAKEKVH-----VIGNR---LKLLLKEVSRHIKELEKLLDVSSSQQD 3192
Score = 126 bits (317), Expect = 8e-28
Identities = 548/3098 (17%), Positives = 1187/3098 (38%), Gaps = 401/3098 (12%)
Query: 1236 QYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQ 1295
QY++ +K+ L++LI G+ +E +K + T N+ E Q + H++ ++I + Q+Q
Sbjct: 266 QYEQEMKH-LQQLIEGAH--REIEDKPVATSNIQELQAQISRHEELAQKI----KGYQEQ 318
Query: 1296 IAQAQQGEGGLPDRG-HEELRKLESTLDGLERSRERQERRI--------QVTLRKWERFE 1346
IA L + H + + ++GL E + + V + R
Sbjct: 319 IASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 378
Query: 1347 TNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIA----VQAENLVKE 1402
T V + G++ E SS + S + + IA + AE L +
Sbjct: 379 TLLSPVTEESGEEGTNSE----ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 434
Query: 1403 ASEI----------------PLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1446
A++I P LQ+ +++K + + + TL E ++ + +
Sbjct: 435 AAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
Query: 1447 KWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEE 1506
+ E + + ++E + + E+ + + +I + EI SS L EE
Sbjct: 495 SLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS---LAEE 551
Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHA----QCLEGTILGHLSQQQKFEENLR 1562
S + E +++ LT + +R A Q LE + L +Q++ E+ L+
Sbjct: 552 LVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQ-EQALQ 610
Query: 1563 KIQQSVSEFEDKL----AVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARK 1618
+ + E + L A S E + + MD L + + A S +
Sbjct: 611 RYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELS-- 668
Query: 1619 VVNRDSCVQEAAALQQQYEDI---LRRAK----ERQTALENLLAHWQRL--EKELSSF-L 1668
V N + ++ A + + E + LRR K E Q AL + + Q EKE S L
Sbjct: 669 VHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDL 728
Query: 1669 T---------WLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQL 1719
T WL + + + ++E EL ++L V S+
Sbjct: 729 TATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA 788
Query: 1720 KESLFSVASKDDVKMMKLHLE--------QLDERWRDLPQIINKRINFLQSVVAEHQQFD 1771
E+ K DV +L +E Q+ +W L Q + + LQ+V+ + Q+
Sbjct: 789 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQE-- 846
Query: 1772 ELLLS----FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHL 1827
++L S + L+ ++ T + ++ L + + EV S+ G + HL
Sbjct: 847 QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFE---EVSSQSGGAKRQSIHL 903
Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
+ G + L E +LF + + E + L + + +S + +
Sbjct: 904 EQKLYDGVSATSTWLDDVEE---RLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 960
Query: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947
+ N + D+IE L L L+S + + + ++ +
Sbjct: 961 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020
Query: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
+ AD ++++ N+ +Q A+ + +++A +D +E I +++ R DK +++
Sbjct: 1021 FTSLADNKYIILQKLANVF--EQPVAEQIEAIQQA-EDGLKEFDAGIIELKRRGDKLQVE 1077
Query: 2008 EPTRQALQQRLRVFNQLEDELNSHEHEL---CWLKDKAKQIAQKDVAFAPEVDREINRLE 2064
+P+ Q L + ++++L + S L LK + ++ Q D+A E +E +
Sbjct: 1078 QPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ-DLADLLETGQE----K 1132
Query: 2065 VTWDDTKRLIHENQGQCCGLIDLMREY-QNLKSAVSKVLENASSVIVTRTTIKDQEDLKW 2123
+ D +++I ++ + L+D +EY Q L+S + + E I++ K+ +
Sbjct: 1133 MAGD--QKIIVSSKEEIQQLLDKHKEYFQGLESHMI-LTETLFRKIISFAVQKETQFHTE 1189
Query: 2124 AFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSE 2183
++ + + + +L+ HL + +++ S +V++ + S
Sbjct: 1190 LMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL-SRQLEVVESSIPSV--------G 1240
Query: 2184 KLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESE 2243
+EEN DRL ++++ + S+ +E + + + ++ +L + E
Sbjct: 1241 LVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECW 1300
Query: 2244 VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFT 2303
+ N +ELH LK T+ Q ADL+ L+ AK+ E
Sbjct: 1301 LSNTNKMSKELHRLETILKHWTR-------YQSESADLIHWLQSAKDRLEFWTQQSVTVP 1353
Query: 2304 AQSTQVEKFINDITTWFTKVE-ESLMNCAQNETCEALKKVKDIQKE-LQSQQSNISSTQE 2361
+ V +N + +V+ +S + + T L ++K + L+S+ S I S
Sbjct: 1354 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWT 1413
Query: 2362 ----NLNSLCRKYHSAELESLG--RAMTGLIKKHEAVSQLCSKTQASLQESLE-KHFSES 2414
N+ ++ K H +++ L A++ ++ + + K + +++ S+ K E
Sbjct: 1414 DLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEY 1473
Query: 2415 MQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY 2474
+Q+++ + + K+ + + VL+ D+++ +D +L A+ + Q L
Sbjct: 1474 LQKYKGFKIDINC--KQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQ 1531
Query: 2475 AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEM 2534
++++I + E + ++ E++ + QCLK FE Q ++L H +
Sbjct: 1532 GLVTEKI--QLLEGLLESWSEYENNV-QCLKTW------------FETQEKRLKQQ-HRI 1575
Query: 2535 EERFNTENLGESKQHIPE----KKNEVHKVEMFLGELLAARES------LDKLSQRGQLL 2584
++ + +N + Q + + K+ EV K+E L+ ++ + L + GQ
Sbjct: 1576 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTW 1635
Query: 2585 SEEGHGAGQEGRLCSQLL---TSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVK 2641
+ H GQ L +L +SH+ L + +L L +L+++ V
Sbjct: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV- 1694
Query: 2642 AIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQR 2701
D L + L ++ ++ I + LL + V + E +R +N +
Sbjct: 1695 ---DNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751
Query: 2702 VIQTQL-ETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK-------NQLEQWMESVD 2753
Q Q + L ++W S ST++ + N+ ++ +++ W++ +
Sbjct: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCN 1811
Query: 2754 QKIE------------HPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSR--- 2798
++ H L Q + +QS H AL + + K +
Sbjct: 1812 DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSL 1871
Query: 2799 -------ELYEKTED--ESFKDTAQEELKTQ----FNDIMTVAKEKMRKVE-EIVKDHLM 2844
E + K+ + E++ A+E L+ Q +D+ T+ +E+M +++ +++K M
Sbjct: 1872 QAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI-QERMEELKGQMLKFSSM 1930
Query: 2845 Y--LDAVHEFTDWLHSAKEELHRWSDMSGD----SSATQKKLSKIKELIDSREIGASRLS 2898
LD ++E L +E+ R +++ SS T ++ SK++ + + +
Sbjct: 1931 APDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990
Query: 2899 RVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQ-MALSEQE 2957
+ +Q ++ RA + ++ +F Q L +++ L EQ
Sbjct: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAH-ELFQAEMFSRQQILHSIIIDGQRLLEQ- 2048
Query: 2958 FSGQVAQLEQALEQFSALLKTWAQQLTLLEGKN--TDEEIVECWHKGQEILDALQK---- 3011
GQV ++ + + L W + + + D +I + W + +E+ + L+K
Sbjct: 2049 --GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQ-WQRYREMAEKLRKWLVE 2105
Query: 3012 -----------AEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN 3060
+ ++ +E+ + G ++ L L A G +
Sbjct: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA 2165
Query: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTA-------KCFD-IPQNISEVSTSLQKIQEFLS 3112
Q ++ ++ L K A KC I ++ ++ T +K+ + L
Sbjct: 2166 ALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 2225
Query: 3113 ESENGQHKLNMMLSKGE------------------LLSTLLTKEKAKGIQAKVTAAKEDW 3154
+ H M + E LS ++ + + +V + W
Sbjct: 2226 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQW 2285
Query: 3155 KNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQ 3214
+ L + + + F + + +WL++ E V ++ D+ + ++
Sbjct: 2286 EELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG----DILIEEMIEK 2341
Query: 3215 KLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS--FRHRVSQLSSQYLALSNLTKEKV 3272
+ EEI + +L++ ++L + SK+ +++ +++ ++ L +L +V
Sbjct: 2342 LKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 2401
Query: 3273 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDS-RTLKLEALLSVKQ 3331
+L + Q + L+ W+ H+ P V DS + +++ L+ +Q
Sbjct: 2402 KKLKETLVAVQQLDKNMSSLRTWLA---HIESELAKPI----VYDSCNSEEIQRKLNEQQ 2454
Query: 3332 EKEIQMKMIVTRGESVLQN-----------TSPEGIPTIQQQLQSVKDMWASLLSAGIRC 3380
E + ++ T SVL + +IQQ +++ W ++ + +
Sbjct: 2455 ELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 2514
Query: 3381 KSQLEGALSKWTSYQDGVRQFSGWMDSMEANL--------------NESERQHAELRDKT 3426
+ ++E W + D +F W+ S E E ++ A R
Sbjct: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 2574
Query: 3427 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3486
L + +L+N++ Y L A + V + +R+ +Q+R + +
Sbjct: 2575 ECLTQLELINKQ---YRRLARENRTDSACSLKQMV-----HEGNQRWDNLQKRVTSILRR 2626
Query: 3487 SEKLVRLHQEYQRDLKAFEVWLGQ---EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCA 3543
+ + +E++ + VWL + + ++ +S + A ++ L+ Q +
Sbjct: 2627 LKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK-----IKQLKAFQQEIS 2681
Query: 3544 EGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLM 3603
+ ++ E +I P + +E + + Y + +++ + +L L
Sbjct: 2682 LNHNKIEQIIAQGEQLIEKSEP-LDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLP 2740
Query: 3604 EQKFQQVDEWL---------------KTAEEKVSP-----------------RTRRQSNR 3631
+ + D L ++A+ +SP R+ R +
Sbjct: 2741 DDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPA 2800
Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQAL 3689
+ I L +W + RD +E +RA DE + + A L+ + AL
Sbjct: 2801 SVDSIPL----EWDHDYDLSRD-LESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSAL 2855
Query: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749
Q+ + K L++ ++++E+ + S + ++K + + + + +K
Sbjct: 2856 ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSI--DSVKR 2913
Query: 3750 LEVLLKDMEK---GHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRK 3806
LE LK+ E+ G L S + + E +A+ L KE+
Sbjct: 2914 LEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR--------------- 2958
Query: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE--EPKMELYEKKAQLSKYKSLQQ 3864
+++ L ++F+ ++ W+ + +E L + E ++ + Q+ K K LQ+
Sbjct: 2959 ----MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQK 3014
Query: 3865 TVLSHEPSVKSVREKGEALLEL--VQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
V + + S+ + + L+D++ Q+ + +CS+ +E L+ +
Sbjct: 3015 AVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM 3074
Query: 3923 DHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME---EIAGFEDR 3979
+ ++ E+ +L+ R + S+L+ Q HHK +M+ E+ + R
Sbjct: 3075 QCQGFH-EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ-DHHKQLMQIKHELLESQLR 3132
Query: 3980 LNNLQMKGDTLI--GQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 4037
+ +LQ L+ + D L+AK K H+ G + + R + LE L
Sbjct: 3133 VASLQDMSCQLLVNAEGTDCLEAKEK----VHVIGNR--LKLLLKEVSRHIKELEKLLDV 3186
Query: 4038 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQ 4075
S+QD +W SA + D S P R+ +Q
Sbjct: 3187 SSSQQDL----SSWSSADELDTSGSVSPTSGRSTPNRQ 3220
Score = 107 bits (267), Expect = 5e-22
Identities = 376/2167 (17%), Positives = 804/2167 (37%), Gaps = 284/2167 (13%)
Query: 432 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 491
Q++ + IQ+ L++HK+ Q ++H ++R + Q E
Sbjct: 1137 QKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAV-----QKETQFHTELM 1191
Query: 492 VSSTSELHLMKMEFLELKYRLLSLLVLAESK---------LKSWIIKYGRRESVEQLLQN 542
+++ L +EL+Y L + L E + ++S I G E E L +
Sbjct: 1192 AQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLID 1251
Query: 543 YVSFIEN--SKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE 600
++ ++ S E YQ+L + + S E++ +N+ W + + +
Sbjct: 1252 RITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQ-----LNQLGECWLSNTNK 1306
Query: 601 VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 660
+ LE ++ +W RY + A L WL+ A+ L +F+ + Q M
Sbjct: 1307 MSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL--------EFWTQQSVTVPQELEM 1358
Query: 661 -NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT 719
D N +E E+ ++ + +L G +V E+ R+ ++TD +
Sbjct: 1359 VRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTN 1418
Query: 720 LSAFATEAHK----------KLSEPLEVSFMNVKLLIQDLEDIEQRVPV----------- 758
+ A + H+ +SE + + ++ +D ++I+ +
Sbjct: 1419 IPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYK 1478
Query: 759 ---MDAQYKIIT-----------KTAHLITKESPQEEGKEMFATMSK----LKEQLTKVK 800
+D K +T + + +K S + + E M+K L+ +T+
Sbjct: 1479 GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKI 1538
Query: 801 ECYSPLL-----YESQ-QLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQK 854
+ LL YE+ Q L E +++ +G + L+ L K K
Sbjct: 1539 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAK 1598
Query: 855 HQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQT--RLQRQIADIHVAFQSMV 912
+E+ ++N L LI+ + V V + L+ QT L + + + +S++
Sbjct: 1599 EKEVEKIEQN---GLALIQNKKEDVSSIV--MSTLRELGQTWANLDHMVGQLKILLKSVL 1653
Query: 913 KKTGDWKKHVETNSRLMKKFEESRAELEK---------VLRIAQEGLEEKGDPEELLRRH 963
+ W H ++ E+R L + +++ + L+ D E R
Sbjct: 1654 DQ---WSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS 1710
Query: 964 TEFFSQLDQRVLNAFLKAC-----DELTDILPE------------QEQQGLQEAVRKLHK 1006
+ F + N LK C + LT+ L E EQ +A+ +L +
Sbjct: 1711 LQKFGS----ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQ 1766
Query: 1007 QWKDLQGEAPYHLLHLK------IDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKE 1060
++KD + + + + N+ +A +E T + L+ G+ +K+
Sbjct: 1767 RYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD-DEVATWIQDCNDLLKGLGT---VKD 1822
Query: 1061 HRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLM 1120
F H L E+ Q ++ D + + C L A+ L
Sbjct: 1823 SLFFL-----HELGEQLKQQVDASAASAIQSDQLSLSQHLC-----ALEQALCKQQTSLQ 1872
Query: 1121 EDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGET 1180
++ + +WI E L+G + +++ ++ +EE++ + K
Sbjct: 1873 AGVLDYETFAKSLEALEAWIVEAEEILQG--QDPSHSSDLSTIQERMEELKGQMLKFSSM 1930
Query: 1181 LSWLKSRLKVLTEVSSENEAQKQGDEL--------AKLSSSFKALVTLLSEVEKMLSNFG 1232
L ++ + ++ K+ L ++ + F L + L + + L
Sbjct: 1931 APDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990
Query: 1233 DCVQYKEIVKNSLEELISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKK 1289
+++ + L ISG+ + Q++A ++ E +F QQ+L +R+
Sbjct: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAE-MFSRQQILHSIIIDGQRL---- 2045
Query: 1290 RDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNK 1349
+QG+ D + +L L + G+ R +++ I +R+W+R+
Sbjct: 2046 ---------LEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 2096
Query: 1350 ETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLV---KEASEI 1406
E + ++L + +L S L S+ L+Q RT VQ + V ++ S I
Sbjct: 2097 EKLRKWLVEVS-----YLPMSGLGSVPIPLQQA-----RTLFDEVQFKEKVFLRQQGSYI 2146
Query: 1407 PLGPQNKQL-----------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNF 1455
KQL LQ + I+E+ K LEE K + + W+
Sbjct: 2147 LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGI 2206
Query: 1456 -ETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFV 1514
++L T K+K +L + + + K + S + L + + ++
Sbjct: 2207 ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYI 2266
Query: 1515 TTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDK 1574
+ + + + ++ ++R EEL I L++ F E +++ + +++ E K
Sbjct: 2267 SADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESK 2326
Query: 1575 LAV--PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAAL 1632
++ I I + K QE + + Q + + A A + +
Sbjct: 2327 VSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKV 2386
Query: 1633 QQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKV 1692
+++ +L R L+ L Q+L+K +SS TWL E++ + P + S + ++
Sbjct: 2387 NDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEI 2446
Query: 1693 EGELQLIQALQNEVVSQASFYSKLLQLKESLF----SVASKDDVKMMKLHLEQLDERWRD 1748
+ +L Q LQ ++ ++ + +L L E L + A+ + ++ LD RWR+
Sbjct: 2447 QRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRN 2506
Query: 1749 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLF--LSELQTTSEISIMDHQVALTRH 1806
+ + +R ++ Q+F + F W+K + ++S + + L +
Sbjct: 2507 ICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKF 2566
Query: 1807 KDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQ----LFEEASQVVER 1862
+ +V +L+ + +L R + L+ + Q L + + ++ R
Sbjct: 2567 EAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR 2626
Query: 1863 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDL------IEKDLNDALQNA 1916
+ + EF + S+ L ++ ++ TN + +E D+ ++ + N
Sbjct: 2627 LKHFIGQREEFETARDSILVWLTEM--DLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH 2684
Query: 1917 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADAL 1976
+E + ++ K++ E+ R ++ G VER L D
Sbjct: 2685 NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH 2744
Query: 1977 AVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQ---ALQQRLRVFNQLEDELNSHEH 2033
+ + + + L + + D +P+ +L Q LR D S +
Sbjct: 2745 DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 2804
Query: 2034 -ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQ 2092
L W D + +++ ++R + D+ + + G + L ++
Sbjct: 2805 IPLEW---------DHDYDLSRDLESAMSRALPSEDEEGQ--DDKDFYLRGAVGLSGDHS 2853
Query: 2093 NLKSAVSKV----------LENASSVIVTRTTIKDQEDLKW-AFSKHETAKNKMNYKQKD 2141
L+S + ++ ++ ++I ++T + D + + K + K
Sbjct: 2854 ALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKR 2913
Query: 2142 LDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDD 2201
L++ + + L +HS++ T +D+W + + R++ +L W
Sbjct: 2914 LEHKLKEEEESLPGFVNLHSTE-----TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ 2968
Query: 2202 VLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDL 2261
S + I W + ++ + L+ EL + ++ ++ + +L+EL V+
Sbjct: 2969 FNSDLNSIWAWLGDTEEELEQ--------LQRLELSTDIQT-IELQIKKLKELQKAVDHR 3019
Query: 2262 KE--LTKNLETPP----------DLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQV 2309
K L+ NL +P DLQ + + + + + E +G L+D Q
Sbjct: 3020 KAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGF 3079
Query: 2310 EKFINDITTWFTKVE---ESLMNCAQNETCEAL----KKVKDIQKELQSQQSNISSTQEN 2362
+ + + ++ ++ N E L K++ I+ EL Q ++S Q+
Sbjct: 3080 HEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQD- 3138
Query: 2363 LNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQE------SLEK--HFSES 2414
C+ +AE T ++ E V + ++ + L+E LEK S S
Sbjct: 3139 --MSCQLLVNAE-------GTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSS 3189
Query: 2415 MQEFQEW 2421
Q+ W
Sbjct: 3190 QQDLSSW 3196
Score = 92.4 bits (228), Expect = 2e-17
Identities = 385/2080 (18%), Positives = 783/2080 (37%), Gaps = 278/2080 (13%)
Query: 481 QLEDMAERFHFVSSTSELHLMKMEFLELKYR-----LLSLLVLAESKLKS-WIIKYGRRE 534
+L+DM + + + L + L+ +Y L LL + K+ I +E
Sbjct: 1086 KLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE 1145
Query: 535 SVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQW 594
++QLL + ++F+ E ++ IL +T + + +E + + M + +A
Sbjct: 1146 EIQQLLDKH------KEYFQGLE-SHMILTETLFRKIISFAVQKETQFHTELMAQASAVL 1198
Query: 595 RNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPH-W 653
+ R V LE ++ W L LE E + +++ R +
Sbjct: 1199 KR--AHKRGVE--LEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT 1254
Query: 654 IQQH--TAMNDAGNFLIETCDE-------MVSRDLKQQLLLLNGRWRELFMEVKQYAQAD 704
+ QH +++N+ L + D+ + DL+ QL L W L K +
Sbjct: 1255 LYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECW--LSNTNKMSKELH 1312
Query: 705 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYK 764
++ + K +T + SA + + LE + Q+LE + + K
Sbjct: 1313 RLETILKHWTR-YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK 1371
Query: 765 IITKTAHLITKESPQEEGKEMF----ATMSKLKEQLTKVKECYSPLLYESQQLLIPLEEL 820
+ + L K S G ++ + L+ +L+++ ++ LL + L +L
Sbjct: 1372 EVDAQSSL--KSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQL 1429
Query: 821 EKQMTSFYDSLGKINEIITVLEREAQ-------SSALFKQKHQEL-----LACQENCKKT 868
+ ++ ++ I+++E Q +S +K H+ L NCK+
Sbjct: 1430 QMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQL 1489
Query: 869 LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGD----------- 917
++ +QSV + + K D+T Q+ ++ ++Q + +
Sbjct: 1490 T--VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLES 1547
Query: 918 WKKHVETNSRLMKKFEESRAELEKVLRIA-----QEGLEEKGDPEELLRRHTEFFSQLDQ 972
W ++ L FE L++ RI Q L++ D E+L++ + +++Q
Sbjct: 1548 WSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 1607
Query: 973 RVLNAFLKACDELTDILPE------QEQQGLQEAVRKLHKQWKDLQGEAPYH-------- 1018
L ++++ I+ Q L V +L K + + H
Sbjct: 1608 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 1667
Query: 1019 --LLHLKIDVEKNRFLA-SVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCE 1075
L+ + + + R L S+E + ++D L Q+ EK + + F S
Sbjct: 1668 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNL--QDDLEKQERSLQKFGSITN------ 1719
Query: 1076 KRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK---DYTSR 1132
QL++E PV +T TLKE+ ++ ++ E K R
Sbjct: 1720 ---QLLKEC------HPPVTETLTN---TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQR 1767
Query: 1133 FSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWL---KSRLK 1189
+ ++S ++ Q + E + A + ++ A +E+ + + L L K L
Sbjct: 1768 YKDYSKQCASTVQQQEDRTNELLKAATNKDI--ADDEVATWIQDCNDLLKGLGTVKDSLF 1825
Query: 1190 VLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE-EL 1248
L E+ + + Q + + S +L L +E+ L C Q + L+ E
Sbjct: 1826 FLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQAL-----CKQQTSLQAGVLDYET 1880
Query: 1249 ISGSKEVQE----QAEKILDTENLFEAQQL--LLHHQQKTKRISAKKRDVQQQIAQAQQG 1302
+ S E E +AE+IL ++ + L + ++ K K + + + +
Sbjct: 1881 FAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 1940
Query: 1303 EGGLP--DRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTG 1360
LP D+ + ++ L + + ++Q L + + F ET + +L QT
Sbjct: 1941 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTE 2000
Query: 1361 SSHERFLSFSSLESLSS----ELEQTKEFSKRT--ESIAVQAENLVKEASEIPLGPQNKQ 1414
+S + L EL Q + FS++ SI + + L+++ N +
Sbjct: 2001 QKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 2060
Query: 1415 L--LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNAL 1472
L L Q + + + ++ ++ I+ +W + E L W+ E ++ L
Sbjct: 2061 LTLLSNQWQGVIRRAQQRRGIIDSQIR-------QWQRYREMAEKLRKWLVE----VSYL 2109
Query: 1473 ETSS-SAMDMQISQIKVTIQEIESK-------LSSIVGLEEEAQSFAQFVTTGESARIKA 1524
S ++ + + Q + E++ K S + E + +G A ++A
Sbjct: 2110 PMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQA 2169
Query: 1525 KLTQIR--------RYGEELREHAQCL---EGTILGHLSQQQKFEENLRKIQQSVSEFED 1573
+L +I+ R E+ ++ A L E G +K +K+ QS+ + +
Sbjct: 2170 ELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE 2229
Query: 1574 KLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAF-SASARKVVNRDSCVQEAAAL 1632
+L C E + D L L ++A+ SA ++N + L
Sbjct: 2230 ELHAEQMRCK---ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN-----ERVELL 2281
Query: 1633 QQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKV 1692
Q+Q+E++ + R+ + L W ++ WL + E+K S + D +
Sbjct: 2282 QRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ-----NGDILIE 2336
Query: 1693 EGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQI 1752
E +L + Q E+ +L Q+ E L + + ++ L ++++RW+ L +
Sbjct: 2337 EMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 2396
Query: 1753 INKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAE 1812
I R+ L+ + QQ D+ + S W+ SEL + ++ E
Sbjct: 2397 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK-----------PIVYDSCNSEE 2445
Query: 1813 VESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAE 1872
++ K E Q LQ + K S G A L+L + DC +A + Q A +L
Sbjct: 2446 IQRKLNEQQELQRDIEK-HSTGVASVLNLCEVLLHDCDACATDAE--CDSIQQATRNLDR 2502
Query: 1873 FLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSK 1932
++ ++S + R +E T + + D + D L++++ + S I +
Sbjct: 2503 RWRNICAMS---MERRLKIEETWRLWQKFLDDYSR-FEDWLKSSERTAAFPSSSGVIYTV 2558
Query: 1933 AQYHLKIGSSEQRT--SCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQD---QK 1987
A+ LK + QR C + + + R+ +++ D+ LK+ + +
Sbjct: 2559 AKEELKKFEAFQRQVHECLTQLELINKQYRRL-----ARENRTDSACSLKQMVHEGNQRW 2613
Query: 1988 EELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDELNSHEH-ELCWLKDKAKQI 2045
+ L K + I R +E A L +++ +L + EH C ++ K KQ+
Sbjct: 2614 DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL 2673
Query: 2046 AQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKV---L 2102
AF E+ N++E ++LI +++ +I+ E L+ +V +
Sbjct: 2674 K----AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE--EELDELRRYCQEVFGRV 2727
Query: 2103 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2162
E ++ D+ DL + ++ +L++ + LS+L S
Sbjct: 2728 ERYHKKLIRLPLPDDEHDL--------------SDRELELEDSAA-----LSDLHWHDRS 2768
Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSI------WDDVLSTRDEIEGWSNNC 2216
SL+ S + L +++ L S+ WD ++E +
Sbjct: 2769 ADSLLSPQPSSNLS--LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRA 2826
Query: 2217 VP-QMAENISNLDNHLRAEELL----KEFESEVKNKALRLEELHSKVNDLKELTKN-LET 2270
+P + E + D +LR L ES+++ L++ ++ + + ++ T
Sbjct: 2827 LPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPT 2886
Query: 2271 PPDLQ-------------FIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDIT 2317
P+L D +++LEH + E + + + TQ I+
Sbjct: 2887 GPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWE 2946
Query: 2318 TWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELES 2377
+ + QN L+K + +L S + + T+E L L R S ++++
Sbjct: 2947 LLQAQALSKELRMKQN-----LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 3001
Query: 2378 LGRAMTGLIKKHEAVS---------QLCSK--TQASLQES 2406
+ + L + +AV LCS TQA +ES
Sbjct: 3002 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 3041
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
[Homo sapiens]
Length = 6907
Score = 2051 bits (5315), Expect = 0.0
Identities = 1747/6330 (27%), Positives = 2987/6330 (47%), Gaps = 542/6330 (8%)
Query: 2749 MESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--LYEKTED 2806
+ V ++ L+ + KE + Q +L + E LI+K +E + T+
Sbjct: 837 LTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGE----LISKHKEALIISNTKS 892
Query: 2807 ESFKDTAQEELKTQFN-DIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHR 2865
+ A EELK DI +EK R V K ++ HE + ++ K ++ +
Sbjct: 893 LAKYLKAVEELKNNVTEDIKMSLEEKSRDV--CAKWESLH----HELSLYVQQLKIDIEK 946
Query: 2866 WSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC--ELMHTEM 2923
+S + +K+++K K+LI R R + L E + + GC +L H M
Sbjct: 947 -GKLSDNILKLEKQINKEKKLI--------RRGRTKGLIKEHEACFSEEGCLYQLNH-HM 996
Query: 2924 QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQL 2983
+ LR ++ ++Q ++ L+ + +++ L+ + +
Sbjct: 997 EVLRELCEELPSQ--KSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTI 1054
Query: 2984 TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTE-DLKSQLNELCRFSRDLSTYSGKVSG 3042
T E + D + K + EP + L S L L S YS ++
Sbjct: 1055 TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINS 1114
Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
L++ Y+ QN + + F D + AK+T + + +N ++
Sbjct: 1115 LLERYDTYRDILEHHLQNNKFRITSDFSSE-EDRSSSCLQAKLTDLQ---VIKNETDARW 1170
Query: 3103 SLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH 3162
+I E+ K ++ + + L KE+ + +Q + E + +
Sbjct: 1171 KEFEIISLKLENHVNDIKKPFVIKERDTL-----KERERELQMTLNTRMESLETALRLVL 1225
Query: 3163 QKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRRE-----QQKLQ 3217
E A +L + D + IQ + +++ + D AK+ E ++
Sbjct: 1226 PVEKA--SLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGN 1283
Query: 3218 SVLEEIHCYEPQLNR---LKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN-------- 3266
VL+E+H ++ + LK K Q +EG HRV + AL +
Sbjct: 1284 FVLKELHPFDLHAMQNIILKYKTQ--FEGM------NHRVQRSEDTLKALEDFLASLRTA 1335
Query: 3267 -LTKEKVSRL---DRIVAEHNQFSLGIKELQ-DWMTDAIHMLDSYCH------------- 3308
L+ E V+ L D VA+ N ++ KE + M D LD
Sbjct: 1336 KLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGD 1395
Query: 3309 PTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSV-- 3366
TS +++LD+ ++KL ++E + + N + I +Q Q+ +
Sbjct: 1396 DTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGL 1455
Query: 3367 KDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG----WMDSMEANLNESERQHAEL 3422
KD + + +L+ L ++ + +++ + + D E +N+ + L
Sbjct: 1456 KDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVL 1515
Query: 3423 RDKTTML--------GKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYR 3474
+ T L G+ L ++ ++ S+L T+ K + + + ++L++R
Sbjct: 1516 WENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIA 1575
Query: 3475 AIQ------ERAKEAVTKSEKLVRLHQEYQRDLKAFEV-------------WLGQEQEKL 3515
I+ E V K ++ + Q Y +K FE WL ++
Sbjct: 1576 EIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTE 1635
Query: 3516 DQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESL 3575
D Y L G A L +L+ + E +AL LH + EDR E L
Sbjct: 1636 DYYENL-GRALALWDKLFNLKNVIDEWTE-KALQKMELHQLTE---------EDR--ERL 1682
Query: 3576 RQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKE 3635
+++ Q ++ + SE F+ V +++ + Q ++ L+ E + + T E
Sbjct: 1683 KEELQVHEQKTSE----FSRRVAEIQFLLQS-SEIPLELQVMESSILNKMEHVQKCLTGE 1737
Query: 3636 IQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLE 3695
H + E+ R+++++ A+ Q + ES + + + ++ ++ + + Q+L+
Sbjct: 1738 SNCHALSGSTAEL---REDLDQ--AKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQ 1792
Query: 3696 ----------QIKFLEEEIQSLEESESSLS-----------------------SYSDWYG 3722
QI L E+ L++ S+S +++DW+
Sbjct: 1793 QKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFS 1852
Query: 3723 STHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE 3782
+ N K + +V +KL+ L L +E +S +K + K+L +
Sbjct: 1853 NIKVNLKECFESSETKKSVE--QKLQKLSDFLT-LEGRNSKIKQVDSVLKHVKKHLPKAH 1909
Query: 3783 AERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3842
+ L + +L+++ S + LE L D + L +W+ +E
Sbjct: 1910 VKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969
Query: 3843 EEP--KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ 3900
EEP K EL+ + L++ + ++V S+K E E++ + T +D+ Q
Sbjct: 1970 EEPGEKTELFCQA--LARKREQFESVAQLNNSLKEYGFTEEE--EIIMEATCL--MDRYQ 2023
Query: 3901 SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT 3960
+ + L I +E + + + +N +V W+ ++ L+ + E
Sbjct: 2024 TLLRQLSEIEEED----KLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEG------- 2072
Query: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC---ADHLQAKLKQNVHAHLQGTKDSY 4017
K +EE + L+ +GD I A+ +A L Q + D+
Sbjct: 2073 ------KMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNT 2126
Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVK 4077
+ ST + L E +K++ ++ L+ L Q + + Q L +A Q+K
Sbjct: 2127 LHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQ-EAGFALQHGLQEKKA--QLK 2183
Query: 4078 HFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKH 4137
++ ++A+ LL + N ++ T E W EIKH
Sbjct: 2184 IYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEP---------------WLEIKH 2228
Query: 4138 LKSELWIYLQDADQQLQNMKRRHSELEL----------NIAQNMVS---------QVKDF 4178
L L LQD+ Q L R H ++ N ++ VS V++
Sbjct: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEK 2288
Query: 4179 VKKLQS-------KQASVNTIIEKVNKLTKKEESPEHK----EINHLNDQWLDL------ 4221
++KLQ + ++ I+ + + S K +I L + DL
Sbjct: 2289 LQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLAS 2348
Query: 4222 CRQSNNLCLQREEDLQRT-----------RDYHDCMNVVE-----VFLEKFTTEWDNLAR 4265
+Q CL +R+ R+ +V E +EK +W+
Sbjct: 2349 AKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEI--- 2405
Query: 4266 SDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW 4325
+ +AV + K+L+L QE ED + + + L LD L EQ +E+ +
Sbjct: 2406 --NKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTM-LRNEQLEEIEKLY 2462
Query: 4326 FQLEDLIKRKIQVSVTNLEELNVVQSRFQEL--MEWAEEQQPNIAEALKQSPPPDMAQNL 4383
QLE K+ + E LN ++ L + ++ + N+ +AL +Q
Sbjct: 2463 TQLE--AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
Query: 4384 LMDHLAICSELEAKQMLLKSLIKDADRVMADL--GLNERQVIQKALSDAQSHVNCLSDLV 4441
++ L A + +K+L+ D + + + I+K ++ + + L +L
Sbjct: 2521 VLRDFQ--EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLK 2578
Query: 4442 GQRRKYLNKALSEKTQFLMAVFQATS----QIQQHERKIMFREHICLLPDDVSKQVKTCK 4497
+ N + L + + Q++Q +K ++ + D+ + + +
Sbjct: 2579 IKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEY--DEFTTLMNKVQ 2636
Query: 4498 SAQASLKTYQNEV--------------------TGLWA--QGRELMKEVTEQEKSEVLGK 4535
+ SL+ Q + T L A G ++K E + + G+
Sbjct: 2637 DTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGE 2696
Query: 4536 LQELQSVYDSV--LQKCSHRLQELE---KNLVSRKHFKEDFDKACHWLKQADIVTFPEIN 4590
+E +++ D + L+K L+ L +N + + + + W K P I
Sbjct: 2697 -KEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIP 2755
Query: 4591 LMNES--SELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNAL 4648
L+ + S++ + IL + E+L ++ +PSL + S L+ L L
Sbjct: 2756 LLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDK----VPSLTTYEGSDLNNTLEDL 2811
Query: 4649 PRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFL-RMSKVPTDLAVE 4707
Q+ ++V + + +++ + R + ++I + E E + R+ T+ ++
Sbjct: 2812 RNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELK 2871
Query: 4708 EALSLQDGCRAILDEV-AGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQT 4766
+ + L E+ +G+ + EL E + + D++ +L +R++R
Sbjct: 2872 HHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQR-- 2929
Query: 4767 EQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE-ETLPAEEKLKMYHSLAGSL 4825
+++T + + K C+Q + +++EE + E L +E K +L
Sbjct: 2930 -----FIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNL 2984
Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
+D +K + + L D + Q+ Q ++ + E + + ++ +
Sbjct: 2985 KDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEE 3044
Query: 4886 SIDFQTEMS--RSLDWLRR------VKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4937
+Q +S R++D + +KA S P LN Q + + I K + +E+
Sbjct: 3045 HGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKK 3104
Query: 4938 LRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELS--ELDG-DIQEALRTRQAT 4987
L KEK +L + + L++ + ELS ELD + Q+ L T
Sbjct: 3105 LNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHV 3164
Query: 4988 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 5047
L +I SQ Q+ + E+ + + E+ +E + + M
Sbjct: 3165 LNQIKSQLQQPLLI----------NLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEK 3214
Query: 5048 NLEELHSLVATLDPLIKPTGKEDLEQKV-ASLELRSQRMSRDSGAQVDLLQRCTAQWHDY 5106
EE S + ++ ++ EDL+ ++ S++LR+ ++ D + T Y
Sbjct: 3215 QREENSSEASDVETKLREF--EDLQMQLNTSIDLRTNVLN-------DAYENLTR----Y 3261
Query: 5107 QKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKA 5166
++A +E + E + + + + E L + + L S V +++
Sbjct: 3262 KEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTV-------AHIQDLT 3314
Query: 5167 SQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEM 5226
+L + +K L ++ + + + ++ + QE E ++ + + +
Sbjct: 3315 EKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTN 3374
Query: 5227 IDQLQDKLPGS-SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAP 5285
+ +++ L S S+ S E L LE V L + L LRQ L +L+
Sbjct: 3375 LSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQ-ILRLLR--LRC 3431
Query: 5286 TPGEEPPLMQEITAMQDRCLNMQE----------KVKTNGKLVKQELKDREMVETQINSV 5335
T + L++ ++A+ ++ L++ E ++K K V +E++ ++ +
Sbjct: 3432 TENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEE 3491
Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK---MAEEQKEKYLGLYTIL 5392
+ +TKE A EEL LL + +N+EK + ++ + +
Sbjct: 3492 LPEISKTKEA---------ATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVP 3542
Query: 5393 PSELSLQLAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK 5451
S +++ ++ ++++ +++V+++K Q ++ K++ + +
Sbjct: 3543 ESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602
Query: 5452 TDNVVQ-AKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQ 5510
T + A D E+ + S L + + +E K K +E++
Sbjct: 3603 TTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIME----------KLRIKYSEMYTI 3652
Query: 5511 TIRQAENRLSKLNQAASHLEEY--NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYIL 5568
+ E+++ + +A ++E NE+L+ + + K+ N L+++
Sbjct: 3653 VPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKN 3712
Query: 5569 HQTLLEESKEIDSELEAMTEKLQYLTSVY--CTEKMSQQVAELG-------RETEELRQM 5619
+ E K++ EL+ KL L S E+ Q E ++ +++ Q
Sbjct: 3713 IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQR 3772
Query: 5620 IKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM 5679
+ R L A M+++ LK +A +E L +P LSH H +
Sbjct: 3773 AECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSH--HASTVQ 3828
Query: 5680 ESLKPKVQAVQLCQSALRIPED---VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAA 5736
+L+ Q L S ED + + L + L + + LQ ++ +Q
Sbjct: 3829 MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRM 3888
Query: 5737 VVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIA 5796
E E+K +++ + + K + + +E + E + + I+ ++ IA
Sbjct: 3889 ADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE---HLKHGEVILENIRPMKKTIA 3945
Query: 5797 SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL 5856
+ S L + L L + + L+ V+ T +
Sbjct: 3946 EIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEI 4005
Query: 5857 --LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS--AERLQTDAA 5912
L + + + +S A + P + Q ++ Q L+
Sbjct: 4006 ENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVL 4065
Query: 5913 KIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSL 5972
+H QE E P+ T++ G + + SE++ ++ ++ +
Sbjct: 4066 NLHQHLKQEQEGVERDRLPAVTSEEGGVA------ERDASERKLNRRGSMSYLAAVEEEV 4119
Query: 5973 QSISTKMEAIELKLSESPEPGRS---PESQMAEHQALMDEILMLQD---EINELQSSLAE 6026
+ S K + + K SP+ S + M E +A ++Q+ +I+ +S+A+
Sbjct: 4120 EESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQ 4179
Query: 6027 ELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL-LEEKLNDQLEEQRQE--Q 6083
L +S + + +L+ T E +T ++A + L ++E+ R E +
Sbjct: 4180 ILTPDSLNTEQGPECSLRPNQT---EEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
Query: 6084 ALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSEL 6143
L + + EL+ WL ++ +E QL+ CQ ML EIE KV L E
Sbjct: 4237 VLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLET 4296
Query: 6144 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6203
++ L T+ EAE L+ KL+ +K +L ++Q L +K Q K+ S+ +
Sbjct: 4297 C---KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPE 4353
Query: 6204 LTATQSPGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 6262
P L T Q RQ QQQ+ LE + EQK ++ + +++ Q+
Sbjct: 4354 HQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQY 4413
Query: 6263 SAAE--TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQE 6320
+ T+ ++ S E + S + Q KW+ LH E S+K KL L +
Sbjct: 4414 CQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEP 4473
Query: 6321 QEQVLYSRPNRLLSGVPLYKGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHL 6379
Q S +L V +Y PT ++ T+ L+ L Q + +Q + I+L
Sbjct: 4474 Q----VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINL 4529
Query: 6380 EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL 6439
++KL++ S L VEE L + L E+ + E LA ++K++ + K
Sbjct: 4530 DKKLFELFLTLSQCLSSVEEMLEMPR-LYREDGSGQQVHYETLALELKKLYLALSDKKGD 4588
Query: 6440 FSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 6499
+A G+N +++ + L L + R +K L ++QN++K L+
Sbjct: 4589 LLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQ 4648
Query: 6500 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 6559
L +K + Q L + Q VAEQ++ L+ ++ + +L+ G++L + +QE
Sbjct: 4649 LIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE 4708
Query: 6560 LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSS 6619
+ KL+D+ D + ++ +R + L+ +SQ + LQ + +L++ G+EK+A S
Sbjct: 4709 VYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKS 4768
Query: 6620 KEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 6679
K +Q ++ HK +FQ L + M+L + KI+ +Q F E + + + +++ +
Sbjct: 4769 KVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQ 4828
Query: 6680 RGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSL 6739
G++L+ +L+ W DE+ L + LE++ S++PSV LVEE E+RL++RI+ YQ +K ++
Sbjct: 4829 CGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
Query: 6740 NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR 6799
+LYQ L++GK+L+ S+SC +LE Q+ +L E WLS K+ ELHRL+ +LKH
Sbjct: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS 4948
Query: 6800 YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV 6859
Y +S L WL+S++ L +W +QS+ V Q+L+ +R ++N F EFSKEVD +SSLK++V
Sbjct: 4949 YNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAV 5008
Query: 6860 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEV 6919
+S GNQLL LK+ DTATLR+ L++ + +WT L+T +P +QEKLHQLQM+KLPSR AI+E+
Sbjct: 5009 ISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
Query: 6920 MSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISS 6979
+SW++ +E+ DED++ + + LQK+K F+++++ KQ VDFVNQS+LQ+S+
Sbjct: 5069 ISWMNNVEHQTS-DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLST 5127
Query: 6980 QDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFE 7039
DVESKR ++T+FAE LG MN+ W + G++ KIQ LE LLES +E EN +Q L W E
Sbjct: 5128 CDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLE 5187
Query: 7040 TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI 7099
QE+RLK + SVQ L DCQD+E+ + K K +++++Q+ L L ++ +
Sbjct: 5188 AQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL-ESGAVPLLED 5246
Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL 7159
S + EL Q +++ V QLK ++SVL +W + +D++N + Y + + +
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
Query: 7160 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 7219
SLE ++ QV+NLQ+LQD+ E E S +K + +L C P V E + + + R
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTHKR 5365
Query: 7220 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEV 7279
W + + IA+QLQ +++LLQLW+ Y + + A+ ++QQE + +L + + + + +
Sbjct: 5366 WTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL 5425
Query: 7280 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7339
+QD +L + K++ + ++L Q ++S + SL Q LE+
Sbjct: 5426 PPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-QRAAYLEKM 5484
Query: 7340 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQ 7399
L + + + ++ F LE+L+ I+ EE L D H + +E +
Sbjct: 5485 LLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---DRLHQQE----KENPDSFLNH 5537
Query: 7400 MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ 7459
+L ++ +PD++ LNE+ +LPL+D +K +QN+NR W ++ ER S+LQ L ++
Sbjct: 5538 VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGL-NE 5596
Query: 7460 TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQ 7519
FL CE W++ L + E+ L V+++ + LLEQQ+ +++ +AE+ Q I S +
Sbjct: 5597 KFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSL 5656
Query: 7520 RLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL 7579
+LL+ ++++R EF + + L+++WQ ++ +QR+G +D +RQWQ + E L ++L
Sbjct: 5657 QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFL 5716
Query: 7580 VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA 7639
+ S+L + G L Q R+L E++ KE F R++ + LT+EAG++LLL+ D
Sbjct: 5717 TDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKT 5776
Query: 7640 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7699
+ ++ ++++Q+ WK +L E K+ ++ W++CEK I + +L+ K +
Sbjct: 5777 KESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP 5836
Query: 7700 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
LP+ HE+LH E+ KELE ++ SWT +L +L +K L+ ++ +D+ +L E++E L R
Sbjct: 5837 LPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHR 5896
Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
QWE+LC ++++R+Q+I +RLN W VF+EKNKELC WL QME+KV Q DI IEEMIEKL+
Sbjct: 5897 QWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQ 5956
Query: 7820 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 7879
KD EEI + ENK+QL+QMG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKK
Sbjct: 5957 KDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKK 6016
Query: 7880 LKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKH 7939
LKET +QQLDKNMS+LRTWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+H
Sbjct: 6017 LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQH 6076
Query: 7940 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 7999
S GV SV N+C+VLLHD DACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWR
Sbjct: 6077 SAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWR 6136
Query: 8000 LWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELI 8059
LWQKFLDDYSRFEDWLKS+ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELI
Sbjct: 6137 LWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELI 6196
Query: 8060 NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 8119
NKQYRRLARENRTD+A LKQMVHEGNQRWDNLQ+RVT++LRRL+HF QREEFE R+S
Sbjct: 6197 NKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRES 6256
Query: 8120 ILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8179
ILVWLTEMDLQLTN+EHFSE D K++QL FQQEI+LN NKI+Q+I GEQLI+KSEP
Sbjct: 6257 ILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEP 6316
Query: 8180 LDAAIIEEELDELRRYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDL 8238
LDA +IE+EL+EL RYCQEVFGRV R+H++L P +DE + S+ E ++ED +
Sbjct: 6317 LDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTD 6376
Query: 8239 HWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL------S 8292
W R S +PSS SL ERSG +TP SVDSIPLEWDH D+
Sbjct: 6377 SWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHE 6432
Query: 8293 RDLESAMSRALPSEDEEGQDDKDFYLR---GAVGLSGDHSALESQIRQLGKALDDSRFQI 8349
D E AL D E ++ + YL+ + S S + + +
Sbjct: 6433 EDEEGPYYSAL--SDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCPEHHY 6490
Query: 8350 QQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
+Q E R+ P P T YK G + L + + L ++E+ L G
Sbjct: 6491 KQMEG-DRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE 6549
Query: 8407 LHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQL 8466
Q +G DRWE++QAQ L +L++KQNL QQ NSD+++I WL TE ELE L
Sbjct: 6550 ------QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEML 6600
Query: 8467 QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQ 8526
+ + +DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q
Sbjct: 6601 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6660
Query: 8527 MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAE 8586
++ W+ ++ WRG L+ +LMQCQ FH++S LLL L + R+ + D D
Sbjct: 6661 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6720
Query: 8587 ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLL 8646
L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI +LK L
Sbjct: 6721 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6780
Query: 8647 KEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLS 8706
++VS + L+ + +Q S S DE+D SG P + S
Sbjct: 6781 EQVS------QDLMALQGTQNPASPLPSFDEVD-SGDQPPAT-----------------S 6816
Query: 8707 QPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVP 8766
P P R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+ LACL+P
Sbjct: 6817 VPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 6876
Query: 8767 MSEEDYSCALSNNFARSFHPMLRYTNGPPP 8796
SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 6877 SSEEDYSCTQANNFARSFYPMLRYTNGPPP 6906
Score = 608 bits (1569), Expect = e-173
Identities = 1245/6222 (20%), Positives = 2449/6222 (39%), Gaps = 953/6222 (15%)
Query: 21 LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
LQ EQE QK+ FT WINS LA+ P V+ DLF D+K G LL LLEVLSGQ+LP ++G
Sbjct: 25 LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84
Query: 81 RRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTS 140
+ NI AL FL R IKL+NI+ TDI DG PSI+LGL+WTIIL+F IE+L
Sbjct: 85 SNTFQCRI--NIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
Query: 141 NLPQLQSLSSSASSVDSIVSSETPSPPSKR--KVTTKIQGNAKKALLKWVQYTAGKQTGI 198
L S V + SS SPP+K+ KV + Q +A+KALL W Q +
Sbjct: 143 TL-SCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESV 201
Query: 199 EVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDP 258
V DF SWR+G+AF ++IHA+RP+L+D+++VK RSN++NL +AF IAE EL IPRLL+P
Sbjct: 202 NVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEP 261
Query: 259 EDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRV 318
EDVDV PDEKSIMTYVAQFL++ D + Q + G+ +
Sbjct: 262 EDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQK----------- 310
Query: 319 IFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKL 378
++++ ++ E D KY S F + ++K ++ +L
Sbjct: 311 --EKLQKLLKDSEND---------TYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDEL 359
Query: 379 SLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEET 438
D ++++WD + ++ W I+L+ +LP PL AWL E + E+++ Q H +
Sbjct: 360 DKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQA 419
Query: 439 ANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIP-VPPDQLEDMAERFHFVSSTSE 497
IQ K+ K L+ + H + + N +P VPP++LE+M R + + +
Sbjct: 420 VTLIQEKMTLFKSLMDRFEHHSNIL-LTFENKDENHLPLVPPNKLEEMKRRINNI--LEK 476
Query: 498 LHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYE 557
++ +EF K +L L+ +SKL W IKYG RESVE LL+++ FIE +F + +
Sbjct: 477 KFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLD 536
Query: 558 VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDR 617
++Q + E+Y G + + +R + +V+S L++V++ W
Sbjct: 537 TSFQ---KCGEIYKNLAGECQNINKQYMMVKSDVCMYRK---NIYNVKSTLQKVLACWAT 590
Query: 618 YGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSR 677
Y + L+A E+ +K E K+ F L W +H +N+AGNFL+E +++V
Sbjct: 591 YVENLRLLRACFEETKK-----EEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGS 645
Query: 678 DLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEV 737
+ ++L LN RWR+L + + LE
Sbjct: 646 SISKELRRLNKRWRKLVSKTQ------------------------------------LE- 668
Query: 738 SFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP--QEEGKEMFATMSKLKEQ 795
MN+ L+I+ +Q P D I++K + S E E + K E+
Sbjct: 669 --MNLPLMIK-----KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEK 721
Query: 796 LTKVKECYSPLL---YESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFK 852
K E ++ L + ++L+ +E E + S D +++ T +E +
Sbjct: 722 HEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQ----DDVDTSMEESLKHLIAKG 777
Query: 853 QKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMV 912
EL+A E+ +++ Q++ + +VL Q ++Q + + ++V
Sbjct: 778 SMFDELMARSED------MLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQI---NVV 828
Query: 913 KKTGDWKK--HVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQL 970
K K V + + K EES+ ELE + AQ+ L ++ P EL+ +H E
Sbjct: 829 KLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIIS 888
Query: 971 DQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNR 1030
+ + L +LKA +EL + + E + L+E R + +W+ L E ++ LKID+EK +
Sbjct: 889 NTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGK 948
Query: 1031 FLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPV 1090
++ + ++++E KL+ + ++ +IKEH FS++G + ++++ ELC +LP
Sbjct: 949 LSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPS 1008
Query: 1091 RDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGI 1150
+ ++ LK+ I+ + E + S+ I+T+E +
Sbjct: 1009 QKSQQEVKR----LLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP 1064
Query: 1151 KGEA--IDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELA 1208
EA + N ++A+E T+ + S VL + E+ +K D A
Sbjct: 1065 HSEAPFAKSDNQPSTEKAME----------PTMKF--SLASVLRPLQEESIMEK--DYSA 1110
Query: 1209 KLSSSFKALVTLLSEVEKMLSN---------------FGDCVQYK----EIVKNSLE--- 1246
++S + T +E L N C+Q K +++KN +
Sbjct: 1111 SINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARW 1170
Query: 1247 ---ELIS--------------------GSKEVQEQAEKILDT--ENLFEAQQLLLHHQQK 1281
E+IS KE + + + L+T E+L A +L+L ++
Sbjct: 1171 KEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKA 1230
Query: 1282 TKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRK 1341
+ + + + Q DR ++ LR ++ ++ R E L++
Sbjct: 1231 SLLLCGSDLPLHKMAIQGFHLIDA--DRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKE 1288
Query: 1342 WERFETN--KETVVRYLFQ-TGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
F+ + + +++Y Q G +H S +L++L L + E + + +
Sbjct: 1289 LHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSAS 1348
Query: 1399 LVKEASEIPLGPQNKQ----LLQQQAKSIKEQVKKL----------EDTLEEDIKTMEMV 1444
+ A E L +NK+ L++ +AK + + +K L +DT E++ +
Sbjct: 1349 DTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSI 1408
Query: 1445 KTKWDH-FGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKV---TIQEI 1493
K H +G E TE+ K L N L + + QIS+I + T+ +
Sbjct: 1409 KLSETHGYGVQEE-----FTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAV 1463
Query: 1494 ESKLSSIV--------------GLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREH 1539
+ + S++ L+E A S F E + + +
Sbjct: 1464 KHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALV 1523
Query: 1540 AQCLE--GTILGHLSQQQKFEENLRKI---QQSVSEFEDKLAVPIKICSSATETYKVLQE 1594
+CLE G +L L Q Q F+ L + ++SV + + E V +E
Sbjct: 1524 TECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEE 1583
Query: 1595 HMDLCQALESLSSAI--TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALEN 1652
+ + ++ ++ F + K +EA + ++ DI + ++ L
Sbjct: 1584 FNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGR 1643
Query: 1653 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
LA W +L + W E+ K ++ DR +++ ELQ+ + +E + +
Sbjct: 1644 ALALWDKLFNLKNVIDEWTEKALQKMELHQL-TEEDRERLKEELQVHEQKTSEFSRRVAE 1702
Query: 1713 YSKLLQLKESLFSVASKDDVKMMKL-HLEQ--------------LDERWRDLPQIINKRI 1757
LLQ E + + + K+ H+++ E DL Q +I
Sbjct: 1703 IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQ-AKTQI 1761
Query: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA--------LTRHKDH 1809
+S++ D L + F+ ++ LQ + ++++Q+ L + +
Sbjct: 1762 GMTESLLKALSPSDSLEI-FTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYES 1820
Query: 1810 AAEVESKKGELQSLQGHLAKL--GSLGRAED-LHLLQGKAEDCFQLFEEASQVVERRQLA 1866
+++ + K + LQ H +KL D ++ ++CF+ E V ++ Q
Sbjct: 1821 VSDLFNTKKSV--LQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKL 1878
Query: 1867 LSHLA---------------EFLQSHASLSGILRQLRQTVEATNSMNKNES--DLIEKDL 1909
L + ++ H + + + V + K ES K+L
Sbjct: 1879 SDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKEL 1938
Query: 1910 NDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTK 1969
D+LQ L+ +L L+ + K G E L + E+ +++
Sbjct: 1939 EDSLQQLLRLQDDHRNLRKWLTNQEEKWK-GMEEPGEKTELFCQALARKREQFESVAQLN 1997
Query: 1970 QS-------EADALAVLKKAFQDQKEELLKSIEDIEER-----TDKERLKEPTR------ 2011
S E + + + D+ + LL+ + +IEE T+ + +
Sbjct: 1998 NSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI 2057
Query: 2012 QALQQRLRVFNQLEDELNSHEH-----ELCWLKDKAKQ-----IAQKDVAFAPEVDREIN 2061
+ +++ L V N E ++ E E+ LK + + Q + + AP V + +
Sbjct: 2058 KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLT 2117
Query: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDL 2121
+ WD+T L + + L K L++ + + +K +++
Sbjct: 2118 DISNQWDNTLHLAS----------TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEA 2167
Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTV--DKWL 2179
+A +H + K + K F K + L S LK++ S L++ + + WL
Sbjct: 2168 GFAL-QHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWL 2224
Query: 2180 DVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKE 2239
++ + L E++ + Q+ +++ NLD H+R
Sbjct: 2225 EI-KHLHESL---------------------------LQQLQDSVQNLDGHVR------- 2249
Query: 2240 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTL 2299
E + + + +L++ +++ + + P Q + +QKL+ + + GTL
Sbjct: 2250 ---EHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTL 2306
Query: 2300 KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISST 2359
K A + V++ + + K + + C Q KD++ L S + +
Sbjct: 2307 KKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQ----------KDLENRLASAKQEMECC 2356
Query: 2360 QENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQ-ESLEKHFSESMQEF 2418
LNS+ + S E + T ++ +A S + TQ S E LE+ + +
Sbjct: 2357 ---LNSILKSKRSTEKKG---KFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSA 2410
Query: 2419 QEWFLGAKAA--AKESSDRTGDSKVLEAKLHDLQN---ILDSVSDGQSKLDAVTQEGQTL 2473
E + + + A+ES T D E K+++LQN LD++ + +E + L
Sbjct: 2411 VEMAMSKQLSLNAQESMKNTED----ERKVNELQNQPLELDTMLRNEQ-----LEEIEKL 2461
Query: 2474 YAHLSKQ---IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLW 2530
Y L + I Q + E L Q L + L + +
Sbjct: 2462 YTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV 2521
Query: 2531 IHEMEE-----RFNTENLGESKQHIP----EKKNEVHKVEMFLGELLAARESLDKLSQRG 2581
+ + +E + + L K+ + + + K++ F+ + ++SL L +
Sbjct: 2522 LRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKW 2581
Query: 2582 QLLSEEGHGAGQEGRL----CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQ--- 2634
+ LS H + +L QL + + + ++K V E L +Q
Sbjct: 2582 ENLS--NHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
Query: 2635 -SMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGEGEVKLNMAIGKGEQ 2690
S+ + +Q RL E G++ + + ++KG+ E+++ G+ E
Sbjct: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKE- 2698
Query: 2691 ALRSSNKEGQRVIQTQLETLKE----------------------VWADIMSSSVHAQSTL 2728
+ + ++G ++ Q ETL+ +WA + ++ L
Sbjct: 2699 --KKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPL 2756
Query: 2729 --ESVISQ-------WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSI 2779
+ ++SQ + + R+ +E E V K+ P E L + L+ +
Sbjct: 2757 LPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV-----PSLTTYEGSDLNNTLEDL 2811
Query: 2780 LSEAEDHTRALHRLIAKSRELYEKTEDES--FKDTAQEELKTQFNDIMTVAKEKMRKVEE 2837
++ + + + +S++L K E+ S F + +L Q ++ + + + + E
Sbjct: 2812 RNQ---YQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEA 2868
Query: 2838 IVKDHLMYLDAVHEFTDWLHSA-KEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASR 2896
+K H + L+A + + S L +++ + + ++ +++ + + +I +R
Sbjct: 2869 ELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF--LEDQLKNLKIRTNR 2926
Query: 2897 LSR-VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSE 2955
+ R +++ EV+ C H + AL+ + DS+ + + L V++ E
Sbjct: 2927 IQRFIQNTCNEVEHK--IKFCRQFHEKTSALQEE----ADSIQRNELLLNQEVNKGVKEE 2980
Query: 2956 QEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQ-KAEP 3014
+ L+ L + L +L+ K + I W Q LD LQ +
Sbjct: 2981 ------IYNLKDRLTAIKCCI------LQVLKLKKVFDYIGLNWDFSQ--LDQLQTQVFE 3026
Query: 3015 RTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFR 3074
+ ++L+ ++ +L F + GK L+ + + LQ K + + R
Sbjct: 3027 KEKELEEKIKQLDTFEEE----HGKYQALLSKMRAIDLQIKK--MTEVVLKAPDSSPESR 3080
Query: 3075 DFQQWLVNAKITTAKCF--DIPQNISEVST--SLQKIQEFLSESENGQHKLNMMLSKGEL 3130
+++ +I AKC +I + ++E T K +E L N + + +
Sbjct: 3081 RLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNM 3140
Query: 3131 LSTLLTKE-KAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ-MKDFEVSAEPIQD- 3187
+ L KE K Q K+ + S L Q L NL+I+ +++ + + E Q+
Sbjct: 3141 VLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ--PLLINLEIKHIQNEKDNCEAFQEQ 3198
Query: 3188 -W--------LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI---------HCYEPQ 3229
W ++ EK E+S+ D+ K RE + LQ L YE
Sbjct: 3199 VWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYE-N 3257
Query: 3230 LNRLKEKAQQLWEGQAASKSF------------------RHRVSQLSSQYLALSNLTKEK 3271
L R KE + E + ++ + +L S + +LT EK
Sbjct: 3258 LTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLT-EK 3316
Query: 3272 VS-------------RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY-CHPTSDKSVLD 3317
+ L +V++++ K + T+A L++Y C+ ++ +
Sbjct: 3317 LGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE---TEAERYLENYKCYRKMEEDIYT 3373
Query: 3318 S------------RTLKL---EALLSVKQEKEIQMKMIVTRGESV----------LQNTS 3352
+ +L L EAL ++Q K + +I T+ E + L+ T
Sbjct: 3374 NLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTE 3433
Query: 3353 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
+GI + + + ++ + W SLL A + E +W + + + + +D+++ L
Sbjct: 3434 NDGI-CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEEL 3492
Query: 3413 NE--------SERQHAELRDKTTMLG----KAKLLNEEVLSYSSLLETI-EVKGAGMTE- 3458
E + + +EL D G K +LL +L ++ + E GA T
Sbjct: 3493 PEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVP 3552
Query: 3459 --HYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQ 3510
+T ++ LQ +Q+ +Q +E + +++++ L +Q+ +F+ Q
Sbjct: 3553 AFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQ 3612
Query: 3511 EQ-EKLDQYSVLEGDAHTHETTLRDLQE-LQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
+ EK +Q+ L+ + T ++ E L++ +E ++ + + ++ + + +
Sbjct: 3613 DHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDID 3672
Query: 3569 DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQ 3628
++ + + +Y M +K ++++ L E+ + +Q
Sbjct: 3673 EKISNEVLKSSPSY-------------------AMRRKIEEINNGLHNVEKML-----QQ 3708
Query: 3629 SNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT-SRYQ 3687
++ ++ Q Q K W +E+ + ++ E+ + Q+I+++ ++ + +YQ
Sbjct: 3709 KSKNIEKAQEIQKKMW-DELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQ 3767
Query: 3688 ALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKL 3747
+ + + L + +EE L S W +T N A D + T +
Sbjct: 3768 QVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPA-DYDSLRT--LSHHA 3824
Query: 3748 KTLEVLLKDMEKGHSLLKSA-REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRK 3806
T+++ L+D E+ H+LL S + + ++ + E + L + I + Q+ L + +
Sbjct: 3825 STVQMALEDSEQKHNLLHSIFMDLEDLSIIF----ETDELTQSIQELSNQVTALQQKIME 3880
Query: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE----EPKMELYEKKAQLSKYKSL 3862
+++ + K++ + +++ + IL E P+ L + L + +
Sbjct: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPM 3940
Query: 3863 QQT---VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEA 3919
++T ++S++ ++ + + G L + Q + +QL D + L ++ +E L+
Sbjct: 3941 KKTIAEIVSYQVELR-LPQTGMKPLPVFQ------RTNQLLQDIKLLENVTQEQNELLKV 3993
Query: 3920 KVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME-EIAGFED 3978
+K +++ E++ +++ L S + SLE ++ A ++ EI E
Sbjct: 3994 VIKQTNEWDEEIENLKQILNNYSAQF---------SLEHMSPDQADKLPQLQGEIERMEK 4044
Query: 3979 RLNNL-QMKGDTLIGQCADHLQAKLKQNVHAHLQG-----TKDSYSAICS----TAQRMY 4028
++ +L Q K D L+ A L N+H HL+ +D A+ S A+R
Sbjct: 4045 QILSLNQRKEDLLVDLKATVL------NLHQHLKQEQEGVERDRLPAVTSEEGGVAER-- 4096
Query: 4029 QSLEHELQKHVSR------QDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL 4082
+ E +L + S ++ +++ EPSPQ S + K ++ RA
Sbjct: 4097 DASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRAS 4156
Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL------------VQAQNL-- 4128
+ + N+ + D TEQ E L ++A L
Sbjct: 4157 SSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDS 4216
Query: 4129 --TQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELEL-----NIAQNMVSQVKDFVKK 4181
QG E + K+ + + L K + +ELEL N+A + D +
Sbjct: 4217 SDAQGGLEPRVEKTR-----PEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQV 4271
Query: 4182 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRD 4241
L+ + ++ ++ EHK + L + D N E L
Sbjct: 4272 LEQQLVGCQAMLTEI----------EHK-VAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320
Query: 4242 YHDC-MNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALA-----LQERKYAIEDL 4295
C + V++ L++ +E + S H EAL+ + L+ + ER
Sbjct: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380
Query: 4296 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL----EDLIKRKIQVSVTNLEELNVVQS 4351
Q+Q+++E ++ K+ +K + ++ W Q D + + + E +V S
Sbjct: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440
Query: 4352 ----RFQELMEWA---EEQQPNIAEALKQSPPPDMAQNL--------------------- 4383
+ Q +W E I L Q P ++ N+
Sbjct: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500
Query: 4384 ----LMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSD 4439
L D S L+ ++ + + + D+ + +L L Q + + D
Sbjct: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560
Query: 4440 LVGQRRKY---------LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVS 4490
GQ+ Y L ALS+K L+ + + +CL +
Sbjct: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620
Query: 4491 KQVKTCKSAQASL---KTYQNEVTGLWAQGRELMKEVT--EQEKSEVLGK--LQELQ--S 4541
++ KS +A L ++YQNE+ L+ Q L+K T +Q +E+ G+ ++LQ
Sbjct: 4621 AVCRS-KSLKAGLDYNRSYQNEIKRLYHQ---LIKSKTSLQQSLNEISGQSVAEQLQKAD 4676
Query: 4542 VYDSVLQKCSHRLQELEKN---------LVSRKHFKED-FDKACHWLK------------ 4579
Y L+ R+ +L L+ + ED D L+
Sbjct: 4677 AYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVT 4736
Query: 4580 --QADIVTFPEINLMNESSE--LHTQLAKYQNILEQSPEYENL----------LLTLQRT 4625
Q D + + L+ E H L + ++ + + EN +L +Q
Sbjct: 4737 ESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
Query: 4626 GQTILPSLNEVDHSYLSEK------LNALPRQFNVIVALAKDKFYKVQEAILARKEYASL 4679
ILPSL + ++ +E+ L RQ + + K+ + E + ++ +
Sbjct: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
Query: 4680 IELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEG 4739
+ T S+S +E R+ VE Q R I + A L + LN+ K+
Sbjct: 4857 LISTLPSVSLVEETEERL--------VERISFYQQIKRNIGGKHARLYQT---LNEGKQL 4905
Query: 4740 FRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKE 4799
S P ++ L + L ++ + + L+ + + QL + L+S +
Sbjct: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQH 4965
Query: 4800 EQSKVNEETLPAEEKLKMYHSLAGSL------QDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
+ E++L + L S + D LK I + + HL
Sbjct: 4966 TLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT 5025
Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELS--GPV 4911
R + ++ + +L + + + + ++ + + ++ + W+ V+ + S V
Sbjct: 5026 LRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSV 5085
Query: 4912 YLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFT---KAKELISADLEHSLA 4968
+ + ++ ++K + + E+ I++ ++ + T ++K + L
Sbjct: 5086 HSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLG 5145
Query: 4969 ELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESA 5028
E++ + L + L ++ Q N+WLE +E L+ V S
Sbjct: 5146 EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISV 5205
Query: 5029 EENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTGK--EDLEQKVASLELRS 5082
++ L + + L+EL TL+ PL++ T ++L QK +S+ +
Sbjct: 5206 QKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQV 5265
Query: 5083 QRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5142
++ +Q +W Y + +EV +M E S S ++
Sbjct: 5266 NQLKTS-------MQSVLQEWKIYDQLYDEV-NMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
Query: 5143 SEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQ 5202
++L S L+E +L+ ++ + T +RWT++ DQ
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNT-HKRWTQVNQAIADQ 5376
Query: 5203 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELE 5262
+ + + W ++N +A + Q + K + S L +L + EL+
Sbjct: 5377 LQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQ 5436
Query: 5263 QQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQEL 5322
Q S+L P P E M + L+ ++ K++ +
Sbjct: 5437 HDVQKTKEAFLQNSSVLD--RLPQPAESSTHM-----LLPGPLHSLQRAAYLEKMLLVKA 5489
Query: 5323 KDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQK 5382
+ E V +Q + +LE L+ L+ + + + +E
Sbjct: 5490 NEFEFVLSQFK------------------DFGVRLESLKGLIMHEEENLDRLHQQEKENP 5531
Query: 5383 EKYLGLYTILPSELS--LQLAEVALDLKIRD----QIQDKIKEVEQSKATSQELSRQIQ- 5435
+ +L L ++ L EV+L L + D +Q+ ++ ++ AT+ E ++Q
Sbjct: 5532 DSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQG 5591
Query: 5436 ------------KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAV 5483
K + L I LK N + +Q+ K++E + ++
Sbjct: 5592 IGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQK--------TYKMLEAEVSI 5643
Query: 5484 QK-----FLEQNGQL-------GKP-LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5530
+ ++ Q+ QL +P + KLT+ Q ++ R ++ +
Sbjct: 5644 NQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQ 5703
Query: 5531 EYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQT--LLEE--SKEIDSELEAM 5586
++ +E + +++ L SA + +E++ L+QT L+ E +KEI +
Sbjct: 5704 DFTTSVENLFRFLTDTSHLL-------SAVKGQERFSLYQTRSLIHELKNKEIHFQRRRT 5756
Query: 5587 T--------EKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
T EKL T + E + +++++L +++ + ++ Q + + E
Sbjct: 5757 TCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCE 5816
Query: 5639 AELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEME 5680
++K+L++ L+ +A P L E L + + L+ E+E
Sbjct: 5817 KKIKELKSRLQVLKAQSEDP---LPELHEDLHNEKELIKELE 5855
Score = 117 bits (292), Expect = 7e-25
Identities = 313/1701 (18%), Positives = 680/1701 (39%), Gaps = 250/1701 (14%)
Query: 1237 YKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQI 1296
Y+ +K +LI +Q+ +I + Q + QK + + + + ++
Sbjct: 4638 YQNEIKRLYHQLIKSKTSLQQSLNEI--------SGQSVAEQLQKADAYTVELENAESRV 4689
Query: 1297 AQAQ-QGEG-GLPDRGHEELRKLESTLD---GLERSRERQERRIQVTLRKWERFETNKET 1351
A+ + +GE LP +E+ KLE LD G+ R+R + VT + +
Sbjct: 4690 AKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
Query: 1352 VVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR--TESIAVQAENLVKEASEIPLG 1409
+V+ + + +H S +L +++E K F ++ + + +QA + A +P
Sbjct: 4750 LVK-IGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYS----AKILPSL 4804
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
QN++ + + +VK LE+ + ++ + KW+ F N+ +L EK+L
Sbjct: 4805 LQNRETFWAEQVT---EVKILEEKSRQCGMKLQSLLQKWEEFDENYASL-------EKDL 4854
Query: 1470 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1529
L ++ ++ + ++E E +L E SF Q + + A+L Q
Sbjct: 4855 EILISTLPSVSL--------VEETEERLV-------ERISFYQQIKRNIGGK-HARLYQT 4898
Query: 1530 RRYGEELREHAQC--LEGTILG----HLSQQQKFEENLRKIQQ------SVSEFEDKLAV 1577
G++L C LEG I LS +K + L ++Q S + D+L
Sbjct: 4899 LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTK 4958
Query: 1578 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1637
++ +K ++ +++ Q L+++ S I F +++V + S ++ Q
Sbjct: 4959 WLESSQHTLNYWK--EQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ-- 5014
Query: 1638 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1697
L KE TA L A + E++ + +T L + K +M+ R + +
Sbjct: 5015 --LLHLKETDTA--TLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070
Query: 1698 LIQALQNEVVSQASFYSK--------LLQ------------------LKESLFSVASKD- 1730
+ ++++ + S +S LLQ + +SL +++ D
Sbjct: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130
Query: 1731 -----DVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
+ HL +++ +W + ++N++I L+ ++ + + + + W++
Sbjct: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
Query: 1786 SELQTTSEI-SIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1844
L+T + S++ Q L +D ++ K L L+ L S + LL+
Sbjct: 5191 ERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA----VPLLED 5246
Query: 1845 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQ-TVEATNSMNKNESD 1903
A +LF++ S V+ + + + LQ + ++ T+ M ++
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
Query: 1904 LIEKD-LNDALQNAKALESAAVSLDGILSKAQYHLK------------IGSSEQRTSCRA 1950
++ + L ++N ++L+ A S +G K Q + I Q T R
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
Query: 1951 TA--DQLCGEVERIQNLLGT---------------KQSEA--DALAVLKKAFQDQKEELL 1991
T + ++++ Q+LL KQ EA LA + + + E L
Sbjct: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
Query: 1992 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC----WLKDKAKQIAQ 2047
+++DI+E + + T++A Q V ++L S H L +A + +
Sbjct: 5427 PALQDIKEL---QHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
Query: 2048 KDVAFAPEVDREINRLE---VTWDDTKRLI-HENQGQCCGLIDLMREYQNLKSAVSKVLE 2103
+ A E + +++ + V + K LI HE + +L R +Q K L
Sbjct: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE-------NLDRLHQQEKENPDSFLN 5536
Query: 2104 NASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSD 2163
+ ++ I+ ++ + A + + T+ SEL+ I ++
Sbjct: 5537 HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE 5596
Query: 2164 FSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAEN 2223
L +KW+ + EK+EE L+V ++ N +P++ E
Sbjct: 5597 KFLY------CCEKWIQLLEKIEE---ALKVDVA-----------------NSLPELLEQ 5630
Query: 2224 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ 2283
++ K E+EV + ++ L + T+ +E P+ + L
Sbjct: 5631 ----------QKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE-IENRPEFITEFSKLTD 5679
Query: 2284 KLEHAKEITEVAKGTL-------KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETC 2336
+ ++A + KG + +DFT + +F+ D + L++ + +
Sbjct: 5680 RWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS--------HLLSAVKGQER 5731
Query: 2337 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2396
+L + + + EL++++ + + + C A + L +T +K E+V +
Sbjct: 5732 FSLYQTRSLIHELKNKEIHF----QRRRTTCALTLEAGEKLL---LTTDLKTKESVGRRI 5784
Query: 2397 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK-------LH-D 2448
S+ Q S ++ +E +E +++FQ K+ + +VL+A+ LH D
Sbjct: 5785 SQLQDSWKD-MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHED 5843
Query: 2449 LQNILDSVSDGQSKLDAVTQ---EGQTLYAHLSKQI----VSSIQEQITKANEEFQAFLK 2501
L N + + + + L + TQ E QT+ A L++ + V ++EQI + +++
Sbjct: 5844 LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903
Query: 2502 QCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER-FNTENLGESKQHIPEKKNEVHKV 2560
+ KQ ++D + F +++++L W+ +ME + T ++ + +K+ + ++
Sbjct: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEI 5963
Query: 2561 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2620
+F L ++ D+L + S + A + +L +++ Q+L + +++ +
Sbjct: 5964 NLFSENKLQLKQMGDQLIKA----SNKSRAAEIDDKL-NKINDRWQHLFDVIGSRVKKLK 6018
Query: 2621 VALQEHEALEEALQSMWFWVKAIQDRLAC-AESTLGSKDTLEKRLSQIQDILLMKGEGEV 2679
+ L++ + ++ W+ I+ L+ + ++KRL++ QD+ +
Sbjct: 6019 ETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSA 6078
Query: 2680 KLNMAIGKGEQALRSS----NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2735
+ + L S N+ IQ +L W +I + S+ + +E W
Sbjct: 6079 GVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLW 6138
Query: 2736 NDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
+++ ++ E W++S ++ P + VL + L E R +H +
Sbjct: 6139 QKFLDDYSRFEDWLKSAERTAACPNSSE-------VLYTSAKEELKRFEAFQRQIHERLT 6191
Query: 2796 K---SRELYEKTEDESFKDTA 2813
+ + Y + E+ DTA
Sbjct: 6192 QLELINKQYRRLARENRTDTA 6212
Score = 105 bits (262), Expect = 2e-21
Identities = 352/1983 (17%), Positives = 759/1983 (38%), Gaps = 301/1983 (15%)
Query: 1211 SSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE----ELISGSKEVQEQAEKILDTE 1266
+ K T L ++ + SN E +L+ EL + E++L+
Sbjct: 4495 TEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMP 4554
Query: 1267 NLF--EAQQLLLHHQQ---KTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1321
L+ + +H++ + K++ D + + +A G + E L+ L
Sbjct: 4555 RLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1381
+ + + + + ++ L ++ + + L ++ +S ++ L+ S +S++ +L++
Sbjct: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQK 4674
Query: 1382 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1441
++ E+ + L E + L ++ ++V KLED L+
Sbjct: 4675 ADAYTVELENAESRVAKLRDEGERLHL-----------PYALLQEVYKLEDVLDS---MW 4720
Query: 1442 EMVKTKWDHFGSNFETLS------------VWITEKEKELNALETSSS--AMDMQISQIK 1487
M++ ++ S F T S V I +++ L+ + S A+ QI K
Sbjct: 4721 GMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHK 4780
Query: 1488 VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTI 1547
V Q++ ++ ++ ++ + + ++T+++ E+ R+ L+
Sbjct: 4781 VFFQKL---VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL- 4836
Query: 1548 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE---- 1603
L + ++F+EN +++ + + L + S ET + L E + Q ++
Sbjct: 4837 ---LQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
Query: 1604 SLSSAITAFSASARKVVNRDSCVQ---EAAALQQQYEDILRRAKERQTALENLLAHWQRL 1660
+ + +++V SC + + A L++Q+ + ++ L+ LL H
Sbjct: 4890 GKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSY 4949
Query: 1661 EKELSSFLTWLERGEAKAS---SPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1717
++ WLE + + +++S D + + EV ++S + ++
Sbjct: 4950 NRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVI 5009
Query: 1718 QLKESLFSVASKDDVKMMKLHLEQLDERWR----DLPQIINKRINFLQSVVAEHQQFDEL 1773
+ L + + D ++ L Q +++W LP I K + + E+
Sbjct: 5010 SIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
Query: 1774 LLSFSVWIKLFLSELQTTSEISIMDHQVA------LTRHKDHAAEVESKKGELQSLQGHL 1827
+ W+ E QT+ E S+ A L +HK+ E++ K+ + + L
Sbjct: 5069 IS----WMNNV--EHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
+L + + S+ ER + A HL E + + G+L +
Sbjct: 5123 LQLSTC--------------------DVESKRYERTEFA-EHLGEMNRQWHRVHGMLNRK 5161
Query: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947
Q +E L++ E+ L+ L + LK + Q+
Sbjct: 5162 IQHLE------------------QLLESITESENKIQILNNWLEAQEERLK---TLQKPE 5200
Query: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
+ +L + + I+N L K AL LK+++ + + +ED R D+ K
Sbjct: 5201 SVISVQKLLLDCQDIENQLAIKSK---ALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
Query: 2008 -----------EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEV 2056
+ + Q++ Q ++++QL DE+N + + +K + +V
Sbjct: 5258 RSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
Query: 2057 DR------EINRLEVTWDDTKRLIHENQGQCCGLIDLMRE--------YQNLKSAVSKVL 2102
+ E E +W+ + +I + +G C + +++ E + + A++ L
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
Query: 2103 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2162
+ A S++ + A K + AK + L N + G +L +E+
Sbjct: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQ------LANISMSGNNL-AEILPPALQ 5430
Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2222
D ++ D++ T + +L S L DRL E ++ +P
Sbjct: 5431 DIKELQHDVQKTKEAFLQNSSVL----DRLP-------------QPAESSTHMLLPGPLH 5473
Query: 2223 NISNLDNHLRAEELLK--EFE---SEVKNKALRLEELHSKV----NDLKELTKNLETPPD 2273
++ +L L+K EFE S+ K+ +RLE L + +L L + + PD
Sbjct: 5474 SLQRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPD 5532
Query: 2274 --LQFIEADLMQK--LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2329
L + A Q +EH E++ K L D ++ Q N W +L
Sbjct: 5533 SFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAVKTLQ-----NMNRQWIRATATALER 5585
Query: 2330 CAQ------NET----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE-SL 2378
C++ NE CE K ++ ++K ++ + +++++ L + Y E E S+
Sbjct: 5586 CSELQGIGLNEKFLYCCE--KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643
Query: 2379 GRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2438
+ + QL T+ + FS+ +Q G + R GD
Sbjct: 5644 NQTIADSYVTQSL--QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR-------QRKGD 5694
Query: 2439 SKVLEAKLHD----LQNILDSVSDGQSKLDAVT-QEGQTLYA-----HLSKQIVSSIQEQ 2488
L + D ++N+ ++D L AV QE +LY H K Q +
Sbjct: 5695 VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRR 5754
Query: 2489 ITKANEEFQAFLKQCLK-DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT--ENLGE 2545
T +A K L D + + + +D + + + EM ++F + E +
Sbjct: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ 5814
Query: 2546 SKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSH 2605
++ I E K+ + ++ + L E + L +L+ E + +L T
Sbjct: 5815 CEKKIKELKSRLQVLKAQSEDPLP--ELHEDLHNEKELIKELEQSLASWTQNLKELQTMK 5872
Query: 2606 QNLLR--------MTKEKLRSC---------QVALQEHE---------ALEEALQSMWFW 2639
+L R + KE++ +VA+++ E E + + W
Sbjct: 5873 ADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAW 5932
Query: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2699
+ +++++ + + ++ +EK + + + E +++L G+Q +++SNK
Sbjct: 5933 LVQMENKVL-QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQM---GDQLIKASNKSR 5988
Query: 2700 QRVIQTQLETLKEVWA---DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2756
I +L + + W D++ S V + I Q + + + L W+ ++ ++
Sbjct: 5989 AAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLD---KNMSNLRTWLARIESEL 6045
Query: 2757 EHPL--------QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES 2808
P+ + Q L E+ L ++ + E L+ S +TE +S
Sbjct: 6046 SKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDS 6105
Query: 2809 FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD 2868
+ T + L ++ +I ++ E+ K+EE + +LD F DWL SA+ +
Sbjct: 6106 IQQTTRS-LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNS 6164
Query: 2869 MSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRA 2928
++ +++L + + R+I RL+++E + + ++ + + Q +
Sbjct: 6165 SEVLYTSAKEELKRFEAF--QRQI-HERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221
Query: 2929 DWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE- 2987
++W++ L+ V+ + + F+ Q + E E L QLT +E
Sbjct: 6222 GNQRWDN--------LQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH 6273
Query: 2988 --GKNTDEEIVECWHKGQEIL--------------DALQKAEPRTEDL-KSQLNELCRFS 3030
+ D+++ + QEI +QK+EP L + +L EL R+
Sbjct: 6274 FSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYC 6333
Query: 3031 RDL 3033
+++
Sbjct: 6334 QEV 6336
Score = 98.6 bits (244), Expect = 2e-19
Identities = 314/1723 (18%), Positives = 639/1723 (37%), Gaps = 255/1723 (14%)
Query: 481 QLEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAESKLKSWI----- 527
+L D ER H + + + K+E L +Y LS + ES+ + +
Sbjct: 4691 KLRDEGERLHLPYALLQ-EVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
Query: 528 -IKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMK- 585
+K G+ + L+ S + E ++V +Q K A+M + S + ++++
Sbjct: 4750 LVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ--KLVADMLLIQAYSAKILPSLLQN 4807
Query: 586 ---FMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQ-------------AWL 629
F E + + L + R L+ ++ W+ + ASL+ + +
Sbjct: 4808 RETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLV 4867
Query: 630 EDAEKMLNQSENAKKDFFRNL-PHWIQQHTAMNDAGNFLIE-TCDEMVSR--DLKQQLLL 685
E+ E+ L + + + RN+ + + +N+ + +C E+ + L++Q L
Sbjct: 4868 EETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLS 4927
Query: 686 LN-------GRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVS 738
LN R + L + Y + + D++ K TL+ + E +S+ L+
Sbjct: 4928 LNKKIDHELHRLQALLKHLLSYNR--DSDQLTKWLESSQHTLN-YWKEQSLNVSQDLDTI 4984
Query: 739 FMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTK 798
N+ + ++++++ + A I + HL KE+ + A + L
Sbjct: 4985 RSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL--KETDTATLRASLAQFEQKWTMLIT 5042
Query: 799 VKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSAL--FKQKHQ 856
L++ Q +P + +M S+ +++ + + +S + QKH+
Sbjct: 5043 QLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHK 5102
Query: 857 ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTG 916
E + +++ +QS+ + T K +++T + +++ + +
Sbjct: 5103 EF---RMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLN 5159
Query: 917 DWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD-QRVL 975
+H+E + + E L L +E L+ PE ++ D + L
Sbjct: 5160 RKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQL 5219
Query: 976 NAFLKACDEL-----------------------------TDILPEQEQQGLQEAVRKLHK 1006
KA DEL + +L + Q L+ +++ + +
Sbjct: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ--LKTSMQSVLQ 5277
Query: 1007 QWK---DLQGEAPYHLLHLKIDVEKNR-FLASVEECRTELDRETKLMPQ----EGSEKII 1058
+WK L E + +E ++ + S+E R +++ L + EGS + +
Sbjct: 5278 EWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL 5337
Query: 1059 KEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRK 1118
+E V KG LC ++IEE C H ++ AI +K
Sbjct: 5338 QE--VIGKLKG---LCPSVAEIIEEKC-------------QNTHKRWTQVNQAIADQLQK 5379
Query: 1119 LMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV----KRAVEEIRNGV 1174
WK Y++ E ++ + E + + + ++ N E+ + ++E+++ V
Sbjct: 5380 AQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDV 5439
Query: 1175 TKRGETL---SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1231
K E S + RL E S+ L + + K L+ +E E +LS F
Sbjct: 5440 QKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
Query: 1232 GD----CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISA 1287
D K ++ + E L ++ +E + L+ AQ + H + +
Sbjct: 5500 KDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-LKL 5558
Query: 1288 KKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ----ERRIQVTLRKWE 1343
DV + Q + + +T LER E Q + KW
Sbjct: 5559 PLSDVAVKTLQNMNRQW------------IRATATALERCSELQGIGLNEKFLYCCEKW- 5605
Query: 1344 RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEA 1403
Q E L SL LEQ K + ++AE + +
Sbjct: 5606 -------------IQLLEKIEEALKVDVANSLPELLEQQKTYK------MLEAEVSINQT 5646
Query: 1404 SEIPLGPQNKQLLQ----QQAKSIKEQVKKLEDTLEEDIKTMEMVK-------TKWDHFG 1452
Q+ QLL + + KL D + ++ + K +W F
Sbjct: 5647 IADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT 5706
Query: 1453 SNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQ 1512
++ E L ++T+ L+A++ + Q + I E+++K + + + A
Sbjct: 5707 TSVENLFRFLTDTSHLLSAVKGQER---FSLYQTRSLIHELKNK---EIHFQRRRTTCAL 5760
Query: 1513 FVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVS 1569
+ GE + L + R +L++ + +E + + Q Q E + ++ +
Sbjct: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
Query: 1570 EFEDKLAVPIKICSS--ATETYKVLQEHMDLCQALE--------SLSSAITAFSASARKV 1619
E + +L V +K S E ++ L +L + LE +L T + R V
Sbjct: 5821 ELKSRLQV-LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHV 5879
Query: 1620 VNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAK 1677
+ D V ++ L +Q+ED+ R R+ +E+ L W ++ WL + E K
Sbjct: 5880 LVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK 5939
Query: 1678 ASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYS----KLLQLKESLFSVASKDDVK 1733
DIS + ++I+ LQ + + + + +S +L Q+ + L ++K
Sbjct: 5940 VLQ-TADISIE--------EMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA 5990
Query: 1734 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1793
+ L ++++RW+ L +I R+ L+ A QQ D+ + + W+ SEL
Sbjct: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050
Query: 1794 ISIMDHQVALTRHKDHAAEVESKKGELQSLQ----GHLAKLGSLGRAEDLHLLQGKA--- 1846
+ D Q E++ + E Q LQ H A + S+ D+ L A
Sbjct: 6051 YDVCDDQ-----------EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACAN 6099
Query: 1847 EDCFQLFEEASQVVERRQLALSHLA---------------EFLQSHASLSGILRQLRQTV 1891
E ++ ++ ++RR + ++ +FL ++ L+ +T
Sbjct: 6100 ETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTA 6159
Query: 1892 EATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAT 1951
NS S+++ + L+ +A + L + + E RT +
Sbjct: 6160 ACPNS-----SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
Query: 1952 ADQLCGE-VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDI-----EERTDKER 2005
Q+ E +R NL Q A+ + F +Q+EE + E I E
Sbjct: 6215 LKQMVHEGNQRWDNL----QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTN 6270
Query: 2006 LKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
++ + ++R N + E+ + +++ L +Q+ QK
Sbjct: 6271 VEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
Score = 90.9 bits (224), Expect = 5e-17
Identities = 420/2300 (18%), Positives = 883/2300 (38%), Gaps = 390/2300 (16%)
Query: 6582 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 6637
NQN+ ++E+ ++ TGQ K+A D + ++ E E + +LD+
Sbjct: 713 NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
Query: 6638 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 6694
+T + + + K + F ELMA++ +L+ + +++L T
Sbjct: 762 ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
Query: 6695 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 6754
+ + Q+ VV+ L + + D +D + + L Y + Q+L +
Sbjct: 815 KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
Query: 6755 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 6809
S +L S+ + +SNT ++K L +E + + T + +S D+
Sbjct: 873 ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
Query: 6810 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 6869
+S L + QQ + + E + D++ L+ K+++ + L +
Sbjct: 925 KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
Query: 6870 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6929
++ T L E S+ L + E L +L ++LPS+ + EV L+++
Sbjct: 968 RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
Query: 6930 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6989
QK E +K + IH LQ G N +T + +S
Sbjct: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
Query: 6990 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 7035
T+ A + +L+ L E I + LLE + Y +NN +
Sbjct: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
Query: 7036 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 7095
+ F ++E R + +Q L D Q +++ A+ KE E I + + K+
Sbjct: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
Query: 7096 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7154
TL+E + L+ + L+ L+ VL K + S L + ++
Sbjct: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
Query: 7155 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7214
F L+ +A ++ +L+N+QD + KQ + N +LKE HP + N +
Sbjct: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
Query: 7215 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7274
+ ++ + + + KAL +D+ + E T+ +A++ +
Sbjct: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
Query: 7275 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 7331
A + T + L+K D + ++ + ++ D S + + + + LS+
Sbjct: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
Query: 7332 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 7384
H +++ ++ L+A + K+++ +++ I + + +DP+
Sbjct: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
Query: 7385 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7444
L + + ++E + + MA L + G +N ++ + L + + ++
Sbjct: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
Query: 7445 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 7501
E+ ++ L Q+Q F ++ + L+Q E+ + + + +Y ++L ++ E+ +
Sbjct: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
Query: 7502 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7558
E ++ ++ + + Q L + + + F + ++ ++W + + + +
Sbjct: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
Query: 7559 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7618
+ W + + + +W + + L Q T D + KE++ + +Q
Sbjct: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
Query: 7619 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 7672
+ + + L S LQ + I K + L + A L
Sbjct: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
Query: 7673 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 7728
+D ++ + I + L+ S + EE+ + ++ K LEN +G T +L
Sbjct: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
Query: 7729 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7788
++L +++S + N + +LQ + +L + + N+W FS
Sbjct: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
Query: 7789 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 7843
L E E+K S +E+ ++KL E + +KI+ L+ + + L
Sbjct: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
Query: 7844 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7900
KA + S + E++L K+ + AR K+L+++L + +L + +LR W
Sbjct: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
Query: 7901 LAHIE------------------------------------------SELAKPIVYDSCN 7918
L + E +E + I+ +C
Sbjct: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
Query: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7978
+ Q L + E++ + + T S +L ++H + + L+
Sbjct: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
Query: 7979 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 8027
R + I + E +IE + L QK L D S W + + + S
Sbjct: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
Query: 8028 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 8070
G Y +KE ELKK + A Q + E QL++ K ++
Sbjct: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
Query: 8071 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
D LK++ +GN + W ++ S+L++L+ + +
Sbjct: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
Query: 8118 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 8168
DS V +T+++ L N E S D V+ K+++L+ + +SL +++I+A
Sbjct: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
Query: 8169 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 8211
+ + + + + II++++ L+ C + +R +K
Sbjct: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
Query: 8212 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 8268
+ LP E SD + ++SAA+ L W + + DS + S LSL+ + +++
Sbjct: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
Query: 8269 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 8317
R + + PLE D L LE+ + P E E + +
Sbjct: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
Query: 8318 LRGAVGLSGDH-SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 8376
+ +G S H L + L K + ++ + + + + L T +
Sbjct: 2490 VLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG 2549
Query: 8377 LGECSSSIDSVKRLEHKLKEEEESLPGF------VNLHST-------ETQTAGVIDRWEL 8423
+ + +D +K+ +++E++SL ++ H T E+Q + WE
Sbjct: 2550 PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQ 2609
Query: 8424 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 8483
++ Q K Q + ++ +F + +N + DTE L+Q Q+ LQ+
Sbjct: 2610 VEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ----------HLQL- 2651
Query: 8484 KLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKESRDLQDRLSQMNG 8529
+LK ++ ++ I L+ +L + + QA+ KE ++L+D ++ +
Sbjct: 2652 RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKK 2711
Query: 8530 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ 8589
+W+ LE ++ + +C ++M +L +N+ N +P+ L +IL
Sbjct: 2712 QWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSIPL---LPDDILS 2763
Query: 8590 DHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKEKVHVIGNRLKLL 8645
K ++ H+ +L Q V SL + L EG+D E + N+ ++L
Sbjct: 2764 QIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLR---NQYQML 2818
Query: 8646 LKEVSRHIKELEKLLDVSSS 8665
+ + ++ ++LE L+ S+
Sbjct: 2819 VLKSTQRSQQLEFKLEERSN 2838
Score = 79.3 bits (194), Expect = 2e-13
Identities = 565/3062 (18%), Positives = 1152/3062 (37%), Gaps = 460/3062 (15%)
Query: 5160 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5219
V L E +Q K G K + +T VA+D EK++ V+ W
Sbjct: 706 VELPENYNQNIKAGEKHEKEN---------EEFTGQLKVAKDVEKLIGQ-VEIWEAEAKS 755
Query: 5220 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ---QQSALGMLRQQTL 5276
V ++ +++ L A+ + EL+ E D ++++ Q+S +L
Sbjct: 756 VLDQDDVDTSMEESLKHLIAKGSMFDELMARSE--DMLQMDIQNISSQESFQHVLTTGLQ 813
Query: 5277 SMLQDGAAPTPGEEPPLMQEITAMQDRC--LNMQEKVKTNGKLVKQELKDREMVETQINS 5334
+ +Q+ L+ + + D L+++ K++ + K ++ + + + Q S
Sbjct: 814 AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRES 873
Query: 5335 VKCWVQETKEYLG-NPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5393
+ + KE L + T + L+ ++ L T ++I+ EE+ + L
Sbjct: 874 PGELISKHKEALIISNTKSLAKYLKAVEELKNNVT---EDIKMSLEEKSRDVCAKWESLH 930
Query: 5394 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5453
ELSL + ++ +D++ + ++ D I ++E+ ++L R+ + K L ++
Sbjct: 931 HELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGR--TKGLIKEHEACFSEEG 987
Query: 5454 NVVQAKTDQKVLG---EELDGCNSK------LMELDAAVQKFLEQNGQLGKPLAKKIGKL 5504
+ Q +VL EEL S+ L + + +++ L+ ++ L G
Sbjct: 988 CLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG- 1046
Query: 5505 TELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLRE 5564
T ++ TI +ENR + A + N+ EKA T+ ++ AS LR
Sbjct: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDNQ------PSTEKA---MEPTMKFSLASVLRP 1097
Query: 5565 QYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIK 5621
+ ++++E K+ + + ++ E+ + + + ++ E + ++
Sbjct: 1098 --LQEESIME--KDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQ 1153
Query: 5622 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV--GRLSLKEQLSHRQHLL-SE 5678
+L +LQ + E + + LE + P V R +LKE+ Q L +
Sbjct: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213
Query: 5679 MESLKPKVQAV--------QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ- 5729
MESL+ ++ V LC S L + + + L A R+ + +Q + +Q
Sbjct: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDAD-RIYQHLRNIQDSIAKQI 1272
Query: 5730 --CN-------------------IMQAAVVQYEQYEQEMKHLQQLIEGAHREIED----- 5763
CN MQ +++Y+ + M H Q E + +ED
Sbjct: 1273 EICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASL 1332
Query: 5764 --KPVATSNIQELQAQISR-HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5820
++ + +L A ++ +E +K + +I + K K L K M E
Sbjct: 1333 RTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
Query: 5821 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE-----EGTNSEISS 5875
LD + H V + LL ++ E + S+IS
Sbjct: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452
Query: 5876 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEFYEPGLEPSAT 5934
+ P T +V L + + K H A S ++ G E +
Sbjct: 1453 -IGLKDP-----TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
Query: 5935 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSESPEP 5992
+ + WE K +++E LE ++YQ+ ++T ++ E + L S
Sbjct: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
Query: 5993 GRSPESQMAEHQALMDEI---LMLQDEINELQSSLAEEL-VSESCEADPAEQ-------- 6040
+ + ++AE + + +E L + D+IN++ +L L ++ E P E+
Sbjct: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
Query: 6041 ------------------LALQSTLTVLAERMSTIRMKASGKRQL--LEEKLNDQLEEQR 6080
LAL L L + KA K +L L E+ ++L+E+
Sbjct: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
Query: 6081 Q--EQALQRYRCEADELDSWLLSTKATLD---------TALSPPKEPMDMEAQLMDCQNM 6129
Q EQ + E+ L S++ L+ + ++ + E+
Sbjct: 1687 QVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGS 1746
Query: 6130 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRA--LHDKQ 6187
E+ + + E+LL KA + ++ ++ KL ++ +L+ + + L + Q
Sbjct: 1747 TAELREDLDQAKTQIGMTESLL---KALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQ 1803
Query: 6188 LNM----QGTAQEKEESDVDLTATQSPGVQ---------------EWLAQARTTWTQQRQ 6228
+ +++ ES DL T+ +Q +W + + + +
Sbjct: 1804 IGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFE 1863
Query: 6229 SSLQQQKELEQEL----------------AEQKSLLRSVASR--------------GEEI 6258
SS + +K +EQ+L + S+L+ V G+E
Sbjct: 1864 SS-ETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEF 1922
Query: 6259 LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE---DQMRMKWESLHQEFSTKQKLLQN 6315
++ + A E D L Q L ++ + + KW+ + +E K +L
Sbjct: 1923 ELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM-EEPGEKTELFCQ 1981
Query: 6316 VLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ 6375
L +++EQ + +L + + Y + T L+D ++S K
Sbjct: 1982 ALARKREQ--FESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLL 2039
Query: 6376 SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMD- 6434
+Q D W+ +++E L V L E + L + K+I + E D
Sbjct: 2040 PTE-DQSFNDLAHDVIHWIKEIKESLMV---LNSSEGKMPLEERIQKIKEIILLKPEGDA 2095
Query: 6435 KNKNLFSQAFPENGDNRDVIEDTLGCLLGRL-SLLDSVVNQRCHQMKERL--QQILNFQN 6491
+ + + QA +++ TL + + + L HQ K L ++ L +
Sbjct: 2096 RIETIMKQA---ESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKE 2152
Query: 6492 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6551
DL+++ L + + E+ Q++ ++ ++ + + ELK +G+ L
Sbjct: 2153 DLRLMLIELKKKQEAGFALQHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLL 2210
Query: 6552 --VEQPSMQE--LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6607
+ PS E +++ +++ L+ + L+ ++ Y+ + DL L+ +
Sbjct: 2211 ECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSK 2270
Query: 6608 KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFA--VQKETQFHTE 6665
+ + S K Q +++ + Q LE+ + L + +KI++ A V++ T +
Sbjct: 2271 EF-----VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQ 2325
Query: 6666 LMAQASAVLKRAHKRGVE-------------LEYILETWSHLDE------DQQELSRQLE 6706
+ + + ++ +E L IL++ ++ +E +
Sbjct: 2326 KIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSD 2385
Query: 6707 VVESSIPSVGLVEENEDRLIDR---ITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 6763
V ES+ S + + ED I++ + + + SLN Q + D+ K +
Sbjct: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNA-QESMKNTEDERKVNELQNQPL 2444
Query: 6764 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ----SESADLI-HWLQSAKDRL 6818
+L++ L L K+ +L + +K + + +E+ L+ H + + L
Sbjct: 2445 ELDTMLRNE---QLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHL 2501
Query: 6819 EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6878
+ Q +T+ + E L F E+ V +SS+K+ L T + L++ +D+ T
Sbjct: 2502 DNLLQALITLKKNKESQYCVLRDFQEYLAAV--ESSMKA--LLTDKESLKVGPLDSVTYL 2557
Query: 6879 SELSRIDS---QWTDLLTNIPAVQEKL--HQLQMDKLPSRHAISEVMSWISLMENVIQKD 6933
++ + + + D L N+ E L H MDK I ++ +E IQK
Sbjct: 2558 DKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKK 2617
Query: 6934 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 6993
+ + Y + K + +I + +Q + L++ S + +
Sbjct: 2618 YS--QQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ------LRLKSPEERAGNQSMIALT 2669
Query: 6994 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK-RLKQQHRIG 7052
L A + +L+G +++ + G E E+ + LK +ET E L+ +++I
Sbjct: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK-KNLEDGINNLKKQWETLEPLHLEAENQI- 2727
Query: 7053 DQASVQNALKD-----------------------------CQDLEDLIKAKEKEVEKIEQ 7083
+ ++N +K+ C+ D I A+++ VE + +
Sbjct: 2728 KKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAE 2787
Query: 7084 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 7143
+ + S + +TL +L + L Q L+ L++ S+ K
Sbjct: 2788 EVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
Query: 7144 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 7203
+ E+ +L R+ T + EA L++ LE ++ LQ+ S + L+E
Sbjct: 2848 LMVQESE-TLIIPRVETAATEA------ELKHHHVTLEASQKELQEIDSGISTHLQE--- 2897
Query: 7204 PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY--------KDYSKQC---- 7251
LTN +E+N+ LE +QL++ K QR+ + K C
Sbjct: 2898 -----LTNIYEELNVFERLFLE---DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFH 2949
Query: 7252 --ASTVQQQED---RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHEL 7306
S +Q++ D R LL NK + ++ I + D L + + L ++
Sbjct: 2950 EKTSALQEEADSIQRNELLLNQEVNKGVKEE-----IYNLKDRLTAIKCCILQVLKLKKV 3004
Query: 7307 GEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEA 7366
+ + D S +Q+ + L + KQ + + Y+ + A++
Sbjct: 3005 FDYIGLNWDFSQLDQLQTQVFEKEKEL----EEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060
Query: 7367 WIVE-AEEILQGQDPSHSS---DLSTIQERMEELK---GQMLKFSSMAPDLD------RL 7413
I + E +L+ D S S + + +R+E+ K +++K + D +
Sbjct: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120
Query: 7414 NELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7473
++ NDK K +QN+ +L L + +K ET + L
Sbjct: 3121 LQIKLNAEENDKLYKVLQNM--------------VLELSPKELDEKNCQDKLETSLHVLN 3166
Query: 7474 QTEQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSI-IIDGQRLLEQGQVDDR 7530
Q + +L + N + H+ ++ E FQ ++++ + ++ I+ QR + D
Sbjct: 3167 QIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASD- 3225
Query: 7531 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 7590
KL + + R +++ RY+E + + ++ L
Sbjct: 3226 --VETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTR--------AVESITSL 3275
Query: 7591 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL--LSADSGAEAALQ---- 7644
++ IP R + ++ LR+Q TV + L L S EA LQ
Sbjct: 3276 EAIIIPY---RVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYT 3332
Query: 7645 -AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDH 7703
EL K A E + ++ K + K E+ I +L K+ T + SLP
Sbjct: 3333 LQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLS 3392
Query: 7704 HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEE 7763
+ E + K L + + S ++L +L + L + +D L + V L +W
Sbjct: 3393 YREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLS 3452
Query: 7764 LCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQ 7823
L E EW ++ E+ K+ EW + S+ + I+++ + E+L
Sbjct: 3453 LL-----------EAAKEWEMWCEELKQ--EW--KFVSEEIEREAIILDNLQEEL----- 3492
Query: 7824 EEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK-- 7881
EI+ +E A S+ + + G+ ++ Q LL L+ R++ ++
Sbjct: 3493 PEISKTKE-----------AATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNV 3541
Query: 7882 -------ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR 7934
ET+ A Q++ L ++ N E +Q ++ E+ +
Sbjct: 3542 PESSGAVETVPAFQEITSMKERCNKLLQKVQK-----------NKELVQTEIQERHSFTK 3590
Query: 7935 DI 7936
+I
Sbjct: 3591 EI 3592
Score = 67.0 bits (162), Expect = 8e-10
Identities = 316/1695 (18%), Positives = 635/1695 (37%), Gaps = 300/1695 (17%)
Query: 7065 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 7111
+ L+ L+K E + + N L + +++ E+ S V+S R+L + W
Sbjct: 311 EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
Query: 7112 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 7171
LDH + KI L L A+ + LM+ S S+ + ++ +Q ++
Sbjct: 371 DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
Query: 7172 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 7227
++L D E L +T + E H P+ N L+E+ R NN+LE+ +
Sbjct: 429 LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
Query: 7228 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 7283
E +L L K SK ++ + ELL +K I + E + T
Sbjct: 482 LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
Query: 7284 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
Q C ++ K L A I + + +C + +
Sbjct: 540 QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
Query: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
+++LQ + + T+ ++L L A E T +E ++E+ + L
Sbjct: 578 KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
Query: 7404 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 7457
++ + LNE G L ++ K ++ LN+ W + S+T + Q
Sbjct: 621 WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
Query: 7458 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 7513
Q + + + V+ ++VE+ NY ++ HE E + ++
Sbjct: 679 DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
Query: 7514 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7573
D ++L+ Q ++ W+ + + ++D Q M E
Sbjct: 738 ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
Query: 7574 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7633
L+ + + S +FDE+ + + L+ I + E+ + +L
Sbjct: 769 SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
Query: 7634 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7693
+ LQA++ E +EK + ++L K L + D + K + +S ++L ++
Sbjct: 810 T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
Query: 7694 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 7753
+ Q L ++ K E + S T L + + L ++ D L E+
Sbjct: 862 MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
Query: 7754 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 7813
+ +WE L H+LSL QQ+ + EK K L + + ++E ++++ ++
Sbjct: 919 SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
Query: 7814 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7872
+ L K++ E ++E + QL E L + E + + + ++ ++ ++ ++
Sbjct: 971 RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
Query: 7873 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7932
+ +K E + +Q S + E+ P +SE K + Q
Sbjct: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
Query: 7933 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 7990
++ +E +ASVL L E + + D A SI D +R+I +E
Sbjct: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
Query: 7991 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 8050
L+ + + D+S ED +SS A + VI K+FE ++
Sbjct: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
Query: 8051 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 8110
+ I K + R+ + L+ + N R ++L+ + +L
Sbjct: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
Query: 8111 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 8170
+ S+L+ +++ L I+ F D + L+ Q I+ ++ G
Sbjct: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
Query: 8171 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8230
++++ P D ++ + + + + + RV+R L
Sbjct: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
Query: 8231 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER-SGRDTPASVDSIPLEWDHDY 8289
AL D R+A LS +P ++LS S Q + + ++ + + + H
Sbjct: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD 1378
Query: 8290 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS-ALESQIRQLGKALDDSRFQ 8348
+ L+ + A +D ++ D + ++ LS H ++ + + K L+ F+
Sbjct: 1379 KCLKMLDMSFKDAERGDDTSCENLLDAF---SIKLSETHGYGVQEEFTEENKLLEACIFK 1435
Query: 8349 ----------IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 8398
+Q + I K PT P + K ++L +D + + L+E
Sbjct: 1436 NNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRL----DKVLDEYEEEKRHLQEMA 1491
Query: 8399 ESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELRMKQNLQKWQQFNSDLNSIW 8453
SLP F + + Q + WE L + L + R+ + L+++Q F S L +
Sbjct: 1492 NSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTT-- 1549
Query: 8454 AWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC--- 8505
L EE + LQ + L I IE+ ++ E + VD + ++
Sbjct: 1550 --LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607
Query: 8506 -----SPEFTQAD----------SKESRDLQDRLSQMNGRWDRVCSL---LEEWRGLLQD 8547
P F + ++++ D + L + WD++ +L ++EW +
Sbjct: 1608 MKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW----TE 1663
Query: 8548 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQL 8607
+Q H+++ E+ +R K E+ + + + +++ +I+ L S++
Sbjct: 1664 KALQKMELHQLTE------EDRERLKEEL-----QVHEQKTSEFSRRVAEIQFLLQSSEI 1712
Query: 8608 RVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKLLLKEVSRHIKELEKLLDVS 8663
+ LQ M +L E CL + H + L+ L + I E LL
Sbjct: 1713 PL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKAL 1771
Query: 8664 SSQQDLSSWSSADEL 8678
S L ++ +E+
Sbjct: 1772 SPSDSLEIFTKLEEI 1786
Score = 57.8 bits (138), Expect = 5e-07
Identities = 88/534 (16%), Positives = 217/534 (40%), Gaps = 51/534 (9%)
Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
+ + GE+ L +++ + + + ++ L++ W D+ +S + W+ ++
Sbjct: 5760 LTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKI 5819
Query: 2743 NQLEQWMESVDQKIEHPL-QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY 2801
+L+ ++ + + E PL + L + L+ L+ L+ + + L + A +
Sbjct: 5820 KELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTR-H 5878
Query: 2802 EKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKE 2861
ED E L Q+ D+ + +++E+ + +++ + E WL +
Sbjct: 5879 VLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMEN 5938
Query: 2862 ELHRWSDMSGDSSATQKKLSKI-KELIDSREIGASRLSRVESLAPEVKQNTTASGCELMH 2920
++ + +D+S ++ + K+ K+ ++ + + +++ + ++ + + S +
Sbjct: 5939 KVLQTADIS-----IEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEID 5993
Query: 2921 TEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWA 2980
++ + W+ D + S ++ L A +Q L++ + L+TW
Sbjct: 5994 DKLNKINDRWQHLFDVI---GSRVKKLKETFAFIQQ------------LDKNMSNLRTWL 6038
Query: 2981 QQLTLLEGKNT------DEEIVECWHKGQEILDALQKAEPRTE------DLKSQLNELCR 3028
++ K D+EI + + Q++ +++ E D+ ++ C
Sbjct: 6039 ARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACA 6098
Query: 3029 FSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQI--LQQRFRKAFRDFQQWLVNAKIT 3086
+ + L + + +C + + E+ L Q+F + F+ WL +A+
Sbjct: 6099 NETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAE-R 6157
Query: 3087 TAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTK-------EK 3139
TA C N SEV + K E L E Q +++ L++ EL++ + +
Sbjct: 6158 TAAC----PNSSEVLYTSAK--EELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDT 6211
Query: 3140 AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTE 3193
A ++ V + W N + L + Q ++FE + E I WL++ +
Sbjct: 6212 ASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
Score = 41.2 bits (95), Expect = 0.046
Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)
Query: 8421 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8480
W LQ + L K L+ +N ++++NS L+ + ++ EE+ L L + D+ ++
Sbjct: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
Query: 8481 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 8536
+L+E +DH+ A + +N P T+A +E +L D + + +
Sbjct: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
Query: 8537 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8596
L++E L + + + E +LL EN D +VP
Sbjct: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
Query: 8597 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 8644
++L E + R+ ++ + LL+ CL E K K+ + G+R ++L
Sbjct: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
Query: 8645 LLKEVSRHIKELEKLLDVSSSQQ 8667
LL++ + I+E E L + +S Q
Sbjct: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
Score = 39.3 bits (90), Expect = 0.17
Identities = 89/494 (18%), Positives = 194/494 (39%), Gaps = 55/494 (11%)
Query: 316 DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRK-QIEHLIQPLHR 374
++ + KE++ + + ++L Q ++++L +H V+ M K QIEHL HR
Sbjct: 5847 EKELIKELEQSLASWTQNLKELQTMKADLT------RHVLVEDVMVLKEQIEHL----HR 5896
Query: 375 DGK-LSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAE--VALREEITV 431
+ L L A+ KQ + RL W + +K+ + AWL + E V +I++
Sbjct: 5897 QWEDLCLRVAIRKQE---IEDRLNTWVVFNEKNKE-----LCAWLVQMENKVLQTADISI 5948
Query: 432 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 491
+++ E+ ++ + N K+ ++ + + + D+L + +R+
Sbjct: 5949 EEMIEKLQKDCMEEINLFSE---NKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005
Query: 492 VSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---------EQLLQN 542
+ + K L+ + + L S L++W+ + S +++ +
Sbjct: 6006 LFDVIGSRVKK---LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKR 6062
Query: 543 YVSFIENSKFFEQYEVTYQILKQTAEMYVK---ADGSVEEAENVMKFMNETTAQWRNLSV 599
+ + EQ+ + + ++ + A + E +++ + +WRN+
Sbjct: 6063 LAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122
Query: 600 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML---NQSE----NAKKD------F 646
R +EE W ++ + + + WL+ AE+ N SE +AK++ F
Sbjct: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182
Query: 647 FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ-YAQADE 705
R + + Q +N L + LKQ + N RW L V +
Sbjct: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
Query: 706 MDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY-K 764
++E+ ++ + TE +L+ S + ++ L +Q + + + +
Sbjct: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
Query: 765 IITKTAHLITKESP 778
+I LI K P
Sbjct: 6303 LIVFGEQLIQKSEP 6316
Score = 35.4 bits (80), Expect = 2.5
Identities = 26/121 (21%), Positives = 55/121 (45%), Gaps = 6/121 (4%)
Query: 1444 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1498
+K S+ ++ W+ + E EL L+ + D+Q +++V +QEI ++ +
Sbjct: 6572 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 6631
Query: 1499 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFE 1558
+V + ++ F Q + ES ++++L Q+ E + G + L Q Q F
Sbjct: 6632 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFH 6690
Query: 1559 E 1559
+
Sbjct: 6691 Q 6691
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
[Homo sapiens]
Length = 6885
Score = 2049 bits (5308), Expect = 0.0
Identities = 1743/6321 (27%), Positives = 2982/6321 (47%), Gaps = 546/6321 (8%)
Query: 2749 MESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--LYEKTED 2806
+ V ++ L+ + KE + Q +L + E LI+K +E + T+
Sbjct: 837 LTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGE----LISKHKEALIISNTKS 892
Query: 2807 ESFKDTAQEELKTQFN-DIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHR 2865
+ A EELK DI +EK R V K ++ HE + ++ K ++ +
Sbjct: 893 LAKYLKAVEELKNNVTEDIKMSLEEKSRDV--CAKWESLH----HELSLYVQQLKIDIEK 946
Query: 2866 WSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC--ELMHTEM 2923
+S + +K+++K K+LI R R + L E + + GC +L H M
Sbjct: 947 -GKLSDNILKLEKQINKEKKLI--------RRGRTKGLIKEHEACFSEEGCLYQLNH-HM 996
Query: 2924 QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQL 2983
+ LR ++ ++Q ++ L+ + +++ L+ + +
Sbjct: 997 EVLRELCEELPSQ--KSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTI 1054
Query: 2984 TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTE-DLKSQLNELCRFSRDLSTYSGKVSG 3042
T E + D + K + EP + L S L L S YS ++
Sbjct: 1055 TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINS 1114
Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
L++ Y+ QN + + F D + AK+T + + +N ++
Sbjct: 1115 LLERYDTYRDILEHHLQNNKFRITSDFSSE-EDRSSSCLQAKLTDLQ---VIKNETDARW 1170
Query: 3103 SLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH 3162
+I E+ K ++ + + L KE+ + +Q + E + +
Sbjct: 1171 KEFEIISLKLENHVNDIKKPFVIKERDTL-----KERERELQMTLNTRMESLETALRLVL 1225
Query: 3163 QKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRRE-----QQKLQ 3217
E A +L + D + IQ + +++ + D AK+ E ++
Sbjct: 1226 PVEKA--SLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGN 1283
Query: 3218 SVLEEIHCYEPQLNR---LKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN-------- 3266
VL+E+H ++ + LK K Q +EG HRV + AL +
Sbjct: 1284 FVLKELHPFDLHAMQNIILKYKTQ--FEGM------NHRVQRSEDTLKALEDFLASLRTA 1335
Query: 3267 -LTKEKVSRL---DRIVAEHNQFSLGIKELQ-DWMTDAIHMLDSYCH------------- 3308
L+ E V+ L D VA+ N ++ KE + M D LD
Sbjct: 1336 KLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGD 1395
Query: 3309 PTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSV-- 3366
TS +++LD+ ++KL ++E + + N + I +Q Q+ +
Sbjct: 1396 DTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGL 1455
Query: 3367 KDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG----WMDSMEANLNESERQHAEL 3422
KD + + +L+ L ++ + +++ + + D E +N+ + L
Sbjct: 1456 KDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVL 1515
Query: 3423 RDKTTML--------GKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYR 3474
+ T L G+ L ++ ++ S+L T+ K + + + ++L++R
Sbjct: 1516 WENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIA 1575
Query: 3475 AIQ------ERAKEAVTKSEKLVRLHQEYQRDLKAFEV-------------WLGQEQEKL 3515
I+ E V K ++ + Q Y +K FE WL ++
Sbjct: 1576 EIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTE 1635
Query: 3516 DQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESL 3575
D Y L G A L +L+ + E +AL LH + EDR E L
Sbjct: 1636 DYYENL-GRALALWDKLFNLKNVIDEWTE-KALQKMELHQLTE---------EDR--ERL 1682
Query: 3576 RQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKE 3635
+++ Q ++ + SE F+ V +++ + Q ++ L+ E + + T E
Sbjct: 1683 KEELQVHEQKTSE----FSRRVAEIQFLLQS-SEIPLELQVMESSILNKMEHVQKCLTGE 1737
Query: 3636 IQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLE 3695
H + E+ R+++++ A+ Q + ES + + + ++ ++ + + Q+L+
Sbjct: 1738 SNCHALSGSTAEL---REDLDQ--AKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQ 1792
Query: 3696 ----------QIKFLEEEIQSLEESESSLS-----------------------SYSDWYG 3722
QI L E+ L++ S+S +++DW+
Sbjct: 1793 QKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFS 1852
Query: 3723 STHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE 3782
+ N K + +V +KL+ L L +E +S +K + K+L +
Sbjct: 1853 NIKVNLKECFESSETKKSVE--QKLQKLSDFLT-LEGRNSKIKQVDSVLKHVKKHLPKAH 1909
Query: 3783 AERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3842
+ L + +L+++ S + LE L D + L +W+ +E
Sbjct: 1910 VKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969
Query: 3843 EEP--KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ 3900
EEP K EL+ + L++ + ++V S+K E E++ + T +D+ Q
Sbjct: 1970 EEPGEKTELFCQA--LARKREQFESVAQLNNSLKEYGFTEEE--EIIMEATCL--MDRYQ 2023
Query: 3901 SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT 3960
+ + L I +E + + + +N +V W+ ++ L+ + E
Sbjct: 2024 TLLRQLSEIEEED----KLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEG------- 2072
Query: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC---ADHLQAKLKQNVHAHLQGTKDSY 4017
K +EE + L+ +GD I A+ +A L Q + D+
Sbjct: 2073 ------KMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNT 2126
Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVK 4077
+ ST + L E +K++ ++ L+ L Q + + Q L +A Q+K
Sbjct: 2127 LHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQ-EAGFALQHGLQEKKA--QLK 2183
Query: 4078 HFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKH 4137
++ ++A+ LL + N ++ T E W EIKH
Sbjct: 2184 IYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEP---------------WLEIKH 2228
Query: 4138 LKSELWIYLQDADQQLQNMKRRHSELEL----------NIAQNMVS---------QVKDF 4178
L L LQD+ Q L R H ++ N ++ VS V++
Sbjct: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEK 2288
Query: 4179 VKKLQS-------KQASVNTIIEKVNKLTKKEESPEHK----EINHLNDQWLDL------ 4221
++KLQ + ++ I+ + + S K +I L + DL
Sbjct: 2289 LQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLAS 2348
Query: 4222 CRQSNNLCLQREEDLQRT-----------RDYHDCMNVVE-----VFLEKFTTEWDNLAR 4265
+Q CL +R+ R+ +V E +EK +W+
Sbjct: 2349 AKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEI--- 2405
Query: 4266 SDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW 4325
+ +AV + K+L+L QE ED + + + L LD L EQ +E+ +
Sbjct: 2406 --NKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTM-LRNEQLEEIEKLY 2462
Query: 4326 FQLEDLIKRKIQVSVTNLEELNVVQSRFQEL--MEWAEEQQPNIAEALKQSPPPDMAQNL 4383
QLE K+ + E LN ++ L + ++ + N+ +AL +Q
Sbjct: 2463 TQLE--AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
Query: 4384 LMDHLAICSELEAKQMLLKSLIKDADRVMADL--GLNERQVIQKALSDAQSHVNCLSDLV 4441
++ L A + +K+L+ D + + + I+K ++ + + L +L
Sbjct: 2521 VLRDFQ--EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLK 2578
Query: 4442 GQRRKYLNKALSEKTQFLMAVFQATS----QIQQHERKIMFREHICLLPDDVSKQVKTCK 4497
+ N + L + + Q++Q +K ++ + D+ + + +
Sbjct: 2579 IKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEY--DEFTTLMNKVQ 2636
Query: 4498 SAQASLKTYQNEV--------------------TGLWA--QGRELMKEVTEQEKSEVLGK 4535
+ SL+ Q + T L A G ++K E + + G+
Sbjct: 2637 DTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGE 2696
Query: 4536 LQELQSVYDSV--LQKCSHRLQELE---KNLVSRKHFKEDFDKACHWLKQADIVTFPEIN 4590
+E +++ D + L+K L+ L +N + + + + W K P I
Sbjct: 2697 -KEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIP 2755
Query: 4591 LMNES--SELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNAL 4648
L+ + S++ + IL + E+L ++ +PSL + S L+ L L
Sbjct: 2756 LLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDK----VPSLTTYEGSDLNNTLEDL 2811
Query: 4649 PRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFL-RMSKVPTDLAVE 4707
Q+ ++V + + +++ + R + ++I + E E + R+ T+ ++
Sbjct: 2812 RNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELK 2871
Query: 4708 EALSLQDGCRAILDEV-AGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQT 4766
+ + L E+ +G+ + EL E + + D++ +L +R++R
Sbjct: 2872 HHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQR-- 2929
Query: 4767 EQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE-ETLPAEEKLKMYHSLAGSL 4825
+++T + + K C+Q + +++EE + E L +E K +L
Sbjct: 2930 -----FIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNL 2984
Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
+D +K + + L D + Q+ Q ++ + E + + ++ +
Sbjct: 2985 KDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEE 3044
Query: 4886 SIDFQTEMS--RSLDWLRR------VKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4937
+Q +S R++D + +KA S P LN Q + + I K + +E+
Sbjct: 3045 HGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKK 3104
Query: 4938 LRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELS--ELDG-DIQEALRTRQAT 4987
L KEK +L + + L++ + ELS ELD + Q+ L T
Sbjct: 3105 LNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHV 3164
Query: 4988 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 5047
L +I SQ Q+ + E+ + + E+ +E + + M
Sbjct: 3165 LNQIKSQLQQPLLI----------NLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEK 3214
Query: 5048 NLEELHSLVATLDPLIKPTGKEDLEQKV-ASLELRSQRMSRDSGAQVDLLQRCTAQWHDY 5106
EE S + ++ ++ EDL+ ++ S++LR+ ++ D + T Y
Sbjct: 3215 QREENSSEASDVETKLREF--EDLQMQLNTSIDLRTNVLN-------DAYENLTR----Y 3261
Query: 5107 QKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKA 5166
++A +E + E + + + + E L + + L S V +++
Sbjct: 3262 KEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTV-------AHIQDLT 3314
Query: 5167 SQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEM 5226
+L + +K L ++ + + + ++ + QE E ++ + + +
Sbjct: 3315 EKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTN 3374
Query: 5227 IDQLQDKLPGS-SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAP 5285
+ +++ L S S+ S E L LE V L + L LRQ L +L+
Sbjct: 3375 LSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQ-ILRLLR--LRC 3431
Query: 5286 TPGEEPPLMQEITAMQDRCLNMQE----------KVKTNGKLVKQELKDREMVETQINSV 5335
T + L++ ++A+ ++ L++ E ++K K V +E++ ++ +
Sbjct: 3432 TENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEE 3491
Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK---MAEEQKEKYLGLYTIL 5392
+ +TKE A EEL LL + +N+EK + ++ + +
Sbjct: 3492 LPEISKTKEA---------ATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVP 3542
Query: 5393 PSELSLQLAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK 5451
S +++ ++ ++++ +++V+++K Q ++ K++ + +
Sbjct: 3543 ESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602
Query: 5452 TDNVVQ-AKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQ 5510
T + A D E+ + S L + + +E K K +E++
Sbjct: 3603 TTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIME----------KLRIKYSEMYTI 3652
Query: 5511 TIRQAENRLSKLNQAASHLEEY--NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYIL 5568
+ E+++ + +A ++E NE+L+ + + K+ N L+++
Sbjct: 3653 VPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKN 3712
Query: 5569 HQTLLEESKEIDSELEAMTEKLQYLTSVY--CTEKMSQQVAELG-------RETEELRQM 5619
+ E K++ EL+ KL L S E+ Q E ++ +++ Q
Sbjct: 3713 IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQR 3772
Query: 5620 IKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM 5679
+ R L A M+++ LK +A +E L +P LSH H +
Sbjct: 3773 AECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSH--HASTVQ 3828
Query: 5680 ESLKPKVQAVQLCQSALRIPED---VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAA 5736
+L+ Q L S ED + + L + L + + LQ ++ +Q
Sbjct: 3829 MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRM 3888
Query: 5737 VVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIA 5796
E E+K +++ + + K + + +E + E + + I+ ++ IA
Sbjct: 3889 ADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE---HLKHGEVILENIRPMKKTIA 3945
Query: 5797 SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL 5856
+ S L + L L + + L+ V+ T +
Sbjct: 3946 EIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEI 4005
Query: 5857 --LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS--AERLQTDAA 5912
L + + + +S A + P + Q ++ Q L+
Sbjct: 4006 ENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVL 4065
Query: 5913 KIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSL 5972
+H QE E P+ T++ G + + SE++ ++ ++ +
Sbjct: 4066 NLHQHLKQEQEGVERDRLPAVTSEEGGVA------ERDASERKLNRRGSMSYLAAVEEEV 4119
Query: 5973 QSISTKMEAIELKLSESPEPGRS---PESQMAEHQALMDEILMLQD---EINELQSSLAE 6026
+ S K + + K SP+ S + M E +A ++Q+ +I+ +S+A+
Sbjct: 4120 EESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQ 4179
Query: 6027 ELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL-LEEKLNDQLEEQRQE--Q 6083
L +S + + +L+ T E +T ++A + L ++E+ R E +
Sbjct: 4180 ILTPDSLNTEQGPECSLRPNQT---EEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
Query: 6084 ALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSEL 6143
L + + EL+ WL ++ +E QL+ CQ ML EIE KV L E
Sbjct: 4237 VLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLET 4296
Query: 6144 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6203
++ L T+ EAE L+ KL+ +K +L ++Q L +K Q K+ S+ +
Sbjct: 4297 C---KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPE 4353
Query: 6204 LTATQSPGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 6262
P L T Q RQ QQQ+ LE + EQK ++ + +++ Q+
Sbjct: 4354 HQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQY 4413
Query: 6263 SAAE--TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQE 6320
+ T+ ++ S E + S + Q KW+ LH E S+K KL L +
Sbjct: 4414 CQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEP 4473
Query: 6321 QEQVLYSRPNRLLSGVPLYKGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHL 6379
Q S +L V +Y PT ++ T+ L+ L Q + +Q + I+L
Sbjct: 4474 Q----VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINL 4529
Query: 6380 EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL 6439
++KL++ S L VEE L + L E+ + E LA ++K++ + K
Sbjct: 4530 DKKLFELFLTLSQCLSSVEEMLEMPR-LYREDGSGQQVHYETLALELKKLYLALSDKKGD 4588
Query: 6440 FSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 6499
+A G+N +++ + L L + R +K L ++QN++K L+
Sbjct: 4589 LLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQ 4648
Query: 6500 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 6559
L +K + Q L + Q VAEQ++ L+ ++ + +L+ G++L + +QE
Sbjct: 4649 LIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE 4708
Query: 6560 LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSS 6619
+ KL+D+ D + ++ +R + L+ +SQ + LQ + +L++ G+EK+A S
Sbjct: 4709 VYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKS 4768
Query: 6620 KEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 6679
K +Q ++ HK +FQ L + M+L + KI+ +Q F E + + + +++ +
Sbjct: 4769 KVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQ 4828
Query: 6680 RGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSL 6739
G++L+ +L+ W DE+ L + LE++ S++PSV LVEE E+RL++RI+ YQ +K ++
Sbjct: 4829 CGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
Query: 6740 NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR 6799
+LYQ L++GK+L+ S+SC +LE Q+ +L E WLS K+ ELHRL+ +LKH
Sbjct: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS 4948
Query: 6800 YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV 6859
Y +S L WL+S++ L +W +QS+ V Q+L+ +R ++N F EFSKEVD +SSLK++V
Sbjct: 4949 YNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAV 5008
Query: 6860 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEV 6919
+S GNQLL LK+ DTATLR+ L++ + +WT L+T +P +QEKLHQLQM+KLPSR AI+E+
Sbjct: 5009 ISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
Query: 6920 MSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISS 6979
+SW++ +E+ DED++ + + LQK+K F+++++ KQ VDFVNQS+LQ+S+
Sbjct: 5069 ISWMNNVEHQTS-DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLST 5127
Query: 6980 QDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFE 7039
DVESKR ++T+FAE LG MN+ W + G++ KIQ LE LLES +E EN +Q L W E
Sbjct: 5128 CDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLE 5187
Query: 7040 TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI 7099
QE+RLK + SVQ L DCQD+E+ + K K +++++Q+ L L ++ +
Sbjct: 5188 AQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL-ESGAVPLLED 5246
Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL 7159
S + EL Q +++ V QLK ++SVL +W + +D++N + Y + + +
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
Query: 7160 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 7219
SLE ++ QV+NLQ+LQD+ E E S +K + +L C P V E + + + R
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTHKR 5365
Query: 7220 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEV 7279
W + + IA+QLQ +++LLQLW+ Y + + A+ ++QQE + +L + + + + +
Sbjct: 5366 WTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL 5425
Query: 7280 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7339
+QD +L + K++ + ++L Q ++S + SL Q LE+
Sbjct: 5426 PPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-QRAAYLEKM 5484
Query: 7340 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQ 7399
L + + + ++ F LE+L+ I+ EE L D H + +E +
Sbjct: 5485 LLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---DRLHQQE----KENPDSFLNH 5537
Query: 7400 MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ 7459
+L ++ +PD++ LNE+ +LPL+D +K +QN+NR W ++ ER S+LQ L ++
Sbjct: 5538 VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGL-NE 5596
Query: 7460 TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQ 7519
FL CE W++ L + E+ L V+++ + LLEQQ+ +++ +AE+ Q I S +
Sbjct: 5597 KFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSL 5656
Query: 7520 RLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL 7579
+LL+ ++++R EF + + L+++WQ ++ +QR+G +D +RQWQ + E L ++L
Sbjct: 5657 QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFL 5716
Query: 7580 VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA 7639
+ S+L + G L Q R+L E++ KE F R++ + LT+EAG++LLL+ D
Sbjct: 5717 TDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKT 5776
Query: 7640 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7699
+ ++ ++++Q+ WK +L E K+ ++ W++CEK I + +L+ K +
Sbjct: 5777 KESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP 5836
Query: 7700 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
LP+ HE+LH E+ KELE ++ SWT +L +L +K L+ ++ +D+ +L E++E L R
Sbjct: 5837 LPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHR 5896
Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
QWE+LC ++++R+Q+I +RLN W VF+EKNKELC WL QME+KV Q DI IEEMIEKL+
Sbjct: 5897 QWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQ 5956
Query: 7820 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 7879
KD EEI + ENK+QL+QMG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKK
Sbjct: 5957 KDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKK 6016
Query: 7880 LKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKH 7939
LKET +QQLDKNMS+LRTWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+H
Sbjct: 6017 LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQH 6076
Query: 7940 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 7999
S GV SV N+C+VLLHD DACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWR
Sbjct: 6077 SAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWR 6136
Query: 8000 LWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELI 8059
LWQKFLDDYSRFEDWLKS+ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELI
Sbjct: 6137 LWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELI 6196
Query: 8060 NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 8119
NKQYRRLARENRTD+A LKQMVHEGNQRWDNLQ+RVT++LRRL+HF QREEFE R+S
Sbjct: 6197 NKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRES 6256
Query: 8120 ILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8179
ILVWLTEMDLQLTN+EHFSE D K++QL FQQEI+LN NKI+Q+I GEQLI+KSEP
Sbjct: 6257 ILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEP 6316
Query: 8180 LDAAIIEEELDELRRYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDL 8238
LDA +IE+EL+EL RYCQEVFGRV R+H++L P +DE + S+ E ++ED +
Sbjct: 6317 LDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTD 6376
Query: 8239 HWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESA 8298
W R S +PSS SL ERSG +TP SVDSIPLEWDH D+
Sbjct: 6377 SWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGS---- 6428
Query: 8299 MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRS 8358
S EE ++ + +S HS + + Q++ N+
Sbjct: 6429 ------SSHEEDEEGPYYSALSGKSISDGHS---WHVPDSPSCPEHHYKQMEGDRNV--- 6476
Query: 8359 KTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 8415
P P T YK G + L + + L ++E+ L G Q +
Sbjct: 6477 -PPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------QQS 6529
Query: 8416 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 8475
G DRWE++QAQ L +L++KQNL QQ NSD+++I WL TE ELE L+ + +DI
Sbjct: 6530 GAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKPPSDI 6586
Query: 8476 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8535
Q IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W+
Sbjct: 6587 QEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQ 6646
Query: 8536 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8595
++ WRG L+ +LMQCQ FH++S LLL L + R+ + D D L + ++L
Sbjct: 6647 GAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL 6706
Query: 8596 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8655
MQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI +LK L ++VS
Sbjct: 6707 MQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS----- 6761
Query: 8656 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8715
+ L+ + +Q S S DE+D SG P + P R K R
Sbjct: 6762 -QDLMALQGTQNPASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA-------------- 6804
Query: 8716 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 8775
R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+ LACL+P SEEDYSC
Sbjct: 6805 -VRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCT 6863
Query: 8776 LSNNFARSFHPMLRYTNGPPP 8796
+NNFARSF+PMLRYTNGPPP
Sbjct: 6864 QANNFARSFYPMLRYTNGPPP 6884
Score = 608 bits (1569), Expect = e-173
Identities = 1245/6222 (20%), Positives = 2449/6222 (39%), Gaps = 953/6222 (15%)
Query: 21 LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
LQ EQE QK+ FT WINS LA+ P V+ DLF D+K G LL LLEVLSGQ+LP ++G
Sbjct: 25 LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84
Query: 81 RRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTS 140
+ NI AL FL R IKL+NI+ TDI DG PSI+LGL+WTIIL+F IE+L
Sbjct: 85 SNTFQCRI--NIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
Query: 141 NLPQLQSLSSSASSVDSIVSSETPSPPSKR--KVTTKIQGNAKKALLKWVQYTAGKQTGI 198
L S V + SS SPP+K+ KV + Q +A+KALL W Q +
Sbjct: 143 TL-SCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESV 201
Query: 199 EVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDP 258
V DF SWR+G+AF ++IHA+RP+L+D+++VK RSN++NL +AF IAE EL IPRLL+P
Sbjct: 202 NVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEP 261
Query: 259 EDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRV 318
EDVDV PDEKSIMTYVAQFL++ D + Q + G+ +
Sbjct: 262 EDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQK----------- 310
Query: 319 IFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKL 378
++++ ++ E D KY S F + ++K ++ +L
Sbjct: 311 --EKLQKLLKDSEND---------TYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDEL 359
Query: 379 SLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEET 438
D ++++WD + ++ W I+L+ +LP PL AWL E + E+++ Q H +
Sbjct: 360 DKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQA 419
Query: 439 ANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIP-VPPDQLEDMAERFHFVSSTSE 497
IQ K+ K L+ + H + + N +P VPP++LE+M R + + +
Sbjct: 420 VTLIQEKMTLFKSLMDRFEHHSNIL-LTFENKDENHLPLVPPNKLEEMKRRINNI--LEK 476
Query: 498 LHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYE 557
++ +EF K +L L+ +SKL W IKYG RESVE LL+++ FIE +F + +
Sbjct: 477 KFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLD 536
Query: 558 VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDR 617
++Q + E+Y G + + +R + +V+S L++V++ W
Sbjct: 537 TSFQ---KCGEIYKNLAGECQNINKQYMMVKSDVCMYRK---NIYNVKSTLQKVLACWAT 590
Query: 618 YGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSR 677
Y + L+A E+ +K E K+ F L W +H +N+AGNFL+E +++V
Sbjct: 591 YVENLRLLRACFEETKK-----EEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGS 645
Query: 678 DLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEV 737
+ ++L LN RWR+L + + LE
Sbjct: 646 SISKELRRLNKRWRKLVSKTQ------------------------------------LE- 668
Query: 738 SFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP--QEEGKEMFATMSKLKEQ 795
MN+ L+I+ +Q P D I++K + S E E + K E+
Sbjct: 669 --MNLPLMIK-----KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEK 721
Query: 796 LTKVKECYSPLL---YESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFK 852
K E ++ L + ++L+ +E E + S D +++ T +E +
Sbjct: 722 HEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQ----DDVDTSMEESLKHLIAKG 777
Query: 853 QKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMV 912
EL+A E+ +++ Q++ + +VL Q ++Q + + ++V
Sbjct: 778 SMFDELMARSED------MLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQI---NVV 828
Query: 913 KKTGDWKK--HVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQL 970
K K V + + K EES+ ELE + AQ+ L ++ P EL+ +H E
Sbjct: 829 KLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIIS 888
Query: 971 DQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNR 1030
+ + L +LKA +EL + + E + L+E R + +W+ L E ++ LKID+EK +
Sbjct: 889 NTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGK 948
Query: 1031 FLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPV 1090
++ + ++++E KL+ + ++ +IKEH FS++G + ++++ ELC +LP
Sbjct: 949 LSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPS 1008
Query: 1091 RDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGI 1150
+ ++ LK+ I+ + E + S+ I+T+E +
Sbjct: 1009 QKSQQEVKR----LLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP 1064
Query: 1151 KGEA--IDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELA 1208
EA + N ++A+E T+ + S VL + E+ +K D A
Sbjct: 1065 HSEAPFAKSDNQPSTEKAME----------PTMKF--SLASVLRPLQEESIMEK--DYSA 1110
Query: 1209 KLSSSFKALVTLLSEVEKMLSN---------------FGDCVQYK----EIVKNSLE--- 1246
++S + T +E L N C+Q K +++KN +
Sbjct: 1111 SINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARW 1170
Query: 1247 ---ELIS--------------------GSKEVQEQAEKILDT--ENLFEAQQLLLHHQQK 1281
E+IS KE + + + L+T E+L A +L+L ++
Sbjct: 1171 KEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKA 1230
Query: 1282 TKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRK 1341
+ + + + Q DR ++ LR ++ ++ R E L++
Sbjct: 1231 SLLLCGSDLPLHKMAIQGFHLIDA--DRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKE 1288
Query: 1342 WERFETN--KETVVRYLFQ-TGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
F+ + + +++Y Q G +H S +L++L L + E + + +
Sbjct: 1289 LHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSAS 1348
Query: 1399 LVKEASEIPLGPQNKQ----LLQQQAKSIKEQVKKL----------EDTLEEDIKTMEMV 1444
+ A E L +NK+ L++ +AK + + +K L +DT E++ +
Sbjct: 1349 DTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSI 1408
Query: 1445 KTKWDH-FGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKV---TIQEI 1493
K H +G E TE+ K L N L + + QIS+I + T+ +
Sbjct: 1409 KLSETHGYGVQEE-----FTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAV 1463
Query: 1494 ESKLSSIV--------------GLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREH 1539
+ + S++ L+E A S F E + + +
Sbjct: 1464 KHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALV 1523
Query: 1540 AQCLE--GTILGHLSQQQKFEENLRKI---QQSVSEFEDKLAVPIKICSSATETYKVLQE 1594
+CLE G +L L Q Q F+ L + ++SV + + E V +E
Sbjct: 1524 TECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEE 1583
Query: 1595 HMDLCQALESLSSAI--TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALEN 1652
+ + ++ ++ F + K +EA + ++ DI + ++ L
Sbjct: 1584 FNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGR 1643
Query: 1653 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
LA W +L + W E+ K ++ DR +++ ELQ+ + +E + +
Sbjct: 1644 ALALWDKLFNLKNVIDEWTEKALQKMELHQL-TEEDRERLKEELQVHEQKTSEFSRRVAE 1702
Query: 1713 YSKLLQLKESLFSVASKDDVKMMKL-HLEQ--------------LDERWRDLPQIINKRI 1757
LLQ E + + + K+ H+++ E DL Q +I
Sbjct: 1703 IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQ-AKTQI 1761
Query: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA--------LTRHKDH 1809
+S++ D L + F+ ++ LQ + ++++Q+ L + +
Sbjct: 1762 GMTESLLKALSPSDSLEI-FTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYES 1820
Query: 1810 AAEVESKKGELQSLQGHLAKL--GSLGRAED-LHLLQGKAEDCFQLFEEASQVVERRQLA 1866
+++ + K + LQ H +KL D ++ ++CF+ E V ++ Q
Sbjct: 1821 VSDLFNTKKSV--LQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKL 1878
Query: 1867 LSHLA---------------EFLQSHASLSGILRQLRQTVEATNSMNKNES--DLIEKDL 1909
L + ++ H + + + V + K ES K+L
Sbjct: 1879 SDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKEL 1938
Query: 1910 NDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTK 1969
D+LQ L+ +L L+ + K G E L + E+ +++
Sbjct: 1939 EDSLQQLLRLQDDHRNLRKWLTNQEEKWK-GMEEPGEKTELFCQALARKREQFESVAQLN 1997
Query: 1970 QS-------EADALAVLKKAFQDQKEELLKSIEDIEER-----TDKERLKEPTR------ 2011
S E + + + D+ + LL+ + +IEE T+ + +
Sbjct: 1998 NSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI 2057
Query: 2012 QALQQRLRVFNQLEDELNSHEH-----ELCWLKDKAKQ-----IAQKDVAFAPEVDREIN 2061
+ +++ L V N E ++ E E+ LK + + Q + + AP V + +
Sbjct: 2058 KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLT 2117
Query: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDL 2121
+ WD+T L + + L K L++ + + +K +++
Sbjct: 2118 DISNQWDNTLHLAS----------TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEA 2167
Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTV--DKWL 2179
+A +H + K + K F K + L S LK++ S L++ + + WL
Sbjct: 2168 GFAL-QHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWL 2224
Query: 2180 DVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKE 2239
++ + L E++ + Q+ +++ NLD H+R
Sbjct: 2225 EI-KHLHESL---------------------------LQQLQDSVQNLDGHVR------- 2249
Query: 2240 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTL 2299
E + + + +L++ +++ + + P Q + +QKL+ + + GTL
Sbjct: 2250 ---EHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTL 2306
Query: 2300 KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISST 2359
K A + V++ + + K + + C Q KD++ L S + +
Sbjct: 2307 KKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQ----------KDLENRLASAKQEMECC 2356
Query: 2360 QENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQ-ESLEKHFSESMQEF 2418
LNS+ + S E + T ++ +A S + TQ S E LE+ + +
Sbjct: 2357 ---LNSILKSKRSTEKKG---KFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSA 2410
Query: 2419 QEWFLGAKAA--AKESSDRTGDSKVLEAKLHDLQN---ILDSVSDGQSKLDAVTQEGQTL 2473
E + + + A+ES T D E K+++LQN LD++ + +E + L
Sbjct: 2411 VEMAMSKQLSLNAQESMKNTED----ERKVNELQNQPLELDTMLRNEQ-----LEEIEKL 2461
Query: 2474 YAHLSKQ---IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLW 2530
Y L + I Q + E L Q L + L + +
Sbjct: 2462 YTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV 2521
Query: 2531 IHEMEE-----RFNTENLGESKQHIP----EKKNEVHKVEMFLGELLAARESLDKLSQRG 2581
+ + +E + + L K+ + + + K++ F+ + ++SL L +
Sbjct: 2522 LRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKW 2581
Query: 2582 QLLSEEGHGAGQEGRL----CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQ--- 2634
+ LS H + +L QL + + + ++K V E L +Q
Sbjct: 2582 ENLS--NHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
Query: 2635 -SMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGEGEVKLNMAIGKGEQ 2690
S+ + +Q RL E G++ + + ++KG+ E+++ G+ E
Sbjct: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKE- 2698
Query: 2691 ALRSSNKEGQRVIQTQLETLKE----------------------VWADIMSSSVHAQSTL 2728
+ + ++G ++ Q ETL+ +WA + ++ L
Sbjct: 2699 --KKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPL 2756
Query: 2729 --ESVISQ-------WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSI 2779
+ ++SQ + + R+ +E E V K+ P E L + L+ +
Sbjct: 2757 LPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV-----PSLTTYEGSDLNNTLEDL 2811
Query: 2780 LSEAEDHTRALHRLIAKSRELYEKTEDES--FKDTAQEELKTQFNDIMTVAKEKMRKVEE 2837
++ + + + +S++L K E+ S F + +L Q ++ + + + + E
Sbjct: 2812 RNQ---YQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEA 2868
Query: 2838 IVKDHLMYLDAVHEFTDWLHSA-KEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASR 2896
+K H + L+A + + S L +++ + + ++ +++ + + +I +R
Sbjct: 2869 ELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF--LEDQLKNLKIRTNR 2926
Query: 2897 LSR-VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSE 2955
+ R +++ EV+ C H + AL+ + DS+ + + L V++ E
Sbjct: 2927 IQRFIQNTCNEVEHK--IKFCRQFHEKTSALQEE----ADSIQRNELLLNQEVNKGVKEE 2980
Query: 2956 QEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQ-KAEP 3014
+ L+ L + L +L+ K + I W Q LD LQ +
Sbjct: 2981 ------IYNLKDRLTAIKCCI------LQVLKLKKVFDYIGLNWDFSQ--LDQLQTQVFE 3026
Query: 3015 RTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFR 3074
+ ++L+ ++ +L F + GK L+ + + LQ K + + R
Sbjct: 3027 KEKELEEKIKQLDTFEEE----HGKYQALLSKMRAIDLQIKK--MTEVVLKAPDSSPESR 3080
Query: 3075 DFQQWLVNAKITTAKCF--DIPQNISEVST--SLQKIQEFLSESENGQHKLNMMLSKGEL 3130
+++ +I AKC +I + ++E T K +E L N + + +
Sbjct: 3081 RLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNM 3140
Query: 3131 LSTLLTKE-KAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ-MKDFEVSAEPIQD- 3187
+ L KE K Q K+ + S L Q L NL+I+ +++ + + E Q+
Sbjct: 3141 VLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ--PLLINLEIKHIQNEKDNCEAFQEQ 3198
Query: 3188 -W--------LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI---------HCYEPQ 3229
W ++ EK E+S+ D+ K RE + LQ L YE
Sbjct: 3199 VWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYE-N 3257
Query: 3230 LNRLKEKAQQLWEGQAASKSF------------------RHRVSQLSSQYLALSNLTKEK 3271
L R KE + E + ++ + +L S + +LT EK
Sbjct: 3258 LTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLT-EK 3316
Query: 3272 VS-------------RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY-CHPTSDKSVLD 3317
+ L +V++++ K + T+A L++Y C+ ++ +
Sbjct: 3317 LGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE---TEAERYLENYKCYRKMEEDIYT 3373
Query: 3318 S------------RTLKL---EALLSVKQEKEIQMKMIVTRGESV----------LQNTS 3352
+ +L L EAL ++Q K + +I T+ E + L+ T
Sbjct: 3374 NLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTE 3433
Query: 3353 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
+GI + + + ++ + W SLL A + E +W + + + + +D+++ L
Sbjct: 3434 NDGI-CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEEL 3492
Query: 3413 NE--------SERQHAELRDKTTMLG----KAKLLNEEVLSYSSLLETI-EVKGAGMTE- 3458
E + + +EL D G K +LL +L ++ + E GA T
Sbjct: 3493 PEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVP 3552
Query: 3459 --HYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQ 3510
+T ++ LQ +Q+ +Q +E + +++++ L +Q+ +F+ Q
Sbjct: 3553 AFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQ 3612
Query: 3511 EQ-EKLDQYSVLEGDAHTHETTLRDLQE-LQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
+ EK +Q+ L+ + T ++ E L++ +E ++ + + ++ + + +
Sbjct: 3613 DHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDID 3672
Query: 3569 DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQ 3628
++ + + +Y M +K ++++ L E+ + +Q
Sbjct: 3673 EKISNEVLKSSPSY-------------------AMRRKIEEINNGLHNVEKML-----QQ 3708
Query: 3629 SNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT-SRYQ 3687
++ ++ Q Q K W +E+ + ++ E+ + Q+I+++ ++ + +YQ
Sbjct: 3709 KSKNIEKAQEIQKKMW-DELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQ 3767
Query: 3688 ALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKL 3747
+ + + L + +EE L S W +T N A D + T +
Sbjct: 3768 QVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPA-DYDSLRT--LSHHA 3824
Query: 3748 KTLEVLLKDMEKGHSLLKSA-REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRK 3806
T+++ L+D E+ H+LL S + + ++ + E + L + I + Q+ L + +
Sbjct: 3825 STVQMALEDSEQKHNLLHSIFMDLEDLSIIF----ETDELTQSIQELSNQVTALQQKIME 3880
Query: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE----EPKMELYEKKAQLSKYKSL 3862
+++ + K++ + +++ + IL E P+ L + L + +
Sbjct: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPM 3940
Query: 3863 QQT---VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEA 3919
++T ++S++ ++ + + G L + Q + +QL D + L ++ +E L+
Sbjct: 3941 KKTIAEIVSYQVELR-LPQTGMKPLPVFQ------RTNQLLQDIKLLENVTQEQNELLKV 3993
Query: 3920 KVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME-EIAGFED 3978
+K +++ E++ +++ L S + SLE ++ A ++ EI E
Sbjct: 3994 VIKQTNEWDEEIENLKQILNNYSAQF---------SLEHMSPDQADKLPQLQGEIERMEK 4044
Query: 3979 RLNNL-QMKGDTLIGQCADHLQAKLKQNVHAHLQG-----TKDSYSAICS----TAQRMY 4028
++ +L Q K D L+ A L N+H HL+ +D A+ S A+R
Sbjct: 4045 QILSLNQRKEDLLVDLKATVL------NLHQHLKQEQEGVERDRLPAVTSEEGGVAER-- 4096
Query: 4029 QSLEHELQKHVSR------QDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL 4082
+ E +L + S ++ +++ EPSPQ S + K ++ RA
Sbjct: 4097 DASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRAS 4156
Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL------------VQAQNL-- 4128
+ + N+ + D TEQ E L ++A L
Sbjct: 4157 SSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDS 4216
Query: 4129 --TQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELEL-----NIAQNMVSQVKDFVKK 4181
QG E + K+ + + L K + +ELEL N+A + D +
Sbjct: 4217 SDAQGGLEPRVEKTR-----PEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQV 4271
Query: 4182 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRD 4241
L+ + ++ ++ EHK + L + D N E L
Sbjct: 4272 LEQQLVGCQAMLTEI----------EHK-VAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320
Query: 4242 YHDC-MNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALA-----LQERKYAIEDL 4295
C + V++ L++ +E + S H EAL+ + L+ + ER
Sbjct: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380
Query: 4296 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL----EDLIKRKIQVSVTNLEELNVVQS 4351
Q+Q+++E ++ K+ +K + ++ W Q D + + + E +V S
Sbjct: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440
Query: 4352 ----RFQELMEWA---EEQQPNIAEALKQSPPPDMAQNL--------------------- 4383
+ Q +W E I L Q P ++ N+
Sbjct: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500
Query: 4384 ----LMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSD 4439
L D S L+ ++ + + + D+ + +L L Q + + D
Sbjct: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560
Query: 4440 LVGQRRKY---------LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVS 4490
GQ+ Y L ALS+K L+ + + +CL +
Sbjct: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620
Query: 4491 KQVKTCKSAQASL---KTYQNEVTGLWAQGRELMKEVT--EQEKSEVLGK--LQELQ--S 4541
++ KS +A L ++YQNE+ L+ Q L+K T +Q +E+ G+ ++LQ
Sbjct: 4621 AVCRS-KSLKAGLDYNRSYQNEIKRLYHQ---LIKSKTSLQQSLNEISGQSVAEQLQKAD 4676
Query: 4542 VYDSVLQKCSHRLQELEKN---------LVSRKHFKED-FDKACHWLK------------ 4579
Y L+ R+ +L L+ + ED D L+
Sbjct: 4677 AYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVT 4736
Query: 4580 --QADIVTFPEINLMNESSE--LHTQLAKYQNILEQSPEYENL----------LLTLQRT 4625
Q D + + L+ E H L + ++ + + EN +L +Q
Sbjct: 4737 ESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
Query: 4626 GQTILPSLNEVDHSYLSEK------LNALPRQFNVIVALAKDKFYKVQEAILARKEYASL 4679
ILPSL + ++ +E+ L RQ + + K+ + E + ++ +
Sbjct: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
Query: 4680 IELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEG 4739
+ T S+S +E R+ VE Q R I + A L + LN+ K+
Sbjct: 4857 LISTLPSVSLVEETEERL--------VERISFYQQIKRNIGGKHARLYQT---LNEGKQL 4905
Query: 4740 FRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKE 4799
S P ++ L + L ++ + + L+ + + QL + L+S +
Sbjct: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQH 4965
Query: 4800 EQSKVNEETLPAEEKLKMYHSLAGSL------QDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
+ E++L + L S + D LK I + + HL
Sbjct: 4966 TLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT 5025
Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELS--GPV 4911
R + ++ + +L + + + + ++ + + ++ + W+ V+ + S V
Sbjct: 5026 LRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSV 5085
Query: 4912 YLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFT---KAKELISADLEHSLA 4968
+ + ++ ++K + + E+ I++ ++ + T ++K + L
Sbjct: 5086 HSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLG 5145
Query: 4969 ELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESA 5028
E++ + L + L ++ Q N+WLE +E L+ V S
Sbjct: 5146 EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISV 5205
Query: 5029 EENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTGK--EDLEQKVASLELRS 5082
++ L + + L+EL TL+ PL++ T ++L QK +S+ +
Sbjct: 5206 QKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQV 5265
Query: 5083 QRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5142
++ +Q +W Y + +EV +M E S S ++
Sbjct: 5266 NQLKTS-------MQSVLQEWKIYDQLYDEV-NMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
Query: 5143 SEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQ 5202
++L S L+E +L+ ++ + T +RWT++ DQ
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNT-HKRWTQVNQAIADQ 5376
Query: 5203 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELE 5262
+ + + W ++N +A + Q + K + S L +L + EL+
Sbjct: 5377 LQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQ 5436
Query: 5263 QQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQEL 5322
Q S+L P P E M + L+ ++ K++ +
Sbjct: 5437 HDVQKTKEAFLQNSSVLD--RLPQPAESSTHM-----LLPGPLHSLQRAAYLEKMLLVKA 5489
Query: 5323 KDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQK 5382
+ E V +Q + +LE L+ L+ + + + +E
Sbjct: 5490 NEFEFVLSQFK------------------DFGVRLESLKGLIMHEEENLDRLHQQEKENP 5531
Query: 5383 EKYLGLYTILPSELS--LQLAEVALDLKIRD----QIQDKIKEVEQSKATSQELSRQIQ- 5435
+ +L L ++ L EV+L L + D +Q+ ++ ++ AT+ E ++Q
Sbjct: 5532 DSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQG 5591
Query: 5436 ------------KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAV 5483
K + L I LK N + +Q+ K++E + ++
Sbjct: 5592 IGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQK--------TYKMLEAEVSI 5643
Query: 5484 QK-----FLEQNGQL-------GKP-LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5530
+ ++ Q+ QL +P + KLT+ Q ++ R ++ +
Sbjct: 5644 NQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQ 5703
Query: 5531 EYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQT--LLEE--SKEIDSELEAM 5586
++ +E + +++ L SA + +E++ L+QT L+ E +KEI +
Sbjct: 5704 DFTTSVENLFRFLTDTSHLL-------SAVKGQERFSLYQTRSLIHELKNKEIHFQRRRT 5756
Query: 5587 T--------EKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
T EKL T + E + +++++L +++ + ++ Q + + E
Sbjct: 5757 TCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCE 5816
Query: 5639 AELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEME 5680
++K+L++ L+ +A P L E L + + L+ E+E
Sbjct: 5817 KKIKELKSRLQVLKAQSEDP---LPELHEDLHNEKELIKELE 5855
Score = 117 bits (292), Expect = 7e-25
Identities = 313/1701 (18%), Positives = 680/1701 (39%), Gaps = 250/1701 (14%)
Query: 1237 YKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQI 1296
Y+ +K +LI +Q+ +I + Q + QK + + + + ++
Sbjct: 4638 YQNEIKRLYHQLIKSKTSLQQSLNEI--------SGQSVAEQLQKADAYTVELENAESRV 4689
Query: 1297 AQAQ-QGEG-GLPDRGHEELRKLESTLD---GLERSRERQERRIQVTLRKWERFETNKET 1351
A+ + +GE LP +E+ KLE LD G+ R+R + VT + +
Sbjct: 4690 AKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
Query: 1352 VVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR--TESIAVQAENLVKEASEIPLG 1409
+V+ + + +H S +L +++E K F ++ + + +QA + A +P
Sbjct: 4750 LVK-IGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYS----AKILPSL 4804
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
QN++ + + +VK LE+ + ++ + KW+ F N+ +L EK+L
Sbjct: 4805 LQNRETFWAEQVT---EVKILEEKSRQCGMKLQSLLQKWEEFDENYASL-------EKDL 4854
Query: 1470 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1529
L ++ ++ + ++E E +L E SF Q + + A+L Q
Sbjct: 4855 EILISTLPSVSL--------VEETEERLV-------ERISFYQQIKRNIGGK-HARLYQT 4898
Query: 1530 RRYGEELREHAQC--LEGTILG----HLSQQQKFEENLRKIQQ------SVSEFEDKLAV 1577
G++L C LEG I LS +K + L ++Q S + D+L
Sbjct: 4899 LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTK 4958
Query: 1578 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1637
++ +K ++ +++ Q L+++ S I F +++V + S ++ Q
Sbjct: 4959 WLESSQHTLNYWK--EQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ-- 5014
Query: 1638 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1697
L KE TA L A + E++ + +T L + K +M+ R + +
Sbjct: 5015 --LLHLKETDTA--TLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070
Query: 1698 LIQALQNEVVSQASFYSK--------LLQ------------------LKESLFSVASKD- 1730
+ ++++ + S +S LLQ + +SL +++ D
Sbjct: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130
Query: 1731 -----DVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
+ HL +++ +W + ++N++I L+ ++ + + + + W++
Sbjct: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
Query: 1786 SELQTTSEI-SIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1844
L+T + S++ Q L +D ++ K L L+ L S + LL+
Sbjct: 5191 ERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA----VPLLED 5246
Query: 1845 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQ-TVEATNSMNKNESD 1903
A +LF++ S V+ + + + LQ + ++ T+ M ++
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
Query: 1904 LIEKD-LNDALQNAKALESAAVSLDGILSKAQYHLK------------IGSSEQRTSCRA 1950
++ + L ++N ++L+ A S +G K Q + I Q T R
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
Query: 1951 TA--DQLCGEVERIQNLLGT---------------KQSEA--DALAVLKKAFQDQKEELL 1991
T + ++++ Q+LL KQ EA LA + + + E L
Sbjct: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
Query: 1992 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC----WLKDKAKQIAQ 2047
+++DI+E + + T++A Q V ++L S H L +A + +
Sbjct: 5427 PALQDIKEL---QHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
Query: 2048 KDVAFAPEVDREINRLE---VTWDDTKRLI-HENQGQCCGLIDLMREYQNLKSAVSKVLE 2103
+ A E + +++ + V + K LI HE + +L R +Q K L
Sbjct: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE-------NLDRLHQQEKENPDSFLN 5536
Query: 2104 NASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSD 2163
+ ++ I+ ++ + A + + T+ SEL+ I ++
Sbjct: 5537 HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE 5596
Query: 2164 FSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAEN 2223
L +KW+ + EK+EE L+V ++ N +P++ E
Sbjct: 5597 KFLY------CCEKWIQLLEKIEE---ALKVDVA-----------------NSLPELLEQ 5630
Query: 2224 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ 2283
++ K E+EV + ++ L + T+ +E P+ + L
Sbjct: 5631 ----------QKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE-IENRPEFITEFSKLTD 5679
Query: 2284 KLEHAKEITEVAKGTL-------KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETC 2336
+ ++A + KG + +DFT + +F+ D + L++ + +
Sbjct: 5680 RWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS--------HLLSAVKGQER 5731
Query: 2337 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2396
+L + + + EL++++ + + + C A + L +T +K E+V +
Sbjct: 5732 FSLYQTRSLIHELKNKEIHF----QRRRTTCALTLEAGEKLL---LTTDLKTKESVGRRI 5784
Query: 2397 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK-------LH-D 2448
S+ Q S ++ +E +E +++FQ K+ + +VL+A+ LH D
Sbjct: 5785 SQLQDSWKD-MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHED 5843
Query: 2449 LQNILDSVSDGQSKLDAVTQ---EGQTLYAHLSKQI----VSSIQEQITKANEEFQAFLK 2501
L N + + + + L + TQ E QT+ A L++ + V ++EQI + +++
Sbjct: 5844 LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903
Query: 2502 QCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER-FNTENLGESKQHIPEKKNEVHKV 2560
+ KQ ++D + F +++++L W+ +ME + T ++ + +K+ + ++
Sbjct: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEI 5963
Query: 2561 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2620
+F L ++ D+L + S + A + +L +++ Q+L + +++ +
Sbjct: 5964 NLFSENKLQLKQMGDQLIKA----SNKSRAAEIDDKL-NKINDRWQHLFDVIGSRVKKLK 6018
Query: 2621 VALQEHEALEEALQSMWFWVKAIQDRLAC-AESTLGSKDTLEKRLSQIQDILLMKGEGEV 2679
+ L++ + ++ W+ I+ L+ + ++KRL++ QD+ +
Sbjct: 6019 ETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSA 6078
Query: 2680 KLNMAIGKGEQALRSS----NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2735
+ + L S N+ IQ +L W +I + S+ + +E W
Sbjct: 6079 GVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLW 6138
Query: 2736 NDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
+++ ++ E W++S ++ P + VL + L E R +H +
Sbjct: 6139 QKFLDDYSRFEDWLKSAERTAACPNSSE-------VLYTSAKEELKRFEAFQRQIHERLT 6191
Query: 2796 K---SRELYEKTEDESFKDTA 2813
+ + Y + E+ DTA
Sbjct: 6192 QLELINKQYRRLARENRTDTA 6212
Score = 105 bits (262), Expect = 2e-21
Identities = 352/1983 (17%), Positives = 759/1983 (38%), Gaps = 301/1983 (15%)
Query: 1211 SSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE----ELISGSKEVQEQAEKILDTE 1266
+ K T L ++ + SN E +L+ EL + E++L+
Sbjct: 4495 TEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMP 4554
Query: 1267 NLF--EAQQLLLHHQQ---KTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1321
L+ + +H++ + K++ D + + +A G + E L+ L
Sbjct: 4555 RLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1381
+ + + + + ++ L ++ + + L ++ +S ++ L+ S +S++ +L++
Sbjct: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQK 4674
Query: 1382 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1441
++ E+ + L E + L ++ ++V KLED L+
Sbjct: 4675 ADAYTVELENAESRVAKLRDEGERLHL-----------PYALLQEVYKLEDVLDS---MW 4720
Query: 1442 EMVKTKWDHFGSNFETLS------------VWITEKEKELNALETSSS--AMDMQISQIK 1487
M++ ++ S F T S V I +++ L+ + S A+ QI K
Sbjct: 4721 GMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHK 4780
Query: 1488 VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTI 1547
V Q++ ++ ++ ++ + + ++T+++ E+ R+ L+
Sbjct: 4781 VFFQKL---VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL- 4836
Query: 1548 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE---- 1603
L + ++F+EN +++ + + L + S ET + L E + Q ++
Sbjct: 4837 ---LQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
Query: 1604 SLSSAITAFSASARKVVNRDSCVQ---EAAALQQQYEDILRRAKERQTALENLLAHWQRL 1660
+ + +++V SC + + A L++Q+ + ++ L+ LL H
Sbjct: 4890 GKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSY 4949
Query: 1661 EKELSSFLTWLERGEAKAS---SPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1717
++ WLE + + +++S D + + EV ++S + ++
Sbjct: 4950 NRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVI 5009
Query: 1718 QLKESLFSVASKDDVKMMKLHLEQLDERWR----DLPQIINKRINFLQSVVAEHQQFDEL 1773
+ L + + D ++ L Q +++W LP I K + + E+
Sbjct: 5010 SIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
Query: 1774 LLSFSVWIKLFLSELQTTSEISIMDHQVA------LTRHKDHAAEVESKKGELQSLQGHL 1827
+ W+ E QT+ E S+ A L +HK+ E++ K+ + + L
Sbjct: 5069 IS----WMNNV--EHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
+L + + S+ ER + A HL E + + G+L +
Sbjct: 5123 LQLSTC--------------------DVESKRYERTEFA-EHLGEMNRQWHRVHGMLNRK 5161
Query: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947
Q +E L++ E+ L+ L + LK + Q+
Sbjct: 5162 IQHLE------------------QLLESITESENKIQILNNWLEAQEERLK---TLQKPE 5200
Query: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
+ +L + + I+N L K AL LK+++ + + +ED R D+ K
Sbjct: 5201 SVISVQKLLLDCQDIENQLAIKSK---ALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
Query: 2008 -----------EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEV 2056
+ + Q++ Q ++++QL DE+N + + +K + +V
Sbjct: 5258 RSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
Query: 2057 DR------EINRLEVTWDDTKRLIHENQGQCCGLIDLMRE--------YQNLKSAVSKVL 2102
+ E E +W+ + +I + +G C + +++ E + + A++ L
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
Query: 2103 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2162
+ A S++ + A K + AK + L N + G +L +E+
Sbjct: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQ------LANISMSGNNL-AEILPPALQ 5430
Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2222
D ++ D++ T + +L S L DRL E ++ +P
Sbjct: 5431 DIKELQHDVQKTKEAFLQNSSVL----DRLP-------------QPAESSTHMLLPGPLH 5473
Query: 2223 NISNLDNHLRAEELLK--EFE---SEVKNKALRLEELHSKV----NDLKELTKNLETPPD 2273
++ +L L+K EFE S+ K+ +RLE L + +L L + + PD
Sbjct: 5474 SLQRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPD 5532
Query: 2274 --LQFIEADLMQK--LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2329
L + A Q +EH E++ K L D ++ Q N W +L
Sbjct: 5533 SFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAVKTLQ-----NMNRQWIRATATALER 5585
Query: 2330 CAQ------NET----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE-SL 2378
C++ NE CE K ++ ++K ++ + +++++ L + Y E E S+
Sbjct: 5586 CSELQGIGLNEKFLYCCE--KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643
Query: 2379 GRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2438
+ + QL T+ + FS+ +Q G + R GD
Sbjct: 5644 NQTIADSYVTQSL--QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR-------QRKGD 5694
Query: 2439 SKVLEAKLHD----LQNILDSVSDGQSKLDAVT-QEGQTLYA-----HLSKQIVSSIQEQ 2488
L + D ++N+ ++D L AV QE +LY H K Q +
Sbjct: 5695 VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRR 5754
Query: 2489 ITKANEEFQAFLKQCLK-DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT--ENLGE 2545
T +A K L D + + + +D + + + EM ++F + E +
Sbjct: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ 5814
Query: 2546 SKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSH 2605
++ I E K+ + ++ + L E + L +L+ E + +L T
Sbjct: 5815 CEKKIKELKSRLQVLKAQSEDPLP--ELHEDLHNEKELIKELEQSLASWTQNLKELQTMK 5872
Query: 2606 QNLLR--------MTKEKLRSC---------QVALQEHE---------ALEEALQSMWFW 2639
+L R + KE++ +VA+++ E E + + W
Sbjct: 5873 ADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAW 5932
Query: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2699
+ +++++ + + ++ +EK + + + E +++L G+Q +++SNK
Sbjct: 5933 LVQMENKVL-QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQM---GDQLIKASNKSR 5988
Query: 2700 QRVIQTQLETLKEVWA---DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2756
I +L + + W D++ S V + I Q + + + L W+ ++ ++
Sbjct: 5989 AAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLD---KNMSNLRTWLARIESEL 6045
Query: 2757 EHPL--------QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES 2808
P+ + Q L E+ L ++ + E L+ S +TE +S
Sbjct: 6046 SKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDS 6105
Query: 2809 FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD 2868
+ T + L ++ +I ++ E+ K+EE + +LD F DWL SA+ +
Sbjct: 6106 IQQTTRS-LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNS 6164
Query: 2869 MSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRA 2928
++ +++L + + R+I RL+++E + + ++ + + Q +
Sbjct: 6165 SEVLYTSAKEELKRFEAF--QRQI-HERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221
Query: 2929 DWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE- 2987
++W++ L+ V+ + + F+ Q + E E L QLT +E
Sbjct: 6222 GNQRWDN--------LQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH 6273
Query: 2988 --GKNTDEEIVECWHKGQEIL--------------DALQKAEPRTEDL-KSQLNELCRFS 3030
+ D+++ + QEI +QK+EP L + +L EL R+
Sbjct: 6274 FSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYC 6333
Query: 3031 RDL 3033
+++
Sbjct: 6334 QEV 6336
Score = 98.6 bits (244), Expect = 2e-19
Identities = 314/1723 (18%), Positives = 639/1723 (37%), Gaps = 255/1723 (14%)
Query: 481 QLEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAESKLKSWI----- 527
+L D ER H + + + K+E L +Y LS + ES+ + +
Sbjct: 4691 KLRDEGERLHLPYALLQ-EVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
Query: 528 -IKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMK- 585
+K G+ + L+ S + E ++V +Q K A+M + S + ++++
Sbjct: 4750 LVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ--KLVADMLLIQAYSAKILPSLLQN 4807
Query: 586 ---FMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQ-------------AWL 629
F E + + L + R L+ ++ W+ + ASL+ + +
Sbjct: 4808 RETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLV 4867
Query: 630 EDAEKMLNQSENAKKDFFRNL-PHWIQQHTAMNDAGNFLIE-TCDEMVSR--DLKQQLLL 685
E+ E+ L + + + RN+ + + +N+ + +C E+ + L++Q L
Sbjct: 4868 EETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLS 4927
Query: 686 LN-------GRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVS 738
LN R + L + Y + + D++ K TL+ + E +S+ L+
Sbjct: 4928 LNKKIDHELHRLQALLKHLLSYNR--DSDQLTKWLESSQHTLN-YWKEQSLNVSQDLDTI 4984
Query: 739 FMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTK 798
N+ + ++++++ + A I + HL KE+ + A + L
Sbjct: 4985 RSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL--KETDTATLRASLAQFEQKWTMLIT 5042
Query: 799 VKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSAL--FKQKHQ 856
L++ Q +P + +M S+ +++ + + +S + QKH+
Sbjct: 5043 QLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHK 5102
Query: 857 ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTG 916
E + +++ +QS+ + T K +++T + +++ + +
Sbjct: 5103 EF---RMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLN 5159
Query: 917 DWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD-QRVL 975
+H+E + + E L L +E L+ PE ++ D + L
Sbjct: 5160 RKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQL 5219
Query: 976 NAFLKACDEL-----------------------------TDILPEQEQQGLQEAVRKLHK 1006
KA DEL + +L + Q L+ +++ + +
Sbjct: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ--LKTSMQSVLQ 5277
Query: 1007 QWK---DLQGEAPYHLLHLKIDVEKNR-FLASVEECRTELDRETKLMPQ----EGSEKII 1058
+WK L E + +E ++ + S+E R +++ L + EGS + +
Sbjct: 5278 EWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL 5337
Query: 1059 KEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRK 1118
+E V KG LC ++IEE C H ++ AI +K
Sbjct: 5338 QE--VIGKLKG---LCPSVAEIIEEKC-------------QNTHKRWTQVNQAIADQLQK 5379
Query: 1119 LMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV----KRAVEEIRNGV 1174
WK Y++ E ++ + E + + + ++ N E+ + ++E+++ V
Sbjct: 5380 AQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDV 5439
Query: 1175 TKRGETL---SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1231
K E S + RL E S+ L + + K L+ +E E +LS F
Sbjct: 5440 QKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
Query: 1232 GD----CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISA 1287
D K ++ + E L ++ +E + L+ AQ + H + +
Sbjct: 5500 KDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-LKL 5558
Query: 1288 KKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ----ERRIQVTLRKWE 1343
DV + Q + + +T LER E Q + KW
Sbjct: 5559 PLSDVAVKTLQNMNRQW------------IRATATALERCSELQGIGLNEKFLYCCEKW- 5605
Query: 1344 RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEA 1403
Q E L SL LEQ K + ++AE + +
Sbjct: 5606 -------------IQLLEKIEEALKVDVANSLPELLEQQKTYK------MLEAEVSINQT 5646
Query: 1404 SEIPLGPQNKQLLQ----QQAKSIKEQVKKLEDTLEEDIKTMEMVK-------TKWDHFG 1452
Q+ QLL + + KL D + ++ + K +W F
Sbjct: 5647 IADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT 5706
Query: 1453 SNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQ 1512
++ E L ++T+ L+A++ + Q + I E+++K + + + A
Sbjct: 5707 TSVENLFRFLTDTSHLLSAVKGQER---FSLYQTRSLIHELKNK---EIHFQRRRTTCAL 5760
Query: 1513 FVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVS 1569
+ GE + L + R +L++ + +E + + Q Q E + ++ +
Sbjct: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
Query: 1570 EFEDKLAVPIKICSS--ATETYKVLQEHMDLCQALE--------SLSSAITAFSASARKV 1619
E + +L V +K S E ++ L +L + LE +L T + R V
Sbjct: 5821 ELKSRLQV-LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHV 5879
Query: 1620 VNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAK 1677
+ D V ++ L +Q+ED+ R R+ +E+ L W ++ WL + E K
Sbjct: 5880 LVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK 5939
Query: 1678 ASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYS----KLLQLKESLFSVASKDDVK 1733
DIS + ++I+ LQ + + + + +S +L Q+ + L ++K
Sbjct: 5940 VLQ-TADISIE--------EMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA 5990
Query: 1734 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1793
+ L ++++RW+ L +I R+ L+ A QQ D+ + + W+ SEL
Sbjct: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050
Query: 1794 ISIMDHQVALTRHKDHAAEVESKKGELQSLQ----GHLAKLGSLGRAEDLHLLQGKA--- 1846
+ D Q E++ + E Q LQ H A + S+ D+ L A
Sbjct: 6051 YDVCDDQ-----------EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACAN 6099
Query: 1847 EDCFQLFEEASQVVERRQLALSHLA---------------EFLQSHASLSGILRQLRQTV 1891
E ++ ++ ++RR + ++ +FL ++ L+ +T
Sbjct: 6100 ETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTA 6159
Query: 1892 EATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAT 1951
NS S+++ + L+ +A + L + + E RT +
Sbjct: 6160 ACPNS-----SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
Query: 1952 ADQLCGE-VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDI-----EERTDKER 2005
Q+ E +R NL Q A+ + F +Q+EE + E I E
Sbjct: 6215 LKQMVHEGNQRWDNL----QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTN 6270
Query: 2006 LKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
++ + ++R N + E+ + +++ L +Q+ QK
Sbjct: 6271 VEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
Score = 90.9 bits (224), Expect = 5e-17
Identities = 420/2300 (18%), Positives = 883/2300 (38%), Gaps = 390/2300 (16%)
Query: 6582 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 6637
NQN+ ++E+ ++ TGQ K+A D + ++ E E + +LD+
Sbjct: 713 NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
Query: 6638 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 6694
+T + + + K + F ELMA++ +L+ + +++L T
Sbjct: 762 ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
Query: 6695 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 6754
+ + Q+ VV+ L + + D +D + + L Y + Q+L +
Sbjct: 815 KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
Query: 6755 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 6809
S +L S+ + +SNT ++K L +E + + T + +S D+
Sbjct: 873 ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
Query: 6810 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 6869
+S L + QQ + + E + D++ L+ K+++ + L +
Sbjct: 925 KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
Query: 6870 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6929
++ T L E S+ L + E L +L ++LPS+ + EV L+++
Sbjct: 968 RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
Query: 6930 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6989
QK E +K + IH LQ G N +T + +S
Sbjct: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
Query: 6990 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 7035
T+ A + +L+ L E I + LLE + Y +NN +
Sbjct: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
Query: 7036 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 7095
+ F ++E R + +Q L D Q +++ A+ KE E I + + K+
Sbjct: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
Query: 7096 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7154
TL+E + L+ + L+ L+ VL K + S L + ++
Sbjct: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
Query: 7155 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7214
F L+ +A ++ +L+N+QD + KQ + N +LKE HP + N +
Sbjct: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
Query: 7215 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7274
+ ++ + + + KAL +D+ + E T+ +A++ +
Sbjct: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
Query: 7275 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 7331
A + T + L+K D + ++ + ++ D S + + + + LS+
Sbjct: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
Query: 7332 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 7384
H +++ ++ L+A + K+++ +++ I + + +DP+
Sbjct: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
Query: 7385 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7444
L + + ++E + + MA L + G +N ++ + L + + ++
Sbjct: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
Query: 7445 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 7501
E+ ++ L Q+Q F ++ + L+Q E+ + + + +Y ++L ++ E+ +
Sbjct: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
Query: 7502 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7558
E ++ ++ + + Q L + + + F + ++ ++W + + + +
Sbjct: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
Query: 7559 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7618
+ W + + + +W + + L Q T D + KE++ + +Q
Sbjct: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
Query: 7619 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 7672
+ + + L S LQ + I K + L + A L
Sbjct: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
Query: 7673 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 7728
+D ++ + I + L+ S + EE+ + ++ K LEN +G T +L
Sbjct: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
Query: 7729 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7788
++L +++S + N + +LQ + +L + + N+W FS
Sbjct: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
Query: 7789 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 7843
L E E+K S +E+ ++KL E + +KI+ L+ + + L
Sbjct: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
Query: 7844 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7900
KA + S + E++L K+ + AR K+L+++L + +L + +LR W
Sbjct: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
Query: 7901 LAHIE------------------------------------------SELAKPIVYDSCN 7918
L + E +E + I+ +C
Sbjct: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
Query: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7978
+ Q L + E++ + + T S +L ++H + + L+
Sbjct: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
Query: 7979 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 8027
R + I + E +IE + L QK L D S W + + + S
Sbjct: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
Query: 8028 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 8070
G Y +KE ELKK + A Q + E QL++ K ++
Sbjct: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
Query: 8071 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
D LK++ +GN + W ++ S+L++L+ + +
Sbjct: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
Query: 8118 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 8168
DS V +T+++ L N E S D V+ K+++L+ + +SL +++I+A
Sbjct: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
Query: 8169 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 8211
+ + + + + II++++ L+ C + +R +K
Sbjct: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
Query: 8212 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 8268
+ LP E SD + ++SAA+ L W + + DS + S LSL+ + +++
Sbjct: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
Query: 8269 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 8317
R + + PLE D L LE+ + P E E + +
Sbjct: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
Query: 8318 LRGAVGLSGDH-SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 8376
+ +G S H L + L K + ++ + + + + L T +
Sbjct: 2490 VLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG 2549
Query: 8377 LGECSSSIDSVKRLEHKLKEEEESLPGF------VNLHST-------ETQTAGVIDRWEL 8423
+ + +D +K+ +++E++SL ++ H T E+Q + WE
Sbjct: 2550 PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQ 2609
Query: 8424 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 8483
++ Q K Q + ++ +F + +N + DTE L+Q Q+ LQ+
Sbjct: 2610 VEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ----------HLQL- 2651
Query: 8484 KLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKESRDLQDRLSQMNG 8529
+LK ++ ++ I L+ +L + + QA+ KE ++L+D ++ +
Sbjct: 2652 RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKK 2711
Query: 8530 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ 8589
+W+ LE ++ + +C ++M +L +N+ N +P+ L +IL
Sbjct: 2712 QWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSIPL---LPDDILS 2763
Query: 8590 DHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKEKVHVIGNRLKLL 8645
K ++ H+ +L Q V SL + L EG+D E + N+ ++L
Sbjct: 2764 QIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLR---NQYQML 2818
Query: 8646 LKEVSRHIKELEKLLDVSSS 8665
+ + ++ ++LE L+ S+
Sbjct: 2819 VLKSTQRSQQLEFKLEERSN 2838
Score = 79.3 bits (194), Expect = 2e-13
Identities = 565/3062 (18%), Positives = 1152/3062 (37%), Gaps = 460/3062 (15%)
Query: 5160 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5219
V L E +Q K G K + +T VA+D EK++ V+ W
Sbjct: 706 VELPENYNQNIKAGEKHEKEN---------EEFTGQLKVAKDVEKLIGQ-VEIWEAEAKS 755
Query: 5220 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ---QQSALGMLRQQTL 5276
V ++ +++ L A+ + EL+ E D ++++ Q+S +L
Sbjct: 756 VLDQDDVDTSMEESLKHLIAKGSMFDELMARSE--DMLQMDIQNISSQESFQHVLTTGLQ 813
Query: 5277 SMLQDGAAPTPGEEPPLMQEITAMQDRC--LNMQEKVKTNGKLVKQELKDREMVETQINS 5334
+ +Q+ L+ + + D L+++ K++ + K ++ + + + Q S
Sbjct: 814 AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRES 873
Query: 5335 VKCWVQETKEYLG-NPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5393
+ + KE L + T + L+ ++ L T ++I+ EE+ + L
Sbjct: 874 PGELISKHKEALIISNTKSLAKYLKAVEELKNNVT---EDIKMSLEEKSRDVCAKWESLH 930
Query: 5394 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5453
ELSL + ++ +D++ + ++ D I ++E+ ++L R+ + K L ++
Sbjct: 931 HELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGR--TKGLIKEHEACFSEEG 987
Query: 5454 NVVQAKTDQKVLG---EELDGCNSK------LMELDAAVQKFLEQNGQLGKPLAKKIGKL 5504
+ Q +VL EEL S+ L + + +++ L+ ++ L G
Sbjct: 988 CLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG- 1046
Query: 5505 TELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLRE 5564
T ++ TI +ENR + A + N+ EKA T+ ++ AS LR
Sbjct: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDNQ------PSTEKA---MEPTMKFSLASVLRP 1097
Query: 5565 QYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIK 5621
+ ++++E K+ + + ++ E+ + + + ++ E + ++
Sbjct: 1098 --LQEESIME--KDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQ 1153
Query: 5622 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV--GRLSLKEQLSHRQHLL-SE 5678
+L +LQ + E + + LE + P V R +LKE+ Q L +
Sbjct: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213
Query: 5679 MESLKPKVQAV--------QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ- 5729
MESL+ ++ V LC S L + + + L A R+ + +Q + +Q
Sbjct: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDAD-RIYQHLRNIQDSIAKQI 1272
Query: 5730 --CN-------------------IMQAAVVQYEQYEQEMKHLQQLIEGAHREIED----- 5763
CN MQ +++Y+ + M H Q E + +ED
Sbjct: 1273 EICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASL 1332
Query: 5764 --KPVATSNIQELQAQISR-HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5820
++ + +L A ++ +E +K + +I + K K L K M E
Sbjct: 1333 RTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
Query: 5821 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE-----EGTNSEISS 5875
LD + H V + LL ++ E + S+IS
Sbjct: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452
Query: 5876 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEFYEPGLEPSAT 5934
+ P T +V L + + K H A S ++ G E +
Sbjct: 1453 -IGLKDP-----TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
Query: 5935 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSESPEP 5992
+ + WE K +++E LE ++YQ+ ++T ++ E + L S
Sbjct: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
Query: 5993 GRSPESQMAEHQALMDEI---LMLQDEINELQSSLAEEL-VSESCEADPAEQ-------- 6040
+ + ++AE + + +E L + D+IN++ +L L ++ E P E+
Sbjct: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
Query: 6041 ------------------LALQSTLTVLAERMSTIRMKASGKRQL--LEEKLNDQLEEQR 6080
LAL L L + KA K +L L E+ ++L+E+
Sbjct: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
Query: 6081 Q--EQALQRYRCEADELDSWLLSTKATLD---------TALSPPKEPMDMEAQLMDCQNM 6129
Q EQ + E+ L S++ L+ + ++ + E+
Sbjct: 1687 QVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGS 1746
Query: 6130 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRA--LHDKQ 6187
E+ + + E+LL KA + ++ ++ KL ++ +L+ + + L + Q
Sbjct: 1747 TAELREDLDQAKTQIGMTESLL---KALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQ 1803
Query: 6188 LNM----QGTAQEKEESDVDLTATQSPGVQ---------------EWLAQARTTWTQQRQ 6228
+ +++ ES DL T+ +Q +W + + + +
Sbjct: 1804 IGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFE 1863
Query: 6229 SSLQQQKELEQEL----------------AEQKSLLRSVASR--------------GEEI 6258
SS + +K +EQ+L + S+L+ V G+E
Sbjct: 1864 SS-ETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEF 1922
Query: 6259 LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE---DQMRMKWESLHQEFSTKQKLLQN 6315
++ + A E D L Q L ++ + + KW+ + +E K +L
Sbjct: 1923 ELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM-EEPGEKTELFCQ 1981
Query: 6316 VLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ 6375
L +++EQ + +L + + Y + T L+D ++S K
Sbjct: 1982 ALARKREQ--FESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLL 2039
Query: 6376 SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMD- 6434
+Q D W+ +++E L V L E + L + K+I + E D
Sbjct: 2040 PTE-DQSFNDLAHDVIHWIKEIKESLMV---LNSSEGKMPLEERIQKIKEIILLKPEGDA 2095
Query: 6435 KNKNLFSQAFPENGDNRDVIEDTLGCLLGRL-SLLDSVVNQRCHQMKERL--QQILNFQN 6491
+ + + QA +++ TL + + + L HQ K L ++ L +
Sbjct: 2096 RIETIMKQA---ESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKE 2152
Query: 6492 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6551
DL+++ L + + E+ Q++ ++ ++ + + ELK +G+ L
Sbjct: 2153 DLRLMLIELKKKQEAGFALQHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLL 2210
Query: 6552 --VEQPSMQE--LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6607
+ PS E +++ +++ L+ + L+ ++ Y+ + DL L+ +
Sbjct: 2211 ECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSK 2270
Query: 6608 KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFA--VQKETQFHTE 6665
+ + S K Q +++ + Q LE+ + L + +KI++ A V++ T +
Sbjct: 2271 EF-----VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQ 2325
Query: 6666 LMAQASAVLKRAHKRGVE-------------LEYILETWSHLDE------DQQELSRQLE 6706
+ + + ++ +E L IL++ ++ +E +
Sbjct: 2326 KIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSD 2385
Query: 6707 VVESSIPSVGLVEENEDRLIDR---ITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 6763
V ES+ S + + ED I++ + + + SLN Q + D+ K +
Sbjct: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNA-QESMKNTEDERKVNELQNQPL 2444
Query: 6764 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ----SESADLI-HWLQSAKDRL 6818
+L++ L L K+ +L + +K + + +E+ L+ H + + L
Sbjct: 2445 ELDTMLRNE---QLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHL 2501
Query: 6819 EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6878
+ Q +T+ + E L F E+ V +SS+K+ L T + L++ +D+ T
Sbjct: 2502 DNLLQALITLKKNKESQYCVLRDFQEYLAAV--ESSMKA--LLTDKESLKVGPLDSVTYL 2557
Query: 6879 SELSRIDS---QWTDLLTNIPAVQEKL--HQLQMDKLPSRHAISEVMSWISLMENVIQKD 6933
++ + + + D L N+ E L H MDK I ++ +E IQK
Sbjct: 2558 DKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKK 2617
Query: 6934 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 6993
+ + Y + K + +I + +Q + L++ S + +
Sbjct: 2618 YS--QQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ------LRLKSPEERAGNQSMIALT 2669
Query: 6994 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK-RLKQQHRIG 7052
L A + +L+G +++ + G E E+ + LK +ET E L+ +++I
Sbjct: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK-KNLEDGINNLKKQWETLEPLHLEAENQI- 2727
Query: 7053 DQASVQNALKD-----------------------------CQDLEDLIKAKEKEVEKIEQ 7083
+ ++N +K+ C+ D I A+++ VE + +
Sbjct: 2728 KKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAE 2787
Query: 7084 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 7143
+ + S + +TL +L + L Q L+ L++ S+ K
Sbjct: 2788 EVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
Query: 7144 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 7203
+ E+ +L R+ T + EA L++ LE ++ LQ+ S + L+E
Sbjct: 2848 LMVQESE-TLIIPRVETAATEA------ELKHHHVTLEASQKELQEIDSGISTHLQE--- 2897
Query: 7204 PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY--------KDYSKQC---- 7251
LTN +E+N+ LE +QL++ K QR+ + K C
Sbjct: 2898 -----LTNIYEELNVFERLFLE---DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFH 2949
Query: 7252 --ASTVQQQED---RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHEL 7306
S +Q++ D R LL NK + ++ I + D L + + L ++
Sbjct: 2950 EKTSALQEEADSIQRNELLLNQEVNKGVKEE-----IYNLKDRLTAIKCCILQVLKLKKV 3004
Query: 7307 GEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEA 7366
+ + D S +Q+ + L + KQ + + Y+ + A++
Sbjct: 3005 FDYIGLNWDFSQLDQLQTQVFEKEKEL----EEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060
Query: 7367 WIVE-AEEILQGQDPSHSS---DLSTIQERMEELK---GQMLKFSSMAPDLD------RL 7413
I + E +L+ D S S + + +R+E+ K +++K + D +
Sbjct: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120
Query: 7414 NELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7473
++ NDK K +QN+ +L L + +K ET + L
Sbjct: 3121 LQIKLNAEENDKLYKVLQNM--------------VLELSPKELDEKNCQDKLETSLHVLN 3166
Query: 7474 QTEQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSI-IIDGQRLLEQGQVDDR 7530
Q + +L + N + H+ ++ E FQ ++++ + ++ I+ QR + D
Sbjct: 3167 QIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASD- 3225
Query: 7531 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 7590
KL + + R +++ RY+E + + ++ L
Sbjct: 3226 --VETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTR--------AVESITSL 3275
Query: 7591 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL--LSADSGAEAALQ---- 7644
++ IP R + ++ LR+Q TV + L L S EA LQ
Sbjct: 3276 EAIIIPY---RVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYT 3332
Query: 7645 -AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDH 7703
EL K A E + ++ K + K E+ I +L K+ T + SLP
Sbjct: 3333 LQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLS 3392
Query: 7704 HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEE 7763
+ E + K L + + S ++L +L + L + +D L + V L +W
Sbjct: 3393 YREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLS 3452
Query: 7764 LCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQ 7823
L E EW ++ E+ K+ EW + S+ + I+++ + E+L
Sbjct: 3453 LL-----------EAAKEWEMWCEELKQ--EW--KFVSEEIEREAIILDNLQEEL----- 3492
Query: 7824 EEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK-- 7881
EI+ +E A S+ + + G+ ++ Q LL L+ R++ ++
Sbjct: 3493 PEISKTKE-----------AATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNV 3541
Query: 7882 -------ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR 7934
ET+ A Q++ L ++ N E +Q ++ E+ +
Sbjct: 3542 PESSGAVETVPAFQEITSMKERCNKLLQKVQK-----------NKELVQTEIQERHSFTK 3590
Query: 7935 DI 7936
+I
Sbjct: 3591 EI 3592
Score = 67.0 bits (162), Expect = 8e-10
Identities = 316/1695 (18%), Positives = 635/1695 (37%), Gaps = 300/1695 (17%)
Query: 7065 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 7111
+ L+ L+K E + + N L + +++ E+ S V+S R+L + W
Sbjct: 311 EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
Query: 7112 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 7171
LDH + KI L L A+ + LM+ S S+ + ++ +Q ++
Sbjct: 371 DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
Query: 7172 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 7227
++L D E L +T + E H P+ N L+E+ R NN+LE+ +
Sbjct: 429 LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
Query: 7228 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 7283
E +L L K SK ++ + ELL +K I + E + T
Sbjct: 482 LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
Query: 7284 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
Q C ++ K L A I + + +C + +
Sbjct: 540 QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
Query: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
+++LQ + + T+ ++L L A E T +E ++E+ + L
Sbjct: 578 KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
Query: 7404 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 7457
++ + LNE G L ++ K ++ LN+ W + S+T + Q
Sbjct: 621 WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
Query: 7458 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 7513
Q + + + V+ ++VE+ NY ++ HE E + ++
Sbjct: 679 DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
Query: 7514 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7573
D ++L+ Q ++ W+ + + ++D Q M E
Sbjct: 738 ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
Query: 7574 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7633
L+ + + S +FDE+ + + L+ I + E+ + +L
Sbjct: 769 SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
Query: 7634 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7693
+ LQA++ E +EK + ++L K L + D + K + +S ++L ++
Sbjct: 810 T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
Query: 7694 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 7753
+ Q L ++ K E + S T L + + L ++ D L E+
Sbjct: 862 MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
Query: 7754 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 7813
+ +WE L H+LSL QQ+ + EK K L + + ++E ++++ ++
Sbjct: 919 SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
Query: 7814 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7872
+ L K++ E ++E + QL E L + E + + + ++ ++ ++ ++
Sbjct: 971 RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
Query: 7873 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7932
+ +K E + +Q S + E+ P +SE K + Q
Sbjct: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
Query: 7933 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 7990
++ +E +ASVL L E + + D A SI D +R+I +E
Sbjct: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
Query: 7991 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 8050
L+ + + D+S ED +SS A + VI K+FE ++
Sbjct: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
Query: 8051 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 8110
+ I K + R+ + L+ + N R ++L+ + +L
Sbjct: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
Query: 8111 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 8170
+ S+L+ +++ L I+ F D + L+ Q I+ ++ G
Sbjct: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
Query: 8171 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8230
++++ P D ++ + + + + + RV+R L
Sbjct: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
Query: 8231 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER-SGRDTPASVDSIPLEWDHDY 8289
AL D R+A LS +P ++LS S Q + + ++ + + + H
Sbjct: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD 1378
Query: 8290 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS-ALESQIRQLGKALDDSRFQ 8348
+ L+ + A +D ++ D + ++ LS H ++ + + K L+ F+
Sbjct: 1379 KCLKMLDMSFKDAERGDDTSCENLLDAF---SIKLSETHGYGVQEEFTEENKLLEACIFK 1435
Query: 8349 ----------IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 8398
+Q + I K PT P + K ++L +D + + L+E
Sbjct: 1436 NNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRL----DKVLDEYEEEKRHLQEMA 1491
Query: 8399 ESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELRMKQNLQKWQQFNSDLNSIW 8453
SLP F + + Q + WE L + L + R+ + L+++Q F S L +
Sbjct: 1492 NSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTT-- 1549
Query: 8454 AWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC--- 8505
L EE + LQ + L I IE+ ++ E + VD + ++
Sbjct: 1550 --LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607
Query: 8506 -----SPEFTQAD----------SKESRDLQDRLSQMNGRWDRVCSL---LEEWRGLLQD 8547
P F + ++++ D + L + WD++ +L ++EW +
Sbjct: 1608 MKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW----TE 1663
Query: 8548 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQL 8607
+Q H+++ E+ +R K E+ + + + +++ +I+ L S++
Sbjct: 1664 KALQKMELHQLTE------EDRERLKEEL-----QVHEQKTSEFSRRVAEIQFLLQSSEI 1712
Query: 8608 RVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKLLLKEVSRHIKELEKLLDVS 8663
+ LQ M +L E CL + H + L+ L + I E LL
Sbjct: 1713 PL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKAL 1771
Query: 8664 SSQQDLSSWSSADEL 8678
S L ++ +E+
Sbjct: 1772 SPSDSLEIFTKLEEI 1786
Score = 57.8 bits (138), Expect = 5e-07
Identities = 88/534 (16%), Positives = 217/534 (40%), Gaps = 51/534 (9%)
Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
+ + GE+ L +++ + + + ++ L++ W D+ +S + W+ ++
Sbjct: 5760 LTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKI 5819
Query: 2743 NQLEQWMESVDQKIEHPL-QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY 2801
+L+ ++ + + E PL + L + L+ L+ L+ + + L + A +
Sbjct: 5820 KELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTR-H 5878
Query: 2802 EKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKE 2861
ED E L Q+ D+ + +++E+ + +++ + E WL +
Sbjct: 5879 VLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMEN 5938
Query: 2862 ELHRWSDMSGDSSATQKKLSKI-KELIDSREIGASRLSRVESLAPEVKQNTTASGCELMH 2920
++ + +D+S ++ + K+ K+ ++ + + +++ + ++ + + S +
Sbjct: 5939 KVLQTADIS-----IEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEID 5993
Query: 2921 TEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWA 2980
++ + W+ D + S ++ L A +Q L++ + L+TW
Sbjct: 5994 DKLNKINDRWQHLFDVI---GSRVKKLKETFAFIQQ------------LDKNMSNLRTWL 6038
Query: 2981 QQLTLLEGKNT------DEEIVECWHKGQEILDALQKAEPRTE------DLKSQLNELCR 3028
++ K D+EI + + Q++ +++ E D+ ++ C
Sbjct: 6039 ARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACA 6098
Query: 3029 FSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQI--LQQRFRKAFRDFQQWLVNAKIT 3086
+ + L + + +C + + E+ L Q+F + F+ WL +A+
Sbjct: 6099 NETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAE-R 6157
Query: 3087 TAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTK-------EK 3139
TA C N SEV + K E L E Q +++ L++ EL++ + +
Sbjct: 6158 TAAC----PNSSEVLYTSAK--EELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDT 6211
Query: 3140 AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTE 3193
A ++ V + W N + L + Q ++FE + E I WL++ +
Sbjct: 6212 ASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
Score = 41.2 bits (95), Expect = 0.046
Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)
Query: 8421 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8480
W LQ + L K L+ +N ++++NS L+ + ++ EE+ L L + D+ ++
Sbjct: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
Query: 8481 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 8536
+L+E +DH+ A + +N P T+A +E +L D + + +
Sbjct: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
Query: 8537 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8596
L++E L + + + E +LL EN D +VP
Sbjct: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
Query: 8597 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 8644
++L E + R+ ++ + LL+ CL E K K+ + G+R ++L
Sbjct: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
Query: 8645 LLKEVSRHIKELEKLLDVSSSQQ 8667
LL++ + I+E E L + +S Q
Sbjct: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
Score = 39.3 bits (90), Expect = 0.17
Identities = 89/494 (18%), Positives = 194/494 (39%), Gaps = 55/494 (11%)
Query: 316 DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRK-QIEHLIQPLHR 374
++ + KE++ + + ++L Q ++++L +H V+ M K QIEHL HR
Sbjct: 5847 EKELIKELEQSLASWTQNLKELQTMKADLT------RHVLVEDVMVLKEQIEHL----HR 5896
Query: 375 DGK-LSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAE--VALREEITV 431
+ L L A+ KQ + RL W + +K+ + AWL + E V +I++
Sbjct: 5897 QWEDLCLRVAIRKQE---IEDRLNTWVVFNEKNKE-----LCAWLVQMENKVLQTADISI 5948
Query: 432 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 491
+++ E+ ++ + N K+ ++ + + + D+L + +R+
Sbjct: 5949 EEMIEKLQKDCMEEINLFSE---NKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005
Query: 492 VSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---------EQLLQN 542
+ + K L+ + + L S L++W+ + S +++ +
Sbjct: 6006 LFDVIGSRVKK---LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKR 6062
Query: 543 YVSFIENSKFFEQYEVTYQILKQTAEMYVK---ADGSVEEAENVMKFMNETTAQWRNLSV 599
+ + EQ+ + + ++ + A + E +++ + +WRN+
Sbjct: 6063 LAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122
Query: 600 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML---NQSE----NAKKD------F 646
R +EE W ++ + + + WL+ AE+ N SE +AK++ F
Sbjct: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182
Query: 647 FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ-YAQADE 705
R + + Q +N L + LKQ + N RW L V +
Sbjct: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
Query: 706 MDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY-K 764
++E+ ++ + TE +L+ S + ++ L +Q + + + +
Sbjct: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
Query: 765 IITKTAHLITKESP 778
+I LI K P
Sbjct: 6303 LIVFGEQLIQKSEP 6316
Score = 35.4 bits (80), Expect = 2.5
Identities = 26/121 (21%), Positives = 55/121 (45%), Gaps = 6/121 (4%)
Query: 1444 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1498
+K S+ ++ W+ + E EL L+ + D+Q +++V +QEI ++ +
Sbjct: 6549 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 6608
Query: 1499 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFE 1558
+V + ++ F Q + ES ++++L Q+ E + G + L Q Q F
Sbjct: 6609 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFH 6667
Query: 1559 E 1559
+
Sbjct: 6668 Q 6668
>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform 3
[Homo sapiens]
Length = 982
Score = 1890 bits (4895), Expect = 0.0
Identities = 959/982 (97%), Positives = 959/982 (97%), Gaps = 23/982 (2%)
Query: 7839 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 7898
MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR
Sbjct: 1 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
Query: 7899 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 7958
TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD
Sbjct: 61 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 7959 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 8018
ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
Query: 8019 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 8078
ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL
Sbjct: 181 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
Query: 8079 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 8138
KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS
Sbjct: 241 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
Query: 8139 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8198
ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE
Sbjct: 301 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
Query: 8199 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 8258
VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS
Sbjct: 361 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
Query: 8259 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 8318
LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL
Sbjct: 421 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
Query: 8319 RGAVGL-----------------------SGDHSALESQIRQLGKALDDSRFQIQQTENI 8355
RGAVGL SGDHSALESQIRQLGKALDDSRFQIQQTENI
Sbjct: 481 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 540
Query: 8356 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 8415
IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA
Sbjct: 541 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 600
Query: 8416 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 8475
GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI
Sbjct: 601 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660
Query: 8476 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8535
QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC
Sbjct: 661 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720
Query: 8536 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8595
SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL
Sbjct: 721 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
Query: 8596 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8655
MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE
Sbjct: 781 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
Query: 8656 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8715
LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP
Sbjct: 841 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 900
Query: 8716 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 8775
HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA
Sbjct: 901 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 960
Query: 8776 LSNNFARSFHPMLRYTNGPPPL 8797
LSNNFARSFHPMLRYTNGPPPL
Sbjct: 961 LSNNFARSFHPMLRYTNGPPPL 982
Score = 77.4 bits (189), Expect = 6e-13
Identities = 136/853 (15%), Positives = 335/853 (39%), Gaps = 71/853 (8%)
Query: 3572 LESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS-PRTRRQSN 3630
L + WQ ++ + + ++ +++ + WL E +++ P N
Sbjct: 21 LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCN 80
Query: 3631 RATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMG-CQATQ-----LTS 3684
+ +L++ ++ ++ + V V + +L + + C + Q L
Sbjct: 81 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 140
Query: 3685 RYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMG 3744
R++ + +E+ +EE + ++ S + DW S+ + ++ V +
Sbjct: 141 RWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS--GVIYTVAK 198
Query: 3745 KKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV 3804
++LK E + + + + L+ ++ R + A L++ +H+ ++ L V
Sbjct: 199 EELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV 258
Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
L+ + +EF ++ W+ E L + + +A++ + K+ QQ
Sbjct: 259 TSILRRLKHFIGQREEFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQ 316
Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT---LKDKIDQLQSDYQDLCS-IGKEHVFSLEAK 3920
+ + ++ + +GE L+E + + +++++D+L+ Q++ + + H +
Sbjct: 317 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 376
Query: 3921 VKDHE----DYNSELQEVEK-----WLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME 3971
+ D E D EL++ W + + L++P SL ++ Q L ++ +
Sbjct: 377 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL-SLAQPLRSERSGRD 435
Query: 3972 EIAGFE------DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQ 4025
A + D +L ++ + + + + + +L+G + +
Sbjct: 436 TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 495
Query: 4026 RMYQSLEHELQKHVS----------RQ------DTLQQCQAWLSAVQPDLEPSPQPPLSR 4069
Y L K+ S RQ D+ Q Q + ++ P+ S
Sbjct: 496 EAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSY 555
Query: 4070 -------AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QTI 4118
E + + L+ + + + L +L + +T A I + E Q +
Sbjct: 556 KGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT-AGVIDRWELLQAQAL 614
Query: 4119 EQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
++L QNL Q W++ + +W +L D +++L+ ++R ++ + + ++K+
Sbjct: 615 SKELRMKQNL-QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKEL 673
Query: 4179 VKKLQSKQA---SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREED 4235
K + ++A S+N + + KE ++ +N +W +C ++
Sbjct: 674 QKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDA 733
Query: 4236 LQRTRDYHDCMNVVEVFLEKFTTEWDNL----ARSDAESTAVHLEALKKLALALQERKYA 4291
L + + +H+ + + + LE + + + DAE H + L ++ L E +
Sbjct: 734 LMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR 793
Query: 4292 IEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQS 4351
+ L+D +++ + D KE+ + R L+ +++ + LE+L V S
Sbjct: 794 VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL----KLLLKEVSRHIKELEKLLDVSS 849
Query: 4352 RFQELMEWAEEQQ 4364
Q+L W+ +
Sbjct: 850 SQQDLSSWSSADE 862
Score = 73.9 bits (180), Expect = 6e-12
Identities = 156/844 (18%), Positives = 338/844 (40%), Gaps = 70/844 (8%)
Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICS-SATETYKVLQEHMDLCQALESLSSAITAFS 1613
Q+ ++N+ ++ ++ E +LA PI S ++ E + L E +L + +E S+ + +
Sbjct: 50 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 109
Query: 1614 ASARKVVNR-DSCVQEAAA---------LQQQYEDILRRAKERQTALENLLAHWQRLEKE 1663
+++ D+C +A L +++ +I + ER+ +E WQ+ +
Sbjct: 110 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 169
Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
S F WL+ E A+ P V E EL+ +A Q +V + + + L
Sbjct: 170 YSRFEDWLKSSERTAAFPSSSGVIYTVAKE-ELKKFEAFQRQVHECLTQLELINKQYRRL 228
Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
D +K + + ++RW +L + + + L+ + + ++F+ S VW+
Sbjct: 229 ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTE 288
Query: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
+L S D Q + + K E+ +++ + +L D +++
Sbjct: 289 MDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348
Query: 1844 GKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESD 1903
+ ++ + +E VER L L H + ++ + E
Sbjct: 349 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH--------------DLSDRELELEDS 394
Query: 1904 LIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQ 1963
DL+ ++A +L S S + LS AQ + S A+ D + E +
Sbjct: 395 AALSDLHWHDRSADSLLSPQPSSNLSLSLAQ---PLRSERSGRDTPASVDSIPLEWDHDY 451
Query: 1964 NLLGTKQSE-ADALAVLKKAFQDQKEELLK---SIEDIEERTDKERLKEPTRQALQQRLR 2019
+L +S + AL + QD K+ L+ + D+ E + T A++
Sbjct: 452 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 511
Query: 2020 VFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQG 2079
+ LE ++ L D QI Q + + L+ ++ +L+ G
Sbjct: 512 DHSALESQIRQLGKA---LDDSRFQIQQTENIIRSKTPTG-PELDTSYKGYMKLL----G 563
Query: 2080 QCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQ 2139
+C ID ++ ++ + L ++ T T D +W + + ++ KQ
Sbjct: 564 ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID-RWELLQAQALSKELRMKQ 622
Query: 2140 ---------KDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMD 2190
DL++ + EL+++ + S +E + K L +K ++
Sbjct: 623 NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKK-LKELQKAVDHRK 681
Query: 2191 RLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALR 2250
+ +S+++ + D E S + ++++ D R LL+E+ +++ ++
Sbjct: 682 AIILSINLCSPEFTQADSKE--SRDLQDRLSQMNGRWD---RVCSLLEEWRGLLQDALMQ 736
Query: 2251 LEELHSKVNDLKELTKNL-----ETPPDLQFIEADLMQKLEHAKEIT----EVAKGTLKD 2301
+ H + L + +N+ E P ++A+++Q +H K++ E+ + L+
Sbjct: 737 CQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ--DHHKQLMQIKHELLESQLRV 794
Query: 2302 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQE 2361
+ Q + +N T + +E ++ N LK+V KEL+ + ++SS+Q+
Sbjct: 795 ASLQDMSCQLLVNAEGTDCLEAKEK-VHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQ 852
Query: 2362 NLNS 2365
+L+S
Sbjct: 853 DLSS 856
Score = 72.0 bits (175), Expect = 2e-11
Identities = 60/358 (16%), Positives = 149/358 (41%), Gaps = 17/358 (4%)
Query: 7628 GKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE 7687
G++L ++ + ++ +L ++ ++W+ + + KKL L ++ +K ++
Sbjct: 2 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 7688 KLRTFKKKLSQSL-------PDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 7740
L + +L++ + + +L+ +Q +++E L +L A
Sbjct: 62 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 7741 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 7800
+ + + + L R+W +C RR +I E W F + +WL E
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
Query: 7801 SKVS--QNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIE 7856
+ + ++ E+LKK +Q ++ + + RLA+ + A ++
Sbjct: 182 RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK 241
Query: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 7916
+ + N RW +L + + +++LK + ++ + S+ WL ++ +L +
Sbjct: 242 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 301
Query: 7917 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL---HDCDACATDAECDSIQQ 7971
C ++Q K+ + + Q++I + + ++ E L+ DA + E D +++
Sbjct: 302 C---DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
Score = 71.2 bits (173), Expect = 4e-11
Identities = 150/846 (17%), Positives = 321/846 (37%), Gaps = 109/846 (12%)
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECW--HKGQEILDALQKAEPRTEDLKSQL 3023
+ L+ +A +K + L ++ + + + W H E+ + +E+++ +L
Sbjct: 29 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKL 88
Query: 3024 NELCRFSRDLSTYSGKVSGLIKE-----YNCLCLQASKGCQNKEQI-------------- 3064
NE RD+ +S V+ ++ ++C C + +Q
Sbjct: 89 NEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAM 148
Query: 3065 -------------LQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFL 3111
L Q+F + F+ WL +++ T A + L+K + F
Sbjct: 149 SMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQ 208
Query: 3112 SESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENL 3171
+ +L ++ + L+ + A ++ V + W N + L++
Sbjct: 209 RQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHF 268
Query: 3172 KIQMKDFEVSAEPIQDWLSKTE-KMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQL 3230
Q ++FE + + I WL++ + ++ + D+ AK ++ + Q +EI ++
Sbjct: 269 IGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ---QEISLNHNKI 325
Query: 3231 NRLKEKAQQLWEGQAASKS--FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLG 3288
++ + +QL E + + +L + + +L R+ ++ L
Sbjct: 326 EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLS 385
Query: 3289 IKELQDWMTDAIHMLDSYCHPTSDKSVLDSR-TLKLEALLSVKQEKEIQMKMIVTRGESV 3347
+EL+ + D+ + D + H S S+L + + L L+ E + +S+
Sbjct: 386 DRELE--LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSI 443
Query: 3348 -------------LQNTSPEGIPTIQQQLQSVKDMW----ASLLSAGIR---------CK 3381
L++ +P+ ++ Q KD + L I +
Sbjct: 444 PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
Query: 3382 SQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKT--------TMLGKAK 3433
+ ++ ++ + +RQ +D + ++E +R KT + G K
Sbjct: 504 NAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI---IRSKTPTGPELDTSYKGYMK 560
Query: 3434 LLNEEVLSYSSL------LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487
LL E S S+ L+ E G + T+ + + +R+ +Q +A +
Sbjct: 561 LLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRM 620
Query: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE--GDAHTHETTLRDLQELQVHCAEG 3545
++ ++ Q++ DL + WLG +E+L+Q LE D T E ++ L+ELQ
Sbjct: 621 KQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHR 680
Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3605
+A++ S+ + + E R L+ R+ ++ ++ + Q
Sbjct: 681 KAIILSINLCSPEFTQA--DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 738
Query: 3606 KFQQVDEWLKTAEEKVSPRTRR----QSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGAR 3661
F ++ L E + R SN + +Q H H+++ + E+ E R
Sbjct: 739 GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH-----HKQLMQIKHELLESQLR 793
Query: 3662 AQEILDES---HVNSR-MGCQATQ-----LTSRYQALLLQVLEQIKFLEEEIQSLEESES 3712
+ D S VN+ C + + +R + LL +V IK L E++ + S+
Sbjct: 794 VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL-EKLLDVSSSQQ 852
Query: 3713 SLSSYS 3718
LSS+S
Sbjct: 853 DLSSWS 858
Score = 70.1 bits (170), Expect = 9e-11
Identities = 153/829 (18%), Positives = 321/829 (38%), Gaps = 94/829 (11%)
Query: 7196 QLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTV 7255
+L K H + L +VN RW +LL+ IA +++ K L Q+ K +S
Sbjct: 4 RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ---LDKNMSSLR 60
Query: 7256 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 7315
+EL K +E+ + + +L + + + + L E L D
Sbjct: 61 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 7316 ASAASA----IQSDQLSLS---QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 7368
A A A IQ +L +++CA+ +++ ++ ++ F E W+
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAMSM---ERRLKIEETWRLWQKFLDDYSRFEDWL 177
Query: 7369 VEAEEILQGQDPSHSSDLSTI-QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-- 7425
+E PS S + T+ +E +++ + + L+ +N+ RL ++
Sbjct: 178 KSSER--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
Query: 7426 ---EIKRM-QNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 7481
+K+M N+ W + + T +L+ F+ Q + F ++ + +L + + +L
Sbjct: 236 SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT- 294
Query: 7482 EISGNYQHLLE---QQRAHEL--FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 7536
N +H E Q + +L FQ E+ + II G++L+E+ + D +
Sbjct: 295 ----NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
Query: 7537 LTLLSNQWQGVIRRAQQ------RRGIIDSQIRQWQRYREMAEKL---------RKWLVE 7581
L L Q V R ++ R + D + R E+ + R
Sbjct: 351 LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410
Query: 7582 VSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAE 7640
+S P S L S+ PL+ R+ D + + L Y L+ + + + S E
Sbjct: 411 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470
Query: 7641 AALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE-KLRTFKKKLSQS 7699
+ ++ + + + E + L ++ K G +LE ++R K L S
Sbjct: 471 EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530
Query: 7700 LPDHHEELHAEQMRCKELENAVGSWTD-----DLTQLSLLKDTLSAYISADDISILNERV 7754
+ + ++ EN + S T D + +K S D + L ++
Sbjct: 531 -----------RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 579
Query: 7755 ELLQR--------------------QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCE 7794
+ + +WE L Q + ++ + L +W F+ +
Sbjct: 580 KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
Query: 7795 WLTQMESKVSQ------NGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 7848
WL E ++ Q + DI E+ K K+ Q+ + + + + +A
Sbjct: 640 WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD- 698
Query: 7849 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 7908
++ +++ +L ++N RW + L+ L++ L+ Q + L L +I+
Sbjct: 699 SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 758
Query: 7909 AKPIVYDS-CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL-CEVLLH 7955
+ + DS ++E +Q + +++ ++ + VAS+ ++ C++L++
Sbjct: 759 NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 807
Score = 65.5 bits (158), Expect = 2e-09
Identities = 129/808 (15%), Positives = 321/808 (39%), Gaps = 88/808 (10%)
Query: 2273 DLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLM---- 2328
++++ + + +H ++ LK+ Q++K ++ + TW +E L
Sbjct: 16 EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
Query: 2329 --NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS----AELESLGRAM 2382
+C E L + +++Q++++ + ++S L + AE +S+ +A
Sbjct: 76 YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135
Query: 2383 TGLIKKHEAVSQLCSKTQASLQES--LEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSK 2440
L ++ + + + + ++E+ L + F + F++W ++ A S
Sbjct: 136 RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 195
Query: 2441 VLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFL 2500
V + +L + V + ++L+ + ++ + L S+++ + + N+ +
Sbjct: 196 VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQ 255
Query: 2501 KQCLKDKQALQDCASELGSFEDQHRKLNLWIHEME-ERFNTENLGESKQHIPEKKNEVHK 2559
K+ + L+ + FE + +W+ EM+ + N E+ E + + ++ +
Sbjct: 256 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC-----DVQAKIKQ 310
Query: 2560 VEMFLGELLAARESLDKLSQRGQLLSEEG---------HGAGQEGRLCSQLL----TSHQ 2606
++ F E+ ++++ +G+ L E+ + R C ++ H+
Sbjct: 311 LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370
Query: 2607 NLLRM----TKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
L+R+ + L ++ L++ AL + W D L + + +L +
Sbjct: 371 KLIRLPLPDDEHDLSDRELELEDSAALSDL-----HWHDRSADSLLSPQPSSNLSLSLAQ 425
Query: 2663 RLSQIQ---------DILLMKGEGEVKLNMAIGKG-EQALRSSNKEGQRVIQTQLETLKE 2712
L + D + ++ + + L+ + +AL S ++EGQ L
Sbjct: 426 PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVG 485
Query: 2713 VWADIM---SSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD------QKIEHPLQPQ 2763
+ +D+M S + + T ++ + D+ ++Q+ Q +++D Q+ E+ ++ +
Sbjct: 486 L-SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSK 544
Query: 2764 -PGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKT--- 2819
P E +L E ++ RL K +E E+ F + E +T
Sbjct: 545 TPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKE--EEESLPGFVNLHSTETQTAGV 602
Query: 2820 --QFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWS--DMSGDSSA 2875
++ + A K ++++ ++ + ++ WL +EEL + ++S D
Sbjct: 603 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 662
Query: 2876 TQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWED 2935
+ ++ K+KEL + + + + + +PE Q + +L + + W +
Sbjct: 663 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQMNGRWDRVCS 721
Query: 2936 SVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEI 2995
+ + + L++ + Q + G + LE + + ++ N D EI
Sbjct: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPI---------DSNLDAEI 772
Query: 2996 VECWHKGQEILDALQKAEPRTEDLKSQL 3023
++ HK Q + + E L+SQL
Sbjct: 773 LQDHHK--------QLMQIKHELLESQL 792
Score = 62.0 bits (149), Expect = 3e-08
Identities = 152/818 (18%), Positives = 313/818 (38%), Gaps = 116/818 (14%)
Query: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822
S++E +L ++ + W + ++ + +L+ L + + L WL + L
Sbjct: 15 SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL---A 71
Query: 6823 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATL 6877
+ V E ++ LN E ++++ S+ +SVL+ LL + ++
Sbjct: 72 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
+ +D +W ++ + K+ + S W+ E +
Sbjct: 132 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS- 190
Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
+ Y E L+K++ F+ ++ ++ +N+ +++ R ++TD A L
Sbjct: 191 --GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACSLK 241
Query: 6998 AM----NKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 7053
M N+ W LQ VT ++ L+ + E+E + W + +L
Sbjct: 242 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF-S 300
Query: 7054 QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN 7113
+ VQ +K + + I ++E+I G LI+ + ++I+ L EL +
Sbjct: 301 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
Query: 7114 L-------------------DHMVGQLKILLK--SVLDQWSSHKVAFDKINSYLMEARYS 7152
+ +H + ++ L+ + L H + D + S + S
Sbjct: 361 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
Query: 7153 LSRFRLL---------TGSLEAVQVQVDNLQNLQDDLEK----------------QERSL 7187
LS + L S++++ ++ D+ +L DLE ++ L
Sbjct: 421 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
Query: 7188 QKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 7247
+ +++ ++ E + N +K + + L +I Q KAL D
Sbjct: 481 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR---QLGKAL--------DD 529
Query: 7248 SKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 7307
S+ +QQ E+ K T ++ D +++ + + +VK L E
Sbjct: 530 SR---FQIQQTENIIRS--KTPTGPEL-DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
Query: 7308 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 7367
E L V+ + + + + L A QAL K + ++ + ++ F L ++ AW
Sbjct: 584 ESLPGFVNLHSTETQTAGVIDRWELLQA--QALSK-ELRMKQNLQKWQQFNSDLNSIWAW 640
Query: 7368 IVEAEEIL-QGQDPSHSSDLSTIQERMEEL----------KGQMLKFSSMAPDLDRLNEL 7416
+ + EE L Q Q S+D+ TI+ ++++L K +L + +P+ + +
Sbjct: 641 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
Query: 7417 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF----------LEKCE 7466
R L D R+ +N W + S E LQ L+Q Q F LE +
Sbjct: 701 ESR-DLQD----RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
Query: 7467 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEM 7504
+V + L EI ++ L Q + HEL ++++
Sbjct: 756 RRKNEIVPIDSNLDAEILQDHHKQLMQIK-HELLESQL 792
Score = 61.2 bits (147), Expect = 4e-08
Identities = 149/812 (18%), Positives = 306/812 (37%), Gaps = 114/812 (14%)
Query: 3463 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3522
+ +L + +R++ + + V K ++ + Q+ +++ + WL + +L + V +
Sbjct: 18 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 77
Query: 3523 G-DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQD--- 3578
++ + L + QELQ + + SVL+ E ++ A D +S++Q
Sbjct: 78 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 137
Query: 3579 ----WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS-PRTRRQSNRAT 3633
W+ E R + + + + ++WLK++E + P +
Sbjct: 138 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 197
Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT----SRYQAL 3689
KE +L + + + +V ++E + + + + E+ +S C Q+ R+ L
Sbjct: 198 KE-ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS--ACSLKQMVHEGNQRWDNL 254
Query: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749
+V ++ L+ I EE E++ S W N I+ + K+K
Sbjct: 255 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN----IEHFSECDVQAKIKQ 310
Query: 3750 LEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHM 3809
L+ +++ H+ ++ +GE+ ++ E +A + +E+ + +E+ V + H
Sbjct: 311 LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370
Query: 3810 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH 3869
L + E + L + LH + L + + SL Q + S
Sbjct: 371 KLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 430
Query: 3870 E------PSVKSVREKGEALLELVQD--------VTLKDKIDQLQSDYQDLCSIGKEHVF 3915
SV S+ + + +L +D + +D+ Q D+ ++G V
Sbjct: 431 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 490
Query: 3916 ---SLEAKVK-----------DHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
S EA VK DH S+++++ K L ++ + + S T +
Sbjct: 491 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 550
Query: 3962 QLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCAD------HLQAKLKQ---------NV 4006
+K M+ L+G+C+ L+ KLK+ N+
Sbjct: 551 LDTSYKGYMK------------------LLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
Query: 4007 HA---HLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSP 4063
H+ G D + + + A ++ LQK L AWL + +LE
Sbjct: 593 HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
Query: 4064 QPPLSR-AEAIK-QVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4121
+ LS + I+ Q+K + LQ+ ++ S+ S + +K+ + + + Q
Sbjct: 653 RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQ- 711
Query: 4122 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQ--------------LQNMKRRHSE----- 4162
+ W+ + L E LQDA Q L+N+ RR +E
Sbjct: 712 ------MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 765
Query: 4163 --LELNIAQNMVSQVKDFVKKLQSKQASVNTI 4192
L+ I Q+ Q+ +L Q V ++
Sbjct: 766 SNLDAEILQDHHKQLMQIKHELLESQLRVASL 797
Score = 59.7 bits (143), Expect = 1e-07
Identities = 127/696 (18%), Positives = 276/696 (39%), Gaps = 67/696 (9%)
Query: 7518 GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRK 7577
G+RL + E KL ++++WQ ++ R + + Q+ + LR
Sbjct: 2 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 7578 WLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADS 7637
WL + + ++ + +E Q ++ + + + LL D+
Sbjct: 62 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 7638 GAEAA----LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7693
A A +Q + +W++ E++ K+ + W+K + + L++ +
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
Query: 7694 KKLSQSLPDHHEELHA-EQMRCKELENAVGSWTDDLTQLSLLKDT---LSAYISADDISI 7749
+ + + P ++ + K+ E + LTQL L+ L+ D
Sbjct: 182 R--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
Query: 7750 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQN 7806
L + V ++W+ L +++ +++ + + F + WLT+M+ + +
Sbjct: 240 LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 299
Query: 7807 GDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
+ ++ I++LK +Q+EI++ Q+ GE+L + S A+ IE +L ++
Sbjct: 300 SECDVQAKIKQLKA-FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 358
Query: 7867 QHLLDLIAARVKKL------------------KETLVAVQQL---DKNMSSLRT--WLAH 7903
Q + + KKL E A+ L D++ SL + ++
Sbjct: 359 QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
Query: 7904 IESELAKPIVYD------SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 7957
+ LA+P+ + + + I + + +L RD+E S ++ + E D
Sbjct: 419 LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE--SAMSRALPSEDEEGQDDK 476
Query: 7958 DACATDAECDS---IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 8014
D A S I ++ + N + +E R K LDD SRF+
Sbjct: 477 DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDD-SRFQ-- 533
Query: 8015 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT-- 8072
++ +E + +G E ++ + + + EC + ++ + + +L E +
Sbjct: 534 IQQTENIIRSKTPTG------PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 587
Query: 8073 --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 8130
+ S + RW+ LQ + S R+K + + ++F + +SI WL + + +
Sbjct: 588 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 647
Query: 8131 LTNIEHFS-ECDVQA---KIKQLKAFQQEISLNHNK 8162
L ++ D+Q +IK+LK Q+ +++H K
Sbjct: 648 LEQLQRLELSTDIQTIELQIKKLKELQK--AVDHRK 681
Score = 58.5 bits (140), Expect = 3e-07
Identities = 163/931 (17%), Positives = 353/931 (37%), Gaps = 144/931 (15%)
Query: 5070 DLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
++E K+ + R Q + A+V L+ K + + E +L++ +
Sbjct: 16 EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL----EEKASQLEKTGNDASKATLSRSM 5185
+ +S E + KL+E + L + + ++ E + DA ++ ++
Sbjct: 76 YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135
Query: 5186 TTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKA 5245
+ +RW + A++ ++ +E+ W F + + + + + S+
Sbjct: 136 RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 195
Query: 5246 ELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCL 5305
L+ + F ++ + + L ++ +Q + ++ + L Q + R
Sbjct: 196 VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS---LKQMVHEGNQRWD 252
Query: 5306 NMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN----PTIEIDAQLEELQ 5361
N+Q++V + + +K + RE ET +S+ W+ E L N ++ A++++L+
Sbjct: 253 NLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK 312
Query: 5362 ILLTEATNHRQNIEKM------------------------------------AEEQKEKY 5385
E + + IE++ E +K
Sbjct: 313 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 372
Query: 5386 LGL------YTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQK--- 5436
+ L + + EL L+ + DL D+ D + + S S L++ ++
Sbjct: 373 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 432
Query: 5437 --------------------LAKDLTTILTKLKAKTDNVVQAKTD---------QKVLGE 5467
L++DL + +++ D Q D V+
Sbjct: 433 GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIP 492
Query: 5468 ELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAAS 5527
E KL E A++ + L + +++GK + + I+Q EN +
Sbjct: 493 ESPEAYVKLTE--NAIKNTSGDHSALESQI-RQLGKALDDSRFQIQQTENIIRSKTPTGP 549
Query: 5528 HLEE----YNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS-- 5581
L+ Y ++L I+ K L H L LH T + + ID
Sbjct: 550 ELDTSYKGYMKLLGECSSSIDSVKRLEHK--LKEEEESLPGFVNLHSTETQTAGVIDRWE 607
Query: 5582 --ELEAMTEKLQYLTSVYCTEKMSQQV----AELGRETEELRQMIKIRLQ-NLQDAAKDM 5634
+ +A++++L+ ++ ++ + + A LG EEL Q+ ++ L ++Q +
Sbjct: 608 LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667
Query: 5635 KKFEAELKKLQAALEQAQA-----TLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV 5689
KK LK+LQ A++ +A L SPE + KE Q LS+M +V
Sbjct: 668 KK----LKELQKAVDHRKAIILSINLCSPEFTQADSKES-RDLQDRLSQMNGRWDRV--C 720
Query: 5690 QLCQSALRIPEDVVASL----PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 5745
L + + +D + + H L + E R ++ + + + A ++Q
Sbjct: 721 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ------ 774
Query: 5746 EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKML 5805
H +QL++ H E+ + + +++Q++ Q+ + E ++ +E++ + ++ K+L
Sbjct: 775 --DHHKQLMQIKH-ELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLL 830
Query: 5806 TMK-AKHATMLLTVTEVEGLAEGTE--------DLDGELLPTPS-AHPSVVMMTAGRCH- 5854
+ ++H L + +V + D G + PT + P+ G+C
Sbjct: 831 LKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSL 890
Query: 5855 ----TLLSPVTEESGEEGTNSEISSPPACRS 5881
+S S + G++S +S P RS
Sbjct: 891 SQPGPSVSSPHSRSTKGGSDSSLSEPGPGRS 921
Score = 58.2 bits (139), Expect = 4e-07
Identities = 181/887 (20%), Positives = 351/887 (39%), Gaps = 150/887 (16%)
Query: 1191 LTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELIS 1250
L + S E++A + +L K++ ++ L+ L++ K L VQ + +SL ++
Sbjct: 5 LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 64
Query: 1251 GSKEVQEQAEK--ILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQ----QGEG 1304
++ + K + D+ N E Q+ L Q+ + I V + + +
Sbjct: 65 ---HIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 1305 GLPDRGHEELRKLESTLDGLERS--RERQERRIQV--TLRKWERFETNKETVVRYLFQTG 1360
D + +++ LD R+ ERR+++ T R W++F + +L
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL---- 177
Query: 1361 SSHERFLSFSSLESL-----SSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL 1415
S ER +F S + EL++ + F ++ Q E + K+ L +N+
Sbjct: 178 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRR--LARENRT- 234
Query: 1416 LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHF---GSNFET----LSVWITEKEKE 1468
A S+K+ V + + K + + + HF FET + VW+TE + +
Sbjct: 235 --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 292
Query: 1469 LNALETSSSA-MDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527
L +E S + +I Q+K QEI + I + + + + ++A I+ +L
Sbjct: 293 LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELD 352
Query: 1528 QIRRYGEEL-----REHAQCL-------------------EGTILGHLSQQQKFEENLRK 1563
++RRY +E+ R H + + + L L + ++L
Sbjct: 353 ELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS 412
Query: 1564 IQQSVSEFEDKLAVPIKICSSATETYKVL-------QEHMDLCQALES-LSSAITAFSAS 1615
Q S S LA P++ S +T + DL + LES +S A+ +
Sbjct: 413 PQPS-SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471
Query: 1616 ARKVVNRDSCVQEAAALQ------------QQYEDILRRAKERQTALENLLAHWQRLEKE 1663
+ ++D ++ A L + E+ ++ +ALE+ + ++L K
Sbjct: 472 GQD--DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQI---RQLGKA 526
Query: 1664 LSSFLTWLERGE-----AKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQ 1718
L +++ E + PE+D S +G ++L+ + + S KL +
Sbjct: 527 LDDSRFQIQQTENIIRSKTPTGPELDTS-----YKGYMKLLGECSSSIDSVKRLEHKLKE 581
Query: 1719 LKESLFSVASKDDVKMMKLHLEQLDERWRDL-PQIINKRINFLQSVVAEHQQFDELLLSF 1777
+ESL ++ + + +RW L Q ++K + Q+ + + QQF+ L S
Sbjct: 582 EEESLPGFV---NLHSTETQTAGVIDRWELLQAQALSKELRMKQN-LQKWQQFNSDLNSI 637
Query: 1778 SVWI------KLFLSELQTTSEISIMDHQV----ALTRHKDHAAEV------------ES 1815
W+ L L+ +++I ++ Q+ L + DH + ++
Sbjct: 638 WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA 697
Query: 1816 KKGELQSLQGHLAKL-GSLGRAEDL-----HLLQGKAEDCFQLFEEAS-------QVVER 1862
E + LQ L+++ G R L LLQ C Q F E S + ++R
Sbjct: 698 DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC-QGFHEMSHGLLLMLENIDR 756
Query: 1863 RQLALSHL-----AEFLQS-HASLSGILRQLRQTVEATNSMNKNESD-LIEKDLNDALQN 1915
R+ + + AE LQ H L I +L ++ S+ L+ + D L+
Sbjct: 757 RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA 816
Query: 1916 AKALESAAVSLDGILSKAQYHLK-------IGSSEQRTSCRATADQL 1955
+ + L +L + H+K + SS+Q S ++AD+L
Sbjct: 817 KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 863
Score = 58.2 bits (139), Expect = 4e-07
Identities = 139/794 (17%), Positives = 312/794 (39%), Gaps = 85/794 (10%)
Query: 6559 ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVS 6618
+L K+ D + L+ +I +R L + L Q ++ + L L + ++A
Sbjct: 20 KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
Query: 6619 SKEEIQQLLDKHKEYFQGLESH-------MILTETLFRKIISFAVQKE----TQFHTELM 6667
+ EEIQ+ L++ +E + +E H + L E L + A E Q L
Sbjct: 80 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
Query: 6668 AQASAVLKRAHKRGVELEYILETW-SHLD-----EDQQELSRQLEVVESSIPSVGLVEEN 6721
+ + + +R +++E W LD ED + S + SS + V +
Sbjct: 140 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
Query: 6722 EDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTN 6781
E + + H + E K Y+ L R + S L+ +++ + W +
Sbjct: 200 ELKKFEAFQRQVHECLTQLELINKQYRRLARENR---TDSACSLKQMVHEGNQRWDNLQK 256
Query: 6782 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 6841
+++ L RL+ + +++ ++ WL +L ++ E + V+ +
Sbjct: 257 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-----TNIEHFSECD-VQAKIKQ 310
Query: 6842 FLEFSKEVDAQSSLKSSVLSTGNQLL-RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE 6900
F +E+ + +++ G QL+ + + +D A + EL + ++ + +
Sbjct: 311 LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370
Query: 6901 KLHQLQMD-----------KLPSRHAISEVMSWISLMENVIQ-KDEDNIKNSIGYKAIHE 6948
KL +L + +L A+S++ ++++ + N+ S+ E
Sbjct: 371 KLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 430
Query: 6949 YLQKYKGFKIDI------NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKS 7002
+ +D + L+ D + + S+D E + D DF + GA+ S
Sbjct: 431 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ--DDKDFYLR-GAVGLS 487
Query: 7003 WQILQGLVTEKIQLLEGLLES----WSEYENNVQCLKTWFETQEKRLKQQHRI------- 7051
++ ++L E +++ S E+ ++ L + +++Q I
Sbjct: 488 DVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPT 547
Query: 7052 -----GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--GLALIQNKKEDVSSIVMSTL 7104
L +C D +K E ++++ E++ G + + + + ++
Sbjct: 548 GPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI---- 603
Query: 7105 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL--LTGS 7162
W L ++ +K L +W + I ++L + L + + L+
Sbjct: 604 ----DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD 659
Query: 7163 LEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWN- 7221
++ +++Q+ L+ LQ ++ ++ + ++ + + + L + L ++N RW+
Sbjct: 660 IQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGRWDR 718
Query: 7222 --NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD--IADD 7277
+LLEE LQ AL+Q Q + + S ++ + R NE++ +N D I D
Sbjct: 719 VCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775
Query: 7278 EVATWIQDCNDLLK 7291
+Q ++LL+
Sbjct: 776 HHKQLMQIKHELLE 789
Score = 57.4 bits (137), Expect = 6e-07
Identities = 171/974 (17%), Positives = 361/974 (37%), Gaps = 120/974 (12%)
Query: 3128 GELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQD 3187
GE L+ + KA I+ K+ + W++ + + L+ + ++ + + ++
Sbjct: 2 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 3188 WLSKTEK-----MVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE 3242
WL+ E +V++S N ++ K EQQ+LQ +E+ + L E +
Sbjct: 62 WLAHIESELAKPIVYDSCNS-EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 3243 G---QAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDA 3299
A S + L ++ + ++ E+ +++ +F +DW+ +
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
Query: 3300 IHMLDSYCHPTSD---KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3356
+ P+S +V K EA E Q+++I + + + +
Sbjct: 181 ER---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 237
Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
+++Q + W +L +L+ + + ++ W+ M+ L E
Sbjct: 238 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297
Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGM---TEHYVTQLELQDLQERY 3473
H D + + K +E+ + +E I +G + +E + ++L E
Sbjct: 298 --HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
Query: 3474 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3533
R QE +KL+RL L E L + +L+ + L D H H+ +
Sbjct: 356 RYCQEVFGRVERYHKKLIRL------PLPDDEHDLSDRELELEDSAAL-SDLHWHDRSAD 408
Query: 3534 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3593
L Q +L + R + +++S+ +W H +R
Sbjct: 409 SLLSPQPSSNLSLSLAQPLRSERSG-------RDTPASVDSIPLEW---DHDYDLSRDLE 458
Query: 3594 NNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
+ + L +++ Q ++ +S +S A ++ + +K + +A
Sbjct: 459 SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
Query: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
++ ++G + LD+S Q+ + + + + E ++S
Sbjct: 519 QIRQLG----KALDDSR--------------------FQIQQTENIIRSKTPTGPELDTS 554
Query: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEK---GHSLLKSAREK 3770
Y G ++ ID V K LE LK+ E+ G L S +
Sbjct: 555 YKGYMKLLG-------ECSSSIDSV---------KRLEHKLKEEEESLPGFVNLHSTETQ 598
Query: 3771 GERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQ 3830
+ E +A+ L KE+ +++ L ++F+ ++
Sbjct: 599 TAGVIDRWELLQAQALSKELR-------------------MKQNLQKWQQFNSDLNSIWA 639
Query: 3831 WIAEYQEILHVPE--EPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-- 3886
W+ + +E L + E ++ + Q+ K K LQ+ V + + S+ +
Sbjct: 640 WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS 699
Query: 3887 VQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLV 3946
+ L+D++ Q+ + +CS+ +E L+ + + ++ E+ +L+ R
Sbjct: 700 KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-EMSHGLLLMLENIDRRK 758
Query: 3947 APDLLETSSLETITQQLAHHKAMME---EIAGFEDRLNNLQMKGDTLI--GQCADHLQAK 4001
+ S+L+ Q HHK +M+ E+ + R+ +LQ L+ + D L+AK
Sbjct: 759 NEIVPIDSNLDAEILQ-DHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAK 817
Query: 4002 LKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEP 4061
K H+ G + + R + LE L S+QD +W SA + D
Sbjct: 818 EK----VHVIGNR--LKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELDTSG 867
Query: 4062 SPQPPLSRAEAIKQ 4075
S P R+ +Q
Sbjct: 868 SVSPTSGRSTPNRQ 881
Score = 52.4 bits (124), Expect = 2e-05
Identities = 53/268 (19%), Positives = 111/268 (41%), Gaps = 26/268 (9%)
Query: 6984 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 7043
S S ++ +LG +N WQ L L+ +++ L+ L + + + N+ L+TW E
Sbjct: 9 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 68
Query: 7044 RLKQQ--HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKE------- 7094
L + + + +Q L + Q+L ++++EK G+A + N E
Sbjct: 69 ELAKPIVYDSCNSEEIQRKLNEQQEL-------QRDIEK-HSTGVASVLNLCEVLLHDCD 120
Query: 7095 ------DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7148
+ SI +T R L + W N+ M + ++ ++ W + + +L
Sbjct: 121 ACATDAECDSIQQAT-RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
Query: 7149 ARYSLSRFRLLTGSLEAV-QVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 7207
+ + + F +G + V + ++ + Q + + L+ +L +E
Sbjct: 180 SERT-AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
Query: 7208 TLTNTLKEVNMRWNNLLEEIAEQLQSSK 7235
+L + E N RW+NL + + L+ K
Sbjct: 239 SLKQMVHEGNQRWDNLQKRVTSILRRLK 266
Score = 52.4 bits (124), Expect = 2e-05
Identities = 148/822 (18%), Positives = 313/822 (38%), Gaps = 82/822 (9%)
Query: 4314 VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK- 4372
++ + + RW L DLI +++ L + + L W + +A+ +
Sbjct: 17 IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76
Query: 4373 QSPPPDMAQNLLMDHLAICSELEAKQM-------LLKSLIKDADRVMADLGLNERQVIQK 4425
S + Q L + + ++E L + L+ D D D E IQ+
Sbjct: 77 DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA---ECDSIQQ 133
Query: 4426 ALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4485
A + + + +RR + + +FL + ++ ER F ++
Sbjct: 134 ATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVI 193
Query: 4486 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4545
+++K ++ Q + ++ + Q R L +E + + E +D+
Sbjct: 194 YTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDN 253
Query: 4546 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKY 4605
+ ++ + L+ L+ + R+ F+ D WL + D+ ++ + SE Q AK
Sbjct: 254 LQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL----QLTNIEHFSECDVQ-AKI 308
Query: 4606 QNILEQSPEY---ENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK-- 4660
+ + E N + + G+ ++ +D + + E+L+ L R + +
Sbjct: 309 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERY 368
Query: 4661 ----------DKFYKVQEAILARKEYASLIEL--------------TTQSLSELEAQFLR 4696
D + + + L ++ A+L +L + +LS AQ LR
Sbjct: 369 HKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLR 428
Query: 4697 MSKVPTDL-AVEEALSLQ-----DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPD 4750
+ D A +++ L+ D R + ++ + DE Q + F G D
Sbjct: 429 SERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSD 488
Query: 4751 KML-HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLK----SVKEEQSKVN 4805
M+ Y +L + +++T+ + E +QL + L +++ ++ +
Sbjct: 489 VMIPESPEAYVKLTE------NAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 542
Query: 4806 EETLPAEE---KLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQ 4862
+T E K Y L G S +KR+ L++ L H ++
Sbjct: 543 SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV---NLHSTETQT 599
Query: 4863 GELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDL--N 4916
+ + E RM Q++ F ++++ WL + EL L+L +
Sbjct: 600 AGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD 659
Query: 4917 LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGD 4976
+Q I+ +I+K++ Q+ V I+ +++ E FT+A S DL+ L++++
Sbjct: 660 IQTIELQIKKLKELQKAVDHRKAIILSINLCSPE-FTQADSKESRDLQDRLSQMNGRWDR 718
Query: 4977 IQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED----AQELLQLAGNGLDVESAEENL 5032
+ L + L + QCQ ++++ LE+ E++ + N LD E +++
Sbjct: 719 VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSN-LDAEILQDHH 777
Query: 5033 KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQK 5074
K M+ + + L + L L+ G + LE K
Sbjct: 778 KQLMQIKHELLESQLRVASLQDMSCQL--LVNAEGTDCLEAK 817
Score = 52.4 bits (124), Expect = 2e-05
Identities = 64/353 (18%), Positives = 156/353 (44%), Gaps = 21/353 (5%)
Query: 6694 LDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 6753
LD+ + ++ + ++ S P+ E + + L SS++ + +++ ++
Sbjct: 527 LDDSRFQIQQTENIIRSKTPTG---PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
Query: 6754 KRLLISISCSDLESQLNQLGECW-LSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 6812
+ L ++ E+Q + + W L +SKEL R++ L+ W ++ S+ + WL
Sbjct: 584 ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL-RMKQNLQKWQQFNSDLNSIWAWLG 642
Query: 6813 SAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 6872
++ LE Q + + +++ + + E K VD + ++ S+ + +
Sbjct: 643 DTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
Query: 6873 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM-ENVIQ 6931
++ L+ LS+++ +W + ++ E+ L D L E+ + LM EN+ +
Sbjct: 701 ESRDLQDRLSQMNGRW----DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
Query: 6932 KDED--NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6989
+ + I +++ + + ++ ++ K ++ QL V + Q+ V ++ +D
Sbjct: 757 RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL---VNAEGTDC 813
Query: 6990 TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 7042
+ E++ + ++L V+ I+ LE LL + ++ Q L +W E
Sbjct: 814 LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE 862
Score = 52.0 bits (123), Expect = 3e-05
Identities = 177/930 (19%), Positives = 351/930 (37%), Gaps = 131/930 (14%)
Query: 5936 KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRS 5995
KLG + W+ L ++I+ + + L E L Q+ ++ S+ T + IE SE +P
Sbjct: 20 KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE---SELAKPIVY 76
Query: 5996 PESQMAEHQALMDEILMLQDEINELQSSLAE-----ELVSESCE--ADPAEQLALQSTLT 6048
E Q ++E LQ +I + + +A E++ C+ A AE ++Q
Sbjct: 77 DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
Query: 6049 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDT 6108
L R I + +R +EE + Q++ + + WL S++ T
Sbjct: 137 NLDRRWRNICAMSMERRLKIEETW----------RLWQKFLDDYSRFEDWLKSSER---T 183
Query: 6109 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 6168
A P + + + Q L++L + N+ + + D A L
Sbjct: 184 AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243
Query: 6169 LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ--- 6225
+ LQ+ + ++ ++EE + T + WL + T
Sbjct: 244 VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE-----TARDSILVWLTEMDLQLTNIEH 298
Query: 6226 ----QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE 6281
Q+ ++Q K +QE++ + + + ++GE+++ + + + ++ +E
Sbjct: 299 FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--------IIEEE 350
Query: 6282 LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKG 6341
L D++R + + K L + + E L R L L
Sbjct: 351 L----------DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL--S 398
Query: 6342 DVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATST----WLDDV 6397
D+ D+SA SLL + SS + Q + E+ D ++ + W D
Sbjct: 399 DLHWHDRSA-DSLLS------PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 451
Query: 6398 EERLFVATAL---LPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR-DV 6453
+ + +A+ LP E E +++ + +S+ M PE+ + +
Sbjct: 452 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM----------IPESPEAYVKL 501
Query: 6454 IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDL--KVLFTSLADNKYIILQKL 6511
E+ + G S L+S + Q + + QI +N + K D Y KL
Sbjct: 502 TENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 561
Query: 6512 ANVFEQPVAEQIEAIQQAEDGLKEFD---AGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6568
+ I+++++ E LKE + G + L + + + + D ++
Sbjct: 562 LG----ECSSSIDSVKRLEHKLKEEEESLPGFVNL----------HSTETQTAGVIDRWE 607
Query: 6569 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 6628
L S+ + QNL Q+ L + L +E++ Q++ +S+ + +L
Sbjct: 608 LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667
Query: 6629 KHKEYFQGLESH---MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE 6685
K + Q H +IL+ L + A KE++ + ++Q + R
Sbjct: 668 KKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS------ 721
Query: 6686 YILETWSHLDEDQ-------QELSR----QLEVVESSIPSVGLVEENEDR--LIDRITLY 6732
+LE W L +D E+S LE ++ + ++ N D L D
Sbjct: 722 -LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
Query: 6733 QHLKSSLNEYQPKLYQVLDDGKRLLIS---ISCSDLESQLNQLGECWLSNTNKMSKELHR 6789
+K L E Q ++ + D +LL++ C + + +++ +G ++S+ +
Sbjct: 781 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
Query: 6790 LETILKHWTRYQSESADLIHWLQSAKDRLE 6819
LE +L S DL W S+ D L+
Sbjct: 841 LEKLLD----VSSSQQDLSSW--SSADELD 864
Score = 50.4 bits (119), Expect = 8e-05
Identities = 141/728 (19%), Positives = 273/728 (37%), Gaps = 177/728 (24%)
Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQ 4918
Q W K +TS + + + Q +F+T L WL + +L+ + +
Sbjct: 249 QRWDNLQKRVTSIL----RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SEC 302
Query: 4919 DIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQ 4978
D+Q +I++++ Q+E+ + + + + ++ K++ L +A +E L EL
Sbjct: 303 DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY----- 357
Query: 4979 EALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEF 5038
E++ + +RY++ L L + D+ E L+
Sbjct: 358 ---------CQEVFGRVERYHKKLIR-----------LPLPDDEHDLSDRELELEDS--- 394
Query: 5039 FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQR 5098
+ L +LH + D L+ P +L +A LRS+R RD+ A VD +
Sbjct: 395 --------AALSDLHWHDRSADSLLSPQPSSNLSLSLAQ-PLRSERSGRDTPASVDSI-- 443
Query: 5099 CTAQW-HDYQKARE-----------EVIELMNDTEKKLS---EFSLLKTSSSHEAEEKLS 5143
+W HDY +R+ E E +D + L S + S EA KL+
Sbjct: 444 -PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 502
Query: 5144 E---------HKALVSVVNSFHEKIVALEEKASQLEKTGN-DASKATLSRSMTTVWQRWT 5193
E H AL S + + AL++ Q+++T N SK + T ++ +
Sbjct: 503 ENAIKNTSGDHSALESQIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYM 559
Query: 5194 RLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEY 5253
+L + E + + VK+ + + ++ LPG +
Sbjct: 560 KL--------------LGECSSSIDSVKRLEHKLKEEEESLPG-------------FVNL 592
Query: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT 5313
H T QT ++ DR +Q + +
Sbjct: 593 HST---------------ETQTAGVI----------------------DRWELLQAQALS 615
Query: 5314 NGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQN 5373
+KQ L+ + + +NS+ W+ +T+E +LE+LQ L E + Q
Sbjct: 616 KELRMKQNLQKWQQFNSDLNSIWAWLGDTEE-----------ELEQLQRL--ELSTDIQT 662
Query: 5374 IEKMAEEQKEKYLGLYTILPSELSLQLAE---VALDLKIRDQIQDKIKE----------- 5419
IE ++ KE + LS+ L D K +QD++ +
Sbjct: 663 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSL 722
Query: 5420 VEQSKATSQELSRQIQ---KLAKDLTTILTKLKAKTDNVV--QAKTDQKVLGE---ELDG 5471
+E+ + Q+ Q Q +++ L +L + + + +V + D ++L + +L
Sbjct: 723 LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 782
Query: 5472 CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS-KLNQAASHLE 5530
+L+E V + + QL L G ++ + NRL L + + H++
Sbjct: 783 IKHELLESQLRVASLQDMSCQL---LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839
Query: 5531 EYNEMLEL 5538
E ++L++
Sbjct: 840 ELEKLLDV 847
Score = 47.8 bits (112), Expect = 5e-04
Identities = 152/743 (20%), Positives = 287/743 (38%), Gaps = 100/743 (13%)
Query: 1721 ESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1780
E L + + ++ L ++++RW+ L +I R+ L+ + QQ D+ + S W
Sbjct: 3 ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
Query: 1781 IKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLH 1840
+ SEL + ++ E++ K E Q LQ + K S G A L+
Sbjct: 63 LAHIESELAK-----------PIVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGVASVLN 110
Query: 1841 LLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKN 1900
L + DC +A + Q A +L ++ ++S + R +E T + +
Sbjct: 111 LCEVLLHDCDACATDAE--CDSIQQATRNLDRRWRNICAMS---MERRLKIEETWRLWQK 165
Query: 1901 ESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT--SCRATADQLCGE 1958
D + D L++++ + S I + A+ LK + QR C + + +
Sbjct: 166 FLDDYSR-FEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 224
Query: 1959 VERIQNLLGTKQSEADALAVLKKAFQD---QKEELLKSIEDIEERTDK-ERLKEPTRQAL 2014
R+ +++ D+ LK+ + + + L K + I R +E A
Sbjct: 225 YRRL-----ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 279
Query: 2015 QQRLRVFNQLEDELNSHEH-ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRL 2073
L +++ +L + EH C ++ K KQ+ AF E+ N++E ++L
Sbjct: 280 DSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK----AFQQEISLNHNKIEQIIAQGEQL 335
Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSKV---LENASSVIVTRTTIKDQEDL--KWAFSKH 2128
I +++ +I+ E L+ +V +E ++ D+ DL + +
Sbjct: 336 IEKSEPLDAAIIE--EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELED 393
Query: 2129 ETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVD----KW---LDV 2181
A + +++ + D+ S L D ++VD +W D+
Sbjct: 394 SAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 453
Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFE 2241
S LE M R L + DE + + A +S++ E +K E
Sbjct: 454 SRDLESAMSR----------ALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
Query: 2242 SEVKNKALRLEELHSKVNDLKELTKNLETPP-DLQFIEADLMQKLEHAKEITEVAKGTLK 2300
+ +KN + L S++ ++L K L+ +Q E + K E+ KG +K
Sbjct: 504 NAIKNTSGDHSALESQI---RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMK 560
Query: 2301 DFTAQSTQVEKFINDITTWFTKVEESL---MNCAQNET-------------CEALKKVKD 2344
S+ ++ + + + EESL +N ET +AL K
Sbjct: 561 LLGECSSSIDS-VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619
Query: 2345 IQKELQS-QQSN---------ISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS- 2393
+++ LQ QQ N + T+E L L R S +++++ + L + +AV
Sbjct: 620 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDH 679
Query: 2394 --------QLCSK--TQASLQES 2406
LCS TQA +ES
Sbjct: 680 RKAIILSINLCSPEFTQADSKES 702
Score = 46.6 bits (109), Expect = 0.001
Identities = 157/826 (19%), Positives = 311/826 (37%), Gaps = 150/826 (18%)
Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
M ++A H+ A+E+E K G++ HL L L+ + + +E
Sbjct: 1 MGERLAKASHESKASEIEYKLGKVNDRWQHL-----------LDLIAARVKK----LKET 45
Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
V++ +S L + L+ I +L + + +S N E I++ LN+ +
Sbjct: 46 LVAVQQLDKNMSSLRTW------LAHIESELAKPI-VYDSCNSEE---IQRKLNEQQELQ 95
Query: 1917 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATA-DQLCGEVERIQNLLGTKQSEADA 1975
+ +E + + +L+ + L C A A D C +++ L + A
Sbjct: 96 RDIEKHSTGVASVLNLCEVLLH--------DCDACATDAECDSIQQATRNLDRRWRNICA 147
Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLK-EPTRQALQQRLRVFNQLEDELNSHEHE 2034
+++ + RLK E T + Q+ L +++ ED L S E
Sbjct: 148 MSM------------------------ERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT 183
Query: 2035 LCW------LKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ-GQCCGLIDL 2087
+ + AK+ +K AF +V + +LE+ +RL EN+ C L +
Sbjct: 184 AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243
Query: 2088 MRE----YQNLKSAVSKVLENASSVIVTRTTIKDQED--LKWAFSKHETAKNKMNYKQKD 2141
+ E + NL+ V+ +L I R + D L W +M+ + +
Sbjct: 244 VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWL--------TEMDLQLTN 295
Query: 2142 LDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK--------LEENMDRLR 2193
+++F+ + K + SL +E + + + EK +EE +D LR
Sbjct: 296 IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
Query: 2194 -----------------VSLSIWDDV--LSTRD-EIEG--------WSNNCV-----PQM 2220
+ L + DD LS R+ E+E W + PQ
Sbjct: 356 RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 415
Query: 2221 AENIS-NLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKEL------TKNLETPPD 2273
+ N+S +L LR+E ++ + V + L + + DL+ +++ E D
Sbjct: 416 SSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD 475
Query: 2274 LQFI--------EADLMQKLEHAKEITEVA-KGTLKDFTAQSTQVEKF--INDITTWFTK 2322
F + + + E ++TE A K T D +A +Q+ + D + + +
Sbjct: 476 KDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ 535
Query: 2323 VEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS----AELESL 2378
E+++ E K K L S+I S + + L + S L S
Sbjct: 536 QTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST 595
Query: 2379 GRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAKAAAKESSDR- 2435
G+I + E + + ++++L+K F+ + W LG E R
Sbjct: 596 ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW-LGDTEEELEQLQRL 654
Query: 2436 --TGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKAN 2493
+ D + +E ++ L+ + +V ++ + ++ SK+ +Q+++++ N
Sbjct: 655 ELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE-SRDLQDRLSQMN 713
Query: 2494 EEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFN 2539
+ + + LQD + F + L L + ++ R N
Sbjct: 714 GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
Score = 45.1 bits (105), Expect = 0.003
Identities = 81/372 (21%), Positives = 159/372 (42%), Gaps = 52/372 (13%)
Query: 1344 RFETNK-ETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE 1402
RF+ + E ++R TG E S+ L E + + KR E + +KE
Sbjct: 531 RFQIQQTENIIRSKTPTGP--ELDTSYKGYMKLLGECSSSIDSVKRLE-------HKLKE 581
Query: 1403 ASEIPLGPQNKQLLQQQAKSIKEQVKKLE-DTLEEDIKTMEMVKTKWDHFGSNFETLSVW 1461
E G N + Q + ++ + L+ L ++++ + ++ KW F S+ ++ W
Sbjct: 582 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ-KWQQFNSDLNSIWAW 640
Query: 1462 ITEKEKELNALE-----TSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTT 1516
+ + E+EL L+ T +++QI ++K + ++ + + I+ + + F Q +
Sbjct: 641 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQ-ADS 699
Query: 1517 GESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEE---NLRKIQQSVSEFED 1573
ES ++ +L+Q+ + + + G + L Q Q F E L + +++ ++
Sbjct: 700 KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
Query: 1574 KLAVPIKICSSATETYKVLQEHMDLC-----QALESLSSAITAFSASARKVVNRDSCVQE 1628
++ VPI A ++LQ+H + LES + S + +VN +
Sbjct: 760 EI-VPIDSNLDA----EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEG---- 810
Query: 1629 AAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDI--- 1685
D L AKE+ + N L + L KE+S + LE+ SS + D+
Sbjct: 811 --------TDCL-EAKEKVHVIGNRL---KLLLKEVSRHIKELEK-LLDVSSSQQDLSSW 857
Query: 1686 -SADRVKVEGEL 1696
SAD + G +
Sbjct: 858 SSADELDTSGSV 869
Score = 41.6 bits (96), Expect = 0.035
Identities = 46/220 (20%), Positives = 81/220 (36%), Gaps = 45/220 (20%)
Query: 578 EEAENVMKFMN----ETTA-----QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAW 628
EE E++ F+N ET +W L + S +++ + W ++ + + S+ AW
Sbjct: 581 EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 640
Query: 629 LEDAEKMLNQSENAKKDF-----------FRNLPHWIQQHTAMNDAGNFL---IETCDEM 674
L D E+ L Q + + + L + A+ + N D
Sbjct: 641 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
Query: 675 VSRDLKQQLLLLNGR----------WRELFMEVKQYAQA------------DEMDRMKKE 712
SRDL+ +L +NGR WR L + Q + +DR K E
Sbjct: 701 ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNE 760
Query: 713 YTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDI 752
L A + H K ++ + +L + L+D+
Sbjct: 761 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 800
Score = 40.0 bits (92), Expect = 0.10
Identities = 50/269 (18%), Positives = 111/269 (41%), Gaps = 33/269 (12%)
Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMS-GLGSV 7593
++W+ + +A + + +++WQ++ + WL ++ L +S + ++
Sbjct: 604 DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
Query: 7594 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 7653
+ +++ + L V ++ + IL++ ADS LQ L+++ +
Sbjct: 664 ELQIKKLKELQKAVDHRKAI--------ILSINLCSPEFTQADSKESRDLQDRLSQMNGR 715
Query: 7654 WKSASMRLEEQKKKLAFLL---KDWEKCEKGIADSLEKLRTFKKKL--------SQSLPD 7702
W LEE + L L + + + G+ LE + K ++ ++ L D
Sbjct: 716 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775
Query: 7703 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELL----Q 7758
HH++L + E + V S D QL + + + + + ++ R++LL
Sbjct: 776 HHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVS 835
Query: 7759 RQWEELCHQLSLRRQQIGERLNEWAVFSE 7787
R +EL L + Q + L+ W+ E
Sbjct: 836 RHIKELEKLLDVSSSQ--QDLSSWSSADE 862
Score = 39.3 bits (90), Expect = 0.17
Identities = 45/254 (17%), Positives = 104/254 (40%), Gaps = 12/254 (4%)
Query: 7003 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALK 7062
W++LQ K ++ L+ W ++ +++ + W E+ L+Q R+ +Q
Sbjct: 606 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665
Query: 7063 DCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTLRELGQTWANLDHMVGQ 7120
+ L++L KA + I L + + D S + L ++ W + ++ +
Sbjct: 666 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 725
Query: 7121 LKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR----LLTGSLEA--VQVQVDNLQ 7174
+ LL+ L Q F +++ L+ ++ R + + +L+A +Q L
Sbjct: 726 WRGLLQDALMQCQ----GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
Query: 7175 NLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSS 7234
++ +L + + + ++ QLL + + R LL+E++ ++
Sbjct: 782 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 841
Query: 7235 KALLQLWQRYKDYS 7248
+ LL + +D S
Sbjct: 842 EKLLDVSSSQQDLS 855
Score = 38.9 bits (89), Expect = 0.23
Identities = 53/276 (19%), Positives = 120/276 (43%), Gaps = 25/276 (9%)
Query: 1108 LRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDT---ANHGEVK 1164
L+A S ++ ++ KW+ + S + +W+ E +L+ ++ + T ++K
Sbjct: 609 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 668
Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
+ ++E++ V R + + T+ S+ E++ D L++++ + + +LL E
Sbjct: 669 K-LKELQKAVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEW 726
Query: 1225 EKMLSN-FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTK 1283
+L + C + E+ L L + + + +I+ ++ +A+ L HH+Q +
Sbjct: 727 RGLLQDALMQCQGFHEMSHGLLLML----ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 782
Query: 1284 RISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ--ERRIQVTLRK 1341
++ ++ ++Q L D + L E T D LE + R+++ L++
Sbjct: 783 --------IKHELLESQLRVASLQDMSCQLLVNAEGT-DCLEAKEKVHVIGNRLKLLLKE 833
Query: 1342 WERFETNKETVVRYLFQTGSSHERFLSFSSLESLSS 1377
R E L SS + S+SS + L +
Sbjct: 834 VSRHIKELEK----LLDVSSSQQDLSSWSSADELDT 865
Score = 37.0 bits (84), Expect = 0.87
Identities = 62/365 (16%), Positives = 136/365 (37%), Gaps = 17/365 (4%)
Query: 7411 DRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWME 7470
+RL + + ++ E K + +N W + R KL+ L+ Q + +
Sbjct: 3 ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 7471 FLVQTEQKLAVEI---SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV 7527
+L E +LA I S N + + + + Q ++ + S++ + LL
Sbjct: 62 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 7528 ----DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS 7583
+ D L +W+ + + +RR I+ R WQ++ + + WL
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-- 179
Query: 7584 YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE----AGKQLLLSADSGA 7639
+ P T+ E K + F RQ + +E ++L + +
Sbjct: 180 ---SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
Query: 7640 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7699
+L+ + E ++W + R+ ++L + E+ E L L +L+
Sbjct: 237 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296
Query: 7700 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
++ A+ + K + + + + Q+ + L D +I+ E ++ L+R
Sbjct: 297 EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
Query: 7760 QWEEL 7764
+E+
Sbjct: 357 YCQEV 361
Score = 37.0 bits (84), Expect = 0.87
Identities = 59/369 (15%), Positives = 151/369 (40%), Gaps = 43/369 (11%)
Query: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWL--------- 629
+A + + + +W++L + + L+E + + ++SL+ WL
Sbjct: 13 KASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK 72
Query: 630 ---------EDAEKMLNQSENAKKDFFRNLPHWIQQHT----AMNDAGNFLIETCDEMVS 676
E+ ++ LN+ + ++D I++H+ ++ + L+ CD +
Sbjct: 73 PIVYDSCNSEEIQRKLNEQQELQRD--------IEKHSTGVASVLNLCEVLLHDCDACAT 124
Query: 677 ----RDLKQQLLLLNGRWREL-FMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKL 731
++Q L+ RWR + M +++ + +E R+ +++ D + + +
Sbjct: 125 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
Query: 732 SEPLE--VSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
+ P V + K ++ E +++V Q ++I K + +E+ + + +
Sbjct: 185 AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMV 244
Query: 790 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
+ ++ +++ + +L + + EE E S L +++ +T +E ++
Sbjct: 245 HEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDV 304
Query: 850 LFKQKHQELLACQE----NCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIH 905
+ K ++L A Q+ N K +I +G Q ++K L + + L+R ++
Sbjct: 305 --QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVF 362
Query: 906 VAFQSMVKK 914
+ KK
Sbjct: 363 GRVERYHKK 371
Score = 36.2 bits (82), Expect = 1.5
Identities = 139/775 (17%), Positives = 298/775 (38%), Gaps = 106/775 (13%)
Query: 1402 EASEIP--LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLS 1459
+ASEI LG N + Q I +VKKL++TL + ++ K N +L
Sbjct: 13 KASEIEYKLGKVNDRW-QHLLDLIAARVKKLKETL---VAVQQLDK--------NMSSLR 60
Query: 1460 VWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSS-IVGLEEEAQSFAQFVTTGE 1518
W+ E EL S +I + QE++ + G+ + +
Sbjct: 61 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 1519 SARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLR---KIQQSVSEFEDKL 1575
+ A+ I++ L + + + ++ K EE R K S FED L
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAM---SMERRLKIEETWRLWQKFLDDYSRFEDWL 177
Query: 1576 AVPIKIC---SSATETYKVLQEHMDLCQALE-SLSSAITAFSASARKV--VNRDSCVQEA 1629
+ SS+ Y V +E + +A + + +T ++ + R++ A
Sbjct: 178 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 237
Query: 1630 AALQQ-------QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPE 1682
+L+Q +++++ +R L++ + + E S L WL + + ++ E
Sbjct: 238 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297
Query: 1683 MDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQL 1742
D V+ +++ ++A Q E+ + +++ E L + D +++ E+L
Sbjct: 298 HFSECD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE---EEL 351
Query: 1743 DERWRDLPQIINKRINFLQSVVA------EHQQFDELL-------LSFSVWIKLFLSEL- 1788
DE R ++ + + + ++ EH D L LS W L
Sbjct: 352 DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLL 411
Query: 1789 --QTTSEISIMDHQVALTRH--KDHAAEVES----------KKGELQSLQGH-LAKLGSL 1833
Q +S +S+ Q + +D A V+S +L+S L
Sbjct: 412 SPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471
Query: 1834 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEA 1893
G+ + L+G + E+ + + L + + H++L +RQL + ++
Sbjct: 472 GQDDKDFYLRGAVGLSDVMIPESPEAYVK--LTENAIKNTSGDHSALESQIRQLGKALDD 529
Query: 1894 TNSMNKNESDLIEK------DLNDALQN-AKALESAAVSLDGILSKAQYHLK-------- 1938
+ + ++I +L+ + + K L + S+D + + ++ LK
Sbjct: 530 SRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV-KRLEHKLKEEEESLPG 588
Query: 1939 ---IGSSEQRTSC------RATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEE 1989
+ S+E +T+ A L E+ QNL +Q +D ++ A+ EE
Sbjct: 589 FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW--AWLGDTEE 646
Query: 1990 LLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKD 2049
L+ ++ +E TD Q ++ +++ +L+ ++ + + + + + Q D
Sbjct: 647 ELEQLQRLELSTDI--------QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 698
Query: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLEN 2104
+ ++ ++++ WD L+ E +G + + + + + +LEN
Sbjct: 699 SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 753
Score = 35.4 bits (80), Expect = 2.5
Identities = 53/282 (18%), Positives = 123/282 (43%), Gaps = 29/282 (10%)
Query: 2704 QTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQ 2761
+TQ + + W + + ++ + ++ + +W + N + W+ ++++E L+
Sbjct: 596 ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE 655
Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQF 2821
++ + + L+ L +A DH +A+ +++ + E T+ +S + ++ +Q
Sbjct: 656 LSTDIQTIELQIKKLKE-LQKAVDHRKAI--ILSINLCSPEFTQADSKESRDLQDRLSQM 712
Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWS------DMSGDSSA 2875
N + + +++D LM HE + L E + R D + D+
Sbjct: 713 NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
Query: 2876 TQ---KKLSKIK-ELIDSREIGASRLSRVESLAPEVKQNTTASGC----ELMHTEMQALR 2927
Q K+L +IK EL++S+ R++ ++ ++ ++ N + C E +H L+
Sbjct: 773 LQDHHKQLMQIKHELLESQ----LRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 828
Query: 2928 ADWKQWEDSVFQTQSCLENLVSQMALS------EQEFSGQVA 2963
K+ + + + L+ SQ LS E + SG V+
Sbjct: 829 LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVS 870
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 372 bits (955), Expect = e-102
Identities = 717/4026 (17%), Positives = 1587/4026 (39%), Gaps = 438/4026 (10%)
Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 1314 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1370
Query: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1371 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1429
Query: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
T +V +Y+ G S +R +SL E ++ E +K +
Sbjct: 1430 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1487
Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1453
+K+A + P +KQ K E++ ++ L E ++T+++ K D +
Sbjct: 1488 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1541
Query: 1454 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1506
E + E + L L+ S ++ D+++ + + QE + KL I L +
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601
Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1566
++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1602 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1658
Query: 1567 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1626
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1659 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1700
Query: 1627 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1673
A++++ E + +++ +E +T +ENLL ++K+ + T +
Sbjct: 1701 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1756
Query: 1674 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1713
G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1757 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1816
Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1817 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1874
Query: 1774 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1828
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 1875 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1934
Query: 1829 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
K+ + ++ A D F+ V+ L L + Q
Sbjct: 1935 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 1991
Query: 1877 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1930
+ S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++ +
Sbjct: 1992 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2050
Query: 1931 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1988
A+ L S + + T D + G E + + + + + QD +
Sbjct: 2051 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2110
Query: 1989 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
E+L + ++E ++ ALQ + LE ++ + + + +K K+ +
Sbjct: 2111 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2170
Query: 2049 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
D + A + ++ L + + E + L + ++NL + LE +
Sbjct: 2171 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2230
Query: 2108 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2162
+ T + KD +L Y Q+ F KHL S LK+I S
Sbjct: 2231 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2276
Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2216
+ +D ++K ++S+K +E D ++ + V S +++++ + +
Sbjct: 2277 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2330
Query: 2217 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2269
+ + + + + AE+L K E K + +L+ E+ KVN+ L L +
Sbjct: 2331 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2389
Query: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2328
TP AK I V G + + +T E+F + T +++ +
Sbjct: 2390 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2431
Query: 2329 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
+ + L +KD EL ++ S + QE +++ + + T
Sbjct: 2432 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2490
Query: 2389 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2448
EAV KTQ +S E +++ + QE L+ KL +
Sbjct: 2491 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2524
Query: 2449 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
L + + T A KQ+ +T+ + ++Q + + +Q
Sbjct: 2525 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2561
Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2562 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2619
Query: 2569 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2624
+ ++L+ GQ +LS G G + QL Q +T + C A+
Sbjct: 2620 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2679
Query: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2682
+ + L+S+ + + ++L+ + + D + ++L Q + + + + ++K+
Sbjct: 2680 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2739
Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2740 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2798
Query: 2743 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2793
+ W+++ +Q HP+ + LD L+S++ + +D ++ L +
Sbjct: 2799 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2849
Query: 2794 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y + V
Sbjct: 2850 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2908
Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
W+ Q L +IK +D E G + +++++SL E+ Q+
Sbjct: 2909 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2950
Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
EL++ +L + + ++ V L V + + + Q +
Sbjct: 2951 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3008
Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
+F + K +QL + + + + + L LQ + + LK Q++ R +
Sbjct: 3009 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3068
Query: 3031 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3071
+DL + G + +E++ L Q + C E LQ +
Sbjct: 3069 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3128
Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3131
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 3129 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3188
Query: 3132 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3191
L+ GI+ + A + +E +E ++++F + L K
Sbjct: 3189 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3242
Query: 3192 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3246
E+ HE S + + QQ + + EP L+ K Q + W GQ +A
Sbjct: 3243 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3296
Query: 3247 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 3297 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3356
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
++ + P+++ V+ ++ + + L + +++ +++I GE + P I +
Sbjct: 3357 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3416
Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
QL + W +LL+ QLEG + + + + W+ ++E L E +
Sbjct: 3417 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3476
Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3475
+ + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3477 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3536
Query: 3476 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3532
IQE++ ++ + + + D WL + +KL + SV + ++ L
Sbjct: 3537 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3596
Query: 3533 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
R LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3597 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3654
Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWHEE 3647
+ R + +++ WL E E +S T+ + Q+ ++KK +
Sbjct: 3655 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3714
Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
A D + EV + E++ +R G + + RY+ + + ++++ ++ I
Sbjct: 3715 NKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3771
Query: 3706 SLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
++ + + + W T K + + + D+ + +K T+E+L +
Sbjct: 3772 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKD 3826
Query: 3763 LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3822
++ + G + + E E + ++K++ ++ + + ++ LE+ L +F
Sbjct: 3827 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3886
Query: 3823 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
+ + L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G
Sbjct: 3887 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3946
Query: 3883 LLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
LLEL + ++++K + Y + K+ +L+ + ++ ++ ++ + L +
Sbjct: 3947 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 4006
Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC------ 3994
+ RL P + ++ +E I +Q++ +K + ++ + L+ +G+ +I +
Sbjct: 4007 IVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4065
Query: 3995 --ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
A +Q KL Q N+H ++ + + A++ + H+S T++
Sbjct: 4066 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIK 4118
Query: 4047 QCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLS 4100
Q ++ ++ P ++PS + AE I++ LQE+ ++L L + C +
Sbjct: 4119 DTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPD 4176
Query: 4101 NASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4156
VK + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 4177 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4236
Query: 4157 KRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHL 4214
++LE + + ++K F + +Q + + + L KK EES +H + L
Sbjct: 4237 SPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 4294
Query: 4215 NDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4271
+ W L + N + E L + ++ + +L +
Sbjct: 4295 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 4354
Query: 4272 AVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE 4329
A+ +E K L + + +E + +IE ++ ++ + L QRW +
Sbjct: 4355 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4414
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ +++ Q L + ++L +W + + ++ + P+ A+ L H+
Sbjct: 4415 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4474
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+C+ EAK+ KSL++ +++A + I + +++ + + + +R+ L
Sbjct: 4475 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4534
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4509
+AL+ +F ++ + + Q E+ + L+ D V Q+ K + +++ +
Sbjct: 4535 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4594
Query: 4510 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4569
+ L G L +Q+ + L +QS ++ V+Q+ R + L+ K F E
Sbjct: 4595 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4654
Query: 4570 DFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTI 4629
+ K WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4655 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4714
Query: 4630 LPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L
Sbjct: 4715 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4774
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTG 4744
+E Q V D ++ ++L D +A E+ +V L + EG R
Sbjct: 4775 RVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4832
Query: 4745 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
W +M L T + + + + + LE +E + L L + EQ+
Sbjct: 4833 S-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLR 4889
Query: 4805 NEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4859
LP +E + + L++ L + T + + P + +H I
Sbjct: 4890 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4949
Query: 4860 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4919
+ + + + + S + I Q + L WL+ + L+ D + +
Sbjct: 4950 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEV 5004
Query: 4920 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
I +EI +++ E Q+ + M + +K TK + +AD + + LD
Sbjct: 5005 IPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG 5063
Query: 4980 ALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLA 5019
R ++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 5064 RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFA 5123
Query: 5020 GNGLDV 5025
D+
Sbjct: 5124 NFDFDI 5129
Score = 340 bits (873), Expect = 3e-92
Identities = 720/4013 (17%), Positives = 1591/4013 (39%), Gaps = 492/4013 (12%)
Query: 442 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 1141 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1198
Query: 502 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
K++ + L +L AE+ +K + K E+V + ++N +S + E
Sbjct: 1199 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1255
Query: 551 KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
+ F E ++ ++ K E + D E+A+ +++ +W+N+ V++
Sbjct: 1256 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 1308
Query: 603 SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
+ LE + + Y +T L W++ E NQ EN+K + N +
Sbjct: 1309 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1368
Query: 657 HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
M + + E S +K L +++ + + VK+ D +
Sbjct: 1369 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1425
Query: 710 KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
+E+ D +A T +++ ++ + ++K L ++ + +E+ + K + K
Sbjct: 1426 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1481
Query: 770 AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
I+K + ++ GK F+ E+++ KE S L Q L
Sbjct: 1482 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1541
Query: 819 ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
ELEKQ+ + +S + +E+Q+S K + + + Q+ K+ L
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601
Query: 871 ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
+I G+ ++K+ + L+ D + +A++ ++ +K+ G+
Sbjct: 1602 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1660
Query: 919 -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
K +E +L K E+S+ EL+KV+ A +E E+ ++L T
Sbjct: 1661 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1720
Query: 965 EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
+ + LD +L D+ ++ + +Q +++ H Q D + E +
Sbjct: 1721 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1772
Query: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
LL +D + + + +E + ++ K EKII +H+ V + + L EK+
Sbjct: 1773 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1824
Query: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
Q + EE K ++ +++ L E + T+ L E+ +K+ DYT
Sbjct: 1825 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 1876
Query: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
EF W+ +E +L+ ++ A D ++KR + ++ +G+ S +VL
Sbjct: 1877 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1936
Query: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
S + + + KL + +L S+ + +N D V + +++
Sbjct: 1937 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1996
Query: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
L++G + + A K L +E + + L ++TK + + Q + + ++
Sbjct: 1997 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2055
Query: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
L D L ++ TLD L +S + ++Q+TL + + + ++ +
Sbjct: 2056 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2115
Query: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
+ SS + L+ ++L+ +S + ++ + R SI E VK+ E P
Sbjct: 2116 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 2173
Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
LQ + K + + + +E + ME +KTK + F + E L ++ K + L
Sbjct: 2174 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2233
Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
++ + ++ + E + L + + + A + K +
Sbjct: 2234 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 2293
Query: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
+ +E+ + + + + Q F+ ++ ++ + E
Sbjct: 2294 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 2353
Query: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
ED + K E KV + LC + ++++ A +A S V+N +
Sbjct: 2354 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2413
Query: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
S ++ + YED+ K++ L L+ Q+ ++E S+ + WL+
Sbjct: 2414 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2473
Query: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
+ A+ + D A + +VE L+ V KL +L E
Sbjct: 2474 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2533
Query: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLF 1784
K M L ++D +W++L Q+ R L+ QF + W+ +L
Sbjct: 2534 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2590
Query: 1785 LSELQTTS-----------EISIMDHQVALTRHKDH------AAEVESKKGELQSLQGHL 1827
+S L S ++ I+ + A TR + + S+ GE SL+G +
Sbjct: 2591 VSVLGPLSIDPNMLNTQRQQVQILLQEFA-TRKPQYEQLTAAGQGILSRPGEDPSLRG-I 2648
Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA---------------- 1871
K + L G+ D ++A + Q L L+
Sbjct: 2649 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2708
Query: 1872 --------EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAA 1923
+ L++ + ++Q ++ ++ ++ ++ S L++++ A + ++ LE
Sbjct: 2709 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGIL 2767
Query: 1924 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD-------AL 1976
S + KA+ H+ + S A++ Q Q L TK+ E + L
Sbjct: 2768 KSFKDVEQKAENHV-----QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2822
Query: 1977 AVLKKAFQDQKE--ELLKSIEDIEERTDKE------RLKEPTRQALQQRLRVFNQLEDEL 2028
VL+ +D K+ + L + + E+T E + + + ALQ +L D
Sbjct: 2823 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2882
Query: 2029 N----SHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE---VTWDDTK--------RL 2073
N E++L +KA + ++ P +D+ N LE D + +
Sbjct: 2883 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2942
Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSK-----VLENASSVIVTRTTIKDQ--------ED 2120
+ + Q G+++L+ N +V + V + S+I + +Q E+
Sbjct: 2943 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3002
Query: 2121 LKWAFSKHE----TAKNKMNYKQKDLDNFTSKGKHLLS---------------------E 2155
+ F + + +K ++ ++ LD S G S +
Sbjct: 3003 MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3062
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
L K + D + +D + T D L V E + + L + L T+ + G N
Sbjct: 3063 LAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQN 3121
Query: 2216 CVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2268
+ +M + D+ L R E L++ + +K +LE L + ++ + K +
Sbjct: 3122 TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM 3181
Query: 2269 ----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
ET PDL I+ DL + ++ + A+ A+ QVE I + +++K++
Sbjct: 3182 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTIKRLEEFYSKLK 3234
Query: 2325 E---SLMNCAQNETCEA------------LKKVKDIQKE----LQSQQSNISSTQENLNS 2365
E L ++E + L K QKE LQ +Q +++ + L
Sbjct: 3235 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQ 3294
Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFL 2423
K S + L + + + + +++ ++ A LQE+L F ++++ W +
Sbjct: 3295 SAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3352
Query: 2424 GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2483
+ + + KV++A++ + + + + D +S ++ + +EG+ +
Sbjct: 3353 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3412
Query: 2484 SIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTEN 2542
I +Q++ + ++A L + + L+ + F + LN W+ +E+R N E
Sbjct: 3413 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3472
Query: 2543 LGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
+G + E+ ++++ L + ++ +SL LS R E Q
Sbjct: 3473 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR------EDKDMVQSK 3526
Query: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
SQ+ + + + + Q AL + E + W+ + D+L+
Sbjct: 3527 LDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDY 3584
Query: 2656 SKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLK 2711
S + L K+ S++ +DILL K ++ A+ G + L+ + + +IQ +LE +K
Sbjct: 3585 STEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3640
Query: 2712 EVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI----------EHPLQ 2761
+ DI S TLE + +L W++ V+ ++ E Q
Sbjct: 3641 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3700
Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESFKDTAQEELKTQ 2820
Q KE + +++L + + AL L+ ++RE EK E +
Sbjct: 3701 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED---------NER 3751
Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
+ + +K+ +++ + + A W+ +++L D+ + T +L
Sbjct: 3752 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3811
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
K + EI + ++ + SG ++M + + K+ D V +
Sbjct: 3812 QVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3860
Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD-EEIVECW 2999
+ + S+ L + V Q + E+ L ++ L + E + +
Sbjct: 3861 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3920
Query: 3000 HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY---NCLCLQASK 3056
+ +++ + + + +P + + +L S G+ + ++Y + L Q +
Sbjct: 3921 EEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLYSQIKE 3974
Query: 3057 GCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3116
+ + L + ++ F + + + + + +S ++KI+E +SE++N
Sbjct: 3975 DVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4033
Query: 3117 GQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDWKNFHSNLHQKE 3165
+ + E L ++ + AK +Q K+ W+N H+ + ++E
Sbjct: 4034 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4093
Query: 3166 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHC 3225
+ L ++ + F + + T+ + + + D +++Q+ +++ EEI
Sbjct: 4094 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDG 4153
Query: 3226 YEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3283
+ +L+ + +L G+ + + +L+S + +L+ K+++ +L+ +
Sbjct: 4154 LQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAV 4213
Query: 3284 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
Q+ G++ + DW+ A L S +D + + +L+ S +++I+M+ + +
Sbjct: 4214 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4273
Query: 3344 GESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E +L+ + E T+Q L +K +W SL I + +LEGAL +Q + +
Sbjct: 4274 AELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4333
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYV- 3461
W+ E L+E + + + L K +L +VL++ S +E + G + E
Sbjct: 4334 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4393
Query: 3462 -----TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD 3516
Q +L+ L +R++ + E+ ++ + + +R + + +++ + WL + L
Sbjct: 4394 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4453
Query: 3517 QYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALE 3573
L G T + L E+ + S++ + ++ AE D+ +
Sbjct: 4454 ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN 4513
Query: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
+L++ W++ + +L+E +T+ +N Q WL AE+ ++ +R T
Sbjct: 4514 NLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT 4573
Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLL 3691
Q+ + K + EV ++R+++ E+ + S + + + SR++ ++
Sbjct: 4574 VLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQ 4633
Query: 3692 QVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLK 3748
+++E+ + L++ + ++ + S +W + K+ + +A DK+ T +L
Sbjct: 4634 RLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKT-----QLA 4688
Query: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV---- 3804
+ K + HS+ + G R++K + L+ + D + +L++ T+
Sbjct: 4689 QHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSELRDKWDTICGKS 4745
Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
+ LE+ L + +F+D +AL W+ + L + ++ + +K+ Q+
Sbjct: 4746 VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQK 4805
Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
+ SV++++ L+E +D + +K ++ +L + ++ +C++ LEA ++
Sbjct: 4806 ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4865
Query: 3923 DHEDYNSELQEVEKWLLQMSGRL----VAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
E+++S + + +WL + L V PD + +L T+ Q HK M+++
Sbjct: 4866 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPD--DEDALRTLIDQ---HKEFMKKLEEKRA 4920
Query: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
LN GDT++ C +K + + + + + A++ Q L L
Sbjct: 4921 ELNKATTMGDTVLAICHPDSITTIKHWITI----IRARFEEVLAWAKQHQQRLASALAGL 4976
Query: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4091
+++Q+ L+ AWL + L + + ++++ +AL + +T+++
Sbjct: 4977 IAKQELLEALLAWLQWAETTLTDKDKEVIP-----QEIEEVKALIAEHQTFME 5024
Score = 320 bits (819), Expect = 5e-86
Identities = 790/4278 (18%), Positives = 1616/4278 (37%), Gaps = 541/4278 (12%)
Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1337
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 1034 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1093
Query: 1338 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1387
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 1094 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1150
Query: 1388 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1447
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 1151 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1209
Query: 1448 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1507
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 1210 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1265
Query: 1508 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1540
Q S F T E +I +L + G+ L+ +
Sbjct: 1266 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1325
Query: 1541 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 1326 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1378
Query: 1598 LCQAL-ESLSSAITAFS-----------ASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1645
CQ E S+ + + + + V R A + Q++ D+ +
Sbjct: 1379 ECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL----RT 1434
Query: 1646 RQTALENLLAHW--------QRLEKELSSFLTWLERGEAKASSPEMDIS-ADRVKVEGEL 1696
R TAL L+ + +RLE+E S + KA + +S + + E
Sbjct: 1435 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1494
Query: 1697 QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKR 1756
+ +S +K QL E+L ++ +L L + ++ D +
Sbjct: 1495 AGKPPFSKQKISSEEISTKKEQLSEALQTI---------QLFLAKHGDKMTD------EE 1539
Query: 1757 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESK 1816
N L+ V Q+ LL S S+ L E QT+ ++ + + ++ R +++ +++
Sbjct: 1540 RNELEKQVKTLQESYNLLFSESL---KQLQESQTSGDVKV-EEKIVAERQQEYKEKLQGI 1595
Query: 1817 KGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
L + L +G E + G E +++ Q L + +Q
Sbjct: 1596 CDLLTQTENRL-----IGHQEAFMIGDGTVE------------LKKYQSKQEELQKDMQG 1638
Query: 1877 HA-SLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKAL----ESAAVSLDGIL 1930
A +L+ +++ + E +++ + LIE+ LN+A + L E + LD ++
Sbjct: 1639 SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1698
Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL------------------------ 1966
+ A ++ T A QL +I+NLL
Sbjct: 1699 TTA--------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1750
Query: 1967 GTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2023
GT E D K A ++ E LL++ D + T +E L + ++ Q ++ +Q
Sbjct: 1751 GTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1806
Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT-------KRLIHE 2076
+ + + + L+ + + ++ ++ ++ + + L+V ++ +L H
Sbjct: 1807 HQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTHS 1863
Query: 2077 NQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
Q + E+++ + LEN A + T +K Q+ H+
Sbjct: 1864 LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG-- 1921
Query: 2133 NKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRL 2192
DL T G +L K D V T +V KL+ DR
Sbjct: 1922 --------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHR-----EVQRKLDHATDRF 1968
Query: 2193 RVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISNLDNHL------------RA 2233
R S + D++ E S + + + HL R
Sbjct: 1969 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2028
Query: 2234 EELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEIT 2292
E K + ++ ++ + +E+L L + +L D+Q D++ + E +
Sbjct: 2029 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2088
Query: 2293 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ---NETC--EALKKVKDIQK 2347
L+ +S V+ ++++ W VE SL Q N T + + K +++
Sbjct: 2089 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2148
Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
++ +QS+I++ E + + SL M L + S +T A ++E
Sbjct: 2149 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2208
Query: 2408 EK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
K E++ E + FL K A D G V E + +Q + + L+ +
Sbjct: 2209 TKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY-MQESTSEFLEHKKHLEVL 2266
Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
+ + +H + + E+ +++F+ + K+A+ C +L +F+ +
Sbjct: 2267 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2326
Query: 2527 LNLWIHEMEER-------FNTENLGESKQHIPE-------KKNEVHKVE---MFLGELLA 2569
L WI E ++ F E+LG+S + + K E+ KV + L L++
Sbjct: 2327 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2386
Query: 2570 A----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-----------HQNLLRMTKE 2614
A +++ + G +L+ EG E ++ LTS +++L + K+
Sbjct: 2387 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2446
Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
K+ L + + +E +M W++ + + T DT + Q+
Sbjct: 2447 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQN---KS 2503
Query: 2675 GEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLETLKEVWADIMSSSVHAQSTL 2728
E E+K N+ + + + L +E + L + W ++ ++ Q L
Sbjct: 2504 FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL 2563
Query: 2729 ESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDH 2786
E + + + QL+QW+ + + PL P + +Q +L E
Sbjct: 2564 EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN--TQRQQVQILLQEFATR 2621
Query: 2787 TRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDIMT-VAKEKMRKVEEIVKDH 2842
+L A + + + ED S + +E+L TQ D +T ++ +++ +
Sbjct: 2622 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2681
Query: 2843 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELI--DSREIGASRL 2897
Y + +D L +L +S A ++L K+K+ I + ++I ++
Sbjct: 2682 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQ- 2740
Query: 2898 SRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2956
+ E L+ VK+ E + E+ + L K ++D + ++ +++L S A S Q
Sbjct: 2741 ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2793
Query: 2957 EFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLEGKNTDEEIVECWHKGQEIL 3006
+Q F A L T ++ L +LE D + Q +
Sbjct: 2794 --------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2845
Query: 3007 DALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
AE LK+Q +E L+T K+ + +E L+
Sbjct: 2846 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV-----------KERENKLK 2894
Query: 3067 QRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNISEVST--SLQK-IQEFLSES 3114
+ KA + +Q W+ + + C D + + ++ SLQK + +
Sbjct: 2895 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2954
Query: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
E + N +LS E+ ++T E IQ KV E LH K+ LEN+ +
Sbjct: 2955 ELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-------LHSKKFCLENMTQK 3006
Query: 3175 MKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNR 3232
K+F EVS E + E++ +H+S L + LQ+ + + + Q++
Sbjct: 3007 FKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3063
Query: 3233 LKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3289
K AQ L + SK +V ++ ++ LS EK S L+ + F I
Sbjct: 3064 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3123
Query: 3290 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKLEALLSVKQEKEIQMKMIVT 3342
+E+ + LDS D L + KLEAL++ KM++
Sbjct: 3124 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3183
Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E TSP+ + I++ L+++ LL + Q+EG + + + +++FS
Sbjct: 3184 TEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3237
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSYSSLLETIEVKGAGM----- 3456
+ E + E L K+ EE+ + + G G+
Sbjct: 3238 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3297
Query: 3457 --TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK 3514
T + +L D+ R++ + ++ + + ++ + +Q L++ W+ +E
Sbjct: 3298 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3357
Query: 3515 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3574
+ + + +++ + LQ + ++ + + E + + P + + L+
Sbjct: 3358 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3417
Query: 3575 LR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNR 3631
L W+A ++ Q + + + + ++EWL T E+++ +
Sbjct: 3418 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3477
Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------DESHVNSRMG------CQA 3679
+ E Q+ Q K +++ + + + + Q + D+ V S++ +
Sbjct: 3478 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3537
Query: 3680 TQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
+ + LL Q L K F E+E++ + +W H ++ +
Sbjct: 3538 QEKSHSRSELLQQALCNAKIFGEDEVELM-----------NWLNEVHDKLSKLS--VQDY 3584
Query: 3739 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3798
T + K+ L VL +D+ + A G +K E ++ ++ + K
Sbjct: 3585 STEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3644
Query: 3799 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3858
++T TLE+ L LA+ + L W+ + + L E ++ E +
Sbjct: 3645 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3704
Query: 3859 YKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKIDQLQSDYQDLCSIGKEHVF 3915
K L++ +++ + S+ E ALLELV L+ + + Y+ + + V
Sbjct: 3705 PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3764
Query: 3916 SLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAG 3975
++A + + ++ W+ + +L++ + +T + QL K EI
Sbjct: 3765 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3823
Query: 3976 FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL 4035
+D +++L G ++ C++ + +K+ + L+ +Y IC Y LE
Sbjct: 3824 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----NYDTICQINSERYLQLERAQ 3879
Query: 4036 QKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS 4095
+T ++ WL+ Q + P P L + + R QE+ R +L+
Sbjct: 3880 SLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EYETLRQQQEEHRQLRELIAE 3932
Query: 4096 MCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--- 4149
+ KT + ++ + +I++K V A L + +IK + + L +A
Sbjct: 3933 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YSQIKEDVKKRAVALDEAISQ 3989
Query: 4150 --------DQQLQNMKRRHSEL--------ELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
DQ L++++R L E+ + +S+ K+ ++ Q T+
Sbjct: 3990 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 4049
Query: 4194 EKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCLQREE---DLQRTRDYHDCM 4246
++ ++ + + K + DQ + + + L +RE D+ + C
Sbjct: 4050 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 4109
Query: 4247 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ------ 4300
++ + K T ++ D E + +K+ A + + I+ L+++
Sbjct: 4110 HMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4165
Query: 4301 -KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4359
++I DK +VK+ L W L K +I ++ Q Q + +W
Sbjct: 4166 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4225
Query: 4360 AEEQQPNIA----------------EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4403
+ +A E LKQ Q + M+ L +EL LLK
Sbjct: 4226 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL-----LLKK 4280
Query: 4404 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4463
+ +++D+ +Q L + + + L + + R+ L AL QF A+
Sbjct: 4281 VTEESDK----------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4330
Query: 4464 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE 4523
+ + + E + ++ + P + ++ Q + +Q+ V + G +L++
Sbjct: 4331 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4390
Query: 4524 VTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI 4583
+E S + KL+ L + +VL+K R Q+L+ L K F + + WL +
Sbjct: 4391 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450
Query: 4584 VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSE 4643
L QL + + E +L + GQ +L + + + +
Sbjct: 4451 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4510
Query: 4644 KLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD 4703
+N L ++ + ++ K++EA+ E+ + ++ L++ E Q L ++ P+
Sbjct: 4511 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE-QTLNVASRPS- 4568
Query: 4704 LAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ----PDKMLHLVTLY 4759
L ++ L D + +EV E + EL++ + Q + ++ + + +
Sbjct: 4569 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4628
Query: 4760 HRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 4811
++ ++ +R L+D A Q HE K+ + LE KS+ E N+ +T A
Sbjct: 4629 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4688
Query: 4812 EEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK 4866
+ K L HS+ + +G LK T +D K + + +
Sbjct: 4689 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---------KLDDMLSELRDKWD 4739
Query: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG--PVYLDLNLQDIQEEI 4924
+ E + E ++ S F + +DWL RV+ +L+ PV+ D++L + I
Sbjct: 4740 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL--VMNLI 4797
Query: 4925 RKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4984
+ Q+E+ + AL +E +++ S+ ++ + ELS + ++
Sbjct: 4798 DNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKVQMQELSTRWETVCALSISK 4856
Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL-KSHMEFFSTED 5043
Q L Q + ++ V A +WL +A++ L+ G D E A L H EF +
Sbjct: 4857 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4916
Query: 5044 QFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQKVASLELRSQRMSRDSG-- 5090
+ + L + ++ T+ + P + E+ +A + QR++
Sbjct: 4917 EKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL 4976
Query: 5091 -AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEK 5141
A+ +LL+ A QW + K +E + + + + + ++E F T + ++
Sbjct: 4977 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5036
Query: 5142 LSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGNDASKATLSRSMTTVWQRWT 5193
+K + +S I L++ AS L +G+ T + + + +W
Sbjct: 5037 TKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQ 5096
Query: 5194 RLRAVAQDQEKILEDAVD 5211
++ +A ++ + L DA+D
Sbjct: 5097 QVWLLALERRRKLNDALD 5114
Score = 318 bits (815), Expect = 1e-85
Identities = 900/4830 (18%), Positives = 1875/4830 (38%), Gaps = 684/4830 (14%)
Query: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
V+ W+D M+ L+ +E ++L + L K ++ + + S L+ ++ MT
Sbjct: 637 VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 695
Query: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
L+L ++ +R + AK T + L LH R +WL +++E+
Sbjct: 696 ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 750
Query: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
Y E + + H +R+L + + + Q + +L P+ +
Sbjct: 751 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 807
Query: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
RA + W Q + + E F ++ ++L+ ++ +
Sbjct: 808 YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 859
Query: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
+ R S+ E + + + EE+ Y+ + + +A+ I+ NS + +
Sbjct: 860 KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 919
Query: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
+ Y+ + + + + + + + ++ S +E+ + S +K +
Sbjct: 920 PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 979
Query: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
+A +I++ + + TL + +K + H L+ R ++K + GE
Sbjct: 980 LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 1034
Query: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
++ L+ D +E +E + LEK +++ K++ YQE+L
Sbjct: 1035 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 1081
Query: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
E + E +S+ ++++ + + E ++ +R + E++ + + L
Sbjct: 1082 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1141
Query: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
K ++++L+ D + + +E FS A SEL V + + Q MS + D
Sbjct: 1142 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 1198
Query: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
L+T +L Q A + + EE A D+ NN++ TL Q + K +
Sbjct: 1199 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 1255
Query: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
Q HA L+ AI + Y+ + + H + D L + W + VQ D
Sbjct: 1256 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 1310
Query: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
L E I K +K++R ++ V+TT + IQ+ + +T
Sbjct: 1311 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1355
Query: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
+ +L Q + L EI+ +S++ + A+Q +K EL+ + MV +
Sbjct: 1356 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1410
Query: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
K + Q+S + II++ L + + + L Q++ S + E+ L+
Sbjct: 1411 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1465
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
+ H V K +W S+ T E K + Q K + E++
Sbjct: 1466 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1512
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
+K+++ E L L K ++ +LE +K T E N++ F E +
Sbjct: 1513 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1562
Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
+ +E Q + +++ + Q IC L + LI + M G
Sbjct: 1563 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1619
Query: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
E + Q +++ L K + Q L V + T + + +
Sbjct: 1620 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1661
Query: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
+E L+ +++ C+ Q +LK Q++ +EL K VT E EK
Sbjct: 1662 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1711
Query: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
+ +L+E ++ +++L K S R K ++ + HF+E + D+
Sbjct: 1712 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1771
Query: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
L + D+ N + + A+++ I+ Q ++ + L++ GQ + P
Sbjct: 1772 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1831
Query: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
E L + + L + +A ++ K + +QE + E+ ++ + Q
Sbjct: 1832 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1887
Query: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
L LEA ++ + T L E+ +S + R I + EA +++ G
Sbjct: 1888 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1947
Query: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
T + K+ H + L + + L+D YQ +E L L++ +
Sbjct: 1948 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2007
Query: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
SK E + + K L+ +L G + + LK+ L D L P A
Sbjct: 2008 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 2066
Query: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
+ + G + L+ ++ E + + + +S+ Q + LDW+ V++ L
Sbjct: 2067 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2126
Query: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
+ LN +Q+ I K + ++++ +NA++ K K+ ++ L+ + +L
Sbjct: 2127 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2186
Query: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
S + + A + E+ ++ + + + + +LE Q L ++ G DV
Sbjct: 2187 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 2244
Query: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
L +M+ ++E H +LE LHSL+ + P+ K + +K +L + + M
Sbjct: 2245 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2302
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
+ + + C Q +Q + + + +T KK+ F S E +KL E
Sbjct: 2303 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2362
Query: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
+L +S V + + I A++ + L E T + + ++
Sbjct: 2363 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2422
Query: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
+T++ + T + +D +L+D + E +K++KA E M+ LQ
Sbjct: 2423 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2482
Query: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
+ P + +A K T +E + +F EL+Q + + L+ + +L++ P E P
Sbjct: 2483 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2536
Query: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
Q +T + + + + + +++ + +T +K W+ E + LG
Sbjct: 2537 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2596
Query: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
+I+ ++ Q +++QILL E + E++ + G+ + + SL Q
Sbjct: 2597 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2652
Query: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
LA V + Q+ D+ ++Q+ S Q Q L + L+ L+ L K + +
Sbjct: 2653 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2708
Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
T + ++L+ E+ ++ L + L L++++ + +
Sbjct: 2709 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2768
Query: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
+ ++AEN + L A + ++ +M W++ K N + + +
Sbjct: 2769 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2822
Query: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
+ ++L+++ K+ L A + + + E + + G E L+ + N
Sbjct: 2823 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 2878
Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
K +K+ E +LK+ +LE+A L KEQ+ + L ++ + +
Sbjct: 2879 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 2921
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
+ ++ C E+ +A L LQ+E QH + + +++ +
Sbjct: 2922 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 2972
Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
E E K L Q ++ ++ K N+ QE+ + R + A++ +
Sbjct: 2973 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3032
Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
+ S K LTM L + LA+ GT D+ ++
Sbjct: 3033 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3092
Query: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
H ++ +C L + + + T E+ S A S +PV ++ +
Sbjct: 3093 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3152
Query: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
A+ + L A D A + E P L L L + L +
Sbjct: 3153 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 3211
Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
++ + ++R +++ L+ S I L+ +E E + P E++ Q M
Sbjct: 3212 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 3266
Query: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
++ ++EI LQ L + L+ + ++ + L+ L + R T+ K
Sbjct: 3267 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 3323
Query: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
+ + L+E L L R + AL+ L SW++ T+ + P E ++A
Sbjct: 3324 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3373
Query: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
Q L+D + VE+ KV L +LS+ + L KA
Sbjct: 3374 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3433
Query: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
T++ R+L+G + Q+ H+ + LN T EK + + TQ+ ++E
Sbjct: 3434 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3483
Query: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
+AQ + + K L Q ++ +SL + ++SR ++ ++Q E
Sbjct: 3484 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3538
Query: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
+ + ++L Q L K ED++ M W +H Q++ST+ Q + L
Sbjct: 3539 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3596
Query: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
QE +L + N LL+G+ L K + + L+ + +++++ S +
Sbjct: 3597 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3655
Query: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
Q++ L ++L+ TWLD VE L + L EE + L K+ K
Sbjct: 3656 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3715
Query: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
+D + N S A E G + V ED R L+ + Q+ ++
Sbjct: 3716 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3769
Query: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
+ + + F+Q ++ I + E L +E
Sbjct: 3770 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3803
Query: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
+ +LQV++ E+ + +D+ D+L+ + ++ ++K + ++ L++
Sbjct: 3804 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3863
Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
+ + E+ E Q L+++ E ++ L LTET + IIS
Sbjct: 3864 ICQINSERYL--------QLERAQSLVNQFWETYEELWPW--LTET--QSIIS------- 3904
Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
+L A A LEY ET QQE RQL L+ E
Sbjct: 3905 ----QLPAPA-------------LEY--ETL----RQQQEEHRQLRE---------LIAE 3932
Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
++ + +N+ P+L + L G+ I ++ +Q+ E
Sbjct: 3933 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 3974
Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
+ K L+ + T++ + ++ L+ +RL +Q ++ E+E +++ ++
Sbjct: 3975 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 4029
Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
S +++ L ++ G +++ K + ++ +L ++ W ++ T +
Sbjct: 4030 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4089
Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
+ KL L + +L + MS I +++ D I + + + +
Sbjct: 4090 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4146
Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
+ +I+ Q +D V + + S+ + + DK + + +N +W L ++I
Sbjct: 4147 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4202
Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
LE +++ +Y++ +Q + W + +L IG D +V+ +++ + +
Sbjct: 4203 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4262
Query: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
++ E+E++ L++ E+ V L EL W +L+ + + L+ L
Sbjct: 4263 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4322
Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
+ A D++ ++L LS + + G +A+++++ LQ+D+ + +++
Sbjct: 4323 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4382
Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
N L++ L N L+ +N RW N+LE+ ++ Q L+ + K + +
Sbjct: 4383 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4439
Query: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
Q D LL + + A +++ ++ C T K L + G+Q
Sbjct: 4440 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4495
Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
+ + SA + I D +L + ++E L +++T L+ + F SL+ W+
Sbjct: 4496 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4555
Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
+AE+ L S L T+ +++E K + +S + L++ G L +++
Sbjct: 4556 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4614
Query: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
++NL W + + ER L + + F E ME+L ++E+ L +
Sbjct: 4615 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4674
Query: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
EI+ + + Q H+ FQ + ++ + + G+ L E+ + DD + + L+ L
Sbjct: 4675 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4734
Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
++W + ++ +R+ ++ + ++ + + L WL V ++ V +
Sbjct: 4735 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4793
Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
L D K F ++ G +V+A K+ L+ + ++ ++ E+ +W++
Sbjct: 4794 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4849
Query: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
++ +L L+ E+ + LE L ++ L LPD + L + K
Sbjct: 4850 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4909
Query: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
E + +L + + + DT+ A D I+ + + +++ ++EE+ +Q++
Sbjct: 4910 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4969
Query: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
L E + L WL E+ ++ +I + IE++K + + EE+
Sbjct: 4970 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5029
Query: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
Q + ++ + +R A SH ++IE K +VN
Sbjct: 5030 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5089
Query: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
+WQ + L R +KL + L +++L
Sbjct: 5090 LLVSKWQQVWLLALERRRKLNDALDRLEEL 5119
Score = 298 bits (763), Expect = 2e-79
Identities = 728/4019 (18%), Positives = 1555/4019 (38%), Gaps = 470/4019 (11%)
Query: 4948 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 1137 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1196
Query: 4999 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 5043
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 1197 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1256
Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5097
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 1257 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1316
Query: 5098 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5155
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 1317 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1373
Query: 5156 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5213
K+ ++ A Q T D T++ R+M Q+ + R + + I+++ +D
Sbjct: 1374 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1433
Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
T + V T+ I D L E+ S E + H EL++ S +
Sbjct: 1434 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1486
Query: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5327
+TL + P ++ +EI+ +++ + + K K+ +E + E
Sbjct: 1487 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1546
Query: 5328 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5387
V+T S E+ + L D ++EE + + + +E KEK G
Sbjct: 1547 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1594
Query: 5388 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5430
+ +L + + + + ++LK Q+++++ Q A T L
Sbjct: 1595 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1654
Query: 5431 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
+KL+++ + L + K K + + ++A+ +K L + + + E AAV++
Sbjct: 1655 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1714
Query: 5486 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5539
E ++ L + K +E H+Q I Q + S + E +E+ +
Sbjct: 1715 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1773
Query: 5540 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5596
L+ +V GT N Q ++ H+ ++ + + + + + EK S
Sbjct: 1774 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1830
Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
EK+ + + EL E + +++ ++++KF+A+ + + L+Q++ L
Sbjct: 1831 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1890
Query: 5657 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5705
+ E G LK Q S + ++S L+ + ++ +S + V +
Sbjct: 1891 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1950
Query: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5761
R + A+ + +CN++ + V +Y+ YE L
Sbjct: 1951 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 1999
Query: 5762 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5819
+ +Q +A S+H E +A K Q Q+ + ++ + ++ + V
Sbjct: 2000 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2047
Query: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5867
+++ AE D G LLP + + GR L V E S ++
Sbjct: 2048 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2107
Query: 5868 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5919
G N E S + P ++++I Q ++ + +A ++
Sbjct: 2108 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2165
Query: 5920 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5979
E +P S AK+ DL + + E + E + + +++ + + T +
Sbjct: 2166 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2225
Query: 5980 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 6039
E L+E PG+ Q E L + + E+ SL +E+ S +D A
Sbjct: 2226 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2284
Query: 6040 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6089
L + L+ + M TI+ K Q+L + L ++E ++ + +
Sbjct: 2285 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2344
Query: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
A++L L TK + E + + N++ + A++ +V +
Sbjct: 2345 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2402
Query: 6150 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6206
+L G+ + E A K L +K + ++ D L ++ E S +
Sbjct: 2403 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2462
Query: 6207 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6255
+S + +WL + T T+ +Q+ ++Q K E EL + + ++ + +
Sbjct: 2463 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2522
Query: 6256 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6299
E+L E + D E P D QEL + E+SS
Sbjct: 2523 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2576
Query: 6300 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6337
E+ +++ +++L+ +VL +++Q Q+L Y + G+
Sbjct: 2577 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2636
Query: 6338 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6394
G+ P+ + V L + Q ++ ++ Q Q+I + + + S L
Sbjct: 2637 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2695
Query: 6395 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6454
D++ +L + A+ T NQ++ + + +K + +QA E+ V
Sbjct: 2696 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2751
Query: 6455 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
E+ L L R +L S V Q+ + LQ + + + ++ +K
Sbjct: 2752 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2809
Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6558
P++ +++ ++ K+F + +K E ++
Sbjct: 2810 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2869
Query: 6559 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6617
+L+ ++ +D + R + L ++L +Y+ ++ L ++ Q + + +
Sbjct: 2870 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2929
Query: 6618 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6673
++ E I +L KE Q +L T + + KE T + L+ + V
Sbjct: 2930 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2989
Query: 6674 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6730
++ H + LE + + + E +E RQL+ + + S+G + L T
Sbjct: 2990 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3045
Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6786
+ Q + SL + ++ + L++ S SD+ Q+ + + + + ++ ++
Sbjct: 3046 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3105
Query: 6787 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6846
LET L+ +Q+ ++ D L+ V ++ E ++ F
Sbjct: 3106 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3161
Query: 6847 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
K+++A + + T +L ++ D ++ +L + Q LL A +E++
Sbjct: 3162 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3221
Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6960
+ +L + S++ + L++ + +E + + I++ L +K F+ + +
Sbjct: 3222 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3278
Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
KQ V+++ Q ++Q +++ ++ + L +N W+ L V ++ L+
Sbjct: 3279 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3333
Query: 7021 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
L +++ ++ L +W +T+E Q+ + V+ +++ + L+ L+ ++ VE
Sbjct: 3334 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3393
Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
I++ G + + ++ L L W L + L+ +
Sbjct: 3394 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3453
Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7199
+ +N +L L + ++ Q+ + L+DD+ + L + SI Q LK
Sbjct: 3454 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3512
Query: 7200 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7245
+ + + + + W EI E+ S LLQ +
Sbjct: 3513 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3569
Query: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7300
+ S + Q+ T L K + + +++ Q+ + LL GL +K D +
Sbjct: 3570 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3629
Query: 7301 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7354
+ + E +K + + A ++ L L++ L + + LC ++ +L Y
Sbjct: 3630 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3688
Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
ET ++L+G++ S + Q R +ELK + ++ LD LN
Sbjct: 3689 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3723
Query: 7415 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7468
E+ L P +E K + N + L+S T++ ++ + +L+ Q F + +
Sbjct: 3724 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3783
Query: 7469 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7526
+ ++ +TE+KL +I Q + + F E+ + I+ ++ G +++
Sbjct: 3784 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3843
Query: 7527 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
+++ KL + + + + +R ++ ++ E E+L WL E +
Sbjct: 3844 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3902
Query: 7587 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
+ +P P + TL + + ++ + + +I + LL G
Sbjct: 3903 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3953
Query: 7645 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7701
E IQEK+ +A +++E KK A L + D ++++ +++ + L
Sbjct: 3954 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4012
Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7750
+ AE + KE + + + D+ +L L +TL A D I +
Sbjct: 4013 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4071
Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7810
++++ + WE + + R ++ + + F + L + + + D
Sbjct: 4072 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4131
Query: 7811 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
I+ + K +++ +EEI QE + +G L A E ++ + ++N W
Sbjct: 4132 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4191
Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7924
L R+ KL+E + A Q + ++ W+ +LA PI D E +++
Sbjct: 4192 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4248
Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
++ E ++ + + + + + + E+LL +++ ++Q L W ++
Sbjct: 4249 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4305
Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
+ R+ K+E +F WL +E + G + EL K
Sbjct: 4306 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4365
Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
Q V + +E +NK L + + A +L+ + NQRW N+ ++ ++L
Sbjct: 4366 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4425
Query: 8105 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8164
+ Q + F + + WLT+ + L + AK +QL + + K E
Sbjct: 4426 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4484
Query: 8165 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8221
++ +G+Q++ + I+++++ L+ + V E
Sbjct: 4485 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4525
Query: 8222 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
L++R+ +LE++ L+ + +H+ D + Q L+++ L +D+
Sbjct: 4526 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4573
Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD-----HSALESQI 8335
+ + D + ++ S + + D+ G K F + V L + S E +
Sbjct: 4574 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4632
Query: 8336 RQL---GKALDDSRFQIQQ--------TENIIRSKTPTGPELDTS------------YKG 8372
++L G++LDD+R + +Q E + S+ EL+ + +K
Sbjct: 4633 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4692
Query: 8373 YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 8432
+ K LG S D+ R LKE+ + L + + + D+W+ + +++ ++
Sbjct: 4693 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVERQ 4749
Query: 8433 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8492
++++ L QF L ++ WL E +L + Q + DI + I K QK +
Sbjct: 4750 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKEL 4807
Query: 8493 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
R + + ++ + E + +S ++ ++ +++ RW+ VC+L + L+ AL Q
Sbjct: 4808 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4867
Query: 8553 QGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
+ FH + H LL L ++ R + ++P D + L D HK+ M+ +L E + +
Sbjct: 4868 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELN 4923
Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
M +L K + +I R + +L +H + L L ++Q+L
Sbjct: 4924 KATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4982
Score = 290 bits (741), Expect = 6e-77
Identities = 817/4617 (17%), Positives = 1774/4617 (38%), Gaps = 529/4617 (11%)
Query: 1370 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1427
S L S+ S LE K + E E+ +KEA SEI + K ++ ++ Q
Sbjct: 658 SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 713
Query: 1428 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1487
KL +T + ++ + +F S +W+ EKE+E A + S + I++ K
Sbjct: 714 AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 767
Query: 1488 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1541
++E++ K +I ++E A+ Q + AR I+A ++ + + Q
Sbjct: 768 DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 824
Query: 1542 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1596
C+E H+ + + E +++ + K A+ K C ++ +K+ +QE M
Sbjct: 825 CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 880
Query: 1597 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1646
+ + L S I A+ ++ N D ++ + ++ +Q E + + E
Sbjct: 881 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 940
Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1705
A + A W+ + + + + E A+R+ E + Q + L +E
Sbjct: 941 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 998
Query: 1706 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1754
VVS +++ +++ S +VAS +K M + L L R+ D +
Sbjct: 999 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1050
Query: 1755 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1814
+ +S V +L +V K + EL ++E + V + + +EV
Sbjct: 1051 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1102
Query: 1815 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1873
+ + L++ + L + + + +DLH + + +L +E ++ + + EF
Sbjct: 1103 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1162
Query: 1874 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
A+ S + L + Q + SM+ D + K +N L+N +A E A V L
Sbjct: 1163 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1219
Query: 1928 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1984
Y K+ E + + I+NL+ T + SE D + A +
Sbjct: 1220 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1262
Query: 1985 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2038
D+ ++ K+I D +T KER KE Q +++ V Q+++ L L
Sbjct: 1263 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1314
Query: 2039 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2094
+ K + + P +D I ++E T +R I ENQ + + Q +
Sbjct: 1315 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1369
Query: 2095 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
+ SK+ E T+KD E + ++ K K++ + S ++
Sbjct: 1370 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1426
Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
E + + +LV T M + D ++LEE L + + E++ W
Sbjct: 1427 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1482
Query: 2214 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2260
+N P + IS+ + + E+L + ++ A +++ + N+
Sbjct: 1483 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1542
Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
L++ K L+ +L F E+ +++L+ ++ +V K K + + ++ + I
Sbjct: 1543 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1599
Query: 2321 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
T+ E L+ + + LKK + Q+ELQ + + + E
Sbjct: 1600 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1659
Query: 2377 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2430
L + LI K +EA QL K + S +E L+K + +++E E K +
Sbjct: 1660 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1718
Query: 2431 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2457
+ S+R G +V+E Q N+L++
Sbjct: 1719 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1778
Query: 2458 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2487
DGQ S+ AV TQ Q L +LS + +Q+
Sbjct: 1779 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1838
Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
+ + ++ L + K + EL F+ + + W+ + E+ ENL
Sbjct: 1839 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1896
Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2605
I ++ + + F S D +S +G L ++ G+ + + CS+
Sbjct: 1897 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1947
Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2661
+ +E R A +L + +K + D+ E L E
Sbjct: 1948 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2007
Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
S+ + ++ + K Q SS + ++ E L + ++ +
Sbjct: 2008 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2067
Query: 2722 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
Q TL+ ++ ++ D + N+ E + + L Q GL E + +++S L
Sbjct: 2068 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2124
Query: 2782 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2818
E ++ AL +I+K+ L + +T D S + Q ++K
Sbjct: 2125 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2184
Query: 2819 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2874
+F++ KE + K+EE+ ++ + + +L + + L D +
Sbjct: 2185 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2244
Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
+Q E ++ ++ L + SL E+ + S L+ + L +K+ E
Sbjct: 2245 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2300
Query: 2935 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2973
D++ + + SC E L ++ + + F + L ++LE
Sbjct: 2301 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2358
Query: 2974 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
L + W+ + L+ T + + G +L+ + TE+
Sbjct: 2359 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2417
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+ L +D++ S L L L+ N + Q+ ++ QW
Sbjct: 2418 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2471
Query: 3080 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3136
L +N T + P + V T +++ + F +E + +K+ + K ELL
Sbjct: 2472 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2531
Query: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
+A + +T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 2532 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2591
Query: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3252
D ++Q++Q +L+E +PQ +L Q + S R
Sbjct: 2592 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2651
Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
+++ ++ ++ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++
Sbjct: 2652 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2711
Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3371
++ + + + Q+++ Q+K+ E + E + + +QL+ + +
Sbjct: 2712 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2771
Query: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
+ L+ A + +Q R F W+D+ + N+S A+L +++
Sbjct: 2772 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2831
Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3485
K ++ + + S + E +G + +E QL+L ++ + ++ KE
Sbjct: 2832 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2891
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEG 3545
K ++ + +Y+ ++ W+ + Q L++ A E ++ L+ LQ +
Sbjct: 2892 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQH 2950
Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLR 3601
++ + +T ++ + + + + +SL Q +L + N+ K +
Sbjct: 2951 FGMVELLNNTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3008
Query: 3602 LMEQKFQQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEE 3657
++ ++ L+ A+E++ S ++ SN+ +Q Q + + A + +V+
Sbjct: 3009 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDL 3063
Query: 3658 VGARAQEILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
AQ+++ E S S + Q + + L QV E+ FLE ++Q + ++++
Sbjct: 3064 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3123
Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
+ ++A +T+ K+ +T++ LK +E L ++ + +
Sbjct: 3124 REMFSQFAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKT 3177
Query: 3775 VKYLEEGEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
K + E +++++ +Q +L + +E + +EF K K +
Sbjct: 3178 CKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3237
Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQ 3888
+ + +E ME QL+ +K Q+ + + + V G+ L++
Sbjct: 3238 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3297
Query: 3889 DVT----LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
T L+ +D + + ++ L + L+ + + L+ + W++
Sbjct: 3298 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-E 3356
Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
LVA ++ + + Q+ K + + + + ++ +G+ + A + K
Sbjct: 3357 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKV 3412
Query: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
+ L + A+ + A+ + LE +TL+ WL+ ++ L
Sbjct: 3413 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3472
Query: 4065 PPLSRAEAIKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNA 4102
++ +Q+ +AL++ +R D++ S D S
Sbjct: 3473 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQV 3532
Query: 4103 SVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRR 4159
+ + ++Q L A+ + E+ + +E+ L D + + ++
Sbjct: 3533 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3592
Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
SEL V Q ++K QA +N + E + + T E ++ + ++
Sbjct: 3593 QSELR-------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYK 3644
Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVH 4274
D+ + S ++ E+ LQ R H C + +V +E + E L +A +
Sbjct: 3645 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3704
Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
+ LKK A + K ++ L + ++E + +E +++ + +R+ + D I +
Sbjct: 3705 PKELKKEA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3761
Query: 4335 KIQ-VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
K++ + L Q+ EL W E + + D L E
Sbjct: 3762 KVEEIDAAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3820
Query: 4394 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4453
+ + ++ L+K ++M E+Q ++K L + + + + +R L +A S
Sbjct: 3821 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3880
Query: 4454 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4513
QF + + + + I L + + +Q + + + + ++ + +
Sbjct: 3881 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3940
Query: 4514 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4573
G +L+ E++ E + K ++Y + + R L++ + F + D+
Sbjct: 3941 NKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3999
Query: 4574 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
L++ ++ E ++ Q+++ +N+ + + L TL++ G+ ++
Sbjct: 4000 ILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4059
Query: 4634 NEVDHSY----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLS 4688
D + +KL+ + + I L +++ K+ + + LA K + + L ++
Sbjct: 4060 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIK 4118
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPW 4747
+ + F+R + P + Q+ I +E+ GL E +D +N E + G+P
Sbjct: 4119 DTQ-DFIRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD 4176
Query: 4748 QP---DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
+P + L + + L + + R+ LE+ A +++ Q + + + + +
Sbjct: 4177 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4236
Query: 4805 NE-----ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQI 4858
+ ET+ + E+LK + S A Q I ++R+ E L L + E +H +
Sbjct: 4237 SPIGTDLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTV 4290
Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLD 4914
Q ELKL+ ++ E + + ++ ++ FQ + L WL + LS +
Sbjct: 4291 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4350
Query: 4915 LNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD 4974
+ + I+ E+ K + Q +V + + A++ + + +++L++ L L++
Sbjct: 4351 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4410
Query: 4975 GDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENL 5032
++ E R+ L Q + ++ + WL D + L LA L E+A+E L
Sbjct: 4411 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQL 4469
Query: 5033 KSHME----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
HME F + E+ + S +++ ++A + + +++Q + +L+ + + +
Sbjct: 4470 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETK 4525
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEH 5145
+ L+ ++ + ++ I + E+ L S SL+ + + + EH
Sbjct: 4526 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEH 4581
Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
K + VNS E+I+ L++ + L+ + + +V RW ++ ++ +
Sbjct: 4582 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4641
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
L+DA F+ K E +++ + L ++ T L H F L +
Sbjct: 4642 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4701
Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKD 5324
S + S+ E+ L + + D +++K T GK V+++ K
Sbjct: 4702 SVYDTTNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKL 4752
Query: 5325 REMV------ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKM 5377
E + + ++ W+ Y P + D + ++ +++ NH+
Sbjct: 4753 EEALLFSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK------ 4801
Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
+K LG T S+Q AL R+ I+ + K QELS + + +
Sbjct: 4802 ---AFQKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4849
Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
+ T+L+A EE L+E A ++ L +G L
Sbjct: 4850 CALSISKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD- 4897
Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHG 5552
+ L + H++ +++ E + ++LN+A + + + + + I WI +
Sbjct: 4898 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 4957
Query: 5553 TIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRE 5612
+AW Q R L + ++ LEA+ LQ+ + T+K + + + E
Sbjct: 4958 VLAWAKQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---E 5008
Query: 5613 TEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
EE++ +I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 5009 IEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5065
Score = 235 bits (599), Expect = 2e-60
Identities = 796/4534 (17%), Positives = 1666/4534 (36%), Gaps = 676/4534 (14%)
Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 620 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 675
Query: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 676 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 721
Query: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 722 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 776
Query: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 777 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 827
Query: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 828 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 886
Query: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
+S + + + +T+ + +I ++ AN
Sbjct: 887 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 946
Query: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
+A K C ++ E Q++ L LW HE
Sbjct: 947 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1005
Query: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 1006 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1059
Query: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 1060 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1112
Query: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 1113 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1171
Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 1172 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1226
Query: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 1227 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1282
Query: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 1283 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1342
Query: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 1343 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1400
Query: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 1401 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1446
Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
+ D+L++ E + L+ + E +++L + +S
Sbjct: 1447 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1487
Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 1488 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1541
Query: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601
Query: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 1602 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1661
Query: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 1662 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1716
Query: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 1717 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1776
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 1777 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1833
Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 1834 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1893
Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
++ T L + K +E+V+S+ L I + G + E
Sbjct: 1894 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1953
Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 1954 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2013
Query: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
+ + D + L + + LQ + Q + + T E D S +P
Sbjct: 2014 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2068
Query: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
D + L+ + ++ ++E + + + ++ ++ +W+ E + + +
Sbjct: 2069 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2128
Query: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
N + + + +++ + + + + ++ ++ + ++ QA L++
Sbjct: 2129 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2188
Query: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
R+ + L +++ L+ +++ E L ++ + + ++
Sbjct: 2189 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2248
Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
M + LE K +E HSLLK G + K L + L K + KE+
Sbjct: 2249 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 2300
Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
T++++ + F K+L WI E + + + +P + L K
Sbjct: 2301 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2359
Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
LQ+ P ++ V G +L L+ VT
Sbjct: 2360 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2419
Query: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
+K + + Y+DL + K+ + L K+ + E + +WL +M+
Sbjct: 2420 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2479
Query: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
P +T +++T +Q K
Sbjct: 2480 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2539
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
M+ EI LN L + + + +++L +A+LKQ + + G
Sbjct: 2540 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2599
Query: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
+ +T ++ Q L LQ+ +R+ +Q A A Q L + P R +Q+
Sbjct: 2600 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2653
Query: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
A+ ++ + L CD + A VK+T Q +++ KL N +
Sbjct: 2654 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2708
Query: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
+ L+ A + Q +++ +++ +AQ + + VK+ + +A ++ +E
Sbjct: 2709 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2765
Query: 4196 VNKLTKKEESPEHKEINHLN----------------DQWLDLCRQSNN------------ 4227
+ K K E + HL WLD ++ N
Sbjct: 2766 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL 2825
Query: 4228 -LCLQREEDLQRTRDYHDCM--------------------NVVEVFLEKFTTEWDNLARS 4266
++ +D +T M +++ L T WD +
Sbjct: 2826 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2885
Query: 4267 DAESTAVHLEALKK--------------------------LALALQERKYAIEDLKDQKQ 4300
E E+L+K L E + +I LK ++
Sbjct: 2886 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK 2945
Query: 4301 KMIEHLNLDDK------------ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4348
+M +H + + E+ KE + + Q D++ ++ LE +
Sbjct: 2946 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT- 3004
Query: 4349 VQSRFQELMEWAEEQQPNIAEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIK 4406
+F+E E ++E + + A +Q D +Q +L + + LK +
Sbjct: 3005 --QKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3062
Query: 4407 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4466
A R+ DL V++ + S S V + + Q L++ + EK FL Q
Sbjct: 3063 LAKRLAQDL------VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3116
Query: 4467 SQIQQHERKI--MFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMK 4522
Q R++ F E L V + +T + + ++K + ++ L A K
Sbjct: 3117 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3176
Query: 4523 E-----VTEQEKSEVLG---KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4574
TE+ +++G L+ L + +L + R +++E + + F +
Sbjct: 3177 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3236
Query: 4575 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILP 4631
L++A+ + + E+ ++ QL ++ + Q E E L Q GQ ++
Sbjct: 3237 SILLQKAEEHEESQGPVGMETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQ 3294
Query: 4632 S-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4690
S L L+ + ++ + + ++QEA+L + +E + +
Sbjct: 3295 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3354
Query: 4691 EAQFLRMSKVPTDLAVEEA-LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQP 4749
E + V +A + Q + +LD+ V+ + ++ E +T +P
Sbjct: 3355 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADK 3411
Query: 4750 DKMLHLVTL----YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4805
K+L ++L + L + E R LE + Q+ + + L L ++ E+ VN
Sbjct: 3412 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVN 3469
Query: 4806 EETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS---- 4860
E + + KL+ + +L+D I + + L L+ + + +QS
Sbjct: 3470 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3529
Query: 4861 ---WQGELKLLTSAIGETVTE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL 4915
W E++ + + E + + C +++ F + ++WL V +LS D
Sbjct: 3530 SQVWYIEIQEKSHSRSELLQQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDY 3584
Query: 4916 NLQDIQEEIRKIQIHQEEVQSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELS 4971
+ + + ++ ++++ QE++ LR N L+ E K T E++ ++ L +
Sbjct: 3585 STEGLWKQQSELRVLQEDI--LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIK 3640
Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEE 5030
DI + TL + +R + + WL+ + ELL L E A +
Sbjct: 3641 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3700
Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSG 5090
E + L+ L+ + + L L+ +E LE+ VA R + +S
Sbjct: 3701 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3760
Query: 5091 AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
+V+ + + + +A + + + +TEKKL ++ + +L K
Sbjct: 3761 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTM 3819
Query: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
+ + I L + ++ ++ K ++ + + V + + + + ++ LE A
Sbjct: 3820 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3879
Query: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
F ++ + + Q + A L E H + + + +
Sbjct: 3880 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3939
Query: 5271 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5330
+ + +L+ +PGE + ++ A ++E VK + + +
Sbjct: 3940 MNKTGPQLLE----LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3995
Query: 5331 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEK 5384
+I+ + ++ E L P I A++E+++ ++E N ++EK+ +++ E+
Sbjct: 3996 KIDQILESLERIVERLRQPP-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4054
Query: 5385 YLGLYTILPSELSLQLAEVALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
+ ++S + + LD + I + I ++E E EL+ +K D
Sbjct: 4055 MIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHM 4111
Query: 5443 TILTKLKAKTD-------------NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ 5489
+++ +K D V Q + + + EE+DG +L + + +
Sbjct: 4112 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 4171
Query: 5490 NGQLGKPLAKK-IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 5548
G+ KP+ KK I +L + ++R+ KL +A +Y + L+ + W++
Sbjct: 4172 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD---- 4227
Query: 5549 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
+A G +A S S + + +EE K+ S EA ++++ E+++ Q
Sbjct: 4228 IAGGKLA--SMSPIGTDLETVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAEL 4276
Query: 5609 LGRETEELRQMIKIRLQNLQDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L ++ E + +QD ++K E + Q LE A L +
Sbjct: 4277 LLKKVTE-----ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4331
Query: 5665 LKEQLSHRQHLLSEMESL--KPKVQAVQLCQSALRIPEDVVASLPLCHAALR-------- 5714
L L+H + LLSE + + PK ++L + + + DV+A A +
Sbjct: 4332 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIES 4390
Query: 5715 -LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------- 5763
EEAS LQ+ Q + + EQ +Q++ + +G H EIED
Sbjct: 4391 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450
Query: 5764 -----KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
KP+ + + Q++ H E+ + +E SL K + + + +
Sbjct: 4451 HLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4509
Query: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
++ L E E ++ +L + + + ++L + + E T + S
Sbjct: 4510 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS---- 4565
Query: 5879 CRSPSPVANTDA-SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 5937
PS + +T +++ + +++ R Q ++ + + + F + L
Sbjct: 4566 --RPSLILDTVLFQIDEHKVFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLL 4621
Query: 5938 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5997
+Q WE + + E+ R+L +A +R +++ ++ + +E E L E P+
Sbjct: 4622 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPD 4681
Query: 5998 ---SQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
+Q+A+H+ + L + + + + L ++ AD + L L L+ L ++
Sbjct: 4682 KIKTQLAQHKE-FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKW 4738
Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
TI K+ ++ LEE L L + ALQ L WL + L P
Sbjct: 4739 DTICGKSVERQNKLEEAL---LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVH 4787
Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
+D+ L+D + K + + + L+EG ++D++ + +++ L
Sbjct: 4788 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELST 4844
Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQ 6225
+ KQ ++ ++ EE + A + EWLA+A T
Sbjct: 4845 RWETVCALSISKQTRLEAALRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDED 4899
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
++ + Q KE ++L E+++ L + G+ +L
Sbjct: 4900 ALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4933
Score = 224 bits (570), Expect = 4e-57
Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)
Query: 500 LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 551
L+K + EL +L L E S + W+ K + + Q + + +E +K
Sbjct: 2443 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2502
Query: 552 FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
FE Q Q LK ++ + EA + + E ++W+ L+ +
Sbjct: 2503 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2562
Query: 608 LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 654
LEE +N ++ A L+ WL + E MLN + +
Sbjct: 2563 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2622
Query: 655 QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 711
Q+ + AG ++ D + +K+QL + +W L ++ D+
Sbjct: 2623 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2682
Query: 712 EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 761
+Y + +LS ++ KLS L VS MN +L + Q+++ ++++ V A
Sbjct: 2683 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2742
Query: 762 --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 814
+ K +L + S Q EG K K + + ++ C S ++ S+
Sbjct: 2743 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2802
Query: 815 IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 871
L+ +++ + K++ + +++ + + S L Q H ++ +A EN L L
Sbjct: 2803 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2858
Query: 872 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 931
+GS+ + L+ + ++D +Q+ + + ++K +K+ VET + K
Sbjct: 2859 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2916
Query: 932 FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 989
+ + E++ L A EG + L + + F ++ N+ L C+ +++
Sbjct: 2917 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2975
Query: 990 PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1046
++ + +Q+ +LH + L+ ++ E R L +E +LD
Sbjct: 2976 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3032
Query: 1047 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1106
L Q S K + + + + + ++ L + L L V D+ GT V L+
Sbjct: 3033 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3087
Query: 1107 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1164
E A ST + +++ + + + F + I +Q E A G
Sbjct: 3088 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3147
Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
++ K+ ET+ +L+ L ++S + A K + + LV + ++
Sbjct: 3148 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3198
Query: 1225 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1265
E K + D Q +E +K LEE S KE + Q ++T
Sbjct: 3199 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3257
Query: 1266 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1321
E + + + + +++ + + K++DV Q + Q+ H +L + +
Sbjct: 3258 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3316
Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1379
L + ++ ++Q L RF+ E+++ ++ T ++++ S + + + +++
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3375
Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1437
++ K + + E + +E +I P +K + +Q + + + L + E
Sbjct: 3376 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3435
Query: 1438 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1494
+ +E + F E L+ W+T EK L + T +S ++ QI+Q K +I
Sbjct: 3436 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3495
Query: 1495 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1554
+ + QS + + +++KL + + E++E + + L
Sbjct: 3496 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3555
Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1607
+ F E+ ++ ++E DKL+ + + +TE +VLQE D+ +++
Sbjct: 3556 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3612
Query: 1608 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1665
A+ ++ + + + A++ +Y+DI + + + LE L +RL
Sbjct: 3613 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3672
Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
TWL++ E + S E + + +++ + L+ E + + L ++ +L
Sbjct: 3673 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3731
Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
+ + ++ + + +ER+R + I +++ + + + QQFD+ + WI
Sbjct: 3732 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3791
Query: 1786 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
+L + +I + Q + L K E+ K + L K+ + E+ ++
Sbjct: 3792 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3851
Query: 1844 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
K + + ++ Q+ R L L S + +F +++ L L + Q++ +
Sbjct: 3852 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3910
Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1957
E + + + + Q + + +D + L++ E AD L
Sbjct: 3911 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3970
Query: 1958 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2017
+++ EA + + F D+ +++L+S+E I ER + + ++++
Sbjct: 3971 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4027
Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2071
+ + ++ + LK + +++ KD++ A V +++++ W++
Sbjct: 4028 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4086
Query: 2072 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2121
L+ E + + +++L ++ ++ S ++ + T I+D ED +
Sbjct: 4087 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4137
Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2177
K ET + +++ Q++LD + G L++ K I + + +S
Sbjct: 4138 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4197
Query: 2178 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2237
W D +KLEE M + ++ D + + D ++ + + M+ ++L+ + E L
Sbjct: 4198 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4253
Query: 2238 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2294
K+F+SE + + +E L+ + + L K + D ++ LM+ KL + +E
Sbjct: 4254 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4310
Query: 2295 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2349
+ L+ Q + ++++ W T E L + E L K +Q ++
Sbjct: 4311 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370
Query: 2350 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2408
+ QS + + + N L E +L + L ++ + V + + + L +L
Sbjct: 4371 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4430
Query: 2409 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
K F +++ Q+W + S G + + +L+ + + + ++
Sbjct: 4431 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4490
Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
Q+GQ + A K ++I + I E++++ + + K L++ + F + +
Sbjct: 4491 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4550
Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
W+ + E+ N + + + HKV F E+ + RE + +L + G L +
Sbjct: 4551 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4606
Query: 2588 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2643
Q+ L LL S Q+ +++ E+ RS A + + EA + W++
Sbjct: 4607 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4666
Query: 2644 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2702
+ L D ++ +L+Q ++ G + G ++S +
Sbjct: 4667 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4726
Query: 2703 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2762
+ L L++ W I SV Q+ LE + + + L W+ V+ ++
Sbjct: 4727 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4786
Query: 2763 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2821
+ L+D+ ++ E T ++ L +REL E +D S+ +EL T++
Sbjct: 4787 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4846
Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
+ ++ K ++E ++ + VH +WL A++ L + D A + +
Sbjct: 4847 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4906
Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
+ KE + E + L++ ++ V + + +RA ++E+ + +
Sbjct: 4907 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4963
Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
+ L S +A G +A+ ++ LE A L+ WA+ T L K D+E++
Sbjct: 4964 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 5006
Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
QEI E++K+ + E F +++ V + K Y
Sbjct: 5007 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5040
Score = 210 bits (535), Expect = 4e-53
Identities = 144/429 (33%), Positives = 219/429 (51%), Gaps = 65/429 (15%)
Query: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
R+ DE++ VQK+TFTKWIN HL K + V+DL+ED++DG L++LLEVLSG LP E+
Sbjct: 57 RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 114
Query: 80 GRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELT 139
GR R H + N+ AL +L+ R++KLVNI + DI DG P + LGL+WTIIL+FQI ++
Sbjct: 115 GRM--RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 172
Query: 140 SNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE 199
V+ E+ +AK+ LL W Q GI
Sbjct: 173 -------------------VTGESEDM------------SAKERLLLWTQQATEGYAGIR 201
Query: 200 VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPE 259
++F WR G F+++IH RP+L+D+ TV +SN NLE AF +AE ++G+ RLLDPE
Sbjct: 202 CENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPE 260
Query: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
DVDV PDEKS++TYV+ +P + +G +++ + + N V + R
Sbjct: 261 DVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYLIQWIRHH 319
Query: 320 FKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHLIQPLHRD 375
M ER + L ++Y FK + + K K++ L++
Sbjct: 320 VTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEF 373
Query: 376 GKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVH 435
G++ L Q ++ +W G + + E ALR E+ ++
Sbjct: 374 GRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPEVERLEML 415
Query: 436 EETANTIQR 444
++ AN +QR
Sbjct: 416 QQIANRVQR 424
Score = 162 bits (411), Expect = 1e-38
Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)
Query: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 1038 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1095
Query: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 1096 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1155
Query: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 1156 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1200
Query: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 1201 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1251
Query: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 1252 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1311
Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 1312 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1371
Query: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 1372 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1431
Query: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 1432 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1491
Query: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
EK + S QK S KE +T L +K +
Sbjct: 1492 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1551
Query: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 1552 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1611
Query: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 1612 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1665
Query: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 1666 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1725
Query: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
W+ ++ + H + T
Sbjct: 1726 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1785
Query: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 1786 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1845
Query: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 1846 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1905
Query: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 1906 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1965
Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 1966 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2024
Query: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 2025 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2081
Query: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 2082 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2141
Query: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 2142 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2201
Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 2202 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2256
Query: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 2257 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2315
Query: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 2316 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2373
Query: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
+ S+ NL + A A T+ E SI++ ++
Sbjct: 2374 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2433
Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 2434 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2493
Query: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 2494 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2553
Query: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 2554 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2613
Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 2614 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2673
Query: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 2674 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2729
Query: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
V E DLS ++ +A S EG + KD + +
Sbjct: 2730 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2784
Query: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
SA S Q +Q+ + A D++ + Q + I +K L +K + K L S
Sbjct: 2785 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2844
Query: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
+ ++ E+ L + + S + L +T W+ Q +E ++K++L+K
Sbjct: 2845 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 2899
Query: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
++ + ++W W+ + LE+ ++ D E I KLK LQK +D ++
Sbjct: 2900 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2956
Query: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
+N + + + D + + D V L + L++ + + F E+S
Sbjct: 2957 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3016
Query: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
L E +D + SN +LQ K L +KH++ L QD+
Sbjct: 3017 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 3073
Query: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
+ +++GT + +V I L ++V LE KL + Q + S
Sbjct: 3074 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3130
Query: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
DELD+ V GR QK
Sbjct: 3131 AEFDDELDSMAPV----GRDAETLQK 3152
Score = 96.3 bits (238), Expect = 1e-18
Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)
Query: 6806 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 639 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 691
Query: 6863 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6922
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 692 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 743
Query: 6923 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 744 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 795
Query: 6983 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 7041
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 796 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 853
Query: 7042 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7099
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 854 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 906
Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7154
+T + + +I + D +SH+ + I+ EA
Sbjct: 907 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 966
Query: 7155 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 967 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 1026
Query: 7209 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7253
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 1027 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1086
Query: 7254 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7293
Q++ EDR ++ +D + V I + L K L
Sbjct: 1087 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1145
Query: 7294 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 1146 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1202
Query: 7354 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7407
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 1203 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1262
Query: 7408 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7456
+L + + + KE ++ L W + Q R L+ L
Sbjct: 1263 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1322
Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 1323 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1378
Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1379 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1423
Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
+ E L V + Q + D ++ E+
Sbjct: 1424 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1459
Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7692
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1460 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1513
Query: 7693 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7750
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1514 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1561
Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7806
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1562 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1613
Query: 7807 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7852
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1614 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1673
Query: 7853 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7905
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1674 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1733
Query: 7906 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7930
SE A K ++ S EE Q LN+Q
Sbjct: 1734 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1793
Query: 7931 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7985
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1794 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1852
Query: 7986 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 1853 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1911
Query: 8045 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8092
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 1912 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1971
Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8146
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 1972 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2029
Query: 8147 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8204
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 2030 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2089
Query: 8205 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 8260
++KL ++ L R L ++D L W SL P S+ L
Sbjct: 2090 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2139
Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 8319
+++ + E+ +S+++ ++ ++ M PS Q KD R
Sbjct: 2140 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2189
Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
+ S H +++ +L ++ ++ + + +KT E+D K +L
Sbjct: 2190 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2248
Query: 8380 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
S LEHK E SL ++ H + A V+++ L + E +K+
Sbjct: 2249 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2306
Query: 8439 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 8475
++ F + S+ +W+ +T ++ LE ++L+ +
Sbjct: 2307 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2366
Query: 8476 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 8520
+T E+Q L L AV I ++ + + E T +++E +
Sbjct: 2367 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2426
Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
+ ++ ++ ++ + LL++ L L + Q E S ++ L+ +++ +
Sbjct: 2427 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2486
Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
+ D E ++ +Q + EL ++ +V L+D +LL E D EA
Sbjct: 2487 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2536
Query: 8641 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 8685
R K +L E+ +EL +L L+ SS+ + L W EL S +
Sbjct: 2537 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2595
Query: 8686 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 8745
P S PN T R + + + P LS PG S RG + L
Sbjct: 2596 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2653
Query: 8746 RA 8747
A
Sbjct: 2654 AA 2655
Score = 54.7 bits (130), Expect = 4e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 366 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 4629 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4677
Query: 425 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 4678 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4721
Query: 479 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4781
Query: 525 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 4782 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4836
Query: 585 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 4837 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4896
Query: 639 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 4897 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4956
Query: 692 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 4957 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5016
Query: 747 QD----LEDIEQRVPVMDAQYKIITKT 769
+ +E++ ++ P +D +TKT
Sbjct: 5017 AEHQTFMEEMTRKQPDVDK----VTKT 5039
Score = 33.9 bits (76), Expect = 7.3
Identities = 90/474 (18%), Positives = 181/474 (38%), Gaps = 61/474 (12%)
Query: 8169 QGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 8228
Q +QL+++ A + +E+ LR C V+ + + +L + L+ +
Sbjct: 487 QADQLVQR-----VAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ 541
Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
+ S L SL SS+++ L+ + S + TPA P
Sbjct: 542 TLHPSLTSGL------TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS----- 590
Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG--DHSALESQI-----RQLGKA 8341
L + S + E Q K +R + S D + E +I + L
Sbjct: 591 -GLVPNFSSGV------EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 643
Query: 8342 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
+D+ + Q+ +TE S P+ ++K + + E SS+ E K+ E + +
Sbjct: 644 VDEMQVQLDRTE--WGSDLPSVESHLENHKNVHRAIEEFESSLK-----EAKISEIQMTA 696
Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8461
P + A + R E A+ L+ +++L F S + WL + EE
Sbjct: 697 P-------LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 749
Query: 8462 ELEQLQRLELSTDIQTIELQIKKLK----ELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
E E++ D I + K EL + +D ++ I S+ + + +
Sbjct: 750 E-------EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPAR 802
Query: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHG--LLLMLENIDRRKNE 8575
++ + M +W + L + +++ + F++ L L++ +RK
Sbjct: 803 LTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK-- 860
Query: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDC 8628
D + L+D ++ M+ K ELL+ + +A+L + ++ + +DC
Sbjct: 861 -YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 913
Score = 33.5 bits (75), Expect = 9.6
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 375 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4781
Query: 427 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 4782 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4840
Query: 484 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 4841 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4900
Query: 536 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 4901 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4944
Query: 592 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 4945 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4987
Query: 652 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 4988 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5038
Query: 712 EY 713
Y
Sbjct: 5039 TY 5040
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 372 bits (955), Expect = e-102
Identities = 717/4026 (17%), Positives = 1587/4026 (39%), Gaps = 438/4026 (10%)
Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 1325 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1381
Query: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1440
Query: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
T +V +Y+ G S +R +SL E ++ E +K +
Sbjct: 1441 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1498
Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1453
+K+A + P +KQ K E++ ++ L E ++T+++ K D +
Sbjct: 1499 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1552
Query: 1454 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1506
E + E + L L+ S ++ D+++ + + QE + KL I L +
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1566
++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1613 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1669
Query: 1567 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1626
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1670 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1711
Query: 1627 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1673
A++++ E + +++ +E +T +ENLL ++K+ + T +
Sbjct: 1712 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1767
Query: 1674 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1713
G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1768 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1827
Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1828 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1885
Query: 1774 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1828
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 1886 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1945
Query: 1829 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
K+ + ++ A D F+ V+ L L + Q
Sbjct: 1946 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 2002
Query: 1877 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1930
+ S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++ +
Sbjct: 2003 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2061
Query: 1931 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1988
A+ L S + + T D + G E + + + + + QD +
Sbjct: 2062 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2121
Query: 1989 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
E+L + ++E ++ ALQ + LE ++ + + + +K K+ +
Sbjct: 2122 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2181
Query: 2049 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
D + A + ++ L + + E + L + ++NL + LE +
Sbjct: 2182 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2241
Query: 2108 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2162
+ T + KD +L Y Q+ F KHL S LK+I S
Sbjct: 2242 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2287
Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2216
+ +D ++K ++S+K +E D ++ + V S +++++ + +
Sbjct: 2288 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2341
Query: 2217 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2269
+ + + + + AE+L K E K + +L+ E+ KVN+ L L +
Sbjct: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2400
Query: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2328
TP AK I V G + + +T E+F + T +++ +
Sbjct: 2401 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2442
Query: 2329 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
+ + L +KD EL ++ S + QE +++ + + T
Sbjct: 2443 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2501
Query: 2389 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2448
EAV KTQ +S E +++ + QE L+ KL +
Sbjct: 2502 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2535
Query: 2449 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
L + + T A KQ+ +T+ + ++Q + + +Q
Sbjct: 2536 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2572
Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2573 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2630
Query: 2569 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2624
+ ++L+ GQ +LS G G + QL Q +T + C A+
Sbjct: 2631 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2690
Query: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2682
+ + L+S+ + + ++L+ + + D + ++L Q + + + + ++K+
Sbjct: 2691 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2750
Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2751 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2809
Query: 2743 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2793
+ W+++ +Q HP+ + LD L+S++ + +D ++ L +
Sbjct: 2810 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2860
Query: 2794 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y + V
Sbjct: 2861 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2919
Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
W+ Q L +IK +D E G + +++++SL E+ Q+
Sbjct: 2920 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2961
Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
EL++ +L + + ++ V L V + + + Q +
Sbjct: 2962 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3019
Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
+F + K +QL + + + + + L LQ + + LK Q++ R +
Sbjct: 3020 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3079
Query: 3031 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3071
+DL + G + +E++ L Q + C E LQ +
Sbjct: 3080 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3139
Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3131
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 3140 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3199
Query: 3132 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3191
L+ GI+ + A + +E +E ++++F + L K
Sbjct: 3200 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3253
Query: 3192 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3246
E+ HE S + + QQ + + EP L+ K Q + W GQ +A
Sbjct: 3254 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3307
Query: 3247 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 3308 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3367
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
++ + P+++ V+ ++ + + L + +++ +++I GE + P I +
Sbjct: 3368 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3427
Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
QL + W +LL+ QLEG + + + + W+ ++E L E +
Sbjct: 3428 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3487
Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3475
+ + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3488 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3547
Query: 3476 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3532
IQE++ ++ + + + D WL + +KL + SV + ++ L
Sbjct: 3548 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3607
Query: 3533 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
R LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3608 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3665
Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWHEE 3647
+ R + +++ WL E E +S T+ + Q+ ++KK +
Sbjct: 3666 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3725
Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
A D + EV + E++ +R G + + RY+ + + ++++ ++ I
Sbjct: 3726 NKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3782
Query: 3706 SLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
++ + + + W T K + + + D+ + +K T+E+L +
Sbjct: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKD 3837
Query: 3763 LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3822
++ + G + + E E + ++K++ ++ + + ++ LE+ L +F
Sbjct: 3838 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3897
Query: 3823 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
+ + L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G
Sbjct: 3898 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3957
Query: 3883 LLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
LLEL + ++++K + Y + K+ +L+ + ++ ++ ++ + L +
Sbjct: 3958 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 4017
Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC------ 3994
+ RL P + ++ +E I +Q++ +K + ++ + L+ +G+ +I +
Sbjct: 4018 IVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4076
Query: 3995 --ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
A +Q KL Q N+H ++ + + A++ + H+S T++
Sbjct: 4077 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIK 4129
Query: 4047 QCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLS 4100
Q ++ ++ P ++PS + AE I++ LQE+ ++L L + C +
Sbjct: 4130 DTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPD 4187
Query: 4101 NASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4156
VK + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 4188 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4247
Query: 4157 KRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHL 4214
++LE + + ++K F + +Q + + + L KK EES +H + L
Sbjct: 4248 SPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 4305
Query: 4215 NDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4271
+ W L + N + E L + ++ + +L +
Sbjct: 4306 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 4365
Query: 4272 AVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE 4329
A+ +E K L + + +E + +IE ++ ++ + L QRW +
Sbjct: 4366 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4425
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ +++ Q L + ++L +W + + ++ + P+ A+ L H+
Sbjct: 4426 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4485
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+C+ EAK+ KSL++ +++A + I + +++ + + + +R+ L
Sbjct: 4486 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4545
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4509
+AL+ +F ++ + + Q E+ + L+ D V Q+ K + +++ +
Sbjct: 4546 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4605
Query: 4510 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4569
+ L G L +Q+ + L +QS ++ V+Q+ R + L+ K F E
Sbjct: 4606 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4665
Query: 4570 DFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTI 4629
+ K WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4666 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725
Query: 4630 LPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L
Sbjct: 4726 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4785
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTG 4744
+E Q V D ++ ++L D +A E+ +V L + EG R
Sbjct: 4786 RVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4843
Query: 4745 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
W +M L T + + + + + LE +E + L L + EQ+
Sbjct: 4844 S-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLR 4900
Query: 4805 NEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4859
LP +E + + L++ L + T + + P + +H I
Sbjct: 4901 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4960
Query: 4860 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4919
+ + + + + S + I Q + L WL+ + L+ D + +
Sbjct: 4961 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEV 5015
Query: 4920 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
I +EI +++ E Q+ + M + +K TK + +AD + + LD
Sbjct: 5016 IPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG 5074
Query: 4980 ALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLA 5019
R ++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 5075 RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFA 5134
Query: 5020 GNGLDV 5025
D+
Sbjct: 5135 NFDFDI 5140
Score = 340 bits (873), Expect = 3e-92
Identities = 720/4013 (17%), Positives = 1591/4013 (39%), Gaps = 492/4013 (12%)
Query: 442 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 1152 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1209
Query: 502 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
K++ + L +L AE+ +K + K E+V + ++N +S + E
Sbjct: 1210 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1266
Query: 551 KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
+ F E ++ ++ K E + D E+A+ +++ +W+N+ V++
Sbjct: 1267 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 1319
Query: 603 SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
+ LE + + Y +T L W++ E NQ EN+K + N +
Sbjct: 1320 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1379
Query: 657 HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
M + + E S +K L +++ + + VK+ D +
Sbjct: 1380 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1436
Query: 710 KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
+E+ D +A T +++ ++ + ++K L ++ + +E+ + K + K
Sbjct: 1437 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1492
Query: 770 AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
I+K + ++ GK F+ E+++ KE S L Q L
Sbjct: 1493 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1552
Query: 819 ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
ELEKQ+ + +S + +E+Q+S K + + + Q+ K+ L
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
Query: 871 ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
+I G+ ++K+ + L+ D + +A++ ++ +K+ G+
Sbjct: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1671
Query: 919 -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
K +E +L K E+S+ EL+KV+ A +E E+ ++L T
Sbjct: 1672 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1731
Query: 965 EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
+ + LD +L D+ ++ + +Q +++ H Q D + E +
Sbjct: 1732 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1783
Query: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
LL +D + + + +E + ++ K EKII +H+ V + + L EK+
Sbjct: 1784 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1835
Query: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
Q + EE K ++ +++ L E + T+ L E+ +K+ DYT
Sbjct: 1836 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 1887
Query: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
EF W+ +E +L+ ++ A D ++KR + ++ +G+ S +VL
Sbjct: 1888 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1947
Query: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
S + + + KL + +L S+ + +N D V + +++
Sbjct: 1948 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 2007
Query: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
L++G + + A K L +E + + L ++TK + + Q + + ++
Sbjct: 2008 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2066
Query: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
L D L ++ TLD L +S + ++Q+TL + + + ++ +
Sbjct: 2067 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2126
Query: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
+ SS + L+ ++L+ +S + ++ + R SI E VK+ E P
Sbjct: 2127 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 2184
Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
LQ + K + + + +E + ME +KTK + F + E L ++ K + L
Sbjct: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244
Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
++ + ++ + E + L + + + A + K +
Sbjct: 2245 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 2304
Query: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
+ +E+ + + + + Q F+ ++ ++ + E
Sbjct: 2305 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 2364
Query: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
ED + K E KV + LC + ++++ A +A S V+N +
Sbjct: 2365 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2424
Query: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
S ++ + YED+ K++ L L+ Q+ ++E S+ + WL+
Sbjct: 2425 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2484
Query: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
+ A+ + D A + +VE L+ V KL +L E
Sbjct: 2485 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2544
Query: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLF 1784
K M L ++D +W++L Q+ R L+ QF + W+ +L
Sbjct: 2545 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2601
Query: 1785 LSELQTTS-----------EISIMDHQVALTRHKDH------AAEVESKKGELQSLQGHL 1827
+S L S ++ I+ + A TR + + S+ GE SL+G +
Sbjct: 2602 VSVLGPLSIDPNMLNTQRQQVQILLQEFA-TRKPQYEQLTAAGQGILSRPGEDPSLRG-I 2659
Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA---------------- 1871
K + L G+ D ++A + Q L L+
Sbjct: 2660 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2719
Query: 1872 --------EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAA 1923
+ L++ + ++Q ++ ++ ++ ++ S L++++ A + ++ LE
Sbjct: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGIL 2778
Query: 1924 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD-------AL 1976
S + KA+ H+ + S A++ Q Q L TK+ E + L
Sbjct: 2779 KSFKDVEQKAENHV-----QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2833
Query: 1977 AVLKKAFQDQKE--ELLKSIEDIEERTDKE------RLKEPTRQALQQRLRVFNQLEDEL 2028
VL+ +D K+ + L + + E+T E + + + ALQ +L D
Sbjct: 2834 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2893
Query: 2029 N----SHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE---VTWDDTK--------RL 2073
N E++L +KA + ++ P +D+ N LE D + +
Sbjct: 2894 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2953
Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSK-----VLENASSVIVTRTTIKDQ--------ED 2120
+ + Q G+++L+ N +V + V + S+I + +Q E+
Sbjct: 2954 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3013
Query: 2121 LKWAFSKHE----TAKNKMNYKQKDLDNFTSKGKHLLS---------------------E 2155
+ F + + +K ++ ++ LD S G S +
Sbjct: 3014 MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3073
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
L K + D + +D + T D L V E + + L + L T+ + G N
Sbjct: 3074 LAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQN 3132
Query: 2216 CVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2268
+ +M + D+ L R E L++ + +K +LE L + ++ + K +
Sbjct: 3133 TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM 3192
Query: 2269 ----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
ET PDL I+ DL + ++ + A+ A+ QVE I + +++K++
Sbjct: 3193 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTIKRLEEFYSKLK 3245
Query: 2325 E---SLMNCAQNETCEA------------LKKVKDIQKE----LQSQQSNISSTQENLNS 2365
E L ++E + L K QKE LQ +Q +++ + L
Sbjct: 3246 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQ 3305
Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFL 2423
K S + L + + + + +++ ++ A LQE+L F ++++ W +
Sbjct: 3306 SAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3363
Query: 2424 GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2483
+ + + KV++A++ + + + + D +S ++ + +EG+ +
Sbjct: 3364 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Query: 2484 SIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTEN 2542
I +Q++ + ++A L + + L+ + F + LN W+ +E+R N E
Sbjct: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
Query: 2543 LGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
+G + E+ ++++ L + ++ +SL LS R E Q
Sbjct: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR------EDKDMVQSK 3537
Query: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
SQ+ + + + + Q AL + E + W+ + D+L+
Sbjct: 3538 LDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDY 3595
Query: 2656 SKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLK 2711
S + L K+ S++ +DILL K ++ A+ G + L+ + + +IQ +LE +K
Sbjct: 3596 STEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3651
Query: 2712 EVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI----------EHPLQ 2761
+ DI S TLE + +L W++ V+ ++ E Q
Sbjct: 3652 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3711
Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESFKDTAQEELKTQ 2820
Q KE + +++L + + AL L+ ++RE EK E +
Sbjct: 3712 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED---------NER 3762
Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
+ + +K+ +++ + + A W+ +++L D+ + T +L
Sbjct: 3763 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3822
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
K + EI + ++ + SG ++M + + K+ D V +
Sbjct: 3823 QVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871
Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD-EEIVECW 2999
+ + S+ L + V Q + E+ L ++ L + E + +
Sbjct: 3872 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3931
Query: 3000 HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY---NCLCLQASK 3056
+ +++ + + + +P + + +L S G+ + ++Y + L Q +
Sbjct: 3932 EEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLYSQIKE 3985
Query: 3057 GCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3116
+ + L + ++ F + + + + + +S ++KI+E +SE++N
Sbjct: 3986 DVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4044
Query: 3117 GQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDWKNFHSNLHQKE 3165
+ + E L ++ + AK +Q K+ W+N H+ + ++E
Sbjct: 4045 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
Query: 3166 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHC 3225
+ L ++ + F + + T+ + + + D +++Q+ +++ EEI
Sbjct: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDG 4164
Query: 3226 YEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3283
+ +L+ + +L G+ + + +L+S + +L+ K+++ +L+ +
Sbjct: 4165 LQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAV 4224
Query: 3284 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
Q+ G++ + DW+ A L S +D + + +L+ S +++I+M+ + +
Sbjct: 4225 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4284
Query: 3344 GESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E +L+ + E T+Q L +K +W SL I + +LEGAL +Q + +
Sbjct: 4285 AELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4344
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYV- 3461
W+ E L+E + + + L K +L +VL++ S +E + G + E
Sbjct: 4345 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4404
Query: 3462 -----TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD 3516
Q +L+ L +R++ + E+ ++ + + +R + + +++ + WL + L
Sbjct: 4405 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4464
Query: 3517 QYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALE 3573
L G T + L E+ + S++ + ++ AE D+ +
Sbjct: 4465 ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN 4524
Query: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
+L++ W++ + +L+E +T+ +N Q WL AE+ ++ +R T
Sbjct: 4525 NLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT 4584
Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLL 3691
Q+ + K + EV ++R+++ E+ + S + + + SR++ ++
Sbjct: 4585 VLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQ 4644
Query: 3692 QVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLK 3748
+++E+ + L++ + ++ + S +W + K+ + +A DK+ T +L
Sbjct: 4645 RLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKT-----QLA 4699
Query: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV---- 3804
+ K + HS+ + G R++K + L+ + D + +L++ T+
Sbjct: 4700 QHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSELRDKWDTICGKS 4756
Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
+ LE+ L + +F+D +AL W+ + L + ++ + +K+ Q+
Sbjct: 4757 VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQK 4816
Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
+ SV++++ L+E +D + +K ++ +L + ++ +C++ LEA ++
Sbjct: 4817 ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4876
Query: 3923 DHEDYNSELQEVEKWLLQMSGRL----VAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
E+++S + + +WL + L V PD + +L T+ Q HK M+++
Sbjct: 4877 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPD--DEDALRTLIDQ---HKEFMKKLEEKRA 4931
Query: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
LN GDT++ C +K + + + + + A++ Q L L
Sbjct: 4932 ELNKATTMGDTVLAICHPDSITTIKHWITI----IRARFEEVLAWAKQHQQRLASALAGL 4987
Query: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4091
+++Q+ L+ AWL + L + + ++++ +AL + +T+++
Sbjct: 4988 IAKQELLEALLAWLQWAETTLTDKDKEVIP-----QEIEEVKALIAEHQTFME 5035
Score = 320 bits (819), Expect = 5e-86
Identities = 790/4278 (18%), Positives = 1616/4278 (37%), Gaps = 541/4278 (12%)
Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1337
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 1045 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1104
Query: 1338 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1387
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 1105 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1161
Query: 1388 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1447
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 1162 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1220
Query: 1448 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1507
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 1221 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1276
Query: 1508 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1540
Q S F T E +I +L + G+ L+ +
Sbjct: 1277 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1336
Query: 1541 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 1337 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1389
Query: 1598 LCQAL-ESLSSAITAFS-----------ASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1645
CQ E S+ + + + + V R A + Q++ D+ +
Sbjct: 1390 ECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL----RT 1445
Query: 1646 RQTALENLLAHW--------QRLEKELSSFLTWLERGEAKASSPEMDIS-ADRVKVEGEL 1696
R TAL L+ + +RLE+E S + KA + +S + + E
Sbjct: 1446 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1505
Query: 1697 QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKR 1756
+ +S +K QL E+L ++ +L L + ++ D +
Sbjct: 1506 AGKPPFSKQKISSEEISTKKEQLSEALQTI---------QLFLAKHGDKMTD------EE 1550
Query: 1757 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESK 1816
N L+ V Q+ LL S S+ L E QT+ ++ + + ++ R +++ +++
Sbjct: 1551 RNELEKQVKTLQESYNLLFSESL---KQLQESQTSGDVKV-EEKIVAERQQEYKEKLQGI 1606
Query: 1817 KGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
L + L +G E + G E +++ Q L + +Q
Sbjct: 1607 CDLLTQTENRL-----IGHQEAFMIGDGTVE------------LKKYQSKQEELQKDMQG 1649
Query: 1877 HA-SLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKAL----ESAAVSLDGIL 1930
A +L+ +++ + E +++ + LIE+ LN+A + L E + LD ++
Sbjct: 1650 SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1709
Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL------------------------ 1966
+ A ++ T A QL +I+NLL
Sbjct: 1710 TTA--------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1761
Query: 1967 GTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2023
GT E D K A ++ E LL++ D + T +E L + ++ Q ++ +Q
Sbjct: 1762 GTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1817
Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT-------KRLIHE 2076
+ + + + L+ + + ++ ++ ++ + + L+V ++ +L H
Sbjct: 1818 HQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTHS 1874
Query: 2077 NQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
Q + E+++ + LEN A + T +K Q+ H+
Sbjct: 1875 LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG-- 1932
Query: 2133 NKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRL 2192
DL T G +L K D V T +V KL+ DR
Sbjct: 1933 --------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHR-----EVQRKLDHATDRF 1979
Query: 2193 RVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISNLDNHL------------RA 2233
R S + D++ E S + + + HL R
Sbjct: 1980 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2039
Query: 2234 EELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEIT 2292
E K + ++ ++ + +E+L L + +L D+Q D++ + E +
Sbjct: 2040 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2099
Query: 2293 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ---NETC--EALKKVKDIQK 2347
L+ +S V+ ++++ W VE SL Q N T + + K +++
Sbjct: 2100 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2159
Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
++ +QS+I++ E + + SL M L + S +T A ++E
Sbjct: 2160 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2219
Query: 2408 EK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
K E++ E + FL K A D G V E + +Q + + L+ +
Sbjct: 2220 TKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY-MQESTSEFLEHKKHLEVL 2277
Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
+ + +H + + E+ +++F+ + K+A+ C +L +F+ +
Sbjct: 2278 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337
Query: 2527 LNLWIHEMEER-------FNTENLGESKQHIPE-------KKNEVHKVE---MFLGELLA 2569
L WI E ++ F E+LG+S + + K E+ KV + L L++
Sbjct: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
Query: 2570 A----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-----------HQNLLRMTKE 2614
A +++ + G +L+ EG E ++ LTS +++L + K+
Sbjct: 2398 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2457
Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
K+ L + + +E +M W++ + + T DT + Q+
Sbjct: 2458 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQN---KS 2514
Query: 2675 GEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLETLKEVWADIMSSSVHAQSTL 2728
E E+K N+ + + + L +E + L + W ++ ++ Q L
Sbjct: 2515 FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL 2574
Query: 2729 ESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDH 2786
E + + + QL+QW+ + + PL P + +Q +L E
Sbjct: 2575 EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN--TQRQQVQILLQEFATR 2632
Query: 2787 TRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDIMT-VAKEKMRKVEEIVKDH 2842
+L A + + + ED S + +E+L TQ D +T ++ +++ +
Sbjct: 2633 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2692
Query: 2843 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELI--DSREIGASRL 2897
Y + +D L +L +S A ++L K+K+ I + ++I ++
Sbjct: 2693 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQ- 2751
Query: 2898 SRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2956
+ E L+ VK+ E + E+ + L K ++D + ++ +++L S A S Q
Sbjct: 2752 ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2804
Query: 2957 EFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLEGKNTDEEIVECWHKGQEIL 3006
+Q F A L T ++ L +LE D + Q +
Sbjct: 2805 --------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2856
Query: 3007 DALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
AE LK+Q +E L+T K+ + +E L+
Sbjct: 2857 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV-----------KERENKLK 2905
Query: 3067 QRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNISEVST--SLQK-IQEFLSES 3114
+ KA + +Q W+ + + C D + + ++ SLQK + +
Sbjct: 2906 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2965
Query: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
E + N +LS E+ ++T E IQ KV E LH K+ LEN+ +
Sbjct: 2966 ELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-------LHSKKFCLENMTQK 3017
Query: 3175 MKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNR 3232
K+F EVS E + E++ +H+S L + LQ+ + + + Q++
Sbjct: 3018 FKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3074
Query: 3233 LKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3289
K AQ L + SK +V ++ ++ LS EK S L+ + F I
Sbjct: 3075 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3134
Query: 3290 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKLEALLSVKQEKEIQMKMIVT 3342
+E+ + LDS D L + KLEAL++ KM++
Sbjct: 3135 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3194
Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E TSP+ + I++ L+++ LL + Q+EG + + + +++FS
Sbjct: 3195 TEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3248
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSYSSLLETIEVKGAGM----- 3456
+ E + E L K+ EE+ + + G G+
Sbjct: 3249 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3308
Query: 3457 --TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK 3514
T + +L D+ R++ + ++ + + ++ + +Q L++ W+ +E
Sbjct: 3309 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
Query: 3515 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3574
+ + + +++ + LQ + ++ + + E + + P + + L+
Sbjct: 3369 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3428
Query: 3575 LR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNR 3631
L W+A ++ Q + + + + ++EWL T E+++ +
Sbjct: 3429 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3488
Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------DESHVNSRMG------CQA 3679
+ E Q+ Q K +++ + + + + Q + D+ V S++ +
Sbjct: 3489 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3548
Query: 3680 TQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
+ + LL Q L K F E+E++ + +W H ++ +
Sbjct: 3549 QEKSHSRSELLQQALCNAKIFGEDEVELM-----------NWLNEVHDKLSKLS--VQDY 3595
Query: 3739 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3798
T + K+ L VL +D+ + A G +K E ++ ++ + K
Sbjct: 3596 STEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3655
Query: 3799 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3858
++T TLE+ L LA+ + L W+ + + L E ++ E +
Sbjct: 3656 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3715
Query: 3859 YKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKIDQLQSDYQDLCSIGKEHVF 3915
K L++ +++ + S+ E ALLELV L+ + + Y+ + + V
Sbjct: 3716 PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3775
Query: 3916 SLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAG 3975
++A + + ++ W+ + +L++ + +T + QL K EI
Sbjct: 3776 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3834
Query: 3976 FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL 4035
+D +++L G ++ C++ + +K+ + L+ +Y IC Y LE
Sbjct: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----NYDTICQINSERYLQLERAQ 3890
Query: 4036 QKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS 4095
+T ++ WL+ Q + P P L + + R QE+ R +L+
Sbjct: 3891 SLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EYETLRQQQEEHRQLRELIAE 3943
Query: 4096 MCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--- 4149
+ KT + ++ + +I++K V A L + +IK + + L +A
Sbjct: 3944 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YSQIKEDVKKRAVALDEAISQ 4000
Query: 4150 --------DQQLQNMKRRHSEL--------ELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
DQ L++++R L E+ + +S+ K+ ++ Q T+
Sbjct: 4001 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 4060
Query: 4194 EKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCLQREE---DLQRTRDYHDCM 4246
++ ++ + + K + DQ + + + L +RE D+ + C
Sbjct: 4061 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 4120
Query: 4247 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ------ 4300
++ + K T ++ D E + +K+ A + + I+ L+++
Sbjct: 4121 HMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4176
Query: 4301 -KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4359
++I DK +VK+ L W L K +I ++ Q Q + +W
Sbjct: 4177 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4236
Query: 4360 AEEQQPNIA----------------EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4403
+ +A E LKQ Q + M+ L +EL LLK
Sbjct: 4237 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL-----LLKK 4291
Query: 4404 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4463
+ +++D+ +Q L + + + L + + R+ L AL QF A+
Sbjct: 4292 VTEESDK----------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4341
Query: 4464 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE 4523
+ + + E + ++ + P + ++ Q + +Q+ V + G +L++
Sbjct: 4342 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4401
Query: 4524 VTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI 4583
+E S + KL+ L + +VL+K R Q+L+ L K F + + WL +
Sbjct: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
Query: 4584 VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSE 4643
L QL + + E +L + GQ +L + + + +
Sbjct: 4462 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4521
Query: 4644 KLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD 4703
+N L ++ + ++ K++EA+ E+ + ++ L++ E Q L ++ P+
Sbjct: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE-QTLNVASRPS- 4579
Query: 4704 LAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ----PDKMLHLVTLY 4759
L ++ L D + +EV E + EL++ + Q + ++ + + +
Sbjct: 4580 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
Query: 4760 HRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 4811
++ ++ +R L+D A Q HE K+ + LE KS+ E N+ +T A
Sbjct: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
Query: 4812 EEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK 4866
+ K L HS+ + +G LK T +D K + + +
Sbjct: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---------KLDDMLSELRDKWD 4750
Query: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG--PVYLDLNLQDIQEEI 4924
+ E + E ++ S F + +DWL RV+ +L+ PV+ D++L + I
Sbjct: 4751 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL--VMNLI 4808
Query: 4925 RKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4984
+ Q+E+ + AL +E +++ S+ ++ + ELS + ++
Sbjct: 4809 DNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKVQMQELSTRWETVCALSISK 4867
Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL-KSHMEFFSTED 5043
Q L Q + ++ V A +WL +A++ L+ G D E A L H EF +
Sbjct: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927
Query: 5044 QFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQKVASLELRSQRMSRDSG-- 5090
+ + L + ++ T+ + P + E+ +A + QR++
Sbjct: 4928 EKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL 4987
Query: 5091 -AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEK 5141
A+ +LL+ A QW + K +E + + + + + ++E F T + ++
Sbjct: 4988 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5047
Query: 5142 LSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGNDASKATLSRSMTTVWQRWT 5193
+K + +S I L++ AS L +G+ T + + + +W
Sbjct: 5048 TKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQ 5107
Query: 5194 RLRAVAQDQEKILEDAVD 5211
++ +A ++ + L DA+D
Sbjct: 5108 QVWLLALERRRKLNDALD 5125
Score = 318 bits (815), Expect = 1e-85
Identities = 900/4830 (18%), Positives = 1875/4830 (38%), Gaps = 684/4830 (14%)
Query: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
V+ W+D M+ L+ +E ++L + L K ++ + + S L+ ++ MT
Sbjct: 648 VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706
Query: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
L+L ++ +R + AK T + L LH R +WL +++E+
Sbjct: 707 ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 761
Query: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
Y E + + H +R+L + + + Q + +L P+ +
Sbjct: 762 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 818
Query: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
RA + W Q + + E F ++ ++L+ ++ +
Sbjct: 819 YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 870
Query: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
+ R S+ E + + + EE+ Y+ + + +A+ I+ NS + +
Sbjct: 871 KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 930
Query: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
+ Y+ + + + + + + + ++ S +E+ + S +K +
Sbjct: 931 PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 990
Query: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
+A +I++ + + TL + +K + H L+ R ++K + GE
Sbjct: 991 LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 1045
Query: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
++ L+ D +E +E + LEK +++ K++ YQE+L
Sbjct: 1046 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 1092
Query: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
E + E +S+ ++++ + + E ++ +R + E++ + + L
Sbjct: 1093 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1152
Query: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
K ++++L+ D + + +E FS A SEL V + + Q MS + D
Sbjct: 1153 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 1209
Query: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
L+T +L Q A + + EE A D+ NN++ TL Q + K +
Sbjct: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 1266
Query: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
Q HA L+ AI + Y+ + + H + D L + W + VQ D
Sbjct: 1267 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 1321
Query: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
L E I K +K++R ++ V+TT + IQ+ + +T
Sbjct: 1322 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1366
Query: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
+ +L Q + L EI+ +S++ + A+Q +K EL+ + MV +
Sbjct: 1367 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1421
Query: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
K + Q+S + II++ L + + + L Q++ S + E+ L+
Sbjct: 1422 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1476
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
+ H V K +W S+ T E K + Q K + E++
Sbjct: 1477 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1523
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
+K+++ E L L K ++ +LE +K T E N++ F E +
Sbjct: 1524 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1573
Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
+ +E Q + +++ + Q IC L + LI + M G
Sbjct: 1574 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1630
Query: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
E + Q +++ L K + Q L V + T + + +
Sbjct: 1631 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1672
Query: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
+E L+ +++ C+ Q +LK Q++ +EL K VT E EK
Sbjct: 1673 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1722
Query: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
+ +L+E ++ +++L K S R K ++ + HF+E + D+
Sbjct: 1723 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1782
Query: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
L + D+ N + + A+++ I+ Q ++ + L++ GQ + P
Sbjct: 1783 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1842
Query: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
E L + + L + +A ++ K + +QE + E+ ++ + Q
Sbjct: 1843 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1898
Query: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
L LEA ++ + T L E+ +S + R I + EA +++ G
Sbjct: 1899 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1958
Query: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
T + K+ H + L + + L+D YQ +E L L++ +
Sbjct: 1959 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2018
Query: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
SK E + + K L+ +L G + + LK+ L D L P A
Sbjct: 2019 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 2077
Query: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
+ + G + L+ ++ E + + + +S+ Q + LDW+ V++ L
Sbjct: 2078 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2137
Query: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
+ LN +Q+ I K + ++++ +NA++ K K+ ++ L+ + +L
Sbjct: 2138 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2197
Query: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
S + + A + E+ ++ + + + + +LE Q L ++ G DV
Sbjct: 2198 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 2255
Query: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
L +M+ ++E H +LE LHSL+ + P+ K + +K +L + + M
Sbjct: 2256 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2313
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
+ + + C Q +Q + + + +T KK+ F S E +KL E
Sbjct: 2314 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2373
Query: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
+L +S V + + I A++ + L E T + + ++
Sbjct: 2374 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2433
Query: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
+T++ + T + +D +L+D + E +K++KA E M+ LQ
Sbjct: 2434 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2493
Query: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
+ P + +A K T +E + +F EL+Q + + L+ + +L++ P E P
Sbjct: 2494 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2547
Query: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
Q +T + + + + + +++ + +T +K W+ E + LG
Sbjct: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607
Query: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
+I+ ++ Q +++QILL E + E++ + G+ + + SL Q
Sbjct: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2663
Query: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
LA V + Q+ D+ ++Q+ S Q Q L + L+ L+ L K + +
Sbjct: 2664 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2719
Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
T + ++L+ E+ ++ L + L L++++ + +
Sbjct: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2779
Query: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
+ ++AEN + L A + ++ +M W++ K N + + +
Sbjct: 2780 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2833
Query: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
+ ++L+++ K+ L A + + + E + + G E L+ + N
Sbjct: 2834 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 2889
Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
K +K+ E +LK+ +LE+A L KEQ+ + L ++ + +
Sbjct: 2890 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 2932
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
+ ++ C E+ +A L LQ+E QH + + +++ +
Sbjct: 2933 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 2983
Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
E E K L Q ++ ++ K N+ QE+ + R + A++ +
Sbjct: 2984 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3043
Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
+ S K LTM L + LA+ GT D+ ++
Sbjct: 3044 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3103
Query: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
H ++ +C L + + + T E+ S A S +PV ++ +
Sbjct: 3104 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3163
Query: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
A+ + L A D A + E P L L L + L +
Sbjct: 3164 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 3222
Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
++ + ++R +++ L+ S I L+ +E E + P E++ Q M
Sbjct: 3223 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 3277
Query: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
++ ++EI LQ L + L+ + ++ + L+ L + R T+ K
Sbjct: 3278 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 3334
Query: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
+ + L+E L L R + AL+ L SW++ T+ + P E ++A
Sbjct: 3335 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3384
Query: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
Q L+D + VE+ KV L +LS+ + L KA
Sbjct: 3385 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3444
Query: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
T++ R+L+G + Q+ H+ + LN T EK + + TQ+ ++E
Sbjct: 3445 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3494
Query: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
+AQ + + K L Q ++ +SL + ++SR ++ ++Q E
Sbjct: 3495 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3549
Query: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
+ + ++L Q L K ED++ M W +H Q++ST+ Q + L
Sbjct: 3550 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3607
Query: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
QE +L + N LL+G+ L K + + L+ + +++++ S +
Sbjct: 3608 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
Query: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
Q++ L ++L+ TWLD VE L + L EE + L K+ K
Sbjct: 3667 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3726
Query: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
+D + N S A E G + V ED R L+ + Q+ ++
Sbjct: 3727 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3780
Query: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
+ + + F+Q ++ I + E L +E
Sbjct: 3781 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3814
Query: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
+ +LQV++ E+ + +D+ D+L+ + ++ ++K + ++ L++
Sbjct: 3815 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3874
Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
+ + E+ E Q L+++ E ++ L LTET + IIS
Sbjct: 3875 ICQINSERYL--------QLERAQSLVNQFWETYEELWPW--LTET--QSIIS------- 3915
Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
+L A A LEY ET QQE RQL L+ E
Sbjct: 3916 ----QLPAPA-------------LEY--ETL----RQQQEEHRQLRE---------LIAE 3943
Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
++ + +N+ P+L + L G+ I ++ +Q+ E
Sbjct: 3944 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 3985
Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
+ K L+ + T++ + ++ L+ +RL +Q ++ E+E +++ ++
Sbjct: 3986 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 4040
Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
S +++ L ++ G +++ K + ++ +L ++ W ++ T +
Sbjct: 4041 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4100
Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
+ KL L + +L + MS I +++ D I + + + +
Sbjct: 4101 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4157
Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
+ +I+ Q +D V + + S+ + + DK + + +N +W L ++I
Sbjct: 4158 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4213
Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
LE +++ +Y++ +Q + W + +L IG D +V+ +++ + +
Sbjct: 4214 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4273
Query: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
++ E+E++ L++ E+ V L EL W +L+ + + L+ L
Sbjct: 4274 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4333
Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
+ A D++ ++L LS + + G +A+++++ LQ+D+ + +++
Sbjct: 4334 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4393
Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
N L++ L N L+ +N RW N+LE+ ++ Q L+ + K + +
Sbjct: 4394 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4450
Query: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
Q D LL + + A +++ ++ C T K L + G+Q
Sbjct: 4451 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4506
Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
+ + SA + I D +L + ++E L +++T L+ + F SL+ W+
Sbjct: 4507 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4566
Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
+AE+ L S L T+ +++E K + +S + L++ G L +++
Sbjct: 4567 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4625
Query: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
++NL W + + ER L + + F E ME+L ++E+ L +
Sbjct: 4626 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4685
Query: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
EI+ + + Q H+ FQ + ++ + + G+ L E+ + DD + + L+ L
Sbjct: 4686 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4745
Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
++W + ++ +R+ ++ + ++ + + L WL V ++ V +
Sbjct: 4746 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4804
Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
L D K F ++ G +V+A K+ L+ + ++ ++ E+ +W++
Sbjct: 4805 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4860
Query: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
++ +L L+ E+ + LE L ++ L LPD + L + K
Sbjct: 4861 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4920
Query: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
E + +L + + + DT+ A D I+ + + +++ ++EE+ +Q++
Sbjct: 4921 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4980
Query: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
L E + L WL E+ ++ +I + IE++K + + EE+
Sbjct: 4981 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5040
Query: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
Q + ++ + +R A SH ++IE K +VN
Sbjct: 5041 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5100
Query: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
+WQ + L R +KL + L +++L
Sbjct: 5101 LLVSKWQQVWLLALERRRKLNDALDRLEEL 5130
Score = 298 bits (763), Expect = 2e-79
Identities = 728/4019 (18%), Positives = 1555/4019 (38%), Gaps = 470/4019 (11%)
Query: 4948 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 1148 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1207
Query: 4999 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 5043
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 1208 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1267
Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5097
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 1268 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1327
Query: 5098 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5155
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 1328 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1384
Query: 5156 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5213
K+ ++ A Q T D T++ R+M Q+ + R + + I+++ +D
Sbjct: 1385 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1444
Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
T + V T+ I D L E+ S E + H EL++ S +
Sbjct: 1445 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1497
Query: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5327
+TL + P ++ +EI+ +++ + + K K+ +E + E
Sbjct: 1498 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1557
Query: 5328 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5387
V+T S E+ + L D ++EE + + + +E KEK G
Sbjct: 1558 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1605
Query: 5388 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5430
+ +L + + + + ++LK Q+++++ Q A T L
Sbjct: 1606 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1665
Query: 5431 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
+KL+++ + L + K K + + ++A+ +K L + + + E AAV++
Sbjct: 1666 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1725
Query: 5486 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5539
E ++ L + K +E H+Q I Q + S + E +E+ +
Sbjct: 1726 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1784
Query: 5540 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5596
L+ +V GT N Q ++ H+ ++ + + + + + EK S
Sbjct: 1785 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1841
Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
EK+ + + EL E + +++ ++++KF+A+ + + L+Q++ L
Sbjct: 1842 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1901
Query: 5657 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5705
+ E G LK Q S + ++S L+ + ++ +S + V +
Sbjct: 1902 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1961
Query: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5761
R + A+ + +CN++ + V +Y+ YE L
Sbjct: 1962 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 2010
Query: 5762 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5819
+ +Q +A S+H E +A K Q Q+ + ++ + ++ + V
Sbjct: 2011 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2058
Query: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5867
+++ AE D G LLP + + GR L V E S ++
Sbjct: 2059 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2118
Query: 5868 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5919
G N E S + P ++++I Q ++ + +A ++
Sbjct: 2119 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2176
Query: 5920 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5979
E +P S AK+ DL + + E + E + + +++ + + T +
Sbjct: 2177 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2236
Query: 5980 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 6039
E L+E PG+ Q E L + + E+ SL +E+ S +D A
Sbjct: 2237 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2295
Query: 6040 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6089
L + L+ + M TI+ K Q+L + L ++E ++ + +
Sbjct: 2296 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2355
Query: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
A++L L TK + E + + N++ + A++ +V +
Sbjct: 2356 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2413
Query: 6150 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6206
+L G+ + E A K L +K + ++ D L ++ E S +
Sbjct: 2414 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2473
Query: 6207 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6255
+S + +WL + T T+ +Q+ ++Q K E EL + + ++ + +
Sbjct: 2474 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2533
Query: 6256 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6299
E+L E + D E P D QEL + E+SS
Sbjct: 2534 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2587
Query: 6300 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6337
E+ +++ +++L+ +VL +++Q Q+L Y + G+
Sbjct: 2588 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2647
Query: 6338 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6394
G+ P+ + V L + Q ++ ++ Q Q+I + + + S L
Sbjct: 2648 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2706
Query: 6395 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6454
D++ +L + A+ T NQ++ + + +K + +QA E+ V
Sbjct: 2707 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2762
Query: 6455 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
E+ L L R +L S V Q+ + LQ + + + ++ +K
Sbjct: 2763 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2820
Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6558
P++ +++ ++ K+F + +K E ++
Sbjct: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
Query: 6559 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6617
+L+ ++ +D + R + L ++L +Y+ ++ L ++ Q + + +
Sbjct: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
Query: 6618 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6673
++ E I +L KE Q +L T + + KE T + L+ + V
Sbjct: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3000
Query: 6674 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6730
++ H + LE + + + E +E RQL+ + + S+G + L T
Sbjct: 3001 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3056
Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6786
+ Q + SL + ++ + L++ S SD+ Q+ + + + + ++ ++
Sbjct: 3057 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3116
Query: 6787 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6846
LET L+ +Q+ ++ D L+ V ++ E ++ F
Sbjct: 3117 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3172
Query: 6847 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
K+++A + + T +L ++ D ++ +L + Q LL A +E++
Sbjct: 3173 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3232
Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6960
+ +L + S++ + L++ + +E + + I++ L +K F+ + +
Sbjct: 3233 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3289
Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
KQ V+++ Q ++Q +++ ++ + L +N W+ L V ++ L+
Sbjct: 3290 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3344
Query: 7021 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
L +++ ++ L +W +T+E Q+ + V+ +++ + L+ L+ ++ VE
Sbjct: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3404
Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
I++ G + + ++ L L W L + L+ +
Sbjct: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3464
Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7199
+ +N +L L + ++ Q+ + L+DD+ + L + SI Q LK
Sbjct: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3523
Query: 7200 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7245
+ + + + + W EI E+ S LLQ +
Sbjct: 3524 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3580
Query: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7300
+ S + Q+ T L K + + +++ Q+ + LL GL +K D +
Sbjct: 3581 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3640
Query: 7301 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7354
+ + E +K + + A ++ L L++ L + + LC ++ +L Y
Sbjct: 3641 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3699
Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
ET ++L+G++ S + Q R +ELK + ++ LD LN
Sbjct: 3700 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3734
Query: 7415 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7468
E+ L P +E K + N + L+S T++ ++ + +L+ Q F + +
Sbjct: 3735 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3794
Query: 7469 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7526
+ ++ +TE+KL +I Q + + F E+ + I+ ++ G +++
Sbjct: 3795 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3854
Query: 7527 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
+++ KL + + + + +R ++ ++ E E+L WL E +
Sbjct: 3855 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3913
Query: 7587 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
+ +P P + TL + + ++ + + +I + LL G
Sbjct: 3914 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3964
Query: 7645 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7701
E IQEK+ +A +++E KK A L + D ++++ +++ + L
Sbjct: 3965 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4023
Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7750
+ AE + KE + + + D+ +L L +TL A D I +
Sbjct: 4024 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082
Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7810
++++ + WE + + R ++ + + F + L + + + D
Sbjct: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4142
Query: 7811 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
I+ + K +++ +EEI QE + +G L A E ++ + ++N W
Sbjct: 4143 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4202
Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7924
L R+ KL+E + A Q + ++ W+ +LA PI D E +++
Sbjct: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4259
Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
++ E ++ + + + + + + E+LL +++ ++Q L W ++
Sbjct: 4260 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4316
Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
+ R+ K+E +F WL +E + G + EL K
Sbjct: 4317 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4376
Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
Q V + +E +NK L + + A +L+ + NQRW N+ ++ ++L
Sbjct: 4377 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4436
Query: 8105 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8164
+ Q + F + + WLT+ + L + AK +QL + + K E
Sbjct: 4437 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4495
Query: 8165 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8221
++ +G+Q++ + I+++++ L+ + V E
Sbjct: 4496 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4536
Query: 8222 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
L++R+ +LE++ L+ + +H+ D + Q L+++ L +D+
Sbjct: 4537 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4584
Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD-----HSALESQI 8335
+ + D + ++ S + + D+ G K F + V L + S E +
Sbjct: 4585 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4643
Query: 8336 RQL---GKALDDSRFQIQQ--------TENIIRSKTPTGPELDTS------------YKG 8372
++L G++LDD+R + +Q E + S+ EL+ + +K
Sbjct: 4644 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4703
Query: 8373 YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 8432
+ K LG S D+ R LKE+ + L + + + D+W+ + +++ ++
Sbjct: 4704 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVERQ 4760
Query: 8433 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8492
++++ L QF L ++ WL E +L + Q + DI + I K QK +
Sbjct: 4761 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKEL 4818
Query: 8493 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
R + + ++ + E + +S ++ ++ +++ RW+ VC+L + L+ AL Q
Sbjct: 4819 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4878
Query: 8553 QGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
+ FH + H LL L ++ R + ++P D + L D HK+ M+ +L E + +
Sbjct: 4879 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELN 4934
Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
M +L K + +I R + +L +H + L L ++Q+L
Sbjct: 4935 KATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4993
Score = 290 bits (741), Expect = 6e-77
Identities = 817/4617 (17%), Positives = 1774/4617 (38%), Gaps = 529/4617 (11%)
Query: 1370 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1427
S L S+ S LE K + E E+ +KEA SEI + K ++ ++ Q
Sbjct: 669 SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 724
Query: 1428 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1487
KL +T + ++ + +F S +W+ EKE+E A + S + I++ K
Sbjct: 725 AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 778
Query: 1488 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1541
++E++ K +I ++E A+ Q + AR I+A ++ + + Q
Sbjct: 779 DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 835
Query: 1542 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1596
C+E H+ + + E +++ + K A+ K C ++ +K+ +QE M
Sbjct: 836 CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 891
Query: 1597 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1646
+ + L S I A+ ++ N D ++ + ++ +Q E + + E
Sbjct: 892 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 951
Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1705
A + A W+ + + + + E A+R+ E + Q + L +E
Sbjct: 952 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 1009
Query: 1706 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1754
VVS +++ +++ S +VAS +K M + L L R+ D +
Sbjct: 1010 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1061
Query: 1755 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1814
+ +S V +L +V K + EL ++E + V + + +EV
Sbjct: 1062 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1113
Query: 1815 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1873
+ + L++ + L + + + +DLH + + +L +E ++ + + EF
Sbjct: 1114 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1173
Query: 1874 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
A+ S + L + Q + SM+ D + K +N L+N +A E A V L
Sbjct: 1174 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1230
Query: 1928 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1984
Y K+ E + + I+NL+ T + SE D + A +
Sbjct: 1231 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1273
Query: 1985 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2038
D+ ++ K+I D +T KER KE Q +++ V Q+++ L L
Sbjct: 1274 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1325
Query: 2039 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2094
+ K + + P +D I ++E T +R I ENQ + + Q +
Sbjct: 1326 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1380
Query: 2095 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
+ SK+ E T+KD E + ++ K K++ + S ++
Sbjct: 1381 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1437
Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
E + + +LV T M + D ++LEE L + + E++ W
Sbjct: 1438 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1493
Query: 2214 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2260
+N P + IS+ + + E+L + ++ A +++ + N+
Sbjct: 1494 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1553
Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
L++ K L+ +L F E+ +++L+ ++ +V K K + + ++ + I
Sbjct: 1554 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1610
Query: 2321 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
T+ E L+ + + LKK + Q+ELQ + + + E
Sbjct: 1611 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1670
Query: 2377 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2430
L + LI K +EA QL K + S +E L+K + +++E E K +
Sbjct: 1671 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1729
Query: 2431 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2457
+ S+R G +V+E Q N+L++
Sbjct: 1730 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1789
Query: 2458 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2487
DGQ S+ AV TQ Q L +LS + +Q+
Sbjct: 1790 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1849
Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
+ + ++ L + K + EL F+ + + W+ + E+ ENL
Sbjct: 1850 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1907
Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2605
I ++ + + F S D +S +G L ++ G+ + + CS+
Sbjct: 1908 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1958
Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2661
+ +E R A +L + +K + D+ E L E
Sbjct: 1959 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2018
Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
S+ + ++ + K Q SS + ++ E L + ++ +
Sbjct: 2019 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2078
Query: 2722 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
Q TL+ ++ ++ D + N+ E + + L Q GL E + +++S L
Sbjct: 2079 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2135
Query: 2782 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2818
E ++ AL +I+K+ L + +T D S + Q ++K
Sbjct: 2136 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2195
Query: 2819 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2874
+F++ KE + K+EE+ ++ + + +L + + L D +
Sbjct: 2196 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2255
Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
+Q E ++ ++ L + SL E+ + S L+ + L +K+ E
Sbjct: 2256 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2311
Query: 2935 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2973
D++ + + SC E L ++ + + F + L ++LE
Sbjct: 2312 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2369
Query: 2974 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
L + W+ + L+ T + + G +L+ + TE+
Sbjct: 2370 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2428
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+ L +D++ S L L L+ N + Q+ ++ QW
Sbjct: 2429 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2482
Query: 3080 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3136
L +N T + P + V T +++ + F +E + +K+ + K ELL
Sbjct: 2483 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2542
Query: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
+A + +T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 2543 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2602
Query: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3252
D ++Q++Q +L+E +PQ +L Q + S R
Sbjct: 2603 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2662
Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
+++ ++ ++ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++
Sbjct: 2663 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2722
Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3371
++ + + + Q+++ Q+K+ E + E + + +QL+ + +
Sbjct: 2723 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2782
Query: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
+ L+ A + +Q R F W+D+ + N+S A+L +++
Sbjct: 2783 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2842
Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3485
K ++ + + S + E +G + +E QL+L ++ + ++ KE
Sbjct: 2843 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2902
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEG 3545
K ++ + +Y+ ++ W+ + Q L++ A E ++ L+ LQ +
Sbjct: 2903 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQH 2961
Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLR 3601
++ + +T ++ + + + + +SL Q +L + N+ K +
Sbjct: 2962 FGMVELLNNTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3019
Query: 3602 LMEQKFQQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEE 3657
++ ++ L+ A+E++ S ++ SN+ +Q Q + + A + +V+
Sbjct: 3020 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDL 3074
Query: 3658 VGARAQEILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
AQ+++ E S S + Q + + L QV E+ FLE ++Q + ++++
Sbjct: 3075 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3134
Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
+ ++A +T+ K+ +T++ LK +E L ++ + +
Sbjct: 3135 REMFSQFAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKT 3188
Query: 3775 VKYLEEGEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
K + E +++++ +Q +L + +E + +EF K K +
Sbjct: 3189 CKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3248
Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQ 3888
+ + +E ME QL+ +K Q+ + + + V G+ L++
Sbjct: 3249 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3308
Query: 3889 DVT----LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
T L+ +D + + ++ L + L+ + + L+ + W++
Sbjct: 3309 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-E 3367
Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
LVA ++ + + Q+ K + + + + ++ +G+ + A + K
Sbjct: 3368 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKV 3423
Query: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
+ L + A+ + A+ + LE +TL+ WL+ ++ L
Sbjct: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
Query: 4065 PPLSRAEAIKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNA 4102
++ +Q+ +AL++ +R D++ S D S
Sbjct: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQV 3543
Query: 4103 SVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRR 4159
+ + ++Q L A+ + E+ + +E+ L D + + ++
Sbjct: 3544 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3603
Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
SEL V Q ++K QA +N + E + + T E ++ + ++
Sbjct: 3604 QSELR-------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYK 3655
Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVH 4274
D+ + S ++ E+ LQ R H C + +V +E + E L +A +
Sbjct: 3656 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3715
Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
+ LKK A + K ++ L + ++E + +E +++ + +R+ + D I +
Sbjct: 3716 PKELKKEA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772
Query: 4335 KIQ-VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
K++ + L Q+ EL W E + + D L E
Sbjct: 3773 KVEEIDAAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831
Query: 4394 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4453
+ + ++ L+K ++M E+Q ++K L + + + + +R L +A S
Sbjct: 3832 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3891
Query: 4454 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4513
QF + + + + I L + + +Q + + + + ++ + +
Sbjct: 3892 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3951
Query: 4514 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4573
G +L+ E++ E + K ++Y + + R L++ + F + D+
Sbjct: 3952 NKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4010
Query: 4574 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
L++ ++ E ++ Q+++ +N+ + + L TL++ G+ ++
Sbjct: 4011 ILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4070
Query: 4634 NEVDHSY----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLS 4688
D + +KL+ + + I L +++ K+ + + LA K + + L ++
Sbjct: 4071 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIK 4129
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPW 4747
+ + F+R + P + Q+ I +E+ GL E +D +N E + G+P
Sbjct: 4130 DTQ-DFIRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD 4187
Query: 4748 QP---DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
+P + L + + L + + R+ LE+ A +++ Q + + + + +
Sbjct: 4188 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4247
Query: 4805 NE-----ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQI 4858
+ ET+ + E+LK + S A Q I ++R+ E L L + E +H +
Sbjct: 4248 SPIGTDLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTV 4301
Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLD 4914
Q ELKL+ ++ E + + ++ ++ FQ + L WL + LS +
Sbjct: 4302 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4361
Query: 4915 LNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD 4974
+ + I+ E+ K + Q +V + + A++ + + +++L++ L L++
Sbjct: 4362 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4421
Query: 4975 GDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENL 5032
++ E R+ L Q + ++ + WL D + L LA L E+A+E L
Sbjct: 4422 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQL 4480
Query: 5033 KSHME----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
HME F + E+ + S +++ ++A + + +++Q + +L+ + + +
Sbjct: 4481 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETK 4536
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEH 5145
+ L+ ++ + ++ I + E+ L S SL+ + + + EH
Sbjct: 4537 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEH 4592
Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
K + VNS E+I+ L++ + L+ + + +V RW ++ ++ +
Sbjct: 4593 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4652
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
L+DA F+ K E +++ + L ++ T L H F L +
Sbjct: 4653 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4712
Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKD 5324
S + S+ E+ L + + D +++K T GK V+++ K
Sbjct: 4713 SVYDTTNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKL 4763
Query: 5325 REMV------ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKM 5377
E + + ++ W+ Y P + D + ++ +++ NH+
Sbjct: 4764 EEALLFSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK------ 4812
Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
+K LG T S+Q AL R+ I+ + K QELS + + +
Sbjct: 4813 ---AFQKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4860
Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
+ T+L+A EE L+E A ++ L +G L
Sbjct: 4861 CALSISKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD- 4908
Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHG 5552
+ L + H++ +++ E + ++LN+A + + + + + I WI +
Sbjct: 4909 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 4968
Query: 5553 TIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRE 5612
+AW Q R L + ++ LEA+ LQ+ + T+K + + + E
Sbjct: 4969 VLAWAKQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---E 5019
Query: 5613 TEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
EE++ +I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 5020 IEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5076
Score = 235 bits (599), Expect = 2e-60
Identities = 796/4534 (17%), Positives = 1666/4534 (36%), Gaps = 676/4534 (14%)
Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 631 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 686
Query: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 687 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 732
Query: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 733 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 787
Query: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 788 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 838
Query: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 839 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 897
Query: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
+S + + + +T+ + +I ++ AN
Sbjct: 898 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 957
Query: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
+A K C ++ E Q++ L LW HE
Sbjct: 958 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1016
Query: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 1017 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1070
Query: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 1071 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1123
Query: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 1124 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1182
Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 1183 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1237
Query: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 1238 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1293
Query: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 1294 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1353
Query: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 1354 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1411
Query: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 1412 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1457
Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
+ D+L++ E + L+ + E +++L + +S
Sbjct: 1458 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1498
Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 1499 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1552
Query: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
Query: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1672
Query: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 1673 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1727
Query: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 1728 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1787
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 1788 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1844
Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 1845 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1904
Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
++ T L + K +E+V+S+ L I + G + E
Sbjct: 1905 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1964
Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 1965 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2024
Query: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
+ + D + L + + LQ + Q + + T E D S +P
Sbjct: 2025 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2079
Query: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
D + L+ + ++ ++E + + + ++ ++ +W+ E + + +
Sbjct: 2080 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139
Query: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
N + + + +++ + + + + ++ ++ + ++ QA L++
Sbjct: 2140 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2199
Query: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
R+ + L +++ L+ +++ E L ++ + + ++
Sbjct: 2200 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2259
Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
M + LE K +E HSLLK G + K L + L K + KE+
Sbjct: 2260 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 2311
Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
T++++ + F K+L WI E + + + +P + L K
Sbjct: 2312 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2370
Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
LQ+ P ++ V G +L L+ VT
Sbjct: 2371 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2430
Query: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
+K + + Y+DL + K+ + L K+ + E + +WL +M+
Sbjct: 2431 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2490
Query: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
P +T +++T +Q K
Sbjct: 2491 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2550
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
M+ EI LN L + + + +++L +A+LKQ + + G
Sbjct: 2551 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2610
Query: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
+ +T ++ Q L LQ+ +R+ +Q A A Q L + P R +Q+
Sbjct: 2611 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2664
Query: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
A+ ++ + L CD + A VK+T Q +++ KL N +
Sbjct: 2665 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2719
Query: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
+ L+ A + Q +++ +++ +AQ + + VK+ + +A ++ +E
Sbjct: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2776
Query: 4196 VNKLTKKEESPEHKEINHLN----------------DQWLDLCRQSNN------------ 4227
+ K K E + HL WLD ++ N
Sbjct: 2777 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL 2836
Query: 4228 -LCLQREEDLQRTRDYHDCM--------------------NVVEVFLEKFTTEWDNLARS 4266
++ +D +T M +++ L T WD +
Sbjct: 2837 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2896
Query: 4267 DAESTAVHLEALKK--------------------------LALALQERKYAIEDLKDQKQ 4300
E E+L+K L E + +I LK ++
Sbjct: 2897 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK 2956
Query: 4301 KMIEHLNLDDK------------ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4348
+M +H + + E+ KE + + Q D++ ++ LE +
Sbjct: 2957 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT- 3015
Query: 4349 VQSRFQELMEWAEEQQPNIAEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIK 4406
+F+E E ++E + + A +Q D +Q +L + + LK +
Sbjct: 3016 --QKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3073
Query: 4407 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4466
A R+ DL V++ + S S V + + Q L++ + EK FL Q
Sbjct: 3074 LAKRLAQDL------VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3127
Query: 4467 SQIQQHERKI--MFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMK 4522
Q R++ F E L V + +T + + ++K + ++ L A K
Sbjct: 3128 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3187
Query: 4523 E-----VTEQEKSEVLG---KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4574
TE+ +++G L+ L + +L + R +++E + + F +
Sbjct: 3188 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3247
Query: 4575 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILP 4631
L++A+ + + E+ ++ QL ++ + Q E E L Q GQ ++
Sbjct: 3248 SILLQKAEEHEESQGPVGMETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQ 3305
Query: 4632 S-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4690
S L L+ + ++ + + ++QEA+L + +E + +
Sbjct: 3306 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3365
Query: 4691 EAQFLRMSKVPTDLAVEEA-LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQP 4749
E + V +A + Q + +LD+ V+ + ++ E +T +P
Sbjct: 3366 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADK 3422
Query: 4750 DKMLHLVTL----YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4805
K+L ++L + L + E R LE + Q+ + + L L ++ E+ VN
Sbjct: 3423 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVN 3480
Query: 4806 EETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS---- 4860
E + + KL+ + +L+D I + + L L+ + + +QS
Sbjct: 3481 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
Query: 4861 ---WQGELKLLTSAIGETVTE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL 4915
W E++ + + E + + C +++ F + ++WL V +LS D
Sbjct: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDY 3595
Query: 4916 NLQDIQEEIRKIQIHQEEVQSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELS 4971
+ + + ++ ++++ QE++ LR N L+ E K T E++ ++ L +
Sbjct: 3596 STEGLWKQQSELRVLQEDI--LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIK 3651
Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEE 5030
DI + TL + +R + + WL+ + ELL L E A +
Sbjct: 3652 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3711
Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSG 5090
E + L+ L+ + + L L+ +E LE+ VA R + +S
Sbjct: 3712 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Query: 5091 AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
+V+ + + + +A + + + +TEKKL ++ + +L K
Sbjct: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTM 3830
Query: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
+ + I L + ++ ++ K ++ + + V + + + + ++ LE A
Sbjct: 3831 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3890
Query: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
F ++ + + Q + A L E H + + + +
Sbjct: 3891 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3950
Query: 5271 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5330
+ + +L+ +PGE + ++ A ++E VK + + +
Sbjct: 3951 MNKTGPQLLE----LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 4006
Query: 5331 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEK 5384
+I+ + ++ E L P I A++E+++ ++E N ++EK+ +++ E+
Sbjct: 4007 KIDQILESLERIVERLRQPP-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4065
Query: 5385 YLGLYTILPSELSLQLAEVALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
+ ++S + + LD + I + I ++E E EL+ +K D
Sbjct: 4066 MIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHM 4122
Query: 5443 TILTKLKAKTD-------------NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ 5489
+++ +K D V Q + + + EE+DG +L + + +
Sbjct: 4123 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 4182
Query: 5490 NGQLGKPLAKK-IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 5548
G+ KP+ KK I +L + ++R+ KL +A +Y + L+ + W++
Sbjct: 4183 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD---- 4238
Query: 5549 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
+A G +A S S + + +EE K+ S EA ++++ E+++ Q
Sbjct: 4239 IAGGKLA--SMSPIGTDLETVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAEL 4287
Query: 5609 LGRETEELRQMIKIRLQNLQDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L ++ E + +QD ++K E + Q LE A L +
Sbjct: 4288 LLKKVTE-----ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342
Query: 5665 LKEQLSHRQHLLSEMESL--KPKVQAVQLCQSALRIPEDVVASLPLCHAALR-------- 5714
L L+H + LLSE + + PK ++L + + + DV+A A +
Sbjct: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIES 4401
Query: 5715 -LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------- 5763
EEAS LQ+ Q + + EQ +Q++ + +G H EIED
Sbjct: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
Query: 5764 -----KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
KP+ + + Q++ H E+ + +E SL K + + + +
Sbjct: 4462 HLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4520
Query: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
++ L E E ++ +L + + + ++L + + E T + S
Sbjct: 4521 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS---- 4576
Query: 5879 CRSPSPVANTDA-SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 5937
PS + +T +++ + +++ R Q ++ + + + F + L
Sbjct: 4577 --RPSLILDTVLFQIDEHKVFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLL 4632
Query: 5938 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5997
+Q WE + + E+ R+L +A +R +++ ++ + +E E L E P+
Sbjct: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPD 4692
Query: 5998 ---SQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
+Q+A+H+ + L + + + + L ++ AD + L L L+ L ++
Sbjct: 4693 KIKTQLAQHKE-FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKW 4749
Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
TI K+ ++ LEE L L + ALQ L WL + L P
Sbjct: 4750 DTICGKSVERQNKLEEAL---LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVH 4798
Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
+D+ L+D + K + + + L+EG ++D++ + +++ L
Sbjct: 4799 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELST 4855
Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQ 6225
+ KQ ++ ++ EE + A + EWLA+A T
Sbjct: 4856 RWETVCALSISKQTRLEAALRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDED 4910
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
++ + Q KE ++L E+++ L + G+ +L
Sbjct: 4911 ALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4944
Score = 224 bits (570), Expect = 4e-57
Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)
Query: 500 LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 551
L+K + EL +L L E S + W+ K + + Q + + +E +K
Sbjct: 2454 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2513
Query: 552 FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
FE Q Q LK ++ + EA + + E ++W+ L+ +
Sbjct: 2514 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2573
Query: 608 LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 654
LEE +N ++ A L+ WL + E MLN + +
Sbjct: 2574 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2633
Query: 655 QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 711
Q+ + AG ++ D + +K+QL + +W L ++ D+
Sbjct: 2634 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2693
Query: 712 EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 761
+Y + +LS ++ KLS L VS MN +L + Q+++ ++++ V A
Sbjct: 2694 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2753
Query: 762 --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 814
+ K +L + S Q EG K K + + ++ C S ++ S+
Sbjct: 2754 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2813
Query: 815 IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 871
L+ +++ + K++ + +++ + + S L Q H ++ +A EN L L
Sbjct: 2814 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2869
Query: 872 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 931
+GS+ + L+ + ++D +Q+ + + ++K +K+ VET + K
Sbjct: 2870 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2927
Query: 932 FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 989
+ + E++ L A EG + L + + F ++ N+ L C+ +++
Sbjct: 2928 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986
Query: 990 PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1046
++ + +Q+ +LH + L+ ++ E R L +E +LD
Sbjct: 2987 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3043
Query: 1047 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1106
L Q S K + + + + + ++ L + L L V D+ GT V L+
Sbjct: 3044 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3098
Query: 1107 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1164
E A ST + +++ + + + F + I +Q E A G
Sbjct: 3099 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3158
Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
++ K+ ET+ +L+ L ++S + A K + + LV + ++
Sbjct: 3159 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3209
Query: 1225 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1265
E K + D Q +E +K LEE S KE + Q ++T
Sbjct: 3210 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3268
Query: 1266 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1321
E + + + + +++ + + K++DV Q + Q+ H +L + +
Sbjct: 3269 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3327
Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1379
L + ++ ++Q L RF+ E+++ ++ T ++++ S + + + +++
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3386
Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1437
++ K + + E + +E +I P +K + +Q + + + L + E
Sbjct: 3387 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3446
Query: 1438 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1494
+ +E + F E L+ W+T EK L + T +S ++ QI+Q K +I
Sbjct: 3447 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3506
Query: 1495 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1554
+ + QS + + +++KL + + E++E + + L
Sbjct: 3507 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3566
Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1607
+ F E+ ++ ++E DKL+ + + +TE +VLQE D+ +++
Sbjct: 3567 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3623
Query: 1608 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1665
A+ ++ + + + A++ +Y+DI + + + LE L +RL
Sbjct: 3624 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3683
Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
TWL++ E + S E + + +++ + L+ E + + L ++ +L
Sbjct: 3684 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3742
Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
+ + ++ + + +ER+R + I +++ + + + QQFD+ + WI
Sbjct: 3743 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3802
Query: 1786 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
+L + +I + Q + L K E+ K + L K+ + E+ ++
Sbjct: 3803 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3862
Query: 1844 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
K + + ++ Q+ R L L S + +F +++ L L + Q++ +
Sbjct: 3863 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3921
Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1957
E + + + + Q + + +D + L++ E AD L
Sbjct: 3922 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3981
Query: 1958 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2017
+++ EA + + F D+ +++L+S+E I ER + + ++++
Sbjct: 3982 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4038
Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2071
+ + ++ + LK + +++ KD++ A V +++++ W++
Sbjct: 4039 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4097
Query: 2072 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2121
L+ E + + +++L ++ ++ S ++ + T I+D ED +
Sbjct: 4098 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4148
Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2177
K ET + +++ Q++LD + G L++ K I + + +S
Sbjct: 4149 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4208
Query: 2178 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2237
W D +KLEE M + ++ D + + D ++ + + M+ ++L+ + E L
Sbjct: 4209 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4264
Query: 2238 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2294
K+F+SE + + +E L+ + + L K + D ++ LM+ KL + +E
Sbjct: 4265 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4321
Query: 2295 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2349
+ L+ Q + ++++ W T E L + E L K +Q ++
Sbjct: 4322 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
Query: 2350 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2408
+ QS + + + N L E +L + L ++ + V + + + L +L
Sbjct: 4382 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4441
Query: 2409 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
K F +++ Q+W + S G + + +L+ + + + ++
Sbjct: 4442 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4501
Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
Q+GQ + A K ++I + I E++++ + + K L++ + F + +
Sbjct: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4561
Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
W+ + E+ N + + + HKV F E+ + RE + +L + G L +
Sbjct: 4562 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4617
Query: 2588 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2643
Q+ L LL S Q+ +++ E+ RS A + + EA + W++
Sbjct: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677
Query: 2644 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2702
+ L D ++ +L+Q ++ G + G ++S +
Sbjct: 4678 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4737
Query: 2703 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2762
+ L L++ W I SV Q+ LE + + + L W+ V+ ++
Sbjct: 4738 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4797
Query: 2763 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2821
+ L+D+ ++ E T ++ L +REL E +D S+ +EL T++
Sbjct: 4798 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4857
Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
+ ++ K ++E ++ + VH +WL A++ L + D A + +
Sbjct: 4858 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4917
Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
+ KE + E + L++ ++ V + + +RA ++E+ + +
Sbjct: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4974
Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
+ L S +A G +A+ ++ LE A L+ WA+ T L K D+E++
Sbjct: 4975 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 5017
Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
QEI E++K+ + E F +++ V + K Y
Sbjct: 5018 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5051
Score = 210 bits (535), Expect = 4e-53
Identities = 144/429 (33%), Positives = 219/429 (51%), Gaps = 65/429 (15%)
Query: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
R+ DE++ VQK+TFTKWIN HL K + V+DL+ED++DG L++LLEVLSG LP E+
Sbjct: 68 RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 125
Query: 80 GRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELT 139
GR R H + N+ AL +L+ R++KLVNI + DI DG P + LGL+WTIIL+FQI ++
Sbjct: 126 GRM--RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 183
Query: 140 SNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE 199
V+ E+ +AK+ LL W Q GI
Sbjct: 184 -------------------VTGESEDM------------SAKERLLLWTQQATEGYAGIR 212
Query: 200 VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPE 259
++F WR G F+++IH RP+L+D+ TV +SN NLE AF +AE ++G+ RLLDPE
Sbjct: 213 CENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPE 271
Query: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
DVDV PDEKS++TYV+ +P + +G +++ + + N V + R
Sbjct: 272 DVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYLIQWIRHH 330
Query: 320 FKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHLIQPLHRD 375
M ER + L ++Y FK + + K K++ L++
Sbjct: 331 VTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEF 384
Query: 376 GKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVH 435
G++ L Q ++ +W G + + E ALR E+ ++
Sbjct: 385 GRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPEVERLEML 426
Query: 436 EETANTIQR 444
++ AN +QR
Sbjct: 427 QQIANRVQR 435
Score = 162 bits (411), Expect = 1e-38
Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)
Query: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 1049 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1106
Query: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 1107 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1166
Query: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 1167 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1211
Query: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1262
Query: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 1263 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1322
Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 1323 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1382
Query: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 1383 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1442
Query: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 1443 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1502
Query: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
EK + S QK S KE +T L +K +
Sbjct: 1503 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1562
Query: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 1563 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1622
Query: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 1623 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1676
Query: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 1677 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1736
Query: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
W+ ++ + H + T
Sbjct: 1737 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1796
Query: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 1797 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1856
Query: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 1857 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1916
Query: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 1917 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1976
Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 1977 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2035
Query: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 2036 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2092
Query: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 2093 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2152
Query: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 2153 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2212
Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 2213 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2267
Query: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 2268 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2326
Query: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 2327 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2384
Query: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
+ S+ NL + A A T+ E SI++ ++
Sbjct: 2385 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2444
Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2504
Query: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 2505 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2564
Query: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 2565 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2624
Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 2625 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2684
Query: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 2685 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2740
Query: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
V E DLS ++ +A S EG + KD + +
Sbjct: 2741 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2795
Query: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
SA S Q +Q+ + A D++ + Q + I +K L +K + K L S
Sbjct: 2796 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2855
Query: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
+ ++ E+ L + + S + L +T W+ Q +E ++K++L+K
Sbjct: 2856 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 2910
Query: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
++ + ++W W+ + LE+ ++ D E I KLK LQK +D ++
Sbjct: 2911 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2967
Query: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
+N + + + D + + D V L + L++ + + F E+S
Sbjct: 2968 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3027
Query: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
L E +D + SN +LQ K L +KH++ L QD+
Sbjct: 3028 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 3084
Query: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
+ +++GT + +V I L ++V LE KL + Q + S
Sbjct: 3085 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3141
Query: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
DELD+ V GR QK
Sbjct: 3142 AEFDDELDSMAPV----GRDAETLQK 3163
Score = 96.3 bits (238), Expect = 1e-18
Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)
Query: 6806 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 650 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 702
Query: 6863 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6922
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 703 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 754
Query: 6923 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 755 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 806
Query: 6983 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 7041
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 807 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 864
Query: 7042 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7099
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 865 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 917
Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7154
+T + + +I + D +SH+ + I+ EA
Sbjct: 918 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 977
Query: 7155 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 978 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 1037
Query: 7209 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7253
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 1038 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1097
Query: 7254 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7293
Q++ EDR ++ +D + V I + L K L
Sbjct: 1098 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1156
Query: 7294 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 1157 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1213
Query: 7354 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7407
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 1214 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1273
Query: 7408 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7456
+L + + + KE ++ L W + Q R L+ L
Sbjct: 1274 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1333
Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 1334 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1389
Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1390 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1434
Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
+ E L V + Q + D ++ E+
Sbjct: 1435 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1470
Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7692
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1471 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1524
Query: 7693 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7750
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1525 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1572
Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7806
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1573 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1624
Query: 7807 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7852
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1625 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1684
Query: 7853 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7905
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1685 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1744
Query: 7906 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7930
SE A K ++ S EE Q LN+Q
Sbjct: 1745 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1804
Query: 7931 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7985
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1805 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1863
Query: 7986 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 1864 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1922
Query: 8045 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8092
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 1923 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1982
Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8146
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 1983 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2040
Query: 8147 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8204
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 2041 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2100
Query: 8205 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 8260
++KL ++ L R L ++D L W SL P S+ L
Sbjct: 2101 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2150
Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 8319
+++ + E+ +S+++ ++ ++ M PS Q KD R
Sbjct: 2151 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2200
Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
+ S H +++ +L ++ ++ + + +KT E+D K +L
Sbjct: 2201 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2259
Query: 8380 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
S LEHK E SL ++ H + A V+++ L + E +K+
Sbjct: 2260 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2317
Query: 8439 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 8475
++ F + S+ +W+ +T ++ LE ++L+ +
Sbjct: 2318 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2377
Query: 8476 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 8520
+T E+Q L L AV I ++ + + E T +++E +
Sbjct: 2378 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437
Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
+ ++ ++ ++ + LL++ L L + Q E S ++ L+ +++ +
Sbjct: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497
Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
+ D E ++ +Q + EL ++ +V L+D +LL E D EA
Sbjct: 2498 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2547
Query: 8641 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 8685
R K +L E+ +EL +L L+ SS+ + L W EL S +
Sbjct: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2606
Query: 8686 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 8745
P S PN T R + + + P LS PG S RG + L
Sbjct: 2607 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2664
Query: 8746 RA 8747
A
Sbjct: 2665 AA 2666
Score = 54.7 bits (130), Expect = 4e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 366 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 4640 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4688
Query: 425 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 4689 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4732
Query: 479 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
Query: 525 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 4793 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4847
Query: 585 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
Query: 639 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
Query: 692 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
Query: 747 QD----LEDIEQRVPVMDAQYKIITKT 769
+ +E++ ++ P +D +TKT
Sbjct: 5028 AEHQTFMEEMTRKQPDVDK----VTKT 5050
Score = 33.9 bits (76), Expect = 7.3
Identities = 90/474 (18%), Positives = 181/474 (38%), Gaps = 61/474 (12%)
Query: 8169 QGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 8228
Q +QL+++ A + +E+ LR C V+ + + +L + L+ +
Sbjct: 498 QADQLVQR-----VAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ 552
Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
+ S L SL SS+++ L+ + S + TPA P
Sbjct: 553 TLHPSLTSGL------TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS----- 601
Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG--DHSALESQI-----RQLGKA 8341
L + S + E Q K +R + S D + E +I + L
Sbjct: 602 -GLVPNFSSGV------EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 654
Query: 8342 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
+D+ + Q+ +TE S P+ ++K + + E SS+ E K+ E + +
Sbjct: 655 VDEMQVQLDRTE--WGSDLPSVESHLENHKNVHRAIEEFESSLK-----EAKISEIQMTA 707
Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8461
P + A + R E A+ L+ +++L F S + WL + EE
Sbjct: 708 P-------LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
Query: 8462 ELEQLQRLELSTDIQTIELQIKKLK----ELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
E E++ D I + K EL + +D ++ I S+ + + +
Sbjct: 761 E-------EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPAR 813
Query: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHG--LLLMLENIDRRKNE 8575
++ + M +W + L + +++ + F++ L L++ +RK
Sbjct: 814 LTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK-- 871
Query: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDC 8628
D + L+D ++ M+ K ELL+ + +A+L + ++ + +DC
Sbjct: 872 -YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 924
Score = 33.5 bits (75), Expect = 9.6
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 375 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
Query: 427 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 4793 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4851
Query: 484 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 4852 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4911
Query: 536 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 4912 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4955
Query: 592 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 4956 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4998
Query: 652 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 4999 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5049
Query: 712 EY 713
Y
Sbjct: 5050 TY 5051
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 372 bits (955), Expect = e-102
Identities = 717/4026 (17%), Positives = 1587/4026 (39%), Gaps = 438/4026 (10%)
Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 1463 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1519
Query: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1520 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1578
Query: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
T +V +Y+ G S +R +SL E ++ E +K +
Sbjct: 1579 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1636
Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1453
+K+A + P +KQ K E++ ++ L E ++T+++ K D +
Sbjct: 1637 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1690
Query: 1454 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1506
E + E + L L+ S ++ D+++ + + QE + KL I L +
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750
Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1566
++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1751 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1807
Query: 1567 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1626
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1808 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1849
Query: 1627 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1673
A++++ E + +++ +E +T +ENLL ++K+ + T +
Sbjct: 1850 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1905
Query: 1674 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1713
G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1906 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1965
Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1966 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 2023
Query: 1774 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1828
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 2024 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 2083
Query: 1829 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
K+ + ++ A D F+ V+ L L + Q
Sbjct: 2084 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 2140
Query: 1877 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1930
+ S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++ +
Sbjct: 2141 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2199
Query: 1931 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1988
A+ L S + + T D + G E + + + + + QD +
Sbjct: 2200 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2259
Query: 1989 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
E+L + ++E ++ ALQ + LE ++ + + + +K K+ +
Sbjct: 2260 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2319
Query: 2049 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
D + A + ++ L + + E + L + ++NL + LE +
Sbjct: 2320 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2379
Query: 2108 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2162
+ T + KD +L Y Q+ F KHL S LK+I S
Sbjct: 2380 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2425
Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2216
+ +D ++K ++S+K +E D ++ + V S +++++ + +
Sbjct: 2426 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2479
Query: 2217 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2269
+ + + + + AE+L K E K + +L+ E+ KVN+ L L +
Sbjct: 2480 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2538
Query: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2328
TP AK I V G + + +T E+F + T +++ +
Sbjct: 2539 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2580
Query: 2329 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
+ + L +KD EL ++ S + QE +++ + + T
Sbjct: 2581 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2639
Query: 2389 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2448
EAV KTQ +S E +++ + QE L+ KL +
Sbjct: 2640 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2673
Query: 2449 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
L + + T A KQ+ +T+ + ++Q + + +Q
Sbjct: 2674 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2710
Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2711 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2768
Query: 2569 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2624
+ ++L+ GQ +LS G G + QL Q +T + C A+
Sbjct: 2769 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2828
Query: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2682
+ + L+S+ + + ++L+ + + D + ++L Q + + + + ++K+
Sbjct: 2829 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2888
Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2889 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2947
Query: 2743 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2793
+ W+++ +Q HP+ + LD L+S++ + +D ++ L +
Sbjct: 2948 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2998
Query: 2794 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y + V
Sbjct: 2999 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 3057
Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
W+ Q L +IK +D E G + +++++SL E+ Q+
Sbjct: 3058 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 3099
Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
EL++ +L + + ++ V L V + + + Q +
Sbjct: 3100 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3157
Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
+F + K +QL + + + + + L LQ + + LK Q++ R +
Sbjct: 3158 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3217
Query: 3031 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3071
+DL + G + +E++ L Q + C E LQ +
Sbjct: 3218 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3277
Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3131
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 3278 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3337
Query: 3132 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3191
L+ GI+ + A + +E +E ++++F + L K
Sbjct: 3338 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3391
Query: 3192 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3246
E+ HE S + + QQ + + EP L+ K Q + W GQ +A
Sbjct: 3392 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3445
Query: 3247 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 3446 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3505
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
++ + P+++ V+ ++ + + L + +++ +++I GE + P I +
Sbjct: 3506 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3565
Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
QL + W +LL+ QLEG + + + + W+ ++E L E +
Sbjct: 3566 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3625
Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3475
+ + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3626 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3685
Query: 3476 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3532
IQE++ ++ + + + D WL + +KL + SV + ++ L
Sbjct: 3686 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3745
Query: 3533 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
R LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3746 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3803
Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWHEE 3647
+ R + +++ WL E E +S T+ + Q+ ++KK +
Sbjct: 3804 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3863
Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
A D + EV + E++ +R G + + RY+ + + ++++ ++ I
Sbjct: 3864 NKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3920
Query: 3706 SLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
++ + + + W T K + + + D+ + +K T+E+L +
Sbjct: 3921 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKD 3975
Query: 3763 LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3822
++ + G + + E E + ++K++ ++ + + ++ LE+ L +F
Sbjct: 3976 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 4035
Query: 3823 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
+ + L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G
Sbjct: 4036 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 4095
Query: 3883 LLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
LLEL + ++++K + Y + K+ +L+ + ++ ++ ++ + L +
Sbjct: 4096 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 4155
Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC------ 3994
+ RL P + ++ +E I +Q++ +K + ++ + L+ +G+ +I +
Sbjct: 4156 IVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4214
Query: 3995 --ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
A +Q KL Q N+H ++ + + A++ + H+S T++
Sbjct: 4215 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIK 4267
Query: 4047 QCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLS 4100
Q ++ ++ P ++PS + AE I++ LQE+ ++L L + C +
Sbjct: 4268 DTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPD 4325
Query: 4101 NASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4156
VK + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 4326 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4385
Query: 4157 KRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHL 4214
++LE + + ++K F + +Q + + + L KK EES +H + L
Sbjct: 4386 SPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 4443
Query: 4215 NDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4271
+ W L + N + E L + ++ + +L +
Sbjct: 4444 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 4503
Query: 4272 AVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE 4329
A+ +E K L + + +E + +IE ++ ++ + L QRW +
Sbjct: 4504 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4563
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ +++ Q L + ++L +W + + ++ + P+ A+ L H+
Sbjct: 4564 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4623
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+C+ EAK+ KSL++ +++A + I + +++ + + + +R+ L
Sbjct: 4624 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4683
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4509
+AL+ +F ++ + + Q E+ + L+ D V Q+ K + +++ +
Sbjct: 4684 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4743
Query: 4510 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4569
+ L G L +Q+ + L +QS ++ V+Q+ R + L+ K F E
Sbjct: 4744 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4803
Query: 4570 DFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTI 4629
+ K WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4804 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4863
Query: 4630 LPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L
Sbjct: 4864 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4923
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTG 4744
+E Q V D ++ ++L D +A E+ +V L + EG R
Sbjct: 4924 RVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4981
Query: 4745 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
W +M L T + + + + + LE +E + L L + EQ+
Sbjct: 4982 S-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLR 5038
Query: 4805 NEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4859
LP +E + + L++ L + T + + P + +H I
Sbjct: 5039 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 5098
Query: 4860 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4919
+ + + + + S + I Q + L WL+ + L+ D + +
Sbjct: 5099 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEV 5153
Query: 4920 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
I +EI +++ E Q+ + M + +K TK + +AD + + LD
Sbjct: 5154 IPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG 5212
Query: 4980 ALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLA 5019
R ++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 5213 RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFA 5272
Query: 5020 GNGLDV 5025
D+
Sbjct: 5273 NFDFDI 5278
Score = 340 bits (873), Expect = 3e-92
Identities = 720/4013 (17%), Positives = 1591/4013 (39%), Gaps = 492/4013 (12%)
Query: 442 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 1290 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1347
Query: 502 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
K++ + L +L AE+ +K + K E+V + ++N +S + E
Sbjct: 1348 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1404
Query: 551 KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
+ F E ++ ++ K E + D E+A+ +++ +W+N+ V++
Sbjct: 1405 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 1457
Query: 603 SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
+ LE + + Y +T L W++ E NQ EN+K + N +
Sbjct: 1458 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1517
Query: 657 HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
M + + E S +K L +++ + + VK+ D +
Sbjct: 1518 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1574
Query: 710 KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
+E+ D +A T +++ ++ + ++K L ++ + +E+ + K + K
Sbjct: 1575 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1630
Query: 770 AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
I+K + ++ GK F+ E+++ KE S L Q L
Sbjct: 1631 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1690
Query: 819 ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
ELEKQ+ + +S + +E+Q+S K + + + Q+ K+ L
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750
Query: 871 ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
+I G+ ++K+ + L+ D + +A++ ++ +K+ G+
Sbjct: 1751 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1809
Query: 919 -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
K +E +L K E+S+ EL+KV+ A +E E+ ++L T
Sbjct: 1810 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1869
Query: 965 EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
+ + LD +L D+ ++ + +Q +++ H Q D + E +
Sbjct: 1870 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1921
Query: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
LL +D + + + +E + ++ K EKII +H+ V + + L EK+
Sbjct: 1922 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1973
Query: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
Q + EE K ++ +++ L E + T+ L E+ +K+ DYT
Sbjct: 1974 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 2025
Query: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
EF W+ +E +L+ ++ A D ++KR + ++ +G+ S +VL
Sbjct: 2026 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 2085
Query: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
S + + + KL + +L S+ + +N D V + +++
Sbjct: 2086 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 2145
Query: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
L++G + + A K L +E + + L ++TK + + Q + + ++
Sbjct: 2146 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2204
Query: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
L D L ++ TLD L +S + ++Q+TL + + + ++ +
Sbjct: 2205 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2264
Query: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
+ SS + L+ ++L+ +S + ++ + R SI E VK+ E P
Sbjct: 2265 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 2322
Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
LQ + K + + + +E + ME +KTK + F + E L ++ K + L
Sbjct: 2323 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2382
Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
++ + ++ + E + L + + + A + K +
Sbjct: 2383 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 2442
Query: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
+ +E+ + + + + Q F+ ++ ++ + E
Sbjct: 2443 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 2502
Query: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
ED + K E KV + LC + ++++ A +A S V+N +
Sbjct: 2503 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2562
Query: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
S ++ + YED+ K++ L L+ Q+ ++E S+ + WL+
Sbjct: 2563 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2622
Query: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
+ A+ + D A + +VE L+ V KL +L E
Sbjct: 2623 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2682
Query: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLF 1784
K M L ++D +W++L Q+ R L+ QF + W+ +L
Sbjct: 2683 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2739
Query: 1785 LSELQTTS-----------EISIMDHQVALTRHKDH------AAEVESKKGELQSLQGHL 1827
+S L S ++ I+ + A TR + + S+ GE SL+G +
Sbjct: 2740 VSVLGPLSIDPNMLNTQRQQVQILLQEFA-TRKPQYEQLTAAGQGILSRPGEDPSLRG-I 2797
Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA---------------- 1871
K + L G+ D ++A + Q L L+
Sbjct: 2798 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2857
Query: 1872 --------EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAA 1923
+ L++ + ++Q ++ ++ ++ ++ S L++++ A + ++ LE
Sbjct: 2858 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGIL 2916
Query: 1924 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD-------AL 1976
S + KA+ H+ + S A++ Q Q L TK+ E + L
Sbjct: 2917 KSFKDVEQKAENHV-----QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2971
Query: 1977 AVLKKAFQDQKE--ELLKSIEDIEERTDKE------RLKEPTRQALQQRLRVFNQLEDEL 2028
VL+ +D K+ + L + + E+T E + + + ALQ +L D
Sbjct: 2972 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 3031
Query: 2029 N----SHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE---VTWDDTK--------RL 2073
N E++L +KA + ++ P +D+ N LE D + +
Sbjct: 3032 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 3091
Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSK-----VLENASSVIVTRTTIKDQ--------ED 2120
+ + Q G+++L+ N +V + V + S+I + +Q E+
Sbjct: 3092 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3151
Query: 2121 LKWAFSKHE----TAKNKMNYKQKDLDNFTSKGKHLLS---------------------E 2155
+ F + + +K ++ ++ LD S G S +
Sbjct: 3152 MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3211
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
L K + D + +D + T D L V E + + L + L T+ + G N
Sbjct: 3212 LAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQN 3270
Query: 2216 CVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2268
+ +M + D+ L R E L++ + +K +LE L + ++ + K +
Sbjct: 3271 TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM 3330
Query: 2269 ----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
ET PDL I+ DL + ++ + A+ A+ QVE I + +++K++
Sbjct: 3331 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTIKRLEEFYSKLK 3383
Query: 2325 E---SLMNCAQNETCEA------------LKKVKDIQKE----LQSQQSNISSTQENLNS 2365
E L ++E + L K QKE LQ +Q +++ + L
Sbjct: 3384 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQ 3443
Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFL 2423
K S + L + + + + +++ ++ A LQE+L F ++++ W +
Sbjct: 3444 SAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3501
Query: 2424 GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2483
+ + + KV++A++ + + + + D +S ++ + +EG+ +
Sbjct: 3502 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3561
Query: 2484 SIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTEN 2542
I +Q++ + ++A L + + L+ + F + LN W+ +E+R N E
Sbjct: 3562 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3621
Query: 2543 LGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
+G + E+ ++++ L + ++ +SL LS R E Q
Sbjct: 3622 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR------EDKDMVQSK 3675
Query: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
SQ+ + + + + Q AL + E + W+ + D+L+
Sbjct: 3676 LDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDY 3733
Query: 2656 SKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLK 2711
S + L K+ S++ +DILL K ++ A+ G + L+ + + +IQ +LE +K
Sbjct: 3734 STEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3789
Query: 2712 EVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI----------EHPLQ 2761
+ DI S TLE + +L W++ V+ ++ E Q
Sbjct: 3790 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3849
Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESFKDTAQEELKTQ 2820
Q KE + +++L + + AL L+ ++RE EK E +
Sbjct: 3850 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED---------NER 3900
Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
+ + +K+ +++ + + A W+ +++L D+ + T +L
Sbjct: 3901 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3960
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
K + EI + ++ + SG ++M + + K+ D V +
Sbjct: 3961 QVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 4009
Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD-EEIVECW 2999
+ + S+ L + V Q + E+ L ++ L + E + +
Sbjct: 4010 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 4069
Query: 3000 HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY---NCLCLQASK 3056
+ +++ + + + +P + + +L S G+ + ++Y + L Q +
Sbjct: 4070 EEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLYSQIKE 4123
Query: 3057 GCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3116
+ + L + ++ F + + + + + +S ++KI+E +SE++N
Sbjct: 4124 DVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4182
Query: 3117 GQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDWKNFHSNLHQKE 3165
+ + E L ++ + AK +Q K+ W+N H+ + ++E
Sbjct: 4183 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4242
Query: 3166 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHC 3225
+ L ++ + F + + T+ + + + D +++Q+ +++ EEI
Sbjct: 4243 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDG 4302
Query: 3226 YEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3283
+ +L+ + +L G+ + + +L+S + +L+ K+++ +L+ +
Sbjct: 4303 LQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAV 4362
Query: 3284 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
Q+ G++ + DW+ A L S +D + + +L+ S +++I+M+ + +
Sbjct: 4363 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4422
Query: 3344 GESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E +L+ + E T+Q L +K +W SL I + +LEGAL +Q + +
Sbjct: 4423 AELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4482
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYV- 3461
W+ E L+E + + + L K +L +VL++ S +E + G + E
Sbjct: 4483 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4542
Query: 3462 -----TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD 3516
Q +L+ L +R++ + E+ ++ + + +R + + +++ + WL + L
Sbjct: 4543 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4602
Query: 3517 QYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALE 3573
L G T + L E+ + S++ + ++ AE D+ +
Sbjct: 4603 ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN 4662
Query: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
+L++ W++ + +L+E +T+ +N Q WL AE+ ++ +R T
Sbjct: 4663 NLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT 4722
Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLL 3691
Q+ + K + EV ++R+++ E+ + S + + + SR++ ++
Sbjct: 4723 VLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQ 4782
Query: 3692 QVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLK 3748
+++E+ + L++ + ++ + S +W + K+ + +A DK+ T +L
Sbjct: 4783 RLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKT-----QLA 4837
Query: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV---- 3804
+ K + HS+ + G R++K + L+ + D + +L++ T+
Sbjct: 4838 QHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSELRDKWDTICGKS 4894
Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
+ LE+ L + +F+D +AL W+ + L + ++ + +K+ Q+
Sbjct: 4895 VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQK 4954
Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
+ SV++++ L+E +D + +K ++ +L + ++ +C++ LEA ++
Sbjct: 4955 ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 5014
Query: 3923 DHEDYNSELQEVEKWLLQMSGRL----VAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
E+++S + + +WL + L V PD + +L T+ Q HK M+++
Sbjct: 5015 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPD--DEDALRTLIDQ---HKEFMKKLEEKRA 5069
Query: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
LN GDT++ C +K + + + + + A++ Q L L
Sbjct: 5070 ELNKATTMGDTVLAICHPDSITTIKHWITI----IRARFEEVLAWAKQHQQRLASALAGL 5125
Query: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4091
+++Q+ L+ AWL + L + + ++++ +AL + +T+++
Sbjct: 5126 IAKQELLEALLAWLQWAETTLTDKDKEVIP-----QEIEEVKALIAEHQTFME 5173
Score = 320 bits (819), Expect = 5e-86
Identities = 790/4278 (18%), Positives = 1616/4278 (37%), Gaps = 541/4278 (12%)
Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1337
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 1183 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1242
Query: 1338 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1387
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 1243 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1299
Query: 1388 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1447
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 1300 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1358
Query: 1448 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1507
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 1359 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1414
Query: 1508 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1540
Q S F T E +I +L + G+ L+ +
Sbjct: 1415 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1474
Query: 1541 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 1475 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1527
Query: 1598 LCQAL-ESLSSAITAFS-----------ASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1645
CQ E S+ + + + + V R A + Q++ D+ +
Sbjct: 1528 ECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL----RT 1583
Query: 1646 RQTALENLLAHW--------QRLEKELSSFLTWLERGEAKASSPEMDIS-ADRVKVEGEL 1696
R TAL L+ + +RLE+E S + KA + +S + + E
Sbjct: 1584 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1643
Query: 1697 QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKR 1756
+ +S +K QL E+L ++ +L L + ++ D +
Sbjct: 1644 AGKPPFSKQKISSEEISTKKEQLSEALQTI---------QLFLAKHGDKMTD------EE 1688
Query: 1757 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESK 1816
N L+ V Q+ LL S S+ L E QT+ ++ + + ++ R +++ +++
Sbjct: 1689 RNELEKQVKTLQESYNLLFSESL---KQLQESQTSGDVKV-EEKIVAERQQEYKEKLQGI 1744
Query: 1817 KGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
L + L +G E + G E +++ Q L + +Q
Sbjct: 1745 CDLLTQTENRL-----IGHQEAFMIGDGTVE------------LKKYQSKQEELQKDMQG 1787
Query: 1877 HA-SLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKAL----ESAAVSLDGIL 1930
A +L+ +++ + E +++ + LIE+ LN+A + L E + LD ++
Sbjct: 1788 SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1847
Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL------------------------ 1966
+ A ++ T A QL +I+NLL
Sbjct: 1848 TTA--------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1899
Query: 1967 GTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2023
GT E D K A ++ E LL++ D + T +E L + ++ Q ++ +Q
Sbjct: 1900 GTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1955
Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT-------KRLIHE 2076
+ + + + L+ + + ++ ++ ++ + + L+V ++ +L H
Sbjct: 1956 HQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTHS 2012
Query: 2077 NQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
Q + E+++ + LEN A + T +K Q+ H+
Sbjct: 2013 LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG-- 2070
Query: 2133 NKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRL 2192
DL T G +L K D V T +V KL+ DR
Sbjct: 2071 --------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHR-----EVQRKLDHATDRF 2117
Query: 2193 RVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISNLDNHL------------RA 2233
R S + D++ E S + + + HL R
Sbjct: 2118 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2177
Query: 2234 EELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEIT 2292
E K + ++ ++ + +E+L L + +L D+Q D++ + E +
Sbjct: 2178 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2237
Query: 2293 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ---NETC--EALKKVKDIQK 2347
L+ +S V+ ++++ W VE SL Q N T + + K +++
Sbjct: 2238 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2297
Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
++ +QS+I++ E + + SL M L + S +T A ++E
Sbjct: 2298 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2357
Query: 2408 EK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
K E++ E + FL K A D G V E + +Q + + L+ +
Sbjct: 2358 TKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY-MQESTSEFLEHKKHLEVL 2415
Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
+ + +H + + E+ +++F+ + K+A+ C +L +F+ +
Sbjct: 2416 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2475
Query: 2527 LNLWIHEMEER-------FNTENLGESKQHIPE-------KKNEVHKVE---MFLGELLA 2569
L WI E ++ F E+LG+S + + K E+ KV + L L++
Sbjct: 2476 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2535
Query: 2570 A----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-----------HQNLLRMTKE 2614
A +++ + G +L+ EG E ++ LTS +++L + K+
Sbjct: 2536 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2595
Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
K+ L + + +E +M W++ + + T DT + Q+
Sbjct: 2596 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQN---KS 2652
Query: 2675 GEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLETLKEVWADIMSSSVHAQSTL 2728
E E+K N+ + + + L +E + L + W ++ ++ Q L
Sbjct: 2653 FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL 2712
Query: 2729 ESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDH 2786
E + + + QL+QW+ + + PL P + +Q +L E
Sbjct: 2713 EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN--TQRQQVQILLQEFATR 2770
Query: 2787 TRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDIMT-VAKEKMRKVEEIVKDH 2842
+L A + + + ED S + +E+L TQ D +T ++ +++ +
Sbjct: 2771 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2830
Query: 2843 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELI--DSREIGASRL 2897
Y + +D L +L +S A ++L K+K+ I + ++I ++
Sbjct: 2831 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQ- 2889
Query: 2898 SRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2956
+ E L+ VK+ E + E+ + L K ++D + ++ +++L S A S Q
Sbjct: 2890 ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2942
Query: 2957 EFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLEGKNTDEEIVECWHKGQEIL 3006
+Q F A L T ++ L +LE D + Q +
Sbjct: 2943 --------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2994
Query: 3007 DALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
AE LK+Q +E L+T K+ + +E L+
Sbjct: 2995 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV-----------KERENKLK 3043
Query: 3067 QRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNISEVST--SLQK-IQEFLSES 3114
+ KA + +Q W+ + + C D + + ++ SLQK + +
Sbjct: 3044 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 3103
Query: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
E + N +LS E+ ++T E IQ KV E LH K+ LEN+ +
Sbjct: 3104 ELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-------LHSKKFCLENMTQK 3155
Query: 3175 MKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNR 3232
K+F EVS E + E++ +H+S L + LQ+ + + + Q++
Sbjct: 3156 FKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3212
Query: 3233 LKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3289
K AQ L + SK +V ++ ++ LS EK S L+ + F I
Sbjct: 3213 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3272
Query: 3290 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKLEALLSVKQEKEIQMKMIVT 3342
+E+ + LDS D L + KLEAL++ KM++
Sbjct: 3273 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3332
Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E TSP+ + I++ L+++ LL + Q+EG + + + +++FS
Sbjct: 3333 TEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3386
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSYSSLLETIEVKGAGM----- 3456
+ E + E L K+ EE+ + + G G+
Sbjct: 3387 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3446
Query: 3457 --TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK 3514
T + +L D+ R++ + ++ + + ++ + +Q L++ W+ +E
Sbjct: 3447 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3506
Query: 3515 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3574
+ + + +++ + LQ + ++ + + E + + P + + L+
Sbjct: 3507 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3566
Query: 3575 LR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNR 3631
L W+A ++ Q + + + + ++EWL T E+++ +
Sbjct: 3567 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3626
Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------DESHVNSRMG------CQA 3679
+ E Q+ Q K +++ + + + + Q + D+ V S++ +
Sbjct: 3627 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3686
Query: 3680 TQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
+ + LL Q L K F E+E++ + +W H ++ +
Sbjct: 3687 QEKSHSRSELLQQALCNAKIFGEDEVELM-----------NWLNEVHDKLSKLS--VQDY 3733
Query: 3739 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3798
T + K+ L VL +D+ + A G +K E ++ ++ + K
Sbjct: 3734 STEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3793
Query: 3799 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3858
++T TLE+ L LA+ + L W+ + + L E ++ E +
Sbjct: 3794 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3853
Query: 3859 YKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKIDQLQSDYQDLCSIGKEHVF 3915
K L++ +++ + S+ E ALLELV L+ + + Y+ + + V
Sbjct: 3854 PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3913
Query: 3916 SLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAG 3975
++A + + ++ W+ + +L++ + +T + QL K EI
Sbjct: 3914 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3972
Query: 3976 FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL 4035
+D +++L G ++ C++ + +K+ + L+ +Y IC Y LE
Sbjct: 3973 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----NYDTICQINSERYLQLERAQ 4028
Query: 4036 QKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS 4095
+T ++ WL+ Q + P P L + + R QE+ R +L+
Sbjct: 4029 SLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EYETLRQQQEEHRQLRELIAE 4081
Query: 4096 MCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--- 4149
+ KT + ++ + +I++K V A L + +IK + + L +A
Sbjct: 4082 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YSQIKEDVKKRAVALDEAISQ 4138
Query: 4150 --------DQQLQNMKRRHSEL--------ELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
DQ L++++R L E+ + +S+ K+ ++ Q T+
Sbjct: 4139 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 4198
Query: 4194 EKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCLQREE---DLQRTRDYHDCM 4246
++ ++ + + K + DQ + + + L +RE D+ + C
Sbjct: 4199 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 4258
Query: 4247 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ------ 4300
++ + K T ++ D E + +K+ A + + I+ L+++
Sbjct: 4259 HMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4314
Query: 4301 -KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4359
++I DK +VK+ L W L K +I ++ Q Q + +W
Sbjct: 4315 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4374
Query: 4360 AEEQQPNIA----------------EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4403
+ +A E LKQ Q + M+ L +EL LLK
Sbjct: 4375 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL-----LLKK 4429
Query: 4404 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4463
+ +++D+ +Q L + + + L + + R+ L AL QF A+
Sbjct: 4430 VTEESDK----------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4479
Query: 4464 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE 4523
+ + + E + ++ + P + ++ Q + +Q+ V + G +L++
Sbjct: 4480 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4539
Query: 4524 VTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI 4583
+E S + KL+ L + +VL+K R Q+L+ L K F + + WL +
Sbjct: 4540 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599
Query: 4584 VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSE 4643
L QL + + E +L + GQ +L + + + +
Sbjct: 4600 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4659
Query: 4644 KLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD 4703
+N L ++ + ++ K++EA+ E+ + ++ L++ E Q L ++ P+
Sbjct: 4660 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE-QTLNVASRPS- 4717
Query: 4704 LAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ----PDKMLHLVTLY 4759
L ++ L D + +EV E + EL++ + Q + ++ + + +
Sbjct: 4718 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4777
Query: 4760 HRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 4811
++ ++ +R L+D A Q HE K+ + LE KS+ E N+ +T A
Sbjct: 4778 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4837
Query: 4812 EEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK 4866
+ K L HS+ + +G LK T +D K + + +
Sbjct: 4838 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---------KLDDMLSELRDKWD 4888
Query: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG--PVYLDLNLQDIQEEI 4924
+ E + E ++ S F + +DWL RV+ +L+ PV+ D++L + I
Sbjct: 4889 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL--VMNLI 4946
Query: 4925 RKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4984
+ Q+E+ + AL +E +++ S+ ++ + ELS + ++
Sbjct: 4947 DNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKVQMQELSTRWETVCALSISK 5005
Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL-KSHMEFFSTED 5043
Q L Q + ++ V A +WL +A++ L+ G D E A L H EF +
Sbjct: 5006 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 5065
Query: 5044 QFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQKVASLELRSQRMSRDSG-- 5090
+ + L + ++ T+ + P + E+ +A + QR++
Sbjct: 5066 EKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL 5125
Query: 5091 -AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEK 5141
A+ +LL+ A QW + K +E + + + + + ++E F T + ++
Sbjct: 5126 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5185
Query: 5142 LSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGNDASKATLSRSMTTVWQRWT 5193
+K + +S I L++ AS L +G+ T + + + +W
Sbjct: 5186 TKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQ 5245
Query: 5194 RLRAVAQDQEKILEDAVD 5211
++ +A ++ + L DA+D
Sbjct: 5246 QVWLLALERRRKLNDALD 5263
Score = 318 bits (815), Expect = 1e-85
Identities = 900/4830 (18%), Positives = 1875/4830 (38%), Gaps = 684/4830 (14%)
Query: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
V+ W+D M+ L+ +E ++L + L K ++ + + S L+ ++ MT
Sbjct: 786 VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 844
Query: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
L+L ++ +R + AK T + L LH R +WL +++E+
Sbjct: 845 ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 899
Query: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
Y E + + H +R+L + + + Q + +L P+ +
Sbjct: 900 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 956
Query: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
RA + W Q + + E F ++ ++L+ ++ +
Sbjct: 957 YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 1008
Query: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
+ R S+ E + + + EE+ Y+ + + +A+ I+ NS + +
Sbjct: 1009 KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 1068
Query: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
+ Y+ + + + + + + + ++ S +E+ + S +K +
Sbjct: 1069 PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 1128
Query: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
+A +I++ + + TL + +K + H L+ R ++K + GE
Sbjct: 1129 LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 1183
Query: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
++ L+ D +E +E + LEK +++ K++ YQE+L
Sbjct: 1184 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 1230
Query: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
E + E +S+ ++++ + + E ++ +R + E++ + + L
Sbjct: 1231 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1290
Query: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
K ++++L+ D + + +E FS A SEL V + + Q MS + D
Sbjct: 1291 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 1347
Query: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
L+T +L Q A + + EE A D+ NN++ TL Q + K +
Sbjct: 1348 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 1404
Query: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
Q HA L+ AI + Y+ + + H + D L + W + VQ D
Sbjct: 1405 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 1459
Query: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
L E I K +K++R ++ V+TT + IQ+ + +T
Sbjct: 1460 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1504
Query: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
+ +L Q + L EI+ +S++ + A+Q +K EL+ + MV +
Sbjct: 1505 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1559
Query: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
K + Q+S + II++ L + + + L Q++ S + E+ L+
Sbjct: 1560 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1614
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
+ H V K +W S+ T E K + Q K + E++
Sbjct: 1615 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1661
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
+K+++ E L L K ++ +LE +K T E N++ F E +
Sbjct: 1662 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1711
Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
+ +E Q + +++ + Q IC L + LI + M G
Sbjct: 1712 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1768
Query: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
E + Q +++ L K + Q L V + T + + +
Sbjct: 1769 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1810
Query: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
+E L+ +++ C+ Q +LK Q++ +EL K VT E EK
Sbjct: 1811 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1860
Query: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
+ +L+E ++ +++L K S R K ++ + HF+E + D+
Sbjct: 1861 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1920
Query: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
L + D+ N + + A+++ I+ Q ++ + L++ GQ + P
Sbjct: 1921 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1980
Query: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
E L + + L + +A ++ K + +QE + E+ ++ + Q
Sbjct: 1981 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 2036
Query: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
L LEA ++ + T L E+ +S + R I + EA +++ G
Sbjct: 2037 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 2096
Query: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
T + K+ H + L + + L+D YQ +E L L++ +
Sbjct: 2097 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2156
Query: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
SK E + + K L+ +L G + + LK+ L D L P A
Sbjct: 2157 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 2215
Query: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
+ + G + L+ ++ E + + + +S+ Q + LDW+ V++ L
Sbjct: 2216 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2275
Query: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
+ LN +Q+ I K + ++++ +NA++ K K+ ++ L+ + +L
Sbjct: 2276 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2335
Query: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
S + + A + E+ ++ + + + + +LE Q L ++ G DV
Sbjct: 2336 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 2393
Query: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
L +M+ ++E H +LE LHSL+ + P+ K + +K +L + + M
Sbjct: 2394 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2451
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
+ + + C Q +Q + + + +T KK+ F S E +KL E
Sbjct: 2452 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2511
Query: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
+L +S V + + I A++ + L E T + + ++
Sbjct: 2512 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2571
Query: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
+T++ + T + +D +L+D + E +K++KA E M+ LQ
Sbjct: 2572 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2631
Query: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
+ P + +A K T +E + +F EL+Q + + L+ + +L++ P E P
Sbjct: 2632 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2685
Query: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
Q +T + + + + + +++ + +T +K W+ E + LG
Sbjct: 2686 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2745
Query: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
+I+ ++ Q +++QILL E + E++ + G+ + + SL Q
Sbjct: 2746 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2801
Query: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
LA V + Q+ D+ ++Q+ S Q Q L + L+ L+ L K + +
Sbjct: 2802 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2857
Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
T + ++L+ E+ ++ L + L L++++ + +
Sbjct: 2858 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2917
Query: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
+ ++AEN + L A + ++ +M W++ K N + + +
Sbjct: 2918 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2971
Query: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
+ ++L+++ K+ L A + + + E + + G E L+ + N
Sbjct: 2972 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 3027
Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
K +K+ E +LK+ +LE+A L KEQ+ + L ++ + +
Sbjct: 3028 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 3070
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
+ ++ C E+ +A L LQ+E QH + + +++ +
Sbjct: 3071 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 3121
Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
E E K L Q ++ ++ K N+ QE+ + R + A++ +
Sbjct: 3122 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3181
Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
+ S K LTM L + LA+ GT D+ ++
Sbjct: 3182 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3241
Query: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
H ++ +C L + + + T E+ S A S +PV ++ +
Sbjct: 3242 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3301
Query: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
A+ + L A D A + E P L L L + L +
Sbjct: 3302 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 3360
Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
++ + ++R +++ L+ S I L+ +E E + P E++ Q M
Sbjct: 3361 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 3415
Query: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
++ ++EI LQ L + L+ + ++ + L+ L + R T+ K
Sbjct: 3416 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 3472
Query: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
+ + L+E L L R + AL+ L SW++ T+ + P E ++A
Sbjct: 3473 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3522
Query: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
Q L+D + VE+ KV L +LS+ + L KA
Sbjct: 3523 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3582
Query: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
T++ R+L+G + Q+ H+ + LN T EK + + TQ+ ++E
Sbjct: 3583 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3632
Query: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
+AQ + + K L Q ++ +SL + ++SR ++ ++Q E
Sbjct: 3633 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3687
Query: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
+ + ++L Q L K ED++ M W +H Q++ST+ Q + L
Sbjct: 3688 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3745
Query: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
QE +L + N LL+G+ L K + + L+ + +++++ S +
Sbjct: 3746 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3804
Query: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
Q++ L ++L+ TWLD VE L + L EE + L K+ K
Sbjct: 3805 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3864
Query: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
+D + N S A E G + V ED R L+ + Q+ ++
Sbjct: 3865 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3918
Query: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
+ + + F+Q ++ I + E L +E
Sbjct: 3919 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3952
Query: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
+ +LQV++ E+ + +D+ D+L+ + ++ ++K + ++ L++
Sbjct: 3953 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 4012
Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
+ + E+ E Q L+++ E ++ L LTET + IIS
Sbjct: 4013 ICQINSERYL--------QLERAQSLVNQFWETYEELWPW--LTET--QSIIS------- 4053
Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
+L A A LEY ET QQE RQL L+ E
Sbjct: 4054 ----QLPAPA-------------LEY--ETL----RQQQEEHRQLRE---------LIAE 4081
Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
++ + +N+ P+L + L G+ I ++ +Q+ E
Sbjct: 4082 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 4123
Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
+ K L+ + T++ + ++ L+ +RL +Q ++ E+E +++ ++
Sbjct: 4124 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 4178
Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
S +++ L ++ G +++ K + ++ +L ++ W ++ T +
Sbjct: 4179 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4238
Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
+ KL L + +L + MS I +++ D I + + + +
Sbjct: 4239 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4295
Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
+ +I+ Q +D V + + S+ + + DK + + +N +W L ++I
Sbjct: 4296 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4351
Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
LE +++ +Y++ +Q + W + +L IG D +V+ +++ + +
Sbjct: 4352 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4411
Query: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
++ E+E++ L++ E+ V L EL W +L+ + + L+ L
Sbjct: 4412 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4471
Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
+ A D++ ++L LS + + G +A+++++ LQ+D+ + +++
Sbjct: 4472 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4531
Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
N L++ L N L+ +N RW N+LE+ ++ Q L+ + K + +
Sbjct: 4532 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4588
Query: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
Q D LL + + A +++ ++ C T K L + G+Q
Sbjct: 4589 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4644
Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
+ + SA + I D +L + ++E L +++T L+ + F SL+ W+
Sbjct: 4645 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4704
Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
+AE+ L S L T+ +++E K + +S + L++ G L +++
Sbjct: 4705 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4763
Query: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
++NL W + + ER L + + F E ME+L ++E+ L +
Sbjct: 4764 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4823
Query: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
EI+ + + Q H+ FQ + ++ + + G+ L E+ + DD + + L+ L
Sbjct: 4824 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4883
Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
++W + ++ +R+ ++ + ++ + + L WL V ++ V +
Sbjct: 4884 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4942
Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
L D K F ++ G +V+A K+ L+ + ++ ++ E+ +W++
Sbjct: 4943 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4998
Query: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
++ +L L+ E+ + LE L ++ L LPD + L + K
Sbjct: 4999 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 5058
Query: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
E + +L + + + DT+ A D I+ + + +++ ++EE+ +Q++
Sbjct: 5059 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 5118
Query: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
L E + L WL E+ ++ +I + IE++K + + EE+
Sbjct: 5119 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5178
Query: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
Q + ++ + +R A SH ++IE K +VN
Sbjct: 5179 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5238
Query: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
+WQ + L R +KL + L +++L
Sbjct: 5239 LLVSKWQQVWLLALERRRKLNDALDRLEEL 5268
Score = 298 bits (763), Expect = 2e-79
Identities = 728/4019 (18%), Positives = 1555/4019 (38%), Gaps = 470/4019 (11%)
Query: 4948 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 1286 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1345
Query: 4999 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 5043
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 1346 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1405
Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5097
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 1406 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1465
Query: 5098 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5155
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 1466 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1522
Query: 5156 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5213
K+ ++ A Q T D T++ R+M Q+ + R + + I+++ +D
Sbjct: 1523 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1582
Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
T + V T+ I D L E+ S E + H EL++ S +
Sbjct: 1583 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1635
Query: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5327
+TL + P ++ +EI+ +++ + + K K+ +E + E
Sbjct: 1636 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1695
Query: 5328 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5387
V+T S E+ + L D ++EE + + + +E KEK G
Sbjct: 1696 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1743
Query: 5388 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5430
+ +L + + + + ++LK Q+++++ Q A T L
Sbjct: 1744 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1803
Query: 5431 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
+KL+++ + L + K K + + ++A+ +K L + + + E AAV++
Sbjct: 1804 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1863
Query: 5486 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5539
E ++ L + K +E H+Q I Q + S + E +E+ +
Sbjct: 1864 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1922
Query: 5540 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5596
L+ +V GT N Q ++ H+ ++ + + + + + EK S
Sbjct: 1923 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1979
Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
EK+ + + EL E + +++ ++++KF+A+ + + L+Q++ L
Sbjct: 1980 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 2039
Query: 5657 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5705
+ E G LK Q S + ++S L+ + ++ +S + V +
Sbjct: 2040 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 2099
Query: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5761
R + A+ + +CN++ + V +Y+ YE L
Sbjct: 2100 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 2148
Query: 5762 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5819
+ +Q +A S+H E +A K Q Q+ + ++ + ++ + V
Sbjct: 2149 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2196
Query: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5867
+++ AE D G LLP + + GR L V E S ++
Sbjct: 2197 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2256
Query: 5868 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5919
G N E S + P ++++I Q ++ + +A ++
Sbjct: 2257 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2314
Query: 5920 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5979
E +P S AK+ DL + + E + E + + +++ + + T +
Sbjct: 2315 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2374
Query: 5980 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 6039
E L+E PG+ Q E L + + E+ SL +E+ S +D A
Sbjct: 2375 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2433
Query: 6040 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6089
L + L+ + M TI+ K Q+L + L ++E ++ + +
Sbjct: 2434 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2493
Query: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
A++L L TK + E + + N++ + A++ +V +
Sbjct: 2494 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2551
Query: 6150 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6206
+L G+ + E A K L +K + ++ D L ++ E S +
Sbjct: 2552 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2611
Query: 6207 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6255
+S + +WL + T T+ +Q+ ++Q K E EL + + ++ + +
Sbjct: 2612 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2671
Query: 6256 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6299
E+L E + D E P D QEL + E+SS
Sbjct: 2672 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2725
Query: 6300 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6337
E+ +++ +++L+ +VL +++Q Q+L Y + G+
Sbjct: 2726 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2785
Query: 6338 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6394
G+ P+ + V L + Q ++ ++ Q Q+I + + + S L
Sbjct: 2786 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2844
Query: 6395 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6454
D++ +L + A+ T NQ++ + + +K + +QA E+ V
Sbjct: 2845 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2900
Query: 6455 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
E+ L L R +L S V Q+ + LQ + + + ++ +K
Sbjct: 2901 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2958
Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6558
P++ +++ ++ K+F + +K E ++
Sbjct: 2959 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 3018
Query: 6559 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6617
+L+ ++ +D + R + L ++L +Y+ ++ L ++ Q + + +
Sbjct: 3019 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 3078
Query: 6618 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6673
++ E I +L KE Q +L T + + KE T + L+ + V
Sbjct: 3079 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3138
Query: 6674 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6730
++ H + LE + + + E +E RQL+ + + S+G + L T
Sbjct: 3139 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3194
Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6786
+ Q + SL + ++ + L++ S SD+ Q+ + + + + ++ ++
Sbjct: 3195 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3254
Query: 6787 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6846
LET L+ +Q+ ++ D L+ V ++ E ++ F
Sbjct: 3255 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3310
Query: 6847 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
K+++A + + T +L ++ D ++ +L + Q LL A +E++
Sbjct: 3311 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3370
Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6960
+ +L + S++ + L++ + +E + + I++ L +K F+ + +
Sbjct: 3371 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3427
Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
KQ V+++ Q ++Q +++ ++ + L +N W+ L V ++ L+
Sbjct: 3428 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3482
Query: 7021 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
L +++ ++ L +W +T+E Q+ + V+ +++ + L+ L+ ++ VE
Sbjct: 3483 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3542
Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
I++ G + + ++ L L W L + L+ +
Sbjct: 3543 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3602
Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7199
+ +N +L L + ++ Q+ + L+DD+ + L + SI Q LK
Sbjct: 3603 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3661
Query: 7200 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7245
+ + + + + W EI E+ S LLQ +
Sbjct: 3662 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3718
Query: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7300
+ S + Q+ T L K + + +++ Q+ + LL GL +K D +
Sbjct: 3719 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3778
Query: 7301 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7354
+ + E +K + + A ++ L L++ L + + LC ++ +L Y
Sbjct: 3779 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3837
Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
ET ++L+G++ S + Q R +ELK + ++ LD LN
Sbjct: 3838 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3872
Query: 7415 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7468
E+ L P +E K + N + L+S T++ ++ + +L+ Q F + +
Sbjct: 3873 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3932
Query: 7469 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7526
+ ++ +TE+KL +I Q + + F E+ + I+ ++ G +++
Sbjct: 3933 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3992
Query: 7527 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
+++ KL + + + + +R ++ ++ E E+L WL E +
Sbjct: 3993 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 4051
Query: 7587 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
+ +P P + TL + + ++ + + +I + LL G
Sbjct: 4052 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 4102
Query: 7645 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7701
E IQEK+ +A +++E KK A L + D ++++ +++ + L
Sbjct: 4103 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4161
Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7750
+ AE + KE + + + D+ +L L +TL A D I +
Sbjct: 4162 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4220
Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7810
++++ + WE + + R ++ + + F + L + + + D
Sbjct: 4221 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4280
Query: 7811 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
I+ + K +++ +EEI QE + +G L A E ++ + ++N W
Sbjct: 4281 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4340
Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7924
L R+ KL+E + A Q + ++ W+ +LA PI D E +++
Sbjct: 4341 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4397
Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
++ E ++ + + + + + + E+LL +++ ++Q L W ++
Sbjct: 4398 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4454
Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
+ R+ K+E +F WL +E + G + EL K
Sbjct: 4455 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4514
Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
Q V + +E +NK L + + A +L+ + NQRW N+ ++ ++L
Sbjct: 4515 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4574
Query: 8105 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8164
+ Q + F + + WLT+ + L + AK +QL + + K E
Sbjct: 4575 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4633
Query: 8165 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8221
++ +G+Q++ + I+++++ L+ + V E
Sbjct: 4634 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4674
Query: 8222 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
L++R+ +LE++ L+ + +H+ D + Q L+++ L +D+
Sbjct: 4675 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4722
Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD-----HSALESQI 8335
+ + D + ++ S + + D+ G K F + V L + S E +
Sbjct: 4723 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4781
Query: 8336 RQL---GKALDDSRFQIQQ--------TENIIRSKTPTGPELDTS------------YKG 8372
++L G++LDD+R + +Q E + S+ EL+ + +K
Sbjct: 4782 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4841
Query: 8373 YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 8432
+ K LG S D+ R LKE+ + L + + + D+W+ + +++ ++
Sbjct: 4842 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVERQ 4898
Query: 8433 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8492
++++ L QF L ++ WL E +L + Q + DI + I K QK +
Sbjct: 4899 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKEL 4956
Query: 8493 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
R + + ++ + E + +S ++ ++ +++ RW+ VC+L + L+ AL Q
Sbjct: 4957 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 5016
Query: 8553 QGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
+ FH + H LL L ++ R + ++P D + L D HK+ M+ +L E + +
Sbjct: 5017 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELN 5072
Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
M +L K + +I R + +L +H + L L ++Q+L
Sbjct: 5073 KATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 5131
Score = 290 bits (741), Expect = 6e-77
Identities = 817/4617 (17%), Positives = 1774/4617 (38%), Gaps = 529/4617 (11%)
Query: 1370 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1427
S L S+ S LE K + E E+ +KEA SEI + K ++ ++ Q
Sbjct: 807 SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 862
Query: 1428 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1487
KL +T + ++ + +F S +W+ EKE+E A + S + I++ K
Sbjct: 863 AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 916
Query: 1488 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1541
++E++ K +I ++E A+ Q + AR I+A ++ + + Q
Sbjct: 917 DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 973
Query: 1542 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1596
C+E H+ + + E +++ + K A+ K C ++ +K+ +QE M
Sbjct: 974 CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 1029
Query: 1597 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1646
+ + L S I A+ ++ N D ++ + ++ +Q E + + E
Sbjct: 1030 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 1089
Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1705
A + A W+ + + + + E A+R+ E + Q + L +E
Sbjct: 1090 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 1147
Query: 1706 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1754
VVS +++ +++ S +VAS +K M + L L R+ D +
Sbjct: 1148 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1199
Query: 1755 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1814
+ +S V +L +V K + EL ++E + V + + +EV
Sbjct: 1200 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1251
Query: 1815 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1873
+ + L++ + L + + + +DLH + + +L +E ++ + + EF
Sbjct: 1252 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1311
Query: 1874 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
A+ S + L + Q + SM+ D + K +N L+N +A E A V L
Sbjct: 1312 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1368
Query: 1928 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1984
Y K+ E + + I+NL+ T + SE D + A +
Sbjct: 1369 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1411
Query: 1985 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2038
D+ ++ K+I D +T KER KE Q +++ V Q+++ L L
Sbjct: 1412 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1463
Query: 2039 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2094
+ K + + P +D I ++E T +R I ENQ + + Q +
Sbjct: 1464 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1518
Query: 2095 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
+ SK+ E T+KD E + ++ K K++ + S ++
Sbjct: 1519 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1575
Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
E + + +LV T M + D ++LEE L + + E++ W
Sbjct: 1576 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1631
Query: 2214 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2260
+N P + IS+ + + E+L + ++ A +++ + N+
Sbjct: 1632 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1691
Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
L++ K L+ +L F E+ +++L+ ++ +V K K + + ++ + I
Sbjct: 1692 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1748
Query: 2321 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
T+ E L+ + + LKK + Q+ELQ + + + E
Sbjct: 1749 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1808
Query: 2377 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2430
L + LI K +EA QL K + S +E L+K + +++E E K +
Sbjct: 1809 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1867
Query: 2431 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2457
+ S+R G +V+E Q N+L++
Sbjct: 1868 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1927
Query: 2458 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2487
DGQ S+ AV TQ Q L +LS + +Q+
Sbjct: 1928 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1987
Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
+ + ++ L + K + EL F+ + + W+ + E+ ENL
Sbjct: 1988 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 2045
Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2605
I ++ + + F S D +S +G L ++ G+ + + CS+
Sbjct: 2046 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 2096
Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2661
+ +E R A +L + +K + D+ E L E
Sbjct: 2097 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2156
Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
S+ + ++ + K Q SS + ++ E L + ++ +
Sbjct: 2157 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2216
Query: 2722 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
Q TL+ ++ ++ D + N+ E + + L Q GL E + +++S L
Sbjct: 2217 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2273
Query: 2782 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2818
E ++ AL +I+K+ L + +T D S + Q ++K
Sbjct: 2274 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2333
Query: 2819 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2874
+F++ KE + K+EE+ ++ + + +L + + L D +
Sbjct: 2334 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2393
Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
+Q E ++ ++ L + SL E+ + S L+ + L +K+ E
Sbjct: 2394 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2449
Query: 2935 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2973
D++ + + SC E L ++ + + F + L ++LE
Sbjct: 2450 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2507
Query: 2974 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
L + W+ + L+ T + + G +L+ + TE+
Sbjct: 2508 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2566
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+ L +D++ S L L L+ N + Q+ ++ QW
Sbjct: 2567 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2620
Query: 3080 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3136
L +N T + P + V T +++ + F +E + +K+ + K ELL
Sbjct: 2621 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2680
Query: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
+A + +T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 2681 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2740
Query: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3252
D ++Q++Q +L+E +PQ +L Q + S R
Sbjct: 2741 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2800
Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
+++ ++ ++ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++
Sbjct: 2801 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2860
Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3371
++ + + + Q+++ Q+K+ E + E + + +QL+ + +
Sbjct: 2861 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2920
Query: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
+ L+ A + +Q R F W+D+ + N+S A+L +++
Sbjct: 2921 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2980
Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3485
K ++ + + S + E +G + +E QL+L ++ + ++ KE
Sbjct: 2981 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 3040
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEG 3545
K ++ + +Y+ ++ W+ + Q L++ A E ++ L+ LQ +
Sbjct: 3041 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQH 3099
Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLR 3601
++ + +T ++ + + + + +SL Q +L + N+ K +
Sbjct: 3100 FGMVELLNNTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3157
Query: 3602 LMEQKFQQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEE 3657
++ ++ L+ A+E++ S ++ SN+ +Q Q + + A + +V+
Sbjct: 3158 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDL 3212
Query: 3658 VGARAQEILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
AQ+++ E S S + Q + + L QV E+ FLE ++Q + ++++
Sbjct: 3213 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3272
Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
+ ++A +T+ K+ +T++ LK +E L ++ + +
Sbjct: 3273 REMFSQFAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKT 3326
Query: 3775 VKYLEEGEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
K + E +++++ +Q +L + +E + +EF K K +
Sbjct: 3327 CKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3386
Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQ 3888
+ + +E ME QL+ +K Q+ + + + V G+ L++
Sbjct: 3387 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3446
Query: 3889 DVT----LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
T L+ +D + + ++ L + L+ + + L+ + W++
Sbjct: 3447 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-E 3505
Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
LVA ++ + + Q+ K + + + + ++ +G+ + A + K
Sbjct: 3506 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKV 3561
Query: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
+ L + A+ + A+ + LE +TL+ WL+ ++ L
Sbjct: 3562 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3621
Query: 4065 PPLSRAEAIKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNA 4102
++ +Q+ +AL++ +R D++ S D S
Sbjct: 3622 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQV 3681
Query: 4103 SVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRR 4159
+ + ++Q L A+ + E+ + +E+ L D + + ++
Sbjct: 3682 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3741
Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
SEL V Q ++K QA +N + E + + T E ++ + ++
Sbjct: 3742 QSELR-------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYK 3793
Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVH 4274
D+ + S ++ E+ LQ R H C + +V +E + E L +A +
Sbjct: 3794 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3853
Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
+ LKK A + K ++ L + ++E + +E +++ + +R+ + D I +
Sbjct: 3854 PKELKKEA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3910
Query: 4335 KIQ-VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
K++ + L Q+ EL W E + + D L E
Sbjct: 3911 KVEEIDAAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3969
Query: 4394 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4453
+ + ++ L+K ++M E+Q ++K L + + + + +R L +A S
Sbjct: 3970 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQS 4029
Query: 4454 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4513
QF + + + + I L + + +Q + + + + ++ + +
Sbjct: 4030 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 4089
Query: 4514 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4573
G +L+ E++ E + K ++Y + + R L++ + F + D+
Sbjct: 4090 NKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4148
Query: 4574 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
L++ ++ E ++ Q+++ +N+ + + L TL++ G+ ++
Sbjct: 4149 ILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4208
Query: 4634 NEVDHSY----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLS 4688
D + +KL+ + + I L +++ K+ + + LA K + + L ++
Sbjct: 4209 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIK 4267
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPW 4747
+ + F+R + P + Q+ I +E+ GL E +D +N E + G+P
Sbjct: 4268 DTQ-DFIRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD 4325
Query: 4748 QP---DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
+P + L + + L + + R+ LE+ A +++ Q + + + + +
Sbjct: 4326 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4385
Query: 4805 NE-----ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQI 4858
+ ET+ + E+LK + S A Q I ++R+ E L L + E +H +
Sbjct: 4386 SPIGTDLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTV 4439
Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLD 4914
Q ELKL+ ++ E + + ++ ++ FQ + L WL + LS +
Sbjct: 4440 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4499
Query: 4915 LNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD 4974
+ + I+ E+ K + Q +V + + A++ + + +++L++ L L++
Sbjct: 4500 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4559
Query: 4975 GDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENL 5032
++ E R+ L Q + ++ + WL D + L LA L E+A+E L
Sbjct: 4560 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQL 4618
Query: 5033 KSHME----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
HME F + E+ + S +++ ++A + + +++Q + +L+ + + +
Sbjct: 4619 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETK 4674
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEH 5145
+ L+ ++ + ++ I + E+ L S SL+ + + + EH
Sbjct: 4675 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEH 4730
Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
K + VNS E+I+ L++ + L+ + + +V RW ++ ++ +
Sbjct: 4731 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4790
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
L+DA F+ K E +++ + L ++ T L H F L +
Sbjct: 4791 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4850
Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKD 5324
S + S+ E+ L + + D +++K T GK V+++ K
Sbjct: 4851 SVYDTTNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKL 4901
Query: 5325 REMV------ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKM 5377
E + + ++ W+ Y P + D + ++ +++ NH+
Sbjct: 4902 EEALLFSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK------ 4950
Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
+K LG T S+Q AL R+ I+ + K QELS + + +
Sbjct: 4951 ---AFQKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4998
Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
+ T+L+A EE L+E A ++ L +G L
Sbjct: 4999 CALSISKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD- 5046
Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHG 5552
+ L + H++ +++ E + ++LN+A + + + + + I WI +
Sbjct: 5047 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 5106
Query: 5553 TIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRE 5612
+AW Q R L + ++ LEA+ LQ+ + T+K + + + E
Sbjct: 5107 VLAWAKQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---E 5157
Query: 5613 TEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
EE++ +I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 5158 IEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5214
Score = 235 bits (599), Expect = 2e-60
Identities = 796/4534 (17%), Positives = 1666/4534 (36%), Gaps = 676/4534 (14%)
Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 769 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 824
Query: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 825 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 870
Query: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 871 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 925
Query: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 926 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 976
Query: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 977 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 1035
Query: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
+S + + + +T+ + +I ++ AN
Sbjct: 1036 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 1095
Query: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
+A K C ++ E Q++ L LW HE
Sbjct: 1096 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1154
Query: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 1155 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1208
Query: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 1209 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1261
Query: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 1262 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1320
Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 1321 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1375
Query: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 1376 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1431
Query: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 1432 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1491
Query: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 1492 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1549
Query: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 1550 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1595
Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
+ D+L++ E + L+ + E +++L + +S
Sbjct: 1596 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1636
Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 1637 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1690
Query: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750
Query: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 1751 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1810
Query: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 1811 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1865
Query: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 1866 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1925
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 1926 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1982
Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 1983 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 2042
Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
++ T L + K +E+V+S+ L I + G + E
Sbjct: 2043 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 2102
Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 2103 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2162
Query: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
+ + D + L + + LQ + Q + + T E D S +P
Sbjct: 2163 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2217
Query: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
D + L+ + ++ ++E + + + ++ ++ +W+ E + + +
Sbjct: 2218 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2277
Query: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
N + + + +++ + + + + ++ ++ + ++ QA L++
Sbjct: 2278 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2337
Query: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
R+ + L +++ L+ +++ E L ++ + + ++
Sbjct: 2338 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2397
Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
M + LE K +E HSLLK G + K L + L K + KE+
Sbjct: 2398 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 2449
Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
T++++ + F K+L WI E + + + +P + L K
Sbjct: 2450 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2508
Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
LQ+ P ++ V G +L L+ VT
Sbjct: 2509 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2568
Query: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
+K + + Y+DL + K+ + L K+ + E + +WL +M+
Sbjct: 2569 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2628
Query: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
P +T +++T +Q K
Sbjct: 2629 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2688
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
M+ EI LN L + + + +++L +A+LKQ + + G
Sbjct: 2689 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2748
Query: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
+ +T ++ Q L LQ+ +R+ +Q A A Q L + P R +Q+
Sbjct: 2749 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2802
Query: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
A+ ++ + L CD + A VK+T Q +++ KL N +
Sbjct: 2803 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2857
Query: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
+ L+ A + Q +++ +++ +AQ + + VK+ + +A ++ +E
Sbjct: 2858 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2914
Query: 4196 VNKLTKKEESPEHKEINHLN----------------DQWLDLCRQSNN------------ 4227
+ K K E + HL WLD ++ N
Sbjct: 2915 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL 2974
Query: 4228 -LCLQREEDLQRTRDYHDCM--------------------NVVEVFLEKFTTEWDNLARS 4266
++ +D +T M +++ L T WD +
Sbjct: 2975 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 3034
Query: 4267 DAESTAVHLEALKK--------------------------LALALQERKYAIEDLKDQKQ 4300
E E+L+K L E + +I LK ++
Sbjct: 3035 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK 3094
Query: 4301 KMIEHLNLDDK------------ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4348
+M +H + + E+ KE + + Q D++ ++ LE +
Sbjct: 3095 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT- 3153
Query: 4349 VQSRFQELMEWAEEQQPNIAEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIK 4406
+F+E E ++E + + A +Q D +Q +L + + LK +
Sbjct: 3154 --QKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3211
Query: 4407 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4466
A R+ DL V++ + S S V + + Q L++ + EK FL Q
Sbjct: 3212 LAKRLAQDL------VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3265
Query: 4467 SQIQQHERKI--MFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMK 4522
Q R++ F E L V + +T + + ++K + ++ L A K
Sbjct: 3266 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3325
Query: 4523 E-----VTEQEKSEVLG---KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4574
TE+ +++G L+ L + +L + R +++E + + F +
Sbjct: 3326 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3385
Query: 4575 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILP 4631
L++A+ + + E+ ++ QL ++ + Q E E L Q GQ ++
Sbjct: 3386 SILLQKAEEHEESQGPVGMETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQ 3443
Query: 4632 S-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4690
S L L+ + ++ + + ++QEA+L + +E + +
Sbjct: 3444 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3503
Query: 4691 EAQFLRMSKVPTDLAVEEA-LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQP 4749
E + V +A + Q + +LD+ V+ + ++ E +T +P
Sbjct: 3504 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADK 3560
Query: 4750 DKMLHLVTL----YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4805
K+L ++L + L + E R LE + Q+ + + L L ++ E+ VN
Sbjct: 3561 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVN 3618
Query: 4806 EETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS---- 4860
E + + KL+ + +L+D I + + L L+ + + +QS
Sbjct: 3619 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3678
Query: 4861 ---WQGELKLLTSAIGETVTE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL 4915
W E++ + + E + + C +++ F + ++WL V +LS D
Sbjct: 3679 SQVWYIEIQEKSHSRSELLQQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDY 3733
Query: 4916 NLQDIQEEIRKIQIHQEEVQSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELS 4971
+ + + ++ ++++ QE++ LR N L+ E K T E++ ++ L +
Sbjct: 3734 STEGLWKQQSELRVLQEDI--LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIK 3789
Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEE 5030
DI + TL + +R + + WL+ + ELL L E A +
Sbjct: 3790 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3849
Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSG 5090
E + L+ L+ + + L L+ +E LE+ VA R + +S
Sbjct: 3850 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3909
Query: 5091 AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
+V+ + + + +A + + + +TEKKL ++ + +L K
Sbjct: 3910 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTM 3968
Query: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
+ + I L + ++ ++ K ++ + + V + + + + ++ LE A
Sbjct: 3969 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 4028
Query: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
F ++ + + Q + A L E H + + + +
Sbjct: 4029 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 4088
Query: 5271 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5330
+ + +L+ +PGE + ++ A ++E VK + + +
Sbjct: 4089 MNKTGPQLLE----LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 4144
Query: 5331 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEK 5384
+I+ + ++ E L P I A++E+++ ++E N ++EK+ +++ E+
Sbjct: 4145 KIDQILESLERIVERLRQPP-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4203
Query: 5385 YLGLYTILPSELSLQLAEVALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
+ ++S + + LD + I + I ++E E EL+ +K D
Sbjct: 4204 MIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHM 4260
Query: 5443 TILTKLKAKTD-------------NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ 5489
+++ +K D V Q + + + EE+DG +L + + +
Sbjct: 4261 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 4320
Query: 5490 NGQLGKPLAKK-IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 5548
G+ KP+ KK I +L + ++R+ KL +A +Y + L+ + W++
Sbjct: 4321 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD---- 4376
Query: 5549 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
+A G +A S S + + +EE K+ S EA ++++ E+++ Q
Sbjct: 4377 IAGGKLA--SMSPIGTDLETVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAEL 4425
Query: 5609 LGRETEELRQMIKIRLQNLQDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L ++ E + +QD ++K E + Q LE A L +
Sbjct: 4426 LLKKVTE-----ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4480
Query: 5665 LKEQLSHRQHLLSEMESL--KPKVQAVQLCQSALRIPEDVVASLPLCHAALR-------- 5714
L L+H + LLSE + + PK ++L + + + DV+A A +
Sbjct: 4481 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIES 4539
Query: 5715 -LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------- 5763
EEAS LQ+ Q + + EQ +Q++ + +G H EIED
Sbjct: 4540 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599
Query: 5764 -----KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
KP+ + + Q++ H E+ + +E SL K + + + +
Sbjct: 4600 HLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4658
Query: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
++ L E E ++ +L + + + ++L + + E T + S
Sbjct: 4659 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS---- 4714
Query: 5879 CRSPSPVANTDA-SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 5937
PS + +T +++ + +++ R Q ++ + + + F + L
Sbjct: 4715 --RPSLILDTVLFQIDEHKVFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLL 4770
Query: 5938 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5997
+Q WE + + E+ R+L +A +R +++ ++ + +E E L E P+
Sbjct: 4771 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPD 4830
Query: 5998 ---SQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
+Q+A+H+ + L + + + + L ++ AD + L L L+ L ++
Sbjct: 4831 KIKTQLAQHKE-FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKW 4887
Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
TI K+ ++ LEE L L + ALQ L WL + L P
Sbjct: 4888 DTICGKSVERQNKLEEAL---LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVH 4936
Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
+D+ L+D + K + + + L+EG ++D++ + +++ L
Sbjct: 4937 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELST 4993
Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQ 6225
+ KQ ++ ++ EE + A + EWLA+A T
Sbjct: 4994 RWETVCALSISKQTRLEAALRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDED 5048
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
++ + Q KE ++L E+++ L + G+ +L
Sbjct: 5049 ALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 5082
Score = 224 bits (570), Expect = 4e-57
Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)
Query: 500 LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 551
L+K + EL +L L E S + W+ K + + Q + + +E +K
Sbjct: 2592 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2651
Query: 552 FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
FE Q Q LK ++ + EA + + E ++W+ L+ +
Sbjct: 2652 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2711
Query: 608 LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 654
LEE +N ++ A L+ WL + E MLN + +
Sbjct: 2712 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2771
Query: 655 QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 711
Q+ + AG ++ D + +K+QL + +W L ++ D+
Sbjct: 2772 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2831
Query: 712 EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 761
+Y + +LS ++ KLS L VS MN +L + Q+++ ++++ V A
Sbjct: 2832 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2891
Query: 762 --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 814
+ K +L + S Q EG K K + + ++ C S ++ S+
Sbjct: 2892 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2951
Query: 815 IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 871
L+ +++ + K++ + +++ + + S L Q H ++ +A EN L L
Sbjct: 2952 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 3007
Query: 872 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 931
+GS+ + L+ + ++D +Q+ + + ++K +K+ VET + K
Sbjct: 3008 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 3065
Query: 932 FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 989
+ + E++ L A EG + L + + F ++ N+ L C+ +++
Sbjct: 3066 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 3124
Query: 990 PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1046
++ + +Q+ +LH + L+ ++ E R L +E +LD
Sbjct: 3125 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3181
Query: 1047 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1106
L Q S K + + + + + ++ L + L L V D+ GT V L+
Sbjct: 3182 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3236
Query: 1107 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1164
E A ST + +++ + + + F + I +Q E A G
Sbjct: 3237 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3296
Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
++ K+ ET+ +L+ L ++S + A K + + LV + ++
Sbjct: 3297 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3347
Query: 1225 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1265
E K + D Q +E +K LEE S KE + Q ++T
Sbjct: 3348 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3406
Query: 1266 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1321
E + + + + +++ + + K++DV Q + Q+ H +L + +
Sbjct: 3407 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3465
Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1379
L + ++ ++Q L RF+ E+++ ++ T ++++ S + + + +++
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3524
Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1437
++ K + + E + +E +I P +K + +Q + + + L + E
Sbjct: 3525 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3584
Query: 1438 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1494
+ +E + F E L+ W+T EK L + T +S ++ QI+Q K +I
Sbjct: 3585 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3644
Query: 1495 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1554
+ + QS + + +++KL + + E++E + + L
Sbjct: 3645 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3704
Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1607
+ F E+ ++ ++E DKL+ + + +TE +VLQE D+ +++
Sbjct: 3705 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3761
Query: 1608 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1665
A+ ++ + + + A++ +Y+DI + + + LE L +RL
Sbjct: 3762 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3821
Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
TWL++ E + S E + + +++ + L+ E + + L ++ +L
Sbjct: 3822 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3880
Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
+ + ++ + + +ER+R + I +++ + + + QQFD+ + WI
Sbjct: 3881 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3940
Query: 1786 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
+L + +I + Q + L K E+ K + L K+ + E+ ++
Sbjct: 3941 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 4000
Query: 1844 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
K + + ++ Q+ R L L S + +F +++ L L + Q++ +
Sbjct: 4001 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 4059
Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1957
E + + + + Q + + +D + L++ E AD L
Sbjct: 4060 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 4119
Query: 1958 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2017
+++ EA + + F D+ +++L+S+E I ER + + ++++
Sbjct: 4120 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4176
Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2071
+ + ++ + LK + +++ KD++ A V +++++ W++
Sbjct: 4177 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4235
Query: 2072 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2121
L+ E + + +++L ++ ++ S ++ + T I+D ED +
Sbjct: 4236 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4286
Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2177
K ET + +++ Q++LD + G L++ K I + + +S
Sbjct: 4287 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4346
Query: 2178 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2237
W D +KLEE M + ++ D + + D ++ + + M+ ++L+ + E L
Sbjct: 4347 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4402
Query: 2238 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2294
K+F+SE + + +E L+ + + L K + D ++ LM+ KL + +E
Sbjct: 4403 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4459
Query: 2295 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2349
+ L+ Q + ++++ W T E L + E L K +Q ++
Sbjct: 4460 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519
Query: 2350 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2408
+ QS + + + N L E +L + L ++ + V + + + L +L
Sbjct: 4520 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4579
Query: 2409 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
K F +++ Q+W + S G + + +L+ + + + ++
Sbjct: 4580 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4639
Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
Q+GQ + A K ++I + I E++++ + + K L++ + F + +
Sbjct: 4640 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4699
Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
W+ + E+ N + + + HKV F E+ + RE + +L + G L +
Sbjct: 4700 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4755
Query: 2588 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2643
Q+ L LL S Q+ +++ E+ RS A + + EA + W++
Sbjct: 4756 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4815
Query: 2644 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2702
+ L D ++ +L+Q ++ G + G ++S +
Sbjct: 4816 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4875
Query: 2703 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2762
+ L L++ W I SV Q+ LE + + + L W+ V+ ++
Sbjct: 4876 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4935
Query: 2763 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2821
+ L+D+ ++ E T ++ L +REL E +D S+ +EL T++
Sbjct: 4936 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4995
Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
+ ++ K ++E ++ + VH +WL A++ L + D A + +
Sbjct: 4996 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 5055
Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
+ KE + E + L++ ++ V + + +RA ++E+ + +
Sbjct: 5056 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 5112
Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
+ L S +A G +A+ ++ LE A L+ WA+ T L K D+E++
Sbjct: 5113 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 5155
Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
QEI E++K+ + E F +++ V + K Y
Sbjct: 5156 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5189
Score = 210 bits (535), Expect = 4e-53
Identities = 144/429 (33%), Positives = 219/429 (51%), Gaps = 65/429 (15%)
Query: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
R+ DE++ VQK+TFTKWIN HL K + V+DL+ED++DG L++LLEVLSG LP E+
Sbjct: 206 RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 263
Query: 80 GRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELT 139
GR R H + N+ AL +L+ R++KLVNI + DI DG P + LGL+WTIIL+FQI ++
Sbjct: 264 GRM--RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 321
Query: 140 SNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE 199
V+ E+ +AK+ LL W Q GI
Sbjct: 322 -------------------VTGESEDM------------SAKERLLLWTQQATEGYAGIR 350
Query: 200 VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPE 259
++F WR G F+++IH RP+L+D+ TV +SN NLE AF +AE ++G+ RLLDPE
Sbjct: 351 CENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPE 409
Query: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
DVDV PDEKS++TYV+ +P + +G +++ + + N V + R
Sbjct: 410 DVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYLIQWIRHH 468
Query: 320 FKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHLIQPLHRD 375
M ER + L ++Y FK + + K K++ L++
Sbjct: 469 VTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEF 522
Query: 376 GKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVH 435
G++ L Q ++ +W G + + E ALR E+ ++
Sbjct: 523 GRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPEVERLEML 564
Query: 436 EETANTIQR 444
++ AN +QR
Sbjct: 565 QQIANRVQR 573
Score = 162 bits (411), Expect = 1e-38
Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)
Query: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 1187 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1244
Query: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 1245 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1304
Query: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 1305 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1349
Query: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 1350 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1400
Query: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 1401 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1460
Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 1461 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1520
Query: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 1521 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1580
Query: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 1581 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1640
Query: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
EK + S QK S KE +T L +K +
Sbjct: 1641 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1700
Query: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 1701 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1760
Query: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 1761 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1814
Query: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 1815 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1874
Query: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
W+ ++ + H + T
Sbjct: 1875 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1934
Query: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 1935 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1994
Query: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 1995 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 2054
Query: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 2055 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 2114
Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 2115 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2173
Query: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 2174 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2230
Query: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 2231 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2290
Query: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 2291 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2350
Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 2351 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2405
Query: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 2406 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2464
Query: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 2465 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2522
Query: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
+ S+ NL + A A T+ E SI++ ++
Sbjct: 2523 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2582
Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 2583 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2642
Query: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 2643 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2702
Query: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 2703 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2762
Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 2763 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2822
Query: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 2823 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2878
Query: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
V E DLS ++ +A S EG + KD + +
Sbjct: 2879 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2933
Query: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
SA S Q +Q+ + A D++ + Q + I +K L +K + K L S
Sbjct: 2934 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2993
Query: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
+ ++ E+ L + + S + L +T W+ Q +E ++K++L+K
Sbjct: 2994 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 3048
Query: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
++ + ++W W+ + LE+ ++ D E I KLK LQK +D ++
Sbjct: 3049 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 3105
Query: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
+N + + + D + + D V L + L++ + + F E+S
Sbjct: 3106 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3165
Query: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
L E +D + SN +LQ K L +KH++ L QD+
Sbjct: 3166 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 3222
Query: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
+ +++GT + +V I L ++V LE KL + Q + S
Sbjct: 3223 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3279
Query: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
DELD+ V GR QK
Sbjct: 3280 AEFDDELDSMAPV----GRDAETLQK 3301
Score = 96.3 bits (238), Expect = 1e-18
Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)
Query: 6806 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 788 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 840
Query: 6863 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6922
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 841 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 892
Query: 6923 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 893 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 944
Query: 6983 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 7041
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 945 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 1002
Query: 7042 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7099
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 1003 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 1055
Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7154
+T + + +I + D +SH+ + I+ EA
Sbjct: 1056 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 1115
Query: 7155 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 1116 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 1175
Query: 7209 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7253
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 1176 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1235
Query: 7254 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7293
Q++ EDR ++ +D + V I + L K L
Sbjct: 1236 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1294
Query: 7294 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 1295 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1351
Query: 7354 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7407
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 1352 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1411
Query: 7408 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7456
+L + + + KE ++ L W + Q R L+ L
Sbjct: 1412 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1471
Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 1472 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1527
Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1528 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1572
Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
+ E L V + Q + D ++ E+
Sbjct: 1573 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1608
Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7692
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1609 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1662
Query: 7693 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7750
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1663 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1710
Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7806
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1711 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1762
Query: 7807 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7852
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1763 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1822
Query: 7853 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7905
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1823 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1882
Query: 7906 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7930
SE A K ++ S EE Q LN+Q
Sbjct: 1883 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1942
Query: 7931 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7985
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1943 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 2001
Query: 7986 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 2002 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 2060
Query: 8045 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8092
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 2061 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 2120
Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8146
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 2121 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2178
Query: 8147 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8204
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 2179 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2238
Query: 8205 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 8260
++KL ++ L R L ++D L W SL P S+ L
Sbjct: 2239 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2288
Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 8319
+++ + E+ +S+++ ++ ++ M PS Q KD R
Sbjct: 2289 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2338
Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
+ S H +++ +L ++ ++ + + +KT E+D K +L
Sbjct: 2339 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2397
Query: 8380 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
S LEHK E SL ++ H + A V+++ L + E +K+
Sbjct: 2398 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2455
Query: 8439 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 8475
++ F + S+ +W+ +T ++ LE ++L+ +
Sbjct: 2456 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2515
Query: 8476 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 8520
+T E+Q L L AV I ++ + + E T +++E +
Sbjct: 2516 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2575
Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
+ ++ ++ ++ + LL++ L L + Q E S ++ L+ +++ +
Sbjct: 2576 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2635
Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
+ D E ++ +Q + EL ++ +V L+D +LL E D EA
Sbjct: 2636 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2685
Query: 8641 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 8685
R K +L E+ +EL +L L+ SS+ + L W EL S +
Sbjct: 2686 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2744
Query: 8686 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 8745
P S PN T R + + + P LS PG S RG + L
Sbjct: 2745 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2802
Query: 8746 RA 8747
A
Sbjct: 2803 AA 2804
Score = 54.7 bits (130), Expect = 4e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 366 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 4778 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4826
Query: 425 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 4827 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4870
Query: 479 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4930
Query: 525 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 4931 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4985
Query: 585 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 4986 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 5045
Query: 639 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 5046 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 5105
Query: 692 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 5106 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5165
Query: 747 QD----LEDIEQRVPVMDAQYKIITKT 769
+ +E++ ++ P +D +TKT
Sbjct: 5166 AEHQTFMEEMTRKQPDVDK----VTKT 5188
Score = 33.9 bits (76), Expect = 7.3
Identities = 90/474 (18%), Positives = 181/474 (38%), Gaps = 61/474 (12%)
Query: 8169 QGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 8228
Q +QL+++ A + +E+ LR C V+ + + +L + L+ +
Sbjct: 636 QADQLVQR-----VAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ 690
Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
+ S L SL SS+++ L+ + S + TPA P
Sbjct: 691 TLHPSLTSGL------TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS----- 739
Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG--DHSALESQI-----RQLGKA 8341
L + S + E Q K +R + S D + E +I + L
Sbjct: 740 -GLVPNFSSGV------EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 792
Query: 8342 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
+D+ + Q+ +TE S P+ ++K + + E SS+ E K+ E + +
Sbjct: 793 VDEMQVQLDRTE--WGSDLPSVESHLENHKNVHRAIEEFESSLK-----EAKISEIQMTA 845
Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8461
P + A + R E A+ L+ +++L F S + WL + EE
Sbjct: 846 P-------LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 898
Query: 8462 ELEQLQRLELSTDIQTIELQIKKLK----ELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
E E++ D I + K EL + +D ++ I S+ + + +
Sbjct: 899 E-------EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPAR 951
Query: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHG--LLLMLENIDRRKNE 8575
++ + M +W + L + +++ + F++ L L++ +RK
Sbjct: 952 LTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK-- 1009
Query: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDC 8628
D + L+D ++ M+ K ELL+ + +A+L + ++ + +DC
Sbjct: 1010 -YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 1062
Score = 33.5 bits (75), Expect = 9.6
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 375 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4930
Query: 427 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 4931 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4989
Query: 484 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 4990 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 5049
Query: 536 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 5050 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 5093
Query: 592 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 5094 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 5136
Query: 652 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 5137 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5187
Query: 712 EY 713
Y
Sbjct: 5188 TY 5189
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 372 bits (955), Expect = e-102
Identities = 717/4026 (17%), Positives = 1587/4026 (39%), Gaps = 438/4026 (10%)
Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 1285 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1341
Query: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1400
Query: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
T +V +Y+ G S +R +SL E ++ E +K +
Sbjct: 1401 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1458
Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1453
+K+A + P +KQ K E++ ++ L E ++T+++ K D +
Sbjct: 1459 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1512
Query: 1454 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1506
E + E + L L+ S ++ D+++ + + QE + KL I L +
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1566
++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1573 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1629
Query: 1567 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1626
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1630 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1671
Query: 1627 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1673
A++++ E + +++ +E +T +ENLL ++K+ + T +
Sbjct: 1672 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1727
Query: 1674 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1713
G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1728 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1787
Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1788 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1845
Query: 1774 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1828
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 1846 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1905
Query: 1829 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
K+ + ++ A D F+ V+ L L + Q
Sbjct: 1906 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 1962
Query: 1877 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1930
+ S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++ +
Sbjct: 1963 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2021
Query: 1931 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1988
A+ L S + + T D + G E + + + + + QD +
Sbjct: 2022 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2081
Query: 1989 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
E+L + ++E ++ ALQ + LE ++ + + + +K K+ +
Sbjct: 2082 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2141
Query: 2049 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
D + A + ++ L + + E + L + ++NL + LE +
Sbjct: 2142 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2201
Query: 2108 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2162
+ T + KD +L Y Q+ F KHL S LK+I S
Sbjct: 2202 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2247
Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2216
+ +D ++K ++S+K +E D ++ + V S +++++ + +
Sbjct: 2248 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2301
Query: 2217 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2269
+ + + + + AE+L K E K + +L+ E+ KVN+ L L +
Sbjct: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2360
Query: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2328
TP AK I V G + + +T E+F + T +++ +
Sbjct: 2361 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2402
Query: 2329 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
+ + L +KD EL ++ S + QE +++ + + T
Sbjct: 2403 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2461
Query: 2389 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2448
EAV KTQ +S E +++ + QE L+ KL +
Sbjct: 2462 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2495
Query: 2449 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
L + + T A KQ+ +T+ + ++Q + + +Q
Sbjct: 2496 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2532
Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2533 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2590
Query: 2569 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2624
+ ++L+ GQ +LS G G + QL Q +T + C A+
Sbjct: 2591 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2650
Query: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2682
+ + L+S+ + + ++L+ + + D + ++L Q + + + + ++K+
Sbjct: 2651 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2710
Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2711 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2769
Query: 2743 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2793
+ W+++ +Q HP+ + LD L+S++ + +D ++ L +
Sbjct: 2770 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2820
Query: 2794 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y + V
Sbjct: 2821 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2879
Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
W+ Q L +IK +D E G + +++++SL E+ Q+
Sbjct: 2880 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2921
Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
EL++ +L + + ++ V L V + + + Q +
Sbjct: 2922 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2979
Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
+F + K +QL + + + + + L LQ + + LK Q++ R +
Sbjct: 2980 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3039
Query: 3031 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3071
+DL + G + +E++ L Q + C E LQ +
Sbjct: 3040 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3099
Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3131
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 3100 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3159
Query: 3132 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3191
L+ GI+ + A + +E +E ++++F + L K
Sbjct: 3160 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3213
Query: 3192 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3246
E+ HE S + + QQ + + EP L+ K Q + W GQ +A
Sbjct: 3214 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3267
Query: 3247 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 3268 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3327
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
++ + P+++ V+ ++ + + L + +++ +++I GE + P I +
Sbjct: 3328 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3387
Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
QL + W +LL+ QLEG + + + + W+ ++E L E +
Sbjct: 3388 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3447
Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3475
+ + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3448 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3507
Query: 3476 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3532
IQE++ ++ + + + D WL + +KL + SV + ++ L
Sbjct: 3508 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3567
Query: 3533 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
R LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3568 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3625
Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWHEE 3647
+ R + +++ WL E E +S T+ + Q+ ++KK +
Sbjct: 3626 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3685
Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
A D + EV + E++ +R G + + RY+ + + ++++ ++ I
Sbjct: 3686 NKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3742
Query: 3706 SLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
++ + + + W T K + + + D+ + +K T+E+L +
Sbjct: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKD 3797
Query: 3763 LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3822
++ + G + + E E + ++K++ ++ + + ++ LE+ L +F
Sbjct: 3798 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3857
Query: 3823 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
+ + L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G
Sbjct: 3858 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3917
Query: 3883 LLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
LLEL + ++++K + Y + K+ +L+ + ++ ++ ++ + L +
Sbjct: 3918 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 3977
Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC------ 3994
+ RL P + ++ +E I +Q++ +K + ++ + L+ +G+ +I +
Sbjct: 3978 IVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4036
Query: 3995 --ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
A +Q KL Q N+H ++ + + A++ + H+S T++
Sbjct: 4037 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIK 4089
Query: 4047 QCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLS 4100
Q ++ ++ P ++PS + AE I++ LQE+ ++L L + C +
Sbjct: 4090 DTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPD 4147
Query: 4101 NASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4156
VK + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 4148 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4207
Query: 4157 KRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHL 4214
++LE + + ++K F + +Q + + + L KK EES +H + L
Sbjct: 4208 SPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 4265
Query: 4215 NDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4271
+ W L + N + E L + ++ + +L +
Sbjct: 4266 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 4325
Query: 4272 AVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE 4329
A+ +E K L + + +E + +IE ++ ++ + L QRW +
Sbjct: 4326 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4385
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ +++ Q L + ++L +W + + ++ + P+ A+ L H+
Sbjct: 4386 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4445
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+C+ EAK+ KSL++ +++A + I + +++ + + + +R+ L
Sbjct: 4446 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4505
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4509
+AL+ +F ++ + + Q E+ + L+ D V Q+ K + +++ +
Sbjct: 4506 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4565
Query: 4510 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4569
+ L G L +Q+ + L +QS ++ V+Q+ R + L+ K F E
Sbjct: 4566 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4625
Query: 4570 DFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTI 4629
+ K WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4626 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685
Query: 4630 LPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L
Sbjct: 4686 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4745
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTG 4744
+E Q V D ++ ++L D +A E+ +V L + EG R
Sbjct: 4746 RVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4803
Query: 4745 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
W +M L T + + + + + LE +E + L L + EQ+
Sbjct: 4804 S-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLR 4860
Query: 4805 NEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4859
LP +E + + L++ L + T + + P + +H I
Sbjct: 4861 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4920
Query: 4860 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4919
+ + + + + S + I Q + L WL+ + L+ D + +
Sbjct: 4921 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEV 4975
Query: 4920 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
I +EI +++ E Q+ + M + +K TK + +AD + + LD
Sbjct: 4976 IPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG 5034
Query: 4980 ALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLA 5019
R ++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 5035 RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFA 5094
Query: 5020 GNGLDV 5025
D+
Sbjct: 5095 NFDFDI 5100
Score = 340 bits (873), Expect = 3e-92
Identities = 720/4013 (17%), Positives = 1591/4013 (39%), Gaps = 492/4013 (12%)
Query: 442 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 1112 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1169
Query: 502 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
K++ + L +L AE+ +K + K E+V + ++N +S + E
Sbjct: 1170 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1226
Query: 551 KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
+ F E ++ ++ K E + D E+A+ +++ +W+N+ V++
Sbjct: 1227 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 1279
Query: 603 SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
+ LE + + Y +T L W++ E NQ EN+K + N +
Sbjct: 1280 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1339
Query: 657 HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
M + + E S +K L +++ + + VK+ D +
Sbjct: 1340 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1396
Query: 710 KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
+E+ D +A T +++ ++ + ++K L ++ + +E+ + K + K
Sbjct: 1397 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1452
Query: 770 AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
I+K + ++ GK F+ E+++ KE S L Q L
Sbjct: 1453 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1512
Query: 819 ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
ELEKQ+ + +S + +E+Q+S K + + + Q+ K+ L
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
Query: 871 ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
+I G+ ++K+ + L+ D + +A++ ++ +K+ G+
Sbjct: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1631
Query: 919 -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
K +E +L K E+S+ EL+KV+ A +E E+ ++L T
Sbjct: 1632 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1691
Query: 965 EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
+ + LD +L D+ ++ + +Q +++ H Q D + E +
Sbjct: 1692 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1743
Query: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
LL +D + + + +E + ++ K EKII +H+ V + + L EK+
Sbjct: 1744 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1795
Query: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
Q + EE K ++ +++ L E + T+ L E+ +K+ DYT
Sbjct: 1796 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 1847
Query: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
EF W+ +E +L+ ++ A D ++KR + ++ +G+ S +VL
Sbjct: 1848 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1907
Query: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
S + + + KL + +L S+ + +N D V + +++
Sbjct: 1908 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1967
Query: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
L++G + + A K L +E + + L ++TK + + Q + + ++
Sbjct: 1968 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2026
Query: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
L D L ++ TLD L +S + ++Q+TL + + + ++ +
Sbjct: 2027 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2086
Query: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
+ SS + L+ ++L+ +S + ++ + R SI E VK+ E P
Sbjct: 2087 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 2144
Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
LQ + K + + + +E + ME +KTK + F + E L ++ K + L
Sbjct: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204
Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
++ + ++ + E + L + + + A + K +
Sbjct: 2205 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 2264
Query: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
+ +E+ + + + + Q F+ ++ ++ + E
Sbjct: 2265 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 2324
Query: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
ED + K E KV + LC + ++++ A +A S V+N +
Sbjct: 2325 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2384
Query: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
S ++ + YED+ K++ L L+ Q+ ++E S+ + WL+
Sbjct: 2385 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2444
Query: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
+ A+ + D A + +VE L+ V KL +L E
Sbjct: 2445 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2504
Query: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLF 1784
K M L ++D +W++L Q+ R L+ QF + W+ +L
Sbjct: 2505 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2561
Query: 1785 LSELQTTS-----------EISIMDHQVALTRHKDH------AAEVESKKGELQSLQGHL 1827
+S L S ++ I+ + A TR + + S+ GE SL+G +
Sbjct: 2562 VSVLGPLSIDPNMLNTQRQQVQILLQEFA-TRKPQYEQLTAAGQGILSRPGEDPSLRG-I 2619
Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA---------------- 1871
K + L G+ D ++A + Q L L+
Sbjct: 2620 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2679
Query: 1872 --------EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAA 1923
+ L++ + ++Q ++ ++ ++ ++ S L++++ A + ++ LE
Sbjct: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGIL 2738
Query: 1924 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD-------AL 1976
S + KA+ H+ + S A++ Q Q L TK+ E + L
Sbjct: 2739 KSFKDVEQKAENHV-----QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2793
Query: 1977 AVLKKAFQDQKE--ELLKSIEDIEERTDKE------RLKEPTRQALQQRLRVFNQLEDEL 2028
VL+ +D K+ + L + + E+T E + + + ALQ +L D
Sbjct: 2794 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2853
Query: 2029 N----SHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE---VTWDDTK--------RL 2073
N E++L +KA + ++ P +D+ N LE D + +
Sbjct: 2854 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2913
Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSK-----VLENASSVIVTRTTIKDQ--------ED 2120
+ + Q G+++L+ N +V + V + S+I + +Q E+
Sbjct: 2914 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 2973
Query: 2121 LKWAFSKHE----TAKNKMNYKQKDLDNFTSKGKHLLS---------------------E 2155
+ F + + +K ++ ++ LD S G S +
Sbjct: 2974 MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3033
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
L K + D + +D + T D L V E + + L + L T+ + G N
Sbjct: 3034 LAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQN 3092
Query: 2216 CVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2268
+ +M + D+ L R E L++ + +K +LE L + ++ + K +
Sbjct: 3093 TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM 3152
Query: 2269 ----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
ET PDL I+ DL + ++ + A+ A+ QVE I + +++K++
Sbjct: 3153 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTIKRLEEFYSKLK 3205
Query: 2325 E---SLMNCAQNETCEA------------LKKVKDIQKE----LQSQQSNISSTQENLNS 2365
E L ++E + L K QKE LQ +Q +++ + L
Sbjct: 3206 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQ 3265
Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFL 2423
K S + L + + + + +++ ++ A LQE+L F ++++ W +
Sbjct: 3266 SAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3323
Query: 2424 GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2483
+ + + KV++A++ + + + + D +S ++ + +EG+ +
Sbjct: 3324 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
Query: 2484 SIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTEN 2542
I +Q++ + ++A L + + L+ + F + LN W+ +E+R N E
Sbjct: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
Query: 2543 LGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
+G + E+ ++++ L + ++ +SL LS R E Q
Sbjct: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR------EDKDMVQSK 3497
Query: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
SQ+ + + + + Q AL + E + W+ + D+L+
Sbjct: 3498 LDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDY 3555
Query: 2656 SKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLK 2711
S + L K+ S++ +DILL K ++ A+ G + L+ + + +IQ +LE +K
Sbjct: 3556 STEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3611
Query: 2712 EVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI----------EHPLQ 2761
+ DI S TLE + +L W++ V+ ++ E Q
Sbjct: 3612 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3671
Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESFKDTAQEELKTQ 2820
Q KE + +++L + + AL L+ ++RE EK E +
Sbjct: 3672 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED---------NER 3722
Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
+ + +K+ +++ + + A W+ +++L D+ + T +L
Sbjct: 3723 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3782
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
K + EI + ++ + SG ++M + + K+ D V +
Sbjct: 3783 QVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831
Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD-EEIVECW 2999
+ + S+ L + V Q + E+ L ++ L + E + +
Sbjct: 3832 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3891
Query: 3000 HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY---NCLCLQASK 3056
+ +++ + + + +P + + +L S G+ + ++Y + L Q +
Sbjct: 3892 EEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLYSQIKE 3945
Query: 3057 GCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3116
+ + L + ++ F + + + + + +S ++KI+E +SE++N
Sbjct: 3946 DVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4004
Query: 3117 GQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDWKNFHSNLHQKE 3165
+ + E L ++ + AK +Q K+ W+N H+ + ++E
Sbjct: 4005 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
Query: 3166 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHC 3225
+ L ++ + F + + T+ + + + D +++Q+ +++ EEI
Sbjct: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDG 4124
Query: 3226 YEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3283
+ +L+ + +L G+ + + +L+S + +L+ K+++ +L+ +
Sbjct: 4125 LQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAV 4184
Query: 3284 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
Q+ G++ + DW+ A L S +D + + +L+ S +++I+M+ + +
Sbjct: 4185 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4244
Query: 3344 GESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E +L+ + E T+Q L +K +W SL I + +LEGAL +Q + +
Sbjct: 4245 AELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4304
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYV- 3461
W+ E L+E + + + L K +L +VL++ S +E + G + E
Sbjct: 4305 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4364
Query: 3462 -----TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD 3516
Q +L+ L +R++ + E+ ++ + + +R + + +++ + WL + L
Sbjct: 4365 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4424
Query: 3517 QYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALE 3573
L G T + L E+ + S++ + ++ AE D+ +
Sbjct: 4425 ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN 4484
Query: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
+L++ W++ + +L+E +T+ +N Q WL AE+ ++ +R T
Sbjct: 4485 NLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT 4544
Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLL 3691
Q+ + K + EV ++R+++ E+ + S + + + SR++ ++
Sbjct: 4545 VLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQ 4604
Query: 3692 QVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLK 3748
+++E+ + L++ + ++ + S +W + K+ + +A DK+ T +L
Sbjct: 4605 RLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKT-----QLA 4659
Query: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV---- 3804
+ K + HS+ + G R++K + L+ + D + +L++ T+
Sbjct: 4660 QHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSELRDKWDTICGKS 4716
Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
+ LE+ L + +F+D +AL W+ + L + ++ + +K+ Q+
Sbjct: 4717 VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQK 4776
Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
+ SV++++ L+E +D + +K ++ +L + ++ +C++ LEA ++
Sbjct: 4777 ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4836
Query: 3923 DHEDYNSELQEVEKWLLQMSGRL----VAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
E+++S + + +WL + L V PD + +L T+ Q HK M+++
Sbjct: 4837 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPD--DEDALRTLIDQ---HKEFMKKLEEKRA 4891
Query: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
LN GDT++ C +K + + + + + A++ Q L L
Sbjct: 4892 ELNKATTMGDTVLAICHPDSITTIKHWITI----IRARFEEVLAWAKQHQQRLASALAGL 4947
Query: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4091
+++Q+ L+ AWL + L + + ++++ +AL + +T+++
Sbjct: 4948 IAKQELLEALLAWLQWAETTLTDKDKEVIP-----QEIEEVKALIAEHQTFME 4995
Score = 320 bits (819), Expect = 5e-86
Identities = 790/4278 (18%), Positives = 1616/4278 (37%), Gaps = 541/4278 (12%)
Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1337
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 1005 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1064
Query: 1338 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1387
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 1065 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1121
Query: 1388 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1447
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 1122 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1180
Query: 1448 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1507
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 1181 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1236
Query: 1508 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1540
Q S F T E +I +L + G+ L+ +
Sbjct: 1237 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1296
Query: 1541 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 1297 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1349
Query: 1598 LCQAL-ESLSSAITAFS-----------ASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1645
CQ E S+ + + + + V R A + Q++ D+ +
Sbjct: 1350 ECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL----RT 1405
Query: 1646 RQTALENLLAHW--------QRLEKELSSFLTWLERGEAKASSPEMDIS-ADRVKVEGEL 1696
R TAL L+ + +RLE+E S + KA + +S + + E
Sbjct: 1406 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1465
Query: 1697 QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKR 1756
+ +S +K QL E+L ++ +L L + ++ D +
Sbjct: 1466 AGKPPFSKQKISSEEISTKKEQLSEALQTI---------QLFLAKHGDKMTD------EE 1510
Query: 1757 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESK 1816
N L+ V Q+ LL S S+ L E QT+ ++ + + ++ R +++ +++
Sbjct: 1511 RNELEKQVKTLQESYNLLFSESL---KQLQESQTSGDVKV-EEKIVAERQQEYKEKLQGI 1566
Query: 1817 KGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
L + L +G E + G E +++ Q L + +Q
Sbjct: 1567 CDLLTQTENRL-----IGHQEAFMIGDGTVE------------LKKYQSKQEELQKDMQG 1609
Query: 1877 HA-SLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKAL----ESAAVSLDGIL 1930
A +L+ +++ + E +++ + LIE+ LN+A + L E + LD ++
Sbjct: 1610 SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1669
Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL------------------------ 1966
+ A ++ T A QL +I+NLL
Sbjct: 1670 TTA--------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1721
Query: 1967 GTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2023
GT E D K A ++ E LL++ D + T +E L + ++ Q ++ +Q
Sbjct: 1722 GTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1777
Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT-------KRLIHE 2076
+ + + + L+ + + ++ ++ ++ + + L+V ++ +L H
Sbjct: 1778 HQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTHS 1834
Query: 2077 NQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
Q + E+++ + LEN A + T +K Q+ H+
Sbjct: 1835 LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG-- 1892
Query: 2133 NKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRL 2192
DL T G +L K D V T +V KL+ DR
Sbjct: 1893 --------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHR-----EVQRKLDHATDRF 1939
Query: 2193 RVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISNLDNHL------------RA 2233
R S + D++ E S + + + HL R
Sbjct: 1940 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1999
Query: 2234 EELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEIT 2292
E K + ++ ++ + +E+L L + +L D+Q D++ + E +
Sbjct: 2000 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2059
Query: 2293 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ---NETC--EALKKVKDIQK 2347
L+ +S V+ ++++ W VE SL Q N T + + K +++
Sbjct: 2060 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2119
Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
++ +QS+I++ E + + SL M L + S +T A ++E
Sbjct: 2120 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2179
Query: 2408 EK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
K E++ E + FL K A D G V E + +Q + + L+ +
Sbjct: 2180 TKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY-MQESTSEFLEHKKHLEVL 2237
Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
+ + +H + + E+ +++F+ + K+A+ C +L +F+ +
Sbjct: 2238 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297
Query: 2527 LNLWIHEMEER-------FNTENLGESKQHIPE-------KKNEVHKVE---MFLGELLA 2569
L WI E ++ F E+LG+S + + K E+ KV + L L++
Sbjct: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
Query: 2570 A----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-----------HQNLLRMTKE 2614
A +++ + G +L+ EG E ++ LTS +++L + K+
Sbjct: 2358 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2417
Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
K+ L + + +E +M W++ + + T DT + Q+
Sbjct: 2418 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQN---KS 2474
Query: 2675 GEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLETLKEVWADIMSSSVHAQSTL 2728
E E+K N+ + + + L +E + L + W ++ ++ Q L
Sbjct: 2475 FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL 2534
Query: 2729 ESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDH 2786
E + + + QL+QW+ + + PL P + +Q +L E
Sbjct: 2535 EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN--TQRQQVQILLQEFATR 2592
Query: 2787 TRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDIMT-VAKEKMRKVEEIVKDH 2842
+L A + + + ED S + +E+L TQ D +T ++ +++ +
Sbjct: 2593 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2652
Query: 2843 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELI--DSREIGASRL 2897
Y + +D L +L +S A ++L K+K+ I + ++I ++
Sbjct: 2653 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQ- 2711
Query: 2898 SRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2956
+ E L+ VK+ E + E+ + L K ++D + ++ +++L S A S Q
Sbjct: 2712 ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2764
Query: 2957 EFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLEGKNTDEEIVECWHKGQEIL 3006
+Q F A L T ++ L +LE D + Q +
Sbjct: 2765 --------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2816
Query: 3007 DALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
AE LK+Q +E L+T K+ + +E L+
Sbjct: 2817 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV-----------KERENKLK 2865
Query: 3067 QRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNISEVST--SLQK-IQEFLSES 3114
+ KA + +Q W+ + + C D + + ++ SLQK + +
Sbjct: 2866 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2925
Query: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
E + N +LS E+ ++T E IQ KV E LH K+ LEN+ +
Sbjct: 2926 ELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-------LHSKKFCLENMTQK 2977
Query: 3175 MKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNR 3232
K+F EVS E + E++ +H+S L + LQ+ + + + Q++
Sbjct: 2978 FKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3034
Query: 3233 LKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3289
K AQ L + SK +V ++ ++ LS EK S L+ + F I
Sbjct: 3035 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3094
Query: 3290 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKLEALLSVKQEKEIQMKMIVT 3342
+E+ + LDS D L + KLEAL++ KM++
Sbjct: 3095 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3154
Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E TSP+ + I++ L+++ LL + Q+EG + + + +++FS
Sbjct: 3155 TEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3208
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSYSSLLETIEVKGAGM----- 3456
+ E + E L K+ EE+ + + G G+
Sbjct: 3209 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3268
Query: 3457 --TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK 3514
T + +L D+ R++ + ++ + + ++ + +Q L++ W+ +E
Sbjct: 3269 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
Query: 3515 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3574
+ + + +++ + LQ + ++ + + E + + P + + L+
Sbjct: 3329 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3388
Query: 3575 LR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNR 3631
L W+A ++ Q + + + + ++EWL T E+++ +
Sbjct: 3389 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3448
Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------DESHVNSRMG------CQA 3679
+ E Q+ Q K +++ + + + + Q + D+ V S++ +
Sbjct: 3449 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3508
Query: 3680 TQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
+ + LL Q L K F E+E++ + +W H ++ +
Sbjct: 3509 QEKSHSRSELLQQALCNAKIFGEDEVELM-----------NWLNEVHDKLSKLS--VQDY 3555
Query: 3739 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3798
T + K+ L VL +D+ + A G +K E ++ ++ + K
Sbjct: 3556 STEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3615
Query: 3799 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3858
++T TLE+ L LA+ + L W+ + + L E ++ E +
Sbjct: 3616 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3675
Query: 3859 YKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKIDQLQSDYQDLCSIGKEHVF 3915
K L++ +++ + S+ E ALLELV L+ + + Y+ + + V
Sbjct: 3676 PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3735
Query: 3916 SLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAG 3975
++A + + ++ W+ + +L++ + +T + QL K EI
Sbjct: 3736 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3794
Query: 3976 FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL 4035
+D +++L G ++ C++ + +K+ + L+ +Y IC Y LE
Sbjct: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----NYDTICQINSERYLQLERAQ 3850
Query: 4036 QKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS 4095
+T ++ WL+ Q + P P L + + R QE+ R +L+
Sbjct: 3851 SLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EYETLRQQQEEHRQLRELIAE 3903
Query: 4096 MCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--- 4149
+ KT + ++ + +I++K V A L + +IK + + L +A
Sbjct: 3904 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YSQIKEDVKKRAVALDEAISQ 3960
Query: 4150 --------DQQLQNMKRRHSEL--------ELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
DQ L++++R L E+ + +S+ K+ ++ Q T+
Sbjct: 3961 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 4020
Query: 4194 EKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCLQREE---DLQRTRDYHDCM 4246
++ ++ + + K + DQ + + + L +RE D+ + C
Sbjct: 4021 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 4080
Query: 4247 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ------ 4300
++ + K T ++ D E + +K+ A + + I+ L+++
Sbjct: 4081 HMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4136
Query: 4301 -KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4359
++I DK +VK+ L W L K +I ++ Q Q + +W
Sbjct: 4137 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4196
Query: 4360 AEEQQPNIA----------------EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4403
+ +A E LKQ Q + M+ L +EL LLK
Sbjct: 4197 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL-----LLKK 4251
Query: 4404 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4463
+ +++D+ +Q L + + + L + + R+ L AL QF A+
Sbjct: 4252 VTEESDK----------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4301
Query: 4464 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE 4523
+ + + E + ++ + P + ++ Q + +Q+ V + G +L++
Sbjct: 4302 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4361
Query: 4524 VTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI 4583
+E S + KL+ L + +VL+K R Q+L+ L K F + + WL +
Sbjct: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421
Query: 4584 VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSE 4643
L QL + + E +L + GQ +L + + + +
Sbjct: 4422 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4481
Query: 4644 KLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD 4703
+N L ++ + ++ K++EA+ E+ + ++ L++ E Q L ++ P+
Sbjct: 4482 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE-QTLNVASRPS- 4539
Query: 4704 LAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ----PDKMLHLVTLY 4759
L ++ L D + +EV E + EL++ + Q + ++ + + +
Sbjct: 4540 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
Query: 4760 HRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 4811
++ ++ +R L+D A Q HE K+ + LE KS+ E N+ +T A
Sbjct: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659
Query: 4812 EEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK 4866
+ K L HS+ + +G LK T +D K + + +
Sbjct: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---------KLDDMLSELRDKWD 4710
Query: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG--PVYLDLNLQDIQEEI 4924
+ E + E ++ S F + +DWL RV+ +L+ PV+ D++L + I
Sbjct: 4711 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL--VMNLI 4768
Query: 4925 RKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4984
+ Q+E+ + AL +E +++ S+ ++ + ELS + ++
Sbjct: 4769 DNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKVQMQELSTRWETVCALSISK 4827
Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL-KSHMEFFSTED 5043
Q L Q + ++ V A +WL +A++ L+ G D E A L H EF +
Sbjct: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887
Query: 5044 QFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQKVASLELRSQRMSRDSG-- 5090
+ + L + ++ T+ + P + E+ +A + QR++
Sbjct: 4888 EKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL 4947
Query: 5091 -AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEK 5141
A+ +LL+ A QW + K +E + + + + + ++E F T + ++
Sbjct: 4948 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5007
Query: 5142 LSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGNDASKATLSRSMTTVWQRWT 5193
+K + +S I L++ AS L +G+ T + + + +W
Sbjct: 5008 TKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQ 5067
Query: 5194 RLRAVAQDQEKILEDAVD 5211
++ +A ++ + L DA+D
Sbjct: 5068 QVWLLALERRRKLNDALD 5085
Score = 318 bits (815), Expect = 1e-85
Identities = 900/4830 (18%), Positives = 1875/4830 (38%), Gaps = 684/4830 (14%)
Query: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
V+ W+D M+ L+ +E ++L + L K ++ + + S L+ ++ MT
Sbjct: 608 VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666
Query: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
L+L ++ +R + AK T + L LH R +WL +++E+
Sbjct: 667 ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 721
Query: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
Y E + + H +R+L + + + Q + +L P+ +
Sbjct: 722 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 778
Query: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
RA + W Q + + E F ++ ++L+ ++ +
Sbjct: 779 YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 830
Query: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
+ R S+ E + + + EE+ Y+ + + +A+ I+ NS + +
Sbjct: 831 KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 890
Query: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
+ Y+ + + + + + + + ++ S +E+ + S +K +
Sbjct: 891 PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 950
Query: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
+A +I++ + + TL + +K + H L+ R ++K + GE
Sbjct: 951 LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 1005
Query: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
++ L+ D +E +E + LEK +++ K++ YQE+L
Sbjct: 1006 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 1052
Query: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
E + E +S+ ++++ + + E ++ +R + E++ + + L
Sbjct: 1053 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1112
Query: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
K ++++L+ D + + +E FS A SEL V + + Q MS + D
Sbjct: 1113 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 1169
Query: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
L+T +L Q A + + EE A D+ NN++ TL Q + K +
Sbjct: 1170 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 1226
Query: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
Q HA L+ AI + Y+ + + H + D L + W + VQ D
Sbjct: 1227 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 1281
Query: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
L E I K +K++R ++ V+TT + IQ+ + +T
Sbjct: 1282 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1326
Query: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
+ +L Q + L EI+ +S++ + A+Q +K EL+ + MV +
Sbjct: 1327 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1381
Query: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
K + Q+S + II++ L + + + L Q++ S + E+ L+
Sbjct: 1382 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1436
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
+ H V K +W S+ T E K + Q K + E++
Sbjct: 1437 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1483
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
+K+++ E L L K ++ +LE +K T E N++ F E +
Sbjct: 1484 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1533
Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
+ +E Q + +++ + Q IC L + LI + M G
Sbjct: 1534 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1590
Query: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
E + Q +++ L K + Q L V + T + + +
Sbjct: 1591 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1632
Query: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
+E L+ +++ C+ Q +LK Q++ +EL K VT E EK
Sbjct: 1633 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1682
Query: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
+ +L+E ++ +++L K S R K ++ + HF+E + D+
Sbjct: 1683 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1742
Query: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
L + D+ N + + A+++ I+ Q ++ + L++ GQ + P
Sbjct: 1743 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1802
Query: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
E L + + L + +A ++ K + +QE + E+ ++ + Q
Sbjct: 1803 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1858
Query: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
L LEA ++ + T L E+ +S + R I + EA +++ G
Sbjct: 1859 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1918
Query: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
T + K+ H + L + + L+D YQ +E L L++ +
Sbjct: 1919 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1978
Query: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
SK E + + K L+ +L G + + LK+ L D L P A
Sbjct: 1979 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 2037
Query: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
+ + G + L+ ++ E + + + +S+ Q + LDW+ V++ L
Sbjct: 2038 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2097
Query: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
+ LN +Q+ I K + ++++ +NA++ K K+ ++ L+ + +L
Sbjct: 2098 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2157
Query: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
S + + A + E+ ++ + + + + +LE Q L ++ G DV
Sbjct: 2158 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 2215
Query: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
L +M+ ++E H +LE LHSL+ + P+ K + +K +L + + M
Sbjct: 2216 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2273
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
+ + + C Q +Q + + + +T KK+ F S E +KL E
Sbjct: 2274 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2333
Query: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
+L +S V + + I A++ + L E T + + ++
Sbjct: 2334 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2393
Query: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
+T++ + T + +D +L+D + E +K++KA E M+ LQ
Sbjct: 2394 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2453
Query: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
+ P + +A K T +E + +F EL+Q + + L+ + +L++ P E P
Sbjct: 2454 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2507
Query: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
Q +T + + + + + +++ + +T +K W+ E + LG
Sbjct: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567
Query: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
+I+ ++ Q +++QILL E + E++ + G+ + + SL Q
Sbjct: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2623
Query: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
LA V + Q+ D+ ++Q+ S Q Q L + L+ L+ L K + +
Sbjct: 2624 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2679
Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
T + ++L+ E+ ++ L + L L++++ + +
Sbjct: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2739
Query: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
+ ++AEN + L A + ++ +M W++ K N + + +
Sbjct: 2740 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2793
Query: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
+ ++L+++ K+ L A + + + E + + G E L+ + N
Sbjct: 2794 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 2849
Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
K +K+ E +LK+ +LE+A L KEQ+ + L ++ + +
Sbjct: 2850 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 2892
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
+ ++ C E+ +A L LQ+E QH + + +++ +
Sbjct: 2893 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 2943
Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
E E K L Q ++ ++ K N+ QE+ + R + A++ +
Sbjct: 2944 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3003
Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
+ S K LTM L + LA+ GT D+ ++
Sbjct: 3004 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3063
Query: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
H ++ +C L + + + T E+ S A S +PV ++ +
Sbjct: 3064 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3123
Query: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
A+ + L A D A + E P L L L + L +
Sbjct: 3124 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 3182
Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
++ + ++R +++ L+ S I L+ +E E + P E++ Q M
Sbjct: 3183 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 3237
Query: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
++ ++EI LQ L + L+ + ++ + L+ L + R T+ K
Sbjct: 3238 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 3294
Query: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
+ + L+E L L R + AL+ L SW++ T+ + P E ++A
Sbjct: 3295 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3344
Query: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
Q L+D + VE+ KV L +LS+ + L KA
Sbjct: 3345 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3404
Query: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
T++ R+L+G + Q+ H+ + LN T EK + + TQ+ ++E
Sbjct: 3405 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3454
Query: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
+AQ + + K L Q ++ +SL + ++SR ++ ++Q E
Sbjct: 3455 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3509
Query: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
+ + ++L Q L K ED++ M W +H Q++ST+ Q + L
Sbjct: 3510 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3567
Query: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
QE +L + N LL+G+ L K + + L+ + +++++ S +
Sbjct: 3568 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
Query: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
Q++ L ++L+ TWLD VE L + L EE + L K+ K
Sbjct: 3627 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3686
Query: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
+D + N S A E G + V ED R L+ + Q+ ++
Sbjct: 3687 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3740
Query: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
+ + + F+Q ++ I + E L +E
Sbjct: 3741 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3774
Query: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
+ +LQV++ E+ + +D+ D+L+ + ++ ++K + ++ L++
Sbjct: 3775 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3834
Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
+ + E+ E Q L+++ E ++ L LTET + IIS
Sbjct: 3835 ICQINSERYL--------QLERAQSLVNQFWETYEELWPW--LTET--QSIIS------- 3875
Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
+L A A LEY ET QQE RQL L+ E
Sbjct: 3876 ----QLPAPA-------------LEY--ETL----RQQQEEHRQLRE---------LIAE 3903
Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
++ + +N+ P+L + L G+ I ++ +Q+ E
Sbjct: 3904 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 3945
Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
+ K L+ + T++ + ++ L+ +RL +Q ++ E+E +++ ++
Sbjct: 3946 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 4000
Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
S +++ L ++ G +++ K + ++ +L ++ W ++ T +
Sbjct: 4001 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4060
Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
+ KL L + +L + MS I +++ D I + + + +
Sbjct: 4061 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4117
Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
+ +I+ Q +D V + + S+ + + DK + + +N +W L ++I
Sbjct: 4118 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4173
Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
LE +++ +Y++ +Q + W + +L IG D +V+ +++ + +
Sbjct: 4174 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4233
Query: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
++ E+E++ L++ E+ V L EL W +L+ + + L+ L
Sbjct: 4234 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4293
Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
+ A D++ ++L LS + + G +A+++++ LQ+D+ + +++
Sbjct: 4294 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4353
Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
N L++ L N L+ +N RW N+LE+ ++ Q L+ + K + +
Sbjct: 4354 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4410
Query: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
Q D LL + + A +++ ++ C T K L + G+Q
Sbjct: 4411 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4466
Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
+ + SA + I D +L + ++E L +++T L+ + F SL+ W+
Sbjct: 4467 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4526
Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
+AE+ L S L T+ +++E K + +S + L++ G L +++
Sbjct: 4527 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4585
Query: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
++NL W + + ER L + + F E ME+L ++E+ L +
Sbjct: 4586 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4645
Query: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
EI+ + + Q H+ FQ + ++ + + G+ L E+ + DD + + L+ L
Sbjct: 4646 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4705
Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
++W + ++ +R+ ++ + ++ + + L WL V ++ V +
Sbjct: 4706 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4764
Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
L D K F ++ G +V+A K+ L+ + ++ ++ E+ +W++
Sbjct: 4765 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4820
Query: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
++ +L L+ E+ + LE L ++ L LPD + L + K
Sbjct: 4821 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4880
Query: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
E + +L + + + DT+ A D I+ + + +++ ++EE+ +Q++
Sbjct: 4881 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4940
Query: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
L E + L WL E+ ++ +I + IE++K + + EE+
Sbjct: 4941 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5000
Query: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
Q + ++ + +R A SH ++IE K +VN
Sbjct: 5001 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5060
Query: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
+WQ + L R +KL + L +++L
Sbjct: 5061 LLVSKWQQVWLLALERRRKLNDALDRLEEL 5090
Score = 298 bits (763), Expect = 2e-79
Identities = 728/4019 (18%), Positives = 1555/4019 (38%), Gaps = 470/4019 (11%)
Query: 4948 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 1108 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1167
Query: 4999 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 5043
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 1168 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1227
Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5097
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 1228 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1287
Query: 5098 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5155
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 1288 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1344
Query: 5156 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5213
K+ ++ A Q T D T++ R+M Q+ + R + + I+++ +D
Sbjct: 1345 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1404
Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
T + V T+ I D L E+ S E + H EL++ S +
Sbjct: 1405 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1457
Query: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5327
+TL + P ++ +EI+ +++ + + K K+ +E + E
Sbjct: 1458 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1517
Query: 5328 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5387
V+T S E+ + L D ++EE + + + +E KEK G
Sbjct: 1518 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1565
Query: 5388 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5430
+ +L + + + + ++LK Q+++++ Q A T L
Sbjct: 1566 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1625
Query: 5431 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
+KL+++ + L + K K + + ++A+ +K L + + + E AAV++
Sbjct: 1626 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1685
Query: 5486 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5539
E ++ L + K +E H+Q I Q + S + E +E+ +
Sbjct: 1686 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1744
Query: 5540 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5596
L+ +V GT N Q ++ H+ ++ + + + + + EK S
Sbjct: 1745 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1801
Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
EK+ + + EL E + +++ ++++KF+A+ + + L+Q++ L
Sbjct: 1802 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1861
Query: 5657 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5705
+ E G LK Q S + ++S L+ + ++ +S + V +
Sbjct: 1862 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1921
Query: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5761
R + A+ + +CN++ + V +Y+ YE L
Sbjct: 1922 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 1970
Query: 5762 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5819
+ +Q +A S+H E +A K Q Q+ + ++ + ++ + V
Sbjct: 1971 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2018
Query: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5867
+++ AE D G LLP + + GR L V E S ++
Sbjct: 2019 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2078
Query: 5868 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5919
G N E S + P ++++I Q ++ + +A ++
Sbjct: 2079 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2136
Query: 5920 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5979
E +P S AK+ DL + + E + E + + +++ + + T +
Sbjct: 2137 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2196
Query: 5980 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 6039
E L+E PG+ Q E L + + E+ SL +E+ S +D A
Sbjct: 2197 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2255
Query: 6040 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6089
L + L+ + M TI+ K Q+L + L ++E ++ + +
Sbjct: 2256 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2315
Query: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
A++L L TK + E + + N++ + A++ +V +
Sbjct: 2316 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2373
Query: 6150 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6206
+L G+ + E A K L +K + ++ D L ++ E S +
Sbjct: 2374 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2433
Query: 6207 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6255
+S + +WL + T T+ +Q+ ++Q K E EL + + ++ + +
Sbjct: 2434 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2493
Query: 6256 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6299
E+L E + D E P D QEL + E+SS
Sbjct: 2494 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2547
Query: 6300 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6337
E+ +++ +++L+ +VL +++Q Q+L Y + G+
Sbjct: 2548 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2607
Query: 6338 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6394
G+ P+ + V L + Q ++ ++ Q Q+I + + + S L
Sbjct: 2608 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2666
Query: 6395 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6454
D++ +L + A+ T NQ++ + + +K + +QA E+ V
Sbjct: 2667 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2722
Query: 6455 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
E+ L L R +L S V Q+ + LQ + + + ++ +K
Sbjct: 2723 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2780
Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6558
P++ +++ ++ K+F + +K E ++
Sbjct: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840
Query: 6559 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6617
+L+ ++ +D + R + L ++L +Y+ ++ L ++ Q + + +
Sbjct: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
Query: 6618 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6673
++ E I +L KE Q +L T + + KE T + L+ + V
Sbjct: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2960
Query: 6674 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6730
++ H + LE + + + E +E RQL+ + + S+G + L T
Sbjct: 2961 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3016
Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6786
+ Q + SL + ++ + L++ S SD+ Q+ + + + + ++ ++
Sbjct: 3017 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3076
Query: 6787 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6846
LET L+ +Q+ ++ D L+ V ++ E ++ F
Sbjct: 3077 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3132
Query: 6847 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
K+++A + + T +L ++ D ++ +L + Q LL A +E++
Sbjct: 3133 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3192
Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6960
+ +L + S++ + L++ + +E + + I++ L +K F+ + +
Sbjct: 3193 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3249
Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
KQ V+++ Q ++Q +++ ++ + L +N W+ L V ++ L+
Sbjct: 3250 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3304
Query: 7021 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
L +++ ++ L +W +T+E Q+ + V+ +++ + L+ L+ ++ VE
Sbjct: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3364
Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
I++ G + + ++ L L W L + L+ +
Sbjct: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3424
Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7199
+ +N +L L + ++ Q+ + L+DD+ + L + SI Q LK
Sbjct: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3483
Query: 7200 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7245
+ + + + + W EI E+ S LLQ +
Sbjct: 3484 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3540
Query: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7300
+ S + Q+ T L K + + +++ Q+ + LL GL +K D +
Sbjct: 3541 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3600
Query: 7301 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7354
+ + E +K + + A ++ L L++ L + + LC ++ +L Y
Sbjct: 3601 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3659
Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
ET ++L+G++ S + Q R +ELK + ++ LD LN
Sbjct: 3660 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3694
Query: 7415 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7468
E+ L P +E K + N + L+S T++ ++ + +L+ Q F + +
Sbjct: 3695 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3754
Query: 7469 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7526
+ ++ +TE+KL +I Q + + F E+ + I+ ++ G +++
Sbjct: 3755 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3814
Query: 7527 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
+++ KL + + + + +R ++ ++ E E+L WL E +
Sbjct: 3815 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3873
Query: 7587 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
+ +P P + TL + + ++ + + +I + LL G
Sbjct: 3874 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3924
Query: 7645 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7701
E IQEK+ +A +++E KK A L + D ++++ +++ + L
Sbjct: 3925 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3983
Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7750
+ AE + KE + + + D+ +L L +TL A D I +
Sbjct: 3984 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042
Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7810
++++ + WE + + R ++ + + F + L + + + D
Sbjct: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4102
Query: 7811 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
I+ + K +++ +EEI QE + +G L A E ++ + ++N W
Sbjct: 4103 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4162
Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7924
L R+ KL+E + A Q + ++ W+ +LA PI D E +++
Sbjct: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4219
Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
++ E ++ + + + + + + E+LL +++ ++Q L W ++
Sbjct: 4220 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4276
Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
+ R+ K+E +F WL +E + G + EL K
Sbjct: 4277 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4336
Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
Q V + +E +NK L + + A +L+ + NQRW N+ ++ ++L
Sbjct: 4337 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4396
Query: 8105 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8164
+ Q + F + + WLT+ + L + AK +QL + + K E
Sbjct: 4397 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4455
Query: 8165 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8221
++ +G+Q++ + I+++++ L+ + V E
Sbjct: 4456 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4496
Query: 8222 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
L++R+ +LE++ L+ + +H+ D + Q L+++ L +D+
Sbjct: 4497 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4544
Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD-----HSALESQI 8335
+ + D + ++ S + + D+ G K F + V L + S E +
Sbjct: 4545 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4603
Query: 8336 RQL---GKALDDSRFQIQQ--------TENIIRSKTPTGPELDTS------------YKG 8372
++L G++LDD+R + +Q E + S+ EL+ + +K
Sbjct: 4604 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4663
Query: 8373 YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 8432
+ K LG S D+ R LKE+ + L + + + D+W+ + +++ ++
Sbjct: 4664 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVERQ 4720
Query: 8433 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8492
++++ L QF L ++ WL E +L + Q + DI + I K QK +
Sbjct: 4721 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKEL 4778
Query: 8493 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
R + + ++ + E + +S ++ ++ +++ RW+ VC+L + L+ AL Q
Sbjct: 4779 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4838
Query: 8553 QGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
+ FH + H LL L ++ R + ++P D + L D HK+ M+ +L E + +
Sbjct: 4839 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELN 4894
Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
M +L K + +I R + +L +H + L L ++Q+L
Sbjct: 4895 KATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4953
Score = 290 bits (741), Expect = 6e-77
Identities = 817/4617 (17%), Positives = 1774/4617 (38%), Gaps = 529/4617 (11%)
Query: 1370 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1427
S L S+ S LE K + E E+ +KEA SEI + K ++ ++ Q
Sbjct: 629 SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 684
Query: 1428 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1487
KL +T + ++ + +F S +W+ EKE+E A + S + I++ K
Sbjct: 685 AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 738
Query: 1488 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1541
++E++ K +I ++E A+ Q + AR I+A ++ + + Q
Sbjct: 739 DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 795
Query: 1542 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1596
C+E H+ + + E +++ + K A+ K C ++ +K+ +QE M
Sbjct: 796 CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 851
Query: 1597 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1646
+ + L S I A+ ++ N D ++ + ++ +Q E + + E
Sbjct: 852 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 911
Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1705
A + A W+ + + + + E A+R+ E + Q + L +E
Sbjct: 912 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 969
Query: 1706 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1754
VVS +++ +++ S +VAS +K M + L L R+ D +
Sbjct: 970 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1021
Query: 1755 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1814
+ +S V +L +V K + EL ++E + V + + +EV
Sbjct: 1022 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1073
Query: 1815 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1873
+ + L++ + L + + + +DLH + + +L +E ++ + + EF
Sbjct: 1074 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1133
Query: 1874 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
A+ S + L + Q + SM+ D + K +N L+N +A E A V L
Sbjct: 1134 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1190
Query: 1928 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1984
Y K+ E + + I+NL+ T + SE D + A +
Sbjct: 1191 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1233
Query: 1985 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2038
D+ ++ K+I D +T KER KE Q +++ V Q+++ L L
Sbjct: 1234 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1285
Query: 2039 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2094
+ K + + P +D I ++E T +R I ENQ + + Q +
Sbjct: 1286 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1340
Query: 2095 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
+ SK+ E T+KD E + ++ K K++ + S ++
Sbjct: 1341 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1397
Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
E + + +LV T M + D ++LEE L + + E++ W
Sbjct: 1398 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1453
Query: 2214 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2260
+N P + IS+ + + E+L + ++ A +++ + N+
Sbjct: 1454 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1513
Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
L++ K L+ +L F E+ +++L+ ++ +V K K + + ++ + I
Sbjct: 1514 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1570
Query: 2321 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
T+ E L+ + + LKK + Q+ELQ + + + E
Sbjct: 1571 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1630
Query: 2377 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2430
L + LI K +EA QL K + S +E L+K + +++E E K +
Sbjct: 1631 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1689
Query: 2431 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2457
+ S+R G +V+E Q N+L++
Sbjct: 1690 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1749
Query: 2458 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2487
DGQ S+ AV TQ Q L +LS + +Q+
Sbjct: 1750 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1809
Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
+ + ++ L + K + EL F+ + + W+ + E+ ENL
Sbjct: 1810 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1867
Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2605
I ++ + + F S D +S +G L ++ G+ + + CS+
Sbjct: 1868 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1918
Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2661
+ +E R A +L + +K + D+ E L E
Sbjct: 1919 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1978
Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
S+ + ++ + K Q SS + ++ E L + ++ +
Sbjct: 1979 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2038
Query: 2722 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
Q TL+ ++ ++ D + N+ E + + L Q GL E + +++S L
Sbjct: 2039 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2095
Query: 2782 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2818
E ++ AL +I+K+ L + +T D S + Q ++K
Sbjct: 2096 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2155
Query: 2819 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2874
+F++ KE + K+EE+ ++ + + +L + + L D +
Sbjct: 2156 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2215
Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
+Q E ++ ++ L + SL E+ + S L+ + L +K+ E
Sbjct: 2216 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2271
Query: 2935 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2973
D++ + + SC E L ++ + + F + L ++LE
Sbjct: 2272 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2329
Query: 2974 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
L + W+ + L+ T + + G +L+ + TE+
Sbjct: 2330 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2388
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+ L +D++ S L L L+ N + Q+ ++ QW
Sbjct: 2389 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2442
Query: 3080 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3136
L +N T + P + V T +++ + F +E + +K+ + K ELL
Sbjct: 2443 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2502
Query: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
+A + +T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 2503 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2562
Query: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3252
D ++Q++Q +L+E +PQ +L Q + S R
Sbjct: 2563 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2622
Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
+++ ++ ++ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++
Sbjct: 2623 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2682
Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3371
++ + + + Q+++ Q+K+ E + E + + +QL+ + +
Sbjct: 2683 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2742
Query: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
+ L+ A + +Q R F W+D+ + N+S A+L +++
Sbjct: 2743 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2802
Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3485
K ++ + + S + E +G + +E QL+L ++ + ++ KE
Sbjct: 2803 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2862
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEG 3545
K ++ + +Y+ ++ W+ + Q L++ A E ++ L+ LQ +
Sbjct: 2863 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQH 2921
Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLR 3601
++ + +T ++ + + + + +SL Q +L + N+ K +
Sbjct: 2922 FGMVELLNNTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2979
Query: 3602 LMEQKFQQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEE 3657
++ ++ L+ A+E++ S ++ SN+ +Q Q + + A + +V+
Sbjct: 2980 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDL 3034
Query: 3658 VGARAQEILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
AQ+++ E S S + Q + + L QV E+ FLE ++Q + ++++
Sbjct: 3035 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3094
Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
+ ++A +T+ K+ +T++ LK +E L ++ + +
Sbjct: 3095 REMFSQFAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKT 3148
Query: 3775 VKYLEEGEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
K + E +++++ +Q +L + +E + +EF K K +
Sbjct: 3149 CKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3208
Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQ 3888
+ + +E ME QL+ +K Q+ + + + V G+ L++
Sbjct: 3209 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3268
Query: 3889 DVT----LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
T L+ +D + + ++ L + L+ + + L+ + W++
Sbjct: 3269 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-E 3327
Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
LVA ++ + + Q+ K + + + + ++ +G+ + A + K
Sbjct: 3328 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKV 3383
Query: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
+ L + A+ + A+ + LE +TL+ WL+ ++ L
Sbjct: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
Query: 4065 PPLSRAEAIKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNA 4102
++ +Q+ +AL++ +R D++ S D S
Sbjct: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQV 3503
Query: 4103 SVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRR 4159
+ + ++Q L A+ + E+ + +E+ L D + + ++
Sbjct: 3504 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3563
Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
SEL V Q ++K QA +N + E + + T E ++ + ++
Sbjct: 3564 QSELR-------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYK 3615
Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVH 4274
D+ + S ++ E+ LQ R H C + +V +E + E L +A +
Sbjct: 3616 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3675
Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
+ LKK A + K ++ L + ++E + +E +++ + +R+ + D I +
Sbjct: 3676 PKELKKEA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732
Query: 4335 KIQ-VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
K++ + L Q+ EL W E + + D L E
Sbjct: 3733 KVEEIDAAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791
Query: 4394 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4453
+ + ++ L+K ++M E+Q ++K L + + + + +R L +A S
Sbjct: 3792 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3851
Query: 4454 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4513
QF + + + + I L + + +Q + + + + ++ + +
Sbjct: 3852 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3911
Query: 4514 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4573
G +L+ E++ E + K ++Y + + R L++ + F + D+
Sbjct: 3912 NKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3970
Query: 4574 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
L++ ++ E ++ Q+++ +N+ + + L TL++ G+ ++
Sbjct: 3971 ILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4030
Query: 4634 NEVDHSY----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLS 4688
D + +KL+ + + I L +++ K+ + + LA K + + L ++
Sbjct: 4031 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIK 4089
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPW 4747
+ + F+R + P + Q+ I +E+ GL E +D +N E + G+P
Sbjct: 4090 DTQ-DFIRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD 4147
Query: 4748 QP---DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
+P + L + + L + + R+ LE+ A +++ Q + + + + +
Sbjct: 4148 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4207
Query: 4805 NE-----ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQI 4858
+ ET+ + E+LK + S A Q I ++R+ E L L + E +H +
Sbjct: 4208 SPIGTDLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTV 4261
Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLD 4914
Q ELKL+ ++ E + + ++ ++ FQ + L WL + LS +
Sbjct: 4262 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4321
Query: 4915 LNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD 4974
+ + I+ E+ K + Q +V + + A++ + + +++L++ L L++
Sbjct: 4322 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4381
Query: 4975 GDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENL 5032
++ E R+ L Q + ++ + WL D + L LA L E+A+E L
Sbjct: 4382 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQL 4440
Query: 5033 KSHME----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
HME F + E+ + S +++ ++A + + +++Q + +L+ + + +
Sbjct: 4441 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETK 4496
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEH 5145
+ L+ ++ + ++ I + E+ L S SL+ + + + EH
Sbjct: 4497 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEH 4552
Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
K + VNS E+I+ L++ + L+ + + +V RW ++ ++ +
Sbjct: 4553 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4612
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
L+DA F+ K E +++ + L ++ T L H F L +
Sbjct: 4613 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4672
Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKD 5324
S + S+ E+ L + + D +++K T GK V+++ K
Sbjct: 4673 SVYDTTNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKL 4723
Query: 5325 REMV------ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKM 5377
E + + ++ W+ Y P + D + ++ +++ NH+
Sbjct: 4724 EEALLFSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK------ 4772
Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
+K LG T S+Q AL R+ I+ + K QELS + + +
Sbjct: 4773 ---AFQKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4820
Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
+ T+L+A EE L+E A ++ L +G L
Sbjct: 4821 CALSISKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD- 4868
Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHG 5552
+ L + H++ +++ E + ++LN+A + + + + + I WI +
Sbjct: 4869 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 4928
Query: 5553 TIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRE 5612
+AW Q R L + ++ LEA+ LQ+ + T+K + + + E
Sbjct: 4929 VLAWAKQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---E 4979
Query: 5613 TEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
EE++ +I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 4980 IEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5036
Score = 235 bits (599), Expect = 2e-60
Identities = 796/4534 (17%), Positives = 1666/4534 (36%), Gaps = 676/4534 (14%)
Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 591 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 646
Query: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 647 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 692
Query: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 693 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 747
Query: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 748 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 798
Query: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 799 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 857
Query: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
+S + + + +T+ + +I ++ AN
Sbjct: 858 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 917
Query: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
+A K C ++ E Q++ L LW HE
Sbjct: 918 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 976
Query: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 977 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1030
Query: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 1031 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1083
Query: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 1084 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1142
Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 1143 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1197
Query: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 1198 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1253
Query: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 1254 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1313
Query: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 1314 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1371
Query: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 1372 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1417
Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
+ D+L++ E + L+ + E +++L + +S
Sbjct: 1418 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 1459 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1512
Query: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
Query: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1632
Query: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 1633 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1687
Query: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 1688 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1747
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 1748 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1804
Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 1805 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1864
Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
++ T L + K +E+V+S+ L I + G + E
Sbjct: 1865 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1924
Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 1925 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1984
Query: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
+ + D + L + + LQ + Q + + T E D S +P
Sbjct: 1985 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2039
Query: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
D + L+ + ++ ++E + + + ++ ++ +W+ E + + +
Sbjct: 2040 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099
Query: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
N + + + +++ + + + + ++ ++ + ++ QA L++
Sbjct: 2100 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2159
Query: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
R+ + L +++ L+ +++ E L ++ + + ++
Sbjct: 2160 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2219
Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
M + LE K +E HSLLK G + K L + L K + KE+
Sbjct: 2220 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 2271
Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
T++++ + F K+L WI E + + + +P + L K
Sbjct: 2272 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2330
Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
LQ+ P ++ V G +L L+ VT
Sbjct: 2331 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2390
Query: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
+K + + Y+DL + K+ + L K+ + E + +WL +M+
Sbjct: 2391 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2450
Query: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
P +T +++T +Q K
Sbjct: 2451 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2510
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
M+ EI LN L + + + +++L +A+LKQ + + G
Sbjct: 2511 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2570
Query: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
+ +T ++ Q L LQ+ +R+ +Q A A Q L + P R +Q+
Sbjct: 2571 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2624
Query: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
A+ ++ + L CD + A VK+T Q +++ KL N +
Sbjct: 2625 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2679
Query: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
+ L+ A + Q +++ +++ +AQ + + VK+ + +A ++ +E
Sbjct: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2736
Query: 4196 VNKLTKKEESPEHKEINHLN----------------DQWLDLCRQSNN------------ 4227
+ K K E + HL WLD ++ N
Sbjct: 2737 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL 2796
Query: 4228 -LCLQREEDLQRTRDYHDCM--------------------NVVEVFLEKFTTEWDNLARS 4266
++ +D +T M +++ L T WD +
Sbjct: 2797 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2856
Query: 4267 DAESTAVHLEALKK--------------------------LALALQERKYAIEDLKDQKQ 4300
E E+L+K L E + +I LK ++
Sbjct: 2857 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK 2916
Query: 4301 KMIEHLNLDDK------------ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4348
+M +H + + E+ KE + + Q D++ ++ LE +
Sbjct: 2917 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT- 2975
Query: 4349 VQSRFQELMEWAEEQQPNIAEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIK 4406
+F+E E ++E + + A +Q D +Q +L + + LK +
Sbjct: 2976 --QKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3033
Query: 4407 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4466
A R+ DL V++ + S S V + + Q L++ + EK FL Q
Sbjct: 3034 LAKRLAQDL------VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3087
Query: 4467 SQIQQHERKI--MFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMK 4522
Q R++ F E L V + +T + + ++K + ++ L A K
Sbjct: 3088 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3147
Query: 4523 E-----VTEQEKSEVLG---KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4574
TE+ +++G L+ L + +L + R +++E + + F +
Sbjct: 3148 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3207
Query: 4575 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILP 4631
L++A+ + + E+ ++ QL ++ + Q E E L Q GQ ++
Sbjct: 3208 SILLQKAEEHEESQGPVGMETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQ 3265
Query: 4632 S-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4690
S L L+ + ++ + + ++QEA+L + +E + +
Sbjct: 3266 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3325
Query: 4691 EAQFLRMSKVPTDLAVEEA-LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQP 4749
E + V +A + Q + +LD+ V+ + ++ E +T +P
Sbjct: 3326 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADK 3382
Query: 4750 DKMLHLVTL----YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4805
K+L ++L + L + E R LE + Q+ + + L L ++ E+ VN
Sbjct: 3383 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVN 3440
Query: 4806 EETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS---- 4860
E + + KL+ + +L+D I + + L L+ + + +QS
Sbjct: 3441 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500
Query: 4861 ---WQGELKLLTSAIGETVTE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL 4915
W E++ + + E + + C +++ F + ++WL V +LS D
Sbjct: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDY 3555
Query: 4916 NLQDIQEEIRKIQIHQEEVQSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELS 4971
+ + + ++ ++++ QE++ LR N L+ E K T E++ ++ L +
Sbjct: 3556 STEGLWKQQSELRVLQEDI--LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIK 3611
Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEE 5030
DI + TL + +R + + WL+ + ELL L E A +
Sbjct: 3612 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3671
Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSG 5090
E + L+ L+ + + L L+ +E LE+ VA R + +S
Sbjct: 3672 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
Query: 5091 AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
+V+ + + + +A + + + +TEKKL ++ + +L K
Sbjct: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTM 3790
Query: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
+ + I L + ++ ++ K ++ + + V + + + + ++ LE A
Sbjct: 3791 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3850
Query: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
F ++ + + Q + A L E H + + + +
Sbjct: 3851 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3910
Query: 5271 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5330
+ + +L+ +PGE + ++ A ++E VK + + +
Sbjct: 3911 MNKTGPQLLE----LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3966
Query: 5331 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEK 5384
+I+ + ++ E L P I A++E+++ ++E N ++EK+ +++ E+
Sbjct: 3967 KIDQILESLERIVERLRQPP-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4025
Query: 5385 YLGLYTILPSELSLQLAEVALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
+ ++S + + LD + I + I ++E E EL+ +K D
Sbjct: 4026 MIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHM 4082
Query: 5443 TILTKLKAKTD-------------NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ 5489
+++ +K D V Q + + + EE+DG +L + + +
Sbjct: 4083 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 4142
Query: 5490 NGQLGKPLAKK-IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 5548
G+ KP+ KK I +L + ++R+ KL +A +Y + L+ + W++
Sbjct: 4143 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD---- 4198
Query: 5549 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
+A G +A S S + + +EE K+ S EA ++++ E+++ Q
Sbjct: 4199 IAGGKLA--SMSPIGTDLETVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAEL 4247
Query: 5609 LGRETEELRQMIKIRLQNLQDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L ++ E + +QD ++K E + Q LE A L +
Sbjct: 4248 LLKKVTE-----ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4302
Query: 5665 LKEQLSHRQHLLSEMESL--KPKVQAVQLCQSALRIPEDVVASLPLCHAALR-------- 5714
L L+H + LLSE + + PK ++L + + + DV+A A +
Sbjct: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIES 4361
Query: 5715 -LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------- 5763
EEAS LQ+ Q + + EQ +Q++ + +G H EIED
Sbjct: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421
Query: 5764 -----KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
KP+ + + Q++ H E+ + +E SL K + + + +
Sbjct: 4422 HLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4480
Query: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
++ L E E ++ +L + + + ++L + + E T + S
Sbjct: 4481 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS---- 4536
Query: 5879 CRSPSPVANTDA-SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 5937
PS + +T +++ + +++ R Q ++ + + + F + L
Sbjct: 4537 --RPSLILDTVLFQIDEHKVFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLL 4592
Query: 5938 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5997
+Q WE + + E+ R+L +A +R +++ ++ + +E E L E P+
Sbjct: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPD 4652
Query: 5998 ---SQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
+Q+A+H+ + L + + + + L ++ AD + L L L+ L ++
Sbjct: 4653 KIKTQLAQHKE-FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKW 4709
Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
TI K+ ++ LEE L L + ALQ L WL + L P
Sbjct: 4710 DTICGKSVERQNKLEEAL---LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVH 4758
Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
+D+ L+D + K + + + L+EG ++D++ + +++ L
Sbjct: 4759 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELST 4815
Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQ 6225
+ KQ ++ ++ EE + A + EWLA+A T
Sbjct: 4816 RWETVCALSISKQTRLEAALRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDED 4870
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
++ + Q KE ++L E+++ L + G+ +L
Sbjct: 4871 ALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4904
Score = 224 bits (570), Expect = 4e-57
Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)
Query: 500 LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 551
L+K + EL +L L E S + W+ K + + Q + + +E +K
Sbjct: 2414 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2473
Query: 552 FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
FE Q Q LK ++ + EA + + E ++W+ L+ +
Sbjct: 2474 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2533
Query: 608 LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 654
LEE +N ++ A L+ WL + E MLN + +
Sbjct: 2534 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2593
Query: 655 QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 711
Q+ + AG ++ D + +K+QL + +W L ++ D+
Sbjct: 2594 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2653
Query: 712 EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 761
+Y + +LS ++ KLS L VS MN +L + Q+++ ++++ V A
Sbjct: 2654 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2713
Query: 762 --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 814
+ K +L + S Q EG K K + + ++ C S ++ S+
Sbjct: 2714 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2773
Query: 815 IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 871
L+ +++ + K++ + +++ + + S L Q H ++ +A EN L L
Sbjct: 2774 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2829
Query: 872 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 931
+GS+ + L+ + ++D +Q+ + + ++K +K+ VET + K
Sbjct: 2830 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2887
Query: 932 FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 989
+ + E++ L A EG + L + + F ++ N+ L C+ +++
Sbjct: 2888 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2946
Query: 990 PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1046
++ + +Q+ +LH + L+ ++ E R L +E +LD
Sbjct: 2947 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3003
Query: 1047 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1106
L Q S K + + + + + ++ L + L L V D+ GT V L+
Sbjct: 3004 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3058
Query: 1107 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1164
E A ST + +++ + + + F + I +Q E A G
Sbjct: 3059 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3118
Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
++ K+ ET+ +L+ L ++S + A K + + LV + ++
Sbjct: 3119 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3169
Query: 1225 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1265
E K + D Q +E +K LEE S KE + Q ++T
Sbjct: 3170 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3228
Query: 1266 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1321
E + + + + +++ + + K++DV Q + Q+ H +L + +
Sbjct: 3229 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3287
Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1379
L + ++ ++Q L RF+ E+++ ++ T ++++ S + + + +++
Sbjct: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3346
Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1437
++ K + + E + +E +I P +K + +Q + + + L + E
Sbjct: 3347 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3406
Query: 1438 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1494
+ +E + F E L+ W+T EK L + T +S ++ QI+Q K +I
Sbjct: 3407 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3466
Query: 1495 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1554
+ + QS + + +++KL + + E++E + + L
Sbjct: 3467 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3526
Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1607
+ F E+ ++ ++E DKL+ + + +TE +VLQE D+ +++
Sbjct: 3527 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3583
Query: 1608 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1665
A+ ++ + + + A++ +Y+DI + + + LE L +RL
Sbjct: 3584 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3643
Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
TWL++ E + S E + + +++ + L+ E + + L ++ +L
Sbjct: 3644 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3702
Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
+ + ++ + + +ER+R + I +++ + + + QQFD+ + WI
Sbjct: 3703 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3762
Query: 1786 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
+L + +I + Q + L K E+ K + L K+ + E+ ++
Sbjct: 3763 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3822
Query: 1844 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
K + + ++ Q+ R L L S + +F +++ L L + Q++ +
Sbjct: 3823 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3881
Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1957
E + + + + Q + + +D + L++ E AD L
Sbjct: 3882 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3941
Query: 1958 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2017
+++ EA + + F D+ +++L+S+E I ER + + ++++
Sbjct: 3942 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3998
Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2071
+ + ++ + LK + +++ KD++ A V +++++ W++
Sbjct: 3999 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4057
Query: 2072 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2121
L+ E + + +++L ++ ++ S ++ + T I+D ED +
Sbjct: 4058 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4108
Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2177
K ET + +++ Q++LD + G L++ K I + + +S
Sbjct: 4109 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4168
Query: 2178 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2237
W D +KLEE M + ++ D + + D ++ + + M+ ++L+ + E L
Sbjct: 4169 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4224
Query: 2238 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2294
K+F+SE + + +E L+ + + L K + D ++ LM+ KL + +E
Sbjct: 4225 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4281
Query: 2295 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2349
+ L+ Q + ++++ W T E L + E L K +Q ++
Sbjct: 4282 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341
Query: 2350 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2408
+ QS + + + N L E +L + L ++ + V + + + L +L
Sbjct: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4401
Query: 2409 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
K F +++ Q+W + S G + + +L+ + + + ++
Sbjct: 4402 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4461
Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
Q+GQ + A K ++I + I E++++ + + K L++ + F + +
Sbjct: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4521
Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
W+ + E+ N + + + HKV F E+ + RE + +L + G L +
Sbjct: 4522 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4577
Query: 2588 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2643
Q+ L LL S Q+ +++ E+ RS A + + EA + W++
Sbjct: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637
Query: 2644 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2702
+ L D ++ +L+Q ++ G + G ++S +
Sbjct: 4638 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4697
Query: 2703 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2762
+ L L++ W I SV Q+ LE + + + L W+ V+ ++
Sbjct: 4698 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4757
Query: 2763 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2821
+ L+D+ ++ E T ++ L +REL E +D S+ +EL T++
Sbjct: 4758 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4817
Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
+ ++ K ++E ++ + VH +WL A++ L + D A + +
Sbjct: 4818 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4877
Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
+ KE + E + L++ ++ V + + +RA ++E+ + +
Sbjct: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4934
Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
+ L S +A G +A+ ++ LE A L+ WA+ T L K D+E++
Sbjct: 4935 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 4977
Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
QEI E++K+ + E F +++ V + K Y
Sbjct: 4978 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5011
Score = 213 bits (543), Expect = 5e-54
Identities = 145/433 (33%), Positives = 223/433 (51%), Gaps = 65/433 (15%)
Query: 16 NVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKL 75
+V++R +DE++ VQK+TFTKWIN HL K + V+DL+ED++DG L++LLEVLSG L
Sbjct: 24 DVLERYKDERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTL 81
Query: 76 PCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQI 135
P E+GR R H + N+ AL +L+ R++KLVNI + DI DG P + LGL+WTIIL+FQI
Sbjct: 82 PREKGRM--RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQI 139
Query: 136 EELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQ 195
++ V+ E+ +AK+ LL W Q
Sbjct: 140 SDIH-------------------VTGESEDM------------SAKERLLLWTQQATEGY 168
Query: 196 TGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRL 255
GI ++F WR G F+++IH RP+L+D+ TV +SN NLE AF +AE ++G+ RL
Sbjct: 169 AGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRL 227
Query: 256 LDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKRE 315
LDPEDVDV PDEKS++TYV+ +P + +G +++ + + N V +
Sbjct: 228 LDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYLIQW 286
Query: 316 DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHLIQP 371
R M ER + L ++Y FK + + K K++ L++
Sbjct: 287 IRHHVTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEI 340
Query: 372 LHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITV 431
G++ L Q ++ +W G + + E ALR E+
Sbjct: 341 WIEFGRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPEVER 382
Query: 432 QQVHEETANTIQR 444
++ ++ AN +QR
Sbjct: 383 LEMLQQIANRVQR 395
Score = 162 bits (411), Expect = 1e-38
Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)
Query: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 1009 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1066
Query: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 1067 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1126
Query: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 1127 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1171
Query: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1222
Query: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 1223 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1282
Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 1283 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1342
Query: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 1343 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1402
Query: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 1403 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1462
Query: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
EK + S QK S KE +T L +K +
Sbjct: 1463 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1522
Query: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 1523 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1582
Query: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 1583 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1636
Query: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 1637 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1696
Query: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
W+ ++ + H + T
Sbjct: 1697 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1756
Query: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 1757 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1816
Query: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 1817 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1876
Query: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 1877 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1936
Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 1937 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 1995
Query: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 1996 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2052
Query: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 2053 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2112
Query: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 2113 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2172
Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 2173 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2227
Query: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 2228 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2286
Query: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 2287 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2344
Query: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
+ S+ NL + A A T+ E SI++ ++
Sbjct: 2345 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2404
Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2464
Query: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 2465 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2524
Query: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 2525 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2584
Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 2585 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2644
Query: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 2645 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2700
Query: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
V E DLS ++ +A S EG + KD + +
Sbjct: 2701 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2755
Query: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
SA S Q +Q+ + A D++ + Q + I +K L +K + K L S
Sbjct: 2756 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2815
Query: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
+ ++ E+ L + + S + L +T W+ Q +E ++K++L+K
Sbjct: 2816 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 2870
Query: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
++ + ++W W+ + LE+ ++ D E I KLK LQK +D ++
Sbjct: 2871 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2927
Query: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
+N + + + D + + D V L + L++ + + F E+S
Sbjct: 2928 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2987
Query: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
L E +D + SN +LQ K L +KH++ L QD+
Sbjct: 2988 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 3044
Query: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
+ +++GT + +V I L ++V LE KL + Q + S
Sbjct: 3045 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3101
Query: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
DELD+ V GR QK
Sbjct: 3102 AEFDDELDSMAPV----GRDAETLQK 3123
Score = 96.3 bits (238), Expect = 1e-18
Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)
Query: 6806 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 610 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 662
Query: 6863 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6922
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 663 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 714
Query: 6923 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 715 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 766
Query: 6983 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 7041
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 767 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 824
Query: 7042 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7099
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 825 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 877
Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7154
+T + + +I + D +SH+ + I+ EA
Sbjct: 878 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 937
Query: 7155 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 938 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 997
Query: 7209 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7253
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 998 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1057
Query: 7254 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7293
Q++ EDR ++ +D + V I + L K L
Sbjct: 1058 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1116
Query: 7294 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 1117 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1173
Query: 7354 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7407
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 1174 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1233
Query: 7408 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7456
+L + + + KE ++ L W + Q R L+ L
Sbjct: 1234 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1293
Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 1294 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1349
Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1350 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1394
Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
+ E L V + Q + D ++ E+
Sbjct: 1395 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1430
Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7692
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1431 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1484
Query: 7693 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7750
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1485 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1532
Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7806
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1533 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1584
Query: 7807 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7852
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1585 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1644
Query: 7853 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7905
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1645 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1704
Query: 7906 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7930
SE A K ++ S EE Q LN+Q
Sbjct: 1705 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1764
Query: 7931 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7985
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1765 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1823
Query: 7986 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 1824 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1882
Query: 8045 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8092
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 1883 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1942
Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8146
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 1943 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2000
Query: 8147 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8204
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 2001 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2060
Query: 8205 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 8260
++KL ++ L R L ++D L W SL P S+ L
Sbjct: 2061 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2110
Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 8319
+++ + E+ +S+++ ++ ++ M PS Q KD R
Sbjct: 2111 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2160
Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
+ S H +++ +L ++ ++ + + +KT E+D K +L
Sbjct: 2161 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2219
Query: 8380 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
S LEHK E SL ++ H + A V+++ L + E +K+
Sbjct: 2220 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2277
Query: 8439 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 8475
++ F + S+ +W+ +T ++ LE ++L+ +
Sbjct: 2278 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2337
Query: 8476 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 8520
+T E+Q L L AV I ++ + + E T +++E +
Sbjct: 2338 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397
Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
+ ++ ++ ++ + LL++ L L + Q E S ++ L+ +++ +
Sbjct: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457
Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
+ D E ++ +Q + EL ++ +V L+D +LL E D EA
Sbjct: 2458 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2507
Query: 8641 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 8685
R K +L E+ +EL +L L+ SS+ + L W EL S +
Sbjct: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2566
Query: 8686 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 8745
P S PN T R + + + P LS PG S RG + L
Sbjct: 2567 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2624
Query: 8746 RA 8747
A
Sbjct: 2625 AA 2626
Score = 54.7 bits (130), Expect = 4e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 366 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 4600 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4648
Query: 425 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 4649 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4692
Query: 479 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
Query: 525 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 4753 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4807
Query: 585 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
Query: 639 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
Query: 692 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
Query: 747 QD----LEDIEQRVPVMDAQYKIITKT 769
+ +E++ ++ P +D +TKT
Sbjct: 4988 AEHQTFMEEMTRKQPDVDK----VTKT 5010
Score = 33.9 bits (76), Expect = 7.3
Identities = 90/474 (18%), Positives = 181/474 (38%), Gaps = 61/474 (12%)
Query: 8169 QGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 8228
Q +QL+++ A + +E+ LR C V+ + + +L + L+ +
Sbjct: 458 QADQLVQR-----VAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ 512
Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
+ S L SL SS+++ L+ + S + TPA P
Sbjct: 513 TLHPSLTSGL------TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS----- 561
Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG--DHSALESQI-----RQLGKA 8341
L + S + E Q K +R + S D + E +I + L
Sbjct: 562 -GLVPNFSSGV------EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 614
Query: 8342 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
+D+ + Q+ +TE S P+ ++K + + E SS+ E K+ E + +
Sbjct: 615 VDEMQVQLDRTE--WGSDLPSVESHLENHKNVHRAIEEFESSLK-----EAKISEIQMTA 667
Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8461
P + A + R E A+ L+ +++L F S + WL + EE
Sbjct: 668 P-------LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
Query: 8462 ELEQLQRLELSTDIQTIELQIKKLK----ELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
E E++ D I + K EL + +D ++ I S+ + + +
Sbjct: 721 E-------EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPAR 773
Query: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHG--LLLMLENIDRRKNE 8575
++ + M +W + L + +++ + F++ L L++ +RK
Sbjct: 774 LTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK-- 831
Query: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDC 8628
D + L+D ++ M+ K ELL+ + +A+L + ++ + +DC
Sbjct: 832 -YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 884
Score = 33.5 bits (75), Expect = 9.6
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 375 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
Query: 427 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 4753 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4811
Query: 484 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 4812 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4871
Query: 536 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 4872 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4915
Query: 592 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 4916 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4958
Query: 652 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 4959 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5009
Query: 712 EY 713
Y
Sbjct: 5010 TY 5011
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 372 bits (955), Expect = e-102
Identities = 717/4026 (17%), Positives = 1587/4026 (39%), Gaps = 438/4026 (10%)
Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 959 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1015
Query: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
Query: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
T +V +Y+ G S +R +SL E ++ E +K +
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1132
Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1453
+K+A + P +KQ K E++ ++ L E ++T+++ K D +
Sbjct: 1133 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1186
Query: 1454 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1506
E + E + L L+ S ++ D+++ + + QE + KL I L +
Sbjct: 1187 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1246
Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1566
++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1247 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1303
Query: 1567 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1626
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1304 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1345
Query: 1627 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1673
A++++ E + +++ +E +T +ENLL ++K+ + T +
Sbjct: 1346 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1401
Query: 1674 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1713
G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1402 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1461
Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1462 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1519
Query: 1774 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1828
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 1520 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1579
Query: 1829 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
K+ + ++ A D F+ V+ L L + Q
Sbjct: 1580 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 1636
Query: 1877 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1930
+ S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++ +
Sbjct: 1637 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 1695
Query: 1931 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1988
A+ L S + + T D + G E + + + + + QD +
Sbjct: 1696 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 1755
Query: 1989 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
E+L + ++E ++ ALQ + LE ++ + + + +K K+ +
Sbjct: 1756 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 1815
Query: 2049 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
D + A + ++ L + + E + L + ++NL + LE +
Sbjct: 1816 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 1875
Query: 2108 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2162
+ T + KD +L Y Q+ F KHL S LK+I S
Sbjct: 1876 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 1921
Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2216
+ +D ++K ++S+K +E D ++ + V S +++++ + +
Sbjct: 1922 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 1975
Query: 2217 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2269
+ + + + + AE+L K E K + +L+ E+ KVN+ L L +
Sbjct: 1976 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2034
Query: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2328
TP AK I V G + + +T E+F + T +++ +
Sbjct: 2035 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2076
Query: 2329 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
+ + L +KD EL ++ S + QE +++ + + T
Sbjct: 2077 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2135
Query: 2389 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2448
EAV KTQ +S E +++ + QE L+ KL +
Sbjct: 2136 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2169
Query: 2449 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
L + + T A KQ+ +T+ + ++Q + + +Q
Sbjct: 2170 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2206
Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2207 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2264
Query: 2569 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2624
+ ++L+ GQ +LS G G + QL Q +T + C A+
Sbjct: 2265 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2324
Query: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2682
+ + L+S+ + + ++L+ + + D + ++L Q + + + + ++K+
Sbjct: 2325 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2384
Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2385 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2443
Query: 2743 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2793
+ W+++ +Q HP+ + LD L+S++ + +D ++ L +
Sbjct: 2444 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2494
Query: 2794 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y + V
Sbjct: 2495 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2553
Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
W+ Q L +IK +D E G + +++++SL E+ Q+
Sbjct: 2554 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2595
Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
EL++ +L + + ++ V L V + + + Q +
Sbjct: 2596 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2653
Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
+F + K +QL + + + + + L LQ + + LK Q++ R +
Sbjct: 2654 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 2713
Query: 3031 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3071
+DL + G + +E++ L Q + C E LQ +
Sbjct: 2714 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 2773
Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3131
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 2774 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 2833
Query: 3132 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3191
L+ GI+ + A + +E +E ++++F + L K
Sbjct: 2834 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 2887
Query: 3192 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3246
E+ HE S + + QQ + + EP L+ K Q + W GQ +A
Sbjct: 2888 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 2941
Query: 3247 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 2942 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3001
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
++ + P+++ V+ ++ + + L + +++ +++I GE + P I +
Sbjct: 3002 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3061
Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
QL + W +LL+ QLEG + + + + W+ ++E L E +
Sbjct: 3062 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3121
Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3475
+ + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3122 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3181
Query: 3476 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3532
IQE++ ++ + + + D WL + +KL + SV + ++ L
Sbjct: 3182 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3241
Query: 3533 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
R LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3242 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3299
Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWHEE 3647
+ R + +++ WL E E +S T+ + Q+ ++KK +
Sbjct: 3300 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3359
Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
A D + EV + E++ +R G + + RY+ + + ++++ ++ I
Sbjct: 3360 NKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3416
Query: 3706 SLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
++ + + + W T K + + + D+ + +K T+E+L +
Sbjct: 3417 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKD 3471
Query: 3763 LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3822
++ + G + + E E + ++K++ ++ + + ++ LE+ L +F
Sbjct: 3472 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3531
Query: 3823 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
+ + L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G
Sbjct: 3532 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3591
Query: 3883 LLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
LLEL + ++++K + Y + K+ +L+ + ++ ++ ++ + L +
Sbjct: 3592 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 3651
Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC------ 3994
+ RL P + ++ +E I +Q++ +K + ++ + L+ +G+ +I +
Sbjct: 3652 IVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 3710
Query: 3995 --ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
A +Q KL Q N+H ++ + + A++ + H+S T++
Sbjct: 3711 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIK 3763
Query: 4047 QCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLS 4100
Q ++ ++ P ++PS + AE I++ LQE+ ++L L + C +
Sbjct: 3764 DTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPD 3821
Query: 4101 NASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4156
VK + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 3822 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 3881
Query: 4157 KRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHL 4214
++LE + + ++K F + +Q + + + L KK EES +H + L
Sbjct: 3882 SPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 3939
Query: 4215 NDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4271
+ W L + N + E L + ++ + +L +
Sbjct: 3940 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 3999
Query: 4272 AVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE 4329
A+ +E K L + + +E + +IE ++ ++ + L QRW +
Sbjct: 4000 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4059
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ +++ Q L + ++L +W + + ++ + P+ A+ L H+
Sbjct: 4060 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4119
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+C+ EAK+ KSL++ +++A + I + +++ + + + +R+ L
Sbjct: 4120 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4179
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4509
+AL+ +F ++ + + Q E+ + L+ D V Q+ K + +++ +
Sbjct: 4180 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4239
Query: 4510 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4569
+ L G L +Q+ + L +QS ++ V+Q+ R + L+ K F E
Sbjct: 4240 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4299
Query: 4570 DFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTI 4629
+ K WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4300 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4359
Query: 4630 LPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L
Sbjct: 4360 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4419
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTG 4744
+E Q V D ++ ++L D +A E+ +V L + EG R
Sbjct: 4420 RVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4477
Query: 4745 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
W +M L T + + + + + LE +E + L L + EQ+
Sbjct: 4478 S-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLR 4534
Query: 4805 NEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4859
LP +E + + L++ L + T + + P + +H I
Sbjct: 4535 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4594
Query: 4860 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4919
+ + + + + S + I Q + L WL+ + L+ D + +
Sbjct: 4595 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEV 4649
Query: 4920 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
I +EI +++ E Q+ + M + +K TK + +AD + + LD
Sbjct: 4650 IPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG 4708
Query: 4980 ALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLA 5019
R ++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 4709 RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFA 4768
Query: 5020 GNGLDV 5025
D+
Sbjct: 4769 NFDFDI 4774
Score = 340 bits (873), Expect = 3e-92
Identities = 720/4013 (17%), Positives = 1591/4013 (39%), Gaps = 492/4013 (12%)
Query: 442 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 786 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843
Query: 502 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
K++ + L +L AE+ +K + K E+V + ++N +S + E
Sbjct: 844 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900
Query: 551 KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
+ F E ++ ++ K E + D E+A+ +++ +W+N+ V++
Sbjct: 901 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 953
Query: 603 SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
+ LE + + Y +T L W++ E NQ EN+K + N +
Sbjct: 954 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1013
Query: 657 HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
M + + E S +K L +++ + + VK+ D +
Sbjct: 1014 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1070
Query: 710 KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
+E+ D +A T +++ ++ + ++K L ++ + +E+ + K + K
Sbjct: 1071 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1126
Query: 770 AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
I+K + ++ GK F+ E+++ KE S L Q L
Sbjct: 1127 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1186
Query: 819 ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
ELEKQ+ + +S + +E+Q+S K + + + Q+ K+ L
Sbjct: 1187 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1246
Query: 871 ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
+I G+ ++K+ + L+ D + +A++ ++ +K+ G+
Sbjct: 1247 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1305
Query: 919 -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
K +E +L K E+S+ EL+KV+ A +E E+ ++L T
Sbjct: 1306 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1365
Query: 965 EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
+ + LD +L D+ ++ + +Q +++ H Q D + E +
Sbjct: 1366 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1417
Query: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
LL +D + + + +E + ++ K EKII +H+ V + + L EK+
Sbjct: 1418 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1469
Query: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
Q + EE K ++ +++ L E + T+ L E+ +K+ DYT
Sbjct: 1470 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 1521
Query: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
EF W+ +E +L+ ++ A D ++KR + ++ +G+ S +VL
Sbjct: 1522 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1581
Query: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
S + + + KL + +L S+ + +N D V + +++
Sbjct: 1582 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1641
Query: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
L++G + + A K L +E + + L ++TK + + Q + + ++
Sbjct: 1642 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 1700
Query: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
L D L ++ TLD L +S + ++Q+TL + + + ++ +
Sbjct: 1701 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 1760
Query: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
+ SS + L+ ++L+ +S + ++ + R SI E VK+ E P
Sbjct: 1761 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 1818
Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
LQ + K + + + +E + ME +KTK + F + E L ++ K + L
Sbjct: 1819 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 1878
Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
++ + ++ + E + L + + + A + K +
Sbjct: 1879 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 1938
Query: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
+ +E+ + + + + Q F+ ++ ++ + E
Sbjct: 1939 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 1998
Query: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
ED + K E KV + LC + ++++ A +A S V+N +
Sbjct: 1999 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2058
Query: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
S ++ + YED+ K++ L L+ Q+ ++E S+ + WL+
Sbjct: 2059 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2118
Query: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
+ A+ + D A + +VE L+ V KL +L E
Sbjct: 2119 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2178
Query: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLF 1784
K M L ++D +W++L Q+ R L+ QF + W+ +L
Sbjct: 2179 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2235
Query: 1785 LSELQTTS-----------EISIMDHQVALTRHKDH------AAEVESKKGELQSLQGHL 1827
+S L S ++ I+ + A TR + + S+ GE SL+G +
Sbjct: 2236 VSVLGPLSIDPNMLNTQRQQVQILLQEFA-TRKPQYEQLTAAGQGILSRPGEDPSLRG-I 2293
Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA---------------- 1871
K + L G+ D ++A + Q L L+
Sbjct: 2294 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2353
Query: 1872 --------EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAA 1923
+ L++ + ++Q ++ ++ ++ ++ S L++++ A + ++ LE
Sbjct: 2354 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGIL 2412
Query: 1924 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD-------AL 1976
S + KA+ H+ + S A++ Q Q L TK+ E + L
Sbjct: 2413 KSFKDVEQKAENHV-----QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2467
Query: 1977 AVLKKAFQDQKE--ELLKSIEDIEERTDKE------RLKEPTRQALQQRLRVFNQLEDEL 2028
VL+ +D K+ + L + + E+T E + + + ALQ +L D
Sbjct: 2468 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2527
Query: 2029 N----SHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE---VTWDDTK--------RL 2073
N E++L +KA + ++ P +D+ N LE D + +
Sbjct: 2528 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2587
Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSK-----VLENASSVIVTRTTIKDQ--------ED 2120
+ + Q G+++L+ N +V + V + S+I + +Q E+
Sbjct: 2588 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 2647
Query: 2121 LKWAFSKHE----TAKNKMNYKQKDLDNFTSKGKHLLS---------------------E 2155
+ F + + +K ++ ++ LD S G S +
Sbjct: 2648 MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 2707
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
L K + D + +D + T D L V E + + L + L T+ + G N
Sbjct: 2708 LAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQN 2766
Query: 2216 CVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2268
+ +M + D+ L R E L++ + +K +LE L + ++ + K +
Sbjct: 2767 TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM 2826
Query: 2269 ----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
ET PDL I+ DL + ++ + A+ A+ QVE I + +++K++
Sbjct: 2827 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTIKRLEEFYSKLK 2879
Query: 2325 E---SLMNCAQNETCEA------------LKKVKDIQKE----LQSQQSNISSTQENLNS 2365
E L ++E + L K QKE LQ +Q +++ + L
Sbjct: 2880 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQ 2939
Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFL 2423
K S + L + + + + +++ ++ A LQE+L F ++++ W +
Sbjct: 2940 SAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 2997
Query: 2424 GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2483
+ + + KV++A++ + + + + D +S ++ + +EG+ +
Sbjct: 2998 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3057
Query: 2484 SIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTEN 2542
I +Q++ + ++A L + + L+ + F + LN W+ +E+R N E
Sbjct: 3058 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3117
Query: 2543 LGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
+G + E+ ++++ L + ++ +SL LS R E Q
Sbjct: 3118 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR------EDKDMVQSK 3171
Query: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
SQ+ + + + + Q AL + E + W+ + D+L+
Sbjct: 3172 LDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDY 3229
Query: 2656 SKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLK 2711
S + L K+ S++ +DILL K ++ A+ G + L+ + + +IQ +LE +K
Sbjct: 3230 STEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3285
Query: 2712 EVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI----------EHPLQ 2761
+ DI S TLE + +L W++ V+ ++ E Q
Sbjct: 3286 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3345
Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESFKDTAQEELKTQ 2820
Q KE + +++L + + AL L+ ++RE EK E +
Sbjct: 3346 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED---------NER 3396
Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
+ + +K+ +++ + + A W+ +++L D+ + T +L
Sbjct: 3397 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3456
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
K + EI + ++ + SG ++M + + K+ D V +
Sbjct: 3457 QVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3505
Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD-EEIVECW 2999
+ + S+ L + V Q + E+ L ++ L + E + +
Sbjct: 3506 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3565
Query: 3000 HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY---NCLCLQASK 3056
+ +++ + + + +P + + +L S G+ + ++Y + L Q +
Sbjct: 3566 EEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLYSQIKE 3619
Query: 3057 GCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3116
+ + L + ++ F + + + + + +S ++KI+E +SE++N
Sbjct: 3620 DVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 3678
Query: 3117 GQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDWKNFHSNLHQKE 3165
+ + E L ++ + AK +Q K+ W+N H+ + ++E
Sbjct: 3679 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 3738
Query: 3166 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHC 3225
+ L ++ + F + + T+ + + + D +++Q+ +++ EEI
Sbjct: 3739 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDG 3798
Query: 3226 YEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3283
+ +L+ + +L G+ + + +L+S + +L+ K+++ +L+ +
Sbjct: 3799 LQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAV 3858
Query: 3284 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
Q+ G++ + DW+ A L S +D + + +L+ S +++I+M+ + +
Sbjct: 3859 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ 3918
Query: 3344 GESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E +L+ + E T+Q L +K +W SL I + +LEGAL +Q + +
Sbjct: 3919 AELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 3978
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYV- 3461
W+ E L+E + + + L K +L +VL++ S +E + G + E
Sbjct: 3979 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4038
Query: 3462 -----TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD 3516
Q +L+ L +R++ + E+ ++ + + +R + + +++ + WL + L
Sbjct: 4039 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4098
Query: 3517 QYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALE 3573
L G T + L E+ + S++ + ++ AE D+ +
Sbjct: 4099 ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN 4158
Query: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
+L++ W++ + +L+E +T+ +N Q WL AE+ ++ +R T
Sbjct: 4159 NLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT 4218
Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLL 3691
Q+ + K + EV ++R+++ E+ + S + + + SR++ ++
Sbjct: 4219 VLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQ 4278
Query: 3692 QVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLK 3748
+++E+ + L++ + ++ + S +W + K+ + +A DK+ T +L
Sbjct: 4279 RLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKT-----QLA 4333
Query: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV---- 3804
+ K + HS+ + G R++K + L+ + D + +L++ T+
Sbjct: 4334 QHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSELRDKWDTICGKS 4390
Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
+ LE+ L + +F+D +AL W+ + L + ++ + +K+ Q+
Sbjct: 4391 VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQK 4450
Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
+ SV++++ L+E +D + +K ++ +L + ++ +C++ LEA ++
Sbjct: 4451 ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4510
Query: 3923 DHEDYNSELQEVEKWLLQMSGRL----VAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
E+++S + + +WL + L V PD + +L T+ Q HK M+++
Sbjct: 4511 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPD--DEDALRTLIDQ---HKEFMKKLEEKRA 4565
Query: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
LN GDT++ C +K + + + + + A++ Q L L
Sbjct: 4566 ELNKATTMGDTVLAICHPDSITTIKHWITI----IRARFEEVLAWAKQHQQRLASALAGL 4621
Query: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4091
+++Q+ L+ AWL + L + + ++++ +AL + +T+++
Sbjct: 4622 IAKQELLEALLAWLQWAETTLTDKDKEVIP-----QEIEEVKALIAEHQTFME 4669
Score = 320 bits (819), Expect = 5e-86
Identities = 790/4278 (18%), Positives = 1616/4278 (37%), Gaps = 541/4278 (12%)
Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1337
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 679 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 738
Query: 1338 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1387
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 739 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 795
Query: 1388 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1447
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 796 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 854
Query: 1448 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1507
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 855 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 910
Query: 1508 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1540
Q S F T E +I +L + G+ L+ +
Sbjct: 911 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 970
Query: 1541 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 971 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1023
Query: 1598 LCQAL-ESLSSAITAFS-----------ASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1645
CQ E S+ + + + + V R A + Q++ D+ +
Sbjct: 1024 ECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL----RT 1079
Query: 1646 RQTALENLLAHW--------QRLEKELSSFLTWLERGEAKASSPEMDIS-ADRVKVEGEL 1696
R TAL L+ + +RLE+E S + KA + +S + + E
Sbjct: 1080 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1139
Query: 1697 QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKR 1756
+ +S +K QL E+L ++ +L L + ++ D +
Sbjct: 1140 AGKPPFSKQKISSEEISTKKEQLSEALQTI---------QLFLAKHGDKMTD------EE 1184
Query: 1757 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESK 1816
N L+ V Q+ LL S S+ L E QT+ ++ + + ++ R +++ +++
Sbjct: 1185 RNELEKQVKTLQESYNLLFSESL---KQLQESQTSGDVKV-EEKIVAERQQEYKEKLQGI 1240
Query: 1817 KGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
L + L +G E + G E +++ Q L + +Q
Sbjct: 1241 CDLLTQTENRL-----IGHQEAFMIGDGTVE------------LKKYQSKQEELQKDMQG 1283
Query: 1877 HA-SLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKAL----ESAAVSLDGIL 1930
A +L+ +++ + E +++ + LIE+ LN+A + L E + LD ++
Sbjct: 1284 SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1343
Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL------------------------ 1966
+ A ++ T A QL +I+NLL
Sbjct: 1344 TTA--------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1395
Query: 1967 GTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2023
GT E D K A ++ E LL++ D + T +E L + ++ Q ++ +Q
Sbjct: 1396 GTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1451
Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT-------KRLIHE 2076
+ + + + L+ + + ++ ++ ++ + + L+V ++ +L H
Sbjct: 1452 HQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTHS 1508
Query: 2077 NQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
Q + E+++ + LEN A + T +K Q+ H+
Sbjct: 1509 LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG-- 1566
Query: 2133 NKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRL 2192
DL T G +L K D V T +V KL+ DR
Sbjct: 1567 --------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHR-----EVQRKLDHATDRF 1613
Query: 2193 RVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISNLDNHL------------RA 2233
R S + D++ E S + + + HL R
Sbjct: 1614 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1673
Query: 2234 EELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEIT 2292
E K + ++ ++ + +E+L L + +L D+Q D++ + E +
Sbjct: 1674 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 1733
Query: 2293 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ---NETC--EALKKVKDIQK 2347
L+ +S V+ ++++ W VE SL Q N T + + K +++
Sbjct: 1734 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 1793
Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
++ +QS+I++ E + + SL M L + S +T A ++E
Sbjct: 1794 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 1853
Query: 2408 EK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
K E++ E + FL K A D G V E + +Q + + L+ +
Sbjct: 1854 TKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY-MQESTSEFLEHKKHLEVL 1911
Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
+ + +H + + E+ +++F+ + K+A+ C +L +F+ +
Sbjct: 1912 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 1971
Query: 2527 LNLWIHEMEER-------FNTENLGESKQHIPE-------KKNEVHKVE---MFLGELLA 2569
L WI E ++ F E+LG+S + + K E+ KV + L L++
Sbjct: 1972 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2031
Query: 2570 A----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-----------HQNLLRMTKE 2614
A +++ + G +L+ EG E ++ LTS +++L + K+
Sbjct: 2032 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2091
Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
K+ L + + +E +M W++ + + T DT + Q+
Sbjct: 2092 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQN---KS 2148
Query: 2675 GEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLETLKEVWADIMSSSVHAQSTL 2728
E E+K N+ + + + L +E + L + W ++ ++ Q L
Sbjct: 2149 FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL 2208
Query: 2729 ESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDH 2786
E + + + QL+QW+ + + PL P + +Q +L E
Sbjct: 2209 EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN--TQRQQVQILLQEFATR 2266
Query: 2787 TRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDIMT-VAKEKMRKVEEIVKDH 2842
+L A + + + ED S + +E+L TQ D +T ++ +++ +
Sbjct: 2267 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2326
Query: 2843 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELI--DSREIGASRL 2897
Y + +D L +L +S A ++L K+K+ I + ++I ++
Sbjct: 2327 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQ- 2385
Query: 2898 SRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2956
+ E L+ VK+ E + E+ + L K ++D + ++ +++L S A S Q
Sbjct: 2386 ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2438
Query: 2957 EFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLEGKNTDEEIVECWHKGQEIL 3006
+Q F A L T ++ L +LE D + Q +
Sbjct: 2439 --------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2490
Query: 3007 DALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
AE LK+Q +E L+T K+ + +E L+
Sbjct: 2491 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV-----------KERENKLK 2539
Query: 3067 QRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNISEVST--SLQK-IQEFLSES 3114
+ KA + +Q W+ + + C D + + ++ SLQK + +
Sbjct: 2540 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2599
Query: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
E + N +LS E+ ++T E IQ KV E LH K+ LEN+ +
Sbjct: 2600 ELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-------LHSKKFCLENMTQK 2651
Query: 3175 MKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNR 3232
K+F EVS E + E++ +H+S L + LQ+ + + + Q++
Sbjct: 2652 FKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYLTMLQTQQKSLQALKHQVDL 2708
Query: 3233 LKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3289
K AQ L + SK +V ++ ++ LS EK S L+ + F I
Sbjct: 2709 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 2768
Query: 3290 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKLEALLSVKQEKEIQMKMIVT 3342
+E+ + LDS D L + KLEAL++ KM++
Sbjct: 2769 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 2828
Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E TSP+ + I++ L+++ LL + Q+EG + + + +++FS
Sbjct: 2829 TEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 2882
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSYSSLLETIEVKGAGM----- 3456
+ E + E L K+ EE+ + + G G+
Sbjct: 2883 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 2942
Query: 3457 --TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK 3514
T + +L D+ R++ + ++ + + ++ + +Q L++ W+ +E
Sbjct: 2943 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3002
Query: 3515 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3574
+ + + +++ + LQ + ++ + + E + + P + + L+
Sbjct: 3003 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3062
Query: 3575 LR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNR 3631
L W+A ++ Q + + + + ++EWL T E+++ +
Sbjct: 3063 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3122
Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------DESHVNSRMG------CQA 3679
+ E Q+ Q K +++ + + + + Q + D+ V S++ +
Sbjct: 3123 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3182
Query: 3680 TQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
+ + LL Q L K F E+E++ + +W H ++ +
Sbjct: 3183 QEKSHSRSELLQQALCNAKIFGEDEVELM-----------NWLNEVHDKLSKLS--VQDY 3229
Query: 3739 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3798
T + K+ L VL +D+ + A G +K E ++ ++ + K
Sbjct: 3230 STEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3289
Query: 3799 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3858
++T TLE+ L LA+ + L W+ + + L E ++ E +
Sbjct: 3290 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3349
Query: 3859 YKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKIDQLQSDYQDLCSIGKEHVF 3915
K L++ +++ + S+ E ALLELV L+ + + Y+ + + V
Sbjct: 3350 PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3409
Query: 3916 SLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAG 3975
++A + + ++ W+ + +L++ + +T + QL K EI
Sbjct: 3410 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3468
Query: 3976 FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL 4035
+D +++L G ++ C++ + +K+ + L+ +Y IC Y LE
Sbjct: 3469 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----NYDTICQINSERYLQLERAQ 3524
Query: 4036 QKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS 4095
+T ++ WL+ Q + P P L + + R QE+ R +L+
Sbjct: 3525 SLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EYETLRQQQEEHRQLRELIAE 3577
Query: 4096 MCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--- 4149
+ KT + ++ + +I++K V A L + +IK + + L +A
Sbjct: 3578 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YSQIKEDVKKRAVALDEAISQ 3634
Query: 4150 --------DQQLQNMKRRHSEL--------ELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
DQ L++++R L E+ + +S+ K+ ++ Q T+
Sbjct: 3635 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 3694
Query: 4194 EKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCLQREE---DLQRTRDYHDCM 4246
++ ++ + + K + DQ + + + L +RE D+ + C
Sbjct: 3695 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 3754
Query: 4247 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ------ 4300
++ + K T ++ D E + +K+ A + + I+ L+++
Sbjct: 3755 HMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 3810
Query: 4301 -KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4359
++I DK +VK+ L W L K +I ++ Q Q + +W
Sbjct: 3811 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 3870
Query: 4360 AEEQQPNIA----------------EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4403
+ +A E LKQ Q + M+ L +EL LLK
Sbjct: 3871 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL-----LLKK 3925
Query: 4404 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4463
+ +++D+ +Q L + + + L + + R+ L AL QF A+
Sbjct: 3926 VTEESDK----------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 3975
Query: 4464 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE 4523
+ + + E + ++ + P + ++ Q + +Q+ V + G +L++
Sbjct: 3976 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4035
Query: 4524 VTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI 4583
+E S + KL+ L + +VL+K R Q+L+ L K F + + WL +
Sbjct: 4036 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095
Query: 4584 VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSE 4643
L QL + + E +L + GQ +L + + + +
Sbjct: 4096 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4155
Query: 4644 KLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD 4703
+N L ++ + ++ K++EA+ E+ + ++ L++ E Q L ++ P+
Sbjct: 4156 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE-QTLNVASRPS- 4213
Query: 4704 LAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ----PDKMLHLVTLY 4759
L ++ L D + +EV E + EL++ + Q + ++ + + +
Sbjct: 4214 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4273
Query: 4760 HRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 4811
++ ++ +R L+D A Q HE K+ + LE KS+ E N+ +T A
Sbjct: 4274 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4333
Query: 4812 EEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK 4866
+ K L HS+ + +G LK T +D K + + +
Sbjct: 4334 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---------KLDDMLSELRDKWD 4384
Query: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG--PVYLDLNLQDIQEEI 4924
+ E + E ++ S F + +DWL RV+ +L+ PV+ D++L + I
Sbjct: 4385 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL--VMNLI 4442
Query: 4925 RKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4984
+ Q+E+ + AL +E +++ S+ ++ + ELS + ++
Sbjct: 4443 DNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKVQMQELSTRWETVCALSISK 4501
Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL-KSHMEFFSTED 5043
Q L Q + ++ V A +WL +A++ L+ G D E A L H EF +
Sbjct: 4502 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4561
Query: 5044 QFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQKVASLELRSQRMSRDSG-- 5090
+ + L + ++ T+ + P + E+ +A + QR++
Sbjct: 4562 EKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL 4621
Query: 5091 -AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEK 5141
A+ +LL+ A QW + K +E + + + + + ++E F T + ++
Sbjct: 4622 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 4681
Query: 5142 LSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGNDASKATLSRSMTTVWQRWT 5193
+K + +S I L++ AS L +G+ T + + + +W
Sbjct: 4682 TKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQ 4741
Query: 5194 RLRAVAQDQEKILEDAVD 5211
++ +A ++ + L DA+D
Sbjct: 4742 QVWLLALERRRKLNDALD 4759
Score = 318 bits (815), Expect = 1e-85
Identities = 900/4830 (18%), Positives = 1875/4830 (38%), Gaps = 684/4830 (14%)
Query: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
V+ W+D M+ L+ +E ++L + L K ++ + + S L+ ++ MT
Sbjct: 282 VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 340
Query: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
L+L ++ +R + AK T + L LH R +WL +++E+
Sbjct: 341 ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 395
Query: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
Y E + + H +R+L + + + Q + +L P+ +
Sbjct: 396 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 452
Query: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
RA + W Q + + E F ++ ++L+ ++ +
Sbjct: 453 YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 504
Query: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
+ R S+ E + + + EE+ Y+ + + +A+ I+ NS + +
Sbjct: 505 KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 564
Query: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
+ Y+ + + + + + + + ++ S +E+ + S +K +
Sbjct: 565 PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 624
Query: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
+A +I++ + + TL + +K + H L+ R ++K + GE
Sbjct: 625 LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 679
Query: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
++ L+ D +E +E + LEK +++ K++ YQE+L
Sbjct: 680 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 726
Query: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
E + E +S+ ++++ + + E ++ +R + E++ + + L
Sbjct: 727 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 786
Query: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
K ++++L+ D + + +E FS A SEL V + + Q MS + D
Sbjct: 787 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 843
Query: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
L+T +L Q A + + EE A D+ NN++ TL Q + K +
Sbjct: 844 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 900
Query: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
Q HA L+ AI + Y+ + + H + D L + W + VQ D
Sbjct: 901 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 955
Query: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
L E I K +K++R ++ V+TT + IQ+ + +T
Sbjct: 956 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1000
Query: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
+ +L Q + L EI+ +S++ + A+Q +K EL+ + MV +
Sbjct: 1001 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1055
Query: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
K + Q+S + II++ L + + + L Q++ S + E+ L+
Sbjct: 1056 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1110
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
+ H V K +W S+ T E K + Q K + E++
Sbjct: 1111 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1157
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
+K+++ E L L K ++ +LE +K T E N++ F E +
Sbjct: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1207
Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
+ +E Q + +++ + Q IC L + LI + M G
Sbjct: 1208 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1264
Query: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
E + Q +++ L K + Q L V + T + + +
Sbjct: 1265 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1306
Query: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
+E L+ +++ C+ Q +LK Q++ +EL K VT E EK
Sbjct: 1307 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1356
Query: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
+ +L+E ++ +++L K S R K ++ + HF+E + D+
Sbjct: 1357 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1416
Query: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
L + D+ N + + A+++ I+ Q ++ + L++ GQ + P
Sbjct: 1417 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1476
Query: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
E L + + L + +A ++ K + +QE + E+ ++ + Q
Sbjct: 1477 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1532
Query: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
L LEA ++ + T L E+ +S + R I + EA +++ G
Sbjct: 1533 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1592
Query: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
T + K+ H + L + + L+D YQ +E L L++ +
Sbjct: 1593 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1652
Query: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
SK E + + K L+ +L G + + LK+ L D L P A
Sbjct: 1653 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 1711
Query: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
+ + G + L+ ++ E + + + +S+ Q + LDW+ V++ L
Sbjct: 1712 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 1771
Query: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
+ LN +Q+ I K + ++++ +NA++ K K+ ++ L+ + +L
Sbjct: 1772 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 1831
Query: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
S + + A + E+ ++ + + + + +LE Q L ++ G DV
Sbjct: 1832 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 1889
Query: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
L +M+ ++E H +LE LHSL+ + P+ K + +K +L + + M
Sbjct: 1890 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 1947
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
+ + + C Q +Q + + + +T KK+ F S E +KL E
Sbjct: 1948 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2007
Query: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
+L +S V + + I A++ + L E T + + ++
Sbjct: 2008 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2067
Query: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
+T++ + T + +D +L+D + E +K++KA E M+ LQ
Sbjct: 2068 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2127
Query: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
+ P + +A K T +E + +F EL+Q + + L+ + +L++ P E P
Sbjct: 2128 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2181
Query: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
Q +T + + + + + +++ + +T +K W+ E + LG
Sbjct: 2182 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2241
Query: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
+I+ ++ Q +++QILL E + E++ + G+ + + SL Q
Sbjct: 2242 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2297
Query: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
LA V + Q+ D+ ++Q+ S Q Q L + L+ L+ L K + +
Sbjct: 2298 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2353
Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
T + ++L+ E+ ++ L + L L++++ + +
Sbjct: 2354 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2413
Query: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
+ ++AEN + L A + ++ +M W++ K N + + +
Sbjct: 2414 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2467
Query: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
+ ++L+++ K+ L A + + + E + + G E L+ + N
Sbjct: 2468 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 2523
Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
K +K+ E +LK+ +LE+A L KEQ+ + L ++ + +
Sbjct: 2524 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 2566
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
+ ++ C E+ +A L LQ+E QH + + +++ +
Sbjct: 2567 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 2617
Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
E E K L Q ++ ++ K N+ QE+ + R + A++ +
Sbjct: 2618 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 2677
Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
+ S K LTM L + LA+ GT D+ ++
Sbjct: 2678 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 2737
Query: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
H ++ +C L + + + T E+ S A S +PV ++ +
Sbjct: 2738 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 2797
Query: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
A+ + L A D A + E P L L L + L +
Sbjct: 2798 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 2856
Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
++ + ++R +++ L+ S I L+ +E E + P E++ Q M
Sbjct: 2857 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 2911
Query: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
++ ++EI LQ L + L+ + ++ + L+ L + R T+ K
Sbjct: 2912 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 2968
Query: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
+ + L+E L L R + AL+ L SW++ T+ + P E ++A
Sbjct: 2969 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3018
Query: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
Q L+D + VE+ KV L +LS+ + L KA
Sbjct: 3019 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3078
Query: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
T++ R+L+G + Q+ H+ + LN T EK + + TQ+ ++E
Sbjct: 3079 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3128
Query: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
+AQ + + K L Q ++ +SL + ++SR ++ ++Q E
Sbjct: 3129 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3183
Query: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
+ + ++L Q L K ED++ M W +H Q++ST+ Q + L
Sbjct: 3184 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3241
Query: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
QE +L + N LL+G+ L K + + L+ + +++++ S +
Sbjct: 3242 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3300
Query: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
Q++ L ++L+ TWLD VE L + L EE + L K+ K
Sbjct: 3301 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3360
Query: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
+D + N S A E G + V ED R L+ + Q+ ++
Sbjct: 3361 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3414
Query: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
+ + + F+Q ++ I + E L +E
Sbjct: 3415 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3448
Query: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
+ +LQV++ E+ + +D+ D+L+ + ++ ++K + ++ L++
Sbjct: 3449 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3508
Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
+ + E+ E Q L+++ E ++ L LTET + IIS
Sbjct: 3509 ICQINSERYL--------QLERAQSLVNQFWETYEELWPW--LTET--QSIIS------- 3549
Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
+L A A LEY ET QQE RQL L+ E
Sbjct: 3550 ----QLPAPA-------------LEY--ETL----RQQQEEHRQLRE---------LIAE 3577
Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
++ + +N+ P+L + L G+ I ++ +Q+ E
Sbjct: 3578 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 3619
Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
+ K L+ + T++ + ++ L+ +RL +Q ++ E+E +++ ++
Sbjct: 3620 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 3674
Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
S +++ L ++ G +++ K + ++ +L ++ W ++ T +
Sbjct: 3675 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 3734
Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
+ KL L + +L + MS I +++ D I + + + +
Sbjct: 3735 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 3791
Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
+ +I+ Q +D V + + S+ + + DK + + +N +W L ++I
Sbjct: 3792 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 3847
Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
LE +++ +Y++ +Q + W + +L IG D +V+ +++ + +
Sbjct: 3848 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 3907
Query: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
++ E+E++ L++ E+ V L EL W +L+ + + L+ L
Sbjct: 3908 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 3967
Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
+ A D++ ++L LS + + G +A+++++ LQ+D+ + +++
Sbjct: 3968 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4027
Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
N L++ L N L+ +N RW N+LE+ ++ Q L+ + K + +
Sbjct: 4028 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4084
Query: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
Q D LL + + A +++ ++ C T K L + G+Q
Sbjct: 4085 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4140
Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
+ + SA + I D +L + ++E L +++T L+ + F SL+ W+
Sbjct: 4141 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4200
Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
+AE+ L S L T+ +++E K + +S + L++ G L +++
Sbjct: 4201 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4259
Query: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
++NL W + + ER L + + F E ME+L ++E+ L +
Sbjct: 4260 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4319
Query: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
EI+ + + Q H+ FQ + ++ + + G+ L E+ + DD + + L+ L
Sbjct: 4320 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4379
Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
++W + ++ +R+ ++ + ++ + + L WL V ++ V +
Sbjct: 4380 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4438
Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
L D K F ++ G +V+A K+ L+ + ++ ++ E+ +W++
Sbjct: 4439 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4494
Query: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
++ +L L+ E+ + LE L ++ L LPD + L + K
Sbjct: 4495 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4554
Query: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
E + +L + + + DT+ A D I+ + + +++ ++EE+ +Q++
Sbjct: 4555 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4614
Query: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
L E + L WL E+ ++ +I + IE++K + + EE+
Sbjct: 4615 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 4674
Query: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
Q + ++ + +R A SH ++IE K +VN
Sbjct: 4675 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 4734
Query: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
+WQ + L R +KL + L +++L
Sbjct: 4735 LLVSKWQQVWLLALERRRKLNDALDRLEEL 4764
Score = 298 bits (763), Expect = 2e-79
Identities = 728/4019 (18%), Positives = 1555/4019 (38%), Gaps = 470/4019 (11%)
Query: 4948 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 782 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 841
Query: 4999 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 5043
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 842 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 901
Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5097
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 902 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 961
Query: 5098 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5155
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 962 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1018
Query: 5156 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5213
K+ ++ A Q T D T++ R+M Q+ + R + + I+++ +D
Sbjct: 1019 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1078
Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
T + V T+ I D L E+ S E + H EL++ S +
Sbjct: 1079 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1131
Query: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5327
+TL + P ++ +EI+ +++ + + K K+ +E + E
Sbjct: 1132 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1191
Query: 5328 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5387
V+T S E+ + L D ++EE + + + +E KEK G
Sbjct: 1192 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1239
Query: 5388 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5430
+ +L + + + + ++LK Q+++++ Q A T L
Sbjct: 1240 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1299
Query: 5431 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
+KL+++ + L + K K + + ++A+ +K L + + + E AAV++
Sbjct: 1300 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1359
Query: 5486 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5539
E ++ L + K +E H+Q I Q + S + E +E+ +
Sbjct: 1360 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1418
Query: 5540 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5596
L+ +V GT N Q ++ H+ ++ + + + + + EK S
Sbjct: 1419 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1475
Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
EK+ + + EL E + +++ ++++KF+A+ + + L+Q++ L
Sbjct: 1476 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1535
Query: 5657 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5705
+ E G LK Q S + ++S L+ + ++ +S + V +
Sbjct: 1536 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1595
Query: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5761
R + A+ + +CN++ + V +Y+ YE L
Sbjct: 1596 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 1644
Query: 5762 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5819
+ +Q +A S+H E +A K Q Q+ + ++ + ++ + V
Sbjct: 1645 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 1692
Query: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5867
+++ AE D G LLP + + GR L V E S ++
Sbjct: 1693 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 1752
Query: 5868 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5919
G N E S + P ++++I Q ++ + +A ++
Sbjct: 1753 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 1810
Query: 5920 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5979
E +P S AK+ DL + + E + E + + +++ + + T +
Sbjct: 1811 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 1870
Query: 5980 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 6039
E L+E PG+ Q E L + + E+ SL +E+ S +D A
Sbjct: 1871 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 1929
Query: 6040 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6089
L + L+ + M TI+ K Q+L + L ++E ++ + +
Sbjct: 1930 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 1989
Query: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
A++L L TK + E + + N++ + A++ +V +
Sbjct: 1990 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2047
Query: 6150 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6206
+L G+ + E A K L +K + ++ D L ++ E S +
Sbjct: 2048 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2107
Query: 6207 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6255
+S + +WL + T T+ +Q+ ++Q K E EL + + ++ + +
Sbjct: 2108 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2167
Query: 6256 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6299
E+L E + D E P D QEL + E+SS
Sbjct: 2168 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2221
Query: 6300 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6337
E+ +++ +++L+ +VL +++Q Q+L Y + G+
Sbjct: 2222 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2281
Query: 6338 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6394
G+ P+ + V L + Q ++ ++ Q Q+I + + + S L
Sbjct: 2282 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2340
Query: 6395 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6454
D++ +L + A+ T NQ++ + + +K + +QA E+ V
Sbjct: 2341 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2396
Query: 6455 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
E+ L L R +L S V Q+ + LQ + + + ++ +K
Sbjct: 2397 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2454
Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6558
P++ +++ ++ K+F + +K E ++
Sbjct: 2455 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2514
Query: 6559 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6617
+L+ ++ +D + R + L ++L +Y+ ++ L ++ Q + + +
Sbjct: 2515 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2574
Query: 6618 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6673
++ E I +L KE Q +L T + + KE T + L+ + V
Sbjct: 2575 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2634
Query: 6674 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6730
++ H + LE + + + E +E RQL+ + + S+G + L T
Sbjct: 2635 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 2690
Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6786
+ Q + SL + ++ + L++ S SD+ Q+ + + + + ++ ++
Sbjct: 2691 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 2750
Query: 6787 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6846
LET L+ +Q+ ++ D L+ V ++ E ++ F
Sbjct: 2751 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 2806
Query: 6847 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
K+++A + + T +L ++ D ++ +L + Q LL A +E++
Sbjct: 2807 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 2866
Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6960
+ +L + S++ + L++ + +E + + I++ L +K F+ + +
Sbjct: 2867 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 2923
Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
KQ V+++ Q ++Q +++ ++ + L +N W+ L V ++ L+
Sbjct: 2924 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 2978
Query: 7021 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
L +++ ++ L +W +T+E Q+ + V+ +++ + L+ L+ ++ VE
Sbjct: 2979 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3038
Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
I++ G + + ++ L L W L + L+ +
Sbjct: 3039 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3098
Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7199
+ +N +L L + ++ Q+ + L+DD+ + L + SI Q LK
Sbjct: 3099 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3157
Query: 7200 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7245
+ + + + + W EI E+ S LLQ +
Sbjct: 3158 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3214
Query: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7300
+ S + Q+ T L K + + +++ Q+ + LL GL +K D +
Sbjct: 3215 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3274
Query: 7301 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7354
+ + E +K + + A ++ L L++ L + + LC ++ +L Y
Sbjct: 3275 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3333
Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
ET ++L+G++ S + Q R +ELK + ++ LD LN
Sbjct: 3334 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3368
Query: 7415 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7468
E+ L P +E K + N + L+S T++ ++ + +L+ Q F + +
Sbjct: 3369 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3428
Query: 7469 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7526
+ ++ +TE+KL +I Q + + F E+ + I+ ++ G +++
Sbjct: 3429 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3488
Query: 7527 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
+++ KL + + + + +R ++ ++ E E+L WL E +
Sbjct: 3489 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3547
Query: 7587 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
+ +P P + TL + + ++ + + +I + LL G
Sbjct: 3548 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3598
Query: 7645 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7701
E IQEK+ +A +++E KK A L + D ++++ +++ + L
Sbjct: 3599 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3657
Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7750
+ AE + KE + + + D+ +L L +TL A D I +
Sbjct: 3658 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 3716
Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7810
++++ + WE + + R ++ + + F + L + + + D
Sbjct: 3717 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 3776
Query: 7811 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
I+ + K +++ +EEI QE + +G L A E ++ + ++N W
Sbjct: 3777 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 3836
Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7924
L R+ KL+E + A Q + ++ W+ +LA PI D E +++
Sbjct: 3837 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 3893
Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
++ E ++ + + + + + + E+LL +++ ++Q L W ++
Sbjct: 3894 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 3950
Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
+ R+ K+E +F WL +E + G + EL K
Sbjct: 3951 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4010
Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
Q V + +E +NK L + + A +L+ + NQRW N+ ++ ++L
Sbjct: 4011 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4070
Query: 8105 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8164
+ Q + F + + WLT+ + L + AK +QL + + K E
Sbjct: 4071 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4129
Query: 8165 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8221
++ +G+Q++ + I+++++ L+ + V E
Sbjct: 4130 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4170
Query: 8222 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
L++R+ +LE++ L+ + +H+ D + Q L+++ L +D+
Sbjct: 4171 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4218
Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD-----HSALESQI 8335
+ + D + ++ S + + D+ G K F + V L + S E +
Sbjct: 4219 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4277
Query: 8336 RQL---GKALDDSRFQIQQ--------TENIIRSKTPTGPELDTS------------YKG 8372
++L G++LDD+R + +Q E + S+ EL+ + +K
Sbjct: 4278 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4337
Query: 8373 YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 8432
+ K LG S D+ R LKE+ + L + + + D+W+ + +++ ++
Sbjct: 4338 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVERQ 4394
Query: 8433 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8492
++++ L QF L ++ WL E +L + Q + DI + I K QK +
Sbjct: 4395 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKEL 4452
Query: 8493 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
R + + ++ + E + +S ++ ++ +++ RW+ VC+L + L+ AL Q
Sbjct: 4453 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4512
Query: 8553 QGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
+ FH + H LL L ++ R + ++P D + L D HK+ M+ +L E + +
Sbjct: 4513 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELN 4568
Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
M +L K + +I R + +L +H + L L ++Q+L
Sbjct: 4569 KATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4627
Score = 290 bits (741), Expect = 6e-77
Identities = 817/4617 (17%), Positives = 1774/4617 (38%), Gaps = 529/4617 (11%)
Query: 1370 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1427
S L S+ S LE K + E E+ +KEA SEI + K ++ ++ Q
Sbjct: 303 SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 358
Query: 1428 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1487
KL +T + ++ + +F S +W+ EKE+E A + S + I++ K
Sbjct: 359 AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 412
Query: 1488 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1541
++E++ K +I ++E A+ Q + AR I+A ++ + + Q
Sbjct: 413 DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 469
Query: 1542 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1596
C+E H+ + + E +++ + K A+ K C ++ +K+ +QE M
Sbjct: 470 CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 525
Query: 1597 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1646
+ + L S I A+ ++ N D ++ + ++ +Q E + + E
Sbjct: 526 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 585
Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1705
A + A W+ + + + + E A+R+ E + Q + L +E
Sbjct: 586 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 643
Query: 1706 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1754
VVS +++ +++ S +VAS +K M + L L R+ D +
Sbjct: 644 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 695
Query: 1755 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1814
+ +S V +L +V K + EL ++E + V + + +EV
Sbjct: 696 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 747
Query: 1815 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1873
+ + L++ + L + + + +DLH + + +L +E ++ + + EF
Sbjct: 748 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 807
Query: 1874 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
A+ S + L + Q + SM+ D + K +N L+N +A E A V L
Sbjct: 808 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 864
Query: 1928 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1984
Y K+ E + + I+NL+ T + SE D + A +
Sbjct: 865 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 907
Query: 1985 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2038
D+ ++ K+I D +T KER KE Q +++ V Q+++ L L
Sbjct: 908 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 959
Query: 2039 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2094
+ K + + P +D I ++E T +R I ENQ + + Q +
Sbjct: 960 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1014
Query: 2095 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
+ SK+ E T+KD E + ++ K K++ + S ++
Sbjct: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1071
Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
E + + +LV T M + D ++LEE L + + E++ W
Sbjct: 1072 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1127
Query: 2214 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2260
+N P + IS+ + + E+L + ++ A +++ + N+
Sbjct: 1128 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1187
Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
L++ K L+ +L F E+ +++L+ ++ +V K K + + ++ + I
Sbjct: 1188 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1244
Query: 2321 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
T+ E L+ + + LKK + Q+ELQ + + + E
Sbjct: 1245 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1304
Query: 2377 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2430
L + LI K +EA QL K + S +E L+K + +++E E K +
Sbjct: 1305 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1363
Query: 2431 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2457
+ S+R G +V+E Q N+L++
Sbjct: 1364 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1423
Query: 2458 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2487
DGQ S+ AV TQ Q L +LS + +Q+
Sbjct: 1424 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1483
Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
+ + ++ L + K + EL F+ + + W+ + E+ ENL
Sbjct: 1484 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1541
Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2605
I ++ + + F S D +S +G L ++ G+ + + CS+
Sbjct: 1542 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1592
Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2661
+ +E R A +L + +K + D+ E L E
Sbjct: 1593 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1652
Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
S+ + ++ + K Q SS + ++ E L + ++ +
Sbjct: 1653 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 1712
Query: 2722 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
Q TL+ ++ ++ D + N+ E + + L Q GL E + +++S L
Sbjct: 1713 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 1769
Query: 2782 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2818
E ++ AL +I+K+ L + +T D S + Q ++K
Sbjct: 1770 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 1829
Query: 2819 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2874
+F++ KE + K+EE+ ++ + + +L + + L D +
Sbjct: 1830 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 1889
Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
+Q E ++ ++ L + SL E+ + S L+ + L +K+ E
Sbjct: 1890 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 1945
Query: 2935 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2973
D++ + + SC E L ++ + + F + L ++LE
Sbjct: 1946 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2003
Query: 2974 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
L + W+ + L+ T + + G +L+ + TE+
Sbjct: 2004 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2062
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+ L +D++ S L L L+ N + Q+ ++ QW
Sbjct: 2063 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2116
Query: 3080 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3136
L +N T + P + V T +++ + F +E + +K+ + K ELL
Sbjct: 2117 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2176
Query: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
+A + +T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 2177 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2236
Query: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3252
D ++Q++Q +L+E +PQ +L Q + S R
Sbjct: 2237 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2296
Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
+++ ++ ++ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++
Sbjct: 2297 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2356
Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3371
++ + + + Q+++ Q+K+ E + E + + +QL+ + +
Sbjct: 2357 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2416
Query: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
+ L+ A + +Q R F W+D+ + N+S A+L +++
Sbjct: 2417 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2476
Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3485
K ++ + + S + E +G + +E QL+L ++ + ++ KE
Sbjct: 2477 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2536
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEG 3545
K ++ + +Y+ ++ W+ + Q L++ A E ++ L+ LQ +
Sbjct: 2537 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQH 2595
Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLR 3601
++ + +T ++ + + + + +SL Q +L + N+ K +
Sbjct: 2596 FGMVELLNNTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2653
Query: 3602 LMEQKFQQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEE 3657
++ ++ L+ A+E++ S ++ SN+ +Q Q + + A + +V+
Sbjct: 2654 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDL 2708
Query: 3658 VGARAQEILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
AQ+++ E S S + Q + + L QV E+ FLE ++Q + ++++
Sbjct: 2709 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 2768
Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
+ ++A +T+ K+ +T++ LK +E L ++ + +
Sbjct: 2769 REMFSQFAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKT 2822
Query: 3775 VKYLEEGEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
K + E +++++ +Q +L + +E + +EF K K +
Sbjct: 2823 CKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 2882
Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQ 3888
+ + +E ME QL+ +K Q+ + + + V G+ L++
Sbjct: 2883 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 2942
Query: 3889 DVT----LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
T L+ +D + + ++ L + L+ + + L+ + W++
Sbjct: 2943 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-E 3001
Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
LVA ++ + + Q+ K + + + + ++ +G+ + A + K
Sbjct: 3002 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKV 3057
Query: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
+ L + A+ + A+ + LE +TL+ WL+ ++ L
Sbjct: 3058 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3117
Query: 4065 PPLSRAEAIKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNA 4102
++ +Q+ +AL++ +R D++ S D S
Sbjct: 3118 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQV 3177
Query: 4103 SVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRR 4159
+ + ++Q L A+ + E+ + +E+ L D + + ++
Sbjct: 3178 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3237
Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
SEL V Q ++K QA +N + E + + T E ++ + ++
Sbjct: 3238 QSELR-------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYK 3289
Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVH 4274
D+ + S ++ E+ LQ R H C + +V +E + E L +A +
Sbjct: 3290 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3349
Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
+ LKK A + K ++ L + ++E + +E +++ + +R+ + D I +
Sbjct: 3350 PKELKKEA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3406
Query: 4335 KIQ-VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
K++ + L Q+ EL W E + + D L E
Sbjct: 3407 KVEEIDAAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3465
Query: 4394 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4453
+ + ++ L+K ++M E+Q ++K L + + + + +R L +A S
Sbjct: 3466 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3525
Query: 4454 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4513
QF + + + + I L + + +Q + + + + ++ + +
Sbjct: 3526 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3585
Query: 4514 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4573
G +L+ E++ E + K ++Y + + R L++ + F + D+
Sbjct: 3586 NKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3644
Query: 4574 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
L++ ++ E ++ Q+++ +N+ + + L TL++ G+ ++
Sbjct: 3645 ILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 3704
Query: 4634 NEVDHSY----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLS 4688
D + +KL+ + + I L +++ K+ + + LA K + + L ++
Sbjct: 3705 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIK 3763
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPW 4747
+ + F+R + P + Q+ I +E+ GL E +D +N E + G+P
Sbjct: 3764 DTQ-DFIRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD 3821
Query: 4748 QP---DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
+P + L + + L + + R+ LE+ A +++ Q + + + + +
Sbjct: 3822 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 3881
Query: 4805 NE-----ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQI 4858
+ ET+ + E+LK + S A Q I ++R+ E L L + E +H +
Sbjct: 3882 SPIGTDLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTV 3935
Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLD 4914
Q ELKL+ ++ E + + ++ ++ FQ + L WL + LS +
Sbjct: 3936 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 3995
Query: 4915 LNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD 4974
+ + I+ E+ K + Q +V + + A++ + + +++L++ L L++
Sbjct: 3996 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4055
Query: 4975 GDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENL 5032
++ E R+ L Q + ++ + WL D + L LA L E+A+E L
Sbjct: 4056 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQL 4114
Query: 5033 KSHME----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
HME F + E+ + S +++ ++A + + +++Q + +L+ + + +
Sbjct: 4115 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETK 4170
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEH 5145
+ L+ ++ + ++ I + E+ L S SL+ + + + EH
Sbjct: 4171 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEH 4226
Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
K + VNS E+I+ L++ + L+ + + +V RW ++ ++ +
Sbjct: 4227 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4286
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
L+DA F+ K E +++ + L ++ T L H F L +
Sbjct: 4287 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4346
Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKD 5324
S + S+ E+ L + + D +++K T GK V+++ K
Sbjct: 4347 SVYDTTNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKL 4397
Query: 5325 REMV------ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKM 5377
E + + ++ W+ Y P + D + ++ +++ NH+
Sbjct: 4398 EEALLFSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK------ 4446
Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
+K LG T S+Q AL R+ I+ + K QELS + + +
Sbjct: 4447 ---AFQKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4494
Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
+ T+L+A EE L+E A ++ L +G L
Sbjct: 4495 CALSISKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD- 4542
Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHG 5552
+ L + H++ +++ E + ++LN+A + + + + + I WI +
Sbjct: 4543 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 4602
Query: 5553 TIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRE 5612
+AW Q R L + ++ LEA+ LQ+ + T+K + + + E
Sbjct: 4603 VLAWAKQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---E 4653
Query: 5613 TEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
EE++ +I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 4654 IEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 4710
Score = 235 bits (599), Expect = 2e-60
Identities = 796/4534 (17%), Positives = 1666/4534 (36%), Gaps = 676/4534 (14%)
Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 265 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 320
Query: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 321 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 366
Query: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 367 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 421
Query: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 422 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 472
Query: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 473 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531
Query: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
+S + + + +T+ + +I ++ AN
Sbjct: 532 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 591
Query: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
+A K C ++ E Q++ L LW HE
Sbjct: 592 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 650
Query: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 651 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 704
Query: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 705 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 757
Query: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 758 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 816
Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 817 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 871
Query: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 872 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 927
Query: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 928 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 987
Query: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 988 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1045
Query: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 1046 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1091
Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
+ D+L++ E + L+ + E +++L + +S
Sbjct: 1092 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1132
Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 1133 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1186
Query: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 1187 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1246
Query: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 1247 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1306
Query: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 1307 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1361
Query: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 1362 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1421
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 1422 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1478
Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 1479 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1538
Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
++ T L + K +E+V+S+ L I + G + E
Sbjct: 1539 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1598
Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 1599 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1658
Query: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
+ + D + L + + LQ + Q + + T E D S +P
Sbjct: 1659 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 1713
Query: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
D + L+ + ++ ++E + + + ++ ++ +W+ E + + +
Sbjct: 1714 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 1773
Query: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
N + + + +++ + + + + ++ ++ + ++ QA L++
Sbjct: 1774 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 1833
Query: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
R+ + L +++ L+ +++ E L ++ + + ++
Sbjct: 1834 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 1893
Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
M + LE K +E HSLLK G + K L + L K + KE+
Sbjct: 1894 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 1945
Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
T++++ + F K+L WI E + + + +P + L K
Sbjct: 1946 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2004
Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
LQ+ P ++ V G +L L+ VT
Sbjct: 2005 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2064
Query: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
+K + + Y+DL + K+ + L K+ + E + +WL +M+
Sbjct: 2065 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2124
Query: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
P +T +++T +Q K
Sbjct: 2125 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2184
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
M+ EI LN L + + + +++L +A+LKQ + + G
Sbjct: 2185 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2244
Query: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
+ +T ++ Q L LQ+ +R+ +Q A A Q L + P R +Q+
Sbjct: 2245 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2298
Query: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
A+ ++ + L CD + A VK+T Q +++ KL N +
Sbjct: 2299 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2353
Query: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
+ L+ A + Q +++ +++ +AQ + + VK+ + +A ++ +E
Sbjct: 2354 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2410
Query: 4196 VNKLTKKEESPEHKEINHLN----------------DQWLDLCRQSNN------------ 4227
+ K K E + HL WLD ++ N
Sbjct: 2411 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL 2470
Query: 4228 -LCLQREEDLQRTRDYHDCM--------------------NVVEVFLEKFTTEWDNLARS 4266
++ +D +T M +++ L T WD +
Sbjct: 2471 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2530
Query: 4267 DAESTAVHLEALKK--------------------------LALALQERKYAIEDLKDQKQ 4300
E E+L+K L E + +I LK ++
Sbjct: 2531 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK 2590
Query: 4301 KMIEHLNLDDK------------ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4348
+M +H + + E+ KE + + Q D++ ++ LE +
Sbjct: 2591 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT- 2649
Query: 4349 VQSRFQELMEWAEEQQPNIAEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIK 4406
+F+E E ++E + + A +Q D +Q +L + + LK +
Sbjct: 2650 --QKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 2707
Query: 4407 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4466
A R+ DL V++ + S S V + + Q L++ + EK FL Q
Sbjct: 2708 LAKRLAQDL------VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 2761
Query: 4467 SQIQQHERKI--MFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMK 4522
Q R++ F E L V + +T + + ++K + ++ L A K
Sbjct: 2762 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 2821
Query: 4523 E-----VTEQEKSEVLG---KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4574
TE+ +++G L+ L + +L + R +++E + + F +
Sbjct: 2822 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 2881
Query: 4575 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILP 4631
L++A+ + + E+ ++ QL ++ + Q E E L Q GQ ++
Sbjct: 2882 SILLQKAEEHEESQGPVGMETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQ 2939
Query: 4632 S-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4690
S L L+ + ++ + + ++QEA+L + +E + +
Sbjct: 2940 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 2999
Query: 4691 EAQFLRMSKVPTDLAVEEA-LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQP 4749
E + V +A + Q + +LD+ V+ + ++ E +T +P
Sbjct: 3000 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADK 3056
Query: 4750 DKMLHLVTL----YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4805
K+L ++L + L + E R LE + Q+ + + L L ++ E+ VN
Sbjct: 3057 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVN 3114
Query: 4806 EETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS---- 4860
E + + KL+ + +L+D I + + L L+ + + +QS
Sbjct: 3115 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3174
Query: 4861 ---WQGELKLLTSAIGETVTE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL 4915
W E++ + + E + + C +++ F + ++WL V +LS D
Sbjct: 3175 SQVWYIEIQEKSHSRSELLQQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDY 3229
Query: 4916 NLQDIQEEIRKIQIHQEEVQSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELS 4971
+ + + ++ ++++ QE++ LR N L+ E K T E++ ++ L +
Sbjct: 3230 STEGLWKQQSELRVLQEDI--LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIK 3285
Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEE 5030
DI + TL + +R + + WL+ + ELL L E A +
Sbjct: 3286 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3345
Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSG 5090
E + L+ L+ + + L L+ +E LE+ VA R + +S
Sbjct: 3346 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3405
Query: 5091 AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
+V+ + + + +A + + + +TEKKL ++ + +L K
Sbjct: 3406 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTM 3464
Query: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
+ + I L + ++ ++ K ++ + + V + + + + ++ LE A
Sbjct: 3465 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3524
Query: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
F ++ + + Q + A L E H + + + +
Sbjct: 3525 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3584
Query: 5271 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5330
+ + +L+ +PGE + ++ A ++E VK + + +
Sbjct: 3585 MNKTGPQLLE----LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3640
Query: 5331 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEK 5384
+I+ + ++ E L P I A++E+++ ++E N ++EK+ +++ E+
Sbjct: 3641 KIDQILESLERIVERLRQPP-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEE 3699
Query: 5385 YLGLYTILPSELSLQLAEVALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
+ ++S + + LD + I + I ++E E EL+ +K D
Sbjct: 3700 MIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHM 3756
Query: 5443 TILTKLKAKTD-------------NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ 5489
+++ +K D V Q + + + EE+DG +L + + +
Sbjct: 3757 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 3816
Query: 5490 NGQLGKPLAKK-IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 5548
G+ KP+ KK I +L + ++R+ KL +A +Y + L+ + W++
Sbjct: 3817 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD---- 3872
Query: 5549 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
+A G +A S S + + +EE K+ S EA ++++ E+++ Q
Sbjct: 3873 IAGGKLA--SMSPIGTDLETVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAEL 3921
Query: 5609 LGRETEELRQMIKIRLQNLQDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L ++ E + +QD ++K E + Q LE A L +
Sbjct: 3922 LLKKVTE-----ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 3976
Query: 5665 LKEQLSHRQHLLSEMESL--KPKVQAVQLCQSALRIPEDVVASLPLCHAALR-------- 5714
L L+H + LLSE + + PK ++L + + + DV+A A +
Sbjct: 3977 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIES 4035
Query: 5715 -LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------- 5763
EEAS LQ+ Q + + EQ +Q++ + +G H EIED
Sbjct: 4036 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095
Query: 5764 -----KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
KP+ + + Q++ H E+ + +E SL K + + + +
Sbjct: 4096 HLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4154
Query: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
++ L E E ++ +L + + + ++L + + E T + S
Sbjct: 4155 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS---- 4210
Query: 5879 CRSPSPVANTDA-SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 5937
PS + +T +++ + +++ R Q ++ + + + F + L
Sbjct: 4211 --RPSLILDTVLFQIDEHKVFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLL 4266
Query: 5938 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5997
+Q WE + + E+ R+L +A +R +++ ++ + +E E L E P+
Sbjct: 4267 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPD 4326
Query: 5998 ---SQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
+Q+A+H+ + L + + + + L ++ AD + L L L+ L ++
Sbjct: 4327 KIKTQLAQHKE-FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKW 4383
Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
TI K+ ++ LEE L L + ALQ L WL + L P
Sbjct: 4384 DTICGKSVERQNKLEEAL---LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVH 4432
Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
+D+ L+D + K + + + L+EG ++D++ + +++ L
Sbjct: 4433 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELST 4489
Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQ 6225
+ KQ ++ ++ EE + A + EWLA+A T
Sbjct: 4490 RWETVCALSISKQTRLEAALRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDED 4544
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
++ + Q KE ++L E+++ L + G+ +L
Sbjct: 4545 ALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4578
Score = 224 bits (570), Expect = 4e-57
Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)
Query: 500 LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 551
L+K + EL +L L E S + W+ K + + Q + + +E +K
Sbjct: 2088 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2147
Query: 552 FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
FE Q Q LK ++ + EA + + E ++W+ L+ +
Sbjct: 2148 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2207
Query: 608 LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 654
LEE +N ++ A L+ WL + E MLN + +
Sbjct: 2208 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2267
Query: 655 QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 711
Q+ + AG ++ D + +K+QL + +W L ++ D+
Sbjct: 2268 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2327
Query: 712 EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 761
+Y + +LS ++ KLS L VS MN +L + Q+++ ++++ V A
Sbjct: 2328 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2387
Query: 762 --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 814
+ K +L + S Q EG K K + + ++ C S ++ S+
Sbjct: 2388 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2447
Query: 815 IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 871
L+ +++ + K++ + +++ + + S L Q H ++ +A EN L L
Sbjct: 2448 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2503
Query: 872 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 931
+GS+ + L+ + ++D +Q+ + + ++K +K+ VET + K
Sbjct: 2504 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2561
Query: 932 FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 989
+ + E++ L A EG + L + + F ++ N+ L C+ +++
Sbjct: 2562 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2620
Query: 990 PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1046
++ + +Q+ +LH + L+ ++ E R L +E +LD
Sbjct: 2621 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 2677
Query: 1047 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1106
L Q S K + + + + + ++ L + L L V D+ GT V L+
Sbjct: 2678 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 2732
Query: 1107 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1164
E A ST + +++ + + + F + I +Q E A G
Sbjct: 2733 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 2792
Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
++ K+ ET+ +L+ L ++S + A K + + LV + ++
Sbjct: 2793 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 2843
Query: 1225 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1265
E K + D Q +E +K LEE S KE + Q ++T
Sbjct: 2844 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 2902
Query: 1266 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1321
E + + + + +++ + + K++DV Q + Q+ H +L + +
Sbjct: 2903 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 2961
Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1379
L + ++ ++Q L RF+ E+++ ++ T ++++ S + + + +++
Sbjct: 2962 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3020
Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1437
++ K + + E + +E +I P +K + +Q + + + L + E
Sbjct: 3021 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3080
Query: 1438 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1494
+ +E + F E L+ W+T EK L + T +S ++ QI+Q K +I
Sbjct: 3081 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3140
Query: 1495 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1554
+ + QS + + +++KL + + E++E + + L
Sbjct: 3141 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3200
Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1607
+ F E+ ++ ++E DKL+ + + +TE +VLQE D+ +++
Sbjct: 3201 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3257
Query: 1608 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1665
A+ ++ + + + A++ +Y+DI + + + LE L +RL
Sbjct: 3258 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3317
Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
TWL++ E + S E + + +++ + L+ E + + L ++ +L
Sbjct: 3318 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3376
Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
+ + ++ + + +ER+R + I +++ + + + QQFD+ + WI
Sbjct: 3377 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3436
Query: 1786 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
+L + +I + Q + L K E+ K + L K+ + E+ ++
Sbjct: 3437 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3496
Query: 1844 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
K + + ++ Q+ R L L S + +F +++ L L + Q++ +
Sbjct: 3497 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3555
Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1957
E + + + + Q + + +D + L++ E AD L
Sbjct: 3556 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3615
Query: 1958 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2017
+++ EA + + F D+ +++L+S+E I ER + + ++++
Sbjct: 3616 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3672
Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2071
+ + ++ + LK + +++ KD++ A V +++++ W++
Sbjct: 3673 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 3731
Query: 2072 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2121
L+ E + + +++L ++ ++ S ++ + T I+D ED +
Sbjct: 3732 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 3782
Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2177
K ET + +++ Q++LD + G L++ K I + + +S
Sbjct: 3783 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 3842
Query: 2178 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2237
W D +KLEE M + ++ D + + D ++ + + M+ ++L+ + E L
Sbjct: 3843 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 3898
Query: 2238 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2294
K+F+SE + + +E L+ + + L K + D ++ LM+ KL + +E
Sbjct: 3899 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 3955
Query: 2295 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2349
+ L+ Q + ++++ W T E L + E L K +Q ++
Sbjct: 3956 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4015
Query: 2350 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2408
+ QS + + + N L E +L + L ++ + V + + + L +L
Sbjct: 4016 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4075
Query: 2409 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
K F +++ Q+W + S G + + +L+ + + + ++
Sbjct: 4076 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4135
Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
Q+GQ + A K ++I + I E++++ + + K L++ + F + +
Sbjct: 4136 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4195
Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
W+ + E+ N + + + HKV F E+ + RE + +L + G L +
Sbjct: 4196 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4251
Query: 2588 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2643
Q+ L LL S Q+ +++ E+ RS A + + EA + W++
Sbjct: 4252 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4311
Query: 2644 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2702
+ L D ++ +L+Q ++ G + G ++S +
Sbjct: 4312 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4371
Query: 2703 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2762
+ L L++ W I SV Q+ LE + + + L W+ V+ ++
Sbjct: 4372 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4431
Query: 2763 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2821
+ L+D+ ++ E T ++ L +REL E +D S+ +EL T++
Sbjct: 4432 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4491
Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
+ ++ K ++E ++ + VH +WL A++ L + D A + +
Sbjct: 4492 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4551
Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
+ KE + E + L++ ++ V + + +RA ++E+ + +
Sbjct: 4552 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4608
Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
+ L S +A G +A+ ++ LE A L+ WA+ T L K D+E++
Sbjct: 4609 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 4651
Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
QEI E++K+ + E F +++ V + K Y
Sbjct: 4652 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 4685
Score = 162 bits (411), Expect = 1e-38
Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)
Query: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 683 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 740
Query: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 741 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 800
Query: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 801 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 845
Query: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 846 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 896
Query: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 897 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956
Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 957 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1016
Query: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 1017 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1076
Query: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 1077 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1136
Query: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
EK + S QK S KE +T L +K +
Sbjct: 1137 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1196
Query: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1256
Query: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 1257 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1310
Query: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 1311 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1370
Query: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
W+ ++ + H + T
Sbjct: 1371 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1430
Query: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 1431 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1490
Query: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 1491 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1550
Query: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 1551 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1610
Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 1611 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 1669
Query: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 1670 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 1726
Query: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 1727 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 1786
Query: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 1787 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 1846
Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 1847 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 1901
Query: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 1902 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 1960
Query: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 1961 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2018
Query: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
+ S+ NL + A A T+ E SI++ ++
Sbjct: 2019 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2078
Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 2079 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2138
Query: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 2139 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2198
Query: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 2199 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2258
Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 2259 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2318
Query: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 2319 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2374
Query: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
V E DLS ++ +A S EG + KD + +
Sbjct: 2375 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2429
Query: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
SA S Q +Q+ + A D++ + Q + I +K L +K + K L S
Sbjct: 2430 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2489
Query: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
+ ++ E+ L + + S + L +T W+ Q +E ++K++L+K
Sbjct: 2490 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 2544
Query: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
++ + ++W W+ + LE+ ++ D E I KLK LQK +D ++
Sbjct: 2545 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2601
Query: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
+N + + + D + + D V L + L++ + + F E+S
Sbjct: 2602 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2661
Query: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
L E +D + SN +LQ K L +KH++ L QD+
Sbjct: 2662 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 2718
Query: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
+ +++GT + +V I L ++V LE KL + Q + S
Sbjct: 2719 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 2775
Query: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
DELD+ V GR QK
Sbjct: 2776 AEFDDELDSMAPV----GRDAETLQK 2797
Score = 96.3 bits (238), Expect = 1e-18
Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)
Query: 6806 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 284 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 336
Query: 6863 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6922
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 337 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 388
Query: 6923 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 389 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 440
Query: 6983 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 7041
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 441 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 498
Query: 7042 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7099
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 499 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 551
Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7154
+T + + +I + D +SH+ + I+ EA
Sbjct: 552 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 611
Query: 7155 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 612 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 671
Query: 7209 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7253
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 672 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 731
Query: 7254 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7293
Q++ EDR ++ +D + V I + L K L
Sbjct: 732 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 790
Query: 7294 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 791 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 847
Query: 7354 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7407
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 848 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 907
Query: 7408 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7456
+L + + + KE ++ L W + Q R L+ L
Sbjct: 908 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 967
Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 968 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1023
Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1024 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1068
Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
+ E L V + Q + D ++ E+
Sbjct: 1069 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1104
Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7692
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1105 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1158
Query: 7693 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7750
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1159 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1206
Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7806
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1207 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1258
Query: 7807 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7852
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1259 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1318
Query: 7853 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7905
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1319 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1378
Query: 7906 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7930
SE A K ++ S EE Q LN+Q
Sbjct: 1379 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1438
Query: 7931 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7985
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1439 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1497
Query: 7986 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 1498 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1556
Query: 8045 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8092
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 1557 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1616
Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8146
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 1617 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 1674
Query: 8147 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8204
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 1675 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 1734
Query: 8205 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 8260
++KL ++ L R L ++D L W SL P S+ L
Sbjct: 1735 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 1784
Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 8319
+++ + E+ +S+++ ++ ++ M PS Q KD R
Sbjct: 1785 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 1834
Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
+ S H +++ +L ++ ++ + + +KT E+D K +L
Sbjct: 1835 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 1893
Query: 8380 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
S LEHK E SL ++ H + A V+++ L + E +K+
Sbjct: 1894 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 1951
Query: 8439 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 8475
++ F + S+ +W+ +T ++ LE ++L+ +
Sbjct: 1952 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2011
Query: 8476 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 8520
+T E+Q L L AV I ++ + + E T +++E +
Sbjct: 2012 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2071
Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
+ ++ ++ ++ + LL++ L L + Q E S ++ L+ +++ +
Sbjct: 2072 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2131
Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
+ D E ++ +Q + EL ++ +V L+D +LL E D EA
Sbjct: 2132 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2181
Query: 8641 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 8685
R K +L E+ +EL +L L+ SS+ + L W EL S +
Sbjct: 2182 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2240
Query: 8686 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 8745
P S PN T R + + + P LS PG S RG + L
Sbjct: 2241 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2298
Query: 8746 RA 8747
A
Sbjct: 2299 AA 2300
Score = 54.7 bits (130), Expect = 4e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 366 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 4274 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4322
Query: 425 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 4323 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4366
Query: 479 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 4367 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4426
Query: 525 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 4427 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4481
Query: 585 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 4482 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4541
Query: 639 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 4542 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4601
Query: 692 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 4602 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4661
Query: 747 QD----LEDIEQRVPVMDAQYKIITKT 769
+ +E++ ++ P +D +TKT
Sbjct: 4662 AEHQTFMEEMTRKQPDVDK----VTKT 4684
Score = 33.9 bits (76), Expect = 7.3
Identities = 90/474 (18%), Positives = 181/474 (38%), Gaps = 61/474 (12%)
Query: 8169 QGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 8228
Q +QL+++ A + +E+ LR C V+ + + +L + L+ +
Sbjct: 132 QADQLVQR-----VAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ 186
Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
+ S L SL SS+++ L+ + S + TPA P
Sbjct: 187 TLHPSLTSGL------TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS----- 235
Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG--DHSALESQI-----RQLGKA 8341
L + S + E Q K +R + S D + E +I + L
Sbjct: 236 -GLVPNFSSGV------EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 288
Query: 8342 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
+D+ + Q+ +TE S P+ ++K + + E SS+ E K+ E + +
Sbjct: 289 VDEMQVQLDRTE--WGSDLPSVESHLENHKNVHRAIEEFESSLK-----EAKISEIQMTA 341
Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8461
P + A + R E A+ L+ +++L F S + WL + EE
Sbjct: 342 P-------LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
Query: 8462 ELEQLQRLELSTDIQTIELQIKKLK----ELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
E E++ D I + K EL + +D ++ I S+ + + +
Sbjct: 395 E-------EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPAR 447
Query: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHG--LLLMLENIDRRKNE 8575
++ + M +W + L + +++ + F++ L L++ +RK
Sbjct: 448 LTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK-- 505
Query: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDC 8628
D + L+D ++ M+ K ELL+ + +A+L + ++ + +DC
Sbjct: 506 -YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 558
Score = 33.5 bits (75), Expect = 9.6
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 375 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 4367 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4426
Query: 427 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 4427 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4485
Query: 484 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 4486 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4545
Query: 536 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 4546 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4589
Query: 592 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 4590 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4632
Query: 652 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 4633 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 4683
Query: 712 EY 713
Y
Sbjct: 4684 TY 4685
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 354 bits (909), Expect = 2e-96
Identities = 725/4074 (17%), Positives = 1609/4074 (39%), Gaps = 457/4074 (11%)
Query: 1895 NSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQ 1954
N++ E + ++DL Q L++ ++ D L ++ SS + R+ +
Sbjct: 1087 NALRIAEQEHTQEDLQ---QLRSDLDAVSMKCDSFLHQSP------SSSSVPTLRSELNL 1137
Query: 1955 LCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQAL 2014
L +++ + L ++ + V+ ++ QD ELL ++ E + +E + AL
Sbjct: 1138 LVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDA--ELL--VKGYEIKLSQEEVVLADLSAL 1193
Query: 2015 QQRLRVFNQLEDELNSHEHELCWLKD---KAKQIAQKDVAFAPEVDREINR-------LE 2064
+ ++ L + KAK +A++ PE + ++ R L+
Sbjct: 1194 EAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ 1253
Query: 2065 VTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWA 2124
W + Q + + +++ +Y+ + K +E T QE +K
Sbjct: 1254 ERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEE---------TTAQQEMMKPG 1304
Query: 2125 FSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK 2184
++ ++ +Q L + + L + +K S +S + D E + + E
Sbjct: 1305 QAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKF-SQQYSTIVKDYELQLMTYKAFVES 1363
Query: 2185 LEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRA-EELLKEFESE 2243
+++ + R LS D + ++ V +++ + + LR EE K E E
Sbjct: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEE 1423
Query: 2244 VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFT 2303
+ +++EL V+ L T+ T + KE T++ K L+
Sbjct: 1424 KQEHVEKVKELLGWVSTLARNTQGKATSSE--------------TKESTDIEKAILEQ-- 1467
Query: 2304 AQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL 2363
+ ++TT +V E++ + K K + ++ IS E L
Sbjct: 1468 ------QVLSEELTTKKEQVSEAIKT-------SQIFLAKHGHKLSEKEKKQIS---EQL 1511
Query: 2364 NSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFL 2423
N+L + YH S + + SQL +T+ + + + +++ W
Sbjct: 1512 NALNKAYHDLCDGSANQLQ-------QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVG 1564
Query: 2424 GAKAAAKESSDRTG--DSKVLEAKLHDLQNILDSVSDGQSKLDAVT-------QEGQTLY 2474
A+ A RT D L+ DL+++ D + + + V +E QT
Sbjct: 1565 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQT-- 1622
Query: 2475 AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEM 2534
LS + +++++E++ +A E+++A ++ ++ L++ + E + K
Sbjct: 1623 -KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKA------- 1674
Query: 2535 EERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLS----QRGQLLSEEGH- 2589
+ L E+K+ I + V V G+LL +++LS ++G L + +G+
Sbjct: 1675 -----AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
Query: 2590 GAGQE----GRLCSQLLTSHQNLLRMTKEKL---RSCQVALQEH------EALEEALQSM 2636
G Q + C + HQ LL + + +S Q L +H E + Q +
Sbjct: 1730 GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKL 1789
Query: 2637 WFWVKAIQDRLACAESTLGSKDTLEKRLSQ-IQDIL------------------------ 2671
+ LA +E+ L TL+ L + +QD
Sbjct: 1790 GELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPE 1849
Query: 2672 ----LMKGEGEVKLNMAIGKGEQA-----------LRSSNKEGQR------VIQTQLETL 2710
L+K +G ++ KG+ + +S KEG+ +++ +L+
Sbjct: 1850 TLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDA 1909
Query: 2711 KEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP----QPG- 2765
E + + S S L ++ Q++ + + L+ WM++ + +E L PG
Sbjct: 1910 TERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGV 1969
Query: 2766 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY-EKTEDESFKDTAQEELKTQFNDI 2824
L+E+ LQ L+E + L ++ E+ E D + + + F +
Sbjct: 1970 LQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSL 2029
Query: 2825 MTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS--- 2881
E+ +++ + +++ + ++ L S S Q+ L+
Sbjct: 2030 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM 2089
Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
K+K+ I ++ + + E +TTA+ +Q A+ Q + + Q
Sbjct: 2090 KLKQDIARQKSSLEATREMVTRFMETADSTTAA-------VLQGKLAEVSQRFEQLCLQQ 2142
Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
E+ + ++ + F +L+Q +E S +L + G D++I + +
Sbjct: 2143 QEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS---------GNQPDQDITHFFQQ 2193
Query: 3002 GQEILDALQKAEPRTEDLKSQLNEL--CRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQ 3059
QE+ ++ + + L+ + EL C F+ DL + +V L K++ L + +
Sbjct: 2194 IQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK 2253
Query: 3060 NKEQILQQ--RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENG 3117
+ +Q FRK R FQ+WL + + + + E+ ++ ++ L + +
Sbjct: 2254 DASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASK 2312
Query: 3118 QHKLNMMLSKGELLSTLLTKEKAKGIQAK-------VTAAKEDWKNFHSN---------- 3160
+ + KG L L+ + A Q K V ++ +H+
Sbjct: 2313 GTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDM 2372
Query: 3161 -------------LHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLP 3207
LH+++ +L+ + +M++ A + WL E+++ S P
Sbjct: 2373 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL--KSMDAMSSP 2430
Query: 3208 AK----RREQQKLQSVLEEIHCYEPQLNRLKEKAQQL---WEGQAASKSFRHRVSQLSSQ 3260
K + + + ++ L E+ P++ ++KE L + +++++ +L+S+
Sbjct: 2431 TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSR 2490
Query: 3261 YLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRT 3320
+ + +T + +L+ + F +L+ W+ + M+ + D ++L+++
Sbjct: 2491 WERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQK 2550
Query: 3321 LKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT--IQQQLQSVKDMWASLLSAGI 3378
+++ +L + + Q + + + +L + T +Q++LQS+ W L
Sbjct: 2551 QQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLN 2610
Query: 3379 RCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN-------ESERQHAELRDKTTMLGK 3431
SQ++ A+ K T YQ+ ++ S + ++ L+ + E +L + + +
Sbjct: 2611 SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD 2670
Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGMTEHYVT---QLELQDLQERYRAIQERAKEAVTKSE 3488
+ L+ EV +L + + V + E Y+ + L+ + + +++ A + + + +
Sbjct: 2671 LEQLDHEVKEAQTLCDELSVL---IGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQ 2727
Query: 3489 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL 3548
+ Q++Q+ WL +Q + + + ++ L++ +E Q +
Sbjct: 2728 AALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGS 2787
Query: 3549 LNSVLHTREDVIPSGIPQAEDRALES----LRQDWQAYQHRLSETRTQFNNVVNKLRLME 3604
++ E ++ S P E R L++ L+ W+ + ++ +++ + + K + +
Sbjct: 2788 YEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQ 2847
Query: 3605 QKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQE 3664
+ + W++ + K+S R + E L + K EV R +E + + A
Sbjct: 2848 WHVEDLVPWIEDCKAKMS-ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 2906
Query: 3665 ILDESHVNSR-MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3723
+++ S + + + + A+ + L+ + SLEE L + + + +
Sbjct: 2907 LINSSEADEDGIRDEKAGINQNMDAVTEE-------LQAKTGSLEEMTQRLREFQESFKN 2959
Query: 3724 THKNFKNVATKIDKVDTV----MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLE 3779
K + +++ D + K L+ L + ++ + R + V+
Sbjct: 2960 IEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAP 3019
Query: 3780 EG-EAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEI 3838
+G +A +L + ++ E+ V + +E L +F + + + +A+ +
Sbjct: 3020 DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDE 3079
Query: 3839 L-------HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT 3891
L + + ++ + + L+K L+ + + E + + E+ E L+L+
Sbjct: 3080 LDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EGTLDLLG--- 3135
Query: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951
LK +++ L L GK LE + ED+ +L+ + + A +
Sbjct: 3136 LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND-ATTAAEEAEALQWV 3194
Query: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQ 4011
+ +E I QQLA K +E +++ LQMK + G +Q+ K L+
Sbjct: 3195 VGTEVEIINQQLADFKMFQKE------QVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE 3248
Query: 4012 GTKDSYSAICST-----AQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPP 4066
+ +A +T AQR+ Q L+ L QD L+ +WL+ + +L + +PP
Sbjct: 3249 HDMEEINARWNTLNKKVAQRIAQ-LQEALLHCGKFQDALEPLLSWLADTE-ELIANQKPP 3306
Query: 4067 LSRAEAIK-QVKHFRALQ---EQARTYLDLL----------CSMCDLSNASVKTTAKDIQ 4112
+ + +K Q++ + LQ + + +D+L + D + + + + +
Sbjct: 3307 SAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESR 3366
Query: 4113 QTE---------QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ------QLQNMK 4157
TE + +E LV A+ + E I S L +++ ++Q
Sbjct: 3367 WTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI 3426
Query: 4158 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4217
RH LE +I +N + V VK QS + + + V L++K +S + + + + D+
Sbjct: 3427 IRHKALEEDI-ENHATDVHQAVKIGQSLSSLTSPAEQGV--LSEKIDSLQAR-YSEIQDR 3482
Query: 4218 WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEA 4277
CR++ L ++ L R + + V +L + + ++ D + +H +
Sbjct: 3483 ---CCRKAALL----DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQH 3535
Query: 4278 LKKLAL--ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRK 4335
LAL + RK ++ Q +++ ++ L++E+ ++ R+ + +
Sbjct: 3536 ADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKA 3595
Query: 4336 IQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELE 4395
++ + QS ++EL W E + +A + QSP + + E+
Sbjct: 3596 LRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 3655
Query: 4396 AKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEK 4455
+++L ++ + + ++ + R+ + K +SDA +SD +GQR ++ A+
Sbjct: 3656 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 3715
Query: 4456 TQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWA 4515
Q+ A + + + +RK+M I L D + Q++ K+ + +++ + L++
Sbjct: 3716 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFS 3775
Query: 4516 QGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKAC 4575
E+ E++K+ + K + L Y+++ S R LE+ V F E +++
Sbjct: 3776 HRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 3835
Query: 4576 HWLKQ--ADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
W+++ A I P + +E +L Q + + + E E++ + L + G L L
Sbjct: 3836 PWIEETRALIAQLPSPAIDHE--QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ-LKEL 3892
Query: 4634 NEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILAR---KEYASLIELTTQSLSEL 4690
N + + EK + I + + + EA+ E+ IE ++L L
Sbjct: 3893 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 3952
Query: 4691 EAQFLRMSKVPTDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ- 4748
++ +P ++ + E +S L+++ EA+ ++ G RS G
Sbjct: 3953 SSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG-RSQGADKDL 4011
Query: 4749 -----PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSK 4803
DK+ +V + +K + E+R D + EK + L ++K+ Q
Sbjct: 4012 AAKEIQDKLDQMVFFWEDIKARAEEREIKFLD---VLELAEKFWYDMAALLTTIKDTQDI 4068
Query: 4804 VNEETLPA------EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQ 4857
V++ P +++++ ++ L+ + I DL + R
Sbjct: 4069 VHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4128
Query: 4858 IQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRR--VKAELSGPVYLDL 4915
I + L E + + E M ++ +Q + DWL +K PV DL
Sbjct: 4129 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL 4188
Query: 4916 N-LQDIQEEIR--KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-LEHSLAELS 4971
N ++D E++ K++++Q++++ M L+H+ + KA + D + L EL
Sbjct: 4189 NTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDIIREPLTELK 4243
Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQ----LAGNGLDVES 5027
L ++ E + RQ L ++ + WL +ELL ++G D +
Sbjct: 4244 HLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG---DPKV 4300
Query: 5028 AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVA--SLELRSQRM 5085
E L H H ++ + AT++ + K G E LE + LRS R+
Sbjct: 4301 IEVELAKH----------HVLKNDVLAHQATVETVNK-AGNELLESSAGDDASSLRS-RL 4348
Query: 5086 SRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS---------H 5136
+ +LQ+ + Q ++ ++ E L E + +++ S
Sbjct: 4349 EAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPE 4408
Query: 5137 EAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDA-SKATLSRSMTTVWQRWTRL 5195
A E+L H L S + + E L +K + + +D+ S + +S+ + Q+W +
Sbjct: 4409 TAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVV 4468
Query: 5196 RAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHD 5255
+ ++++ LE+A++ T F N +++ + + L +S +L+ +E H
Sbjct: 4469 SSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHK 4528
Query: 5256 TF----------VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCL 5305
F ++EL+Q + L L Q+ +L + + ++Q R
Sbjct: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL-------------IKNLLVSVQSRWE 4575
Query: 5306 NMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLT 5365
+ ++ G+ + K + + W+++ + +L + +EI +++++ L+
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL-DSELEISNDPDKIKLQLS 4634
Query: 5366 EATNHRQNIE----------KMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIR-DQIQ 5414
+ ++ + + KEK T+LP + S +L +++ + D +
Sbjct: 4635 KHKEFQKTLGGKQPVYDTTIRTGRALKEK-----TLLPED-SQKLDNFLGEVRDKWDTVC 4688
Query: 5415 DKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK----------TDNVVQAKTDQKV 5464
K E + + S Q + L L K++ + D V+ KV
Sbjct: 4689 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQ 5524
+EL + L + ++ +E + + ++ +L+ + + ++ S+L Q
Sbjct: 4749 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQ 4808
Query: 5525 AASHLEEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLE--ESKEID- 5580
A E + + + ++L+W+ +A + L + L+ H+ ++ E K +D
Sbjct: 4809 ALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 4868
Query: 5581 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5640
+ AM E + + C + + + EE+ K Q L+ A ++
Sbjct: 4869 NSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAEL 4928
Query: 5641 LKKLQAALEQAQATLTSPEVGRL-----SLKEQLSHRQHLLSEMESLKPKVQAV 5689
L++L A ++ A+ TL + + +K ++ Q + EM +P V V
Sbjct: 4929 LEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982
Score = 325 bits (834), Expect = 9e-88
Identities = 863/4928 (17%), Positives = 1892/4928 (38%), Gaps = 646/4928 (13%)
Query: 2151 HLLSE--LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDE 2208
HL +E K HSS S + M T + + +S +E R L W + + + E
Sbjct: 547 HLKAEPLTKATHSSSTSWFRKPM--TRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLE 604
Query: 2209 IEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLK----EL 2264
W N+ L + EL E + + +EEL S V + + ++
Sbjct: 605 RAEWGND---------------LPSVELQLETQQHIHTS---VEELGSSVKEARLYEGKM 646
Query: 2265 TKNLETPPDLQFIEADLMQKLEHAK-EITEVAKGTLKDFTAQSTQVEKFINDITT---WF 2320
++N T A+ + KLE ++ E + ++ + + KF++ T W
Sbjct: 647 SQNFHTS------YAETLGKLETQYCKLKETSSFRMRHLQS----LHKFVSRATAELIWL 696
Query: 2321 TKVEESLM--NCAQNETCEALKK--VKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
+ EE + + + N + + K+ ++ EL+ +Q S Q+ L + H A+ +
Sbjct: 697 NEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK-Q 755
Query: 2377 SLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK-HFSESMQEFQEWFLGAKAAAKE--SS 2433
++ + + + + QLC + ++E+ F +E + + + + K S
Sbjct: 756 TVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSC 815
Query: 2434 DRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYA-------HLSKQIVSSIQ 2486
D LE L D + + + +S + ++ +T+ H+ K +S
Sbjct: 816 DHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTIS--- 872
Query: 2487 EQITKANEEFQAFLKQCLKDKQALQDCA--------SELGSFEDQHRKLNLWIHEMEERF 2538
+ + Q + C D+ L+D + S G+ L ++
Sbjct: 873 --VKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAI 930
Query: 2539 N-TENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRL 2597
+ +S Q + +++H L R+ LD L Q L G+ ++
Sbjct: 931 EMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLD-LVQTWNLEKLRSSAPGECHQI 989
Query: 2598 CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSK 2657
L +++ L+ +++ S ++ + LEE +++ KA L + +
Sbjct: 990 MKNLQAHYEDFLQDSRD---SVLFSVADRLRLEEEVEAC----KARFQHLMKSMENEDKE 1042
Query: 2658 DTLEKR-LSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWAD 2716
+T+ K +S++++I L E E ++ I Q+L SS + ++ W D
Sbjct: 1043 ETVAKMYISELKNIRLRLEEYEQRVVKRI----QSLASSRTD------------RDAWQD 1086
Query: 2717 IMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHL 2776
+ T E + QL +++V K + L P L L
Sbjct: 1087 NALRIAEQEHTQEDL-----------QQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSEL 1135
Query: 2777 QSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVE 2836
++L E DH L + KT D + EL + +I E
Sbjct: 1136 -NLLVEKMDHVYGLSTVYLNKL----KTVDVIVRSIQDAELLVKGYEIKL-------SQE 1183
Query: 2837 EIVKDHLMYLDAVHEFTDWLHSAKEELHRW-SDMSGDSSATQKKLSKIKELIDSREIGAS 2895
E+V L L+A W L W SD+ +S S + E I ++ A
Sbjct: 1184 EVVLADLSALEA-----HW-----STLRHWLSDVKDKNSV----FSVLDEEIAKAKVVAE 1229
Query: 2896 RLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSE 2955
++SR L PE D +++++ Q Q +++Q+ + +
Sbjct: 1230 QMSR---LTPE-------------------RNLDLERYQEKGSQLQERWHRVIAQLEIRQ 1267
Query: 2956 QEFSGQVAQLEQALEQFSALLK----TWAQQLTLLEGKNTDEEIVECWHKGQEILDALQK 3011
E L L+K T AQQ + G+ D ++ Q L A
Sbjct: 1268 SELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFA--- 1324
Query: 3012 AEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNC--LCLQASKGCQNKEQILQQRF 3069
E +++L++ +FS+ ST ++K+Y + +A Q K ++R
Sbjct: 1325 ---EIERNQTKLDQCQKFSQQYST-------IVKDYELQLMTYKAFVESQQKSPGKRRRM 1374
Query: 3070 RKAFRDFQQWLVNAKIT-TAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG 3128
+ Q ++ + TA Q++ +S +L++++E E + K +
Sbjct: 1375 LSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEE--EEKVVEEEKQEHVEKVK 1432
Query: 3129 ELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDW 3188
ELL + T A+ Q K T+++ E A+ ++ ++ E + +
Sbjct: 1433 ELLGWVSTL--ARNTQGKATSSETKEST------DIEKAILEQQVLSEELTTKKEQVSEA 1484
Query: 3189 LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASK 3248
+ ++ + + ++L E++K Q QLN L + L +G A
Sbjct: 1485 IKTSQIFLAKHGHKL-------SEKEKKQ--------ISEQLNALNKAYHDLCDGSA--- 1526
Query: 3249 SFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCH 3308
+++ QL SQ L++ T++K + + N +++L W+ A L +
Sbjct: 1527 ---NQLQQLQSQ---LAHQTEQKT-----LQKQQNTCHQQLEDLCSWVGQAERALAGHQG 1575
Query: 3309 PTS--DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNT----SPEGIPTIQQQ 3362
T+ D S L L+ L Q + +V E ++ SP + ++++
Sbjct: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK 1635
Query: 3363 LQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAEL 3422
L K+ + +L + +LE A++ Q L E++++ L
Sbjct: 1636 LHQAKEQYEALQEETRVAQKELEEAVTS-------ALQQETEKSKAAKELAENKKKIDAL 1688
Query: 3423 RDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKE 3482
D T +G + ++L+ +E ++ GA + + + D + Y + + ++
Sbjct: 1689 LDWVTSVGSS---GGQLLTNLPGME--QLSGASLEKGAL------DTTDGYMGVNQAPEK 1737
Query: 3483 AVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHC 3542
+ E + HQE + F + Q LDQ H H T + Q LQ
Sbjct: 1738 LDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ--------HGHNLTPEEQQMLQQKL 1789
Query: 3543 AEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRL 3602
E + ++ L E AE + +++L+ + Q +
Sbjct: 1790 GELKEQYSTSLAQSE---------AELKQVQTLQDELQKFL------------------- 1821
Query: 3603 MEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARA 3662
Q ++ + WL+ +E+++ + S+ T L + + E+V +++ ++ V
Sbjct: 1822 --QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISG 1879
Query: 3663 QEILD----------ESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESES 3712
Q++LD S + + + + T RY AL + L + + ++
Sbjct: 1880 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939
Query: 3713 SLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGE 3772
S S W + N + + + D ++ ++L T + L +++ + H + +K
Sbjct: 1940 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAE-HQVPVEKLQKVA 1998
Query: 3773 RAVKYLEEGEA---ERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
R + +E A +++ + + L+ ++ + L+K + ++ + ++L
Sbjct: 1999 RDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058
Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQD 3889
Q I E ++ L + + + L+ L+Q + + S+++ RE +E
Sbjct: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118
Query: 3890 VT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLV 3946
T L+ K+ ++ ++ LC +E SL+ + E + ++++++ S R++
Sbjct: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKS-RML 2177
Query: 3947 APDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNV 4006
A + QQ+ ME+ D L +L T + C L Q+
Sbjct: 2178 ASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLV----TELSSCGFALDLCQHQD- 2232
Query: 4007 HAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPP 4066
+Q + ++ + T + + ++ + ++ Q WL + + P+ +
Sbjct: 2233 --RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-ETS 2289
Query: 4067 LSRAEAIKQVKHFRALQE----QARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL 4122
+S E KQ++H ++L + + ++ C L N ++ TA D Q +I +
Sbjct: 2290 MSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSV 2349
Query: 4123 VQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKL 4182
+ G+ K L +E+ + D +N+ + V L
Sbjct: 2350 GSSVGSVNGYHTCKDL-TEIQCDMSD----------------VNLKYEKLGGV------L 2386
Query: 4183 QSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDY 4242
+Q S+ I+ ++ ++ HKE N + QWL+ +E++ ++ D
Sbjct: 2387 HERQESLQAILNRMEEV--------HKEANSVL-QWLE-----------SKEEVLKSMDA 2426
Query: 4243 HDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKM 4302
E ++ AES L L++ + +Q+ K A+ L +
Sbjct: 2427 MSSPTKTET------------VKAQAESNKAFLAELEQNSPKIQKVKEALAGL------L 2468
Query: 4303 IEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEE 4362
+ + N + E K+ L RW + ++ + + + L Q+ +L W E
Sbjct: 2469 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 2528
Query: 4363 QQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMA---DLGLNE 4419
++ + S P+M + E EA++ + L + A ++ D+ L+
Sbjct: 2529 KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLST 2588
Query: 4420 RQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFR 4479
QV ++ S Q V L+D + R +++A+ + TQ+ + + +++ +++ +
Sbjct: 2589 SQVQKELQSINQKWVE-LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 2647
Query: 4480 EHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQE-KSEVLGKLQE 4538
I P+ V +Q++ ++ L+ +EV EL + EQ K E+ +L+
Sbjct: 2648 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 2707
Query: 4539 LQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSEL 4598
+ + + R+ L+ L S + F++ FD+ WL + + L
Sbjct: 2708 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 2767
Query: 4599 HTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY-LSEKLNALPRQFNVIVA 4657
+QL + + + ++ + G+++L S+ + L +L L + +
Sbjct: 2768 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 2827
Query: 4658 LAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCR 4717
D+ ++++ + ++Y +E + + +A+ + + +E +L +
Sbjct: 2828 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS---K 2884
Query: 4718 AILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQ---RVSLLE 4774
A+L+EV ++ LN + ++ + + + + TE+ + LE
Sbjct: 2885 AMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLE 2944
Query: 4775 DTTSAYQEHEKMCQQLERQLKSVKEE---------QSKVNEETLPAEEKLKMYHSLAGSL 4825
+ T +E ++ + +E++++ K + Q+ N+ EKL+ + +L
Sbjct: 2945 EMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL----EKLRAQQEVLQAL 3000
Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
+ L+ T L + AP D + HQ + Q E + + E+++
Sbjct: 3001 EPQVDYLRNFTQGLVEDAP--DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3058
Query: 4886 SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALS 4945
F + L + EL G + + +Q +I +++ ++ + A
Sbjct: 3059 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3118
Query: 4946 HKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAA 5005
+ + + L L+ L L++ G + E + RQ L + + +Y+ +
Sbjct: 3119 AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGL 3178
Query: 5006 NDWLEDAQELLQLAGN-GLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLI 5063
ND A+E L G +VE + L F + D L++++ L LI
Sbjct: 3179 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLG---QGLI 3235
Query: 5064 KPTGKE----DLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMND 5119
+ GK+ LE + + R +++ ++ LQ +Q A E ++ + D
Sbjct: 3236 QSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD 3295
Query: 5120 TEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKA 5179
TE+ ++ ++ + ++ E K L +++ + L+ + ++ ++ A +
Sbjct: 3296 TEELIAN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE 3354
Query: 5180 TLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSA 5239
++ + ++ RWT L + A ++K LED + F+ + ++ + + KL S
Sbjct: 3355 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3414
Query: 5240 EKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ--QTLSMLQDGAAPTPGEEPPLMQEI 5297
A++ + H ++E + + + Q+LS L +P E+ L ++I
Sbjct: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLT-----SPAEQGVLSEKI 3469
Query: 5298 TAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE----- 5352
++Q R +Q++ L+ Q L + + V W+ E ++ L + ++
Sbjct: 3470 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 3529
Query: 5353 -IDAQLEELQILLTEATNHRQNIE---KMAEEQKEKYLGLYTILPSE----LSLQLAEVA 5404
+ Q + L E N ++N++ K + ++ G +L E + + A++
Sbjct: 3530 VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT 3589
Query: 5405 L-DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQK 5463
+ K ++ + + ++T +EL+ ++++ ++L T + + + Q + QK
Sbjct: 3590 VTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQ-SPTGEQIPQFQQRQK 3648
Query: 5464 VLGEE-------LDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAE 5516
L +E LD N E+ A+ + + + G L K + E ++
Sbjct: 3649 ELKKEVMEHRLVLDTVN----EVSRALLELVPWRAREG--LDKLVSDANEQYKLVSDTIG 3702
Query: 5517 NRLSKLNQAASHLEEYNEMLELILKWIE--KAKVLAHGTIAWNSASQLREQYILHQTLLE 5574
R+ +++ A ++Y + + L W+ K K++A G I +L + Q ++
Sbjct: 3703 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI------RLEQDQTTAQLQVQ 3756
Query: 5575 ESKEID--SELEAMTEKLQYLTSVY--CTEK----MSQQVAELGRETEELRQMIKIRLQN 5626
++ ID ++M E + + ++ C E+ + ++ L ++ E + + R
Sbjct: 3757 KAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYAR 3816
Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQAT---LTSPEVGRLSLKEQLSHRQHLLSEMESLK 5683
L+ A + +F ++L +E+ +A L SP + L++Q + L + K
Sbjct: 3817 LERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHK 3876
Query: 5684 PKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQ- 5742
P + + L+ + + + + ++++ Q+ + AV Q Q
Sbjct: 3877 PHIDKLLKIGPQLKELNPEEGEM-VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQI 3935
Query: 5743 --YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 5800
+ +++ + + +E + P+ + + +++ IS ++ +++ Q +L
Sbjct: 3936 TEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKR 3995
Query: 5801 KCKMLTMKAKHATMLLTVTEVEGLAEGT----EDLDGELLPTPSAHPSVVMMTAGRCHTL 5856
+ + L +++ A L E++ + ED+ V+ + + +
Sbjct: 3996 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM 4055
Query: 5857 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5916
+ +T + ++ SP ++ I Q +AE ++ + +H
Sbjct: 4056 AALLTTIKDTQDIVHDLESP--------------GIDPSIIKQQVEAAETIKEETDGLHE 4101
Query: 5917 STS-----ASQEFYEPGL--EPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQ 5969
+ + G +P + ++ +WE L E+ L +A++ +YQ
Sbjct: 4102 ELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQ 4161
Query: 5970 DSLQSISTKMEAIELKLSESPEPG---RSPESQMAEHQALMDEILMLQDEINELQSSLAE 6026
D+LQ++ ++ +KL P G + + Q+ E + E+ Q E+ +L E
Sbjct: 4162 DTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQ-GE 4220
Query: 6027 ELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQ 6086
++ ++ D ++ ++ LT L + K + ++ LE L AL
Sbjct: 4221 LMLKKA--TDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGAL----------LALG 4268
Query: 6087 RYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD---CQNMLVEIEQKVVALSEL 6143
+++ +EL SWL T+ LD +P +E +L +N ++ + V +++
Sbjct: 4269 QFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4328
Query: 6144 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE--ESD 6201
N LLE A D+A L +L + + + +++ +Q T Q+ + S+
Sbjct: 4329 G----NELLESSA--GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSE 4382
Query: 6202 VDLTATQSPGVQEWLAQARTT--WTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
++ + ++ L+ ++ T + + L EL +L ++ + +G +L
Sbjct: 4383 IEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML 4442
Query: 6260 IQHSAAETSGDAGEKPDVLSQE-----LGMEGEKSSAEDQMRM--KWESLHQEF------ 6306
+ + + + +L Q+ ME KS E+ + + ++++ QEF
Sbjct: 4443 LSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTL 4502
Query: 6307 --------STKQKLLQNVLEQEQEQVLYSRP-----NRLL----SGVPLYKGDVPTQDKS 6349
S +L VL Q +E +++ ++++ +G L K QD
Sbjct: 4503 AEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQL-KFLSQKQDVV 4561
Query: 6350 AVTSLLDGLNQAFEEV---SSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATA 6406
+ +LL + +E+V S + G + + ++ ++ WL+D E L
Sbjct: 4562 LIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 4621
Query: 6407 LL--PEETETCLFNQEILAKDIKEMSEEMD---------KNKNLFSQAFPENGDNRDVIE 6455
+ P++ + L + K + D K K L PE+ D
Sbjct: 4622 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL----LPEDSQKLD--- 4674
Query: 6456 DTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVF 6515
LG + V + + + +L++ L F +L D Y + +LA
Sbjct: 4675 ----NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAE-- 4728
Query: 6516 EQPVAEQIEAIQQAEDGLKEFD------AGIIELKRRGDKLQVEQPS------MQELSKL 6563
+QPV ++ + D K F G +++ +R + +E +L +L
Sbjct: 4729 DQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQEL 4788
Query: 6564 QDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEI 6623
+D + + S++S L Q L + + L + L ++ + + + E +
Sbjct: 4789 STRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEAL 4847
Query: 6624 QQLLDKHKEYFQGLESHMI-----------------------------LTETLFRKIISF 6654
Q L+D HKE+ + +E + + F +++++
Sbjct: 4848 QSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTW 4907
Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSH---LDEDQQELSRQLEVVESS 6711
A Q + + T L S ++ A L +I W+ + DQ+ + + ++ V++
Sbjct: 4908 AKQHQQRLETAL----SELVANAELLEELLAWI--QWAETTLIQRDQEPIPQNIDRVKAL 4961
Query: 6712 IPSVGLVEENEDRL---IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLIS--------I 6760
I E R +DR+T K+ + P + + G++ L +
Sbjct: 4962 IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPIL 5021
Query: 6761 SCSDLES-QLNQLGECW-------LSNTNKMSKELHRLETILKHWTRYQSE--SADLIHW 6810
S S+ ++ ++NQL W L K++ L RLE LK + + + + W
Sbjct: 5022 SQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE-LKEFANFDFDVWRKKYMRW 5080
Query: 6811 LQSAKDRL 6818
+ K R+
Sbjct: 5081 MNHKKSRV 5088
Score = 317 bits (813), Expect = 3e-85
Identities = 820/4346 (18%), Positives = 1669/4346 (38%), Gaps = 589/4346 (13%)
Query: 4507 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR-- 4564
+ EV A+ + LMK + ++K E + K+ Y S L+ RL+E E+ +V R
Sbjct: 1019 EEEVEACKARFQHLMKSMENEDKEETVAKM------YISELKNIRLRLEEYEQRVVKRIQ 1072
Query: 4565 --KHFKEDFDKACHWLKQADIVTFPEI---NLMNESSELHTQLAKYQNILEQSPEYENLL 4619
+ D D W A + E +L S+L K + L QSP ++
Sbjct: 1073 SLASSRTDRDA---WQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSV- 1128
Query: 4620 LTLQRTGQTILPSLN----EVDHSY--LSEKLNALPRQFNVIVALAKDKFYKVQEAILAR 4673
T+ LN ++DH Y + LN L + +VIV +Q+A L
Sbjct: 1129 -------PTLRSELNLLVEKMDHVYGLSTVYLNKL-KTVDVIVR-------SIQDAELLV 1173
Query: 4674 KEYA---SLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAV 4730
K Y S E+ LS LEA + + +D+ + ++ ++LDE + V
Sbjct: 1174 KGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVF------SVLDEEIAKAKVV 1227
Query: 4731 DELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4790
E + R+ +K L +HR+ Q E R S LE ++ L
Sbjct: 1228 AEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTL 1287
Query: 4791 ERQLKSVKEEQSKVN----EETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAP-- 4844
+ ++ +Q + E++ E+L +L ++ + L + + +
Sbjct: 1288 IKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIV 1347
Query: 4845 ---HLDPLAYEKARHQIQSWQGELKLLTS---AIGETVTECESRMVQSIDFQTEMSRSL- 4897
L + Y+ Q G+ + + S AI + + +R + T+ + +
Sbjct: 1348 KDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYIS 1407
Query: 4898 DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKE 4957
D LRR++ E + + EE + Q H E+V+ L ++ L+ + K T ++
Sbjct: 1408 DALRRLEEE-----------EKVVEEEK--QEHVEKVKELLGWVSTLARNTQGKATSSET 1454
Query: 4958 LISADLEHSLAELSELDGD-------IQEALRTRQATLT---------EIYSQCQRYYQV 5001
S D+E ++ E L + + EA++T Q L E ++ +
Sbjct: 1455 KESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNAL 1514
Query: 5002 FQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDP 5061
+A +D + + LQ + L ++ ++ L+ ++ H LE+L S V +
Sbjct: 1515 NKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQ------QNTCHQQLEDLCSWVGQAER 1568
Query: 5062 LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTE 5121
+ +Q +++L+ ++Q +D Q D+ R T+ + +++ M + +
Sbjct: 1569 ALAGHQGRTTQQDLSALQ-KNQSDLKD--LQDDIQNRATS----FATVVKDIEGFMEENQ 1621
Query: 5122 KKLSEFSLL----KTSSSHEAEEKLSEH---------KALVSVVNSFHEKIVALEEKASQ 5168
KLS L K + E E L E +A+ S + EK A +E A
Sbjct: 1622 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 1681
Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
+K DA ++ ++ Q T L + Q LE + T V +A E +D
Sbjct: 1682 KKKI--DALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 1739
Query: 5229 QLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPG 5288
+ + + KA LL F+L + Q+ L Q G TP
Sbjct: 1740 KQCEMM---------KARHQELLSQQQNFILATQSAQAFLD----------QHGHNLTPE 1780
Query: 5289 EEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN 5348
E+ L Q++ G+L +Q E ++ V+ E +++L +
Sbjct: 1781 EQQMLQQKL-----------------GELKEQYSTSLAQSEAELKQVQTLQDELQKFLQD 1823
Query: 5349 PTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LAEVAL- 5405
+E + L + +N+ K + LPS L Q +E +
Sbjct: 1824 H--------KEFESWLERSEKELENMHKGGSSPET--------LPSLLKRQGSFSEDVIS 1867
Query: 5406 ---DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ 5462
DL+ K+ ++E S +E S +I L KD KLK T+ +
Sbjct: 1868 HKGDLRFVTISGQKVLDMENSFKEGKEPS-EIGNLVKD------KLKDATERYTALHSKC 1920
Query: 5463 KVLGEEL--------------DGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELH 5508
LG L D + + +A V+K L + ++ T+
Sbjct: 1921 TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL 1980
Query: 5509 QQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA--KVLAHGTIAWNSAS-QLREQ 5565
Q+ + + + + KL + A + E + +++ +L+H + S S L E+
Sbjct: 1981 QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH----FQSLSYSLAER 2036
Query: 5566 YILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQ 5625
L Q + +S+ + LE++ + + + +QV+ L +++ + ++
Sbjct: 2037 SSLLQKAIAQSQSVQESLESLLQSIGEVEQ----NLEGKQVSSLSSGV--IQEALATNMK 2090
Query: 5626 NLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS-----LKEQLSHRQHLLSEME 5680
QD A+ EA + + +E A +T + G+L+ ++ +Q S ++
Sbjct: 2091 LKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLK 2150
Query: 5681 SLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 5740
L P+ + + L+ + E SR+ +
Sbjct: 2151 KLLPQAEMFEHLSGKLQ----------------QFMENKSRM--------------LASG 2180
Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS---------RHEELAQKI--- 5788
Q +Q++ H Q I+ + E+ED+ ++ L ++S +H++ Q +
Sbjct: 2181 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2240
Query: 5789 -----KGYQEQIASLNSKCKMLTMKAKHA-TMLLTVTEVEGLAEGTE-DLDGELLPTPSA 5841
K +E+ +S + L K T + E EG TE + + L
Sbjct: 2241 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2300
Query: 5842 HPSVVMMTAGRCHTLLSPVT-EESGEEGTNSEISSPPAC-RSPSPVANTDASVNQDIAYY 5899
H ++ TL+ + + + E EI++P + ++ S + + +SV Y+
Sbjct: 2301 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2360
Query: 5900 QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLY 5959
+Q D + D+ +E L V+ E+Q +L
Sbjct: 2361 TCKDLTEIQCD--------------------------MSDVNLKYEKLGGVLHERQESLQ 2394
Query: 5960 EALERQQKYQDSLQSISTKMEAIELKLSE-----SPEPGRSPESQMAEHQALMDEILMLQ 6014
L R ++ S+ +E+ E L SP + ++Q ++A + E+
Sbjct: 2395 AILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNS 2454
Query: 6015 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6074
+I +++ +LA LV+ + +Q L ER + + +
Sbjct: 2455 PKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR----------- 2503
Query: 6075 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6134
QLEE A ++ +L WL+ + + +P + AQ Q ML E E
Sbjct: 2504 QLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFE 2561
Query: 6135 QKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDK-----QLN 6189
+ +L+ + +L G Q+ +L+ + +EL L+ + Q
Sbjct: 2562 ARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAI 2620
Query: 6190 MQGTAQEKEESDVD---LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQ---ELAE 6243
++ T ++ D+ Q VQ ++ QQ + + + + +LEQ E+ E
Sbjct: 2621 VKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKE 2680
Query: 6244 QKSLLRSVASR-GEEIL-------IQHSAAETSGD---AGEKPDVLSQELGMEGEKSSAE 6292
++L ++ GE+ L ++ A G A ++ + L L +
Sbjct: 2681 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 2740
Query: 6293 DQMRMKWESLHQE------FSTKQKLLQNVLEQEQE------------QVLYSRPNRLLS 6334
D++R + + S K + LQ+ L++ +E +V+ + LL
Sbjct: 2741 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLL 2800
Query: 6335 GVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-----IHLEQKLYDGVSA 6389
VP P ++K + + L L +EE+S ++ A RQS + QK V
Sbjct: 2801 SVP------PGEEKRTLQNQLVELKNHWEELSKKT--ADRQSRLKDCMQKAQKYQWHVED 2852
Query: 6390 TSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 6448
W++D + ++ + L P + E+ L + + ++++ ++ + +
Sbjct: 2853 LVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE 2912
Query: 6449 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII- 6507
+ D I D + + + + + ++E Q++ FQ K + + K+ +
Sbjct: 2913 ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLE 2972
Query: 6508 ------LQKLANVFEQPVAEQIEAIQQAE---DGLKEFDAGIIELKRRGDK----LQVEQ 6554
Q +N + + Q E +Q E D L+ F G++E G L +
Sbjct: 2973 IFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAE 3032
Query: 6555 PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 6614
+ QE +++ + +++ ++ G+ Q + L DL D L+ G + D
Sbjct: 3033 VAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD-GMGAIGRDTD 3091
Query: 6615 IIVSSKEEIQQLLDKHKEYFQGLES------HMILTETLFRKIISFAVQKETQFHTELMA 6668
+ S E+++ L+K +E+ HM+ E + +++E + L
Sbjct: 3092 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL---GLKRELE---ALNK 3145
Query: 6669 QASAVLKRAHKRGVELEYIL---ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRL 6725
Q + +R R +LE L E + + + + E E+ VG E ++
Sbjct: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
Query: 6726 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTN 6781
+ ++Q K ++ Q KL QV G+ L+ S LE + ++ W +
Sbjct: 3206 LADFKMFQ--KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK 3263
Query: 6782 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 6841
K+++ + +L+ L H ++Q L+ WL ++ + S E ++V+ +
Sbjct: 3264 KVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQE 3319
Query: 6842 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-DTATLRSELSRIDSQWTDLLTNIPAVQE 6900
+ +D + + + + G ++ + ++ D + +L ++S+WT+LL+ A Q+
Sbjct: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
Query: 6901 KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKI 6958
+L + + + ++S+ E + E +G + I + + ++K +
Sbjct: 3380 QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP-----VGTQTAKIQQQIIRHKALEE 3434
Query: 6959 DINCKQLTVDF---VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015
DI V + QS+ ++S + S+K D ++ + +Q K
Sbjct: 3435 DIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID------SLQARYSEIQDRCCRKAA 3488
Query: 7016 LLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAK 7074
LL+ L + + E+ V+ L E ++K + Q + D L + I +
Sbjct: 3489 LLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNR 3548
Query: 7075 EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSS 7134
+K V++ +NG AL++ + ++ L + +A++ + L+ +
Sbjct: 3549 KKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 3608
Query: 7135 HKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKF 7190
+ ++++ +L E L+ +G Q+ Q Q +L+K+ L
Sbjct: 3609 FQSTYEELTGWLREVEEELAT----SGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 3664
Query: 7191 GSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQ 7250
++ LL+ E L + + N ++ + + I +++ A +Q Q+Y+ Q
Sbjct: 3665 NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----Q 3720
Query: 7251 CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQL 7310
A T L A + D+ +Q + KDS+ L ++
Sbjct: 3721 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
Query: 7311 KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVE 7370
+ +Q SL Q A+ ++ L+ + F ++ E L WI E
Sbjct: 3781 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 3840
Query: 7371 AEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LNDKE--- 7426
++ Q PS + D ++++ EE++ + P +D+L ++G +L LN +E
Sbjct: 3841 TRALI-AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899
Query: 7427 -IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT---FLEKCETWMEFLVQTEQKLAVE 7482
++ Q ++ I + +R L + Q F +K E +E L +L +
Sbjct: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
Query: 7483 --ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLK 7536
I + E ++ E+ Q ++ G+ L+ + Q D+D E K
Sbjct: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019
Query: 7537 LTLLSNQWQGVIRRAQQRR----GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
L + W+ + RA++R +++ + W + ++ V L G+
Sbjct: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079
Query: 7593 VPIPLQ--QARTLFDEVQ--FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELA 7648
I Q A T+ +E +E F+R G+ L+ + + ++ +
Sbjct: 4080 SIIKQQVEAAETIKEETDGLHEELEFIRILGA---------DLIFACGETEKPEVRKSID 4130
Query: 7649 EIQEKWKSASMRLEEQKKKLAFLLK---DWEKCEKGIADSLEK--------------LRT 7691
E+ W++ + +E+ +KL ++ ++ + + D L+ L T
Sbjct: 4131 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNT 4190
Query: 7692 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 7751
K +L++ + + E++ +Q+ ++L + +L L K T D I+
Sbjct: 4191 VKDQLNE-MKEFKVEVYQQQIEMEKLNHQ--------GELMLKKAT-----DETDRDIIR 4236
Query: 7752 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ----NG 7807
E + L+ WE L +++ R+ ++ L F +EL WLT E + +G
Sbjct: 4237 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG 4296
Query: 7808 DILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
D + E +E K + +A + ++ + + G L ++S AS + +L +N W
Sbjct: 4297 DPKVIE-VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4355
Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQR 7924
+ +L R ++L+ TL Q + L +ES+L+ KP E +
Sbjct: 4356 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT---GGLPETARE 4412
Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
+L+ EL ++ +L+ ++L D + ++ + Q+ L+++W +
Sbjct: 4413 QLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVS 4469
Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
+ ER+ K+EE L +F + F +WL +E++ S +I ++++ +
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV 4529
Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
F +V+ Q+ +++ +L ++ +K ++ RW+ + +R R L
Sbjct: 4530 FANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD 4589
Query: 8105 HFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNK 8162
+ ++F A ++ WL + + L + +E ++ D ++ ++ + K FQ+ +
Sbjct: 4590 DARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPV 4649
Query: 8163 IEQIIAQGEQLIEKS-EPLDAAIIEEELDELRRYCQEVFGR-VERYHKKLIRLPLPDDEH 8220
+ I G L EK+ P D+ ++ L E+R V G+ VER HK L
Sbjct: 4650 YDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFM 4709
Query: 8221 DLSDRELE---------LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSG 8271
D ++ ED DL D+ Q Q L+ RSG
Sbjct: 4710 DALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK--RSG 4767
Query: 8272 RD-----------TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE---------EGQ 8311
R+ + + WD LS +S + +AL + E
Sbjct: 4768 RELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWL 4827
Query: 8312 DDKDFYLRGAVGLSGDHSALESQI---RQLGKALDDSRFQIQQT----ENIIRSKTPTGP 8364
+ + LR L D AL+S I ++ K +++ R + E I+ P
Sbjct: 4828 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL---AVCHP 4884
Query: 8365 ELDTSYKGYMKLLGECSSSIDSVKRLEHKL---KEEEESLPGFVNLHSTETQTAGVIDRW 8421
+ T+ K ++ ++ R E L K+ ++ L ET + ++
Sbjct: 4885 DCITTIKHWITIIR---------ARFEEVLTWAKQHQQRL---------ETALSELVANA 4926
Query: 8422 ELLQAQALSKELRMKQNLQKWQQ-FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8480
ELL+ + +Q+ Q+ +++ + A + + + +E++ R + D T
Sbjct: 4927 ELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTY 4986
Query: 8481 QIKKLKEL------QKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRV 8534
+ K ++ + RK++ P +Q+++K R++Q++ RW +V
Sbjct: 4987 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAK-----NPRINQLSARWQQV 5041
Query: 8535 CSLLEEWRGLLQDALMQCQGFHEMSH 8560
L E + L DAL + + E ++
Sbjct: 5042 WLLALERQRKLNDALDRLEELKEFAN 5067
Score = 295 bits (754), Expect = 2e-78
Identities = 808/4676 (17%), Positives = 1776/4676 (37%), Gaps = 536/4676 (11%)
Query: 1121 EDPDKWKDYTSRFSEFSSWIS------------TNETQLKGIKGEAIDTANHGEVKRAVE 1168
E +W++Y SR WI N +LK + + I + E + +
Sbjct: 311 EVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYI---HFKETEILAK 367
Query: 1169 EIRNGVTKRGETL--SWLKSRLKVLTEVSSENEAQKQGDEL--------AKLSSSFKALV 1218
E G + L W++ L + N+ +++ +L L + + L
Sbjct: 368 EREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLE 427
Query: 1219 TLLSEVEKMLSNFGDCVQYKEIVKNSLE---ELISGSKEVQEQAEKIL---DTENLFEAQ 1272
LL K+ + +C + + KN+L+ + + VQ +++ I+ + E L
Sbjct: 428 LLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQL 487
Query: 1273 QLLL-----HHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKL--ESTLDGLE 1325
Q+ L + + + ++ + +Q ++ + L +GH +L STL
Sbjct: 488 QVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTH 547
Query: 1326 RSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFL--SFSSLESLSSELEQTK 1383
E + + W R + +V + RF+ S +E + +LE+
Sbjct: 548 LKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERA- 606
Query: 1384 EFSKRTESIAVQAENLVK-EASEIPLGPQNKQLLQQQAK-------SIKEQVKKLEDTLE 1435
E+ S+ +Q E S LG K+ + K S E + KLE
Sbjct: 607 EWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLE---T 663
Query: 1436 EDIKTMEMVKTKWDHFGSNFETLS------VWITEKEKELNALETS--SSAMDMQISQIK 1487
+ K E + H S + +S +W+ EKE+E A + S +S + + +
Sbjct: 664 QYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFS 723
Query: 1488 VTIQEIESKLSSIVGLEEEAQSF------AQFVTTGESARIKAKLTQIRRYGEELREHAQ 1541
E+E K L++ A+ A+ SA ++++L +++ + +H +
Sbjct: 724 ELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVK 783
Query: 1542 CLEGT-ILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQ 1600
E T S ++ E LR +Q S+ K +S + +LQ+ MD +
Sbjct: 784 --ENTAYFQFFSDARELESFLRNLQDSI-----KRKYSCDHNTSLSRLEDLLQDSMDEKE 836
Query: 1601 ALESLSSAITAFSASARKVV-------------------------------NRDSCVQEA 1629
L S++ + ++ +V D CV E
Sbjct: 837 QLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLED 896
Query: 1630 AALQQQY-----------------------EDILRRAKERQTALENLLAHWQRLEKELSS 1666
+ + ++ +D + A + + + ++A W +L S
Sbjct: 897 NSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKS 956
Query: 1667 FLTW--------------LERGEAKASSPEMDIS----------------------ADRV 1690
++W LE+ + A I ADR+
Sbjct: 957 LISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRL 1016
Query: 1691 KVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP 1750
++E E++ +A ++ S + KE + ++K ++L LE+ ++R
Sbjct: 1017 RLEEEVEACKARFQHLMK-----SMENEDKEETVAKMYISELKNIRLRLEEYEQR----- 1066
Query: 1751 QIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKD-H 1809
+ KRI L S + + + L + Q S++ + + H+
Sbjct: 1067 --VVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPS 1124
Query: 1810 AAEVESKKGELQSL---QGHLAKLGS--LGRAEDLHLLQGKAEDCFQLFEEASQVVERRQ 1864
++ V + + EL L H+ L + L + + + ++ +D L + + + +
Sbjct: 1125 SSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEE 1184
Query: 1865 LALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAV 1924
+ L+ L+ L++H S LR V+ NS+ + I K A Q ++ +
Sbjct: 1185 VVLADLSA-LEAHWS---TLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNL 1240
Query: 1925 SLD-----GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVL 1979
L+ G + ++H I E R S + ++ G+ L E A +
Sbjct: 1241 DLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEM 1300
Query: 1980 KKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLK 2039
K Q + +L E + ++T E + L Q + Q + +E +L K
Sbjct: 1301 MKPGQAEDSRVLS--EQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK 1358
Query: 2040 ----------DKAKQIAQKDVAFAPE-----------VDREINRLEVTWDDTKRLIHENQ 2078
K +++ A E V ++ D +RL E +
Sbjct: 1359 AFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEK 1418
Query: 2079 GQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYK 2138
+ + + + L VS + N T + K+ D++ A + + ++ K
Sbjct: 1419 VVEEEKQEHVEKVKELLGWVSTLARNTQGK-ATSSETKESTDIEKAILEQQVLSEELTTK 1477
Query: 2139 QKDLDN-------FTSKGKHLLSEL-KKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMD 2190
++ + F +K H LSE KK S + + D + ++L+ +
Sbjct: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537
Query: 2191 RLRVSLSIWDDVLSTRDEIE---GWSNNCVPQMA--------ENISNLDNHLRAEELLKE 2239
++ + ++E W +A +++S L + + LK+
Sbjct: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN---QSDLKD 1594
Query: 2240 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ---KLEHAKEITEVAK 2296
+ +++N+A + + E + +P +L + L Q + E +E T VA+
Sbjct: 1595 LQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQ 1654
Query: 2297 GTLKDFTAQSTQVE--------------KFINDITTWFTKVEES----LMN--------- 2329
L++ + Q E K I+ + W T V S L N
Sbjct: 1655 KELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSG 1714
Query: 2330 --------------CAQNETCEALKKVKDIQK----ELQSQQSN-ISSTQENLNSLCRKY 2370
N+ E L K ++ K EL SQQ N I +TQ L +
Sbjct: 1715 ASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 1774
Query: 2371 H--SAELESLGRAMTGLIKKHEAVSQLCSKTQ----ASLQESLEKHFSESMQEFQEWFLG 2424
H + E + + + G +K+ + S S+ + +LQ+ L+K F + +EF+ W
Sbjct: 1775 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK-FLQDHKEFESWLER 1833
Query: 2425 AKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY--------AH 2476
++ + + L + L + + V + L VT GQ +
Sbjct: 1834 SEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK 1893
Query: 2477 LSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEME- 2535
+I + +++++ A E + A +C + L + F++ L W+ E
Sbjct: 1894 EPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEA 1953
Query: 2536 --ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQ 2593
E+ ++ + + E+ +++ L E E L K+++ ++ EG A
Sbjct: 1954 NVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR--DIMEIEGEPAPD 2011
Query: 2594 EGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACA 2650
+ +L+ Q+L E+ Q A+ + ++++E+L+S+ + ++ L
Sbjct: 2012 HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK 2071
Query: 2651 E-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQ 2706
+ S+L S ++ L + QDI K E M + + +++ V+Q +
Sbjct: 2072 QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV----TRFMETADSTTAAVLQGK 2127
Query: 2707 LETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGL 2766
L + + + + +S+L+ ++ Q + +L+Q+ME+ + + QP +
Sbjct: 2128 LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDI 2187
Query: 2767 KEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMT 2826
F + L + + +++ L L+ + + +D Q L+ F ++
Sbjct: 2188 THFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQ-NLRKDFTELQK 2246
Query: 2827 VAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKEL 2886
KE+ + + + V F WL + + ++ S + +K++ +K L
Sbjct: 2247 TVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP-TETSMSAKELEKQIEHLKSL 2305
Query: 2887 IDS--------REIGASRLSR----VESLAPEVKQNT------------------TASGC 2916
+D EI S +E AP+ + T T
Sbjct: 2306 LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL 2365
Query: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976
+ +M + +++ + + Q L+ ++++M +E + + Q LE +L
Sbjct: 2366 TEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRM----EEVHKEANSVLQWLESKEEVL 2421
Query: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
K+ + + E + + L L++ P+ + +K L L L TY
Sbjct: 2422 KS----MDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL------LVTY 2471
Query: 3037 SGKVSG-----LIKEYNCLCLQASKGCQNKEQILQQR------FRKAFRDFQQWLVNAKI 3085
+ +E N +A++ +++ L++ F+ A + WL+ ++
Sbjct: 2472 PNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKEL 2531
Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESE--NGQHKLNMMLSKGELLSTLLTKEKAKGI 3143
+ + + ++ Q++Q L E E QH+ ++G L +
Sbjct: 2532 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQV 2591
Query: 3144 QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKT----EKMVHES 3199
Q ++ + + W L+ + S ++ ++ ++ E +QD K +++ +S
Sbjct: 2592 QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQ---ELLQDLSEKVRAVGQRLSVQS 2648
Query: 3200 SNRLYDLPAKRR--EQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQL 3257
+ K++ E +++S LE++ + L ++ L Q + R+ +
Sbjct: 2649 AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV 2708
Query: 3258 SSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLD 3317
+ L +L ++++RL +A QF EL+ W+ D C ++ L
Sbjct: 2709 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 2768
Query: 3318 SRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP-EGIPTIQQQLQSVKDMWASLLSA 3376
S+ + E + ++IV GES+L + P E T+Q QL +K+ W L
Sbjct: 2769 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 2828
Query: 3377 GIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLN 3436
+S+L+ + K YQ V W++ +A ++E ++ ++++L +LN
Sbjct: 2829 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 2888
Query: 3437 EEVLSYSSLLETIE------VKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKL 3490
EV SLLE + + + E + E + + A+ E + E++
Sbjct: 2889 -EVEKRRSLLEILNSAADILINSSEADEDGIRD-EKAGINQNMDAVTEELQAKTGSLEEM 2946
Query: 3491 VRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLN 3550
+ +E+Q K E + + +L+ + L A ++ ++L++L+ QAL
Sbjct: 2947 TQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSN----KNLEKLRAQQEVLQALEP 3002
Query: 3551 SVLHTRE--DVIPSGIPQAEDRA-----LESLRQDWQAYQHRLSETRTQFNNVVNKLRLM 3603
V + R + P D + E +Q++ + R++ N + +
Sbjct: 3003 QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3062
Query: 3604 EQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQ 3663
+ +++ L ++++ + + + Q+ ++ + ++ + ++E A +
Sbjct: 3063 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3122
Query: 3664 EILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3723
+L+E +G L +AL Q K E E+ E +L D+Y
Sbjct: 3123 HMLEEEGTLDLLG-----LKRELEALNKQC---GKLTERGKARQEQLELTLGRVEDFYRK 3174
Query: 3724 THKNFKNVATKIDKVDTV--MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEG 3781
K + T ++ + + ++G +++ + L D + + + V L +G
Sbjct: 3175 L-KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3233
Query: 3782 EAERLRKE-----IHDHMEQLKELTSTVRKE----HMTLEKGLHLAKEFSDKCKALTQWI 3832
+ K+ + ME++ +T+ K+ L++ L +F D + L W+
Sbjct: 3234 LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWL 3293
Query: 3833 AEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL---LELVQD 3889
A+ +E++ + P E KAQ+ + K LQ+ + + +V ++ +G + EL
Sbjct: 3294 ADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADR 3353
Query: 3890 VTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPD 3949
+ +++ L+S + +L S LE + + ++ + + +L +L +
Sbjct: 3354 EKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSE 3413
Query: 3950 LLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAH 4009
+ T + + I QQ+ HKA+ E+I ++ G +L + Q L + + +
Sbjct: 3414 PVGTQTAK-IQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSL 3472
Query: 4010 LQGTKDSYSAICSTAQRMYQSLEHEL---QKHVSRQDTLQQCQAWLSAV------QPDLE 4060
+ C A + Q+L + + V + L + + LS+V Q L
Sbjct: 3473 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLH 3532
Query: 4061 PSPQPPLSRAEAI--------KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQ 4112
L+ E I + +K+ +AL +Q T ++L L +KT DI
Sbjct: 3533 RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQT-TGEEVLLIQEKLD--GIKTRYADIT 3589
Query: 4113 QTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMV 4172
T + L QA+ L + + EL +L++ +++L + E +
Sbjct: 3590 VTSSKALRTLEQARQLA---TKFQSTYEELTGWLREVEEELATSGGQSPTGE------QI 3640
Query: 4173 SQVKDFVKKLQSKQASVNTIIEKVNKLTK--------KEESPEHKEINHLNDQWLDLCRQ 4224
Q + K+L+ + +++ VN++++ + K ++ N+Q+ +
Sbjct: 3641 PQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDT 3700
Query: 4225 SNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLA--RSDAESTAVHLEALKKLA 4282
+ + +QR++ Y + ++ + + L R + + T L+ K +
Sbjct: 3701 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 3760
Query: 4283 LALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTN 4342
+ + K ++++L + ++ + K +++E+T L Q++ + L +
Sbjct: 3761 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSER----YAR 3816
Query: 4343 LEELNVVQSRF----QELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398
LE V+ ++F +EL W EE + IA Q P P +DH + + E +
Sbjct: 3817 LERAQVLVNQFWETYEELSPWIEETRALIA----QLPSP------AIDHEQLRQQQEEMR 3866
Query: 4399 MLLKSLIKDADRV---------MADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
L +S+ + + + +L E +++++ A++ + + V QR L+
Sbjct: 3867 QLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALD 3926
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC----KSAQASLKT 4505
+A+S+ TQ + ++ E L+P +V K ++ C KSA L+
Sbjct: 3927 EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK-IRECISDNKSATVELEK 3985
Query: 4506 YQNEVTGLWAQGRELMKEVTEQEK----SEVLGKLQELQSVYDSVLQKCSHRLQELEKNL 4561
Q L +G EL+ +K E+ KL ++ ++ + + R + L
Sbjct: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
Query: 4562 VSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLT 4621
+ F D +K + + + S + Q+ + I E++ L
Sbjct: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
Query: 4622 LQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE 4681
++ G ++ + E + + + ++ + + + K++ K+++A+ A +Y ++
Sbjct: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQ 4165
Query: 4682 LTTQSLSELEAQFLRMSKVPTDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQK---- 4736
L + M V TDL V++ L+ + EV +++LN +
Sbjct: 4166 AMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKV---EVYQQQIEMEKLNHQGELM 4222
Query: 4737 -KEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLK 4795
K+ T + + + L L+ L + R LE A + + ++L L
Sbjct: 4223 LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLT 4282
Query: 4796 SVKE---EQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE 4852
+E Q ++ + E +L +H L + ++ V +L
Sbjct: 4283 HTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDAS 4342
Query: 4853 KARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVY 4912
R ++++ + + E + +S + Q+ F +E+ L L R++++LS
Sbjct: 4343 SLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKP 4402
Query: 4913 LDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELIS-ADLEHSLAELS 4971
+ +E++ ++++ N L K + + S + E S+A L
Sbjct: 4403 TGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLE 4462
Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG-NGLDVESAEE 5030
+ + + R++ L E + + Q +WL A++ L +A L + +
Sbjct: 4463 QKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLS 4522
Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRM---SR 5087
++ H F + + + EL L L + ++ + S++ R +++ S
Sbjct: 4523 QIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI 4582
Query: 5088 DSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKA 5147
+ G +D ++ Q+H+ A +++I+ + D E L + L ++ + + +LS+HK
Sbjct: 4583 ERGRSLDDARKRAKQFHE---AWKKLIDWLEDAESHL-DSELEISNDPDKIKLQLSKHKE 4638
Query: 5148 LVSVVNSFHEKI-VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKIL 5206
+ + + EKT L + V +W + + +++ L
Sbjct: 4639 FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKL 4698
Query: 5207 EDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQS 5266
E+A+ F + ++ + + +++ +L ++ L++ H F EL ++
Sbjct: 4699 EEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTG 4758
Query: 5267 ALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDRE 5326
+ +L++ ++++ T + L QE++ D + ++ ++Q LK E
Sbjct: 4759 TVQVLKRSGRELIENSRDDTTWVKGQL-QELSTRWDTVCKLSVSKQSR---LEQALKQAE 4814
Query: 5327 MVETQINSVKCWVQETKEYLGNPTIEIDAQL-EELQILLTEATNHRQNIEKMAEEQ 5381
+ ++ + W+ E ++ T+ L ++ + L + H++ ++K+ E++
Sbjct: 4815 VFRDTVHMLLEWLSEAEQ-----TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR 4865
Score = 293 bits (749), Expect = 7e-78
Identities = 761/4237 (17%), Positives = 1608/4237 (37%), Gaps = 493/4237 (11%)
Query: 576 SVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKM 635
++E A V + + A W L V +S+ S W+ + +Q W + EK+
Sbjct: 929 AIEMASRVEQSYQKVMALWHQLHVNTKSLIS--------WNYLRKDLDLVQTW--NLEKL 978
Query: 636 LNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFM 695
+ + +NL + + + L D + L++++ R++ L
Sbjct: 979 RSSAPGECHQIMKNLQAHYEDFL-QDSRDSVLFSVADRL---RLEEEVEACKARFQHLMK 1034
Query: 696 EVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQR 755
M+ KE T + +S K + LE V IQ L
Sbjct: 1035 S---------MENEDKEETVAKMYISEL-----KNIRLRLEEYEQRVVKRIQSLASSRTD 1080
Query: 756 VPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS-PLLYESQQLL 814
I + H T+E Q+ ++ A K L + S P L LL
Sbjct: 1081 RDAWQDNALRIAEQEH--TQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLL 1138
Query: 815 IPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEK 874
+ + +++ Y L K+ + + V+ R Q + L + ++ L+ +E L+ +E
Sbjct: 1139 VEKMDHVYGLSTVY--LNKL-KTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEA 1195
Query: 875 GSQSVQKFVTLSNVL-KHFDQTRLQRQIADIHVAFQSMVKKTG----DWKKHVETNSRLM 929
+++ + LS+V K+ + L +IA V + M + T D +++ E S+L
Sbjct: 1196 HWSTLRHW--LSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ 1253
Query: 930 KKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDIL 989
+++ A+LE I Q LE +E+L D R + L E T
Sbjct: 1254 ERWHRVIAQLE----IRQSELESI---QEVLG---------DYRACHGTLIKWIEETTAQ 1297
Query: 990 PEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLM 1049
E + G E R L +Q ++ A +E +T+LD+ K
Sbjct: 1298 QEMMKPGQAEDSRVLSEQLS-----------------QQTALFAEIERNQTKLDQCQKFS 1340
Query: 1050 PQEGSEKIIKEHRV------FFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHV 1103
Q + I+K++ + F + ++R L + D T T V
Sbjct: 1341 QQYST--IVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMD--LRTRYTALV 1396
Query: 1104 TLKELRAAIDSTYRKLMEDPDKW-----KDYTSRFSEFSSWISTNETQLKGIKGEAIDTA 1158
TL S + +E+ +K +++ + E W+ST +G K + +T
Sbjct: 1397 TLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQG-KATSSETK 1455
Query: 1159 NHGEVKRAVEEIR----NGVTKRGETLSWLKSRLKVLTEVS---SENEAQKQGDELAKLS 1211
++++A+ E + TK+ + +K+ L + SE E ++ ++L L+
Sbjct: 1456 ESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALN 1515
Query: 1212 SSFKALVT-LLSEVEKMLSNFGDCVQYKEIVK--NSLEELISGSKEVQEQAEKILDTENL 1268
++ L ++++++ S + K + K N+ + + QAE+ L
Sbjct: 1516 KAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQG 1575
Query: 1269 FEAQQLLLHHQQKTKRISAKKRDVQQQ---IAQAQQGEGGLPDRGHEEL--RKLESTLDG 1323
QQ L Q+ + + D+Q + A + G + +L R+L + +
Sbjct: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK 1635
Query: 1324 LERSRERQE----------RRIQVTLRKWERFETNKETVVRYLFQT-------------- 1359
L +++E+ E + ++ + + ET K + L +
Sbjct: 1636 LHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSV 1695
Query: 1360 GSSHERFLS-FSSLESLSS----------------------ELEQTKEFSK-RTESIAVQ 1395
GSS + L+ +E LS +L++ E K R + + Q
Sbjct: 1696 GSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQ 1755
Query: 1396 AENLVKEASEIP---------LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1446
+N + L P+ +Q+LQQ+ +KEQ E ++K ++ ++
Sbjct: 1756 QQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQD 1815
Query: 1447 KWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK--------VTIQEIESKLS 1498
+ F + + W+ EKEL + S+ + S +K V + + +
Sbjct: 1816 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFV 1875
Query: 1499 SIVGLE--EEAQSFAQFVTTGESAR-IKAKLTQIRRYGEELREHAQCLE-----GTILGH 1550
+I G + + SF + E +K KL L H++C +LG
Sbjct: 1876 TISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL--HSKCTRLGSHLNMLLGQ 1933
Query: 1551 LSQQQKFEENLRKIQQSVSE-----FEDKLAVPIKICSSATETYKVLQEHMDLCQA-LES 1604
Q Q ++L+ Q+ D +A + T K LQE + Q +E
Sbjct: 1934 YHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEK 1993
Query: 1605 LSSAITAFSASARKVVNRDSCVQEAA-ALQQQYEDILRRAKERQTALENLLAHWQRLEKE 1663
L + VQE ++ ++ + ER + L+ +A Q +++
Sbjct: 1994 LQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2053
Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
L S L + E ++ + V ++ L L+ ++ Q S ++
Sbjct: 2054 LESLLQSIGEVEQNLEGKQVSSLSSGV-IQEALATNMKLKQDIARQKSSLEATREMVTRF 2112
Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1781
A +++ L ++ +R+ L ++ + L+ ++ + + F+ L ++
Sbjct: 2113 METADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMEN 2172
Query: 1782 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDL 1839
++ S Q +I+ Q+ ++ E+E ++ L +L+ + +L S G A DL
Sbjct: 2173 KSRMLASGNQPDQDITHFFQQI-----QELNLEMEDQQENLDTLEHLVTELSSCGFALDL 2227
Query: 1840 HLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
Q + ++ + F E + V+ R+ S E L L ++ + E S+
Sbjct: 2228 CQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLK--ETEGSIPP 2285
Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKI---GSSEQRTSCRATADQLC 1956
E+ + K+L +++ K+L LD SK +I G+S + TA
Sbjct: 2286 TETSMSAKELEKQIEHLKSL------LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQ 2339
Query: 1957 GEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQ 2015
G+ I +G+ + K E+ + D+ + +K + +++LQ
Sbjct: 2340 GKTGSILPSVGSSVGSVNGYHTCK-----DLTEIQCDMSDVNLKYEKLGGVLHERQESLQ 2394
Query: 2016 QRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIH 2075
L ++ E NS L WL+ K + + D +P + ++ + K +
Sbjct: 2395 AILNRMEEVHKEANS---VLQWLESKEEVLKSMDAMSSP---TKTETVKAQAESNKAFLA 2448
Query: 2076 ENQGQCC-------GLIDLMREYQNLKSAVS--KVLENASS--VIVTRTTIKDQEDLK-- 2122
E + L L+ Y N + A + K+ E +S T T+ Q L+
Sbjct: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEES 2508
Query: 2123 ----------------WAFSKH----------------ETAKNKMNYKQKDLDNFTSKGK 2150
W K K ++ + K+ + + +
Sbjct: 2509 ASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE 2568
Query: 2151 HLLSELKKIHS--SDFSL----VKTDMESTVDKWLDVSEKL---EENMDRLRVSLSIWDD 2201
L + I + D SL V+ +++S KW+++++KL +D+ V + + +
Sbjct: 2569 QLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 2628
Query: 2202 VLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDL 2261
+L E V Q S + A + E SE+++ LE+L +V +
Sbjct: 2629 LLQDLSE----KVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEA 2681
Query: 2262 KELTKNLETPPDLQFIEADLMQKLEHA-------KEITEVAKGTLKDFTAQSTQVEKFIN 2314
+ L L Q+++ +L ++LE +++ L+ A + Q ++ +
Sbjct: 2682 QTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFD 2741
Query: 2315 DITTWF-TKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL-----NSLCR 2368
++ TW K + NC + E L+ +E Q + S + E + + L
Sbjct: 2742 ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS 2801
Query: 2369 KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAK 2426
E +L + L E +S+ + Q+ L++ ++K + +++ W K
Sbjct: 2802 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 2861
Query: 2427 AAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQ 2486
A E T D LE+ L + +L+ V +S L+ + L + S+ I+
Sbjct: 2862 AKMSELR-VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL-INSSEADEDGIR 2919
Query: 2487 EQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT-ENLGE 2545
++ N+ A ++ +L++ L F++ + + + + + + LG
Sbjct: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG- 2978
Query: 2546 SKQHIPEKKNEVHKVEMFLGELLAARE-SLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS 2604
Q K E + + E+L A E +D L Q L E+ +L Q +
Sbjct: 2979 -SQACSNKNLEKLRAQQ---EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3034
Query: 2605 HQNLLRMTKEKLRSCQVALQEHEALEE---ALQSMWFWVKAIQDRLACAESTLGSKDTLE 2661
Q L + + C + + E + + ++ M+ + + D L + D+L+
Sbjct: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRV----IQTQLETLKEVWADI 2717
SQI+D+ L + V L + I E R +E + ++ +LE L + +
Sbjct: 3095 ---SQIEDVRLFLNKIHV-LKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL 3150
Query: 2718 MSSSVHAQSTLESVISQWNDYVERKNQLE------------QWMESVDQKIEHPLQPQPG 2765
Q LE + + D+ + L QW+ + +I +
Sbjct: 3151 TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFK 3210
Query: 2766 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIM 2825
+ +K +D LQ L + + L + K ++ D EE+ ++N +
Sbjct: 3211 MFQK-EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD-------MEEINARWNTLN 3262
Query: 2826 TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSK--- 2882
+++ +++E + + DA+ WL +E + S + + ++ +
Sbjct: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322
Query: 2883 IKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQS 2942
++ L+D R+ + + +++ + Q+ + E + ++++L + W + Q
Sbjct: 3323 LQRLLDDRK---ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
Query: 2943 CLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG 3002
LE++ + L++ Q + E S L ++L E T K
Sbjct: 3380 QLEDI---LVLAK--------QFHETAEPISDFLSVTEKKLANSEPVGTQTA------KI 3422
Query: 3003 QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS-----GKVSGLIKEYNCLCLQASKG 3057
Q+ + + E E+ + +++ + + LS+ + G +S I +
Sbjct: 3423 QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3482
Query: 3058 CQNKEQILQQRFRKAFR------DFQQWL--VNAKITTAKCFDIPQNI--SEVSTSLQKI 3107
C K +L Q A + WL V K+++ D Q++ + + L
Sbjct: 3483 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALN 3542
Query: 3108 QEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESA 3167
+E ++ +N ++ + G+ L T E+ IQ K+ K + + +
Sbjct: 3543 EEIVNRKKN----VDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 3598
Query: 3168 LENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYE 3227
LE + F+ + E + WL + E+ + S + + QQ+ + + +E+ +
Sbjct: 3599 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 3658
Query: 3228 PQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQF 3285
L+ + E ++ L E A + VS + QY +S+ ++V +D + Q+
Sbjct: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718
Query: 3286 SLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK--QEKEIQMKMIVTR 3343
W+ + L + P + + L+++ S+ + K+ ++ R
Sbjct: 3719 EQAADAELAWVAETKRKLMA-LGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777
Query: 3344 GESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3403
E + E +Q++ +S+ + ++ ++LE A + + + S
Sbjct: 3778 SE-IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836
Query: 3404 WMD---SMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETI-----EVKGAG 3455
W++ ++ A L H +LR + + + L E + + ++ + ++K
Sbjct: 3837 WIEETRALIAQLPSPAIDHEQLRQQQE---EMRQLRESIAEHKPHIDKLLKIGPQLKELN 3893
Query: 3456 MTEHYVTQLELQDLQERYRAIQERAK-------EAVTKSEKLVRLHQEYQRDLKAFEVWL 3508
E + + + Q + Y I+E + EAV++S ++ H + + L+ E
Sbjct: 3894 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE--- 3950
Query: 3509 GQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
+L ++ + + D + V + Q ++ E++I +
Sbjct: 3951 -NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009
Query: 3569 DRALESLRQD-------WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK- 3620
D A + ++ W+ + R E +F +V L L E+ + + L T ++
Sbjct: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDV---LELAEKFWYDMAALLTTIKDTQ 4066
Query: 3621 ----------VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESH 3670
+ P +Q A + I+ EE +E+E + +++
Sbjct: 4067 DIVHDLESPGIDPSIIKQQVEAAETIK--------EETDGLHEELEFIRILGADLIFACG 4118
Query: 3671 VNSRMGCQAT--QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGST---H 3725
+ + + ++ + ++ L E+++ LE+ +Q+ + + +L + DW +T
Sbjct: 4119 ETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKL 4178
Query: 3726 KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAV-KYLEEGEAE 3784
V T ++ V + K +EV + +E ++ +GE + K +E + +
Sbjct: 4179 CTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRD 4233
Query: 3785 RLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
+R+ + + + L + LE L +F + L W+ +E+L
Sbjct: 4234 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4293
Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV---QDVTLKDKIDQLQS 3901
+ + +L+K+ L+ VL+H+ +V++V + G LLE +L+ +++ +
Sbjct: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4353
Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSL-ETIT 3960
++ + +E L++ ++ + ++SE+++ L +M +L A T L ET
Sbjct: 4354 CWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASK--PTGGLPETAR 4411
Query: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 4020
+QL H + ++ E+ N L KG ++ D + A L+ + +
Sbjct: 4412 EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLE---QKWHVV 4468
Query: 4021 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4080
S + LE L Q++LQ+ WL+ + L + P L + Q++ +
Sbjct: 4469 SSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHK 4528
Query: 4081 ALQEQARTYLDLLCSMCDLSN-----------ASVKTTAKDIQ-QTEQTIEQKLVQAQNL 4128
+ + D + + N +K +Q + E+ +++ + + ++L
Sbjct: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
Query: 4129 TQGWEEIKHLK---SELWIYLQDADQQLQNMKRRHSELELNIAQNMV----SQVKDFVKK 4181
+ K +L +L+DA+ L SELE++ + + S+ K+F K
Sbjct: 4589 DDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLSKHKEFQKT 4642
Query: 4182 LQSKQASVNTIIEKVNKLTKKEESPEHKE-----INHLNDQWLDLCRQSNNLCLQREEDL 4236
L KQ +T I L +K PE + + + D+W +C +S + EE L
Sbjct: 4643 LGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEAL 4702
Query: 4237 QRTRDYHDCMNVVEVFLEKFTTEW--DNLARSDAESTAVHLEALKKLALALQERKYAIED 4294
+ + D + + +L K + D D + ++A K L +R ++
Sbjct: 4703 LFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQV 4762
Query: 4295 LKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQ 4354
LK +++IE+ + DD VK Q L RW + L K L++ V +
Sbjct: 4763 LKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVH 4821
Query: 4355 ELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMAD 4414
L+EW E + + + Q+L+ H ++E K++ + S + + ++A
Sbjct: 4822 MLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAV 4881
Query: 4415 LGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHER 4474
+ I+ ++ ++ + Q ++ L ALSE + + + IQ E
Sbjct: 4882 CHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAET 4941
Query: 4475 KIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4511
++ R+ + + + + K+ A +T+ E+T
Sbjct: 4942 TLIQRDQ-----EPIPQNIDRVKALIAEHQTFMEEMT 4973
Score = 277 bits (708), Expect = 4e-73
Identities = 782/4130 (18%), Positives = 1624/4130 (39%), Gaps = 503/4130 (12%)
Query: 4751 KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLP 4810
+M HL +L+ + R T + + L E +E E++ ++ +++ +E T+
Sbjct: 675 RMRHLQSLHKFVSRATAELIWLNE------KEEEELAYDWSDNNSNISAKRNYFSELTME 728
Query: 4811 AEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTS 4870
EEK ++ SL QD T L L H E +QS +K L
Sbjct: 729 LEEKQDVFRSL----QD--------TAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCL 776
Query: 4871 AIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLN--LQDIQEEIRKIQ 4928
+ + V E + F ++ +LR ++ + D N L +++ ++
Sbjct: 777 CVEQHVKENTAYF----QFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSM 832
Query: 4929 IHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD-GDIQEALRTRQAT 4987
+E++ S + +L + K L+++++ + D I+ +
Sbjct: 833 DEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDEC 892
Query: 4988 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 5047
+ E SQ ++ + N+ + + L N +E A +S+ + + Q H
Sbjct: 893 VLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHV 952
Query: 5048 NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY- 5106
N + L S L DL Q +LRS G +++ A + D+
Sbjct: 953 NTKSLISWNYLRKDL-------DLVQTWNLEKLRSSA----PGECHQIMKNLQAHYEDFL 1001
Query: 5107 QKAREEVIELMNDTEKKLSEFSLLKTSSSH---EAEEKLSEHKALVSVVNSFHEKIVALE 5163
Q +R+ V+ + D + E K H E + E ++ + LE
Sbjct: 1002 QDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLE 1061
Query: 5164 EKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKA 5223
E ++ K + SR+ WQ LR Q+ + ++ + +
Sbjct: 1062 EYEQRVVKRIQSLAS---SRTDRDAWQD-NALRIAEQEHTQ------EDLQQLRSDLDAV 1111
Query: 5224 TEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSML---- 5279
+ D + P SS+ ++EL L+E D V L S + + + +T+ ++
Sbjct: 1112 SMKCDSFLHQSPSSSSVPTLRSELNLLVEKMD-HVYGL----STVYLNKLKTVDVIVRSI 1166
Query: 5280 QDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWV 5339
QD G E L QE + D L+ E + + ++KD+ V + ++
Sbjct: 1167 QDAELLVKGYEIKLSQEEVVLAD--LSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKA 1224
Query: 5340 QETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE------EQKEKYLGLYTILP 5393
+ E + T E + LE Q ++ + E E ++ LG Y
Sbjct: 1225 KVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACH 1284
Query: 5394 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI----------------QKL 5437
L + E ++ K + E S+ S++LS+Q QK
Sbjct: 1285 GTLIKWIEETTAQQEMM-----KPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKF 1339
Query: 5438 AKDLTTILT--KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5495
++ +TI+ +L+ T ++ QK G+ L DA Q+F++
Sbjct: 1340 SQQYSTIVKDYELQLMTYKAF-VESQQKSPGKR----RRMLSSSDAITQEFMD------- 1387
Query: 5496 PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE----YNEMLELILKWIEKAKVLAH 5551
L + L L Q ++ + L +L + +EE + E ++ +L W+ LA
Sbjct: 1388 -LRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVS---TLAR 1443
Query: 5552 GTIAWNSASQLREQYILHQTLLEE---SKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
T ++S+ +E + + +LE+ S+E+ ++ E ++E ++ TS K +++E
Sbjct: 1444 NTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIK--TSQIFLAKHGHKLSE 1501
Query: 5609 LGRE--TEELRQMIKIRLQNLQDAAKDMKKFEAEL--KKLQAALEQAQATLTSPEVGRLS 5664
++ +E+L + K +A +++ +++L + Q L++ Q T S
Sbjct: 1502 KEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCS 1561
Query: 5665 LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQH 5724
Q + R + + + + A+Q QS L+ +D + + A + E ++
Sbjct: 1562 WVGQ-AERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 1620
Query: 5725 TAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEEL 5784
+ A + Q +++ + LQ+ A +E+E+ TS +Q+ + +EL
Sbjct: 1621 QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEE--AVTSALQQETEKSKAAKEL 1678
Query: 5785 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPS 5844
A+ K +++ +T LLT G E L G L + +
Sbjct: 1679 AENKK-------KIDALLDWVTSVGSSGGQLLTNLP------GMEQLSGASLEKGALDTT 1725
Query: 5845 VVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSA 5904
G G N ++P + D A +Q L +
Sbjct: 1726 -------------------DGYMGVN---------QAPEKL---DKQCEMMKARHQELLS 1754
Query: 5905 ERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWETLKNVISEKQRT 5957
++ A T ++Q F + P + KLG+L+ + T + +
Sbjct: 1755 QQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ 1809
Query: 5958 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILMLQ 6014
+ + QK+ + + +E E +L + G SPE S + + ++++ +
Sbjct: 1810 VQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869
Query: 6015 DEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRMKASGKRQLLEE 6070
++ + S + L E+ + E + + L ER + + K + L
Sbjct: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTR----LGS 1925
Query: 6071 KLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQN 6128
LN L + Q ++ AD L +W+ + +A ++ LS +P ++ QL +
Sbjct: 1926 HLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQ 1979
Query: 6129 MLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRRLKGSLLELQRA 6182
+ E+ + V + +L V + + +EG+ H ++ + + + L SL E + +
Sbjct: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE-RSS 2038
Query: 6183 LHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---QSSLQQQKELEQ 6239
L K + + QE ES QS G E + + + Q +L +L+Q
Sbjct: 2039 LLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQ 2093
Query: 6240 ELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
++A QKS L R + +R E +AA G E Q + EK S+ ++
Sbjct: 2094 DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2153
Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLD 6356
+ E + + S K LQ +E + L G+ P QD + +
Sbjct: 2154 PQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPDQDITHFFQQIQ 2195
Query: 6357 GLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCL 6416
LN E+ +++++ + L +S+ LD + + V L + TE
Sbjct: 2196 ELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN-LRKDFTELQK 2246
Query: 6417 FNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRC 6476
+E KD E++D+ + L + +++T G S+ + +
Sbjct: 2247 TVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------SIPPTETSMSA 2292
Query: 6477 HQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEF 6536
+++++++ + + +D T + + + E + E Q + G
Sbjct: 2293 KELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAPDSQGKTGSILP 2347
Query: 6537 DAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERAL 6595
G G + +Q ++S + Y++L ++ R+ L L + +
Sbjct: 2348 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2407
Query: 6596 QDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH----MILTETLFRK 6650
+ LE+ +E + + +K E ++ + +K + LE + + E L
Sbjct: 2408 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2467
Query: 6651 IISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---DEDQQELSRQLE 6706
++++ +E + ++ + ++ +RA + V + LE + SHL + +L L
Sbjct: 2468 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 2527
Query: 6707 VVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLL-----ISIS 6761
E + +G + + + L + Q + + + Q+ + + +L +S+S
Sbjct: 2528 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 2587
Query: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
S ++ +L + + W+ T+K++ +++ + T+YQ DL +++ RL
Sbjct: 2588 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 2647
Query: 6822 TQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQLLR---LKKVDT 6874
+ Q V Q+LE + + + EV +AQ+ + G Q L+ K+++T
Sbjct: 2648 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 2707
Query: 6875 ATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDE 6934
L L ++ D + + A Q Q E+ +W+ ++ K
Sbjct: 2708 VAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWLDDKQSQQAK-- 2756
Query: 6935 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQDVESKRSDKTD 6991
N S + + LQ+ + F+ +N + + + +S+L +S E KR+
Sbjct: 2757 -NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVPPGEEKRT---- 2810
Query: 6992 FAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRI 7051
QL + W+ L ++ L+ ++ +Y+ +V+ L W E + ++ +
Sbjct: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 2870
Query: 7052 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI----------VM 7101
D ++++L + + + ++ + +E + LI + + D I +
Sbjct: 2871 LDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMD 2930
Query: 7102 STLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINSYLMEARYSLSR 7155
+ EL +L+ M +L+ +S + + + H++ FD + S + +L +
Sbjct: 2931 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNK-NLEK 2989
Query: 7156 FRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKE 7215
R L+A++ QVD L+N L + GS +QLL + E L E
Sbjct: 2990 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVAQQEFL-----E 3040
Query: 7216 VNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQCASTVQQQEDR 7261
V R N+ ++E E + Q + +++ + D + S Q ED
Sbjct: 3041 VKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDV 3100
Query: 7262 TNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
L K K DI E +C +L+ GT+ D L EL KQ +
Sbjct: 3101 RLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEALNKQCGKLTERG 3154
Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE-EILQGQD 7379
+ +QL L+ L +E K + G+ D T A+ EAL+ W+V E EI+ Q
Sbjct: 3155 KARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVVGTEVEIINQQ- 3205
Query: 7380 PSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWS 7438
+D Q E+++ L+ ++ + + + L + G + E M+ +N W+
Sbjct: 3206 ---LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE-HDMEEINARWN 3259
Query: 7439 LISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRA 7496
++ + +R ++LQ LL F + E + +L TE+ +A + S Y+ + Q +
Sbjct: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3319
Query: 7497 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7556
+L Q + R+ + + +G R+ + ++ DR++ +L L ++W ++ +A R+
Sbjct: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
Query: 7557 IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVF 7614
++ + +++ E AE + +L S S P+ Q A+ ++ K E+
Sbjct: 3380 QLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436
Query: 7615 LRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWKSASMRLEEQKK 7666
V+ G Q L S S AE +LQA +EIQ++ + L++
Sbjct: 3437 ENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
Query: 7667 KLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAEQM-RCKELENA 7720
+D + +A+ +KL + FK+ + H L+ E + R K ++ A
Sbjct: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 3555
Query: 7721 VGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN 7780
+ + +LLK T + +++ ++ E+++ ++ ++ ++ S + + +
Sbjct: 3556 IKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ 3604
Query: 7781 EWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAIAQENKIQLQQM 7839
F +EL WL ++E +++ +G E I + ++ +E E+++ L +
Sbjct: 3605 LATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 3664
Query: 7840 GERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMS 7895
E +++A E +A E ++ + N++++ + D I RV ++ + QQ ++
Sbjct: 3665 NE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723
Query: 7896 SLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVL 7953
+ W+A + +L PI + ++ +L Q+ DI +H + + + +
Sbjct: 3724 AELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
Query: 7954 LHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFED 8013
C + + +Q+ T +L +++ I ++ ER ++E L +F + Y
Sbjct: 3781 FGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836
Query: 8014 WLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 8073
W++ + A S + + +++ ++ + + E ++ + K +L N +
Sbjct: 3837 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 3896
Query: 8074 SACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARDSILVWLTEMD- 8128
+MV E Q+ +N+ ++ +R+ L + Q + D I L ++
Sbjct: 3897 G-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLEN 3951
Query: 8129 ---------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8179
L ++ EC I K+ E+ E + +GE+LI +S+
Sbjct: 3952 LSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006
Query: 8180 LD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL 8235
D A I+++LD++ + +++ R E +RE++ D L
Sbjct: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------EREIKFLDVLEL 4047
Query: 8236 SDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDL 8295
++ W+D +A L + + + ++ L P + + ++I E D L +L
Sbjct: 4048 AEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETD---GLHEEL 4103
Query: 8296 ESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENI 8355
E G+ +K + ++ L ++ + L+D+ Q ++
Sbjct: 4104 EFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDT 4163
Query: 8356 IRS----------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 8405
+++ K T P + T L E V+ + +++ E+ + G +
Sbjct: 4164 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQIEMEKLNHQGEL 4221
Query: 8406 NLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 8456
L +T I R WE L + ++ +++ L QF L + +WL
Sbjct: 4222 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4281
Query: 8457 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-K 8515
TEE L+ + +S D + IE+++ K L+ V +A + ++N E ++ +
Sbjct: 4282 THTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGD 4339
Query: 8516 ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNE 8575
++ L+ RL MN W+ V EE LQ L Q QGFH LL L ++ + +
Sbjct: 4340 DASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSA 4399
Query: 8576 IVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVASLQDMSCQLLVNAEGTD 8627
P E L H + Q+K ++LL+ + +D S +
Sbjct: 4400 SKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA 4459
Query: 8628 CLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 8677
LE +K HV+ ++++ + S+ + L + +S Q+ +W + E
Sbjct: 4460 LLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFINWLTLAE 4504
Score = 276 bits (706), Expect = 6e-73
Identities = 853/4660 (18%), Positives = 1774/4660 (38%), Gaps = 700/4660 (15%)
Query: 3706 SLEESESSLSSYSDWYGSTHKNFK-NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3764
S+EE SS+ + G +NF + A + K++T K +T ++ ++ H +
Sbjct: 628 SVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLK-ETSSFRMRHLQSLHKFV 686
Query: 3765 KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDK 3824
A + + +L E E E L + D+ + + + M LE+ + + D
Sbjct: 687 SRATAE----LIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT 742
Query: 3825 CKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALL 3884
AE + + P + +E Y Q S+ + ++Q L E VK + A
Sbjct: 743 --------AELLSLENHPAKQTVEAYSAAVQ-SQLQWMKQLCLCVEQHVK----ENTAYF 789
Query: 3885 ELVQDVT-LKDKIDQLQSDYQDLCSIGKEHVFS-LEAKVKDHEDYNSELQEVEKWLLQMS 3942
+ D L+ + LQ + S S LE ++D D +L + + + +
Sbjct: 790 QFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLV 849
Query: 3943 GRLVAPDLLETSSLETITQQLAHHKAMME-----------EIAGFEDRLNNLQMKGDTLI 3991
GR L+ S + + + KA+ + + ED + K +
Sbjct: 850 GRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPT 909
Query: 3992 GQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQ---SLEHELQKHVSRQDTLQQC 4048
G +A + KD+ + S ++ YQ +L H+L HV+ + +
Sbjct: 910 GN-----EAMVPSVCFLIPPPNKDAIE-MASRVEQSYQKVMALWHQL--HVNTKSLI--- 958
Query: 4049 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4108
+W + ++ DL+ L + + + + ++ Y D L D SV +
Sbjct: 959 -SW-NYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRD----SVLFSV 1012
Query: 4109 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIA 4168
D + E+ +E + Q+L + E ++ +Y+ + L+N++ R E E
Sbjct: 1013 ADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISE----LKNIRLRLEEYE---- 1064
Query: 4169 QNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE----INHLNDQWLDLCRQ 4224
Q +V +++ + A + + + +E+ + + ++ D +L
Sbjct: 1065 QRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPS 1124
Query: 4225 SNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARS--DAE-----------ST 4271
S+++ R E + V+L K T D + RS DAE
Sbjct: 1125 SSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTV-DVIVRSIQDAELLVKGYEIKLSQE 1183
Query: 4272 AVHLEALKKLALALQERKYAIEDLKD--------------------QKQKMIEHLNLDDK 4311
V L L L ++ + D+KD Q ++ NLD
Sbjct: 1184 EVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLD-L 1242
Query: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQE----LMEWAEE----- 4362
E +E+ S L++RW + + ++++ + LE + V ++ L++W EE
Sbjct: 1243 ERYQEKGSQLQERWHR----VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQ 1298
Query: 4363 --------------------QQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLK 4402
Q AE + D Q + I + E + M K
Sbjct: 1299 EMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK 1358
Query: 4403 SLIKDADRVMADLG--LNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLM 4460
+ ++ + L+ I + D ++ L L Q KY++ AL +
Sbjct: 1359 AFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEK 1418
Query: 4461 AVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4511
V + + Q+H K+ + R +K+ + A + E+T
Sbjct: 1419 VVEE---EKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELT 1475
Query: 4512 GLWAQGRELMK-----------EVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4560
Q E +K +++E+EK ++ +L L Y + +++LQ+L+
Sbjct: 1476 TKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ 1535
Query: 4561 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4620
L + K L + + H QL +++ + E L
Sbjct: 1536 LAHQTEQK---------------------TLQKQQNTCHQQL---EDLCSWVGQAERALA 1571
Query: 4621 TLQ-RTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKD--KFYKVQEAILARKEYA 4677
Q RT Q L +L + + S L + + + + + KD F + + L+ +E
Sbjct: 1572 GHQGRTTQQDLSALQK-NQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELT 1630
Query: 4678 SLIELTTQSLSELEA--QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQ 4735
+L E Q+ + EA + R+++ + AV AL + E+A + +D L
Sbjct: 1631 ALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLD 1690
Query: 4736 KKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLK 4795
S+G ++L + +L + ++ +L DTT Y + ++L++Q +
Sbjct: 1691 WVTSVGSSG-----GQLLTNLPGMEQLSGASLEKGAL--DTTDGYMGVNQAPEKLDKQCE 1743
Query: 4796 SVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKAR 4855
+K ++E L ++ + A + D H +L P + +
Sbjct: 1744 MMKAR----HQELLSQQQNFILATQSAQAFLDQ---------HGHNLTP--------EEQ 1782
Query: 4856 HQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD-------WLRRVKAELS 4908
+Q GELK S ++ + E+ + Q Q E+ + L WL R + EL
Sbjct: 1783 QMLQQKLGELKEQYST---SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELE 1839
Query: 4909 GPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLA 4968
+ + + +++ E+V +SHK +F D+E+S
Sbjct: 1840 NMHKGGSSPETLPSLLKRQGSFSEDV---------ISHKGDLRFVTISGQKVLDMENSFK 1890
Query: 4969 E---LSELDGDIQEALRTRQATLTEIYSQCQRY----------YQVFQAANDWLEDAQEL 5015
E SE+ +++ L+ T ++S+C R Y FQ + D L+ +
Sbjct: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
Query: 5016 LQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKED----- 5070
+ L ++ + E +T Q L E V L + + + +
Sbjct: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
Query: 5071 ----LEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSE 5126
+++ S+ Q +S + LLQ+ AQ Q++ E +++ + + E+ L E
Sbjct: 2011 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNL-E 2069
Query: 5127 FSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMT 5186
+ + SS +E L+ + L + + A E ++ +T + + A L +
Sbjct: 2070 GKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLA 2129
Query: 5187 TVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAE 5246
V QR+ +L Q++E L+ + + F + K + ++ L + +
Sbjct: 2130 EVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQ---D 2186
Query: 5247 LLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLN 5306
+ + LE+E QQ L L + G A ++ QDR N
Sbjct: 2187 ITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFA----------LDLCQHQDRVQN 2236
Query: 5307 MQEKVKTNGKLVKQELKDREMVETQINSVKC-------WVQETKEYLGNPTI------EI 5353
+++ K VK+ KD + Q++ + W++ET+ + PT E+
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIP-PTETSMSAKEL 2295
Query: 5354 DAQLEELQILLTE--------------ATNHRQNIEKMAEEQKEKYLGLYTILPSELSL- 5398
+ Q+E L+ LL + T+ I ++ + G +ILPS S
Sbjct: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG--SILPSVGSSV 2353
Query: 5399 ----------QLAEVALDLKIRDQIQDKIKEVEQSKATS-QELSRQIQKLAKDLTTILTK 5447
L E+ D+ + +K+ V + S Q + +++++ K+ ++L
Sbjct: 2354 GSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQW 2413
Query: 5448 LKAK---------------TDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ--N 5490
L++K T+ V K EL+ + K+ ++ A+ L N
Sbjct: 2414 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPN 2473
Query: 5491 GQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK--- 5547
Q + K +L ++ R +L ++ASHL + + W+ + +
Sbjct: 2474 SQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMM 2533
Query: 5548 -VLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTS-----VYCTEK 5601
VL +I N + ++Q Q +L+E + + E + E Q + + T +
Sbjct: 2534 GVLGPLSIDPNMLNAQKQQV---QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ 2590
Query: 5602 MSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAA-------LEQAQAT 5654
+ +++ + ++ EL + R + A +++ L+ L L A
Sbjct: 2591 VQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAI 2650
Query: 5655 LTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ-LCQS-ALRIPEDVVASLPLCHAA 5712
T PE ++K+QL + S++E L +V+ Q LC ++ I E +
Sbjct: 2651 STQPE----AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD----ELK 2702
Query: 5713 LRLQEEASRLQ---HTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS 5769
RL+ A LQ A + N +QAA+ +Q++Q L+ ++ + ++
Sbjct: 2703 KRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA 2762
Query: 5770 NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE 5829
++ LQ+Q+ +EE +Q+ + + +++ A+ ++LL+V E
Sbjct: 2763 KLERLQSQLQENEE-------FQKSLNQHSGSYEVIV--AEGESLLLSVPP----GEEKR 2809
Query: 5830 DLDGELLPTPSAHPSVVMMTAGRCHTL----------------LSPVTEESGEEGTNSEI 5873
L +L+ + + TA R L L P E+ + + +
Sbjct: 2810 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 2869
Query: 5874 SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSA 5933
+ P + S + + A +N+ + S + AA I ++S E E G+
Sbjct: 2870 TLDPV-QLESSLLRSKAMLNE---VEKRRSLLEILNSAADILINSS---EADEDGIRDEK 2922
Query: 5934 TAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI--ELKLSESPE 5991
+ ++ + + + K +L E +R +++Q+S ++I K+E +L++ ++
Sbjct: 2923 AG----INQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 2978
Query: 5992 PGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLA 6051
+ + +A + + L+ +++ L+ + + LV ++ + A QL Q+ V
Sbjct: 2979 SQACSNKNLEKLRAQQEVLQALEPQVDYLR-NFTQGLVEDAPDGSDASQLLHQA--EVAQ 3035
Query: 6052 ERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALS 6111
+ ++ + + ++E KL + + ++ C E+ S L LD +
Sbjct: 3036 QEFLEVKQRVNSGCVMMENKL----------EGIGQFHCRVREMFSQLADLDDELDGMGA 3085
Query: 6112 PPKEPMDMEAQLMDCQNML-------VEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQ 6164
++ +++Q+ D + L ++IE + L L G + +
Sbjct: 3086 IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNK 3145
Query: 6165 LAGKL-RRLKGSLLELQRALHD--------KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
GKL R K +L+ L K LN TA E+ E+ + T+ + +
Sbjct: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
Query: 6216 LAQARTTWTQQ---RQSSLQQ---------------------QKELEQELAEQKSLLRSV 6251
LA + +Q Q LQQ + ++E+ A +L + V
Sbjct: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
Query: 6252 ASRGEEILIQHSAAETSGDAGEKPDVLSQELG--MEGEKSSAEDQMRMKWESLHQEFSTK 6309
A R ++ E G+ D L L + E+ A + + + +
Sbjct: 3266 AQRIAQL------QEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3319
Query: 6310 QKLLQNVLEQEQEQV--LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSS 6367
QKLLQ +L+ + V L + R+ L D+ +T L+ L + E+ S
Sbjct: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAEL-------ADREKITGQLESLESRWTELLS 3372
Query: 6368 QSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAK 6424
++ ++Q + L ++ ++ S +L E++L + P T+T Q+I+
Sbjct: 3373 KAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSE---PVGTQTAKIQQQIIRH 3429
Query: 6425 DIKEMSEEMDKNKNLFSQAFP--------ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRC 6476
K + E+++ + QA + + V+ + + L R S + ++
Sbjct: 3430 --KALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKA 3487
Query: 6477 HQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEF 6536
+ + L F D + LA+ + KL++VF + + + Q A+
Sbjct: 3488 ALLDQALSNARLFGEDEVEVLNWLAE----VEDKLSSVFVKDFKQDVLHRQHADH--LAL 3541
Query: 6537 DAGIIELKRRGD------KLQVEQPSMQELSKLQD-------MYDELMMIIGSRRSGLNQ 6583
+ I+ K+ D + ++Q + +E+ +Q+ Y ++ + L Q
Sbjct: 3542 NEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQ 3601
Query: 6584 NLTLKSQYERALQDLADLLETGQEKMA--GDQKIIVSSKEEIQQLLDKHKEYFQGLESHM 6641
L ++++ ++L L +E++A G Q + E+I Q + KE + + H
Sbjct: 3602 ARQLATKFQSTYEELTGWLREVEEELATSGGQS---PTGEQIPQFQQRQKELKKEVMEHR 3658
Query: 6642 ILTET---LFRKIISFAVQKETQFHTELMAQAS------------------AVLKRAHK- 6679
++ +T + R ++ + + +L++ A+ A ++R+ +
Sbjct: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718
Query: 6680 ---RGVELEYILETWSHLDE------DQQELSRQLEVVESSIPSVGLVEENEDRLIDRI- 6729
EL ++ ET L +Q + + QL+V ++ + +++ D L
Sbjct: 3719 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRS 3778
Query: 6730 ----TLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQ---LNQLGEC------W 6776
T + K+ L E L Q + LL S + LE +NQ E W
Sbjct: 3779 EIFGTCGEEQKTVLQEKTESLIQQY-EAISLLNSERYARLERAQVLVNQFWETYEELSPW 3837
Query: 6777 LSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDR----LEFWTQQSVTVPQEL 6832
+ T + +L + + Q E L + K L+ Q P+E
Sbjct: 3838 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG 3897
Query: 6833 EMVRDHL----NAFLEFSKEVDAQSSLKSSVLSTGNQLLRL-KKVD--TATLRSELSRID 6885
EMV + N + + +EV ++ +S Q+ K++ TL + SR+
Sbjct: 3898 EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL- 3956
Query: 6886 SQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--- 6942
+ IPA +K+ + D ++ A E+ E + ++ E+ I S G
Sbjct: 3957 ----RMPPLIPAEVDKIRECISD---NKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009
Query: 6943 ---YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQ------------------- 6980
K I + L + F DI + + VL+++ +
Sbjct: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4069
Query: 6981 -DVESKRSDKTDFAEQLGAMNKSWQILQGL-----------------------------V 7010
D+ES D + +Q+ A + GL +
Sbjct: 4070 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4129
Query: 7011 TEKIQLLEGLLESWSE--------------YENNVQCLKTWFETQEKRLKQQHRIG-DQA 7055
E E L ++W E Y++ +Q + W + +L +G D
Sbjct: 4130 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4189
Query: 7056 SVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVS-SIVMSTLRELGQTWANL 7114
+V++ L + ++ + + ++ E+EK+ G +++ ++ I+ L EL W NL
Sbjct: 4190 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENL 4249
Query: 7115 DHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQ 7174
+ + L+ L + A +++ S+L L R ++G + ++V++
Sbjct: 4250 GEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHH 4309
Query: 7175 NLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSS 7234
L++D+ + +++ N+LL+ +L + L+ +N W ++L++ E+ Q
Sbjct: 4310 VLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQL 4369
Query: 7235 KALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLG 7294
++ LQ Q + + + + E + + + A +++ T + +L L
Sbjct: 4370 QSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHM----ELYSQLK 4425
Query: 7295 TVKDSLFFLHELGE-QLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
+++ L + G L + D+ + S + L Q + + ++++ L+ +
Sbjct: 4426 AKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNL 4485
Query: 7354 YETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRL 7413
F SL+ W+ AE+ L P S L+T+ ++EE K + ++ + L
Sbjct: 4486 ATEFQNSLQEFINWLTLAEQSLNIASPP-SLILNTVLSQIEEHKVFANEVNAHRDQIIEL 4544
Query: 7414 NELGYRLPL--NDKEIKRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCET 7467
++ G +L +++ ++NL W + ++ ER L + + F E +
Sbjct: 4545 DQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKK 4604
Query: 7468 WMEFLVQTEQKL--AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG 7525
+++L E L +EIS + + Q H+ FQ + +Q + + I G+ L E+
Sbjct: 4605 LIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKT 4664
Query: 7526 QV-DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSY 7584
+ +D + + L + ++W V ++ +R+ ++ + ++ + + L WL +V
Sbjct: 4665 LLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE- 4723
Query: 7585 LPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
++ V L L D + +K ++ G+ + +G++L+ ++ ++
Sbjct: 4724 PQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDT-TWVK 4782
Query: 7645 AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL--SQSLPD 7702
+L E+ +W + ++ +L LK E + LE L ++ L +LPD
Sbjct: 4783 GQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPD 4842
Query: 7703 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE 7762
E L + KE V D+ + + + A D I+ + + +++ ++E
Sbjct: 4843 DTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFE 4902
Query: 7763 ELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK--- 7819
E+ +Q++ L+E +E +EL W+ E+ + Q I + I+++K
Sbjct: 4903 EVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALI 4962
Query: 7820 ---KDYQEEIAIAQENKIQLQQMGERL------AKASHESKA-----------------S 7853
+ + EE+ Q + ++ + +R A +S++ S
Sbjct: 4963 AEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILS 5022
Query: 7854 EIEYKLGKVND---RWQHLLDLIAARVKKLKETLVAVQQL 7890
+ E K ++N RWQ + L R +KL + L +++L
Sbjct: 5023 QSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062
Score = 274 bits (701), Expect = 2e-72
Identities = 711/3993 (17%), Positives = 1533/3993 (38%), Gaps = 498/3993 (12%)
Query: 4917 LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGD 4976
L D++++ + EE+ + + +S + T + L + ++L E
Sbjct: 1204 LSDVKDKNSVFSVLDEEIAKAKVVAEQMS-----RLTPERNLDLERYQEKGSQLQERWHR 1258
Query: 4977 IQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED--AQELLQLAGNGLDVESAEENLKS 5034
+ L RQ+ L I Y W+E+ AQ+ + G D E L
Sbjct: 1259 VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQ 1318
Query: 5035 HMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVD 5094
F+ ++ + L++ ++K D E ++ + + + + G +
Sbjct: 1319 QTALFAEIERNQTKLDQCQKFSQQYSTIVK-----DYELQLMTYKAFVESQQKSPGKRRR 1373
Query: 5095 LLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNS 5154
+L A ++ R L+ T + + S +A +L E + +V
Sbjct: 1374 MLSSSDAITQEFMDLRTRYTALVTLTTQHVKYIS--------DALRRLEEEEKVVEEEKQ 1425
Query: 5155 FH-EKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW 5213
H EK+ L S L + N KAT S + + T + +Q+ + E+ +
Sbjct: 1426 EHVEKVKELLGWVSTLAR--NTQGKATSSETKES-----TDIEKAILEQQVLSEELTTKK 1478
Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLE--YHDTFVLELEQQQSALGML 5271
+ +K + + + KL S EK +E L L YHD Q Q L
Sbjct: 1479 EQVSEAIKTSQIFLAKHGHKL--SEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQL 1536
Query: 5272 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQ 5331
QT T ++ + +R L + G+ +Q+L + ++
Sbjct: 1537 AHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQ-----GRTTQQDLSALQKNQSD 1591
Query: 5332 INSVKCWVQETKEYLGNPTIEIDAQLEELQILLT--EATNHRQNIEKMAEEQKEKYLGLY 5389
+ ++ +Q +I+ +EE Q L+ E T R+ + + E+ Y
Sbjct: 1592 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQ--------Y 1643
Query: 5390 TILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLK 5449
L E ++A+ L+ + +Q +E E+SKA ++++ + K + +L +
Sbjct: 1644 EALQEET--RVAQKELEEAVTSALQ---QETEKSKA-----AKELAENKKKIDALLDWVT 1693
Query: 5450 AKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQ 5509
+ + Q T+ + E+L G + + LD ++ N Q + L K+ + HQ
Sbjct: 1694 SVGSSGGQLLTNLPGM-EQLSGASLEKGALDTT-DGYMGVN-QAPEKLDKQCEMMKARHQ 1750
Query: 5510 QTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILH 5569
+ + Q +N + A + L++ HG H
Sbjct: 1751 ELLSQQQNFILATQSAQAFLDQ-------------------HG----------------H 1775
Query: 5570 QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQD 5629
EE + + +L + E QY TS+ +E +QV L E LQ
Sbjct: 1776 NLTPEEQQMLQQKLGELKE--QYSTSLAQSEAELKQVQTLQDE--------------LQK 1819
Query: 5630 AAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV--- 5686
+D K+FE+ L++ + LE +SPE LK Q S + ++S L+
Sbjct: 1820 FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISG 1879
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI-MQAAVVQYEQYEQ 5745
Q V +++ + ++ L L+ E H+ + + + QY Q++
Sbjct: 1880 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939
Query: 5746 EMKHLQQLIEGAHREIED--KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCK 5803
LQ ++ +E S+ LQ Q++ ++L +++ +Q + L +
Sbjct: 1940 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999
Query: 5804 MLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH-PSVVMMTAGRCHTLLSPVTE 5862
+ E+EG E + +H S+ A R L + +
Sbjct: 2000 -------------DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQ 2046
Query: 5863 -ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
+S +E S + S + +S++ + + +L+ D A+ S A+
Sbjct: 2047 SQSVQESLESLLQSIGEVEQ-NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEAT 2105
Query: 5922 QEFYEPGLEP--SATA-----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS 5974
+E +E S TA KL ++ + +E L EK+ +L + L + + ++
Sbjct: 2106 REMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH---- 2161
Query: 5975 ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCE 6034
+S K++ S G P+ + + E+ + ++ E +L E LV+E
Sbjct: 2162 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL-EHLVTELSS 2220
Query: 6035 ADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADE 6094
A L +R+ +R + ++ ++E+ D Q Q L +R
Sbjct: 2221 CGFALDLCQHQ------DRVQNLRKDFTELQKTVKEREKDASSCQEQ---LDEFRKLVRT 2271
Query: 6095 LDSWLLSTKATLDTALSPPKEPM----DMEAQLMDCQNMLVEIEQKVVALSELSVHN--- 6147
WL T+ ++ PP E ++E Q+ +++L + K + E++
Sbjct: 2272 FQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSL 2326
Query: 6148 ENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD-KQLNMQGTAQEKEESDVDLTA 6206
ENL++E T +++ G + GS + H K L T + + SDV+L
Sbjct: 2327 ENLIME---ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL----TEIQCDMSDVNLKY 2379
Query: 6207 TQSPGVQEWLAQARTTWTQQRQSSLQQ-QKELEQELAEQKSLLRSVASRGEEILIQHSA- 6264
+ GV +RQ SLQ +E+ E S+L+ + S+ EE+L A
Sbjct: 2380 EKLGGV-----------LHERQESLQAILNRMEEVHKEANSVLQWLESK-EEVLKSMDAM 2427
Query: 6265 -----AETSGDAGEKPDVLSQELGMEGEK-------------SSAEDQMRMKWESLHQEF 6306
ET E EL K + Q W+ + +E
Sbjct: 2428 SSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL 2487
Query: 6307 STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS 6366
+++ + V Q Q+ S + + +K + +L L+ +
Sbjct: 2488 NSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS-----ID 2542
Query: 6367 SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI 6426
A++Q + K ++ L++ + + + T + + +
Sbjct: 2543 PNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKW 2602
Query: 6427 KEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL--LGRLSLLDSVVNQRCHQMKERLQ 6484
E++++++ + QA ++ +++++D + +G+ + S ++ + +K++L+
Sbjct: 2603 VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE 2662
Query: 6485 QILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI----EAIQQAEDGLKEFDAGI 6540
+ ++DL+ L + + + + + + EQ + +++ E + GL++ A
Sbjct: 2663 ETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAA-- 2720
Query: 6541 IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6600
D++ Q ++ + Q M+DEL + ++S +N + ++ ER L +
Sbjct: 2721 -------DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQE 2773
Query: 6601 LLETGQE--KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQK 6658
E + + +G ++IV+ E + + +E TL +++
Sbjct: 2774 NEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE-----------KRTLQNQLV------ 2816
Query: 6659 ETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLV 6718
E + H E +++ +A + S L + Q+ + VE +P +
Sbjct: 2817 ELKNHWEELSKKTA----------------DRQSRLKDCMQKAQKYQWHVEDLVPWIEDC 2860
Query: 6719 EENEDRL---IDRITLYQHL---KSSLNEYQPK--LYQVLDDGKRLLISISCSD---LES 6767
+ L +D + L L K+ LNE + + L ++L+ +LI+ S +D +
Sbjct: 2861 KAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRD 2920
Query: 6768 QLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ--QS 6825
+ + + + T ++ + LE + + +Q ++ ++ AK +LE +
Sbjct: 2921 EKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQ 2980
Query: 6826 VTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVL------STGNQLLRLKKVDTATLRS 6879
+ LE +R +VD + ++ S +QLL +V
Sbjct: 2981 ACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLE 3040
Query: 6880 ELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV--IQKDEDNI 6937
R++S ++ KL + R S++ ++ + I +D D++
Sbjct: 3041 VKQRVNS-------GCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSL 3093
Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
++ I + + +L K K+DI + + + E D +L
Sbjct: 3094 QSQI--EDVRLFLNKIHVLKLDIEASEAECRHMLE----------EEGTLDLLGLKRELE 3141
Query: 6998 AMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASV 7057
A+NK L + + LE L ++ ++ L E+ Q +G + +
Sbjct: 3142 ALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEI 3201
Query: 7058 QNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLA--LIQNKKEDVSSIVMS-TLRELGQ 7109
N Q L D ++++V+ ++ NGL LIQ+ +D + + E+
Sbjct: 3202 IN-----QQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3256
Query: 7110 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 7169
W L+ V Q L+ L + A + + S+L + ++ + + + V+ Q
Sbjct: 3257 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQ 3316
Query: 7170 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 7229
+ + LQ L+ ++ ++ + ++ + E +T L+ + RW LL + A
Sbjct: 3317 IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAA 3376
Query: 7230 QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDL 7289
+ + + +L L +++ + ++ + + E + T ++ D+
Sbjct: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436
Query: 7290 LKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQA 7349
V ++ ++G+ L + + SL ++ C++ L
Sbjct: 3437 ENHATDVHQAV----KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQ 3492
Query: 7350 GVLDYETFAKSLEALEAWIVEAEEILQG-------QDPSHS--SDLSTIQERMEELKGQM 7400
+ + F + + W+ E E+ L QD H +D + E + K +
Sbjct: 3493 ALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNV 3552
Query: 7401 LKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT 7460
+ L + G + L +++ ++ ++ SS+ + + + Q+
Sbjct: 3553 DQAIKNGQALLK-QTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 3611
Query: 7461 FLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-----QRAHELFQAEMFSRQQILHSII 7515
E+ W+ + E++LA SG EQ QR EL + E+ + +L ++
Sbjct: 3612 TYEELTGWLR---EVEEELAT--SGGQSPTGEQIPQFQQRQKEL-KKEVMEHRLVLDTVN 3665
Query: 7516 IDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKL 7575
+ LLE R+ + ++ + Q++ V QR ID+ I++ Q+Y + A+
Sbjct: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAE 3725
Query: 7576 RKWLVEVSYLPMSGLGSVPIPLQQARTLFD-EVQFKEKV-FLRQQGSYILTVEAGKQLLL 7633
W+ E M+ LG PI L+Q +T +VQ + +R + S ++
Sbjct: 3726 LAWVAETKRKLMA-LG--PIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFG 3782
Query: 7634 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL----AFLLKDWEKCEKGIADSLEKL 7689
+ + LQ + + +++++ S+ E+ +L + + WE E+ ++ +E+
Sbjct: 3783 TCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE-LSPWIEET 3841
Query: 7690 RTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISI 7749
R +L DH E+L +Q ++L ++ + +L + L ++ ++ +
Sbjct: 3842 RALIAQLPSPAIDH-EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE-LNPEEGEM 3899
Query: 7750 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV---FSEKNKELCEWLTQMESKVSQN 7806
+ E+ + + + ++ ++ R + E +++ F +K + + E L + S++
Sbjct: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
Query: 7807 GDILIEEMIEKLKKDYQE-EIAIAQENKIQ-----LQQMGERLAKASH----ESKASEIE 7856
LI ++K+++ + + A + K+Q L++ GE L S + A EI+
Sbjct: 3960 P--LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ 4017
Query: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 7916
KL ++ W+ + R K + L ++ +M++L T + + IV+D
Sbjct: 4018 DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQD-----IVHDL 4072
Query: 7917 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNL 7976
+ + +Q E I++ + G+ L +L D + E ++++ +
Sbjct: 4073 ESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEM 4132
Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAK 8036
+ W N+ ER K+E+ + ++ D DWL ++ G K
Sbjct: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192
Query: 8037 EELKKFEAFQRQVHECLTQLELINKQYRRLARE--NRTDSACSLKQMVHEGNQRWDNLQK 8094
++L + + F+ +V++ ++E +N Q + ++ + TD +++ + E W+NL +
Sbjct: 4193 DQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI-IREPLTELKHLWENLGE 4251
Query: 8095 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD---VQAKIKQLKA 8151
++ +L+ + +F+ A + ++ WLT + +L + + D ++ ++ +
Sbjct: 4252 KIAHRQHKLEGALLALGQFQHALEELMSWLTHTE-ELLDAQRPISGDPKVIEVELAKHHV 4310
Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE--------------EELDELRRYCQ 8197
+ ++ + +E + G +L+E S DA+ + ++ +E + Q
Sbjct: 4311 LKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ 4370
Query: 8198 EVFGRVERYHKK----LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8253
+ + +H + L+ L + + S L ++A L H L + +
Sbjct: 4371 STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR-EQLDTHMELYSQLKAKEE 4429
Query: 8254 SSNLSLSLAQPLRSER----SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 8309
+ N L + + R SG T SV + +W + +S + AL E
Sbjct: 4430 TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEF 4489
Query: 8310 GQDDKDFY-------------------LRGAVGLSGDH-------SALESQIRQLGKALD 8343
++F L + +H +A QI +L + +
Sbjct: 4490 QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 4549
Query: 8344 DSRFQIQQT----------------ENIIRSKTPTGPELDTSYK-------GYMKLLG-- 8378
+F Q+ E +++ G LD + K + KL+
Sbjct: 4550 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWL 4609
Query: 8379 -----------ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI--------- 8418
E S+ D +K K KE +++L G ++ T +T +
Sbjct: 4610 EDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPED 4669
Query: 8419 ------------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQL 8466
D+W+ + +++ ++ ++++ L QF L ++ WL E +L +
Sbjct: 4670 SQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAED 4729
Query: 8467 QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQ 8526
Q + D+ + K+ QK + R + + E + ++ ++ +L +
Sbjct: 4730 QPVHGDLDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 4787
Query: 8527 MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLD 8584
++ RWD VC L + L+ AL Q + F + H LL L ++ R +P D+
Sbjct: 4788 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA- 4846
Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLK 8643
+ L D HK+ M+ ++ E ++ V S M ++++ DC+ K + +I R +
Sbjct: 4847 LQSLIDTHKEFMK---KVEEKRVDVNSAVAMG-EVILAVCHPDCITTIKHWITIIRARFE 4902
Query: 8644 LLLKEVSRHIKELEKLLD--VSSSQ--QDLSSW 8672
+L +H + LE L V++++ ++L +W
Sbjct: 4903 EVLTWAKQHQQRLETALSELVANAELLEELLAW 4935
Score = 269 bits (688), Expect = 8e-71
Identities = 836/4731 (17%), Positives = 1777/4731 (37%), Gaps = 681/4731 (14%)
Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEK--ML 1228
+N T ETL L+++ L E SS Q L K S A + L+E E+ +
Sbjct: 648 QNFHTSYAETLGKLETQYCKLKETSSFRMRHLQS--LHKFVSRATAELIWLNEKEEEELA 705
Query: 1229 SNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAK 1288
++ D +N EL +E Q+ + DT A+ L L + + + A
Sbjct: 706 YDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT-----AELLSLENHPAKQTVEAY 760
Query: 1289 KRDVQQQIAQAQQ---------GEGGLPDRGHEELRKLESTLDGLERSRERQ-------- 1331
VQ Q+ +Q E + + R+LES L L+ S +R+
Sbjct: 761 SAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTS 820
Query: 1332 ----ERRIQVTLRKWERFETNKETVVRYLFQTGS-------SHERFLSFS-SLESLSSEL 1379
E +Q ++ + E+ +K +V + ++ + S + L + S++++
Sbjct: 821 LSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYR 880
Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEIPLG-------------PQNKQLLQQQAKSIKEQ 1426
+ K E + K P G P NK ++ ++ +
Sbjct: 881 QIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSY 940
Query: 1427 VKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQI 1486
K + + + T ++ W++ + + + W EK + E ++Q
Sbjct: 941 QKVMALWHQLHVNTKSLIS--WNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998
Query: 1487 KVTIQEIESKLSSIVG---LEEEAQS----FAQFVTTGESAR-----IKAKLTQIRRYGE 1534
+S L S+ LEEE ++ F + + E+ K +++++
Sbjct: 999 DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRL 1058
Query: 1535 ELREHAQCLEGTILG----------------HLSQQQKFEENLRKIQQSVSEFEDKLAVP 1578
L E+ Q + I +++Q+ +E+L++++ + K
Sbjct: 1059 RLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF 1118
Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYED 1638
+ S++ + E L + ++ + T + + V +Q+A L + YE
Sbjct: 1119 LHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEI 1178
Query: 1639 ILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQL 1698
L + + L L AHW L LS V+ + +
Sbjct: 1179 KLSQEEVVLADLSALEAHWSTLRHWLSD-------------------------VKDKNSV 1213
Query: 1699 IQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP---QIINK 1755
L E+ +K++ + S + D++ + QL ERW + +I
Sbjct: 1214 FSVLDEEIAK-----AKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQS 1268
Query: 1756 RINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
+ +Q V+ +++ L+ WI+ +TT++ +M + E
Sbjct: 1269 ELESIQEVLGDYRACHGTLIK---WIE------ETTAQQEMMK-----------PGQAED 1308
Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQ 1875
+ + L A + R Q K + C + ++ S +V+ +L L F++
Sbjct: 1309 SRVLSEQLSQQTALFAEIERN------QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVE 1362
Query: 1876 SHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY 1935
S G R++ + SD I ++ D AL + +S A
Sbjct: 1363 SQQKSPGKRRRMLSS-----------SDAITQEFMDLRTRYTALVTLTTQHVKYISDALR 1411
Query: 1936 HLKIGSSEQRTSCRATADQLCGEVERIQNLLG-----TKQSEADALAVLKKAFQDQKEEL 1990
L+ E+ + ++ VE+++ LLG + ++ A + K D ++ +
Sbjct: 1412 RLE----EEE---KVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI 1464
Query: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDV 2050
L+ EE T K KE +A++ ++F L H H+L +K K+
Sbjct: 1465 LEQQVLSEELTTK---KEQVSEAIKTS-QIF------LAKHGHKL---SEKEKK------ 1505
Query: 2051 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2110
++ ++N L + D C G + + Q L+S ++ E +
Sbjct: 1506 ----QISEQLNALNKAYHDL----------CDGSAN---QLQQLQSQLAHQTEQKTLQKQ 1548
Query: 2111 TRTTIKDQEDL-KWAF-SKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168
T + EDL W ++ A ++ Q+DL S L+K + SD ++
Sbjct: 1549 QNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL-----------SALQK-NQSDLKDLQ 1596
Query: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228
D+++ + V + +E M+ + LS ++ + R+++ Q E L
Sbjct: 1597 DDIQNRATSFATVVKDIEGFMEENQTKLSP-RELTALREKLH--------QAKEQYEALQ 1647
Query: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD-LQFIEADLMQKLEH 2287
R + KE E V + + E +L E K ++ D + + + Q L +
Sbjct: 1648 EETRVAQ--KELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 1705
Query: 2288 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347
+ +++ +L+ +T +N + E L ++ CE +K +
Sbjct: 1706 LPGMEQLSGASLEKGALDTTDGYMGVN-------QAPEKL-----DKQCEMMKAR---HQ 1750
Query: 2348 ELQSQQSN-ISSTQENLNSLCRKYHSA--ELESLGRAMTGLIKKHEAVSQLCSKTQA--- 2401
EL SQQ N I +TQ L + H+ E + + + G +K+ + S S+ +
Sbjct: 1751 ELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV 1810
Query: 2402 -SLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
+LQ+ L+K F + +EF+ W ++ + + L + L + + V +
Sbjct: 1811 QTLQDELQK-FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869
Query: 2461 SKLDAVTQEGQTLY--------AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQD 2512
L VT GQ + +I + +++++ A E + A +C + L
Sbjct: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNM 1929
Query: 2513 CASELGSFEDQHRKLNLWIHEME---ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLA 2569
+ F++ L W+ E E+ ++ + + E+ +++ L E
Sbjct: 1930 LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQV 1989
Query: 2570 ARESLDKLSQRGQLLSEEGHGAGQEGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEH 2626
E L K+++ ++ EG A + +L+ Q+L E+ Q A+ +
Sbjct: 1990 PVEKLQKVAR--DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQS 2047
Query: 2627 EALEEALQSMWFWVKAIQDRLACAE-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLN 2682
++++E+L+S+ + ++ L + S+L S ++ L + QDI K E
Sbjct: 2048 QSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATRE 2107
Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
M + + +++ V+Q +L + + + + +S+L+ ++ Q +
Sbjct: 2108 MVT----RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS 2163
Query: 2743 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE 2802
+L+Q+ME+ + + QP + F + L + + +++ L L+ +
Sbjct: 2164 GKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGF 2223
Query: 2803 KTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEE 2862
+ +D Q L+ F ++ KE+ + + + V F WL +
Sbjct: 2224 ALDLCQHQDRVQN-LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGS 2282
Query: 2863 LHRWSDMSGDSSATQKKLSKIKELIDS--------REIGASRLSR----VESLAPEVKQN 2910
+ ++ S + +K++ +K L+D EI S +E AP+ +
Sbjct: 2283 IPP-TETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGK 2341
Query: 2911 T-----------------------TASGCEL-------------MHTEMQALRA------ 2928
T T C++ +H ++L+A
Sbjct: 2342 TGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRME 2401
Query: 2929 ----------DWKQWEDSVFQTQSCLEN-----LVSQMALSEQEFSGQVAQ----LEQAL 2969
W + ++ V ++ + + V A S + F ++ Q +++
Sbjct: 2402 EVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVK 2461
Query: 2970 EQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQL------ 3023
E + LL T+ K EE+ W + E+ A Q+ + E+ S L
Sbjct: 2462 EALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR---QLEESASHLACFQAA 2518
Query: 3024 -NELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVN 3082
++L + + G + L + N L Q + + Q + + F + +Q
Sbjct: 2519 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-----KQQVQFMLKEFEARRQQHEQLNEA 2573
Query: 3083 AKITTAKCFDIPQNISEVSTSLQKIQ----EFLSESENGQHKLNMMLSKG----ELLSTL 3134
A+ D+ + S+V LQ I E + + +++ + K ELL L
Sbjct: 2574 AQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDL 2633
Query: 3135 LTKEKAKG----IQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE---------VS 3181
K +A G +Q+ ++ E K + S LE L ++K+ + +
Sbjct: 2634 SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIG 2693
Query: 3182 AEPIQDWLSKTEKMVHESSNRLYDLPAKRREQ--------QKLQSVLEEIHCY------- 3226
+ ++D L K + V L DL A R + Q+ Q + +E+ +
Sbjct: 2694 EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 2753
Query: 3227 -------EPQLNRLKEKAQQLWEGQAA---------------------------SKSFRH 3252
+L RL+ + Q+ E Q + ++ ++
Sbjct: 2754 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 2813
Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
++ +L + + LS T ++ SRL + + ++ +++L W+ D + S T D
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLD 2872
Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWAS 3372
L+S L+ +A+L+ + EK + I+ +L N+S + ++D A
Sbjct: 2873 PVQLESSLLRSKAMLN-EVEKRRSLLEILNSAADILINSS-------EADEDGIRDEKAG 2924
Query: 3373 LLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKA 3432
+ +L+ +R+F ++E + E + E+ D +
Sbjct: 2925 INQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV-EGAKHQLEIFDALGSQACS 2983
Query: 3433 KLLNEEVLSYSSLLETIEVK-------GAGMTEHYVTQLELQDL-------QERYRAIQE 3478
E++ + +L+ +E + G+ E + L Q+ + +++
Sbjct: 2984 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQ 3043
Query: 3479 RAKEAVTKSE-KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQ- 3536
R E KL + Q + R + F L ++LD + D + ++ + D++
Sbjct: 3044 RVNSGCVMMENKLEGIGQFHCRVREMFSQ-LADLDDELDGMGAIGRDTDSLQSQIEDVRL 3102
Query: 3537 ------ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
L++ +A +L + G+ R LE+L + R +
Sbjct: 3103 FLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLK----RELEALNKQCGKLTERGKARQ 3158
Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWH-EEVT 3649
Q + ++ +K + +++ AEE + + + QL K + E+V
Sbjct: 3159 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3218
Query: 3650 AYRDEVEEVGARAQEILDESHVN---SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQS 3706
+ ++++V Q ++ + + + ++ +R+ L +V ++I L+E +
Sbjct: 3219 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3278
Query: 3707 LEESESSLSSYSDWYGSTHK---NFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSL 3763
+ + +L W T + N K + + V + +KL L+ LL D + +
Sbjct: 3279 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL--LQRLLDDRKATVDM 3336
Query: 3764 LKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSD 3823
L++ +G R + E + E++ ++ + EL S LE L LAK+F +
Sbjct: 3337 LQA---EGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHE 3393
Query: 3824 KCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL 3883
+ ++ +++ ++ L E + + + Q+ ++K+L++ + +H V + G++L
Sbjct: 3394 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3453
Query: 3884 LELVQDV---TLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
L L +KID LQ+ Y ++ L+ + + + + EV WL +
Sbjct: 3454 SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAE 3513
Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA 4000
+ +L + ++ + + +Q A H A+ EEI + ++ G L+ Q
Sbjct: 3514 VEDKLSSV-FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVL 3572
Query: 4001 KLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLE 4060
+++ L G K Y+ I T+ + ++LE Q Q T ++ WL V+ +L
Sbjct: 3573 LIQEK----LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA 3628
Query: 4061 PSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQ 4120
S ++ +Q+ F+ Q++ + + + D N + + + +
Sbjct: 3629 TSG----GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLD 3684
Query: 4121 KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVK 4180
KLV N E+ K + + + + D +Q ++ + +A V++ K +
Sbjct: 3685 KLVSDAN-----EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA--WVAETKRKLM 3737
Query: 4181 -----KLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQRE-E 4234
+L+ Q + ++K + E+ + C + LQ + E
Sbjct: 3738 ALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE 3797
Query: 4235 DLQRTRDYHDCMNV--------VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQ 4286
L + + +N +V + +F ++ L+ E+ A+ + L A+ +
Sbjct: 3798 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRAL-IAQLPSPAIDHE 3856
Query: 4287 ERKYAIEDLKDQKQKMIEH----------------LNLDDKELVKEQTSHLEQRWFQLED 4330
+ + E+++ ++ + EH LN ++ E+V+E+ E + Q+++
Sbjct: 3857 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 3916
Query: 4331 LIKRK---IQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSP----PPDMAQNL 4383
++++ + +V+ ++ + + ++E E N++ L+ P D +
Sbjct: 3917 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLE----NLSSRLRMPPLIPAEVDKIREC 3972
Query: 4384 LMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQ 4443
+ D+ + ELE Q ++L + + ++ ++ + K + D + + +
Sbjct: 3973 ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKA 4032
Query: 4444 RR-----KYLNKA-LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCK 4497
R K+L+ L+EK + MA T I+ + + E + P + +QV+ +
Sbjct: 4033 RAEEREIKFLDVLELAEKFWYDMAALLTT--IKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
Query: 4498 SAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQEL 4557
+ + E+ + G +L+ E EK EV + E+ + ++++ + RL++L
Sbjct: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150
Query: 4558 EKNLVSRKHFKEDFDKACHWLKQADI--VTFPEINL-MNESSELHTQLAKYQ-NILEQSP 4613
E + + +++ WL I T P + +N + ++ +++ + +Q
Sbjct: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQI 4210
Query: 4614 EYENLLLTLQRTGQTILP-SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILA 4672
E E L G+ +L + +E D + E L L + + + +K++ A+LA
Sbjct: 4211 EMEKL----NHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266
Query: 4673 RKEYASLIE-----LT-TQSLSE-----------LEAQFLRMSKVPTDLAVEEAL--SLQ 4713
++ +E LT T+ L + +E + + + D+ +A ++
Sbjct: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
Query: 4714 DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL 4773
+L+ AG D+ + + + Q W+ ++ + + + +Q S L
Sbjct: 4327 KAGNELLESSAG-----DDASSLRSRLEAMNQCWE--------SVLQKTEEREQQLQSTL 4373
Query: 4774 EDTTSAYQEHEKMCQQLER---QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGI 4830
+ + E E +L R QL + K + +++Y L +
Sbjct: 4374 QQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQ 4433
Query: 4831 VLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4890
+L + + L D + K + + + +++S + E ++ E + + +FQ
Sbjct: 4434 LLDKGRLML---LSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQ 4490
Query: 4891 TEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE 4950
+ ++WL + L+ L L + +I + ++ EV + + L +
Sbjct: 4491 NSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQ 4550
Query: 4951 -KFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWL 5009
KF K+ + ++ S + +Q ++ R +L + + +++++ ++ DWL
Sbjct: 4551 LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIE-RGRSLDDARKRAKQFHEAWKKLIDWL 4609
Query: 5010 EDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKE 5069
EDA E +L S +E + D+ L + TL GK
Sbjct: 4610 EDA----------------ESHLDSELEISNDPDKIKLQLSKHKEFQKTLG------GK- 4646
Query: 5070 DLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
Q V +R+ R ++ T D QK + + + K
Sbjct: 4647 ---QPVYDTTIRTGRALKEK----------TLLPEDSQK----LDNFLGEVRDKWDTVCG 4689
Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
H+ EE L + + + + + +E + ++ + D V+
Sbjct: 4690 KSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF 4749
Query: 5190 Q-----RWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASK 5244
Q R ++ + + +++E++ D+ T ++++ + D + KL S + +
Sbjct: 4750 QKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVC-KLSVSKQSRLEQ 4808
Query: 5245 AELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRC 5304
A L + DT + LE A +QTL GA P E L I ++
Sbjct: 4809 A-LKQAEVFRDTVHMLLEWLSEA-----EQTLRFR--GALPDDTEA--LQSLIDTHKEFM 4858
Query: 5305 LNMQEK-VKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQIL 5363
++EK V N + E+ I ++K W+ TI I A+ EE+
Sbjct: 4859 KKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWI----------TI-IRARFEEV--- 4904
Query: 5364 LTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQS 5423
LT A H+Q +E E L +L +Q AE L + ++ I I V+
Sbjct: 4905 LTWAKQHQQRLETALSELVANAELLEELLAW---IQWAETTLIQRDQEPIPQNIDRVKAL 4961
Query: 5424 KATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAV 5483
A Q ++ + D+ + K K A +K G L +
Sbjct: 4962 IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK----SRSGGRKSLSQPTPPP 5017
Query: 5484 QKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNE 5534
L Q+ + +I +L+ QQ A R KLN A LEE E
Sbjct: 5018 MPILSQS----EAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
Score = 266 bits (679), Expect = 9e-70
Identities = 795/4586 (17%), Positives = 1743/4586 (38%), Gaps = 602/4586 (13%)
Query: 2207 DEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEE-LHSKVNDLKELT 2265
D E W + +M E +L + ELL + ++++N AL EE L N L+
Sbjct: 400 DVEEEWGKLII-EMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADA 458
Query: 2266 KNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE 2325
+LE+ +Q E+D++ ++ + + + L+ ++ + ++ ++++
Sbjct: 459 AHLESGQPVQ-CESDVIMYIQECEGLIRQLQVDLQILRDENYYQ---LEELAFRVMRLQD 514
Query: 2326 SLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL 2385
L+ + E +K EL S +++T L + HS+ + MT
Sbjct: 515 ELVTL-RLECTNLYRKGHFTSLELVPP-STLTTTHLKAEPLTKATHSSSTSWFRKPMT-- 570
Query: 2386 IKKHEAVSQLCSKTQASLQESLEK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
+ E V+ S+ + +L+ E + E MQ E ++ D +E
Sbjct: 571 --RAELVAISSSEDEGNLRFVYELLSWVEEMQ-----------MKLERAEWGNDLPSVEL 617
Query: 2445 KLHDLQNILDSVSD-GQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQC 2503
+L Q+I SV + G S +A EG+ +S+ +S E + K ++ +
Sbjct: 618 QLETQQHIHTSVEELGSSVKEARLYEGK-----MSQNFHTSYAETLGKLETQYCKLKETS 672
Query: 2504 LKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMF 2563
+ LQ L F + +W++E EE + ++ +I K+N ++ M
Sbjct: 673 SFRMRHLQS----LHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTM- 727
Query: 2564 LGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVAL 2623
EL ++ L +LLS E H A Q S + Q+ L+ K+ + +
Sbjct: 728 --ELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAV---QSQLQWMKQLCLCVEQHV 782
Query: 2624 QEHEA----------LEEALQSMWFWVK----------------AIQDRLACAESTLGSK 2657
+E+ A LE L+++ +K +QD + E + SK
Sbjct: 783 KENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSK 842
Query: 2658 DTLEKRLSQIQDIL---------LMKGEGEVK-------LNMAIGKGEQALRSSNKE--- 2698
++ + + + I+ ++K VK + + I K ++ + N +
Sbjct: 843 SSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902
Query: 2699 --------GQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQW-- 2748
+ ++ + + D + + + + + V++ W+ L W
Sbjct: 903 WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962
Query: 2749 -MESVD----QKIEHPLQPQPGLKEKFV--LLDHLQSILSEAEDHTRALHRLIAKSRELY 2801
+ +D +E PG + + L H + L ++ D L + + L
Sbjct: 963 LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSV-----LFSVADRLR 1017
Query: 2802 EKTEDESFKDTAQEELKTQFNDIM--TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSA 2859
+ E E+ K Q +K+ N+ TVAK + +++ I Y V + L S+
Sbjct: 1018 LEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASS 1077
Query: 2860 KEELHRWSDMS---GDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916
+ + W D + + TQ+ L +++ +D+ + + Q+ ++S
Sbjct: 1078 RTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF---------LHQSPSSSSV 1128
Query: 2917 ELMHTEMQAL--RADWKQWEDSVF----QTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
+ +E+ L + D +V+ +T + + L + + +++Q E L
Sbjct: 1129 PTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLA 1188
Query: 2971 QFSALLKTWA---QQLTLLEGKNT-----DEEIVEC---------------------WHK 3001
SAL W+ L+ ++ KN+ DEEI + K
Sbjct: 1189 DLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEK 1248
Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNK 3061
G ++ + + + E +S+L + D G + I+E G
Sbjct: 1249 GSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAED 1308
Query: 3062 EQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEV----STSLQKIQEFLSESENG 3117
++L ++ + F + + + +C Q S + L + F+ +
Sbjct: 1309 SRVLSEQLSQQTALFAE-IERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKS 1367
Query: 3118 QHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKD 3177
K MLS + ++ + + A VT + K L + E E K+ ++
Sbjct: 1368 PGKRRRMLSSSDAITQEFMDLRTR-YTALVTLTTQHVKYISDALRRLE---EEEKVVEEE 1423
Query: 3178 FEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKE-- 3235
+ E +++ L + + + ++ +E ++ + E +L KE
Sbjct: 1424 KQEHVEKVKELLGWVSTLARNTQGKA--TSSETKESTDIEKAILEQQVLSEELTTKKEQV 1481
Query: 3236 ----KAQQLWEGQAASKSFRHRVSQLSSQYLALS----NLTKEKVSRLDRIVA------- 3280
K Q++ + K Q+S Q AL+ +L ++L ++ +
Sbjct: 1482 SEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTE 1541
Query: 3281 ------EHNQFSLGIKELQDWMTDAIHMLDSYCHPTS--DKSVLDSRTLKLEALLSVKQE 3332
+ N +++L W+ A L + T+ D S L L+ L Q
Sbjct: 1542 QKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQN 1601
Query: 3333 KEIQMKMIVTRGESVLQNT----SPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE--- 3385
+ +V E ++ SP + ++++L K+ + +L + +LE
Sbjct: 1602 RATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAV 1661
Query: 3386 -GALSKWTSYQDGVRQFS----------GWMDSMEA-------NLNESER---------- 3417
AL + T ++ + W+ S+ + NL E+
Sbjct: 1662 TSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGA 1721
Query: 3418 -----------QHAELRDKTTMLGKAK---LLNEE---VLSYSSLLETIEVKGAGMT--E 3458
Q E DK + KA+ LL+++ +L+ S ++ G +T E
Sbjct: 1722 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 1781
Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY 3518
+ Q +L +L+E+Y +++ + + + L Q++ +D K FE WL + +++L+
Sbjct: 1782 QQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENM 1841
Query: 3519 -----------SVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQA 3567
S+L+ E + +L+ GQ +L+ +E PS I
Sbjct: 1842 HKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNL 1901
Query: 3568 EDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP--RT 3625
L+ + + A + + + N ++ + + + W++ E V
Sbjct: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961
Query: 3626 RRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL--------DESHVNSRMGC 3677
S+ + QL K+ EE+ ++ VE++ A++I+ D HV
Sbjct: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE---- 2017
Query: 3678 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3737
+ S +Q+L + E+ L++ I + + SL S G +N + ++
Sbjct: 2018 TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLE--GKQVSS 2075
Query: 3738 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQL 3797
+ + ++ + L T L +D+ + S L++ RE R ++ + A L+ ++ + ++
Sbjct: 2076 LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRF 2135
Query: 3798 KELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLS 3857
++L +++ +L+K L A+ F L Q++ +L +P ++ Q+
Sbjct: 2136 EQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQ 2195
Query: 3858 ----KYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEH 3913
+ + Q+ + + E V + G A L+L Q +D++ L+ D+ +L KE
Sbjct: 2196 ELNLEMEDQQENLDTLEHLVTELSSCGFA-LDLCQH---QDRVQNLRKDFTELQKTVKER 2251
Query: 3914 VFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEI 3973
+ + +++ ++ +KWL + G + P + S + + +Q+ H K+++++
Sbjct: 2252 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSI--PPTETSMSAKELEKQIEHLKSLLDDW 2309
Query: 3974 AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI------------- 4020
A + + KG +L + + + L S ++
Sbjct: 2310 ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2369
Query: 4021 --CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIK---- 4074
S Y+ L L + RQ++LQ + V + Q S+ E +K
Sbjct: 2370 CDMSDVNLKYEKLGGVLHE---RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDA 2426
Query: 4075 -----QVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNL- 4128
+ + +A E + +L A ++ + IQ+ ++ + LV N
Sbjct: 2427 MSSPTKTETVKAQAESNKAFL-----------AELEQNSPKIQKVKEALAGLLVTYPNSQ 2475
Query: 4129 -TQGWEEIKHLKSELW-----------IYLQDADQQLQNMKRRHSELE------------ 4164
+ W++I+ + W L+++ L + S+L
Sbjct: 2476 EAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGV 2535
Query: 4165 ---LNIAQNMVS----QVKDFVKKLQSKQASVNTIIEKVNKL------TKKEESPEHKEI 4211
L+I NM++ QV+ +K+ ++++ + E + S KE+
Sbjct: 2536 LGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKEL 2595
Query: 4212 NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDA--- 4268
+N +W++L + N+ Q ++ + ++ Y + +++ EK L+ A
Sbjct: 2596 QSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE---LLQDLSEKVRAVGQRLSVQSAIST 2652
Query: 4269 --ESTAVHLEALKKLALALQERKYAIED---LKDQKQKMIEHLNLDDKELVKEQTSHLEQ 4323
E+ LE ++ L++ + +++ L D+ +I L D+ + +T L
Sbjct: 2653 QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 2712
Query: 4324 RWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNL 4383
+ LEDL +I L Q F EL W +++Q A+ S + Q+
Sbjct: 2713 Q--GLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770
Query: 4384 LMDHLAICSELEAKQMLLKSLIKDADRVMADLGL-NERQVIQKALSDAQSHVNCLSDLVG 4442
L ++ L + ++ + + ++ + E++ +Q L + ++H LS
Sbjct: 2771 LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTA 2830
Query: 4443 QRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKS---- 4498
R+ L + + ++ V I+ + K M + L P + + K+
Sbjct: 2831 DRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAK-MSELRVTLDPVQLESSLLRSKAMLNE 2889
Query: 4499 --AQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKL----QELQSVYDSVLQKCSH 4552
+ SL N + E ++ EK+ + + +ELQ+ S L++ +
Sbjct: 2890 VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS-LEEMTQ 2948
Query: 4553 RLQE-------LEKNLVSRKHFKEDFD----KACHWLKQADIVTFPEINLMNESSELHTQ 4601
RL+E +EK + KH E FD +AC K + + + L ++
Sbjct: 2949 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS-NKNLEKLRAQQEVLQALEPQVDYL 3007
Query: 4602 LAKYQNILEQSP---EYENLLLTLQRTGQTILPSLNEVDHS--YLSEKLNALPRQFNVIV 4656
Q ++E +P + LL + Q L V+ + KL + QF+ V
Sbjct: 3008 RNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI-GQFHCRV 3066
Query: 4657 ALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKV---PTDLAVEEALSLQ 4713
++ F ++ + ++ T S++E L ++K+ D+ EA
Sbjct: 3067 ---REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA---- 3119
Query: 4714 DGCRAILDE-----VAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHL---VTLYHRLKRQ 4765
CR +L+E + GL ++ LN++ G+ Q L L Y +LK
Sbjct: 3120 -ECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG- 3177
Query: 4766 TEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV----NEETLPAEEKLKMYHSL 4821
L D T+A +E E + + +++ + ++ + E+ P + KL+ + L
Sbjct: 3178 -------LNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGL 3230
Query: 4822 A-GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECE 4880
G +Q +G + H ++ L + + + + +
Sbjct: 3231 GQGLIQSAG-----------------KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQ 3273
Query: 4881 SRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRI 4940
++ FQ + L WL + ++ + ++ +I++ ++ Q +
Sbjct: 3274 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3333
Query: 4941 MNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL---RTRQATLTEIYSQCQR 4997
++ L E + ++ EL AD E +L L+ E L RQ L +I ++
Sbjct: 3334 VDML-QAEGGRIAQSAEL--ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQ 3390
Query: 4998 YYQVFQAANDWLE-DAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLV 5056
+++ + +D+L ++L G ++ + H + E+ ++ ++H V
Sbjct: 3391 FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHK---ALEEDIENHATDVHQAV 3447
Query: 5057 ---ATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEV 5113
+L L P + L +K+ SL+ R + + LL + + + + EV
Sbjct: 3448 KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEV 3507
Query: 5114 IELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTG 5173
+ + + E KLS +K + ++H AL +E+IV ++ Q K G
Sbjct: 3508 LNWLAEVEDKLSSV-FVKDFKQDVLHRQHADHLAL-------NEEIVNRKKNVDQAIKNG 3559
Query: 5174 NDASKATLSRSMTTVWQ-------RWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEM 5226
K T + + + R+ + + + LE A T F + ++ T
Sbjct: 3560 QALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 3619
Query: 5227 IDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPT 5286
+ +++++L S + + ++ + E+ + + L + + + ++L+ P
Sbjct: 3620 LREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLE--LVPW 3677
Query: 5287 PGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKE-- 5344
E L + ++ ++ + + + + ++ + E ++ WV ETK
Sbjct: 3678 RARE-GLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 3736
Query: 5345 -YLGNPTIEID---AQLEELQILLTEATNHRQNIEKMAEEQKEKY----LGLYTILPSEL 5396
LG +E D AQL+ + + H+ +++++ + E + T+L +
Sbjct: 3737 MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 3796
Query: 5397 SLQLAEVALDLKIRDQIQDKIKE----VEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5452
+ + + + +++ V Q T +ELS I++ + L L
Sbjct: 3797 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE-TRALIAQLPSPAIDH 3855
Query: 5453 DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI 5512
+ + Q + + + L E + + +L + E N + G+ + +K K ++ Q
Sbjct: 3856 EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK 3915
Query: 5513 RQAENRLSKLNQAAS---HLEEYNEMLELILKWIEK-AKVLAHGTIAWNSASQLREQYIL 5568
+ R L++A S + E+++ +E +L+ +E + L + ++RE
Sbjct: 3916 EEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISD 3975
Query: 5569 HQTLLEESKEIDSELEAMTEKLQYL-------TSVYCTEKMSQQVAELGRETEELRQMIK 5621
+++ E +++ EA+ + + L +++ ++ ++ E+++ +
Sbjct: 3976 NKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4035
Query: 5622 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQ---ATLTSPEVGRLSLKEQLSHRQHLLSE 5678
R D + +KF ++ L ++ Q L SP + +K+Q+ + + E
Sbjct: 4036 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE 4095
Query: 5679 MESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVV 5738
+ L +++ +++ + L + + + L T ++ ++ A+
Sbjct: 4096 TDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQ 4155
Query: 5739 QYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQI--A 5796
QY+ ++ + ++ ++ P +++ ++ Q++ +E K++ YQ+QI
Sbjct: 4156 AAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQIEME 4213
Query: 5797 SLNSKCKMLTMKAKHAT----MLLTVTEV--------EGLAEGTEDLDGELLPTPSAHPS 5844
LN + +++ KA T + +TE+ E +A L+G LL +
Sbjct: 4214 KLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHA 4273
Query: 5845 VVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSA 5904
+ + + HT EE +++ P++ + ++A + L
Sbjct: 4274 LEELMSWLTHT----------EELLDAQ----------RPISGDPKVIEVELAKHHVLKN 4313
Query: 5905 ERLQTDAAKIHPSTSASQEFYEPGLEPSAT---AKLGDLQRSWETLKNVISEKQRTLYEA 5961
+ L A + A E E A+ ++L + + WE++ E+++ L
Sbjct: 4314 DVL-AHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQST 4372
Query: 5962 LERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMDEILMLQDEIN 6018
L++ Q + ++ ++ +E +LS S G PE+ Q+ H L ++ ++ N
Sbjct: 4373 LQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYN 4432
Query: 6019 ELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEE 6078
+L L+S D + ++ +L ++ + K ++ LEE LN E
Sbjct: 4433 QLLDKGRLMLLSRD---DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEF 4489
Query: 6079 QRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6138
Q Q E +WL + +L+ A SPP + +L +IE+ V
Sbjct: 4490 QNSLQ----------EFINWLTLAEQSLNIA-SPPS---------LILNTVLSQIEEHKV 4529
Query: 6139 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL--KGSLLELQRALHDKQLNMQGTAQE 6196
+E++ H + ++ E +Q +L+ L K ++ ++ L Q + Q
Sbjct: 4530 FANEVNAHRDQII---------ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 4580
Query: 6197 KEESDVDLTATQSPGVQEWLAQAR-TTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRG 6255
E L + Q A + W + +S L + E E++ ++ S+
Sbjct: 4581 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL----DSELEISNDPDKIKLQLSKH 4636
Query: 6256 EEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED----QMRMKWESLHQEFSTKQK 6311
+E + D + +E + E S D ++R KW+++ + +Q
Sbjct: 4637 KEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQH 4696
Query: 6312 LLQNVL--EQEQEQVLYSRPNRLLSGVPLYKGDVPTQ-DKSAVTSLLDGLNQAFEEVSSQ 6368
L+ L + L + + L P D P D V +L+D ++ F++ +
Sbjct: 4697 KLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDA-HKVFQKELGK 4755
Query: 6369 SGGAKRQSIHLEQKLYDGVSATSTWL 6394
G + ++L + +TW+
Sbjct: 4756 RTGTVQVLKRSGRELIENSRDDTTWV 4781
Score = 223 bits (568), Expect = 7e-57
Identities = 733/3955 (18%), Positives = 1495/3955 (37%), Gaps = 630/3955 (15%)
Query: 4919 DIQEEIRKIQIHQEEVQSSLR-----------IMNALSHKE---KEKFTKAKELISADLE 4964
D++EE K+ I E + SLR I N + + +EK T AK + AD
Sbjct: 400 DVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAA 459
Query: 4965 H-SLAELSELDGDIQEALRTRQATLTEIYSQCQ-----RYYQVFQAANDWLEDAQELLQL 5018
H + + + D+ ++ + + ++ Q YYQ+ + A + EL+ L
Sbjct: 460 HLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTL 519
Query: 5019 AGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL 5078
+E K H F S E S L H L + + +
Sbjct: 520 R-----LECTNLYRKGH--FTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRA 572
Query: 5079 ELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMND---TEKKLSEFSLLKTS-- 5133
EL + S D G + + + W + + + E E ND E +L + TS
Sbjct: 573 ELVAISSSEDEGNLRFVYELLS--WVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE 630
Query: 5134 --SSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQR 5191
S E +L E K + S+ E + LE + +L++T +
Sbjct: 631 ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSS----------------- 673
Query: 5192 WTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLL 5251
R+R + Q K + A E N K ++ E+ D SA++
Sbjct: 674 -FRMRHL-QSLHKFVSRATAELIWLNEKEEE--ELAYDWSDNNSNISAKR---------- 719
Query: 5252 EYHDTFVLELEQQQSALGMLRQ--QTLSMLQDGAAPTPGEEPPLMQ-EITAMQDRCLNMQ 5308
Y +ELE++Q L+ + LS+ A T +Q ++ M+ CL ++
Sbjct: 720 NYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVE 779
Query: 5309 EKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEAT 5368
+ VK N Q D +E+ + +++ ++ ++Y + + + L L+ LL ++
Sbjct: 780 QHVKENTAYF-QFFSDARELESFLRNLQDSIK--RKY----SCDHNTSLSRLEDLLQDSM 832
Query: 5369 NHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQ 5428
+ ++ + + K L V +SK Q
Sbjct: 833 DEKEQLI----QSKSSVASL-------------------------------VGRSKTIVQ 857
Query: 5429 ELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLE 5488
R + K+ ++ + + K D+ VL + K++ + +
Sbjct: 858 LKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVIS-PTGNEAMVP 916
Query: 5489 QNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEM---LELILKW-IE 5544
L P K ++ +Q+ ++ +L+ L +N + L+L+ W +E
Sbjct: 917 SVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLE 976
Query: 5545 KAKVLAHGTIAWNSASQLREQYILH-QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMS 5603
K + A G Q+ + H + L++S+ DS L ++ ++L+ V +
Sbjct: 977 KLRSSAPG-----ECHQIMKNLQAHYEDFLQDSR--DSVLFSVADRLRLEEEVEACKARF 1029
Query: 5604 QQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRL 5663
Q + + ++ + K+ + L++ ++++E + K +L ++ + + L
Sbjct: 1030 QHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNAL 1089
Query: 5664 SLKEQLSHRQHLLSEMESLKPKVQAVQL-CQSALRIPEDVVASLPLCHAALRLQEEASRL 5722
+ EQ +H +++ L+ + AV + C S L Q +S
Sbjct: 1090 RIAEQ----EHTQEDLQQLRSDLDAVSMKCDSFLH------------------QSPSSSS 1127
Query: 5723 QHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHE 5782
T + N++ ++M H+ L +++ V +IQ+ + + +E
Sbjct: 1128 VPTLRSELNLLV----------EKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYE 1177
Query: 5783 ELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH 5842
IK QE++ + + ++A +T+ +++V+ LD E+
Sbjct: 1178 -----IKLSQEEVVLAD----LSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVA 1228
Query: 5843 PSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQAL 5902
+ +T R L E E+G+ + + S+ + + Y+A
Sbjct: 1229 EQMSRLTPERNLDL-----ERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRAC 1283
Query: 5903 SAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEK---QRTLY 5959
+ K T+A QE +PG + V+SE+ Q L+
Sbjct: 1284 HGTLI-----KWIEETTAQQEMMKPGQAEDS---------------RVLSEQLSQQTALF 1323
Query: 5960 EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINE 6019
+ER Q D Q S + I + E Q+ ++A ++ ++
Sbjct: 1324 AEIERNQTKLDQCQKFSQQYSTIV----------KDYELQLMTYKAFVE---------SQ 1364
Query: 6020 LQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQ 6079
+S + S +A E + L++ T L + S + LEE EE+
Sbjct: 1365 QKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEE------EEK 1418
Query: 6080 RQEQALQRYRCEADELDSWL--LSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKV 6137
E+ Q + + EL W+ L+ S KE D+E +++ Q + E+ K
Sbjct: 1419 VVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKK 1478
Query: 6138 VALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK 6197
+SE ++ + L H E E+ +++ L L +A HD
Sbjct: 1479 EQVSE-AIKTSQIFLAKHGHKLSEKEK-----KQISEQLNALNKAYHDL----------- 1521
Query: 6198 EESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQ-QQKELEQELAEQKSLLRSVASRGE 6256
D +A Q +Q LA Q Q +LQ QQ Q+L + L S + E
Sbjct: 1522 ----CDGSANQLQQLQSQLAH------QTEQKTLQKQQNTCHQQLED----LCSWVGQAE 1567
Query: 6257 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 6316
L H T D LS + + +D ++ + S F+T K ++
Sbjct: 1568 RALAGHQGRTTQQD-------LSALQKNQSDLKDLQDDIQNRATS----FATVVKDIEGF 1616
Query: 6317 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 6376
+E+ Q ++ P L T+L + L+QA E+ A ++
Sbjct: 1617 MEENQTKL---SPREL-------------------TALREKLHQAKEQYE-----ALQEE 1649
Query: 6377 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 6436
+ QK ++EE + T+ L +ETE + AK++ E +++D
Sbjct: 1650 TRVAQK-------------ELEEAV---TSALQQETE-----KSKAAKELAENKKKIDAL 1688
Query: 6437 KNLFSQAFPENGD---NRDVIEDTLGCLL--GRLSLLDSV--VNQ-------RCHQMKER 6482
+ + G N +E G L G L D VNQ +C MK R
Sbjct: 1689 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR 1748
Query: 6483 LQQILNFQNDLKVLFTS----LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
Q++L+ Q + + S L + + + + + +Q + E E Q L + +A
Sbjct: 1749 HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKE---QYSTSLAQSEA 1805
Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDL 6598
+ +++ D+LQ +Q+ + + + + + G + TL S +R
Sbjct: 1806 ELKQVQTLQDELQ---KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS 1862
Query: 6599 ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQK 6658
D++ GD + + S Q++LD + +G E I L + + A ++
Sbjct: 1863 EDVISH-----KGDLRFVTISG---QKVLDMENSFKEGKEPSEI--GNLVKDKLKDATER 1912
Query: 6659 ETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV--G 6716
T H+ + + G L +L + L ++ E+++ +
Sbjct: 1913 YTALHS-----------KCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961
Query: 6717 LVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLL-ISISCSDLESQLNQLGEC 6775
V + L +++ + L+ L E+Q + ++ + ++ I + + + +
Sbjct: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2021
Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE-- 6833
LS+ +S L ++L+ I QS ++ LE Q V Q LE
Sbjct: 2022 ILSHFQSLSYSLAERSSLLQK----------AIAQSQSVQESLESLLQSIGEVEQNLEGK 2071
Query: 6834 --------MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRID 6885
++++ L ++ +++ Q KSS+ +T + R + +T + L
Sbjct: 2072 QVSSLSSGVIQEALATNMKLKQDIARQ---KSSLEATREMVTRFMETADSTTAAVLQG-- 2126
Query: 6886 SQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA 6945
+ V ++ QL + + ++ +++ + E++ K + ++N A
Sbjct: 2127 --------KLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA 2178
Query: 6946 --------IHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
I + Q+ + +++ +Q +D + V ++SS D + L
Sbjct: 2179 SGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNL- 2237
Query: 6998 AMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASV 7057
K + LQ V E+ + E E+ V+ + W + E + +
Sbjct: 2238 --RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2295
Query: 7058 QNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHM 7117
+ ++ + L D +K VE+I G +L +++M Q
Sbjct: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSL--------ENLIMEITAPDSQ-------- 2339
Query: 7118 VGQLKILLKSVLDQWSSHKVAFDKINSY-----LMEARYSLS----RFRLLTGSLEAVQV 7168
G+ +L SV S +N Y L E + +S ++ L G L Q
Sbjct: 2340 -GKTGSILPSVGSSVGS-------VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2391
Query: 7169 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK---EVNMRWNNLLE 7225
+ + N +++ K+ S+ ++ ++LK + T T T+K E N + LE
Sbjct: 2392 SLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE 2451
Query: 7226 EIAEQLQSSKALL----------QLWQRYKDYSKQCASTVQQQED----RTNELLKAATN 7271
+ + ++Q K L Q + +K ++ S ++ + R +L ++A++
Sbjct: 2452 QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511
Query: 7272 K---DIADDEVATWIQDCNDLLKGLGTV----------KDSLFFLHELGEQLKQQVD--- 7315
A+ ++ W+ + ++ LG + K + F+ + E +QQ +
Sbjct: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLN 2571
Query: 7316 -------------ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLE 7362
+ + S +Q + S++Q L L + + + ++ + + L+
Sbjct: 2572 EAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ 2631
Query: 7363 ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN-------- 7414
L + + L Q S I + E +K Q+ + S + DL++L+
Sbjct: 2632 DLSEKVRAVGQRLSVQ--------SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 2683
Query: 7415 ---ELGYRLP---LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF---LEKC 7465
EL + L D+ KR++ + + +R ++LQ+ L Q F ++
Sbjct: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 2743
Query: 7466 ETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL-EQ 7524
TW++ Q++Q IS + L Q + +E FQ + I+ +G+ LL
Sbjct: 2744 RTWLDDK-QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 2802
Query: 7525 GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSY 7584
+++ +L L N W+ + ++ R+ + +++ Q+Y+ E L W +E
Sbjct: 2803 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPW-IEDCK 2861
Query: 7585 LPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
MS L P+Q +L +V R+ S + + + +L+++ E ++
Sbjct: 2862 AKMSELRVTLDPVQLESSLLRSKAMLNEVEKRR--SLLEILNSAADILINSSEADEDGIR 2919
Query: 7645 AELAEIQ-------EKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS 7697
E A I E+ ++ + LEE ++L + ++ EK + + +L F S
Sbjct: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 2979
Query: 7698 QSLPDHH-EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 7756
Q+ + + E+L A+Q + LE V + + TQ L++D D S L + E+
Sbjct: 2980 QACSNKNLEKLRAQQEVLQALEPQV-DYLRNFTQ-GLVEDAPDG----SDASQLLHQAEV 3033
Query: 7757 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI------- 7809
Q+++ E+ +++ + +L F + +E+ L ++ ++ G I
Sbjct: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSL 3093
Query: 7810 --------LIEEMIEKLKKDYQEEIA-----IAQEN-------KIQLQQMGERLAKASHE 7849
L I LK D + A + +E K +L+ + ++ K +
Sbjct: 3094 QSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTER 3153
Query: 7850 SKA--SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESE 7907
KA ++E LG+V D ++ L K L + A ++ + + T + I +
Sbjct: 3154 GKARQEQLELTLGRVEDFYRKL--------KGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
Query: 7908 LAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD 7967
LA ++ + +Q KL + L + + + S G DCD + + +
Sbjct: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ-SAG------------KDCDVQGLEHDME 3252
Query: 7968 SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS 8027
I + RW + +R +++E KF D WL +E A
Sbjct: 3253 EI-------NARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKP 3305
Query: 8028 SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 8087
Y V K ++++ + QR + + ++++ + R+A+ + +
Sbjct: 3306 PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 3365
Query: 8088 RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE--CDVQAK 8145
RW L + + ++L+ + ++F + I +L+ + +L N E +Q +
Sbjct: 3366 RWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ 3425
Query: 8146 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 8205
I + KA +++I + + Q + G+ L + P + ++ E++D L+ E+ R R
Sbjct: 3426 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3485
Query: 8206 YHKKL------IRLPLPDDEHDLSDRELELED---SAALSDLHW---HDRSADSLLSPQP 8253
L RL +DE ++ + E+ED S + D H + AD L +
Sbjct: 3486 KAALLDQALSNARL-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 3544
Query: 8254 SSNLSLSLAQPLRSERS--GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ 8311
N ++ Q +++ ++ + T V I + D D+ S+AL + ++ Q
Sbjct: 3545 IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ 3604
Query: 8312 DDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK 8371
F + L +R++ + L S Q E I P+ K
Sbjct: 3605 LATKF--------QSTYEELTGWLREVEEELATSGGQSPTGEQI--------PQFQQRQK 3648
Query: 8372 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8431
K + E +D+V + L E L + + + ++++L+ +
Sbjct: 3649 ELKKEVMEHRLVLDTVNEVSRALLE----LVPWRAREGLDKLVSDANEQYKLVSDTIGQR 3704
Query: 8432 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKA 8491
+ +Q+ QQ+ ++ AW+ +T+ +L L + L D T +LQ++K +
Sbjct: 3705 VDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID-I 3763
Query: 8492 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 8551
+ H+ ++ + S F ++ LQ++ + +++ + L E L+ A +
Sbjct: 3764 IRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVL 3823
Query: 8552 CQGFHEMSHGLLLMLENIDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVA 8610
F E L +E + I + S +D E L+ +++ Q++ + E + +
Sbjct: 3824 VNQFWETYEELSPWIE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHID 3880
Query: 8611 SLQDMSCQLL-VNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 8664
L + QL +N E + +E EK N + +EV + L++ + S+
Sbjct: 3881 KLLKIGPQLKELNPEEGEMVE--EKYQKAENMYAQIKEEVRQRALALDEAVSQST 3933
Score = 218 bits (556), Expect = 2e-55
Identities = 155/450 (34%), Positives = 233/450 (51%), Gaps = 70/450 (15%)
Query: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
R+ DE++ VQK+TFTKW+N HL K + ++DL+ED++DG L++LLEVLSG KLP E+
Sbjct: 71 RVADERDRVQKKTFTKWVNKHLMKVRKH--INDLYEDLRDGHNLISLLEVLSGIKLPREK 128
Query: 80 GRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELT 139
GR R H + N+ AL FL+ R++KLVNI + DI DG P + LGL+WTIIL+FQI ++
Sbjct: 129 GRM--RFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI- 185
Query: 140 SNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE 199
+S E+ +K K LL W Q TGI+
Sbjct: 186 ------------------YISGESGDMSAKEK------------LLLWTQKVTAGYTGIK 215
Query: 200 VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPE 259
+F W G F+++IH RP+LVD+E V+ +SNRENLE AF +AE LG+ RLLD E
Sbjct: 216 CTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAE-RLGVTRLLDAE 274
Query: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
DVDV PDEKS++TYV+ +P + +G E+ + + + V +
Sbjct: 275 DVDVPSPDEKSVITYVSSIYDAFPKVPEGG-EGISATEVDSRWQEYQSRVDS-------- 325
Query: 320 FKEMKVWIEQFERDLTRAQMVESNLQDK--YQSFKHFR----VQYEMKRKQIEHLIQPLH 373
+ WI+Q ++ ++ ++ K Y + HF+ + E ++ +IE L + L
Sbjct: 326 ---LIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLE 382
Query: 374 ---RDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSL-PAPLGTIGAWLYRAEVALREEI 429
G++ L Q + +L ++ +KSL PA + R E+ L+
Sbjct: 383 VWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPA--------VERLELLLQIAN 434
Query: 430 TVQQVHEETANTIQRKLEQHKDLLQNTDAH 459
+Q A + KL K+ LQ AH
Sbjct: 435 KIQ----NGALNCEEKLTLAKNTLQADAAH 460
Score = 199 bits (505), Expect = 1e-49
Identities = 435/2542 (17%), Positives = 998/2542 (39%), Gaps = 243/2542 (9%)
Query: 503 MEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 562
+++LE K +L + S K+ E+V+ ++ +F+ EQ Q
Sbjct: 2411 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAE---LEQNSPKIQK 2459
Query: 563 LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTV 622
+K+ + + +EAEN K E ++W + + + LEE S+ +
Sbjct: 2460 VKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 2519
Query: 623 ASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIE 669
+ L+ WL + E MLN + + + QQH +N+A ++
Sbjct: 2520 SQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT 2579
Query: 670 TCDE--MVSRDLKQQLLLLNGRWRELFMEV-KQYAQADEMDRMKKEYTDCVVTLSAFATE 726
+ + + ++++L +N +W EL ++ + +Q D+ +Y + + LS
Sbjct: 2580 GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRA 2639
Query: 727 AHKKLSEPLEVSFM--NVKLLIQDLEDIEQRVPVMDAQYK----IITKTAHLITKESPQE 780
++LS +S VK +++ +I + +D + K + + + LI ++ ++
Sbjct: 2640 VGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 2699
Query: 781 EGKEMFAT----MSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 836
E K+ T + L++ L +QQ +EL + K
Sbjct: 2700 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCP 2759
Query: 837 IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 896
I LER QS ++ Q+ L ++ ++ +G L +V ++
Sbjct: 2760 ISAKLER-LQSQLQENEEFQKSL--NQHSGSYEVIVAEGES------LLLSVPPGEEKRT 2810
Query: 897 LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKG-- 954
LQ Q+ ++ ++ + KKT D + ++ + +K++ +L + + + E
Sbjct: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 2870
Query: 955 -DPEEL---LRRHTEFFSQLDQRVLNAFLKACDELTDIL---PEQEQQGLQEAVRKLHKQ 1007
DP +L L R +++++R + L+ + DIL E ++ G+++ +++
Sbjct: 2871 LDPVQLESSLLRSKAMLNEVEKR--RSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
Query: 1008 WKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD 1067
+ E L+ E + L +E ++++ EG+ K F
Sbjct: 2929 MDAVTEELQAKTGSLE---EMTQRLREFQESFKNIEKKV-----EGA----KHQLEIFDA 2976
Query: 1068 KGPHHLCEKRLQLIEELCVKLPVRDP------------VRDTPG------------TCHV 1103
G K L+ + L +P V D P
Sbjct: 2977 LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQ 3036
Query: 1104 TLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV 1163
E++ ++S + + + R E S ++ + +L G+ DT +
Sbjct: 3037 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT---DSL 3093
Query: 1164 KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSE 1223
+ +E++R L K + L +SE E + +E L L+ L E
Sbjct: 3094 QSQIEDVR---------LFLNKIHVLKLDIEASEAECRHMLEEEGTLD-----LLGLKRE 3139
Query: 1224 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLL-------- 1275
+E + G + + + LE + ++ + + + D E + L
Sbjct: 3140 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3199
Query: 1276 -LHHQQKTKRISAKKRDVQQQIAQAQQ----GEGGLPDRGHE--------ELRKLESTLD 1322
+ +QQ +K V + QQ G+G + G + ++ ++ + +
Sbjct: 3200 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3259
Query: 1323 GLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSELE 1380
L + ++ ++Q L +F+ E ++ +L T ++++ S + + + ++++
Sbjct: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS-AEYKVVKAQIQ 3318
Query: 1381 QTKEFSKRTESIAVQAENLVKEASEIPLGPQ--NKQLLQQQAKSIKEQVKKLEDTLEEDI 1438
+ K + + + L E I + +++ + Q +S++ + +L
Sbjct: 3319 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3378
Query: 1439 KTMEMVKTKWDHFGSNFETLSVWITEKEKELNALE---TSSSAMDMQISQIKVTIQEIES 1495
K +E + F E +S +++ EK+L E T ++ + QI + K ++IE+
Sbjct: 3379 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3438
Query: 1496 KLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGH-LSQQ 1554
+ + + QS + + E + K+ ++ E+++ C + +L LS
Sbjct: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC-CRKAALLDQALSNA 3497
Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL----ESLSSAIT 1610
+ F E+ ++ ++E EDKL+ ++ +H+ L + + +++ AI
Sbjct: 3498 RLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 3557
Query: 1611 AFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALE---NLLAHWQRLEKELS 1665
A ++ + + ++ ++ +Y DI + + LE L +Q +EL+
Sbjct: 3558 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELT 3617
Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
+L +E E A+S + +++ + Q + L+ EV+ + ++ +L
Sbjct: 3618 GWLREVE--EELATSGGQSPTGEQIPQFQQRQ--KELKKEVMEHRLVLDTVNEVSRALLE 3673
Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---- 1781
+ + + + +E+++ + I +R++ + + + QQ+++ + W+
Sbjct: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETK 3733
Query: 1782 -------KLFLSELQTTSEISIMD-HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSL 1833
+ L + QTT+++ + + + RHKD E+ S + E+ G+
Sbjct: 3734 RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI---------FGTC 3784
Query: 1834 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH----LAEFLQSHASLSGILRQLRQ 1889
G E +LQ K E Q +E S + R L + +F +++ LS + + R
Sbjct: 3785 GE-EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 3843
Query: 1890 TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY--HLKIGSSEQRTS 1947
+ S + L ++ + Q +++ +D +L L E
Sbjct: 3844 LIAQLPSPAIDHEQLRQQQ-EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
Query: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
A+ + +++ EA + + F D+ E +L+++E++ R L
Sbjct: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
Query: 2008 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREIN 2061
+++ + EL + LK + +++ A KD+A A E+ +++
Sbjct: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKEIQDKLD 4021
Query: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI-VTRTTIKDQED 2120
++ W+D K E + + +++L ++ +A+ +++ ++ + D
Sbjct: 4022 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI 4081
Query: 2121 LKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLD 2180
+K ET K + + ++L+ G L+ + + V+ ++ + W +
Sbjct: 4082 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE---VRKSIDEMNNAWEN 4138
Query: 2181 VSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCV------PQMAENISNLDNHLRAE 2234
+++ +E +++L ++ T + W +N V P + +++ + + L
Sbjct: 4139 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE- 4197
Query: 2235 ELLKEFESEVKNKALRLEELH-------SKVNDLKELTKNLETPPDLQFIEADLMQKLEH 2287
+KEF+ EV + + +E+L+ K D + E +L+ + +L +K+ H
Sbjct: 4198 --MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4255
Query: 2288 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL-----MNCAQNETCEALKKV 2342
+ E A L F + + ++ +W T EE L ++ L K
Sbjct: 4256 RQHKLEGALLALGQF-------QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4308
Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
++ ++ + Q+ + + + N L + SL + + + E+V Q + +
Sbjct: 4309 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
Query: 2403 LQESLE--KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
LQ +L+ + F +++F ++ S G + +L + + +
Sbjct: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4428
Query: 2461 SKLDAVTQEGQ-TLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGS 2519
+ + +G+ L + S ++ + +++ + + K L++ +
Sbjct: 4429 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATE 4488
Query: 2520 FEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2579
F++ ++ W+ E+ N + + + E HKV F E+ A R+ + +L Q
Sbjct: 4489 FQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV--FANEVNAHRDQIIELDQ 4546
Query: 2580 RG---QLLSEEGHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEA 2632
G + LS++ Q+ L LL S Q+ +++ + E+ RS A + + EA
Sbjct: 4547 TGNQLKFLSQK-----QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 4601
Query: 2633 LQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL 2692
+ + W++ + L D ++ +LS+ ++ G + + I G +AL
Sbjct: 4602 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG-RAL 4660
Query: 2693 RSSN--KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWME 2750
+ E + + L +++ W + SV Q LE + +++ L W+
Sbjct: 4661 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 4720
Query: 2751 SVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFK 2810
V+ ++ L L+D + E T + L REL E + D++
Sbjct: 4721 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 4780
Query: 2811 DTAQ-EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2869
Q +EL T+++ + ++ K ++E+ +K ++ D VH +WL A++ L +
Sbjct: 4781 VKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL 4840
Query: 2870 SGDSSATQKKLSKIKELIDSRE 2891
D+ A Q + KE + E
Sbjct: 4841 PDDTEALQSLIDTHKEFMKKVE 4862
Score = 154 bits (389), Expect = 4e-36
Identities = 445/2581 (17%), Positives = 976/2581 (37%), Gaps = 297/2581 (11%)
Query: 344 LQDKYQSFKHFRVQYEMKRKQIEHLIQP----LHRDGKLSLDQALVK-------QSWDRV 392
L + Q + ++E +R+Q E L + L G +SL + V+ Q W +
Sbjct: 2546 LNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVEL 2605
Query: 393 TSRLFDWHIQLDKSL--PAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHK 450
T +L Q+D+++ + L A+ + ++VQ ++++LE+
Sbjct: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
Query: 451 DLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKY 510
++ + + E + + L+D ++ T L L +E L
Sbjct: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR---LETVALPLQGLEDLAADR 2722
Query: 511 --RLLSLLVLAES------KLKSWIIKYGRRES--------VEQLLQNYVSFIENSKFFE 554
RL + L + +L++W+ +++ +E+L E K
Sbjct: 2723 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 2782
Query: 555 QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISN 614
Q+ +Y+++ E + + EE + + E W LS + +S L++ +
Sbjct: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 2842
Query: 615 WDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEM 674
+Y V L W+ED + AK R +Q +++ + L E
Sbjct: 2843 AQKYQWHVEDLVPWIEDCK--------AKMSELRVTLDPVQLESSLLRSKAMLNEV---- 2890
Query: 675 VSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEP 734
+ ++ LL + ++ + ++ADE D ++ E + A E K
Sbjct: 2891 ---EKRRSLLEILNSAADILI---NSSEADE-DGIRDEKAGINQNMDAVTEELQAKTG-- 2941
Query: 735 LEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKE 794
LE++ QR+ +K I K E K L
Sbjct: 2942 -------------SLEEMTQRLREFQESFKNIEKKV---------EGAKHQLEIFDALGS 2979
Query: 795 QLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQ- 853
Q K L Q++L LE + +F L + + +S L Q
Sbjct: 2980 QACSNKNLEK--LRAQQEVLQALEPQVDYLRNFTQGL------VEDAPDGSDASQLLHQA 3031
Query: 854 --KHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSM 911
QE L ++ ++E + + +F H + Q+AD+ M
Sbjct: 3032 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQF--------HCRVREMFSQLADLDDELDGM 3083
Query: 912 ---VKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968
+ T + +E + K + ++E + LEE+G + L +
Sbjct: 3084 GAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLK------ 3137
Query: 969 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEK 1028
R L A K C +LT+ + Q+ L+ + ++ ++ L+G L E+
Sbjct: 3138 ----RELEALNKQCGKLTE-RGKARQEQLELTLGRVEDFYRKLKG-----LNDATTAAEE 3187
Query: 1029 NRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKL 1088
L V E+ + Q K+ ++ +V P + +++ + + ++
Sbjct: 3188 AEALQWVVGTEVEI-----INQQLADFKMFQKEQV-----DPLQMKLQQVNGLGQGLIQS 3237
Query: 1089 PVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFS-------SWIS 1141
+D D G H ++E+ A ++ +K+ + + ++ +F SW++
Sbjct: 3238 AGKD--CDVQGLEH-DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3294
Query: 1142 TNETQLKGIKGEAIDTANHGEVKRAVEE---IRNGVTKRGETLSWLKSRLKVLTEVSSEN 1198
E + I + +A + VK ++E ++ + R T+ L++ + + +
Sbjct: 3295 DTE---ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA 3351
Query: 1199 EAQKQGDELAKLSSSFKALVTLLSEVEKMLSN-------FGDCVQYKEIVKNSLEELISG 1251
+ +K +L L S + L++ + +K L + F + + + E+ ++
Sbjct: 3352 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLAN 3411
Query: 1252 SKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQ--QIAQAQQGEGGLPDR 1309
S+ V Q KI QQ ++ H+ + I DV Q +I Q+ ++
Sbjct: 3412 SEPVGTQTAKI---------QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQ 3462
Query: 1310 G--HEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFL 1367
G E++ L++ ++ R+ + L F ++ V+ +L + E L
Sbjct: 3463 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEV----EDKL 3518
Query: 1368 SFSSLESLSSEL--EQTKEFSKRTESIAVQAENL---VKEASEIPLGPQNKQ--LLQQQA 1420
S ++ ++ Q + E I + +N+ +K + ++ L+Q++
Sbjct: 3519 SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 3578
Query: 1421 KSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMD 1480
IK + + T + ++T+E + F S +E L+ W+ E E+EL A S
Sbjct: 3579 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL-ATSGGQSPTG 3637
Query: 1481 MQISQIKVTIQEIESKLSS----IVGLEEEAQSFAQFV----TTGESARIKAKLTQIRRY 1532
QI Q + +E++ ++ + + E +++ + V G + Q +
Sbjct: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 3697
Query: 1533 GEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAV--PIKICSSATETYK 1590
+ + + ++ I + Q++E+ V+E + KL PI++ T
Sbjct: 3698 SDTIGQRVDEIDAAI----QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQL 3753
Query: 1591 VLQE--------HMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRR 1642
+Q+ H D L S S I +K V + ++ +L QQYE I
Sbjct: 3754 QVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ----EKTESLIQQYEAISLL 3809
Query: 1643 AKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA-DRVKVEGELQLIQA 1701
ER LE + + W+E E +A ++ A D ++ + + ++
Sbjct: 3810 NSERYARLERAQVLVNQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQ 3867
Query: 1702 LQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761
L+ + KLL++ L + + ++ +M++ ++ + + + + + +R L
Sbjct: 3868 LRESIAEHKPHIDKLLKIGPQLKEL-NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALD 3926
Query: 1762 SVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV---------ALTRHKDHAAE 1812
V++ Q E F I+ L L+ S M + ++ +K E
Sbjct: 3927 EAVSQSTQITE----FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVE 3982
Query: 1813 VESKKGELQSLQGHLAKLGSLGRAEDLHL----LQGKAEDCFQLFEEASQVVERRQLALS 1868
+E + ++L+ +L + D L +Q K + +E+ E R++
Sbjct: 3983 LEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFL 4042
Query: 1869 HLAEFLQSH-ASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
+ E + ++ +L ++ T + + + ES I+ + Q +A E+ D
Sbjct: 4043 DVLELAEKFWYDMAALLTTIKDTQDIVHDL---ESPGIDPSI--IKQQVEAAETIKEETD 4097
Query: 1928 GILSKAQYHLKIGS-------SEQRTSCRATADQLCGE--------VERIQNLLGTKQSE 1972
G+ + ++ +G+ ++ R + D++ ER++ L Q+
Sbjct: 4098 GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAA 4157
Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVF-NQLEDELNSH 2031
L+ F ++K TD +K+ + + ++ V+ Q+E E +H
Sbjct: 4158 VQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNH 4217
Query: 2032 EHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREY 2091
+ EL + KA +D+ P + L+ W++ I Q + G + + ++
Sbjct: 4218 QGEL--MLKKATDETDRDIIREP-----LTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
Query: 2092 QNLKSAVSKVLENASSVIVTRTTIK-DQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGK 2150
Q+ + L + ++ + I D + ++ +KH KN + Q ++ G
Sbjct: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330
Query: 2151 HLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIE 2210
L L+ D S +++ +E+ W V +K EE +L+ ST + +
Sbjct: 4331 EL---LESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ----------STLQQAQ 4377
Query: 2211 GWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLET 2270
G+ + + E ++ +++ L A + + + EL+S++ +E L
Sbjct: 4378 GFHSEIEDFLLE-LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLD 4436
Query: 2271 PPDLQFIEAD--------------LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDI 2316
L + D L QK E K L++ +T+ + + +
Sbjct: 4437 KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4496
Query: 2317 TTWFTKVEESLMNCAQ------NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
W T E+SL N A N +++ K E+ + + I + N L
Sbjct: 4497 INWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 4555
Query: 2371 HSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWFLGAKAA 2428
++ + + + + E V Q + SL ++ + K F E+ ++ +W A++
Sbjct: 4556 QKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESH 4615
Query: 2429 AKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAH-LSKQIVSSIQE 2487
+ + D ++ +L + ++ Q D + G+ L L + +
Sbjct: 4616 LDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDN 4675
Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
+ + +++ + ++ + L++ G F D + L W++++E + +
Sbjct: 4676 FLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD 4735
Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHG--AGQEGRLCSQLLTSH 2605
+ + HKV F EL ++ L + G+ L E +G+L +L T
Sbjct: 4736 LDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL-QELSTRW 4792
Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLS 2665
+ +++ K + AL++ E + + + W+ + L + + L+ +
Sbjct: 4793 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLID 4852
Query: 2666 QIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQ 2725
++ + E V +N A+ GE L + + I+ + ++ + ++++ + Q
Sbjct: 4853 THKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQ 4912
Query: 2726 STLESVISQWNDYVERKNQLEQWME----SVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
LE+ +S+ E +L W++ ++ Q+ + P+ PQ + K ++ +H Q+ +
Sbjct: 4913 QRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI-PQNIDRVKALIAEH-QTFME 4970
Query: 2782 E 2782
E
Sbjct: 4971 E 4971
Score = 128 bits (322), Expect = 2e-28
Identities = 348/1922 (18%), Positives = 741/1922 (38%), Gaps = 191/1922 (9%)
Query: 481 QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA--ESKLKSWIIKYGRRESVEQ 538
Q + ER EL L ++E K + L+ A E++ W++ E + Q
Sbjct: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT-EVEIINQ 3204
Query: 539 LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLS 598
L ++ F + + ++ Q + + +++ G + + + M E A+W L+
Sbjct: 3205 QLADFKMFQKEQ--VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3262
Query: 599 VEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFF---------RN 649
+V + L+E + + ++ + + L +WL D E+++ + ++ +
Sbjct: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322
Query: 650 LPHWIQQHTAMNDA----GNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVK-QYAQAD 704
L + A D G + ++ + + QL L RW EL + + Q +
Sbjct: 3323 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382
Query: 705 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL------EDIEQRVPV 758
++ + K++ + +S F + KKL+ V K+ Q + EDIE
Sbjct: 3383 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3442
Query: 759 MDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKE--CYSPLLYESQQLLIP 816
+ KI + L SP E+G + + L+ + +++++ C L + Q L
Sbjct: 3443 VHQAVKIGQSLSSLT---SPAEQGV-LSEKIDSLQARYSEIQDRCCRKAALLD--QALSN 3496
Query: 817 LEELEKQMTSFYDSLGKINE-IITVLEREAQSSALFKQKHQELLACQE---NCKKTLTLI 872
+ + L ++ + + +V ++ + L +Q H + LA E N KK +
Sbjct: 3497 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ-HADHLALNEEIVNRKKNVDQA 3555
Query: 873 EKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKF 932
K Q++ K T VL +Q ++ I + + + + +E +L KF
Sbjct: 3556 IKNGQALLKQTTGEEVLL------IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF 3609
Query: 933 EESRAELEKVLRIAQEGLEEKGDPE-------ELLRRHTEFFSQLDQR--VLNAFLKACD 983
+ + EL LR +E L G + +R E ++ + VL+ +
Sbjct: 3610 QSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR 3669
Query: 984 ELTDILPEQEQQGLQEAVRKLHKQWK---------------DLQGEAPYHLL---HLKID 1025
L +++P + ++GL + V ++Q+K +Q Y L
Sbjct: 3670 ALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 3729
Query: 1026 VEKNRFLASVEECRTELDRET-KLMPQEGSEKIIKEHRVFFSDKGPHH-----LC-EKRL 1078
E R L ++ R E D+ T +L Q+ I H+ + H C E++
Sbjct: 3730 AETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 3789
Query: 1079 QLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDST-YRKLMEDPDKWKDYTSRFSEFS 1137
+++E L + E + ++S Y +L + + E S
Sbjct: 3790 TVLQEKTESL--------------IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 3835
Query: 1138 SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS- 1196
WI + + AID H ++++ EE+R E + LK+ ++
Sbjct: 3836 PWIEETRALIAQLPSPAID---HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 3892
Query: 1197 --------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1248
E + QK + A++ + L E + + E + +LE L
Sbjct: 3893 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 3952
Query: 1249 ISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
S + + + +KI E + + + + ++ A KR ++ I ++Q +
Sbjct: 3953 SSRLRMPPLIPAEVDKI--RECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4010
Query: 1306 LPDRG-HEELRKLESTLDGLERSRERQERRIQVTLRKWERF--------ETNKET--VVR 1354
L + ++L ++ + ++ E +E + L E+F T K+T +V
Sbjct: 4011 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4070
Query: 1355 YLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQ 1414
L G + + +E+ + E+T + E I + +L+ E K
Sbjct: 4071 DLESPGI--DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4128
Query: 1415 L------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKE 1468
+ + K+ KE+++KLED ++ ++ + ++ +D + L
Sbjct: 4129 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-------- 4180
Query: 1469 LNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKL 1526
+ + T + + Q++++K E+ + + L + + + T E+ R I+ L
Sbjct: 4181 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK-KATDETDRDIIREPL 4239
Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
T+++ E L E + + G L +F+ L ++ ++ E+ L I
Sbjct: 4240 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4299
Query: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDIL 1640
L +H L + + + + + + +++ + S A+ Q +E +L
Sbjct: 4300 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4359
Query: 1641 RRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQ 1700
++ +ER+ L++ L Q E+ FL L R E++ S+ + E +L
Sbjct: 4360 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE-QLDTHM 4418
Query: 1701 ALQNEVVSQASFYSKLLQLKESLFSVASKDDV---KMMKLHLEQLDERWRDLPQIINKRI 1757
L +++ ++ Y++LL + + S+DD + + L+++W + + +R
Sbjct: 4419 ELYSQLKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4476
Query: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV--ALTRHKDHAAEVES 1815
+ L+ + +F L F W+ L L S S++ + V + HK A EV +
Sbjct: 4477 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 4536
Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ-VVER-RQL--ALSHLA 1871
+ ++ L +L L + +D+ L++ +E+ Q +ER R L A
Sbjct: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596
Query: 1872 EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILS 1931
+F ++ L L +++ ++ N+ D I+ L+ + K L D +
Sbjct: 4597 QFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655
Query: 1932 KAQYHLKIGSSEQRTSCRATADQLCGEV-ERIQNLLG---TKQSEADALAVLKKAFQDQK 1987
+ LK + S + D GEV ++ + G +Q + + + F D
Sbjct: 4656 TGR-ALKEKTLLPEDSQK--LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 4712
Query: 1988 EELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ 2047
+ L+ + +E + +++ + + + EL + LK +++ +
Sbjct: 4713 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 4772
Query: 2048 KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
V ++ L WD +L Q + + +++ + + L A
Sbjct: 4773 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 4832
Query: 2108 VIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSL 2166
+ R + D E L+ H+ K+ K+ D+++ + G+ +L+ H +
Sbjct: 4833 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILA---VCHPDCITT 4889
Query: 2167 VKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW----SNNCVPQMAE 2222
+K + ++ +V +++ RL +LS +E+ W + + E
Sbjct: 4890 IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 4949
Query: 2223 NI-SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELT-----KNLETPPDLQF 2276
I N+D R + L+ E ++ +EE+ K D+ +T KN+E P F
Sbjct: 4950 PIPQNID---RVKALIAEHQT-------FMEEMTRKQPDVDRVTKTYKRKNIE-PTHAPF 4998
Query: 2277 IE 2278
IE
Sbjct: 4999 IE 5000
Score = 117 bits (293), Expect = 5e-25
Identities = 399/2277 (17%), Positives = 882/2277 (38%), Gaps = 342/2277 (15%)
Query: 6587 LKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLL------DKH----KEYFQG 6636
L++ YE LQD D + ++ + + K Q L+ DK K Y
Sbjct: 993 LQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISE 1052
Query: 6637 LESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDE 6696
L++ + E ++++ +Q T+ A L+ A + H E
Sbjct: 1053 LKNIRLRLEEYEQRVVK-RIQSLASSRTDRDAWQDNALRIAEQE------------HTQE 1099
Query: 6697 DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL 6756
D Q+L L+ V S + + L+S LN K+ V
Sbjct: 1100 DLQQLRSDLDAVSMKCDSFLHQSPSSSSV-------PTLRSELNLLVEKMDHVYGLSTVY 1152
Query: 6757 LISISCSDLESQLNQLGECWLSNTN-KMSKELHRLETILKHWTRYQSESADLIHWLQSAK 6815
L + D+ + Q E + K+S+E E +L + ++ + L HWL K
Sbjct: 1153 LNKLKTVDVIVRSIQDAELLVKGYEIKLSQE----EVVLADLSALEAHWSTLRHWLSDVK 1208
Query: 6816 DRLEFWT--------------QQSVTVPQ---ELEMVRDHLNAFLEFSKEVDAQSSLKSS 6858
D+ ++ Q S P+ +LE ++ + E V AQ ++ S
Sbjct: 1209 DKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQS 1268
Query: 6859 VLSTGNQLLR---------LKKVDTATLRSE------------LSRIDSQWTDLLTNIPA 6897
L + ++L +K ++ T + E LS SQ T L I
Sbjct: 1269 ELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIER 1328
Query: 6898 VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFK 6957
Q KL Q Q S + I KD + + YKA E QK G +
Sbjct: 1329 NQTKLDQCQK---------------FSQQYSTIVKDYE--LQLMTYKAFVESQQKSPGKR 1371
Query: 6958 IDI--NCKQLTVDFVN-----QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV 7010
+ + +T +F++ +++ +++Q V+ ++ L + + ++++
Sbjct: 1372 RRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKY-------ISDALRRLEEEEKVVEEEK 1424
Query: 7011 TEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDL 7070
E ++ ++ LL S N Q T ET+E ++ A+ + Q L +
Sbjct: 1425 QEHVEKVKELLGWVSTLARNTQGKATSSETKES-----------TDIEKAILEQQVLSEE 1473
Query: 7071 IKAKEKEVEK--------IEQNGLALIQNKKEDVSS-----------IVMSTLRELGQTW 7111
+ K+++V + + ++G L + +K+ +S + + +L Q
Sbjct: 1474 LTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ 1533
Query: 7112 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS--RFRLLTGSLEAVQVQ 7169
+ L H Q K++ Q ++ + + S++ +A +L+ + R L A+Q
Sbjct: 1534 SQLAHQTEQ-----KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN 1588
Query: 7170 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 7229
+L++LQDD++ + S ++E ++ L+E L + E
Sbjct: 1589 QSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK-------LHQAKE 1641
Query: 7230 QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDL 7289
Q ++ + ++ Q K+ + S +QQ+ +++ + A NK D + D
Sbjct: 1642 QYEALQEETRVAQ--KELEEAVTSALQQETEKSKAAKELAENKKKIDALL--------DW 1691
Query: 7290 LKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQA 7349
+ +G+ L EQL A + ++Q L++ + Q
Sbjct: 1692 VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE 1751
Query: 7350 GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 7409
+ + F + ++ +A++ + L ++ +Q+++ ELK Q
Sbjct: 1752 LLSQQQNFILATQSAQAFLDQHGHNLTPEEQQ------MLQQKLGELKEQY--------- 1796
Query: 7410 LDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWM 7469
L ++ E+K++Q L +LQ FL H+ F E+W+
Sbjct: 1797 -------STSLAQSEAELKQVQTLQ--------------DELQKFLQDHKEF----ESWL 1831
Query: 7470 EFLVQTEQKLAVEISGNYQ-----HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ 7524
E ++E++L G LL++Q + F ++ S + L + I GQ++L+
Sbjct: 1832 E---RSEKELENMHKGGSSPETLPSLLKRQGS---FSEDVISHKGDLRFVTISGQKVLDM 1885
Query: 7525 GQV-----DDRDEFNL---KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
+ + NL KL + ++ + + + ++ + Q+ +++ A+ L+
Sbjct: 1886 ENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQ 1945
Query: 7577 KWL----VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL 7632
W+ V L + S P LQ+ L Q +E++ Q L A +
Sbjct: 1946 AWMQACEANVEKLLSDTVASDPGVLQEQ--LATTKQLQEELAEHQVPVEKLQKVARDIME 2003
Query: 7633 LSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT 7691
+ + + +Q I ++S S L E+ L + + ++ + L+ +
Sbjct: 2004 IEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2063
Query: 7692 FK-----KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7746
+ K++S +E A M+ K+ + L ++ ++ ++ D
Sbjct: 2064 VEQNLEGKQVSSLSSGVIQEALATNMKLKQ------DIARQKSSLEATREMVTRFMETAD 2117
Query: 7747 ---ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV 7803
++L ++ + +++E+LC Q + + + L + +F + +L +++ + +S++
Sbjct: 2118 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM-ENKSRM 2176
Query: 7804 SQNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGK 7861
+G+ +++ ++ + E+ QEN L+ + L+ + + ++
Sbjct: 2177 LASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2236
Query: 7862 VNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEE 7921
+ + L + R K + + K + + + WL E + P S +++E
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI--PPTETSMSAKE 2294
Query: 7922 IQRKLNEQQELQRD-------IEKHSTGVASVLNLC-EVLLHDCDACA------------ 7961
+++++ + L D +E+ + S+ NL E+ D
Sbjct: 2295 LEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVG 2354
Query: 7962 ------TDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 8015
T + IQ +++ ++ + + ER+ ++ ++ + + WL
Sbjct: 2355 SVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWL 2414
Query: 8016 KSSERT--AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-ARENRT 8072
+S E + SS K + + +AF ++ + +++ + + L +
Sbjct: 2415 ESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNS 2474
Query: 8073 DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL- 8131
A + K++ E N RW+ + + R+L+ F+ A + WL E +L +
Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 2534
Query: 8132 --------TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA 8183
N+ + + VQ +K+ +A +Q+ H ++ + AQG L +
Sbjct: 2535 VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ----HEQLNEA-AQGILTGPGDVSLSTS 2589
Query: 8184 IIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDR 8243
+++EL + + E+ ++ ++ + + ++ ++L + A L
Sbjct: 2590 QVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL----- 2644
Query: 8244 SADSLLSPQPSS-NLSLSLAQPLRSE-----RSGRDTPASVDSIPLEWDHDY---DLSRD 8294
S S +S QP + L +RS+ ++ D + + Y +L +
Sbjct: 2645 SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR 2704
Query: 8295 LESAMSRALPSED-EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTE 8353
LE+ ALP + E+ D+ L+ A+ + + ++R LDD Q QQ +
Sbjct: 2705 LETV---ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW---LDDK--QSQQAK 2756
Query: 8354 NI-IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 8412
N I +K + + K L + S S + + L S+P + +
Sbjct: 2757 NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLL---SVPPGEEKRTLQN 2813
Query: 8413 QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 8472
Q + + WE L + ++ R+K +QK Q++ + + W+ D + ++ +L+ ++
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELR---VT 2870
Query: 8473 TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD 8532
D +E + + K + V+ R++++ +N + + + ++D + +N D
Sbjct: 2871 LDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMD 2930
Query: 8533 RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHH 8592
V L+ G L++ + + F E + + ++ K+++ D+ L ++ + +
Sbjct: 2931 AVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLEIFDA-LGSQACSNKN 2986
Query: 8593 KQLMQIKHELLES-QLRVASLQDMSCQLLVNA-EGTDCLEAKEKVHVIGNRLKLLLKEVS 8650
+ ++ + E+L++ + +V L++ + L+ +A +G+D + + V + + V+
Sbjct: 2987 LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVN 3046
Query: 8651 RHIKELEKLL-----------DVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQ 8696
+E L ++ S DL DELD G++ GR T + Q
Sbjct: 3047 SGCVMMENKLEGIGQFHCRVREMFSQLADLD-----DELDGMGAI----GRDTDSLQ 3094
Score = 49.7 bits (117), Expect = 1e-04
Identities = 113/608 (18%), Positives = 233/608 (38%), Gaps = 90/608 (14%)
Query: 296 DEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQ---MVESNLQDKYQSFK 352
+E L F NS+Q F W+ E+ L A ++ + + + + K
Sbjct: 4480 EEALNLATEFQNSLQEFIN-----------WLTLAEQSLNIASPPSLILNTVLSQIEEHK 4528
Query: 353 HFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALV---------KQSWDRVTSRLFDWHIQL 403
F + R QI L Q ++ LS Q +V + W++V R + L
Sbjct: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
Query: 404 D------KSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD 457
D K + WL AE L E+ + ++ I+ +L +HK+ +
Sbjct: 4589 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK----IKLQLSKHKEFQKTLG 4644
Query: 458 AHKRAFHEIYRT-RSVNGIPVPPDQ-------LEDMAERFHFVSSTS--------ELHLM 501
+ + RT R++ + P+ L ++ +++ V S E L
Sbjct: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLF 4704
Query: 502 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 561
+F++ L+ L E +L +G + V L+ + F K + T Q
Sbjct: 4705 SGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF---QKELGKRTGTVQ 4761
Query: 562 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 621
+LK++ + + S ++ V + E + +W + S +S LE+ + + + +T
Sbjct: 4762 VLKRSGRELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 4819
Query: 622 VASLQAWLEDAEKML-------NQSE------NAKKDFFRNLPHWIQQHTAMNDA---GN 665
V L WL +AE+ L + +E + K+F + + ++ +N A G
Sbjct: 4820 VHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVE---EKRVDVNSAVAMGE 4876
Query: 666 FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTL 720
++ C +K + ++ R+ E+ KQ+ Q E+ + + + +
Sbjct: 4877 VILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI 4936
Query: 721 SAFATEAHKKLSEPLEVSFMNVKLLIQD----LEDIEQRVPVMDAQYKIITK----TAHL 772
T ++ EP+ + VK LI + +E++ ++ P +D K + H
Sbjct: 4937 QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHA 4996
Query: 773 ITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYES----QQLLIPLEELEKQMTSFY 828
E + G++ + + + E +P + + QQ+ + E ++++
Sbjct: 4997 PFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5056
Query: 829 DSLGKINE 836
D L ++ E
Sbjct: 5057 DRLEELKE 5064
Score = 34.3 bits (77), Expect = 5.6
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 12/227 (5%)
Query: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
+L ++ L EE +L+R E D+ ++ELQ++ + + +V+ + + L
Sbjct: 585 NLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARL--- 641
Query: 8508 EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 8567
+ K S++ ++ G+ + L+E L F + L+ L
Sbjct: 642 ----YEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLN 697
Query: 8568 NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL-LVNAEGT 8626
+ + D+N + +++ +L EL E Q SLQD + L L N
Sbjct: 698 EKEEEELAYDWSDNNSNISAKRNYFSELTM---ELEEKQDVFRSLQDTAELLSLENHPAK 754
Query: 8627 DCLEA-KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSW 8672
+EA V +K L V +H+KE S ++L S+
Sbjct: 755 QTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESF 801
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 340 bits (871), Expect = 5e-92
Identities = 667/3723 (17%), Positives = 1479/3723 (39%), Gaps = 418/3723 (11%)
Query: 2260 DLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTW 2319
D K L K+L + D +L H + E+ K + + Q TQ+E + D+ W
Sbjct: 1887 DAKNLQKSLSSVSDTW------NSRLLHFQNAVEIEKTKVLN---QHTQLEGRLQDLRAW 1937
Query: 2320 FTKVEESLMNCAQNETCEA------LKKVKDIQKELQSQQSN-----------ISSTQEN 2362
L + N + L++ +D+++ + +++ IS ++
Sbjct: 1938 VGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQD 1997
Query: 2363 LNSLCRKYHSAELESLGRAMTGLIKKHEA-VSQLCSKTQASLQESLEKHFS-------ES 2414
L+ + L L R+ ++++ A V L Q QE+L K +
Sbjct: 1998 LSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQ 2057
Query: 2415 MQEFQEWFLGAKAAAKESSDRTG--DSKVLEAKLHDLQNILDSVSDGQSKLDAVT----- 2467
+++ W A+ A RT D L+ DL+++ D + + + V
Sbjct: 2058 LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEG 2117
Query: 2468 --QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHR 2525
+E QT LS + +++++E++ +A E+++A ++ ++ L++ + E +
Sbjct: 2118 FMEENQT---KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKS 2174
Query: 2526 KLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLS----QRG 2581
K + L E+K+ I + V V G+LL +++LS ++G
Sbjct: 2175 KA------------AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222
Query: 2582 QLLSEEGH-GAGQE----GRLCSQLLTSHQNLLRMTKEKL---RSCQVALQEH------E 2627
L + +G+ G Q + C + HQ LL + + +S Q L +H E
Sbjct: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282
Query: 2628 ALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ-IQDIL--------------- 2671
+ Q + + LA +E+ L TL+ L + +QD
Sbjct: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELEN 2342
Query: 2672 -------------LMKGEGEVKLNMAIGKGEQA-----------LRSSNKEGQR------ 2701
L+K +G ++ KG+ + +S KEG+
Sbjct: 2343 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 2402
Query: 2702 VIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ 2761
+++ +L+ E + + S S L ++ Q++ + + L+ WM++ + +E L
Sbjct: 2403 LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLS 2462
Query: 2762 P----QPG-LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY-EKTEDESFKDTAQE 2815
PG L+E+ LQ L+E + L ++ E+ E D +
Sbjct: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522
Query: 2816 ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSA 2875
+ + F + E+ +++ + +++ + ++ L S S
Sbjct: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582
Query: 2876 TQKKLS---KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ 2932
Q+ L+ K+K+ I ++ + + E +TTA+ +Q A+ Q
Sbjct: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA-------VLQGKLAEVSQ 2635
Query: 2933 WEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD 2992
+ + Q E+ + ++ + F +L+Q +E S +L + G D
Sbjct: 2636 RFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS---------GNQPD 2686
Query: 2993 EEIVECWHKGQEILDALQKAEPRTEDLKSQLNEL--CRFSRDLSTYSGKVSGLIKEYNCL 3050
++I + + QE+ ++ + + L+ + EL C F+ DL + +V L K++ L
Sbjct: 2687 QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTEL 2746
Query: 3051 CLQASKGCQNKEQILQQ--RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQ 3108
+ ++ +Q FRK R FQ+WL + + + + E+ ++ ++
Sbjct: 2747 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLK 2805
Query: 3109 EFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAK-------VTAAKEDWKNFHSN- 3160
L + + + + KG L L+ + A Q K V ++ +H+
Sbjct: 2806 SLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCK 2865
Query: 3161 ----------------------LHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHE 3198
LH+++ +L+ + +M++ A + WL E+++
Sbjct: 2866 DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL-- 2923
Query: 3199 SSNRLYDLPAK----RREQQKLQSVLEEIHCYEPQLNRLKEKAQQL---WEGQAASKSFR 3251
S P K + + + ++ L E+ P++ ++KE L + +++++
Sbjct: 2924 KSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWK 2983
Query: 3252 HRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTS 3311
+L+S++ + +T + +L+ + F +L+ W+ + M+ +
Sbjct: 2984 KIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 3043
Query: 3312 DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT--IQQQLQSVKDM 3369
D ++L+++ +++ +L + + Q + + + +L + T +Q++LQS+
Sbjct: 3044 DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQK 3103
Query: 3370 WASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN-------ESERQHAEL 3422
W L SQ++ A+ K T YQ+ ++ S + ++ L+ + E +L
Sbjct: 3104 WVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQL 3163
Query: 3423 RDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT---QLELQDLQERYRAIQER 3479
+ + + + L+ EV +L + + V + E Y+ + L+ + + +++
Sbjct: 3164 EETSEIRSDLEQLDHEVKEAQTLCDELSVL---IGEQYLKDELKKRLETVALPLQGLEDL 3220
Query: 3480 AKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ 3539
A + + + + + Q++Q+ WL +Q + + + ++ L++ +E Q
Sbjct: 3221 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQ 3280
Query: 3540 VHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES----LRQDWQAYQHRLSETRTQFNN 3595
+ ++ E ++ S P E R L++ L+ W+ + ++ +++ +
Sbjct: 3281 KSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKD 3340
Query: 3596 VVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
+ K + + + + W++ + K+S R + E L + K EV R +
Sbjct: 3341 CMQKAQKYQWHVEDLVPWIEDCKAKMS-ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLL 3399
Query: 3656 EEVGARAQEILDESHVNSR-MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
E + + A +++ S + + + + A+ + L+ + SLEE L
Sbjct: 3400 EILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEE-------LQAKTGSLEEMTQRL 3452
Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTV----MMGKKLKTLEVLLKDMEKGHSLLKSAREK 3770
+ + + + K + +++ D + K L+ L + ++ + R
Sbjct: 3453 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNF 3512
Query: 3771 GERAVKYLEEG-EAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
+ V+ +G +A +L + ++ E+ V + +E L +F + + +
Sbjct: 3513 TQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMF 3572
Query: 3830 QWIAEYQEIL-------HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
+A+ + L + + ++ + + L+K L+ + + E + + E+ E
Sbjct: 3573 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EG 3631
Query: 3883 LLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMS 3942
L+L+ LK +++ L L GK LE + ED+ +L+ + +
Sbjct: 3632 TLDLLG---LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND-ATTAA 3687
Query: 3943 GRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKL 4002
A + + +E I QQLA K +E +++ LQMK + G +Q+
Sbjct: 3688 EEAEALQWVVGTEVEIINQQLADFKMFQKE------QVDPLQMKLQQVNGLGQGLIQSAG 3741
Query: 4003 KQNVHAHLQGTKDSYSAICST-----AQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQP 4057
K L+ + +A +T AQR+ Q L+ L QD L+ +WL+ +
Sbjct: 3742 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQ-LQEALLHCGKFQDALEPLLSWLADTE- 3799
Query: 4058 DLEPSPQPPLSRAEAIK-QVKHFRALQ---EQARTYLDLL----------CSMCDLSNAS 4103
+L + +PP + + +K Q++ + LQ + + +D+L + D +
Sbjct: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859
Query: 4104 VKTTAKDIQQTE---------QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ--- 4151
+ + + + TE + +E LV A+ + E I S L +++
Sbjct: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919
Query: 4152 ---QLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEH 4208
++Q RH LE +I +N + V VK QS + + + V L++K +S +
Sbjct: 3920 QTAKIQQQIIRHKALEEDI-ENHATDVHQAVKIGQSLSSLTSPAEQGV--LSEKIDSLQA 3976
Query: 4209 KEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDA 4268
+ + + D+ CR++ L ++ L R + + V +L + + ++ D
Sbjct: 3977 R-YSEIQDR---CCRKAALL----DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 4028
Query: 4269 ESTAVHLEALKKLAL--ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWF 4326
+ +H + LAL + RK ++ Q +++ ++ L++E+ ++ R+
Sbjct: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYA 4088
Query: 4327 QLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMD 4386
+ + ++ + QS ++EL W E + +A + QSP +
Sbjct: 4089 DITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQR 4148
Query: 4387 HLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRK 4446
+ E+ +++L ++ + + ++ + R+ + K +SDA +SD +GQR
Sbjct: 4149 QKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVD 4208
Query: 4447 YLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTY 4506
++ A+ Q+ A + + + +RK+M I L D + Q++ K+ + +
Sbjct: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268
Query: 4507 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
++ + L++ E+ E++K+ + K + L Y+++ S R LE+ V
Sbjct: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
Query: 4567 FKEDFDKACHWLKQ--ADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQR 4624
F E +++ W+++ A I P + +E +L Q + + + E E++ + L +
Sbjct: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHE--QLRQQQEEMRQLRESIAEHKPHIDKLLK 4386
Query: 4625 TGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILAR---KEYASLIE 4681
G L LN + + EK + I + + + EA+ E+ IE
Sbjct: 4387 IGPQ-LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIE 4445
Query: 4682 LTTQSLSELEAQFLRMSKVPTDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
++L L ++ +P ++ + E +S L+++ EA+ ++ G
Sbjct: 4446 PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG- 4504
Query: 4741 RSTGQPWQ------PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQL 4794
RS G DK+ +V + +K + E+R D + EK + L
Sbjct: 4505 RSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLD---VLELAEKFWYDMAALL 4561
Query: 4795 KSVKEEQSKVNEETLPA------EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDP 4848
++K+ Q V++ P +++++ ++ L+ + I DL
Sbjct: 4562 TTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGE 4621
Query: 4849 LAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRR--VKAE 4906
+ R I + L E + + E M ++ +Q + DWL +K
Sbjct: 4622 TEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC 4681
Query: 4907 LSGPVYLDLN-LQDIQEEIR--KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD- 4962
PV DLN ++D E++ K++++Q++++ M L+H+ + KA + D
Sbjct: 4682 TMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDI 4736
Query: 4963 LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQ----L 5018
+ L EL L ++ E + RQ L ++ + WL +ELL +
Sbjct: 4737 IREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPI 4796
Query: 5019 AGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVA-- 5076
+G D + E L H H ++ + AT++ + K G E LE
Sbjct: 4797 SG---DPKVIEVELAKH----------HVLKNDVLAHQATVETVNK-AGNELLESSAGDD 4842
Query: 5077 SLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS- 5135
+ LRS R+ + +LQ+ + Q ++ ++ E L E + +++ S
Sbjct: 4843 ASSLRS-RLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSA 4901
Query: 5136 --------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDA-SKATLSRSMT 5186
A E+L H L S + + E L +K + + +D+ S + +S+
Sbjct: 4902 SKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA 4961
Query: 5187 TVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAE 5246
+ Q+W + + ++++ LE+A++ T F N +++ + + L +S
Sbjct: 4962 LLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNT 5021
Query: 5247 LLTLLEYHDTF----------VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
+L+ +E H F ++EL+Q + L L Q+ +L +
Sbjct: 5022 VLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL-------------IKNL 5068
Query: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQ 5356
+ ++Q R + ++ G+ + K + + W+++ + +L + +EI
Sbjct: 5069 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL-DSELEISND 5127
Query: 5357 LEELQILLTEATNHRQNIE----------KMAEEQKEKYLGLYTILPSELSLQLAEVALD 5406
+++++ L++ ++ + + KEK T+LP + S +L +
Sbjct: 5128 PDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEK-----TLLPED-SQKLDNFLGE 5181
Query: 5407 LKIR-DQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK----------TDNV 5455
++ + D + K E + + S Q + L L K++ + D V
Sbjct: 5182 VRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLV 5241
Query: 5456 VQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQA 5515
+ KV +EL + L + ++ +E + + ++ +L+ + +
Sbjct: 5242 MNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLS 5301
Query: 5516 ENRLSKLNQAASHLEEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLE 5574
++ S+L QA E + + + ++L+W+ +A + L + L+ H+ ++
Sbjct: 5302 VSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMK 5361
Query: 5575 --ESKEID-SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA 5631
E K +D + AM E + + C + + + EE+ K Q L+ A
Sbjct: 5362 KVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL 5421
Query: 5632 KDMKKFEAELKKLQAALEQAQATLTSPEVGRL-----SLKEQLSHRQHLLSEMESLKPKV 5686
++ L++L A ++ A+ TL + + +K ++ Q + EM +P V
Sbjct: 5422 SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDV 5481
Query: 5687 QAV 5689
V
Sbjct: 5482 DRV 5484
Score = 310 bits (794), Expect = 4e-83
Identities = 678/3931 (17%), Positives = 1530/3931 (38%), Gaps = 460/3931 (11%)
Query: 3129 ELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH-QKESALENLKI--QMKDFEVSAEPI 3185
+LL L ++ AK +Q +++ + W + LH Q +E K+ Q E + +
Sbjct: 1879 QLLKAL--EKDAKNLQKSLSSVSDTWNS--RLLHFQNAVEIEKTKVLNQHTQLEGRLQDL 1934
Query: 3186 QDWLSKTEKMVH-ESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL--------KEK 3236
+ W+ +++ + SN D+ + Q+ + + + + + QL+ L E
Sbjct: 1935 RAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEH 1994
Query: 3237 AQQLWEGQ---------AASKSFRHRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHNQF 3285
AQ L Q +SF+ + Q ++Q AL + E+ + + + + N
Sbjct: 1995 AQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC 2054
Query: 3286 SLGIKELQDWMTDAIHMLDSYCHPTS--DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
+++L W+ A L + T+ D S L L+ L Q + +V
Sbjct: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD 2114
Query: 3344 GESVLQNT----SPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVR 3399
E ++ SP + ++++L K+ + +L + +LE A++
Sbjct: 2115 IEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTS-------AL 2167
Query: 3400 QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEH 3459
Q L E++++ L D T +G + ++L+ +E ++ GA + +
Sbjct: 2168 QQETEKSKAAKELAENKKKIDALLDWVTSVGSS---GGQLLTNLPGME--QLSGASLEKG 2222
Query: 3460 YVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYS 3519
+ D + Y + + ++ + E + HQE + F + Q LDQ
Sbjct: 2223 AL------DTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ-- 2274
Query: 3520 VLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDW 3579
H H T + Q LQ E + ++ L E AE + +++L+ +
Sbjct: 2275 ------HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSE---------AELKQVQTLQDEL 2319
Query: 3580 QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLH 3639
Q + Q ++ + WL+ +E+++ + S+ T L
Sbjct: 2320 QKFL---------------------QDHKEFESWLERSEKELENMHKGGSSPETLPSLLK 2358
Query: 3640 QMKKWHEEVTAYRDEVEEVGARAQEILD----------ESHVNSRMGCQATQLTSRYQAL 3689
+ + E+V +++ ++ V Q++LD S + + + + T RY AL
Sbjct: 2359 RQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL 2418
Query: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749
+ L + + ++S S W + N + + + D ++ ++L T
Sbjct: 2419 HSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 2478
Query: 3750 LEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEA---ERLRKEIHDHMEQLKELTSTVRK 3806
+ L +++ + H + +K R + +E A +++ + + L+ ++ +
Sbjct: 2479 TKQLQEELAE-HQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE 2537
Query: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTV 3866
L+K + ++ + ++L Q I E ++ L + + + L+ L+Q +
Sbjct: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597
Query: 3867 LSHEPSVKSVREKGEALLELVQDVT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKD 3923
+ S+++ RE +E T L+ K+ ++ ++ LC +E SL+ +
Sbjct: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQ 2657
Query: 3924 HEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNL 3983
E + ++++++ S R++A + QQ+ ME+ D L +L
Sbjct: 2658 AEMFEHLSGKLQQFMENKS-RMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHL 2716
Query: 3984 QMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQD 4043
T + C L Q+ +Q + ++ + T + + ++ +
Sbjct: 2717 V----TELSSCGFALDLCQHQD---RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRK 2769
Query: 4044 TLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE----QARTYLDLLCSMCDL 4099
++ Q WL + + P+ + +S E KQ++H ++L + + ++ C L
Sbjct: 2770 LVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSL 2828
Query: 4100 SNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRR 4159
N ++ TA D Q +I + + G+ K L +E+ + D
Sbjct: 2829 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL-TEIQCDMSD----------- 2876
Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
+N+ + V L +Q S+ I+ ++ ++ HKE N + QWL
Sbjct: 2877 -----VNLKYEKLGGV------LHERQESLQAILNRMEEV--------HKEANSVL-QWL 2916
Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALK 4279
+ +E++ ++ D E ++ AES L L+
Sbjct: 2917 E-----------SKEEVLKSMDAMSSPTKTET------------VKAQAESNKAFLAELE 2953
Query: 4280 KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVS 4339
+ + +Q+ K A+ L ++ + N + E K+ L RW + ++ + +
Sbjct: 2954 QNSPKIQKVKEALAGL------LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQL 3007
Query: 4340 VTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4399
+ L Q+ +L W E++ + S P+M + E EA++
Sbjct: 3008 EESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQ 3067
Query: 4400 LLKSLIKDADRVMA---DLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKT 4456
+ L + A ++ D+ L+ QV ++ S Q V L+D + R +++A+ + T
Sbjct: 3068 QHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE-LTDKLNSRSSQIDQAIVKST 3126
Query: 4457 QFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQ 4516
Q+ + + +++ +++ + I P+ V +Q++ ++ L+ +EV
Sbjct: 3127 QYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTL 3186
Query: 4517 GRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKAC 4575
EL + EQ K E+ +L+ + + + R+ L+ L S + F++ FD+
Sbjct: 3187 CDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELR 3246
Query: 4576 HWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNE 4635
WL + + L +QL + + + ++ + G+++L S+
Sbjct: 3247 TWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 3306
Query: 4636 VDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQF 4694
+ L +L L + + D+ ++++ + ++Y +E + + +A+
Sbjct: 3307 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM 3366
Query: 4695 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLH 4754
+ + +E +L +A+L+EV ++ LN + ++ + +
Sbjct: 3367 SELRVTLDPVQLESSLLRS---KAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDE 3423
Query: 4755 LVTLYHRLKRQTEQ---RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE---------QS 4802
+ + TE+ + LE+ T +E ++ + +E++++ K + Q+
Sbjct: 3424 KAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQA 3483
Query: 4803 KVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQ 4862
N+ EKL+ + +L+ L+ T L + AP D + HQ + Q
Sbjct: 3484 CSNKNL----EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAP--DGSDASQLLHQAEVAQ 3537
Query: 4863 GELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQE 4922
E + + E+++ F + L + EL G + + +Q
Sbjct: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597
Query: 4923 EIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALR 4982
+I +++ ++ + A + + + L L+ L L++ G + E +
Sbjct: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK 3657
Query: 4983 TRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN-GLDVESAEENLKSHMEFFST 5041
RQ L + + +Y+ + ND A+E L G +VE + L F
Sbjct: 3658 ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKE 3717
Query: 5042 E-DQFHSNLEELHSLVATLDPLIKPTGKE----DLEQKVASLELRSQRMSRDSGAQVDLL 5096
+ D L++++ L LI+ GK+ LE + + R +++ ++ L
Sbjct: 3718 QVDPLQMKLQQVNGLG---QGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQL 3774
Query: 5097 QRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFH 5156
Q +Q A E ++ + DTE+ ++ ++ + ++ E K L +++
Sbjct: 3775 QEALLHCGKFQDALEPLLSWLADTEELIAN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRK 3833
Query: 5157 EKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGF 5216
+ L+ + ++ ++ A + ++ + ++ RWT L + A ++K LED + F
Sbjct: 3834 ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3893
Query: 5217 NNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ--Q 5274
+ + ++ + + KL S A++ + H ++E + + + Q
Sbjct: 3894 HETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3953
Query: 5275 TLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINS 5334
+LS L +P E+ L ++I ++Q R +Q++ L+ Q L + +
Sbjct: 3954 SLSSLT-----SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 4008
Query: 5335 VKCWVQETKEYLGNPTIE------IDAQLEELQILLTEATNHRQNIE---KMAEEQKEKY 5385
V W+ E ++ L + ++ + Q + L E N ++N++ K + ++
Sbjct: 4009 VLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQT 4068
Query: 5386 LGLYTILPSE----LSLQLAEVAL-DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKD 5440
G +L E + + A++ + K ++ + + ++T +EL+ ++++ ++
Sbjct: 4069 TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEE 4128
Query: 5441 LTTILTKLKAKTDNVVQAKTDQKVLGEE-------LDGCNSKLMELDAAVQKFLEQNGQL 5493
L T + + + Q + QK L +E LD N E+ A+ + + +
Sbjct: 4129 LATSGGQ-SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN----EVSRALLELVPWRARE 4183
Query: 5494 GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIE--KAKVLAH 5551
G L K + E ++ R+ +++ A ++Y + + L W+ K K++A
Sbjct: 4184 G--LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241
Query: 5552 GTIAWNSASQLREQYILHQTLLEESKEID--SELEAMTEKLQYLTSVY--CTEK----MS 5603
G I +L + Q ++++ ID ++M E + + ++ C E+ +
Sbjct: 4242 GPI------RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ 4295
Query: 5604 QQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQAT---LTSPEV 5660
++ L ++ E + + R L+ A + +F ++L +E+ +A L SP +
Sbjct: 4296 EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAI 4355
Query: 5661 GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEAS 5720
L++Q + L + KP + + L+ + + + + +
Sbjct: 4356 DHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM-VEEKYQKAENMYA 4414
Query: 5721 RLQHTAIQQCNIMQAAVVQYEQ---YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQ 5777
+++ Q+ + AV Q Q + +++ + + +E + P+ + + +++
Sbjct: 4415 QIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIREC 4474
Query: 5778 ISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGT----EDLDG 5833
IS ++ +++ Q +L + + L +++ A L E++ + ED+
Sbjct: 4475 ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKA 4534
Query: 5834 ELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVN 5893
V+ + + + + +T + ++ SP ++
Sbjct: 4535 RAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP--------------GID 4580
Query: 5894 QDIAYYQALSAERLQTDAAKIHPSTS-----ASQEFYEPGL--EPSATAKLGDLQRSWET 5946
I Q +AE ++ + +H + + G +P + ++ +WE
Sbjct: 4581 PSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4640
Query: 5947 LKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG---RSPESQMAEH 6003
L E+ L +A++ +YQD+LQ++ ++ +KL P G + + Q+ E
Sbjct: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEM 4700
Query: 6004 QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASG 6063
+ E+ Q E+ +L E ++ ++ D ++ ++ LT L + K +
Sbjct: 4701 KEFKVEVYQQQIEMEKLNHQ-GELMLKKA--TDETDRDIIREPLTELKHLWENLGEKIAH 4757
Query: 6064 KRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQL 6123
++ LE L AL +++ +EL SWL T+ LD +P +E +L
Sbjct: 4758 RQHKLEGAL----------LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVEL 4807
Query: 6124 MD---CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ 6180
+N ++ + V +++ N LLE A D+A L +L + +
Sbjct: 4808 AKHHVLKNDVLAHQATVETVNKAG----NELLESSA--GDDASSLRSRLEAMNQCWESVL 4861
Query: 6181 RALHDKQLNMQGTAQEKE--ESDVDLTATQSPGVQEWLAQARTT--WTQQRQSSLQQQKE 6236
+ +++ +Q T Q+ + S+++ + ++ L+ ++ T + + L E
Sbjct: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4921
Query: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE-----LGMEGEKSSA 6291
L +L ++ + +G +L+ + + + +L Q+ ME KS
Sbjct: 4922 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKL 4981
Query: 6292 EDQMRM--KWESLHQEF--------------STKQKLLQNVLEQEQEQVLYSRP-----N 6330
E+ + + ++++ QEF S +L VL Q +E +++ +
Sbjct: 4982 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 5041
Query: 6331 RLL----SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSGGAKRQSIHLEQKL 6383
+++ +G L K QD + +LL + +E+V S + G + + ++
Sbjct: 5042 QIIELDQTGNQL-KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQF 5100
Query: 6384 YDGVSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKEMSEEMD------- 6434
++ WL+D E L + P++ + L + K + D
Sbjct: 5101 HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGR 5160
Query: 6435 --KNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQND 6492
K K L PE+ D LG + V + + + +L++ L F
Sbjct: 5161 ALKEKTL----LPEDSQKLD-------NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 5209
Query: 6493 LKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFD------AGIIELKRR 6546
+L D Y + +LA +QPV ++ + D K F G +++ +R
Sbjct: 5210 FMDALQALVDWLYKVEPQLAE--DQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 5267
Query: 6547 GDKLQVEQPS------MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6600
+ +E +L +L +D + + S++S L Q L + + L +
Sbjct: 5268 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI------------------ 6642
L ++ + + + E +Q L+D HKE+ + +E +
Sbjct: 5328 WLSEAEQTLR-FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHP 5386
Query: 6643 -----------LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETW 6691
+ F +++++A Q + + T L S ++ A L +I W
Sbjct: 5387 DCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL----SELVANAELLEELLAWI--QW 5440
Query: 6692 SH---LDEDQQELSRQLEVVESSIPSVGLVEENEDRL---IDRITLYQHLKSSLNEYQPK 6745
+ + DQ+ + + ++ V++ I E R +DR+T K+ + P
Sbjct: 5441 AETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPF 5500
Query: 6746 LYQVLDDGKRLLIS--------ISCSDLES-QLNQLGECW-------LSNTNKMSKELHR 6789
+ + G++ L +S S+ ++ ++NQL W L K++ L R
Sbjct: 5501 IEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDR 5560
Query: 6790 LETILKHWTRYQSE--SADLIHWLQSAKDRL 6818
LE LK + + + + W+ K R+
Sbjct: 5561 LEE-LKEFANFDFDVWRKKYMRWMNHKKSRV 5590
Score = 297 bits (760), Expect = 4e-79
Identities = 724/3946 (18%), Positives = 1524/3946 (38%), Gaps = 472/3946 (11%)
Query: 4897 LDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE-------VQSSLRIMNALSHKEK 4949
L LR ++ L+LNL ++Q+ + + ++ + E V L +N + +
Sbjct: 1814 LSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQP 1873
Query: 4950 EK----FTKAKELISADLEHSLAELSELDGD----IQEALRTRQATLTEIYSQCQRYYQV 5001
++ KA E + +L+ SL+ +S+ Q A+ + + ++Q + Q
Sbjct: 1874 QEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD 1933
Query: 5002 FQAANDWLEDAQELLQLAGNG--LDVESAEENLKSHMEFFSTEDQFHSNLE----ELHSL 5055
+A W+ + +L G+ +DV+S L+ + + + + L+ ++
Sbjct: 1934 LRA---WVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFF 1990
Query: 5056 VATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIE 5115
++ + P + + + L+ Q + + AQVD LQ H Q +E +++
Sbjct: 1991 ISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQG-----HLQQMEQEALVK 2045
Query: 5116 LMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5175
+ + + S +AE L+ H+ + + + AL++ S L+ +D
Sbjct: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTT-----QQDLSALQKNQSDLKDLQDD 2100
Query: 5176 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP 5235
+ R T V +D E +E+ N+ K + + L++KL
Sbjct: 2101 ------------IQNRATSFATVVKDIEGFMEE---------NQTKLSPRELTALREKLH 2139
Query: 5236 GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ 5295
+ + + E +T V + E +++ L+Q+T E+ +
Sbjct: 2140 QAKEQYEALQE--------ETRVAQKELEEAVTSALQQET-------------EKSKAAK 2178
Query: 5296 EITAMQ---DRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLG--NPT 5350
E+ + D L+ V ++G + L E + + + K + T Y+G
Sbjct: 2179 ELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQL-SGASLEKGALDTTDGYMGVNQAP 2237
Query: 5351 IEIDAQLEEL----QILLTEATN--------------HRQNIEKMAEEQKEKYLGLYTIL 5392
++D Q E + Q LL++ N H N+ ++ ++ LG L
Sbjct: 2238 EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGE---L 2294
Query: 5393 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5452
+ S LA+ +LK +QD++++ Q +E +++ K+L + K +
Sbjct: 2295 KEQYSTSLAQSEAELKQVQTLQDELQKFLQDH---KEFESWLERSEKELEN-MHKGGSSP 2350
Query: 5453 DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI 5512
+ + Q E++ L + + QK L+ + K+ ++ L + +
Sbjct: 2351 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE--GKEPSEIGNLVKDKL 2408
Query: 5513 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL 5572
+ A R + L+ + L + L ++L + + A AW A + + +L T+
Sbjct: 2409 KDATERYTALHSKCTRLGSH---LNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTV 2465
Query: 5573 LEESKEIDSELEAMTEKLQ-----YLTSVYCTEKMSQQVAELG-------RETEELRQMI 5620
+ + +L A T++LQ + V +K+++ + E+ R +E I
Sbjct: 2466 ASDPGVLQEQL-ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSI 2524
Query: 5621 KIRLQNL-----------QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS---LK 5666
Q+L Q A + + L+ L ++ + + L +V LS ++
Sbjct: 2525 LSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQ 2584
Query: 5667 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5726
E L+ L ++ K ++A + + D + L +L E + R +
Sbjct: 2585 EALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQG---KLAEVSQRFEQLC 2641
Query: 5727 IQQC---NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEE 5783
+QQ + ++ + Q E +E LQQ +E R + +I QI +E
Sbjct: 2642 LQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI---QE 2698
Query: 5784 LAQKIKGYQEQIASLN------SKC-----------KMLTMKAKHATMLLTVTEVEGLAE 5826
L +++ QE + +L S C ++ ++ + TV E E A
Sbjct: 2699 LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDAS 2758
Query: 5827 GTEDLDGELLPTPSAHPSVVMMTAGRC---HTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
++ E + T G T +S E E S + + +
Sbjct: 2759 SCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLV 2818
Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS----QEFYEPGLEPSATAKLGD 5939
N + +++ ++A Q I PS +S ++ + D
Sbjct: 2819 EEINCKGTSLENLI--MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSD 2876
Query: 5940 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSE-----SPEPGR 5994
+ +E L V+ E+Q +L L R ++ S+ +E+ E L SP
Sbjct: 2877 VNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTE 2936
Query: 5995 SPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
+ ++Q ++A + E+ +I +++ +LA LV+ + +Q L ER
Sbjct: 2937 TVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERA 2996
Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
+ + + QLEE A ++ +L WL+ + +
Sbjct: 2997 TEVTVARQR-----------QLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSI 3043
Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
+P + AQ Q ML E E + +L+ + +L G Q+ +L+ +
Sbjct: 3044 DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQ 3102
Query: 6175 SLLELQRALHDK-----QLNMQGTAQEKEESDVD---LTATQSPGVQEWLAQARTTWTQQ 6226
+EL L+ + Q ++ T ++ D+ Q VQ ++ QQ
Sbjct: 3103 KWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQ 3162
Query: 6227 RQSSLQQQKELEQ---ELAEQKSLLRSVASR-GEEIL-------IQHSAAETSGD---AG 6272
+ + + + +LEQ E+ E ++L ++ GE+ L ++ A G A
Sbjct: 3163 LEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAA 3222
Query: 6273 EKPDVLSQELGMEGEKSSAEDQMRMKWESLHQE------FSTKQKLLQNVLEQEQE---- 6322
++ + L L + D++R + + S K + LQ+ L++ +E
Sbjct: 3223 DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKS 3282
Query: 6323 --------QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
+V+ + LL VP P ++K + + L L +EE+S ++ A R
Sbjct: 3283 LNQHSGSYEVIVAEGESLLLSVP------PGEEKRTLQNQLVELKNHWEELSKKT--ADR 3334
Query: 6375 QS-----IHLEQKLYDGVSATSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKE 6428
QS + QK V W++D + ++ + L P + E+ L + + ++++
Sbjct: 3335 QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK 3394
Query: 6429 MSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN 6488
++ + + + D I D + + + + + ++E Q++
Sbjct: 3395 RRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLRE 3454
Query: 6489 FQNDLKVLFTSLADNKYII-------LQKLANVFEQPVAEQIEAIQQAE---DGLKEFDA 6538
FQ K + + K+ + Q +N + + Q E +Q E D L+ F
Sbjct: 3455 FQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQ 3514
Query: 6539 GIIELKRRGDK----LQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERA 6594
G++E G L + + QE +++ + +++ ++ G+ Q +
Sbjct: 3515 GLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQ 3574
Query: 6595 LQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES------HMILTETLF 6648
L DL D L+ G + D + S E+++ L+K +E+ HM+ E
Sbjct: 3575 LADLDDELD-GMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTL 3633
Query: 6649 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYIL---ETWSHLDEDQQELSRQL 6705
+ +++E + L Q + +R R +LE L E + + + +
Sbjct: 3634 DLL---GLKRELE---ALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAA 3687
Query: 6706 EVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISIS---- 6761
E E+ VG E ++ + ++Q K ++ Q KL QV G+ L+ S
Sbjct: 3688 EEAEALQWVVGTEVEIINQQLADFKMFQ--KEQVDPLQMKLQQVNGLGQGLIQSAGKDCD 3745
Query: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
LE + ++ W + K+++ + +L+ L H ++Q L+ WL ++ +
Sbjct: 3746 VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3805
Query: 6822 TQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-DTATLRSE 6880
S E ++V+ + + +D + + + + G ++ + ++ D + +
Sbjct: 3806 KPPSA----EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 3861
Query: 6881 LSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNS 6940
L ++S+WT+LL+ A Q++L + + + ++S+ E + E
Sbjct: 3862 LESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP----- 3916
Query: 6941 IGYKA--IHEYLQKYKGFKIDINCKQLTVDF---VNQSVLQISSQDVESKRSDKTDFAEQ 6995
+G + I + + ++K + DI V + QS+ ++S + S+K D
Sbjct: 3917 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID---- 3972
Query: 6996 LGAMNKSWQILQGLVTEKIQLLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHRIGDQ 7054
++ + +Q K LL+ L + + E+ V+ L E ++K + Q
Sbjct: 3973 --SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ 4030
Query: 7055 ASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANL 7114
+ D L + I ++K V++ +NG AL++ + ++ L + +A++
Sbjct: 4031 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADI 4090
Query: 7115 DHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQ 7174
+ L+ + + ++++ +L E L+ +G Q+ Q
Sbjct: 4091 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELAT----SGGQSPTGEQIPQFQ 4146
Query: 7175 NLQDDLEKQERS----LQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQ 7230
Q +L+K+ L ++ LL+ E L + + N ++ + + I ++
Sbjct: 4147 QRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQR 4206
Query: 7231 LQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLL 7290
+ A +Q Q+Y+ Q A T L A + D+ +Q
Sbjct: 4207 VDEIDAAIQRSQQYE----QAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 4262
Query: 7291 KGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAG 7350
+ KDS+ L ++ + +Q SL Q A+ ++ L+
Sbjct: 4263 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 4322
Query: 7351 VLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDL 7410
+ F ++ E L WI E ++ Q PS + D ++++ EE++ + P +
Sbjct: 4323 QVLVNQFWETYEELSPWIEETRALI-AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHI 4381
Query: 7411 DRLNELGYRLP-LNDKE----IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT---FL 7462
D+L ++G +L LN +E ++ Q ++ I + +R L + Q F
Sbjct: 4382 DKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFH 4441
Query: 7463 EKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQR 7520
+K E +E L +L + I + E ++ E+ Q ++ G+
Sbjct: 4442 DKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 4501
Query: 7521 LLEQGQVDDRD----EFNLKLTLLSNQWQGVIRRAQQRR----GIIDSQIRQWQRYREMA 7572
L+ + Q D+D E KL + W+ + RA++R +++ + W +
Sbjct: 4502 LIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALL 4561
Query: 7573 EKLRKWLVEVSYLPMSGLGSVPIPLQ--QARTLFDEVQ--FKEKVFLRQQGSYILTVEAG 7628
++ V L G+ I Q A T+ +E +E F+R G+
Sbjct: 4562 TTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA-------- 4613
Query: 7629 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK---DWEKCEKGIADS 7685
L+ + + ++ + E+ W++ + +E+ +KL ++ ++ + + D
Sbjct: 4614 -DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDW 4672
Query: 7686 LEK--------------LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQL 7731
L+ L T K +L++ + + E++ +Q+ ++L + +L
Sbjct: 4673 LDNTVIKLCTMPPVGTDLNTVKDQLNE-MKEFKVEVYQQQIEMEKLNHQ--------GEL 4723
Query: 7732 SLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKE 7791
L K T D I+ E + L+ WE L +++ R+ ++ L F +E
Sbjct: 4724 MLKKAT-----DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEE 4778
Query: 7792 LCEWLTQMESKVSQ----NGDILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKA 7846
L WLT E + +GD + E +E K + +A + ++ + + G L ++
Sbjct: 4779 LMSWLTHTEELLDAQRPISGDPKVIE-VELAKHHVLKNDVLAHQATVETVNKAGNELLES 4837
Query: 7847 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 7906
S AS + +L +N W+ +L R ++L+ TL Q + L +ES
Sbjct: 4838 SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMES 4897
Query: 7907 ELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 7964
+L+ KP E + +L+ EL ++ +L+ ++L D + +
Sbjct: 4898 QLSASKPT---GGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS 4954
Query: 7965 ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 8024
+ + Q+ L+++W + + ER+ K+EE L +F + F +WL +E++
Sbjct: 4955 KTE---QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
Query: 8025 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHE 8084
S +I ++++ + F +V+ Q+ +++ +L ++ +K ++
Sbjct: 5012 ASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVS 5071
Query: 8085 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-V 8142
RW+ + +R R L + ++F A ++ WL + + L + +E ++ D +
Sbjct: 5072 VQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKI 5131
Query: 8143 QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKS-EPLDAAIIEEELDELRRYCQEVFG 8201
+ ++ + K FQ+ + + I G L EK+ P D+ ++ L E+R V G
Sbjct: 5132 KLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCG 5191
Query: 8202 R-VERYHKKLIRLPLPDDEHDLSDRELE---------LEDSAALSDLHWHDRSADSLLSP 8251
+ VER HK L D ++ ED DL D+
Sbjct: 5192 KSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF 5251
Query: 8252 QPSSNLSLSLAQPLRSERSGRD-----------TPASVDSIPLEWDHDYDLSRDLESAMS 8300
Q Q L+ RSGR+ + + WD LS +S +
Sbjct: 5252 QKELGKRTGTVQVLK--RSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 5309
Query: 8301 RALPSEDE---------EGQDDKDFYLRGAVGLSGDHSALESQI---RQLGKALDDSRFQ 8348
+AL + E + + LR L D AL+S I ++ K +++ R
Sbjct: 5310 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVD 5369
Query: 8349 IQQT----ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL---KEEEESL 8401
+ E I+ P+ T+ K ++ ++ R E L K+ ++ L
Sbjct: 5370 VNSAVAMGEVIL---AVCHPDCITTIKHWITIIR---------ARFEEVLTWAKQHQQRL 5417
Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ-FNSDLNSIWAWLGDTE 8460
ET + ++ ELL+ + +Q+ Q+ +++ + A + + +
Sbjct: 5418 ---------ETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQ 5468
Query: 8461 EELEQLQRLELSTDIQTIELQIKKLKEL------QKAVDHRKAIILSINLCSPEFTQADS 8514
+E++ R + D T + K ++ + RK++ P +Q+++
Sbjct: 5469 TFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEA 5528
Query: 8515 KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSH 8560
K R++Q++ RW +V L E + L DAL + + E ++
Sbjct: 5529 K-----NPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFAN 5569
Score = 280 bits (715), Expect = 6e-74
Identities = 668/3713 (17%), Positives = 1409/3713 (37%), Gaps = 408/3713 (10%)
Query: 736 EVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE----EGKEMFATMSK 791
E+ ++ L +Q ED++Q + AQ + E Q+ + ++M +++
Sbjct: 1953 EIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNE 2012
Query: 792 LKEQLTKVKECYSPLLYESQQLLIPLEE------LEKQMTSFYDSLGKINEIITVLEREA 845
L+ + E + + Q L +E+ L+KQ + + L + + ER A
Sbjct: 2013 LQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAER-A 2071
Query: 846 QSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHF-----------DQ 894
+ + Q+L A Q+N L + F T+ ++ F +
Sbjct: 2072 LAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL 2131
Query: 895 TRLQRQIADIHVAFQSMVKKTGDWKKHVE--TNSRLMKKFEESRAELEKVLRIAQEGLEE 952
T L+ ++ ++++ ++T +K +E S L ++ E+S+A A+E E
Sbjct: 2132 TALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKA--------AKELAEN 2183
Query: 953 KGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQ-------QGLQEAVRKLH 1005
K + LL T S Q + N L ++L+ E+ G+ +A KL
Sbjct: 2184 KKKIDALLDWVTSVGSSGGQLLTN--LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 2241
Query: 1006 KQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFF 1065
KQ C R +L+ Q+ + + + F
Sbjct: 2242 KQ------------------------------CEMMKARHQELLSQQQNFILATQSAQAF 2271
Query: 1066 SDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK 1125
D+ H+L + Q++++ +L ++ + LK+++ D +K ++D
Sbjct: 2272 LDQHGHNLTPEEQQMLQQKLGEL--KEQYSTSLAQSEAELKQVQTLQDEL-QKFLQD--- 2325
Query: 1126 WKDYTSRFSEFSSWISTNETQLKGI-KGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWL 1184
EF SW+ +E +L+ + KG + +KR + ++ +G+
Sbjct: 2326 -------HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVT 2378
Query: 1185 KSRLKVLTEVSSENEAQKQGDELA-----KLSSSFKALVTLLSEVEKMLSNFGDCVQYKE 1239
S KVL +S E K+ E+ KL + + L S+ ++ S+ +
Sbjct: 2379 ISGQKVLDMENSFKEG-KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYH 2437
Query: 1240 IVKNSLEELISGSKEVQEQAEKIL-DT---------ENLFEAQQL---LLHHQQKTKRIS 1286
+NS + L + + + EK+L DT E L +QL L HQ +++
Sbjct: 2438 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 2497
Query: 1287 AKKRDVQQQIAQAQQGEGGLPDRGH--EELRKLESTLDGLERSRERQERRIQVTLRKWER 1344
RD+ + +GE PD H E + S L S + +Q + + +
Sbjct: 2498 KVARDIME-----IEGEPA-PDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQS 2551
Query: 1345 FETNKETVVRYLFQTGSSHE--RFLSFSS---LESLSSELEQTKEFSKRTESIAVQAENL 1399
+ + E++++ + + + E + S SS E+L++ ++ ++ +++ S+ E +
Sbjct: 2552 VQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV 2611
Query: 1400 VK-----EASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSN 1454
+ +++ + + Q+ + + Q ++ E +L++ + EM
Sbjct: 2612 TRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEM----------- 2660
Query: 1455 FETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFV 1514
FE LS + + + + + S + D I+ IQE+ ++ +E + V
Sbjct: 2661 FEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMED---QQENLDTLEHLV 2717
Query: 1515 TTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDK 1574
T S L Q + + LR+ L+ T+ +E L + ++ V F+
Sbjct: 2718 TELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKW 2777
Query: 1575 L------AVPIKICSSATETYKVLQEHMDLCQ-----------------ALESLSSAITA 1611
L P + SA E K ++ L +LE+L ITA
Sbjct: 2778 LKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITA 2837
Query: 1612 -------------FSASARKVVNRDSCVQ------EAAALQQQYEDILRRAKERQTALEN 1652
+S V +C + + + +YE + ERQ +L+
Sbjct: 2838 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2897
Query: 1653 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
+L + + KE +S L WLE E S MD + K E ++ + +
Sbjct: 2898 ILNRMEEVHKEANSVLQWLESKEEVLKS--MDAMSSPTKTETVKAQAESNKAFLAELEQN 2955
Query: 1713 YSKLLQLKES----LFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQ 1768
K+ ++KE+ L + + + + K E+L+ RW ++ R L+ +
Sbjct: 2956 SPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLA 3015
Query: 1769 QFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLA 1828
F W+ + +SI + + + + E + Q Q + A
Sbjct: 3016 CFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEA 3075
Query: 1829 KLGSLGRAEDLHLLQGKAEDCFQ-LFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
G L D+ L + + Q + ++ ++ ++ S + + + +L+ L
Sbjct: 3076 AQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDL 3135
Query: 1888 RQTVEATNSMNKNESDLIEKD--LNDALQNAKALESAAVSLDGILSKAQ-----YHLKIG 1940
+ V A +S + + + L+ + S LD + +AQ + IG
Sbjct: 3136 SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIG 3195
Query: 1941 SSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEER 2000
+ + + + ++ +++L + + A + FQ +EL ++D + +
Sbjct: 3196 EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 3255
Query: 2001 TDKERLKEPTRQALQQRLRVFNQLEDELNSH--EHELCWLKDKAKQIAQKDVAFAPEVDR 2058
K + LQ +L+ + + LN H +E+ + ++ ++ +
Sbjct: 3256 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 3315
Query: 2059 EINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQ-NLKSAVSKVLENASSVIVTRTTIKD 2117
++ L+ W++ + + Q + + ++YQ +++ V + + + + R T+ D
Sbjct: 3316 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-D 3374
Query: 2118 QEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHS---SDFSLVKTDMEST 2174
L+ + + + N++ ++ L+ S L++ + + + + +M++
Sbjct: 3375 PVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV 3434
Query: 2175 VDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE 2234
++ + LEE RLR + + ++EG A++ + + L ++
Sbjct: 3435 TEELQAKTGSLEEMTQRLR---EFQESFKNIEKKVEG---------AKHQLEIFDALGSQ 3482
Query: 2235 ELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEITE 2293
+ +++ + L+ L +V+ L+ T+ L E PD +D Q L A+ +
Sbjct: 3483 ACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVAQQ 3538
Query: 2294 VAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQ 2353
+ + +E + I + +V E A + + L + I ++ S Q
Sbjct: 3539 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD--DELDGMGAIGRDTDSLQ 3596
Query: 2354 SNISSTQENLNSL-------------CRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQ 2400
S I + LN + CR H E E + GL ++ EA+++ C K
Sbjct: 3597 SQIEDVRLFLNKIHVLKLDIEASEAECR--HMLEEEGT-LDLLGLKRELEALNKQCGKLT 3653
Query: 2401 ---ASLQESLEKHFSESMQEFQEWFLG---AKAAAKESSDRT----GDSKVLEAKLHDLQ 2450
+ QE LE +++F G A AA+E+ + +++ +L D +
Sbjct: 3654 ERGKARQEQLELTLGR-VEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFK 3712
Query: 2451 NI-LDSVSDGQSKLDAVTQEGQTLYAHLSKQI-VSSIQEQITKANEEFQAFLKQCLKDKQ 2508
+ V Q KL V GQ L K V ++ + + N + K+ +
Sbjct: 3713 MFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA 3772
Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
LQ+ G F+D L W+ + EE + Q P + +V K ++ +LL
Sbjct: 3773 QLQEALLHCGKFQDALEPLLSWLADTEELI-------ANQKPPSAEYKVVKAQIQEQKLL 3825
Query: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCS-QLLTSHQNLLRMTKEKLRSCQVALQEHE 2627
+ LD +L EG Q L + +T L +L S A Q+
Sbjct: 3826 --QRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQ- 3882
Query: 2628 ALEEAL---QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE------ 2678
LE+ L + + I D L+ E L + + + + ++IQ ++ E
Sbjct: 3883 -LEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENH 3941
Query: 2679 -VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWND 2737
++ A+ G+ ++ Q V+ ++++L+ +++I + L+ +S
Sbjct: 3942 ATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL 4001
Query: 2738 YVERKNQLEQWMESVDQKIEHPLQ---PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
+ E + ++ W+ V+ K+ Q L + DHL ++ E + + + + I
Sbjct: 4002 FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHA--DHL-ALNEEIVNRKKNVDQAI 4058
Query: 2795 AKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2851
+ L ++T E QE+L KT++ DI + + +R +E+ + + E
Sbjct: 4059 KNGQALLKQTTGEEVL-LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEE 4117
Query: 2852 FTDWLHSAKEELHRWSDMSGDSSAT-------QKKLSKIKELIDSREIGASRLSRVESLA 2904
T WL +EEL SG S T Q++ ++K+ + + ++ V
Sbjct: 4118 LTGWLREVEEEL----ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL 4173
Query: 2905 PEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQ 2964
E+ G + + ++ +K D++ Q ++ + + EQ ++A
Sbjct: 4174 LELVPWRAREGLDKLVSD---ANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAW 4230
Query: 2965 LEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTE--DLKSQ 3022
+ + + AL +Q D+ + + +D ++ + E +S+
Sbjct: 4231 VAETKRKLMALGPIRLEQ---------DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 4281
Query: 3023 LNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKE--QILQQRFRKAFRDFQQWL 3080
+ C + K LI++Y + L S+ E Q+L +F + + + W+
Sbjct: 4282 IFGTCG-EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWI 4340
Query: 3081 VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN-GQHK--LNMMLSKGELLSTLLTK 3137
+ A+ +P + Q+ +E E+ +HK ++ +L G L L
Sbjct: 4341 EETRALIAQ---LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE-LNP 4396
Query: 3138 EKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVH 3197
E+ + ++ K A+ + + Q+ AL+ Q + I+ L E +
Sbjct: 4397 EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL-- 4454
Query: 3198 ESSNRLYDLPAKRREQQKL-------QSVLEEIHCYEPQLNRLKEKAQQL------WEGQ 3244
S+RL P E K+ +S E+ +P LK + ++L +
Sbjct: 4455 --SSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512
Query: 3245 AASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLD 3304
A+K + ++ Q+ + + +E+ + ++ +F + L + D ++
Sbjct: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572
Query: 3305 SYCHPTSDKSVLDSRTLKLEALLSVKQEKE---IQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
P D S++ ++EA ++K+E + +++ I G ++ P +++
Sbjct: 4573 DLESPGIDPSIIKQ---QVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRK 4629
Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
+ + + W +L +LE A+ YQD ++ W+D+ L +
Sbjct: 4630 SIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4689
Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGM-------TEHYVTQLELQDLQERYR 3474
L L + K EV +E + +G M T+ + + L +L+ +
Sbjct: 4690 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4749
Query: 3475 AIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRD 3534
+ E+ K E + ++Q L+ WL +E LD + GD E L
Sbjct: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4809
Query: 3535 LQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRA------LESLRQDWQAYQHRLSE 3588
L+ QA + +V +++ S A D A LE++ Q W++ + E
Sbjct: 4810 HHVLKNDVLAHQATVETVNKAGNELLES---SAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
Query: 3589 TRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV 3648
Q + + + + + + L E ++S T QL + + ++
Sbjct: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4926
Query: 3649 TAYRDEVEEVGARAQEIL---DESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
A + ++ + + +L D+S S+ L ++ + ++ E+ LEE +
Sbjct: 4927 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALN 4986
Query: 3706 SLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLK 3765
E ++SL + +W ++ + ++TV+ +++ +V ++ +
Sbjct: 4987 LATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVL--SQIEEHKVFANEVNAHRDQII 5044
Query: 3766 SAREKGERAVKYLEEGEAERLRKEIHDHME-QLKELTSTVRKEHMTLEKGLHLAKEFSDK 3824
+ G + +K+L + + L K + ++ + +++ + +L+ AK+F +
Sbjct: 5045 ELDQTGNQ-LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103
Query: 3825 CKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALL 3884
K L W+ + + L E + + K QLSK+K Q+T+ +P + G AL
Sbjct: 5104 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALK 5163
Query: 3885 ELVQDVTLKDKIDQLQSDYQD----LCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
E K+D + +D +C E LE + + LQ + WL +
Sbjct: 5164 EKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYK 5223
Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA 4000
+ +L A D L+ + + HK +E+ + L+ G LI D
Sbjct: 5224 VEPQL-AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 5282
Query: 4001 KLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLS------- 4053
V LQ + +C + LE L++ +DT+ WLS
Sbjct: 5283 -----VKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337
Query: 4054 ---AVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCD------------ 4098
A+ D E + E +K+V+ R A +++ ++C
Sbjct: 5338 FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWIT 5397
Query: 4099 ---LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQN 4155
V T AK QQ +T +LV L + EL ++Q A+ L
Sbjct: 5398 IIRARFEEVLTWAKQHQQRLETALSELVANAELLE----------ELLAWIQWAETTLIQ 5447
Query: 4156 MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEH 4208
+ ++ + ++++ + F++++ KQ V+ + + +K P H
Sbjct: 5448 RDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIEPTH 5497
Score = 264 bits (675), Expect = 3e-69
Identities = 712/3997 (17%), Positives = 1515/3997 (37%), Gaps = 541/3997 (13%)
Query: 1856 ASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQN 1915
A+Q V RQL L H E L S+ SL LR T + E +L E L D L
Sbjct: 1793 ATQNVFTRQLCLEH-DEKLVSYLSL------LRNIEMRTKQIQPLELNLAE--LQDLLCQ 1843
Query: 1916 AKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADA 1975
AK LE L ++S+ E+E + ++ ++ E A
Sbjct: 1844 AKVLERELKDLTTLVSQ-------------------------ELECVNQIIISQPQEVPA 1878
Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
L KA + + L KS+ + + T RL ++ +V NQ +L +L
Sbjct: 1879 Q--LLKALEKDAKNLQKSLSSVSD-TWNSRLLHFQNAVEIEKTKVLNQ-HTQLEGRLQDL 1934
Query: 2036 -CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI--------- 2085
W+ +K + K +VD +N ++D K+ + E + Q L
Sbjct: 1935 RAWVGNKNLILNSKGSNSEIDVD-SLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISE 1993
Query: 2086 -----------DLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNK 2134
++R L+ + +LE ++ + Q + + + +N
Sbjct: 1994 HAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNT 2053
Query: 2135 MNYKQKDLDNFTSKGKHLL------------SELKKIHSSDFSLVKTDMESTVDKWLDVS 2182
+ + +DL ++ + + L S L+K + SD ++ D+++ + V
Sbjct: 2054 CHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQK-NQSDLKDLQDDIQNRATSFATVV 2112
Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFES 2242
+ +E M+ + LS ++ + R+++ Q E L R + KE E
Sbjct: 2113 KDIEGFMEENQTKLSP-RELTALREKLH--------QAKEQYEALQEETRVAQ--KELEE 2161
Query: 2243 EVKNKALRLEELHSKVNDLKELTKNLETPPD-LQFIEADLMQKLEHAKEITEVAKGTLKD 2301
V + + E +L E K ++ D + + + Q L + + +++ +L+
Sbjct: 2162 AVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEK 2221
Query: 2302 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSN-ISSTQ 2360
+T +N + E L ++ CE +K +EL SQQ N I +TQ
Sbjct: 2222 GALDTTDGYMGVN-------QAPEKL-----DKQCEMMKAR---HQELLSQQQNFILATQ 2266
Query: 2361 ENLNSLCRKYHSA--ELESLGRAMTGLIKKHEAVSQLCSKTQA----SLQESLEKHFSES 2414
L + H+ E + + + G +K+ + S S+ + +LQ+ L+K F +
Sbjct: 2267 SAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK-FLQD 2325
Query: 2415 MQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY 2474
+EF+ W ++ + + L + L + + V + L VT GQ +
Sbjct: 2326 HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVL 2385
Query: 2475 --------AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
+I + +++++ A E + A +C + L + F++
Sbjct: 2386 DMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADS 2445
Query: 2527 LNLWIHEME---ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL 2583
L W+ E E+ ++ + + E+ +++ L E E L K+++ +
Sbjct: 2446 LQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR--DI 2503
Query: 2584 LSEEGHGAGQEGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV 2640
+ EG A + +L+ Q+L E+ Q A+ + ++++E+L+S+ +
Sbjct: 2504 MEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSI 2563
Query: 2641 KAIQDRLACAE-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSN 2696
++ L + S+L S ++ L + QDI K E M + + +++
Sbjct: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVT----RFMETAD 2619
Query: 2697 KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2756
V+Q +L + + + + +S+L+ ++ Q + +L+Q+ME+ + +
Sbjct: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML 2679
Query: 2757 EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEE 2816
QP + F + L + + +++ L L+ + + +D Q
Sbjct: 2680 ASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN- 2738
Query: 2817 LKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSAT 2876
L+ F ++ KE+ + + + V F WL + + ++ S +
Sbjct: 2739 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP-TETSMSAKEL 2797
Query: 2877 QKKLSKIKELIDS--------REIGASRLSR----VESLAPEVKQNT------------- 2911
+K++ +K L+D EI S +E AP+ + T
Sbjct: 2798 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2857
Query: 2912 ----------TASGCEL-------------MHTEMQALRA----------------DWKQ 2932
T C++ +H ++L+A W +
Sbjct: 2858 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2917
Query: 2933 WEDSVFQTQSCLEN-----LVSQMALSEQEFSGQVAQ----LEQALEQFSALLKTWAQQL 2983
++ V ++ + + V A S + F ++ Q +++ E + LL T+
Sbjct: 2918 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2977
Query: 2984 TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQL-------NELCRFSRDLSTY 3036
K EE+ W + E+ A Q+ + E+ S L ++L + +
Sbjct: 2978 EAENWKKIQEELNSRWERATEVTVARQR---QLEESASHLACFQAAESQLRPWLMEKELM 3034
Query: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
G + L + N L Q + + Q + + F + +Q A+ D+ +
Sbjct: 3035 MGVLGPLSIDPNMLNAQ-----KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
Query: 3097 ISEVSTSLQKIQ----EFLSESENGQHKLNMMLSKG----ELLSTLLTKEKAKG----IQ 3144
S+V LQ I E + + +++ + K ELL L K +A G +Q
Sbjct: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
Query: 3145 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE---------VSAEPIQDWLSKTEKM 3195
+ ++ E K + S LE L ++K+ + + + ++D L K +
Sbjct: 3150 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 3209
Query: 3196 VHESSNRLYDLPAKRREQ--------QKLQSVLEEIHCY--------------EPQLNRL 3233
V L DL A R + Q+ Q + +E+ + +L RL
Sbjct: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
Query: 3234 KEKAQQLWEGQAA---------------------------SKSFRHRVSQLSSQYLALSN 3266
+ + Q+ E Q + ++ ++++ +L + + LS
Sbjct: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329
Query: 3267 LTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEAL 3326
T ++ SRL + + ++ +++L W+ D + S T D L+S L+ +A+
Sbjct: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLDPVQLESSLLRSKAM 3388
Query: 3327 LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
L+ + EK + I+ +L N+S + ++D A + +L+
Sbjct: 3389 LN-EVEKRRSLLEILNSAADILINSS-------EADEDGIRDEKAGINQNMDAVTEELQA 3440
Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLL 3446
+R+F ++E + E + E+ D + E++ + +L
Sbjct: 3441 KTGSLEEMTQRLREFQESFKNIEKKV-EGAKHQLEIFDALGSQACSNKNLEKLRAQQEVL 3499
Query: 3447 ETIEVK-------GAGMTEHYVTQLELQDL-------QERYRAIQERAKEAVTKSE-KLV 3491
+ +E + G+ E + L Q+ + +++R E KL
Sbjct: 3500 QALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLE 3559
Query: 3492 RLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQ-------ELQVHCAE 3544
+ Q + R + F L ++LD + D + ++ + D++ L++
Sbjct: 3560 GIGQFHCRVREMFSQ-LADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEA 3618
Query: 3545 GQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLME 3604
+A +L + G+ R LE+L + R + Q + ++
Sbjct: 3619 SEAECRHMLEEEGTLDLLGLK----RELEALNKQCGKLTERGKARQEQLELTLGRVEDFY 3674
Query: 3605 QKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWH-EEVTAYRDEVEEVGARAQ 3663
+K + +++ AEE + + + QL K + E+V + ++++V Q
Sbjct: 3675 RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ 3734
Query: 3664 EILDESHVN---SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3720
++ + + + ++ +R+ L +V ++I L+E + + + +L W
Sbjct: 3735 GLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSW 3794
Query: 3721 YGSTHK---NFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKY 3777
T + N K + + V + +KL L+ LL D + +L++ +G R +
Sbjct: 3795 LADTEELIANQKPPSAEYKVVKAQIQEQKL--LQRLLDDRKATVDMLQA---EGGRIAQS 3849
Query: 3778 LEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3837
E + E++ ++ + EL S LE L LAK+F + + ++ +++ ++
Sbjct: 3850 AELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEK 3909
Query: 3838 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV---TLKD 3894
L E + + + Q+ ++K+L++ + +H V + G++L L L +
Sbjct: 3910 KLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSE 3969
Query: 3895 KIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETS 3954
KID LQ+ Y ++ L+ + + + + EV WL ++ +L + ++
Sbjct: 3970 KIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-FVKDF 4028
Query: 3955 SLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTK 4014
+ + +Q A H A+ EEI + ++ G L+ Q +++ L G K
Sbjct: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK----LDGIK 4084
Query: 4015 DSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIK 4074
Y+ I T+ + ++LE Q Q T ++ WL V+ +L S ++ +
Sbjct: 4085 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG----GQSPTGE 4140
Query: 4075 QVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEE 4134
Q+ F+ Q++ + + + D N + + + + KLV N E+
Sbjct: 4141 QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN-----EQ 4195
Query: 4135 IKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVK-----KLQSKQASV 4189
K + + + + D +Q ++ + +A V++ K + +L+ Q +
Sbjct: 4196 YKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA--WVAETKRKLMALGPIRLEQDQTTA 4253
Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQRE-EDLQRTRDYHDCMNV 4248
++K + E+ + C + LQ + E L + + +N
Sbjct: 4254 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 4313
Query: 4249 --------VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ 4300
+V + +F ++ L+ E+ A+ + L A+ ++ + E+++ ++
Sbjct: 4314 ERYARLERAQVLVNQFWETYEELSPWIEETRAL-IAQLPSPAIDHEQLRQQQEEMRQLRE 4372
Query: 4301 KMIEH----------------LNLDDKELVKEQTSHLEQRWFQLEDLIKRK---IQVSVT 4341
+ EH LN ++ E+V+E+ E + Q+++ ++++ + +V+
Sbjct: 4373 SIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVS 4432
Query: 4342 NLEELNVVQSRFQELMEWAEEQQPNIAEALKQSP----PPDMAQNLLMDHLAICSELEAK 4397
++ + + ++E E N++ L+ P D + + D+ + ELE
Sbjct: 4433 QSTQITEFHDKIEPMLETLE----NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKL 4488
Query: 4398 QMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRR-----KYLNKA- 4451
Q ++L + + ++ ++ + K + D + + + R K+L+
Sbjct: 4489 QPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLE 4548
Query: 4452 LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4511
L+EK + MA T I+ + + E + P + +QV+ ++ + E+
Sbjct: 4549 LAEKFWYDMAALLTT--IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELE 4606
Query: 4512 GLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF 4571
+ G +L+ E EK EV + E+ + ++++ + RL++LE + + +++
Sbjct: 4607 FIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTL 4666
Query: 4572 DKACHWLKQADI--VTFPEINL-MNESSELHTQLAKYQ-NILEQSPEYENLLLTLQRTGQ 4627
WL I T P + +N + ++ +++ + +Q E E L G+
Sbjct: 4667 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL----NHQGE 4722
Query: 4628 TILP-SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE----- 4681
+L + +E D + E L L + + + +K++ A+LA ++ +E
Sbjct: 4723 LMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSW 4782
Query: 4682 LT-TQSLSE-----------LEAQFLRMSKVPTDLAVEEAL--SLQDGCRAILDEVAGLG 4727
LT T+ L + +E + + + D+ +A ++ +L+ AG
Sbjct: 4783 LTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-- 4840
Query: 4728 EAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMC 4787
D+ + + + Q W+ ++ + + + +Q S L+ + E E
Sbjct: 4841 ---DDASSLRSRLEAMNQCWE--------SVLQKTEEREQQLQSTLQQAQGFHSEIEDFL 4889
Query: 4788 QQLER---QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAP 4844
+L R QL + K + +++Y L + +L + + L
Sbjct: 4890 LELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML---LS 4946
Query: 4845 HLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVK 4904
D + K + + + +++S + E ++ E + + +FQ + ++WL +
Sbjct: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
Query: 4905 AELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELISADL 4963
L+ L L + +I + ++ EV + + L + KF K+ +
Sbjct: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066
Query: 4964 EHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGL 5023
++ S + +Q ++ R +L + + +++++ ++ DWLEDA
Sbjct: 5067 NLLVSVQSRWEKVVQRSIE-RGRSLDDARKRAKQFHEAWKKLIDWLEDA----------- 5114
Query: 5024 DVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQ 5083
E +L S +E + D+ L + TL GK Q V +R+
Sbjct: 5115 -----ESHLDSELEISNDPDKIKLQLSKHKEFQKTLG------GK----QPVYDTTIRTG 5159
Query: 5084 RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLS 5143
R ++ T D QK + + + K H+ EE L
Sbjct: 5160 RALKEK----------TLLPEDSQK----LDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
Query: 5144 EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQ-----RWTRLRAV 5198
+ + + + + +E + ++ + D V+Q R ++ +
Sbjct: 5206 FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL 5265
Query: 5199 AQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFV 5258
+ +++E++ D+ T ++++ + D + KL S + +A L + DT
Sbjct: 5266 KRSGRELIENSRDDTTWVKGQLQELSTRWDTVC-KLSVSKQSRLEQA-LKQAEVFRDTVH 5323
Query: 5259 LELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEK-VKTNGKL 5317
+ LE A +QTL GA P E L I ++ ++EK V N +
Sbjct: 5324 MLLEWLSEA-----EQTLRFR--GALPDDTEA--LQSLIDTHKEFMKKVEEKRVDVNSAV 5374
Query: 5318 VKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM 5377
E+ I ++K W+ TI I A+ EE+ LT A H+Q +E
Sbjct: 5375 AMGEVILAVCHPDCITTIKHWI----------TI-IRARFEEV---LTWAKQHQQRLETA 5420
Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
E L +L +Q AE L + ++ I I V+ A Q ++ +
Sbjct: 5421 LSELVANAELLEELLAW---IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRK 5477
Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
D+ + K K A +K G L + L Q+ +
Sbjct: 5478 QPDVDRVTKTYKRKNIEPTHAPFIEK----SRSGGRKSLSQPTPPPMPILSQS----EAK 5529
Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNE 5534
+I +L+ QQ A R KLN A LEE E
Sbjct: 5530 NPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5566
Score = 264 bits (674), Expect = 3e-69
Identities = 655/3421 (19%), Positives = 1371/3421 (40%), Gaps = 381/3421 (11%)
Query: 5419 EVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKL-M 5477
E ++ + L R I+ K + + L D + QAK VL EL + +
Sbjct: 1805 EHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAK----VLERELKDLTTLVSQ 1860
Query: 5478 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 5537
EL+ Q + Q ++ L K + K + Q+++ + + S L + +E
Sbjct: 1861 ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWN------SRLLHFQNAVE 1914
Query: 5538 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 5597
IEK KVL T LR ++ ++ L+ SK +SE++ + L
Sbjct: 1915 -----IEKTKVLNQHTQLEGRLQDLRA-WVGNKNLILNSKGSNSEIDVDSLNLCLQQYED 1968
Query: 5598 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA-KDMKKFEAELKK-LQAALEQAQATL 5655
+ M+++ A+L +++ I Q+L + M + EL++ Q LEQ A +
Sbjct: 1969 LKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQV 2028
Query: 5656 TSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRL 5715
+ + G L EQ + + L + + +++ LC S + E +A H
Sbjct: 2029 DALQ-GHLQQMEQEALVKTLQKQQNTCHQQLE--DLC-SWVGQAERALAG----HQGRTT 2080
Query: 5716 QEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQ 5775
Q++ S LQ ++ + + +K ++ +E ++ + + T+ ++L
Sbjct: 2081 QQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL-TALREKLH 2139
Query: 5776 AQISRHEELAQKIKGYQEQIA-SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGE 5834
++E L ++ + Q+++ ++ S + T K+K A + LAE + +D
Sbjct: 2140 QAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAA---------KELAENKKKIDAL 2190
Query: 5835 LLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANT-DASVN 5893
L S S G+ T L + + SG + + + D
Sbjct: 2191 LDWVTSVGSS-----GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCE 2245
Query: 5894 QDIAYYQALSAERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWET 5946
A +Q L +++ A T ++Q F + P + KLG+L+ + T
Sbjct: 2246 MMKARHQELLSQQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 2300
Query: 5947 LKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEH 6003
+ + + + QK+ + + +E E +L + G SPE S +
Sbjct: 2301 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 2360
Query: 6004 QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRM 6059
+ ++++ + ++ + S + L E+ + E + + L ER + +
Sbjct: 2361 GSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHS 2420
Query: 6060 KASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPM 6117
K + L LN L + Q ++ AD L +W+ + +A ++ LS +P
Sbjct: 2421 KCTR----LGSHLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPG 2470
Query: 6118 DMEAQLMDCQNMLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRR 6171
++ QL + + E+ + V + +L V + + +EG+ H ++ + + +
Sbjct: 2471 VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQS 2530
Query: 6172 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---Q 6228
L SL E + +L K + + QE ES QS G E + + + Q
Sbjct: 2531 LSYSLAE-RSSLLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQ 2584
Query: 6229 SSLQQQKELEQELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
+L +L+Q++A QKS L R + +R E +AA G E Q +
Sbjct: 2585 EALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQ 2644
Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
EK S+ ++ + E + + S K LQ +E + L G+ P
Sbjct: 2645 QEKESSLKKLLPQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPD 2686
Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
QD + + LN E+ +++++ + L +S+ LD + + V
Sbjct: 2687 QDITHFFQQIQELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2738
Query: 6406 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 6465
L + TE +E KD E++D+ + L + +++T G
Sbjct: 2739 -LRKDFTELQKTVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------ 2783
Query: 6466 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEA 6525
S+ + + +++++++ + + +D T + + + E + E
Sbjct: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAP 2838
Query: 6526 IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQN 6584
Q + G G G + +Q ++S + Y++L ++ R+ L
Sbjct: 2839 DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAI 2898
Query: 6585 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH--- 6640
L + + + LE+ +E + + +K E ++ + +K + LE +
Sbjct: 2899 LNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2958
Query: 6641 -MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---D 6695
+ E L ++++ +E + ++ + ++ +RA + V + LE + SHL
Sbjct: 2959 IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQ 3018
Query: 6696 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6755
+ +L L E + +G + + + L + Q + + + Q+ + +
Sbjct: 3019 AAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQG 3078
Query: 6756 LL-----ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 6810
+L +S+S S ++ +L + + W+ T+K++ +++ + T+YQ DL
Sbjct: 3079 ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK 3138
Query: 6811 LQSAKDRLEFWTQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQL 6866
+++ RL + Q V Q+LE + + + EV +AQ+ + G Q
Sbjct: 3139 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198
Query: 6867 LR---LKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 6923
L+ K+++T L L ++ D + + A Q Q E+ +W+
Sbjct: 3199 LKDELKKRLETVAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWL 3249
Query: 6924 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQ 6980
++ K N S + + LQ+ + F+ +N + + + +S+L +S
Sbjct: 3250 DDKQSQQAK---NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVP 3305
Query: 6981 DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFET 7040
E KR+ QL + W+ L ++ L+ ++ +Y+ +V+ L W E
Sbjct: 3306 PGEEKRT----LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361
Query: 7041 QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI- 7099
+ ++ + D ++++L + + + ++ + +E + LI + + D I
Sbjct: 3362 CKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIR 3421
Query: 7100 ---------VMSTLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINS 7144
+ + EL +L+ M +L+ +S + + + H++ FD + S
Sbjct: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 3481
Query: 7145 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 7204
+ +L + R L+A++ QVD L+N L + GS +QLL +
Sbjct: 3482 QACSNK-NLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVA 3536
Query: 7205 VTETLTNTLKEVNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQ 7250
E L EV R N+ ++E E + Q + +++ + D +
Sbjct: 3537 QQEFL-----EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRD 3591
Query: 7251 CASTVQQQEDRTNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
S Q ED L K K DI E +C +L+ GT+ D L EL
Sbjct: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEAL 3645
Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
KQ + + +QL L+ L +E K + G+ D T A+ EAL+ W+V
Sbjct: 3646 NKQCGKLTERGKARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVV 3697
Query: 7370 EAE-EILQGQDPSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 7427
E EI+ Q +D Q E+++ L+ ++ + + + L + G + E
Sbjct: 3698 GTEVEIINQQ----LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE- 3750
Query: 7428 KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SG 7485
M+ +N W+ ++ + +R ++LQ LL F + E + +L TE+ +A + S
Sbjct: 3751 HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA 3810
Query: 7486 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 7545
Y+ + Q + +L Q + R+ + + +G R+ + ++ DR++ +L L ++W
Sbjct: 3811 EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWT 3870
Query: 7546 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 7605
++ +A R+ ++ + +++ E AE + +L S S P+ Q A+
Sbjct: 3871 ELLSKAAARQKQLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQ 3927
Query: 7606 EVQFK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWK 7655
++ K E+ V+ G Q L S S AE +LQA +EIQ++
Sbjct: 3928 IIRHKALEEDIENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC 3986
Query: 7656 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAE 7710
+ L++ +D + +A+ +KL + FK+ + H L+ E
Sbjct: 3987 RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 4046
Query: 7711 QM-RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7769
+ R K ++ A+ + +LLK T + +++ ++ E+++ ++ ++ ++ S
Sbjct: 4047 IVNRKKNVDQAIKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSS 4095
Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAI 7828
+ + + F +EL WL ++E +++ +G E I + ++ +E
Sbjct: 4096 KALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKE 4155
Query: 7829 AQENKIQLQQMGERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETL 7884
E+++ L + E +++A E +A E ++ + N++++ + D I RV ++ +
Sbjct: 4156 VMEHRLVLDTVNE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214
Query: 7885 VAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7942
QQ ++ + W+A + +L PI + ++ +L Q+ DI +H
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDS 4271
Query: 7943 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 8002
+ + + + C + + +Q+ T +L +++ I ++ ER ++E L
Sbjct: 4272 MDELFSHRSEIFGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN 4327
Query: 8003 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
+F + Y W++ + A S + + +++ ++ + + E ++ + K
Sbjct: 4328 QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 4387
Query: 8063 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARD 8118
+L N + +MV E Q+ +N+ ++ +R+ L + Q + D
Sbjct: 4388 GPQLKELNPEEG-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442
Query: 8119 SILVWLTEMD----------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 8168
I L ++ L ++ EC I K+ E+ E +
Sbjct: 4443 KIEPMLETLENLSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKR 4497
Query: 8169 QGEQLIEKSEPLD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 8224
+GE+LI +S+ D A I+++LD++ + +++ R E +
Sbjct: 4498 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------E 4538
Query: 8225 RELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLE 8284
RE++ D L++ W+D +A L + + + ++ L P + + ++I E
Sbjct: 4539 REIKFLDVLELAEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE 4597
Query: 8285 WDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDD 8344
D L +LE G+ +K + ++ L ++ + L+D
Sbjct: 4598 TD---GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4654
Query: 8345 SRFQIQQTENIIRS----------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 8394
+ Q ++ +++ K T P + T L E V+ + ++
Sbjct: 4655 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQI 4712
Query: 8395 KEEEESLPGFVNLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQKWQQF 8445
+ E+ + G + L +T I R WE L + ++ +++ L QF
Sbjct: 4713 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
L + +WL TEE L+ + +S D + IE+++ K L+ V +A + ++N
Sbjct: 4773 QHALEELMSWLTHTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4830
Query: 8506 SPEFTQADS-KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 8564
E ++ + ++ L+ RL MN W+ V EE LQ L Q QGFH LL
Sbjct: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890
Query: 8565 MLENIDRRKNEIVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVASLQDMS 8616
L ++ + + P E L H + Q+K ++LL+ + +D S
Sbjct: 4891 ELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS 4950
Query: 8617 CQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSAD 8676
+ LE +K HV+ ++++ + S+ + L + +S Q+ +W +
Sbjct: 4951 GSGSKTEQSVALLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFINWLTLA 5005
Query: 8677 E 8677
E
Sbjct: 5006 E 5006
Score = 259 bits (663), Expect = 6e-68
Identities = 719/3921 (18%), Positives = 1514/3921 (38%), Gaps = 571/3921 (14%)
Query: 4366 NIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQ---- 4421
NI KQ P ++ L D L LE + L +L+ + + +++ Q
Sbjct: 1819 NIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPA 1878
Query: 4422 ----VIQKALSDAQSHVNCLSDLVGQRRKYLNKALS-EKTQFLMAVFQATSQIQQHERKI 4476
++K + Q ++ +SD R + A+ EKT+ L Q ++Q +
Sbjct: 1879 QLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWV 1938
Query: 4477 MFRE-----------------HICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRE 4519
+ ++CL + KQ + AQ + + E
Sbjct: 1939 GNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFI-----SE 1993
Query: 4520 LMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLK 4579
++++ Q+ ++L L ELQ + +L++ + ++ L+ +L ++
Sbjct: 1994 HAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQ--------------ME 2039
Query: 4580 QADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQ-RTGQTILPSLNEVDH 4638
Q +V L + + H QL +++ + E L Q RT Q L +L + +
Sbjct: 2040 QEALVK----TLQKQQNTCHQQL---EDLCSWVGQAERALAGHQGRTTQQDLSALQK-NQ 2091
Query: 4639 SYLSEKLNALPRQFNVIVALAKD--KFYKVQEAILARKEYASLIELTTQSLSELEA--QF 4694
S L + + + + + KD F + + L+ +E +L E Q+ + EA +
Sbjct: 2092 SDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEE 2151
Query: 4695 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLH 4754
R+++ + AV AL + E+A + +D L S+G ++L
Sbjct: 2152 TRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG-----GQLLT 2206
Query: 4755 LVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEK 4814
+ +L + ++ +L DTT Y + ++L++Q + +K ++E L ++
Sbjct: 2207 NLPGMEQLSGASLEKGAL--DTTDGYMGVNQAPEKLDKQCEMMKAR----HQELLSQQQN 2260
Query: 4815 LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGE 4874
+ A + D H +L P + + +Q GELK S
Sbjct: 2261 FILATQSAQAFLDQ---------HGHNLTP--------EEQQMLQQKLGELKEQYST--- 2300
Query: 4875 TVTECESRMVQSIDFQTEMSRSLD-------WLRRVKAELSGPVYLDLNLQDIQEEIRKI 4927
++ + E+ + Q Q E+ + L WL R + EL + + + +++
Sbjct: 2301 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 2360
Query: 4928 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE---LSELDGDIQEALRTR 4984
E+V +SHK +F D+E+S E SE+ +++ L+
Sbjct: 2361 GSFSEDV---------ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDA 2411
Query: 4985 QATLTEIYSQCQRY----------YQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKS 5034
T ++S+C R Y FQ + D L+ + + L ++ +
Sbjct: 2412 TERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGV 2471
Query: 5035 HMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKED---------LEQKVASLELRSQRM 5085
E +T Q L E V L + + + + +++ S+ Q +
Sbjct: 2472 LQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSL 2531
Query: 5086 SRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEH 5145
S + LLQ+ AQ Q++ E +++ + + E+ L E + + SS +E L+ +
Sbjct: 2532 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNL-EGKQVSSLSSGVIQEALATN 2590
Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
L + + A E ++ +T + + A L + V QR+ +L Q++E
Sbjct: 2591 MKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESS 2650
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
L+ + + F + K + ++ L + ++ + LE+E QQ
Sbjct: 2651 LKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQ---DITHFFQQIQELNLEMEDQQ 2707
Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDR 5325
L L + G A ++ QDR N+++ K VK+ KD
Sbjct: 2708 ENLDTLEHLVTELSSCGFA----------LDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2757
Query: 5326 EMVETQINSVKC-------WVQETKEYLGNPTI------EIDAQLEELQILLTE------ 5366
+ Q++ + W++ET+ + PT E++ Q+E L+ LL +
Sbjct: 2758 SSCQEQLDEFRKLVRTFQKWLKETEGSIP-PTETSMSAKELEKQIEHLKSLLDDWASKGT 2816
Query: 5367 --------ATNHRQNIEKMAEEQKEKYLGLYTILPSELSL-----------QLAEVALDL 5407
T+ I ++ + G +ILPS S L E+ D+
Sbjct: 2817 LVEEINCKGTSLENLIMEITAPDSQGKTG--SILPSVGSSVGSVNGYHTCKDLTEIQCDM 2874
Query: 5408 KIRDQIQDKIKEVEQSKATS-QELSRQIQKLAKDLTTILTKLKAK--------------- 5451
+ +K+ V + S Q + +++++ K+ ++L L++K
Sbjct: 2875 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTK 2934
Query: 5452 TDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ--NGQLGKPLAKKIGKLTELHQ 5509
T+ V K EL+ + K+ ++ A+ L N Q + K +L +
Sbjct: 2935 TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWE 2994
Query: 5510 QTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK----VLAHGTIAWNSASQLREQ 5565
+ R +L ++ASHL + + W+ + + VL +I N + ++Q
Sbjct: 2995 RATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQ 3054
Query: 5566 YILHQTLLEESKEIDSELEAMTEKLQYLTS-----VYCTEKMSQQVAELGRETEELRQMI 5620
Q +L+E + + E + E Q + + T ++ +++ + ++ EL +
Sbjct: 3055 V---QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKL 3111
Query: 5621 KIRLQNLQDAAKDMKKFEAELKKLQAA-------LEQAQATLTSPEVGRLSLKEQLSHRQ 5673
R + A +++ L+ L L A T PE ++K+QL
Sbjct: 3112 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE----AVKQQLEETS 3167
Query: 5674 HLLSEMESLKPKVQAVQ-LCQS-ALRIPEDVVASLPLCHAALRLQEEASRLQ---HTAIQ 5728
+ S++E L +V+ Q LC ++ I E + RL+ A LQ A
Sbjct: 3168 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD----ELKKRLETVALPLQGLEDLAAD 3223
Query: 5729 QCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKI 5788
+ N +QAA+ +Q++Q L+ ++ + ++ ++ LQ+Q+ +EE
Sbjct: 3224 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEE----- 3278
Query: 5789 KGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMM 5848
+Q+ + + +++ A+ ++LL+V E L +L+ + +
Sbjct: 3279 --FQKSLNQHSGSYEVIV--AEGESLLLSVPP----GEEKRTLQNQLVELKNHWEELSKK 3330
Query: 5849 TAGRCHTL----------------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 5892
TA R L L P E+ + + ++ P + S + + A +
Sbjct: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSKAML 3389
Query: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVIS 5952
N+ + S + AA I ++S E E G+ + ++ + + +
Sbjct: 3390 NE---VEKRRSLLEILNSAADILINSS---EADEDGIRDEKAG----INQNMDAVTEELQ 3439
Query: 5953 EKQRTLYEALERQQKYQDSLQSISTKMEAI--ELKLSESPEPGRSPESQMAEHQALMDEI 6010
K +L E +R +++Q+S ++I K+E +L++ ++ + + +A + +
Sbjct: 3440 AKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVL 3499
Query: 6011 LMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEE 6070
L+ +++ L+ + + LV ++ + A QL Q+ V + ++ + + ++E
Sbjct: 3500 QALEPQVDYLR-NFTQGLVEDAPDGSDASQLLHQA--EVAQQEFLEVKQRVNSGCVMMEN 3556
Query: 6071 KLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNML 6130
KL + + ++ C E+ S L LD + ++ +++Q+ D + L
Sbjct: 3557 KL----------EGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFL 3606
Query: 6131 -------VEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKL-RRLKGSLLELQRA 6182
++IE + L L G + + GKL R K +L+
Sbjct: 3607 NKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELT 3666
Query: 6183 LHD--------KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQ---RQSSL 6231
L K LN TA E+ E+ + T+ + + LA + +Q Q L
Sbjct: 3667 LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKL 3726
Query: 6232 QQ---------------------QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGD 6270
QQ + ++E+ A +L + VA R ++ E
Sbjct: 3727 QQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQL------QEALLH 3780
Query: 6271 AGEKPDVLSQELG--MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV--LY 6326
G+ D L L + E+ A + + + +QKLLQ +L+ + V L
Sbjct: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
Query: 6327 SRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---SIHLEQKL 6383
+ R+ L D+ +T L+ L + E+ S++ ++Q + L ++
Sbjct: 3841 AEGGRIAQSAEL-------ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3893
Query: 6384 YDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQA 6443
++ S +L E++L + P T+T Q+I+ K + E+++ + QA
Sbjct: 3894 HETAEPISDFLSVTEKKLANSE---PVGTQTAKIQQQIIRH--KALEEDIENHATDVHQA 3948
Query: 6444 FP--------ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKV 6495
+ + V+ + + L R S + ++ + + L F D
Sbjct: 3949 VKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 4008
Query: 6496 LFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGD------K 6549
+ LA+ + KL++VF + + + Q A+ + I+ K+ D +
Sbjct: 4009 VLNWLAE----VEDKLSSVFVKDFKQDVLHRQHADH--LALNEEIVNRKKNVDQAIKNGQ 4062
Query: 6550 LQVEQPSMQELSKLQD-------MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLL 6602
++Q + +E+ +Q+ Y ++ + L Q L ++++ ++L L
Sbjct: 4063 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWL 4122
Query: 6603 ETGQEKMA--GDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTET---LFRKIISFAVQ 6657
+E++A G Q + E+I Q + KE + + H ++ +T + R ++
Sbjct: 4123 REVEEELATSGGQS---PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPW 4179
Query: 6658 KETQFHTELMAQAS------------------AVLKRAHK----RGVELEYILETWSHLD 6695
+ + +L++ A+ A ++R+ + EL ++ ET L
Sbjct: 4180 RAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLM 4239
Query: 6696 E------DQQELSRQLEVVESSIPSVGLVEENEDRLIDRI-----TLYQHLKSSLNEYQP 6744
+Q + + QL+V ++ + +++ D L T + K+ L E
Sbjct: 4240 ALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE 4299
Query: 6745 KLYQVLDDGKRLLISISCSDLESQ---LNQLGEC------WLSNTNKMSKELHRLETILK 6795
L Q + LL S + LE +NQ E W+ T + +L +
Sbjct: 4300 SLIQQY-EAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 4358
Query: 6796 HWTRYQSESADLIHWLQSAKDR----LEFWTQQSVTVPQELEMVRDHL----NAFLEFSK 6847
+ Q E L + K L+ Q P+E EMV + N + + +
Sbjct: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418
Query: 6848 EVDAQSSLKSSVLSTGNQLLRL-KKVD--TATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
EV ++ +S Q+ K++ TL + SR+ + IPA +K+ +
Sbjct: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL-----RMPPLIPAEVDKIRE 4473
Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG------YKAIHEYLQKYKGFKI 6958
D ++ A E+ E + ++ E+ I S G K I + L + F
Sbjct: 4474 CISD---NKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWE 4530
Query: 6959 DINCKQLTVDFVNQSVLQISSQ--------------------DVESKRSDKTDFAEQLGA 6998
DI + + VL+++ + D+ES D + +Q+ A
Sbjct: 4531 DIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEA 4590
Query: 6999 MNKSWQILQGL-----------------------------VTEKIQLLEGLLESWSE--- 7026
+ GL + E E L ++W E
Sbjct: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE 4650
Query: 7027 -----------YENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKAK 7074
Y++ +Q + W + +L +G D +V++ L + ++ + + +
Sbjct: 4651 KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQ 4710
Query: 7075 EKEVEKIEQNGLALIQNKKEDVS-SIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWS 7133
+ E+EK+ G +++ ++ I+ L EL W NL + + L+ L
Sbjct: 4711 QIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALG 4770
Query: 7134 SHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSI 7193
+ A +++ S+L L R ++G + ++V++ L++D+ + +++
Sbjct: 4771 QFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4830
Query: 7194 TNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAS 7253
N+LL+ +L + L+ +N W ++L++ E+ Q ++ LQ Q + +
Sbjct: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890
Query: 7254 TVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGE-QLKQ 7312
+ + E + + + A +++ T + +L L +++ L + G L
Sbjct: 4891 ELTRMESQLSASKPTGGLPETAREQLDTHM----ELYSQLKAKEETYNQLLDKGRLMLLS 4946
Query: 7313 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 7372
+ D+ + S + L Q + + ++++ L+ + F SL+ W+ AE
Sbjct: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
Query: 7373 EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEIKRM 7430
+ L P S L+T+ ++EE K + ++ + L++ G +L +++ +
Sbjct: 5007 QSLNIASPP-SLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLI 5065
Query: 7431 QNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AVEIS 7484
+NL W + ++ ER L + + F E + +++L E L +EIS
Sbjct: 5066 KNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS 5125
Query: 7485 GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLLSNQ 7543
+ + Q H+ FQ + +Q + + I G+ L E+ + +D + + L + ++
Sbjct: 5126 NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDK 5185
Query: 7544 WQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL 7603
W V ++ +R+ ++ + ++ + + L WL +V ++ V L L
Sbjct: 5186 WDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE-PQLAEDQPVHGDLDLVMNL 5244
Query: 7604 FDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEE 7663
D + +K ++ G+ + +G++L+ ++ ++ +L E+ +W +
Sbjct: 5245 MDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDT-TWVKGQLQELSTRWDTVCKLSVS 5303
Query: 7664 QKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL--SQSLPDHHEELHAEQMRCKELENAV 7721
++ +L LK E + LE L ++ L +LPD E L + KE V
Sbjct: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363
Query: 7722 GSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNE 7781
D+ + + + A D I+ + + +++ ++EE+ +Q++ L+E
Sbjct: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 5423
Query: 7782 WAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIAQENKIQ 7835
+E +EL W+ E+ + Q I + I+++K + + EE+ Q + +
Sbjct: 5424 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 5483
Query: 7836 LQQMGERL------AKASHESKA-----------------SEIEYKLGKVND---RWQHL 7869
+ + +R A +S++ S+ E K ++N RWQ +
Sbjct: 5484 VTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQV 5543
Query: 7870 LDLIAARVKKLKETLVAVQQL 7890
L R +KL + L +++L
Sbjct: 5544 WLLALERQRKLNDALDRLEEL 5564
Score = 259 bits (662), Expect = 8e-68
Identities = 674/3768 (17%), Positives = 1459/3768 (38%), Gaps = 469/3768 (12%)
Query: 5161 ALEEKASQLEKTGNDASKATLSRSM----------TTVWQRWTRLRAVAQDQEKILEDAV 5210
ALE+ A L+K+ + S SR + T V + T+L QD +
Sbjct: 1883 ALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD--------L 1934
Query: 5211 DEWTGFNNKV---KKATEMID--------QLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5259
W G N + K + ID Q + L AE+ KA+L L F+
Sbjct: 1935 RAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER--KAQLDALAFDIQFFIS 1992
Query: 5260 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVK 5319
E Q S +Q L +L + ++ A+Q M+++ LVK
Sbjct: 1993 EHAQDLSP--QQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA-----LVK 2045
Query: 5320 QELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE 5379
K + Q+ + WV + + L Q Q L+ ++ +++ + +
Sbjct: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGH------QGRTTQQDLSALQKNQSDLKDLQD 2099
Query: 5380 EQKEKYLGLYTILPS-ELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLA 5438
+ + + T++ E ++ + L + +++K+ + ++ QE +R QK
Sbjct: 2100 DIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKEL 2159
Query: 5439 KDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLA 5498
++ T + +Q +T++ +EL K+ A+ ++ G G L
Sbjct: 2160 EEAVT----------SALQQETEKSKAAKELAENKKKI----DALLDWVTSVGSSGGQLL 2205
Query: 5499 KKIGKLTELHQQTIRQAE----NRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTI 5554
+ + +L ++ + + +NQA L++ EM++ + E + +
Sbjct: 2206 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKA--RHQELLSQQQNFIL 2263
Query: 5555 AWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETE 5614
A SA +Q+ H EE + + +L + E QY TS+ +E +QV L E
Sbjct: 2264 ATQSAQAFLDQHG-HNLTPEEQQMLQQKLGELKE--QYSTSLAQSEAELKQVQTLQDE-- 2318
Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQH 5674
LQ +D K+FE+ L++ + LE +SPE LK Q S +
Sbjct: 2319 ------------LQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSED 2366
Query: 5675 LLSEMESLKPKV---QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCN 5731
++S L+ Q V +++ + ++ L L+ E H+ +
Sbjct: 2367 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 2426
Query: 5732 I-MQAAVVQYEQYEQEMKHLQQLIEGAHREIED--KPVATSNIQELQAQISRHEELAQKI 5788
+ + QY Q++ LQ ++ +E S+ LQ Q++ ++L +++
Sbjct: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486
Query: 5789 KGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH-PSVVM 5847
+Q + L + + E+EG E + +H S+
Sbjct: 2487 AEHQVPVEKLQKVAR-------------DIMEIEGEPAPDHRHVQETTDSILSHFQSLSY 2533
Query: 5848 MTAGRCHTLLSPVTE-ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAER 5906
A R L + + +S +E S + S + +S++ + + +
Sbjct: 2534 SLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQ-NLEGKQVSSLSSGVIQEALATNMK 2592
Query: 5907 LQTDAAKIHPSTSASQEFYEPGLEP--SATA-----KLGDLQRSWETLKNVISEKQRTLY 5959
L+ D A+ S A++E +E S TA KL ++ + +E L EK+ +L
Sbjct: 2593 LKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLK 2652
Query: 5960 EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINE 6019
+ L + + ++ +S K++ S G P+ + + E+ + ++ E
Sbjct: 2653 KLLPQAEMFEH----LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQE 2708
Query: 6020 LQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQ 6079
+L E LV+E A L +R+ +R + ++ ++E+ D Q
Sbjct: 2709 NLDTL-EHLVTELSSCGFALDLCQHQ------DRVQNLRKDFTELQKTVKEREKDASSCQ 2761
Query: 6080 RQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPM----DMEAQLMDCQNMLVEIEQ 6135
Q L +R WL T+ ++ PP E ++E Q+ +++L +
Sbjct: 2762 EQ---LDEFRKLVRTFQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWAS 2813
Query: 6136 KVVALSELSVHN---ENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD-KQLNMQ 6191
K + E++ ENL++E T +++ G + GS + H K L
Sbjct: 2814 KGTLVEEINCKGTSLENLIME---ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL--- 2867
Query: 6192 GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ-QKELEQELAEQKSLLRS 6250
T + + SDV+L + GV +RQ SLQ +E+ E S+L+
Sbjct: 2868 -TEIQCDMSDVNLKYEKLGGV-----------LHERQESLQAILNRMEEVHKEANSVLQW 2915
Query: 6251 VASRGEEILIQHSA------AETSGDAGEKPDVLSQELGMEGEK-------------SSA 6291
+ S+ EE+L A ET E EL K +
Sbjct: 2916 LESK-EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP 2974
Query: 6292 EDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6351
Q W+ + +E +++ + V Q Q+ S + + +K +
Sbjct: 2975 NSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELM 3034
Query: 6352 TSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEE 6411
+L L+ + A++Q + K ++ L++ + + +
Sbjct: 3035 MGVLGPLS-----IDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
Query: 6412 TETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL--LGRLSLLD 6469
T + + + E++++++ + QA ++ +++++D + +G+ +
Sbjct: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
Query: 6470 SVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI----EA 6525
S ++ + +K++L++ ++DL+ L + + + + + + EQ + +++ E
Sbjct: 3150 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 3209
Query: 6526 IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNL 6585
+ GL++ A D++ Q ++ + Q M+DEL + ++S +N
Sbjct: 3210 VALPLQGLEDLAA---------DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260
Query: 6586 TLKSQYERALQDLADLLETGQE--KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMIL 6643
+ ++ ER L + E + + +G ++IV+ E + + +E
Sbjct: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE----------- 3309
Query: 6644 TETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSR 6703
TL +++ E + H E +++ +A + S L + Q+ +
Sbjct: 3310 KRTLQNQLV------ELKNHWEELSKKTA----------------DRQSRLKDCMQKAQK 3347
Query: 6704 QLEVVESSIPSVGLVEENEDRL---IDRITLYQHL---KSSLNEYQPK--LYQVLDDGKR 6755
VE +P + + L +D + L L K+ LNE + + L ++L+
Sbjct: 3348 YQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 3407
Query: 6756 LLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 6812
+LI+ S +D + + + + + T ++ + LE + + +Q ++ ++
Sbjct: 3408 ILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVE 3467
Query: 6813 SAKDRLEFWTQ--QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVL------STGN 6864
AK +LE + + LE +R +VD + ++ S +
Sbjct: 3468 GAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDAS 3527
Query: 6865 QLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWIS 6924
QLL +V R++S ++ KL + R S++
Sbjct: 3528 QLLHQAEVAQQEFLEVKQRVNS-------GCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
Query: 6925 LMENV--IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
++ + I +D D++++ I + + +L K K+DI + + +
Sbjct: 3581 ELDGMGAIGRDTDSLQSQI--EDVRLFLNKIHVLKLDIEASEAECRHMLE---------- 3628
Query: 6983 ESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 7042
E D +L A+NK L + + LE L ++ ++ L E
Sbjct: 3629 EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAE 3688
Query: 7043 KRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLA--LIQNKKED 7095
+ Q +G + + N Q L D ++++V+ ++ NGL LIQ+ +D
Sbjct: 3689 EAEALQWVVGTEVEIIN-----QQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKD 3743
Query: 7096 VSSIVMS-TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7154
+ + E+ W L+ V Q L+ L + A + + S+L + ++
Sbjct: 3744 CDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3803
Query: 7155 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7214
+ + + V+ Q+ + LQ L+ ++ ++ + ++ + E +T L+
Sbjct: 3804 NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLE 3863
Query: 7215 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7274
+ RW LL + A + + + +L L +++ + ++ + + E + T
Sbjct: 3864 SLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAK 3923
Query: 7275 ADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLC 7334
++ D+ V ++ ++G+ L + + SL
Sbjct: 3924 IQQQIIRHKALEEDIENHATDVHQAV----KIGQSLSSLTSPAEQGVLSEKIDSLQARYS 3979
Query: 7335 ALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQG-------QDPSHS--SD 7385
++ C++ L + + F + + W+ E E+ L QD H +D
Sbjct: 3980 EIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039
Query: 7386 LSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTT 7445
+ E + K + + L + G + L +++ ++ ++ SS+
Sbjct: 4040 HLALNEEIVNRKKNVDQAIKNGQALLK-QTTGEEVLLIQEKLDGIKTRYADITVTSSKAL 4098
Query: 7446 ERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-----QRAHELF 7500
+ + + Q+ E+ W+ + E++LA SG EQ QR EL
Sbjct: 4099 RTLEQARQLATKFQSTYEELTGWLR---EVEEELAT--SGGQSPTGEQIPQFQQRQKEL- 4152
Query: 7501 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7560
+ E+ + +L ++ + LLE R+ + ++ + Q++ V QR ID+
Sbjct: 4153 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 4212
Query: 7561 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD-EVQFKEKV-FLRQQ 7618
I++ Q+Y + A+ W+ E M+ LG PI L+Q +T +VQ + +R +
Sbjct: 4213 AIQRSQQYEQAADAELAWVAETKRKLMA-LG--PIRLEQDQTTAQLQVQKAFSIDIIRHK 4269
Query: 7619 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL----AFLLKD 7674
S ++ + + LQ + + +++++ S+ E+ +L + +
Sbjct: 4270 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 4329
Query: 7675 WEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLL 7734
WE E+ ++ +E+ R +L DH E+L +Q ++L ++ + +L +
Sbjct: 4330 WETYEE-LSPWIEETRALIAQLPSPAIDH-EQLRQQQEEMRQLRESIAEHKPHIDKLLKI 4387
Query: 7735 KDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV---FSEKNKE 7791
L ++ ++ ++ E+ + + + ++ ++ R + E +++ F +K +
Sbjct: 4388 GPQLKE-LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEP 4446
Query: 7792 LCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE-EIAIAQENKIQ-----LQQMGERLAK 7845
+ E L + S++ LI ++K+++ + + A + K+Q L++ GE L
Sbjct: 4447 MLETLENLSSRLRMPP--LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG 4504
Query: 7846 ASH----ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 7901
S + A EI+ KL ++ W+ + R K + L ++ +M++L T +
Sbjct: 4505 RSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTI 4564
Query: 7902 AHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7961
+ IV+D + + +Q E I++ + G+ L +L D
Sbjct: 4565 KDTQD-----IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4619
Query: 7962 TDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT 8021
+ E ++++ ++ W N+ ER K+E+ + ++ D DWL ++
Sbjct: 4620 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIK 4679
Query: 8022 AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE--NRTDSACSLK 8079
G K++L + + F+ +V++ ++E +N Q + ++ + TD ++
Sbjct: 4680 LCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI-IR 4738
Query: 8080 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 8139
+ + E W+NL +++ +L+ + +F+ A + ++ WLT + +L + +
Sbjct: 4739 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE-ELLDAQRPIS 4797
Query: 8140 CD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE---------- 8186
D ++ ++ + + ++ + +E + G +L+E S DA+ +
Sbjct: 4798 GDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4857
Query: 8187 ----EELDELRRYCQEVFGRVERYHKK----LIRLPLPDDEHDLSDRELELEDSAALSDL 8238
++ +E + Q + + +H + L+ L + + S L ++A L
Sbjct: 4858 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR-EQL 4916
Query: 8239 HWHDRSADSLLSPQPSSNLSLSLAQPLRSER----SGRDTPASVDSIPLEWDHDYDLSRD 8294
H L + + + N L + + R SG T SV + +W +
Sbjct: 4917 DTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEE 4976
Query: 8295 LESAMSRALPSEDEEGQDDKDFY-------------------LRGAVGLSGDH------- 8328
+S + AL E ++F L + +H
Sbjct: 4977 RKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEV 5036
Query: 8329 SALESQIRQLGKALDDSRFQIQQT----------------ENIIRSKTPTGPELDTSYK- 8371
+A QI +L + + +F Q+ E +++ G LD + K
Sbjct: 5037 NAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKR 5096
Query: 8372 ------GYMKLLG-------------ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 8412
+ KL+ E S+ D +K K KE +++L G ++ T
Sbjct: 5097 AKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 5156
Query: 8413 QTAGVI---------------------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNS 8451
+T + D+W+ + +++ ++ ++++ L QF L +
Sbjct: 5157 RTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQA 5216
Query: 8452 IWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQ 8511
+ WL E +L + Q + D+ + K+ QK + R + + E +
Sbjct: 5217 LVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIE 5274
Query: 8512 ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 8571
++ ++ +L +++ RWD VC L + L+ AL Q + F + H LL L ++
Sbjct: 5275 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 5334
Query: 8572 --RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCL 8629
R +P D+ + L D HK+ M+ ++ E ++ V S M ++++ DC+
Sbjct: 5335 TLRFRGALPDDTEA-LQSLIDTHKEFMK---KVEEKRVDVNSAVAMG-EVILAVCHPDCI 5389
Query: 8630 EA-KEKVHVIGNRLKLLLKEVSRHIKELEKLLD--VSSSQ--QDLSSW 8672
K + +I R + +L +H + LE L V++++ ++L +W
Sbjct: 5390 TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAW 5437
Score = 225 bits (573), Expect = 2e-57
Identities = 563/3336 (16%), Positives = 1277/3336 (38%), Gaps = 328/3336 (9%)
Query: 307 NSVQNFKREDRVIFKEMKVWIEQFERDLTRAQM--VESNLQDKYQSFKHFRVQYEMKRKQ 364
+ +QN + K+++ ++E+ + L+ ++ + L + ++ + + + +K+
Sbjct: 2099 DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKE 2158
Query: 365 IEHLI-QPLHRDGKLSLDQALVKQSWDRVTSRLFDWHI-------QLDKSLPAPLGTIGA 416
+E + L ++ + S + ++ ++ + L DW QL +LP GA
Sbjct: 2159 LEEAVTSALQQETEKSKAAKELAENKKKIDA-LLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
Query: 417 WLYRAEVALREE-ITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGI 475
L + + + + V Q E+ + +H++LL A +G
Sbjct: 2218 SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGH 2277
Query: 476 PVPPDQ-------LEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAE 520
+ P++ L ++ E++ + SE L +++ FL+ S L +E
Sbjct: 2278 NLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSE 2337
Query: 521 SKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA 580
+L++ E++ LL+ SF E+ ++ + + + + + + S +E
Sbjct: 2338 KELENMHKGGSSPETLPSLLKRQGSFSED---VISHKGDLRFVTISGQKVLDMENSFKEG 2394
Query: 581 ENVMKFMN-------ETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAE 633
+ + N + T ++ L + + S L ++ + ++ N+ SLQAW++ E
Sbjct: 2395 KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE 2454
Query: 634 KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWREL 693
+ E D + P +Q+ A + +E+ + + L R
Sbjct: 2455 ANV---EKLLSDTVASDPGVLQEQLATTK------QLQEELAEHQVPVEKLQKVAR---D 2502
Query: 694 FMEVKQYAQADEMDRMKKEYTDCVV----TLSAFATEAHKKLSEPLEVSFM---NVKLLI 746
ME++ D R +E TD ++ +LS E L + + S +++ L+
Sbjct: 2503 IMEIEGEPAPDH--RHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560
Query: 747 QDLEDIEQRVP-----------VMDAQYKIITKTAHLITKESPQEEGKEMF--------- 786
Q + ++EQ + + +A + + ++S E +EM
Sbjct: 2561 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2620
Query: 787 ATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLER--- 843
T + L+ +L +V + + L + Q+ L++L Q F GK+ + + R
Sbjct: 2621 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA 2680
Query: 844 ----EAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ----- 894
Q F Q+ QEL E+ ++ L +E + ++ +H D+
Sbjct: 2681 SGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLR 2740
Query: 895 ---TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFE---------ESRAELEKV 942
T LQ+ + + S ++ +++K V T + +K+ E S ELEK
Sbjct: 2741 KDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQ 2800
Query: 943 LRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAF------------------------ 978
+ + L++ L+ + L+ ++
Sbjct: 2801 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2860
Query: 979 LKACDELTDILPEQEQQGL--QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKN-----RF 1031
C +LT+I + L ++ LH++ + LQ +L+ +V K ++
Sbjct: 2861 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA-----ILNRMEEVHKEANSVLQW 2915
Query: 1032 LASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVR 1091
L S EE +D + E + + ++ F ++ + ++Q ++E L V
Sbjct: 2916 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQN---SPKIQKVKEALAGLLVT 2972
Query: 1092 DPVRDTPGTCHVTLKELRAAID-------STYRKLMEDPDKWKDYTSRFSEFSSWISTNE 1144
P +EL + + + R+L E + + S+ W+ E
Sbjct: 2973 YPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
Query: 1145 TQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLK-VLT---EVS-SENE 1199
+ + +ID K+ V+ + R + L + +LT +VS S ++
Sbjct: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ 3092
Query: 1200 AQKQGDELAKLSSSFKALVTLLSEVEKMLSN-FGDCVQYKEIVKNSLEELISGSKEVQEQ 1258
QK EL ++ + L L+ + QY+E++++ E++ + + + Q
Sbjct: 3093 VQK---ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
Query: 1259 AEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQ---------GEGGLPDR 1309
+ + T+ QQL ++T I + + ++ +AQ GE L D
Sbjct: 3150 S--AISTQPEAVKQQL-----EETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202
Query: 1310 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1369
+ L + L GLE + R+Q L ++F+ + + +L S +
Sbjct: 3203 LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI 3262
Query: 1370 SS-LESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLG---PQNKQLLQQQAKSIKE 1425
S+ LE L S+L++ +EF K + E +V E + L + K+ LQ Q +K
Sbjct: 3263 SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN 3322
Query: 1426 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1485
++L + ++ K + + E L WI + + +++ L + + ++ S
Sbjct: 3323 HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL 3382
Query: 1486 I--KVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCL 1543
+ K + E+E + S + L A E I+ + I + + + E Q
Sbjct: 3383 LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDG-IRDEKAGINQNMDAVTEELQAK 3441
Query: 1544 EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSA--TETYKVLQEHMDLCQA 1601
G++ + ++F+E+ + I++ V + +L + + S A + + L+ ++ QA
Sbjct: 3442 TGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA 3501
Query: 1602 LESLSSAITAFS----ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLL--- 1654
LE + F+ A + + +A QQ++ ++ +R +EN L
Sbjct: 3502 LEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561
Query: 1655 AHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGE---LQLIQALQNEVVSQAS 1711
+ +E+ S L L+ + D + + ++E L I L+ ++ + +
Sbjct: 3562 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA 3621
Query: 1712 FYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFD 1771
+L+ + +L + K +++ + +L ER + + + + ++ + + +
Sbjct: 3622 ECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLN 3681
Query: 1772 ELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLG 1831
+ + L + +E+ I++ Q+A + +K ++ LQ L ++
Sbjct: 3682 DATTAAEEAEAL---QWVVGTEVEIINQQLADFK--------MFQKEQVDPLQMKLQQVN 3730
Query: 1832 SLGRAEDLHLLQGKAEDC----------------FQLFEEASQVVERRQLALSHLAEFLQ 1875
LG+ L+Q +DC L ++ +Q + + Q AL H +F
Sbjct: 3731 GLGQG----LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF-- 3784
Query: 1876 SHASLSGILRQLRQTVE--ATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKA 1933
+L +L L T E A E +++ + + + L+ ++D + ++
Sbjct: 3785 -QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843
Query: 1934 QYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKS 1993
+ R + L + + +Q + + + VL K F + E +
Sbjct: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903
Query: 1994 IEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFA 2053
+ E++ +QQ++ LE+++ +H ++ +A +I Q +
Sbjct: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDV----HQAVKIGQSLSSLT 3959
Query: 2054 PEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM-----------REYQNLKSAVSKVL 2102
++ + L D + E Q +CC L+ + + + +++V
Sbjct: 3960 SPAEQGV--LSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
Query: 2103 ENASSVIVTRTTIKD--QEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2160
+ SSV V KD Q+ L + H ++ ++K++D G+ L LK+
Sbjct: 4018 DKLSSVFV-----KDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTT 4069
Query: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2220
+ L++ ++ ++ D++ + + L + + ST +E+ GW + ++
Sbjct: 4070 GEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW----LREV 4125
Query: 2221 AENISNLDNHLRAEELLKEF---ESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFI 2277
E ++ E + +F + E+K + + + VN++ L + +
Sbjct: 4126 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 4185
Query: 2278 EADLMQKLEHAKEITEVAKGTLKDFTA---QSTQVEKFINDITTWFTKVEESLM-----N 2329
+ + E K +++ + + A +S Q E+ + W + + LM
Sbjct: 4186 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 4245
Query: 2330 CAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKH 2389
Q++T L+ K ++ + ++ + + + + L LI+++
Sbjct: 4246 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 4305
Query: 2390 EAVSQLCSKTQASLQES--LEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2447
EA+S L S+ A L+ + L F E+ +E W +A + D + L +
Sbjct: 4306 EAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE 4365
Query: 2448 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2507
+++ + +S+++ + +D + + G L L+ + ++E+ KA + ++ +
Sbjct: 4366 EMRQLRESIAEHKPHIDKLLKIGPQL-KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 4424
Query: 2508 QALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGEL 2567
AL + S+ + H K+ + + ENL + P EV K+ + +
Sbjct: 4425 LALDEAVSQSTQITEFHDKIEPMLETL------ENLSSRLRMPPLIPAEVDKIRECISDN 4478
Query: 2568 LAARESLDK-------LSQRGQLLSEEGHGAGQE------GRLCSQLLTSHQNLLRMTKE 2614
+A L+K L +RG+ L GA ++ Q++ +++ +E
Sbjct: 4479 KSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEE 4538
Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
+ L+ E + ++ +K QD + ES G ++ K+ + + + +
Sbjct: 4539 REIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP-GIDPSIIKQQVEAAETIKEE 4597
Query: 2675 GEG-EVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVIS 2733
+G +L G + + + + ++ ++ + W ++ + LE +
Sbjct: 4598 TDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQ 4657
Query: 2734 QWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRL 2793
Y + + W+++ K+ L L+ ++ E + +L
Sbjct: 4658 AAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL 4717
Query: 2794 IAKSRELYEKTEDESFKDTAQE---ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
+ + +K DE+ +D +E ELK + ++ + K+E + + A+
Sbjct: 4718 NHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALE 4777
Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
E WL +E L +SGD + +L+K L + + + V E+ ++
Sbjct: 4778 ELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLES 4837
Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
+ + + ++A+ W+ + + L++ + Q E + +L +
Sbjct: 4838 SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMES 4897
Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
Q SA T T E +T E L + KA+ T + L S
Sbjct: 4898 QLSASKPTGGLPETAREQLDTHME-----------LYSQLKAKEETYNQLLDKGRLMLLS 4946
Query: 3031 RDLSTYSGK----VSGLIKEYNCLCLQASKGCQNKEQILQ--QRFRKAFRDFQQWLVNAK 3084
RD S K V+ L ++++ + + + E+ L F+ + ++F WL A+
Sbjct: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
Query: 3085 ITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQ 3144
+ ++ V + +++ + F +E + ++ + G L L K+ I+
Sbjct: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066
Query: 3145 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEK------MVHE 3198
+ + + W+ ++ +L++ + + K F + + + DWL E +
Sbjct: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
Query: 3199 SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLS 3258
+++ +K +E QK + ++ + R ++ L E +F + ++
Sbjct: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF---LGEVR 5183
Query: 3259 SQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHML--DSYCHPTSDKSVL 3316
++ + + E+ +L+ + QF ++ L DW+ L D H D L
Sbjct: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD---L 5240
Query: 3317 DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA 3376
+ + + K ++ R L S + ++ QLQ + W ++
Sbjct: 5241 VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKL 5300
Query: 3377 GIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
+ +S+LE AL + ++D V W+ E L
Sbjct: 5301 SVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 5336
Score = 209 bits (533), Expect = 7e-53
Identities = 571/3042 (18%), Positives = 1168/3042 (38%), Gaps = 431/3042 (14%)
Query: 5882 PSPVANTDAS----VNQDIAYYQALSAERLQTDAAKIHPSTSASQEFY-EPGLEPSATAK 5936
PS ++ TD S Q+ Y + + + +I S ++ Y E +P+ K
Sbjct: 1566 PSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLK 1625
Query: 5937 LGDLQRSWETLKNV----ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 5992
L ++ S K V S+++ ++ + K +L+S E K E P
Sbjct: 1626 LEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANP 1685
Query: 5993 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQ---------LAL 6043
+A +A E ++ Q L S L E+L + + Q L
Sbjct: 1686 N------VAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLET 1739
Query: 6044 QSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL----------------EEQRQEQ-ALQ 6086
TV S ++ + + + +L E ++Q E R Q
Sbjct: 1740 SEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFT 1799
Query: 6087 RYRC-EADE-LDSWL-LSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK---VVAL 6140
R C E DE L S+L L + T P E E Q + CQ ++E E K +
Sbjct: 1800 RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVS 1859
Query: 6141 SELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEES 6200
EL N+ ++ + + + L + L+ SL + + + L+ Q A E E++
Sbjct: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQN-AVEIEKT 1918
Query: 6201 DVDLTATQSPG----VQEWLAQARTTWTQQRQSS----------LQQQKELEQELAEQKS 6246
V TQ G ++ W+ + +S LQQ ++L+Q +AE+K+
Sbjct: 1919 KVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKA 1978
Query: 6247 LLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEG----EKSSAE-DQMRMKWES 6301
L ++A + + +H A + S + L EL E+++A+ D ++ +
Sbjct: 1979 QLDALAFDIQFFISEH-AQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQ 2037
Query: 6302 LHQEFSTKQ-KLLQNVLEQEQEQVL--YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGL 6358
+ QE K + QN Q+ E + + R L+G ++G QD SA+ L
Sbjct: 2038 MEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAG---HQGRTTQQDLSALQKNQSDL 2094
Query: 6359 NQAFEEVSSQSGG-------------------------AKRQSIHLEQKLYDGV-SATST 6392
+++ +++ A R+ +H ++ Y+ + T
Sbjct: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRV 2154
Query: 6393 WLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD--- 6449
++EE T+ L +ETE + AK++ E +++D + + G
Sbjct: 2155 AQKELEE---AVTSALQQETE-----KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLT 2206
Query: 6450 NRDVIEDTLGCLL--GRLSLLDSV--VNQ-------RCHQMKERLQQILNFQNDLKVLFT 6498
N +E G L G L D VNQ +C MK R Q++L+ Q + +
Sbjct: 2207 NLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQ 2266
Query: 6499 S----LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ 6554
S L + + + + + +Q + E E Q L + +A + +++ D+L Q
Sbjct: 2267 SAQAFLDQHGHNLTPEEQQMLQQKLGELKE---QYSTSLAQSEAELKQVQTLQDEL---Q 2320
Query: 6555 PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 6614
+Q+ + + + + + G + TL S +R D++ GD +
Sbjct: 2321 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI-----SHKGDLR 2375
Query: 6615 IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVL 6674
+ S Q++LD + +G E I L + + A ++ T H+
Sbjct: 2376 FVTISG---QKVLDMENSFKEGKEPSEI--GNLVKDKLKDATERYTALHS---------- 2420
Query: 6675 KRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV--GLVEENEDRLIDRITLY 6732
+ + G L +L + L ++ E+++ + V + L +++
Sbjct: 2421 -KCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATT 2479
Query: 6733 QHLKSSLNEYQ---PKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHR 6789
+ L+ L E+Q KL +V D + I + + + + LS+ +S L
Sbjct: 2480 KQLQEELAEHQVPVEKLQKVARD--IMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE 2537
Query: 6790 LETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE----------MVRDHL 6839
++L+ I QS ++ LE Q V Q LE ++++ L
Sbjct: 2538 RSSLLQ----------KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEAL 2587
Query: 6840 NAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQ 6899
++ +++ Q KSS+ +T + R + +T + L + V
Sbjct: 2588 ATNMKLKQDIARQ---KSSLEATREMVTRFMETADSTTAAVLQ----------GKLAEVS 2634
Query: 6900 EKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--------IHEYLQ 6951
++ QL + + ++ +++ + E++ K + ++N A I + Q
Sbjct: 2635 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQ 2694
Query: 6952 KYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVT 7011
+ + +++ +Q +D + V ++SS D +++ + K + LQ V
Sbjct: 2695 QIQELNLEMEDQQENLDTLEHLVTELSSCGF---ALDLCQHQDRVQNLRKDFTELQKTVK 2751
Query: 7012 EKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLI 7071
E+ + E E+ V+ + W + E + ++ ++ + L D
Sbjct: 2752 EREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW 2811
Query: 7072 KAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQ 7131
+K VE+I G +L +++M Q G+ +L SV
Sbjct: 2812 ASKGTLVEEINCKGTSL--------ENLIMEITAPDSQ---------GKTGSILPSVGSS 2854
Query: 7132 WSSHKVAFDKINSY-----LMEARYSLS----RFRLLTGSLEAVQVQVDNLQNLQDDLEK 7182
S +N Y L E + +S ++ L G L Q + + N +++ K
Sbjct: 2855 VGS-------VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2907
Query: 7183 QERSLQKFGSITNQLLKECHPPVTETLTNTLK---EVNMRWNNLLEEIAEQLQSSK-ALL 7238
+ S+ ++ ++LK + T T T+K E N + LE+ + ++Q K AL
Sbjct: 2908 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2967
Query: 7239 QLWQRYKDYS-----KQCASTVQQQEDRTNELLKAATNK-----------DIADDEVATW 7282
L Y + K+ + + +R E+ A + A+ ++ W
Sbjct: 2968 GLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW 3027
Query: 7283 IQDCNDLLKG-----------LGTVKDSLFFLHELGEQLKQQVD---------------- 7315
+ + +L+ G L K + F+ + E +QQ +
Sbjct: 3028 LME-KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 3086
Query: 7316 ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL 7375
+ + S +Q + S++Q L L + + + ++ + + L+ L + + L
Sbjct: 3087 SLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL 3146
Query: 7376 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRL-----------NELGYRLP--- 7421
Q S I + E +K Q+ + S + DL++L +EL +
Sbjct: 3147 SVQ--------SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198
Query: 7422 LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL---QHQTFLEKCETWMEFLVQTEQK 7478
L D+ KR++ + + +R ++LQ+ L Q Q ++ TW++ Q++Q
Sbjct: 3199 LKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD-KQSQQA 3257
Query: 7479 LAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQR-LLEQGQVDDRDEFNLKL 7537
IS + L Q + +E FQ + I+ +G+ LL +++ +L
Sbjct: 3258 KNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQL 3317
Query: 7538 TLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPL 7597
L N W+ + ++ R+ + +++ Q+Y+ E L W +E MS L P+
Sbjct: 3318 VELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPW-IEDCKAKMSELRVTLDPV 3376
Query: 7598 QQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQ------ 7651
Q +L +V R+ S + + + +L+++ E ++ E A I
Sbjct: 3377 QLESSLLRSKAMLNEVEKRR--SLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV 3434
Query: 7652 -EKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH-EELHA 7709
E+ ++ + LEE ++L + ++ EK + + +L F SQ+ + + E+L A
Sbjct: 3435 TEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA 3494
Query: 7710 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7769
+Q + LE V + + TQ L++D D S L + E+ Q+++ E+ +++
Sbjct: 3495 QQEVLQALEPQV-DYLRNFTQ-GLVEDA----PDGSDASQLLHQAEVAQQEFLEVKQRVN 3548
Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI---------------LIEEM 7814
+ +L F + +E+ L ++ ++ G I L
Sbjct: 3549 SGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNK 3608
Query: 7815 IEKLKKDYQEEIA-----IAQEN-------KIQLQQMGERLAKASHESKA--SEIEYKLG 7860
I LK D + A + +E K +L+ + ++ K + KA ++E LG
Sbjct: 3609 IHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLG 3668
Query: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
+V D ++ ++K L + A ++ + + T + I +LA ++ +
Sbjct: 3669 RVEDFYR--------KLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720
Query: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
+Q KL + L + + + D + ++ ++ RW
Sbjct: 3721 PLQMKLQQVNGLGQGL--------------------IQSAGKDCDVQGLEHDMEEINARW 3760
Query: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK 8040
+ +R +++E KF D WL +E A Y V K +++
Sbjct: 3761 NTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
Query: 8041 KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL 8100
+ + QR + + ++++ + R+A+ + + RW L + +
Sbjct: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
Query: 8101 RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SECDVQAKIKQLKAFQQEISL 8158
++L+ + ++F + I +L+ + +L N E +Q +I + KA +++I
Sbjct: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
Query: 8159 NHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL------IR 8212
+ + Q + G+ L + P + ++ E++D L+ E+ R R L R
Sbjct: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 4000
Query: 8213 LPLPDDEHDLSDRELELED---SAALSDLH---WHDRSADSLLSPQPSSNLSLSLAQPLR 8266
L +DE ++ + E+ED S + D H + AD L + N ++ Q ++
Sbjct: 4001 L-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 4059
Query: 8267 SERS--GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 8324
+ ++ + T V I + D D+ S+AL + ++ Q A
Sbjct: 4060 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ--------LATKF 4111
Query: 8325 SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSI 8384
+ L +R++ + L S Q E I P+ K K + E +
Sbjct: 4112 QSTYEELTGWLREVEEELATSGGQSPTGEQI--------PQFQQRQKELKKEVMEHRLVL 4163
Query: 8385 DSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ 8444
D+V + L E L + + + ++++L+ + + +Q+ QQ
Sbjct: 4164 DTVNEVSRALLE----LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
Query: 8445 FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINL 8504
+ ++ AW+ +T+ +L L + L D T +LQ++K + + H+ ++ +
Sbjct: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID-IIRHKDSMDELFSH 4278
Query: 8505 CSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 8564
S F ++ LQ++ + +++ + L E L+ A + F E L
Sbjct: 4279 RSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 4338
Query: 8565 MLENIDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VN 8622
+E + I + S +D E L+ +++ Q++ + E + + L + QL +N
Sbjct: 4339 WIE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN 4395
Query: 8623 AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 8664
E + +E EK N + +EV + L++ + S+
Sbjct: 4396 PEEGEMVE--EKYQKAENMYAQIKEEVRQRALALDEAVSQST 4435
Score = 199 bits (505), Expect = 1e-49
Identities = 435/2542 (17%), Positives = 998/2542 (39%), Gaps = 243/2542 (9%)
Query: 503 MEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 562
+++LE K +L + S K+ E+V+ ++ +F+ EQ Q
Sbjct: 2913 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAE---LEQNSPKIQK 2961
Query: 563 LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTV 622
+K+ + + +EAEN K E ++W + + + LEE S+ +
Sbjct: 2962 VKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 3021
Query: 623 ASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIE 669
+ L+ WL + E MLN + + + QQH +N+A ++
Sbjct: 3022 SQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT 3081
Query: 670 TCDE--MVSRDLKQQLLLLNGRWRELFMEV-KQYAQADEMDRMKKEYTDCVVTLSAFATE 726
+ + + ++++L +N +W EL ++ + +Q D+ +Y + + LS
Sbjct: 3082 GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRA 3141
Query: 727 AHKKLSEPLEVSFM--NVKLLIQDLEDIEQRVPVMDAQYK----IITKTAHLITKESPQE 780
++LS +S VK +++ +I + +D + K + + + LI ++ ++
Sbjct: 3142 VGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 3201
Query: 781 EGKEMFAT----MSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 836
E K+ T + L++ L +QQ +EL + K
Sbjct: 3202 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCP 3261
Query: 837 IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 896
I LER QS ++ Q+ L ++ ++ +G L +V ++
Sbjct: 3262 ISAKLER-LQSQLQENEEFQKSL--NQHSGSYEVIVAEGES------LLLSVPPGEEKRT 3312
Query: 897 LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKG-- 954
LQ Q+ ++ ++ + KKT D + ++ + +K++ +L + + + E
Sbjct: 3313 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 3372
Query: 955 -DPEEL---LRRHTEFFSQLDQRVLNAFLKACDELTDIL---PEQEQQGLQEAVRKLHKQ 1007
DP +L L R +++++R + L+ + DIL E ++ G+++ +++
Sbjct: 3373 LDPVQLESSLLRSKAMLNEVEKR--RSLLEILNSAADILINSSEADEDGIRDEKAGINQN 3430
Query: 1008 WKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD 1067
+ E L+ E + L +E ++++ EG+ K F
Sbjct: 3431 MDAVTEELQAKTGSLE---EMTQRLREFQESFKNIEKKV-----EGA----KHQLEIFDA 3478
Query: 1068 KGPHHLCEKRLQLIEELCVKLPVRDP------------VRDTPG------------TCHV 1103
G K L+ + L +P V D P
Sbjct: 3479 LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQ 3538
Query: 1104 TLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV 1163
E++ ++S + + + R E S ++ + +L G+ DT +
Sbjct: 3539 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT---DSL 3595
Query: 1164 KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSE 1223
+ +E++R L K + L +SE E + +E L L+ L E
Sbjct: 3596 QSQIEDVR---------LFLNKIHVLKLDIEASEAECRHMLEEEGTLD-----LLGLKRE 3641
Query: 1224 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLL-------- 1275
+E + G + + + LE + ++ + + + D E + L
Sbjct: 3642 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3701
Query: 1276 -LHHQQKTKRISAKKRDVQQQIAQAQQ----GEGGLPDRGHE--------ELRKLESTLD 1322
+ +QQ +K V + QQ G+G + G + ++ ++ + +
Sbjct: 3702 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3761
Query: 1323 GLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSELE 1380
L + ++ ++Q L +F+ E ++ +L T ++++ S + + + ++++
Sbjct: 3762 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS-AEYKVVKAQIQ 3820
Query: 1381 QTKEFSKRTESIAVQAENLVKEASEIPLGPQ--NKQLLQQQAKSIKEQVKKLEDTLEEDI 1438
+ K + + + L E I + +++ + Q +S++ + +L
Sbjct: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
Query: 1439 KTMEMVKTKWDHFGSNFETLSVWITEKEKELNALE---TSSSAMDMQISQIKVTIQEIES 1495
K +E + F E +S +++ EK+L E T ++ + QI + K ++IE+
Sbjct: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
Query: 1496 KLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGH-LSQQ 1554
+ + + QS + + E + K+ ++ E+++ C + +L LS
Sbjct: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC-CRKAALLDQALSNA 3999
Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL----ESLSSAIT 1610
+ F E+ ++ ++E EDKL+ ++ +H+ L + + +++ AI
Sbjct: 4000 RLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 4059
Query: 1611 AFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALE---NLLAHWQRLEKELS 1665
A ++ + + ++ ++ +Y DI + + LE L +Q +EL+
Sbjct: 4060 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELT 4119
Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
+L +E E A+S + +++ + Q + L+ EV+ + ++ +L
Sbjct: 4120 GWLREVE--EELATSGGQSPTGEQIPQFQQRQ--KELKKEVMEHRLVLDTVNEVSRALLE 4175
Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---- 1781
+ + + + +E+++ + I +R++ + + + QQ+++ + W+
Sbjct: 4176 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETK 4235
Query: 1782 -------KLFLSELQTTSEISIMD-HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSL 1833
+ L + QTT+++ + + + RHKD E+ S + E+ G+
Sbjct: 4236 RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI---------FGTC 4286
Query: 1834 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH----LAEFLQSHASLSGILRQLRQ 1889
G E +LQ K E Q +E S + R L + +F +++ LS + + R
Sbjct: 4287 GE-EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345
Query: 1890 TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY--HLKIGSSEQRTS 1947
+ S + L ++ + Q +++ +D +L L E
Sbjct: 4346 LIAQLPSPAIDHEQLRQQQ-EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 4404
Query: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
A+ + +++ EA + + F D+ E +L+++E++ R L
Sbjct: 4405 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 4464
Query: 2008 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREIN 2061
+++ + EL + LK + +++ A KD+A A E+ +++
Sbjct: 4465 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKEIQDKLD 4523
Query: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI-VTRTTIKDQED 2120
++ W+D K E + + +++L ++ +A+ +++ ++ + D
Sbjct: 4524 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI 4583
Query: 2121 LKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLD 2180
+K ET K + + ++L+ G L+ + + V+ ++ + W +
Sbjct: 4584 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE---VRKSIDEMNNAWEN 4640
Query: 2181 VSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCV------PQMAENISNLDNHLRAE 2234
+++ +E +++L ++ T + W +N V P + +++ + + L
Sbjct: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE- 4699
Query: 2235 ELLKEFESEVKNKALRLEELH-------SKVNDLKELTKNLETPPDLQFIEADLMQKLEH 2287
+KEF+ EV + + +E+L+ K D + E +L+ + +L +K+ H
Sbjct: 4700 --MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4757
Query: 2288 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL-----MNCAQNETCEALKKV 2342
+ E A L F + + ++ +W T EE L ++ L K
Sbjct: 4758 RQHKLEGALLALGQF-------QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
++ ++ + Q+ + + + N L + SL + + + E+V Q + +
Sbjct: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
Query: 2403 LQESLE--KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
LQ +L+ + F +++F ++ S G + +L + + +
Sbjct: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
Query: 2461 SKLDAVTQEGQ-TLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGS 2519
+ + +G+ L + S ++ + +++ + + K L++ +
Sbjct: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATE 4990
Query: 2520 FEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2579
F++ ++ W+ E+ N + + + E HKV F E+ A R+ + +L Q
Sbjct: 4991 FQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV--FANEVNAHRDQIIELDQ 5048
Query: 2580 RG---QLLSEEGHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEA 2632
G + LS++ Q+ L LL S Q+ +++ + E+ RS A + + EA
Sbjct: 5049 TGNQLKFLSQK-----QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103
Query: 2633 LQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL 2692
+ + W++ + L D ++ +LS+ ++ G + + I G +AL
Sbjct: 5104 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG-RAL 5162
Query: 2693 RSSN--KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWME 2750
+ E + + L +++ W + SV Q LE + +++ L W+
Sbjct: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222
Query: 2751 SVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFK 2810
V+ ++ L L+D + E T + L REL E + D++
Sbjct: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 5282
Query: 2811 DTAQ-EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2869
Q +EL T+++ + ++ K ++E+ +K ++ D VH +WL A++ L +
Sbjct: 5283 VKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL 5342
Query: 2870 SGDSSATQKKLSKIKELIDSRE 2891
D+ A Q + KE + E
Sbjct: 5343 PDDTEALQSLIDTHKEFMKKVE 5364
Score = 187 bits (475), Expect = 4e-46
Identities = 548/3186 (17%), Positives = 1207/3186 (37%), Gaps = 458/3186 (14%)
Query: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIED-KPVATSNIQELQAQISRHEELAQKIKGY 5791
+Q + Q + E+E+K L L+ +E+E + S QE+ AQ+ + L + K
Sbjct: 1837 LQDLLCQAKVLERELKDLTTLVS---QELECVNQIIISQPQEVPAQLLK--ALEKDAKNL 1891
Query: 5792 QEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG 5851
Q+ ++S++ + ++A + + + + L + T+ L+G L + G
Sbjct: 1892 QKSLSSVSDTWNSRLLHFQNA---VEIEKTKVLNQHTQ-LEGRLQD--------LRAWVG 1939
Query: 5852 RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDA 5911
+ +L+ +G+NSEI V + + + Q Q ++ + Q DA
Sbjct: 1940 NKNLILN-------SKGSNSEID----------VDSLNLCLQQYEDLKQPMAERKAQLDA 1982
Query: 5912 AKIHPSTSASQEFYE--PGLEPSATAKLGDLQRSWETLKNVISEK------------QRT 5957
S+ + P L +LQRS++ + + + Q
Sbjct: 1983 LAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA 2042
Query: 5958 LYEALERQQKY-QDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 6016
L + L++QQ L+ + + + E L+ GR+ + ++ Q ++ LQD+
Sbjct: 2043 LVKTLQKQQNTCHQQLEDLCSWVGQAERALAG--HQGRTTQQDLSALQKNQSDLKDLQDD 2100
Query: 6017 INELQSSLA------EELVSES-CEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE 6069
I +S A E + E+ + P E AL+ L E+ ++ + ++ LE
Sbjct: 2101 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 2160
Query: 6070 EKLNDQLEEQRQE----QALQRYRCEADELDSWLLST----------------------- 6102
E + L+++ ++ + L + + D L W+ S
Sbjct: 2161 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE 2220
Query: 6103 KATLDTA-----LSPPKEPMDMEAQLMDCQNM-LVEIEQKVVALSE-----LSVHNENLL 6151
K LDT ++ E +D + ++M ++ L+ +Q + ++ L H NL
Sbjct: 2221 KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNL- 2279
Query: 6152 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPG 6211
T +E + L KL LK A + +L T Q++ + +
Sbjct: 2280 ------TPEEQQMLQQKLGELKEQY-STSLAQSEAELKQVQTLQDELQKFLQ----DHKE 2328
Query: 6212 VQEWLAQARTTWTQQRQ---------SSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 6262
+ WL ++ + S L++Q +++ K LR V G+++L
Sbjct: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
Query: 6263 SAAETSGDAGEKPDVLSQELGMEGEKSSA--------EDQMRMKWESLHQEFSTK----- 6309
++ + + E +++ +L E+ +A + M HQ ++
Sbjct: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448
Query: 6310 ---------QKLLQNVL-------------------EQEQEQVLYSRPNRLLSGVPLYKG 6341
+KLL + + E + QV + ++ + +G
Sbjct: 2449 WMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEG 2508
Query: 6342 DVPTQDKSAVTSLLDGLNQAFEEVS---SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVE 6398
+ P D V D + F+ +S ++ +++I Q + + + + + +VE
Sbjct: 2509 E-PAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2567
Query: 6399 ERLF--VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIED 6456
+ L ++L + L L +DI ++ + + ++ F E D+
Sbjct: 2568 QNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTR-FMETADST----- 2621
Query: 6457 TLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFE 6516
T L G+L+ + Q C Q +E+ ++ LK L ++ L F
Sbjct: 2622 TAAVLQGKLAEVSQRFEQLCLQQQEK-------ESSLKKLLPQAEMFEH--LSGKLQQFM 2672
Query: 6517 QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGS 6576
+ + + + Q + + F I EL L++E + L L+ + EL
Sbjct: 2673 ENKSRMLASGNQPDQDITHFFQQIQELN-----LEMED-QQENLDTLEHLVTEL------ 2720
Query: 6577 RRSGLNQNLTLKSQYERAL---QDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY 6633
S L L +R +D +L +T +E+ D +E ++L+ +++
Sbjct: 2721 --SSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK-DASSCQEQLDEFRKLVRTFQKW 2777
Query: 6634 FQGLESHMILTETLFRKIISFAVQKETQFHTELM---AQASAVLKRAHKRGVELEYILET 6690
+ E + TET + + ++K+ + L+ A +++ + +G LE ++
Sbjct: 2778 LKETEGSIPPTET---SMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME 2834
Query: 6691 WSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVL 6750
+ D + S +PSVG + + Y H L E Q +
Sbjct: 2835 ITAPDSQGK--------TGSILPSVG-------SSVGSVNGY-HTCKDLTEIQCDM---- 2874
Query: 6751 DDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 6810
SD+ + +LG + L+R+E + K E+ ++ W
Sbjct: 2875 ------------SDVNLKYEKLGGVLHERQESLQAILNRMEEVHK-------EANSVLQW 2915
Query: 6811 LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL- 6869
L+S ++ L+ + +++ P + E V+ + F E++ S V LL
Sbjct: 2916 LESKEEVLK--SMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTY 2973
Query: 6870 -KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMEN 6928
+ + ++S+W A Q +L + + A S++ W+
Sbjct: 2974 PNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM---- 3029
Query: 6929 VIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD 6988
+++ + +G +I + + ++ K+ L ++Q + + D
Sbjct: 3030 ----EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGD 3085
Query: 6989 ----KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 7044
+ ++L ++N+ W L + + ++ + ++Y+ +Q L +R
Sbjct: 3086 VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQR 3145
Query: 7045 LKQQHRIGDQA-SVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSIVM 7101
L Q I Q +V+ L++ ++ ++ + EV++ + + L+++ ++ + +
Sbjct: 3146 LSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY-LKDELK 3204
Query: 7102 STLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTG 7161
L + L+ + L++ L + FD++ ++L + + ++ ++
Sbjct: 3205 KRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA 3264
Query: 7162 SLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE--TLTNTLKEVNMR 7219
LE +Q Q+ + Q L + S + + LL PP E TL N L E+
Sbjct: 3265 KLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV-PPGEEKRTLQNQLVELKNH 3323
Query: 7220 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADD-- 7277
W L ++ A++ K +Q Q+Y+ + + ++ + + +EL +
Sbjct: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383
Query: 7278 ---EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLC 7334
+ ++ LL+ L + D L E E I+ ++ ++Q++
Sbjct: 3384 RSKAMLNEVEKRRSLLEILNSAADILINSSEADED-----------GIRDEKAGINQNMD 3432
Query: 7335 ALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERME 7394
A+ + L + SL+ F +S + +E + A+ L+ D S S + +E
Sbjct: 3433 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSN--KNLE 3490
Query: 7395 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSF 7454
+L+ Q ++ P +D L +N + + ++ L
Sbjct: 3491 KLRAQQEVLQALEPQVDYL-----------------RNFTQGLVEDAPDGSDASQLLHQA 3533
Query: 7455 LLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQ--AEMFSRQQILH 7512
+ Q FLE + V E KL E G + R E+F A++ +
Sbjct: 3534 EVAQQEFLEVKQRVNSGCVMMENKL--EGIGQFHC-----RVREMFSQLADLDDELDGMG 3586
Query: 7513 SIIIDGQRLLEQGQVDDRDEFNLKLTLLS---NQWQGVIRRAQQRRGIID---------- 7559
+I D L Q Q++D F K+ +L + R + G +D
Sbjct: 3587 AIGRDTDSL--QSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEA 3644
Query: 7560 -----SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVF 7614
++ + + R+ +L VE Y + GL ++A L V + ++
Sbjct: 3645 LNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEII 3704
Query: 7615 LRQQGSYILTVEA---------------GKQLLLSADSGAEA-ALQAELAEIQEKWKSAS 7658
+Q + + + G+ L+ SA + L+ ++ EI +W + +
Sbjct: 3705 NQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764
Query: 7659 MRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD--HHEELHAEQMRCKE 7716
++ ++ +L L K + + L L ++ ++ P ++ + A+ K
Sbjct: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824
Query: 7717 LENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 7776
L+ + + L ++ D + ++E L+ +W EL + + R++Q+
Sbjct: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884
Query: 7777 ERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQE 7831
+ L F E + + ++L+ E K++ + + I++ I + K +E+I
Sbjct: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR-HKALEEDIENHAT 3943
Query: 7832 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 7891
+ Q ++G+ L+ + ++ + K+ + R+ + D + L + L +
Sbjct: 3944 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFG 4003
Query: 7892 KNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE 7951
++ + WLA +E +L+ V D + + R+ + L +I V + +
Sbjct: 4004 EDEVEVLNWLAEVEDKLSSVFVKDF-KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 4062
Query: 7952 VLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRF 8011
LL T E IQ+ + R+ +I S + +E+ +L KF Y
Sbjct: 4063 ALLKQ----TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEEL 4118
Query: 8012 EDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENR 8071
WL+ E A + ++ + +++V E L+ +N+ R L
Sbjct: 4119 TGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178
Query: 8072 TDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL 8131
+ L ++V + N+++ + + + + I + +++E A D+ L W+ E +L
Sbjct: 4179 WRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 4238
Query: 8132 TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 8191
++L ++EQ + ++K+ +D ++ +DE
Sbjct: 4239 ------------------------MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
Query: 8192 LRRYCQEVFGRVERYHKKLIRLPLPD--DEHDL-----SDRELELEDSAALSDLHWHDRS 8244
L + E+FG K +++ +++ S+R LE + L + W
Sbjct: 4275 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 4334
Query: 8245 ADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALP 8304
LSP +L P +PA +D L + R L +++ P
Sbjct: 4335 E---LSPWIEETRALIAQLP---------SPA-IDHEQLRQQQEE--MRQLRESIAEHKP 4379
Query: 8305 SED--------------EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQ 8350
D EEG+ ++ Y + ++ ++ ++RQ ALD++ Q
Sbjct: 4380 HIDKLLKIGPQLKELNPEEGEMVEEKYQKA----ENMYAQIKEEVRQRALALDEAVSQST 4435
Query: 8351 Q-------------TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE---HKL 8394
Q T + S+ P + + + + S+ +++L+ L
Sbjct: 4436 QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEAL 4495
Query: 8395 KEEEESLPGFVNLHSTETQTAGVIDR-------WELLQAQALSKELRMKQNLQKWQQFNS 8447
K E L G + + D+ WE ++A+A +E++ L+ ++F
Sbjct: 4496 KRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWY 4555
Query: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
D+ ++ + DT++ + L+ + I I+ Q++ + +++ D + I +
Sbjct: 4556 DMAALLTTIKDTQDIVHDLESPGIDPSI--IKQQVEAAETIKEETDGLHEELEFIRILGA 4613
Query: 8508 EFTQA-DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
+ A E +++ + +MN W+ + +E L+DA+ + + + L
Sbjct: 4614 DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4673
Query: 8567 ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA-EG 8625
+N + + P+ ++L+ ++D ++ + K E+ + Q+ + L +L A +
Sbjct: 4674 DNTVIKLCTMPPVGTDLNT--VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDE 4731
Query: 8626 TDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE--LD 8679
TD +E + + + + L ++++ +LE L + ++L SW + E LD
Sbjct: 4732 TDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLD 4791
Query: 8680 TSGSVS 8685
+S
Sbjct: 4792 AQRPIS 4797
Score = 128 bits (322), Expect = 2e-28
Identities = 348/1922 (18%), Positives = 743/1922 (38%), Gaps = 191/1922 (9%)
Query: 481 QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA--ESKLKSWIIKYGRRESVEQ 538
Q + ER EL L ++E K + L+ A E++ W++ E + Q
Sbjct: 3648 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT-EVEIINQ 3706
Query: 539 LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLS 598
L ++ F + + ++ Q + + +++ G + + + M E A+W L+
Sbjct: 3707 QLADFKMFQKEQ--VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764
Query: 599 VEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDF---------FRN 649
+V + L+E + + ++ + + L +WL D E+++ + ++ +
Sbjct: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824
Query: 650 LPHWIQQHTAMND----AGNFLIETCDEMVSRDLKQQLLLLNGRWRELFME-VKQYAQAD 704
L + A D G + ++ + + QL L RW EL + + Q +
Sbjct: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884
Query: 705 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL------EDIEQRVPV 758
++ + K++ + +S F + KKL+ V K+ Q + EDIE
Sbjct: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944
Query: 759 MDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKE--CYSPLLYESQQLLIP 816
+ KI + L SP E+G + + L+ + +++++ C L + Q L
Sbjct: 3945 VHQAVKIGQSLSSL---TSPAEQG-VLSEKIDSLQARYSEIQDRCCRKAALLD--QALSN 3998
Query: 817 LEELEKQMTSFYDSLGKI-NEIITVLEREAQSSALFKQKHQELLACQE---NCKKTLTLI 872
+ + L ++ +++ +V ++ + L +Q H + LA E N KK +
Sbjct: 3999 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ-HADHLALNEEIVNRKKNVDQA 4057
Query: 873 EKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKF 932
K Q++ K T VL +Q ++ I + + + + +E +L KF
Sbjct: 4058 IKNGQALLKQTTGEEVL------LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF 4111
Query: 933 EESRAELEKVLRIAQEGLEEKGDPE-------ELLRRHTEFFSQLDQR--VLNAFLKACD 983
+ + EL LR +E L G + +R E ++ + VL+ +
Sbjct: 4112 QSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR 4171
Query: 984 ELTDILPEQEQQGLQEAVRKLHKQWK---DLQGEAPYHL---------------LHLKID 1025
L +++P + ++GL + V ++Q+K D G+ + L
Sbjct: 4172 ALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 4231
Query: 1026 VEKNRFLASVEECRTELDRET-KLMPQEGSEKIIKEHRVFFSDKGPHH-----LC-EKRL 1078
E R L ++ R E D+ T +L Q+ I H+ + H C E++
Sbjct: 4232 AETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 4291
Query: 1079 QLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDS-TYRKLMEDPDKWKDYTSRFSEFS 1137
+++E L + E + ++S Y +L + + E S
Sbjct: 4292 TVLQEKTESL--------------IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 4337
Query: 1138 SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS- 1196
WI + + AID H ++++ EE+R E + LK+ ++
Sbjct: 4338 PWIEETRALIAQLPSPAID---HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 4394
Query: 1197 --------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1248
E + QK + A++ + L E + + E + +LE L
Sbjct: 4395 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 4454
Query: 1249 ISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
S + + + +KI E + + + + ++ A KR ++ I ++Q +
Sbjct: 4455 SSRLRMPPLIPAEVDKI--RECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512
Query: 1306 LPDRG-HEELRKLESTLDGLERSRERQERRIQVTLRKWERF--------ETNKET--VVR 1354
L + ++L ++ + ++ E +E + L E+F T K+T +V
Sbjct: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572
Query: 1355 YLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQ 1414
L G + + +E+ + E+T + E I + +L+ E K
Sbjct: 4573 DLESPGI--DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4630
Query: 1415 L------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKE 1468
+ + K+ KE+++KLED ++ ++ + ++ +D + L
Sbjct: 4631 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-------- 4682
Query: 1469 LNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKL 1526
+ + T + + Q++++K E+ + + L + + + T E+ R I+ L
Sbjct: 4683 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK-KATDETDRDIIREPL 4741
Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
T+++ E L E + + G L +F+ L ++ ++ E+ L I
Sbjct: 4742 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4801
Query: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDIL 1640
L +H L + + + + + + +++ + S A+ Q +E +L
Sbjct: 4802 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861
Query: 1641 RRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQ 1700
++ +ER+ L++ L Q E+ FL L R E++ S+ + E +L
Sbjct: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE-QLDTHM 4920
Query: 1701 ALQNEVVSQASFYSKLLQLKESLFSVASKDDV---KMMKLHLEQLDERWRDLPQIINKRI 1757
L +++ ++ Y++LL + + S+DD + + L+++W + + +R
Sbjct: 4921 ELYSQLKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4978
Query: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV--ALTRHKDHAAEVES 1815
+ L+ + +F L F W+ L L S S++ + V + HK A EV +
Sbjct: 4979 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 5038
Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ-VVER-RQL--ALSHLA 1871
+ ++ L +L L + +D+ L++ +E+ Q +ER R L A
Sbjct: 5039 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 5098
Query: 1872 EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILS 1931
+F ++ L L +++ ++ N+ D I+ L+ + K L D +
Sbjct: 5099 QFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 5157
Query: 1932 KAQYHLKIGSSEQRTSCRATADQLCGEV-ERIQNLLG---TKQSEADALAVLKKAFQDQK 1987
+ LK + S + D GEV ++ + G +Q + + + F D
Sbjct: 5158 TGR-ALKEKTLLPEDSQK--LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 5214
Query: 1988 EELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ 2047
+ L+ + +E + +++ + + + EL + LK +++ +
Sbjct: 5215 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 5274
Query: 2048 KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
V ++ L WD +L Q + + +++ + + L A
Sbjct: 5275 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 5334
Query: 2108 VIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSL 2166
+ R + D E L+ H+ K+ K+ D+++ + G+ +L+ H +
Sbjct: 5335 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILA---VCHPDCITT 5391
Query: 2167 VKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW----SNNCVPQMAE 2222
+K + ++ +V +++ RL +LS +E+ W + + E
Sbjct: 5392 IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 5451
Query: 2223 NI-SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELT-----KNLETPPDLQF 2276
I N+D R + L+ E ++ +EE+ K D+ +T KN+E P F
Sbjct: 5452 PIPQNID---RVKALIAEHQT-------FMEEMTRKQPDVDRVTKTYKRKNIE-PTHAPF 5500
Query: 2277 IE 2278
IE
Sbjct: 5501 IE 5502
Score = 117 bits (292), Expect = 7e-25
Identities = 325/1902 (17%), Positives = 768/1902 (40%), Gaps = 237/1902 (12%)
Query: 6918 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT------VDFVN 6971
+++S++SL+ N+ + + + + + L + K + ++ K LT ++ VN
Sbjct: 1809 KLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLEREL--KDLTTLVSQELECVN 1866
Query: 6972 QSVL----QISSQDVESKRSDKTDFAEQLGAMNKSW--QILQGLVTEKIQLLEGLLESWS 7025
Q ++ ++ +Q +++ D + + L +++ +W ++L +I+ + +L +
Sbjct: 1867 QIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK-VLNQHT 1925
Query: 7026 EYENNVQCLKTWFETQEKRL--KQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
+ E +Q L+ W + L K + D S+ L+ +DL+ + ++ +++ +
Sbjct: 1926 QLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAF 1985
Query: 7084 NGLALIQNKKEDVSSI----VMSTLRELG--------QTWANLDHMVGQLK-----ILLK 7126
+ I +D+S ++ L EL QT A +D + G L+ L+K
Sbjct: 1986 DIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVK 2045
Query: 7127 SVLDQWSSHKVAFDKINSYLMEARYSLS--RFRLLTGSLEAVQVQVDNLQNLQDDLEKQE 7184
++ Q ++ + + S++ +A +L+ + R L A+Q +L++LQDD++ +
Sbjct: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRA 2105
Query: 7185 RSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY 7244
S ++E ++ L+E L + EQ ++ + ++ Q
Sbjct: 2106 TSFATVVKDIEGFMEENQTKLSPRELTALREK-------LHQAKEQYEALQEETRVAQ-- 2156
Query: 7245 KDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLH 7304
K+ + S +QQ+ +++ + A NK D + D + +G+ L
Sbjct: 2157 KELEEAVTSALQQETEKSKAAKELAENKKKIDALL--------DWVTSVGSSGGQLLTNL 2208
Query: 7305 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEAL 7364
EQL A + ++Q L++ + Q + + F + ++
Sbjct: 2209 PGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSA 2268
Query: 7365 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLND 7424
+A++ + L ++ +Q+++ ELK Q L ++
Sbjct: 2269 QAFLDQHGHNLTPEEQQ------MLQQKLGELKEQY----------------STSLAQSE 2306
Query: 7425 KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEIS 7484
E+K++Q L +LQ FL H+ F E+W+E ++E++L
Sbjct: 2307 AELKQVQTLQ--------------DELQKFLQDHKEF----ESWLE---RSEKELENMHK 2345
Query: 7485 GNYQ-----HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-----DDRDEFN 7534
G LL++Q + F ++ S + L + I GQ++L+ + + N
Sbjct: 2346 GGSSPETLPSLLKRQGS---FSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 2402
Query: 7535 L---KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL----VEVSYLPM 7587
L KL + ++ + + + ++ + Q+ +++ A+ L+ W+ V L
Sbjct: 2403 LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLS 2462
Query: 7588 SGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA-LQAE 7646
+ S P LQ+ L Q +E++ Q L A + + + + +Q
Sbjct: 2463 DTVASDPGVLQEQ--LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET 2520
Query: 7647 LAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK-----KKLSQSLP 7701
I ++S S L E+ L + + ++ + L+ + + K++S
Sbjct: 2521 TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2580
Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD---ISILNERVELLQ 7758
+E A M+ K+ + L ++ ++ ++ D ++L ++ +
Sbjct: 2581 GVIQEALATNMKLKQ------DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVS 2634
Query: 7759 RQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKL 7818
+++E+LC Q + + + L + +F + +L +++ + +S++ +G+ +++
Sbjct: 2635 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM-ENKSRMLASGNQPDQDITHFF 2693
Query: 7819 KK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 7876
++ + E+ QEN L+ + L+ + + ++ + + L + R
Sbjct: 2694 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKER 2753
Query: 7877 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRD- 7935
K + + K + + + WL E + P S +++E+++++ + L D
Sbjct: 2754 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSI--PPTETSMSAKELEKQIEHLKSLLDDW 2811
Query: 7936 ------IEKHSTGVASVLNLC-EVLLHDCDACA------------------TDAECDSIQ 7970
+E+ + S+ NL E+ D T + IQ
Sbjct: 2812 ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2871
Query: 7971 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT--AAFPSSS 8028
+++ ++ + + ER+ ++ ++ + + WL+S E + SS
Sbjct: 2872 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSS 2931
Query: 8029 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-ARENRTDSACSLKQMVHEGNQ 8087
K + + +AF ++ + +++ + + L + A + K++ E N
Sbjct: 2932 PTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNS 2991
Query: 8088 RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL---------TNIEHFS 8138
RW+ + + R+L+ F+ A + WL E +L + N+ +
Sbjct: 2992 RWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 3051
Query: 8139 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8198
+ VQ +K+ +A +Q+ H ++ + AQG L + +++EL + + E
Sbjct: 3052 KQQVQFMLKEFEARRQQ----HEQLNEA-AQGILTGPGDVSLSTSQVQKELQSINQKWVE 3106
Query: 8199 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS-NL 8257
+ ++ ++ + + ++ ++L + A L S S +S QP +
Sbjct: 3107 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL-----SVQSAISTQPEAVKQ 3161
Query: 8258 SLSLAQPLRSE-----RSGRDTPASVDSIPLEWDHDY---DLSRDLESAMSRALPSED-E 8308
L +RS+ ++ D + + Y +L + LE+ ALP + E
Sbjct: 3162 QLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV---ALPLQGLE 3218
Query: 8309 EGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENI-IRSKTPTGPELD 8367
+ D+ L+ A+ + + ++R LDD Q QQ +N I +K
Sbjct: 3219 DLAADRINRLQAALASTQQFQQMFDELRTW---LDDK--QSQQAKNCPISAKLERLQSQL 3273
Query: 8368 TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQ 8427
+ + K L + S S + + L S+P + + Q + + WE L +
Sbjct: 3274 QENEEFQKSLNQHSGSYEVIVAEGESLLL---SVPPGEEKRTLQNQLVELKNHWEELSKK 3330
Query: 8428 ALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKE 8487
++ R+K +QK Q++ + + W+ D + ++ +L+ ++ D +E + + K
Sbjct: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKA 3387
Query: 8488 LQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQD 8547
+ V+ R++++ +N + + + ++D + +N D V L+ G L++
Sbjct: 3388 MLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEE 3447
Query: 8548 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES-Q 8606
+ + F E + + ++ K+++ D+ L ++ + + + ++ + E+L++ +
Sbjct: 3448 MTQRLREFQESFKNI---EKKVEGAKHQLEIFDA-LGSQACSNKNLEKLRAQQEVLQALE 3503
Query: 8607 LRVASLQDMSCQLLVNA-EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----- 8660
+V L++ + L+ +A +G+D + + V + + V+ +E L
Sbjct: 3504 PQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQ 3563
Query: 8661 ------DVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQ 8696
++ S DL DELD G++ GR T + Q
Sbjct: 3564 FHCRVREMFSQLADLD-----DELDGMGAI----GRDTDSLQ 3596
Score = 49.7 bits (117), Expect = 1e-04
Identities = 113/608 (18%), Positives = 233/608 (38%), Gaps = 90/608 (14%)
Query: 296 DEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQ---MVESNLQDKYQSFK 352
+E L F NS+Q F W+ E+ L A ++ + + + + K
Sbjct: 4982 EEALNLATEFQNSLQEFIN-----------WLTLAEQSLNIASPPSLILNTVLSQIEEHK 5030
Query: 353 HFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALV---------KQSWDRVTSRLFDWHIQL 403
F + R QI L Q ++ LS Q +V + W++V R + L
Sbjct: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090
Query: 404 D------KSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD 457
D K + WL AE L E+ + ++ I+ +L +HK+ +
Sbjct: 5091 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK----IKLQLSKHKEFQKTLG 5146
Query: 458 AHKRAFHEIYRT-RSVNGIPVPPDQ-------LEDMAERFHFVSSTS--------ELHLM 501
+ + RT R++ + P+ L ++ +++ V S E L
Sbjct: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLF 5206
Query: 502 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 561
+F++ L+ L E +L +G + V L+ + F K + T Q
Sbjct: 5207 SGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF---QKELGKRTGTVQ 5263
Query: 562 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 621
+LK++ + + S ++ V + E + +W + S +S LE+ + + + +T
Sbjct: 5264 VLKRSGRELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 5321
Query: 622 VASLQAWLEDAEKML-------NQSE------NAKKDFFRNLPHWIQQHTAMNDA---GN 665
V L WL +AE+ L + +E + K+F + + ++ +N A G
Sbjct: 5322 VHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVE---EKRVDVNSAVAMGE 5378
Query: 666 FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTL 720
++ C +K + ++ R+ E+ KQ+ Q E+ + + + +
Sbjct: 5379 VILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI 5438
Query: 721 SAFATEAHKKLSEPLEVSFMNVKLLIQD----LEDIEQRVPVMDAQYKIITK----TAHL 772
T ++ EP+ + VK LI + +E++ ++ P +D K + H
Sbjct: 5439 QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHA 5498
Query: 773 ITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYES----QQLLIPLEELEKQMTSFY 828
E + G++ + + + E +P + + QQ+ + E ++++
Sbjct: 5499 PFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5558
Query: 829 DSLGKINE 836
D L ++ E
Sbjct: 5559 DRLEELKE 5566
>gi|33624873 spectrin repeat containing, nuclear envelope 2 isoform 4
[Homo sapiens]
Length = 556
Score = 337 bits (863), Expect = 4e-91
Identities = 228/594 (38%), Positives = 315/594 (53%), Gaps = 65/594 (10%)
Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
+ED + W R S +PSS SL ERSG +TP SVDSIPLEWDH
Sbjct: 1 MEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHT 56
Query: 8289 YDLS------RDLESAMSRALPSEDEEGQDDKDFYLR---GAVGLSGDHSALESQIRQLG 8339
D+ D E AL D E ++ + YL+ + S S + +
Sbjct: 57 GDVGGSSSHEEDEEGPYYSAL--SDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVP 114
Query: 8340 KALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKE 8396
+ +Q E R+ P P T YK G + L + + L ++
Sbjct: 115 DSPSCPEHHYKQMEGD-RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQ 173
Query: 8397 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 8456
E+ L G Q +G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL
Sbjct: 174 EDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWL 224
Query: 8457 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 8516
TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S E
Sbjct: 225 KKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPE 284
Query: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG--------------FHEMSHGL 8562
S +LQ RL Q++ W+ ++ WRG L+ +LMQCQG FH++S L
Sbjct: 285 STELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNL 344
Query: 8563 LLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 8622
LL L + R+ + D D L + ++LMQ++ EL+E Q +V LQ++S LL+
Sbjct: 345 LLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIK 404
Query: 8623 AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSG 8682
G DC+EA+EKVHVI +LK L ++VS + L+ + +Q S S DE+D SG
Sbjct: 405 GHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNPASPLPSFDEVD-SG 457
Query: 8683 SVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLF 8742
P + P R K R R+T+G ++ PG R R FL
Sbjct: 458 DQPPATSVPAP-RAKQFRA---------------VRTTEGEEETESRVPGSTRPQRSFLS 501
Query: 8743 RVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8796
RV+RAALPLQLLLLLL+ LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 502 RVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 555
Score = 40.0 bits (92), Expect = 0.10
Identities = 59/295 (20%), Positives = 118/295 (40%), Gaps = 20/295 (6%)
Query: 5909 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 5968
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 157 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 213
Query: 5969 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 6023
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 214 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 273
Query: 6024 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 6083
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 274 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 332
Query: 6084 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6138
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 333 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 392
Query: 6139 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGT 6193
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 393 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGT 441
Score = 36.2 bits (82), Expect = 1.5
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 7864 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 7918
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 190 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 242
Query: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASV 7946
+EI+ ++ QE+ + + + V SV
Sbjct: 243 IQEIELRVKRLQEILKAFDTYKALVVSV 270
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 317 bits (811), Expect = 4e-85
Identities = 628/3216 (19%), Positives = 1229/3216 (38%), Gaps = 521/3216 (16%)
Query: 21 LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
++DE+E VQK+TFTKW+N+ +K + ++LF D++DG +LL LLE L+GQKLP E+G
Sbjct: 1 MEDEREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKG 59
Query: 81 RRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTS 140
R+HA+ N+ AL+ L+ + LVNI STDI DG + LGL+W IIL++Q++ +
Sbjct: 60 ST--RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMK 117
Query: 141 NLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEV 200
N+ + Q N++K LL WV+ + + V
Sbjct: 118 NI-----------------------------MAGLQQTNSEKILLSWVRQSTRNYPQVNV 148
Query: 201 KDFGKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPRLLDPE 259
+F SW G+A +++IH+ RP+L D +V +S + LE AF IA +LGI +LLDPE
Sbjct: 149 INFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPE 208
Query: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
DVD PD+KSI+ Y+ + P S + ++ E+LP P +E+
Sbjct: 209 DVDTTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------KEEHFQ 259
Query: 320 FKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLS 379
+ +Q L + S+ + +++S+ + + Y H
Sbjct: 260 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL----- 314
Query: 380 LDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETA 439
+A +S+ S L + + LD+ A L + +WL AE L+ + +
Sbjct: 315 --EAPEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI----SNDV 364
Query: 440 NTIQRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFVSSTSE 497
++ + H+ + + AH+ I + ++ + + D+ ++ E+ + ++S E
Sbjct: 365 EVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWE 424
Query: 498 -LHLMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVEQLLQN 542
L + ME +R+L L + K L W+ K R E +++ +Q
Sbjct: 425 CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQ 484
Query: 543 YVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWRNLSVE 600
+ E+ EQ +V L + ++ G A E +K + + +W N+
Sbjct: 485 HKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRW 538
Query: 601 VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 660
+L++++ W R AWL + E +N+ HT
Sbjct: 539 TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI-----------------HTTG 581
Query: 661 NDAGNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTD 715
N ++ + ++ + DL KQ + L ++L +K + + + +
Sbjct: 582 FKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFAR 641
Query: 716 CVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITK 775
C L + LE S + + + + VM+ + T+ L+
Sbjct: 642 C-----------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKH 690
Query: 776 ES-----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQMTSFYD 829
P + K S+++++L + E +S + L P + ++ +F D
Sbjct: 691 AQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSD 750
Query: 830 SLGKINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTLTLIEK 874
K+N I + + + AL +Q E + A ++ + + +
Sbjct: 751 LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 810
Query: 875 GSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK---- 930
S+ + +N++ ++Q + Q+ + + T +++ ++ K
Sbjct: 811 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 870
Query: 931 KFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKACDELTD 987
+ + ++E+ L+I L+EKG L F+ ++V + A K + D
Sbjct: 871 RLSGLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFD 929
Query: 988 ILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTELDR-E 1045
LP Q A+R W Q E + L + D E +E+ EL +
Sbjct: 930 TLPPMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGELQALQ 978
Query: 1046 TKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTL 1105
+ L Q+ + S K P + K EE+
Sbjct: 979 SSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI-----------------EGRW 1021
Query: 1106 KELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV-K 1164
K+L + + +KL E +K + + W++ + LK E E+ K
Sbjct: 1022 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGDSEILK 1077
Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
+ +++ R V+ + ++ L + E + + + + + ++L + K L T +
Sbjct: 1078 KQLKQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1133
Query: 1225 EKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF--------------- 1269
+ + KE +K LE+ +S K++ E E + E +
Sbjct: 1134 CQQV------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQK 1187
Query: 1270 ---EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLER 1326
E ++ QQK ++ V IAQA P E L+K TL
Sbjct: 1188 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL----- 1235
Query: 1327 SRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFS 1386
T +W N + + L + + LS+ LE + L + +
Sbjct: 1236 ----------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNEVEFKL 1281
Query: 1387 KRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1446
K TE+I AE E SE+ +N L + ++ Q++ L TL + E++
Sbjct: 1282 KTTENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMDELINE 1334
Query: 1447 KWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEE 1506
+ + F S + L ++K L S+ + + I+ ++ I+ +L++ + + +
Sbjct: 1335 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1394
Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEENLR-- 1562
A Q E+ +I++ LT EE+++H Q E +L + QK +++
Sbjct: 1395 AAQMPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1449
Query: 1563 -KIQQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQALESLSS 1607
++ Q + FE +L +K+ A ET V QE ++L ++L + S
Sbjct: 1450 FRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1509
Query: 1608 AITAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLE 1661
+ + R++V N + AL+ Y ++ + ER+ LE L +++
Sbjct: 1510 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1569
Query: 1662 KELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKE 1721
KE++ WL + + + + ++ E+ +A Q E+ Q + ++ E
Sbjct: 1570 KEMNVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGE 1628
Query: 1722 SLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI 1781
+L +V K + +++ L L+ W + + +N L + FD+ + + WI
Sbjct: 1629 ALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 1687
Query: 1782 KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHL 1841
+ L + + + L R K AE+ + ++ S + A +L
Sbjct: 1688 IQADTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA-----------NL 1733
Query: 1842 LQGKAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQLRQTV 1891
+ + + C +L E + R A+SH L E Q ++ + +L L
Sbjct: 1734 MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLE--A 1791
Query: 1892 EATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAT 1951
E +N E D KD+N+ N ++ D + +I +R +
Sbjct: 1792 EIQQGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKREEIKIK 1842
Query: 1952 ADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTR 2011
L + +++L ++ +A ++ ++ Q ++LLK ++DIE++ L EP
Sbjct: 1843 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASLPEPRD 1900
Query: 2012 QALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPE-----VDREINRLEVT 2066
+ R +++ EL + EL ++ +A+ +++ A A E + + +E
Sbjct: 1901 E------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK 1954
Query: 2067 WDDTKRL----IHENQGQCCGLI--DLMREYQNLKSAVSKVLENASSVIVTRTTI----- 2115
+ +RL IH + + ++ D+ E + S + + S ++ +
Sbjct: 1955 FAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD 2014
Query: 2116 ---KDQEDLKWAFSKHETAKNKMNYKQKD---LDNFTSKGKHLLSELKKIHSSDFSLVKT 2169
KD EDL F + E+ KN + Q+ +D SK L + +
Sbjct: 2015 LCAKDFEDL---FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2071
Query: 2170 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE-NISNLD 2228
++ +W V++ ++ R S+ W W + + I
Sbjct: 2072 QLDF---QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW 2128
Query: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL------ETPPDLQFIEADLM 2282
H + + LKE + + + + L++ ++ + + E L ++
Sbjct: 2129 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2188
Query: 2283 QKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE----SLMNCAQNETCEA 2338
++L K+ E K L +F ++ +N+ W + + L + + E
Sbjct: 2189 KQLSDRKKRLEEQKNILSEF-------QRDLNEFVLWLEEADNIASIPLEPGKEQQLKEK 2241
Query: 2339 LKKVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELES-LGRAMTGLIKKHEAV 2392
L++VK + +EL +Q + E +++ +LE+ L + IK A+
Sbjct: 2242 LEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRAL 2301
Query: 2393 SQLCSKTQASLQE--SLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQ 2450
+ + +A +++ LEK + ++ L + + + D+Q
Sbjct: 2302 PEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQ 2358
Query: 2451 NILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQAL 2510
+V Q ++ + +GQ LY K ++ ++ + E++A + + L++ +A
Sbjct: 2359 ETEIAVQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSSEWKA-VNRLLQELRAK 2415
Query: 2511 Q-DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL- 2568
Q D A L + T+ + Q + K+ + K+EM +L
Sbjct: 2416 QPDLAPGLTTIGAS---------------PTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2460
Query: 2569 ---------AARESLDKLSQRGQLLSEEGHGAG--------------------QEGRLCS 2599
A E D LS Q++ + G Q
Sbjct: 2461 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 2520
Query: 2600 QLLTSHQNLLRMTK------------EKLRSCQVALQEH-----EALEEALQSMWFWVKA 2642
+L+T+ QNL T E++++ +QEH + L E L+ W++A
Sbjct: 2521 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 2580
Query: 2643 IQDRLACAESTLG--------------SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKG 2688
++ AE LG + D ++K++++ + + + + +++A
Sbjct: 2581 KEE----AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA 2636
Query: 2689 EQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQW 2748
+ LR + + R + E + W I ++ LE + + W
Sbjct: 2637 LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW 2696
Query: 2749 MESVD---------QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE 2799
+ + + E L+ G+KE L+ Q + E E HT H L S++
Sbjct: 2697 LTEAETTANVLQDATRKERLLEDSKGVKE---LMKQWQDLQGEIEAHTDVYHNLDENSQK 2753
Query: 2800 LYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL---------MYLDAVH 2850
+ E Q L D M ++RK ++ HL ++L ++
Sbjct: 2754 ILRSLEGSDDAVLLQRRL-----DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL-SLQ 2807
Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLS---------KIKELIDSREIGASRLSRVE 2901
E WL +EL R + + GD A QK+ K KE + + R+ E
Sbjct: 2808 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2867
Query: 2902 --------------SLAPEVK-QNTT---ASGCELMHTEMQALRADWKQWEDSVFQTQSC 2943
L PE + QN T E ++TE + L W+ + +T
Sbjct: 2868 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDET--- 2924
Query: 2944 LENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTW 2979
LE L QE +L+ L Q + +W
Sbjct: 2925 LERL--------QELQEATDELDLKLRQAEVIKGSW 2952
Score = 215 bits (547), Expect = 2e-54
Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)
Query: 6732 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6791
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 766 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 816
Query: 6792 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6848
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 817 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 868
Query: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 869 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 927
Query: 6907 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6963
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 928 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 984
Query: 6964 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 7022
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 985 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1040
Query: 7023 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7081
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 1041 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1100
Query: 7082 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7141
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 1101 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1160
Query: 7142 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7201
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1161 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1220
Query: 7202 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7261
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1221 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1280
Query: 7262 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7321
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1281 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1330
Query: 7322 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1331 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1389
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7436
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1390 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1449
Query: 7437 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7496
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1450 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1495
Query: 7497 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7554
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1496 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1554
Query: 7555 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1555 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1612
Query: 7613 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7672
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1613 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1670
Query: 7673 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7723
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1671 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1725
Query: 7724 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7783
D L + + IS LN R + + H++ + I L E
Sbjct: 1726 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1776
Query: 7784 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7843
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1777 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1826
Query: 7844 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7902
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1827 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1886
Query: 7903 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7961
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1887 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1934
Query: 7962 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 8003
E IQ L +RWR I + RRL EET + +
Sbjct: 1935 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1989
Query: 8004 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 8057
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1990 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2045
Query: 8058 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 2046 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2105
Query: 8118 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 8176
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 2106 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2164
Query: 8177 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 8234
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2165 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2224
Query: 8235 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8291
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2225 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2283
Query: 8292 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 8338
L+ +SRALP E Q + + ++ L LE Q+ L
Sbjct: 2284 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2339
Query: 8339 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 8381
+ + F +Q+TE +++K P E+ + + + L + S
Sbjct: 2340 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2399
Query: 8382 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 8440
S +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK L M +L
Sbjct: 2400 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2458
Query: 8441 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 8498
+D N W L D L+Q+ + + + D++ I I K K + ++ R+
Sbjct: 2459 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2518
Query: 8499 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 8552
+ + + + ++E+R + DR+ ++ +WD V L+ R +L+D+
Sbjct: 2519 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2578
Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
+ E L ++ K +D+ +Q + Q+ +L + Q V
Sbjct: 2579 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2632
Query: 8613 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8661
D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2633 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2677
Score = 195 bits (496), Expect = 1e-48
Identities = 525/2901 (18%), Positives = 1111/2901 (38%), Gaps = 392/2901 (13%)
Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
+L + L ++ ++ W+ E+ + GE + K++ H E ++ +L
Sbjct: 325 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 382
Query: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2626
A + + + Q G L G + E + NLL E LR + Q H
Sbjct: 383 AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 438
Query: 2627 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2679
L + L+ + W+ ++R E D LE Q+Q +++ + E V
Sbjct: 439 RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 497
Query: 2680 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2739
++N SS ++ QL+ L + WA+I + L+ ++ +W
Sbjct: 498 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 557
Query: 2740 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2796
E + W+ + + G K++ +L LQ + ++ E +++ +L +
Sbjct: 558 EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 615
Query: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
++L +++S ++ + ++ ++K+E+ + + + +
Sbjct: 616 KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 661
Query: 2857 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916
+ + L + + M ++ T ++ +K + + R ++ E+++
Sbjct: 662 TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 721
Query: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976
EL H+ + A + E ++F+ + +L ++ E+E + + +L+ A AL+
Sbjct: 722 EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 780
Query: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
+ EG N D + +E L S+ E C+ + +
Sbjct: 781 EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 817
Query: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
+ +I YN L Q L+Q A + WL T P
Sbjct: 818 LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 854
Query: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3153
+ + + L+ ++ ++ Q ++ + + ++ KEK +G + A A
Sbjct: 855 PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 909
Query: 3154 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3209
+K S++ +E L+ + + ++ + I+ W+ S+T+ + + S Y++ +
Sbjct: 910 FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 969
Query: 3210 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3264
R E Q LQS L+E ++ + + +KA S+ ++ ++ ++ L
Sbjct: 970 RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1024
Query: 3265 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
S+ E +L+ + + + I+ L+ WM + L D +L + +
Sbjct: 1025 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1084
Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3384
L+S Q + + + G+ + PE ++ +L+ + W + K L
Sbjct: 1085 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1144
Query: 3385 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3427
+G L K S Q + + WM D ++ + E +R E + K
Sbjct: 1145 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1203
Query: 3428 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487
K KLL E V S + A + EL+ L Y+ + R
Sbjct: 1204 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1253
Query: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3547
E++ E L+ WL + + KL + G A L L+ L H +
Sbjct: 1254 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1313
Query: 3548 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY-------QHRLSETRTQFNNVVNKL 3600
+ + T D + + + LE+ W+ Q L ++ L
Sbjct: 1314 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1371
Query: 3601 RLMEQKFQQVDEWLKT-------AEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
L+++ +D+ L A + + QS+ + EI L +MKK ++ A +
Sbjct: 1372 HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1431
Query: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
+ ++ AQ+ L + + R+ + R Q + +L+++K +++ +
Sbjct: 1432 VLSQIDV-AQKKLQDVSMKFRLFQKPANFEQRLQESKM-ILDEVKMHLPALETKSVEQEV 1489
Query: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
+ S + + +K+ V ++++ V +KT G +
Sbjct: 1490 VQSQLNHCVNLYKSLSEVKSEVEMV--------IKT---------------------GRQ 1520
Query: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833
V+ + + L + + EL + V + LEK L L+++ + LT+W+A
Sbjct: 1521 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1580
Query: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVT 3891
L + ++++ K+ Q+ + + +KS+ E GEAL ++ ++
Sbjct: 1581 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1640
Query: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951
++DK+ L S++ + S +E + L K E ++ + + KW++Q A LL
Sbjct: 1641 VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ------ADTLL 1694
Query: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ-------AKLKQ 4004
+ S + Q+ K + E+ ++++ + + L+ DH + ++L
Sbjct: 1695 DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNH 1754
Query: 4005 NVHAHLQGTKDSYSAI--------CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ 4056
A K ++I S Q++ + LE E+Q+ V+ ++ + + +
Sbjct: 1755 RFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKE-----EDFNKDMN 1809
Query: 4057 PDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQ 4116
D E + + L R + ++Q R E+ R + + + + ++ KD++
Sbjct: 1810 EDNEGTVKELLQRGDNLQQ----RITDERKREEIKIKQQLLQTKHNAL----KDLR---- 1857
Query: 4117 TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVK 4176
Q+ +A ++ W + K +L L D +++L ++ E ++K
Sbjct: 1858 --SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE----------RKIK 1905
Query: 4177 DFVKKLQSKQASVNTIIEKVNKLTK------------------KEESPEHKEINHLNDQW 4218
+ ++LQ K+ +N + + L++ +E + + LN
Sbjct: 1906 EIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQ 1965
Query: 4219 LDLCRQSNNLCLQREEDLQ--------RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ R+ + + + L+ T H ++EV E+ D L D E
Sbjct: 1966 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV--EQLLNAPD-LCAKDFED 2022
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4330
E+LK + +LQ+ I+ + +K ++ ++ ++E S L+ +W ++
Sbjct: 2023 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2082
Query: 4331 LIK---RKIQVSVTNLEELNVVQSRFQELMEWAEE-----QQPNIAEALKQSPPPDMAQN 4382
+ K + SV + F + + AE+ Q P E K Q+
Sbjct: 2083 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2142
Query: 4383 LLMDHLAICSELEA--KQMLLKSLIKDADRVMADLG-LNER-QVIQKALSDAQSHVNCLS 4438
+ + L A ++++ +S DA + LG LN R Q + K LSD + +
Sbjct: 2143 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2202
Query: 4439 DLVGQRRKYLNKAL--SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4496
+++ + ++ LN+ + E+ + ++ + QQ + K+ E + LL +++ +
Sbjct: 2203 NILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL---EQVKLLVEELPLR---- 2255
Query: 4497 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE 4556
Q LK NE G + E EQ+K E KL++ + V + + E
Sbjct: 2256 ---QGILKQL-NETGGPVLVSAPISPE--EQDKLE--NKLKQTNLQWIKVSRALPEKQGE 2307
Query: 4557 LE---KNLVSRKHFKEDFDKACH----WL----KQADIVTFP-----------EINLMNE 4594
+E K+L + ED ++ + WL Q +I P EI + +
Sbjct: 2308 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2367
Query: 4595 SSELHTQLAKYQNILEQSPEYENL---LLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQ 4651
++ L+K Q++ ++ P + + L L + + L E L K L
Sbjct: 2368 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE-----LRAKQPDLAPG 2422
Query: 4652 FNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALS 4711
I A V + ++ ++ S +E+ + + E+ A ++ T+L + LS
Sbjct: 2423 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA-LADFNRAWTELT--DWLS 2479
Query: 4712 LQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTE---- 4767
L D + G E ++E+ K++ + +P ++ L+T LK +T
Sbjct: 2480 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP-QLEELITAAQNLKNKTSNQEA 2538
Query: 4768 -----QRVSLLEDTTSAYQEH-EKMCQQLERQLK------SVKEEQSKVNEETLPAEEKL 4815
R+ +++ QEH + QQL LK KEE +V + E
Sbjct: 2539 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 2598
Query: 4816 KMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD---PLAYEKARHQIQSWQGELKLLTS-- 4870
K ++Q K++ L ++D LA + R ++ ++T
Sbjct: 2599 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 2658
Query: 4871 -----AIGETVTECESRMVQS----IDFQTEMSRSLDWLRRVKAELSGPVYLDL----NL 4917
+I + V+E E+ + ++ F ++ + L WL +AE + V D L
Sbjct: 2659 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERL 2716
Query: 4918 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTK-AKELISAD----LEHSLAELSE 4972
+ + ++++ +++Q + + H E K + L +D L+ L ++
Sbjct: 2717 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2776
Query: 4973 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLE-DAQELLQLAGNGLDVESAEEN 5031
++++ ++ L Q +R + Q WL+ EL + A G D + ++
Sbjct: 2777 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2836
Query: 5032 LKSHMEF---FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL--ELRSQRMS 5086
H F T++ + E + T PL G E L Q+ L E R+Q ++
Sbjct: 2837 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL---EGLEKLYQEPRELPPEERAQNVT 2893
Query: 5087 RDSGAQVDLL----QRCTAQWHDYQKAREEVIELMNDTEK-------KLSEFSLLKTSSS 5135
R Q + + ++ D+Q+ +E +E + + ++ KL + ++K S
Sbjct: 2894 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2953
Query: 5136 -------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTV 5188
++ L + KAL + E + + + A QL G S LS ++ +
Sbjct: 2954 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDL 3012
Query: 5189 WQRWTRLRAVAQDQEKILEDA 5209
RW L+ +D+ + L +A
Sbjct: 3013 NTRWKLLQVAVEDRVRQLHEA 3033
Score = 191 bits (486), Expect = 2e-47
Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 6656
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 388 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 446
Query: 6657 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 6715
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 447 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 506
Query: 6716 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 6761
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 507 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 566
Query: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 567 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 623
Query: 6822 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6878
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 624 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 683
Query: 6879 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 6935
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 684 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 739
Query: 6936 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 6994
I G + +K + + K + ++S + Q V E +D A
Sbjct: 740 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 797
Query: 6995 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 7046
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 798 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 847
Query: 7047 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 7104
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 848 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 907
Query: 7105 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7164
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 908 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 965
Query: 7165 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7224
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 966 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1025
Query: 7225 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7284
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 1026 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1081
Query: 7285 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 7341
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 1082 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1138
Query: 7342 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 7401
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1139 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1197
Query: 7402 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 7454
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1198 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1257
Query: 7455 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 7512
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1258 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1313
Query: 7513 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 7572
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1314 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1371
Query: 7573 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 7631
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1372 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1418
Query: 7632 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1419 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1469
Query: 7689 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7746
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1470 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1529
Query: 7747 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 7806
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1530 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1589
Query: 7807 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7860
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1590 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1646
Query: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1647 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1695
Query: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1696 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1737
Query: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 8039
+ C +E ++ SE F + S I T A L
Sbjct: 1738 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1772
Query: 8040 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 8094
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1773 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1828
Query: 8095 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 8154
R+T + K +++K QQ
Sbjct: 1829 RITD--------------------------------------------ERKREEIKIKQQ 1844
Query: 8155 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 8214
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1845 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1896
Query: 8215 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8274
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1897 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1952
Query: 8275 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 8334
L + + + + M+ +P E +S S ++
Sbjct: 1953 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 1995
Query: 8335 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 8394
I + +AL +++Q N P+L C+ + + + E L
Sbjct: 1996 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 2030
Query: 8395 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 8434
K ++SL G ++ +HS +T Q+A ++R WE + ++ R
Sbjct: 2031 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2090
Query: 8435 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 8493
++++KW++F+ D+ WL + E+ L + Q E + K LKELQ +
Sbjct: 2091 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2145
Query: 8494 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2146 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2205
Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
F + +L LE D + +P++ + + L++ +Q+ + EL Q + L
Sbjct: 2206 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2262
Query: 8613 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 8659
+ +LV+A E D LE K K + L E+ IK+L +KL
Sbjct: 2263 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2322
Query: 8660 LDVSSSQQDLSSWSS 8674
D+ L W S
Sbjct: 2323 EDLEEQLNHLLLWLS 2337
Score = 187 bits (474), Expect = 5e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 5930 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5988
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 409 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 468
Query: 5989 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 6046
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 469 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 524
Query: 6047 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6104
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 525 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 572
Query: 6105 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6161
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 573 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 632
Query: 6162 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6213
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 633 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 688
Query: 6214 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6259
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 689 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 748
Query: 6260 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6303
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 749 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 808
Query: 6304 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6351
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 809 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 866
Query: 6352 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6385
+ L GL E + QS K + + H +Q D
Sbjct: 867 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 926
Query: 6386 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6431
+SA TW+ E +L + + E E L + L ++E
Sbjct: 927 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 986
Query: 6432 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6483
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 987 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1039
Query: 6484 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6542
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 1040 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1099
Query: 6543 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6596
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 1100 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1159
Query: 6597 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6652
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1160 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1218
Query: 6653 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6706
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1219 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1275
Query: 6707 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6762
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1276 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1325
Query: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1326 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1382
Query: 6823 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6871
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1383 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1442
Query: 6872 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 6914
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1443 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1502
Query: 6915 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 6956
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1503 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1562
Query: 6957 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 6986
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1563 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1622
Query: 6987 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 7033
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1623 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1682
Query: 7034 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 7086
+ W + L + + K Q ED++K + E V+
Sbjct: 1683 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1731
Query: 7087 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 7144
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1732 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1791
Query: 7145 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 7198
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1792 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1846
Query: 7199 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 7258
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1847 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1888
Query: 7259 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 7318
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1889 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1933
Query: 7319 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 7358
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1993
Query: 7359 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7416
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 1994 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2053
Query: 7417 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7473
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 2054 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2113
Query: 7474 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 7532
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 2114 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2172
Query: 7533 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2173 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2227
Query: 7593 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 7647
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2228 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2287
Query: 7648 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 7704
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2288 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2347
Query: 7705 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 7762
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2348 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2405
Query: 7763 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 7784
L +L ++ + L E A+
Sbjct: 2406 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2465
Query: 7785 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 7838
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2466 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2521
Query: 7839 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 7887
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2522 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2581
Query: 7888 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 7947
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2582 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2633
Query: 7948 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 8007
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2634 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2689
Query: 8008 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 8056
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2690 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2744
Query: 8057 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8115
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2745 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2804
Query: 8116 ARDSILVWLTEMDLQLT 8132
+ +LVWL D +L+
Sbjct: 2805 SLQELLVWLQLKDDELS 2821
Score = 179 bits (453), Expect = 1e-43
Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)
Query: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 6013
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 325 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 384
Query: 6014 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6073
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 385 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 442
Query: 6074 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6131
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 443 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 490
Query: 6132 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6176
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 491 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 550
Query: 6177 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6236
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 551 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 597
Query: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6295
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 598 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 639
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6355
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 640 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 688
Query: 6356 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 689 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 737
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6462
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 738 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 797
Query: 6463 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6514
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 798 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 853
Query: 6515 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6570
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 854 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 913
Query: 6571 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6622
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 914 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 973
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6678
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 974 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1033
Query: 6679 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6738
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 1034 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1089
Query: 6739 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6795
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 1090 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1149
Query: 6796 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6854
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1150 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1207
Query: 6855 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6914
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1208 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1265
Query: 6915 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6974
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1266 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1314
Query: 6975 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 7034
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1315 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1374
Query: 7035 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7085
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1375 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1432
Query: 7086 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7142
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1433 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1471
Query: 7143 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7202
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1472 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1526
Query: 7203 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7262
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1527 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1583
Query: 7263 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7319
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1584 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1637
Query: 7320 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7375
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1638 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1694
Query: 7376 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7429
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1695 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1748
Query: 7430 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7488
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1749 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1806
Query: 7489 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7548
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1807 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1854
Query: 7549 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7608
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1855 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1903
Query: 7609 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7668
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1904 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1961
Query: 7669 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7718
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1962 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2021
Query: 7719 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7765
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 2022 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2081
Query: 7766 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7820
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 2082 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2138
Query: 7821 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7880
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2139 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2198
Query: 7881 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7940
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2199 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2256
Query: 7941 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7995
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2257 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2312
Query: 7996 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 8037
+ +L +K D + WL + F I AK+
Sbjct: 2313 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2372
Query: 8038 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8086
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2373 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2431
Query: 8087 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8135
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2432 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2491
Query: 8136 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8194
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2492 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2551
Query: 8195 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8254
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2552 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2611
Query: 8255 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 8310
+ LA+ LR +W + D++ DL + R ++D
Sbjct: 2612 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2654
Query: 8311 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 8363
++ + +S +ALE R L + LD +F + + T N+++ T
Sbjct: 2655 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2714
Query: 8364 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 8417
L+ S K + L GE + D L+ ++ SL G + + + +
Sbjct: 2715 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2774
Query: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477
+W L+ ++L+ ++ + +W++ + L + WL ++EL + + + D
Sbjct: 2775 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2832
Query: 8478 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 8516
++ Q + ++ + ++ +I+S F E
Sbjct: 2833 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2892
Query: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 8576
+R L+ + ++N W+++ +W+ + + L + Q E + L L L + K
Sbjct: 2893 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2952
Query: 8577 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
P+ +L + LQDH +++ ++ E+ + V+ + D++ QL
Sbjct: 2953 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2994
Score = 179 bits (453), Expect = 1e-43
Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)
Query: 6799 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 6858
RYQ+ +++ WL SA+D L Q + ++E+V+D + + ++ A +
Sbjct: 335 RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 390
Query: 6859 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 6915
+L G++L+ +L + + ++ +++ ++S+W L Q LH++ MD
Sbjct: 391 ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 448
Query: 6916 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 6975
+ E+ W++ E +K E+ + + +Q++K + D+ +Q+ V+ + V+
Sbjct: 449 LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 507
Query: 6976 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 7035
+ D S EQL + W + ++ LL+ +L W
Sbjct: 508 VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 564
Query: 7036 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 7090
W +E + + H G DQ + ++L+ L+ ++ K++ + K+ +Q+ L+ ++
Sbjct: 565 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 624
Query: 7091 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 7121
NK +S V +T L QT + + +
Sbjct: 625 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 684
Query: 7122 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 7169
+IL+K ++ ++ D +++ + E ++R + S E A+ +
Sbjct: 685 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 744
Query: 7170 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 7218
N +L++ + ER +KF ++ Q++ E +++ +++N
Sbjct: 745 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 802
Query: 7219 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 7275
RW + ++E+L W Y++ + +QQ E T LK
Sbjct: 803 RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 854
Query: 7276 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 7335
+ + ++ C D + L ++ + L LK++ + +D ++ + H
Sbjct: 855 PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 912
Query: 7336 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7393
+ + ++ LQ L + +++ A+ W+ ++E L S +D +++R+
Sbjct: 913 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 971
Query: 7394 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 7447
EL+ L L+ E+ + P ++ K + + W +SSQ E
Sbjct: 972 GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 1031
Query: 7448 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 7505
KL+ + + + +T +++ + + L E G+ + L +Q + L +++
Sbjct: 1032 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1091
Query: 7506 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 7565
+ Q L+S+ GQ++ + + + +L L+ QW + ++ R+ + + +
Sbjct: 1092 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1151
Query: 7566 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 7623
++ ++ +W+ E YL P LQ+A +E++ ++ +++ L
Sbjct: 1152 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1208
Query: 7624 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 7683
E+ ++ A A+ AL+ EL + ++ RL + K L + W + +
Sbjct: 1209 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1268
Query: 7684 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 7741
+ + L FK K ++++P EE+ LEN + D+ Q+ +L TL+
Sbjct: 1269 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1325
Query: 7742 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 7801
D++ +NE +E +W EL H+ ++RRQ++ E+ + A +EK+ L
Sbjct: 1326 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1373
Query: 7802 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 7856
I+E + + K IA +K+ QM + K SHE E++
Sbjct: 1374 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1420
Query: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 7910
K + + Q +L I KKL++ + + K + + L ++ L
Sbjct: 1421 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1479
Query: 7911 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7970
+ S E +Q +LN L + + + + V V+ ++ +
Sbjct: 1480 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1534
Query: 7971 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 8030
+ L + + A ER+ ++E+ +L +K + + +WL +++ S+
Sbjct: 1535 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1594
Query: 8031 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 8085
+ + E+ +A Q+++ + L+ I + L +E + SL
Sbjct: 1595 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1648
Query: 8086 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 8145
N W + R L L + E F+ D I W+ + D L E +
Sbjct: 1649 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1708
Query: 8146 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 8205
+K+LKA +I K++ Q L+ ++E ++ EL + R++
Sbjct: 1709 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1765
Query: 8206 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 8260
+ L D L E E++ L + ++ D + D+ + + +
Sbjct: 1766 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1825
Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 8319
L Q + ER + + + ++ +DL S +AL + Q Y R
Sbjct: 1826 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1876
Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
A L +E ++ L + D+ + I++ + ++ K + +G + G
Sbjct: 1877 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1933
Query: 8380 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 8439
+ + +L + +E E F L+ + T V + ++ + + E+ +
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1991
Query: 8440 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 8499
+ +++ + L + E+ L + D + + Q + LK ++ ++ I
Sbjct: 1992 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 2044
Query: 8500 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 8556
I+ Q+ + R LQ+ LSQ++ +W++V + ++ +G ++ + + FH
Sbjct: 2045 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2104
Query: 8557 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 8615
++ + L E R+ I N + + + K+L + + Q V +L
Sbjct: 2105 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2157
Query: 8616 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 8674
+++ + TD +EK+ + R + + K++S K LE+ ++ S Q+DL+ +
Sbjct: 2158 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2217
Query: 8675 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 8702
+E D S+ G+ ++K + K
Sbjct: 2218 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2246
Score = 179 bits (453), Expect = 1e-43
Identities = 533/2827 (18%), Positives = 1093/2827 (38%), Gaps = 366/2827 (12%)
Query: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5311
H+ ++++L Q +G + Q ++ G + EE + +++ + R CL +
Sbjct: 374 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 432
Query: 5312 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5370
K +N V +L+++++ E + W+ +T+E +E + +L+ L + H
Sbjct: 433 KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 485
Query: 5371 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5426
+ E + +EQ + L ++ E S A AL+ +++ D+ + + E
Sbjct: 486 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 545
Query: 5427 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5486
Q++ + Q+L ++ L K D V + T E+ KL L A ++K
Sbjct: 546 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 604
Query: 5487 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5546
+ +GKL L Q + +N+ S + + L+ + + +++ +EK
Sbjct: 605 ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 652
Query: 5547 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5606
S +Q+ + Q L + T ++ +T+V E++ +
Sbjct: 653 -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 690
Query: 5607 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
A+ EEL + + + ++ K+ + ++ +L + + +++A L SPE +
Sbjct: 691 AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 745
Query: 5667 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5725
S + ++ +E + K + + Q A R + +V + A +++ + +L
Sbjct: 746 GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 803
Query: 5726 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5779
I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S +++Q+
Sbjct: 804 WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 863
Query: 5780 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5839
++ ++ G Q QI L K + + +K K +G LD + +
Sbjct: 864 ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 907
Query: 5840 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5892
+ V R L L P+ + + + S ++ TD +
Sbjct: 908 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 967
Query: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5950
Q + QAL + + + + ST+ + + E S ++ +++ W+ L +
Sbjct: 968 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1027
Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 6007
+ E + L E + + +K Q+ +Q++ M +++ L E P G S + Q+ + + L+
Sbjct: 1028 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1087
Query: 6008 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 6067
+I +Q +N + +++ +E A+P L++ L L + + + +++
Sbjct: 1088 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1143
Query: 6068 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6124
L+ L + Q+ + + +A+E + T L A+ K + Q
Sbjct: 1144 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1203
Query: 6125 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 6184
+L E V+A + V E L E + T + + L +L +L E+ H
Sbjct: 1204 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKTLEEVWACWH 1261
Query: 6185 DKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 6243
+ ++ + E + L T++ PG E E+ + L
Sbjct: 1262 ELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEVLDS 1300
Query: 6244 QKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 6303
++L+R +I I A+T D G +++++EL + +W LH
Sbjct: 1301 LENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWRELH 1347
Query: 6304 QEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSAVTS 6353
+E +QKLL+ ++ QE Q + ++ L+ K D Q+ + S
Sbjct: 1348 EEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 1407
Query: 6354 LLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLFVAT 6405
L + EE+ + G + I + QK VS + E+RL +
Sbjct: 1408 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESK 1467
Query: 6406 ALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-PENG 6448
+L E ET QE+ L K + E+ E++ Q +
Sbjct: 1468 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1527
Query: 6449 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 6508
+N +++ + L + L + V +R Q+++ L+ + ++ VL LA +
Sbjct: 1528 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1587
Query: 6509 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6568
++ A E + + + KE + + LK +V + L K + + +
Sbjct: 1588 KRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKETLVE 1642
Query: 6569 ELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEKMAG 6611
+ + ++ S S + L L +Y++ ++ AD L EK
Sbjct: 1643 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1702
Query: 6612 DQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6669
QK ++ K E+ + K + M RK++ + +EL +
Sbjct: 1703 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SELNHR 1755
Query: 6670 ASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--NEDR 6724
+A+ R K + L+ L++ ++ + LE +E+ I V L EE N+D
Sbjct: 1756 FAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 1808
Query: 6725 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMS 6784
D + L + Q + + D+ KR I I L+++ N L + K
Sbjct: 1809 NEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1865
Query: 6785 KELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVRDHL 6839
+ H+ W +Y+ ++ DL+ L + +L + + + +EL+ ++ L
Sbjct: 1866 EISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEEL 1918
Query: 6840 NAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSRIDS 6886
NA ++ + + + + S Q RL T+R E + +
Sbjct: 1919 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1978
Query: 6887 QWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6943
+ L ++ +P+ + E H Q A+ EV ++ + + ED K
Sbjct: 1979 EDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQEESL 2030
Query: 6944 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 7003
K I + LQ+ G +IDI + T + LQ S+ VE + E L ++ W
Sbjct: 2031 KNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLDFQW 2077
Query: 7004 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQNAL 7061
+ + + ++ + +E W + +++ W E+ L+ Q + A + L
Sbjct: 2078 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 2137
Query: 7062 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7121
K +L+D I ++ V + G +IQ + +SI+ L L W + +
Sbjct: 2138 K---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 2194
Query: 7122 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 7181
K L+ + S + ++ +L EA +++ L G + ++ +++ ++ L ++L
Sbjct: 2195 KKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELP 2253
Query: 7182 KQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQSSK 7235
++ L++ +L P + L N LK+ N++W L E+ E K
Sbjct: 2254 LRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIK 2313
Query: 7236 ALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ--DCN 7287
L QL ++ +D +Q S ++ Q + N+ + D+ + E+A + D
Sbjct: 2314 DLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQPDVE 2372
Query: 7288 DLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AASAIQ 7323
++L KG K+ L +L + K Q++ A AS Q
Sbjct: 2373 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2432
Query: 7324 SDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 7381
+ L ++Q + E A+ K + +SL V F ++ L W+ +++++ Q
Sbjct: 2433 TVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2491
Query: 7382 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQNLN 7434
DL I E + + K M P L+ L L +++E + R++ +
Sbjct: 2492 -VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2550
Query: 7435 RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ 7494
W + R +L L +LE E + L Q KL G Y Q+
Sbjct: 2551 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2610
Query: 7495 RAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7552
+ E Q RQ + + + +LL DD + ++ ++ W+ + +R
Sbjct: 2611 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2670
Query: 7553 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE- 7611
+R ++ R Q++ EK WL E + + ++ R L D KE
Sbjct: 2671 EREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGVKEL 2726
Query: 7612 -KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLE 7662
K + QG Y E +++L S + +A LQ L + KW +
Sbjct: 2727 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2786
Query: 7663 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQMRC 7714
+ L W++ + + L L+ +LS+ P ++H R
Sbjct: 2787 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2846
Query: 7715 KELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELLQRQ 7760
+ + V T + ++ L + L A +++ +L ++ E + +
Sbjct: 2847 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2906
Query: 7761 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEK 7817
WE+L + +++I E L E EL L Q E GD+LI+ + +
Sbjct: 2907 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2966
Query: 7818 LK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 7875
L+ K + EIA +EN + + +L + + L +N RW+ L +
Sbjct: 2967 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVED 3025
Query: 7876 RVKKLKE 7882
RV++L E
Sbjct: 3026 RVRQLHE 3032
Score = 176 bits (446), Expect = 9e-43
Identities = 468/2732 (17%), Positives = 1059/2732 (38%), Gaps = 408/2732 (14%)
Query: 1244 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1302
S E+ + E+ E + D + E + L HQ + I Q+ G
Sbjct: 349 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 400
Query: 1303 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1355
G L + E++ L S + L S E+Q R+ + L+ + E N + + +
Sbjct: 401 TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 459
Query: 1356 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1409
+T E L LE L +++Q K + E V+ +L V E+S G
Sbjct: 460 EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 514
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
L++Q K + ++ + E+ ++ + KW S W++EKE +
Sbjct: 515 DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 574
Query: 1470 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527
N + T+ +M S K+ + + + LE++ QS + + + K
Sbjct: 575 NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 626
Query: 1528 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
+ + E L A+C + + QK E++ +I Q+V+ + L T
Sbjct: 627 SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 669
Query: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1646
+T +E++++ T R+ + +E Q K+R
Sbjct: 670 QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 704
Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1706
Q +++ + +RL+ +++ +W+ R EA SPE I + + A++ E
Sbjct: 705 QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 761
Query: 1707 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761
+A + KL S ++ + + +K EQL+ RW + Q++++R+N+L+
Sbjct: 762 --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 819
Query: 1762 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
+++A + QQ +++ + W+K+ + T SE + + Q+ + KD +
Sbjct: 820 YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 874
Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1874
+ +++ L+ L G+ L F++ V+ R+ L + + L
Sbjct: 875 LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 932
Query: 1875 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1930
+ ++S I ++Q T + ++ + +++E+ L + +L+ L +
Sbjct: 933 PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 992
Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1990
+ + K SE ++ +++ G +++ + L + + + Q+ + L
Sbjct: 993 TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1052
Query: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2049
K + +++ +E + L+++L+ L ++ + + L + + ++I + +
Sbjct: 1053 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1112
Query: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2109
FA ++ E+ L WD + ++ + G ++ Q S + + + A
Sbjct: 1113 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1172
Query: 2110 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168
+ R K ++L+ A + + AK + K+ + T ++++ + +K
Sbjct: 1173 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1229
Query: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228
++E+ + + +L L + W ++LS ++ W N ++ + +
Sbjct: 1230 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1285
Query: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2288
N E + E ++N E+ +++ L + + +L E +
Sbjct: 1286 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1345
Query: 2289 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347
V + L + + QS Q EK ++ I T +++ L ++ A + +
Sbjct: 1346 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1400
Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
E Q QS+++S + +L + K H+ E+ R ++ + + + + K + + +
Sbjct: 1401 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1457
Query: 2408 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
+F + +QE + K ++ + +V++++L+ N+ S+S+ +S+++ V
Sbjct: 1458 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1515
Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
+ G+ + + + E++T + + + KQ L+ C + L
Sbjct: 1516 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1575
Query: 2528 NLWI----HEMEERFNTENL----------GESKQHIPEKK----NEVHKVEMFLGELLA 2569
W+ E+ +R E + G++ Q EK+ + +V L +L
Sbjct: 1576 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1635
Query: 2570 ARESL--DKLS------------------------------------------QRGQLLS 2585
+E+L DKLS Q LL
Sbjct: 1636 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1695
Query: 2586 EEGHGAGQEGRLCSQLLTSHQNLLR----MTKEKLRSCQVALQEH--EALEEALQSMWFW 2639
E Q+ + L + N +R T+++ + +H + +E + +
Sbjct: 1696 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1755
Query: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAI-------------- 2685
AI R+ ++++ K+ LE+ S IQ LL E E++ + +
Sbjct: 1756 FAAISHRIKTGKASIPLKE-LEQFNSDIQK-LLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1813
Query: 2686 GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES--------VISQWND 2737
G ++ L+ + QR+ + ++ ++ + +A L S + QW
Sbjct: 1814 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1873
Query: 2738 YVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFV------LLDHLQSILSEAEDHTRALH 2791
Y + + L + ++ +++K+ +P+ K K + + L ++ +AE +
Sbjct: 1874 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1933
Query: 2792 RLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2851
+ + ++ + + + F I TV +E M + E + + Y+ + +
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTY- 1992
Query: 2852 FTDWLHSAK-----EELHRWSDM-SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAP 2905
T+ H ++ E+L D+ + D K+ +K + DS + + R+ + S
Sbjct: 1993 LTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 2052
Query: 2906 EVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
Q+ T + + L W++ V++M Q G+ +
Sbjct: 2053 AALQSATPVERVKLQEALSQLDFQWEK---------------VNKMYKDRQ---GRFDRS 2094
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG------QEILDALQKAEPRTEDL 3019
+ +F +K + Q LT E +I E W +E+ D + + + L
Sbjct: 2095 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 2154
Query: 3020 KSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQAS---KGCQNKEQILQQRFRKAFR 3074
+ E+ + S D S K+ L + +C Q S K + ++ IL + F++
Sbjct: 2155 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSE-FQRDLN 2213
Query: 3075 DFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG--ELLS 3132
+F WL A + + P ++ L++++ + E Q L + G L+S
Sbjct: 2214 EFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2272
Query: 3133 TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALE-------NLKIQMKDFEVSAEPI 3185
++ E+ ++ K+ W L +K+ +E L+ +++D E +
Sbjct: 2273 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2332
Query: 3186 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3245
WLS + +Y+ P + +Q + +P + + K Q L++ +
Sbjct: 2333 LLWLSPIRNQL-----EIYNQP-NQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKP 2386
Query: 3246 ASKSFRHRVSQLSSQYLALSNLTKEKVSR-------LDRIVAEHNQ-------------- 3284
A++ + ++ LSS++ A++ L +E ++ L I A Q
Sbjct: 2387 ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 2446
Query: 3285 --------------------FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
F+ EL DW++ ++ S D ++ +K +
Sbjct: 2447 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 2506
Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIRCKSQ 3383
A + +++ Q++ ++T +++ TS + T I +++ +++ W + + Q
Sbjct: 2507 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 2566
Query: 3384 LEGAL---SKWTSYQDGVRQFSG--------W------MDSMEANLNESERQHAELRDKT 3426
L L ++W ++ Q G W +D+++ + E+++ +LR
Sbjct: 2567 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 2626
Query: 3427 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3486
T + A L ++L S +T +V H +T +++ +R+I +R E
Sbjct: 2627 TNVDVANDLALKLLRDYSADDTRKV-------HMIT----ENINASWRSIHKRVSEREAA 2675
Query: 3487 SEKLVRLHQEYQRDLKAFEVWLGQEQ-----------------------EKLDQYSVLEG 3523
E+ RL Q++ DL+ F WL + + E + Q+ L+G
Sbjct: 2676 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2735
Query: 3524 DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQ 3583
+ H +L E Q +L S+ + + V+ R L+++ W +
Sbjct: 2736 EIEAHTDVYHNLDE------NSQKILRSLEGSDDAVL-------LQRRLDNMNFKWSELR 2782
Query: 3584 HRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS---------PRTRRQS--NRA 3632
+ R+ ++ + + Q++ WL+ ++++S P ++Q+ +RA
Sbjct: 2783 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA 2842
Query: 3633 TK-EIQLHQ--MKKWHEEVTAYRDE-----VEEVGARAQEILDE---SHVNSRMGCQATQ 3681
K E++ + + E V + E +E++ +E+ E +V + QA +
Sbjct: 2843 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE 2902
Query: 3682 LTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
+ + ++ L L + + ++E ++ L+E + +
Sbjct: 2903 VNTEWEKLNLHSADWQRKIDETLERLQELQEA 2934
Score = 167 bits (423), Expect = 4e-40
Identities = 525/3002 (17%), Positives = 1145/3002 (38%), Gaps = 438/3002 (14%)
Query: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4195
E+ +L A+ LQ +++E + ++ + ++ L + Q V I++
Sbjct: 342 EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 399
Query: 4196 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4249
KL++ EE+ +++N LN +W + +QSN + + Q+ ++ +D +
Sbjct: 400 GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 459
Query: 4250 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
E + + + E LE LK+ +Q+ K EDL+ Q+ + +L
Sbjct: 460 E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 503
Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4369
+V +++S + LE E+L V+ R+ + W E++
Sbjct: 504 HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 544
Query: 4370 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4429
LL D L L +Q L + + + + + + + + LS
Sbjct: 545 -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 591
Query: 4430 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4488
Q +DL ++++ + K S K Q L++ + S Q+ E + ++ D+
Sbjct: 592 LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 646
Query: 4489 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4548
V K K+ ++ T Q +T E + VT +E+ V +EL
Sbjct: 647 VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 697
Query: 4549 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4607
+ +++ + RK D + W+ +++ ++ PE + + K
Sbjct: 698 PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 757
Query: 4608 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
I + E L R+ Q ++ + N SE+LN+ +F +++ +
Sbjct: 758 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 817
Query: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4722
I + L ++TT + + L+ Q S+ PT A++ L + C+ ++
Sbjct: 818 LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 871
Query: 4723 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4777
++GL ++ L + + GQ P D T + + + E+ + + DT
Sbjct: 872 LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 931
Query: 4778 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4831
+ E M QQ E +L Q V + + E++L +L SLQ+
Sbjct: 932 PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 987
Query: 4832 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4891
L ++ +++++ K + + + +G K L+S + E + E +M + Q
Sbjct: 988 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1047
Query: 4892 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4951
+ W+ V L + + +++++++ ++ ++Q+ +N+++ ++
Sbjct: 1048 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1107
Query: 4952 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 5011
+A+ ++ LE L EL+ + + + R+ L + + ++W+
Sbjct: 1108 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1167
Query: 5012 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 5068
A+E + + ++ +E K+ E +++ ++ L +++ +I P +
Sbjct: 1168 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1225
Query: 5069 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5128
E L++++ +L Q + + L+ A WH+ E+ + +N+ E F
Sbjct: 1226 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1280
Query: 5129 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5183
L T + E++SE V++S + E+ +Q+ T ++
Sbjct: 1281 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1334
Query: 5184 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5243
+ T RW L A ++K+LE ++ + E + + +L A+K
Sbjct: 1335 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1394
Query: 5244 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5303
A++ ++ Q L +S L++ G+E Q + + D
Sbjct: 1395 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAA--QRVLSQIDV 1438
Query: 5304 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE--------IDA 5355
+ V +L ++ E ++ K + E K +L P +E + +
Sbjct: 1439 AQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEVKMHL--PALETKSVEQEVVQS 1492
Query: 5356 QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQD 5415
QL L + + +E + + ++ T P EL ++ + L +++
Sbjct: 1493 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---NELGA 1549
Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG---- 5471
K+ E +Q +LSR+++K +LT+ A TD + ++ + + LD
Sbjct: 1550 KVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1605
Query: 5472 --CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAENRLSK 5521
K +E K + + G+ LGK KL+ L+ I +AE L+
Sbjct: 1606 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNL 1665
Query: 5522 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5581
L + H+E +++ ++ I KWI +A L + Q +E + + L E +I
Sbjct: 1666 LLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELNDIRP 1721
Query: 5582 ELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
++++ ++ L + +C + + Q++EL + IK ++ K++++F
Sbjct: 1722 KVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFN 1779
Query: 5639 AELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV------QAV 5689
++++KL LE Q L + + ++ + LL ++L+ ++ + +
Sbjct: 1780 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1839
Query: 5690 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH 5749
++ Q L+ + + L + +++A + H Q + + E+++
Sbjct: 1840 KIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1894
Query: 5750 L-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL--NSKC 5802
L ++ I+ RE++ K + ++ QA+ + A ++ Q Q++ +
Sbjct: 1895 LPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWREIES 1953
Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE 5862
K + + + TV E E + TED+ E+ PS + + + T +S
Sbjct: 1954 KFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVSQALL 2004
Query: 5863 ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ 5922
E +++P C ++I S+ R+ IH +A+
Sbjct: 2005 E-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKKTAAL 2055
Query: 5923 EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI 5982
+ P L L WE + + ++Q ++E+ +++ ++ + +
Sbjct: 2056 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2115
Query: 5983 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSESCEAD 6036
E L ++ P + EH + LQD I + Q ++ EE++ +S + D
Sbjct: 2116 EQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 2169
Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
+ LQ L L R + + S +++ LEE Q+ L ++ + +E
Sbjct: 2170 AS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDLNEFV 2216
Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
WL L P KE ++ +L + ++ E+ + L +L+ +L+
Sbjct: 2217 LWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2275
Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSPGVQE 6214
+ +E ++L KL++ +++ RAL +KQ ++ ++ + E ++ Q +
Sbjct: 2276 -SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLL 2334
Query: 6215 WLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6271
WL+ R + Q Q +E E + ++ + + S+G+ +
Sbjct: 2335 WLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY------------ 2382
Query: 6272 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 6331
EKP A ++ K E L E+ +LLQ + ++ +
Sbjct: 2383 KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD--------- 2418
Query: 6332 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6391
L G+ G PTQ + VT + A ++ S S+ LE +
Sbjct: 2419 LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADFNRAW 2471
Query: 6392 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6451
T L D L + + +Q ++ D+++++E + K K
Sbjct: 2472 TELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD--------- 2511
Query: 6452 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6511
+ QR Q++E + N +N TS + + II
Sbjct: 2512 --------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII---- 2542
Query: 6512 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6571
++IE IQ D ++E LQ + + E+ K
Sbjct: 2543 --------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK--------- 2572
Query: 6572 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQLLDK 6629
Q L K + E+ L LE+ +E G + K+ E +QL
Sbjct: 2573 --------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQLAKD 2621
Query: 6630 HKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE 6689
+++ ++ L L R + +K + A ++ KR +R LE E
Sbjct: 2622 LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE---E 2678
Query: 6690 TWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLKSSLN 6740
T L + +L + L + + + ++++ ++RL+ + + +Q L+ +
Sbjct: 2679 THRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 2738
Query: 6741 EYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLETILKH 6796
+ + + ++ +++L S+ SD L+ +L+ + W K LE
Sbjct: 2739 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 2798
Query: 6797 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6856
W R +L+ WLQ D L + + + V+ + F +E+ + +
Sbjct: 2799 WKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI 2854
Query: 6857 SSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDLLTNI 6895
S L T L + ++ T LR + ++++W L +
Sbjct: 2855 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 2914
Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
Q K+ + +++L ++ + + L + + K + ++ ++L+K K
Sbjct: 2915 ADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 2972
Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015
+ +I + V VN Q+++ ++ + + + +N W++LQ V ++++
Sbjct: 2973 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVR 3028
Query: 7016 LL 7017
L
Sbjct: 3029 QL 3030
Score = 162 bits (409), Expect = 2e-38
Identities = 468/2591 (18%), Positives = 974/2591 (37%), Gaps = 351/2591 (13%)
Query: 600 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-------NQSENAKKDFFRNLPH 652
E +S S L E N DRY + + +WL AE L N E K F + +
Sbjct: 318 EDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGY 377
Query: 653 WIQQHTAMNDAGNFL--------IETCDEMVSRDLKQQLLLLNGRW---RELFMEVKQYA 701
+ GN L E ++++Q+ LLN RW R ME +
Sbjct: 378 MMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL 437
Query: 702 QADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQ-------DLEDIEQ 754
MD ++ + L+ K EPL ++K +Q DLE +
Sbjct: 438 HRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQV 497
Query: 755 RVPVMDAQYKIITKTAHLITKESPQEEGK---EMFATMSKLKE--------------QLT 797
RV + ++ +++ + +E+ K + +A + + E +LT
Sbjct: 498 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 557
Query: 798 KVKECYSPLLYESQQLLIPLEELE-KQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 856
+ + +S L E + + + K SL K+ + LE++ QS Q
Sbjct: 558 EEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQ 617
Query: 857 ELLACQENCKKT-----------------LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQR 899
+LL+ +N T + +EK + + + VT + QT +
Sbjct: 618 DLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQTTVME 675
Query: 900 QIADIHVAFQSMVKKTGDW--------KKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 951
+ + Q +VK + K+ + +S + K+ + EL + ++ L+
Sbjct: 676 TVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ 735
Query: 952 EKGDPEELLRRHTEFFSQLDQRVLNAF----------LKACDELTDILPEQ------EQQ 995
PE + R FS L ++V NA L+ L EQ
Sbjct: 736 S---PEFAIFRKEGNFSDLKEKV-NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD 791
Query: 996 GLQEAVRKLHKQWKD---LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQE 1052
+++A +L+ +W + L E L + + L +E+ T + K+ P
Sbjct: 792 SIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTT 851
Query: 1053 GSEKI-IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAA 1111
SE IK D+ RL ++ +L ++ G + L A
Sbjct: 852 PSEPTAIKSQLKICKDE------VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA 905
Query: 1112 IDSTYRKLMEDPDKWKD-------------YTSRFSEFSSWISTNETQLKGIKGEAIDTA 1158
+ ++++ D + Y S +W+ +ET+L + D
Sbjct: 906 FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYE 965
Query: 1159 NHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALV 1218
+ ++ +++ + ++ L +L + +K +++ + ++K E ++ +K L
Sbjct: 966 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1025
Query: 1219 TLLSE----VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENL---FEA 1271
+ L E +E+ ++ + + +K + E+ ++E+ + D+E L +
Sbjct: 1026 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV---DVFLKEEWPALGDSEILKKQLKQ 1082
Query: 1272 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ 1331
+LL+ Q + + Q+I + E R EL++L + D + + +
Sbjct: 1083 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKELNTQWDHMCQQVYAR 1140
Query: 1332 ERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1391
+ ++ L K + + + ++ Q + E +L EL++ E KR +
Sbjct: 1141 KEALKGGLEKTVSLQKDLSEMHEWMTQ---AEEEYLERDFEYKTPDELQKAVEEMKRAKE 1197
Query: 1392 IAVQAENLVKEASE------IPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1445
A Q E VK +E P ++ L+++ +++ + L L KT+E V
Sbjct: 1198 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1257
Query: 1446 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEE 1505
W S E + W+ E E +L E + +I + +E+ +
Sbjct: 1258 ACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE----EISEVLDSLENLMRHSEDNPN 1313
Query: 1506 EAQSFAQFVTTG--ESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1563
+ + AQ +T G I +L EL E A + + + Q+ E++L
Sbjct: 1314 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1373
Query: 1564 IQQSVSEFEDKLAVPI--------------KICSSATE---TYKVLQEHMDLCQALESLS 1606
IQ+S++ + +LA I KI S T + + +++H +A + +
Sbjct: 1374 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVL 1433
Query: 1607 SAITAFSASARKVVNRDSCVQEAAALQQQYED---ILRRAKERQTALENLLAHWQRLEKE 1663
S I + V + Q+ A +Q+ ++ IL K ALE + ++ +
Sbjct: 1434 SQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1493
Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
L+ + + S EM I R Q++Q Q E +
Sbjct: 1494 LNHCVNLYKSLSEVKSEVEMVIKTGR-------QIVQKKQTENPKELD------------ 1534
Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
+ V +KLH +L + + Q + K + + + E E W+
Sbjct: 1535 ------ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE-------WLAA 1581
Query: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
EL S + M + A ++ + E++ + HL + +G A L +
Sbjct: 1582 TDMELTKRSAVEGMPSNL-----DSEVAWGKATQKEIEKQKVHLKSITEVGEA--LKTVL 1634
Query: 1844 GKAEDCFQLFEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVE-ATNSMNKNE 1901
GK E L E+ ++ +A+ S E+L + Q V+ T + + +
Sbjct: 1635 GKKE---TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQAD 1691
Query: 1902 SDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVER 1961
+ L E + Q L+ L+ I K + +Q + A C
Sbjct: 1692 TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD-----STRDQAANLMANRGDHC----- 1741
Query: 1962 IQNLLGTKQSEAD-ALAVLKKAFQDQKEEL-LKSIEDIEERTDKERLKEPTRQALQQRLR 2019
+ L+ + SE + A + + K + LK +E +D ++L EP +QQ +
Sbjct: 1742 -RKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF--NSDIQKLLEPLEAEIQQGVN 1798
Query: 2020 V----FNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRL 2073
+ FN +D +E + L + + Q+ D E+ + L+ + K L
Sbjct: 1799 LKEEDFN--KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1856
Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2133
+ + + + +Y+ + K L++ + + +D+ +K + + K
Sbjct: 1857 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1916
Query: 2134 KMNYKQKDLDNFTSKGKHLLSELKKIHSS----------------DFSLVKTDMESTVDK 2177
++N ++ + + G + E +I S +F+ + T E T+
Sbjct: 1917 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETM-- 1974
Query: 2178 WLDVSEKLEENMDRL-RVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEEL 2236
+ ++E + + + L+ V E+E N P + + ++ + EE
Sbjct: 1975 -MVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN--APDLC--AKDFEDLFKQEES 2029
Query: 2237 LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAK 2296
LK + ++ + R++ +HSK K TP + ++ L Q +++ ++ K
Sbjct: 2030 LKNIKDSLQQSSGRIDIIHSK----KTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2085
Query: 2297 GTLKDFTAQSTQVEKFINDI---TTWFTKVEESLMNCAQNETCEALK---KVKDIQKELQ 2350
F + +F DI W T+ E+ L E E K +K++Q +
Sbjct: 2086 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2145
Query: 2351 SQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL-IKKHEAVSQLCS-KTQASLQESLE 2408
+Q+ + + + ++ + L + L ++ E QL K + Q+++
Sbjct: 2146 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2205
Query: 2409 KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQ 2468
F + EF W A A + G + L+ KL ++ +++ + Q L + +
Sbjct: 2206 SEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNE 2264
Query: 2469 EGQTLY--AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
G + A +S + ++ ++ + N Q +K +AL + E+ +
Sbjct: 2265 TGGPVLVSAPISPEEQDKLENKLKQTN-------LQWIKVSRALPEKQGEIEA------- 2310
Query: 2527 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
++LG+ ++ + + + +++ + ++L + E ++ +Q G +
Sbjct: 2311 ------------QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 2358
Query: 2587 EGHGAGQEGRL-CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2642
E A Q + ++L+ Q+L + T+ R + E +A+ LQ + +A
Sbjct: 2359 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL----RA 2414
Query: 2643 IQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQ 2700
Q LA +T+G+ T + ++ + ++ K KL M ++ AL N+
Sbjct: 2415 KQPDLAPGLTTIGASPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2472
Query: 2701 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2760
+ W ++ + +Q + + N+ + ++ Q +E
Sbjct: 2473 ELTD---------WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE---------- 2513
Query: 2761 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2820
Q +P L+E +L++ S E T R+ E ++ Q
Sbjct: 2514 QRRPQLEELITAAQNLKNKTSNQEARTIITDRI---------------------ERIQNQ 2552
Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
++++ + + +++ E++KD +L+A E L A+ +L W + A QKK+
Sbjct: 2553 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 2612
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
++ K+L + + LA ++ ++ +A +H + + A W+ V +
Sbjct: 2613 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 2672
Query: 2941 QSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVE 2997
++ LE L+ Q L ++F +A L +A E + +L+ ++ LLE +E+++
Sbjct: 2673 EAALEETHRLLQQFPLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMK 2728
Query: 2998 CWHKGQEILDA 3008
W Q ++A
Sbjct: 2729 QWQDLQGEIEA 2739
Score = 159 bits (402), Expect = 1e-37
Identities = 533/2914 (18%), Positives = 1109/2914 (38%), Gaps = 456/2914 (15%)
Query: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3120
+ ++ R++ A + WL++A+ T +I ++ V + ++ + Q +
Sbjct: 328 ESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGR 387
Query: 3121 LNMMLSKGELL--STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDF 3178
+ +L G L + L++++ +Q ++ W+ +K+S L + + +++
Sbjct: 388 VGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQ 447
Query: 3179 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3236
++ + + DWL+KTE+ + DL +R+ Q+ + + E++ + ++N L
Sbjct: 448 KL--KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 505
Query: 3237 AQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEK-------VSRLDRIVAEHNQFSL 3287
+ E G A+ + ++ L ++ + T+++ + + R+ E FS
Sbjct: 506 VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 565
Query: 3288 GIKELQDWMT--------DAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE--KEIQM 3337
+ E +D + D ML S K+ L+ + + L S+KQ+ ++
Sbjct: 566 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 625
Query: 3338 KMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA--GIRCKSQLEGALSKWTSYQ 3395
K + + E+ L N + +Q+ +S + ++ + + + +E + T Q
Sbjct: 626 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQ 685
Query: 3396 DGVRQFSGWMDSMEANLNESERQHAELRDKT----TMLGKAKLLNEEVL----------- 3440
V+ + +E+R + T L +E VL
Sbjct: 686 ILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 745
Query: 3441 -SYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQER-------AKEAVTKSEKLVR 3492
++S L E + E + +LQD +A+ E+ A SE+L
Sbjct: 746 GNFSDLKEKVNAIEREKAEKF---RKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNS 802
Query: 3493 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3552
E+ + L WL + + Y+ L+ TT + ++Q + S
Sbjct: 803 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQ-QLEQMTTTAENWLKIQPTTPSEPTAIKSQ 861
Query: 3553 LHTREDVIP--SGI-PQAEDRALESL-----------------------RQDWQAYQHRL 3586
L +D + SG+ PQ E ++S+ +Q + Q R
Sbjct: 862 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQARE 921
Query: 3587 SETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHE 3646
E +T F+ + +R E + W++ +E K+S ++ E +L +++
Sbjct: 922 KELQTIFDTLP-PMRYQET-MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 979
Query: 3647 EVTAYRDEVEEVGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3704
+ + + + +E+ + S ++ + + ++ R++ L Q++E + LEE++
Sbjct: 980 SLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQM 1039
Query: 3705 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3764
L + ++ + + W K + D+ ++ K+LK +L+ D++ L
Sbjct: 1040 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG--DSEILKKQLKQCRLLVSDIQTIQPSL 1097
Query: 3765 KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV--RKEHMT--LEKGLHLAKE 3820
S E G++ E A RL E+ + Q + V RKE + LEK + L K+
Sbjct: 1098 NSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKD 1157
Query: 3821 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880
S+ + +TQ EY E + P E + + + K ++ E VK + E
Sbjct: 1158 LSEMHEWMTQAEEEYLERDFEYKTPD----ELQKAVEEMKRAKEEAQQKEAKVKLLTESV 1213
Query: 3881 EALLELVQDVT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKW 3937
+++ V LK +++ L ++YQ LC+ +LE + S L++ KW
Sbjct: 1214 NSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKW 1273
Query: 3938 LLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI-GQCAD 3996
L ++ +L + + + E I++ L + +M ED N +++ TL G D
Sbjct: 1274 LNEVEFKLKTTENIPGGA-EEISEVLDSLENLMRHS---EDNPNQIRILAQTLTDGGVMD 1329
Query: 3997 HL----------------------QAKLKQNVHAHLQGTKD----------------SYS 4018
L Q L+Q++ + + K +Y
Sbjct: 1330 ELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI 1389
Query: 4019 AICSTAQRMYQSLE-------------HELQKHVSRQDTLQQCQAWLSAVQPDLEPSP-- 4063
A A +M Q + E++KH ++ Q+ + + Q L+
Sbjct: 1390 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1449
Query: 4064 ----QPPLSRAEAIKQVK--------HFRAL------QEQARTYLDLLCSMCDLSNASVK 4105
Q P + + +++ K H AL QE ++ L+ C S + VK
Sbjct: 1450 FRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH-CVNLYKSLSEVK 1508
Query: 4106 TTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQDADQQLQNMKR--RH 4160
+ + + +T + I QK Q +N + E + LK +EL + + QQL+ + R
Sbjct: 1509 SEVEMVIKTGRQIVQKK-QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1567
Query: 4161 SELELNIAQNMV----------SQVKDFVKKLQSKQA-----------------SVNTII 4193
E+N+ + S V+ L S+ A S+ +
Sbjct: 1568 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1627
Query: 4194 EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDLQRTRDYHDCMNVVE 4250
E + + K+E+ +++ LN W+ + ++ NL L+ ++ ++ D
Sbjct: 1628 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD------ 1681
Query: 4251 VFLEKFTTEWDNLA-RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
+ K+ + D L S+ + + LK+L L + + ++ +DQ ++ +
Sbjct: 1682 -HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1740
Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIA 4368
++LV+ Q S L R+ + IK K + + LE+ N + E +E +Q N+
Sbjct: 1741 CRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK 1800
Query: 4369 EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALS 4428
E D +++ D+ EL + L+ I D +R+ I+
Sbjct: 1801 EE-------DFNKDMNEDNEGTVKELLQRGDNLQQRITDE---------RKREEIKIKQQ 1844
Query: 4429 DAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD 4488
Q+ N L DL QRRK KAL Q+ QA ++ + + + LP+
Sbjct: 1845 LLQTKHNALKDLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD---IEKKLASLPEP 1898
Query: 4489 -----VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVY 4543
+ + + + + L + + GL G + E T+ + S+ +++ + +
Sbjct: 1899 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 1958
Query: 4544 DSVLQKCSHRLQE-----------LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLM 4592
+ H ++E LE + V + E + L+ ++ P++
Sbjct: 1959 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL-CA 2017
Query: 4593 NESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQF 4652
+ +L Q +NI + + + + L S V+ L E L+ L Q+
Sbjct: 2018 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQW 2077
Query: 4653 NVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEE---- 4708
+ + KD+ + ++ + + I++ Q L+E E QFLR +++P + +
Sbjct: 2078 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQIPENWEHAKYKWY 2136
Query: 4709 ALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQ 4768
LQDG V L +E+ Q+ T +K+ L + + +Q
Sbjct: 2137 LKELQDGIGQRQTVVRTLNATGEEIIQQSS---KTDASILQEKLGSLNLRWQEVCKQLSD 2193
Query: 4769 RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDS 4828
R LE+ + E ++ + L+ N ++P E G Q
Sbjct: 2194 RKKRLEEQKNILSEFQRDLNEFVLWLEEAD------NIASIPLEP---------GKEQQL 2238
Query: 4829 GIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID 4888
L++V + +E+L PL + Q+ G + + E + E+++ Q+
Sbjct: 2239 KEKLEQVKLLVEEL-----PLR-QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL 2292
Query: 4889 FQTEMSRSLDWLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHK 4947
++SR+L + ++A++ L+ L+D++E++ + + +++ L I N +
Sbjct: 2293 QWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ- 2351
Query: 4948 EKEKFTKAKELISADLEHSLAELSELDGDIQE---ALRTRQATLTEIYSQCQRYYQVFQA 5004
E D+QE A++ +Q + EI S+ Q Y+
Sbjct: 2352 ------------------------EGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE--- 2384
Query: 5005 ANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLI 5063
+ A + +K +E S+E + L+EL + L P +
Sbjct: 2385 ---------------------KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 2423
Query: 5064 KPTGKEDLE------QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5117
G + Q V + E ++ S +++ D+ +A E+ + +
Sbjct: 2424 TTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA-----DFNRAWTELTDWL 2478
Query: 5118 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-KTGNDA 5176
+ ++ + ++ + E + + KA + + ++ L A L+ KT N
Sbjct: 2479 SLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 2537
Query: 5177 SKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPG 5236
++ ++ + + +W ++ Q++ + L + + + T + ++A +++ Q + KL
Sbjct: 2538 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 2597
Query: 5237 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
+ + + +L Q Q+ + + L +L+D +A ++ +
Sbjct: 2598 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA----DDTRKVHM 2653
Query: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQ 5356
IT E + + + + + + +RE ++ET L +
Sbjct: 2654 IT----------ENINASWRSIHKRVSEREAA----------LEETHRLLQ----QFPLD 2689
Query: 5357 LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQD 5415
LE+ LTEA ++ +++ L E + +K + Q QD
Sbjct: 2690 LEKFLAWLTEAETTANVLQDATRKER-----------------LLEDSKGVKELMKQWQD 2732
Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSK 5475
E+E L QK+ + L + D +L LD N K
Sbjct: 2733 LQGEIEAHTDVYHNLDENSQKILRSL---------------EGSDDAVLLQRRLDNMNFK 2777
Query: 5476 LMEL---DAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEY 5532
EL ++ LE + K L + +L + Q +R + + +++
Sbjct: 2778 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSRQAPIGGDFPAVQKQ 2836
Query: 5533 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEA--MTEKL 5590
N++ + ++ + + T+ + + L +E +E+ E A +T L
Sbjct: 2837 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2896
Query: 5591 QYLTSVYCT--EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKK--- 5643
+ T EK++ A+ R+ +E + RLQ LQ+A D+K +AE+ K
Sbjct: 2897 RKQAEEVNTEWEKLNLHSADWQRKIDETLE----RLQELQEATDELDLKLRQAEVIKGSW 2952
Query: 5644 ----------LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSEMESLKPKVQAVQLC 5692
LQ LE+ +A G ++ LKE +SH L ++ +L +QL
Sbjct: 2953 QPVGDLLIDSLQDHLEKVKALR-----GEIAPLKENVSHVNDLARQLTTL-----GIQLS 3002
Query: 5693 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5726
L ED+ L A+ E+ R H A
Sbjct: 3003 PYNLSTLEDLNTRWKLLQVAV---EDRVRQLHEA 3033
Score = 157 bits (397), Expect = 4e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 5520 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 5577
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 324 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 379
Query: 5578 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 5636
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 380 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 436
Query: 5637 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 5695
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 437 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 491
Query: 5696 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 5755
L ++ V L H + + E + A+ E+++K L
Sbjct: 492 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 533
Query: 5756 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 5802
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 534 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 593
Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 5856
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 594 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 645
Query: 5857 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5916
L E+S ++IS PS T + + + + Q + P
Sbjct: 646 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 699
Query: 5917 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 5976
Q + + + +L SW T + + + ++ + D +
Sbjct: 700 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 752
Query: 5977 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 6036
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 753 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 791
Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 792 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 835
Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 836 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 895
Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 6216
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 896 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 939
Query: 6217 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 6264
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 940 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 999
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 6295
+ + K +E+ +K S+ E+QM
Sbjct: 1000 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1059
Query: 6296 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6351
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 1060 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1119
Query: 6352 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 6406
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1120 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1179
Query: 6407 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 6462
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1180 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1236
Query: 6463 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 6506
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1237 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1296
Query: 6507 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 6564
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1297 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1340
Query: 6565 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 6624
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1341 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1396
Query: 6625 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 6684
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1397 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1450
Query: 6685 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 6744
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1451 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1509
Query: 6745 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 6801
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1510 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1569
Query: 6802 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 6857
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1570 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1621
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1622 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1681
Query: 6918 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 6977
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1682 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1733
Query: 6978 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 7036
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1734 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1787
Query: 7037 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 7087
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1788 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1847
Query: 7088 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 7142
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1848 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1907
Query: 7143 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 7197
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1908 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1962
Query: 7198 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 7256
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1963 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2011
Query: 7257 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 7316
A D A +D + L +KDSL + + + A
Sbjct: 2012 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2053
Query: 7317 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 7369
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 2054 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2113
Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 7427
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 2114 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2173
Query: 7428 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7483
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2174 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2230
Query: 7484 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 7540
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2231 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2290
Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2291 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2350
Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 7660
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2351 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2408
Query: 7661 LEEQKKKLAFL--------------------------------------------LKDWE 7676
L+E + K L L D+
Sbjct: 2409 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2468
Query: 7677 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7733
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2469 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2528
Query: 7734 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7793
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2529 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2585
Query: 7794 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 7849
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2586 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2645
Query: 7850 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 7909
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2646 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2703
Query: 7910 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 7962
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2704 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2762
Query: 7963 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 8022
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2763 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2820
Query: 8023 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 8063
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2821 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2880
Query: 8064 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8122
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2881 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2936
Query: 8123 WLTEMDLQLTNIE 8135
E+DL+L E
Sbjct: 2937 ---ELDLKLRQAE 2946
Score = 142 bits (359), Expect = 1e-32
Identities = 456/2427 (18%), Positives = 928/2427 (38%), Gaps = 370/2427 (15%)
Query: 3631 RATKE--IQLHQMKKWHEEVT-AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQ 3687
+ TKE QLH + +++T + E + ++ + + S +
Sbjct: 251 KVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFP 310
Query: 3688 ALLLQVLEQIKF----LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743
+ L+ E F +E E+ +L+ +++L W S + + V+ V
Sbjct: 311 SQHLEAPEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVK- 368
Query: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3803
+ T E + D+ + + + G + + + E E E+ + M L
Sbjct: 369 -DQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWEC 425
Query: 3804 VRKEHMTLEKGLH--LAKEFSDKCKALTQWIAEYQEILHVPEEPKM--ELYEKKAQLSKY 3859
+R M + LH L + K K L W+ + +E EE + +L + K Q+ ++
Sbjct: 426 LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 485
Query: 3860 KSLQQTVLSHEPSVKSVR-----------EKGEALLE----------------------L 3886
K LQ+ + + V S+ + A LE L
Sbjct: 486 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 545
Query: 3887 VQDVTLK-DKIDQLQSDYQDLCSIGKEHVFSLEAK-VKDHEDYNSELQ-------EVEKW 3937
+QD+ LK ++ + Q + S ++ V + KD + S LQ ++EK
Sbjct: 546 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 604
Query: 3938 LLQMSGRLVA--PDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCA 3995
Q G+L + DLL T +++TQ+ +A ++ A D L K I Q
Sbjct: 605 KKQSMGKLYSLKQDLLSTLKNKSVTQKT---EAWLDNFARCWDNLVQKLEKSTAQISQAV 661
Query: 3996 DHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK---HVSRQDTLQ------ 4046
Q L Q ++ + + + Q + + + EL RQ T+
Sbjct: 662 TTTQPSLTQTT------VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 715
Query: 4047 ------QCQAWLSAVQPDLEPSPQPPLSRAE-----------AIKQVK--HFRALQEQAR 4087
+ +W++ + L+ SP+ + R E AI++ K FR LQ+ +R
Sbjct: 716 LDVDITELHSWITRSEAVLQ-SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASR 774
Query: 4088 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ---GWEEIKHLKSELWI 4144
+ L+ M + A I+Q + + + ++ L W E ++ +
Sbjct: 775 SAQALVEQMVNEG-----VNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYN 829
Query: 4145 YLQDADQQLQNMK-----RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL 4199
LQ +Q + + + E ++ + KD V +L Q + + + L
Sbjct: 830 QLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL 889
Query: 4200 TKKEESPEHKEI------NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4253
+K + P + NH + D+ Q+ LQ D Y + M+ + ++
Sbjct: 890 KEKGQGPMFLDADFVAFTNHFKQVFSDV--QAREKELQTIFDTLPPMRYQETMSAIRTWV 947
Query: 4254 EKFTTEWD--NLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDK 4311
++ T+ L+ +D E L L+ L +LQE++ + L ++M + +
Sbjct: 948 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1007
Query: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL 4371
+ + +E RW +L + Q + +L +Q+ Q L +W E + E
Sbjct: 1008 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1067
Query: 4372 KQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQ 4431
++ + L + S+++ Q L S+ + ++ + ++ L +
Sbjct: 1068 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1127
Query: 4432 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4491
+ + + V R++ L L + + + + Q E + + R+ PD++ K
Sbjct: 1128 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQK 1187
Query: 4492 QVKTCKSA-------QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYD 4544
V+ K A +A +K V + AQ + +E ++E L+ L + Y
Sbjct: 1188 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE-------LETLTTNYQ 1240
Query: 4545 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAK 4604
+ + + + + LE+ +KA WL + + N+ + E+ L
Sbjct: 1241 WLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDS 1300
Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY 4664
+N++ S + N + L +T D + E +N FN ++
Sbjct: 1301 LENLMRHSEDNPNQIRILAQT---------LTDGGVMDELINEELETFN-------SRWR 1344
Query: 4665 KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVA 4724
++ E + R++ L+E + QS E E ++E+L+ D A A
Sbjct: 1345 ELHEEAVRRQK---LLEQSIQSAQETEKSL---------HLIQESLTFIDKQLA-----A 1387
Query: 4725 GLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHE 4784
+ + VD +E Q Q D H ++L ++H
Sbjct: 1388 YIADKVDAAQMPQE-----AQKIQSDLTSHEISL-------------------EEMKKHN 1423
Query: 4785 KMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAG---SLQDSGIVLKRVTIHLED 4841
+ + +R L + Q K+ + ++ K +++ A LQ+S ++L V +HL
Sbjct: 1424 QGKEAAQRVLSQIDVAQKKLQDVSM----KFRLFQKPANFEQRLQESKMILDEVKMHL-- 1477
Query: 4842 LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECE------SRMVQSIDFQTEMSR 4895
P L+ + E + +QS L ++ E +E E ++VQ QTE +
Sbjct: 1478 --PALETKSVE--QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK--KQTENPK 1531
Query: 4896 SLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA 4955
LD RV A L L+ ++ K+ +++++ L++ + KE
Sbjct: 1532 ELD--ERVTA-------LKLHYNELG---AKVTERKQQLEKCLKLSRKM---RKEMNVLT 1576
Query: 4956 KELISADLEHSLAELSELDG---DIQEALRTRQATLTEIYSQ---CQRYYQVFQAANDWL 5009
+ L + D+E L + S ++G ++ + +AT EI Q + +V +A L
Sbjct: 1577 EWLAATDME--LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 1634
Query: 5010 EDAQELLQ-----LAGNGLDVES-AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 5063
+ L++ L N + V S AEE L +E+ + F N++ + + D L+
Sbjct: 1635 GKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1694
Query: 5064 ------KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY-QKAREEVIEL 5116
KP KED+ +++ + EL R DS D A D+ +K E I
Sbjct: 1695 DESEKKKPQQKEDVLKRLKA-ELNDIRPKVDSTR--DQAANLMANRGDHCRKLVEPQISE 1751
Query: 5117 MNDTEKKLSEFSLLKTSSS----HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKT 5172
+N +S +KT + E E+ S+ + L+ + + ++ V L+E+ K
Sbjct: 1752 LNHRFAAISH--RIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE--DFNKD 1807
Query: 5173 GNDASKATLSRSM---TTVWQRWT--RLRAVAQDQEKILE------------------DA 5209
N+ ++ T+ + + QR T R R + ++++L+ +
Sbjct: 1808 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 1867
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
+W + + + +D ++ KL S E + ++ + EL++++ L
Sbjct: 1868 SHQWYQYKRQADDLLKCLDDIEKKL-ASLPEPRDERKIKEIDR-------ELQKKKEELN 1919
Query: 5270 MLRQQTLSMLQDGAA----PTPGEEPPLMQEITA--MQDRCLNMQE--KVKTNGKLVKQE 5321
+R+Q + +DGAA PT + +EI + Q R LN + V+ +V E
Sbjct: 1920 AVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE 1979
Query: 5322 LKDREM------VETQINSVKCWVQETKEYLGNPTI---EIDAQLEELQILLTEATNHRQ 5372
E+ T+I V + E ++ L P + + + ++ + L + +Q
Sbjct: 1980 DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQ 2039
Query: 5373 NIEKMAEEQKEKYLGLYTILPSE-LSLQLAEVALDL---KIRDQIQDKIKEVEQSKATSQ 5428
+ ++ +K L + P E + LQ A LD K+ +D+ ++S +
Sbjct: 2040 SSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWR 2099
Query: 5429 ELSRQIQKLAKDLTTILTKLKAKT---DNVVQAKTDQKVLGEELDGCNSK---LMELDAA 5482
I K+ T + KT +N AK + L E DG + + L+A
Sbjct: 2100 RFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKY-KWYLKELQDGIGQRQTVVRTLNAT 2157
Query: 5483 VQKFLEQNGQL-GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILK 5541
++ ++Q+ + L +K+G L Q+ +Q +R +L + + L E+ L +
Sbjct: 2158 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2217
Query: 5542 WIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEK-----LQYLTSV 5596
W+E+A +A + QL+E+ + L+EE L+ + E + S
Sbjct: 2218 WLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISP 2277
Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE------- 5649
+K+ ++ + + ++ + + + ++ KD+ + E +L+ L+ L
Sbjct: 2278 EEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2337
Query: 5650 ------------------QAQATLTSPEVGRLSLKEQLSHRQHLLSE----------MES 5681
Q T + + + ++E LS QHL E +E
Sbjct: 2338 PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED 2397
Query: 5682 LKPKVQAVQLCQSALRIPE-DVVASLPLCHAA----LRLQEEASRLQHTAIQQCNIMQAA 5736
L + +AV LR + D+ L A+ + L + + TAI + + +
Sbjct: 2398 LSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSL 2457
Query: 5737 VVQ---YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQE 5793
+++ + + L + + I+ + V +++++ I + + Q ++ +
Sbjct: 2458 MLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP 2517
Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTE 5820
Q+ L + + L K + +T+
Sbjct: 2518 QLEELITAAQNLKNKTSNQEARTIITD 2544
Score = 134 bits (337), Expect = 4e-30
Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)
Query: 7330 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 7389
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 311 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 367
Query: 7390 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 7441
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 368 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 427
Query: 7442 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 7499
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 428 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 487
Query: 7500 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7555
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 488 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 543
Query: 7556 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7615
++ + +WQR E WL E D V
Sbjct: 544 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 582
Query: 7616 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7675
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 583 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 639
Query: 7676 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7735
+C + LEK ++ AV + LTQ +++
Sbjct: 640 ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 674
Query: 7736 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7795
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 675 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 719
Query: 7796 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 7847
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 720 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 779
Query: 7848 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 7895
E +E I+ ++N RW L++ R+ L+ ++A +QQL++ +
Sbjct: 780 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 839
Query: 7896 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7955
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 840 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 890
Query: 7956 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 8015
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 891 EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 947
Query: 8016 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 8075
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 948 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1007
Query: 8076 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 8134
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 1008 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1067
Query: 8135 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 8193
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 1068 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1127
Query: 8194 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 8248
CQ+V+ R E L + + L D ++ + + E+ D +
Sbjct: 1128 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1179
Query: 8249 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8308
+ L ++ + R++ + A V L+ + S +++A P E
Sbjct: 1180 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1226
Query: 8309 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 8354
+ + + Y L+G LE S + + K L++ F+++ TEN
Sbjct: 1227 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1286
Query: 8355 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 8414
I P G E E S +DS LE+ ++ E++ P + + +
Sbjct: 1287 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1324
Query: 8415 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8462
GV+D RW L +A+ ++ ++Q++Q Q+ TE+
Sbjct: 1325 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1370
Query: 8463 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 8522
L +Q D Q K+ Q + +K + +L S E + + K+ ++
Sbjct: 1371 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1427
Query: 8523 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 8579
RV S ++ + LQD M+ + F + ++ + E+ +D K + +
Sbjct: 1428 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1480
Query: 8580 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 8638
++ +++ E++Q + + L E + V + Q++ + + E E+V +
Sbjct: 1481 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1540
Query: 8639 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 8679
L +V+ ++LEK L +S + L+ W +A +++
Sbjct: 1541 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1585
Score = 119 bits (298), Expect = 1e-25
Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)
Query: 521 SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 571
S +++W+ + + S+ QL +E S EQ Y + EM
Sbjct: 941 SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1000
Query: 572 KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 631
KA + + E +W+ LS ++ LEE ++ + N + +L+ W+ +
Sbjct: 1001 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1058
Query: 632 AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 678
+ L + SE KK R L IQ ++N+ G + + +
Sbjct: 1059 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1118
Query: 679 LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 734
L+ +L LN +W + +V YA+ + + K + V+L +E H+ ++ E
Sbjct: 1119 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1172
Query: 735 LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
LE F ++ +++++ ++ +A+ K++T++ + + ++P
Sbjct: 1173 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1225
Query: 790 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
LK++L + Y L LEE+ L K N+ + +E
Sbjct: 1226 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1278
Query: 850 LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 908
FK K T I G++ + + + +L N+++H + Q +I +
Sbjct: 1279 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1324
Query: 909 QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968
++ + + + +ET + ++ E +K+L ++ ++ + E+ L E +
Sbjct: 1325 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1379
Query: 969 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1024
+D++ L A++ D++ QE Q +Q + L + K QG+ + +I
Sbjct: 1380 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1436
Query: 1025 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1083
DV + + ++ + +L + + E+ ++E ++ D+ HL + +E+
Sbjct: 1437 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1487
Query: 1084 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1131
V+ + V + +L E+++ ++ + K E+P + + +
Sbjct: 1488 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1542
Query: 1132 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1188
++E + ++ + QL+ K + E+ E + +TKR + + S L
Sbjct: 1543 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1599
Query: 1189 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1245
+V +++ E +KQ L ++ +AL T+L + E ++ + + I V +
Sbjct: 1600 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1659
Query: 1246 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1292
EE ++ E Q+ E T+ + +A LL ++K KR+ A+ D+
Sbjct: 1660 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1719
Query: 1293 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1352
+ ++ + L + RKL + E R ++ R +T K ++
Sbjct: 1720 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1770
Query: 1353 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1411
++ L Q S ++ L E L +E++Q + + + +N + G
Sbjct: 1771 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1825
Query: 1412 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1462
+Q + + K IK+Q+ + + +D+++ K +W + + L +
Sbjct: 1826 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1885
Query: 1463 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1514
+ EK+L +L + +I +I +Q+ + +L+++ GL E+ + A Q
Sbjct: 1886 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1943
Query: 1515 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1568
+ I++K Q RR +RE + E L + + + Q++
Sbjct: 1944 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2003
Query: 1569 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1621
E E L P + +K + ++ +L+ S I TA SA V
Sbjct: 2004 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2062
Query: 1622 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1681
R + + L Q+E + + K+RQ + + W+R ++ F WL E
Sbjct: 2063 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2122
Query: 1682 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1741
++ + + K + L + LQ+ + + + L E + +SK D +++ L
Sbjct: 2123 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2179
Query: 1742 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1801
L+ RW+++ + ++ R L+ +F L F +W L E + I + +
Sbjct: 2180 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2235
Query: 1802 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1852
+ K+ +V+ EL QG L +L G E+ L+ K +
Sbjct: 2236 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2293
Query: 1853 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1910
+ + S+ + +Q + + + + Q L + QL + + + +N+ ++ +
Sbjct: 2294 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2352
Query: 1911 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1967
D + A+++ ++ ILSK Q+ K + Q + + L E + + LL
Sbjct: 2353 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2410
Query: 1968 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2024
+++ LA + + + + + T +L+ P+ L+ L FN+
Sbjct: 2411 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2470
Query: 2025 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2084
EL WL Q+ + +++ +IN + + T + + + + Q L
Sbjct: 2471 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2519
Query: 2085 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2144
+L+ QNLK+ S + A ++I R E +N+ + Q+ L N
Sbjct: 2520 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2562
Query: 2145 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2204
+ L+E+ K +ST +WL+ E+ E+ + + R L W +
Sbjct: 2563 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2603
Query: 2205 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2253
T D I+ Q+A+++ +N+D N L A +LL+++ ++ K + E
Sbjct: 2604 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2661
Query: 2254 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2310
+H +V++ + + ET LQ DL + L E E L+D +T+ E
Sbjct: 2662 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2714
Query: 2311 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
+ + D E +K+ +D+Q E+++ + EN + R
Sbjct: 2715 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2758
Query: 2371 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2422
S + L R + + K + + ++ L+ S + K S+QE W
Sbjct: 2759 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2818
Query: 2423 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2468
+G A K++ + L+ K + + L++V L+ + Q
Sbjct: 2819 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2878
Query: 2469 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
E + L Q V+ +++Q + N E++ ++ + + L ++ +L
Sbjct: 2879 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2938
Query: 2528 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
+L + + E + + + +G+ I ++ + KV+ GE+ +E++ ++ + L+
Sbjct: 2939 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 2996
Query: 2587 EG 2588
G
Sbjct: 2997 LG 2998
Score = 114 bits (286), Expect = 3e-24
Identities = 347/2017 (17%), Positives = 774/2017 (38%), Gaps = 287/2017 (14%)
Query: 3927 YNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMK 3986
Y + L+EV WLL L A + ++ +E + Q H+ M ++ + R+ N+
Sbjct: 336 YQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQL 394
Query: 3987 GDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA---ICSTAQRMYQSLEHELQKHVSRQD 4043
G LIG KL ++ +Q + ++ A QS H + + Q
Sbjct: 395 GSKLIGT------GKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK 448
Query: 4044 TLQQCQAWLSAVQPDLEPSPQPPLSR--AEAIKQVKHFRALQEQARTYLDLLCSMCDLSN 4101
L++ WL+ + + PL + +QV+ + LQE DL +++
Sbjct: 449 -LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE------DLEQEQVRVNS 501
Query: 4102 ASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHS 4161
+ D + Q + L W I + W+ LQD + Q +
Sbjct: 502 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTE--- 558
Query: 4162 ELELNIAQNMVSQVKDFVKKLQSKQ-ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLD 4220
E + +S+ +D V K+ + N ++ + KL + E K
Sbjct: 559 --EQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKK----------- 605
Query: 4221 LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4280
+QS ++DL T E +L+ F WDNL + +STA +A+
Sbjct: 606 --KQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 663
Query: 4281 LALALQERKY--AIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQV 4338
+L + + + ++Q +++H +EL ++R ++ I++++ V
Sbjct: 664 TQPSLTQTTVMETVTTVTTREQILVKHAQ---EELPPPPPQ--KKRQITVDSEIRKRLDV 718
Query: 4339 SVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398
+T EL W +EA+ QSP + + S+L+ K
Sbjct: 719 DIT-------------ELHSWITR-----SEAVLQSP-----EFAIFRKEGNFSDLKEKV 755
Query: 4399 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN-------KA 4451
++ + R + D + + ++++ +++ + +D + Q + LN +
Sbjct: 756 NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN-----ADSIKQASEQLNSRWIEFCQL 810
Query: 4452 LSEKTQFLMA---VFQATSQIQQHERKIMFREHICLL-------PDDVSKQVKTCKSAQA 4501
LSE+ +L + +Q+QQ E+ E+ + P + Q+K CK
Sbjct: 811 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 870
Query: 4502 SLKTYQNEVTGLWAQGRELMKEVT----------------EQEKSEVLGKLQELQSVYDS 4545
L Q ++ L Q L ++ +Q S+V + +ELQ+++D+
Sbjct: 871 RLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 930
Query: 4546 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI-VTFPEINLMNESSELHTQLAK 4604
+ ++E W++Q++ ++ P++++ + + +L +
Sbjct: 931 L----------------PPMRYQETMSAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGE 973
Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKF 4663
Q + E ++ L L T + + +E+ Y SE + ++ + + +
Sbjct: 974 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHC 1032
Query: 4664 YKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDE 4722
K++E + ++ + I+ + ++E++ FL+ + P L E L Q CR ++ +
Sbjct: 1033 QKLEEQMNKLRKIQNHIQTLKKWMAEVDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSD 1089
Query: 4723 VAGLGEAVDELNQKKEGFRSTGQP--------------WQPDKMLHLVTLYHR---LKRQ 4765
+ + +++ +N+ + ++ +P Q D M V Y R LK
Sbjct: 1090 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV--YARKEALKGG 1147
Query: 4766 TEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSL 4825
E+ VSL +D + + HE M Q E L+ ++ + K +E A E++K A
Sbjct: 1148 LEKTVSLQKDLS---EMHEWMTQAEEEYLE--RDFEYKTPDELQKAVEEMKRAKEEA--- 1199
Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
Q +K +T + + P+A E + ++++ + L + + E
Sbjct: 1200 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1259
Query: 4886 SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQE---EIRKIQIHQEEVQSSLRIMN 4942
+ + + ++ WL V+ +L + ++I E + + H E+ + +RI
Sbjct: 1260 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI-- 1317
Query: 4943 ALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVF 5002
L +L + +D I E L T + E++ + R ++
Sbjct: 1318 --------------------LAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLL 1357
Query: 5003 QAANDWLEDAQELLQLAGNGLDV--ESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 5060
+ + ++ ++ L L L + + ++ + +L S +L+
Sbjct: 1358 EQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLE 1417
Query: 5061 PLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR---EEVIELM 5117
+ K ++ Q+V S +Q+ +D + L Q+ Q+++ +EV +
Sbjct: 1418 EMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHL 1477
Query: 5118 NDTEKKLSEFSLLKTSSSH--EAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5175
E K E ++++ +H + LSE K+ V +V +IV ++ + E
Sbjct: 1478 PALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE----- 1532
Query: 5176 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP 5235
L +T + + L A ++++ LE + ++ TE + +L
Sbjct: 1533 -----LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1587
Query: 5236 GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ 5295
SA + + L + + + E+E+Q+ L ++++ + + G++ L++
Sbjct: 1588 KRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL-----KSITEVGEALKTVLGKKETLVE 1642
Query: 5296 E-ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEID 5354
+ ++ + + + + + L+ + K E + ++ + W+ + L +
Sbjct: 1643 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1702
Query: 5355 AQLEE-LQILLTEATNHRQNIEKMAEEQKEKYLG-------LYTILPSELSLQLAEVALD 5406
Q E+ L+ L E + R ++ ++ L SEL+ + A ++
Sbjct: 1703 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHR 1762
Query: 5407 LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ--KV 5464
+K + +KE+EQ + D+ +L L+A+ V K + K
Sbjct: 1763 IKT-GKASIPLKELEQFNS--------------DIQKLLEPLEAEIQQGVNLKEEDFNKD 1807
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQ 5524
+ E+ +G +L++ +Q+ + + + K+ +L + ++ ++ K
Sbjct: 1808 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQ--QLLQTKHNALKDLRSQRRKKAL 1865
Query: 5525 AASHL-EEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSE 5582
SH +Y + +LK ++ K LA S + R++ + KEID E
Sbjct: 1866 EISHQWYQYKRQADDLLKCLDDIEKKLA-------SLPEPRDE--------RKIKEIDRE 1910
Query: 5583 LEAMTEKLQYLT----------SVYCTEKMSQQVAELGRETEE---------LRQMIKIR 5623
L+ E+L + + E Q+++ RE E Q+ +R
Sbjct: 1911 LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVR 1970
Query: 5624 LQNLQDAAKDM--------KKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHL 5675
+ + +DM + E+ + AL + + L +P++ ++ + L
Sbjct: 1971 EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESL 2030
Query: 5676 LSEMESLKP---KVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI 5732
+ +SL+ ++ + ++A V + L A +L + ++ +
Sbjct: 2031 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2090
Query: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS--------NIQELQAQISRHEEL 5784
+V ++ ++ ++K Q + A + + + + ++ELQ I + + +
Sbjct: 2091 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTV 2150
Query: 5785 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 5821
+ + E+I +SK ++ K ++ L EV
Sbjct: 2151 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 2187
Score = 108 bits (269), Expect = 3e-22
Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)
Query: 7255 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 7303
++ ED++ + L+++ N D A +EV +W+ D L+ G + + + F
Sbjct: 314 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 373
Query: 7304 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
HE LG +L ++ + +Q L+ L A ++
Sbjct: 374 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 433
Query: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
Q++L ++D + + L+ L W+ + EE + + + +E+LK Q+ +
Sbjct: 434 QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 485
Query: 7404 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 7450
+ DL+ R+N L + + + D+ ++++ L W+ I T +R+
Sbjct: 486 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 545
Query: 7451 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 7510
LQ LL+ Q E+ + +L + E + + ++ Q EM S Q
Sbjct: 546 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 594
Query: 7511 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 7570
L + D LE+ + ++LK LLS + Q+ +D+ R W
Sbjct: 595 LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 645
Query: 7571 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 7628
+ +KL K ++S + + L Q + V +E++ ++ +
Sbjct: 646 LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 701
Query: 7629 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
K+ ++ DS L ++ E+ W + S + + + F + E +D EK
Sbjct: 702 KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 754
Query: 7689 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 7748
+ +++ ++ ++L++A S +L++ ++ ++AD I
Sbjct: 755 VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 794
Query: 7749 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7808
+E+ L +W E C LS ERLN W + L Q+E + +
Sbjct: 795 QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 843
Query: 7809 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 7859
L I+ + ++ I ++ +L + ++ + +S A + ++
Sbjct: 844 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 903
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 7917
+ ++ + + AR K+L+ + + + MS++RTW+ E++L+ P +
Sbjct: 904 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 962
Query: 7918 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 7977
+ E ++++L E Q LQ +++ +G L + + A Q ++
Sbjct: 963 DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1018
Query: 7978 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 8032
RW+ + + +E K+EE +K + + W+ E A S
Sbjct: 1019 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 1074
Query: 8033 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8092
+ K++LK+ + L +N+ +++ E + A L+ + E N +WD++
Sbjct: 1075 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1133
Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 8150
++V + LK + + + + W+T+ + + + E+ + ++Q ++++K
Sbjct: 1134 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1193
Query: 8151 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 8210
++E K++ + +I ++ P+ +++EL+ L Q + R
Sbjct: 1194 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1245
Query: 8211 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 8270
L+ + LE+ A WH+ LLS +N L+ + ++
Sbjct: 1246 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1283
Query: 8271 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 8328
+ P + I D +L R E + R L +G + +
Sbjct: 1284 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1343
Query: 8329 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 8388
L + + K L+ S Q+TE + + +D Y+ + + +
Sbjct: 1344 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1403
Query: 8389 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 8447
+++ L E SL + + V+ + ++ AQ +++ MK L QK F
Sbjct: 1404 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1461
Query: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
L L + + L L+ S + + ++ Q+ L K++ K+ + +
Sbjct: 1462 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1519
Query: 8508 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
+ Q E+ ++L +R++ + ++ + + + E + L+ L + + + L L
Sbjct: 1520 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1579
Query: 8567 ENID---RRKNEIVPIDSNLDAEI 8587
D +++ + + SNLD+E+
Sbjct: 1580 AATDMELTKRSAVEGMPSNLDSEV 1603
Score = 65.9 bits (159), Expect = 2e-09
Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)
Query: 8304 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 8358
PS+ E +DK F + V L +ALE + L A D + Q I +++
Sbjct: 310 PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 369
Query: 8359 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 8411
+ T ++GYM L + ++ +L KL ++EE + +NL ++
Sbjct: 370 QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 421
Query: 8412 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8471
RWE L+ ++ K+ + + L Q N L + WL TEE +++ L
Sbjct: 422 --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 471
Query: 8472 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 8530
D++ ++ Q+++ K LQ+ ++ + + S+ ++ + + L+++L + R
Sbjct: 472 GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 531
Query: 8531 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 8590
W +C E+ LLQD L++ Q E L + N+I E+L
Sbjct: 532 WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 591
Query: 8591 HHKQLMQIKHELLESQLRVASLQDMSCQLL 8620
K L +K +L + + + L + LL
Sbjct: 592 LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 620
Score = 49.3 bits (116), Expect = 2e-04
Identities = 143/807 (17%), Positives = 297/807 (36%), Gaps = 150/807 (18%)
Query: 134 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 193
Q++ L LP Q + + V P P ++ K++ K+ L+W++ +
Sbjct: 2244 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2300
Query: 194 ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 248
KQ IE +KD G+ + ++ + L + N+ N E F + ET
Sbjct: 2301 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2360
Query: 249 ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYP-------DIHNASTDGQEDDEIL-- 299
E+ V +PD + I++ K P + + S++ + + +L
Sbjct: 2361 EIA---------VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 2411
Query: 300 ---------PGFPSFANS--------VQNFKREDRVIFK--------------------- 321
PG + S Q ++ I K
Sbjct: 2412 LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 2471
Query: 322 -EMKVWIEQFERDLTRAQMVESNLQDKYQSF---KHFRVQYEMKRKQIEHLIQPLHR-DG 376
E+ W+ ++ + +++ +L+D + K E +R Q+E LI
Sbjct: 2472 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 2531
Query: 377 KLSLDQAL---------VKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA--- 424
K S +A ++ WD V L + QL++ L WL E A
Sbjct: 2532 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST----QWLEAKEEAEQV 2587
Query: 425 ---LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQ 481
R ++ + T + IQ+K+ + K L ++ R + + + + D
Sbjct: 2588 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL----RQWQTNVDVANDLALKLLRDY 2643
Query: 482 LEDMAERFHFVS-----STSELHLMKME---FLELKYRLLSLLVLAESKLKSWIIKYGRR 533
D + H ++ S +H E LE +RLL L K +W+ +
Sbjct: 2644 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2703
Query: 534 ESVEQLLQNYVSFIENSKF--------------FEQYEVTYQILKQTAEMYVKADGSVEE 579
+V Q +E+SK E + Y L + ++ +++ ++
Sbjct: 2704 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2763
Query: 580 AENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQS 639
A + + ++ +W L + ++RS LE W R ++ L WL+ + L++
Sbjct: 2764 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2823
Query: 640 ENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGR----WRELFM 695
DF +Q+ ++ A ++T + ++ L+ + L + +L+
Sbjct: 2824 APIGGDF-----PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2878
Query: 696 EVKQY---AQADEMDRMKKEYTDCVVT----LSAFATEAHKKLSEPLEVSFMNVKLLIQD 748
E ++ +A + R+ ++ + V T L+ + + +K+ E LE +Q+
Sbjct: 2879 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE--------RLQE 2930
Query: 749 LEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLY 808
L++ + + Q ++I K S Q G + ++ E++ ++ +PL
Sbjct: 2931 LQEATDELDLKLRQAEVI--------KGSWQPVGDLLIDSLQDHLEKVKALRGEIAPL-- 2980
Query: 809 ESQQLLIPLEELEKQMTSFYDSLGKIN 835
++ + + +L +Q+T+ L N
Sbjct: 2981 --KENVSHVNDLARQLTTLGIQLSPYN 3005
Score = 35.4 bits (80), Expect = 2.5
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 5939 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5998
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2902 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2961
Query: 5999 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2962 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3016
Query: 6055 STIRMKASGKRQLLEEKLND 6074
+++ + + L E D
Sbjct: 3017 KLLQVAVEDRVRQLHEAHRD 3036
>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
Length = 3681
Score = 315 bits (807), Expect = 1e-84
Identities = 628/3214 (19%), Positives = 1227/3214 (38%), Gaps = 521/3214 (16%)
Query: 23 DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
DE+E VQK+TFTKW+N+ +K + ++LF D++DG +LL LLE L+GQKLP E+G
Sbjct: 7 DEREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
Query: 83 MKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNL 142
R+HA+ N+ AL+ L+ + LVNI STDI DG + LGL+W IIL++Q++ + N+
Sbjct: 66 --RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNI 123
Query: 143 PQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKD 202
+ Q N++K LL WV+ + + V +
Sbjct: 124 -----------------------------MAGLQQTNSEKILLSWVRQSTRNYPQVNVIN 154
Query: 203 FGKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPRLLDPEDV 261
F SW G+A +++IH+ RP+L D +V +S + LE AF IA +LGI +LLDPEDV
Sbjct: 155 FTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDV 214
Query: 262 DVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFK 321
D PD+KSI+ Y+ + P S + ++ E+LP P +E+
Sbjct: 215 DTTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------KEEHFQLH 265
Query: 322 EMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLD 381
+ +Q L + S+ + +++S+ + + Y H
Sbjct: 266 HQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL------- 318
Query: 382 QALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANT 441
+A +S+ S L + + LD+ A L + +WL AE L+ + +
Sbjct: 319 EAPEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI----SNDVEV 370
Query: 442 IQRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFVSSTSE-L 498
++ + H+ + + AH+ I + ++ + + D+ ++ E+ + ++S E L
Sbjct: 371 VKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL 430
Query: 499 HLMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVEQLLQNYV 544
+ ME +R+L L + K L W+ K R E +++ +Q +
Sbjct: 431 RVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHK 490
Query: 545 SFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWRNLSVEVR 602
E+ EQ +V L + ++ G A E +K + + +W N+
Sbjct: 491 VLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTE 544
Query: 603 SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMND 662
+L++++ W R AWL + E +N+ HT
Sbjct: 545 DRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI-----------------HTTGFK 587
Query: 663 AGNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCV 717
N ++ + ++ + DL KQ + L ++L +K + + + + C
Sbjct: 588 DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARC- 646
Query: 718 VTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKES 777
L + LE S + + + + VM+ + T+ L+
Sbjct: 647 ----------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ 696
Query: 778 -----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSL 831
P + K S+++++L + E +S + L P + ++ +F D
Sbjct: 697 EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLK 756
Query: 832 GKINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTLTLIEKGS 876
K+N I + + + AL +Q E + A ++ + + + S
Sbjct: 757 EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLS 816
Query: 877 QSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK----KF 932
+ + +N++ ++Q + Q+ + + T +++ ++ K +
Sbjct: 817 ERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRL 876
Query: 933 EESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKACDELTDIL 989
+ ++E+ L+I L+EKG L F+ ++V + A K + D L
Sbjct: 877 SGLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 935
Query: 990 PEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTELDR-ETK 1047
P Q A+R W Q E + L + D E +E+ EL ++
Sbjct: 936 PPMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGELQALQSS 984
Query: 1048 LMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKE 1107
L Q+ + S K P + K EE+ K+
Sbjct: 985 LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI-----------------EGRWKK 1027
Query: 1108 LRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV-KRA 1166
L + + +KL E +K + + W++ + LK E E+ K+
Sbjct: 1028 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGDSEILKKQ 1083
Query: 1167 VEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEK 1226
+++ R V+ + ++ L + E + + + + + ++L + K L T + +
Sbjct: 1084 LKQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1139
Query: 1227 MLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF----------------- 1269
+ KE +K LE+ +S K++ E E + E +
Sbjct: 1140 QV------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAV 1193
Query: 1270 -EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSR 1328
E ++ QQK ++ V IAQA P E L+K TL
Sbjct: 1194 EEMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL------- 1239
Query: 1329 ERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR 1388
T +W N + + L + + LS+ LE + L + + K
Sbjct: 1240 --------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNEVEFKLKT 1287
Query: 1389 TESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW 1448
TE+I AE E SE+ +N L + ++ Q++ L TL + E++ +
Sbjct: 1288 TENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMDELINEEL 1340
Query: 1449 DHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQ 1508
+ F S + L ++K L S+ + + I+ ++ I+ +L++ + + +A
Sbjct: 1341 ETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA 1400
Query: 1509 SFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEENLR---K 1563
Q E+ +I++ LT EE+++H Q E +L + QK +++ +
Sbjct: 1401 QMPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFR 1455
Query: 1564 IQQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQALESLSSAI 1609
+ Q + FE +L +K+ A ET V QE ++L ++L + S +
Sbjct: 1456 LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEV 1515
Query: 1610 TAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKE 1663
+ R++V N + AL+ Y ++ + ER+ LE L +++ KE
Sbjct: 1516 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1575
Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
++ WL + + + + ++ E+ +A Q E+ Q + ++ E+L
Sbjct: 1576 MNVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL 1634
Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
+V K + +++ L L+ W + + +N L + FD+ + + WI
Sbjct: 1635 KTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ 1693
Query: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
+ L + + + L R K AE+ + ++ S + A +L+
Sbjct: 1694 ADTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA-----------NLMA 1739
Query: 1844 GKAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQLRQTVEA 1893
+ + C +L E + R A+SH L E Q ++ + +L L E
Sbjct: 1740 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLE--AEI 1797
Query: 1894 TNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATAD 1953
+N E D KD+N+ N ++ D + +I +R +
Sbjct: 1798 QQGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKREEIKIKQQ 1848
Query: 1954 QLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQA 2013
L + +++L ++ +A ++ ++ Q ++LLK ++DIE++ L EP +
Sbjct: 1849 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASLPEPRDE- 1905
Query: 2014 LQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPE-----VDREINRLEVTWD 2068
R +++ EL + EL ++ +A+ +++ A A E + + +E +
Sbjct: 1906 -----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFA 1960
Query: 2069 DTKRL----IHENQGQCCGLI--DLMREYQNLKSAVSKVLENASSVIVTRTTI------- 2115
+RL IH + + ++ D+ E + S + + S ++ +
Sbjct: 1961 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 2020
Query: 2116 -KDQEDLKWAFSKHETAKNKMNYKQKD---LDNFTSKGKHLLSELKKIHSSDFSLVKTDM 2171
KD EDL F + E+ KN + Q+ +D SK L + + +
Sbjct: 2021 AKDFEDL---FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 2077
Query: 2172 ESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE-NISNLDNH 2230
+ +W V++ ++ R S+ W W + + I H
Sbjct: 2078 DF---QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEH 2134
Query: 2231 LRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL------ETPPDLQFIEADLMQK 2284
+ + LKE + + + + L++ ++ + + E L ++ ++
Sbjct: 2135 AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQ 2194
Query: 2285 LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE----SLMNCAQNETCEALK 2340
L K+ E K L +F ++ +N+ W + + L + + E L+
Sbjct: 2195 LSDRKKRLEEQKNILSEF-------QRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLE 2247
Query: 2341 KVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELES-LGRAMTGLIKKHEAVSQ 2394
+VK + +EL +Q + E +++ +LE+ L + IK A+ +
Sbjct: 2248 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 2307
Query: 2395 LCSKTQASLQE--SLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNI 2452
+ +A +++ LEK + ++ L + + + D+Q
Sbjct: 2308 KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQET 2364
Query: 2453 LDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQ- 2511
+V Q ++ + +GQ LY K ++ ++ + E++A + + L++ +A Q
Sbjct: 2365 EIAVQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQP 2421
Query: 2512 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL--- 2568
D A L + T+ + Q + K+ + K+EM +L
Sbjct: 2422 DLAPGLTTIGAS---------------PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP 2466
Query: 2569 -------AARESLDKLSQRGQLLSEEGHGAG--------------------QEGRLCSQL 2601
A E D LS Q++ + G Q +L
Sbjct: 2467 ALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEEL 2526
Query: 2602 LTSHQNLLRMTK------------EKLRSCQVALQEH-----EALEEALQSMWFWVKAIQ 2644
+T+ QNL T E++++ +QEH + L E L+ W++A +
Sbjct: 2527 ITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKE 2586
Query: 2645 DRLACAESTLG--------------SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQ 2690
+ AE LG + D ++K++++ + + + + +++A +
Sbjct: 2587 E----AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALK 2642
Query: 2691 ALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWME 2750
LR + + R + E + W I ++ LE + + W+
Sbjct: 2643 LLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT 2702
Query: 2751 SVD---------QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY 2801
+ + E L+ G+KE L+ Q + E E HT H L S+++
Sbjct: 2703 EAETTANVLQDATRKERLLEDSKGVKE---LMKQWQDLQGEIEAHTDVYHNLDENSQKIL 2759
Query: 2802 EKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL---------MYLDAVHEF 2852
E Q L D M ++RK ++ HL ++L ++ E
Sbjct: 2760 RSLEGSDDAVLLQRRL-----DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL-SLQEL 2813
Query: 2853 TDWLHSAKEELHRWSDMSGDSSATQKKLS---------KIKELIDSREIGASRLSRVE-- 2901
WL +EL R + + GD A QK+ K KE + + R+ E
Sbjct: 2814 LVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP 2873
Query: 2902 ------------SLAPEVK-QNTT---ASGCELMHTEMQALRADWKQWEDSVFQTQSCLE 2945
L PE + QN T E ++TE + L W+ + +T LE
Sbjct: 2874 LEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDET---LE 2930
Query: 2946 NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTW 2979
L QE +L+ L Q + +W
Sbjct: 2931 RL--------QELQEATDELDLKLRQAEVIKGSW 2956
Score = 215 bits (547), Expect = 2e-54
Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)
Query: 6732 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6791
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 770 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 820
Query: 6792 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6848
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 821 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 872
Query: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 873 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 931
Query: 6907 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6963
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 932 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 988
Query: 6964 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 7022
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 989 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1044
Query: 7023 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7081
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 1045 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1104
Query: 7082 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7141
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 1105 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1164
Query: 7142 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7201
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1165 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1224
Query: 7202 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7261
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1225 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1284
Query: 7262 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7321
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1285 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1334
Query: 7322 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1393
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7436
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1394 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1453
Query: 7437 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7496
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1454 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1499
Query: 7497 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7554
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1500 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1558
Query: 7555 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1559 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1616
Query: 7613 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7672
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1617 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1674
Query: 7673 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7723
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1675 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1729
Query: 7724 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7783
D L + + IS LN R + + H++ + I L E
Sbjct: 1730 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1780
Query: 7784 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7843
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1781 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1830
Query: 7844 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7902
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1831 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1890
Query: 7903 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7961
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1891 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1938
Query: 7962 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 8003
E IQ L +RWR I + RRL EET + +
Sbjct: 1939 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1993
Query: 8004 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 8057
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2049
Query: 8058 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 2050 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2109
Query: 8118 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 8176
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 2110 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2168
Query: 8177 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 8234
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2228
Query: 8235 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8291
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2287
Query: 8292 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 8338
L+ +SRALP E Q + + ++ L LE Q+ L
Sbjct: 2288 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2343
Query: 8339 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 8381
+ + F +Q+TE +++K P E+ + + + L + S
Sbjct: 2344 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2403
Query: 8382 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 8440
S +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK L M +L
Sbjct: 2404 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2462
Query: 8441 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 8498
+D N W L D L+Q+ + + + D++ I I K K + ++ R+
Sbjct: 2463 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2522
Query: 8499 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 8552
+ + + + ++E+R + DR+ ++ +WD V L+ R +L+D+
Sbjct: 2523 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2582
Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
+ E L ++ K +D+ +Q + Q+ +L + Q V
Sbjct: 2583 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2636
Query: 8613 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8661
D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2637 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2681
Score = 195 bits (496), Expect = 1e-48
Identities = 525/2901 (18%), Positives = 1111/2901 (38%), Gaps = 392/2901 (13%)
Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
+L + L ++ ++ W+ E+ + GE + K++ H E ++ +L
Sbjct: 329 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 386
Query: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2626
A + + + Q G L G + E + NLL E LR + Q H
Sbjct: 387 AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 442
Query: 2627 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2679
L + L+ + W+ ++R E D LE Q+Q +++ + E V
Sbjct: 443 RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 501
Query: 2680 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2739
++N SS ++ QL+ L + WA+I + L+ ++ +W
Sbjct: 502 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
Query: 2740 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2796
E + W+ + + G K++ +L LQ + ++ E +++ +L +
Sbjct: 562 EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 619
Query: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
++L +++S ++ + ++ ++K+E+ + + + +
Sbjct: 620 KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 665
Query: 2857 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916
+ + L + + M ++ T ++ +K + + R ++ E+++
Sbjct: 666 TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 725
Query: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976
EL H+ + A + E ++F+ + +L ++ E+E + + +L+ A AL+
Sbjct: 726 EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 784
Query: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
+ EG N D + +E L S+ E C+ + +
Sbjct: 785 EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 821
Query: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
+ +I YN L Q L+Q A + WL T P
Sbjct: 822 LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 858
Query: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3153
+ + + L+ ++ ++ Q ++ + + ++ KEK +G + A A
Sbjct: 859 PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 913
Query: 3154 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3209
+K S++ +E L+ + + ++ + I+ W+ S+T+ + + S Y++ +
Sbjct: 914 FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 973
Query: 3210 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3264
R E Q LQS L+E ++ + + +KA S+ ++ ++ ++ L
Sbjct: 974 RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1028
Query: 3265 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
S+ E +L+ + + + I+ L+ WM + L D +L + +
Sbjct: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1088
Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3384
L+S Q + + + G+ + PE ++ +L+ + W + K L
Sbjct: 1089 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1148
Query: 3385 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3427
+G L K S Q + + WM D ++ + E +R E + K
Sbjct: 1149 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1207
Query: 3428 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487
K KLL E V S + A + EL+ L Y+ + R
Sbjct: 1208 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1257
Query: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3547
E++ E L+ WL + + KL + G A L L+ L H +
Sbjct: 1258 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1317
Query: 3548 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY-------QHRLSETRTQFNNVVNKL 3600
+ + T D + + + LE+ W+ Q L ++ L
Sbjct: 1318 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1375
Query: 3601 RLMEQKFQQVDEWLKT-------AEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
L+++ +D+ L A + + QS+ + EI L +MKK ++ A +
Sbjct: 1376 HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1435
Query: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
+ ++ AQ+ L + + R+ + R Q + +L+++K +++ +
Sbjct: 1436 VLSQIDV-AQKKLQDVSMKFRLFQKPANFEQRLQESKM-ILDEVKMHLPALETKSVEQEV 1493
Query: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
+ S + + +K+ V ++++ V +KT G +
Sbjct: 1494 VQSQLNHCVNLYKSLSEVKSEVEMV--------IKT---------------------GRQ 1524
Query: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833
V+ + + L + + EL + V + LEK L L+++ + LT+W+A
Sbjct: 1525 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1584
Query: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVT 3891
L + ++++ K+ Q+ + + +KS+ E GEAL ++ ++
Sbjct: 1585 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1644
Query: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951
++DK+ L S++ + S +E + L K E ++ + + KW++Q A LL
Sbjct: 1645 VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ------ADTLL 1698
Query: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ-------AKLKQ 4004
+ S + Q+ K + E+ ++++ + + L+ DH + ++L
Sbjct: 1699 DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNH 1758
Query: 4005 NVHAHLQGTKDSYSAI--------CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ 4056
A K ++I S Q++ + LE E+Q+ V+ ++ + + +
Sbjct: 1759 RFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKE-----EDFNKDMN 1813
Query: 4057 PDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQ 4116
D E + + L R + ++Q R E+ R + + + + ++ KD++
Sbjct: 1814 EDNEGTVKELLQRGDNLQQ----RITDERKREEIKIKQQLLQTKHNAL----KDLR---- 1861
Query: 4117 TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVK 4176
Q+ +A ++ W + K +L L D +++L ++ E ++K
Sbjct: 1862 --SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE----------RKIK 1909
Query: 4177 DFVKKLQSKQASVNTIIEKVNKLTK------------------KEESPEHKEINHLNDQW 4218
+ ++LQ K+ +N + + L++ +E + + LN
Sbjct: 1910 EIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQ 1969
Query: 4219 LDLCRQSNNLCLQREEDLQ--------RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ R+ + + + L+ T H ++EV E+ D L D E
Sbjct: 1970 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV--EQLLNAPD-LCAKDFED 2026
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4330
E+LK + +LQ+ I+ + +K ++ ++ ++E S L+ +W ++
Sbjct: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2086
Query: 4331 LIK---RKIQVSVTNLEELNVVQSRFQELMEWAEE-----QQPNIAEALKQSPPPDMAQN 4382
+ K + SV + F + + AE+ Q P E K Q+
Sbjct: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2146
Query: 4383 LLMDHLAICSELEA--KQMLLKSLIKDADRVMADLG-LNER-QVIQKALSDAQSHVNCLS 4438
+ + L A ++++ +S DA + LG LN R Q + K LSD + +
Sbjct: 2147 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2206
Query: 4439 DLVGQRRKYLNKAL--SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4496
+++ + ++ LN+ + E+ + ++ + QQ + K+ E + LL +++ +
Sbjct: 2207 NILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL---EQVKLLVEELPLR---- 2259
Query: 4497 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE 4556
Q LK NE G + E EQ+K E KL++ + V + + E
Sbjct: 2260 ---QGILKQL-NETGGPVLVSAPISPE--EQDKLE--NKLKQTNLQWIKVSRALPEKQGE 2311
Query: 4557 LE---KNLVSRKHFKEDFDKACH----WL----KQADIVTFP-----------EINLMNE 4594
+E K+L + ED ++ + WL Q +I P EI + +
Sbjct: 2312 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2371
Query: 4595 SSELHTQLAKYQNILEQSPEYENL---LLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQ 4651
++ L+K Q++ ++ P + + L L + + L E L K L
Sbjct: 2372 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE-----LRAKQPDLAPG 2426
Query: 4652 FNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALS 4711
I A V + ++ ++ S +E+ + + E+ A ++ T+L + LS
Sbjct: 2427 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA-LADFNRAWTELT--DWLS 2483
Query: 4712 LQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTE---- 4767
L D + G E ++E+ K++ + +P ++ L+T LK +T
Sbjct: 2484 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP-QLEELITAAQNLKNKTSNQEA 2542
Query: 4768 -----QRVSLLEDTTSAYQEH-EKMCQQLERQLK------SVKEEQSKVNEETLPAEEKL 4815
R+ +++ QEH + QQL LK KEE +V + E
Sbjct: 2543 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 2602
Query: 4816 KMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD---PLAYEKARHQIQSWQGELKLLTS-- 4870
K ++Q K++ L ++D LA + R ++ ++T
Sbjct: 2603 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 2662
Query: 4871 -----AIGETVTECESRMVQS----IDFQTEMSRSLDWLRRVKAELSGPVYLDL----NL 4917
+I + V+E E+ + ++ F ++ + L WL +AE + V D L
Sbjct: 2663 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERL 2720
Query: 4918 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTK-AKELISAD----LEHSLAELSE 4972
+ + ++++ +++Q + + H E K + L +D L+ L ++
Sbjct: 2721 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2780
Query: 4973 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLE-DAQELLQLAGNGLDVESAEEN 5031
++++ ++ L Q +R + Q WL+ EL + A G D + ++
Sbjct: 2781 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2840
Query: 5032 LKSHMEF---FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL--ELRSQRMS 5086
H F T++ + E + T PL G E L Q+ L E R+Q ++
Sbjct: 2841 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL---EGLEKLYQEPRELPPEERAQNVT 2897
Query: 5087 RDSGAQVDLL----QRCTAQWHDYQKAREEVIELMNDTEK-------KLSEFSLLKTSSS 5135
R Q + + ++ D+Q+ +E +E + + ++ KL + ++K S
Sbjct: 2898 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2957
Query: 5136 -------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTV 5188
++ L + KAL + E + + + A QL G S LS ++ +
Sbjct: 2958 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDL 3016
Query: 5189 WQRWTRLRAVAQDQEKILEDA 5209
RW L+ +D+ + L +A
Sbjct: 3017 NTRWKLLQVAVEDRVRQLHEA 3037
Score = 191 bits (486), Expect = 2e-47
Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 6656
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 392 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 450
Query: 6657 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 6715
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 451 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 510
Query: 6716 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 6761
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 511 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570
Query: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 571 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 627
Query: 6822 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6878
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 628 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687
Query: 6879 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 6935
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 688 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 743
Query: 6936 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 6994
I G + +K + + K + ++S + Q V E +D A
Sbjct: 744 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
Query: 6995 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 7046
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 802 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 851
Query: 7047 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 7104
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 852 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 911
Query: 7105 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7164
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 912 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 969
Query: 7165 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7224
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 970 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1029
Query: 7225 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7284
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 1030 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1085
Query: 7285 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 7341
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 1086 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1142
Query: 7342 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 7401
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1143 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1201
Query: 7402 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 7454
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1202 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1261
Query: 7455 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 7512
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1262 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1317
Query: 7513 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 7572
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1318 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1375
Query: 7573 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 7631
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1376 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1422
Query: 7632 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1423 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1473
Query: 7689 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7746
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1474 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1533
Query: 7747 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 7806
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1534 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1593
Query: 7807 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7860
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1594 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1650
Query: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1651 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1699
Query: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1700 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1741
Query: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 8039
+ C +E ++ SE F + S I T A L
Sbjct: 1742 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1776
Query: 8040 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 8094
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1832
Query: 8095 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 8154
R+T + K +++K QQ
Sbjct: 1833 RITD--------------------------------------------ERKREEIKIKQQ 1848
Query: 8155 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 8214
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1849 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1900
Query: 8215 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8274
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1901 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1956
Query: 8275 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 8334
L + + + + M+ +P E +S S ++
Sbjct: 1957 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 1999
Query: 8335 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 8394
I + +AL +++Q N P+L C+ + + + E L
Sbjct: 2000 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 2034
Query: 8395 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 8434
K ++SL G ++ +HS +T Q+A ++R WE + ++ R
Sbjct: 2035 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2094
Query: 8435 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 8493
++++KW++F+ D+ WL + E+ L + Q E + K LKELQ +
Sbjct: 2095 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2149
Query: 8494 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2150 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2209
Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
F + +L LE D + +P++ + + L++ +Q+ + EL Q + L
Sbjct: 2210 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2266
Query: 8613 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 8659
+ +LV+A E D LE K K + L E+ IK+L +KL
Sbjct: 2267 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2326
Query: 8660 LDVSSSQQDLSSWSS 8674
D+ L W S
Sbjct: 2327 EDLEEQLNHLLLWLS 2341
Score = 187 bits (474), Expect = 5e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 5930 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5988
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 413 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 472
Query: 5989 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 6046
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 473 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 528
Query: 6047 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6104
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 529 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 576
Query: 6105 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6161
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 577 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 636
Query: 6162 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6213
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 637 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 692
Query: 6214 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6259
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 693 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 752
Query: 6260 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6303
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 753 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 812
Query: 6304 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6351
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 813 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 870
Query: 6352 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6385
+ L GL E + QS K + + H +Q D
Sbjct: 871 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 930
Query: 6386 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6431
+SA TW+ E +L + + E E L + L ++E
Sbjct: 931 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 990
Query: 6432 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6483
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 991 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1043
Query: 6484 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6542
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 1044 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1103
Query: 6543 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6596
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 1104 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1163
Query: 6597 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6652
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1164 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1222
Query: 6653 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6706
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1223 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1279
Query: 6707 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6762
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1280 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1329
Query: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1330 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1386
Query: 6823 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6871
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1387 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1446
Query: 6872 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 6914
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1447 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1506
Query: 6915 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 6956
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1507 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1566
Query: 6957 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 6986
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1567 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1626
Query: 6987 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 7033
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1627 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1686
Query: 7034 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 7086
+ W + L + + K Q ED++K + E V+
Sbjct: 1687 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1735
Query: 7087 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 7144
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1736 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1795
Query: 7145 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 7198
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1796 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1850
Query: 7199 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 7258
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1851 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1892
Query: 7259 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 7318
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1893 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1937
Query: 7319 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 7358
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1997
Query: 7359 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7416
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 1998 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2057
Query: 7417 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7473
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 2058 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2117
Query: 7474 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 7532
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 2118 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2176
Query: 7533 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2177 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2231
Query: 7593 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 7647
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2232 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2291
Query: 7648 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 7704
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2292 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2351
Query: 7705 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 7762
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2352 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2409
Query: 7763 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 7784
L +L ++ + L E A+
Sbjct: 2410 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2469
Query: 7785 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 7838
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2470 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2525
Query: 7839 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 7887
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2526 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2585
Query: 7888 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 7947
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2586 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2637
Query: 7948 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 8007
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2638 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2693
Query: 8008 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 8056
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2694 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2748
Query: 8057 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8115
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2749 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2808
Query: 8116 ARDSILVWLTEMDLQLT 8132
+ +LVWL D +L+
Sbjct: 2809 SLQELLVWLQLKDDELS 2825
Score = 179 bits (453), Expect = 1e-43
Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)
Query: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 6013
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 329 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 388
Query: 6014 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6073
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 389 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
Query: 6074 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6131
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 447 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 494
Query: 6132 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6176
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 495 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 554
Query: 6177 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6236
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 555 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 601
Query: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6295
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 602 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 643
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6355
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 644 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 692
Query: 6356 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 693 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 741
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6462
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
Query: 6463 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6514
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 802 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 857
Query: 6515 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6570
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 858 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917
Query: 6571 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6622
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6678
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037
Query: 6679 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6738
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1093
Query: 6739 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6795
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 1094 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1153
Query: 6796 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6854
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1154 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1211
Query: 6855 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6914
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1212 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1269
Query: 6915 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6974
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1270 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1318
Query: 6975 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 7034
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1319 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1378
Query: 7035 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7085
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1379 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1436
Query: 7086 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7142
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1437 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1475
Query: 7143 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7202
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1476 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1530
Query: 7203 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7262
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1531 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1587
Query: 7263 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7319
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1588 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1641
Query: 7320 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7375
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1642 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1698
Query: 7376 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7429
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1699 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1752
Query: 7430 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7488
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1753 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1810
Query: 7489 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7548
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1811 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1858
Query: 7549 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7608
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1859 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1907
Query: 7609 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7668
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1908 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1965
Query: 7669 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7718
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1966 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2025
Query: 7719 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7765
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 2026 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2085
Query: 7766 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7820
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 2086 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2142
Query: 7821 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7880
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2143 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2202
Query: 7881 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7940
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2203 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2260
Query: 7941 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7995
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2261 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2316
Query: 7996 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 8037
+ +L +K D + WL + F I AK+
Sbjct: 2317 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2376
Query: 8038 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8086
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2435
Query: 8087 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8135
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2436 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2495
Query: 8136 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8194
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555
Query: 8195 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8254
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2556 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2615
Query: 8255 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 8310
+ LA+ LR +W + D++ DL + R ++D
Sbjct: 2616 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2658
Query: 8311 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 8363
++ + +S +ALE R L + LD +F + + T N+++ T
Sbjct: 2659 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2718
Query: 8364 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 8417
L+ S K + L GE + D L+ ++ SL G + + + +
Sbjct: 2719 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2778
Query: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477
+W L+ ++L+ ++ + +W++ + L + WL ++EL + + + D
Sbjct: 2779 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2836
Query: 8478 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 8516
++ Q + ++ + ++ +I+S F E
Sbjct: 2837 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2896
Query: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 8576
+R L+ + ++N W+++ +W+ + + L + Q E + L L L + K
Sbjct: 2897 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2956
Query: 8577 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
P+ +L + LQDH +++ ++ E+ + V+ + D++ QL
Sbjct: 2957 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2998
Score = 179 bits (453), Expect = 1e-43
Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)
Query: 6799 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 6858
RYQ+ +++ WL SA+D L Q + ++E+V+D + + ++ A +
Sbjct: 339 RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 394
Query: 6859 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 6915
+L G++L+ +L + + ++ +++ ++S+W L Q LH++ MD
Sbjct: 395 ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 452
Query: 6916 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 6975
+ E+ W++ E +K E+ + + +Q++K + D+ +Q+ V+ + V+
Sbjct: 453 LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511
Query: 6976 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 7035
+ D S EQL + W + ++ LL+ +L W
Sbjct: 512 VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
Query: 7036 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 7090
W +E + + H G DQ + ++L+ L+ ++ K++ + K+ +Q+ L+ ++
Sbjct: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 628
Query: 7091 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 7121
NK +S V +T L QT + + +
Sbjct: 629 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 688
Query: 7122 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 7169
+IL+K ++ ++ D +++ + E ++R + S E A+ +
Sbjct: 689 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 748
Query: 7170 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 7218
N +L++ + ER +KF ++ Q++ E +++ +++N
Sbjct: 749 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 806
Query: 7219 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 7275
RW + ++E+L W Y++ + +QQ E T LK
Sbjct: 807 RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 858
Query: 7276 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 7335
+ + ++ C D + L ++ + L LK++ + +D ++ + H
Sbjct: 859 PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 916
Query: 7336 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7393
+ + ++ LQ L + +++ A+ W+ ++E L S +D +++R+
Sbjct: 917 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 975
Query: 7394 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 7447
EL+ L L+ E+ + P ++ K + + W +SSQ E
Sbjct: 976 GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 1035
Query: 7448 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 7505
KL+ + + + +T +++ + + L E G+ + L +Q + L +++
Sbjct: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095
Query: 7506 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 7565
+ Q L+S+ GQ++ + + + +L L+ QW + ++ R+ + + +
Sbjct: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
Query: 7566 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 7623
++ ++ +W+ E YL P LQ+A +E++ ++ +++ L
Sbjct: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1212
Query: 7624 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 7683
E+ ++ A A+ AL+ EL + ++ RL + K L + W + +
Sbjct: 1213 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1272
Query: 7684 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 7741
+ + L FK K ++++P EE+ LEN + D+ Q+ +L TL+
Sbjct: 1273 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1329
Query: 7742 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 7801
D++ +NE +E +W EL H+ ++RRQ++ E+ + A +EK+ L
Sbjct: 1330 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1377
Query: 7802 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 7856
I+E + + K IA +K+ QM + K SHE E++
Sbjct: 1378 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1424
Query: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 7910
K + + Q +L I KKL++ + + K + + L ++ L
Sbjct: 1425 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1483
Query: 7911 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7970
+ S E +Q +LN L + + + + V V+ ++ +
Sbjct: 1484 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1538
Query: 7971 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 8030
+ L + + A ER+ ++E+ +L +K + + +WL +++ S+
Sbjct: 1539 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1598
Query: 8031 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 8085
+ + E+ +A Q+++ + L+ I + L +E + SL
Sbjct: 1599 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1652
Query: 8086 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 8145
N W + R L L + E F+ D I W+ + D L E +
Sbjct: 1653 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1712
Query: 8146 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 8205
+K+LKA +I K++ Q L+ ++E ++ EL + R++
Sbjct: 1713 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1769
Query: 8206 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 8260
+ L D L E E++ L + ++ D + D+ + + +
Sbjct: 1770 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1829
Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 8319
L Q + ER + + + ++ +DL S +AL + Q Y R
Sbjct: 1830 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1880
Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
A L +E ++ L + D+ + I++ + ++ K + +G + G
Sbjct: 1881 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1937
Query: 8380 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 8439
+ + +L + +E E F L+ + T V + ++ + + E+ +
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1995
Query: 8440 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 8499
+ +++ + L + E+ L + D + + Q + LK ++ ++ I
Sbjct: 1996 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 2048
Query: 8500 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 8556
I+ Q+ + R LQ+ LSQ++ +W++V + ++ +G ++ + + FH
Sbjct: 2049 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2108
Query: 8557 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 8615
++ + L E R+ I N + + + K+L + + Q V +L
Sbjct: 2109 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2161
Query: 8616 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 8674
+++ + TD +EK+ + R + + K++S K LE+ ++ S Q+DL+ +
Sbjct: 2162 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2221
Query: 8675 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 8702
+E D S+ G+ ++K + K
Sbjct: 2222 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2250
Score = 179 bits (453), Expect = 1e-43
Identities = 533/2827 (18%), Positives = 1093/2827 (38%), Gaps = 366/2827 (12%)
Query: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5311
H+ ++++L Q +G + Q ++ G + EE + +++ + R CL +
Sbjct: 378 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 436
Query: 5312 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5370
K +N V +L+++++ E + W+ +T+E +E + +L+ L + H
Sbjct: 437 KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 489
Query: 5371 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5426
+ E + +EQ + L ++ E S A AL+ +++ D+ + + E
Sbjct: 490 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549
Query: 5427 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5486
Q++ + Q+L ++ L K D V + T E+ KL L A ++K
Sbjct: 550 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 608
Query: 5487 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5546
+ +GKL L Q + +N+ S + + L+ + + +++ +EK
Sbjct: 609 ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 656
Query: 5547 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5606
S +Q+ + Q L + T ++ +T+V E++ +
Sbjct: 657 -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 694
Query: 5607 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
A+ EEL + + + ++ K+ + ++ +L + + +++A L SPE +
Sbjct: 695 AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 749
Query: 5667 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5725
S + ++ +E + K + + Q A R + +V + A +++ + +L
Sbjct: 750 GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 807
Query: 5726 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5779
I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S +++Q+
Sbjct: 808 WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 867
Query: 5780 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5839
++ ++ G Q QI L K + + +K K +G LD + +
Sbjct: 868 ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 911
Query: 5840 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5892
+ V R L L P+ + + + S ++ TD +
Sbjct: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
Query: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5950
Q + QAL + + + + ST+ + + E S ++ +++ W+ L +
Sbjct: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1031
Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 6007
+ E + L E + + +K Q+ +Q++ M +++ L E P G S + Q+ + + L+
Sbjct: 1032 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1091
Query: 6008 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 6067
+I +Q +N + +++ +E A+P L++ L L + + + +++
Sbjct: 1092 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147
Query: 6068 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6124
L+ L + Q+ + + +A+E + T L A+ K + Q
Sbjct: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207
Query: 6125 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 6184
+L E V+A + V E L E + T + + L +L +L E+ H
Sbjct: 1208 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKTLEEVWACWH 1265
Query: 6185 DKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 6243
+ ++ + E + L T++ PG E E+ + L
Sbjct: 1266 ELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEVLDS 1304
Query: 6244 QKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 6303
++L+R +I I A+T D G +++++EL + +W LH
Sbjct: 1305 LENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWRELH 1351
Query: 6304 QEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSAVTS 6353
+E +QKLL+ ++ QE Q + ++ L+ K D Q+ + S
Sbjct: 1352 EEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 1411
Query: 6354 LLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLFVAT 6405
L + EE+ + G + I + QK VS + E+RL +
Sbjct: 1412 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESK 1471
Query: 6406 ALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-PENG 6448
+L E ET QE+ L K + E+ E++ Q +
Sbjct: 1472 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1531
Query: 6449 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 6508
+N +++ + L + L + V +R Q+++ L+ + ++ VL LA +
Sbjct: 1532 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1591
Query: 6509 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6568
++ A E + + + KE + + LK +V + L K + + +
Sbjct: 1592 KRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKETLVE 1646
Query: 6569 ELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEKMAG 6611
+ + ++ S S + L L +Y++ ++ AD L EK
Sbjct: 1647 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1706
Query: 6612 DQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6669
QK ++ K E+ + K + M RK++ + +EL +
Sbjct: 1707 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SELNHR 1759
Query: 6670 ASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--NEDR 6724
+A+ R K + L+ L++ ++ + LE +E+ I V L EE N+D
Sbjct: 1760 FAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 1812
Query: 6725 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMS 6784
D + L + Q + + D+ KR I I L+++ N L + K
Sbjct: 1813 NEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1869
Query: 6785 KELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVRDHL 6839
+ H+ W +Y+ ++ DL+ L + +L + + + +EL+ ++ L
Sbjct: 1870 EISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEEL 1922
Query: 6840 NAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSRIDS 6886
NA ++ + + + + S Q RL T+R E + +
Sbjct: 1923 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1982
Query: 6887 QWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6943
+ L ++ +P+ + E H Q A+ EV ++ + + ED K
Sbjct: 1983 EDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQEESL 2034
Query: 6944 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 7003
K I + LQ+ G +IDI + T + LQ S+ VE + E L ++ W
Sbjct: 2035 KNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLDFQW 2081
Query: 7004 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQNAL 7061
+ + + ++ + +E W + +++ W E+ L+ Q + A + L
Sbjct: 2082 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 2141
Query: 7062 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7121
K +L+D I ++ V + G +IQ + +SI+ L L W + +
Sbjct: 2142 K---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 2198
Query: 7122 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 7181
K L+ + S + ++ +L EA +++ L G + ++ +++ ++ L ++L
Sbjct: 2199 KKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELP 2257
Query: 7182 KQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQSSK 7235
++ L++ +L P + L N LK+ N++W L E+ E K
Sbjct: 2258 LRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIK 2317
Query: 7236 ALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ--DCN 7287
L QL ++ +D +Q S ++ Q + N+ + D+ + E+A + D
Sbjct: 2318 DLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQPDVE 2376
Query: 7288 DLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AASAIQ 7323
++L KG K+ L +L + K Q++ A AS Q
Sbjct: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2436
Query: 7324 SDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 7381
+ L ++Q + E A+ K + +SL V F ++ L W+ +++++ Q
Sbjct: 2437 TVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2495
Query: 7382 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQNLN 7434
DL I E + + K M P L+ L L +++E + R++ +
Sbjct: 2496 -VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2554
Query: 7435 RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ 7494
W + R +L L +LE E + L Q KL G Y Q+
Sbjct: 2555 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2614
Query: 7495 RAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7552
+ E Q RQ + + + +LL DD + ++ ++ W+ + +R
Sbjct: 2615 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2674
Query: 7553 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE- 7611
+R ++ R Q++ EK WL E + + ++ R L D KE
Sbjct: 2675 EREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGVKEL 2730
Query: 7612 -KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLE 7662
K + QG Y E +++L S + +A LQ L + KW +
Sbjct: 2731 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2790
Query: 7663 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQMRC 7714
+ L W++ + + L L+ +LS+ P ++H R
Sbjct: 2791 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2850
Query: 7715 KELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELLQRQ 7760
+ + V T + ++ L + L A +++ +L ++ E + +
Sbjct: 2851 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2910
Query: 7761 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEK 7817
WE+L + +++I E L E EL L Q E GD+LI+ + +
Sbjct: 2911 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2970
Query: 7818 LK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 7875
L+ K + EIA +EN + + +L + + L +N RW+ L +
Sbjct: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVED 3029
Query: 7876 RVKKLKE 7882
RV++L E
Sbjct: 3030 RVRQLHE 3036
Score = 176 bits (446), Expect = 9e-43
Identities = 468/2732 (17%), Positives = 1059/2732 (38%), Gaps = 408/2732 (14%)
Query: 1244 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1302
S E+ + E+ E + D + E + L HQ + I Q+ G
Sbjct: 353 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 404
Query: 1303 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1355
G L + E++ L S + L S E+Q R+ + L+ + E N + + +
Sbjct: 405 TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 463
Query: 1356 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1409
+T E L LE L +++Q K + E V+ +L V E+S G
Sbjct: 464 EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 518
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
L++Q K + ++ + E+ ++ + KW S W++EKE +
Sbjct: 519 DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 578
Query: 1470 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527
N + T+ +M S K+ + + + LE++ QS + + + K
Sbjct: 579 NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 630
Query: 1528 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
+ + E L A+C + + QK E++ +I Q+V+ + L T
Sbjct: 631 SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 673
Query: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1646
+T +E++++ T R+ + +E Q K+R
Sbjct: 674 QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 708
Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1706
Q +++ + +RL+ +++ +W+ R EA SPE I + + A++ E
Sbjct: 709 QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 765
Query: 1707 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761
+A + KL S ++ + + +K EQL+ RW + Q++++R+N+L+
Sbjct: 766 --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 823
Query: 1762 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
+++A + QQ +++ + W+K+ + T SE + + Q+ + KD +
Sbjct: 824 YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 878
Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1874
+ +++ L+ L G+ L F++ V+ R+ L + + L
Sbjct: 879 LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 936
Query: 1875 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1930
+ ++S I ++Q T + ++ + +++E+ L + +L+ L +
Sbjct: 937 PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 996
Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1990
+ + K SE ++ +++ G +++ + L + + + Q+ + L
Sbjct: 997 TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1056
Query: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2049
K + +++ +E + L+++L+ L ++ + + L + + ++I + +
Sbjct: 1057 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1116
Query: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2109
FA ++ E+ L WD + ++ + G ++ Q S + + + A
Sbjct: 1117 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1176
Query: 2110 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168
+ R K ++L+ A + + AK + K+ + T ++++ + +K
Sbjct: 1177 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1233
Query: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228
++E+ + + +L L + W ++LS ++ W N ++ + +
Sbjct: 1234 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1289
Query: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2288
N E + E ++N E+ +++ L + + +L E +
Sbjct: 1290 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349
Query: 2289 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347
V + L + + QS Q EK ++ I T +++ L ++ A + +
Sbjct: 1350 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1404
Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
E Q QS+++S + +L + K H+ E+ R ++ + + + + K + + +
Sbjct: 1405 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1461
Query: 2408 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
+F + +QE + K ++ + +V++++L+ N+ S+S+ +S+++ V
Sbjct: 1462 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1519
Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
+ G+ + + + E++T + + + KQ L+ C + L
Sbjct: 1520 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1579
Query: 2528 NLWI----HEMEERFNTENL----------GESKQHIPEKK----NEVHKVEMFLGELLA 2569
W+ E+ +R E + G++ Q EK+ + +V L +L
Sbjct: 1580 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1639
Query: 2570 ARESL--DKLS------------------------------------------QRGQLLS 2585
+E+L DKLS Q LL
Sbjct: 1640 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1699
Query: 2586 EEGHGAGQEGRLCSQLLTSHQNLLR----MTKEKLRSCQVALQEH--EALEEALQSMWFW 2639
E Q+ + L + N +R T+++ + +H + +E + +
Sbjct: 1700 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1759
Query: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAI-------------- 2685
AI R+ ++++ K+ LE+ S IQ LL E E++ + +
Sbjct: 1760 FAAISHRIKTGKASIPLKE-LEQFNSDIQK-LLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1817
Query: 2686 GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES--------VISQWND 2737
G ++ L+ + QR+ + ++ ++ + +A L S + QW
Sbjct: 1818 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1877
Query: 2738 YVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFV------LLDHLQSILSEAEDHTRALH 2791
Y + + L + ++ +++K+ +P+ K K + + L ++ +AE +
Sbjct: 1878 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1937
Query: 2792 RLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2851
+ + ++ + + + F I TV +E M + E + + Y+ + +
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTY- 1996
Query: 2852 FTDWLHSAK-----EELHRWSDM-SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAP 2905
T+ H ++ E+L D+ + D K+ +K + DS + + R+ + S
Sbjct: 1997 LTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 2056
Query: 2906 EVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
Q+ T + + L W++ V++M Q G+ +
Sbjct: 2057 AALQSATPVERVKLQEALSQLDFQWEK---------------VNKMYKDRQ---GRFDRS 2098
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG------QEILDALQKAEPRTEDL 3019
+ +F +K + Q LT E +I E W +E+ D + + + L
Sbjct: 2099 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 2158
Query: 3020 KSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQAS---KGCQNKEQILQQRFRKAFR 3074
+ E+ + S D S K+ L + +C Q S K + ++ IL + F++
Sbjct: 2159 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSE-FQRDLN 2217
Query: 3075 DFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG--ELLS 3132
+F WL A + + P ++ L++++ + E Q L + G L+S
Sbjct: 2218 EFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2276
Query: 3133 TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALE-------NLKIQMKDFEVSAEPI 3185
++ E+ ++ K+ W L +K+ +E L+ +++D E +
Sbjct: 2277 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2336
Query: 3186 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3245
WLS + +Y+ P + +Q + +P + + K Q L++ +
Sbjct: 2337 LLWLSPIRNQL-----EIYNQP-NQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKP 2390
Query: 3246 ASKSFRHRVSQLSSQYLALSNLTKEKVSR-------LDRIVAEHNQ-------------- 3284
A++ + ++ LSS++ A++ L +E ++ L I A Q
Sbjct: 2391 ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 2450
Query: 3285 --------------------FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
F+ EL DW++ ++ S D ++ +K +
Sbjct: 2451 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 2510
Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIRCKSQ 3383
A + +++ Q++ ++T +++ TS + T I +++ +++ W + + Q
Sbjct: 2511 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 2570
Query: 3384 LEGAL---SKWTSYQDGVRQFSG--------W------MDSMEANLNESERQHAELRDKT 3426
L L ++W ++ Q G W +D+++ + E+++ +LR
Sbjct: 2571 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 2630
Query: 3427 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3486
T + A L ++L S +T +V H +T +++ +R+I +R E
Sbjct: 2631 TNVDVANDLALKLLRDYSADDTRKV-------HMIT----ENINASWRSIHKRVSEREAA 2679
Query: 3487 SEKLVRLHQEYQRDLKAFEVWLGQEQ-----------------------EKLDQYSVLEG 3523
E+ RL Q++ DL+ F WL + + E + Q+ L+G
Sbjct: 2680 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2739
Query: 3524 DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQ 3583
+ H +L E Q +L S+ + + V+ R L+++ W +
Sbjct: 2740 EIEAHTDVYHNLDE------NSQKILRSLEGSDDAVL-------LQRRLDNMNFKWSELR 2786
Query: 3584 HRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS---------PRTRRQS--NRA 3632
+ R+ ++ + + Q++ WL+ ++++S P ++Q+ +RA
Sbjct: 2787 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA 2846
Query: 3633 TK-EIQLHQ--MKKWHEEVTAYRDE-----VEEVGARAQEILDE---SHVNSRMGCQATQ 3681
K E++ + + E V + E +E++ +E+ E +V + QA +
Sbjct: 2847 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE 2906
Query: 3682 LTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
+ + ++ L L + + ++E ++ L+E + +
Sbjct: 2907 VNTEWEKLNLHSADWQRKIDETLERLQELQEA 2938
Score = 167 bits (423), Expect = 4e-40
Identities = 525/3002 (17%), Positives = 1145/3002 (38%), Gaps = 438/3002 (14%)
Query: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4195
E+ +L A+ LQ +++E + ++ + ++ L + Q V I++
Sbjct: 346 EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 403
Query: 4196 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4249
KL++ EE+ +++N LN +W + +QSN + + Q+ ++ +D +
Sbjct: 404 GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 463
Query: 4250 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
E + + + E LE LK+ +Q+ K EDL+ Q+ + +L
Sbjct: 464 E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 507
Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4369
+V +++S + LE E+L V+ R+ + W E++
Sbjct: 508 HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 548
Query: 4370 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4429
LL D L L +Q L + + + + + + + + LS
Sbjct: 549 -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 595
Query: 4430 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4488
Q +DL ++++ + K S K Q L++ + S Q+ E + ++ D+
Sbjct: 596 LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 650
Query: 4489 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4548
V K K+ ++ T Q +T E + VT +E+ V +EL
Sbjct: 651 VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 701
Query: 4549 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4607
+ +++ + RK D + W+ +++ ++ PE + + K
Sbjct: 702 PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 761
Query: 4608 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
I + E L R+ Q ++ + N SE+LN+ +F +++ +
Sbjct: 762 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 821
Query: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4722
I + L ++TT + + L+ Q S+ PT A++ L + C+ ++
Sbjct: 822 LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 875
Query: 4723 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4777
++GL ++ L + + GQ P D T + + + E+ + + DT
Sbjct: 876 LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 935
Query: 4778 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4831
+ E M QQ E +L Q V + + E++L +L SLQ+
Sbjct: 936 PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 991
Query: 4832 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4891
L ++ +++++ K + + + +G K L+S + E + E +M + Q
Sbjct: 992 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1051
Query: 4892 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4951
+ W+ V L + + +++++++ ++ ++Q+ +N+++ ++
Sbjct: 1052 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1111
Query: 4952 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 5011
+A+ ++ LE L EL+ + + + R+ L + + ++W+
Sbjct: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
Query: 5012 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 5068
A+E + + ++ +E K+ E +++ ++ L +++ +I P +
Sbjct: 1172 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1229
Query: 5069 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5128
E L++++ +L Q + + L+ A WH+ E+ + +N+ E F
Sbjct: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1284
Query: 5129 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5183
L T + E++SE V++S + E+ +Q+ T ++
Sbjct: 1285 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1338
Query: 5184 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5243
+ T RW L A ++K+LE ++ + E + + +L A+K
Sbjct: 1339 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1398
Query: 5244 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5303
A++ ++ Q L +S L++ G+E Q + + D
Sbjct: 1399 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAA--QRVLSQIDV 1442
Query: 5304 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE--------IDA 5355
+ V +L ++ E ++ K + E K +L P +E + +
Sbjct: 1443 AQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEVKMHL--PALETKSVEQEVVQS 1496
Query: 5356 QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQD 5415
QL L + + +E + + ++ T P EL ++ + L +++
Sbjct: 1497 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---NELGA 1553
Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG---- 5471
K+ E +Q +LSR+++K +LT+ A TD + ++ + + LD
Sbjct: 1554 KVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1609
Query: 5472 --CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAENRLSK 5521
K +E K + + G+ LGK KL+ L+ I +AE L+
Sbjct: 1610 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNL 1669
Query: 5522 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5581
L + H+E +++ ++ I KWI +A L + Q +E + + L E +I
Sbjct: 1670 LLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELNDIRP 1725
Query: 5582 ELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
++++ ++ L + +C + + Q++EL + IK ++ K++++F
Sbjct: 1726 KVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFN 1783
Query: 5639 AELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV------QAV 5689
++++KL LE Q L + + ++ + LL ++L+ ++ + +
Sbjct: 1784 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1843
Query: 5690 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH 5749
++ Q L+ + + L + +++A + H Q + + E+++
Sbjct: 1844 KIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1898
Query: 5750 L-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL--NSKC 5802
L ++ I+ RE++ K + ++ QA+ + A ++ Q Q++ +
Sbjct: 1899 LPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWREIES 1957
Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE 5862
K + + + TV E E + TED+ E+ PS + + + T +S
Sbjct: 1958 KFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVSQALL 2008
Query: 5863 ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ 5922
E +++P C ++I S+ R+ IH +A+
Sbjct: 2009 E-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKKTAAL 2059
Query: 5923 EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI 5982
+ P L L WE + + ++Q ++E+ +++ ++ + +
Sbjct: 2060 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2119
Query: 5983 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSESCEAD 6036
E L ++ P + EH + LQD I + Q ++ EE++ +S + D
Sbjct: 2120 EQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 2173
Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
+ LQ L L R + + S +++ LEE Q+ L ++ + +E
Sbjct: 2174 AS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDLNEFV 2220
Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
WL L P KE ++ +L + ++ E+ + L +L+ +L+
Sbjct: 2221 LWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2279
Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSPGVQE 6214
+ +E ++L KL++ +++ RAL +KQ ++ ++ + E ++ Q +
Sbjct: 2280 -SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLL 2338
Query: 6215 WLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6271
WL+ R + Q Q +E E + ++ + + S+G+ +
Sbjct: 2339 WLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY------------ 2386
Query: 6272 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 6331
EKP A ++ K E L E+ +LLQ + ++ +
Sbjct: 2387 KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD--------- 2422
Query: 6332 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6391
L G+ G PTQ + VT + A ++ S S+ LE +
Sbjct: 2423 LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADFNRAW 2475
Query: 6392 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6451
T L D L + + +Q ++ D+++++E + K K
Sbjct: 2476 TELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD--------- 2515
Query: 6452 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6511
+ QR Q++E + N +N TS + + II
Sbjct: 2516 --------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII---- 2546
Query: 6512 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6571
++IE IQ D ++E LQ + + E+ K
Sbjct: 2547 --------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK--------- 2576
Query: 6572 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQLLDK 6629
Q L K + E+ L LE+ +E G + K+ E +QL
Sbjct: 2577 --------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQLAKD 2625
Query: 6630 HKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE 6689
+++ ++ L L R + +K + A ++ KR +R LE E
Sbjct: 2626 LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE---E 2682
Query: 6690 TWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLKSSLN 6740
T L + +L + L + + + ++++ ++RL+ + + +Q L+ +
Sbjct: 2683 THRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 2742
Query: 6741 EYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLETILKH 6796
+ + + ++ +++L S+ SD L+ +L+ + W K LE
Sbjct: 2743 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 2802
Query: 6797 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6856
W R +L+ WLQ D L + + + V+ + F +E+ + +
Sbjct: 2803 WKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI 2858
Query: 6857 SSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDLLTNI 6895
S L T L + ++ T LR + ++++W L +
Sbjct: 2859 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 2918
Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
Q K+ + +++L ++ + + L + + K + ++ ++L+K K
Sbjct: 2919 ADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 2976
Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015
+ +I + V VN Q+++ ++ + + + +N W++LQ V ++++
Sbjct: 2977 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVR 3032
Query: 7016 LL 7017
L
Sbjct: 3033 QL 3034
Score = 162 bits (409), Expect = 2e-38
Identities = 468/2591 (18%), Positives = 974/2591 (37%), Gaps = 351/2591 (13%)
Query: 600 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-------NQSENAKKDFFRNLPH 652
E +S S L E N DRY + + +WL AE L N E K F + +
Sbjct: 322 EDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGY 381
Query: 653 WIQQHTAMNDAGNFL--------IETCDEMVSRDLKQQLLLLNGRW---RELFMEVKQYA 701
+ GN L E ++++Q+ LLN RW R ME +
Sbjct: 382 MMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL 441
Query: 702 QADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQ-------DLEDIEQ 754
MD ++ + L+ K EPL ++K +Q DLE +
Sbjct: 442 HRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQV 501
Query: 755 RVPVMDAQYKIITKTAHLITKESPQEEGK---EMFATMSKLKE--------------QLT 797
RV + ++ +++ + +E+ K + +A + + E +LT
Sbjct: 502 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
Query: 798 KVKECYSPLLYESQQLLIPLEELE-KQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 856
+ + +S L E + + + K SL K+ + LE++ QS Q
Sbjct: 562 EEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQ 621
Query: 857 ELLACQENCKKT-----------------LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQR 899
+LL+ +N T + +EK + + + VT + QT +
Sbjct: 622 DLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQTTVME 679
Query: 900 QIADIHVAFQSMVKKTGDW--------KKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 951
+ + Q +VK + K+ + +S + K+ + EL + ++ L+
Sbjct: 680 TVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ 739
Query: 952 EKGDPEELLRRHTEFFSQLDQRVLNAF----------LKACDELTDILPEQ------EQQ 995
PE + R FS L ++V NA L+ L EQ
Sbjct: 740 S---PEFAIFRKEGNFSDLKEKV-NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD 795
Query: 996 GLQEAVRKLHKQWKD---LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQE 1052
+++A +L+ +W + L E L + + L +E+ T + K+ P
Sbjct: 796 SIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTT 855
Query: 1053 GSEKI-IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAA 1111
SE IK D+ RL ++ +L ++ G + L A
Sbjct: 856 PSEPTAIKSQLKICKDE------VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA 909
Query: 1112 IDSTYRKLMEDPDKWKD-------------YTSRFSEFSSWISTNETQLKGIKGEAIDTA 1158
+ ++++ D + Y S +W+ +ET+L + D
Sbjct: 910 FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYE 969
Query: 1159 NHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALV 1218
+ ++ +++ + ++ L +L + +K +++ + ++K E ++ +K L
Sbjct: 970 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1029
Query: 1219 TLLSE----VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENL---FEA 1271
+ L E +E+ ++ + + +K + E+ ++E+ + D+E L +
Sbjct: 1030 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV---DVFLKEEWPALGDSEILKKQLKQ 1086
Query: 1272 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ 1331
+LL+ Q + + Q+I + E R EL++L + D + + +
Sbjct: 1087 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKELNTQWDHMCQQVYAR 1144
Query: 1332 ERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1391
+ ++ L K + + + ++ Q + E +L EL++ E KR +
Sbjct: 1145 KEALKGGLEKTVSLQKDLSEMHEWMTQ---AEEEYLERDFEYKTPDELQKAVEEMKRAKE 1201
Query: 1392 IAVQAENLVKEASE------IPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1445
A Q E VK +E P ++ L+++ +++ + L L KT+E V
Sbjct: 1202 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1261
Query: 1446 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEE 1505
W S E + W+ E E +L E + +I + +E+ +
Sbjct: 1262 ACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE----EISEVLDSLENLMRHSEDNPN 1317
Query: 1506 EAQSFAQFVTTG--ESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1563
+ + AQ +T G I +L EL E A + + + Q+ E++L
Sbjct: 1318 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1377
Query: 1564 IQQSVSEFEDKLAVPI--------------KICSSATE---TYKVLQEHMDLCQALESLS 1606
IQ+S++ + +LA I KI S T + + +++H +A + +
Sbjct: 1378 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVL 1437
Query: 1607 SAITAFSASARKVVNRDSCVQEAAALQQQYED---ILRRAKERQTALENLLAHWQRLEKE 1663
S I + V + Q+ A +Q+ ++ IL K ALE + ++ +
Sbjct: 1438 SQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1497
Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
L+ + + S EM I R Q++Q Q E +
Sbjct: 1498 LNHCVNLYKSLSEVKSEVEMVIKTGR-------QIVQKKQTENPKELD------------ 1538
Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
+ V +KLH +L + + Q + K + + + E E W+
Sbjct: 1539 ------ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE-------WLAA 1585
Query: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
EL S + M + A ++ + E++ + HL + +G A L +
Sbjct: 1586 TDMELTKRSAVEGMPSNL-----DSEVAWGKATQKEIEKQKVHLKSITEVGEA--LKTVL 1638
Query: 1844 GKAEDCFQLFEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVE-ATNSMNKNE 1901
GK E L E+ ++ +A+ S E+L + Q V+ T + + +
Sbjct: 1639 GKKE---TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQAD 1695
Query: 1902 SDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVER 1961
+ L E + Q L+ L+ I K + +Q + A C
Sbjct: 1696 TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD-----STRDQAANLMANRGDHC----- 1745
Query: 1962 IQNLLGTKQSEAD-ALAVLKKAFQDQKEEL-LKSIEDIEERTDKERLKEPTRQALQQRLR 2019
+ L+ + SE + A + + K + LK +E +D ++L EP +QQ +
Sbjct: 1746 -RKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF--NSDIQKLLEPLEAEIQQGVN 1802
Query: 2020 V----FNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRL 2073
+ FN +D +E + L + + Q+ D E+ + L+ + K L
Sbjct: 1803 LKEEDFN--KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1860
Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2133
+ + + + +Y+ + K L++ + + +D+ +K + + K
Sbjct: 1861 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1920
Query: 2134 KMNYKQKDLDNFTSKGKHLLSELKKIHSS----------------DFSLVKTDMESTVDK 2177
++N ++ + + G + E +I S +F+ + T E T+
Sbjct: 1921 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETM-- 1978
Query: 2178 WLDVSEKLEENMDRL-RVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEEL 2236
+ ++E + + + L+ V E+E N P + + ++ + EE
Sbjct: 1979 -MVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN--APDLC--AKDFEDLFKQEES 2033
Query: 2237 LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAK 2296
LK + ++ + R++ +HSK K TP + ++ L Q +++ ++ K
Sbjct: 2034 LKNIKDSLQQSSGRIDIIHSK----KTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2089
Query: 2297 GTLKDFTAQSTQVEKFINDI---TTWFTKVEESLMNCAQNETCEALK---KVKDIQKELQ 2350
F + +F DI W T+ E+ L E E K +K++Q +
Sbjct: 2090 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2149
Query: 2351 SQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL-IKKHEAVSQLCS-KTQASLQESLE 2408
+Q+ + + + ++ + L + L ++ E QL K + Q+++
Sbjct: 2150 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2209
Query: 2409 KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQ 2468
F + EF W A A + G + L+ KL ++ +++ + Q L + +
Sbjct: 2210 SEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNE 2268
Query: 2469 EGQTLY--AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
G + A +S + ++ ++ + N Q +K +AL + E+ +
Sbjct: 2269 TGGPVLVSAPISPEEQDKLENKLKQTN-------LQWIKVSRALPEKQGEIEA------- 2314
Query: 2527 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
++LG+ ++ + + + +++ + ++L + E ++ +Q G +
Sbjct: 2315 ------------QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 2362
Query: 2587 EGHGAGQEGRL-CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2642
E A Q + ++L+ Q+L + T+ R + E +A+ LQ + +A
Sbjct: 2363 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL----RA 2418
Query: 2643 IQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQ 2700
Q LA +T+G+ T + ++ + ++ K KL M ++ AL N+
Sbjct: 2419 KQPDLAPGLTTIGASPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2476
Query: 2701 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2760
+ W ++ + +Q + + N+ + ++ Q +E
Sbjct: 2477 ELTD---------WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE---------- 2517
Query: 2761 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2820
Q +P L+E +L++ S E T R+ E ++ Q
Sbjct: 2518 QRRPQLEELITAAQNLKNKTSNQEARTIITDRI---------------------ERIQNQ 2556
Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
++++ + + +++ E++KD +L+A E L A+ +L W + A QKK+
Sbjct: 2557 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 2616
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
++ K+L + + LA ++ ++ +A +H + + A W+ V +
Sbjct: 2617 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 2676
Query: 2941 QSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVE 2997
++ LE L+ Q L ++F +A L +A E + +L+ ++ LLE +E+++
Sbjct: 2677 EAALEETHRLLQQFPLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMK 2732
Query: 2998 CWHKGQEILDA 3008
W Q ++A
Sbjct: 2733 QWQDLQGEIEA 2743
Score = 159 bits (402), Expect = 1e-37
Identities = 533/2914 (18%), Positives = 1109/2914 (38%), Gaps = 456/2914 (15%)
Query: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3120
+ ++ R++ A + WL++A+ T +I ++ V + ++ + Q +
Sbjct: 332 ESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGR 391
Query: 3121 LNMMLSKGELL--STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDF 3178
+ +L G L + L++++ +Q ++ W+ +K+S L + + +++
Sbjct: 392 VGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQ 451
Query: 3179 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3236
++ + + DWL+KTE+ + DL +R+ Q+ + + E++ + ++N L
Sbjct: 452 KL--KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
Query: 3237 AQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEK-------VSRLDRIVAEHNQFSL 3287
+ E G A+ + ++ L ++ + T+++ + + R+ E FS
Sbjct: 510 VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 569
Query: 3288 GIKELQDWMT--------DAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE--KEIQM 3337
+ E +D + D ML S K+ L+ + + L S+KQ+ ++
Sbjct: 570 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 629
Query: 3338 KMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA--GIRCKSQLEGALSKWTSYQ 3395
K + + E+ L N + +Q+ +S + ++ + + + +E + T Q
Sbjct: 630 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQ 689
Query: 3396 DGVRQFSGWMDSMEANLNESERQHAELRDKT----TMLGKAKLLNEEVL----------- 3440
V+ + +E+R + T L +E VL
Sbjct: 690 ILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 749
Query: 3441 -SYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQER-------AKEAVTKSEKLVR 3492
++S L E + E + +LQD +A+ E+ A SE+L
Sbjct: 750 GNFSDLKEKVNAIEREKAEKF---RKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNS 806
Query: 3493 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3552
E+ + L WL + + Y+ L+ TT + ++Q + S
Sbjct: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQ-QLEQMTTTAENWLKIQPTTPSEPTAIKSQ 865
Query: 3553 LHTREDVIP--SGI-PQAEDRALESL-----------------------RQDWQAYQHRL 3586
L +D + SG+ PQ E ++S+ +Q + Q R
Sbjct: 866 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQARE 925
Query: 3587 SETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHE 3646
E +T F+ + +R E + W++ +E K+S ++ E +L +++
Sbjct: 926 KELQTIFDTLP-PMRYQET-MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 983
Query: 3647 EVTAYRDEVEEVGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3704
+ + + + +E+ + S ++ + + ++ R++ L Q++E + LEE++
Sbjct: 984 SLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQM 1043
Query: 3705 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3764
L + ++ + + W K + D+ ++ K+LK +L+ D++ L
Sbjct: 1044 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG--DSEILKKQLKQCRLLVSDIQTIQPSL 1101
Query: 3765 KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV--RKEHMT--LEKGLHLAKE 3820
S E G++ E A RL E+ + Q + V RKE + LEK + L K+
Sbjct: 1102 NSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKD 1161
Query: 3821 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880
S+ + +TQ EY E + P E + + + K ++ E VK + E
Sbjct: 1162 LSEMHEWMTQAEEEYLERDFEYKTPD----ELQKAVEEMKRAKEEAQQKEAKVKLLTESV 1217
Query: 3881 EALLELVQDVT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKW 3937
+++ V LK +++ L ++YQ LC+ +LE + S L++ KW
Sbjct: 1218 NSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKW 1277
Query: 3938 LLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI-GQCAD 3996
L ++ +L + + + E I++ L + +M ED N +++ TL G D
Sbjct: 1278 LNEVEFKLKTTENIPGGA-EEISEVLDSLENLMRHS---EDNPNQIRILAQTLTDGGVMD 1333
Query: 3997 HL----------------------QAKLKQNVHAHLQGTKD----------------SYS 4018
L Q L+Q++ + + K +Y
Sbjct: 1334 ELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI 1393
Query: 4019 AICSTAQRMYQSLE-------------HELQKHVSRQDTLQQCQAWLSAVQPDLEPSP-- 4063
A A +M Q + E++KH ++ Q+ + + Q L+
Sbjct: 1394 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1453
Query: 4064 ----QPPLSRAEAIKQVK--------HFRAL------QEQARTYLDLLCSMCDLSNASVK 4105
Q P + + +++ K H AL QE ++ L+ C S + VK
Sbjct: 1454 FRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH-CVNLYKSLSEVK 1512
Query: 4106 TTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQDADQQLQNMKR--RH 4160
+ + + +T + I QK Q +N + E + LK +EL + + QQL+ + R
Sbjct: 1513 SEVEMVIKTGRQIVQKK-QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1571
Query: 4161 SELELNIAQNMV----------SQVKDFVKKLQSKQA-----------------SVNTII 4193
E+N+ + S V+ L S+ A S+ +
Sbjct: 1572 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1631
Query: 4194 EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDLQRTRDYHDCMNVVE 4250
E + + K+E+ +++ LN W+ + ++ NL L+ ++ ++ D
Sbjct: 1632 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD------ 1685
Query: 4251 VFLEKFTTEWDNLA-RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
+ K+ + D L S+ + + LK+L L + + ++ +DQ ++ +
Sbjct: 1686 -HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1744
Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIA 4368
++LV+ Q S L R+ + IK K + + LE+ N + E +E +Q N+
Sbjct: 1745 CRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK 1804
Query: 4369 EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALS 4428
E D +++ D+ EL + L+ I D +R+ I+
Sbjct: 1805 EE-------DFNKDMNEDNEGTVKELLQRGDNLQQRITDE---------RKREEIKIKQQ 1848
Query: 4429 DAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD 4488
Q+ N L DL QRRK KAL Q+ QA ++ + + + LP+
Sbjct: 1849 LLQTKHNALKDLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD---IEKKLASLPEP 1902
Query: 4489 -----VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVY 4543
+ + + + + L + + GL G + E T+ + S+ +++ + +
Sbjct: 1903 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 1962
Query: 4544 DSVLQKCSHRLQE-----------LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLM 4592
+ H ++E LE + V + E + L+ ++ P++
Sbjct: 1963 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL-CA 2021
Query: 4593 NESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQF 4652
+ +L Q +NI + + + + L S V+ L E L+ L Q+
Sbjct: 2022 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQW 2081
Query: 4653 NVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEE---- 4708
+ + KD+ + ++ + + I++ Q L+E E QFLR +++P + +
Sbjct: 2082 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQIPENWEHAKYKWY 2140
Query: 4709 ALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQ 4768
LQDG V L +E+ Q+ T +K+ L + + +Q
Sbjct: 2141 LKELQDGIGQRQTVVRTLNATGEEIIQQSS---KTDASILQEKLGSLNLRWQEVCKQLSD 2197
Query: 4769 RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDS 4828
R LE+ + E ++ + L+ N ++P E G Q
Sbjct: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEAD------NIASIPLEP---------GKEQQL 2242
Query: 4829 GIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID 4888
L++V + +E+L PL + Q+ G + + E + E+++ Q+
Sbjct: 2243 KEKLEQVKLLVEEL-----PLR-QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL 2296
Query: 4889 FQTEMSRSLDWLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHK 4947
++SR+L + ++A++ L+ L+D++E++ + + +++ L I N +
Sbjct: 2297 QWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ- 2355
Query: 4948 EKEKFTKAKELISADLEHSLAELSELDGDIQE---ALRTRQATLTEIYSQCQRYYQVFQA 5004
E D+QE A++ +Q + EI S+ Q Y+
Sbjct: 2356 ------------------------EGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE--- 2388
Query: 5005 ANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLI 5063
+ A + +K +E S+E + L+EL + L P +
Sbjct: 2389 ---------------------KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 2427
Query: 5064 KPTGKEDLE------QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5117
G + Q V + E ++ S +++ D+ +A E+ + +
Sbjct: 2428 TTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA-----DFNRAWTELTDWL 2482
Query: 5118 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-KTGNDA 5176
+ ++ + ++ + E + + KA + + ++ L A L+ KT N
Sbjct: 2483 SLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 2541
Query: 5177 SKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPG 5236
++ ++ + + +W ++ Q++ + L + + + T + ++A +++ Q + KL
Sbjct: 2542 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 2601
Query: 5237 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
+ + + +L Q Q+ + + L +L+D +A ++ +
Sbjct: 2602 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA----DDTRKVHM 2657
Query: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQ 5356
IT E + + + + + + +RE ++ET L +
Sbjct: 2658 IT----------ENINASWRSIHKRVSEREAA----------LEETHRLLQ----QFPLD 2693
Query: 5357 LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQD 5415
LE+ LTEA ++ +++ L E + +K + Q QD
Sbjct: 2694 LEKFLAWLTEAETTANVLQDATRKER-----------------LLEDSKGVKELMKQWQD 2736
Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSK 5475
E+E L QK+ + L + D +L LD N K
Sbjct: 2737 LQGEIEAHTDVYHNLDENSQKILRSL---------------EGSDDAVLLQRRLDNMNFK 2781
Query: 5476 LMEL---DAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEY 5532
EL ++ LE + K L + +L + Q +R + + +++
Sbjct: 2782 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSRQAPIGGDFPAVQKQ 2840
Query: 5533 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEA--MTEKL 5590
N++ + ++ + + T+ + + L +E +E+ E A +T L
Sbjct: 2841 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2900
Query: 5591 QYLTSVYCT--EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKK--- 5643
+ T EK++ A+ R+ +E + RLQ LQ+A D+K +AE+ K
Sbjct: 2901 RKQAEEVNTEWEKLNLHSADWQRKIDETLE----RLQELQEATDELDLKLRQAEVIKGSW 2956
Query: 5644 ----------LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSEMESLKPKVQAVQLC 5692
LQ LE+ +A G ++ LKE +SH L ++ +L +QL
Sbjct: 2957 QPVGDLLIDSLQDHLEKVKALR-----GEIAPLKENVSHVNDLARQLTTL-----GIQLS 3006
Query: 5693 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5726
L ED+ L A+ E+ R H A
Sbjct: 3007 PYNLSTLEDLNTRWKLLQVAV---EDRVRQLHEA 3037
Score = 157 bits (397), Expect = 4e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 5520 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 5577
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 383
Query: 5578 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 5636
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 384 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 440
Query: 5637 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 5695
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 441 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 495
Query: 5696 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 5755
L ++ V L H + + E + A+ E+++K L
Sbjct: 496 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 537
Query: 5756 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 5802
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 538 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 597
Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 5856
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 598 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 649
Query: 5857 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5916
L E+S ++IS PS T + + + + Q + P
Sbjct: 650 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 703
Query: 5917 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 5976
Q + + + +L SW T + + + ++ + D +
Sbjct: 704 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 756
Query: 5977 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 6036
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 757 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 795
Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 796 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 839
Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 840 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 899
Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 6216
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 900 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 943
Query: 6217 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 6264
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 944 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1003
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 6295
+ + K +E+ +K S+ E+QM
Sbjct: 1004 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1063
Query: 6296 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6351
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 1064 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1123
Query: 6352 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 6406
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1124 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1183
Query: 6407 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 6462
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1184 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1240
Query: 6463 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 6506
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
Query: 6507 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 6564
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1301 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1344
Query: 6565 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 6624
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1345 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1400
Query: 6625 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 6684
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1401 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1454
Query: 6685 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 6744
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1455 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1513
Query: 6745 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 6801
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1514 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1573
Query: 6802 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 6857
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1574 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1625
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1626 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1685
Query: 6918 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 6977
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1686 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1737
Query: 6978 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 7036
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1738 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1791
Query: 7037 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 7087
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1851
Query: 7088 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 7142
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1852 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1911
Query: 7143 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 7197
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1912 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1966
Query: 7198 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 7256
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2015
Query: 7257 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 7316
A D A +D + L +KDSL + + + A
Sbjct: 2016 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2057
Query: 7317 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 7369
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 2058 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2117
Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 7427
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 2118 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2177
Query: 7428 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7483
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2178 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2234
Query: 7484 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 7540
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2235 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2294
Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2295 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2354
Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 7660
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2355 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2412
Query: 7661 LEEQKKKLAFL--------------------------------------------LKDWE 7676
L+E + K L L D+
Sbjct: 2413 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2472
Query: 7677 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7733
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2473 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2532
Query: 7734 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7793
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2533 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2589
Query: 7794 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 7849
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2590 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2649
Query: 7850 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 7909
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2650 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2707
Query: 7910 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 7962
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2766
Query: 7963 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 8022
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2767 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2824
Query: 8023 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 8063
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2825 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2884
Query: 8064 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8122
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2885 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2940
Query: 8123 WLTEMDLQLTNIE 8135
E+DL+L E
Sbjct: 2941 ---ELDLKLRQAE 2950
Score = 142 bits (359), Expect = 1e-32
Identities = 456/2427 (18%), Positives = 928/2427 (38%), Gaps = 370/2427 (15%)
Query: 3631 RATKE--IQLHQMKKWHEEVT-AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQ 3687
+ TKE QLH + +++T + E + ++ + + S +
Sbjct: 255 KVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFP 314
Query: 3688 ALLLQVLEQIKF----LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743
+ L+ E F +E E+ +L+ +++L W S + + V+ V
Sbjct: 315 SQHLEAPEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVK- 372
Query: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3803
+ T E + D+ + + + G + + + E E E+ + M L
Sbjct: 373 -DQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWEC 429
Query: 3804 VRKEHMTLEKGLH--LAKEFSDKCKALTQWIAEYQEILHVPEEPKM--ELYEKKAQLSKY 3859
+R M + LH L + K K L W+ + +E EE + +L + K Q+ ++
Sbjct: 430 LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 489
Query: 3860 KSLQQTVLSHEPSVKSVR-----------EKGEALLE----------------------L 3886
K LQ+ + + V S+ + A LE L
Sbjct: 490 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549
Query: 3887 VQDVTLK-DKIDQLQSDYQDLCSIGKEHVFSLEAK-VKDHEDYNSELQ-------EVEKW 3937
+QD+ LK ++ + Q + S ++ V + KD + S LQ ++EK
Sbjct: 550 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 608
Query: 3938 LLQMSGRLVA--PDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCA 3995
Q G+L + DLL T +++TQ+ +A ++ A D L K I Q
Sbjct: 609 KKQSMGKLYSLKQDLLSTLKNKSVTQKT---EAWLDNFARCWDNLVQKLEKSTAQISQAV 665
Query: 3996 DHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK---HVSRQDTLQ------ 4046
Q L Q ++ + + + Q + + + EL RQ T+
Sbjct: 666 TTTQPSLTQTT------VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 719
Query: 4047 ------QCQAWLSAVQPDLEPSPQPPLSRAE-----------AIKQVK--HFRALQEQAR 4087
+ +W++ + L+ SP+ + R E AI++ K FR LQ+ +R
Sbjct: 720 LDVDITELHSWITRSEAVLQ-SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASR 778
Query: 4088 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ---GWEEIKHLKSELWI 4144
+ L+ M + A I+Q + + + ++ L W E ++ +
Sbjct: 779 SAQALVEQMVNEG-----VNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYN 833
Query: 4145 YLQDADQQLQNMK-----RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL 4199
LQ +Q + + + E ++ + KD V +L Q + + + L
Sbjct: 834 QLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL 893
Query: 4200 TKKEESPEHKEI------NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4253
+K + P + NH + D+ Q+ LQ D Y + M+ + ++
Sbjct: 894 KEKGQGPMFLDADFVAFTNHFKQVFSDV--QAREKELQTIFDTLPPMRYQETMSAIRTWV 951
Query: 4254 EKFTTEWD--NLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDK 4311
++ T+ L+ +D E L L+ L +LQE++ + L ++M + +
Sbjct: 952 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1011
Query: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL 4371
+ + +E RW +L + Q + +L +Q+ Q L +W E + E
Sbjct: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
Query: 4372 KQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQ 4431
++ + L + S+++ Q L S+ + ++ + ++ L +
Sbjct: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1131
Query: 4432 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4491
+ + + V R++ L L + + + + Q E + + R+ PD++ K
Sbjct: 1132 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQK 1191
Query: 4492 QVKTCKSA-------QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYD 4544
V+ K A +A +K V + AQ + +E ++E L+ L + Y
Sbjct: 1192 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE-------LETLTTNYQ 1244
Query: 4545 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAK 4604
+ + + + + LE+ +KA WL + + N+ + E+ L
Sbjct: 1245 WLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDS 1304
Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY 4664
+N++ S + N + L +T D + E +N FN ++
Sbjct: 1305 LENLMRHSEDNPNQIRILAQT---------LTDGGVMDELINEELETFN-------SRWR 1348
Query: 4665 KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVA 4724
++ E + R++ L+E + QS E E ++E+L+ D A A
Sbjct: 1349 ELHEEAVRRQK---LLEQSIQSAQETEKSL---------HLIQESLTFIDKQLA-----A 1391
Query: 4725 GLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHE 4784
+ + VD +E Q Q D H ++L ++H
Sbjct: 1392 YIADKVDAAQMPQE-----AQKIQSDLTSHEISL-------------------EEMKKHN 1427
Query: 4785 KMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAG---SLQDSGIVLKRVTIHLED 4841
+ + +R L + Q K+ + ++ K +++ A LQ+S ++L V +HL
Sbjct: 1428 QGKEAAQRVLSQIDVAQKKLQDVSM----KFRLFQKPANFEQRLQESKMILDEVKMHL-- 1481
Query: 4842 LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECE------SRMVQSIDFQTEMSR 4895
P L+ + E + +QS L ++ E +E E ++VQ QTE +
Sbjct: 1482 --PALETKSVE--QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK--KQTENPK 1535
Query: 4896 SLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA 4955
LD RV A L L+ ++ K+ +++++ L++ + KE
Sbjct: 1536 ELD--ERVTA-------LKLHYNELG---AKVTERKQQLEKCLKLSRKM---RKEMNVLT 1580
Query: 4956 KELISADLEHSLAELSELDG---DIQEALRTRQATLTEIYSQ---CQRYYQVFQAANDWL 5009
+ L + D+E L + S ++G ++ + +AT EI Q + +V +A L
Sbjct: 1581 EWLAATDME--LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 1638
Query: 5010 EDAQELLQ-----LAGNGLDVES-AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 5063
+ L++ L N + V S AEE L +E+ + F N++ + + D L+
Sbjct: 1639 GKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1698
Query: 5064 ------KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY-QKAREEVIEL 5116
KP KED+ +++ + EL R DS D A D+ +K E I
Sbjct: 1699 DESEKKKPQQKEDVLKRLKA-ELNDIRPKVDSTR--DQAANLMANRGDHCRKLVEPQISE 1755
Query: 5117 MNDTEKKLSEFSLLKTSSS----HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKT 5172
+N +S +KT + E E+ S+ + L+ + + ++ V L+E+ K
Sbjct: 1756 LNHRFAAISH--RIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE--DFNKD 1811
Query: 5173 GNDASKATLSRSM---TTVWQRWT--RLRAVAQDQEKILE------------------DA 5209
N+ ++ T+ + + QR T R R + ++++L+ +
Sbjct: 1812 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 1871
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
+W + + + +D ++ KL S E + ++ + EL++++ L
Sbjct: 1872 SHQWYQYKRQADDLLKCLDDIEKKL-ASLPEPRDERKIKEIDR-------ELQKKKEELN 1923
Query: 5270 MLRQQTLSMLQDGAA----PTPGEEPPLMQEITA--MQDRCLNMQE--KVKTNGKLVKQE 5321
+R+Q + +DGAA PT + +EI + Q R LN + V+ +V E
Sbjct: 1924 AVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE 1983
Query: 5322 LKDREM------VETQINSVKCWVQETKEYLGNPTI---EIDAQLEELQILLTEATNHRQ 5372
E+ T+I V + E ++ L P + + + ++ + L + +Q
Sbjct: 1984 DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQ 2043
Query: 5373 NIEKMAEEQKEKYLGLYTILPSE-LSLQLAEVALDL---KIRDQIQDKIKEVEQSKATSQ 5428
+ ++ +K L + P E + LQ A LD K+ +D+ ++S +
Sbjct: 2044 SSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWR 2103
Query: 5429 ELSRQIQKLAKDLTTILTKLKAKT---DNVVQAKTDQKVLGEELDGCNSK---LMELDAA 5482
I K+ T + KT +N AK + L E DG + + L+A
Sbjct: 2104 RFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKY-KWYLKELQDGIGQRQTVVRTLNAT 2161
Query: 5483 VQKFLEQNGQL-GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILK 5541
++ ++Q+ + L +K+G L Q+ +Q +R +L + + L E+ L +
Sbjct: 2162 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2221
Query: 5542 WIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEK-----LQYLTSV 5596
W+E+A +A + QL+E+ + L+EE L+ + E + S
Sbjct: 2222 WLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISP 2281
Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE------- 5649
+K+ ++ + + ++ + + + ++ KD+ + E +L+ L+ L
Sbjct: 2282 EEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2341
Query: 5650 ------------------QAQATLTSPEVGRLSLKEQLSHRQHLLSE----------MES 5681
Q T + + + ++E LS QHL E +E
Sbjct: 2342 PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED 2401
Query: 5682 LKPKVQAVQLCQSALRIPE-DVVASLPLCHAA----LRLQEEASRLQHTAIQQCNIMQAA 5736
L + +AV LR + D+ L A+ + L + + TAI + + +
Sbjct: 2402 LSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSL 2461
Query: 5737 VVQ---YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQE 5793
+++ + + L + + I+ + V +++++ I + + Q ++ +
Sbjct: 2462 MLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP 2521
Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTE 5820
Q+ L + + L K + +T+
Sbjct: 2522 QLEELITAAQNLKNKTSNQEARTIITD 2548
Score = 134 bits (337), Expect = 4e-30
Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)
Query: 7330 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 7389
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 315 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 371
Query: 7390 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 7441
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 372 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 431
Query: 7442 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 7499
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 432 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 491
Query: 7500 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7555
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 492 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 547
Query: 7556 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7615
++ + +WQR E WL E D V
Sbjct: 548 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 586
Query: 7616 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7675
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 587 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 643
Query: 7676 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7735
+C + LEK ++ AV + LTQ +++
Sbjct: 644 ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 678
Query: 7736 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7795
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 679 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 723
Query: 7796 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 7847
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 724 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 783
Query: 7848 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 7895
E +E I+ ++N RW L++ R+ L+ ++A +QQL++ +
Sbjct: 784 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 843
Query: 7896 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7955
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 844 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 894
Query: 7956 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 8015
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 895 EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 951
Query: 8016 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 8075
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 952 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1011
Query: 8076 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 8134
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
Query: 8135 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 8193
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1131
Query: 8194 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 8248
CQ+V+ R E L + + L D ++ + + E+ D +
Sbjct: 1132 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1183
Query: 8249 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8308
+ L ++ + R++ + A V L+ + S +++A P E
Sbjct: 1184 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1230
Query: 8309 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 8354
+ + + Y L+G LE S + + K L++ F+++ TEN
Sbjct: 1231 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1290
Query: 8355 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 8414
I P G E E S +DS LE+ ++ E++ P + + +
Sbjct: 1291 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1328
Query: 8415 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8462
GV+D RW L +A+ ++ ++Q++Q Q+ TE+
Sbjct: 1329 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1374
Query: 8463 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 8522
L +Q D Q K+ Q + +K + +L S E + + K+ ++
Sbjct: 1375 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1431
Query: 8523 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 8579
RV S ++ + LQD M+ + F + ++ + E+ +D K + +
Sbjct: 1432 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1484
Query: 8580 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 8638
++ +++ E++Q + + L E + V + Q++ + + E E+V +
Sbjct: 1485 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1544
Query: 8639 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 8679
L +V+ ++LEK L +S + L+ W +A +++
Sbjct: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1589
Score = 119 bits (298), Expect = 1e-25
Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)
Query: 521 SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 571
S +++W+ + + S+ QL +E S EQ Y + EM
Sbjct: 945 SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1004
Query: 572 KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 631
KA + + E +W+ LS ++ LEE ++ + N + +L+ W+ +
Sbjct: 1005 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
Query: 632 AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 678
+ L + SE KK R L IQ ++N+ G + + +
Sbjct: 1063 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1122
Query: 679 LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 734
L+ +L LN +W + +V YA+ + + K + V+L +E H+ ++ E
Sbjct: 1123 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1176
Query: 735 LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
LE F ++ +++++ ++ +A+ K++T++ + + ++P
Sbjct: 1177 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1229
Query: 790 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
LK++L + Y L LEE+ L K N+ + +E
Sbjct: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1282
Query: 850 LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 908
FK K T I G++ + + + +L N+++H + Q +I +
Sbjct: 1283 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1328
Query: 909 QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968
++ + + + +ET + ++ E +K+L ++ ++ + E+ L E +
Sbjct: 1329 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1383
Query: 969 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1024
+D++ L A++ D++ QE Q +Q + L + K QG+ + +I
Sbjct: 1384 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1440
Query: 1025 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1083
DV + + ++ + +L + + E+ ++E ++ D+ HL + +E+
Sbjct: 1441 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1491
Query: 1084 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1131
V+ + V + +L E+++ ++ + K E+P + + +
Sbjct: 1492 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1546
Query: 1132 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1188
++E + ++ + QL+ K + E+ E + +TKR + + S L
Sbjct: 1547 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1603
Query: 1189 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1245
+V +++ E +KQ L ++ +AL T+L + E ++ + + I V +
Sbjct: 1604 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1663
Query: 1246 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1292
EE ++ E Q+ E T+ + +A LL ++K KR+ A+ D+
Sbjct: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1723
Query: 1293 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1352
+ ++ + L + RKL + E R ++ R +T K ++
Sbjct: 1724 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1774
Query: 1353 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1411
++ L Q S ++ L E L +E++Q + + + +N + G
Sbjct: 1775 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1829
Query: 1412 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1462
+Q + + K IK+Q+ + + +D+++ K +W + + L +
Sbjct: 1830 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1889
Query: 1463 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1514
+ EK+L +L + +I +I +Q+ + +L+++ GL E+ + A Q
Sbjct: 1890 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1947
Query: 1515 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1568
+ I++K Q RR +RE + E L + + + Q++
Sbjct: 1948 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2007
Query: 1569 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1621
E E L P + +K + ++ +L+ S I TA SA V
Sbjct: 2008 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2066
Query: 1622 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1681
R + + L Q+E + + K+RQ + + W+R ++ F WL E
Sbjct: 2067 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2126
Query: 1682 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1741
++ + + K + L + LQ+ + + + L E + +SK D +++ L
Sbjct: 2127 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2183
Query: 1742 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1801
L+ RW+++ + ++ R L+ +F L F +W L E + I + +
Sbjct: 2184 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2239
Query: 1802 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1852
+ K+ +V+ EL QG L +L G E+ L+ K +
Sbjct: 2240 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2297
Query: 1853 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1910
+ + S+ + +Q + + + + Q L + QL + + + +N+ ++ +
Sbjct: 2298 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2356
Query: 1911 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1967
D + A+++ ++ ILSK Q+ K + Q + + L E + + LL
Sbjct: 2357 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2414
Query: 1968 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2024
+++ LA + + + + + T +L+ P+ L+ L FN+
Sbjct: 2415 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2474
Query: 2025 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2084
EL WL Q+ + +++ +IN + + T + + + + Q L
Sbjct: 2475 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2523
Query: 2085 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2144
+L+ QNLK+ S + A ++I R E +N+ + Q+ L N
Sbjct: 2524 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2566
Query: 2145 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2204
+ L+E+ K +ST +WL+ E+ E+ + + R L W +
Sbjct: 2567 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2607
Query: 2205 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2253
T D I+ Q+A+++ +N+D N L A +LL+++ ++ K + E
Sbjct: 2608 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2665
Query: 2254 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2310
+H +V++ + + ET LQ DL + L E E L+D +T+ E
Sbjct: 2666 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2718
Query: 2311 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
+ + D E +K+ +D+Q E+++ + EN + R
Sbjct: 2719 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2762
Query: 2371 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2422
S + L R + + K + + ++ L+ S + K S+QE W
Sbjct: 2763 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2822
Query: 2423 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2468
+G A K++ + L+ K + + L++V L+ + Q
Sbjct: 2823 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2882
Query: 2469 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
E + L Q V+ +++Q + N E++ ++ + + L ++ +L
Sbjct: 2883 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2942
Query: 2528 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
+L + + E + + + +G+ I ++ + KV+ GE+ +E++ ++ + L+
Sbjct: 2943 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 3000
Query: 2587 EG 2588
G
Sbjct: 3001 LG 3002
Score = 114 bits (286), Expect = 3e-24
Identities = 347/2017 (17%), Positives = 774/2017 (38%), Gaps = 287/2017 (14%)
Query: 3927 YNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMK 3986
Y + L+EV WLL L A + ++ +E + Q H+ M ++ + R+ N+
Sbjct: 340 YQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQL 398
Query: 3987 GDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA---ICSTAQRMYQSLEHELQKHVSRQD 4043
G LIG KL ++ +Q + ++ A QS H + + Q
Sbjct: 399 GSKLIGT------GKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK 452
Query: 4044 TLQQCQAWLSAVQPDLEPSPQPPLSR--AEAIKQVKHFRALQEQARTYLDLLCSMCDLSN 4101
L++ WL+ + + PL + +QV+ + LQE DL +++
Sbjct: 453 -LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE------DLEQEQVRVNS 505
Query: 4102 ASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHS 4161
+ D + Q + L W I + W+ LQD + Q +
Sbjct: 506 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTE--- 562
Query: 4162 ELELNIAQNMVSQVKDFVKKLQSKQ-ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLD 4220
E + +S+ +D V K+ + N ++ + KL + E K
Sbjct: 563 --EQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKK----------- 609
Query: 4221 LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4280
+QS ++DL T E +L+ F WDNL + +STA +A+
Sbjct: 610 --KQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667
Query: 4281 LALALQERKY--AIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQV 4338
+L + + + ++Q +++H +EL ++R ++ I++++ V
Sbjct: 668 TQPSLTQTTVMETVTTVTTREQILVKHAQ---EELPPPPPQ--KKRQITVDSEIRKRLDV 722
Query: 4339 SVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398
+T EL W +EA+ QSP + + S+L+ K
Sbjct: 723 DIT-------------ELHSWITR-----SEAVLQSP-----EFAIFRKEGNFSDLKEKV 759
Query: 4399 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN-------KA 4451
++ + R + D + + ++++ +++ + +D + Q + LN +
Sbjct: 760 NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN-----ADSIKQASEQLNSRWIEFCQL 814
Query: 4452 LSEKTQFLMA---VFQATSQIQQHERKIMFREHICLL-------PDDVSKQVKTCKSAQA 4501
LSE+ +L + +Q+QQ E+ E+ + P + Q+K CK
Sbjct: 815 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 874
Query: 4502 SLKTYQNEVTGLWAQGRELMKEVT----------------EQEKSEVLGKLQELQSVYDS 4545
L Q ++ L Q L ++ +Q S+V + +ELQ+++D+
Sbjct: 875 RLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 934
Query: 4546 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI-VTFPEINLMNESSELHTQLAK 4604
+ ++E W++Q++ ++ P++++ + + +L +
Sbjct: 935 L----------------PPMRYQETMSAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGE 977
Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKF 4663
Q + E ++ L L T + + +E+ Y SE + ++ + + +
Sbjct: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHC 1036
Query: 4664 YKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDE 4722
K++E + ++ + I+ + ++E++ FL+ + P L E L Q CR ++ +
Sbjct: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSD 1093
Query: 4723 VAGLGEAVDELNQKKEGFRSTGQP--------------WQPDKMLHLVTLYHR---LKRQ 4765
+ + +++ +N+ + ++ +P Q D M V Y R LK
Sbjct: 1094 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV--YARKEALKGG 1151
Query: 4766 TEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSL 4825
E+ VSL +D + + HE M Q E L+ ++ + K +E A E++K A
Sbjct: 1152 LEKTVSLQKDLS---EMHEWMTQAEEEYLE--RDFEYKTPDELQKAVEEMKRAKEEA--- 1203
Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
Q +K +T + + P+A E + ++++ + L + + E
Sbjct: 1204 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1263
Query: 4886 SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQE---EIRKIQIHQEEVQSSLRIMN 4942
+ + + ++ WL V+ +L + ++I E + + H E+ + +RI
Sbjct: 1264 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI-- 1321
Query: 4943 ALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVF 5002
L +L + +D I E L T + E++ + R ++
Sbjct: 1322 --------------------LAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLL 1361
Query: 5003 QAANDWLEDAQELLQLAGNGLDV--ESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 5060
+ + ++ ++ L L L + + ++ + +L S +L+
Sbjct: 1362 EQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLE 1421
Query: 5061 PLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR---EEVIELM 5117
+ K ++ Q+V S +Q+ +D + L Q+ Q+++ +EV +
Sbjct: 1422 EMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHL 1481
Query: 5118 NDTEKKLSEFSLLKTSSSH--EAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5175
E K E ++++ +H + LSE K+ V +V +IV ++ + E
Sbjct: 1482 PALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE----- 1536
Query: 5176 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP 5235
L +T + + L A ++++ LE + ++ TE + +L
Sbjct: 1537 -----LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1591
Query: 5236 GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ 5295
SA + + L + + + E+E+Q+ L ++++ + + G++ L++
Sbjct: 1592 KRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL-----KSITEVGEALKTVLGKKETLVE 1646
Query: 5296 E-ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEID 5354
+ ++ + + + + + L+ + K E + ++ + W+ + L +
Sbjct: 1647 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1706
Query: 5355 AQLEE-LQILLTEATNHRQNIEKMAEEQKEKYLG-------LYTILPSELSLQLAEVALD 5406
Q E+ L+ L E + R ++ ++ L SEL+ + A ++
Sbjct: 1707 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHR 1766
Query: 5407 LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ--KV 5464
+K + +KE+EQ + D+ +L L+A+ V K + K
Sbjct: 1767 IKT-GKASIPLKELEQFNS--------------DIQKLLEPLEAEIQQGVNLKEEDFNKD 1811
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQ 5524
+ E+ +G +L++ +Q+ + + + K+ +L + ++ ++ K
Sbjct: 1812 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQ--QLLQTKHNALKDLRSQRRKKAL 1869
Query: 5525 AASHL-EEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSE 5582
SH +Y + +LK ++ K LA S + R++ + KEID E
Sbjct: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLA-------SLPEPRDE--------RKIKEIDRE 1914
Query: 5583 LEAMTEKLQYLT----------SVYCTEKMSQQVAELGRETEE---------LRQMIKIR 5623
L+ E+L + + E Q+++ RE E Q+ +R
Sbjct: 1915 LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVR 1974
Query: 5624 LQNLQDAAKDM--------KKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHL 5675
+ + +DM + E+ + AL + + L +P++ ++ + L
Sbjct: 1975 EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESL 2034
Query: 5676 LSEMESLKP---KVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI 5732
+ +SL+ ++ + ++A V + L A +L + ++ +
Sbjct: 2035 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2094
Query: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS--------NIQELQAQISRHEEL 5784
+V ++ ++ ++K Q + A + + + + ++ELQ I + + +
Sbjct: 2095 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTV 2154
Query: 5785 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 5821
+ + E+I +SK ++ K ++ L EV
Sbjct: 2155 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 2191
Score = 108 bits (269), Expect = 3e-22
Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)
Query: 7255 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 7303
++ ED++ + L+++ N D A +EV +W+ D L+ G + + + F
Sbjct: 318 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 377
Query: 7304 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
HE LG +L ++ + +Q L+ L A ++
Sbjct: 378 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 437
Query: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
Q++L ++D + + L+ L W+ + EE + + + +E+LK Q+ +
Sbjct: 438 QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 489
Query: 7404 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 7450
+ DL+ R+N L + + + D+ ++++ L W+ I T +R+
Sbjct: 490 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549
Query: 7451 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 7510
LQ LL+ Q E+ + +L + E + + ++ Q EM S Q
Sbjct: 550 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 598
Query: 7511 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 7570
L + D LE+ + ++LK LLS + Q+ +D+ R W
Sbjct: 599 LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 649
Query: 7571 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 7628
+ +KL K ++S + + L Q + V +E++ ++ +
Sbjct: 650 LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 705
Query: 7629 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
K+ ++ DS L ++ E+ W + S + + + F + E +D EK
Sbjct: 706 KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 758
Query: 7689 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 7748
+ +++ ++ ++L++A S +L++ ++ ++AD I
Sbjct: 759 VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 798
Query: 7749 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7808
+E+ L +W E C LS ERLN W + L Q+E + +
Sbjct: 799 QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 847
Query: 7809 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 7859
L I+ + ++ I ++ +L + ++ + +S A + ++
Sbjct: 848 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 907
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 7917
+ ++ + + AR K+L+ + + + MS++RTW+ E++L+ P +
Sbjct: 908 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 966
Query: 7918 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 7977
+ E ++++L E Q LQ +++ +G L + + A Q ++
Sbjct: 967 DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1022
Query: 7978 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 8032
RW+ + + +E K+EE +K + + W+ E A S
Sbjct: 1023 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 1078
Query: 8033 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8092
+ K++LK+ + L +N+ +++ E + A L+ + E N +WD++
Sbjct: 1079 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1137
Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 8150
++V + LK + + + + W+T+ + + + E+ + ++Q ++++K
Sbjct: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1197
Query: 8151 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 8210
++E K++ + +I ++ P+ +++EL+ L Q + R
Sbjct: 1198 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1249
Query: 8211 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 8270
L+ + LE+ A WH+ LLS +N L+ + ++
Sbjct: 1250 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1287
Query: 8271 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 8328
+ P + I D +L R E + R L +G + +
Sbjct: 1288 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1347
Query: 8329 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 8388
L + + K L+ S Q+TE + + +D Y+ + + +
Sbjct: 1348 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1407
Query: 8389 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 8447
+++ L E SL + + V+ + ++ AQ +++ MK L QK F
Sbjct: 1408 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1465
Query: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
L L + + L L+ S + + ++ Q+ L K++ K+ + +
Sbjct: 1466 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1523
Query: 8508 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
+ Q E+ ++L +R++ + ++ + + + E + L+ L + + + L L
Sbjct: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583
Query: 8567 ENID---RRKNEIVPIDSNLDAEI 8587
D +++ + + SNLD+E+
Sbjct: 1584 AATDMELTKRSAVEGMPSNLDSEV 1607
Score = 65.9 bits (159), Expect = 2e-09
Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)
Query: 8304 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 8358
PS+ E +DK F + V L +ALE + L A D + Q I +++
Sbjct: 314 PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 373
Query: 8359 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 8411
+ T ++GYM L + ++ +L KL ++EE + +NL ++
Sbjct: 374 QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 425
Query: 8412 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8471
RWE L+ ++ K+ + + L Q N L + WL TEE +++ L
Sbjct: 426 --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 475
Query: 8472 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 8530
D++ ++ Q+++ K LQ+ ++ + + S+ ++ + + L+++L + R
Sbjct: 476 GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 535
Query: 8531 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 8590
W +C E+ LLQD L++ Q E L + N+I E+L
Sbjct: 536 WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 595
Query: 8591 HHKQLMQIKHELLESQLRVASLQDMSCQLL 8620
K L +K +L + + + L + LL
Sbjct: 596 LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 624
Score = 49.3 bits (116), Expect = 2e-04
Identities = 143/807 (17%), Positives = 297/807 (36%), Gaps = 150/807 (18%)
Query: 134 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 193
Q++ L LP Q + + V P P ++ K++ K+ L+W++ +
Sbjct: 2248 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2304
Query: 194 ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 248
KQ IE +KD G+ + ++ + L + N+ N E F + ET
Sbjct: 2305 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2364
Query: 249 ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYP-------DIHNASTDGQEDDEIL-- 299
E+ V +PD + I++ K P + + S++ + + +L
Sbjct: 2365 EIA---------VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 2415
Query: 300 ---------PGFPSFANS--------VQNFKREDRVIFK--------------------- 321
PG + S Q ++ I K
Sbjct: 2416 LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 2475
Query: 322 -EMKVWIEQFERDLTRAQMVESNLQDKYQSF---KHFRVQYEMKRKQIEHLIQPLHR-DG 376
E+ W+ ++ + +++ +L+D + K E +R Q+E LI
Sbjct: 2476 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 2535
Query: 377 KLSLDQAL---------VKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA--- 424
K S +A ++ WD V L + QL++ L WL E A
Sbjct: 2536 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST----QWLEAKEEAEQV 2591
Query: 425 ---LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQ 481
R ++ + T + IQ+K+ + K L ++ R + + + + D
Sbjct: 2592 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL----RQWQTNVDVANDLALKLLRDY 2647
Query: 482 LEDMAERFHFVS-----STSELHLMKME---FLELKYRLLSLLVLAESKLKSWIIKYGRR 533
D + H ++ S +H E LE +RLL L K +W+ +
Sbjct: 2648 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2707
Query: 534 ESVEQLLQNYVSFIENSKF--------------FEQYEVTYQILKQTAEMYVKADGSVEE 579
+V Q +E+SK E + Y L + ++ +++ ++
Sbjct: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2767
Query: 580 AENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQS 639
A + + ++ +W L + ++RS LE W R ++ L WL+ + L++
Sbjct: 2768 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2827
Query: 640 ENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGR----WRELFM 695
DF +Q+ ++ A ++T + ++ L+ + L + +L+
Sbjct: 2828 APIGGDF-----PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2882
Query: 696 EVKQY---AQADEMDRMKKEYTDCVVT----LSAFATEAHKKLSEPLEVSFMNVKLLIQD 748
E ++ +A + R+ ++ + V T L+ + + +K+ E LE +Q+
Sbjct: 2883 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE--------RLQE 2934
Query: 749 LEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLY 808
L++ + + Q ++I K S Q G + ++ E++ ++ +PL
Sbjct: 2935 LQEATDELDLKLRQAEVI--------KGSWQPVGDLLIDSLQDHLEKVKALRGEIAPL-- 2984
Query: 809 ESQQLLIPLEELEKQMTSFYDSLGKIN 835
++ + + +L +Q+T+ L N
Sbjct: 2985 --KENVSHVNDLARQLTTLGIQLSPYN 3009
Score = 35.4 bits (80), Expect = 2.5
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 5939 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5998
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2906 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2965
Query: 5999 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2966 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3020
Query: 6055 STIRMKASGKRQLLEEKLND 6074
+++ + + L E D
Sbjct: 3021 KLLQVAVEDRVRQLHEAHRD 3040
>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
Length = 3685
Score = 313 bits (801), Expect = 6e-84
Identities = 627/3213 (19%), Positives = 1226/3213 (38%), Gaps = 521/3213 (16%)
Query: 24 EQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRM 83
E+E VQK+TFTKW+N+ +K + ++LF D++DG +LL LLE L+GQKLP E+G
Sbjct: 12 EREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST- 69
Query: 84 KRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNLP 143
R+HA+ N+ AL+ L+ + LVNI STDI DG + LGL+W IIL++Q++ + N+
Sbjct: 70 -RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNI- 127
Query: 144 QLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKDF 203
+ Q N++K LL WV+ + + V +F
Sbjct: 128 ----------------------------MAGLQQTNSEKILLSWVRQSTRNYPQVNVINF 159
Query: 204 GKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPRLLDPEDVD 262
SW G+A +++IH+ RP+L D +V +S + LE AF IA +LGI +LLDPEDVD
Sbjct: 160 TTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVD 219
Query: 263 VDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKE 322
PD+KSI+ Y+ + P S + ++ E+LP P +E+
Sbjct: 220 TTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------KEEHFQLHH 270
Query: 323 MKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQ 382
+ +Q L + S+ + +++S+ + + Y H +
Sbjct: 271 QMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL-------E 323
Query: 383 ALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTI 442
A +S+ S L + + LD+ A L + +WL AE L+ + + +
Sbjct: 324 APEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI----SNDVEVV 375
Query: 443 QRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFVSSTSE-LH 499
+ + H+ + + AH+ I + ++ + + D+ ++ E+ + ++S E L
Sbjct: 376 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 435
Query: 500 LMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVEQLLQNYVS 545
+ ME +R+L L + K L W+ K R E +++ +Q +
Sbjct: 436 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495
Query: 546 FIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWRNLSVEVRS 603
E+ EQ +V L + ++ G A E +K + + +W N+
Sbjct: 496 LQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTED 549
Query: 604 VRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDA 663
+L++++ W R AWL + E +N+ HT
Sbjct: 550 RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI-----------------HTTGFKD 592
Query: 664 GNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVV 718
N ++ + ++ + DL KQ + L ++L +K + + + + C
Sbjct: 593 QNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARC-- 650
Query: 719 TLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKES- 777
L + LE S + + + + VM+ + T+ L+
Sbjct: 651 ---------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQE 701
Query: 778 ----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLG 832
P + K S+++++L + E +S + L P + ++ +F D
Sbjct: 702 ELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE 761
Query: 833 KINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTLTLIEKGSQ 877
K+N I + + + AL +Q E + A ++ + + + S+
Sbjct: 762 KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSE 821
Query: 878 SVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK----KFE 933
+ +N++ ++Q + Q+ + + T +++ ++ K +
Sbjct: 822 RLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLS 881
Query: 934 ESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKACDELTDILP 990
+ ++E+ L+I L+EKG L F+ ++V + A K + D LP
Sbjct: 882 GLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 940
Query: 991 EQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTELDR-ETKL 1048
Q A+R W Q E + L + D E +E+ EL ++ L
Sbjct: 941 PMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGELQALQSSL 989
Query: 1049 MPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKEL 1108
Q+ + S K P + K EE+ K+L
Sbjct: 990 QEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI-----------------EGRWKKL 1032
Query: 1109 RAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV-KRAV 1167
+ + +KL E +K + + W++ + LK E E+ K+ +
Sbjct: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGDSEILKKQL 1088
Query: 1168 EEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKM 1227
++ R V+ + ++ L + E + + + + + ++L + K L T + +
Sbjct: 1089 KQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQ 1144
Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF------------------ 1269
+ KE +K LE+ +S K++ E E + E +
Sbjct: 1145 V------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1198
Query: 1270 EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRE 1329
E ++ QQK ++ V IAQA P E L+K TL
Sbjct: 1199 EMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL-------- 1243
Query: 1330 RQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRT 1389
T +W N + + L + + LS+ LE + L + + K T
Sbjct: 1244 -------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNEVEFKLKTT 1292
Query: 1390 ESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWD 1449
E+I AE E SE+ +N L + ++ Q++ L TL + E++ + +
Sbjct: 1293 ENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMDELINEELE 1345
Query: 1450 HFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQS 1509
F S + L ++K L S+ + + I+ ++ I+ +L++ + + +A
Sbjct: 1346 TFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQ 1405
Query: 1510 FAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEENLR---KI 1564
Q E+ +I++ LT EE+++H Q E +L + QK +++ ++
Sbjct: 1406 MPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRL 1460
Query: 1565 QQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQALESLSSAIT 1610
Q + FE +L +K+ A ET V QE ++L ++L + S +
Sbjct: 1461 FQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVE 1520
Query: 1611 AFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKEL 1664
+ R++V N + AL+ Y ++ + ER+ LE L +++ KE+
Sbjct: 1521 MVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEM 1580
Query: 1665 SSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLF 1724
+ WL + + + + ++ E+ +A Q E+ Q + ++ E+L
Sbjct: 1581 NVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALK 1639
Query: 1725 SVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLF 1784
+V K + +++ L L+ W + + +N L + FD+ + + WI
Sbjct: 1640 TVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1698
Query: 1785 LSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1844
+ L + + + L R K AE+ + ++ S + A +L+
Sbjct: 1699 DTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA-----------NLMAN 1744
Query: 1845 KAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQLRQTVEAT 1894
+ + C +L E + R A+SH L E Q ++ + +L L E
Sbjct: 1745 RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLE--AEIQ 1802
Query: 1895 NSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQ 1954
+N E D KD+N+ N ++ D + +I +R +
Sbjct: 1803 QGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKREEIKIKQQL 1853
Query: 1955 LCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQAL 2014
L + +++L ++ +A ++ ++ Q ++LLK ++DIE++ L EP +
Sbjct: 1854 LQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASLPEPRDE-- 1909
Query: 2015 QQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPE-----VDREINRLEVTWDD 2069
R +++ EL + EL ++ +A+ +++ A A E + + +E +
Sbjct: 1910 ----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1965
Query: 2070 TKRL----IHENQGQCCGLI--DLMREYQNLKSAVSKVLENASSVIVTRTTI-------- 2115
+RL IH + + ++ D+ E + S + + S ++ +
Sbjct: 1966 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2025
Query: 2116 KDQEDLKWAFSKHETAKNKMNYKQKD---LDNFTSKGKHLLSELKKIHSSDFSLVKTDME 2172
KD EDL F + E+ KN + Q+ +D SK L + + ++
Sbjct: 2026 KDFEDL---FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLD 2082
Query: 2173 STVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE-NISNLDNHL 2231
+W V++ ++ R S+ W W + + I H
Sbjct: 2083 F---QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 2139
Query: 2232 RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL------ETPPDLQFIEADLMQKL 2285
+ + LKE + + + + L++ ++ + + E L ++ ++L
Sbjct: 2140 KYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2199
Query: 2286 EHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE----SLMNCAQNETCEALKK 2341
K+ E K L +F ++ +N+ W + + L + + E L++
Sbjct: 2200 SDRKKRLEEQKNILSEF-------QRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2252
Query: 2342 VKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELES-LGRAMTGLIKKHEAVSQL 2395
VK + +EL +Q + E +++ +LE+ L + IK A+ +
Sbjct: 2253 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEK 2312
Query: 2396 CSKTQASLQE--SLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2453
+ +A +++ LEK + ++ L + + + D+Q
Sbjct: 2313 QGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETE 2369
Query: 2454 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQ-D 2512
+V Q ++ + +GQ LY K ++ ++ + E++A + + L++ +A Q D
Sbjct: 2370 IAVQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPD 2426
Query: 2513 CASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL---- 2568
A L + T+ + Q + K+ + K+EM +L
Sbjct: 2427 LAPGLTTIGAS---------------PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2471
Query: 2569 ------AARESLDKLSQRGQLLSEEGHGAG--------------------QEGRLCSQLL 2602
A E D LS Q++ + G Q +L+
Sbjct: 2472 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2531
Query: 2603 TSHQNLLRMTK------------EKLRSCQVALQEH-----EALEEALQSMWFWVKAIQD 2645
T+ QNL T E++++ +QEH + L E L+ W++A ++
Sbjct: 2532 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2591
Query: 2646 RLACAESTLG--------------SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQA 2691
AE LG + D ++K++++ + + + + +++A +
Sbjct: 2592 ----AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKL 2647
Query: 2692 LRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMES 2751
LR + + R + E + W I ++ LE + + W+
Sbjct: 2648 LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 2707
Query: 2752 VD---------QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE 2802
+ + E L+ G+KE L+ Q + E E HT H L S+++
Sbjct: 2708 AETTANVLQDATRKERLLEDSKGVKE---LMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2764
Query: 2803 KTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL---------MYLDAVHEFT 2853
E Q L D M ++RK ++ HL ++L ++ E
Sbjct: 2765 SLEGSDDAVLLQRRL-----DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL-SLQELL 2818
Query: 2854 DWLHSAKEELHRWSDMSGDSSATQKKLS---------KIKELIDSREIGASRLSRVE--- 2901
WL +EL R + + GD A QK+ K KE + + R+ E
Sbjct: 2819 VWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL 2878
Query: 2902 -----------SLAPEVK-QNTT---ASGCELMHTEMQALRADWKQWEDSVFQTQSCLEN 2946
L PE + QN T E ++TE + L W+ + +T LE
Sbjct: 2879 EGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDET---LER 2935
Query: 2947 LVSQMALSEQEFSGQVAQLEQALEQFSALLKTW 2979
L QE +L+ L Q + +W
Sbjct: 2936 L--------QELQEATDELDLKLRQAEVIKGSW 2960
Score = 215 bits (547), Expect = 2e-54
Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)
Query: 6732 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6791
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 774 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 824
Query: 6792 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6848
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 825 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 876
Query: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 877 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 935
Query: 6907 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6963
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 936 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 992
Query: 6964 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 7022
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 993 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1048
Query: 7023 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7081
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 1049 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1108
Query: 7082 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7141
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 1109 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1168
Query: 7142 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7201
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1169 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1228
Query: 7202 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7261
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1229 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1288
Query: 7262 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7321
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1289 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1338
Query: 7322 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1397
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7436
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1398 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1457
Query: 7437 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7496
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1458 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1503
Query: 7497 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7554
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1504 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1562
Query: 7555 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1563 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1620
Query: 7613 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7672
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1621 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1678
Query: 7673 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7723
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1679 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1733
Query: 7724 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7783
D L + + IS LN R + + H++ + I L E
Sbjct: 1734 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1784
Query: 7784 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7843
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1785 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1834
Query: 7844 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7902
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1835 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1894
Query: 7903 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7961
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1895 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1942
Query: 7962 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 8003
E IQ L +RWR I + RRL EET + +
Sbjct: 1943 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1997
Query: 8004 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 8057
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2053
Query: 8058 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 2054 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2113
Query: 8118 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 8176
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 2114 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2172
Query: 8177 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 8234
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2232
Query: 8235 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8291
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2291
Query: 8292 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 8338
L+ +SRALP E Q + + ++ L LE Q+ L
Sbjct: 2292 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2347
Query: 8339 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 8381
+ + F +Q+TE +++K P E+ + + + L + S
Sbjct: 2348 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2407
Query: 8382 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 8440
S +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK L M +L
Sbjct: 2408 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2466
Query: 8441 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 8498
+D N W L D L+Q+ + + + D++ I I K K + ++ R+
Sbjct: 2467 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2526
Query: 8499 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 8552
+ + + + ++E+R + DR+ ++ +WD V L+ R +L+D+
Sbjct: 2527 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2586
Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
+ E L ++ K +D+ +Q + Q+ +L + Q V
Sbjct: 2587 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2640
Query: 8613 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8661
D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2641 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2685
Score = 195 bits (496), Expect = 1e-48
Identities = 525/2901 (18%), Positives = 1111/2901 (38%), Gaps = 392/2901 (13%)
Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
+L + L ++ ++ W+ E+ + GE + K++ H E ++ +L
Sbjct: 333 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 390
Query: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2626
A + + + Q G L G + E + NLL E LR + Q H
Sbjct: 391 AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 446
Query: 2627 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2679
L + L+ + W+ ++R E D LE Q+Q +++ + E V
Sbjct: 447 RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 505
Query: 2680 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2739
++N SS ++ QL+ L + WA+I + L+ ++ +W
Sbjct: 506 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
Query: 2740 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2796
E + W+ + + G K++ +L LQ + ++ E +++ +L +
Sbjct: 566 EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 623
Query: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
++L +++S ++ + ++ ++K+E+ + + + +
Sbjct: 624 KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 669
Query: 2857 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916
+ + L + + M ++ T ++ +K + + R ++ E+++
Sbjct: 670 TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 729
Query: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976
EL H+ + A + E ++F+ + +L ++ E+E + + +L+ A AL+
Sbjct: 730 EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 788
Query: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
+ EG N D + +E L S+ E C+ + +
Sbjct: 789 EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 825
Query: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
+ +I YN L Q L+Q A + WL T P
Sbjct: 826 LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 862
Query: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3153
+ + + L+ ++ ++ Q ++ + + ++ KEK +G + A A
Sbjct: 863 PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 917
Query: 3154 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3209
+K S++ +E L+ + + ++ + I+ W+ S+T+ + + S Y++ +
Sbjct: 918 FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 977
Query: 3210 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3264
R E Q LQS L+E ++ + + +KA S+ ++ ++ ++ L
Sbjct: 978 RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1032
Query: 3265 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
S+ E +L+ + + + I+ L+ WM + L D +L + +
Sbjct: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1092
Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3384
L+S Q + + + G+ + PE ++ +L+ + W + K L
Sbjct: 1093 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1152
Query: 3385 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3427
+G L K S Q + + WM D ++ + E +R E + K
Sbjct: 1153 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1211
Query: 3428 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487
K KLL E V S + A + EL+ L Y+ + R
Sbjct: 1212 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1261
Query: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3547
E++ E L+ WL + + KL + G A L L+ L H +
Sbjct: 1262 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1321
Query: 3548 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY-------QHRLSETRTQFNNVVNKL 3600
+ + T D + + + LE+ W+ Q L ++ L
Sbjct: 1322 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1379
Query: 3601 RLMEQKFQQVDEWLKT-------AEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
L+++ +D+ L A + + QS+ + EI L +MKK ++ A +
Sbjct: 1380 HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1439
Query: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
+ ++ AQ+ L + + R+ + R Q + +L+++K +++ +
Sbjct: 1440 VLSQIDV-AQKKLQDVSMKFRLFQKPANFEQRLQESKM-ILDEVKMHLPALETKSVEQEV 1497
Query: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
+ S + + +K+ V ++++ V +KT G +
Sbjct: 1498 VQSQLNHCVNLYKSLSEVKSEVEMV--------IKT---------------------GRQ 1528
Query: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833
V+ + + L + + EL + V + LEK L L+++ + LT+W+A
Sbjct: 1529 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1588
Query: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVT 3891
L + ++++ K+ Q+ + + +KS+ E GEAL ++ ++
Sbjct: 1589 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1648
Query: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951
++DK+ L S++ + S +E + L K E ++ + + KW++Q A LL
Sbjct: 1649 VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ------ADTLL 1702
Query: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ-------AKLKQ 4004
+ S + Q+ K + E+ ++++ + + L+ DH + ++L
Sbjct: 1703 DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNH 1762
Query: 4005 NVHAHLQGTKDSYSAI--------CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ 4056
A K ++I S Q++ + LE E+Q+ V+ ++ + + +
Sbjct: 1763 RFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKE-----EDFNKDMN 1817
Query: 4057 PDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQ 4116
D E + + L R + ++Q R E+ R + + + + ++ KD++
Sbjct: 1818 EDNEGTVKELLQRGDNLQQ----RITDERKREEIKIKQQLLQTKHNAL----KDLR---- 1865
Query: 4117 TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVK 4176
Q+ +A ++ W + K +L L D +++L ++ E ++K
Sbjct: 1866 --SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE----------RKIK 1913
Query: 4177 DFVKKLQSKQASVNTIIEKVNKLTK------------------KEESPEHKEINHLNDQW 4218
+ ++LQ K+ +N + + L++ +E + + LN
Sbjct: 1914 EIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQ 1973
Query: 4219 LDLCRQSNNLCLQREEDLQ--------RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ R+ + + + L+ T H ++EV E+ D L D E
Sbjct: 1974 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV--EQLLNAPD-LCAKDFED 2030
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4330
E+LK + +LQ+ I+ + +K ++ ++ ++E S L+ +W ++
Sbjct: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2090
Query: 4331 LIK---RKIQVSVTNLEELNVVQSRFQELMEWAEE-----QQPNIAEALKQSPPPDMAQN 4382
+ K + SV + F + + AE+ Q P E K Q+
Sbjct: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2150
Query: 4383 LLMDHLAICSELEA--KQMLLKSLIKDADRVMADLG-LNER-QVIQKALSDAQSHVNCLS 4438
+ + L A ++++ +S DA + LG LN R Q + K LSD + +
Sbjct: 2151 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2210
Query: 4439 DLVGQRRKYLNKAL--SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4496
+++ + ++ LN+ + E+ + ++ + QQ + K+ E + LL +++ +
Sbjct: 2211 NILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL---EQVKLLVEELPLR---- 2263
Query: 4497 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE 4556
Q LK NE G + E EQ+K E KL++ + V + + E
Sbjct: 2264 ---QGILKQL-NETGGPVLVSAPISPE--EQDKLE--NKLKQTNLQWIKVSRALPEKQGE 2315
Query: 4557 LE---KNLVSRKHFKEDFDKACH----WL----KQADIVTFP-----------EINLMNE 4594
+E K+L + ED ++ + WL Q +I P EI + +
Sbjct: 2316 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2375
Query: 4595 SSELHTQLAKYQNILEQSPEYENL---LLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQ 4651
++ L+K Q++ ++ P + + L L + + L E L K L
Sbjct: 2376 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE-----LRAKQPDLAPG 2430
Query: 4652 FNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALS 4711
I A V + ++ ++ S +E+ + + E+ A ++ T+L + LS
Sbjct: 2431 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA-LADFNRAWTELT--DWLS 2487
Query: 4712 LQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTE---- 4767
L D + G E ++E+ K++ + +P ++ L+T LK +T
Sbjct: 2488 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP-QLEELITAAQNLKNKTSNQEA 2546
Query: 4768 -----QRVSLLEDTTSAYQEH-EKMCQQLERQLK------SVKEEQSKVNEETLPAEEKL 4815
R+ +++ QEH + QQL LK KEE +V + E
Sbjct: 2547 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 2606
Query: 4816 KMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD---PLAYEKARHQIQSWQGELKLLTS-- 4870
K ++Q K++ L ++D LA + R ++ ++T
Sbjct: 2607 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 2666
Query: 4871 -----AIGETVTECESRMVQS----IDFQTEMSRSLDWLRRVKAELSGPVYLDL----NL 4917
+I + V+E E+ + ++ F ++ + L WL +AE + V D L
Sbjct: 2667 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERL 2724
Query: 4918 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTK-AKELISAD----LEHSLAELSE 4972
+ + ++++ +++Q + + H E K + L +D L+ L ++
Sbjct: 2725 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2784
Query: 4973 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLE-DAQELLQLAGNGLDVESAEEN 5031
++++ ++ L Q +R + Q WL+ EL + A G D + ++
Sbjct: 2785 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2844
Query: 5032 LKSHMEF---FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL--ELRSQRMS 5086
H F T++ + E + T PL G E L Q+ L E R+Q ++
Sbjct: 2845 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL---EGLEKLYQEPRELPPEERAQNVT 2901
Query: 5087 RDSGAQVDLL----QRCTAQWHDYQKAREEVIELMNDTEK-------KLSEFSLLKTSSS 5135
R Q + + ++ D+Q+ +E +E + + ++ KL + ++K S
Sbjct: 2902 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2961
Query: 5136 -------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTV 5188
++ L + KAL + E + + + A QL G S LS ++ +
Sbjct: 2962 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDL 3020
Query: 5189 WQRWTRLRAVAQDQEKILEDA 5209
RW L+ +D+ + L +A
Sbjct: 3021 NTRWKLLQVAVEDRVRQLHEA 3041
Score = 191 bits (486), Expect = 2e-47
Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 6656
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 396 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 454
Query: 6657 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 6715
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 455 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 514
Query: 6716 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 6761
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 515 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574
Query: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 575 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 631
Query: 6822 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6878
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 632 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691
Query: 6879 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 6935
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 692 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 747
Query: 6936 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 6994
I G + +K + + K + ++S + Q V E +D A
Sbjct: 748 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
Query: 6995 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 7046
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 806 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 855
Query: 7047 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 7104
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 856 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 915
Query: 7105 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7164
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 916 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 973
Query: 7165 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7224
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 974 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1033
Query: 7225 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7284
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 1034 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1089
Query: 7285 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 7341
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 1090 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1146
Query: 7342 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 7401
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1147 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1205
Query: 7402 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 7454
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1206 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1265
Query: 7455 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 7512
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1266 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1321
Query: 7513 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 7572
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1322 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1379
Query: 7573 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 7631
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1380 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1426
Query: 7632 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1427 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1477
Query: 7689 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7746
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1478 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1537
Query: 7747 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 7806
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1538 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1597
Query: 7807 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7860
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1598 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1654
Query: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1655 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1703
Query: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1704 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1745
Query: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 8039
+ C +E ++ SE F + S I T A L
Sbjct: 1746 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1780
Query: 8040 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 8094
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1836
Query: 8095 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 8154
R+T + K +++K QQ
Sbjct: 1837 RITD--------------------------------------------ERKREEIKIKQQ 1852
Query: 8155 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 8214
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1853 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1904
Query: 8215 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8274
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1905 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1960
Query: 8275 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 8334
L + + + + M+ +P E +S S ++
Sbjct: 1961 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 2003
Query: 8335 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 8394
I + +AL +++Q N P+L C+ + + + E L
Sbjct: 2004 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 2038
Query: 8395 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 8434
K ++SL G ++ +HS +T Q+A ++R WE + ++ R
Sbjct: 2039 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2098
Query: 8435 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 8493
++++KW++F+ D+ WL + E+ L + Q E + K LKELQ +
Sbjct: 2099 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2153
Query: 8494 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2154 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2213
Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
F + +L LE D + +P++ + + L++ +Q+ + EL Q + L
Sbjct: 2214 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2270
Query: 8613 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 8659
+ +LV+A E D LE K K + L E+ IK+L +KL
Sbjct: 2271 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2330
Query: 8660 LDVSSSQQDLSSWSS 8674
D+ L W S
Sbjct: 2331 EDLEEQLNHLLLWLS 2345
Score = 187 bits (474), Expect = 5e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 5930 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5988
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 417 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 476
Query: 5989 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 6046
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 477 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 532
Query: 6047 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6104
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 533 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 580
Query: 6105 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6161
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 581 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 640
Query: 6162 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6213
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 641 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 696
Query: 6214 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6259
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 697 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 756
Query: 6260 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6303
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 757 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 816
Query: 6304 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6351
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 817 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 874
Query: 6352 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6385
+ L GL E + QS K + + H +Q D
Sbjct: 875 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 934
Query: 6386 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6431
+SA TW+ E +L + + E E L + L ++E
Sbjct: 935 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 994
Query: 6432 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6483
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 995 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1047
Query: 6484 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6542
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 1048 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1107
Query: 6543 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6596
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 1108 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1167
Query: 6597 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6652
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1168 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1226
Query: 6653 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6706
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1227 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1283
Query: 6707 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6762
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1284 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1333
Query: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1334 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1390
Query: 6823 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6871
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1391 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1450
Query: 6872 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 6914
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1451 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1510
Query: 6915 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 6956
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1511 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1570
Query: 6957 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 6986
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1571 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1630
Query: 6987 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 7033
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1631 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1690
Query: 7034 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 7086
+ W + L + + K Q ED++K + E V+
Sbjct: 1691 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1739
Query: 7087 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 7144
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1740 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1799
Query: 7145 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 7198
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1800 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1854
Query: 7199 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 7258
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1855 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1896
Query: 7259 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 7318
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1897 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1941
Query: 7319 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 7358
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 2001
Query: 7359 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7416
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 2002 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2061
Query: 7417 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7473
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 2062 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2121
Query: 7474 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 7532
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 2122 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2180
Query: 7533 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2181 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2235
Query: 7593 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 7647
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2236 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2295
Query: 7648 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 7704
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2296 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2355
Query: 7705 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 7762
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2356 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2413
Query: 7763 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 7784
L +L ++ + L E A+
Sbjct: 2414 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2473
Query: 7785 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 7838
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2474 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2529
Query: 7839 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 7887
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2530 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2589
Query: 7888 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 7947
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2590 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2641
Query: 7948 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 8007
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2642 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2697
Query: 8008 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 8056
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2698 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2752
Query: 8057 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8115
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2753 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2812
Query: 8116 ARDSILVWLTEMDLQLT 8132
+ +LVWL D +L+
Sbjct: 2813 SLQELLVWLQLKDDELS 2829
Score = 179 bits (453), Expect = 1e-43
Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)
Query: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 6013
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 333 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 392
Query: 6014 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6073
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 393 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
Query: 6074 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6131
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 451 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 498
Query: 6132 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6176
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 499 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 558
Query: 6177 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6236
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 559 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 605
Query: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6295
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 606 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 647
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6355
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 648 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 696
Query: 6356 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 697 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 745
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6462
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 746 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
Query: 6463 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6514
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 806 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 861
Query: 6515 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6570
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 862 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 921
Query: 6571 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6622
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 922 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 981
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6678
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 982 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1041
Query: 6679 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6738
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1097
Query: 6739 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6795
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 1098 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1157
Query: 6796 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6854
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1158 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1215
Query: 6855 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6914
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1216 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1273
Query: 6915 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6974
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1274 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1322
Query: 6975 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 7034
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1323 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1382
Query: 7035 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7085
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1383 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1440
Query: 7086 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7142
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1441 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1479
Query: 7143 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7202
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1480 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1534
Query: 7203 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7262
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1535 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1591
Query: 7263 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7319
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1592 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1645
Query: 7320 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7375
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1646 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1702
Query: 7376 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7429
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1703 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1756
Query: 7430 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7488
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1757 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1814
Query: 7489 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7548
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1815 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1862
Query: 7549 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7608
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1863 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1911
Query: 7609 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7668
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1912 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1969
Query: 7669 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7718
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1970 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2029
Query: 7719 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7765
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 2030 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2089
Query: 7766 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7820
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 2090 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2146
Query: 7821 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7880
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2147 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2206
Query: 7881 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7940
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2207 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2264
Query: 7941 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7995
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2265 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2320
Query: 7996 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 8037
+ +L +K D + WL + F I AK+
Sbjct: 2321 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2380
Query: 8038 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8086
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2439
Query: 8087 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8135
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2440 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2499
Query: 8136 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8194
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2500 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2559
Query: 8195 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8254
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2560 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2619
Query: 8255 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 8310
+ LA+ LR +W + D++ DL + R ++D
Sbjct: 2620 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2662
Query: 8311 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 8363
++ + +S +ALE R L + LD +F + + T N+++ T
Sbjct: 2663 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2722
Query: 8364 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 8417
L+ S K + L GE + D L+ ++ SL G + + + +
Sbjct: 2723 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2782
Query: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477
+W L+ ++L+ ++ + +W++ + L + WL ++EL + + + D
Sbjct: 2783 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2840
Query: 8478 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 8516
++ Q + ++ + ++ +I+S F E
Sbjct: 2841 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2900
Query: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 8576
+R L+ + ++N W+++ +W+ + + L + Q E + L L L + K
Sbjct: 2901 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2960
Query: 8577 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
P+ +L + LQDH +++ ++ E+ + V+ + D++ QL
Sbjct: 2961 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 3002
Score = 179 bits (453), Expect = 1e-43
Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)
Query: 6799 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 6858
RYQ+ +++ WL SA+D L Q + ++E+V+D + + ++ A +
Sbjct: 343 RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 398
Query: 6859 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 6915
+L G++L+ +L + + ++ +++ ++S+W L Q LH++ MD
Sbjct: 399 ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 456
Query: 6916 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 6975
+ E+ W++ E +K E+ + + +Q++K + D+ +Q+ V+ + V+
Sbjct: 457 LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515
Query: 6976 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 7035
+ D S EQL + W + ++ LL+ +L W
Sbjct: 516 VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572
Query: 7036 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 7090
W +E + + H G DQ + ++L+ L+ ++ K++ + K+ +Q+ L+ ++
Sbjct: 573 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 632
Query: 7091 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 7121
NK +S V +T L QT + + +
Sbjct: 633 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 692
Query: 7122 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 7169
+IL+K ++ ++ D +++ + E ++R + S E A+ +
Sbjct: 693 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 752
Query: 7170 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 7218
N +L++ + ER +KF ++ Q++ E +++ +++N
Sbjct: 753 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 810
Query: 7219 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 7275
RW + ++E+L W Y++ + +QQ E T LK
Sbjct: 811 RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 862
Query: 7276 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 7335
+ + ++ C D + L ++ + L LK++ + +D ++ + H
Sbjct: 863 PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 920
Query: 7336 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7393
+ + ++ LQ L + +++ A+ W+ ++E L S +D +++R+
Sbjct: 921 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 979
Query: 7394 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 7447
EL+ L L+ E+ + P ++ K + + W +SSQ E
Sbjct: 980 GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 1039
Query: 7448 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 7505
KL+ + + + +T +++ + + L E G+ + L +Q + L +++
Sbjct: 1040 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1099
Query: 7506 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 7565
+ Q L+S+ GQ++ + + + +L L+ QW + ++ R+ + + +
Sbjct: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159
Query: 7566 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 7623
++ ++ +W+ E YL P LQ+A +E++ ++ +++ L
Sbjct: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1216
Query: 7624 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 7683
E+ ++ A A+ AL+ EL + ++ RL + K L + W + +
Sbjct: 1217 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1276
Query: 7684 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 7741
+ + L FK K ++++P EE+ LEN + D+ Q+ +L TL+
Sbjct: 1277 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1333
Query: 7742 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 7801
D++ +NE +E +W EL H+ ++RRQ++ E+ + A +EK+ L
Sbjct: 1334 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1381
Query: 7802 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 7856
I+E + + K IA +K+ QM + K SHE E++
Sbjct: 1382 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1428
Query: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 7910
K + + Q +L I KKL++ + + K + + L ++ L
Sbjct: 1429 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1487
Query: 7911 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7970
+ S E +Q +LN L + + + + V V+ ++ +
Sbjct: 1488 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1542
Query: 7971 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 8030
+ L + + A ER+ ++E+ +L +K + + +WL +++ S+
Sbjct: 1543 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1602
Query: 8031 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 8085
+ + E+ +A Q+++ + L+ I + L +E + SL
Sbjct: 1603 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1656
Query: 8086 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 8145
N W + R L L + E F+ D I W+ + D L E +
Sbjct: 1657 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1716
Query: 8146 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 8205
+K+LKA +I K++ Q L+ ++E ++ EL + R++
Sbjct: 1717 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1773
Query: 8206 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 8260
+ L D L E E++ L + ++ D + D+ + + +
Sbjct: 1774 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1833
Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 8319
L Q + ER + + + ++ +DL S +AL + Q Y R
Sbjct: 1834 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1884
Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
A L +E ++ L + D+ + I++ + ++ K + +G + G
Sbjct: 1885 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1941
Query: 8380 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 8439
+ + +L + +E E F L+ + T V + ++ + + E+ +
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1999
Query: 8440 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 8499
+ +++ + L + E+ L + D + + Q + LK ++ ++ I
Sbjct: 2000 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 2052
Query: 8500 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 8556
I+ Q+ + R LQ+ LSQ++ +W++V + ++ +G ++ + + FH
Sbjct: 2053 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2112
Query: 8557 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 8615
++ + L E R+ I N + + + K+L + + Q V +L
Sbjct: 2113 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2165
Query: 8616 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 8674
+++ + TD +EK+ + R + + K++S K LE+ ++ S Q+DL+ +
Sbjct: 2166 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2225
Query: 8675 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 8702
+E D S+ G+ ++K + K
Sbjct: 2226 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2254
Score = 179 bits (453), Expect = 1e-43
Identities = 533/2827 (18%), Positives = 1093/2827 (38%), Gaps = 366/2827 (12%)
Query: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5311
H+ ++++L Q +G + Q ++ G + EE + +++ + R CL +
Sbjct: 382 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 440
Query: 5312 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5370
K +N V +L+++++ E + W+ +T+E +E + +L+ L + H
Sbjct: 441 KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 493
Query: 5371 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5426
+ E + +EQ + L ++ E S A AL+ +++ D+ + + E
Sbjct: 494 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 553
Query: 5427 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5486
Q++ + Q+L ++ L K D V + T E+ KL L A ++K
Sbjct: 554 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 612
Query: 5487 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5546
+ +GKL L Q + +N+ S + + L+ + + +++ +EK
Sbjct: 613 ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 660
Query: 5547 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5606
S +Q+ + Q L + T ++ +T+V E++ +
Sbjct: 661 -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 698
Query: 5607 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
A+ EEL + + + ++ K+ + ++ +L + + +++A L SPE +
Sbjct: 699 AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 753
Query: 5667 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5725
S + ++ +E + K + + Q A R + +V + A +++ + +L
Sbjct: 754 GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 811
Query: 5726 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5779
I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S +++Q+
Sbjct: 812 WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 871
Query: 5780 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5839
++ ++ G Q QI L K + + +K K +G LD + +
Sbjct: 872 ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 915
Query: 5840 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5892
+ V R L L P+ + + + S ++ TD +
Sbjct: 916 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
Query: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5950
Q + QAL + + + + ST+ + + E S ++ +++ W+ L +
Sbjct: 976 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1035
Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 6007
+ E + L E + + +K Q+ +Q++ M +++ L E P G S + Q+ + + L+
Sbjct: 1036 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1095
Query: 6008 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 6067
+I +Q +N + +++ +E A+P L++ L L + + + +++
Sbjct: 1096 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151
Query: 6068 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6124
L+ L + Q+ + + +A+E + T L A+ K + Q
Sbjct: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211
Query: 6125 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 6184
+L E V+A + V E L E + T + + L +L +L E+ H
Sbjct: 1212 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKTLEEVWACWH 1269
Query: 6185 DKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 6243
+ ++ + E + L T++ PG E E+ + L
Sbjct: 1270 ELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEVLDS 1308
Query: 6244 QKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 6303
++L+R +I I A+T D G +++++EL + +W LH
Sbjct: 1309 LENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWRELH 1355
Query: 6304 QEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSAVTS 6353
+E +QKLL+ ++ QE Q + ++ L+ K D Q+ + S
Sbjct: 1356 EEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 1415
Query: 6354 LLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLFVAT 6405
L + EE+ + G + I + QK VS + E+RL +
Sbjct: 1416 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESK 1475
Query: 6406 ALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-PENG 6448
+L E ET QE+ L K + E+ E++ Q +
Sbjct: 1476 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1535
Query: 6449 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 6508
+N +++ + L + L + V +R Q+++ L+ + ++ VL LA +
Sbjct: 1536 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1595
Query: 6509 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6568
++ A E + + + KE + + LK +V + L K + + +
Sbjct: 1596 KRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKETLVE 1650
Query: 6569 ELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEKMAG 6611
+ + ++ S S + L L +Y++ ++ AD L EK
Sbjct: 1651 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1710
Query: 6612 DQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6669
QK ++ K E+ + K + M RK++ + +EL +
Sbjct: 1711 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SELNHR 1763
Query: 6670 ASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--NEDR 6724
+A+ R K + L+ L++ ++ + LE +E+ I V L EE N+D
Sbjct: 1764 FAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 1816
Query: 6725 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMS 6784
D + L + Q + + D+ KR I I L+++ N L + K
Sbjct: 1817 NEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1873
Query: 6785 KELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVRDHL 6839
+ H+ W +Y+ ++ DL+ L + +L + + + +EL+ ++ L
Sbjct: 1874 EISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEEL 1926
Query: 6840 NAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSRIDS 6886
NA ++ + + + + S Q RL T+R E + +
Sbjct: 1927 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1986
Query: 6887 QWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6943
+ L ++ +P+ + E H Q A+ EV ++ + + ED K
Sbjct: 1987 EDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQEESL 2038
Query: 6944 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 7003
K I + LQ+ G +IDI + T + LQ S+ VE + E L ++ W
Sbjct: 2039 KNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLDFQW 2085
Query: 7004 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQNAL 7061
+ + + ++ + +E W + +++ W E+ L+ Q + A + L
Sbjct: 2086 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 2145
Query: 7062 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7121
K +L+D I ++ V + G +IQ + +SI+ L L W + +
Sbjct: 2146 K---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 2202
Query: 7122 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 7181
K L+ + S + ++ +L EA +++ L G + ++ +++ ++ L ++L
Sbjct: 2203 KKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELP 2261
Query: 7182 KQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQSSK 7235
++ L++ +L P + L N LK+ N++W L E+ E K
Sbjct: 2262 LRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIK 2321
Query: 7236 ALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ--DCN 7287
L QL ++ +D +Q S ++ Q + N+ + D+ + E+A + D
Sbjct: 2322 DLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQPDVE 2380
Query: 7288 DLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AASAIQ 7323
++L KG K+ L +L + K Q++ A AS Q
Sbjct: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2440
Query: 7324 SDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 7381
+ L ++Q + E A+ K + +SL V F ++ L W+ +++++ Q
Sbjct: 2441 TVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2499
Query: 7382 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQNLN 7434
DL I E + + K M P L+ L L +++E + R++ +
Sbjct: 2500 -VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2558
Query: 7435 RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ 7494
W + R +L L +LE E + L Q KL G Y Q+
Sbjct: 2559 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2618
Query: 7495 RAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7552
+ E Q RQ + + + +LL DD + ++ ++ W+ + +R
Sbjct: 2619 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2678
Query: 7553 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE- 7611
+R ++ R Q++ EK WL E + + ++ R L D KE
Sbjct: 2679 EREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGVKEL 2734
Query: 7612 -KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLE 7662
K + QG Y E +++L S + +A LQ L + KW +
Sbjct: 2735 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2794
Query: 7663 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQMRC 7714
+ L W++ + + L L+ +LS+ P ++H R
Sbjct: 2795 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2854
Query: 7715 KELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELLQRQ 7760
+ + V T + ++ L + L A +++ +L ++ E + +
Sbjct: 2855 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2914
Query: 7761 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEK 7817
WE+L + +++I E L E EL L Q E GD+LI+ + +
Sbjct: 2915 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2974
Query: 7818 LK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 7875
L+ K + EIA +EN + + +L + + L +N RW+ L +
Sbjct: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVED 3033
Query: 7876 RVKKLKE 7882
RV++L E
Sbjct: 3034 RVRQLHE 3040
Score = 176 bits (446), Expect = 9e-43
Identities = 468/2732 (17%), Positives = 1059/2732 (38%), Gaps = 408/2732 (14%)
Query: 1244 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1302
S E+ + E+ E + D + E + L HQ + I Q+ G
Sbjct: 357 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 408
Query: 1303 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1355
G L + E++ L S + L S E+Q R+ + L+ + E N + + +
Sbjct: 409 TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 467
Query: 1356 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1409
+T E L LE L +++Q K + E V+ +L V E+S G
Sbjct: 468 EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 522
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
L++Q K + ++ + E+ ++ + KW S W++EKE +
Sbjct: 523 DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 582
Query: 1470 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527
N + T+ +M S K+ + + + LE++ QS + + + K
Sbjct: 583 NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 634
Query: 1528 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
+ + E L A+C + + QK E++ +I Q+V+ + L T
Sbjct: 635 SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 677
Query: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1646
+T +E++++ T R+ + +E Q K+R
Sbjct: 678 QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 712
Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1706
Q +++ + +RL+ +++ +W+ R EA SPE I + + A++ E
Sbjct: 713 QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 769
Query: 1707 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761
+A + KL S ++ + + +K EQL+ RW + Q++++R+N+L+
Sbjct: 770 --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 827
Query: 1762 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
+++A + QQ +++ + W+K+ + T SE + + Q+ + KD +
Sbjct: 828 YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 882
Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1874
+ +++ L+ L G+ L F++ V+ R+ L + + L
Sbjct: 883 LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 940
Query: 1875 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1930
+ ++S I ++Q T + ++ + +++E+ L + +L+ L +
Sbjct: 941 PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 1000
Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1990
+ + K SE ++ +++ G +++ + L + + + Q+ + L
Sbjct: 1001 TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1060
Query: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2049
K + +++ +E + L+++L+ L ++ + + L + + ++I + +
Sbjct: 1061 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1120
Query: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2109
FA ++ E+ L WD + ++ + G ++ Q S + + + A
Sbjct: 1121 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1180
Query: 2110 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168
+ R K ++L+ A + + AK + K+ + T ++++ + +K
Sbjct: 1181 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1237
Query: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228
++E+ + + +L L + W ++LS ++ W N ++ + +
Sbjct: 1238 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1293
Query: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2288
N E + E ++N E+ +++ L + + +L E +
Sbjct: 1294 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1353
Query: 2289 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347
V + L + + QS Q EK ++ I T +++ L ++ A + +
Sbjct: 1354 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1408
Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
E Q QS+++S + +L + K H+ E+ R ++ + + + + K + + +
Sbjct: 1409 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1465
Query: 2408 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
+F + +QE + K ++ + +V++++L+ N+ S+S+ +S+++ V
Sbjct: 1466 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1523
Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
+ G+ + + + E++T + + + KQ L+ C + L
Sbjct: 1524 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1583
Query: 2528 NLWI----HEMEERFNTENL----------GESKQHIPEKK----NEVHKVEMFLGELLA 2569
W+ E+ +R E + G++ Q EK+ + +V L +L
Sbjct: 1584 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1643
Query: 2570 ARESL--DKLS------------------------------------------QRGQLLS 2585
+E+L DKLS Q LL
Sbjct: 1644 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1703
Query: 2586 EEGHGAGQEGRLCSQLLTSHQNLLR----MTKEKLRSCQVALQEH--EALEEALQSMWFW 2639
E Q+ + L + N +R T+++ + +H + +E + +
Sbjct: 1704 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1763
Query: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAI-------------- 2685
AI R+ ++++ K+ LE+ S IQ LL E E++ + +
Sbjct: 1764 FAAISHRIKTGKASIPLKE-LEQFNSDIQK-LLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1821
Query: 2686 GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES--------VISQWND 2737
G ++ L+ + QR+ + ++ ++ + +A L S + QW
Sbjct: 1822 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1881
Query: 2738 YVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFV------LLDHLQSILSEAEDHTRALH 2791
Y + + L + ++ +++K+ +P+ K K + + L ++ +AE +
Sbjct: 1882 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1941
Query: 2792 RLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2851
+ + ++ + + + F I TV +E M + E + + Y+ + +
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTY- 2000
Query: 2852 FTDWLHSAK-----EELHRWSDM-SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAP 2905
T+ H ++ E+L D+ + D K+ +K + DS + + R+ + S
Sbjct: 2001 LTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 2060
Query: 2906 EVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
Q+ T + + L W++ V++M Q G+ +
Sbjct: 2061 AALQSATPVERVKLQEALSQLDFQWEK---------------VNKMYKDRQ---GRFDRS 2102
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG------QEILDALQKAEPRTEDL 3019
+ +F +K + Q LT E +I E W +E+ D + + + L
Sbjct: 2103 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 2162
Query: 3020 KSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQAS---KGCQNKEQILQQRFRKAFR 3074
+ E+ + S D S K+ L + +C Q S K + ++ IL + F++
Sbjct: 2163 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSE-FQRDLN 2221
Query: 3075 DFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG--ELLS 3132
+F WL A + + P ++ L++++ + E Q L + G L+S
Sbjct: 2222 EFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2280
Query: 3133 TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALE-------NLKIQMKDFEVSAEPI 3185
++ E+ ++ K+ W L +K+ +E L+ +++D E +
Sbjct: 2281 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2340
Query: 3186 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3245
WLS + +Y+ P + +Q + +P + + K Q L++ +
Sbjct: 2341 LLWLSPIRNQL-----EIYNQP-NQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKP 2394
Query: 3246 ASKSFRHRVSQLSSQYLALSNLTKEKVSR-------LDRIVAEHNQ-------------- 3284
A++ + ++ LSS++ A++ L +E ++ L I A Q
Sbjct: 2395 ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 2454
Query: 3285 --------------------FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
F+ EL DW++ ++ S D ++ +K +
Sbjct: 2455 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 2514
Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIRCKSQ 3383
A + +++ Q++ ++T +++ TS + T I +++ +++ W + + Q
Sbjct: 2515 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 2574
Query: 3384 LEGAL---SKWTSYQDGVRQFSG--------W------MDSMEANLNESERQHAELRDKT 3426
L L ++W ++ Q G W +D+++ + E+++ +LR
Sbjct: 2575 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 2634
Query: 3427 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3486
T + A L ++L S +T +V H +T +++ +R+I +R E
Sbjct: 2635 TNVDVANDLALKLLRDYSADDTRKV-------HMIT----ENINASWRSIHKRVSEREAA 2683
Query: 3487 SEKLVRLHQEYQRDLKAFEVWLGQEQ-----------------------EKLDQYSVLEG 3523
E+ RL Q++ DL+ F WL + + E + Q+ L+G
Sbjct: 2684 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2743
Query: 3524 DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQ 3583
+ H +L E Q +L S+ + + V+ R L+++ W +
Sbjct: 2744 EIEAHTDVYHNLDE------NSQKILRSLEGSDDAVL-------LQRRLDNMNFKWSELR 2790
Query: 3584 HRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS---------PRTRRQS--NRA 3632
+ R+ ++ + + Q++ WL+ ++++S P ++Q+ +RA
Sbjct: 2791 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA 2850
Query: 3633 TK-EIQLHQ--MKKWHEEVTAYRDE-----VEEVGARAQEILDE---SHVNSRMGCQATQ 3681
K E++ + + E V + E +E++ +E+ E +V + QA +
Sbjct: 2851 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE 2910
Query: 3682 LTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
+ + ++ L L + + ++E ++ L+E + +
Sbjct: 2911 VNTEWEKLNLHSADWQRKIDETLERLQELQEA 2942
Score = 167 bits (423), Expect = 4e-40
Identities = 525/3002 (17%), Positives = 1145/3002 (38%), Gaps = 438/3002 (14%)
Query: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4195
E+ +L A+ LQ +++E + ++ + ++ L + Q V I++
Sbjct: 350 EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 407
Query: 4196 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4249
KL++ EE+ +++N LN +W + +QSN + + Q+ ++ +D +
Sbjct: 408 GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 467
Query: 4250 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
E + + + E LE LK+ +Q+ K EDL+ Q+ + +L
Sbjct: 468 E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 511
Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4369
+V +++S + LE E+L V+ R+ + W E++
Sbjct: 512 HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 552
Query: 4370 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4429
LL D L L +Q L + + + + + + + + LS
Sbjct: 553 -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 599
Query: 4430 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4488
Q +DL ++++ + K S K Q L++ + S Q+ E + ++ D+
Sbjct: 600 LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 654
Query: 4489 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4548
V K K+ ++ T Q +T E + VT +E+ V +EL
Sbjct: 655 VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 705
Query: 4549 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4607
+ +++ + RK D + W+ +++ ++ PE + + K
Sbjct: 706 PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 765
Query: 4608 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
I + E L R+ Q ++ + N SE+LN+ +F +++ +
Sbjct: 766 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 825
Query: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4722
I + L ++TT + + L+ Q S+ PT A++ L + C+ ++
Sbjct: 826 LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 879
Query: 4723 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4777
++GL ++ L + + GQ P D T + + + E+ + + DT
Sbjct: 880 LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 939
Query: 4778 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4831
+ E M QQ E +L Q V + + E++L +L SLQ+
Sbjct: 940 PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 995
Query: 4832 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4891
L ++ +++++ K + + + +G K L+S + E + E +M + Q
Sbjct: 996 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1055
Query: 4892 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4951
+ W+ V L + + +++++++ ++ ++Q+ +N+++ ++
Sbjct: 1056 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1115
Query: 4952 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 5011
+A+ ++ LE L EL+ + + + R+ L + + ++W+
Sbjct: 1116 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
Query: 5012 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 5068
A+E + + ++ +E K+ E +++ ++ L +++ +I P +
Sbjct: 1176 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1233
Query: 5069 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5128
E L++++ +L Q + + L+ A WH+ E+ + +N+ E F
Sbjct: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1288
Query: 5129 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5183
L T + E++SE V++S + E+ +Q+ T ++
Sbjct: 1289 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1342
Query: 5184 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5243
+ T RW L A ++K+LE ++ + E + + +L A+K
Sbjct: 1343 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1402
Query: 5244 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5303
A++ ++ Q L +S L++ G+E Q + + D
Sbjct: 1403 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAA--QRVLSQIDV 1446
Query: 5304 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE--------IDA 5355
+ V +L ++ E ++ K + E K +L P +E + +
Sbjct: 1447 AQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEVKMHL--PALETKSVEQEVVQS 1500
Query: 5356 QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQD 5415
QL L + + +E + + ++ T P EL ++ + L +++
Sbjct: 1501 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---NELGA 1557
Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG---- 5471
K+ E +Q +LSR+++K +LT+ A TD + ++ + + LD
Sbjct: 1558 KVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1613
Query: 5472 --CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAENRLSK 5521
K +E K + + G+ LGK KL+ L+ I +AE L+
Sbjct: 1614 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNL 1673
Query: 5522 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5581
L + H+E +++ ++ I KWI +A L + Q +E + + L E +I
Sbjct: 1674 LLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELNDIRP 1729
Query: 5582 ELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
++++ ++ L + +C + + Q++EL + IK ++ K++++F
Sbjct: 1730 KVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFN 1787
Query: 5639 AELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV------QAV 5689
++++KL LE Q L + + ++ + LL ++L+ ++ + +
Sbjct: 1788 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1847
Query: 5690 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH 5749
++ Q L+ + + L + +++A + H Q + + E+++
Sbjct: 1848 KIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1902
Query: 5750 L-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL--NSKC 5802
L ++ I+ RE++ K + ++ QA+ + A ++ Q Q++ +
Sbjct: 1903 LPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWREIES 1961
Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE 5862
K + + + TV E E + TED+ E+ PS + + + T +S
Sbjct: 1962 KFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVSQALL 2012
Query: 5863 ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ 5922
E +++P C ++I S+ R+ IH +A+
Sbjct: 2013 E-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKKTAAL 2063
Query: 5923 EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI 5982
+ P L L WE + + ++Q ++E+ +++ ++ + +
Sbjct: 2064 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2123
Query: 5983 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSESCEAD 6036
E L ++ P + EH + LQD I + Q ++ EE++ +S + D
Sbjct: 2124 EQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 2177
Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
+ LQ L L R + + S +++ LEE Q+ L ++ + +E
Sbjct: 2178 AS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDLNEFV 2224
Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
WL L P KE ++ +L + ++ E+ + L +L+ +L+
Sbjct: 2225 LWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2283
Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSPGVQE 6214
+ +E ++L KL++ +++ RAL +KQ ++ ++ + E ++ Q +
Sbjct: 2284 -SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLL 2342
Query: 6215 WLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6271
WL+ R + Q Q +E E + ++ + + S+G+ +
Sbjct: 2343 WLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY------------ 2390
Query: 6272 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 6331
EKP A ++ K E L E+ +LLQ + ++ +
Sbjct: 2391 KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD--------- 2426
Query: 6332 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6391
L G+ G PTQ + VT + A ++ S S+ LE +
Sbjct: 2427 LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADFNRAW 2479
Query: 6392 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6451
T L D L + + +Q ++ D+++++E + K K
Sbjct: 2480 TELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD--------- 2519
Query: 6452 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6511
+ QR Q++E + N +N TS + + II
Sbjct: 2520 --------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII---- 2550
Query: 6512 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6571
++IE IQ D ++E LQ + + E+ K
Sbjct: 2551 --------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK--------- 2580
Query: 6572 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQLLDK 6629
Q L K + E+ L LE+ +E G + K+ E +QL
Sbjct: 2581 --------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQLAKD 2629
Query: 6630 HKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE 6689
+++ ++ L L R + +K + A ++ KR +R LE E
Sbjct: 2630 LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE---E 2686
Query: 6690 TWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLKSSLN 6740
T L + +L + L + + + ++++ ++RL+ + + +Q L+ +
Sbjct: 2687 THRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 2746
Query: 6741 EYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLETILKH 6796
+ + + ++ +++L S+ SD L+ +L+ + W K LE
Sbjct: 2747 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 2806
Query: 6797 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6856
W R +L+ WLQ D L + + + V+ + F +E+ + +
Sbjct: 2807 WKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI 2862
Query: 6857 SSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDLLTNI 6895
S L T L + ++ T LR + ++++W L +
Sbjct: 2863 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 2922
Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
Q K+ + +++L ++ + + L + + K + ++ ++L+K K
Sbjct: 2923 ADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 2980
Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015
+ +I + V VN Q+++ ++ + + + +N W++LQ V ++++
Sbjct: 2981 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVR 3036
Query: 7016 LL 7017
L
Sbjct: 3037 QL 3038
Score = 162 bits (409), Expect = 2e-38
Identities = 468/2591 (18%), Positives = 974/2591 (37%), Gaps = 351/2591 (13%)
Query: 600 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-------NQSENAKKDFFRNLPH 652
E +S S L E N DRY + + +WL AE L N E K F + +
Sbjct: 326 EDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGY 385
Query: 653 WIQQHTAMNDAGNFL--------IETCDEMVSRDLKQQLLLLNGRW---RELFMEVKQYA 701
+ GN L E ++++Q+ LLN RW R ME +
Sbjct: 386 MMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL 445
Query: 702 QADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQ-------DLEDIEQ 754
MD ++ + L+ K EPL ++K +Q DLE +
Sbjct: 446 HRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQV 505
Query: 755 RVPVMDAQYKIITKTAHLITKESPQEEGK---EMFATMSKLKE--------------QLT 797
RV + ++ +++ + +E+ K + +A + + E +LT
Sbjct: 506 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
Query: 798 KVKECYSPLLYESQQLLIPLEELE-KQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 856
+ + +S L E + + + K SL K+ + LE++ QS Q
Sbjct: 566 EEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQ 625
Query: 857 ELLACQENCKKT-----------------LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQR 899
+LL+ +N T + +EK + + + VT + QT +
Sbjct: 626 DLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQTTVME 683
Query: 900 QIADIHVAFQSMVKKTGDW--------KKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 951
+ + Q +VK + K+ + +S + K+ + EL + ++ L+
Sbjct: 684 TVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ 743
Query: 952 EKGDPEELLRRHTEFFSQLDQRVLNAF----------LKACDELTDILPEQ------EQQ 995
PE + R FS L ++V NA L+ L EQ
Sbjct: 744 S---PEFAIFRKEGNFSDLKEKV-NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD 799
Query: 996 GLQEAVRKLHKQWKD---LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQE 1052
+++A +L+ +W + L E L + + L +E+ T + K+ P
Sbjct: 800 SIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTT 859
Query: 1053 GSEKI-IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAA 1111
SE IK D+ RL ++ +L ++ G + L A
Sbjct: 860 PSEPTAIKSQLKICKDE------VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA 913
Query: 1112 IDSTYRKLMEDPDKWKD-------------YTSRFSEFSSWISTNETQLKGIKGEAIDTA 1158
+ ++++ D + Y S +W+ +ET+L + D
Sbjct: 914 FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYE 973
Query: 1159 NHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALV 1218
+ ++ +++ + ++ L +L + +K +++ + ++K E ++ +K L
Sbjct: 974 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1033
Query: 1219 TLLSE----VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENL---FEA 1271
+ L E +E+ ++ + + +K + E+ ++E+ + D+E L +
Sbjct: 1034 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV---DVFLKEEWPALGDSEILKKQLKQ 1090
Query: 1272 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ 1331
+LL+ Q + + Q+I + E R EL++L + D + + +
Sbjct: 1091 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKELNTQWDHMCQQVYAR 1148
Query: 1332 ERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1391
+ ++ L K + + + ++ Q + E +L EL++ E KR +
Sbjct: 1149 KEALKGGLEKTVSLQKDLSEMHEWMTQ---AEEEYLERDFEYKTPDELQKAVEEMKRAKE 1205
Query: 1392 IAVQAENLVKEASE------IPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1445
A Q E VK +E P ++ L+++ +++ + L L KT+E V
Sbjct: 1206 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1265
Query: 1446 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEE 1505
W S E + W+ E E +L E + +I + +E+ +
Sbjct: 1266 ACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE----EISEVLDSLENLMRHSEDNPN 1321
Query: 1506 EAQSFAQFVTTG--ESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1563
+ + AQ +T G I +L EL E A + + + Q+ E++L
Sbjct: 1322 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1381
Query: 1564 IQQSVSEFEDKLAVPI--------------KICSSATE---TYKVLQEHMDLCQALESLS 1606
IQ+S++ + +LA I KI S T + + +++H +A + +
Sbjct: 1382 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVL 1441
Query: 1607 SAITAFSASARKVVNRDSCVQEAAALQQQYED---ILRRAKERQTALENLLAHWQRLEKE 1663
S I + V + Q+ A +Q+ ++ IL K ALE + ++ +
Sbjct: 1442 SQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1501
Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
L+ + + S EM I R Q++Q Q E +
Sbjct: 1502 LNHCVNLYKSLSEVKSEVEMVIKTGR-------QIVQKKQTENPKELD------------ 1542
Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
+ V +KLH +L + + Q + K + + + E E W+
Sbjct: 1543 ------ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE-------WLAA 1589
Query: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
EL S + M + A ++ + E++ + HL + +G A L +
Sbjct: 1590 TDMELTKRSAVEGMPSNL-----DSEVAWGKATQKEIEKQKVHLKSITEVGEA--LKTVL 1642
Query: 1844 GKAEDCFQLFEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVE-ATNSMNKNE 1901
GK E L E+ ++ +A+ S E+L + Q V+ T + + +
Sbjct: 1643 GKKE---TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQAD 1699
Query: 1902 SDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVER 1961
+ L E + Q L+ L+ I K + +Q + A C
Sbjct: 1700 TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD-----STRDQAANLMANRGDHC----- 1749
Query: 1962 IQNLLGTKQSEAD-ALAVLKKAFQDQKEEL-LKSIEDIEERTDKERLKEPTRQALQQRLR 2019
+ L+ + SE + A + + K + LK +E +D ++L EP +QQ +
Sbjct: 1750 -RKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF--NSDIQKLLEPLEAEIQQGVN 1806
Query: 2020 V----FNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRL 2073
+ FN +D +E + L + + Q+ D E+ + L+ + K L
Sbjct: 1807 LKEEDFN--KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1864
Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2133
+ + + + +Y+ + K L++ + + +D+ +K + + K
Sbjct: 1865 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1924
Query: 2134 KMNYKQKDLDNFTSKGKHLLSELKKIHSS----------------DFSLVKTDMESTVDK 2177
++N ++ + + G + E +I S +F+ + T E T+
Sbjct: 1925 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETM-- 1982
Query: 2178 WLDVSEKLEENMDRL-RVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEEL 2236
+ ++E + + + L+ V E+E N P + + ++ + EE
Sbjct: 1983 -MVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN--APDLC--AKDFEDLFKQEES 2037
Query: 2237 LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAK 2296
LK + ++ + R++ +HSK K TP + ++ L Q +++ ++ K
Sbjct: 2038 LKNIKDSLQQSSGRIDIIHSK----KTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2093
Query: 2297 GTLKDFTAQSTQVEKFINDI---TTWFTKVEESLMNCAQNETCEALK---KVKDIQKELQ 2350
F + +F DI W T+ E+ L E E K +K++Q +
Sbjct: 2094 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2153
Query: 2351 SQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL-IKKHEAVSQLCS-KTQASLQESLE 2408
+Q+ + + + ++ + L + L ++ E QL K + Q+++
Sbjct: 2154 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2213
Query: 2409 KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQ 2468
F + EF W A A + G + L+ KL ++ +++ + Q L + +
Sbjct: 2214 SEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNE 2272
Query: 2469 EGQTLY--AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
G + A +S + ++ ++ + N Q +K +AL + E+ +
Sbjct: 2273 TGGPVLVSAPISPEEQDKLENKLKQTN-------LQWIKVSRALPEKQGEIEA------- 2318
Query: 2527 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
++LG+ ++ + + + +++ + ++L + E ++ +Q G +
Sbjct: 2319 ------------QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 2366
Query: 2587 EGHGAGQEGRL-CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2642
E A Q + ++L+ Q+L + T+ R + E +A+ LQ + +A
Sbjct: 2367 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL----RA 2422
Query: 2643 IQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQ 2700
Q LA +T+G+ T + ++ + ++ K KL M ++ AL N+
Sbjct: 2423 KQPDLAPGLTTIGASPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2480
Query: 2701 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2760
+ W ++ + +Q + + N+ + ++ Q +E
Sbjct: 2481 ELTD---------WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE---------- 2521
Query: 2761 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2820
Q +P L+E +L++ S E T R+ E ++ Q
Sbjct: 2522 QRRPQLEELITAAQNLKNKTSNQEARTIITDRI---------------------ERIQNQ 2560
Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
++++ + + +++ E++KD +L+A E L A+ +L W + A QKK+
Sbjct: 2561 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 2620
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
++ K+L + + LA ++ ++ +A +H + + A W+ V +
Sbjct: 2621 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 2680
Query: 2941 QSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVE 2997
++ LE L+ Q L ++F +A L +A E + +L+ ++ LLE +E+++
Sbjct: 2681 EAALEETHRLLQQFPLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMK 2736
Query: 2998 CWHKGQEILDA 3008
W Q ++A
Sbjct: 2737 QWQDLQGEIEA 2747
Score = 159 bits (402), Expect = 1e-37
Identities = 533/2914 (18%), Positives = 1109/2914 (38%), Gaps = 456/2914 (15%)
Query: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3120
+ ++ R++ A + WL++A+ T +I ++ V + ++ + Q +
Sbjct: 336 ESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGR 395
Query: 3121 LNMMLSKGELL--STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDF 3178
+ +L G L + L++++ +Q ++ W+ +K+S L + + +++
Sbjct: 396 VGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQ 455
Query: 3179 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3236
++ + + DWL+KTE+ + DL +R+ Q+ + + E++ + ++N L
Sbjct: 456 KL--KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
Query: 3237 AQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEK-------VSRLDRIVAEHNQFSL 3287
+ E G A+ + ++ L ++ + T+++ + + R+ E FS
Sbjct: 514 VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 573
Query: 3288 GIKELQDWMT--------DAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE--KEIQM 3337
+ E +D + D ML S K+ L+ + + L S+KQ+ ++
Sbjct: 574 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 633
Query: 3338 KMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA--GIRCKSQLEGALSKWTSYQ 3395
K + + E+ L N + +Q+ +S + ++ + + + +E + T Q
Sbjct: 634 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQ 693
Query: 3396 DGVRQFSGWMDSMEANLNESERQHAELRDKT----TMLGKAKLLNEEVL----------- 3440
V+ + +E+R + T L +E VL
Sbjct: 694 ILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 753
Query: 3441 -SYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQER-------AKEAVTKSEKLVR 3492
++S L E + E + +LQD +A+ E+ A SE+L
Sbjct: 754 GNFSDLKEKVNAIEREKAEKF---RKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNS 810
Query: 3493 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3552
E+ + L WL + + Y+ L+ TT + ++Q + S
Sbjct: 811 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQ-QLEQMTTTAENWLKIQPTTPSEPTAIKSQ 869
Query: 3553 LHTREDVIP--SGI-PQAEDRALESL-----------------------RQDWQAYQHRL 3586
L +D + SG+ PQ E ++S+ +Q + Q R
Sbjct: 870 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQARE 929
Query: 3587 SETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHE 3646
E +T F+ + +R E + W++ +E K+S ++ E +L +++
Sbjct: 930 KELQTIFDTLP-PMRYQET-MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 987
Query: 3647 EVTAYRDEVEEVGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3704
+ + + + +E+ + S ++ + + ++ R++ L Q++E + LEE++
Sbjct: 988 SLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQM 1047
Query: 3705 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3764
L + ++ + + W K + D+ ++ K+LK +L+ D++ L
Sbjct: 1048 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG--DSEILKKQLKQCRLLVSDIQTIQPSL 1105
Query: 3765 KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV--RKEHMT--LEKGLHLAKE 3820
S E G++ E A RL E+ + Q + V RKE + LEK + L K+
Sbjct: 1106 NSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKD 1165
Query: 3821 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880
S+ + +TQ EY E + P E + + + K ++ E VK + E
Sbjct: 1166 LSEMHEWMTQAEEEYLERDFEYKTPD----ELQKAVEEMKRAKEEAQQKEAKVKLLTESV 1221
Query: 3881 EALLELVQDVT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKW 3937
+++ V LK +++ L ++YQ LC+ +LE + S L++ KW
Sbjct: 1222 NSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKW 1281
Query: 3938 LLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI-GQCAD 3996
L ++ +L + + + E I++ L + +M ED N +++ TL G D
Sbjct: 1282 LNEVEFKLKTTENIPGGA-EEISEVLDSLENLMRHS---EDNPNQIRILAQTLTDGGVMD 1337
Query: 3997 HL----------------------QAKLKQNVHAHLQGTKD----------------SYS 4018
L Q L+Q++ + + K +Y
Sbjct: 1338 ELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI 1397
Query: 4019 AICSTAQRMYQSLE-------------HELQKHVSRQDTLQQCQAWLSAVQPDLEPSP-- 4063
A A +M Q + E++KH ++ Q+ + + Q L+
Sbjct: 1398 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1457
Query: 4064 ----QPPLSRAEAIKQVK--------HFRAL------QEQARTYLDLLCSMCDLSNASVK 4105
Q P + + +++ K H AL QE ++ L+ C S + VK
Sbjct: 1458 FRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH-CVNLYKSLSEVK 1516
Query: 4106 TTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQDADQQLQNMKR--RH 4160
+ + + +T + I QK Q +N + E + LK +EL + + QQL+ + R
Sbjct: 1517 SEVEMVIKTGRQIVQKK-QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1575
Query: 4161 SELELNIAQNMV----------SQVKDFVKKLQSKQA-----------------SVNTII 4193
E+N+ + S V+ L S+ A S+ +
Sbjct: 1576 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1635
Query: 4194 EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDLQRTRDYHDCMNVVE 4250
E + + K+E+ +++ LN W+ + ++ NL L+ ++ ++ D
Sbjct: 1636 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD------ 1689
Query: 4251 VFLEKFTTEWDNLA-RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
+ K+ + D L S+ + + LK+L L + + ++ +DQ ++ +
Sbjct: 1690 -HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1748
Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIA 4368
++LV+ Q S L R+ + IK K + + LE+ N + E +E +Q N+
Sbjct: 1749 CRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK 1808
Query: 4369 EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALS 4428
E D +++ D+ EL + L+ I D +R+ I+
Sbjct: 1809 EE-------DFNKDMNEDNEGTVKELLQRGDNLQQRITDE---------RKREEIKIKQQ 1852
Query: 4429 DAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD 4488
Q+ N L DL QRRK KAL Q+ QA ++ + + + LP+
Sbjct: 1853 LLQTKHNALKDLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD---IEKKLASLPEP 1906
Query: 4489 -----VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVY 4543
+ + + + + L + + GL G + E T+ + S+ +++ + +
Sbjct: 1907 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 1966
Query: 4544 DSVLQKCSHRLQE-----------LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLM 4592
+ H ++E LE + V + E + L+ ++ P++
Sbjct: 1967 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL-CA 2025
Query: 4593 NESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQF 4652
+ +L Q +NI + + + + L S V+ L E L+ L Q+
Sbjct: 2026 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQW 2085
Query: 4653 NVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEE---- 4708
+ + KD+ + ++ + + I++ Q L+E E QFLR +++P + +
Sbjct: 2086 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQIPENWEHAKYKWY 2144
Query: 4709 ALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQ 4768
LQDG V L +E+ Q+ T +K+ L + + +Q
Sbjct: 2145 LKELQDGIGQRQTVVRTLNATGEEIIQQSS---KTDASILQEKLGSLNLRWQEVCKQLSD 2201
Query: 4769 RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDS 4828
R LE+ + E ++ + L+ N ++P E G Q
Sbjct: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEAD------NIASIPLEP---------GKEQQL 2246
Query: 4829 GIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID 4888
L++V + +E+L PL + Q+ G + + E + E+++ Q+
Sbjct: 2247 KEKLEQVKLLVEEL-----PLR-QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL 2300
Query: 4889 FQTEMSRSLDWLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHK 4947
++SR+L + ++A++ L+ L+D++E++ + + +++ L I N +
Sbjct: 2301 QWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ- 2359
Query: 4948 EKEKFTKAKELISADLEHSLAELSELDGDIQE---ALRTRQATLTEIYSQCQRYYQVFQA 5004
E D+QE A++ +Q + EI S+ Q Y+
Sbjct: 2360 ------------------------EGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE--- 2392
Query: 5005 ANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLI 5063
+ A + +K +E S+E + L+EL + L P +
Sbjct: 2393 ---------------------KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 2431
Query: 5064 KPTGKEDLE------QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5117
G + Q V + E ++ S +++ D+ +A E+ + +
Sbjct: 2432 TTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA-----DFNRAWTELTDWL 2486
Query: 5118 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-KTGNDA 5176
+ ++ + ++ + E + + KA + + ++ L A L+ KT N
Sbjct: 2487 SLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 2545
Query: 5177 SKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPG 5236
++ ++ + + +W ++ Q++ + L + + + T + ++A +++ Q + KL
Sbjct: 2546 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 2605
Query: 5237 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
+ + + +L Q Q+ + + L +L+D +A ++ +
Sbjct: 2606 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA----DDTRKVHM 2661
Query: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQ 5356
IT E + + + + + + +RE ++ET L +
Sbjct: 2662 IT----------ENINASWRSIHKRVSEREAA----------LEETHRLLQ----QFPLD 2697
Query: 5357 LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQD 5415
LE+ LTEA ++ +++ L E + +K + Q QD
Sbjct: 2698 LEKFLAWLTEAETTANVLQDATRKER-----------------LLEDSKGVKELMKQWQD 2740
Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSK 5475
E+E L QK+ + L + D +L LD N K
Sbjct: 2741 LQGEIEAHTDVYHNLDENSQKILRSL---------------EGSDDAVLLQRRLDNMNFK 2785
Query: 5476 LMEL---DAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEY 5532
EL ++ LE + K L + +L + Q +R + + +++
Sbjct: 2786 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSRQAPIGGDFPAVQKQ 2844
Query: 5533 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEA--MTEKL 5590
N++ + ++ + + T+ + + L +E +E+ E A +T L
Sbjct: 2845 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2904
Query: 5591 QYLTSVYCT--EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKK--- 5643
+ T EK++ A+ R+ +E + RLQ LQ+A D+K +AE+ K
Sbjct: 2905 RKQAEEVNTEWEKLNLHSADWQRKIDETLE----RLQELQEATDELDLKLRQAEVIKGSW 2960
Query: 5644 ----------LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSEMESLKPKVQAVQLC 5692
LQ LE+ +A G ++ LKE +SH L ++ +L +QL
Sbjct: 2961 QPVGDLLIDSLQDHLEKVKALR-----GEIAPLKENVSHVNDLARQLTTL-----GIQLS 3010
Query: 5693 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5726
L ED+ L A+ E+ R H A
Sbjct: 3011 PYNLSTLEDLNTRWKLLQVAV---EDRVRQLHEA 3041
Score = 157 bits (397), Expect = 4e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 5520 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 5577
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 387
Query: 5578 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 5636
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 388 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 444
Query: 5637 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 5695
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 445 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 499
Query: 5696 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 5755
L ++ V L H + + E + A+ E+++K L
Sbjct: 500 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 541
Query: 5756 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 5802
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 542 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 601
Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 5856
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 602 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 653
Query: 5857 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5916
L E+S ++IS PS T + + + + Q + P
Sbjct: 654 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 707
Query: 5917 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 5976
Q + + + +L SW T + + + ++ + D +
Sbjct: 708 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 760
Query: 5977 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 6036
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 761 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 799
Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 800 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 843
Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 844 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 903
Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 6216
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 904 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 947
Query: 6217 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 6264
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 948 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1007
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 6295
+ + K +E+ +K S+ E+QM
Sbjct: 1008 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1067
Query: 6296 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6351
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 1068 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1127
Query: 6352 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 6406
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1128 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1187
Query: 6407 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 6462
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1188 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1244
Query: 6463 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 6506
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
Query: 6507 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 6564
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1305 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1348
Query: 6565 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 6624
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1349 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1404
Query: 6625 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 6684
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1405 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1458
Query: 6685 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 6744
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1459 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1517
Query: 6745 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 6801
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1518 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1577
Query: 6802 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 6857
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1578 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1629
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1630 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1689
Query: 6918 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 6977
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1690 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1741
Query: 6978 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 7036
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1742 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1795
Query: 7037 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 7087
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1855
Query: 7088 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 7142
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1856 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1915
Query: 7143 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 7197
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1916 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1970
Query: 7198 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 7256
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2019
Query: 7257 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 7316
A D A +D + L +KDSL + + + A
Sbjct: 2020 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2061
Query: 7317 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 7369
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 2062 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2121
Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 7427
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 2122 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2181
Query: 7428 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7483
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2182 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2238
Query: 7484 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 7540
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2239 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2298
Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2299 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2358
Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 7660
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2359 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2416
Query: 7661 LEEQKKKLAFL--------------------------------------------LKDWE 7676
L+E + K L L D+
Sbjct: 2417 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2476
Query: 7677 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7733
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2477 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2536
Query: 7734 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7793
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2537 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2593
Query: 7794 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 7849
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2594 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2653
Query: 7850 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 7909
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2654 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2711
Query: 7910 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 7962
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2770
Query: 7963 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 8022
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2771 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2828
Query: 8023 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 8063
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2829 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2888
Query: 8064 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8122
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2889 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2944
Query: 8123 WLTEMDLQLTNIE 8135
E+DL+L E
Sbjct: 2945 ---ELDLKLRQAE 2954
Score = 142 bits (359), Expect = 1e-32
Identities = 456/2427 (18%), Positives = 928/2427 (38%), Gaps = 370/2427 (15%)
Query: 3631 RATKE--IQLHQMKKWHEEVT-AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQ 3687
+ TKE QLH + +++T + E + ++ + + S +
Sbjct: 259 KVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFP 318
Query: 3688 ALLLQVLEQIKF----LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743
+ L+ E F +E E+ +L+ +++L W S + + V+ V
Sbjct: 319 SQHLEAPEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVK- 376
Query: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3803
+ T E + D+ + + + G + + + E E E+ + M L
Sbjct: 377 -DQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWEC 433
Query: 3804 VRKEHMTLEKGLH--LAKEFSDKCKALTQWIAEYQEILHVPEEPKM--ELYEKKAQLSKY 3859
+R M + LH L + K K L W+ + +E EE + +L + K Q+ ++
Sbjct: 434 LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 493
Query: 3860 KSLQQTVLSHEPSVKSVR-----------EKGEALLE----------------------L 3886
K LQ+ + + V S+ + A LE L
Sbjct: 494 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 553
Query: 3887 VQDVTLK-DKIDQLQSDYQDLCSIGKEHVFSLEAK-VKDHEDYNSELQ-------EVEKW 3937
+QD+ LK ++ + Q + S ++ V + KD + S LQ ++EK
Sbjct: 554 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 612
Query: 3938 LLQMSGRLVA--PDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCA 3995
Q G+L + DLL T +++TQ+ +A ++ A D L K I Q
Sbjct: 613 KKQSMGKLYSLKQDLLSTLKNKSVTQKT---EAWLDNFARCWDNLVQKLEKSTAQISQAV 669
Query: 3996 DHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK---HVSRQDTLQ------ 4046
Q L Q ++ + + + Q + + + EL RQ T+
Sbjct: 670 TTTQPSLTQTT------VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 723
Query: 4047 ------QCQAWLSAVQPDLEPSPQPPLSRAE-----------AIKQVK--HFRALQEQAR 4087
+ +W++ + L+ SP+ + R E AI++ K FR LQ+ +R
Sbjct: 724 LDVDITELHSWITRSEAVLQ-SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASR 782
Query: 4088 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ---GWEEIKHLKSELWI 4144
+ L+ M + A I+Q + + + ++ L W E ++ +
Sbjct: 783 SAQALVEQMVNEG-----VNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYN 837
Query: 4145 YLQDADQQLQNMK-----RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL 4199
LQ +Q + + + E ++ + KD V +L Q + + + L
Sbjct: 838 QLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL 897
Query: 4200 TKKEESPEHKEI------NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4253
+K + P + NH + D+ Q+ LQ D Y + M+ + ++
Sbjct: 898 KEKGQGPMFLDADFVAFTNHFKQVFSDV--QAREKELQTIFDTLPPMRYQETMSAIRTWV 955
Query: 4254 EKFTTEWD--NLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDK 4311
++ T+ L+ +D E L L+ L +LQE++ + L ++M + +
Sbjct: 956 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1015
Query: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL 4371
+ + +E RW +L + Q + +L +Q+ Q L +W E + E
Sbjct: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
Query: 4372 KQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQ 4431
++ + L + S+++ Q L S+ + ++ + ++ L +
Sbjct: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1135
Query: 4432 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4491
+ + + V R++ L L + + + + Q E + + R+ PD++ K
Sbjct: 1136 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQK 1195
Query: 4492 QVKTCKSA-------QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYD 4544
V+ K A +A +K V + AQ + +E ++E L+ L + Y
Sbjct: 1196 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE-------LETLTTNYQ 1248
Query: 4545 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAK 4604
+ + + + + LE+ +KA WL + + N+ + E+ L
Sbjct: 1249 WLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDS 1308
Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY 4664
+N++ S + N + L +T D + E +N FN ++
Sbjct: 1309 LENLMRHSEDNPNQIRILAQT---------LTDGGVMDELINEELETFN-------SRWR 1352
Query: 4665 KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVA 4724
++ E + R++ L+E + QS E E ++E+L+ D A A
Sbjct: 1353 ELHEEAVRRQK---LLEQSIQSAQETEKSL---------HLIQESLTFIDKQLA-----A 1395
Query: 4725 GLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHE 4784
+ + VD +E Q Q D H ++L ++H
Sbjct: 1396 YIADKVDAAQMPQE-----AQKIQSDLTSHEISL-------------------EEMKKHN 1431
Query: 4785 KMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAG---SLQDSGIVLKRVTIHLED 4841
+ + +R L + Q K+ + ++ K +++ A LQ+S ++L V +HL
Sbjct: 1432 QGKEAAQRVLSQIDVAQKKLQDVSM----KFRLFQKPANFEQRLQESKMILDEVKMHL-- 1485
Query: 4842 LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECE------SRMVQSIDFQTEMSR 4895
P L+ + E + +QS L ++ E +E E ++VQ QTE +
Sbjct: 1486 --PALETKSVE--QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK--KQTENPK 1539
Query: 4896 SLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA 4955
LD RV A L L+ ++ K+ +++++ L++ + KE
Sbjct: 1540 ELD--ERVTA-------LKLHYNELG---AKVTERKQQLEKCLKLSRKM---RKEMNVLT 1584
Query: 4956 KELISADLEHSLAELSELDG---DIQEALRTRQATLTEIYSQ---CQRYYQVFQAANDWL 5009
+ L + D+E L + S ++G ++ + +AT EI Q + +V +A L
Sbjct: 1585 EWLAATDME--LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 1642
Query: 5010 EDAQELLQ-----LAGNGLDVES-AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 5063
+ L++ L N + V S AEE L +E+ + F N++ + + D L+
Sbjct: 1643 GKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1702
Query: 5064 ------KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY-QKAREEVIEL 5116
KP KED+ +++ + EL R DS D A D+ +K E I
Sbjct: 1703 DESEKKKPQQKEDVLKRLKA-ELNDIRPKVDSTR--DQAANLMANRGDHCRKLVEPQISE 1759
Query: 5117 MNDTEKKLSEFSLLKTSSS----HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKT 5172
+N +S +KT + E E+ S+ + L+ + + ++ V L+E+ K
Sbjct: 1760 LNHRFAAISH--RIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE--DFNKD 1815
Query: 5173 GNDASKATLSRSM---TTVWQRWT--RLRAVAQDQEKILE------------------DA 5209
N+ ++ T+ + + QR T R R + ++++L+ +
Sbjct: 1816 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 1875
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
+W + + + +D ++ KL S E + ++ + EL++++ L
Sbjct: 1876 SHQWYQYKRQADDLLKCLDDIEKKL-ASLPEPRDERKIKEIDR-------ELQKKKEELN 1927
Query: 5270 MLRQQTLSMLQDGAA----PTPGEEPPLMQEITA--MQDRCLNMQE--KVKTNGKLVKQE 5321
+R+Q + +DGAA PT + +EI + Q R LN + V+ +V E
Sbjct: 1928 AVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE 1987
Query: 5322 LKDREM------VETQINSVKCWVQETKEYLGNPTI---EIDAQLEELQILLTEATNHRQ 5372
E+ T+I V + E ++ L P + + + ++ + L + +Q
Sbjct: 1988 DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQ 2047
Query: 5373 NIEKMAEEQKEKYLGLYTILPSE-LSLQLAEVALDL---KIRDQIQDKIKEVEQSKATSQ 5428
+ ++ +K L + P E + LQ A LD K+ +D+ ++S +
Sbjct: 2048 SSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWR 2107
Query: 5429 ELSRQIQKLAKDLTTILTKLKAKT---DNVVQAKTDQKVLGEELDGCNSK---LMELDAA 5482
I K+ T + KT +N AK + L E DG + + L+A
Sbjct: 2108 RFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKY-KWYLKELQDGIGQRQTVVRTLNAT 2165
Query: 5483 VQKFLEQNGQL-GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILK 5541
++ ++Q+ + L +K+G L Q+ +Q +R +L + + L E+ L +
Sbjct: 2166 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2225
Query: 5542 WIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEK-----LQYLTSV 5596
W+E+A +A + QL+E+ + L+EE L+ + E + S
Sbjct: 2226 WLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISP 2285
Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE------- 5649
+K+ ++ + + ++ + + + ++ KD+ + E +L+ L+ L
Sbjct: 2286 EEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2345
Query: 5650 ------------------QAQATLTSPEVGRLSLKEQLSHRQHLLSE----------MES 5681
Q T + + + ++E LS QHL E +E
Sbjct: 2346 PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED 2405
Query: 5682 LKPKVQAVQLCQSALRIPE-DVVASLPLCHAA----LRLQEEASRLQHTAIQQCNIMQAA 5736
L + +AV LR + D+ L A+ + L + + TAI + + +
Sbjct: 2406 LSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSL 2465
Query: 5737 VVQ---YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQE 5793
+++ + + L + + I+ + V +++++ I + + Q ++ +
Sbjct: 2466 MLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP 2525
Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTE 5820
Q+ L + + L K + +T+
Sbjct: 2526 QLEELITAAQNLKNKTSNQEARTIITD 2552
Score = 134 bits (337), Expect = 4e-30
Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)
Query: 7330 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 7389
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 319 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 375
Query: 7390 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 7441
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 376 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 435
Query: 7442 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 7499
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 436 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495
Query: 7500 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7555
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 496 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 551
Query: 7556 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7615
++ + +WQR E WL E D V
Sbjct: 552 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 590
Query: 7616 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7675
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 591 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 647
Query: 7676 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7735
+C + LEK ++ AV + LTQ +++
Sbjct: 648 ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 682
Query: 7736 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7795
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 683 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 727
Query: 7796 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 7847
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 728 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 787
Query: 7848 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 7895
E +E I+ ++N RW L++ R+ L+ ++A +QQL++ +
Sbjct: 788 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 847
Query: 7896 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7955
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 848 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 898
Query: 7956 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 8015
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 899 EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 955
Query: 8016 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 8075
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 956 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1015
Query: 8076 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 8134
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
Query: 8135 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 8193
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1135
Query: 8194 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 8248
CQ+V+ R E L + + L D ++ + + E+ D +
Sbjct: 1136 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1187
Query: 8249 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8308
+ L ++ + R++ + A V L+ + S +++A P E
Sbjct: 1188 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1234
Query: 8309 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 8354
+ + + Y L+G LE S + + K L++ F+++ TEN
Sbjct: 1235 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1294
Query: 8355 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 8414
I P G E E S +DS LE+ ++ E++ P + + +
Sbjct: 1295 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1332
Query: 8415 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8462
GV+D RW L +A+ ++ ++Q++Q Q+ TE+
Sbjct: 1333 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1378
Query: 8463 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 8522
L +Q D Q K+ Q + +K + +L S E + + K+ ++
Sbjct: 1379 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1435
Query: 8523 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 8579
RV S ++ + LQD M+ + F + ++ + E+ +D K + +
Sbjct: 1436 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1488
Query: 8580 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 8638
++ +++ E++Q + + L E + V + Q++ + + E E+V +
Sbjct: 1489 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1548
Query: 8639 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 8679
L +V+ ++LEK L +S + L+ W +A +++
Sbjct: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1593
Score = 119 bits (298), Expect = 1e-25
Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)
Query: 521 SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 571
S +++W+ + + S+ QL +E S EQ Y + EM
Sbjct: 949 SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1008
Query: 572 KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 631
KA + + E +W+ LS ++ LEE ++ + N + +L+ W+ +
Sbjct: 1009 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1066
Query: 632 AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 678
+ L + SE KK R L IQ ++N+ G + + +
Sbjct: 1067 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1126
Query: 679 LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 734
L+ +L LN +W + +V YA+ + + K + V+L +E H+ ++ E
Sbjct: 1127 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1180
Query: 735 LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
LE F ++ +++++ ++ +A+ K++T++ + + ++P
Sbjct: 1181 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1233
Query: 790 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
LK++L + Y L LEE+ L K N+ + +E
Sbjct: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1286
Query: 850 LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 908
FK K T I G++ + + + +L N+++H + Q +I +
Sbjct: 1287 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1332
Query: 909 QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968
++ + + + +ET + ++ E +K+L ++ ++ + E+ L E +
Sbjct: 1333 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1387
Query: 969 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1024
+D++ L A++ D++ QE Q +Q + L + K QG+ + +I
Sbjct: 1388 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1444
Query: 1025 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1083
DV + + ++ + +L + + E+ ++E ++ D+ HL + +E+
Sbjct: 1445 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1495
Query: 1084 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1131
V+ + V + +L E+++ ++ + K E+P + + +
Sbjct: 1496 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1550
Query: 1132 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1188
++E + ++ + QL+ K + E+ E + +TKR + + S L
Sbjct: 1551 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1607
Query: 1189 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1245
+V +++ E +KQ L ++ +AL T+L + E ++ + + I V +
Sbjct: 1608 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1667
Query: 1246 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1292
EE ++ E Q+ E T+ + +A LL ++K KR+ A+ D+
Sbjct: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1727
Query: 1293 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1352
+ ++ + L + RKL + E R ++ R +T K ++
Sbjct: 1728 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1778
Query: 1353 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1411
++ L Q S ++ L E L +E++Q + + + +N + G
Sbjct: 1779 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1833
Query: 1412 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1462
+Q + + K IK+Q+ + + +D+++ K +W + + L +
Sbjct: 1834 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1893
Query: 1463 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1514
+ EK+L +L + +I +I +Q+ + +L+++ GL E+ + A Q
Sbjct: 1894 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1951
Query: 1515 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1568
+ I++K Q RR +RE + E L + + + Q++
Sbjct: 1952 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2011
Query: 1569 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1621
E E L P + +K + ++ +L+ S I TA SA V
Sbjct: 2012 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2070
Query: 1622 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1681
R + + L Q+E + + K+RQ + + W+R ++ F WL E
Sbjct: 2071 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2130
Query: 1682 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1741
++ + + K + L + LQ+ + + + L E + +SK D +++ L
Sbjct: 2131 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2187
Query: 1742 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1801
L+ RW+++ + ++ R L+ +F L F +W L E + I + +
Sbjct: 2188 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2243
Query: 1802 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1852
+ K+ +V+ EL QG L +L G E+ L+ K +
Sbjct: 2244 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2301
Query: 1853 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1910
+ + S+ + +Q + + + + Q L + QL + + + +N+ ++ +
Sbjct: 2302 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2360
Query: 1911 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1967
D + A+++ ++ ILSK Q+ K + Q + + L E + + LL
Sbjct: 2361 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2418
Query: 1968 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2024
+++ LA + + + + + T +L+ P+ L+ L FN+
Sbjct: 2419 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2478
Query: 2025 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2084
EL WL Q+ + +++ +IN + + T + + + + Q L
Sbjct: 2479 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2527
Query: 2085 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2144
+L+ QNLK+ S + A ++I R E +N+ + Q+ L N
Sbjct: 2528 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2570
Query: 2145 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2204
+ L+E+ K +ST +WL+ E+ E+ + + R L W +
Sbjct: 2571 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2611
Query: 2205 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2253
T D I+ Q+A+++ +N+D N L A +LL+++ ++ K + E
Sbjct: 2612 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2669
Query: 2254 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2310
+H +V++ + + ET LQ DL + L E E L+D +T+ E
Sbjct: 2670 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2722
Query: 2311 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
+ + D E +K+ +D+Q E+++ + EN + R
Sbjct: 2723 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2766
Query: 2371 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2422
S + L R + + K + + ++ L+ S + K S+QE W
Sbjct: 2767 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2826
Query: 2423 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2468
+G A K++ + L+ K + + L++V L+ + Q
Sbjct: 2827 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2886
Query: 2469 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
E + L Q V+ +++Q + N E++ ++ + + L ++ +L
Sbjct: 2887 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2946
Query: 2528 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
+L + + E + + + +G+ I ++ + KV+ GE+ +E++ ++ + L+
Sbjct: 2947 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 3004
Query: 2587 EG 2588
G
Sbjct: 3005 LG 3006
Score = 114 bits (286), Expect = 3e-24
Identities = 347/2017 (17%), Positives = 774/2017 (38%), Gaps = 287/2017 (14%)
Query: 3927 YNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMK 3986
Y + L+EV WLL L A + ++ +E + Q H+ M ++ + R+ N+
Sbjct: 344 YQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQL 402
Query: 3987 GDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA---ICSTAQRMYQSLEHELQKHVSRQD 4043
G LIG KL ++ +Q + ++ A QS H + + Q
Sbjct: 403 GSKLIGT------GKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK 456
Query: 4044 TLQQCQAWLSAVQPDLEPSPQPPLSR--AEAIKQVKHFRALQEQARTYLDLLCSMCDLSN 4101
L++ WL+ + + PL + +QV+ + LQE DL +++
Sbjct: 457 -LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE------DLEQEQVRVNS 509
Query: 4102 ASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHS 4161
+ D + Q + L W I + W+ LQD + Q +
Sbjct: 510 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTE--- 566
Query: 4162 ELELNIAQNMVSQVKDFVKKLQSKQ-ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLD 4220
E + +S+ +D V K+ + N ++ + KL + E K
Sbjct: 567 --EQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKK----------- 613
Query: 4221 LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4280
+QS ++DL T E +L+ F WDNL + +STA +A+
Sbjct: 614 --KQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671
Query: 4281 LALALQERKY--AIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQV 4338
+L + + + ++Q +++H +EL ++R ++ I++++ V
Sbjct: 672 TQPSLTQTTVMETVTTVTTREQILVKHAQ---EELPPPPPQ--KKRQITVDSEIRKRLDV 726
Query: 4339 SVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398
+T EL W +EA+ QSP + + S+L+ K
Sbjct: 727 DIT-------------ELHSWITR-----SEAVLQSP-----EFAIFRKEGNFSDLKEKV 763
Query: 4399 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN-------KA 4451
++ + R + D + + ++++ +++ + +D + Q + LN +
Sbjct: 764 NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN-----ADSIKQASEQLNSRWIEFCQL 818
Query: 4452 LSEKTQFLMA---VFQATSQIQQHERKIMFREHICLL-------PDDVSKQVKTCKSAQA 4501
LSE+ +L + +Q+QQ E+ E+ + P + Q+K CK
Sbjct: 819 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 878
Query: 4502 SLKTYQNEVTGLWAQGRELMKEVT----------------EQEKSEVLGKLQELQSVYDS 4545
L Q ++ L Q L ++ +Q S+V + +ELQ+++D+
Sbjct: 879 RLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 938
Query: 4546 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI-VTFPEINLMNESSELHTQLAK 4604
+ ++E W++Q++ ++ P++++ + + +L +
Sbjct: 939 L----------------PPMRYQETMSAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGE 981
Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKF 4663
Q + E ++ L L T + + +E+ Y SE + ++ + + +
Sbjct: 982 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHC 1040
Query: 4664 YKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDE 4722
K++E + ++ + I+ + ++E++ FL+ + P L E L Q CR ++ +
Sbjct: 1041 QKLEEQMNKLRKIQNHIQTLKKWMAEVDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSD 1097
Query: 4723 VAGLGEAVDELNQKKEGFRSTGQP--------------WQPDKMLHLVTLYHR---LKRQ 4765
+ + +++ +N+ + ++ +P Q D M V Y R LK
Sbjct: 1098 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV--YARKEALKGG 1155
Query: 4766 TEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSL 4825
E+ VSL +D + + HE M Q E L+ ++ + K +E A E++K A
Sbjct: 1156 LEKTVSLQKDLS---EMHEWMTQAEEEYLE--RDFEYKTPDELQKAVEEMKRAKEEA--- 1207
Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
Q +K +T + + P+A E + ++++ + L + + E
Sbjct: 1208 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1267
Query: 4886 SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQE---EIRKIQIHQEEVQSSLRIMN 4942
+ + + ++ WL V+ +L + ++I E + + H E+ + +RI
Sbjct: 1268 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI-- 1325
Query: 4943 ALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVF 5002
L +L + +D I E L T + E++ + R ++
Sbjct: 1326 --------------------LAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLL 1365
Query: 5003 QAANDWLEDAQELLQLAGNGLDV--ESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 5060
+ + ++ ++ L L L + + ++ + +L S +L+
Sbjct: 1366 EQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLE 1425
Query: 5061 PLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR---EEVIELM 5117
+ K ++ Q+V S +Q+ +D + L Q+ Q+++ +EV +
Sbjct: 1426 EMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHL 1485
Query: 5118 NDTEKKLSEFSLLKTSSSH--EAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5175
E K E ++++ +H + LSE K+ V +V +IV ++ + E
Sbjct: 1486 PALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE----- 1540
Query: 5176 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP 5235
L +T + + L A ++++ LE + ++ TE + +L
Sbjct: 1541 -----LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1595
Query: 5236 GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ 5295
SA + + L + + + E+E+Q+ L ++++ + + G++ L++
Sbjct: 1596 KRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL-----KSITEVGEALKTVLGKKETLVE 1650
Query: 5296 E-ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEID 5354
+ ++ + + + + + L+ + K E + ++ + W+ + L +
Sbjct: 1651 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1710
Query: 5355 AQLEE-LQILLTEATNHRQNIEKMAEEQKEKYLG-------LYTILPSELSLQLAEVALD 5406
Q E+ L+ L E + R ++ ++ L SEL+ + A ++
Sbjct: 1711 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHR 1770
Query: 5407 LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ--KV 5464
+K + +KE+EQ + D+ +L L+A+ V K + K
Sbjct: 1771 IKT-GKASIPLKELEQFNS--------------DIQKLLEPLEAEIQQGVNLKEEDFNKD 1815
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQ 5524
+ E+ +G +L++ +Q+ + + + K+ +L + ++ ++ K
Sbjct: 1816 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQ--QLLQTKHNALKDLRSQRRKKAL 1873
Query: 5525 AASHL-EEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSE 5582
SH +Y + +LK ++ K LA S + R++ + KEID E
Sbjct: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLA-------SLPEPRDE--------RKIKEIDRE 1918
Query: 5583 LEAMTEKLQYLT----------SVYCTEKMSQQVAELGRETEE---------LRQMIKIR 5623
L+ E+L + + E Q+++ RE E Q+ +R
Sbjct: 1919 LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVR 1978
Query: 5624 LQNLQDAAKDM--------KKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHL 5675
+ + +DM + E+ + AL + + L +P++ ++ + L
Sbjct: 1979 EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESL 2038
Query: 5676 LSEMESLKP---KVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI 5732
+ +SL+ ++ + ++A V + L A +L + ++ +
Sbjct: 2039 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2098
Query: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS--------NIQELQAQISRHEEL 5784
+V ++ ++ ++K Q + A + + + + ++ELQ I + + +
Sbjct: 2099 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTV 2158
Query: 5785 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 5821
+ + E+I +SK ++ K ++ L EV
Sbjct: 2159 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 2195
Score = 108 bits (269), Expect = 3e-22
Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)
Query: 7255 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 7303
++ ED++ + L+++ N D A +EV +W+ D L+ G + + + F
Sbjct: 322 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 381
Query: 7304 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
HE LG +L ++ + +Q L+ L A ++
Sbjct: 382 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 441
Query: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
Q++L ++D + + L+ L W+ + EE + + + +E+LK Q+ +
Sbjct: 442 QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 493
Query: 7404 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 7450
+ DL+ R+N L + + + D+ ++++ L W+ I T +R+
Sbjct: 494 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 553
Query: 7451 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 7510
LQ LL+ Q E+ + +L + E + + ++ Q EM S Q
Sbjct: 554 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 602
Query: 7511 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 7570
L + D LE+ + ++LK LLS + Q+ +D+ R W
Sbjct: 603 LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 653
Query: 7571 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 7628
+ +KL K ++S + + L Q + V +E++ ++ +
Sbjct: 654 LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 709
Query: 7629 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
K+ ++ DS L ++ E+ W + S + + + F + E +D EK
Sbjct: 710 KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 762
Query: 7689 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 7748
+ +++ ++ ++L++A S +L++ ++ ++AD I
Sbjct: 763 VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 802
Query: 7749 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7808
+E+ L +W E C LS ERLN W + L Q+E + +
Sbjct: 803 QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 851
Query: 7809 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 7859
L I+ + ++ I ++ +L + ++ + +S A + ++
Sbjct: 852 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 911
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 7917
+ ++ + + AR K+L+ + + + MS++RTW+ E++L+ P +
Sbjct: 912 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 970
Query: 7918 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 7977
+ E ++++L E Q LQ +++ +G L + + A Q ++
Sbjct: 971 DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1026
Query: 7978 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 8032
RW+ + + +E K+EE +K + + W+ E A S
Sbjct: 1027 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 1082
Query: 8033 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8092
+ K++LK+ + L +N+ +++ E + A L+ + E N +WD++
Sbjct: 1083 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1141
Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 8150
++V + LK + + + + W+T+ + + + E+ + ++Q ++++K
Sbjct: 1142 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1201
Query: 8151 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 8210
++E K++ + +I ++ P+ +++EL+ L Q + R
Sbjct: 1202 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1253
Query: 8211 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 8270
L+ + LE+ A WH+ LLS +N L+ + ++
Sbjct: 1254 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1291
Query: 8271 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 8328
+ P + I D +L R E + R L +G + +
Sbjct: 1292 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1351
Query: 8329 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 8388
L + + K L+ S Q+TE + + +D Y+ + + +
Sbjct: 1352 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1411
Query: 8389 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 8447
+++ L E SL + + V+ + ++ AQ +++ MK L QK F
Sbjct: 1412 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1469
Query: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
L L + + L L+ S + + ++ Q+ L K++ K+ + +
Sbjct: 1470 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1527
Query: 8508 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
+ Q E+ ++L +R++ + ++ + + + E + L+ L + + + L L
Sbjct: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587
Query: 8567 ENID---RRKNEIVPIDSNLDAEI 8587
D +++ + + SNLD+E+
Sbjct: 1588 AATDMELTKRSAVEGMPSNLDSEV 1611
Score = 65.9 bits (159), Expect = 2e-09
Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)
Query: 8304 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 8358
PS+ E +DK F + V L +ALE + L A D + Q I +++
Sbjct: 318 PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 377
Query: 8359 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 8411
+ T ++GYM L + ++ +L KL ++EE + +NL ++
Sbjct: 378 QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 429
Query: 8412 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8471
RWE L+ ++ K+ + + L Q N L + WL TEE +++ L
Sbjct: 430 --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 479
Query: 8472 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 8530
D++ ++ Q+++ K LQ+ ++ + + S+ ++ + + L+++L + R
Sbjct: 480 GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 539
Query: 8531 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 8590
W +C E+ LLQD L++ Q E L + N+I E+L
Sbjct: 540 WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 599
Query: 8591 HHKQLMQIKHELLESQLRVASLQDMSCQLL 8620
K L +K +L + + + L + LL
Sbjct: 600 LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 628
Score = 49.3 bits (116), Expect = 2e-04
Identities = 143/807 (17%), Positives = 297/807 (36%), Gaps = 150/807 (18%)
Query: 134 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 193
Q++ L LP Q + + V P P ++ K++ K+ L+W++ +
Sbjct: 2252 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2308
Query: 194 ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 248
KQ IE +KD G+ + ++ + L + N+ N E F + ET
Sbjct: 2309 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2368
Query: 249 ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYP-------DIHNASTDGQEDDEIL-- 299
E+ V +PD + I++ K P + + S++ + + +L
Sbjct: 2369 EIA---------VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 2419
Query: 300 ---------PGFPSFANS--------VQNFKREDRVIFK--------------------- 321
PG + S Q ++ I K
Sbjct: 2420 LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 2479
Query: 322 -EMKVWIEQFERDLTRAQMVESNLQDKYQSF---KHFRVQYEMKRKQIEHLIQPLHR-DG 376
E+ W+ ++ + +++ +L+D + K E +R Q+E LI
Sbjct: 2480 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 2539
Query: 377 KLSLDQAL---------VKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA--- 424
K S +A ++ WD V L + QL++ L WL E A
Sbjct: 2540 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST----QWLEAKEEAEQV 2595
Query: 425 ---LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQ 481
R ++ + T + IQ+K+ + K L ++ R + + + + D
Sbjct: 2596 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL----RQWQTNVDVANDLALKLLRDY 2651
Query: 482 LEDMAERFHFVS-----STSELHLMKME---FLELKYRLLSLLVLAESKLKSWIIKYGRR 533
D + H ++ S +H E LE +RLL L K +W+ +
Sbjct: 2652 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2711
Query: 534 ESVEQLLQNYVSFIENSKF--------------FEQYEVTYQILKQTAEMYVKADGSVEE 579
+V Q +E+SK E + Y L + ++ +++ ++
Sbjct: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2771
Query: 580 AENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQS 639
A + + ++ +W L + ++RS LE W R ++ L WL+ + L++
Sbjct: 2772 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2831
Query: 640 ENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGR----WRELFM 695
DF +Q+ ++ A ++T + ++ L+ + L + +L+
Sbjct: 2832 APIGGDF-----PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2886
Query: 696 EVKQY---AQADEMDRMKKEYTDCVVT----LSAFATEAHKKLSEPLEVSFMNVKLLIQD 748
E ++ +A + R+ ++ + V T L+ + + +K+ E LE +Q+
Sbjct: 2887 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE--------RLQE 2938
Query: 749 LEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLY 808
L++ + + Q ++I K S Q G + ++ E++ ++ +PL
Sbjct: 2939 LQEATDELDLKLRQAEVI--------KGSWQPVGDLLIDSLQDHLEKVKALRGEIAPL-- 2988
Query: 809 ESQQLLIPLEELEKQMTSFYDSLGKIN 835
++ + + +L +Q+T+ L N
Sbjct: 2989 --KENVSHVNDLARQLTTLGIQLSPYN 3013
Score = 35.4 bits (80), Expect = 2.5
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 5939 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5998
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2910 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2969
Query: 5999 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2970 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3024
Query: 6055 STIRMKASGKRQLLEEKLND 6074
+++ + + L E D
Sbjct: 3025 KLLQVAVEDRVRQLHEAHRD 3044
>gi|33624861 spectrin repeat containing, nuclear envelope 2 isoform 2
[Homo sapiens]
Length = 429
Score = 309 bits (791), Expect = 9e-83
Identities = 187/457 (40%), Positives = 260/457 (56%), Gaps = 50/457 (10%)
Query: 8357 RSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 8413
R+ P P T YK G + L + + L ++E+ L G Q
Sbjct: 5 RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------Q 58
Query: 8414 TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELST 8473
+G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL TE ELE L+ + +
Sbjct: 59 QSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS 115
Query: 8474 DIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8533
DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W+
Sbjct: 116 DIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEA 175
Query: 8534 VCSLLEEWRGLLQDALMQCQG--------------FHEMSHGLLLMLENIDRRKNEIVPI 8579
++ WRG L+ +LMQCQG FH++S LLL L + R+ +
Sbjct: 176 AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 235
Query: 8580 DSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIG 8639
D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI
Sbjct: 236 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIE 295
Query: 8640 NRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTP 8699
+LK L ++VS+ + L+ +Q S S DE+D SG P +
Sbjct: 296 KKLKQLREQVSQDLMALQ------GTQNPASPLPSFDEVD-SGDQPPAT----------- 337
Query: 8700 RGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLI 8759
S P P R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+
Sbjct: 338 ------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLL 391
Query: 8760 GLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8796
LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 392 LLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 428
Score = 41.2 bits (95), Expect = 0.046
Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 28/340 (8%)
Query: 5909 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 5968
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 31 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 87
Query: 5969 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 6023
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 88 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 147
Query: 6024 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 6083
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 148 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 206
Query: 6084 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6138
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 207 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 266
Query: 6139 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ--- 6195
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 267 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGTQNPAS 320
Query: 6196 -----EKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 6230
++ +S AT P + RTT ++ S
Sbjct: 321 PLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
Score = 36.2 bits (82), Expect = 1.5
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 7864 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 7918
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 64 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 116
Query: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASV 7946
+EI+ ++ QE+ + + + V SV
Sbjct: 117 IQEIELRVKRLQEILKAFDTYKALVVSV 144
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 296 bits (759), Expect = 5e-79
Identities = 596/3138 (18%), Positives = 1240/3138 (39%), Gaps = 523/3138 (16%)
Query: 13 DIANVMQRLQDEQEIVQKRTFTKWINSHLAKR-KPPMVVDDLFEDMKDGVKLLALLEVLS 71
+ +++++ DE VQK+TFTKWIN+ +K KPP ++D+F D+KDG KLL LLE L+
Sbjct: 17 EFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPP--INDMFTDLKDGRKLLDLLEGLT 74
Query: 72 GQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIIL 131
G LP E+G R+HA+ N+ L+ L ++LVNI TDI DG + LGL+W+IIL
Sbjct: 75 GTSLPKERGST--RVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIIL 132
Query: 132 YFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYT 191
++Q++++ ++ ++ Q N++K LL WV+ T
Sbjct: 133 HWQVKDVMKDV-----------------------------MSDLQQTNSEKILLSWVRQT 163
Query: 192 AGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELG 251
+ + V +F SW G+AF++V+H +P+L + V S E LE AF+ A+T LG
Sbjct: 164 TRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLG 223
Query: 252 IPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPD-------------------------IH 286
I +LLDPEDV V PD+KSI+ Y+ + P I+
Sbjct: 224 IEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAIN 283
Query: 287 NASTDGQEDDEI-LPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQ 345
ST +E+ E PS V ++ +E+ W+ E + +++
Sbjct: 284 IQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVE 343
Query: 346 ---DKYQSFKHFRVQYEMKRKQIEHLIQ---PLHRDGKLSLD----------------QA 383
D++ + + F ++ + + ++Q L G LS + +A
Sbjct: 344 EVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
Query: 384 LVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQ 443
L +S DR SRL D ++L K L + AWL E +++ T ++ ++Q
Sbjct: 404 LRVESMDR-QSRLHDVLMELQKK---QLQQLSAWLTLTEERIQKMETCPL--DDDVKSLQ 457
Query: 444 RKLEQHKDLLQNTDAHKRAFHE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTS 496
+ LE+HK L + +A + + + + + DQL+ + ER+ V +
Sbjct: 458 KLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWT 517
Query: 497 ELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQY 556
E +++ + + L L+ + LK+W+ + + E++ + ++ S F +Q
Sbjct: 518 EERWNRLQEINI---LWQELLEEQCLLKAWLTE--KEEALNK--------VQTSNFKDQK 564
Query: 557 EVTYQ-----ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEV 611
E++ ILK+ EM + + E + + Q + S + + S EE+
Sbjct: 565 ELSVSVRRLAILKEDMEMKRQTLDQLSE-------IGQDVGQLLDNSKASKKINSDSEEL 617
Query: 612 ISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETC 671
WD + + A L S+ +KD +
Sbjct: 618 TQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLET------------------VRVR 659
Query: 672 DEMVSRDLKQQL-LLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT-LSAFATEAHK 729
++ +++ KQ+L + R++ ++++ + D + E + ++ +A T K
Sbjct: 660 EQAITKKSKQELPPPPPPKKRQIHVDIE---AKKKFDAISAELLNWILKWKTAIQTTEIK 716
Query: 730 KLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
+ + + S M KL + E +R+P D + +T ++ ++ GKE T
Sbjct: 717 EYMKMQDTSEMKKKLKALEKEQ-RERIPRADE----LNQTGQILV----EQMGKEGLPT- 766
Query: 790 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
++K L KV + + + L + +L++ + +++ L ++ ++I E + ++
Sbjct: 767 EEIKNVLEKVSSEWKNVSQHLEDLERKI-QLQEDINAYFKQLDELEKVIKTKEEWVKHTS 825
Query: 850 LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQ 909
+ + Q L + +++C++ LT + +H +
Sbjct: 826 ISESSRQSLPSLKDSCQRELT-----------------------------NLLGLHPKIE 856
Query: 910 SMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQ 969
+ + F+ + V QE +E++ ++H E ++
Sbjct: 857 MARASCSALMSQPSAPDFVQRGFDSFLGRYQAV----QEAVEDR-------QQHLE--NE 903
Query: 970 LDQRVLNAFLKACDELTDILPEQEQ--QGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVE 1027
L + +A+L+ L D+L + E Q + L K K LQ +
Sbjct: 904 LKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTL---------- 953
Query: 1028 KNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD-KGPHH----LCEKRLQLIE 1082
+ L + + +L ETK + + + K ++ F D +G + L K L L+E
Sbjct: 954 -DEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLE 1012
Query: 1083 ELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK--WKDYTSRFSEFSSWI 1140
E+ + L R V K + D ++ D + + S F + I
Sbjct: 1013 EIALTL------RAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEI 1066
Query: 1141 STNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEA 1200
T E+ LK +K I+T +R+G +T W+++RL +
Sbjct: 1067 ETIESSLKNMK--EIET-----------NLRSGPVAGIKT--WVQTRL---------GDY 1102
Query: 1201 QKQGDELAKLSSSFKALVTLLSEVEKMLSNF-GDCVQYKEIVKNSLEELISGSKEVQEQA 1259
Q Q L KLS + LSE ++ +N D + +E + + EE + E +
Sbjct: 1103 QTQ---LEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPE 1159
Query: 1260 EKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLES 1319
E E + A++ +L QK R+ K +++ A+ +P G E +L
Sbjct: 1160 ELESAVEEMKRAKEDVL---QKEVRVKILKDNIKLLAAK-------VPSGGQELTSELNV 1209
Query: 1320 TLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSEL 1379
L+ + R + W + + L H L + L +L +
Sbjct: 1210 VLENYQLLCNRIRGKCHTLEEVWSCW-------IELL------HYLDLETTWLNTLEERM 1256
Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIK 1439
+ T+ ++T+++ E+L + +L+ A + + Q+++L TL +
Sbjct: 1257 KSTEVLPEKTDAVNEALESL-------------ESVLRHPADN-RTQIRELGQTLIDGGI 1302
Query: 1440 TMEMVKTKWDHFGSNFETLSVWITEK----EKELNALETSSSAMDMQISQIKVTIQEIES 1495
+++ K + F S +E LS K EK+L L + D + ++ ++ E++
Sbjct: 1303 LDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRET----DQMLQVLQESLGELDK 1358
Query: 1496 KLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCL-----EGTILGH 1550
+L++ + +A F E+ +I+A+++ EELR + + E
Sbjct: 1359 QLTTYLTDRIDA-----FQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413
Query: 1551 LSQQQKFEENLRKIQ------QSVSEFE----------DKLAVPIKICSSATETYKVLQE 1594
SQ + LR++ Q + FE D + + + V+Q
Sbjct: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQT 1473
Query: 1595 HMDLC----QALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAK 1644
H+D C + L + + + R +V N ++ +L+ Y D+ +
Sbjct: 1474 HLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVT 1533
Query: 1645 ERQTALENLLAHWQRLEKELSSFLTWLERGEA----KASSP----EMDISADRVK-VEGE 1695
E + LE ++++KE +S WL E K++S ++D K V +
Sbjct: 1534 EGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKD 1593
Query: 1696 LQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINK 1755
L+ +A N + ++ L++ E + ++ L L+ W +
Sbjct: 1594 LEKRKADLNTITESSAALQNLIEGSEPI-----------LEERLCVLNAGWSRVRTWTED 1642
Query: 1756 RINFLQSVVAEHQQFDELLLSFSVWI---KLFLSELQ---TTSEISIMDHQVALTRHKDH 1809
N L + + + FD + S W+ + L E++ T+ + I+ V
Sbjct: 1643 WCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLV-------- 1694
Query: 1810 AAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH 1869
+E++ ++++++ L + + L++ K + + FE+ SQ ++ +L ++
Sbjct: 1695 -SELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIA- 1752
Query: 1870 LAEFLQSHASLSGILRQLRQTVEATNSMNKNESDL------IEKDLNDALQNAKALESAA 1923
Q + + +T + + K E+D+ +EK L + ++ K E +A
Sbjct: 1753 -----QEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESA 1807
Query: 1924 VSLDGILSKAQYHL-KIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALA----- 1977
++ +L + + L + ++ R L +I+ + +Q + LA
Sbjct: 1808 -QIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIK-AIPIQQRKMGQLASGIRS 1865
Query: 1978 -VLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC 2036
+L + + ++L ++D+E + L + + ++D+L+ ++
Sbjct: 1866 SLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIA 1925
Query: 2037 WLKDKAKQ-IAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
+ +K I + A ++ + +L WD R+ + +G ++ R++
Sbjct: 1926 VIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDL 1985
Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
+ +++ + A ++V DL+ A + + ++ Q G +
Sbjct: 1986 NDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGI--- 2042
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
++K+ +D S +K + +W + ++++ RL+ DEI W
Sbjct: 2043 VQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLT- 2101
Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQ 2275
+AE +++ + EL + +L++LT+ +E
Sbjct: 2102 ----------------KAEHAMQKRST---------TELGENLQELRDLTQEMEV----- 2131
Query: 2276 FIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL--MNCAQN 2333
HA+++ + + L+ + +S + + K+ ESL +N N
Sbjct: 2132 -----------HAEKLKWLNRTELEMLSDKSLSLPE--------RDKISESLRTVNMTWN 2172
Query: 2334 ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2393
+ C ++V KE + S++S T+ + +K + + S
Sbjct: 2173 KIC---REVPTTLKECIQEPSSVSQTRIAAHPNVQK----------------VVLVSSAS 2213
Query: 2394 QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2453
+ ++ + + S+ +++ E +W + K + GD + + + ++
Sbjct: 2214 DIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITK 2273
Query: 2454 DSVSDGQSKLDAVTQEGQTLYAHL-SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQD 2512
+ +LD V Q L S + ++I E++ + ++ +Q L+D
Sbjct: 2274 ADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLED 2333
Query: 2513 CASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKK---NEVHKVEMFLGELLA 2569
+ ++D + + + E R L ++++ K+ N++ E+ G+ +
Sbjct: 2334 MIIDSLQWDDHREETEELMRKYEARLYI--LQQARRDPLTKQISDNQILLQELGPGDGIV 2391
Query: 2570 ARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLL-TSHQNLLRMTKEKLRSCQVALQEHEA 2628
+ D + Q+ LL E G + + ++ L TS NL + ++ + + + +A
Sbjct: 2392 M--AFDNVLQK--LLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQA 2447
Query: 2629 LEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKG--------EGEVK 2680
L++ W++ AE+T+ R + +QD +L + + E+
Sbjct: 2448 SRRDLENFLKWIQE-------AETTVNVLVDASHRENALQDSILARELKQQMQDIQAEID 2500
Query: 2681 LNMAIGKGEQALRS------SNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQ 2734
+ I K R N E ++Q +L+ + + W D+ + S ++ LE+ +
Sbjct: 2501 AHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEK 2560
Query: 2735 WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
WN + +L +W+ D++++ + + + DH +++ E ++ ++ +
Sbjct: 2561 WNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAV 2620
Query: 2795 AKSRELYEKTEDESFKDTAQE-ELKTQFNDIMTVAK--EKMRKVEEIVKDHLMYLDAVHE 2851
++R E+ ++ + + KT+ K + MRK VK+ L+AV
Sbjct: 2621 DQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAV-- 2678
Query: 2852 FTDWLHSAKEELHRWSDMSG---DSSATQKKLSKIKE--------LIDSREIGASRLSRV 2900
++W + L + D+ G D A K+ ++ LIDS + ++
Sbjct: 2679 TSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAF 2738
Query: 2901 -ESLAP---EVKQ----NTTASGCEL-----MHTEMQALRADWKQWEDSVFQTQSCLENL 2947
E +AP +VK ++ S +L M ++ L WK + SV L+
Sbjct: 2739 REEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEA 2798
Query: 2948 VSQMALSEQEFSGQVAQL 2965
S Q F QL
Sbjct: 2799 HRDFGPSSQHFLSTSVQL 2816
Score = 160 bits (404), Expect = 7e-38
Identities = 497/2812 (17%), Positives = 1064/2812 (37%), Gaps = 360/2812 (12%)
Query: 2754 QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTR--ALHRLIAKSRELYEKTEDESF-- 2809
+K+ P L +K ++ +L S+ A+ + R+ ++ E+E+
Sbjct: 225 EKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI 284
Query: 2810 KDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2869
+ TA EE + + E V E+ D Y A+ E WL SA++ D+
Sbjct: 285 QSTAPEE------EHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDI 338
Query: 2870 SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCE--LMHTEMQALR 2927
S D + + + + + S + V ++ T S E + +M L
Sbjct: 339 SDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLN 398
Query: 2928 ADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE 2987
A W+ QS L +++ ++ ++ L+Q SA L +++ +E
Sbjct: 399 ARWEALRVESMDRQSRLHDVLMELQ-------------KKQLQQLSAWLTLTEERIQKME 445
Query: 2988 GKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
D+++ +LQK + L+S DL KV+ L
Sbjct: 446 TCPLDDDV-----------KSLQKLLEEHKSLQS----------DLEAEQVKVNSLT--- 481
Query: 3048 NCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKI 3107
+ + + ++ IL+ + +K ++W + T + + E++ Q++
Sbjct: 482 HMVVIVDENSGESATAILEDQLQKL---GERWTAVCRWTEERW----NRLQEINILWQEL 534
Query: 3108 QE-------FLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSN 3160
E +L+E E +K+ K + KE + ++ ++ KED +
Sbjct: 535 LEEQCLLKAWLTEKEEALNKVQTSNFKDQ-------KELSVSVR-RLAILKEDMEMKRQT 586
Query: 3161 LHQKE-------SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQ 3213
L Q L+N K K S E Q W S +++ +SSN++ AK
Sbjct: 587 LDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRL-EDSSNQVTQAVAKLGMS 645
Query: 3214 QKLQ-SVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKV 3272
Q Q +LE + E + K+ Q+L K H + ++ A+S +
Sbjct: 646 QIPQKDLLETVRVREQAIT--KKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI 703
Query: 3273 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3332
+ + ++ E++++M D S + KL+AL ++E
Sbjct: 704 LKW--------KTAIQTTEIKEYM------------KMQDTSEMKK---KLKALEKEQRE 740
Query: 3333 KEIQMKMIVTRGESVLQNTSPEGIPT--IQQQLQSVKDMWASL------LSAGIRCKSQL 3384
+ + + G+ +++ EG+PT I+ L+ V W ++ L I+ + +
Sbjct: 741 RIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDI 800
Query: 3385 EGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE------LRDKTTMLGKAKLLNEE 3438
+ + ++ W+ +++ES RQ R+ T +LG +
Sbjct: 801 NAYFKQLDELEKVIKTKEEWV--KHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMA 858
Query: 3439 VLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLH--QE 3496
S S+L+ Q RY+A+QE ++ E ++
Sbjct: 859 RASCSALMSQPSAPD-------FVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHA 911
Query: 3497 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTR 3556
Y LK + L + K + D E L++ + L + L+ +
Sbjct: 912 YLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEET 971
Query: 3557 EDVIPSGIPQAE---DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEW 3613
+ + + P E + + ++ W + +S+ + LR E +++W
Sbjct: 972 KALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKW 1031
Query: 3614 LKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVE-----EVGARAQEILD- 3667
+ ++ + + Q + A + QL Q + E+ ++ E R+ +
Sbjct: 1032 MDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGI 1091
Query: 3668 ESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKN 3727
++ V +R+G TQL + L ++ Q L E + + L+ +W +
Sbjct: 1092 KTWVQTRLGDYQTQL----EKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEE 1147
Query: 3728 FKNVATKI---DKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAE 3784
+ + +++++ + K +VL K++ +K ++ + + G +
Sbjct: 1148 YLERDFEYKSPEELESAVEEMKRAKEDVLQKEVR-----VKILKDNIKLLAAKVPSG-GQ 1201
Query: 3785 RLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
L E++ +E + L + +R + TLE+ E T W+ +E + E
Sbjct: 1202 ELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTE- 1260
Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKS-VREKGEALLE-LVQDVTLKDKIDQLQSD 3902
L EK +++ ++VL H ++ +RE G+ L++ + D + +K++ S
Sbjct: 1261 ---VLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSR 1317
Query: 3903 YQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVA--PDLLET----SSL 3956
Y+DL + + SLE +++ + + LQ +++ L ++ +L D ++
Sbjct: 1318 YEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEA 1377
Query: 3957 ETITQQLAHHKAMMEEI-AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
+ I +++ H+ +EE+ + G D LQ KL++
Sbjct: 1378 QKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLRE----------- 1426
Query: 4016 SYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLE----PSPQPPLSRAE 4071
ST +++ QK + + + C+ L V+ +L P + +
Sbjct: 1427 -----VSTKFQLF-------QKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTH 1474
Query: 4072 AIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQ--NLT 4129
K +K ++ L E L +V T + I Q +QT K + Q +L
Sbjct: 1475 LDKCMKLYKTLSE------------VKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLK 1522
Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL-------ELNIAQNMVSQ-------- 4174
+ ++ +E L+ A Q + MK+ + L E + Q S+
Sbjct: 1523 VLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDT 1582
Query: 4175 ----VKDFVKKLQSKQASVNTIIEKVNKLTKKEESPE---HKEINHLNDQWLDLCRQSNN 4227
K+ +K L+ ++A +NTI E L E E + + LN W + + +
Sbjct: 1583 EISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTED 1642
Query: 4228 LCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE 4287
C + + + + +L + D + + + T+ E +K+L L +
Sbjct: 1643 WCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEI---EKKPTSKQEEIVKRLVSELDD 1699
Query: 4288 RKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK-RKIQVSVTNLEEL 4346
+E+++DQ ++ +ELV+ + + L + + ++ IK K+ ++ L +
Sbjct: 1700 ANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQC 1759
Query: 4347 NVVQSRFQELMEWAE-EQQPNIAEAL-----KQSPPPDMAQNLLMDHLAICSELEAKQML 4400
V F+ + +++ E+ N E + K D + + + I L+ + +
Sbjct: 1760 LVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEM 1819
Query: 4401 LKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEK----- 4455
L ++D N+++ I+ L + N + + Q+RK A +
Sbjct: 1820 LHQPMED----------NKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLP 1869
Query: 4456 TQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWA 4515
T +L+ + + + E + E + +D S Q + K+ + L ++ +
Sbjct: 1870 TDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHE 1929
Query: 4516 QGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKAC 4575
+ +++ E + E ++ L +L + +D + + S R ++ + + F D +
Sbjct: 1930 KQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLT 1989
Query: 4576 HWLKQADIVTF----PEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILP 4631
W+ +A+ + P +L E + +H Q + I P + L RTG I+
Sbjct: 1990 QWITEAEELLVDTCAPGGSLDLEKARIHQQELEV-GISSHQPSF----AALNRTGDGIVQ 2044
Query: 4632 SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELE 4691
L++ D S+L EKL L ++++ IVA KD+ +++ +Y ++ L++ E
Sbjct: 2045 KLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE 2104
Query: 4692 AQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK 4751
+ S T+L L E+ L + ++ +K + T DK
Sbjct: 2105 HAMQKRS--TTELGEN------------LQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150
Query: 4752 MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPA 4811
L L +R + E + K+C+++ LK +E S V++ + A
Sbjct: 2151 SLSL-----------PERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAA 2199
Query: 4812 EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSA 4871
++ L S D + + + P +K ++ W + + +
Sbjct: 2200 HPNVQKV-VLVSSASD-------IPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKS 2251
Query: 4872 IGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP----VYLDLNLQDIQEEIRKI 4927
TV + E E+++++ ++ KA+L Y+ Q+++ +
Sbjct: 2252 NIVTVGDVE-----------EINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSS 2300
Query: 4928 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDG---DIQEALRTR 4984
+ + R+ N + + EL LE + + + D + +E +R
Sbjct: 2301 DMRTAITEKLERVKN-----QWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKY 2355
Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEEN-LKSHMEFFSTED 5043
+A L I Q +R + D Q LLQ G G + A +N L+ +E + ++D
Sbjct: 2356 EARL-YILQQARR-----DPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDD 2409
Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQW 5103
N++E + T +K + + Q E R+ + SR R +
Sbjct: 2410 T--RNVKETTEYLKTSWINLKQSIAD--RQNALEAEWRTVQASR----------RDLENF 2455
Query: 5104 HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALE 5163
+ + E + ++ D + E +L + + E ++++ + +A + N + I
Sbjct: 2456 LKWIQEAETTVNVLVDASHR--ENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNR 2513
Query: 5164 EKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKA 5223
+K ++ GN L + + QRW L+A + LE + ++W +++
Sbjct: 2514 QK--MVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEEL 2571
Query: 5224 TEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGA 5283
+ ++ ++L L ++ EL++++ ++ Q L D
Sbjct: 2572 IKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQP 2631
Query: 5284 APTPGEEPPLMQEITAM--QDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQE 5341
P E +Q T + ++R + + ++ VK++ + V + E
Sbjct: 2632 IEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALE 2691
Query: 5342 TKEYLGNPTIEIDAQLEELQ-----------ILLTEATNHRQNIEKMAEEQKEKYLGLYT 5390
L ++DA ++E + +L+ +H + I EE + T
Sbjct: 2692 KLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKT 2751
Query: 5391 ILPSELSLQLAEVAL--DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKD 5440
+ ++LS QL+ + L LK+ Q+ D + + + + +Q+Q+ +D
Sbjct: 2752 V--NDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRD 2801
Score = 150 bits (378), Expect = 7e-35
Identities = 509/2783 (18%), Positives = 1066/2783 (38%), Gaps = 405/2783 (14%)
Query: 1492 EIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILG-- 1549
++ K S I+ L + Q VT ++ T R+Y +E E A ++ T
Sbjct: 236 QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVE---TLPRKYKKECEEEAINIQSTAPEEE 292
Query: 1550 HLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKV-------LQEHMDLCQAL 1602
H S + + + ++ + ++ L + SA +T++ ++E D
Sbjct: 293 HESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATH 352
Query: 1603 ESLSSAITAFSASARKVVNRDSCV---------------QEAAALQQQYEDILRRAKERQ 1647
E+ +TA +S V+ + + ++ L ++E + + +RQ
Sbjct: 353 EAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQ 412
Query: 1648 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVK-VEGELQLIQALQNEV 1706
+ L ++L Q+ K+L WL E + E D VK ++ L+ ++LQ+++
Sbjct: 413 SRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDL 470
Query: 1707 VSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAE 1766
++ + L + + + + +++ L++L ERW + + +R N LQ +
Sbjct: 471 EAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL 530
Query: 1767 HQQFDELLLSFSVWI--------KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKG 1818
Q+ E W+ K+ S + E+S+ ++A+ + ++E K+
Sbjct: 531 WQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKE-----DMEMKRQ 585
Query: 1819 ELQSLQGHLAKLGSL-GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH-LAEFLQS 1876
L L +G L ++ + +E+ Q ++ Q +E ++ +A+ S
Sbjct: 586 TLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMS 645
Query: 1877 HASLSGILRQLRQTVEATNSMNKNE----SDLIEKDLNDALQNAKALESAAVSLDGILSK 1932
+L +R +A +K E ++ ++ ++ K ++ + L
Sbjct: 646 QIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAEL------ 699
Query: 1933 AQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQ--DQKEEL 1990
+ LK ++ Q T E++ + T + + A+ K+ + + +EL
Sbjct: 700 LNWILKWKTAIQTT-----------EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADEL 748
Query: 1991 LKSIEDIEERTDKERLK-EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKD 2049
++ + + E+ KE L E + L++ + + L E ++ +D Q D
Sbjct: 749 NQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLD 808
Query: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLID-LMREYQNLKSAVSKV-LENAS- 2106
E+++ I E W + ++ L D RE NL K+ + AS
Sbjct: 809 -----ELEKVIKTKE-EWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASC 862
Query: 2107 SVIVTRTTIKD--QEDLKWAFSKHETAKNKMNYKQKDLDNFTS--KGKHLLSELKKIHSS 2162
S ++++ + D Q +++ + + +Q+ L+N G L LK +
Sbjct: 863 SALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKD- 921
Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2222
V D E+ L+V L + L+ T DEI + ++AE
Sbjct: 922 ----VLNDSENKAQVSLNVLNDLAKVEKALQEK--------KTLDEILENQKPALHKLAE 969
Query: 2223 NISNLDN--HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEAD 2280
L+ H E+L K+ +V+ K +L+ L SK DL +E
Sbjct: 970 ETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSK---------------DLHLLE-- 1012
Query: 2281 LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA----QNETC 2336
E+A TL+ F A ST +EK+++ + + K + + + A Q + C
Sbjct: 1013 ------------EIAL-TLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
Query: 2337 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELES-LGRAMTGLIKKHEAVSQL 2395
A V +I+ ++S N+ + NL S +++ LG T L E +S+
Sbjct: 1060 SAF--VNEIET-IESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQL----EKLSKE 1112
Query: 2396 CSKTQASLQESLEK--HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2453
+ ++ L ES EK + + + E QEW A+ E + LE+ + +++
Sbjct: 1113 IATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAK 1172
Query: 2454 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK------ 2507
+ V + ++ + + L A ++ S QE ++ N + + C + +
Sbjct: 1173 EDVLQKEVRVKILKDNIKLLAA----KVPSGGQELTSELNVVLENYQLLCNRIRGKCHTL 1228
Query: 2508 QALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHK-VEMFLGE 2566
+ + C EL + D W++ +EER +S + +PEK + V++ +E
Sbjct: 1229 EEVWSCWIELLHYLDLE---TTWLNTLEERM------KSTEVLPEKTDAVNEALESLESV 1279
Query: 2567 LLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2626
L ++ ++ + GQ L + G + +++L + + K S + LQ
Sbjct: 1280 LRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVL 1339
Query: 2627 EALEEALQSMWFWVKAIQDRLACAESTLGSKDT-LEKRLSQIQDILLMKGEGEVKLNMAI 2685
++ LQ + + +LG D L L+ D + E + K+ I
Sbjct: 1340 RETDQMLQVL--------------QESLGELDKQLTTYLTDRIDAFQVPQEAQ-KIQAEI 1384
Query: 2686 GKGEQALRS--SNKEGQRVIQTQLETLKE-VWADIMSSSVHAQSTLESVISQWNDYVERK 2742
E L N Q + + T + D++ + ST + + ++ +R
Sbjct: 1385 SAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRM 1444
Query: 2743 NQLEQWMESV-------DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
++ ++ V D K P Q L + L L + E E + ++
Sbjct: 1445 LDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQ 1504
Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDI---MTVAKEKMRKVEEIVKDHLMYLDAVHEF 2852
K ++T++ D LK +ND+ +T K+ + + ++ + M +A
Sbjct: 1505 K-----QQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARK--MKKEAA-SL 1556
Query: 2853 TDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTT 2912
++WL + + EL + S G ++S K ++ E + L+ + + + QN
Sbjct: 1557 SEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAAL-QNLI 1615
Query: 2913 ASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQF 2972
++ + L A W + + L N +Q+ + F G VA + L Q
Sbjct: 1616 EGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEI----FDGNVAHISTWLYQA 1671
Query: 2973 SALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQ----LNELCR 3028
ALL ++ T + EEIV+ ++ L A + E+++ Q +N
Sbjct: 1672 EALLDEIEKKPT-----SKQEEIVK------RLVSELDDANLQVENVRDQALILMNARGS 1720
Query: 3029 FSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI--T 3086
SR+L V + E N + S+ ++ + ++ Q Q LV + T
Sbjct: 1721 SSREL------VEPKLAELNRNFEKVSQHIKSAKLLIAQE------PLYQCLVTTETFET 1768
Query: 3087 TAKCFDIPQNISEVSTSLQKIQEFLSESENGQH------KLNMMLSKGE-LLSTLLTKEK 3139
D+ + +++ L+ +++ L S+ + ++ +L +GE +L + K
Sbjct: 1769 GVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNK 1828
Query: 3140 AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHES 3199
+ I+ ++ LH + + ++ + IQ + A I+ L T+ +V +
Sbjct: 1829 KEKIRLQLLL-----------LHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEIN 1877
Query: 3200 SNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAA----------- 3246
L D+ + ++ E+ E L +K++ +L E A
Sbjct: 1878 KILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILE 1937
Query: 3247 -----SKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
+ R ++QL++++ ++ + ++ DR + E QF + +L W+T+A
Sbjct: 1938 ASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEE 1997
Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
+L C P + +R + E + + + + G+ ++Q S +++
Sbjct: 1998 LLVDTCAPGGSLDLEKARIHQQELEVGISSHQP-SFAALNRTGDGIVQKLSQADGSFLKE 2056
Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSME-----ANLNESE 3416
+L + W ++++ + +L+G + Y+ + + W+ E + E
Sbjct: 2057 KLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELG 2116
Query: 3417 RQHAELRDKTTML----GKAKLLNE---EVLSYSSL-----------LETIEVKGAGMTE 3458
ELRD T + K K LN E+LS SL L T+ + +
Sbjct: 2117 ENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICR 2176
Query: 3459 HYVTQLELQDLQERYRAIQER---------------AKEAVTKSEKL--VRLHQEYQRDL 3501
T L+ + +QE Q R A + +S + + + + + +
Sbjct: 2177 EVPTTLK-ECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTI 2235
Query: 3502 KAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVL----HTRE 3557
WL + L V GD T+ ++ + + L+ V + +
Sbjct: 2236 TELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKN 2295
Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTA 3617
S + A LE ++ W QH + + Q +++ + ++ +E ++
Sbjct: 2296 KASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKY 2355
Query: 3618 EEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGC 3677
E ++ + + + TK+I +Q+ +E+ V Q++L+E +
Sbjct: 2356 EARLYILQQARRDPLTKQISDNQILL--QELGPGDGIVMAFDNVLQKLLEEYGSDDTRNV 2413
Query: 3678 QAT--QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWY--GSTHKNFKNVAT 3733
+ T L + + L + ++ LE E ++++ S L ++ W T N A+
Sbjct: 2414 KETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDAS 2473
Query: 3734 KIDKV--DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIH 3791
+ D+++ + + ++ + +++ + + KS ++ VK L E + +
Sbjct: 2474 HRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRL 2533
Query: 3792 DHMEQ----LKELTSTVR-----------KEHMTLE--------KGLHLAKEFS------ 3822
D M Q LK ++++R + M+LE K L K+
Sbjct: 2534 DDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVP 2593
Query: 3823 ------DKCKALTQWIAEYQ----------------EILHVPEEPKMELYEKKAQLSKYK 3860
D CKAL + + E + + + PEEP+ L + K +L+ +
Sbjct: 2594 ALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNL-QSKTELTPEE 2652
Query: 3861 SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAK 3920
Q+ + V+EK E+L + + + ++D+ +DL + + L+A
Sbjct: 2653 RAQKIAKAMRKQSSEVKEKWESLNAVTSN--WQKQVDKALEKLRDL----QGAMDDLDAD 2706
Query: 3921 VKDHEDYNSELQEVEKWLLQ---------MSGR-LVAPDLLETSSLETITQQLA----HH 3966
+K+ E + + V L+ M+ R +AP + ++ ++ QL+ H
Sbjct: 2707 MKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHP 2766
Query: 3967 KAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQR 4026
M +L++L M+ L D +LKQ AH S + ++ Q
Sbjct: 2767 SLKMSR------QLDDLNMRWKLLQVSVDD----RLKQLQEAHRDFGPSSQHFLSTSVQL 2816
Query: 4027 MYQ-SLEHELQKHVSRQDTLQQC 4048
+Q S+ H + T C
Sbjct: 2817 PWQRSISHNKVPYYINHQTQTTC 2839
Score = 145 bits (365), Expect = 2e-33
Identities = 489/2680 (18%), Positives = 1038/2680 (38%), Gaps = 361/2680 (13%)
Query: 5952 SEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMD 6008
+E T+ E YQ +L+ + T + + E E + E Q A H+A M
Sbjct: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMM 357
Query: 6009 EILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLL 6068
E+ Q + + + +L+++ +D E+ +Q +T+L R +R+++ +
Sbjct: 358 ELTAHQSSVGSVLQA-GNQLITQGTLSDE-EEFEIQEQMTLLNARWEALRVESMDR---- 411
Query: 6069 EEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 6128
+ +L+D L E +++Q Q L +WL T+ + + P + D ++
Sbjct: 412 QSRLHDVLMELQKKQLQQ--------LSAWLTLTEERIQKMETCPLDD--------DVKS 455
Query: 6129 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQL 6188
+ +E+ S+L E + + H ++ +G E A+ + QL
Sbjct: 456 LQKLLEEHKSLQSDLEA--EQVKVNSLTHMVVIVDENSG----------ESATAILEDQL 503
Query: 6189 NMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLL 6248
G + W A R WT++R + LQ+ L QEL E++ LL
Sbjct: 504 QKLG--------------------ERWTAVCR--WTEERWNRLQEINILWQELLEEQCLL 541
Query: 6249 RSVASRGEEILIQHSAAETSGDAGEKP--------DVLSQELGMEGEKSSAEDQMRMKWE 6300
++ + EE L + +TS +K +L +++ M+ + ++
Sbjct: 542 KAWLTEKEEAL---NKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVG 598
Query: 6301 SLHQEFSTKQKLLQNVLEQEQE-----QVLYSRPNRLLSGVP-LYKGDVPTQDKSAVTSL 6354
L +K+ + E Q Q L N++ V L +P +D +
Sbjct: 599 QLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRV 658
Query: 6355 LDGLNQAFEEVSSQS----GGAKRQSIHLE---QKLYDGVSATS-TWLDDVEERLFVATA 6406
+ QA + S Q K++ IH++ +K +D +SA W+ ++ + + T
Sbjct: 659 RE---QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI--LKWKTAIQTT 713
Query: 6407 LLPE-----ETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL 6461
+ E +T + L K+ +E D+ N Q E + + + +
Sbjct: 714 EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADE-LNQTGQILVEQMGKEGLPTEEIKNV 772
Query: 6462 LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAE 6521
L ++S V+Q ++ ++Q Q D+ F L + + +I K V ++E
Sbjct: 773 LEKVSSEWKNVSQHLEDLERKIQ----LQEDINAYFKQLDELEKVIKTKEEWVKHTSISE 828
Query: 6522 QI-EAIQQAEDGLKEFDAGI------IELKRRGDKLQVEQPSMQEL-----SKLQDMYDE 6569
+++ +D + + IE+ R + QPS + Y
Sbjct: 829 SSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQA 888
Query: 6570 LMMIIGSRRSGLNQNLTLKSQ----YERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQ 6625
+ + R+ L L K Q Y L+ L D+L + K ++ + ++++
Sbjct: 889 VQEAVEDRQQHLENEL--KGQPGHAYLETLKTLKDVLNDSENKAQVSLNVL-NDLAKVEK 945
Query: 6626 LLDKHKEYFQGLES-----HMILTET-LFRKIISFAVQK-ETQFHTELMAQASAVLKRAH 6678
L + K + LE+ H + ET K + V+K Q ++ + + +
Sbjct: 946 ALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS 1005
Query: 6679 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENE---DRLIDRITLY--- 6732
K LE I T + D + + ++ V+ + + ++ R +D+ + +
Sbjct: 1006 KDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNE 1065
Query: 6733 -QHLKSSLN---EYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELH 6788
+ ++SSL E + L G + + D ++QL +L + + +++S+
Sbjct: 1066 IETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQE 1125
Query: 6789 RLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSK 6847
+ + K + A++ W+ A++ E+ + P+ELE + + +K
Sbjct: 1126 KAANLKK-------DLAEMQEWMTQAEE--EYLERDFEYKSPEELESAVEEMKR----AK 1172
Query: 6848 EVDAQSSLKSSVLSTGNQLLRLKKVDTAT-LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
E Q ++ +L +LL K L SEL+ + + L I L ++
Sbjct: 1173 EDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVW 1232
Query: 6907 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID--INCKQ 6964
+ H + +W++ +E ++ E + + E L+ D ++
Sbjct: 1233 SCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRE 1292
Query: 6965 LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESW 7024
L ++ +L D+ S E+L A N ++ L L K LE L+
Sbjct: 1293 LGQTLIDGGILD----DIIS---------EKLEAFNSRYEDLSHLAESKQISLEKQLQVL 1339
Query: 7025 SEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7084
E + +Q L+ +K+L + D+ ++ Q ++ I A E +E++ +N
Sbjct: 1340 RETDQMLQVLQESLGELDKQLTTY--LTDRIDAFQVPQEAQKIQAEISAHELTLEELRRN 1397
Query: 7085 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7144
+ + ++S T R G +L+ L + S+ F K +
Sbjct: 1398 ------MRSQPLTSPESRTARG------------GSQMDVLQRKLREVSTKFQLFQKPAN 1439
Query: 7145 Y---LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7201
+ +++ + L + L+ V D +Q D K ++L + ++K
Sbjct: 1440 FEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTG 1499
Query: 7202 HPPVTETLTNT-------LKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAST 7254
V + T+ L + + +N+L ++ E Q + QL ++ K K+ AS
Sbjct: 1500 RHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMK---KEAASL 1556
Query: 7255 VQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
+ EL++ +T++ + D + T I ++LK L K L + E L+ +
Sbjct: 1557 SEWLSATETELVQKSTSEGLLGD-LDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615
Query: 7315 DASAASAIQSDQLSLSQHLCALEQALCKQQT-------SLQAGVLDYETFAKSLEALEAW 7367
+ S + L + LC L + +T +L E F ++ + W
Sbjct: 1616 EGS--------EPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTW 1667
Query: 7368 IVEAEEILQGQDPSHSSDLSTIQERM-EELKGQMLKFSSMAPD-LDRLNELGYRLPLNDK 7425
+ +AE +L + +S I +R+ EL L+ ++ L +N G + +
Sbjct: 1668 LYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGS----SSR 1723
Query: 7426 EI--KRMQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE 7482
E+ ++ LNR++ +S + + Q L Q E ET + F +KL +
Sbjct: 1724 ELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPF--SDLEKLEND 1781
Query: 7483 ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE-FNLKLTLLS 7541
I N +E+ +M + ++ G+ +L Q D++ E L+L LL
Sbjct: 1782 IE-NMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLH 1840
Query: 7542 NQWQGV--IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 7599
++ + I Q++ G + S IR + ++ K L+ + + +S + +P +
Sbjct: 1841 TRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELS----LNVP-EL 1895
Query: 7600 ARTLFDEVQFKE------KVFLRQQGSYILTVEAGKQLLLSADSGAEAA-LQAELAEIQE 7652
++++ F+E K L + G I + + ++ SG EA ++ L ++
Sbjct: 1896 NTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNA 1955
Query: 7653 KWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSL-PDHHEELHAEQ 7711
KW + ++K +++W + + D + + ++ L + P +L +
Sbjct: 1956 KWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKAR 2015
Query: 7712 MRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLR 7771
+ +ELE + S L+ D + +S D S L E++ L ++W+ + ++ R
Sbjct: 2016 IHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDR 2075
Query: 7772 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQE 7831
+ ++ + + + E+ WLT+ E + + + E +++L +D +E+ + E
Sbjct: 2076 QPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQEL-RDLTQEMEVHAE 2134
Query: 7832 -----NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK------- 7879
N+ +L+ + ++ K SE L VN W + + +K+
Sbjct: 2135 KLKWLNRTELEMLSDKSLSLPERDKISE---SLRTVNMTWNKICREVPTTLKECIQEPSS 2191
Query: 7880 LKETLVAVQ-----------------------------QLDKNMSSLRTWLAHIESELAK 7910
+ +T +A LDK ++ L WL I+ L
Sbjct: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKS 2251
Query: 7911 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7970
IV + EEI + ++ + + D+E+ + V L + L + A ++D +I
Sbjct: 2252 NIVTVG-DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKN--KASSSDMR-TAIT 2307
Query: 7971 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER-TAAFPSSSG 8029
+ + +W R+ ++E+ + D +++D + +E + +
Sbjct: 2308 EKLERVKNQWDGTQHGVELRQQQLED-------MIIDSLQWDDHREETEELMRKYEARLY 2360
Query: 8030 VIYTVAKEELKKFEAFQRQVHECLTQ--------LELINKQYRRLARENRTDSACSLKQM 8081
++ ++ L K Q ++ L Q + + ++L E +D ++K+
Sbjct: 2361 ILQQARRDPLTK----QISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKET 2416
Query: 8082 VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--E 8139
W NL++ + L+ + ++ L W+ E + + + S E
Sbjct: 2417 TEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRE 2476
Query: 8140 CDVQAKI--KQLKAFQQEISLN---HNKIEQIIAQGEQLIEKS--EPLDAAIIEEELDEL 8192
+Q I ++LK Q+I HN I + I Q + K+ +A +++ LD++
Sbjct: 2477 NALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM 2536
Query: 8193 RRYCQEVFGR-----------VERYHKKLIRLPLPDDEHDLSDRELELE-----DSAALS 8236
+ ++ + E++++ L+ L ++ D EL+ + D AL
Sbjct: 2537 NQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQ 2596
Query: 8237 DLHWHDRSADSLLSPQPSSNLS------LSLA-QPLRS-ERSGRDTPASVDSIPLEWDHD 8288
+ H ++ L + S L+ + LA QP+ + E R+ + + P
Sbjct: 2597 LQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTP------ 2650
Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQ 8348
+ +++A+ + E ++ + ++R L A+DD
Sbjct: 2651 ----EERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDAD 2706
Query: 8349 IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLH 8408
+++ E++ P G L S + +++ + I + + K + S ++LH
Sbjct: 2707 MKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPI-NFKVKTVNDLSSQLSPLDLH 2765
Query: 8409 STETQTAGVID---RWELLQAQALSKELRMKQNLQKWQQF 8445
+ + + D RW+LLQ +S + R+KQ + + F
Sbjct: 2766 PSLKMSRQLDDLNMRWKLLQ---VSVDDRLKQLQEAHRDF 2802
Score = 142 bits (359), Expect = 1e-32
Identities = 486/2653 (18%), Positives = 1001/2653 (37%), Gaps = 373/2653 (14%)
Query: 5376 KMAEEQKEKYLGLYTILP--------SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATS 5427
K +E +E+ + + + P +E + EV +DL D Q ++EV ++
Sbjct: 272 KYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDL---DSYQIALEEVLTWLLSA 328
Query: 5428 QELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFL 5487
++ ++ ++ D+ + + +++ Q +G L N + + + ++
Sbjct: 329 EDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEF 388
Query: 5488 EQNGQLGKPLAKKIGKLTELHQQTIR-QAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5546
E Q+ L + +R ++ +R S+L+ L++ + L+ + W+
Sbjct: 389 EIQEQM---------TLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQQLSAWL--- 434
Query: 5547 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY--------- 5597
L I L + Q LLEE K + S+LEA K+ LT +
Sbjct: 435 -TLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGE 493
Query: 5598 -CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
T + Q+ +LG + + + R LQ+ ++ E L+A L + + L
Sbjct: 494 SATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALN 553
Query: 5657 SPEVGRLSLKEQLS---HRQHLLSEMESLKPKV--QAVQLCQSALRIPEDVVASLPLCHA 5711
+ +++LS R +L E +K + Q ++ Q ++ ++ AS +
Sbjct: 554 KVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSD 613
Query: 5712 ALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI 5771
+ L + L N + AV + + K L + + + ++ + +
Sbjct: 614 SEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVR-----VREQAITKKSK 668
Query: 5772 QEL-------QAQISRHEELAQKIKGYQEQIAS--LNSKCKMLTMKAKHATMLLTVTEVE 5822
QEL + QI E +K ++ + L K + T + K + +E++
Sbjct: 669 QELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMK 728
Query: 5823 GLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSP 5882
+ E E +P A + + E+ G+EG +E +
Sbjct: 729 KKLKALEKEQRERIPR-----------ADELNQTGQILVEQMGKEGLPTEEIKNVLEKVS 777
Query: 5883 SPVANTDA---------SVNQDI-AYYQALSA--ERLQTDAAKI-HPSTSASQEFYEPGL 5929
S N + +DI AY++ L + ++T + H S S S P L
Sbjct: 778 SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837
Query: 5930 EPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ----SISTKMEAIELK 5985
+ S +L +L + E R AL Q D +Q S + +A++
Sbjct: 838 KDSCQRELTNLLGLHPKI-----EMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEA 892
Query: 5986 LSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQS 6045
+ + + + H A ++ + L+D +N+ ++ L + A + L +
Sbjct: 893 VEDRQQHLENELKGQPGH-AYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKK 951
Query: 6046 TLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ---------------------- 6083
TL + E K + + + LE+ ++ +E+ +++
Sbjct: 952 TLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLL 1011
Query: 6084 -----ALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6138
L+ + ++ ++ W+ K L + + ++ QL C + EIE
Sbjct: 1012 EEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIES 1071
Query: 6139 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE 6198
+L + NL A K + G + L +L + + ++ + + ++
Sbjct: 1072 SLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQT---QLEKLSKEIATQKSRLSESQEKAA 1128
Query: 6199 ESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEI 6258
DL +QEW+ QA + + R + +ELE + E K V + +
Sbjct: 1129 NLKKDLAE-----MQEWMTQAEEEYLE-RDFEYKSPEELESAVEEMKRAKEDVLQKEVRV 1182
Query: 6259 -LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQMRMKWESLHQEFSTKQKLLQ-- 6314
+++ + + L+ EL + E +++R K +L + +S +LL
Sbjct: 1183 KILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYL 1242
Query: 6315 -------NVLEQEQE--QVLYSRPNRL------LSGVPLYKGDVPTQDKSAVTSLLDG-- 6357
N LE+ + +VL + + + L V + D TQ + +L+DG
Sbjct: 1243 DLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGI 1302
Query: 6358 -----------LNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVA-- 6404
N +E++S A+ + I LE++L + T L ++E L
Sbjct: 1303 LDDIISEKLEAFNSRYEDLSHL---AESKQISLEKQL-QVLRETDQMLQVLQESLGELDK 1358
Query: 6405 --TALLPEETETCLFNQEILAKDIKEMSEEM---DKNKNLFSQAF--PEN-----GDNRD 6452
T L + + QE + + E+ + +N+ SQ PE+ G D
Sbjct: 1359 QLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMD 1418
Query: 6453 VIEDTLGCLLGRLSLLDSVVN--QRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
V++ L + + L N QR K L + + +L VL D
Sbjct: 1419 VLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGV---KAELHVLDVKDVD-------- 1467
Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSM--QELSKLQDMYD 6568
+V + + + ++ + + E + I + K Q + P ++L+ L+ +Y+
Sbjct: 1468 -PDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYN 1526
Query: 6569 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQ---------EKMAGDQKIIVSS 6619
+L + + L + L + ++ L++ L + E + GD +S
Sbjct: 1527 DLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISW 1586
Query: 6620 KEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 6679
+ + + L+K K +TE+ S A+Q + ++ + VL
Sbjct: 1587 AKNVLKDLEKRKADLN------TITES------SAALQNLIEGSEPILEERLCVLNAGWS 1634
Query: 6680 RGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT--------- 6730
R + E W + + Q QLE+ + ++ + + L+D I
Sbjct: 1635 R---VRTWTEDWCNTLMNHQN---QLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEE 1688
Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRL 6790
+ + L S L++ ++ V D L+ + S E +L E N K+S+ +
Sbjct: 1689 IVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAEL-NRNFEKVSQHIKSA 1747
Query: 6791 ETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVT--VPQELEMVRDHLNAFLEFSKE 6848
+ ++ YQ + ++ + + F + + + L+ V HL + E K
Sbjct: 1748 KLLIAQEPLYQC-----LVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEK- 1801
Query: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
+D +S+ VL G ++L D +R +L + +++ + IP Q K+ QL
Sbjct: 1802 MDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKA-IPIQQRKMGQL- 1859
Query: 6907 MDKLPSRHAISEVMSWISLME-NVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI--NCK 6963
+ S ++ L+E N I D+++ S+ ++ + + F+ D N K
Sbjct: 1860 -----ASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIK 1914
Query: 6964 QLTVDFVNQSVLQISSQD----VESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEG 7019
+D + + + I + +E+ + + L +N W + + +++ +
Sbjct: 1915 D-QLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDR 1973
Query: 7020 LLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
+E W ++ ++ L W E+ L G ++ A Q+LE I + +
Sbjct: 1974 AMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFA 2033
Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
+ + G ++Q + S + L L Q W + V + LK Q ++
Sbjct: 2034 ALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQL 2093
Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL- 7198
D+I +L +A +++ + + +NLQ L+D ++ E +K + L
Sbjct: 2094 DEIICWLTKAEHAMQK--------RSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELE 2145
Query: 7199 ----KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ---------SSKALLQLWQRYK 7245
K P + ++ +L+ VNM WN + E+ L+ S + K
Sbjct: 2146 MLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQK 2205
Query: 7246 DYSKQCASTVQQQEDRTNEL-LKAATNKDIADDEVATWIQDCNDLLKG----LGTVKD-- 7298
AS + Q RT+E+ + A +K I E+A W+ + +LK +G V++
Sbjct: 2206 VVLVSSASDIPVQSHRTSEISIPADLDKTIT--ELADWLVLIDQMLKSNIVTVGDVEEIN 2263
Query: 7299 ------------------SLFFLHELGEQLKQQVDASAASAIQSDQLS-LSQHLCALEQA 7339
L ++ L + LK + +S +++L + +
Sbjct: 2264 KTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHG 2323
Query: 7340 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL----QGQDPSHSSDLSTIQERMEE 7395
+ +Q L+ ++D + E E + + E L Q + + +S Q ++E
Sbjct: 2324 VELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQE 2383
Query: 7396 L---KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 7452
L G ++ F ++ L L E G N KE + L W + +R + L+
Sbjct: 2384 LGPGDGIVMAFDNVLQKL--LEEYGSDDTRNVKE--TTEYLKTSWINLKQSIADRQNALE 2439
Query: 7453 SFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQH--LLEQQRAHEL------FQAEM 7504
+ Q E +++++ + E + V + +++ L + A EL QAE+
Sbjct: 2440 AEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEI 2499
Query: 7505 FSRQQILHSIIIDGQRLLEQ-GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR 7563
+ I SI + Q++++ G ++ +L ++ +W + ++ R +++
Sbjct: 2500 DAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAE 2559
Query: 7564 QWQRYREMAEKLRKWL-----VEVSYLPMSG-LGSVPIPLQQARTLFDEVQFKE------ 7611
+W R E+L KWL +P+ G + ++ + + L E++ KE
Sbjct: 2560 KWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNA 2619
Query: 7612 ----KVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKK 7667
+VFL Q +EA ++ + S E + +I + + S ++E+ +
Sbjct: 2620 VDQARVFLADQ-----PIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWES 2674
Query: 7668 LAFLLKDWEKCEKGIADSLEKLRTFK------------------------KKLSQSLPDH 7703
L + +W +K + +LEKLR + L SL DH
Sbjct: 2675 LNAVTSNW---QKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDH 2731
Query: 7704 HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEE 7763
E++ A + + V + D +QLS L D + + + LN R +LLQ ++
Sbjct: 2732 IEKIMAFREEIAPINFKVKTVNDLSSQLSPL-DLHPSLKMSRQLDDLNMRWKLLQVSVDD 2790
Query: 7764 LCHQLSLRRQQIG 7776
QL + G
Sbjct: 2791 RLKQLQEAHRDFG 2803
Score = 130 bits (326), Expect = 8e-29
Identities = 481/2684 (17%), Positives = 1061/2684 (39%), Gaps = 376/2684 (14%)
Query: 3587 SETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHE 3646
+ET + V L + ++V WL +AE+ + + + Q + +
Sbjct: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMM 357
Query: 3647 EVTAYRDEVEEVGARAQEILDESHVNSR----MGCQATQLTSRYQALLLQVLEQIKFLEE 3702
E+TA++ V V +++ + ++ + Q T L +R++AL ++ +++ L +
Sbjct: 358 ELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHD 417
Query: 3703 EIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
+ L++ + L S W T + +I K++T + +K+L+ LL++ + S
Sbjct: 418 VLMELQKKQ--LQQLSAWLTLTEE-------RIQKMETCPLDDDVKSLQKLLEEHKSLQS 468
Query: 3763 LLKSAREKGE---RAVKYLEEGEAERLRKEIHDHMEQLKELTSTV----RKEHMTLEKGL 3815
L++ + K V ++E E + D +++L E + V + L++
Sbjct: 469 DLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEIN 528
Query: 3816 HLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKS 3875
L +E ++ L W+ E +E L+ K Q S +K ++ +S
Sbjct: 529 ILWQELLEEQCLLKAWLTEKEEALN------------KVQTSNFKDQKELSVS------- 569
Query: 3876 VREKGEALLELVQDVTLKDK-IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEV 3934
VR L L +D+ +K + +DQL QD V L K + NS+ +E+
Sbjct: 570 VRR----LAILKEDMEMKRQTLDQLSEIGQD--------VGQLLDNSKASKKINSDSEEL 617
Query: 3935 -EKW--LLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI 3991
++W L+Q LE SS + +TQ +A K M +I +D L ++++ +
Sbjct: 618 TQRWDSLVQR---------LEDSSNQ-VTQAVA--KLGMSQIPQ-KDLLETVRVREQAIT 664
Query: 3992 GQCADHLQAK---LKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 4048
+ L K+ +H ++ A++ + ++ EL + +
Sbjct: 665 KKSKQELPPPPPPKKRQIHVDIE------------AKKKFDAISAELLNWILK------- 705
Query: 4049 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4108
W +A+Q + + + + K +AL+++ R + + V+
Sbjct: 706 --WKTAIQTT---EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMG 760
Query: 4109 KDIQQTEQ---TIEQKLVQAQNLTQGWEEIKH---LKSELWIYLQDADQQLQNMKRR--- 4159
K+ TE+ +E+ + +N++Q E+++ L+ ++ Y + D+ + +K +
Sbjct: 761 KEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEW 820
Query: 4160 --HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKV----NKLTKKEESPEHKEINH 4213
H+ + + Q++ S +KD ++ + ++ IE + L + +P+ +
Sbjct: 821 VKHTSISESSRQSLPS-LKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGF 879
Query: 4214 LNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSD--AEST 4271
D +L + R++ L+ +LE T D L S+ A+ +
Sbjct: 880 --DSFLGRYQAVQEAVEDRQQHLENELKGQPG----HAYLETLKTLKDVLNDSENKAQVS 933
Query: 4272 AVHLEALKKLALALQERKYAIEDLKDQK----------QKMIEHLNLDDKELVKEQTSHL 4321
L L K+ ALQE+K E L++QK + + ++++ D ++L K++ +
Sbjct: 934 LNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDV 993
Query: 4322 EQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL--KQSPPPDM 4379
+ +W +L+ L+ + + + LEE+ + F+ E+ + + L +Q+ D
Sbjct: 994 QGKWNKLKVLVSKDLHL----LEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDD 1049
Query: 4380 A--QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCL 4437
A Q L A +E+E + LK++ + + + + +Q L D Q+ + L
Sbjct: 1050 AGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKL 1109
Query: 4438 SDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCK 4497
S + ++ L+++ + + + + Q E + + R+ P+++ V+ K
Sbjct: 1110 SKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMK 1169
Query: 4498 SAQASLKTYQNEVTGLWAQGRELMKEVT---EQEKSEVLGKLQELQSVYDSVLQKCSHRL 4554
A+ + + V L + L +V ++ SE+ L+ Q + + + KC H L
Sbjct: 1170 RAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKC-HTL 1228
Query: 4555 QELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPE 4614
+E+ + H+ D WL + L ++ ++ L +++L +
Sbjct: 1229 EEVWSCWIELLHY---LDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPAD 1285
Query: 4615 YENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARK 4674
++ GQT++ + +SEKL A ++ + LA+ K +++ + +
Sbjct: 1286 NRT---QIRELGQTLID--GGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLR 1340
Query: 4675 EYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
E ++++ +SL EL+ Q ++ TD +A + + I E++ ++EL
Sbjct: 1341 ETDQMLQVLQESLGELDKQ---LTTYLTDRI--DAFQVPQEAQKIQAEISAHELTLEELR 1395
Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL---- 4790
+ T + + + + R R+ + L + + +++ C+++
Sbjct: 1396 RNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPAN-FEQRMLDCKRVLDGV 1454
Query: 4791 --ERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDP 4848
E + VK+ V + L ++ +K+Y +L+ + V+K H+ +P
Sbjct: 1455 KAELHVLDVKDVDPDVIQTHL--DKCMKLYKTLSEVKLEVETVIK-TGRHIVQKQQTDNP 1511
Query: 4849 LAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSL----DWLRRVK 4904
++ Q+ S LK+L + +G VTE + + ++ +M + +WL +
Sbjct: 1512 KGMDE---QLTS----LKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATE 1564
Query: 4905 AELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-- 4962
EL + L D+ EI + ++++ +N ++ E + LI
Sbjct: 1565 TELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTIT----ESSAALQNLIEGSEP 1620
Query: 4963 -LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN 5021
LE L L+ ++ TL +Q + + + WL A+ LL +
Sbjct: 1621 ILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALL----D 1676
Query: 5022 GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELR 5081
++ + + + S D + +E + L + +E +E K+A L
Sbjct: 1677 EIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRN 1736
Query: 5082 SQRMSRDSG------AQVDLLQ-RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSS 5134
+++S+ AQ L Q T + + ++ +L ND E L + K
Sbjct: 1737 FEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLK--FVEKHLE 1794
Query: 5135 SHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTR 5194
S + +EK+ E A + V L+ L + D K + + + R+ +
Sbjct: 1795 SSDEDEKMDEESAQIEEV---------LQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNK 1845
Query: 5195 LRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYH 5254
++A+ Q K+ + A +G + + +++ + L E + L Y
Sbjct: 1846 IKAIPIQQRKMGQLA----SGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYE 1901
Query: 5255 DTFVLE---------LEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCL 5305
D E L++ + ++ ++ ++ + + P + + ++ A DR
Sbjct: 1902 DFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRIN 1961
Query: 5306 NMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP-----TIEIDAQLEEL 5360
M K + +++ +N + W+ E +E L + +++++
Sbjct: 1962 RMYSDRK---GCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQ 2018
Query: 5361 QILLTEATNHRQN-----------IEKMAEEQ----KEKYLGL---YTILPSELSLQ--- 5399
Q L ++H+ + ++K+++ KEK GL + + +E+ +
Sbjct: 2019 QELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPR 2078
Query: 5400 -LAEVALDLKIRDQIQDKI-----KEVEQSKATSQELSRQIQKLAKDLTTIL----TKLK 5449
E +K R Q+ + I E K ++ EL +Q+L +DLT + KLK
Sbjct: 2079 LKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQEL-RDLTQEMEVHAEKLK 2137
Query: 5450 AKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF-----------------LEQNGQ 5492
++ +D+ + E D + L ++ K + Q
Sbjct: 2138 WLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRI 2197
Query: 5493 LGKPLAKK---IGKLTELHQQTIRQAENRL-SKLNQAASHLEEYNEMLELILK------- 5541
P +K + +++ Q+ R +E + + L++ + L ++ +++ +LK
Sbjct: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVG 2257
Query: 5542 -WIEKAKVLAHGTIAWNSASQLREQ----YILHQTLLEESKEIDSELEAMTEKLQYLTSV 5596
E K ++ I Q Q + L Q L ++ D A+TEKL+ + +
Sbjct: 2258 DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMR-TAITEKLERVKNQ 2316
Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQ---NLQDAAKDMKKFEAELKKLQAALEQAQA 5653
+ +Q EL ++L MI LQ + ++ + M+K+EA L LQ A +
Sbjct: 2317 W---DGTQHGVEL--RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQA---RRD 2368
Query: 5654 TLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAAL 5713
LT L ++L ++ +++ K+ + E + L + +
Sbjct: 2369 PLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKE---TTEYLKTSWI 2425
Query: 5714 RLQEEASRLQHTAIQQCNIMQAAVVQYEQY----EQEMKHLQQLIEGAHRE--IEDKPVA 5767
L++ + Q+ + +QA+ E + ++ + L++ +HRE ++D +A
Sbjct: 2426 NLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILA 2485
Query: 5768 ---TSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTM---------------KA 5809
+Q++QA+I H ++ + I G ++++ + TM KA
Sbjct: 2486 RELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKA 2545
Query: 5810 KHAT--------------MLLTVTE-VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 5854
K A+ +L+++ E ++ L E+L + +P P+ + + C
Sbjct: 2546 KSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQ-MPIGGDVPA-LQLQYDHCK 2603
Query: 5855 TLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 5914
L + E+ V N +V+Q + E + +
Sbjct: 2604 ALRRELKEKE------------------YSVLN---AVDQARVFLADQPIEAPEEPRRNL 2642
Query: 5915 HPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS 5974
T + E + + + +++ WE+L V S Q+ + +ALE+ + Q ++
Sbjct: 2643 QSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDD 2702
Query: 5975 ISTKMEAIELKLSESPEPGRSPESQMA--EHQALMDEILMLQDEINELQSSL--AEELVS 6030
+ ++K +ES G P + Q +++I+ ++EI + + +L S
Sbjct: 2703 LDA-----DMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSS 2757
Query: 6031 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6074
+ D L + L L R +++ + + L+E D
Sbjct: 2758 QLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRD 2801
Score = 121 bits (303), Expect = 3e-26
Identities = 499/2775 (17%), Positives = 1038/2775 (37%), Gaps = 365/2775 (13%)
Query: 1233 DCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDV 1292
D Y+ ++ L L+S QEQ + D E E + H+ ++A + V
Sbjct: 310 DLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVE---EVKDQFATHEAFMMELTAHQSSV 366
Query: 1293 QQQIAQAQQ--GEGGLPDRGHEELRKLESTLDGL-----ERSRERQERRIQVTLRKWERF 1345
+ Q +G L D E+++ + L+ S +RQ R V +
Sbjct: 367 GSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLM------ 420
Query: 1346 ETNKETVVRYLFQTGSSHERFLSFSS------LESLSSELEQTKEFSKRTESIAVQAENL 1399
E K+ + + + ER + ++SL LE+ K E+ V+ +L
Sbjct: 421 ELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSL 480
Query: 1400 VKEASEIP--LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFET 1457
+ G +L+ Q + + E+ + EE ++ + W
Sbjct: 481 THMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL 540
Query: 1458 LSVWITEKEKELNALETSS----SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQF 1513
L W+TEKE+ LN ++TS+ + + + ++ + +++E K ++ L E Q Q
Sbjct: 541 LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQL 600
Query: 1514 VTTGESARI----KAKLTQ-----IRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKI 1564
+ ++++ +LTQ ++R + + Q + + + Q+ E +
Sbjct: 601 LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVRE 660
Query: 1565 QQSVSEFEDKLAVP----------------------------IKICSSATETYKVLQEHM 1596
Q + + +L P I +A +T ++ +E+M
Sbjct: 661 QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEI-KEYM 719
Query: 1597 DLCQALESLSSAITAFSASARKVVNR-DSCVQEAAALQQQYEDILRRAKERQTALENLLA 1655
+ Q + + A R+ + R D Q L +Q +E + LE + +
Sbjct: 720 KM-QDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSS 778
Query: 1656 HWQ-------------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQAL 1702
W+ +L+++++++ L+ E + E + + E Q + +L
Sbjct: 779 EWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSIS-ESSRQSLPSL 837
Query: 1703 ----QNEVVSQASFYSKLLQLKESLFSVASKDDVK-MMKLHLEQLDERWRDLPQIINKRI 1757
Q E+ + + K+ + S ++ S+ ++ + R++ + + + R
Sbjct: 838 KDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQ 897
Query: 1758 NFLQSVVAE---HQQFDEL-------------------LLSFSVWIKLFLSELQTTSEIS 1795
L++ + H + L +L+ ++ L E +T EI
Sbjct: 898 QHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEI- 956
Query: 1796 IMDHQVALTRHKDHAAEVESK---------KGELQSLQGHLAKLGSLGRAEDLHLLQGKA 1846
+ + + AL + + +E K E +QG KL L ++DLHLL+ A
Sbjct: 957 LENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLV-SKDLHLLEEIA 1015
Query: 1847 EDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIE 1906
+ FE S V+E+ + + +FL + G L++ ++ ++ NE + IE
Sbjct: 1016 LT-LRAFEADSTVIEKW---MDGVKDFLMKQQAAQGDDAGLQRQLDQCSAF-VNEIETIE 1070
Query: 1907 KDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL 1966
L + + L S V+ GI K ++G + + ++L E+ ++ L
Sbjct: 1071 SSLKNMKEIETNLRSGPVA--GI--KTWVQTRLGDYQTQL------EKLSKEIATQKSRL 1120
Query: 1967 GTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLED 2026
Q +A A LKK + +E + ++ E+ ER + + E A+++ R ++
Sbjct: 1121 SESQEKA---ANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA----KE 1173
Query: 2027 ELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLID 2086
++ E + LKD K +A K + E+ E+N V ++ + L + +G+C L +
Sbjct: 1174 DVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELN---VVLENYQLLCNRIRGKCHTLEE 1230
Query: 2087 L------MREYQNLKSAVSKVLENA--SSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYK 2138
+ + Y +L++ LE S+ ++ T E L E+ ++ + +
Sbjct: 1231 VWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEAL-------ESLESVLRHP 1283
Query: 2139 QKDLDNFTSKGKHLLS----------ELKKIHS--SDFSLVKTDMESTVDKWLDVSEKLE 2186
+ G+ L+ +L+ +S D S + + +++K L V + +
Sbjct: 1284 ADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETD 1343
Query: 2187 ENMDRLRVSLSIWDDVLST--RDEIEGWSNNCVPQMAENI-SNLDNH-LRAEELLKEFES 2242
+ + L+ SL D L+T D I+ + VPQ A+ I + + H L EEL + S
Sbjct: 1344 QMLQVLQESLGELDKQLTTYLTDRIDAFQ---VPQEAQKIQAEISAHELTLEELRRNMRS 1400
Query: 2243 E-VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKD 2301
+ + + R S+++ L+ + + T L A+ Q++ K + + K L
Sbjct: 1401 QPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHV 1460
Query: 2302 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQS-NISSTQ 2360
+ + I T K + L E +K + +Q QQ+ N
Sbjct: 1461 LDVKDVDPDV----IQTHLDKCMK-LYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMD 1515
Query: 2361 ENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQE 2420
E L SL Y+ LG +T + E SQL K + + E
Sbjct: 1516 EQLTSLKVLYND-----LGAQVTEGKQDLERASQLARKMK------------KEAASLSE 1558
Query: 2421 WFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQ 2480
W + + S G L+ ++ +N+L + ++ L+ +T+ L +L +
Sbjct: 1559 WLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQ-NLIEG 1617
Query: 2481 IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT 2540
++E++ N + L + ++L F+ ++ W+++ E
Sbjct: 1618 SEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEAL--- 1674
Query: 2541 ENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQ 2600
L E ++ K+ E+ V+ + EL A ++ + + +L G+ + +
Sbjct: 1675 --LDEIEKKPTSKQEEI--VKRLVSELDDANLQVENVRDQALILMN-ARGSSSRELVEPK 1729
Query: 2601 LLTSHQNL-----------LRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLAC 2649
L ++N L + +E L C V + E + I++ L
Sbjct: 1730 LAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFET-GVPFSDLEKLENDIENMLKF 1788
Query: 2650 AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRV----IQT 2705
E L S D EK + I + GE L+ Q + + KE R+ + T
Sbjct: 1789 VEKHLESSDEDEKMDEESAQIEEVLQRGEEMLH-------QPMEDNKKEKIRLQLLLLHT 1841
Query: 2706 QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPG 2765
+ +K + A S++ DY+ N++ M+ V+ + P +
Sbjct: 1842 RYNKIKAIPIQQRKMGQLASGIRSSLLP--TDYLVEINKILLCMDDVELSLNVP-ELNTA 1898
Query: 2766 LKEKFVLL-DHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDI 2824
+ E F D L++I + L +L + ++EK D + + E + Q D
Sbjct: 1899 IYEDFSFQEDSLKNIKDQ-------LDKLGEQIAVIHEKQPDVILEASGPEAI--QIRDT 1949
Query: 2825 MTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRW----SDMSGDSSATQKKL 2880
+T K ++ + D D E H +L +W ++ D+ A L
Sbjct: 1950 LTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSL 2009
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
K I +E+ S S A N T G + +AD ++ +
Sbjct: 2010 DLEKARIHQQELEVGISSHQPSFAA---LNRTGDGIV-----QKLSQADGSFLKEKLAGL 2061
Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWH 3000
+ +V+++ + G+ Q+ + Q ++ W LT E E
Sbjct: 2062 NQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEII-CW---LTKAEHAMQKRSTTELGE 2117
Query: 3001 KGQEILDALQKAEPRTEDLK----SQLNELCRFSRDLSTYSGKVSGLIKE----YNCLCL 3052
QE+ D Q+ E E LK ++L L S L K+S ++ +N +C
Sbjct: 2118 NLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERD-KISESLRTVNMTWNKICR 2176
Query: 3053 QAS---KGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKC-----------FDIPQNIS 3098
+ K C + + Q A + Q+ ++ + + D+ + I+
Sbjct: 2177 EVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTIT 2236
Query: 3099 EVSTSLQKIQEFLSES--------ENGQHKLNMMLSKGEL---------LSTLLTKEKAK 3141
E++ L I + L + E + M ++K +L + TL K K
Sbjct: 2237 ELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNK 2296
Query: 3142 GIQAKV-TAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESS 3200
+ + TA E + + + +E + Q++D + + D +TE+++ +
Sbjct: 2297 ASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYE 2356
Query: 3201 NRLYDLPAKRREQ-----QKLQSVLEEIHCYEPQLNRLKEKAQQLWE--GQAASKSFRHR 3253
RLY L RR+ Q +L+E+ + + Q+L E G +++ +
Sbjct: 2357 ARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKET 2416
Query: 3254 VSQLSSQYLALSNLTKEKVSRLDR----IVAEHNQFSLGIKELQDWMTDAIHMLDSYCHP 3309
L + ++ L ++ + L+ + A +K +Q+ T ++D+
Sbjct: 2417 TEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRE 2476
Query: 3310 TSDKSVLDSRTLKLEAL---LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSV 3366
+ + + +R LK + + +I + R + V + E +Q +L +
Sbjct: 2477 NALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM 2536
Query: 3367 KDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKT 3426
W L + ++ LE + KW + + W++ + L + ++
Sbjct: 2537 NQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQ 2596
Query: 3427 TMLGKAKLLNEEVLSYS-SLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEA 3483
K L E+ S+L ++ + + + E ++LQ + E +
Sbjct: 2597 LQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQK 2656
Query: 3484 VTKS--EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVH 3541
+ K+ ++ + ++++ W Q + L++ L+G + +++ + ++
Sbjct: 2657 IAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNG 2716
Query: 3542 CAE-GQALLNS-------VLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3593
G L++S ++ RE++ P L S H + Q
Sbjct: 2717 WKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDL--HPSLKMSRQL 2774
Query: 3594 NNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQL-HQMKKWHEEVTAYR 3652
+++ + +L++ VD+ LK +E + + +QL Q H +V Y
Sbjct: 2775 DDLNMRWKLLQ---VSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKVPYYI 2831
Query: 3653 D--------EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLE--- 3701
+ + ++ Q + D ++V A ++ +AL L +LE E
Sbjct: 2832 NHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFK 2891
Query: 3702 -------EEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK--------VDTVMMGK- 3745
+++ S+ + + L++ D HK+ NV +D DT GK
Sbjct: 2892 QHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKI 2951
Query: 3746 KLKTLEVLLKDMEKG 3760
++++L++ L + KG
Sbjct: 2952 RVQSLKIGLMSLSKG 2966
Score = 114 bits (285), Expect = 4e-24
Identities = 480/2732 (17%), Positives = 1041/2732 (38%), Gaps = 482/2732 (17%)
Query: 6235 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP-DVLSQELGMEGEKS---S 6290
++ ++E E+ ++S A E + AET E D+ S ++ +E + S
Sbjct: 271 RKYKKECEEEAINIQSTAPEEEH---ESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLS 327
Query: 6291 AEDQMRMK------WESLHQEFSTKQKLLQNVL-EQEQEQVLYSRPNRLLSGVPLYKGDV 6343
AED + + E + +F+T + + + Q + N+L++ +G +
Sbjct: 328 AEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLIT-----QGTL 382
Query: 6344 PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS------IHLEQKLYDGVSATSTWLDDV 6397
+++ + + LN +E + +S RQS + L++K +SA WL
Sbjct: 383 SDEEEFEIQEQMTLLNARWEALRVES--MDRQSRLHDVLMELQKKQLQQLSA---WLTLT 437
Query: 6398 EERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPE----NGDNRDV 6453
EER+ ++ ETC + D+K + + ++++K+L S E N V
Sbjct: 438 EERI--------QKMETCPLDD-----DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMV 484
Query: 6454 I-------EDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYI 6506
+ E L +L L C +ER ++ ++ +L+ L + + +
Sbjct: 485 VIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL----QEINILWQELLEEQCL 540
Query: 6507 ILQKLANVFEQPVAEQIEAIQQAEDG----LKEFDAGIIELKRRGDKLQVEQPSMQELSK 6562
+ L E+ EA+ + + KE + L + +++++ ++ +LS+
Sbjct: 541 LKAWLT--------EKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSE 592
Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
+ +L+ + + + + L +++ +Q L D + +A + K+
Sbjct: 593 IGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDL 652
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
++ + + + + + + ++ I ++ + +F + +LK K +
Sbjct: 653 LETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILK--WKTAI 710
Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESS----IPSVGLVEENEDRLIDRITLYQHLKSS 6738
+ I E +D E+ ++L+ +E IP + + L++++ K
Sbjct: 711 QTTEIKEYMKM--QDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMG-----KEG 763
Query: 6739 L--NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILK- 6795
L E + L +V + K +S DLE ++ QL E + N K+L LE ++K
Sbjct: 764 LPTEEIKNVLEKVSSEWKN--VSQHLEDLERKI-QLQE----DINAYFKQLDELEKVIKT 816
Query: 6796 --HWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQS 6853
W ++ S S L S KD + + + ++EM R +A + D
Sbjct: 817 KEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQ 876
Query: 6854 SLKSSVLSTGNQLLRLKKVDTATLRSELS-RIDSQWTDLLTNIPAV---QEKLHQLQMDK 6909
S L + + L +EL + + + L + V E Q+ ++
Sbjct: 877 RGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNV 936
Query: 6910 LPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDF 6969
L + + + ++ +++ + A+H+ ++ K + +++
Sbjct: 937 LNDLAKVEKALQEKKTLDEILENQKP---------ALHKLAEETKALEKNVH-------- 979
Query: 6970 VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYEN 7029
DVE + K +F + G NK L+ LV++ + LLE + + +E
Sbjct: 980 ----------PDVE--KLYKQEFDDVQGKWNK----LKVLVSKDLHLLEEIALTLRAFEA 1023
Query: 7030 NVQCLKTWFE-TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 7088
+ ++ W + ++ +KQQ GD A +Q L C + I+ E ++ +++ L
Sbjct: 1024 DSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNL 1083
Query: 7089 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7148
+ + V + L + L + K L ++ ++ K ++ ++ +
Sbjct: 1084 RSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQ 1143
Query: 7149 ARYSLSRFRLLTGSLEAVQVQVDNLQNLQDD-LEKQERS--------------------- 7186
A S E ++ V+ ++ ++D L+K+ R
Sbjct: 1144 AEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQEL 1203
Query: 7187 -------LQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLE----------EIAE 7229
L+ + + N++ +CH TL+EV W LL + E
Sbjct: 1204 TSELNVVLENYQLLCNRIRGKCH---------TLEEVWSCWIELLHYLDLETTWLNTLEE 1254
Query: 7230 QLQSSKALLQLWQRYKDYSKQCASTVQQQED---RTNELLKAATNKDIADDEVATWIQDC 7286
+++S++ L + + + S ++ D + EL + + I DD ++ ++
Sbjct: 1255 RMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAF 1314
Query: 7287 NDLLKGLG--------TVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE- 7337
N + L +++ L L E +Q+ Q + S + L+ + A +
Sbjct: 1315 NSRYEDLSHLAESKQISLEKQLQVLRET-DQMLQVLQESLGELDKQLTTYLTDRIDAFQV 1373
Query: 7338 -QALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE--------EILQGQDPSHSSDLST 7388
Q K Q + A L E +++ + E+ ++LQ + S+
Sbjct: 1374 PQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQL 1433
Query: 7389 IQ------ERMEELKG---------QMLKFSSMAPD-----LDRLNELGYRLPLNDKEIK 7428
Q +RM + K +L + PD LD+ +L L E++
Sbjct: 1434 FQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVE 1493
Query: 7429 RMQNLNRHWSLISSQTTER--------------FSKLQSFLLQHQTFLEKCETWMEFLVQ 7474
+ RH ++ Q T+ ++ L + + + + LE+ + +
Sbjct: 1494 TVIKTGRH--IVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKK 1551
Query: 7475 TEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFN 7534
L+ +S L+++ + L ++ + +++ D LE+ + D +
Sbjct: 1552 EAASLSEWLSATETELVQKSTSEGLL-GDLDTEISWAKNVLKD----LEKRKAD-LNTIT 1605
Query: 7535 LKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE-VSYLPM--SGLG 7591
L N +G ++R ++++ W R R E L+ + L + +
Sbjct: 1606 ESSAALQNLIEGSEPILEERLCVLNAG---WSRVRTWTEDWCNTLMNHQNQLEIFDGNVA 1662
Query: 7592 SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE----L 7647
+ L QA L DE++ +K +Q+ E K+L+ D +A LQ E
Sbjct: 1663 HISTWLYQAEALLDEIE--KKPTSKQE-------EIVKRLVSELD---DANLQVENVRDQ 1710
Query: 7648 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE-E 7706
A I + +S R E + KLA L +++EK + I + KL ++ L Q L E
Sbjct: 1711 ALILMNARGSSSR-ELVEPKLAELNRNFEKVSQHIKSA--KLLIAQEPLYQCLVTTETFE 1767
Query: 7707 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNE---RVELLQRQWEE 7763
++LEN + + +LK S+D+ ++E ++E + ++ EE
Sbjct: 1768 TGVPFSDLEKLENDIEN---------MLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEE 1818
Query: 7764 LCHQ---------LSLRRQQIGERLNEWAVFSEKNKEL-------------CEWLTQMES 7801
+ HQ + L+ + R N+ + +++ ++L ++
Sbjct: 1819 MLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINK 1878
Query: 7802 KVSQNGDILIEEMIEKLKKDYQEEIAIAQEN----KIQLQQMGERLAKASHESK------ 7851
+ D+ + + +L E+ + +++ K QL ++GE++A HE +
Sbjct: 1879 ILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIA-VIHEKQPDVILE 1937
Query: 7852 -----ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 7906
A +I L ++N +W + + + R + +Q +++ L W+ E
Sbjct: 1938 ASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEE 1997
Query: 7907 ELAKPIVYDSC---NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7963
++ D+C S ++++ QQEL+ I H A++ + ++ +
Sbjct: 1998 -----LLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKL----SQ 2048
Query: 7964 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 8023
A+ +++ L++RW I A +R+ +++ + K+ WL +E
Sbjct: 2049 ADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ 2108
Query: 8024 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL----- 8078
S+ T E L++ +++ +L+ +N R E +D + SL
Sbjct: 2109 KRST-----TELGENLQELRDLTQEMEVHAEKLKWLN----RTELEMLSDKSLSLPERDK 2159
Query: 8079 -KQMVHEGNQRWDNLQKRVTSILRRL-------------KHFIGQREEFETARDSILV-- 8122
+ + N W+ + + V + L+ H Q+ ++ I V
Sbjct: 2160 ISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQS 2219
Query: 8123 ---------------------WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLN 8159
WL +D L +NI + + + + ++K + ++
Sbjct: 2220 HRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQR 2279
Query: 8160 HNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD- 8217
H +++ + + L K+ D I E+L+ ++ VE ++L + +
Sbjct: 2280 HPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSL 2339
Query: 8218 --DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL---------------S 8260
D+H EL + A L L R L+ Q S N L +
Sbjct: 2340 QWDDHREETEELMRKYEARLYILQQARRDP---LTKQISDNQILLQELGPGDGIVMAFDN 2396
Query: 8261 LAQPLRSERSGRDT---PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 8317
+ Q L E DT + + + W + D ++A+ + +D ++F
Sbjct: 2397 VLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFL 2456
Query: 8318 ---------LRGAVGLSGDHSALESQI--RQLGKALDDSRFQIQQTENIIRSKTPTGPEL 8366
+ V S +AL+ I R+L + + D + +I +I +S +
Sbjct: 2457 KWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKS-------I 2509
Query: 8367 DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQA 8426
D + + +K LG + L+H+L + + RW L+A
Sbjct: 2510 DGNRQKMVKALGNS----EEATMLQHRLDDMNQ--------------------RWNDLKA 2545
Query: 8427 QALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK 8486
++ S ++ + +KW + L + WL +EEL+ +++ + D+ ++LQ K
Sbjct: 2546 KSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELK--KQMPIGGDVPALQLQYDHCK 2603
Query: 8487 ELQK-----------AVDHRKAIILSINLCSPEFTQAD-------------SKESRDLQD 8522
L++ AVD + + + +PE + + K ++ ++
Sbjct: 2604 ALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRK 2663
Query: 8523 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSN 8582
+ S++ +W+ + ++ W+ + AL + + L ++ + +N P+ +
Sbjct: 2664 QSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPV-GD 2722
Query: 8583 LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 8642
L + LQDH +++M + E+ +V ++ D+S Q L + L+ ++ + R
Sbjct: 2723 LLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQ-LSPLDLHPSLKMSRQLDDLNMRW 2781
Query: 8643 KLLLKEVSRHIKELEKL-LDVSSSQQDLSSWS 8673
KLL V +K+L++ D S Q S S
Sbjct: 2782 KLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTS 2813
Score = 67.4 bits (163), Expect = 6e-10
Identities = 198/1080 (18%), Positives = 416/1080 (38%), Gaps = 159/1080 (14%)
Query: 7750 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI 7809
+ E++ LL +WE L + R+ ++ + L E + ++ ++L WLT E ++ +
Sbjct: 390 IQEQMTLLNARWEALRVESMDRQSRLHDVLME--LQKKQLQQLSAWLTLTEERIQKMETC 447
Query: 7810 LIEEMIEKLKKDYQEEIAI-----AQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVN 7863
+++ ++ L+K +E ++ A++ K+ L M + + S ES + +E +L K+
Sbjct: 448 PLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLG 507
Query: 7864 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQ 7923
+RW + R +L+E + Q+L + L+ WL E L K + + +E+
Sbjct: 508 ERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELS 567
Query: 7924 RKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDS-IQQATRNLDRRWRN 7982
+ L+ D+E L+ + D +++ I + L +RW +
Sbjct: 568 VSVRRLAILKEDMEMKR----QTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDS 623
Query: 7983 ICAMSMERRLKIEETW------RLWQKFLDDYSRFEDWL---KSSERTAAFPSSSGVIYT 8033
+ + ++ + ++ QK L + R + KS + P
Sbjct: 624 LVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIH 683
Query: 8034 VAKEELKKFEAFQRQVHECL----TQLELIN-KQYRRLARENRTDSACSLKQMVHEGNQR 8088
V E KKF+A ++ + T ++ K+Y ++ ++ ++ LK + E +R
Sbjct: 684 VDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKM--QDTSEMKKKLKALEKEQRER 741
Query: 8089 W---DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC--DVQ 8143
D L + ++ ++ EE + + + + L ++E + D+
Sbjct: 742 IPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDIN 801
Query: 8144 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV 8203
A KQL +++E++I E+ ++ + +++ + L L+ CQ +
Sbjct: 802 AYFKQL-----------DELEKVIKTKEEWVKHTSISESS--RQSLPSLKDSCQRELTNL 848
Query: 8204 ERYHKK----------LIRLPLPDD----------------EHDLSDRELELEDSAALSD 8237
H K L+ P D + + DR+ LE+
Sbjct: 849 LGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQP 908
Query: 8238 LHWHDRSA----DSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD--YDL 8291
H + + D L + + +SL++ L ++D I LE + L
Sbjct: 909 GHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEI-LENQKPALHKL 967
Query: 8292 SRDLESAMSRALPSED----EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRF 8347
+ + ++ P + +E D + + + V +S D LE +I +A +
Sbjct: 968 AEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLE-EIALTLRAFEADST 1026
Query: 8348 QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 8407
I++ + ++ G + L +CS+ ++ ++ +E LK +E NL
Sbjct: 1027 VIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE---TNL 1083
Query: 8408 HS---------TETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGD 8458
S +T+ + E L + +++ R+ ++ +K DL + W+
Sbjct: 1084 RSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQ 1143
Query: 8459 TEEE-LEQLQRLELSTDIQTIELQIKKLKE--LQKAV------DHRKAIILSINLCSPEF 8509
EEE LE+ + ++++ ++K+ KE LQK V D+ K + + E
Sbjct: 1144 AEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQEL 1203
Query: 8510 TQADSKESRDLQDRLSQMNGRWDRVCSLLEE-----------------WRGLLQDALMQC 8552
T + + Q +++ G+ C LEE W L++ +
Sbjct: 1204 TSELNVVLENYQLLCNRIRGK----CHTLEEVWSCWIELLHYLDLETTWLNTLEERMKST 1259
Query: 8553 QGFHEMSHGLLLMLENIDR-------RKNEIVPIDSNL-DAEILQDHHKQLMQIKHELLE 8604
+ E + + LE+++ + +I + L D IL D ++ K E
Sbjct: 1260 EVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDD----IISEKLEAFN 1315
Query: 8605 SQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 8664
S+ S S Q+ + + E + + V+ L L K+++ ++ + V
Sbjct: 1316 SRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQ 1375
Query: 8665 SQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGS 8724
Q + + SA EL T N + P ++SP SR+ +GGS
Sbjct: 1376 EAQKIQAEISAHEL--------TLEELRRNMRSQP------------LTSPESRTARGGS 1415
Score = 46.6 bits (109), Expect = 0.001
Identities = 59/289 (20%), Positives = 133/289 (46%), Gaps = 32/289 (11%)
Query: 8383 SIDSVKRLE-----HKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQ 8437
+ID+++ +E +K + EEE+ +N+ ST + + E +A+ S +
Sbjct: 259 TIDAIREVETLPRKYKKECEEEA----INIQSTAPE-----EEHESPRAETPSTVTEVDM 309
Query: 8438 NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKA 8497
+L +Q L + WL E+ ++ ++S D++ ++ Q + + ++
Sbjct: 310 DLDSYQ---IALEEVLTWLLSAEDTFQEQD--DISDDVEEVKDQFATHEAFMMELTAHQS 364
Query: 8498 IILSI----NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 8553
+ S+ N + T +D +E ++Q++++ +N RW+ + + + L D LM+ Q
Sbjct: 365 SVGSVLQAGNQLITQGTLSDEEEF-EIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQ 423
Query: 8554 --GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA-EILQDHHKQLMQIKHELLESQLRVA 8610
++S L L E I +K E P+D ++ + + L + HK L + +L Q++V
Sbjct: 424 KKQLQQLSAWLTLTEERI--QKMETCPLDDDVKSLQKLLEEHKSL---QSDLEAEQVKVN 478
Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 8659
SL M + N+ + ++++ +G R + + L+++
Sbjct: 479 SLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEI 527
>gi|145580592 nesprin-3 [Homo sapiens]
Length = 975
Score = 285 bits (729), Expect = 1e-75
Identities = 193/751 (25%), Positives = 370/751 (49%), Gaps = 15/751 (1%)
Query: 2624 QEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM 2683
Q + + +++ W+KA+QD+L ++T G + LE RL + + I ++ EG V++++
Sbjct: 4 QPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDL 63
Query: 2684 AIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKN 2743
+ E L + + I +L+ +K W + ++ H S +E V W++Y+ ++
Sbjct: 64 VLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARD 123
Query: 2744 QLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEK 2803
+ +W + + +E ++ Q GLKEK L H Q +L ++ L RL+ ++ L+ +
Sbjct: 124 EFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183
Query: 2804 TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
D S + AQ+ +K +++ + A++++ +E++ ++H Y V EF WL + E++
Sbjct: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKV 243
Query: 2864 HRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEM 2923
+ + TQ +LS ++++ G L +E + V +NT+ G E + E+
Sbjct: 244 NGCLGRNCKLPITQ-RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGEL 302
Query: 2924 QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ- 2982
+ +R ++ + + L L+ EQ Q+ QLE L +F +L+ AQ+
Sbjct: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQ----QIKQLEAELSEFRMVLQRLAQEG 358
Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
L T++E+V W + AL EPR + L++QL EL F +L S V
Sbjct: 359 LQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIA 418
Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
I+EY L +++++ L Q F++ +D Q W A+ +P ++ + T
Sbjct: 419 TIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-DLPSLHT 477
Query: 3103 SLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH 3162
L +I+ L ES + L M+ K +LL + +E+A + +V + D H++L
Sbjct: 478 FLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLL 537
Query: 3163 QKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEE 3222
Q++S L++L Q KDF + EP+Q L + V DLP K+ + +LQ + EE
Sbjct: 538 QRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEE 597
Query: 3223 IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEH 3282
Q+ + Q+ + + +H++ QLSS + AL ++ V R + V EH
Sbjct: 598 GLDLGAQMEAARPLVQE-------NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEH 650
Query: 3283 NQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3342
FS + EL+ W+ L+++ + +S+ + E L++ EKE Q+ ++
Sbjct: 651 CTFSHQLLELRQWIVVTTQKLEAH-RGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASL 3373
+G V++ +SPEG +Q++L+ + + W +L
Sbjct: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRAL 740
Score = 118 bits (296), Expect = 2e-25
Identities = 137/687 (19%), Positives = 285/687 (41%), Gaps = 42/687 (6%)
Query: 3283 NQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3342
+ F +++ Q WM L + ++ L++R + E + ++ E +++ +++
Sbjct: 7 DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
E++L + P I +L+ +K W ++ C S++E W+ Y +F
Sbjct: 67 MAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFY 126
Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3462
W M L L++K L A++L V + + LL+ + + A +
Sbjct: 127 RWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGD 186
Query: 3463 QLELQDLQER----YRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY 3518
+D Q+R Y A++ +A++ V E++ R H+EYQ + F++WL EK++
Sbjct: 187 PSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVN-- 244
Query: 3519 SVLEGDAHTHET-TLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAED-------- 3569
L + T L LQ++ G+ L ++ VI + P +
Sbjct: 245 GCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEE 304
Query: 3570 --RALESLRQDWQAYQHRLS---ETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPR 3624
+ LE LR W+ + RL +R + + +L +F+ V + + A+E + P
Sbjct: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQ--RLAQEGLQPA 362
Query: 3625 TRRQSNRATKEIQLHQMKKWHEEVTAYRDE---VEEVGARAQEILDESHVNSRMGCQATQ 3681
+ T++ + +++ A E V+ + A+ +E++ H +
Sbjct: 363 AK----AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIA 418
Query: 3682 LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
YQ+L ++ E+ + + L W + + A+ D
Sbjct: 419 TIQEYQSLKVKSARLRNAAAVEL--WQHFQRPLQDLQLWKALAQRLLEVTAS---LPDLP 473
Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
+ L +E L + + LL + K + + + A L +++ M L
Sbjct: 474 SLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLH 533
Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
+++ + L+ L K+F + L + + + Q + + + +L K+AQLS+ +
Sbjct: 534 NSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593
Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQD-VTLKDKIDQLQSDYQDLCSIGKEHVFSLEAK 3920
LQ+ L + + EA LVQ+ + K+DQL SD+Q L ++ V
Sbjct: 594 LQEEGL-------DLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQS 646
Query: 3921 VKDHEDYNSELQEVEKWLLQMSGRLVA 3947
V++H ++ +L E+ +W++ + +L A
Sbjct: 647 VQEHCTFSHQLLELRQWIVVTTQKLEA 673
Score = 90.9 bits (224), Expect = 5e-17
Identities = 184/968 (19%), Positives = 385/968 (39%), Gaps = 104/968 (10%)
Query: 3496 EYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHT 3555
++ R ++ + W+ Q++L +G E L + +++ EG+ ++ VL
Sbjct: 8 DFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRM 67
Query: 3556 REDVI---PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVV---NKLRLMEQKFQQ 3609
E ++ P L+ ++ W+ ++ ++ V ++ L +F +
Sbjct: 68 AEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR 127
Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
W + + P Q K+ QL H +V + V+ +L+E+
Sbjct: 128 ---WFQKMMVTLEPHIELQLGLKEKQWQLS-----HAQVLLHN--VDNQAVLLDRLLEEA 177
Query: 3670 -HVNSRMGCQAT------QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYG 3722
+ +R+G + ++ + Y A+ + +++ LE+ + EE ++ + + W
Sbjct: 178 ASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLK 237
Query: 3723 STHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE 3782
+ + + K+ ++L TL+ + KD +G L++ E+ ++
Sbjct: 238 AVVEKVNGCLGRNCKLPIT---QRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLG 294
Query: 3783 AERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3842
AE++ E+ + + L++L + +E L L + + K L ++E++ +L
Sbjct: 295 AEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRL 354
Query: 3843 EEPKMELYEKK-------AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT-LKD 3894
+ ++ K A +Y + + + S EP V ++ + + L+ ++ L D
Sbjct: 355 AQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSD 414
Query: 3895 KIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKW------LLQMSGRLVAP 3948
+ +YQ L K A V+ + + LQ+++ W LL+++ L P
Sbjct: 415 SVIATIQEYQSLKV--KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASL--P 470
Query: 3949 DLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHA 4008
DL SL T Q+ +A + E + ++ L LQ+K D LIG L + V
Sbjct: 471 DL---PSLHTFLPQI---EAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAG 524
Query: 4009 HLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQ----CQAWLSA---VQPDLEP 4061
++ ++++ ++ QSL + + + + LQ+ Q + A +Q DL P
Sbjct: 525 SMRDRDLLHNSLLQRKSKL-QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDL-P 582
Query: 4062 SPQPPLSRAEAIKQV-KHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQ 4120
Q LSR + +++ A E AR L + + D Q ++++E
Sbjct: 583 GKQAQLSRLQGLQEEGLDLGAQMEAARP----LVQENPNHQHKMDQLSSDFQALQRSLED 638
Query: 4121 KLVQAQNLTQGWEEIKHLKSEL--WIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
+ + + Q H EL WI + Q ++ E A++ ++ +
Sbjct: 639 LVDRCRQSVQEHCTFSHQLLELRQWIVV-----TTQKLEAHRGEAGPGDAESQEAEFERL 693
Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
V + K+A + +++E L ++ SPE + + ++ +L L L E L
Sbjct: 694 VAEFPEKEAQL-SLVEAQGWLVMEKSSPEGAAV--VQEELRELAESWRALRLLEESLLSL 750
Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVH-LEALKKLALALQERKYAIEDLKD 4297
R++H + +EV K +N+ +S + + ++ A LQE + + ED
Sbjct: 751 IRNWH--LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQ 808
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
+ + L +++ +LV R I + + E+L +S+ QEL
Sbjct: 809 LLRNFGQWLQVENSKLV-------------------RIIAMRTSTAEDLRTRKSKLQELE 849
Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
E Q L+ P + L +L + ML KS +KD+ ++
Sbjct: 850 ARVPEGQHLFENLLRLGPARGTSDEL--------EDLRYQWMLYKSKLKDSGHLLTQSSP 901
Query: 4418 NERQVIQK 4425
E QK
Sbjct: 902 GEPTGFQK 909
Score = 72.4 bits (176), Expect = 2e-11
Identities = 103/382 (26%), Positives = 157/382 (41%), Gaps = 49/382 (12%)
Query: 8427 QALSKEL-----RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 8481
QAL + L R +Q++Q+ F+ L + W+ T ++LE + D ++ E +
Sbjct: 630 QALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAE 689
Query: 8482 IKKL------KELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8535
++L KE Q ++ + ++ + SPE +E R+L + + + +
Sbjct: 690 FERLVAEFPEKEAQLSLVEAQGWLV-MEKSSPEGAAVVQEELRELAESWRALRLLEESLL 748
Query: 8536 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8595
SL+ W Q S ++ NI + I P+D + H ++
Sbjct: 749 SLIRNWH---------LQRMEVDSGKKMVFTNNIPKSGFLINPMDP------IPRHRRRA 793
Query: 8596 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8655
++ E S +D S QLL N +E + V +I R +R K
Sbjct: 794 NLLQEE-------EGSHEDFS-QLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKL 845
Query: 8656 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8715
E V Q + L G TS R + K L G ++
Sbjct: 846 QELEARVPEGQHLF------ENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQ- 898
Query: 8716 HSRSTKGGSDSSLSEPGPGRSGRGFLFR-VLRAALPLQLLLLLLIGLACLVPMSEEDYSC 8774
+ G + + R G G LFR ALPLQLLLLL + L L+P+ EED SC
Sbjct: 899 ----SSPGEPTGFQKTRRWR-GLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSC 953
Query: 8775 ALSNNFARSFHPMLRYTNGPPP 8796
L+NNFARSF MLRY NGPPP
Sbjct: 954 TLANNFARSFTLMLRY-NGPPP 974
Score = 68.9 bits (167), Expect = 2e-10
Identities = 115/641 (17%), Positives = 250/641 (39%), Gaps = 55/641 (8%)
Query: 2119 EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL---------KKIHSSDFSLVKT 2169
++ +W S + + ++ + LD + L + + +K +++ VK
Sbjct: 147 KEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKA 206
Query: 2170 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW-SNNCVPQMAENISNLD 2228
+ VD V+ + EE + +W + + +++ G NC + + +S L
Sbjct: 207 KAQKRVDLLEQVAREHEEYQAGVD-EFQLW--LKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
Query: 2229 NHL----RAEELLKEFESEVKNKALRLEELHSK--VNDLKELTKNLETPPDLQFIEADLM 2282
+ R EE L+ E + L ++ +L+E+ K LE L E + +
Sbjct: 264 DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERL 323
Query: 2283 QKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEAL--- 2339
+ L ++ E +K A+ ++ + + +E L A+ T + L
Sbjct: 324 RGLLRSRGAWEQQ---IKQLEAELSEFRMVLQRLA------QEGLQPAAKAGTEDELVAH 374
Query: 2340 -KKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSK 2398
++ + L S++ + Q L L H+ L+ L ++ I++++++ ++
Sbjct: 375 WRRYSATRAALASEEPRVDRLQAQLKELIVFPHN--LKPLSDSVIATIQEYQSLKVKSAR 432
Query: 2399 TQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTG---DSKVLEAKLHDLQNILDS 2455
+ + L +HF +Q+ Q W KA A+ + T D L L ++ L
Sbjct: 433 LRNAAAVELWQHFQRPLQDLQLW----KALAQRLLEVTASLPDLPSLHTFLPQIEAALME 488
Query: 2456 VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCAS 2515
S + L + + L ++ +++ EQ+ + + L+ K LQ +
Sbjct: 489 SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLA 548
Query: 2516 ELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLD 2575
+ F L + +++ R E ++ +P K+ ++ +++ E L ++
Sbjct: 549 QHKDFGAAFEPLQRKLLDLQVRVQAEK--GLQRDLPGKQAQLSRLQGLQEEGLDLGAQME 606
Query: 2576 KLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQS 2635
Q H QL + Q L R ++ + C+ ++QEH L
Sbjct: 607 AARPLVQENPNHQH-------KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659
Query: 2636 MWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSS 2695
+ W+ +L G D E + ++ + ++ E E +L++ +G + S
Sbjct: 660 LRQWIVVTTQKLEAHRGEAGPGDA-ESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKS 718
Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
+ EG V+Q +L L E W + + +L S+I W+
Sbjct: 719 SPEGAAVVQEELRELAESWRALRL----LEESLLSLIRNWH 755
Score = 65.1 bits (157), Expect = 3e-09
Identities = 163/863 (18%), Positives = 327/863 (37%), Gaps = 97/863 (11%)
Query: 6879 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIK 6938
+ L I +QW + +T + ++ + + A E W M + E +I+
Sbjct: 85 ARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTL---EPHIE 141
Query: 6939 NSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGA 6998
+G K L + +++ + + +D + + + + + D + +
Sbjct: 142 LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN-----RIGDPSVDEDAQKR 196
Query: 6999 MNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQ 7058
M + ++ +++ LLE + EY+ V + W + +++ + +
Sbjct: 197 MKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPIT 256
Query: 7059 NALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMV 7118
L QD+ E+ +E +E+ +I+N + + L E+ + L +
Sbjct: 257 QRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALW 316
Query: 7119 GQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF-------RLLTGSLEAVQVQVD 7171
+ + L+ +L + + ++ + L E R L R G+ + +
Sbjct: 317 EEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWR 376
Query: 7172 NLQNLQDDLEKQERSLQKFGSITNQLLKECH--PPVTETLTNTLKE--------VNMRWN 7221
+ L +E + + + +L+ H P+++++ T++E +R N
Sbjct: 377 RYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLR-N 435
Query: 7222 NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL--LKAATNKDIADDEV 7279
E+ + Q LQLW+ + +++ L ++AA + E+
Sbjct: 436 AAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKEL 495
Query: 7280 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7339
T +Q DLL G+ F E L +QV A +++ L L +
Sbjct: 496 LTMLQLKKDLLIGI--------FGQERATALLEQV----AGSMRDRDL--------LHNS 535
Query: 7340 LCKQQTSLQAGVLDYETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERM 7393
L ++++ LQ+ + ++ F + E L+ + V+AE+ LQ P + LS +Q
Sbjct: 536 LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQ 595
Query: 7394 EELKGQMLKFSSMAPDLDRLNELGYRLPL---NDKEIKRMQNLNRHWSLISSQTTERFSK 7450
EE LD ++ PL N +M L+ + + + +
Sbjct: 596 EE-------------GLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDR 642
Query: 7451 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAH-ELFQAEMFSRQQ 7509
+ + +H TF + +++V T QKL E Q A E AE ++
Sbjct: 643 CRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEA 702
Query: 7510 ILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYR 7569
L + G ++E+ + +L L+ W+ +R ++ + S IR W R
Sbjct: 703 QLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWR-ALRLLEES---LLSLIRNWHLQR 758
Query: 7570 EMAEKLRKWLVEVSYLPMSGL---GSVPIPLQQAR-TLFDEVQFKEKVF---LRQQGSYI 7622
+ +K +V + +P SG PIP + R L E + + F LR G +
Sbjct: 759 MEVDSGKK-MVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQW- 816
Query: 7623 LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKC--EK 7680
L VE K + + A++ AE KS LE + + L ++ + +
Sbjct: 817 LQVENSKLVRI-------IAMRTSTAEDLRTRKSKLQELEARVPEGQHLFENLLRLGPAR 869
Query: 7681 GIADSLEKLR----TFKKKLSQS 7699
G +D LE LR +K KL S
Sbjct: 870 GTSDELEDLRYQWMLYKSKLKDS 892
Score = 60.5 bits (145), Expect = 7e-08
Identities = 152/842 (18%), Positives = 315/842 (37%), Gaps = 104/842 (12%)
Query: 2815 EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSS 2874
+++K Q+ + +T ++E + YL A EF W L ++
Sbjct: 88 KDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLK 147
Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
Q +LS + L+ + + A L R+ A + + + ++A++
Sbjct: 148 EKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVD--EDAQKRMKAEY---- 201
Query: 2935 DSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEE 2994
D+V +L+ Q+A +E+ V ++F LK +++ G+N
Sbjct: 202 DAVKAKAQKRVDLLEQVAREHEEYQAGV-------DEFQLWLKAVVEKVNGCLGRNCKLP 254
Query: 2995 IVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQA 3054
I + Q+I + E E L+ Q + R + L + K++G ++E + L+
Sbjct: 255 ITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLG--AEKITGELEEMRKV-LEK 311
Query: 3055 SKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTS-LQKIQEFLSE 3113
+ +E+ +R R R W K A+ + + ++ LQ + +E
Sbjct: 312 LRALWEEEE---ERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTE 368
Query: 3114 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3173
E H ++ L S ++ + ++ + K ++ ++LK+
Sbjct: 369 DELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKV 428
Query: 3174 QMKDFEVSA---------EPIQD---WLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLE 3221
+ +A P+QD W + ++++ +++ L DLP+ ++++ L
Sbjct: 429 KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTAS-LPDLPSLHTFLPQIEAALM 487
Query: 3222 EIHCYEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIV 3279
E + L L+ K L GQ + + +V+ L N ++ S+L ++
Sbjct: 488 ESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLL 547
Query: 3280 AEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKM 3339
A+H F + LQ + D + + D ++ +L+ L QE+ + +
Sbjct: 548 AQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGL----QEEGLDLGA 603
Query: 3340 IVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVR 3399
+ ++Q +P + Q + + SL RC+ ++ + ++ +
Sbjct: 604 QMEAARPLVQE-NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTFSHQLL 658
Query: 3400 QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEH 3459
+ W+ L E+ R A D + + + L E + L +E +G + E
Sbjct: 659 ELRQWIVVTTQKL-EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEK 717
Query: 3460 Y------VTQLELQDLQERYRAIQ--ERAKEAVTKSEKLVRL------------------ 3493
V Q EL++L E +RA++ E + ++ ++ L R+
Sbjct: 718 SSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSG 777
Query: 3494 -------------------------HQEYQRDLKAFEVWLGQEQEKLDQYSVLE-GDAHT 3527
H+++ + L+ F WL E KL + + A
Sbjct: 778 FLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAED 837
Query: 3528 HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLS 3587
T LQEL+ EGQ H E+++ G + LE LR W Y+ +L
Sbjct: 838 LRTRKSKLQELEARVPEGQ-------HLFENLLRLGPARGTSDELEDLRYQWMLYKSKLK 890
Query: 3588 ET 3589
++
Sbjct: 891 DS 892
Score = 60.5 bits (145), Expect = 7e-08
Identities = 159/775 (20%), Positives = 294/775 (37%), Gaps = 146/775 (18%)
Query: 6995 QLGAMNKSWQ-----ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 7049
QLG K WQ +L V + LL+ LLE + N
Sbjct: 143 QLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN-------------------- 182
Query: 7050 RIGDQASVQNALKDCQDLEDLIKAK-EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELG 7108
RIGD + ++A K + D +KAK +K V+ +EQ RE
Sbjct: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQ-------------------VAREHE 223
Query: 7109 QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQV 7168
+ A +D + ++ LK+V++ K+N L +
Sbjct: 224 EYQAGVD----EFQLWLKAVVE----------KVNGCLGR------------NCKLPITQ 257
Query: 7169 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNM---RWNNLLE 7225
++ LQ++ D + E SL+ + +++ P E +T L+E+ + L E
Sbjct: 258 RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE 317
Query: 7226 EIAEQLQSSKALLQLW-QRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7284
E E+L+ W Q+ K + + + E L+ A D+ VA W +
Sbjct: 318 EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRR 377
Query: 7285 DCN------------DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQH 7332
D L+ +K+ + F H L + + S + IQ Q SL
Sbjct: 378 YSATRAALASEEPRVDRLQA--QLKELIVFPHNL-----KPLSDSVIATIQEYQ-SLKVK 429
Query: 7333 LCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQER 7392
L A A V ++ F + L+ L+ W A+ +L+ + DL ++
Sbjct: 430 SARLRNA---------AAVELWQHFQRPLQDLQLWKALAQRLLEVT--ASLPDLPSLHTF 478
Query: 7393 MEELKGQMLKFSSMAPDLDRLN-ELGYRLPLNDKE-----IKRMQNLNRHWSLISSQTTE 7446
+ +++ +++ S + L L + + + +E ++++ R L+ + +
Sbjct: 479 LPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQ 538
Query: 7447 RFSKLQSFLLQHQTF------LEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF 7500
R SKLQS L QH+ F L++ ++ VQ E+ L ++ G L Q E
Sbjct: 539 RKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQE-- 596
Query: 7501 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7560
+ + Q + V + K+ LS+ +Q + R +
Sbjct: 597 -----------EGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQ 645
Query: 7561 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV-PIPLQQARTLFDEV--QFKEKVFLRQ 7617
+++ + +LR+W+V + + G P + F+ + +F EK
Sbjct: 646 SVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEK----- 700
Query: 7618 QGSYILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWE 7676
+ + VEA L++ S AA +Q EL E+ E W+ ++RL E+ L L+++W
Sbjct: 701 -EAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWR--ALRLLEE--SLLSLIRNWH 755
Query: 7677 KCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQL 7731
+ + + T S L + + + + R L+ GS +D +QL
Sbjct: 756 LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGS-HEDFSQL 809
Score = 58.5 bits (140), Expect = 3e-07
Identities = 142/799 (17%), Positives = 309/799 (38%), Gaps = 75/799 (9%)
Query: 2411 FSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEG 2470
F S+++ Q W + + + + G LEA+L + + I +G+ ++D V +
Sbjct: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
Query: 2471 QTLYAHL---SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
+ L A K + + + I EE ++ C + + SE D+ +
Sbjct: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR- 127
Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
W +M E E + + EK+ ++ ++ L + LD+L + L
Sbjct: 128 --WFQKM--MVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183
Query: 2588 GHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRL 2647
+ ++ + + ++++ + +EHE + + W+KA+ +++
Sbjct: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKV 243
Query: 2648 ACAESTLG--SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQT 2705
LG K + +RLS +QDI GE L + +R+++ G I
Sbjct: 244 ---NGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITG 300
Query: 2706 QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPG 2765
+LE +++V LE + + W + ER L + + +Q+I+ Q +
Sbjct: 301 ELEEMRKV--------------LEKLRALWEEEEERLRGLLRSRGAWEQQIK---QLEAE 343
Query: 2766 LKEKFVLLDHL-QSILSEA-----EDHTRALHRLIAKSRELYEKTEDESFKDTAQ-EELK 2818
L E ++L L Q L A ED A R + +R E + AQ +EL
Sbjct: 344 LSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELI 403
Query: 2819 TQFNDIMTVAKEKMRKVEEI----VKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSG--- 2871
+++ ++ + ++E VK + A E ++L W ++
Sbjct: 404 VFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLL 463
Query: 2872 DSSATQKKLSKIKELIDSREIGASRLSRVESLAP--EVKQNTTAS--GCELMHTEMQALR 2927
+ +A+ L + + E SR++ L ++K++ G E ++ +
Sbjct: 464 EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVA 523
Query: 2928 ADWKQWE---DSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLT 2984
+ + +S+ Q +S L++L++Q ++F L++ L ++
Sbjct: 524 GSMRDRDLLHNSLLQRKSKLQSLLAQ----HKDFGAAFEPLQRKLLDLQVRVQAEKGLQR 579
Query: 2985 LLEGKNTD-EEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGL 3043
L GK + +G ++ ++ A P ++ + +++ + S D + L
Sbjct: 580 DLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDL 639
Query: 3044 IKEYNCLCLQA-SKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAK--CFDIPQNISEV 3100
+ C Q+ + C Q+L+ R QW+V +TT K +
Sbjct: 640 VDR----CRQSVQEHCTFSHQLLELR---------QWIV---VTTQKLEAHRGEAGPGDA 683
Query: 3101 STSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSN 3160
+ + + ++E + +L+++ ++G L+ + E A +Q ++ E W+
Sbjct: 684 ESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLL 743
Query: 3161 LHQKESALENLKIQMKDFE 3179
S + N +Q + +
Sbjct: 744 EESLLSLIRNWHLQRMEVD 762
Score = 58.2 bits (139), Expect = 4e-07
Identities = 143/777 (18%), Positives = 288/777 (37%), Gaps = 92/777 (11%)
Query: 2848 AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEV 2907
+V + W+ + +++L + G +A + +L + +++ G R+ V +A +
Sbjct: 12 SVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMAEAL 71
Query: 2908 KQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV------SQMALSEQEFSGQ 2961
+ ++ ++A QWE++V C + S+ L+ EF
Sbjct: 72 LACCPGDQKPGILARLKDIKA---QWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
Query: 2962 VAQLEQALE-----QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRT 3016
++ LE Q K W + N D + V +LD L
Sbjct: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAV--------LLDRL------L 174
Query: 3017 EDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR--FRKAFR 3074
E+ S N + D S + EY+ + +A K EQ+ ++ ++
Sbjct: 175 EEAASLFNRI----GDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
Query: 3075 DFQQWLV------------NAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLN 3122
+FQ WL N K+ + Q+I++ ++ E L E G +
Sbjct: 231 EFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNT 290
Query: 3123 MMLSKGELLSTLLTKEKAKGIQAKVTAA-KEDWKNFHSNLHQK---ESALENLKIQMKDF 3178
L ++ L E+ + + K+ A +E+ + L + E ++ L+ ++ +F
Sbjct: 291 SPLGAEKITGEL---EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEF 347
Query: 3179 EVSAEPI-QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA 3237
+ + + Q+ L K E +L A R ++ L EP+++RL+ +
Sbjct: 348 RMVLQRLAQEGLQPAAKAGTED-----ELVAHWRRYSATRAALAS---EEPRVDRLQAQL 399
Query: 3238 QQLWEGQAASKSFRHRVSQLSSQYLALSN---LTKEKVSRLDRIVAEH--NQFSLGIKEL 3292
++L F H + LS +A K K +RL A F +++L
Sbjct: 400 KELIV-------FPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDL 452
Query: 3293 QDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS 3352
Q W A +L+ D L + ++EA L + + M+ + + ++
Sbjct: 453 QLWKALAQRLLEVTAS-LPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFG 511
Query: 3353 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
E + +Q+ L ++ ++ KS+L+ L++ + + ++ +
Sbjct: 512 QERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571
Query: 3413 NESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQER 3472
+ +L K L + + L EE L + +E H Q ++ L
Sbjct: 572 QAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNH---QHKMDQLSSD 628
Query: 3473 YRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY--SVLEGDAHTHET 3530
++A+Q ++ V + + V+ H + L W+ +KL+ + GDA + E
Sbjct: 629 FQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEA 688
Query: 3531 TLRDL------QELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQA 3581
L +E Q+ E Q L E P G ++ L L + W+A
Sbjct: 689 EFERLVAEFPEKEAQLSLVEAQGWL-----VMEKSSPEGAAVVQEE-LRELAESWRA 739
Score = 52.0 bits (123), Expect = 3e-05
Identities = 143/725 (19%), Positives = 270/725 (37%), Gaps = 93/725 (12%)
Query: 5514 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 5573
+A+ R+ L Q A EEY ++ W++ +G + N + ++ Q +
Sbjct: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIA 266
Query: 5574 EESKEIDSELEAMTEKLQYL---TSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDA 5630
++ + LE + E+ + TS EK++ ++ E+ + E+LR + + + L+
Sbjct: 267 KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGL 326
Query: 5631 AKDMKKFEAELKKLQAALEQAQATL-------TSPEVGRLSLKEQLSHRQHLLSEMESLK 5683
+ +E ++K+L+A L + + L P + E ++H + + +L
Sbjct: 327 LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALA 386
Query: 5684 PKVQAVQLCQSALR----IPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ 5739
+ V Q+ L+ P ++ PL + + +E L+ ++ + AA V+
Sbjct: 387 SEEPRVDRLQAQLKELIVFPHNL---KPLSDSVIATIQEYQSLK---VKSARLRNAAAVE 440
Query: 5740 YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLN 5799
Q+ Q QL + + + + + ++ L + + E + +E + L
Sbjct: 441 LWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQ 500
Query: 5800 SKCKML--TMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------ 5851
K +L + AT LL +V G + L LL S S++
Sbjct: 501 LKKDLLIGIFGQERATALL--EQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFE 558
Query: 5852 -RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5910
LL E+G ++ A ++ Q L E L
Sbjct: 559 PLQRKLLDLQVRVQAEKGLQRDLPGKQA----------------QLSRLQGLQEEGLDL- 601
Query: 5911 AAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 5970
A++ + QE P + D Q +L++++ ++++ E + +
Sbjct: 602 GAQMEAARPLVQE--NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659
Query: 5971 SLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEE--- 6027
Q I + +E E+ PG ESQ AE + L+ E E Q SL E
Sbjct: 660 LRQWIVVTTQKLEAHRGEA-GPG-DAESQEAEFERLVAEF-----PEKEAQLSLVEAQGW 712
Query: 6028 LVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQR 6087
LV E ++ P +Q L LAE +R LLEE L + +
Sbjct: 713 LVME--KSSPEGAAVVQEELRELAESWRALR--------LLEESLLSLIRNWHLQ----- 757
Query: 6088 YRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSE----- 6142
R E D + + L P +P+ + N+L E E S+
Sbjct: 758 -RMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRR---ANLLQEEEGSHEDFSQLLRNF 813
Query: 6143 ---LSVHNENL--LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNM---QGTA 6194
L V N L ++ + T ++ KL+ L+ + E Q L + L + +GT+
Sbjct: 814 GQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQH-LFENLLRLGPARGTS 872
Query: 6195 QEKEE 6199
E E+
Sbjct: 873 DELED 877
Score = 51.2 bits (121), Expect = 4e-05
Identities = 113/613 (18%), Positives = 226/613 (36%), Gaps = 39/613 (6%)
Query: 7891 DKNMSSLRTWLAHIESELAKPIVYDSCNSEE--IQRKLNEQQELQRDIEKHSTGVASVLN 7948
D+++ + W+ ++ +L V D+ ++ +L E +++ + + V VL
Sbjct: 10 DRSVEDAQAWMKAVQDQLQ---VNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
Query: 7949 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 8008
+ E LL AC + I +++ +W +IE W W ++L
Sbjct: 67 MAEALL----ACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLAR 122
Query: 8009 SRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR 8068
F W + T P + KE+ + Q +H Q L+++ A
Sbjct: 123 DEFYRWFQKMMVTLE-PHIE--LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAAS 179
Query: 8069 E-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEM 8127
NR + +D ++ + + L+ + EE++ D +WL +
Sbjct: 180 LFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAV 239
Query: 8128 DLQLTN-IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 8186
++ + + + ++ L+ ++ +E + Q +I + PL A I
Sbjct: 240 VEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKIT 299
Query: 8187 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 8246
EL+E+R+ +++ E ++L L + ++LE E S L R A
Sbjct: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVL---QRLAQ 356
Query: 8247 SLLSPQPSSNLSLSLAQPLRSERSGRDTPAS----VDSIPLEWDHDYDLSRDLESAMSRA 8302
L P + L R + R AS VD + + +L+
Sbjct: 357 EGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSV 416
Query: 8303 LPS-EDEEGQDDKDFYLRGAVGLS-GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKT 8360
+ + ++ + K LR A + H Q QL KAL + + +
Sbjct: 417 IATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLE-------VTASL 469
Query: 8361 PTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET---QTAGV 8417
P P L T L E S +K L L+ +++ L G Q AG
Sbjct: 470 PDLPSLHTFLPQIEAALMESS----RLKELLTMLQLKKDLLIGIFGQERATALLEQVAGS 525
Query: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477
+ +LL L ++ +++ L + + F + + L D + ++ + L+ D+
Sbjct: 526 MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQ--RDLPG 583
Query: 8478 IELQIKKLKELQK 8490
+ Q+ +L+ LQ+
Sbjct: 584 KQAQLSRLQGLQE 596
Score = 47.0 bits (110), Expect = 8e-04
Identities = 73/378 (19%), Positives = 145/378 (38%), Gaps = 60/378 (15%)
Query: 1632 LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVK 1691
++ Q+E+ + + +E + HW F W ++ P +++ +
Sbjct: 90 IKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLE-PHIELQLGLKE 148
Query: 1692 VEGELQLIQALQNEVVSQASFYSKLLQLKESLFS-----VASKDDVKMMKLHLEQLDERW 1746
+ +L Q L + V +QA +LL+ SLF+ +D K MK + + +
Sbjct: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAK- 207
Query: 1747 RDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRH 1806
KR++ L+ V EH+++ + F +W+
Sbjct: 208 ------AQKRVDLLEQVAREHEEYQAGVDEFQLWL------------------------- 236
Query: 1807 KDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLA 1866
K ++ + G L + L + L LQ A+D F EE+ + +E +
Sbjct: 237 ----------KAVVEKVNGCLGRNCKLPITQRLSTLQDIAKD-FPRGEESLETLEEQSAG 285
Query: 1867 LSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSL 1926
+ L + ++G L ++R+ +E ++ + E E+ L L++ A E L
Sbjct: 286 VIRNTSPLGAE-KITGELEEMRKVLEKLRALWEEE----EERLRGLLRSRGAWEQQIKQL 340
Query: 1927 DGILSKAQYHLKIGSSE--QRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQ 1984
+ LS+ + L+ + E Q + T D+L R SE + L Q
Sbjct: 341 EAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRL----Q 396
Query: 1985 DQKEELLKSIEDIEERTD 2002
Q +EL+ +++ +D
Sbjct: 397 AQLKELIVFPHNLKPLSD 414
Score = 45.8 bits (107), Expect = 0.002
Identities = 144/812 (17%), Positives = 323/812 (39%), Gaps = 96/812 (11%)
Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
+ F +S+E +AW+ ++ LQ D + + ++ R+ E + K + P+
Sbjct: 7 DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPR-AALEARLWETE----KICQLEPEGRVRV 61
Query: 7415 ELGYRL--------PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 7464
+L R+ P + K + R++++ W + T S+++ L
Sbjct: 62 DLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLH------- 114
Query: 7465 CETWMEFLVQTE------QKLAVEISGNYQHLLE-QQRAHELFQAEMFSRQQILHSIIID 7517
W E+L+ + QK+ V + + + L +++ +L A++ ++++D
Sbjct: 115 ---WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLD 171
Query: 7518 GQRLLEQG----------QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQR 7567
RLLE+ VD+ + +K ++ V +AQ+R +++ R+ +
Sbjct: 172 --RLLEEAASLFNRIGDPSVDEDAQKRMKA-----EYDAVKAKAQKRVDLLEQVAREHEE 224
Query: 7568 YREMAEKLRKWLVEVSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE 7626
Y+ ++ + WL V LG + +P+ Q + ++ K F R + S E
Sbjct: 225 YQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDI---AKDFPRGEESLETLEE 281
Query: 7627 AGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKD---WEKCEKGIA 7683
++ + + EL E+++ + EE++++L LL+ WE+ K +
Sbjct: 282 QSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLE 341
Query: 7684 DSLEKLRTFKKKLSQ------SLPDHHEELHAEQMRCKELENAVGSWTDDLTQL-SLLKD 7736
L + R ++L+Q + +EL A R A+ S + +L + LK+
Sbjct: 342 AELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKE 401
Query: 7737 TLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW- 7795
+ + ++ L++ V ++++ L ++ R + + W F ++L W
Sbjct: 402 LI---VFPHNLKPLSDSVIATIQEYQSL--KVKSARLRNAAAVELWQHFQRPLQDLQLWK 456
Query: 7796 -LTQMESKVSQNGDIL--IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA 7852
L Q +V+ + L + + +++ E + +E LQ + L + +A
Sbjct: 457 ALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRL-KELLTMLQLKKDLLIGIFGQERA 515
Query: 7853 SE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL--AHIESELA 7909
+ +E G + DR L + + R KL+ L + L+ L + +
Sbjct: 516 TALLEQVAGSMRDR-DLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAE 574
Query: 7910 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 7969
K + D + +L QE D+ ++ H D ++D + ++
Sbjct: 575 KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQ--AL 632
Query: 7970 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL-KSSERTAAFPSSS 8028
Q++ +L R C S++ F W+ ++++ A +
Sbjct: 633 QRSLEDLVDR----CRQSVQEHC----------TFSHQLLELRQWIVVTTQKLEAHRGEA 678
Query: 8029 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQR 8088
G A+ + +FE + E QL L+ Q + ++ + A +++ + E +
Sbjct: 679 GP--GDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAES 736
Query: 8089 WDNLQKRVTSILRRLKHFIGQREEFETARDSI 8120
W L+ S+L ++++ QR E ++ + +
Sbjct: 737 WRALRLLEESLLSLIRNWHLQRMEVDSGKKMV 768
Score = 45.4 bits (106), Expect = 0.002
Identities = 82/429 (19%), Positives = 166/429 (38%), Gaps = 64/429 (14%)
Query: 1403 ASEIPLGPQNKQLLQQQAKSIKEQV-----KKLEDTLEEDIKTMEMVKTKWDHFGSNFET 1457
A + P G ++ + L++Q+ + +K+ LEE K +E ++ W+
Sbjct: 266 AKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE-------- 317
Query: 1458 LSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIV--GLEEEAQSFAQFVT 1515
E+E+ L L S A + QI Q++ + E L + GL+ A++ +
Sbjct: 318 ------EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
Query: 1516 TGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSV-SEFEDK 1574
R A T+ EE R + L + F NL+ + SV + ++
Sbjct: 372 VAHWRRYSA--TRAALASEEPRVDR------LQAQLKELIVFPHNLKPLSDSVIATIQEY 423
Query: 1575 LAVPIKIC----SSATETYKVLQEHMDLCQALESLSSAITAFSASA-------------R 1617
++ +K ++A E ++ Q + Q ++L+ + +AS
Sbjct: 424 QSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIE 483
Query: 1618 KVVNRDSCVQEAAALQQQYEDILRR--AKERQTALENLLAHWQRLEKELSSFLTWLERGE 1675
+ S ++E + Q +D+L +ER TAL +A R L + L +
Sbjct: 484 AALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKL 543
Query: 1676 AKASSPEMDISADRVKVEGEL-------QLIQALQNEVVSQASFYSKLLQLKESLFSVAS 1728
+ D A ++ +L Q + LQ ++ + + S+L L+E + +
Sbjct: 544 QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGA 603
Query: 1729 KDDVKMMKLH--------LEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1780
+ + + ++QL ++ L + + ++ + V EH F LL W
Sbjct: 604 QMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQW 663
Query: 1781 IKLFLSELQ 1789
I + +L+
Sbjct: 664 IVVTTQKLE 672
Score = 43.9 bits (102), Expect = 0.007
Identities = 127/632 (20%), Positives = 245/632 (38%), Gaps = 101/632 (15%)
Query: 5103 WHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5162
W +Y AR+E L L+ E + +LS + L+ V++ + L
Sbjct: 115 WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLK-EKQWQLSHAQVLLHNVDNQAVLLDRL 173
Query: 5163 -EEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVK 5221
EE AS + G+ + + M + ++A AQ + +LE E + V
Sbjct: 174 LEEAASLFNRIGDPSVDEDAQKRMKA---EYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
Query: 5222 KATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQD 5281
+ + + +K+ G K + L + + + +L L +Q+ ++++
Sbjct: 231 EFQLWLKAVVEKVNGCLGRNC-KLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRN 289
Query: 5282 GAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQE 5341
+ P ++IT + + EK++ + ++ E + + S W Q+
Sbjct: 290 TS-------PLGAEKITGELEEMRKVLEKLRALWE------EEEERLRGLLRSRGAWEQQ 336
Query: 5342 TKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLA 5401
K+ ++A+L E +++L ++ ++ A+ E L + S A
Sbjct: 337 IKQ--------LEAELSEFRMVLQRLA--QEGLQPAAKAGTEDELVAHW---RRYSATRA 383
Query: 5402 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVV---QA 5458
+A + D++Q ++KE L LK +D+V+ Q
Sbjct: 384 ALASEEPRVDRLQAQLKE---------------------LIVFPHNLKPLSDSVIATIQE 422
Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENR 5518
KV L N+ +EL Q+ L Q+ QL K LA+++ ++T ++ +
Sbjct: 423 YQSLKVKSARLR--NAAAVELWQHFQRPL-QDLQLWKALAQRLLEVTA----SLPDLPSL 475
Query: 5519 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY--------ILHQ 5570
+ L Q + L E + + EL L ++ K L G A+ L EQ +LH
Sbjct: 476 HTFLPQIEAALMESSRLKEL-LTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHN 534
Query: 5571 TLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMI---KIRLQNL 5627
+LL+ ++ S L Q + G E L++ + ++R+Q
Sbjct: 535 SLLQRKSKLQSLLA--------------------QHKDFGAAFEPLQRKLLDLQVRVQAE 574
Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQ 5687
+ +D+ +A+L +LQ E+ E R ++E +H QH +M+ L Q
Sbjct: 575 KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNH-QH---KMDQLSSDFQ 630
Query: 5688 AVQLCQSAL--RIPEDVVASLPLCHAALRLQE 5717
A+Q L R + V H L L++
Sbjct: 631 ALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQ 662
Score = 40.4 bits (93), Expect = 0.078
Identities = 87/448 (19%), Positives = 187/448 (41%), Gaps = 40/448 (8%)
Query: 5346 LGNPTIEIDAQLE---ELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAE 5402
+G+P+++ DAQ E + +A +E++A E +E G+ E L L
Sbjct: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGV-----DEFQLWLKA 238
Query: 5403 VALDLKIRDQIQDKIK-EVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5461
V K+ + K + Q +T Q++++ + + L T L+ ++ V+ +
Sbjct: 239 VVE--KVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLET----LEEQSAGVI--RNT 290
Query: 5462 QKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSK 5521
+ E++ G ++ ++ ++ E+ + + L + G +Q I+Q E LS+
Sbjct: 291 SPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAW----EQQIKQLEAELSE 346
Query: 5522 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5581
L + E L+ K + +++AH W S R + ++ +
Sbjct: 347 FRMVLQRLAQ--EGLQPAAKAGTEDELVAH----WRRYSATRAALASEEPRVDRLQAQLK 400
Query: 5582 ELEAMTEKLQYLT-SVYCTEKMSQQVAELGRETEELRQMIKIRL-QNLQDAAKDMKKFEA 5639
EL L+ L+ SV T Q+ L ++ LR + L Q+ Q +D++ ++A
Sbjct: 401 ELIVFPHNLKPLSDSVIAT---IQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKA 457
Query: 5640 ELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIP 5699
++L + T + P++ SL L + L E LK + +QL + L
Sbjct: 458 LAQRL------LEVTASLPDLP--SLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGI 509
Query: 5700 EDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHR 5759
+ L + L ++ +Q+ + +Q+ + Q++ + + LQ+ +
Sbjct: 510 FGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQV 569
Query: 5760 EIEDKPVATSNIQELQAQISRHEELAQK 5787
++ + ++ QAQ+SR + L ++
Sbjct: 570 RVQAEKGLQRDLPGKQAQLSRLQGLQEE 597
Score = 38.5 bits (88), Expect = 0.30
Identities = 94/549 (17%), Positives = 221/549 (40%), Gaps = 65/549 (11%)
Query: 4876 VTECESRM----VQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ 4931
+T C SR+ + ++ W +++ L + L L L++ Q ++ Q+
Sbjct: 101 MTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLL 160
Query: 4932 EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI 4991
V + +++ L + F + + S D + +E D A++ + ++
Sbjct: 161 HNVDNQAVLLDRLLEEAASLFNRIGDP-SVDEDAQKRMKAEYD-----AVKAKAQKRVDL 214
Query: 4992 YSQCQRYYQVFQAAND----WLEDAQELLQ--LAGN-GLDVESAEENLKSHMEFFSTEDQ 5044
Q R ++ +QA D WL+ E + L N L + L+ + F ++
Sbjct: 215 LEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEE 274
Query: 5045 FHSNLEELHS-LVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQW 5103
LEE + ++ PL +LE+ LE + + + + ++ L R W
Sbjct: 275 SLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLE-KLRALWEEEEERLRGLLRSRGAW 333
Query: 5104 HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSE---HKALVSVVNSFHEKIV 5160
K E + ++L++ L + + +E ++ + A + + S ++
Sbjct: 334 EQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVD 393
Query: 5161 ALEEKASQLE------KTGNDASKATLSRSMTTVWQRWTRLRAVA-----QDQEKILEDA 5209
L+ + +L K +D+ AT+ + ++ + RLR A Q ++ L+D
Sbjct: 394 RLQAQLKELIVFPHNLKPLSDSVIATI-QEYQSLKVKSARLRNAAAVELWQHFQRPLQD- 451
Query: 5210 VDEWTGFNNKVKKATEMIDQLQD------KLPGSSAEKASKAELLTLLEYHDTFVLELEQ 5263
+ W ++ + T + L ++ + E + ELLT+L+ ++ +
Sbjct: 452 LQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFG 511
Query: 5264 QQSALGMLRQQTLSM-----LQDGAAPTPGEEPPLMQE-------ITAMQDRCLNMQEKV 5311
Q+ A +L Q SM L + + L+ + +Q + L++Q +V
Sbjct: 512 QERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571
Query: 5312 KTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHR 5371
+ K ++++L ++ +++ ++ +++ AQ+E + L+ E NH+
Sbjct: 572 QAE-KGLQRDLPGKQAQLSRLQGLQ-----------EEGLDLGAQMEAARPLVQENPNHQ 619
Query: 5372 QNIEKMAEE 5380
+++++ +
Sbjct: 620 HKMDQLSSD 628
Score = 33.9 bits (76), Expect = 7.3
Identities = 123/705 (17%), Positives = 259/705 (36%), Gaps = 79/705 (11%)
Query: 578 EEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLN 637
++ ++ + + AQW + S +E V +W Y W + + M+
Sbjct: 78 DQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ--KMMVT 135
Query: 638 QSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDE---MVSRDLKQQLLLLN------- 687
+ + W H + L+ D ++ R L++ L N
Sbjct: 136 LEPHIELQLGLKEKQWQLSHAQV------LLHNVDNQAVLLDRLLEEAASLFNRIGDPSV 189
Query: 688 -----GRWRELFMEVKQYAQ--ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFM 740
R + + VK AQ D ++++ +E+ + + F + +
Sbjct: 190 DEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGR 249
Query: 741 NVKLLI----QDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQL 796
N KL I L+DI + P + + + + + + + + +++ + ++++ L
Sbjct: 250 NCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVL 309
Query: 797 TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 856
K++ + + LL E+Q+ L + ++ L +E A
Sbjct: 310 EKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTED 369
Query: 857 ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVA----FQSMV 912
EL+A T + V + L F + ++D +A +QS+
Sbjct: 370 ELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHN--LKPLSDSVIATIQEYQSLK 427
Query: 913 KKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD- 971
K+ + L + F+ +L+ +AQ LE +L HT F Q++
Sbjct: 428 VKSARLRNAAAV--ELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHT-FLPQIEA 484
Query: 972 --------QRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLK 1023
+ +L D L I ++ L E V + L L+
Sbjct: 485 ALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQ 544
Query: 1024 IDVEKNR-FLASVEEC-RTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLI 1081
+ +++ F A+ E R LD + ++ ++G ++ + + S RLQ +
Sbjct: 545 SLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLS----------RLQGL 594
Query: 1082 EELCVKL-----PVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD-------Y 1129
+E + L R V++ P H + +L + + R L + D+ + +
Sbjct: 595 QEEGLDLGAQMEAARPLVQENPNHQH-KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTF 653
Query: 1130 TSRFSEFSSWISTNETQLKGIKGEA---IDTANHGEVKRAVEEIRNGVTKRGETLSWLKS 1186
+ + E WI +L+ +GEA + E +R V E ++ LS +++
Sbjct: 654 SHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEF----PEKEAQLSLVEA 709
Query: 1187 RLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1231
+ ++ E SS A +EL +L+ S++AL L + ++ N+
Sbjct: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNW 754
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 273 bits (698), Expect = 5e-72
Identities = 597/2888 (20%), Positives = 1117/2888 (38%), Gaps = 509/2888 (17%)
Query: 12 RDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLS 71
R I N + L+DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLS
Sbjct: 5 RAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLS 62
Query: 72 GQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIIL 131
G LP E+GR R H + N+ AL +L R++KLVNI + DIADG P + LGL+WTIIL
Sbjct: 63 GDSLPREKGRM--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
Query: 132 YFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYT 191
+FQI ++ S S D AK+ LL W Q
Sbjct: 121 HFQISDI----------QVSGQSEDM---------------------TAKEKLLLWSQRM 149
Query: 192 AGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELG 251
G+ +F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG
Sbjct: 150 VEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLG 209
Query: 252 IPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQN 311
+ RLLDPEDVDV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 210 VTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLL 268
Query: 312 F------------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFR 355
+R F+E+++ QF E +L + ++ + YQS +
Sbjct: 269 LLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAV 328
Query: 356 VQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIG 415
++K H + GKL + L ++ R + ++ L G
Sbjct: 329 QAGQLKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCE 387
Query: 416 AWLYRAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTD 457
L +A+ L+ ++ + + + A ++R L++ ++ Q
Sbjct: 388 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 447
Query: 458 AHKRAF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLEL 508
++R + HE Y R G+ P Q+ V+ S ++E L
Sbjct: 448 MYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTL 500
Query: 509 KYRLLSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQY 556
+Y L LL E L S + G + Q ++ + + IE ++ E
Sbjct: 501 RY-LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG- 558
Query: 557 EVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML---- 608
Q+ T Y G ++ K +N + A+ R+L S + + ++
Sbjct: 559 ----QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNE 612
Query: 609 ---EEVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWI 654
EEV +W DR N A +++ LE EK + + +NA R P
Sbjct: 613 KEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVE 672
Query: 655 QQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT 714
A+ +++++ C + LK+ N + + F +V++ A+
Sbjct: 673 SFQAALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------- 715
Query: 715 DCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLIT 774
L +K S + ++ L+QD +D ++++ + K A +
Sbjct: 716 -----LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 770
Query: 775 KESPQEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTS 826
+ P+ M + +++ + K EC QL+ P + ++ S
Sbjct: 771 QLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLS 821
Query: 827 FYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLS 886
S + + ++ Q + ++ +T +E Q++ VTL
Sbjct: 822 SSGSEAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLW 861
Query: 887 NVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIA 946
+ L H D L +A+QS+ + + R +K EE R L +
Sbjct: 862 HQL-HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHY 911
Query: 947 QEGLEEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAV 1001
Q L + D PE+ L E+ S C L + +QG QE
Sbjct: 912 QAFLRDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEES 958
Query: 1002 R--KLHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-E 1052
R + + KD LQ EA H L L +D E R EC + + K + E
Sbjct: 959 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVE 1012
Query: 1053 GSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAI 1112
G K + RL E + LP P T LR+ +
Sbjct: 1013 GLGKGV-----------------ARLSAEAEKVLALPEPSPAAPT----------LRSEL 1045
Query: 1113 DSTYRKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGE 1162
+ T KL + Y + S + +E QLK +
Sbjct: 1046 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1105
Query: 1163 VKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSS 1213
K +++++R + T L+ L+ EV + E ++ + +A+L
Sbjct: 1106 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
Query: 1214 FKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTEN 1267
++A++ ++ L G ++Y + L + ++ QEQ A+ E
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
Query: 1268 LFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL--------------------- 1306
L + Q LL ++ +++ +R +Q I + E L
Sbjct: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1285
Query: 1307 -PDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHER 1365
+ +E L + L + + I TLR+ E E E Q ER
Sbjct: 1286 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER 1339
Query: 1366 FLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQA 1420
L + + LE+ ++ ++ QAE KE E+ + QQQ
Sbjct: 1340 ------LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1393
Query: 1421 KSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMD 1480
+SI+E++++L + E +I+ + E I +L A E +
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAE 1450
Query: 1481 MQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELR 1537
++ ++ +E E++ +EEA+ + V + +A++ ++++ E R
Sbjct: 1451 GELQALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507
Query: 1538 EHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
E + L+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1508 EKQRALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA--------- 1554
Query: 1598 LCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LE 1651
L S +F+ ++ S +E A+ Q E+ RRA+++ A E
Sbjct: 1555 ------ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606
Query: 1652 NLLAHWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQAL 1702
L WQ RL+ E + L + EA+ E + A R G+ +
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVR 1663
Query: 1703 QNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQS 1762
Q E+ Q + L + +A++ ++ ++ EQ +++ + L + + + +
Sbjct: 1664 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1723
Query: 1763 VVAEHQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE--- 1812
+ Q+ + L +++ L+ E ++TSE S + R ++ A E
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783
Query: 1813 ----VESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCF 1850
E K + Q + A KL ++G A ++ L + +AE+
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-- 1841
Query: 1851 QLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN 1910
E ++ E L E H + I +L Q +A++S + + L+E L
Sbjct: 1842 ---ERLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLR 1896
Query: 1911 DALQNAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGE 1958
Q + + + S + KA+ L++G S EQ A QL E
Sbjct: 1897 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956
Query: 1959 VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQR 2017
ER + ++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++
Sbjct: 1957 EERRRR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQ 2013
Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHEN 2077
L++ + K Q +K AFA V ++ L+ T + ++ +
Sbjct: 2014 LQLAQE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQL 2057
Query: 2078 QGQCCGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMN 2136
+G+ E + + A + ++ V + E+ A ++ + A K+
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 2137 YKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSL 2196
+ + ++ + K+ ++ K E T L ++E+ + LR+ L
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQL 2173
Query: 2197 SIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALR 2250
D + DE + A S ++ L + EEL K + E +N+AL
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233
Query: 2251 LEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2310
L + K N + L + E + A L + A + ++A+ +D Q E
Sbjct: 2234 LRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAE 2287
Query: 2311 KFINDITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNS 2365
K + + V+E+ A+ E + A ++ + +Q++ + ++ +
Sbjct: 2288 KMLKE---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2344
Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGA 2425
+LE A ++ E S+ QA +E ++ F + +E E
Sbjct: 2345 TLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRT 2398
Query: 2426 KAAAKESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSS 2484
+ A +E ++ + HD + + +++++ + + + + QE + L L + + +
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQT 2456
Query: 2485 IQEQITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENL 2543
+Q++ Q L++ QALQ SE S + R + ++E+ F E +
Sbjct: 2457 VQQE-------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-V 2502
Query: 2544 GESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLT 2603
+++Q E++ + ++E L+A+ E ++R Q +EEG QE
Sbjct: 2503 AKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE--------- 2549
Query: 2604 SHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKR 2663
L ++ +++ + ++ +E++ L E LQ + +A LA +E S+ K
Sbjct: 2550 ---ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKT 2603
Query: 2664 LSQIQDIL 2671
L +D L
Sbjct: 2604 LPNGRDAL 2611
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 227 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 286
Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 287 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 329
Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 330 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 378
Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 379 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 435
Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 436 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 492
Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 493 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 549
Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 550 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 601
Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 602 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 659
Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 660 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 717
Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 718 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 777
Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 778 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 832
Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
V + ++AQ + L L + +++ +++ L
Sbjct: 833 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 892
Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 893 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 952
Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 953 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1007
Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1008 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1065
Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1066 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1125
Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1126 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185
Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1186 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1245
Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1246 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1303
Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1304 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1359
Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
K + EV E D + +
Sbjct: 1360 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1397
Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
EE + +SE R + + ++I RLQ +A
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1442
Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1443 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1492
Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1493 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1547
Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607
Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
EL+ W L L L + +QK +A +E E E
Sbjct: 1608 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1648
Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1702
Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1703 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1759
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1760 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1812
Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1867
Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1868 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1909
Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1969
Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2028
Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2029 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2086 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2143
Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2203
Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263
Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2264 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2320
Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2375
Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2376 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2421
Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2422 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2462
Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2463 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2556
Score = 123 bits (309), Expect = 7e-27
Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)
Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 525 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 579
Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 580 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 635
Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
+ + EL + + +L G L E H A R T E
Sbjct: 636 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 674
Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 675 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 713
Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 714 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 753
Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 754 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 810
Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
++ + K S + A + A+E + ++E H + H+
Sbjct: 811 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 863
Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 864 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 923
Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 924 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 982
Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 983 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1041
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1042 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1089
Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1090 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1142
Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1143 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1202
Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1203 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1259
Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1260 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1319
Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
++ L R + E L V+ E Q ++ ++ Q + +QQ++Q
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1376
Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
+R + A + S Q+ ++Q S EA + RQ AE ++
Sbjct: 1377 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1423
Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
+ + + EE+ LE E + G + ELQ L+ R + + ++A
Sbjct: 1424 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1472
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
++E+L R Q+ + + EV L ++Q L L A E LR
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1532
Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
+ ++QV Q + L ++ Q E SL+++ A E
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1588
Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
+ R E+ ++++ W A E + R + + K + + +K EE
Sbjct: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648
Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
R + EE R +E+ ++ R + T Q R +A Q +Q +
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708
Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
LEEE+ L+ ++ +T K + + ++ KV M EVLL
Sbjct: 1709 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1750
Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
+ +S EK ++ + E EA R R E+ + +L+ L +++ E+ A
Sbjct: 1751 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1803
Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
++ ++ + L + +A E + E ++ L EK+A+ + + L++
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1863
Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
H+ ++ +R+ ++ LE LV+D ++++I L++ ++ + E
Sbjct: 1864 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1923
Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
L + ED ++ E + + + E + + LA K
Sbjct: 1924 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1983
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
A +EE+ + ++ + + + A LQ ++ LQ + +++ Q+
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2039
Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
Q L+ LQ+ S D L+ + +A A + E Q A++ +QV+ L
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2099
Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
+EQA+ + L + + A+ Q EQT+ QK
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2159
Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
Q LT EE H K+ L D++LQ +K +E A SQV++
Sbjct: 2160 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2206
Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
+ SV +E+++KL + E+ E++ + + R +N +E+ ++
Sbjct: 2207 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2250
Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
+ + + V ++ LA D A+ A+ + LK+ A+QE K E
Sbjct: 2251 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2309
Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
L+ QK+ E +DKE + +Q + E + FQ LE +R++++S +
Sbjct: 2310 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368
Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
E++ Q+R +E + +Q I E L ++ + L+ L I S+ +A++ L
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2426
Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
+ I + +R L E +++Q + Q+ L+ + + LSEK L
Sbjct: 2427 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2481
Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
Q I+Q + K+ L D+V+K + + Q + + E L A E
Sbjct: 2482 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534
Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
+ E E K E L +L++ + + +L + + RL+E + L+ +H
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2583
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1114 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1160
Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1161 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212
Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1213 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271
Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1272 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1327
Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
L E E+L+E +A + E + +A + K + + R
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1387
Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447
Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1503
Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1563
Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1564 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1683
Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1684 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1735
Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1793
Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1794 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853
Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913
Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973
Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 1974 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2022
Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2082
Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
+ + E L ++S EE + + A
Sbjct: 2083 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2117
Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
A +A+ QA ++ DA A Q + L
Sbjct: 2118 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175
Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2226
Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2227 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2285
Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2286 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2341
Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2342 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2384
Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2385 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2434
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2489 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2544
Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2601
Query: 6406 ALLP 6409
LP
Sbjct: 2602 KTLP 2605
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1122
Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1123 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1242
Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1243 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1302
Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1303 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1361
Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1362 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1418
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1419 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1466
Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1467 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1520
Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
++A+ A L EVE AE T L+ L
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1577
Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
H +V + E E E+ + R + S+ Q
Sbjct: 1578 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637
Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
A Q AER K +E E LE G Q+ + +I
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1697
Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1698 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1758 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1814
Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1869
Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929
Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
E +K++AE A + R+L K +L E+
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049
Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2050 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163
Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
L L EE Q + L+ + + S VEE LF
Sbjct: 2164 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2209
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
++ EE+ K K +NR +I L D
Sbjct: 2210 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2239
Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2240 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2299
Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2300 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465
Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2466 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2500
Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560
Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
Score = 104 bits (259), Expect = 4e-21
Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
L+TI+ + + E + E++L Q TL A K + Q T D
Sbjct: 1066 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1125
Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
+ AQ + + L E +++ R+ Q + W + + Q D+ L R
Sbjct: 1126 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185
Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
Q++++R + +L D + A + + Q + ++L Q Q L
Sbjct: 1186 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1233
Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
EEI+ ++ + A Q + +K EL+L + + V KK + + S
Sbjct: 1234 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1288
Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
+ I E V+ T + E+ L Q++ ++ ++ EE L Q+ + + +
Sbjct: 1289 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1341
Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
VE LEK LA + A++ A K+L +QE R+ A D + QK+ +
Sbjct: 1342 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397
Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
E L + E Q E+ ++E+ I+ ++Q+ T + EL ++
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457
Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
+R +E E + Q AE L++ D +Q + + S ++A KQ L++
Sbjct: 1458 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
L ++A+R + + + +Q AL AQ ++L +R + +EKT
Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1568
Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
L Q ++H RE ++ + + A+ L+ +Q NE L
Sbjct: 1569 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1674
Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
Q + + EL A+ + +Q E L LQR
Sbjct: 1675 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1723
Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
E L +L + + V++A K +E+ ++ +E
Sbjct: 1724 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1775
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
EL + R+ + + + L+ +D R + +++A +GEA + + +
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1835
Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
+K L + + QR L E + E+ QL + S E Q
Sbjct: 1836 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1887
Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
+ E+TL +++ + A + + L R+ + ED + E
Sbjct: 1888 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1947
Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
AR + + + E + E E R+ +S+ + E +R +L+ + R+KA++
Sbjct: 1948 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1998
Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
L + QE R++Q+ QE Q K L + + H+ A
Sbjct: 1999 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2035
Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
+ + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A + VE AE
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2093
Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
+S E Q + E+L +++ EQ+ A R ++
Sbjct: 2094 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2131
Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2180
Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
N E++ L+ +A++ + + + S + + R A+++ IL D
Sbjct: 2181 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2237
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
D F +++ E + Q+ ++ S A L L E +L QQ++
Sbjct: 2238 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2287
Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
+ ++ + +Q+ A E L Q+ Q++ +QE D+E +
Sbjct: 2288 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2332
Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
Q+ Q T E +E+ A+ E L++ + E A Q K AEE
Sbjct: 2333 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2392
Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
EK + +EL+ Q +V L + Q Q + E+ + EL R+ +KL ++
Sbjct: 2393 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2445
Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
L +LK++ VQ +++L E S L E D+ +Q +F+EQ +L +
Sbjct: 2446 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2500
Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2551
Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
QL +Q + LL EE++ + +L+ + E+ L + V ++ + + GR+
Sbjct: 2552 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2610
Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2611 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2651
Score = 100 bits (248), Expect = 8e-20
Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)
Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 370 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 426
Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 427 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 479
Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 480 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 536
Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 537 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 591
Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 592 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 649
Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 650 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 706
Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 707 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 766
Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
+++ +L R G G E +L SH +L + +
Sbjct: 767 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 826
Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 827 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 884
Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 885 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 940
Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 941 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 996
Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 997 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1050
Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1051 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1110
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
K++ ++++ L A EV + + H E W++
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1165
Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++ S
Sbjct: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1285
Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
G S +I+EY L S+ + Q + ++ ++ + + + +
Sbjct: 1286 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340
Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
+EV +L+K Q +L ++ + + KE + +Q +V +E +
Sbjct: 1341 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1389
Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
+ L+ L+ Q + E+ A+ Q ++ ++ E R+ L + E+Q+
Sbjct: 1390 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1448
Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
LQ++ E Q + +E+A++L + Q S+ R +L+S+ A + +E
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1508
Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
K L + Q + L+ + + + L++ EA L K
Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1559
Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
+ EK Q++ + + E QQQ ++ R + + E
Sbjct: 1560 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1607
Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
L +W + + + + + E+E+Q E + GKA+
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1658
Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
E V Q EL Q+L+++ + + A++ + ++L+RL E ++
Sbjct: 1659 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1702
Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
G++Q +L ++ + L+ +A ++L+ EL AE + LL S E
Sbjct: 1703 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
+ + + LE+ ++ + R + +L E+ +
Sbjct: 1755 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812
Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
+ E L E +T + KE + ++++ E+ R +EE A+ + ++E
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872
Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
R + R + L+ L Q + +EEEI +L+ S ++ G +
Sbjct: 1873 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1925
Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
+ + DT + K+ LE + + + RE ER K L E EA R RK
Sbjct: 1926 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1983
Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
+ +E+LK R+ E + L LA+E + K + E
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2028
Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
K + A K + LQQT+ + + +R + EA E ++ ++ + + QS
Sbjct: 2029 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085
Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
Q + S E + + + +++ K Q + R + +
Sbjct: 2086 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2143
Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
++ HK E+ A E L L+++ + DH + L + LQ K
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2191
Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
A + A R +E EL + + L + +A + A + D + + + AE
Sbjct: 2192 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2250
Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
+KQV +E AR S+ A ++ A++ ++ + +K+++ + Q
Sbjct: 2251 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2297
Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
+E LK+E + LQ + Q RR E + +AQ + + + F + L++++
Sbjct: 2298 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356
Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
A + +V ++++ + E K+ + ++ +L Q +Q E +Q
Sbjct: 2357 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2415
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
R + HD + E +A + E + EA K L L +E + ++
Sbjct: 2416 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2463
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
Q+ + ++ L +K+ + ++ +EQ +LE L Q V ++L Q R Q+ M
Sbjct: 2464 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2519
Query: 4358 EWAEEQQPNIA 4368
E +E+Q +A
Sbjct: 2520 E--QERQRLVA 2528
Score = 98.6 bits (244), Expect = 2e-19
Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)
Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
H++ L K+ A E + E Q Q + LG + + L +AE L E S
Sbjct: 983 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1036
Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
+ L L+ SLS I + +T+ + +++ + L+ A+A
Sbjct: 1037 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1095
Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
+ + L+ + + L+ + Q+ + A D+L G EV ER+Q G + E +
Sbjct: 1096 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1154
Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
++++ +LL+ + + +TD +++ + L ++LR + + D L +
Sbjct: 1155 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1199
Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
WL+D ++ Q+ + P D + R ++ + L+ E +
Sbjct: 1200 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1240
Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
V + A I IKD E L + ++ + + S
Sbjct: 1241 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1277
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
KK V++ ES + +++D+ E + + L +E E +
Sbjct: 1278 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1331
Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
+ E ++ ++ L + L E ++ K +A R +EL ++ + E+ + E D
Sbjct: 1332 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1389
Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
Q + + ++L+ ++ +E + A++ Q E A+
Sbjct: 1390 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1424
Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
++++ ++ +L++ + + L +L + AE E L R +
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
+K +A +L S+ +A + + EK ++Q +E L A+ A + ++ +A
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1533
Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
++ + + ++ Q +A Q + +A + Q+ S+QE+ + + EE + +
Sbjct: 1534 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
Q + ++A ++ EL ++ ++ +L L E+ ++ + KQ E + E
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1652
Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
+ + + RE ++ ++ + L+E G Q Q L + Q L+R+ E
Sbjct: 1653 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1700
Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
+ Q+ + LEE L + R A A + + LE L+++ + E E
Sbjct: 1701 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1743
Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
V L + + E+ RS++++ ++ ++ + +E+ + A+ D
Sbjct: 1744 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1802
Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
++ + E + + ++ + + + LKEK + L+ + + R L
Sbjct: 1803 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862
Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
A+ + E+ + + + EL+ Q + +++ + EEI+ + A +
Sbjct: 1863 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1921
Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
+ S E+ R + + +A Q++L+ +E R R+ + + E
Sbjct: 1922 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 1979
Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
+ A+ E+ + +A R + ++S Q Q E ++ E+ + V Q
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
EQ L+Q T Q+ ++L+ + E +E +A +AE + Q+ E
Sbjct: 2040 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2091
Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
R + + + L +A + + Q Q R Q+ +A++
Sbjct: 2092 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2145
Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
K F Q + + + Q++ + E H+ N++ E+ + ++A
Sbjct: 2146 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2192
Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
+ T A Q E L ++++QM++ LSK + + E+ NR
Sbjct: 2193 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2233
Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
L K Q+ LQ E++ + RL AQ+ R+ QL+ + LA
Sbjct: 2234 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2282
Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
EK+ +KE ++V ++ LK EA
Sbjct: 2283 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2307
Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
L ++Q+KE+ Q + + E + Q + E Q+ L++ + + + R K
Sbjct: 2308 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2365
Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
+ V + S E + +Q E+ +K L + +L +E ++
Sbjct: 2366 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2407
Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
L++T+E++ ++H +L + +L+ +Q+ AK KSE++ + QE
Sbjct: 2408 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2461
Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
L QE + L Q + E D+ + ++ ++ Q + V ++
Sbjct: 2462 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2507
Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
+ + + R + + Q+ Q + E R + + +R +++ QQ+++ + EE
Sbjct: 2508 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2564
Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
++ + N+ +E QL +++ H A+ +EV
Sbjct: 2565 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2593
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1151 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1210
Query: 639 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1211 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1270
Query: 690 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1271 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1330
Query: 747 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1387
Query: 805 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
+ + + L++L +Q + S +I E I V+
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447
Query: 843 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507
Query: 884 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566
Query: 936 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626
Query: 993 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1680
Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1681 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1729
Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1780
Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
+RL+ L E + + D + + + + L L+ +
Sbjct: 1781 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1820
Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1821 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1867
Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1868 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1921 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1971
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1972 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2025
Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2026 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2082
Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2083 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142
Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202
Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2203 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2259
Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2260 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2319
Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2320 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2378
Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2379 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2429
Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2484
Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2485 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2539
Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2540 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2590
Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2591 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2642
Query: 2086 DLMREYQNLKSAVSKVLENA 2105
E Q L + V E A
Sbjct: 2643 S-AEELQRLAQGHTTVDELA 2661
Score = 84.0 bits (206), Expect = 6e-15
Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)
Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
G+ E++R ++E+LK ++ +R E+ L +E + +A+ + E
Sbjct: 1050 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1103
Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
E K L + +AQ ++ Q T + ++ +E GE L + V+ +++
Sbjct: 1104 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1158
Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
+ QL +Q + + LE + Y + WL R + +
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1218
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
+ + +QL +A++EEI +++ Q I D+ +A+L+
Sbjct: 1219 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1278
Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
++V + YS + + + + + L++ + +Q +A
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1338
Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
L+ V+ LE Q ++A+A ++ K + ++ + S++
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1398
Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
+ ++Q +E I+ K QA+ + EEI+ ++ +L + A+ +LQ ++
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1458
Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
R E E A+ + QV+D + + +QA V E +++ + E+ K+
Sbjct: 1459 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1512
Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ L + L L R+ +++R R + + E E + S AE
Sbjct: 1513 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1566
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
TA +L +LQE A+ L+++ ++ + + E +E+ +RW +
Sbjct: 1567 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1617
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ ++ ++Q ++ ++ Q+ ++ E AE + +A +Q+ ++
Sbjct: 1618 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+E A+Q L R + G +RQ++++ L+ Q + + L
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
K +E L + +A + + K FRE L ++ ++ + A+
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1792
Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
+ + + A+ ++ EK +G+ L++ + L++ + RL+ L
Sbjct: 1793 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1847
Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
E R+ +E A H +ADI SEL Q ++ L Q + E
Sbjct: 1848 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1902
Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
+L L+ + + E++ + NA E L KE
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1942
Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
A L + L+ E + R + +V LA EE + Q +A L+EV L V+E
Sbjct: 1943 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2000
Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
+ +E + + L L + + Q E++ ++ Q+ + +
Sbjct: 2001 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2055
Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
QL + ++ + + E + AE + + A L+ S + + A
Sbjct: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115
Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
L A ++A + Q+ Q L+ +A E ++++ Q + +
Sbjct: 2116 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175
Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
T+ ++L + L+R+KAE + ++EE+ +++ EE+ RI AL
Sbjct: 2176 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232
Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
++K+ + + + ++ E + L QEA R RQ ++ Q +
Sbjct: 2233 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2292
Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
Q Q A + L+ +EL Q L D E + L + F
Sbjct: 2293 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2352
Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
+ + + E L VA + + +ED ++ E +++ R A +V L+Q
Sbjct: 2353 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411
Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
Q HD ++ RE + EL + EK E LL+ S + E+ L E +AL
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471
Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
+S +S ++ +E++ ++LE+ D +KA R ++ + + + Q+++++
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2526
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
+ + + +A E + + Q++L ++ + ELL L+L ++Q
Sbjct: 2527 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
+ + ++ Q A T
Sbjct: 2583 HRAALAHSEEVTASQVAATKT 2603
Score = 72.8 bits (177), Expect = 1e-11
Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)
Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
Q+ + T L AQ A++ H+ V+++ +L W Q L R ++++ S S+ +
Sbjct: 841 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 892
Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
++ E R Q L S YQ L D G D + G C
Sbjct: 893 RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 939
Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
++ + L LE + +R Q SE D+ L++ + R T + +P +
Sbjct: 940 ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 991
Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
E R+ E K EV+ + + + ++L L + A TLRSEL
Sbjct: 992 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1048
Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
L + V+ L + ++KL + IS V+ E V++ E+ +K + A
Sbjct: 1049 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1100
Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
L+ K + +Q T D + + + +DVE +R +
Sbjct: 1101 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1155
Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
E++ + + WQ + + + LE L Y + L W + +R +Q +
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1214
Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
L D Q + + ++ ++ +E+IE++G
Sbjct: 1215 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1240
Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
V + + K ++ +++ + L + ++ +GS +Q VD
Sbjct: 1241 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1296
Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
L+ +L ++T+Q +K ++ETL +E + EE E+L
Sbjct: 1297 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1341
Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
+A L+ + + ++ A Q E EL + + + +E A D +
Sbjct: 1342 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1392
Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
++++ L L + E + Q A A A + +L + + + + L + T Q G
Sbjct: 1393 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1449
Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
+ E L+AL A EAE + QE E L+ Q+ S +
Sbjct: 1450 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
EL R+ + + Q + + Q E +L+ ++ Q LE +
Sbjct: 1494 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1551
Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
E +Q+++ E + + L+++ A +AE ++QQ + +R LE+
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
Q+ + L+L ++ Q A++++ + + R+ + E A + R E+
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1667
Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
+ + + Q R ++ E + LR + E G+Q
Sbjct: 1668 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1709
Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
L+ ELA +Q + +A+ + +E + +LA + + E A + E+ R+ +K Q L
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
EL E R + L + + + + + A+ ++ + E L +
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1828
Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
+ E + +++ RL E F + E E DI EE + +L+
Sbjct: 1829 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1877
Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
K E+ + ++ Q +Q+ E + KAS E A+ E+E +LG++ + L
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937
Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
+L AAR ++L + A +++ K++++ E E A+
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 1989
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
E ++ K+ E + L+ E+ S A L L + A ++QQ + L +
Sbjct: 1990 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
+ ++ + R + E R ++ E+ +ER AA E L
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2095
Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
K+ Q Q + E + K+ + A +L+Q ++ +
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2143
Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
+ + K F Q R++ + ++ LT + LQL +H + ++++LKA E
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2197
Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
+ +++E+ + Q E+L + ++A A+I + D +R+ QE ++++ ++
Sbjct: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257
Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
RL + E L++ +L + + A L ++ + + L L + L
Sbjct: 2258 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2316
Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
E++ R + R LE+ R L E + + LR A +S
Sbjct: 2317 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2371
Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
+ E ++ K ++ ++ +TE + K L+ + +I
Sbjct: 2372 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2431
Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
++R + KL++E + L L S E QT +Q + L +E + Q Q F
Sbjct: 2432 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2473
Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
S+ +S+ E+E +L++L + +L+ ++ ++ Q+ R+ ++ S+
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533
Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
+A+ R Q+ L Q+ + + LL E L++ L + H
Sbjct: 2534 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583
Score = 66.6 bits (161), Expect = 1e-09
Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)
Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1120 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1172
Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1173 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1232
Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1233 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1292
Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1293 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1339
Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1340 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1394
Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454
Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1575 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628
Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1629 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1682
Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1683 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
E + EM++ L + E K + + E ++ + A+ L
Sbjct: 1732 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1787
Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
E+++ + EE+ R + V + RL + E L ++E E E
Sbjct: 1788 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1845
Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
L++ R + Q +++ LAQ ++ S + + L +
Sbjct: 1846 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1905
Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
L E A + E E G + + + LR S + + LE+ RQ A ++ R
Sbjct: 1906 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1959
Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
+ ++ E ++ E K ++ + + ++ +RL + ++E
Sbjct: 1960 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2013
Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
L + + E A A+ KE ++Q LQ+ Q L EE E+
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
R++ + Q+++ + L+++ + + + + +A+ + +R Q
Sbjct: 2074 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2132
Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
+ + + + +E+ + + L Q + L L LE D +KN + L
Sbjct: 2133 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2191
Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
AE + +Q Q++ EL ++++ L + ++
Sbjct: 2192 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2225
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 957 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1004
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1005 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1062
Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1121
Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1122 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1163
Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1164 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1219
Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1220 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1272
Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1273 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1332
Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1333 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1392
Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1393 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1452
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1511
Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1512 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1566
Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1567 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1624
Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1625 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1685 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1743
Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1744 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1795
Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1796 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1845
Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1846 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1890
Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1891 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1923
Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1924 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1983
Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2041
Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2042 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2084
Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2139
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2140 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2192
Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2252
Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2253 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2304
Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2305 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2345
Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2346 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2399
Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2400 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2441
Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2442 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2483
Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2484 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2534
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
R QH + V++ +E L QQL++ LA +
Sbjct: 2535 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2569
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2570 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2623
Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2624 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2680
Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
E+L + A QRQ+ T L L+ Q
Sbjct: 2681 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2711
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 270 bits (691), Expect = 4e-71
Identities = 599/2898 (20%), Positives = 1121/2898 (38%), Gaps = 511/2898 (17%)
Query: 2 ATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGV 61
A S G+ P + A + R+ DE++ VQK+TFTKW+N HL K + + DL+ED++DG
Sbjct: 46 AGSNGSVLDPAERAVI--RIADERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGH 101
Query: 62 KLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSI 121
L++LLEVLSG LP E+GR R H + N+ AL +L R++KLVNI + DIADG P +
Sbjct: 102 NLISLLEVLSGDSLPREKGRM--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKL 159
Query: 122 VLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAK 181
LGL+WTIIL+FQI ++ S S D AK
Sbjct: 160 TLGLIWTIILHFQISDI----------QVSGQSEDM---------------------TAK 188
Query: 182 KALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLED 241
+ LL W Q G+ +F SWR G F+++IH +P L+D+ V ++N ENL+
Sbjct: 189 EKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 248
Query: 242 AFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPG 301
AF++AE +LG+ RLLDPEDVDV +PDEKSI+TYV+ P + + DG +E+
Sbjct: 249 AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLR 307
Query: 302 FPSFANSVQNF------------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQ 345
+ + V +R F+E+++ QF E +L + ++ +
Sbjct: 308 WQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSK 367
Query: 346 DKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDK 405
YQS + ++K H + GKL + L ++ R + ++
Sbjct: 368 GIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVT 426
Query: 406 SLPAPLGTIGAWLYRAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL---------- 453
L G L +A+ L+ ++ + + + A ++R L++ ++
Sbjct: 427 KLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL 486
Query: 454 ------QNTDAHKRAF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSEL 498
Q ++R + HE Y R G+ P Q+ V+ S
Sbjct: 487 KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQ 539
Query: 499 HLMKMEFLELKYRLLSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSF 546
++E L+Y L LL E L S + G + Q ++ + +
Sbjct: 540 RRPELEDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 598
Query: 547 IENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVR 602
IE ++ E Q+ T Y G ++ K +N + A+ R+L S
Sbjct: 599 IERARSDEG-----QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAA 651
Query: 603 SVRSML-------EEVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFR 648
+ + ++ EEV +W DR N A +++ LE EK + + +NA R
Sbjct: 652 ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLR 711
Query: 649 N----LPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQAD 704
P A+ +++++ C + LK+ N + + F +V++ A+
Sbjct: 712 EDHPARPTVESFQAALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ 764
Query: 705 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYK 764
L +K S + ++ L+QD +D ++++
Sbjct: 765 ---------------LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 809
Query: 765 IITKTAHLITKESPQEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIP 816
+ K A + + P+ M + +++ + K EC QL+ P
Sbjct: 810 GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGP 860
Query: 817 LEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGS 876
+ ++ S S + + ++ Q + ++ +T +E
Sbjct: 861 AQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQH 903
Query: 877 QSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESR 936
Q++ VTL + L H D L +A+QS+ + + R +K EE R
Sbjct: 904 QAL---VTLWHQL-HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQR 950
Query: 937 AELEKVLRIAQEGLEEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPE 991
L + Q L + D PE+ L E+ S C L +
Sbjct: 951 QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQ 997
Query: 992 QEQQGLQEAVR--KLHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELD 1043
+QG QE R + + KD LQ EA H L L +D E R EC +
Sbjct: 998 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIA 1051
Query: 1044 RETKLMPQ-EGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCH 1102
+ K + EG K + RL E + LP P T
Sbjct: 1052 EQQKAQAEVEGLGKGV-----------------ARLSAEAEKVLALPEPSPAAPT----- 1089
Query: 1103 VTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKG 1152
LR+ ++ T KL + Y + S + +E QLK +
Sbjct: 1090 -----LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
Query: 1153 EAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQ 1203
K +++++R + T L+ L+ EV + E ++
Sbjct: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
Query: 1204 GDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ----- 1258
+ +A+L ++A++ ++ L G ++Y + L + ++ QEQ
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
Query: 1259 -AEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL----------- 1306
A+ E L + Q LL ++ +++ +R +Q I + E L
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
Query: 1307 -----------PDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
+ +E L + L + + I TLR+ E E E
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ---- 1380
Query: 1356 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGP 1410
Q ER L + + LE+ ++ ++ QAE KE E+
Sbjct: 1381 --QRAEERER------LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432
Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
+ QQQ +SI+E++++L + E +I+ + E I +L
Sbjct: 1433 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLE 1489
Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---T 1527
A E + ++ ++ +E E++ +EEA+ + V + +A++ +
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELAS 1546
Query: 1528 QIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1587
+++ E RE + L+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1547 RVKAEAEAAREKQRALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAE 1602
Query: 1588 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1647
L S +F+ ++ S +E A+ Q E+ RRA+++
Sbjct: 1603 A---------------ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQA 1645
Query: 1648 TA------LENLLAHWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKV 1692
A E L WQ RL+ E + L + EA+ E + A R
Sbjct: 1646 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR--- 1702
Query: 1693 EGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQI 1752
G+ + Q E+ Q + L + +A++ ++ ++ EQ +++ + L +
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762
Query: 1753 INKRINFLQSVVAEHQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTR 1805
+ + + + Q+ + L +++ L+ E ++TSE S + R
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1822
Query: 1806 HKDHAAE-------VESKKGELQSLQGHLA------------KLGSLGRA------EDLH 1840
++ A E E K + Q + A KL ++G A ++
Sbjct: 1823 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882
Query: 1841 LLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKN 1900
L + +AE+ E ++ E L E H + I +L Q +A++S +
Sbjct: 1883 LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELER 1935
Query: 1901 ESDLIEKDLNDALQNAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSC 1948
+ L+E L Q + + + S + KA+ L++G S EQ
Sbjct: 1936 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1995
Query: 1949 RATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLK 2007
A QL E ER + ++ +LA ++A + Q++ L+ +E ++ + ++ RL+
Sbjct: 1996 AARQRQLAAEEERRRR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLR 2052
Query: 2008 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTW 2067
E Q ++L++ + K Q +K AFA V ++ L+ T
Sbjct: 2053 ERAEQESARQLQLAQE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTL 2096
Query: 2068 DDTKRLIHENQGQCCGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFS 2126
+ ++ + +G+ E + + A + ++ V + E+ A +
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2156
Query: 2127 KHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLE 2186
+ + A K+ + + ++ + K+ ++ K E T L ++E
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVE 2212
Query: 2187 ENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EF 2240
+ + LR+ L D + DE + A S ++ L + EEL K +
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272
Query: 2241 ESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLK 2300
E +N+AL L + K N + L + E + A L + A + ++A+ +
Sbjct: 2273 RIEAENRALILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---E 2326
Query: 2301 DFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSN 2355
D Q EK + + V+E+ A+ E + A ++ + +Q++ +
Sbjct: 2327 DLAQQRALAEKMLKE---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2383
Query: 2356 ISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESM 2415
++ + +LE A ++ E S+ QA +E ++ F +
Sbjct: 2384 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQA 2437
Query: 2416 QEFQEWFLGAKAAAKESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLY 2474
+E E + A +E ++ + HD + + +++++ + + + + QE + L
Sbjct: 2438 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL- 2496
Query: 2475 AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHE 2533
L + + ++Q++ Q L++ QALQ SE S + R + +
Sbjct: 2497 -QLKSEEMQTVQQE-------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2542
Query: 2534 MEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQ 2593
+E+ F E + +++Q E++ + ++E L+A+ E ++R Q +EEG Q
Sbjct: 2543 LEQLFQDE-VAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQ 2597
Query: 2594 EGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST 2653
E L ++ +++ + ++ +E++ L E LQ + +A LA +E
Sbjct: 2598 E------------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEV 2642
Query: 2654 LGSKDTLEKRLSQIQDIL 2671
S+ K L +D L
Sbjct: 2643 TASQVAATKTLPNGRDAL 2660
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 276 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 335
Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 336 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 378
Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 379 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 427
Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 428 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 484
Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 485 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 541
Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 542 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 598
Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 599 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 650
Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 651 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 708
Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 709 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 766
Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 767 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 826
Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 827 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 881
Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
V + ++AQ + L L + +++ +++ L
Sbjct: 882 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 941
Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 942 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1001
Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 1002 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1056
Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1057 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1114
Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1115 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1174
Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1175 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234
Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1235 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1294
Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1295 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1352
Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1353 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1408
Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
K + EV E D + +
Sbjct: 1409 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1446
Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
EE + +SE R + + ++I RLQ +A
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1491
Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1492 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1541
Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1542 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1596
Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
EL+ W L L L + +QK +A +E E E
Sbjct: 1657 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1697
Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1751
Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1752 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1808
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1809 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1861
Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1916
Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1917 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1958
Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2018
Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 2019 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2077
Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2078 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2135 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2192
Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2193 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2252
Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312
Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2313 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2369
Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2424
Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2425 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2470
Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2471 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2511
Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2512 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2605
Score = 123 bits (309), Expect = 7e-27
Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)
Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 574 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 628
Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 629 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 684
Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
+ + EL + + +L G L E H A R T E
Sbjct: 685 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 723
Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 724 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 762
Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 763 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 802
Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 803 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 859
Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
++ + K S + A + A+E + ++E H + H+
Sbjct: 860 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 912
Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 913 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 972
Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 973 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1031
Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 1032 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1090
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1091 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1138
Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1139 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1191
Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1192 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1251
Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1252 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1308
Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1309 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1368
Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
++ L R + E L V+ E Q ++ ++ Q + +QQ++Q
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1425
Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
+R + A + S Q+ ++Q S EA + RQ AE ++
Sbjct: 1426 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1472
Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
+ + + EE+ LE E + G + ELQ L+ R + + ++A
Sbjct: 1473 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1521
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
++E+L R Q+ + + EV L ++Q L L A E LR
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1581
Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
+ ++QV Q + L ++ Q E SL+++ A E
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1637
Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
+ R E+ ++++ W A E + R + + K + + +K EE
Sbjct: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697
Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
R + EE R +E+ ++ R + T Q R +A Q +Q +
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757
Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
LEEE+ L+ ++ +T K + + ++ KV M EVLL
Sbjct: 1758 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1799
Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
+ +S EK ++ + E EA R R E+ + +L+ L +++ E+ A
Sbjct: 1800 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1852
Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
++ ++ + L + +A E + E ++ L EK+A+ + + L++
Sbjct: 1853 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1912
Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
H+ ++ +R+ ++ LE LV+D ++++I L++ ++ + E
Sbjct: 1913 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1972
Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
L + ED ++ E + + + E + + LA K
Sbjct: 1973 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2032
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
A +EE+ + ++ + + + A LQ ++ LQ + +++ Q+
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2088
Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
Q L+ LQ+ S D L+ + +A A + E Q A++ +QV+ L
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2148
Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
+EQA+ + L + + A+ Q EQT+ QK
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2208
Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
Q LT EE H K+ L D++LQ +K +E A SQV++
Sbjct: 2209 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2255
Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
+ SV +E+++KL + E+ E++ + + R +N +E+ ++
Sbjct: 2256 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2299
Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
+ + + V ++ LA D A+ A+ + LK+ A+QE K E
Sbjct: 2300 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2358
Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
L+ QK+ E +DKE + +Q + E + FQ LE +R++++S +
Sbjct: 2359 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
E++ Q+R +E + +Q I E L ++ + L+ L I S+ +A++ L
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2475
Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
+ I + +R L E +++Q + Q+ L+ + + LSEK L
Sbjct: 2476 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2530
Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
Q I+Q + K+ L D+V+K + + Q + + E L A E
Sbjct: 2531 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583
Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
+ E E K E L +L++ + + +L + + RL+E + L+ +H
Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2632
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1163 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1209
Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1210 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261
Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1262 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1321 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1376
Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
L E E+L+E +A + E + +A + K + + R
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1436
Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496
Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1552
Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1612
Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1613 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1732
Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1733 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1784
Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1785 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1842
Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1843 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1902
Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962
Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2022
Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 2023 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2071
Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2131
Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
+ + E L ++S EE + + A
Sbjct: 2132 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2166
Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
A +A+ QA ++ DA A Q + L
Sbjct: 2167 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224
Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2225 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2275
Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2276 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2334
Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2335 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2390
Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2391 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2433
Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2434 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2483
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2538 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2593
Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2650
Query: 6406 ALLP 6409
LP
Sbjct: 2651 KTLP 2654
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1171
Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1172 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1291
Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1292 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1351
Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1352 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1410
Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1411 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1467
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1468 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1515
Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1516 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1569
Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
++A+ A L EVE AE T L+ L
Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1626
Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
H +V + E E E+ + R + S+ Q
Sbjct: 1627 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686
Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
A Q AER K +E E LE G Q+ + +I
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1746
Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1747 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1807 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1863
Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1864 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1918
Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978
Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
E +K++AE A + R+L K +L E+
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098
Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2099 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
L L EE Q + L+ + + S VEE LF
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2258
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
++ EE+ K K +NR +I L D
Sbjct: 2259 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2288
Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2289 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2348
Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2349 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514
Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2515 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2549
Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609
Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
Score = 104 bits (259), Expect = 4e-21
Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
L+TI+ + + E + E++L Q TL A K + Q T D
Sbjct: 1115 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1174
Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
+ AQ + + L E +++ R+ Q + W + + Q D+ L R
Sbjct: 1175 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234
Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
Q++++R + +L D + A + + Q + ++L Q Q L
Sbjct: 1235 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1282
Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
EEI+ ++ + A Q + +K EL+L + + V KK + + S
Sbjct: 1283 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1337
Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
+ I E V+ T + E+ L Q++ ++ ++ EE L Q+ + + +
Sbjct: 1338 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1390
Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
VE LEK LA + A++ A K+L +QE R+ A D + QK+ +
Sbjct: 1391 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446
Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
E L + E Q E+ ++E+ I+ ++Q+ T + EL ++
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506
Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
+R +E E + Q AE L++ D +Q + + S ++A KQ L++
Sbjct: 1507 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
L ++A+R + + + +Q AL AQ ++L +R + +EKT
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1617
Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
L Q ++H RE ++ + + A+ L+ +Q NE L
Sbjct: 1618 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1723
Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
Q + + EL A+ + +Q E L LQR
Sbjct: 1724 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1772
Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
E L +L + + V++A K +E+ ++ +E
Sbjct: 1773 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1824
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
EL + R+ + + + L+ +D R + +++A +GEA + + +
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1884
Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
+K L + + QR L E + E+ QL + S E Q
Sbjct: 1885 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1936
Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
+ E+TL +++ + A + + L R+ + ED + E
Sbjct: 1937 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1996
Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
AR + + + E + E E R+ +S+ + E +R +L+ + R+KA++
Sbjct: 1997 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2047
Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
L + QE R++Q+ QE Q K L + + H+ A
Sbjct: 2048 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2084
Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
+ + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A + VE AE
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2142
Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
+S E Q + E+L +++ EQ+ A R ++
Sbjct: 2143 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2180
Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2229
Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
N E++ L+ +A++ + + + S + + R A+++ IL D
Sbjct: 2230 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2286
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
D F +++ E + Q+ ++ S A L L E +L QQ++
Sbjct: 2287 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2336
Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
+ ++ + +Q+ A E L Q+ Q++ +QE D+E +
Sbjct: 2337 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2381
Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
Q+ Q T E +E+ A+ E L++ + E A Q K AEE
Sbjct: 2382 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2441
Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
EK + +EL+ Q +V L + Q Q + E+ + EL R+ +KL ++
Sbjct: 2442 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2494
Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
L +LK++ VQ +++L E S L E D+ +Q +F+EQ +L +
Sbjct: 2495 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2549
Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2600
Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
QL +Q + LL EE++ + +L+ + E+ L + V ++ + + GR+
Sbjct: 2601 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2659
Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2660 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2700
Score = 100 bits (248), Expect = 8e-20
Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)
Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 419 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 475
Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 476 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 528
Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 529 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 585
Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 586 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 640
Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 641 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 698
Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 699 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 755
Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 756 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 815
Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
+++ +L R G G E +L SH +L + +
Sbjct: 816 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 875
Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 876 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 933
Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 934 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 989
Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 990 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1045
Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1099
Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1100 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1159
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
K++ ++++ L A EV + + H E W++
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1214
Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++ S
Sbjct: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1334
Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
G S +I+EY L S+ + Q + ++ ++ + + + +
Sbjct: 1335 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389
Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
+EV +L+K Q +L ++ + + KE + +Q +V +E +
Sbjct: 1390 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1438
Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
+ L+ L+ Q + E+ A+ Q ++ ++ E R+ L + E+Q+
Sbjct: 1439 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1497
Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
LQ++ E Q + +E+A++L + Q S+ R +L+S+ A + +E
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1557
Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
K L + Q + L+ + + + L++ EA L K
Sbjct: 1558 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1608
Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
+ EK Q++ + + E QQQ ++ R + + E
Sbjct: 1609 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1656
Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
L +W + + + + + E+E+Q E + GKA+
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1707
Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
E V Q EL Q+L+++ + + A++ + ++L+RL E ++
Sbjct: 1708 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1751
Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
G++Q +L ++ + L+ +A ++L+ EL AE + LL S E
Sbjct: 1752 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803
Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
+ + + LE+ ++ + R + +L E+ +
Sbjct: 1804 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861
Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
+ E L E +T + KE + ++++ E+ R +EE A+ + ++E
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921
Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
R + R + L+ L Q + +EEEI +L+ S ++ G +
Sbjct: 1922 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1974
Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
+ + DT + K+ LE + + + RE ER K L E EA R RK
Sbjct: 1975 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2032
Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
+ +E+LK R+ E + L LA+E + K + E
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2077
Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
K + A K + LQQT+ + + +R + EA E ++ ++ + + QS
Sbjct: 2078 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134
Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
Q + S E + + + +++ K Q + R + +
Sbjct: 2135 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2192
Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
++ HK E+ A E L L+++ + DH + L + LQ K
Sbjct: 2193 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2240
Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
A + A R +E EL + + L + +A + A + D + + + AE
Sbjct: 2241 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2299
Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
+KQV +E AR S+ A ++ A++ ++ + +K+++ + Q
Sbjct: 2300 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2346
Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
+E LK+E + LQ + Q RR E + +AQ + + + F + L++++
Sbjct: 2347 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405
Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
A + +V ++++ + E K+ + ++ +L Q +Q E +Q
Sbjct: 2406 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2464
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
R + HD + E +A + E + EA K L L +E + ++
Sbjct: 2465 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2512
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
Q+ + ++ L +K+ + ++ +EQ +LE L Q V ++L Q R Q+ M
Sbjct: 2513 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2568
Query: 4358 EWAEEQQPNIA 4368
E +E+Q +A
Sbjct: 2569 E--QERQRLVA 2577
Score = 98.6 bits (244), Expect = 2e-19
Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)
Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
H++ L K+ A E + E Q Q + LG + + L +AE L E S
Sbjct: 1032 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1085
Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
+ L L+ SLS I + +T+ + +++ + L+ A+A
Sbjct: 1086 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1144
Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
+ + L+ + + L+ + Q+ + A D+L G EV ER+Q G + E +
Sbjct: 1145 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1203
Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
++++ +LL+ + + +TD +++ + L ++LR + + D L +
Sbjct: 1204 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1248
Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
WL+D ++ Q+ + P D + R ++ + L+ E +
Sbjct: 1249 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1289
Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
V + A I IKD E L + ++ + + S
Sbjct: 1290 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1326
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
KK V++ ES + +++D+ E + + L +E E +
Sbjct: 1327 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1380
Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
+ E ++ ++ L + L E ++ K +A R +EL ++ + E+ + E D
Sbjct: 1381 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1438
Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
Q + + ++L+ ++ +E + A++ Q E A+
Sbjct: 1439 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1473
Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
++++ ++ +L++ + + L +L + AE E L R +
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
+K +A +L S+ +A + + EK ++Q +E L A+ A + ++ +A
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1582
Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
++ + + ++ Q +A Q + +A + Q+ S+QE+ + + EE + +
Sbjct: 1583 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
Q + ++A ++ EL ++ ++ +L L E+ ++ + KQ E + E
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1701
Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
+ + + RE ++ ++ + L+E G Q Q L + Q L+R+ E
Sbjct: 1702 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1749
Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
+ Q+ + LEE L + R A A + + LE L+++ + E E
Sbjct: 1750 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1792
Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
V L + + E+ RS++++ ++ ++ + +E+ + A+ D
Sbjct: 1793 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1851
Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
++ + E + + ++ + + + LKEK + L+ + + R L
Sbjct: 1852 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911
Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
A+ + E+ + + + EL+ Q + +++ + EEI+ + A +
Sbjct: 1912 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1970
Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
+ S E+ R + + +A Q++L+ +E R R+ + + E
Sbjct: 1971 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 2028
Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
+ A+ E+ + +A R + ++S Q Q E ++ E+ + V Q
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
EQ L+Q T Q+ ++L+ + E +E +A +AE + Q+ E
Sbjct: 2089 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2140
Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
R + + + L +A + + Q Q R Q+ +A++
Sbjct: 2141 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2194
Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
K F Q + + + Q++ + E H+ N++ E+ + ++A
Sbjct: 2195 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2241
Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
+ T A Q E L ++++QM++ LSK + + E+ NR
Sbjct: 2242 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2282
Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
L K Q+ LQ E++ + RL AQ+ R+ QL+ + LA
Sbjct: 2283 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2331
Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
EK+ +KE ++V ++ LK EA
Sbjct: 2332 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2356
Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
L ++Q+KE+ Q + + E + Q + E Q+ L++ + + + R K
Sbjct: 2357 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2414
Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
+ V + S E + +Q E+ +K L + +L +E ++
Sbjct: 2415 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2456
Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
L++T+E++ ++H +L + +L+ +Q+ AK KSE++ + QE
Sbjct: 2457 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2510
Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
L QE + L Q + E D+ + ++ ++ Q + V ++
Sbjct: 2511 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2556
Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
+ + + R + + Q+ Q + E R + + +R +++ QQ+++ + EE
Sbjct: 2557 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2613
Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
++ + N+ +E QL +++ H A+ +EV
Sbjct: 2614 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2642
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1200 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1259
Query: 639 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1260 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1319
Query: 690 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1320 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379
Query: 747 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1436
Query: 805 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
+ + + L++L +Q + S +I E I V+
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496
Query: 843 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1556
Query: 884 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615
Query: 936 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675
Query: 993 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1729
Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1730 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1778
Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1829
Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
+RL+ L E + + D + + + + L L+ +
Sbjct: 1830 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1869
Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1870 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1916
Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1917 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1970 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 2020
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 2021 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2074
Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2075 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2131
Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2132 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191
Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251
Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2252 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2308
Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2309 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2368
Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2369 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2427
Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2428 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2478
Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2533
Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2534 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2588
Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2589 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2639
Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2640 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2691
Query: 2086 DLMREYQNLKSAVSKVLENA 2105
E Q L + V E A
Sbjct: 2692 S-AEELQRLAQGHTTVDELA 2710
Score = 84.0 bits (206), Expect = 6e-15
Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)
Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
G+ E++R ++E+LK ++ +R E+ L +E + +A+ + E
Sbjct: 1099 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1152
Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
E K L + +AQ ++ Q T + ++ +E GE L + V+ +++
Sbjct: 1153 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1207
Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
+ QL +Q + + LE + Y + WL R + +
Sbjct: 1208 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1267
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
+ + +QL +A++EEI +++ Q I D+ +A+L+
Sbjct: 1268 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1327
Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
++V + YS + + + + + L++ + +Q +A
Sbjct: 1328 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1387
Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
L+ V+ LE Q ++A+A ++ K + ++ + S++
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1447
Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
+ ++Q +E I+ K QA+ + EEI+ ++ +L + A+ +LQ ++
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1507
Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
R E E A+ + QV+D + + +QA V E +++ + E+ K+
Sbjct: 1508 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1561
Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ L + L L R+ +++R R + + E E + S AE
Sbjct: 1562 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1615
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
TA +L +LQE A+ L+++ ++ + + E +E+ +RW +
Sbjct: 1616 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1666
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ ++ ++Q ++ ++ Q+ ++ E AE + +A +Q+ ++
Sbjct: 1667 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+E A+Q L R + G +RQ++++ L+ Q + + L
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
K +E L + +A + + K FRE L ++ ++ + A+
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1841
Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
+ + + A+ ++ EK +G+ L++ + L++ + RL+ L
Sbjct: 1842 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1896
Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
E R+ +E A H +ADI SEL Q ++ L Q + E
Sbjct: 1897 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1951
Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
+L L+ + + E++ + NA E L KE
Sbjct: 1952 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1991
Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
A L + L+ E + R + +V LA EE + Q +A L+EV L V+E
Sbjct: 1992 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2049
Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
+ +E + + L L + + Q E++ ++ Q+ + +
Sbjct: 2050 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2104
Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
QL + ++ + + E + AE + + A L+ S + + A
Sbjct: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2164
Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
L A ++A + Q+ Q L+ +A E ++++ Q + +
Sbjct: 2165 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224
Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
T+ ++L + L+R+KAE + ++EE+ +++ EE+ RI AL
Sbjct: 2225 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281
Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
++K+ + + + ++ E + L QEA R RQ ++ Q +
Sbjct: 2282 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2341
Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
Q Q A + L+ +EL Q L D E + L + F
Sbjct: 2342 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2401
Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
+ + + E L VA + + +ED ++ E +++ R A +V L+Q
Sbjct: 2402 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
Q HD ++ RE + EL + EK E LL+ S + E+ L E +AL
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520
Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
+S +S ++ +E++ ++LE+ D +KA R ++ + + + Q+++++
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2575
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
+ + + +A E + + Q++L ++ + ELL L+L ++Q
Sbjct: 2576 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
+ + ++ Q A T
Sbjct: 2632 HRAALAHSEEVTASQVAATKT 2652
Score = 72.8 bits (177), Expect = 1e-11
Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)
Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
Q+ + T L AQ A++ H+ V+++ +L W Q L R ++++ S S+ +
Sbjct: 890 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 941
Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
++ E R Q L S YQ L D G D + G C
Sbjct: 942 RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 988
Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
++ + L LE + +R Q SE D+ L++ + R T + +P +
Sbjct: 989 ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 1040
Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
E R+ E K EV+ + + + ++L L + A TLRSEL
Sbjct: 1041 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1097
Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
L + V+ L + ++KL + IS V+ E V++ E+ +K + A
Sbjct: 1098 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1149
Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
L+ K + +Q T D + + + +DVE +R +
Sbjct: 1150 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1204
Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
E++ + + WQ + + + LE L Y + L W + +R +Q +
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1263
Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
L D Q + + ++ ++ +E+IE++G
Sbjct: 1264 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1289
Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
V + + K ++ +++ + L + ++ +GS +Q VD
Sbjct: 1290 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1345
Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
L+ +L ++T+Q +K ++ETL +E + EE E+L
Sbjct: 1346 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1390
Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
+A L+ + + ++ A Q E EL + + + +E A D +
Sbjct: 1391 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1441
Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
++++ L L + E + Q A A A + +L + + + + L + T Q G
Sbjct: 1442 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1498
Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
+ E L+AL A EAE + QE E L+ Q+ S +
Sbjct: 1499 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
EL R+ + + Q + + Q E +L+ ++ Q LE +
Sbjct: 1543 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1600
Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
E +Q+++ E + + L+++ A +AE ++QQ + +R LE+
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660
Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
Q+ + L+L ++ Q A++++ + + R+ + E A + R E+
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1716
Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
+ + + Q R ++ E + LR + E G+Q
Sbjct: 1717 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1758
Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
L+ ELA +Q + +A+ + +E + +LA + + E A + E+ R+ +K Q L
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
EL E R + L + + + + + A+ ++ + E L +
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1877
Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
+ E + +++ RL E F + E E DI EE + +L+
Sbjct: 1878 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1926
Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
K E+ + ++ Q +Q+ E + KAS E A+ E+E +LG++ + L
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1986
Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
+L AAR ++L + A +++ K++++ E E A+
Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 2038
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
E ++ K+ E + L+ E+ S A L L + A ++QQ + L +
Sbjct: 2039 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
+ ++ + R + E R ++ E+ +ER AA E L
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2144
Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
K+ Q Q + E + K+ + A +L+Q ++ +
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2192
Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
+ + K F Q R++ + ++ LT + LQL +H + ++++LKA E
Sbjct: 2193 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2246
Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
+ +++E+ + Q E+L + ++A A+I + D +R+ QE ++++ ++
Sbjct: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306
Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
RL + E L++ +L + + A L ++ + + L L + L
Sbjct: 2307 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2365
Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
E++ R + R LE+ R L E + + LR A +S
Sbjct: 2366 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2420
Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
+ E ++ K ++ ++ +TE + K L+ + +I
Sbjct: 2421 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2480
Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
++R + KL++E + L L S E QT +Q + L +E + Q Q F
Sbjct: 2481 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2522
Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
S+ +S+ E+E +L++L + +L+ ++ ++ Q+ R+ ++ S+
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582
Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
+A+ R Q+ L Q+ + + LL E L++ L + H
Sbjct: 2583 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2632
Score = 66.6 bits (161), Expect = 1e-09
Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)
Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1169 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1221
Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1222 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1281
Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1282 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1341
Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1342 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1388
Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1389 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1443
Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1444 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1503
Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563
Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623
Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1624 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677
Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1678 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1731
Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1732 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780
Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
E + EM++ L + E K + + E ++ + A+ L
Sbjct: 1781 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1836
Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
E+++ + EE+ R + V + RL + E L ++E E E
Sbjct: 1837 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1894
Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
L++ R + Q +++ LAQ ++ S + + L +
Sbjct: 1895 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1954
Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
L E A + E E G + + + LR S + + LE+ RQ A ++ R
Sbjct: 1955 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 2008
Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
+ ++ E ++ E K ++ + + ++ +RL + ++E
Sbjct: 2009 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2062
Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
L + + E A A+ KE ++Q LQ+ Q L EE E+
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
R++ + Q+++ + L+++ + + + + +A+ + +R Q
Sbjct: 2123 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2181
Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
+ + + + +E+ + + L Q + L L LE D +KN + L
Sbjct: 2182 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2240
Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
AE + +Q Q++ EL ++++ L + ++
Sbjct: 2241 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2274
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 1006 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1053
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1054 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1111
Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1170
Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1171 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1212
Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1213 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1268
Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1269 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1321
Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1322 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1381
Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1382 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1441
Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1442 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1501
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1560
Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1561 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1615
Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1616 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1673
Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1674 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1734 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1792
Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1793 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1844
Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1845 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1894
Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1895 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1939
Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1940 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1972
Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1973 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2032
Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2090
Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2091 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2133
Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2188
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2189 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2241
Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2301
Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2302 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2353
Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2354 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2394
Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2395 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2448
Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2449 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2490
Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2491 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2532
Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2533 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2583
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
R QH + V++ +E L QQL++ LA +
Sbjct: 2584 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2618
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2619 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2672
Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2673 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2729
Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
E+L + A QRQ+ T L L+ Q
Sbjct: 2730 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2760
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 270 bits (690), Expect = 5e-71
Identities = 594/2883 (20%), Positives = 1115/2883 (38%), Gaps = 509/2883 (17%)
Query: 17 VMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLP 76
V ++ +DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP
Sbjct: 18 VREKYKDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLP 75
Query: 77 CEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIE 136
E+GR R H + N+ AL +L R++KLVNI + DIADG P + LGL+WTIIL+FQI
Sbjct: 76 REKGRM--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 133
Query: 137 ELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQT 196
++ S S D AK+ LL W Q
Sbjct: 134 DI----------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQ 162
Query: 197 GIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLL 256
G+ +F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG+ RLL
Sbjct: 163 GLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLL 222
Query: 257 DPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF---- 312
DPEDVDV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 223 DPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWM 281
Query: 313 --------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEM 360
+R F+E+++ QF E +L + ++ + YQS + ++
Sbjct: 282 RHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQL 341
Query: 361 KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYR 420
K H + GKL + L ++ R + ++ L G L +
Sbjct: 342 KVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQ 400
Query: 421 AEVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRA 462
A+ L+ ++ + + + A ++R L++ ++ Q ++R
Sbjct: 401 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRV 460
Query: 463 F--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLL 513
+ HE Y R G+ P Q+ V+ S ++E L+Y L
Sbjct: 461 YRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQ 512
Query: 514 SLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 561
LL E L S + G + Q ++ + + IE ++ E Q
Sbjct: 513 DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----Q 567
Query: 562 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EE 610
+ T Y G ++ K +N + A+ R+L S + + ++ EE
Sbjct: 568 LSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 625
Query: 611 VISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTA 659
V +W DR N A +++ LE EK + + +NA R P A
Sbjct: 626 VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 685
Query: 660 MNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT 719
+ +++++ C + LK+ N + + F +V++ A+
Sbjct: 686 LQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ--------------- 723
Query: 720 LSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQ 779
L +K S + ++ L+QD +D ++++ + K A + + P+
Sbjct: 724 LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPR 783
Query: 780 EEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSL 831
M + +++ + K EC QL+ P + ++ S S
Sbjct: 784 HPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSE 834
Query: 832 GKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKH 891
+ + ++ Q + ++ +T +E Q++ VTL + L H
Sbjct: 835 AAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-H 873
Query: 892 FDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 951
D L +A+QS+ + + R +K EE R L + Q L
Sbjct: 874 VDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLR 924
Query: 952 EKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KL 1004
+ D PE+ L E+ S C L + +QG QE R +
Sbjct: 925 DSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRC 971
Query: 1005 HKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKI 1057
+ KD LQ EA H L L +D E R EC + + K + EG K
Sbjct: 972 ISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKG 1025
Query: 1058 IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR 1117
+ RL E + LP P T LR+ ++ T
Sbjct: 1026 V-----------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLG 1058
Query: 1118 KLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAV 1167
KL + Y + S + +E QLK + K ++
Sbjct: 1059 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1118
Query: 1168 EEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALV 1218
+++R + T L+ L+ EV + E ++ + +A+L ++A++
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1178
Query: 1219 TLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQ 1272
++ L G ++Y + L + ++ QEQ A+ E L + Q
Sbjct: 1179 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1238
Query: 1273 QLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRG 1310
LL ++ +++ +R +Q I + E L +
Sbjct: 1239 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1298
Query: 1311 HEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFS 1370
+E L + L + + I TLR+ E E E Q ER
Sbjct: 1299 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER----- 1347
Query: 1371 SLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKE 1425
L + + LE+ ++ ++ QAE KE E+ + QQQ +SI+E
Sbjct: 1348 -LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406
Query: 1426 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1485
++++L + E +I+ + E I +L A E + ++
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQA 1463
Query: 1486 IKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQC 1542
++ +E E++ +EEA+ + V + +A++ ++++ E RE +
Sbjct: 1464 LRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1520
Query: 1543 LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL 1602
L+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1521 LQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA-------------- 1562
Query: 1603 ESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAH 1656
L S +F+ ++ S +E A+ Q E+ RRA+++ A E L
Sbjct: 1563 -ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619
Query: 1657 WQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1707
WQ RL+ E + L + EA+ E + A R G+ + Q E+
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELA 1676
Query: 1708 SQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEH 1767
Q + L + +A++ ++ ++ EQ +++ + L + + + + +
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736
Query: 1768 QQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------V 1813
Q+ + L +++ L+ E ++TSE S + R ++ A E
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1796
Query: 1814 ESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEE 1855
E K + Q + A KL ++G A ++ L + +AE+ E
Sbjct: 1797 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ER 1851
Query: 1856 ASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQN 1915
++ E L E H + I +L Q +A++S + + L+E L Q
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909
Query: 1916 AKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQ 1963
+ + + S + KA+ L++G S EQ A QL E ER +
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969
Query: 1964 NLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFN 2022
++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++L++
Sbjct: 1970 R--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026
Query: 2023 QLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCC 2082
+ K Q +K AFA V ++ L+ T + ++ + +G+
Sbjct: 2027 E--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAE 2070
Query: 2083 GLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKD 2141
E + + A + ++ V + E+ A ++ + A K+ + +
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130
Query: 2142 LDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDD 2201
++ + K+ ++ K E T L ++E+ + LR+ L D
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDH 2186
Query: 2202 VLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELH 2255
+ DE + A S ++ L + EEL K + E +N+AL L +
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD-- 2244
Query: 2256 SKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFIND 2315
K N + L + E + A L + A + ++A+ +D Q EK + +
Sbjct: 2245 -KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE 2300
Query: 2316 ITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
V+E+ A+ E + A ++ + +Q++ + ++ +
Sbjct: 2301 ---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357
Query: 2371 HSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK 2430
+LE A ++ E S+ QA +E ++ F + +E E + A +
Sbjct: 2358 RQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQ 2411
Query: 2431 ESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQI 2489
E ++ + HD + + +++++ + + + + QE + L L + + ++Q++
Sbjct: 2412 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE- 2468
Query: 2490 TKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQ 2548
Q L++ QALQ SE S + R + ++E+ F E + +++Q
Sbjct: 2469 ------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQ 2515
Query: 2549 HIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNL 2608
E++ + ++E L+A+ E ++R Q +EEG QE L
Sbjct: 2516 LREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------EL 2559
Query: 2609 LRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQ 2668
++ +++ + ++ +E++ L E LQ + +A LA +E S+ K L +
Sbjct: 2560 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGR 2616
Query: 2669 DIL 2671
D L
Sbjct: 2617 DAL 2619
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 235 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 294
Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 295 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 337
Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 338 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 386
Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 387 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 443
Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 444 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 500
Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 501 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 557
Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 558 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 609
Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 610 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 667
Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 668 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 725
Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 726 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 785
Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 786 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 840
Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
V + ++AQ + L L + +++ +++ L
Sbjct: 841 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 900
Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 901 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 960
Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 961 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1015
Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1016 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1073
Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1074 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1133
Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1134 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193
Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1194 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1253
Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1254 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1311
Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1312 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1367
Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
K + EV E D + +
Sbjct: 1368 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1405
Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
EE + +SE R + + ++I RLQ +A
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1450
Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1451 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1500
Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1501 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1555
Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615
Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
EL+ W L L L + +QK +A +E E E
Sbjct: 1616 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1656
Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1710
Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1711 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1767
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1768 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1820
Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1875
Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1876 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1917
Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1977
Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1978 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2036
Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2037 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2094 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2151
Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2152 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2211
Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271
Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2272 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2328
Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2383
Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2384 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2429
Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2430 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2470
Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2471 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2564
Score = 123 bits (309), Expect = 7e-27
Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)
Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 533 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 587
Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 588 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 643
Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
+ + EL + + +L G L E H A R T E
Sbjct: 644 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 682
Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 683 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 721
Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 722 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 761
Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 762 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 818
Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
++ + K S + A + A+E + ++E H + H+
Sbjct: 819 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 871
Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 872 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 931
Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 932 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 990
Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 991 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1049
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1050 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1097
Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1098 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1150
Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1151 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1210
Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1211 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1267
Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1268 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1327
Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
++ L R + E L V+ E Q ++ ++ Q + +QQ++Q
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1384
Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
+R + A + S Q+ ++Q S EA + RQ AE ++
Sbjct: 1385 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1431
Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
+ + + EE+ LE E + G + ELQ L+ R + + ++A
Sbjct: 1432 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1480
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
++E+L R Q+ + + EV L ++Q L L A E LR
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1540
Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
+ ++QV Q + L ++ Q E SL+++ A E
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1596
Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
+ R E+ ++++ W A E + R + + K + + +K EE
Sbjct: 1597 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656
Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
R + EE R +E+ ++ R + T Q R +A Q +Q +
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1716
Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
LEEE+ L+ ++ +T K + + ++ KV M EVLL
Sbjct: 1717 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1758
Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
+ +S EK ++ + E EA R R E+ + +L+ L +++ E+ A
Sbjct: 1759 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1811
Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
++ ++ + L + +A E + E ++ L EK+A+ + + L++
Sbjct: 1812 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1871
Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
H+ ++ +R+ ++ LE LV+D ++++I L++ ++ + E
Sbjct: 1872 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1931
Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
L + ED ++ E + + + E + + LA K
Sbjct: 1932 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1991
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
A +EE+ + ++ + + + A LQ ++ LQ + +++ Q+
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2047
Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
Q L+ LQ+ S D L+ + +A A + E Q A++ +QV+ L
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2107
Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
+EQA+ + L + + A+ Q EQT+ QK
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2167
Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
Q LT EE H K+ L D++LQ +K +E A SQV++
Sbjct: 2168 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2214
Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
+ SV +E+++KL + E+ E++ + + R +N +E+ ++
Sbjct: 2215 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2258
Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
+ + + V ++ LA D A+ A+ + LK+ A+QE K E
Sbjct: 2259 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2317
Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
L+ QK+ E +DKE + +Q + E + FQ LE +R++++S +
Sbjct: 2318 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376
Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
E++ Q+R +E + +Q I E L ++ + L+ L I S+ +A++ L
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2434
Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
+ I + +R L E +++Q + Q+ L+ + + LSEK L
Sbjct: 2435 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2489
Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
Q I+Q + K+ L D+V+K + + Q + + E L A E
Sbjct: 2490 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542
Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
+ E E K E L +L++ + + +L + + RL+E + L+ +H
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2591
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1122 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1168
Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1169 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220
Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1221 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1279
Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1280 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1335
Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
L E E+L+E +A + E + +A + K + + R
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1395
Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455
Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1511
Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1571
Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1572 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1691
Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1692 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1743
Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1744 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1801
Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1802 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1861
Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921
Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1981
Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 1982 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2030
Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2090
Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
+ + E L ++S EE + + A
Sbjct: 2091 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2125
Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
A +A+ QA ++ DA A Q + L
Sbjct: 2126 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183
Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2234
Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2235 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2293
Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2294 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2349
Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2350 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2392
Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2393 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2442
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2496
Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2497 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2552
Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2609
Query: 6406 ALLP 6409
LP
Sbjct: 2610 KTLP 2613
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1130
Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1131 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250
Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1251 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1310
Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1311 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1369
Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1370 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1426
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1427 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1474
Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1475 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1528
Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
++A+ A L EVE AE T L+ L
Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1585
Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
H +V + E E E+ + R + S+ Q
Sbjct: 1586 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1645
Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
A Q AER K +E E LE G Q+ + +I
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1705
Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1706 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1766 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1822
Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1823 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1877
Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937
Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
E +K++AE A + R+L K +L E+
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057
Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2058 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171
Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
L L EE Q + L+ + + S VEE LF
Sbjct: 2172 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2217
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
++ EE+ K K +NR +I L D
Sbjct: 2218 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2247
Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2248 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2307
Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2308 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356
Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2413
Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473
Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2474 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2508
Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2568
Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2569 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2619
Score = 104 bits (259), Expect = 4e-21
Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
L+TI+ + + E + E++L Q TL A K + Q T D
Sbjct: 1074 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1133
Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
+ AQ + + L E +++ R+ Q + W + + Q D+ L R
Sbjct: 1134 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193
Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
Q++++R + +L D + A + + Q + ++L Q Q L
Sbjct: 1194 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1241
Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
EEI+ ++ + A Q + +K EL+L + + V KK + + S
Sbjct: 1242 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1296
Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
+ I E V+ T + E+ L Q++ ++ ++ EE L Q+ + + +
Sbjct: 1297 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1349
Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
VE LEK LA + A++ A K+L +QE R+ A D + QK+ +
Sbjct: 1350 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405
Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
E L + E Q E+ ++E+ I+ ++Q+ T + EL ++
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1465
Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
+R +E E + Q AE L++ D +Q + + S ++A KQ L++
Sbjct: 1466 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1523
Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
L ++A+R + + + +Q AL AQ ++L +R + +EKT
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1576
Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
L Q ++H RE ++ + + A+ L+ +Q NE L
Sbjct: 1577 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1682
Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
Q + + EL A+ + +Q E L LQR
Sbjct: 1683 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1731
Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
E L +L + + V++A K +E+ ++ +E
Sbjct: 1732 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1783
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
EL + R+ + + + L+ +D R + +++A +GEA + + +
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1843
Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
+K L + + QR L E + E+ QL + S E Q
Sbjct: 1844 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1895
Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
+ E+TL +++ + A + + L R+ + ED + E
Sbjct: 1896 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1955
Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
AR + + + E + E E R+ +S+ + E +R +L+ + R+KA++
Sbjct: 1956 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2006
Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
L + QE R++Q+ QE Q K L + + H+ A
Sbjct: 2007 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2043
Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
+ + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A + VE AE
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2101
Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
+S E Q + E+L +++ EQ+ A R ++
Sbjct: 2102 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2139
Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2188
Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
N E++ L+ +A++ + + + S + + R A+++ IL D
Sbjct: 2189 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2245
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
D F +++ E + Q+ ++ S A L L E +L QQ++
Sbjct: 2246 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2295
Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
+ ++ + +Q+ A E L Q+ Q++ +QE D+E +
Sbjct: 2296 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2340
Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
Q+ Q T E +E+ A+ E L++ + E A Q K AEE
Sbjct: 2341 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2400
Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
EK + +EL+ Q +V L + Q Q + E+ + EL R+ +KL ++
Sbjct: 2401 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2453
Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
L +LK++ VQ +++L E S L E D+ +Q +F+EQ +L +
Sbjct: 2454 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2508
Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2559
Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
QL +Q + LL EE++ + +L+ + E+ L + V ++ + + GR+
Sbjct: 2560 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2618
Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2619 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2659
Score = 100 bits (248), Expect = 8e-20
Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)
Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 378 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 434
Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 435 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 487
Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 488 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 544
Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 545 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 599
Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 600 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 657
Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 658 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 714
Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 715 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 774
Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
+++ +L R G G E +L SH +L + +
Sbjct: 775 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 834
Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 835 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 892
Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 893 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 948
Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 949 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1004
Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1005 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1058
Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1059 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1118
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
K++ ++++ L A EV + + H E W++
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1173
Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1174 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1233
Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++ S
Sbjct: 1234 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1293
Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
G S +I+EY L S+ + Q + ++ ++ + + + +
Sbjct: 1294 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1348
Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
+EV +L+K Q +L ++ + + KE + +Q +V +E +
Sbjct: 1349 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1397
Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
+ L+ L+ Q + E+ A+ Q ++ ++ E R+ L + E+Q+
Sbjct: 1398 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1456
Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
LQ++ E Q + +E+A++L + Q S+ R +L+S+ A + +E
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1516
Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
K L + Q + L+ + + + L++ EA L K
Sbjct: 1517 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1567
Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
+ EK Q++ + + E QQQ ++ R + + E
Sbjct: 1568 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1615
Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
L +W + + + + + E+E+Q E + GKA+
Sbjct: 1616 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1666
Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
E V Q EL Q+L+++ + + A++ + ++L+RL E ++
Sbjct: 1667 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1710
Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
G++Q +L ++ + L+ +A ++L+ EL AE + LL S E
Sbjct: 1711 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762
Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
+ + + LE+ ++ + R + +L E+ +
Sbjct: 1763 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1820
Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
+ E L E +T + KE + ++++ E+ R +EE A+ + ++E
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880
Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
R + R + L+ L Q + +EEEI +L+ S ++ G +
Sbjct: 1881 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1933
Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
+ + DT + K+ LE + + + RE ER K L E EA R RK
Sbjct: 1934 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1991
Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
+ +E+LK R+ E + L LA+E + K + E
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2036
Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
K + A K + LQQT+ + + +R + EA E ++ ++ + + QS
Sbjct: 2037 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093
Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
Q + S E + + + +++ K Q + R + +
Sbjct: 2094 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2151
Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
++ HK E+ A E L L+++ + DH + L + LQ K
Sbjct: 2152 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2199
Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
A + A R +E EL + + L + +A + A + D + + + AE
Sbjct: 2200 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2258
Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
+KQV +E AR S+ A ++ A++ ++ + +K+++ + Q
Sbjct: 2259 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2305
Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
+E LK+E + LQ + Q RR E + +AQ + + + F + L++++
Sbjct: 2306 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364
Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
A + +V ++++ + E K+ + ++ +L Q +Q E +Q
Sbjct: 2365 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2423
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
R + HD + E +A + E + EA K L L +E + ++
Sbjct: 2424 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2471
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
Q+ + ++ L +K+ + ++ +EQ +LE L Q V ++L Q R Q+ M
Sbjct: 2472 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2527
Query: 4358 EWAEEQQPNIA 4368
E +E+Q +A
Sbjct: 2528 E--QERQRLVA 2536
Score = 98.6 bits (244), Expect = 2e-19
Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)
Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
H++ L K+ A E + E Q Q + LG + + L +AE L E S
Sbjct: 991 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1044
Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
+ L L+ SLS I + +T+ + +++ + L+ A+A
Sbjct: 1045 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1103
Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
+ + L+ + + L+ + Q+ + A D+L G EV ER+Q G + E +
Sbjct: 1104 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1162
Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
++++ +LL+ + + +TD +++ + L ++LR + + D L +
Sbjct: 1163 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1207
Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
WL+D ++ Q+ + P D + R ++ + L+ E +
Sbjct: 1208 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1248
Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
V + A I IKD E L + ++ + + S
Sbjct: 1249 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1285
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
KK V++ ES + +++D+ E + + L +E E +
Sbjct: 1286 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1339
Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
+ E ++ ++ L + L E ++ K +A R +EL ++ + E+ + E D
Sbjct: 1340 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1397
Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
Q + + ++L+ ++ +E + A++ Q E A+
Sbjct: 1398 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1432
Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
++++ ++ +L++ + + L +L + AE E L R +
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492
Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
+K +A +L S+ +A + + EK ++Q +E L A+ A + ++ +A
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1541
Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
++ + + ++ Q +A Q + +A + Q+ S+QE+ + + EE + +
Sbjct: 1542 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601
Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
Q + ++A ++ EL ++ ++ +L L E+ ++ + KQ E + E
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1660
Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
+ + + RE ++ ++ + L+E G Q Q L + Q L+R+ E
Sbjct: 1661 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1708
Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
+ Q+ + LEE L + R A A + + LE L+++ + E E
Sbjct: 1709 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1751
Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
V L + + E+ RS++++ ++ ++ + +E+ + A+ D
Sbjct: 1752 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1810
Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
++ + E + + ++ + + + LKEK + L+ + + R L
Sbjct: 1811 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870
Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
A+ + E+ + + + EL+ Q + +++ + EEI+ + A +
Sbjct: 1871 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1929
Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
+ S E+ R + + +A Q++L+ +E R R+ + + E
Sbjct: 1930 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 1987
Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
+ A+ E+ + +A R + ++S Q Q E ++ E+ + V Q
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
EQ L+Q T Q+ ++L+ + E +E +A +AE + Q+ E
Sbjct: 2048 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2099
Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
R + + + L +A + + Q Q R Q+ +A++
Sbjct: 2100 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2153
Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
K F Q + + + Q++ + E H+ N++ E+ + ++A
Sbjct: 2154 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2200
Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
+ T A Q E L ++++QM++ LSK + + E+ NR
Sbjct: 2201 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2241
Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
L K Q+ LQ E++ + RL AQ+ R+ QL+ + LA
Sbjct: 2242 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2290
Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
EK+ +KE ++V ++ LK EA
Sbjct: 2291 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2315
Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
L ++Q+KE+ Q + + E + Q + E Q+ L++ + + + R K
Sbjct: 2316 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2373
Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
+ V + S E + +Q E+ +K L + +L +E ++
Sbjct: 2374 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2415
Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
L++T+E++ ++H +L + +L+ +Q+ AK KSE++ + QE
Sbjct: 2416 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2469
Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
L QE + L Q + E D+ + ++ ++ Q + V ++
Sbjct: 2470 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2515
Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
+ + + R + + Q+ Q + E R + + +R +++ QQ+++ + EE
Sbjct: 2516 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2572
Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
++ + N+ +E QL +++ H A+ +EV
Sbjct: 2573 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2601
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1159 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1218
Query: 639 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1219 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1278
Query: 690 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1279 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338
Query: 747 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1395
Query: 805 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
+ + + L++L +Q + S +I E I V+
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455
Query: 843 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1515
Query: 884 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574
Query: 936 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634
Query: 993 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1688
Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1689 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1737
Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1788
Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
+RL+ L E + + D + + + + L L+ +
Sbjct: 1789 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1828
Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1829 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1875
Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1876 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1929 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1979
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1980 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2033
Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2034 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2090
Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2091 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150
Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210
Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2211 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2267
Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2268 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2327
Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2328 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2386
Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2387 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2437
Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2438 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2492
Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2493 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2547
Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2548 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2598
Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2599 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2650
Query: 2086 DLMREYQNLKSAVSKVLENA 2105
E Q L + V E A
Sbjct: 2651 S-AEELQRLAQGHTTVDELA 2669
Score = 84.0 bits (206), Expect = 6e-15
Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)
Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
G+ E++R ++E+LK ++ +R E+ L +E + +A+ + E
Sbjct: 1058 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1111
Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
E K L + +AQ ++ Q T + ++ +E GE L + V+ +++
Sbjct: 1112 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1166
Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
+ QL +Q + + LE + Y + WL R + +
Sbjct: 1167 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1226
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
+ + +QL +A++EEI +++ Q I D+ +A+L+
Sbjct: 1227 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1286
Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
++V + YS + + + + + L++ + +Q +A
Sbjct: 1287 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1346
Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
L+ V+ LE Q ++A+A ++ K + ++ + S++
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406
Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
+ ++Q +E I+ K QA+ + EEI+ ++ +L + A+ +LQ ++
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1466
Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
R E E A+ + QV+D + + +QA V E +++ + E+ K+
Sbjct: 1467 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1520
Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ L + L L R+ +++R R + + E E + S AE
Sbjct: 1521 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1574
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
TA +L +LQE A+ L+++ ++ + + E +E+ +RW +
Sbjct: 1575 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1625
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ ++ ++Q ++ ++ Q+ ++ E AE + +A +Q+ ++
Sbjct: 1626 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+E A+Q L R + G +RQ++++ L+ Q + + L
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
K +E L + +A + + K FRE L ++ ++ + A+
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1800
Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
+ + + A+ ++ EK +G+ L++ + L++ + RL+ L
Sbjct: 1801 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1855
Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
E R+ +E A H +ADI SEL Q ++ L Q + E
Sbjct: 1856 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1910
Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
+L L+ + + E++ + NA E L KE
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1950
Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
A L + L+ E + R + +V LA EE + Q +A L+EV L V+E
Sbjct: 1951 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2008
Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
+ +E + + L L + + Q E++ ++ Q+ + +
Sbjct: 2009 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2063
Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
QL + ++ + + E + AE + + A L+ S + + A
Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2123
Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
L A ++A + Q+ Q L+ +A E ++++ Q + +
Sbjct: 2124 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183
Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
T+ ++L + L+R+KAE + ++EE+ +++ EE+ RI AL
Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240
Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
++K+ + + + ++ E + L QEA R RQ ++ Q +
Sbjct: 2241 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2300
Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
Q Q A + L+ +EL Q L D E + L + F
Sbjct: 2301 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2360
Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
+ + + E L VA + + +ED ++ E +++ R A +V L+Q
Sbjct: 2361 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419
Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
Q HD ++ RE + EL + EK E LL+ S + E+ L E +AL
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479
Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
+S +S ++ +E++ ++LE+ D +KA R ++ + + + Q+++++
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2534
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
+ + + +A E + + Q++L ++ + ELL L+L ++Q
Sbjct: 2535 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
+ + ++ Q A T
Sbjct: 2591 HRAALAHSEEVTASQVAATKT 2611
Score = 72.8 bits (177), Expect = 1e-11
Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)
Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
Q+ + T L AQ A++ H+ V+++ +L W Q L R ++++ S S+ +
Sbjct: 849 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 900
Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
++ E R Q L S YQ L D G D + G C
Sbjct: 901 RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 947
Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
++ + L LE + +R Q SE D+ L++ + R T + +P +
Sbjct: 948 ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 999
Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
E R+ E K EV+ + + + ++L L + A TLRSEL
Sbjct: 1000 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1056
Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
L + V+ L + ++KL + IS V+ E V++ E+ +K + A
Sbjct: 1057 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1108
Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
L+ K + +Q T D + + + +DVE +R +
Sbjct: 1109 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1163
Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
E++ + + WQ + + + LE L Y + L W + +R +Q +
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1222
Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
L D Q + + ++ ++ +E+IE++G
Sbjct: 1223 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1248
Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
V + + K ++ +++ + L + ++ +GS +Q VD
Sbjct: 1249 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1304
Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
L+ +L ++T+Q +K ++ETL +E + EE E+L
Sbjct: 1305 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1349
Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
+A L+ + + ++ A Q E EL + + + +E A D +
Sbjct: 1350 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1400
Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
++++ L L + E + Q A A A + +L + + + + L + T Q G
Sbjct: 1401 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1457
Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
+ E L+AL A EAE + QE E L+ Q+ S +
Sbjct: 1458 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
EL R+ + + Q + + Q E +L+ ++ Q LE +
Sbjct: 1502 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1559
Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
E +Q+++ E + + L+++ A +AE ++QQ + +R LE+
Sbjct: 1560 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619
Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
Q+ + L+L ++ Q A++++ + + R+ + E A + R E+
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1675
Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
+ + + Q R ++ E + LR + E G+Q
Sbjct: 1676 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1717
Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
L+ ELA +Q + +A+ + +E + +LA + + E A + E+ R+ +K Q L
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777
Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
EL E R + L + + + + + A+ ++ + E L +
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1836
Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
+ E + +++ RL E F + E E DI EE + +L+
Sbjct: 1837 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1885
Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
K E+ + ++ Q +Q+ E + KAS E A+ E+E +LG++ + L
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1945
Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
+L AAR ++L + A +++ K++++ E E A+
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 1997
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
E ++ K+ E + L+ E+ S A L L + A ++QQ + L +
Sbjct: 1998 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
+ ++ + R + E R ++ E+ +ER AA E L
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2103
Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
K+ Q Q + E + K+ + A +L+Q ++ +
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2151
Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
+ + K F Q R++ + ++ LT + LQL +H + ++++LKA E
Sbjct: 2152 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2205
Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
+ +++E+ + Q E+L + ++A A+I + D +R+ QE ++++ ++
Sbjct: 2206 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265
Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
RL + E L++ +L + + A L ++ + + L L + L
Sbjct: 2266 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2324
Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
E++ R + R LE+ R L E + + LR A +S
Sbjct: 2325 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2379
Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
+ E ++ K ++ ++ +TE + K L+ + +I
Sbjct: 2380 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2439
Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
++R + KL++E + L L S E QT +Q + L +E + Q Q F
Sbjct: 2440 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2481
Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
S+ +S+ E+E +L++L + +L+ ++ ++ Q+ R+ ++ S+
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541
Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
+A+ R Q+ L Q+ + + LL E L++ L + H
Sbjct: 2542 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2591
Score = 66.6 bits (161), Expect = 1e-09
Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)
Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1128 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1180
Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1181 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1240
Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1241 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1300
Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1301 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1347
Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1348 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1402
Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1403 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1462
Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522
Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582
Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1583 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636
Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1637 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1690
Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1691 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739
Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
E + EM++ L + E K + + E ++ + A+ L
Sbjct: 1740 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1795
Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
E+++ + EE+ R + V + RL + E L ++E E E
Sbjct: 1796 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1853
Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
L++ R + Q +++ LAQ ++ S + + L +
Sbjct: 1854 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1913
Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
L E A + E E G + + + LR S + + LE+ RQ A ++ R
Sbjct: 1914 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1967
Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
+ ++ E ++ E K ++ + + ++ +RL + ++E
Sbjct: 1968 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2021
Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
L + + E A A+ KE ++Q LQ+ Q L EE E+
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081
Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
R++ + Q+++ + L+++ + + + + +A+ + +R Q
Sbjct: 2082 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2140
Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
+ + + + +E+ + + L Q + L L LE D +KN + L
Sbjct: 2141 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2199
Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
AE + +Q Q++ EL ++++ L + ++
Sbjct: 2200 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2233
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 965 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1012
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1013 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1070
Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1129
Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1130 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1171
Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1172 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1227
Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1228 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1280
Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1281 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1340
Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1341 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1400
Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1401 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1460
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1519
Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1520 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1574
Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1575 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1632
Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1633 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1693 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1751
Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1752 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1803
Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1804 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1853
Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1854 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1898
Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1899 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1931
Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1932 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1991
Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2049
Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2050 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2092
Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2147
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2148 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2200
Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2260
Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2261 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2312
Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2313 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2353
Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2354 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2407
Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2408 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2449
Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2450 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2491
Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2492 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2542
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
R QH + V++ +E L QQL++ LA +
Sbjct: 2543 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2577
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2578 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2631
Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2632 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2688
Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
E+L + A QRQ+ T L L+ Q
Sbjct: 2689 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2719
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 269 bits (688), Expect = 8e-71
Identities = 594/2878 (20%), Positives = 1112/2878 (38%), Gaps = 509/2878 (17%)
Query: 22 QDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGR 81
QDE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP E+GR
Sbjct: 37 QDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGR 94
Query: 82 RMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSN 141
R H + N+ AL +L R++KLVNI + DIADG P + LGL+WTIIL+FQI ++
Sbjct: 95 M--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI--- 149
Query: 142 LPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVK 201
S S D AK+ LL W Q G+
Sbjct: 150 -------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQGLRCD 181
Query: 202 DFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDV 261
+F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG+ RLLDPEDV
Sbjct: 182 NFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDV 241
Query: 262 DVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF--------- 312
DV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 242 DVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWMRHHTA 300
Query: 313 ---KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQI 365
+R F+E+++ QF E +L + ++ + YQS + ++K
Sbjct: 301 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 360
Query: 366 EHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVAL 425
H + GKL + L ++ R + ++ L G L +A+ L
Sbjct: 361 YHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL 419
Query: 426 REEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRAF--HE 465
+ ++ + + + A ++R L++ ++ Q ++R + HE
Sbjct: 420 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 479
Query: 466 -------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVL 518
Y R G+ P Q+ V+ S ++E L+Y L LL
Sbjct: 480 RLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQDLLAW 531
Query: 519 AESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQT 566
E L S + G + Q ++ + + IE ++ E Q+ T
Sbjct: 532 VEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----QLSPAT 586
Query: 567 AEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EEVISNW 615
Y G ++ K +N + A+ R+L S + + ++ EEV +W
Sbjct: 587 RGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 644
Query: 616 -DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTAMNDAG 664
DR N A +++ LE EK + + +NA R P A+
Sbjct: 645 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 704
Query: 665 NFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFA 724
+++++ C + LK+ N + + F +V++ A+ L
Sbjct: 705 SWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------------LQKLQ 742
Query: 725 TEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKE 784
+K S + ++ L+QD +D ++++ + K A + + P+
Sbjct: 743 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 802
Query: 785 MFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 836
M + +++ + K EC QL+ P + ++ S S +
Sbjct: 803 MRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSEAAVPS 853
Query: 837 IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 896
+ ++ Q + ++ +T +E Q++ VTL + L H D
Sbjct: 854 VCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-HVDMKS 892
Query: 897 LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGD- 955
L +A+QS+ + + R +K EE R L + Q L + D
Sbjct: 893 L--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLRDSQDA 943
Query: 956 ----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KLHKQWK 1009
PE+ L E+ S C L + +QG QE R + + K
Sbjct: 944 GGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRCISELK 990
Query: 1010 D--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKIIKEHR 1062
D LQ EA H L L +D E R EC + + K + EG K +
Sbjct: 991 DIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKGV---- 1040
Query: 1063 VFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMED 1122
RL E + LP P T LR+ ++ T KL +
Sbjct: 1041 -------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLGKLEQV 1077
Query: 1123 PDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRN 1172
Y + S + +E QLK + K +++++R
Sbjct: 1078 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1137
Query: 1173 GVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALVTLLSE 1223
+ T L+ L+ EV + E ++ + +A+L ++A++
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197
Query: 1224 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQQLLLH 1277
++ L G ++Y + L + ++ QEQ A+ E L + Q LL
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRGHEELR 1315
++ +++ +R +Q I + E L + +E
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317
Query: 1316 KLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESL 1375
L + L + + I TLR+ E E E Q ER L +
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER------LAEV 1365
Query: 1376 SSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKEQVKKL 1430
+ LE+ ++ ++ QAE KE E+ + QQQ +SI+E++++L
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 1431 EDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTI 1490
+ E +I+ + E I +L A E + ++ ++
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARA 1482
Query: 1491 QEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTI 1547
+E E++ +EEA+ + V + +A++ ++++ E RE + L+
Sbjct: 1483 EEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-- 1537
Query: 1548 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSS 1607
L L Q EE R+++Q+ E ++ V ++ + E L S
Sbjct: 1538 LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA---------------ELQS 1580
Query: 1608 AITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAHWQ--- 1658
+F+ ++ S +E A+ Q E+ RRA+++ A E L WQ
Sbjct: 1581 KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 1659 ------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
RL+ E + L + EA+ E + A R G+ + Q E+ Q
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELE 1695
Query: 1713 YSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDE 1772
+ L + +A++ ++ ++ EQ +++ + L + + + + + Q+ +
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 1773 LLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------VESKKG 1818
L +++ L+ E ++TSE S + R ++ A E E K
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815
Query: 1819 ELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEEASQVV 1860
+ Q + A KL ++G A ++ L + +AE+ E ++
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ERLRRLA 1870
Query: 1861 ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE 1920
E L E H + I +L Q +A++S + + L+E L Q + +
Sbjct: 1871 EDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928
Query: 1921 SAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQNLLGT 1968
+ S + KA+ L++G S EQ A QL E ER +
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EA 1986
Query: 1969 KQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDE 2027
++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++L++ +
Sbjct: 1987 EERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---- 2041
Query: 2028 LNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDL 2087
K Q +K AFA V ++ L+ T + ++ + +G+
Sbjct: 2042 ----------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089
Query: 2088 MREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFT 2146
E + + A + ++ V + E+ A ++ + A K+ + +
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 2147 SKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTR 2206
++ + K+ ++ K E T L ++E+ + LR+ L D +
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 2207 DEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELHSKVND 2260
DE + A S ++ L + EEL K + E +N+AL L + K N
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KDNT 2262
Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
+ L + E + A L + A + ++A+ +D Q EK + +
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE---KM 2316
Query: 2321 TKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL 2375
V+E+ A+ E + A ++ + +Q++ + ++ + +L
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 2376 ESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDR 2435
E A ++ E S+ QA +E ++ F + +E E + A +E
Sbjct: 2377 EMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 2436 TGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANE 2494
++ + HD + + +++++ + + + + QE + L L + + ++Q++
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE------ 2482
Query: 2495 EFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK 2553
Q L++ QALQ SE S + R + ++E+ F E + +++Q E+
Sbjct: 2483 -------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQLREEQ 2534
Query: 2554 KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTK 2613
+ + ++E L+A+ E ++R Q +EEG QE L ++ +
Sbjct: 2535 QRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ELQQLEQ 2578
Query: 2614 EKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL 2671
++ + ++ +E++ L E LQ + +A LA +E S+ K L +D L
Sbjct: 2579 QRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGRDAL 2633
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 249 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 308
Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 309 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 351
Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 352 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 400
Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 401 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457
Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 458 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 514
Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 515 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 571
Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 572 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 623
Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 624 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 681
Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 682 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 739
Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 740 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799
Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 800 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 854
Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
V + ++AQ + L L + +++ +++ L
Sbjct: 855 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 914
Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 915 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 974
Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 975 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1029
Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1030 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087
Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267
Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1268 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325
Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1381
Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
K + EV E D + +
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1419
Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
EE + +SE R + + ++I RLQ +A
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1464
Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1465 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1514
Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1515 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1569
Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
EL+ W L L L + +QK +A +E E E
Sbjct: 1630 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1670
Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1724
Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1781
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1834
Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1889
Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1890 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991
Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2050
Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2051 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2108 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165
Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2286 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342
Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2397
Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2398 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2443
Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2444 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2484
Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2485 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578
Score = 123 bits (309), Expect = 7e-27
Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)
Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 547 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 601
Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 602 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 657
Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
+ + EL + + +L G L E H A R T E
Sbjct: 658 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 696
Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 697 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 735
Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 736 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 775
Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 776 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 832
Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
++ + K S + A + A+E + ++E H + H+
Sbjct: 833 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 885
Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 886 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 945
Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 946 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1004
Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1063
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1111
Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1112 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1164
Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1165 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1224
Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1281
Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
++ L R + E L V+ E Q ++ ++ Q + +QQ++Q
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1398
Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
+R + A + S Q+ ++Q S EA + RQ AE ++
Sbjct: 1399 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1445
Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
+ + + EE+ LE E + G + ELQ L+ R + + ++A
Sbjct: 1446 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1494
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
++E+L R Q+ + + EV L ++Q L L A E LR
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
+ ++QV Q + L ++ Q E SL+++ A E
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1610
Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
+ R E+ ++++ W A E + R + + K + + +K EE
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
R + EE R +E+ ++ R + T Q R +A Q +Q +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
LEEE+ L+ ++ +T K + + ++ KV M EVLL
Sbjct: 1731 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1772
Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
+ +S EK ++ + E EA R R E+ + +L+ L +++ E+ A
Sbjct: 1773 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1825
Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
++ ++ + L + +A E + E ++ L EK+A+ + + L++
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885
Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
H+ ++ +R+ ++ LE LV+D ++++I L++ ++ + E
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1945
Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
L + ED ++ E + + + E + + LA K
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
A +EE+ + ++ + + + A LQ ++ LQ + +++ Q+
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2061
Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
Q L+ LQ+ S D L+ + +A A + E Q A++ +QV+ L
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
+EQA+ + L + + A+ Q EQT+ QK
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
Q LT EE H K+ L D++LQ +K +E A SQV++
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2228
Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
+ SV +E+++KL + E+ E++ + + R +N +E+ ++
Sbjct: 2229 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2272
Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
+ + + V ++ LA D A+ A+ + LK+ A+QE K E
Sbjct: 2273 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2331
Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
L+ QK+ E +DKE + +Q + E + FQ LE +R++++S +
Sbjct: 2332 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
E++ Q+R +E + +Q I E L ++ + L+ L I S+ +A++ L
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2448
Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
+ I + +R L E +++Q + Q+ L+ + + LSEK L
Sbjct: 2449 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2503
Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
Q I+Q + K+ L D+V+K + + Q + + E L A E
Sbjct: 2504 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
+ E E K E L +L++ + + +L + + RL+E + L+ +H
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2605
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1136 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1182
Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1183 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1235 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293
Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
L E E+L+E +A + E + +A + K + + R
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1525
Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705
Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1706 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1757
Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1815
Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 1996 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2044
Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
+ + E L ++S EE + + A
Sbjct: 2105 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2139
Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
A +A+ QA ++ DA A Q + L
Sbjct: 2140 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2248
Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2249 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2308 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2363
Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2364 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2406
Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2456
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2511 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2566
Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2623
Query: 6406 ALLP 6409
LP
Sbjct: 2624 KTLP 2627
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324
Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1384 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1441 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1488
Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1489 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1542
Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
++A+ A L EVE AE T L+ L
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1599
Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
H +V + E E E+ + R + S+ Q
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659
Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
A Q AER K +E E LE G Q+ + +I
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1836
Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1891
Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
E +K++AE A + R+L K +L E+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2072 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
L L EE Q + L+ + + S VEE LF
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2231
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
++ EE+ K K +NR +I L D
Sbjct: 2232 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2261
Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321
Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2322 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2488 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2522
Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633
Score = 104 bits (259), Expect = 4e-21
Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
L+TI+ + + E + E++L Q TL A K + Q T D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
+ AQ + + L E +++ R+ Q + W + + Q D+ L R
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
Q++++R + +L D + A + + Q + ++L Q Q L
Sbjct: 1208 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1255
Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
EEI+ ++ + A Q + +K EL+L + + V KK + + S
Sbjct: 1256 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310
Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
+ I E V+ T + E+ L Q++ ++ ++ EE L Q+ + + +
Sbjct: 1311 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1363
Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
VE LEK LA + A++ A K+L +QE R+ A D + QK+ +
Sbjct: 1364 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
E L + E Q E+ ++E+ I+ ++Q+ T + EL ++
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
+R +E E + Q AE L++ D +Q + + S ++A KQ L++
Sbjct: 1480 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
L ++A+R + + + +Q AL AQ ++L +R + +EKT
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1590
Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
L Q ++H RE ++ + + A+ L+ +Q NE L
Sbjct: 1591 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1696
Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
Q + + EL A+ + +Q E L LQR
Sbjct: 1697 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
E L +L + + V++A K +E+ ++ +E
Sbjct: 1746 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
EL + R+ + + + L+ +D R + +++A +GEA + + +
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857
Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
+K L + + QR L E + E+ QL + S E Q
Sbjct: 1858 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909
Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
+ E+TL +++ + A + + L R+ + ED + E
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969
Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
AR + + + E + E E R+ +S+ + E +R +L+ + R+KA++
Sbjct: 1970 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
L + QE R++Q+ QE Q K L + + H+ A
Sbjct: 2021 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2057
Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
+ + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A + VE AE
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2115
Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
+S E Q + E+L +++ EQ+ A R ++
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2153
Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2202
Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
N E++ L+ +A++ + + + S + + R A+++ IL D
Sbjct: 2203 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
D F +++ E + Q+ ++ S A L L E +L QQ++
Sbjct: 2260 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2309
Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
+ ++ + +Q+ A E L Q+ Q++ +QE D+E +
Sbjct: 2310 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2354
Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
Q+ Q T E +E+ A+ E L++ + E A Q K AEE
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
EK + +EL+ Q +V L + Q Q + E+ + EL R+ +KL ++
Sbjct: 2415 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467
Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
L +LK++ VQ +++L E S L E D+ +Q +F+EQ +L +
Sbjct: 2468 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2573
Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
QL +Q + LL EE++ + +L+ + E+ L + V ++ + + GR+
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2632
Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2633 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2673
Score = 100 bits (248), Expect = 8e-20
Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)
Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 392 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 448
Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 449 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 501
Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 502 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 558
Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 559 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 613
Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 614 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 671
Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 672 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 728
Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 729 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788
Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
+++ +L R G G E +L SH +L + +
Sbjct: 789 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848
Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 849 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 906
Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 907 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 962
Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 963 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1018
Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1072
Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
K++ ++++ L A EV + + H E W++
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1187
Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++ S
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307
Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
G S +I+EY L S+ + Q + ++ ++ + + + +
Sbjct: 1308 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
+EV +L+K Q +L ++ + + KE + +Q +V +E +
Sbjct: 1363 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1411
Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
+ L+ L+ Q + E+ A+ Q ++ ++ E R+ L + E+Q+
Sbjct: 1412 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
LQ++ E Q + +E+A++L + Q S+ R +L+S+ A + +E
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530
Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
K L + Q + L+ + + + L++ EA L K
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1581
Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
+ EK Q++ + + E QQQ ++ R + + E
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1629
Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
L +W + + + + + E+E+Q E + GKA+
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1680
Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
E V Q EL Q+L+++ + + A++ + ++L+RL E ++
Sbjct: 1681 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1724
Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
G++Q +L ++ + L+ +A ++L+ EL AE + LL S E
Sbjct: 1725 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
+ + + LE+ ++ + R + +L E+ +
Sbjct: 1777 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
+ E L E +T + KE + ++++ E+ R +EE A+ + ++E
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
R + R + L+ L Q + +EEEI +L+ S ++ G +
Sbjct: 1895 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1947
Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
+ + DT + K+ LE + + + RE ER K L E EA R RK
Sbjct: 1948 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
+ +E+LK R+ E + L LA+E + K + E
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2050
Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
K + A K + LQQT+ + + +R + EA E ++ ++ + + QS
Sbjct: 2051 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
Q + S E + + + +++ K Q + R + +
Sbjct: 2108 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165
Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
++ HK E+ A E L L+++ + DH + L + LQ K
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2213
Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
A + A R +E EL + + L + +A + A + D + + + AE
Sbjct: 2214 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272
Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
+KQV +E AR S+ A ++ A++ ++ + +K+++ + Q
Sbjct: 2273 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2319
Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
+E LK+E + LQ + Q RR E + +AQ + + + F + L++++
Sbjct: 2320 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
A + +V ++++ + E K+ + ++ +L Q +Q E +Q
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2437
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
R + HD + E +A + E + EA K L L +E + ++
Sbjct: 2438 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2485
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
Q+ + ++ L +K+ + ++ +EQ +LE L Q V ++L Q R Q+ M
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2541
Query: 4358 EWAEEQQPNIA 4368
E +E+Q +A
Sbjct: 2542 E--QERQRLVA 2550
Score = 98.6 bits (244), Expect = 2e-19
Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)
Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
H++ L K+ A E + E Q Q + LG + + L +AE L E S
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1058
Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
+ L L+ SLS I + +T+ + +++ + L+ A+A
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1117
Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
+ + L+ + + L+ + Q+ + A D+L G EV ER+Q G + E +
Sbjct: 1118 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
++++ +LL+ + + +TD +++ + L ++LR + + D L +
Sbjct: 1177 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1221
Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
WL+D ++ Q+ + P D + R ++ + L+ E +
Sbjct: 1222 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1262
Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
V + A I IKD E L + ++ + + S
Sbjct: 1263 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1299
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
KK V++ ES + +++D+ E + + L +E E +
Sbjct: 1300 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1353
Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
+ E ++ ++ L + L E ++ K +A R +EL ++ + E+ + E D
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1411
Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
Q + + ++L+ ++ +E + A++ Q E A+
Sbjct: 1412 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1446
Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
++++ ++ +L++ + + L +L + AE E L R +
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
+K +A +L S+ +A + + EK ++Q +E L A+ A + ++ +A
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1555
Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
++ + + ++ Q +A Q + +A + Q+ S+QE+ + + EE + +
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
Q + ++A ++ EL ++ ++ +L L E+ ++ + KQ E + E
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1674
Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
+ + + RE ++ ++ + L+E G Q Q L + Q L+R+ E
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1722
Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
+ Q+ + LEE L + R A A + + LE L+++ + E E
Sbjct: 1723 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1765
Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
V L + + E+ RS++++ ++ ++ + +E+ + A+ D
Sbjct: 1766 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824
Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
++ + E + + ++ + + + LKEK + L+ + + R L
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
A+ + E+ + + + EL+ Q + +++ + EEI+ + A +
Sbjct: 1885 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
+ S E+ R + + +A Q++L+ +E R R+ + + E
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 2001
Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
+ A+ E+ + +A R + ++S Q Q E ++ E+ + V Q
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
EQ L+Q T Q+ ++L+ + E +E +A +AE + Q+ E
Sbjct: 2062 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
R + + + L +A + + Q Q R Q+ +A++
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2167
Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
K F Q + + + Q++ + E H+ N++ E+ + ++A
Sbjct: 2168 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2214
Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
+ T A Q E L ++++QM++ LSK + + E+ NR
Sbjct: 2215 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2255
Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
L K Q+ LQ E++ + RL AQ+ R+ QL+ + LA
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2304
Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
EK+ +KE ++V ++ LK EA
Sbjct: 2305 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2329
Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
L ++Q+KE+ Q + + E + Q + E Q+ L++ + + + R K
Sbjct: 2330 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2387
Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
+ V + S E + +Q E+ +K L + +L +E ++
Sbjct: 2388 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2429
Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
L++T+E++ ++H +L + +L+ +Q+ AK KSE++ + QE
Sbjct: 2430 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2483
Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
L QE + L Q + E D+ + ++ ++ Q + V ++
Sbjct: 2484 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2529
Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
+ + + R + + Q+ Q + E R + + +R +++ QQ+++ + EE
Sbjct: 2530 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586
Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
++ + N+ +E QL +++ H A+ +EV
Sbjct: 2587 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2615
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1232
Query: 639 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1292
Query: 690 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 747 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1409
Query: 805 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
+ + + L++L +Q + S +I E I V+
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 843 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 884 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 936 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 993 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1703 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1751
Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1802
Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
+RL+ L E + + D + + + + L L+ +
Sbjct: 1803 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1842
Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1843 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1889
Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1890 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1943 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2047
Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2104
Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2282 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2400
Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2401 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2506
Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2561
Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2562 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612
Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2613 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2664
Query: 2086 DLMREYQNLKSAVSKVLENA 2105
E Q L + V E A
Sbjct: 2665 S-AEELQRLAQGHTTVDELA 2683
Score = 84.0 bits (206), Expect = 6e-15
Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)
Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
G+ E++R ++E+LK ++ +R E+ L +E + +A+ + E
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1125
Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
E K L + +AQ ++ Q T + ++ +E GE L + V+ +++
Sbjct: 1126 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180
Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
+ QL +Q + + LE + Y + WL R + +
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
+ + +QL +A++EEI +++ Q I D+ +A+L+
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300
Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
++V + YS + + + + + L++ + +Q +A
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360
Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
L+ V+ LE Q ++A+A ++ K + ++ + S++
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
+ ++Q +E I+ K QA+ + EEI+ ++ +L + A+ +LQ ++
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480
Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
R E E A+ + QV+D + + +QA V E +++ + E+ K+
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1534
Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ L + L L R+ +++R R + + E E + S AE
Sbjct: 1535 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1588
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
TA +L +LQE A+ L+++ ++ + + E +E+ +RW +
Sbjct: 1589 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1639
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ ++ ++Q ++ ++ Q+ ++ E AE + +A +Q+ ++
Sbjct: 1640 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+E A+Q L R + G +RQ++++ L+ Q + + L
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
K +E L + +A + + K FRE L ++ ++ + A+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1814
Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
+ + + A+ ++ EK +G+ L++ + L++ + RL+ L
Sbjct: 1815 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
E R+ +E A H +ADI SEL Q ++ L Q + E
Sbjct: 1870 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1924
Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
+L L+ + + E++ + NA E L KE
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1964
Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
A L + L+ E + R + +V LA EE + Q +A L+EV L V+E
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2022
Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
+ +E + + L L + + Q E++ ++ Q+ + +
Sbjct: 2023 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
QL + ++ + + E + AE + + A L+ S + + A
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
L A ++A + Q+ Q L+ +A E ++++ Q + +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
T+ ++L + L+R+KAE + ++EE+ +++ EE+ RI AL
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
++K+ + + + ++ E + L QEA R RQ ++ Q +
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
Q Q A + L+ +EL Q L D E + L + F
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
+ + + E L VA + + +ED ++ E +++ R A +V L+Q
Sbjct: 2375 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
Q HD ++ RE + EL + EK E LL+ S + E+ L E +AL
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
+S +S ++ +E++ ++LE+ D +KA R ++ + + + Q+++++
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2548
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
+ + + +A E + + Q++L ++ + ELL L+L ++Q
Sbjct: 2549 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
+ + ++ Q A T
Sbjct: 2605 HRAALAHSEEVTASQVAATKT 2625
Score = 72.8 bits (177), Expect = 1e-11
Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)
Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
Q+ + T L AQ A++ H+ V+++ +L W Q L R ++++ S S+ +
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 914
Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
++ E R Q L S YQ L D G D + G C
Sbjct: 915 RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 961
Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
++ + L LE + +R Q SE D+ L++ + R T + +P +
Sbjct: 962 ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 1013
Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
E R+ E K EV+ + + + ++L L + A TLRSEL
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1070
Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
L + V+ L + ++KL + IS V+ E V++ E+ +K + A
Sbjct: 1071 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122
Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
L+ K + +Q T D + + + +DVE +R +
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1177
Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
E++ + + WQ + + + LE L Y + L W + +R +Q +
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1236
Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
L D Q + + ++ ++ +E+IE++G
Sbjct: 1237 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1262
Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
V + + K ++ +++ + L + ++ +GS +Q VD
Sbjct: 1263 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1318
Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
L+ +L ++T+Q +K ++ETL +E + EE E+L
Sbjct: 1319 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1363
Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
+A L+ + + ++ A Q E EL + + + +E A D +
Sbjct: 1364 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1414
Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
++++ L L + E + Q A A A + +L + + + + L + T Q G
Sbjct: 1415 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1471
Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
+ E L+AL A EAE + QE E L+ Q+ S +
Sbjct: 1472 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
EL R+ + + Q + + Q E +L+ ++ Q LE +
Sbjct: 1516 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
E +Q+++ E + + L+++ A +AE ++QQ + +R LE+
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
Q+ + L+L ++ Q A++++ + + R+ + E A + R E+
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1689
Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
+ + + Q R ++ E + LR + E G+Q
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1731
Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
L+ ELA +Q + +A+ + +E + +LA + + E A + E+ R+ +K Q L
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
EL E R + L + + + + + A+ ++ + E L +
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1850
Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
+ E + +++ RL E F + E E DI EE + +L+
Sbjct: 1851 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1899
Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
K E+ + ++ Q +Q+ E + KAS E A+ E+E +LG++ + L
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
+L AAR ++L + A +++ K++++ E E A+
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 2011
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
E ++ K+ E + L+ E+ S A L L + A ++QQ + L +
Sbjct: 2012 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
+ ++ + R + E R ++ E+ +ER AA E L
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2117
Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
K+ Q Q + E + K+ + A +L+Q ++ +
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2165
Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
+ + K F Q R++ + ++ LT + LQL +H + ++++LKA E
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2219
Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
+ +++E+ + Q E+L + ++A A+I + D +R+ QE ++++ ++
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
RL + E L++ +L + + A L ++ + + L L + L
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2338
Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
E++ R + R LE+ R L E + + LR A +S
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2393
Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
+ E ++ K ++ ++ +TE + K L+ + +I
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453
Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
++R + KL++E + L L S E QT +Q + L +E + Q Q F
Sbjct: 2454 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2495
Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
S+ +S+ E+E +L++L + +L+ ++ ++ Q+ R+ ++ S+
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
+A+ R Q+ L Q+ + + LL E L++ L + H
Sbjct: 2556 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Score = 66.6 bits (161), Expect = 1e-09
Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)
Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1142 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194
Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1195 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1254
Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1255 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314
Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1361
Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1416
Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1597 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1651 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1704
Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1705 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
E + EM++ L + E K + + E ++ + A+ L
Sbjct: 1754 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1809
Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
E+++ + EE+ R + V + RL + E L ++E E E
Sbjct: 1810 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1867
Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
L++ R + Q +++ LAQ ++ S + + L +
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1927
Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
L E A + E E G + + + LR S + + LE+ RQ A ++ R
Sbjct: 1928 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1981
Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
+ ++ E ++ E K ++ + + ++ +RL + ++E
Sbjct: 1982 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2035
Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
L + + E A A+ KE ++Q LQ+ Q L EE E+
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
R++ + Q+++ + L+++ + + + + +A+ + +R Q
Sbjct: 2096 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
+ + + + +E+ + + L Q + L L LE D +KN + L
Sbjct: 2155 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
AE + +Q Q++ EL ++++ L + ++
Sbjct: 2214 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 979 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1026
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1027 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1084
Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1143
Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1185
Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1186 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1241
Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1294
Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1534 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1588
Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1589 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1646
Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1707 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1817
Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1818 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1867
Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1868 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1912
Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1913 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1945
Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2063
Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2064 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2106
Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2161
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2162 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2214
Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2275 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2326
Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2367
Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2368 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2421
Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2422 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2463
Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2464 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2505
Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2506 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2556
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
R QH + V++ +E L QQL++ LA +
Sbjct: 2557 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2591
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2592 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2645
Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2702
Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
E+L + A QRQ+ T L L+ Q
Sbjct: 2703 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2733
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 268 bits (686), Expect = 1e-70
Identities = 594/2882 (20%), Positives = 1114/2882 (38%), Gaps = 509/2882 (17%)
Query: 18 MQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPC 77
M+ + DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP
Sbjct: 1 MKIVPDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPR 58
Query: 78 EQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEE 137
E+GR R H + N+ AL +L R++KLVNI + DIADG P + LGL+WTIIL+FQI +
Sbjct: 59 EKGRM--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 116
Query: 138 LTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTG 197
+ S S D AK+ LL W Q G
Sbjct: 117 I----------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQG 145
Query: 198 IEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLD 257
+ +F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG+ RLLD
Sbjct: 146 LRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 205
Query: 258 PEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF----- 312
PEDVDV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 206 PEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWMR 264
Query: 313 -------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEMK 361
+R F+E+++ QF E +L + ++ + YQS + ++K
Sbjct: 265 HHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK 324
Query: 362 RKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRA 421
H + GKL + L ++ R + ++ L G L +A
Sbjct: 325 VPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQA 383
Query: 422 EVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRAF 463
+ L+ ++ + + + A ++R L++ ++ Q ++R +
Sbjct: 384 DALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY 443
Query: 464 --HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLS 514
HE Y R G+ P Q+ V+ S ++E L+Y L
Sbjct: 444 RLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQD 495
Query: 515 LLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 562
LL E L S + G + Q ++ + + IE ++ E Q+
Sbjct: 496 LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----QL 550
Query: 563 LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EEV 611
T Y G ++ K +N + A+ R+L S + + ++ EEV
Sbjct: 551 SPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEV 608
Query: 612 ISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTAM 660
+W DR N A +++ LE EK + + +NA R P A+
Sbjct: 609 GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAAL 668
Query: 661 NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTL 720
+++++ C + LK+ N + + F +V++ A+ L
Sbjct: 669 QTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------------L 706
Query: 721 SAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE 780
+K S + ++ L+QD +D ++++ + K A + + P+
Sbjct: 707 QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRH 766
Query: 781 EGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLG 832
M + +++ + K EC QL+ P + ++ S S
Sbjct: 767 PAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSEA 817
Query: 833 KINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHF 892
+ + ++ Q + ++ +T +E Q++ VTL + L H
Sbjct: 818 AVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-HV 856
Query: 893 DQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEE 952
D L +A+QS+ + + R +K EE R L + Q L +
Sbjct: 857 DMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLRD 907
Query: 953 KGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KLH 1005
D PE+ L E+ S C L + +QG QE R +
Sbjct: 908 SQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRCI 954
Query: 1006 KQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKII 1058
+ KD LQ EA H L L +D E R EC + + K + EG K +
Sbjct: 955 SELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKGV 1008
Query: 1059 KEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRK 1118
RL E + LP P T LR+ ++ T K
Sbjct: 1009 -----------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLGK 1041
Query: 1119 LMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAVE 1168
L + Y + S + +E QLK + K +++
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1101
Query: 1169 EIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALVT 1219
++R + T L+ L+ EV + E ++ + +A+L ++A++
Sbjct: 1102 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1161
Query: 1220 LLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQQ 1273
++ L G ++Y + L + ++ QEQ A+ E L + Q
Sbjct: 1162 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1221
Query: 1274 LLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRGH 1311
LL ++ +++ +R +Q I + E L +
Sbjct: 1222 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1281
Query: 1312 EELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSS 1371
+E L + L + + I TLR+ E E E Q ER
Sbjct: 1282 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER------ 1329
Query: 1372 LESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKEQ 1426
L + + LE+ ++ ++ QAE KE E+ + QQQ +SI+E+
Sbjct: 1330 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1389
Query: 1427 VKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQI 1486
+++L + E +I+ + E I +L A E + ++ +
Sbjct: 1390 LQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQAL 1446
Query: 1487 KVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQCL 1543
+ +E E++ +EEA+ + V + +A++ ++++ E RE + L
Sbjct: 1447 RARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1503
Query: 1544 EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE 1603
+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1504 QA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA--------------- 1544
Query: 1604 SLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAHW 1657
L S +F+ ++ S +E A+ Q E+ RRA+++ A E L W
Sbjct: 1545 ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1602
Query: 1658 Q---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVS 1708
Q RL+ E + L + EA+ E + A R G+ + Q E+
Sbjct: 1603 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELAE 1659
Query: 1709 QASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQ 1768
Q + L + +A++ ++ ++ EQ +++ + L + + + + + Q
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1719
Query: 1769 QFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------VE 1814
+ + L +++ L+ E ++TSE S + R ++ A E E
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779
Query: 1815 SKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEEA 1856
K + Q + A KL ++G A ++ L + +AE+ E
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ERL 1834
Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
++ E L E H + I +L Q +A++S + + L+E L Q
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1892
Query: 1917 KALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQN 1964
+ + + S + KA+ L++G S EQ A QL E ER +
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1952
Query: 1965 LLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQ 2023
++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++L++ +
Sbjct: 1953 --EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2009
Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCG 2083
K Q +K AFA V ++ L+ T + ++ + +G+
Sbjct: 2010 --------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEA 2053
Query: 2084 LIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDL 2142
E + + A + ++ V + E+ A ++ + A K+ + +
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2113
Query: 2143 DNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDV 2202
++ + K+ ++ K E T L ++E+ + LR+ L D
Sbjct: 2114 AARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDHQ 2169
Query: 2203 LSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELHS 2256
+ DE + A S ++ L + EEL K + E +N+AL L +
Sbjct: 2170 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--- 2226
Query: 2257 KVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDI 2316
K N + L + E + A L + A + ++A+ +D Q EK + +
Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE- 2282
Query: 2317 TTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKYH 2371
V+E+ A+ E + A ++ + +Q++ + ++ +
Sbjct: 2283 --KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340
Query: 2372 SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKE 2431
+LE A ++ E S+ QA +E ++ F + +E E + A +E
Sbjct: 2341 QRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQE 2394
Query: 2432 SSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQIT 2490
++ + HD + + +++++ + + + + QE + L L + + ++Q++
Sbjct: 2395 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE-- 2450
Query: 2491 KANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQH 2549
Q L++ QALQ SE S + R + ++E+ F E + +++Q
Sbjct: 2451 -----------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQL 2498
Query: 2550 IPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLL 2609
E++ + ++E L+A+ E ++R Q +EEG QE L
Sbjct: 2499 REEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ELQ 2542
Query: 2610 RMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD 2669
++ +++ + ++ +E++ L E LQ + +A LA +E S+ K L +D
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGRD 2599
Query: 2670 IL 2671
L
Sbjct: 2600 AL 2601
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 217 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 276
Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 277 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 319
Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 320 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 368
Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 369 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 425
Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 426 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 482
Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 483 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 539
Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 540 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 591
Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 592 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 649
Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 650 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 707
Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 708 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 767
Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 768 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 822
Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
V + ++AQ + L L + +++ +++ L
Sbjct: 823 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 882
Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 883 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 942
Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 943 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 997
Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 998 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1055
Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115
Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1116 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175
Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1176 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1235
Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1236 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1293
Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1294 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1349
Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
K + EV E D + +
Sbjct: 1350 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1387
Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
EE + +SE R + + ++I RLQ +A
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1432
Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1433 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1482
Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1483 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1537
Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597
Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
EL+ W L L L + +QK +A +E E E
Sbjct: 1598 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1638
Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1692
Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1693 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1749
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1750 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1802
Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1857
Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1858 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1899
Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1959
Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1960 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2018
Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2019 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2076 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2133
Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2193
Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253
Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2254 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2310
Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2365
Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2366 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2411
Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2412 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2452
Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2453 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2546
Score = 123 bits (309), Expect = 7e-27
Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)
Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 515 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 569
Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 570 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 625
Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
+ + EL + + +L G L E H A R T E
Sbjct: 626 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 664
Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 665 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 703
Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 704 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 743
Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 744 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 800
Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
++ + K S + A + A+E + ++E H + H+
Sbjct: 801 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 853
Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 854 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 913
Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 914 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 972
Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 973 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1031
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1032 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1079
Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1080 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1132
Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1133 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1192
Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1193 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1249
Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1250 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1309
Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
++ L R + E L V+ E Q ++ ++ Q + +QQ++Q
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1366
Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
+R + A + S Q+ ++Q S EA + RQ AE ++
Sbjct: 1367 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1413
Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
+ + + EE+ LE E + G + ELQ L+ R + + ++A
Sbjct: 1414 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1462
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
++E+L R Q+ + + EV L ++Q L L A E LR
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1522
Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
+ ++QV Q + L ++ Q E SL+++ A E
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1578
Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
+ R E+ ++++ W A E + R + + K + + +K EE
Sbjct: 1579 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638
Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
R + EE R +E+ ++ R + T Q R +A Q +Q +
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698
Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
LEEE+ L+ ++ +T K + + ++ KV M EVLL
Sbjct: 1699 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1740
Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
+ +S EK ++ + E EA R R E+ + +L+ L +++ E+ A
Sbjct: 1741 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1793
Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
++ ++ + L + +A E + E ++ L EK+A+ + + L++
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1853
Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
H+ ++ +R+ ++ LE LV+D ++++I L++ ++ + E
Sbjct: 1854 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1913
Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
L + ED ++ E + + + E + + LA K
Sbjct: 1914 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1973
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
A +EE+ + ++ + + + A LQ ++ LQ + +++ Q+
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2029
Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
Q L+ LQ+ S D L+ + +A A + E Q A++ +QV+ L
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089
Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
+EQA+ + L + + A+ Q EQT+ QK
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2149
Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
Q LT EE H K+ L D++LQ +K +E A SQV++
Sbjct: 2150 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2196
Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
+ SV +E+++KL + E+ E++ + + R +N +E+ ++
Sbjct: 2197 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2240
Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
+ + + V ++ LA D A+ A+ + LK+ A+QE K E
Sbjct: 2241 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2299
Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
L+ QK+ E +DKE + +Q + E + FQ LE +R++++S +
Sbjct: 2300 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358
Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
E++ Q+R +E + +Q I E L ++ + L+ L I S+ +A++ L
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2416
Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
+ I + +R L E +++Q + Q+ L+ + + LSEK L
Sbjct: 2417 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2471
Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
Q I+Q + K+ L D+V+K + + Q + + E L A E
Sbjct: 2472 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524
Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
+ E E K E L +L++ + + +L + + RL+E + L+ +H
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2573
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1104 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1150
Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1151 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202
Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1203 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1261
Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1262 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1317
Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
L E E+L+E +A + E + +A + K + + R
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1377
Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437
Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1493
Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553
Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1673
Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1674 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1725
Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1783
Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1784 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843
Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903
Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963
Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 1964 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2012
Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2072
Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
+ + E L ++S EE + + A
Sbjct: 2073 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2107
Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
A +A+ QA ++ DA A Q + L
Sbjct: 2108 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165
Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2216
Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2217 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2275
Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2276 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2331
Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2332 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2374
Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2375 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2424
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2478
Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2479 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2534
Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2591
Query: 6406 ALLP 6409
LP
Sbjct: 2592 KTLP 2595
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1053 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1112
Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1113 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232
Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1233 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1292
Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1293 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1351
Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1352 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1408
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1409 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1456
Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1457 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1510
Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
++A+ A L EVE AE T L+ L
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1567
Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
H +V + E E E+ + R + S+ Q
Sbjct: 1568 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1627
Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
A Q AER K +E E LE G Q+ + +I
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1687
Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1688 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1748 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1804
Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1859
Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919
Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
E +K++AE A + R+L K +L E+
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039
Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2040 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153
Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
L L EE Q + L+ + + S VEE LF
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2199
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
++ EE+ K K +NR +I L D
Sbjct: 2200 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2229
Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2230 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2289
Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2290 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338
Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2395
Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455
Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2456 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2490
Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2550
Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2551 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2601
Score = 104 bits (259), Expect = 4e-21
Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
L+TI+ + + E + E++L Q TL A K + Q T D
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115
Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
+ AQ + + L E +++ R+ Q + W + + Q D+ L R
Sbjct: 1116 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175
Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
Q++++R + +L D + A + + Q + ++L Q Q L
Sbjct: 1176 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1223
Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
EEI+ ++ + A Q + +K EL+L + + V KK + + S
Sbjct: 1224 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1278
Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
+ I E V+ T + E+ L Q++ ++ ++ EE L Q+ + + +
Sbjct: 1279 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1331
Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
VE LEK LA + A++ A K+L +QE R+ A D + QK+ +
Sbjct: 1332 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
E L + E Q E+ ++E+ I+ ++Q+ T + EL ++
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447
Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
+R +E E + Q AE L++ D +Q + + S ++A KQ L++
Sbjct: 1448 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1505
Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
L ++A+R + + + +Q AL AQ ++L +R + +EKT
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1558
Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
L Q ++H RE ++ + + A+ L+ +Q NE L
Sbjct: 1559 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1664
Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
Q + + EL A+ + +Q E L LQR
Sbjct: 1665 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1713
Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
E L +L + + V++A K +E+ ++ +E
Sbjct: 1714 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1765
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
EL + R+ + + + L+ +D R + +++A +GEA + + +
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1825
Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
+K L + + QR L E + E+ QL + S E Q
Sbjct: 1826 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1877
Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
+ E+TL +++ + A + + L R+ + ED + E
Sbjct: 1878 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1937
Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
AR + + + E + E E R+ +S+ + E +R +L+ + R+KA++
Sbjct: 1938 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1988
Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
L + QE R++Q+ QE Q K L + + H+ A
Sbjct: 1989 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2025
Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
+ + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A + VE AE
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2083
Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
+S E Q + E+L +++ EQ+ A R ++
Sbjct: 2084 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2121
Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2170
Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
N E++ L+ +A++ + + + S + + R A+++ IL D
Sbjct: 2171 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2227
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
D F +++ E + Q+ ++ S A L L E +L QQ++
Sbjct: 2228 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2277
Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
+ ++ + +Q+ A E L Q+ Q++ +QE D+E +
Sbjct: 2278 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2322
Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
Q+ Q T E +E+ A+ E L++ + E A Q K AEE
Sbjct: 2323 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382
Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
EK + +EL+ Q +V L + Q Q + E+ + EL R+ +KL ++
Sbjct: 2383 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2435
Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
L +LK++ VQ +++L E S L E D+ +Q +F+EQ +L +
Sbjct: 2436 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2490
Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2541
Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
QL +Q + LL EE++ + +L+ + E+ L + V ++ + + GR+
Sbjct: 2542 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2600
Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2601 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2641
Score = 100 bits (248), Expect = 8e-20
Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)
Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 360 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 416
Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 417 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 469
Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 470 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 526
Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 527 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 581
Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 582 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 639
Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 640 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 696
Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 697 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 756
Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
+++ +L R G G E +L SH +L + +
Sbjct: 757 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 816
Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 817 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 874
Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 875 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 930
Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 931 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 986
Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 987 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1040
Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1041 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1100
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
K++ ++++ L A EV + + H E W++
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1155
Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215
Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++ S
Sbjct: 1216 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1275
Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
G S +I+EY L S+ + Q + ++ ++ + + + +
Sbjct: 1276 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330
Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
+EV +L+K Q +L ++ + + KE + +Q +V +E +
Sbjct: 1331 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1379
Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
+ L+ L+ Q + E+ A+ Q ++ ++ E R+ L + E+Q+
Sbjct: 1380 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1438
Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
LQ++ E Q + +E+A++L + Q S+ R +L+S+ A + +E
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1498
Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
K L + Q + L+ + + + L++ EA L K
Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1549
Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
+ EK Q++ + + E QQQ ++ R + + E
Sbjct: 1550 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1597
Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
L +W + + + + + E+E+Q E + GKA+
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1648
Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
E V Q EL Q+L+++ + + A++ + ++L+RL E ++
Sbjct: 1649 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1692
Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
G++Q +L ++ + L+ +A ++L+ EL AE + LL S E
Sbjct: 1693 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744
Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
+ + + LE+ ++ + R + +L E+ +
Sbjct: 1745 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802
Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
+ E L E +T + KE + ++++ E+ R +EE A+ + ++E
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862
Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
R + R + L+ L Q + +EEEI +L+ S ++ G +
Sbjct: 1863 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1915
Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
+ + DT + K+ LE + + + RE ER K L E EA R RK
Sbjct: 1916 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1973
Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
+ +E+LK R+ E + L LA+E + K + E
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2018
Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
K + A K + LQQT+ + + +R + EA E ++ ++ + + QS
Sbjct: 2019 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075
Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
Q + S E + + + +++ K Q + R + +
Sbjct: 2076 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2133
Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
++ HK E+ A E L L+++ + DH + L + LQ K
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2181
Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
A + A R +E EL + + L + +A + A + D + + + AE
Sbjct: 2182 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2240
Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
+KQV +E AR S+ A ++ A++ ++ + +K+++ + Q
Sbjct: 2241 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2287
Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
+E LK+E + LQ + Q RR E + +AQ + + + F + L++++
Sbjct: 2288 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346
Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
A + +V ++++ + E K+ + ++ +L Q +Q E +Q
Sbjct: 2347 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2405
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
R + HD + E +A + E + EA K L L +E + ++
Sbjct: 2406 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2453
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
Q+ + ++ L +K+ + ++ +EQ +LE L Q V ++L Q R Q+ M
Sbjct: 2454 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2509
Query: 4358 EWAEEQQPNIA 4368
E +E+Q +A
Sbjct: 2510 E--QERQRLVA 2518
Score = 98.6 bits (244), Expect = 2e-19
Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)
Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
H++ L K+ A E + E Q Q + LG + + L +AE L E S
Sbjct: 973 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1026
Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
+ L L+ SLS I + +T+ + +++ + L+ A+A
Sbjct: 1027 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1085
Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
+ + L+ + + L+ + Q+ + A D+L G EV ER+Q G + E +
Sbjct: 1086 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1144
Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
++++ +LL+ + + +TD +++ + L ++LR + + D L +
Sbjct: 1145 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1189
Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
WL+D ++ Q+ + P D + R ++ + L+ E +
Sbjct: 1190 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1230
Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
V + A I IKD E L + ++ + + S
Sbjct: 1231 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1267
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
KK V++ ES + +++D+ E + + L +E E +
Sbjct: 1268 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1321
Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
+ E ++ ++ L + L E ++ K +A R +EL ++ + E+ + E D
Sbjct: 1322 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1379
Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
Q + + ++L+ ++ +E + A++ Q E A+
Sbjct: 1380 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1414
Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
++++ ++ +L++ + + L +L + AE E L R +
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474
Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
+K +A +L S+ +A + + EK ++Q +E L A+ A + ++ +A
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1523
Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
++ + + ++ Q +A Q + +A + Q+ S+QE+ + + EE + +
Sbjct: 1524 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583
Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
Q + ++A ++ EL ++ ++ +L L E+ ++ + KQ E + E
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1642
Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
+ + + RE ++ ++ + L+E G Q Q L + Q L+R+ E
Sbjct: 1643 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1690
Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
+ Q+ + LEE L + R A A + + LE L+++ + E E
Sbjct: 1691 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1733
Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
V L + + E+ RS++++ ++ ++ + +E+ + A+ D
Sbjct: 1734 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1792
Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
++ + E + + ++ + + + LKEK + L+ + + R L
Sbjct: 1793 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
A+ + E+ + + + EL+ Q + +++ + EEI+ + A +
Sbjct: 1853 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1911
Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
+ S E+ R + + +A Q++L+ +E R R+ + + E
Sbjct: 1912 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 1969
Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
+ A+ E+ + +A R + ++S Q Q E ++ E+ + V Q
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
EQ L+Q T Q+ ++L+ + E +E +A +AE + Q+ E
Sbjct: 2030 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2081
Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
R + + + L +A + + Q Q R Q+ +A++
Sbjct: 2082 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2135
Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
K F Q + + + Q++ + E H+ N++ E+ + ++A
Sbjct: 2136 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2182
Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
+ T A Q E L ++++QM++ LSK + + E+ NR
Sbjct: 2183 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2223
Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
L K Q+ LQ E++ + RL AQ+ R+ QL+ + LA
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2272
Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
EK+ +KE ++V ++ LK EA
Sbjct: 2273 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2297
Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
L ++Q+KE+ Q + + E + Q + E Q+ L++ + + + R K
Sbjct: 2298 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2355
Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
+ V + S E + +Q E+ +K L + +L +E ++
Sbjct: 2356 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2397
Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
L++T+E++ ++H +L + +L+ +Q+ AK KSE++ + QE
Sbjct: 2398 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2451
Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
L QE + L Q + E D+ + ++ ++ Q + V ++
Sbjct: 2452 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2497
Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
+ + + R + + Q+ Q + E R + + +R +++ QQ+++ + EE
Sbjct: 2498 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2554
Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
++ + N+ +E QL +++ H A+ +EV
Sbjct: 2555 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2583
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1141 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1200
Query: 639 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1201 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1260
Query: 690 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1261 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1320
Query: 747 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1377
Query: 805 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
+ + + L++L +Q + S +I E I V+
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437
Query: 843 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1497
Query: 884 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556
Query: 936 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616
Query: 993 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1670
Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1671 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1719
Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1770
Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
+RL+ L E + + D + + + + L L+ +
Sbjct: 1771 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1810
Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1811 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1857
Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1858 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1911 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1961
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2015
Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2016 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2072
Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2073 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132
Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192
Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2193 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2249
Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2250 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2309
Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2310 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2368
Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2369 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2419
Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2420 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2474
Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2475 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2529
Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2530 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2580
Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2581 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2632
Query: 2086 DLMREYQNLKSAVSKVLENA 2105
E Q L + V E A
Sbjct: 2633 S-AEELQRLAQGHTTVDELA 2651
Score = 84.0 bits (206), Expect = 6e-15
Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)
Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
G+ E++R ++E+LK ++ +R E+ L +E + +A+ + E
Sbjct: 1040 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1093
Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
E K L + +AQ ++ Q T + ++ +E GE L + V+ +++
Sbjct: 1094 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1148
Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
+ QL +Q + + LE + Y + WL R + +
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1208
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
+ + +QL +A++EEI +++ Q I D+ +A+L+
Sbjct: 1209 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1268
Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
++V + YS + + + + + L++ + +Q +A
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1328
Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
L+ V+ LE Q ++A+A ++ K + ++ + S++
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1388
Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
+ ++Q +E I+ K QA+ + EEI+ ++ +L + A+ +LQ ++
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1448
Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
R E E A+ + QV+D + + +QA V E +++ + E+ K+
Sbjct: 1449 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1502
Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ L + L L R+ +++R R + + E E + S AE
Sbjct: 1503 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1556
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
TA +L +LQE A+ L+++ ++ + + E +E+ +RW +
Sbjct: 1557 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1607
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ ++ ++Q ++ ++ Q+ ++ E AE + +A +Q+ ++
Sbjct: 1608 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+E A+Q L R + G +RQ++++ L+ Q + + L
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
K +E L + +A + + K FRE L ++ ++ + A+
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1782
Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
+ + + A+ ++ EK +G+ L++ + L++ + RL+ L
Sbjct: 1783 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1837
Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
E R+ +E A H +ADI SEL Q ++ L Q + E
Sbjct: 1838 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1892
Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
+L L+ + + E++ + NA E L KE
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1932
Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
A L + L+ E + R + +V LA EE + Q +A L+EV L V+E
Sbjct: 1933 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 1990
Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
+ +E + + L L + + Q E++ ++ Q+ + +
Sbjct: 1991 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2045
Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
QL + ++ + + E + AE + + A L+ S + + A
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105
Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
L A ++A + Q+ Q L+ +A E ++++ Q + +
Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165
Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
T+ ++L + L+R+KAE + ++EE+ +++ EE+ RI AL
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222
Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
++K+ + + + ++ E + L QEA R RQ ++ Q +
Sbjct: 2223 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2282
Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
Q Q A + L+ +EL Q L D E + L + F
Sbjct: 2283 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2342
Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
+ + + E L VA + + +ED ++ E +++ R A +V L+Q
Sbjct: 2343 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401
Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
Q HD ++ RE + EL + EK E LL+ S + E+ L E +AL
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461
Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
+S +S ++ +E++ ++LE+ D +KA R ++ + + + Q+++++
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2516
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
+ + + +A E + + Q++L ++ + ELL L+L ++Q
Sbjct: 2517 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
+ + ++ Q A T
Sbjct: 2573 HRAALAHSEEVTASQVAATKT 2593
Score = 72.8 bits (177), Expect = 1e-11
Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)
Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
Q+ + T L AQ A++ H+ V+++ +L W Q L R ++++ S S+ +
Sbjct: 831 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 882
Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
++ E R Q L S YQ L D G D + G C
Sbjct: 883 RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 929
Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
++ + L LE + +R Q SE D+ L++ + R T + +P +
Sbjct: 930 ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 981
Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
E R+ E K EV+ + + + ++L L + A TLRSEL
Sbjct: 982 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1038
Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
L + V+ L + ++KL + IS V+ E V++ E+ +K + A
Sbjct: 1039 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1090
Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
L+ K + +Q T D + + + +DVE +R +
Sbjct: 1091 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1145
Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
E++ + + WQ + + + LE L Y + L W + +R +Q +
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1204
Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
L D Q + + ++ ++ +E+IE++G
Sbjct: 1205 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1230
Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
V + + K ++ +++ + L + ++ +GS +Q VD
Sbjct: 1231 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1286
Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
L+ +L ++T+Q +K ++ETL +E + EE E+L
Sbjct: 1287 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1331
Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
+A L+ + + ++ A Q E EL + + + +E A D +
Sbjct: 1332 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1382
Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
++++ L L + E + Q A A A + +L + + + + L + T Q G
Sbjct: 1383 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1439
Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
+ E L+AL A EAE + QE E L+ Q+ S +
Sbjct: 1440 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
EL R+ + + Q + + Q E +L+ ++ Q LE +
Sbjct: 1484 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1541
Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
E +Q+++ E + + L+++ A +AE ++QQ + +R LE+
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
Q+ + L+L ++ Q A++++ + + R+ + E A + R E+
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1657
Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
+ + + Q R ++ E + LR + E G+Q
Sbjct: 1658 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1699
Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
L+ ELA +Q + +A+ + +E + +LA + + E A + E+ R+ +K Q L
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759
Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
EL E R + L + + + + + A+ ++ + E L +
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1818
Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
+ E + +++ RL E F + E E DI EE + +L+
Sbjct: 1819 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1867
Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
K E+ + ++ Q +Q+ E + KAS E A+ E+E +LG++ + L
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927
Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
+L AAR ++L + A +++ K++++ E E A+
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 1979
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
E ++ K+ E + L+ E+ S A L L + A ++QQ + L +
Sbjct: 1980 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
+ ++ + R + E R ++ E+ +ER AA E L
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2085
Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
K+ Q Q + E + K+ + A +L+Q ++ +
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2133
Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
+ + K F Q R++ + ++ LT + LQL +H + ++++LKA E
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2187
Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
+ +++E+ + Q E+L + ++A A+I + D +R+ QE ++++ ++
Sbjct: 2188 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247
Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
RL + E L++ +L + + A L ++ + + L L + L
Sbjct: 2248 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2306
Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
E++ R + R LE+ R L E + + LR A +S
Sbjct: 2307 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2361
Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
+ E ++ K ++ ++ +TE + K L+ + +I
Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2421
Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
++R + KL++E + L L S E QT +Q + L +E + Q Q F
Sbjct: 2422 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2463
Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
S+ +S+ E+E +L++L + +L+ ++ ++ Q+ R+ ++ S+
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523
Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
+A+ R Q+ L Q+ + + LL E L++ L + H
Sbjct: 2524 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2573
Score = 66.6 bits (161), Expect = 1e-09
Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)
Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1110 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1162
Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1163 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1222
Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1223 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1282
Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1283 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1329
Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1330 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1384
Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1385 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1444
Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1565 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618
Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1619 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1672
Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1673 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
E + EM++ L + E K + + E ++ + A+ L
Sbjct: 1722 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1777
Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
E+++ + EE+ R + V + RL + E L ++E E E
Sbjct: 1778 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1835
Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
L++ R + Q +++ LAQ ++ S + + L +
Sbjct: 1836 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1895
Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
L E A + E E G + + + LR S + + LE+ RQ A ++ R
Sbjct: 1896 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1949
Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
+ ++ E ++ E K ++ + + ++ +RL + ++E
Sbjct: 1950 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2003
Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
L + + E A A+ KE ++Q LQ+ Q L EE E+
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063
Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
R++ + Q+++ + L+++ + + + + +A+ + +R Q
Sbjct: 2064 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2122
Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
+ + + + +E+ + + L Q + L L LE D +KN + L
Sbjct: 2123 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2181
Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
AE + +Q Q++ EL ++++ L + ++
Sbjct: 2182 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2215
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 947 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 994
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 995 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1052
Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1053 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1111
Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1112 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1153
Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1154 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1209
Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1210 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1262
Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1263 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1322
Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1323 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1382
Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1501
Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1502 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1556
Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1557 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1614
Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1615 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1675 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1733
Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1734 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1785
Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1786 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1835
Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1836 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1880
Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1881 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1913
Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1914 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1973
Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2031
Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2032 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2074
Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2129
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2130 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2182
Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2242
Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2243 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2294
Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2295 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2335
Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2336 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2389
Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2390 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2431
Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2432 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2473
Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2474 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2524
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
R QH + V++ +E L QQL++ LA +
Sbjct: 2525 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2559
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2560 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2613
Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2614 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2670
Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
E+L + A QRQ+ T L L+ Q
Sbjct: 2671 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2701
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 268 bits (684), Expect = 2e-70
Identities = 593/2878 (20%), Positives = 1112/2878 (38%), Gaps = 509/2878 (17%)
Query: 22 QDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGR 81
+DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP E+GR
Sbjct: 37 KDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGR 94
Query: 82 RMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSN 141
R H + N+ AL +L R++KLVNI + DIADG P + LGL+WTIIL+FQI ++
Sbjct: 95 M--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI--- 149
Query: 142 LPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVK 201
S S D AK+ LL W Q G+
Sbjct: 150 -------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQGLRCD 181
Query: 202 DFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDV 261
+F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG+ RLLDPEDV
Sbjct: 182 NFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDV 241
Query: 262 DVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF--------- 312
DV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 242 DVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWMRHHTA 300
Query: 313 ---KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQI 365
+R F+E+++ QF E +L + ++ + YQS + ++K
Sbjct: 301 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 360
Query: 366 EHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVAL 425
H + GKL + L ++ R + ++ L G L +A+ L
Sbjct: 361 YHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL 419
Query: 426 REEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRAF--HE 465
+ ++ + + + A ++R L++ ++ Q ++R + HE
Sbjct: 420 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 479
Query: 466 -------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVL 518
Y R G+ P Q+ V+ S ++E L+Y L LL
Sbjct: 480 RLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQDLLAW 531
Query: 519 AESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQT 566
E L S + G + Q ++ + + IE ++ E Q+ T
Sbjct: 532 VEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----QLSPAT 586
Query: 567 AEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EEVISNW 615
Y G ++ K +N + A+ R+L S + + ++ EEV +W
Sbjct: 587 RGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 644
Query: 616 -DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTAMNDAG 664
DR N A +++ LE EK + + +NA R P A+
Sbjct: 645 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 704
Query: 665 NFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFA 724
+++++ C + LK+ N + + F +V++ A+ L
Sbjct: 705 SWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------------LQKLQ 742
Query: 725 TEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKE 784
+K S + ++ L+QD +D ++++ + K A + + P+
Sbjct: 743 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 802
Query: 785 MFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 836
M + +++ + K EC QL+ P + ++ S S +
Sbjct: 803 MRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSEAAVPS 853
Query: 837 IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 896
+ ++ Q + ++ +T +E Q++ VTL + L H D
Sbjct: 854 VCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-HVDMKS 892
Query: 897 LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGD- 955
L +A+QS+ + + R +K EE R L + Q L + D
Sbjct: 893 L--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLRDSQDA 943
Query: 956 ----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KLHKQWK 1009
PE+ L E+ S C L + +QG QE R + + K
Sbjct: 944 GGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRCISELK 990
Query: 1010 D--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKIIKEHR 1062
D LQ EA H L L +D E R EC + + K + EG K +
Sbjct: 991 DIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKGV---- 1040
Query: 1063 VFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMED 1122
RL E + LP P T LR+ ++ T KL +
Sbjct: 1041 -------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLGKLEQV 1077
Query: 1123 PDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRN 1172
Y + S + +E QLK + K +++++R
Sbjct: 1078 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1137
Query: 1173 GVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALVTLLSE 1223
+ T L+ L+ EV + E ++ + +A+L ++A++
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197
Query: 1224 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQQLLLH 1277
++ L G ++Y + L + ++ QEQ A+ E L + Q LL
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRGHEELR 1315
++ +++ +R +Q I + E L + +E
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317
Query: 1316 KLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESL 1375
L + L + + I TLR+ E E E Q ER L +
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER------LAEV 1365
Query: 1376 SSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKEQVKKL 1430
+ LE+ ++ ++ QAE KE E+ + QQQ +SI+E++++L
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 1431 EDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTI 1490
+ E +I+ + E I +L A E + ++ ++
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARA 1482
Query: 1491 QEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTI 1547
+E E++ +EEA+ + V + +A++ ++++ E RE + L+
Sbjct: 1483 EEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-- 1537
Query: 1548 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSS 1607
L L Q EE R+++Q+ E ++ V ++ + E L S
Sbjct: 1538 LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA---------------ELQS 1580
Query: 1608 AITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAHWQ--- 1658
+F+ ++ S +E A+ Q E+ RRA+++ A E L WQ
Sbjct: 1581 KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 1659 ------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
RL+ E + L + EA+ E + A R G+ + Q E+ Q
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELE 1695
Query: 1713 YSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDE 1772
+ L + +A++ ++ ++ EQ +++ + L + + + + + Q+ +
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 1773 LLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------VESKKG 1818
L +++ L+ E ++TSE S + R ++ A E E K
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815
Query: 1819 ELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEEASQVV 1860
+ Q + A KL ++G A ++ L + +AE+ E ++
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ERLRRLA 1870
Query: 1861 ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE 1920
E L E H + I +L Q +A++S + + L+E L Q + +
Sbjct: 1871 EDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928
Query: 1921 SAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQNLLGT 1968
+ S + KA+ L++G S EQ A QL E ER +
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EA 1986
Query: 1969 KQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDE 2027
++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++L++ +
Sbjct: 1987 EERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---- 2041
Query: 2028 LNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDL 2087
K Q +K AFA V ++ L+ T + ++ + +G+
Sbjct: 2042 ----------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089
Query: 2088 MREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFT 2146
E + + A + ++ V + E+ A ++ + A K+ + +
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 2147 SKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTR 2206
++ + K+ ++ K E T L ++E+ + LR+ L D +
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 2207 DEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELHSKVND 2260
DE + A S ++ L + EEL K + E +N+AL L + K N
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KDNT 2262
Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
+ L + E + A L + A + ++A+ +D Q EK + +
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE---KM 2316
Query: 2321 TKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL 2375
V+E+ A+ E + A ++ + +Q++ + ++ + +L
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 2376 ESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDR 2435
E A ++ E S+ QA +E ++ F + +E E + A +E
Sbjct: 2377 EMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 2436 TGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANE 2494
++ + HD + + +++++ + + + + QE + L L + + ++Q++
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE------ 2482
Query: 2495 EFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK 2553
Q L++ QALQ SE S + R + ++E+ F E + +++Q E+
Sbjct: 2483 -------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQLREEQ 2534
Query: 2554 KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTK 2613
+ + ++E L+A+ E ++R Q +EEG QE L ++ +
Sbjct: 2535 QRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ELQQLEQ 2578
Query: 2614 EKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL 2671
++ + ++ +E++ L E LQ + +A LA +E S+ K L +D L
Sbjct: 2579 QRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGRDAL 2633
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 249 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 308
Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 309 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 351
Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 352 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 400
Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 401 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457
Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 458 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 514
Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 515 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 571
Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 572 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 623
Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 624 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 681
Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 682 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 739
Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 740 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799
Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 800 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 854
Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
V + ++AQ + L L + +++ +++ L
Sbjct: 855 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 914
Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 915 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 974
Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 975 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1029
Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1030 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087
Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267
Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1268 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325
Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1381
Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
K + EV E D + +
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1419
Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
EE + +SE R + + ++I RLQ +A
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1464
Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1465 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1514
Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1515 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1569
Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
EL+ W L L L + +QK +A +E E E
Sbjct: 1630 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1670
Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1724
Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1781
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1834
Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1889
Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1890 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991
Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2050
Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2051 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2108 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165
Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2286 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342
Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2397
Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2398 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2443
Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2444 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2484
Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2485 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578
Score = 123 bits (309), Expect = 7e-27
Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)
Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 547 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 601
Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 602 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 657
Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
+ + EL + + +L G L E H A R T E
Sbjct: 658 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 696
Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 697 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 735
Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 736 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 775
Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 776 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 832
Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
++ + K S + A + A+E + ++E H + H+
Sbjct: 833 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 885
Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 886 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 945
Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 946 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1004
Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1063
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1111
Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1112 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1164
Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1165 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1224
Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1281
Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
++ L R + E L V+ E Q ++ ++ Q + +QQ++Q
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1398
Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
+R + A + S Q+ ++Q S EA + RQ AE ++
Sbjct: 1399 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1445
Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
+ + + EE+ LE E + G + ELQ L+ R + + ++A
Sbjct: 1446 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1494
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
++E+L R Q+ + + EV L ++Q L L A E LR
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
+ ++QV Q + L ++ Q E SL+++ A E
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1610
Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
+ R E+ ++++ W A E + R + + K + + +K EE
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
R + EE R +E+ ++ R + T Q R +A Q +Q +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
LEEE+ L+ ++ +T K + + ++ KV M EVLL
Sbjct: 1731 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1772
Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
+ +S EK ++ + E EA R R E+ + +L+ L +++ E+ A
Sbjct: 1773 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1825
Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
++ ++ + L + +A E + E ++ L EK+A+ + + L++
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885
Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
H+ ++ +R+ ++ LE LV+D ++++I L++ ++ + E
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1945
Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
L + ED ++ E + + + E + + LA K
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
A +EE+ + ++ + + + A LQ ++ LQ + +++ Q+
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2061
Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
Q L+ LQ+ S D L+ + +A A + E Q A++ +QV+ L
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
+EQA+ + L + + A+ Q EQT+ QK
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
Q LT EE H K+ L D++LQ +K +E A SQV++
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2228
Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
+ SV +E+++KL + E+ E++ + + R +N +E+ ++
Sbjct: 2229 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2272
Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
+ + + V ++ LA D A+ A+ + LK+ A+QE K E
Sbjct: 2273 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2331
Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
L+ QK+ E +DKE + +Q + E + FQ LE +R++++S +
Sbjct: 2332 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
E++ Q+R +E + +Q I E L ++ + L+ L I S+ +A++ L
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2448
Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
+ I + +R L E +++Q + Q+ L+ + + LSEK L
Sbjct: 2449 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2503
Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
Q I+Q + K+ L D+V+K + + Q + + E L A E
Sbjct: 2504 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
+ E E K E L +L++ + + +L + + RL+E + L+ +H
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2605
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1136 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1182
Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1183 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1235 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293
Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
L E E+L+E +A + E + +A + K + + R
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1525
Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705
Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1706 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1757
Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1815
Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 1996 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2044
Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
+ + E L ++S EE + + A
Sbjct: 2105 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2139
Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
A +A+ QA ++ DA A Q + L
Sbjct: 2140 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2248
Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2249 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2308 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2363
Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2364 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2406
Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2456
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2511 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2566
Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2623
Query: 6406 ALLP 6409
LP
Sbjct: 2624 KTLP 2627
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324
Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1384 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1441 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1488
Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1489 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1542
Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
++A+ A L EVE AE T L+ L
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1599
Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
H +V + E E E+ + R + S+ Q
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659
Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
A Q AER K +E E LE G Q+ + +I
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1836
Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1891
Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
E +K++AE A + R+L K +L E+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2072 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
L L EE Q + L+ + + S VEE LF
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2231
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
++ EE+ K K +NR +I L D
Sbjct: 2232 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2261
Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321
Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2322 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2488 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2522
Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633
Score = 104 bits (259), Expect = 4e-21
Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
L+TI+ + + E + E++L Q TL A K + Q T D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
+ AQ + + L E +++ R+ Q + W + + Q D+ L R
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
Q++++R + +L D + A + + Q + ++L Q Q L
Sbjct: 1208 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1255
Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
EEI+ ++ + A Q + +K EL+L + + V KK + + S
Sbjct: 1256 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310
Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
+ I E V+ T + E+ L Q++ ++ ++ EE L Q+ + + +
Sbjct: 1311 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1363
Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
VE LEK LA + A++ A K+L +QE R+ A D + QK+ +
Sbjct: 1364 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
E L + E Q E+ ++E+ I+ ++Q+ T + EL ++
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
+R +E E + Q AE L++ D +Q + + S ++A KQ L++
Sbjct: 1480 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
L ++A+R + + + +Q AL AQ ++L +R + +EKT
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1590
Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
L Q ++H RE ++ + + A+ L+ +Q NE L
Sbjct: 1591 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1696
Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
Q + + EL A+ + +Q E L LQR
Sbjct: 1697 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
E L +L + + V++A K +E+ ++ +E
Sbjct: 1746 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
EL + R+ + + + L+ +D R + +++A +GEA + + +
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857
Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
+K L + + QR L E + E+ QL + S E Q
Sbjct: 1858 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909
Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
+ E+TL +++ + A + + L R+ + ED + E
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969
Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
AR + + + E + E E R+ +S+ + E +R +L+ + R+KA++
Sbjct: 1970 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
L + QE R++Q+ QE Q K L + + H+ A
Sbjct: 2021 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2057
Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
+ + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A + VE AE
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2115
Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
+S E Q + E+L +++ EQ+ A R ++
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2153
Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2202
Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
N E++ L+ +A++ + + + S + + R A+++ IL D
Sbjct: 2203 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
D F +++ E + Q+ ++ S A L L E +L QQ++
Sbjct: 2260 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2309
Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
+ ++ + +Q+ A E L Q+ Q++ +QE D+E +
Sbjct: 2310 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2354
Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
Q+ Q T E +E+ A+ E L++ + E A Q K AEE
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
EK + +EL+ Q +V L + Q Q + E+ + EL R+ +KL ++
Sbjct: 2415 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467
Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
L +LK++ VQ +++L E S L E D+ +Q +F+EQ +L +
Sbjct: 2468 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2573
Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
QL +Q + LL EE++ + +L+ + E+ L + V ++ + + GR+
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2632
Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2633 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2673
Score = 100 bits (248), Expect = 8e-20
Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)
Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 392 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 448
Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 449 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 501
Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 502 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 558
Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 559 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 613
Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 614 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 671
Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 672 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 728
Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 729 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788
Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
+++ +L R G G E +L SH +L + +
Sbjct: 789 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848
Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 849 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 906
Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 907 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 962
Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 963 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1018
Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1072
Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
K++ ++++ L A EV + + H E W++
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1187
Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++ S
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307
Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
G S +I+EY L S+ + Q + ++ ++ + + + +
Sbjct: 1308 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
+EV +L+K Q +L ++ + + KE + +Q +V +E +
Sbjct: 1363 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1411
Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
+ L+ L+ Q + E+ A+ Q ++ ++ E R+ L + E+Q+
Sbjct: 1412 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
LQ++ E Q + +E+A++L + Q S+ R +L+S+ A + +E
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530
Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
K L + Q + L+ + + + L++ EA L K
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1581
Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
+ EK Q++ + + E QQQ ++ R + + E
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1629
Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
L +W + + + + + E+E+Q E + GKA+
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1680
Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
E V Q EL Q+L+++ + + A++ + ++L+RL E ++
Sbjct: 1681 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1724
Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
G++Q +L ++ + L+ +A ++L+ EL AE + LL S E
Sbjct: 1725 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
+ + + LE+ ++ + R + +L E+ +
Sbjct: 1777 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
+ E L E +T + KE + ++++ E+ R +EE A+ + ++E
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
R + R + L+ L Q + +EEEI +L+ S ++ G +
Sbjct: 1895 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1947
Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
+ + DT + K+ LE + + + RE ER K L E EA R RK
Sbjct: 1948 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
+ +E+LK R+ E + L LA+E + K + E
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2050
Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
K + A K + LQQT+ + + +R + EA E ++ ++ + + QS
Sbjct: 2051 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
Q + S E + + + +++ K Q + R + +
Sbjct: 2108 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165
Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
++ HK E+ A E L L+++ + DH + L + LQ K
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2213
Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
A + A R +E EL + + L + +A + A + D + + + AE
Sbjct: 2214 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272
Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
+KQV +E AR S+ A ++ A++ ++ + +K+++ + Q
Sbjct: 2273 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2319
Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
+E LK+E + LQ + Q RR E + +AQ + + + F + L++++
Sbjct: 2320 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
A + +V ++++ + E K+ + ++ +L Q +Q E +Q
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2437
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
R + HD + E +A + E + EA K L L +E + ++
Sbjct: 2438 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2485
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
Q+ + ++ L +K+ + ++ +EQ +LE L Q V ++L Q R Q+ M
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2541
Query: 4358 EWAEEQQPNIA 4368
E +E+Q +A
Sbjct: 2542 E--QERQRLVA 2550
Score = 98.6 bits (244), Expect = 2e-19
Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)
Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
H++ L K+ A E + E Q Q + LG + + L +AE L E S
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1058
Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
+ L L+ SLS I + +T+ + +++ + L+ A+A
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1117
Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
+ + L+ + + L+ + Q+ + A D+L G EV ER+Q G + E +
Sbjct: 1118 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
++++ +LL+ + + +TD +++ + L ++LR + + D L +
Sbjct: 1177 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1221
Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
WL+D ++ Q+ + P D + R ++ + L+ E +
Sbjct: 1222 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1262
Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
V + A I IKD E L + ++ + + S
Sbjct: 1263 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1299
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
KK V++ ES + +++D+ E + + L +E E +
Sbjct: 1300 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1353
Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
+ E ++ ++ L + L E ++ K +A R +EL ++ + E+ + E D
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1411
Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
Q + + ++L+ ++ +E + A++ Q E A+
Sbjct: 1412 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1446
Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
++++ ++ +L++ + + L +L + AE E L R +
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
+K +A +L S+ +A + + EK ++Q +E L A+ A + ++ +A
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1555
Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
++ + + ++ Q +A Q + +A + Q+ S+QE+ + + EE + +
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
Q + ++A ++ EL ++ ++ +L L E+ ++ + KQ E + E
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1674
Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
+ + + RE ++ ++ + L+E G Q Q L + Q L+R+ E
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1722
Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
+ Q+ + LEE L + R A A + + LE L+++ + E E
Sbjct: 1723 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1765
Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
V L + + E+ RS++++ ++ ++ + +E+ + A+ D
Sbjct: 1766 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824
Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
++ + E + + ++ + + + LKEK + L+ + + R L
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
A+ + E+ + + + EL+ Q + +++ + EEI+ + A +
Sbjct: 1885 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
+ S E+ R + + +A Q++L+ +E R R+ + + E
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 2001
Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
+ A+ E+ + +A R + ++S Q Q E ++ E+ + V Q
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
EQ L+Q T Q+ ++L+ + E +E +A +AE + Q+ E
Sbjct: 2062 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
R + + + L +A + + Q Q R Q+ +A++
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2167
Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
K F Q + + + Q++ + E H+ N++ E+ + ++A
Sbjct: 2168 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2214
Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
+ T A Q E L ++++QM++ LSK + + E+ NR
Sbjct: 2215 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2255
Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
L K Q+ LQ E++ + RL AQ+ R+ QL+ + LA
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2304
Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
EK+ +KE ++V ++ LK EA
Sbjct: 2305 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2329
Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
L ++Q+KE+ Q + + E + Q + E Q+ L++ + + + R K
Sbjct: 2330 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2387
Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
+ V + S E + +Q E+ +K L + +L +E ++
Sbjct: 2388 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2429
Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
L++T+E++ ++H +L + +L+ +Q+ AK KSE++ + QE
Sbjct: 2430 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2483
Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
L QE + L Q + E D+ + ++ ++ Q + V ++
Sbjct: 2484 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2529
Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
+ + + R + + Q+ Q + E R + + +R +++ QQ+++ + EE
Sbjct: 2530 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586
Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
++ + N+ +E QL +++ H A+ +EV
Sbjct: 2587 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2615
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1232
Query: 639 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1292
Query: 690 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 747 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1409
Query: 805 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
+ + + L++L +Q + S +I E I V+
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 843 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 884 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 936 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 993 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1703 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1751
Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1802
Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
+RL+ L E + + D + + + + L L+ +
Sbjct: 1803 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1842
Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1843 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1889
Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1890 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1943 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2047
Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2104
Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2282 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2400
Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2401 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2506
Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2561
Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2562 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612
Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2613 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2664
Query: 2086 DLMREYQNLKSAVSKVLENA 2105
E Q L + V E A
Sbjct: 2665 S-AEELQRLAQGHTTVDELA 2683
Score = 84.0 bits (206), Expect = 6e-15
Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)
Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
G+ E++R ++E+LK ++ +R E+ L +E + +A+ + E
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1125
Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
E K L + +AQ ++ Q T + ++ +E GE L + V+ +++
Sbjct: 1126 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180
Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
+ QL +Q + + LE + Y + WL R + +
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
+ + +QL +A++EEI +++ Q I D+ +A+L+
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300
Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
++V + YS + + + + + L++ + +Q +A
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360
Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
L+ V+ LE Q ++A+A ++ K + ++ + S++
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
+ ++Q +E I+ K QA+ + EEI+ ++ +L + A+ +LQ ++
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480
Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
R E E A+ + QV+D + + +QA V E +++ + E+ K+
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1534
Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ L + L L R+ +++R R + + E E + S AE
Sbjct: 1535 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1588
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
TA +L +LQE A+ L+++ ++ + + E +E+ +RW +
Sbjct: 1589 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1639
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ ++ ++Q ++ ++ Q+ ++ E AE + +A +Q+ ++
Sbjct: 1640 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+E A+Q L R + G +RQ++++ L+ Q + + L
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
K +E L + +A + + K FRE L ++ ++ + A+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1814
Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
+ + + A+ ++ EK +G+ L++ + L++ + RL+ L
Sbjct: 1815 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
E R+ +E A H +ADI SEL Q ++ L Q + E
Sbjct: 1870 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1924
Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
+L L+ + + E++ + NA E L KE
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1964
Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
A L + L+ E + R + +V LA EE + Q +A L+EV L V+E
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2022
Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
+ +E + + L L + + Q E++ ++ Q+ + +
Sbjct: 2023 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
QL + ++ + + E + AE + + A L+ S + + A
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
L A ++A + Q+ Q L+ +A E ++++ Q + +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
T+ ++L + L+R+KAE + ++EE+ +++ EE+ RI AL
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
++K+ + + + ++ E + L QEA R RQ ++ Q +
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
Q Q A + L+ +EL Q L D E + L + F
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
+ + + E L VA + + +ED ++ E +++ R A +V L+Q
Sbjct: 2375 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
Q HD ++ RE + EL + EK E LL+ S + E+ L E +AL
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
+S +S ++ +E++ ++LE+ D +KA R ++ + + + Q+++++
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2548
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
+ + + +A E + + Q++L ++ + ELL L+L ++Q
Sbjct: 2549 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
+ + ++ Q A T
Sbjct: 2605 HRAALAHSEEVTASQVAATKT 2625
Score = 72.8 bits (177), Expect = 1e-11
Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)
Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
Q+ + T L AQ A++ H+ V+++ +L W Q L R ++++ S S+ +
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 914
Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
++ E R Q L S YQ L D G D + G C
Sbjct: 915 RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 961
Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
++ + L LE + +R Q SE D+ L++ + R T + +P +
Sbjct: 962 ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 1013
Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
E R+ E K EV+ + + + ++L L + A TLRSEL
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1070
Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
L + V+ L + ++KL + IS V+ E V++ E+ +K + A
Sbjct: 1071 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122
Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
L+ K + +Q T D + + + +DVE +R +
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1177
Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
E++ + + WQ + + + LE L Y + L W + +R +Q +
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1236
Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
L D Q + + ++ ++ +E+IE++G
Sbjct: 1237 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1262
Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
V + + K ++ +++ + L + ++ +GS +Q VD
Sbjct: 1263 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1318
Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
L+ +L ++T+Q +K ++ETL +E + EE E+L
Sbjct: 1319 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1363
Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
+A L+ + + ++ A Q E EL + + + +E A D +
Sbjct: 1364 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1414
Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
++++ L L + E + Q A A A + +L + + + + L + T Q G
Sbjct: 1415 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1471
Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
+ E L+AL A EAE + QE E L+ Q+ S +
Sbjct: 1472 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
EL R+ + + Q + + Q E +L+ ++ Q LE +
Sbjct: 1516 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
E +Q+++ E + + L+++ A +AE ++QQ + +R LE+
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
Q+ + L+L ++ Q A++++ + + R+ + E A + R E+
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1689
Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
+ + + Q R ++ E + LR + E G+Q
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1731
Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
L+ ELA +Q + +A+ + +E + +LA + + E A + E+ R+ +K Q L
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
EL E R + L + + + + + A+ ++ + E L +
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1850
Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
+ E + +++ RL E F + E E DI EE + +L+
Sbjct: 1851 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1899
Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
K E+ + ++ Q +Q+ E + KAS E A+ E+E +LG++ + L
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
+L AAR ++L + A +++ K++++ E E A+
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 2011
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
E ++ K+ E + L+ E+ S A L L + A ++QQ + L +
Sbjct: 2012 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
+ ++ + R + E R ++ E+ +ER AA E L
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2117
Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
K+ Q Q + E + K+ + A +L+Q ++ +
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2165
Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
+ + K F Q R++ + ++ LT + LQL +H + ++++LKA E
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2219
Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
+ +++E+ + Q E+L + ++A A+I + D +R+ QE ++++ ++
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
RL + E L++ +L + + A L ++ + + L L + L
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2338
Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
E++ R + R LE+ R L E + + LR A +S
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2393
Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
+ E ++ K ++ ++ +TE + K L+ + +I
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453
Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
++R + KL++E + L L S E QT +Q + L +E + Q Q F
Sbjct: 2454 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2495
Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
S+ +S+ E+E +L++L + +L+ ++ ++ Q+ R+ ++ S+
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
+A+ R Q+ L Q+ + + LL E L++ L + H
Sbjct: 2556 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Score = 66.6 bits (161), Expect = 1e-09
Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)
Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1142 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194
Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1195 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1254
Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1255 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314
Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1361
Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1416
Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1597 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1651 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1704
Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1705 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
E + EM++ L + E K + + E ++ + A+ L
Sbjct: 1754 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1809
Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
E+++ + EE+ R + V + RL + E L ++E E E
Sbjct: 1810 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1867
Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
L++ R + Q +++ LAQ ++ S + + L +
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1927
Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
L E A + E E G + + + LR S + + LE+ RQ A ++ R
Sbjct: 1928 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1981
Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
+ ++ E ++ E K ++ + + ++ +RL + ++E
Sbjct: 1982 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2035
Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
L + + E A A+ KE ++Q LQ+ Q L EE E+
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
R++ + Q+++ + L+++ + + + + +A+ + +R Q
Sbjct: 2096 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
+ + + + +E+ + + L Q + L L LE D +KN + L
Sbjct: 2155 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
AE + +Q Q++ EL ++++ L + ++
Sbjct: 2214 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 979 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1026
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1027 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1084
Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1143
Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1185
Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1186 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1241
Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1294
Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1534 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1588
Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1589 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1646
Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1707 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1817
Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1818 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1867
Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1868 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1912
Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1913 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1945
Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2063
Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2064 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2106
Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2161
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2162 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2214
Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2275 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2326
Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2367
Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2368 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2421
Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2422 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2463
Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2464 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2505
Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2506 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2556
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
R QH + V++ +E L QQL++ LA +
Sbjct: 2557 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2591
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2592 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2645
Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2702
Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
E+L + A QRQ+ T L L+ Q
Sbjct: 2703 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2733
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 267 bits (683), Expect = 3e-70
Identities = 593/2877 (20%), Positives = 1111/2877 (38%), Gaps = 509/2877 (17%)
Query: 23 DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP E+GR
Sbjct: 42 DERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 99
Query: 83 MKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNL 142
R H + N+ AL +L R++KLVNI + DIADG P + LGL+WTIIL+FQI ++
Sbjct: 100 --RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI---- 153
Query: 143 PQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKD 202
S S D AK+ LL W Q G+ +
Sbjct: 154 ------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQGLRCDN 186
Query: 203 FGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDVD 262
F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG+ RLLDPEDVD
Sbjct: 187 FTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVD 246
Query: 263 VDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF---------- 312
V +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 247 VPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWMRHHTAA 305
Query: 313 --KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIE 366
+R F+E+++ QF E +L + ++ + YQS + ++K
Sbjct: 306 FEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGY 365
Query: 367 HLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALR 426
H + GKL + L ++ R + ++ L G L +A+ L+
Sbjct: 366 HPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 424
Query: 427 EEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRAF--HE- 465
++ + + + A ++R L++ ++ Q ++R + HE
Sbjct: 425 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER 484
Query: 466 ------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA 519
Y R G+ P Q+ V+ S ++E L+Y L LL
Sbjct: 485 LVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQDLLAWV 536
Query: 520 ESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTA 567
E L S + G + Q ++ + + IE ++ E Q+ T
Sbjct: 537 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----QLSPATR 591
Query: 568 EMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EEVISNW- 615
Y G ++ K +N + A+ R+L S + + ++ EEV +W
Sbjct: 592 GAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWS 649
Query: 616 DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTAMNDAGN 665
DR N A +++ LE EK + + +NA R P A+ +
Sbjct: 650 DRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWS 709
Query: 666 FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFAT 725
++++ C + LK+ N + + F +V++ A+ L
Sbjct: 710 WMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------------LQKLQE 747
Query: 726 EAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEM 785
+K S + ++ L+QD +D ++++ + K A + + P+ M
Sbjct: 748 ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 807
Query: 786 FATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEI 837
+ +++ + K EC QL+ P + ++ S S + +
Sbjct: 808 RGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSEAAVPSV 858
Query: 838 ITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRL 897
++ Q + ++ +T +E Q++ VTL + L H D L
Sbjct: 859 CFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-HVDMKSL 897
Query: 898 QRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGD-- 955
+A+QS+ + + R +K EE R L + Q L + D
Sbjct: 898 --------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLRDSQDAG 948
Query: 956 ---PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KLHKQWKD 1010
PE+ L E+ S C L + +QG QE R + + KD
Sbjct: 949 GFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRCISELKD 995
Query: 1011 --LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKIIKEHRV 1063
LQ EA H L L +D E R EC + + K + EG K +
Sbjct: 996 IRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKGV----- 1044
Query: 1064 FFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDP 1123
RL E + LP P T LR+ ++ T KL +
Sbjct: 1045 ------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLGKLEQVR 1082
Query: 1124 DKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG 1173
Y + S + +E QLK + K +++++R
Sbjct: 1083 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1142
Query: 1174 VTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALVTLLSEV 1224
+ T L+ L+ EV + E ++ + +A+L ++A++
Sbjct: 1143 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1202
Query: 1225 EKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQQLLLHH 1278
++ L G ++Y + L + ++ QEQ A+ E L + Q LL
Sbjct: 1203 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI 1262
Query: 1279 QQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRGHEELRK 1316
++ +++ +R +Q I + E L + +E
Sbjct: 1263 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1322
Query: 1317 LESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLS 1376
L + L + + I TLR+ E E E Q ER L +
Sbjct: 1323 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER------LAEVE 1370
Query: 1377 SELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKEQVKKLE 1431
+ LE+ ++ ++ QAE KE E+ + QQQ +SI+E++++L
Sbjct: 1371 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1430
Query: 1432 DTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQ 1491
+ E +I+ + E I +L A E + ++ ++ +
Sbjct: 1431 QSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAE 1487
Query: 1492 EIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTIL 1548
E E++ +EEA+ + V + +A++ ++++ E RE + L+ L
Sbjct: 1488 EAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA--L 1542
Query: 1549 GHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSA 1608
L Q EE R+++Q+ E ++ V ++ + E L S
Sbjct: 1543 EELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA---------------ELQSK 1585
Query: 1609 ITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAHWQ---- 1658
+F+ ++ S +E A+ Q E+ RRA+++ A E L WQ
Sbjct: 1586 RASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1643
Query: 1659 -----RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFY 1713
RL+ E + L + EA+ E + A R G+ + Q E+ Q
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEK 1700
Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
+ L + +A++ ++ ++ EQ +++ + L + + + + + Q+ +
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1760
Query: 1774 LLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------VESKKGE 1819
L +++ L+ E ++TSE S + R ++ A E E K +
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820
Query: 1820 LQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEEASQVVE 1861
Q + A KL ++G A ++ L + +AE+ E ++ E
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ERLRRLAE 1875
Query: 1862 RRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALES 1921
L E H + I +L Q +A++S + + L+E L Q + + +
Sbjct: 1876 DEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1933
Query: 1922 AAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQNLLGTK 1969
S + KA+ L++G S EQ A QL E ER + +
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAE 1991
Query: 1970 QSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDEL 2028
+ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++L++ +
Sbjct: 1992 ERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE----- 2045
Query: 2029 NSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM 2088
K Q +K AFA V ++ L+ T + ++ + +G+
Sbjct: 2046 ---------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Query: 2089 REYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTS 2147
E + + A + ++ V + E+ A ++ + A K+ + + +
Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2154
Query: 2148 KGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRD 2207
+ + K+ ++ K E T L ++E+ + LR+ L D + D
Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 2208 EIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELHSKVNDL 2261
E + A S ++ L + EEL K + E +N+AL L + K N
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KDNTQ 2267
Query: 2262 KELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFT 2321
+ L + E + A L + A + ++A+ +D Q EK + +
Sbjct: 2268 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE---KMQ 2321
Query: 2322 KVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
V+E+ A+ E + A ++ + +Q++ + ++ + +LE
Sbjct: 2322 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381
Query: 2377 SLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRT 2436
A ++ E S+ QA +E ++ F + +E E + A +E
Sbjct: 2382 MSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTLV 2435
Query: 2437 GDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEE 2495
++ + HD + + +++++ + + + + QE + L L + + ++Q++
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE------- 2486
Query: 2496 FQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKK 2554
Q L++ QALQ SE S + R + ++E+ F E + +++Q E++
Sbjct: 2487 ------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQLREEQQ 2539
Query: 2555 NEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKE 2614
+ ++E L+A+ E ++R Q +EEG QE L ++ ++
Sbjct: 2540 RQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ELQQLEQQ 2583
Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL 2671
+ + ++ +E++ L E LQ + +A LA +E S+ K L +D L
Sbjct: 2584 RRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGRDAL 2637
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 253 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 312
Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 313 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 355
Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 356 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 404
Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 405 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 461
Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 462 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 518
Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 519 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 575
Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 576 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 627
Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 628 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 685
Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 686 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 743
Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 744 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 803
Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 804 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 858
Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
V + ++AQ + L L + +++ +++ L
Sbjct: 859 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 918
Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 919 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 978
Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 979 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1033
Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1034 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1091
Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151
Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1152 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211
Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1212 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1271
Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1272 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1329
Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1330 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1385
Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
K + EV E D + +
Sbjct: 1386 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1423
Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
EE + +SE R + + ++I RLQ +A
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1468
Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1469 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1518
Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1519 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1573
Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633
Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
EL+ W L L L + +QK +A +E E E
Sbjct: 1634 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1674
Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1728
Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1729 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1785
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1786 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1838
Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1893
Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1894 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1935
Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1995
Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1996 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2054
Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2055 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2112 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2169
Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2229
Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289
Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2290 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2346
Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2401
Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2402 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2447
Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2448 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2488
Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2489 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2582
Score = 123 bits (309), Expect = 7e-27
Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)
Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 551 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 605
Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 606 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 661
Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
+ + EL + + +L G L E H A R T E
Sbjct: 662 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 700
Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 701 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 739
Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 740 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 779
Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 780 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 836
Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
++ + K S + A + A+E + ++E H + H+
Sbjct: 837 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 889
Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 890 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 949
Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 950 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1008
Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 1009 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1067
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1068 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1115
Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1116 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1168
Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1169 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1228
Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1229 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1285
Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1286 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1345
Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
++ L R + E L V+ E Q ++ ++ Q + +QQ++Q
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1402
Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
+R + A + S Q+ ++Q S EA + RQ AE ++
Sbjct: 1403 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1449
Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
+ + + EE+ LE E + G + ELQ L+ R + + ++A
Sbjct: 1450 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1498
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
++E+L R Q+ + + EV L ++Q L L A E LR
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1558
Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
+ ++QV Q + L ++ Q E SL+++ A E
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1614
Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
+ R E+ ++++ W A E + R + + K + + +K EE
Sbjct: 1615 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674
Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
R + EE R +E+ ++ R + T Q R +A Q +Q +
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734
Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
LEEE+ L+ ++ +T K + + ++ KV M EVLL
Sbjct: 1735 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1776
Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
+ +S EK ++ + E EA R R E+ + +L+ L +++ E+ A
Sbjct: 1777 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1829
Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
++ ++ + L + +A E + E ++ L EK+A+ + + L++
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1889
Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
H+ ++ +R+ ++ LE LV+D ++++I L++ ++ + E
Sbjct: 1890 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1949
Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
L + ED ++ E + + + E + + LA K
Sbjct: 1950 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2009
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
A +EE+ + ++ + + + A LQ ++ LQ + +++ Q+
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2065
Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
Q L+ LQ+ S D L+ + +A A + E Q A++ +QV+ L
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
+EQA+ + L + + A+ Q EQT+ QK
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2185
Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
Q LT EE H K+ L D++LQ +K +E A SQV++
Sbjct: 2186 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2232
Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
+ SV +E+++KL + E+ E++ + + R +N +E+ ++
Sbjct: 2233 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2276
Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
+ + + V ++ LA D A+ A+ + LK+ A+QE K E
Sbjct: 2277 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2335
Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
L+ QK+ E +DKE + +Q + E + FQ LE +R++++S +
Sbjct: 2336 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394
Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
E++ Q+R +E + +Q I E L ++ + L+ L I S+ +A++ L
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2452
Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
+ I + +R L E +++Q + Q+ L+ + + LSEK L
Sbjct: 2453 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2507
Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
Q I+Q + K+ L D+V+K + + Q + + E L A E
Sbjct: 2508 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560
Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
+ E E K E L +L++ + + +L + + RL+E + L+ +H
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2609
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1140 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1186
Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1187 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238
Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1239 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1297
Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1298 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1353
Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
L E E+L+E +A + E + +A + K + + R
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1413
Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473
Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1529
Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589
Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1709
Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1710 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1761
Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1819
Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1820 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879
Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939
Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999
Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 2000 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2048
Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2108
Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
+ + E L ++S EE + + A
Sbjct: 2109 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2143
Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
A +A+ QA ++ DA A Q + L
Sbjct: 2144 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201
Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2252
Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2253 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2311
Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2312 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2367
Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2368 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2410
Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2411 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2460
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2514
Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2515 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2570
Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2627
Query: 6406 ALLP 6409
LP
Sbjct: 2628 KTLP 2631
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1148
Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1149 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268
Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1269 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1328
Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1329 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1387
Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1388 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1444
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1445 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1492
Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1493 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1546
Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
++A+ A L EVE AE T L+ L
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1603
Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
H +V + E E E+ + R + S+ Q
Sbjct: 1604 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1663
Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
A Q AER K +E E LE G Q+ + +I
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1723
Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1724 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1784 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1840
Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1895
Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955
Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
E +K++AE A + R+L K +L E+
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075
Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2076 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189
Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
L L EE Q + L+ + + S VEE LF
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2235
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
++ EE+ K K +NR +I L D
Sbjct: 2236 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2265
Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2266 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2325
Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2326 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2431
Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491
Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2492 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2526
Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2586
Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2587 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2637
Score = 104 bits (259), Expect = 4e-21
Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
L+TI+ + + E + E++L Q TL A K + Q T D
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151
Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
+ AQ + + L E +++ R+ Q + W + + Q D+ L R
Sbjct: 1152 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211
Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
Q++++R + +L D + A + + Q + ++L Q Q L
Sbjct: 1212 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1259
Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
EEI+ ++ + A Q + +K EL+L + + V KK + + S
Sbjct: 1260 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1314
Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
+ I E V+ T + E+ L Q++ ++ ++ EE L Q+ + + +
Sbjct: 1315 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1367
Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
VE LEK LA + A++ A K+L +QE R+ A D + QK+ +
Sbjct: 1368 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
E L + E Q E+ ++E+ I+ ++Q+ T + EL ++
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483
Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
+R +E E + Q AE L++ D +Q + + S ++A KQ L++
Sbjct: 1484 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1541
Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
L ++A+R + + + +Q AL AQ ++L +R + +EKT
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1594
Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
L Q ++H RE ++ + + A+ L+ +Q NE L
Sbjct: 1595 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1700
Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
Q + + EL A+ + +Q E L LQR
Sbjct: 1701 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1749
Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
E L +L + + V++A K +E+ ++ +E
Sbjct: 1750 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1801
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
EL + R+ + + + L+ +D R + +++A +GEA + + +
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1861
Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
+K L + + QR L E + E+ QL + S E Q
Sbjct: 1862 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1913
Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
+ E+TL +++ + A + + L R+ + ED + E
Sbjct: 1914 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1973
Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
AR + + + E + E E R+ +S+ + E +R +L+ + R+KA++
Sbjct: 1974 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2024
Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
L + QE R++Q+ QE Q K L + + H+ A
Sbjct: 2025 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2061
Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
+ + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A + VE AE
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2119
Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
+S E Q + E+L +++ EQ+ A R ++
Sbjct: 2120 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2157
Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2206
Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
N E++ L+ +A++ + + + S + + R A+++ IL D
Sbjct: 2207 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2263
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
D F +++ E + Q+ ++ S A L L E +L QQ++
Sbjct: 2264 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2313
Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
+ ++ + +Q+ A E L Q+ Q++ +QE D+E +
Sbjct: 2314 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2358
Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
Q+ Q T E +E+ A+ E L++ + E A Q K AEE
Sbjct: 2359 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418
Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
EK + +EL+ Q +V L + Q Q + E+ + EL R+ +KL ++
Sbjct: 2419 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2471
Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
L +LK++ VQ +++L E S L E D+ +Q +F+EQ +L +
Sbjct: 2472 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2526
Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2577
Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
QL +Q + LL EE++ + +L+ + E+ L + V ++ + + GR+
Sbjct: 2578 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2636
Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2637 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2677
Score = 100 bits (248), Expect = 8e-20
Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)
Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 396 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 452
Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 453 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 505
Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 506 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 562
Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 563 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 617
Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 618 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 675
Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 676 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 732
Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 733 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 792
Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
+++ +L R G G E +L SH +L + +
Sbjct: 793 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 852
Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 853 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 910
Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 911 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 966
Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 967 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1022
Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1023 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1076
Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1077 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1136
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
K++ ++++ L A EV + + H E W++
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1191
Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1251
Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++ S
Sbjct: 1252 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1311
Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
G S +I+EY L S+ + Q + ++ ++ + + + +
Sbjct: 1312 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366
Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
+EV +L+K Q +L ++ + + KE + +Q +V +E +
Sbjct: 1367 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1415
Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
+ L+ L+ Q + E+ A+ Q ++ ++ E R+ L + E+Q+
Sbjct: 1416 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474
Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
LQ++ E Q + +E+A++L + Q S+ R +L+S+ A + +E
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1534
Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
K L + Q + L+ + + + L++ EA L K
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1585
Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
+ EK Q++ + + E QQQ ++ R + + E
Sbjct: 1586 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1633
Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
L +W + + + + + E+E+Q E + GKA+
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1684
Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
E V Q EL Q+L+++ + + A++ + ++L+RL E ++
Sbjct: 1685 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1728
Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
G++Q +L ++ + L+ +A ++L+ EL AE + LL S E
Sbjct: 1729 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780
Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
+ + + LE+ ++ + R + +L E+ +
Sbjct: 1781 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
+ E L E +T + KE + ++++ E+ R +EE A+ + ++E
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898
Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
R + R + L+ L Q + +EEEI +L+ S ++ G +
Sbjct: 1899 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1951
Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
+ + DT + K+ LE + + + RE ER K L E EA R RK
Sbjct: 1952 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2009
Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
+ +E+LK R+ E + L LA+E + K + E
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2054
Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
K + A K + LQQT+ + + +R + EA E ++ ++ + + QS
Sbjct: 2055 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111
Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
Q + S E + + + +++ K Q + R + +
Sbjct: 2112 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2169
Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
++ HK E+ A E L L+++ + DH + L + LQ K
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2217
Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
A + A R +E EL + + L + +A + A + D + + + AE
Sbjct: 2218 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2276
Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
+KQV +E AR S+ A ++ A++ ++ + +K+++ + Q
Sbjct: 2277 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2323
Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
+E LK+E + LQ + Q RR E + +AQ + + + F + L++++
Sbjct: 2324 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382
Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
A + +V ++++ + E K+ + ++ +L Q +Q E +Q
Sbjct: 2383 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2441
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
R + HD + E +A + E + EA K L L +E + ++
Sbjct: 2442 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2489
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
Q+ + ++ L +K+ + ++ +EQ +LE L Q V ++L Q R Q+ M
Sbjct: 2490 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2545
Query: 4358 EWAEEQQPNIA 4368
E +E+Q +A
Sbjct: 2546 E--QERQRLVA 2554
Score = 98.6 bits (244), Expect = 2e-19
Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)
Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
H++ L K+ A E + E Q Q + LG + + L +AE L E S
Sbjct: 1009 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1062
Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
+ L L+ SLS I + +T+ + +++ + L+ A+A
Sbjct: 1063 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1121
Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
+ + L+ + + L+ + Q+ + A D+L G EV ER+Q G + E +
Sbjct: 1122 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1180
Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
++++ +LL+ + + +TD +++ + L ++LR + + D L +
Sbjct: 1181 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1225
Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
WL+D ++ Q+ + P D + R ++ + L+ E +
Sbjct: 1226 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1266
Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
V + A I IKD E L + ++ + + S
Sbjct: 1267 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1303
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
KK V++ ES + +++D+ E + + L +E E +
Sbjct: 1304 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1357
Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
+ E ++ ++ L + L E ++ K +A R +EL ++ + E+ + E D
Sbjct: 1358 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1415
Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
Q + + ++L+ ++ +E + A++ Q E A+
Sbjct: 1416 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1450
Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
++++ ++ +L++ + + L +L + AE E L R +
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510
Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
+K +A +L S+ +A + + EK ++Q +E L A+ A + ++ +A
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1559
Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
++ + + ++ Q +A Q + +A + Q+ S+QE+ + + EE + +
Sbjct: 1560 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
Q + ++A ++ EL ++ ++ +L L E+ ++ + KQ E + E
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1678
Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
+ + + RE ++ ++ + L+E G Q Q L + Q L+R+ E
Sbjct: 1679 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1726
Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
+ Q+ + LEE L + R A A + + LE L+++ + E E
Sbjct: 1727 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1769
Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
V L + + E+ RS++++ ++ ++ + +E+ + A+ D
Sbjct: 1770 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1828
Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
++ + E + + ++ + + + LKEK + L+ + + R L
Sbjct: 1829 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
A+ + E+ + + + EL+ Q + +++ + EEI+ + A +
Sbjct: 1889 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1947
Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
+ S E+ R + + +A Q++L+ +E R R+ + + E
Sbjct: 1948 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 2005
Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
+ A+ E+ + +A R + ++S Q Q E ++ E+ + V Q
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
EQ L+Q T Q+ ++L+ + E +E +A +AE + Q+ E
Sbjct: 2066 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2117
Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
R + + + L +A + + Q Q R Q+ +A++
Sbjct: 2118 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2171
Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
K F Q + + + Q++ + E H+ N++ E+ + ++A
Sbjct: 2172 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2218
Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
+ T A Q E L ++++QM++ LSK + + E+ NR
Sbjct: 2219 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2259
Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
L K Q+ LQ E++ + RL AQ+ R+ QL+ + LA
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2308
Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
EK+ +KE ++V ++ LK EA
Sbjct: 2309 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2333
Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
L ++Q+KE+ Q + + E + Q + E Q+ L++ + + + R K
Sbjct: 2334 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2391
Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
+ V + S E + +Q E+ +K L + +L +E ++
Sbjct: 2392 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2433
Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
L++T+E++ ++H +L + +L+ +Q+ AK KSE++ + QE
Sbjct: 2434 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2487
Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
L QE + L Q + E D+ + ++ ++ Q + V ++
Sbjct: 2488 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2533
Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
+ + + R + + Q+ Q + E R + + +R +++ QQ+++ + EE
Sbjct: 2534 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2590
Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
++ + N+ +E QL +++ H A+ +EV
Sbjct: 2591 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2619
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1177 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1236
Query: 639 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1237 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1296
Query: 690 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1297 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1356
Query: 747 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1413
Query: 805 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
+ + + L++L +Q + S +I E I V+
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473
Query: 843 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1533
Query: 884 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592
Query: 936 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652
Query: 993 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1706
Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1707 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1755
Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1806
Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
+RL+ L E + + D + + + + L L+ +
Sbjct: 1807 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1846
Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1847 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1893
Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1894 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1947 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1997
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2051
Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2052 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2108
Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2109 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168
Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228
Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2229 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2285
Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2286 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2345
Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2346 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2404
Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2405 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2455
Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2510
Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2511 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2565
Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2566 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2616
Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2617 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2668
Query: 2086 DLMREYQNLKSAVSKVLENA 2105
E Q L + V E A
Sbjct: 2669 S-AEELQRLAQGHTTVDELA 2687
Score = 84.0 bits (206), Expect = 6e-15
Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)
Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
G+ E++R ++E+LK ++ +R E+ L +E + +A+ + E
Sbjct: 1076 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1129
Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
E K L + +AQ ++ Q T + ++ +E GE L + V+ +++
Sbjct: 1130 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1184
Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
+ QL +Q + + LE + Y + WL R + +
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1244
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
+ + +QL +A++EEI +++ Q I D+ +A+L+
Sbjct: 1245 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1304
Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
++V + YS + + + + + L++ + +Q +A
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1364
Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
L+ V+ LE Q ++A+A ++ K + ++ + S++
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424
Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
+ ++Q +E I+ K QA+ + EEI+ ++ +L + A+ +LQ ++
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1484
Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
R E E A+ + QV+D + + +QA V E +++ + E+ K+
Sbjct: 1485 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1538
Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ L + L L R+ +++R R + + E E + S AE
Sbjct: 1539 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1592
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
TA +L +LQE A+ L+++ ++ + + E +E+ +RW +
Sbjct: 1593 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1643
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ ++ ++Q ++ ++ Q+ ++ E AE + +A +Q+ ++
Sbjct: 1644 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+E A+Q L R + G +RQ++++ L+ Q + + L
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
K +E L + +A + + K FRE L ++ ++ + A+
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1818
Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
+ + + A+ ++ EK +G+ L++ + L++ + RL+ L
Sbjct: 1819 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873
Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
E R+ +E A H +ADI SEL Q ++ L Q + E
Sbjct: 1874 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1928
Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
+L L+ + + E++ + NA E L KE
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1968
Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
A L + L+ E + R + +V LA EE + Q +A L+EV L V+E
Sbjct: 1969 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2026
Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
+ +E + + L L + + Q E++ ++ Q+ + +
Sbjct: 2027 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2081
Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
QL + ++ + + E + AE + + A L+ S + + A
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
L A ++A + Q+ Q L+ +A E ++++ Q + +
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201
Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
T+ ++L + L+R+KAE + ++EE+ +++ EE+ RI AL
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258
Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
++K+ + + + ++ E + L QEA R RQ ++ Q +
Sbjct: 2259 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2318
Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
Q Q A + L+ +EL Q L D E + L + F
Sbjct: 2319 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2378
Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
+ + + E L VA + + +ED ++ E +++ R A +V L+Q
Sbjct: 2379 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437
Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
Q HD ++ RE + EL + EK E LL+ S + E+ L E +AL
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497
Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
+S +S ++ +E++ ++LE+ D +KA R ++ + + + Q+++++
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2552
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
+ + + +A E + + Q++L ++ + ELL L+L ++Q
Sbjct: 2553 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
+ + ++ Q A T
Sbjct: 2609 HRAALAHSEEVTASQVAATKT 2629
Score = 72.8 bits (177), Expect = 1e-11
Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)
Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
Q+ + T L AQ A++ H+ V+++ +L W Q L R ++++ S S+ +
Sbjct: 867 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 918
Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
++ E R Q L S YQ L D G D + G C
Sbjct: 919 RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 965
Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
++ + L LE + +R Q SE D+ L++ + R T + +P +
Sbjct: 966 ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 1017
Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
E R+ E K EV+ + + + ++L L + A TLRSEL
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1074
Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
L + V+ L + ++KL + IS V+ E V++ E+ +K + A
Sbjct: 1075 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1126
Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
L+ K + +Q T D + + + +DVE +R +
Sbjct: 1127 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1181
Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
E++ + + WQ + + + LE L Y + L W + +R +Q +
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1240
Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
L D Q + + ++ ++ +E+IE++G
Sbjct: 1241 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1266
Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
V + + K ++ +++ + L + ++ +GS +Q VD
Sbjct: 1267 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1322
Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
L+ +L ++T+Q +K ++ETL +E + EE E+L
Sbjct: 1323 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1367
Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
+A L+ + + ++ A Q E EL + + + +E A D +
Sbjct: 1368 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1418
Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
++++ L L + E + Q A A A + +L + + + + L + T Q G
Sbjct: 1419 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1475
Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
+ E L+AL A EAE + QE E L+ Q+ S +
Sbjct: 1476 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
EL R+ + + Q + + Q E +L+ ++ Q LE +
Sbjct: 1520 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1577
Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
E +Q+++ E + + L+++ A +AE ++QQ + +R LE+
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
Q+ + L+L ++ Q A++++ + + R+ + E A + R E+
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1693
Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
+ + + Q R ++ E + LR + E G+Q
Sbjct: 1694 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1735
Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
L+ ELA +Q + +A+ + +E + +LA + + E A + E+ R+ +K Q L
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
EL E R + L + + + + + A+ ++ + E L +
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1854
Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
+ E + +++ RL E F + E E DI EE + +L+
Sbjct: 1855 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1903
Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
K E+ + ++ Q +Q+ E + KAS E A+ E+E +LG++ + L
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963
Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
+L AAR ++L + A +++ K++++ E E A+
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 2015
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
E ++ K+ E + L+ E+ S A L L + A ++QQ + L +
Sbjct: 2016 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
+ ++ + R + E R ++ E+ +ER AA E L
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2121
Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
K+ Q Q + E + K+ + A +L+Q ++ +
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2169
Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
+ + K F Q R++ + ++ LT + LQL +H + ++++LKA E
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2223
Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
+ +++E+ + Q E+L + ++A A+I + D +R+ QE ++++ ++
Sbjct: 2224 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283
Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
RL + E L++ +L + + A L ++ + + L L + L
Sbjct: 2284 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2342
Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
E++ R + R LE+ R L E + + LR A +S
Sbjct: 2343 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2397
Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
+ E ++ K ++ ++ +TE + K L+ + +I
Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2457
Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
++R + KL++E + L L S E QT +Q + L +E + Q Q F
Sbjct: 2458 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2499
Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
S+ +S+ E+E +L++L + +L+ ++ ++ Q+ R+ ++ S+
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559
Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
+A+ R Q+ L Q+ + + LL E L++ L + H
Sbjct: 2560 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2609
Score = 66.6 bits (161), Expect = 1e-09
Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)
Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1146 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1198
Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1199 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1258
Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1259 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1318
Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1319 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1365
Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1366 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1420
Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1421 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1480
Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1601 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654
Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1655 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1708
Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1709 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
E + EM++ L + E K + + E ++ + A+ L
Sbjct: 1758 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1813
Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
E+++ + EE+ R + V + RL + E L ++E E E
Sbjct: 1814 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1871
Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
L++ R + Q +++ LAQ ++ S + + L +
Sbjct: 1872 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1931
Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
L E A + E E G + + + LR S + + LE+ RQ A ++ R
Sbjct: 1932 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1985
Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
+ ++ E ++ E K ++ + + ++ +RL + ++E
Sbjct: 1986 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2039
Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
L + + E A A+ KE ++Q LQ+ Q L EE E+
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099
Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
R++ + Q+++ + L+++ + + + + +A+ + +R Q
Sbjct: 2100 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2158
Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
+ + + + +E+ + + L Q + L L LE D +KN + L
Sbjct: 2159 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2217
Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
AE + +Q Q++ EL ++++ L + ++
Sbjct: 2218 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2251
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 983 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1030
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1031 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1088
Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1147
Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1148 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1189
Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1190 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1245
Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1246 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1298
Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1299 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1358
Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1359 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1418
Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1537
Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1538 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1592
Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1593 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1650
Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1651 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1711 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1769
Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1770 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1821
Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1822 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1871
Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1872 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1916
Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1917 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1949
Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1950 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2009
Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2067
Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2068 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2110
Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2165
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2166 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2218
Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2278
Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2279 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2330
Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2331 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2371
Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2372 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2425
Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2426 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2467
Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2468 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2509
Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2510 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2560
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
R QH + V++ +E L QQL++ LA +
Sbjct: 2561 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2595
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2596 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2649
Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2650 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2706
Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
E+L + A QRQ+ T L L+ Q
Sbjct: 2707 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2737
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 267 bits (683), Expect = 3e-70
Identities = 593/2877 (20%), Positives = 1111/2877 (38%), Gaps = 509/2877 (17%)
Query: 23 DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP E+GR
Sbjct: 175 DERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 232
Query: 83 MKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNL 142
R H + N+ AL +L R++KLVNI + DIADG P + LGL+WTIIL+FQI ++
Sbjct: 233 --RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI---- 286
Query: 143 PQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKD 202
S S D AK+ LL W Q G+ +
Sbjct: 287 ------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQGLRCDN 319
Query: 203 FGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDVD 262
F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG+ RLLDPEDVD
Sbjct: 320 FTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVD 379
Query: 263 VDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF---------- 312
V +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 380 VPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWMRHHTAA 438
Query: 313 --KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIE 366
+R F+E+++ QF E +L + ++ + YQS + ++K
Sbjct: 439 FEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGY 498
Query: 367 HLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALR 426
H + GKL + L ++ R + ++ L G L +A+ L+
Sbjct: 499 HPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 557
Query: 427 EEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRAF--HE- 465
++ + + + A ++R L++ ++ Q ++R + HE
Sbjct: 558 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER 617
Query: 466 ------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA 519
Y R G+ P Q+ V+ S ++E L+Y L LL
Sbjct: 618 LVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQDLLAWV 669
Query: 520 ESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTA 567
E L S + G + Q ++ + + IE ++ E Q+ T
Sbjct: 670 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----QLSPATR 724
Query: 568 EMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EEVISNW- 615
Y G ++ K +N + A+ R+L S + + ++ EEV +W
Sbjct: 725 GAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWS 782
Query: 616 DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTAMNDAGN 665
DR N A +++ LE EK + + +NA R P A+ +
Sbjct: 783 DRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWS 842
Query: 666 FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFAT 725
++++ C + LK+ N + + F +V++ A+ L
Sbjct: 843 WMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------------LQKLQE 880
Query: 726 EAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEM 785
+K S + ++ L+QD +D ++++ + K A + + P+ M
Sbjct: 881 ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 940
Query: 786 FATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEI 837
+ +++ + K EC QL+ P + ++ S S + +
Sbjct: 941 RGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSEAAVPSV 991
Query: 838 ITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRL 897
++ Q + ++ +T +E Q++ VTL + L H D L
Sbjct: 992 CFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-HVDMKSL 1030
Query: 898 QRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGD-- 955
+A+QS+ + + R +K EE R L + Q L + D
Sbjct: 1031 --------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLRDSQDAG 1081
Query: 956 ---PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KLHKQWKD 1010
PE+ L E+ S C L + +QG QE R + + KD
Sbjct: 1082 GFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRCISELKD 1128
Query: 1011 --LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKIIKEHRV 1063
LQ EA H L L +D E R EC + + K + EG K +
Sbjct: 1129 IRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKGV----- 1177
Query: 1064 FFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDP 1123
RL E + LP P T LR+ ++ T KL +
Sbjct: 1178 ------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLGKLEQVR 1215
Query: 1124 DKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG 1173
Y + S + +E QLK + K +++++R
Sbjct: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1275
Query: 1174 VTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALVTLLSEV 1224
+ T L+ L+ EV + E ++ + +A+L ++A++
Sbjct: 1276 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1335
Query: 1225 EKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQQLLLHH 1278
++ L G ++Y + L + ++ QEQ A+ E L + Q LL
Sbjct: 1336 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI 1395
Query: 1279 QQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRGHEELRK 1316
++ +++ +R +Q I + E L + +E
Sbjct: 1396 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1455
Query: 1317 LESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLS 1376
L + L + + I TLR+ E E E Q ER L +
Sbjct: 1456 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER------LAEVE 1503
Query: 1377 SELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKEQVKKLE 1431
+ LE+ ++ ++ QAE KE E+ + QQQ +SI+E++++L
Sbjct: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1563
Query: 1432 DTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQ 1491
+ E +I+ + E I +L A E + ++ ++ +
Sbjct: 1564 QSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAE 1620
Query: 1492 EIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTIL 1548
E E++ +EEA+ + V + +A++ ++++ E RE + L+ L
Sbjct: 1621 EAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA--L 1675
Query: 1549 GHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSA 1608
L Q EE R+++Q+ E ++ V ++ + E L S
Sbjct: 1676 EELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA---------------ELQSK 1718
Query: 1609 ITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAHWQ---- 1658
+F+ ++ S +E A+ Q E+ RRA+++ A E L WQ
Sbjct: 1719 RASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1776
Query: 1659 -----RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFY 1713
RL+ E + L + EA+ E + A R G+ + Q E+ Q
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEK 1833
Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
+ L + +A++ ++ ++ EQ +++ + L + + + + + Q+ +
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1893
Query: 1774 LLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------VESKKGE 1819
L +++ L+ E ++TSE S + R ++ A E E K +
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953
Query: 1820 LQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEEASQVVE 1861
Q + A KL ++G A ++ L + +AE+ E ++ E
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ERLRRLAE 2008
Query: 1862 RRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALES 1921
L E H + I +L Q +A++S + + L+E L Q + + +
Sbjct: 2009 DEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 2066
Query: 1922 AAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQNLLGTK 1969
S + KA+ L++G S EQ A QL E ER + +
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAE 2124
Query: 1970 QSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDEL 2028
+ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++L++ +
Sbjct: 2125 ERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE----- 2178
Query: 2029 NSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM 2088
K Q +K AFA V ++ L+ T + ++ + +G+
Sbjct: 2179 ---------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Query: 2089 REYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTS 2147
E + + A + ++ V + E+ A ++ + A K+ + + +
Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2287
Query: 2148 KGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRD 2207
+ + K+ ++ K E T L ++E+ + LR+ L D + D
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 2208 EIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELHSKVNDL 2261
E + A S ++ L + EEL K + E +N+AL L + K N
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KDNTQ 2400
Query: 2262 KELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFT 2321
+ L + E + A L + A + ++A+ +D Q EK + +
Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE---KMQ 2454
Query: 2322 KVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
V+E+ A+ E + A ++ + +Q++ + ++ + +LE
Sbjct: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514
Query: 2377 SLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRT 2436
A ++ E S+ QA +E ++ F + +E E + A +E
Sbjct: 2515 MSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTLV 2568
Query: 2437 GDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEE 2495
++ + HD + + +++++ + + + + QE + L L + + ++Q++
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE------- 2619
Query: 2496 FQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKK 2554
Q L++ QALQ SE S + R + ++E+ F E + +++Q E++
Sbjct: 2620 ------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQLREEQQ 2672
Query: 2555 NEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKE 2614
+ ++E L+A+ E ++R Q +EEG QE L ++ ++
Sbjct: 2673 RQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ELQQLEQQ 2716
Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL 2671
+ + ++ +E++ L E LQ + +A LA +E S+ K L +D L
Sbjct: 2717 RRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGRDAL 2770
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 386 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 445
Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 446 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 488
Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 489 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 537
Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 538 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594
Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 651
Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 652 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 708
Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 709 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 760
Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 761 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 818
Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 819 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 876
Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 877 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 936
Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 937 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 991
Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
V + ++AQ + L L + +++ +++ L
Sbjct: 992 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 1051
Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 1052 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1111
Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 1112 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1166
Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1167 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1224
Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284
Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1285 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344
Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1345 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1404
Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1405 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1462
Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1463 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1518
Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
K + EV E D + +
Sbjct: 1519 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1556
Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
EE + +SE R + + ++I RLQ +A
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1601
Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1602 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1651
Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1652 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1706
Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766
Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
EL+ W L L L + +QK +A +E E E
Sbjct: 1767 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1807
Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1861
Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1862 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1918
Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1919 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1971
Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 2026
Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 2027 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 2068
Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2128
Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 2129 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2187
Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2188 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244
Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2245 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2302
Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2362
Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422
Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2423 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2479
Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2534
Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2535 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2580
Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2581 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2621
Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2622 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2715
Score = 123 bits (309), Expect = 7e-27
Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)
Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 684 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 738
Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 739 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 794
Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
+ + EL + + +L G L E H A R T E
Sbjct: 795 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 833
Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 834 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 872
Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 873 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 912
Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 913 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 969
Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
++ + K S + A + A+E + ++E H + H+
Sbjct: 970 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 1022
Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 1023 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 1082
Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 1083 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1141
Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 1142 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1200
Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1201 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1248
Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1249 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1301
Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1302 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1361
Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1362 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1418
Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1419 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1478
Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
++ L R + E L V+ E Q ++ ++ Q + +QQ++Q
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1535
Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
+R + A + S Q+ ++Q S EA + RQ AE ++
Sbjct: 1536 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1582
Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
+ + + EE+ LE E + G + ELQ L+ R + + ++A
Sbjct: 1583 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1631
Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
++E+L R Q+ + + EV L ++Q L L A E LR
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1691
Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
+ ++QV Q + L ++ Q E SL+++ A E
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1747
Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
+ R E+ ++++ W A E + R + + K + + +K EE
Sbjct: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807
Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
R + EE R +E+ ++ R + T Q R +A Q +Q +
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867
Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
LEEE+ L+ ++ +T K + + ++ KV M EVLL
Sbjct: 1868 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1909
Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
+ +S EK ++ + E EA R R E+ + +L+ L +++ E+ A
Sbjct: 1910 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1962
Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
++ ++ + L + +A E + E ++ L EK+A+ + + L++
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 2022
Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
H+ ++ +R+ ++ LE LV+D ++++I L++ ++ + E
Sbjct: 2023 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 2082
Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
L + ED ++ E + + + E + + LA K
Sbjct: 2083 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2142
Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
A +EE+ + ++ + + + A LQ ++ LQ + +++ Q+
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2198
Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
Q L+ LQ+ S D L+ + +A A + E Q A++ +QV+ L
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258
Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
+EQA+ + L + + A+ Q EQT+ QK
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2318
Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
Q LT EE H K+ L D++LQ +K +E A SQV++
Sbjct: 2319 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2365
Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
+ SV +E+++KL + E+ E++ + + R +N +E+ ++
Sbjct: 2366 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2409
Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
+ + + V ++ LA D A+ A+ + LK+ A+QE K E
Sbjct: 2410 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2468
Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
L+ QK+ E +DKE + +Q + E + FQ LE +R++++S +
Sbjct: 2469 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527
Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
E++ Q+R +E + +Q I E L ++ + L+ L I S+ +A++ L
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2585
Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
+ I + +R L E +++Q + Q+ L+ + + LSEK L
Sbjct: 2586 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2640
Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
Q I+Q + K+ L D+V+K + + Q + + E L A E
Sbjct: 2641 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693
Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
+ E E K E L +L++ + + +L + + RL+E + L+ +H
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2742
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1273 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1319
Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1320 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371
Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1372 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430
Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1431 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1486
Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
L E E+L+E +A + E + +A + K + + R
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1546
Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606
Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1662
Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722
Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1842
Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1843 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1894
Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1952
Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1953 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012
Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072
Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132
Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 2133 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2181
Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2241
Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
+ + E L ++S EE + + A
Sbjct: 2242 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2276
Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
A +A+ QA ++ DA A Q + L
Sbjct: 2277 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334
Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2385
Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2386 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444
Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2445 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2500
Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2501 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2543
Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2544 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2593
Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2647
Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2648 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2703
Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2760
Query: 6406 ALLP 6409
LP
Sbjct: 2761 KTLP 2764
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1281
Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401
Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1402 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1461
Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1462 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1520
Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1521 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1577
Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1578 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1625
Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1626 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1679
Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
++A+ A L EVE AE T L+ L
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1736
Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
H +V + E E E+ + R + S+ Q
Sbjct: 1737 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796
Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
A Q AER K +E E LE G Q+ + +I
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1856
Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1973
Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 2028
Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088
Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
E +K++AE A + R+L K +L E+
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208
Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2209 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262
Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322
Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
L L EE Q + L+ + + S VEE LF
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2368
Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
++ EE+ K K +NR +I L D
Sbjct: 2369 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2398
Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2399 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2458
Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2459 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564
Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624
Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2625 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2659
Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719
Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770
Score = 104 bits (259), Expect = 4e-21
Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
L+TI+ + + E + E++L Q TL A K + Q T D
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284
Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
+ AQ + + L E +++ R+ Q + W + + Q D+ L R
Sbjct: 1285 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344
Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
Q++++R + +L D + A + + Q + ++L Q Q L
Sbjct: 1345 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1392
Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
EEI+ ++ + A Q + +K EL+L + + V KK + + S
Sbjct: 1393 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1447
Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
+ I E V+ T + E+ L Q++ ++ ++ EE L Q+ + + +
Sbjct: 1448 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1500
Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
VE LEK LA + A++ A K+L +QE R+ A D + QK+ +
Sbjct: 1501 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
E L + E Q E+ ++E+ I+ ++Q+ T + EL ++
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616
Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
+R +E E + Q AE L++ D +Q + + S ++A KQ L++
Sbjct: 1617 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674
Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
L ++A+R + + + +Q AL AQ ++L +R + +EKT
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1727
Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
L Q ++H RE ++ + + A+ L+ +Q NE L
Sbjct: 1728 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1833
Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
Q + + EL A+ + +Q E L LQR
Sbjct: 1834 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1882
Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
E L +L + + V++A K +E+ ++ +E
Sbjct: 1883 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1934
Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
EL + R+ + + + L+ +D R + +++A +GEA + + +
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1994
Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
+K L + + QR L E + E+ QL + S E Q
Sbjct: 1995 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 2046
Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
+ E+TL +++ + A + + L R+ + ED + E
Sbjct: 2047 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 2106
Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
AR + + + E + E E R+ +S+ + E +R +L+ + R+KA++
Sbjct: 2107 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2157
Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
L + QE R++Q+ QE Q K L + + H+ A
Sbjct: 2158 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2194
Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
+ + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A + VE AE
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2252
Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
+S E Q + E+L +++ EQ+ A R ++
Sbjct: 2253 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2290
Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2339
Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
N E++ L+ +A++ + + + S + + R A+++ IL D
Sbjct: 2340 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2396
Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
D F +++ E + Q+ ++ S A L L E +L QQ++
Sbjct: 2397 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2446
Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
+ ++ + +Q+ A E L Q+ Q++ +QE D+E +
Sbjct: 2447 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2491
Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
Q+ Q T E +E+ A+ E L++ + E A Q K AEE
Sbjct: 2492 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551
Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
EK + +EL+ Q +V L + Q Q + E+ + EL R+ +KL ++
Sbjct: 2552 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2604
Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
L +LK++ VQ +++L E S L E D+ +Q +F+EQ +L +
Sbjct: 2605 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2659
Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2710
Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
QL +Q + LL EE++ + +L+ + E+ L + V ++ + + GR+
Sbjct: 2711 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2769
Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2770 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2810
Score = 100 bits (248), Expect = 8e-20
Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)
Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 529 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 585
Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 586 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 638
Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 639 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 695
Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 696 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 750
Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 751 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 808
Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 809 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 865
Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 866 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 925
Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
+++ +L R G G E +L SH +L + +
Sbjct: 926 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 985
Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 986 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 1043
Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 1044 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 1099
Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 1100 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1155
Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1209
Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269
Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
K++ ++++ L A EV + + H E W++
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1324
Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384
Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++ S
Sbjct: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1444
Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
G S +I+EY L S+ + Q + ++ ++ + + + +
Sbjct: 1445 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499
Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
+EV +L+K Q +L ++ + + KE + +Q +V +E +
Sbjct: 1500 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1548
Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
+ L+ L+ Q + E+ A+ Q ++ ++ E R+ L + E+Q+
Sbjct: 1549 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1607
Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
LQ++ E Q + +E+A++L + Q S+ R +L+S+ A + +E
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1667
Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
K L + Q + L+ + + + L++ EA L K
Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1718
Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
+ EK Q++ + + E QQQ ++ R + + E
Sbjct: 1719 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1766
Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
L +W + + + + + E+E+Q E + GKA+
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1817
Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
E V Q EL Q+L+++ + + A++ + ++L+RL E ++
Sbjct: 1818 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1861
Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
G++Q +L ++ + L+ +A ++L+ EL AE + LL S E
Sbjct: 1862 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913
Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
+ + + LE+ ++ + R + +L E+ +
Sbjct: 1914 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971
Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
+ E L E +T + KE + ++++ E+ R +EE A+ + ++E
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031
Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
R + R + L+ L Q + +EEEI +L+ S ++ G +
Sbjct: 2032 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 2084
Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
+ + DT + K+ LE + + + RE ER K L E EA R RK
Sbjct: 2085 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2142
Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
+ +E+LK R+ E + L LA+E + K + E
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2187
Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
K + A K + LQQT+ + + +R + EA E ++ ++ + + QS
Sbjct: 2188 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244
Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
Q + S E + + + +++ K Q + R + +
Sbjct: 2245 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2302
Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
++ HK E+ A E L L+++ + DH + L + LQ K
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2350
Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
A + A R +E EL + + L + +A + A + D + + + AE
Sbjct: 2351 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2409
Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
+KQV +E AR S+ A ++ A++ ++ + +K+++ + Q
Sbjct: 2410 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2456
Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
+E LK+E + LQ + Q RR E + +AQ + + + F + L++++
Sbjct: 2457 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
A + +V ++++ + E K+ + ++ +L Q +Q E +Q
Sbjct: 2516 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2574
Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
R + HD + E +A + E + EA K L L +E + ++
Sbjct: 2575 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2622
Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
Q+ + ++ L +K+ + ++ +EQ +LE L Q V ++L Q R Q+ M
Sbjct: 2623 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2678
Query: 4358 EWAEEQQPNIA 4368
E +E+Q +A
Sbjct: 2679 E--QERQRLVA 2687
Score = 98.6 bits (244), Expect = 2e-19
Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)
Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
H++ L K+ A E + E Q Q + LG + + L +AE L E S
Sbjct: 1142 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1195
Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
+ L L+ SLS I + +T+ + +++ + L+ A+A
Sbjct: 1196 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1254
Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
+ + L+ + + L+ + Q+ + A D+L G EV ER+Q G + E +
Sbjct: 1255 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1313
Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
++++ +LL+ + + +TD +++ + L ++LR + + D L +
Sbjct: 1314 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1358
Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
WL+D ++ Q+ + P D + R ++ + L+ E +
Sbjct: 1359 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1399
Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
V + A I IKD E L + ++ + + S
Sbjct: 1400 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1436
Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
KK V++ ES + +++D+ E + + L +E E +
Sbjct: 1437 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1490
Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
+ E ++ ++ L + L E ++ K +A R +EL ++ + E+ + E D
Sbjct: 1491 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1548
Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
Q + + ++L+ ++ +E + A++ Q E A+
Sbjct: 1549 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1583
Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
++++ ++ +L++ + + L +L + AE E L R +
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643
Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
+K +A +L S+ +A + + EK ++Q +E L A+ A + ++ +A
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1692
Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
++ + + ++ Q +A Q + +A + Q+ S+QE+ + + EE + +
Sbjct: 1693 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752
Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
Q + ++A ++ EL ++ ++ +L L E+ ++ + KQ E + E
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1811
Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
+ + + RE ++ ++ + L+E G Q Q L + Q L+R+ E
Sbjct: 1812 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1859
Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
+ Q+ + LEE L + R A A + + LE L+++ + E E
Sbjct: 1860 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1902
Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
V L + + E+ RS++++ ++ ++ + +E+ + A+ D
Sbjct: 1903 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1961
Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
++ + E + + ++ + + + LKEK + L+ + + R L
Sbjct: 1962 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
A+ + E+ + + + EL+ Q + +++ + EEI+ + A +
Sbjct: 2022 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 2080
Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
+ S E+ R + + +A Q++L+ +E R R+ + + E
Sbjct: 2081 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 2138
Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
+ A+ E+ + +A R + ++S Q Q E ++ E+ + V Q
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
EQ L+Q T Q+ ++L+ + E +E +A +AE + Q+ E
Sbjct: 2199 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2250
Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
R + + + L +A + + Q Q R Q+ +A++
Sbjct: 2251 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2304
Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
K F Q + + + Q++ + E H+ N++ E+ + ++A
Sbjct: 2305 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2351
Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
+ T A Q E L ++++QM++ LSK + + E+ NR
Sbjct: 2352 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2392
Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
L K Q+ LQ E++ + RL AQ+ R+ QL+ + LA
Sbjct: 2393 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2441
Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
EK+ +KE ++V ++ LK EA
Sbjct: 2442 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2466
Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
L ++Q+KE+ Q + + E + Q + E Q+ L++ + + + R K
Sbjct: 2467 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2524
Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
+ V + S E + +Q E+ +K L + +L +E ++
Sbjct: 2525 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2566
Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
L++T+E++ ++H +L + +L+ +Q+ AK KSE++ + QE
Sbjct: 2567 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2620
Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
L QE + L Q + E D+ + ++ ++ Q + V ++
Sbjct: 2621 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2666
Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
+ + + R + + Q+ Q + E R + + +R +++ QQ+++ + EE
Sbjct: 2667 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2723
Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
++ + N+ +E QL +++ H A+ +EV
Sbjct: 2724 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2752
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1310 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1369
Query: 639 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1370 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1429
Query: 690 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1430 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489
Query: 747 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1546
Query: 805 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
+ + + L++L +Q + S +I E I V+
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606
Query: 843 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1666
Query: 884 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725
Query: 936 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785
Query: 993 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1839
Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1840 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1888
Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1939
Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
+RL+ L E + + D + + + + L L+ +
Sbjct: 1940 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1979
Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1980 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 2026
Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 2027 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 2080 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 2130
Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2184
Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2185 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2241
Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2242 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301
Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361
Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2362 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2418
Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2419 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2478
Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2479 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2537
Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2538 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2588
Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2643
Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2644 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2698
Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2699 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2749
Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2750 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2801
Query: 2086 DLMREYQNLKSAVSKVLENA 2105
E Q L + V E A
Sbjct: 2802 S-AEELQRLAQGHTTVDELA 2820
Score = 84.0 bits (206), Expect = 6e-15
Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)
Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
G+ E++R ++E+LK ++ +R E+ L +E + +A+ + E
Sbjct: 1209 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1262
Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
E K L + +AQ ++ Q T + ++ +E GE L + V+ +++
Sbjct: 1263 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1317
Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
+ QL +Q + + LE + Y + WL R + +
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1377
Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
+ + +QL +A++EEI +++ Q I D+ +A+L+
Sbjct: 1378 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1437
Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
++V + YS + + + + + L++ + +Q +A
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1497
Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
L+ V+ LE Q ++A+A ++ K + ++ + S++
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1557
Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
+ ++Q +E I+ K QA+ + EEI+ ++ +L + A+ +LQ ++
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1617
Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
R E E A+ + QV+D + + +QA V E +++ + E+ K+
Sbjct: 1618 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1671
Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
+ L + L L R+ +++R R + + E E + S AE
Sbjct: 1672 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1725
Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
TA +L +LQE A+ L+++ ++ + + E +E+ +RW +
Sbjct: 1726 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1776
Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
+ ++ ++Q ++ ++ Q+ ++ E AE + +A +Q+ ++
Sbjct: 1777 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835
Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
+E A+Q L R + G +RQ++++ L+ Q + + L
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895
Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
K +E L + +A + + K FRE L ++ ++ + A+
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1951
Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
+ + + A+ ++ EK +G+ L++ + L++ + RL+ L
Sbjct: 1952 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 2006
Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
E R+ +E A H +ADI SEL Q ++ L Q + E
Sbjct: 2007 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 2061
Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
+L L+ + + E++ + NA E L KE
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 2101
Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
A L + L+ E + R + +V LA EE + Q +A L+EV L V+E
Sbjct: 2102 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2159
Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
+ +E + + L L + + Q E++ ++ Q+ + +
Sbjct: 2160 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214
Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
QL + ++ + + E + AE + + A L+ S + + A
Sbjct: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274
Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
L A ++A + Q+ Q L+ +A E ++++ Q + +
Sbjct: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334
Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
T+ ++L + L+R+KAE + ++EE+ +++ EE+ RI AL
Sbjct: 2335 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391
Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
++K+ + + + ++ E + L QEA R RQ ++ Q +
Sbjct: 2392 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2451
Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
Q Q A + L+ +EL Q L D E + L + F
Sbjct: 2452 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2511
Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
+ + + E L VA + + +ED ++ E +++ R A +V L+Q
Sbjct: 2512 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570
Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
Q HD ++ RE + EL + EK E LL+ S + E+ L E +AL
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630
Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
+S +S ++ +E++ ++LE+ D +KA R ++ + + + Q+++++
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2685
Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
+ + + +A E + + Q++L ++ + ELL L+L ++Q
Sbjct: 2686 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
+ + ++ Q A T
Sbjct: 2742 HRAALAHSEEVTASQVAATKT 2762
Score = 72.8 bits (177), Expect = 1e-11
Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)
Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
Q+ + T L AQ A++ H+ V+++ +L W Q L R ++++ S S+ +
Sbjct: 1000 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 1051
Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
++ E R Q L S YQ L D G D + G C
Sbjct: 1052 RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 1098
Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
++ + L LE + +R Q SE D+ L++ + R T + +P +
Sbjct: 1099 ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 1150
Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
E R+ E K EV+ + + + ++L L + A TLRSEL
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1207
Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
L + V+ L + ++KL + IS V+ E V++ E+ +K + A
Sbjct: 1208 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1259
Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
L+ K + +Q T D + + + +DVE +R +
Sbjct: 1260 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1314
Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
E++ + + WQ + + + LE L Y + L W + +R +Q +
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1373
Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
L D Q + + ++ ++ +E+IE++G
Sbjct: 1374 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1399
Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
V + + K ++ +++ + L + ++ +GS +Q VD
Sbjct: 1400 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1455
Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
L+ +L ++T+Q +K ++ETL +E + EE E+L
Sbjct: 1456 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1500
Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
+A L+ + + ++ A Q E EL + + + +E A D +
Sbjct: 1501 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1551
Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
++++ L L + E + Q A A A + +L + + + + L + T Q G
Sbjct: 1552 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1608
Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
+ E L+AL A EAE + QE E L+ Q+ S +
Sbjct: 1609 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
EL R+ + + Q + + Q E +L+ ++ Q LE +
Sbjct: 1653 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1710
Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
E +Q+++ E + + L+++ A +AE ++QQ + +R LE+
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
Q+ + L+L ++ Q A++++ + + R+ + E A + R E+
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1826
Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
+ + + Q R ++ E + LR + E G+Q
Sbjct: 1827 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1868
Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
L+ ELA +Q + +A+ + +E + +LA + + E A + E+ R+ +K Q L
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928
Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
EL E R + L + + + + + A+ ++ + E L +
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1987
Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
+ E + +++ RL E F + E E DI EE + +L+
Sbjct: 1988 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 2036
Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
K E+ + ++ Q +Q+ E + KAS E A+ E+E +LG++ + L
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096
Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
+L AAR ++L + A +++ K++++ E E A+
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 2148
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
E ++ K+ E + L+ E+ S A L L + A ++QQ + L +
Sbjct: 2149 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
+ ++ + R + E R ++ E+ +ER AA E L
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2254
Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
K+ Q Q + E + K+ + A +L+Q ++ +
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2302
Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
+ + K F Q R++ + ++ LT + LQL +H + ++++LKA E
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2356
Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
+ +++E+ + Q E+L + ++A A+I + D +R+ QE ++++ ++
Sbjct: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416
Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
RL + E L++ +L + + A L ++ + + L L + L
Sbjct: 2417 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2475
Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
E++ R + R LE+ R L E + + LR A +S
Sbjct: 2476 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2530
Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
+ E ++ K ++ ++ +TE + K L+ + +I
Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2590
Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
++R + KL++E + L L S E QT +Q + L +E + Q Q F
Sbjct: 2591 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2632
Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
S+ +S+ E+E +L++L + +L+ ++ ++ Q+ R+ ++ S+
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692
Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
+A+ R Q+ L Q+ + + LL E L++ L + H
Sbjct: 2693 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742
Score = 66.6 bits (161), Expect = 1e-09
Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)
Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1279 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1331
Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1332 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1391
Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1392 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1451
Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1452 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1498
Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1499 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1553
Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1554 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1613
Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1734 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787
Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1788 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1841
Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1842 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
E + EM++ L + E K + + E ++ + A+ L
Sbjct: 1891 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1946
Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
E+++ + EE+ R + V + RL + E L ++E E E
Sbjct: 1947 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 2004
Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
L++ R + Q +++ LAQ ++ S + + L +
Sbjct: 2005 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 2064
Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
L E A + E E G + + + LR S + + LE+ RQ A ++ R
Sbjct: 2065 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 2118
Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
+ ++ E ++ E K ++ + + ++ +RL + ++E
Sbjct: 2119 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2172
Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
L + + E A A+ KE ++Q LQ+ Q L EE E+
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232
Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
R++ + Q+++ + L+++ + + + + +A+ + +R Q
Sbjct: 2233 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2291
Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
+ + + + +E+ + + L Q + L L LE D +KN + L
Sbjct: 2292 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2350
Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
AE + +Q Q++ EL ++++ L + ++
Sbjct: 2351 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2384
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 1116 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1163
Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1164 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1221
Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1280
Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1281 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1322
Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1323 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1378
Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1379 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1431
Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1432 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1491
Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1492 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1551
Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611
Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1670
Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1671 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1725
Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1726 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1783
Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1784 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843
Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1844 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1902
Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1903 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1954
Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1955 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 2004
Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 2005 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 2049
Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
V TLR+ Q V ++ + K +F+K + E
Sbjct: 2050 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 2082
Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 2083 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2142
Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2200
Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2201 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2243
Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2298
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2299 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2351
Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2411
Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2412 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2463
Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2464 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2504
Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2505 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2558
Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2559 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2600
Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2601 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2642
Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2643 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2693
Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
R QH + V++ +E L QQL++ LA +
Sbjct: 2694 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2728
Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2729 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2782
Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2783 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2839
Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
E+L + A QRQ+ T L L+ Q
Sbjct: 2840 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2870
>gi|19923599 calmin [Homo sapiens]
Length = 1002
Score = 265 bits (678), Expect = 1e-69
Identities = 166/350 (47%), Positives = 218/350 (62%), Gaps = 19/350 (5%)
Query: 18 MQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPC 77
+Q LQ E+E VQKRTFT+WIN HL K PP+ V DLF D++DG L+ALLEVLSG+ L
Sbjct: 23 VQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILMALLEVLSGRNLLH 82
Query: 78 EQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEE 137
E RI + NI ALKFLE +KLV+I++ +IADG PS+VLGL+W IIL+FQI+E
Sbjct: 83 EYKSSSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILFFQIKE 142
Query: 138 LTSNLPQ---LQSLSSSASSVDSIVSSETPSPPSKRKV--TTKIQGNAKKALLKWVQYTA 192
LT NL + SLS + DS SS P+P ++R V + K Q A KALL WVQ
Sbjct: 143 LTGNLSRNSPSSSLSPGSGGTDS-DSSFPPTPTAERSVAISVKDQRKAIKALLAWVQRKT 201
Query: 193 GKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGI 252
K G+ V+DF SWRSG+AF +VI AI P LVD++ S RENLE AF+IA+ L I
Sbjct: 202 RKY-GVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQALENSTRENLEKAFSIAQDALHI 260
Query: 253 PRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF 312
PRLL+PED+ VD PDE+SIMTYVAQFL+ +P++ + D + D+ +P +F +
Sbjct: 261 PRLLEPEDIMVDTPDEQSIMTYVAQFLERFPELE--AEDIFDSDKEVPIESTFVRIKETP 318
Query: 313 KREDRVIFKEMKVWIEQFERDLT------RAQMVESNLQDKYQSFKHFRV 356
++ +F V E ER T + + DK +S K FR+
Sbjct: 319 SEQESKVF----VLTENGERTYTVNHETSHPPPSKVFVCDKPESMKEFRL 364
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 244 bits (623), Expect = 3e-63
Identities = 427/2091 (20%), Positives = 813/2091 (38%), Gaps = 407/2091 (19%)
Query: 19 QRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCE 78
++LQDE+E VQK+TFTKW+NSHLA+ + DL+ D++DG L+ LLEVLSG++LP
Sbjct: 33 KQLQDEREAVQKKTFTKWVNSHLARVS--CRITDLYTDLRDGRMLIKLLEVLSGERLPKP 90
Query: 79 QGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEEL 138
RM RIH + N+ AL+FL+ +++ L N+ S DI DG + LGL+WTIIL FQI++
Sbjct: 91 TKGRM-RIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQD- 148
Query: 139 TSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGI 198
+S ET K+ +AK ALL W Q +
Sbjct: 149 --------------------ISVETEDNKEKK--------SAKDALLLWCQMKTAGYPNV 180
Query: 199 EVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDP 258
+ +F SWR G+AF+++IH RP+L+D + +K + NL++AF +AE LG+ +LLDP
Sbjct: 181 NIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDP 240
Query: 259 EDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRV 318
ED+ VD PDEKSI+TYV + ++ + + +G+ ++L ++ ++
Sbjct: 241 EDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYES---- 296
Query: 319 IFKEMKVWIEQFERDLTRAQMVES--NLQDKYQSFKHFRVQYE----MKRKQIEHLIQPL 372
+ ++ WIEQ L + S +Q + Q+F +R + ++ +E L+ +
Sbjct: 297 LASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTI 356
Query: 373 H-------------RDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLY 419
R+GKL D + ++W+R L+K+ +
Sbjct: 357 QSKMRANNQKVYMPREGKLISD---INKAWER-----------LEKA-----------EH 391
Query: 420 RAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD-----------------AHKRA 462
E+ALR E+ Q+ E+ A RK + L A K+
Sbjct: 392 ERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKK- 450
Query: 463 FHEIYRT------RSVNGIPVPPDQLEDMAERFHFVSSTS--------------ELHLMK 502
HE T V + +LE AE +H + + EL +
Sbjct: 451 -HEAIETDIAAYEERVQAVVAVARELE--AENYHDIKRITARKDNVIRLWEYLLELLRAR 507
Query: 503 MEFLELKYRLLSLLV--------LAESKLKSWIIKYGRR-ESVEQLLQNYVSFIE----- 548
+ LE+ L + + E K+ YG+ VE LLQ + + +E
Sbjct: 508 RQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKH-TLVEADIGI 566
Query: 549 NSKFFEQYEVTYQILKQTAEMYVKADGSV-EEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
++ + Q E Y D V + M+F + Q L+ E R+
Sbjct: 567 QAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ---LAAE---RRAR 620
Query: 608 LEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMND----- 662
LEE W ++ +A + W+ + EK+L+ + K ++ + +H A D
Sbjct: 621 LEESRRLW-KFFWEMAEEEGWIREKEKILSSDDYGKD--LTSVMRLLSKHRAFEDEMSGR 677
Query: 663 AGNF--LIETCDEMV------SRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT 714
+G+F I+ ++M+ S ++++++ + +W A +++ ++K+
Sbjct: 678 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQW----------ANLEQLSAIRKKRL 727
Query: 715 DCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLIT 774
+ L F +A +DI DA I K
Sbjct: 728 EEASLLHQFQADA----------------------DDI-------DAWMLDILKIV---- 754
Query: 775 KESPQEEGKEMFATMSKLKEQLTKVKEC--YSPLL--YESQQLLIPLEELEKQMTSFYDS 830
S + G + ++T S +K+ +E Y P L Q +P E E D
Sbjct: 755 --SSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESP-----DV 807
Query: 831 LGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLK 890
G+++ I + A+ + L KQ Q+ TL L + S++ + + +
Sbjct: 808 RGRLSGIEERYKEVAELTRLRKQALQD----------TLALYKMFSEADACELWIDEKEQ 857
Query: 891 HFDQTRLQRQIADIHV---AFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQ 947
+ ++ ++ D+ V F+S+ + + V +++ ++ S EK ++ Q
Sbjct: 858 WLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ 917
Query: 948 EGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQ 1007
+ L + F +L R +A L A L E + K+ +
Sbjct: 918 DKLNTRWSQ----------FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIES 967
Query: 1008 WKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD 1067
+DL + + + R L ++E ++L +E +EK+ EH
Sbjct: 968 TQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKE--------AEKLESEHP----- 1014
Query: 1068 KGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK 1127
++ ++ L + D TLK A++ + K +
Sbjct: 1015 -------DQAQAILSRLA-------EISDVWEEMKTTLKNREASLG--------EASKLQ 1052
Query: 1128 DYTSRFSEFSSWISTNETQLKG-------IKGEAIDTANHGEVKRAVEEIRNGVTK---- 1176
+ +F SW+S +T + + E + T H +K ++ K
Sbjct: 1053 QFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLT-QHENIKNEIDNYEEDYQKMRDM 1111
Query: 1177 -----RGET---LSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLL---SEVE 1225
+G+T +L+ RL+ L + NE K + L S A L + E
Sbjct: 1112 GEMVTQGQTDAQYMFLRQRLQALD--TGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAE 1169
Query: 1226 KMLSNFGDCVQYKEI-------------------VKNSLEELIS---------------G 1251
L+N + + E+ ++ EE I+
Sbjct: 1170 AFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNIN 1229
Query: 1252 SKEVQEQAEKILD--TENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDR 1309
S +QE+ + I D +N A +LL+ + + + +D Q+ + D
Sbjct: 1230 SDRIQEKVDSIDDRHRKNRETASELLM-RLKDNRDLQKFLQDCQELSLWINEKMLTAQDM 1288
Query: 1310 GHEELRKLES----------------------TLDGLERSRERQERRIQVTLR------K 1341
++E R L S +G++ E+ E V +
Sbjct: 1289 SYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKM 1348
Query: 1342 WERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE---QTKEFSKRTESIAVQAEN 1398
WE E+ +T + LF + S + L+ LE Q+ ++ K S+ + +
Sbjct: 1349 WEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKK 1408
Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT----LEEDIKTMEMVK--------- 1445
+++ + + + LQ QA+++ ++ K ++ L K ME+++
Sbjct: 1409 QQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNL 1468
Query: 1446 --TKWDH-FGSNFETLSVWITEKEKELNALETSSSAMDMQ--ISQIKVTIQEIESKLSSI 1500
+K H F + E +W+ E+ + + + +Q I + + +EI+ I
Sbjct: 1469 LASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRI 1528
Query: 1501 VGLEEEAQSFAQFVTTGESARIKAKLTQIRRYG----EELREHAQCLEGTILGHLSQQQK 1556
+ E +Q+ ++ + I+ +L +++ EE + + LE H +QQ
Sbjct: 1529 DDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEE---AHRAQQYY 1585
Query: 1557 FEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA 1616
F+ + S E K SA +L++H L QA+E + + S ++
Sbjct: 1586 FDAAEAEAWMSEQELYMMSEEKAKDEQSAV---SMLKKHQILEQAVEDYAETVHQLSKTS 1642
Query: 1617 RKVVNRDSCVQEAAALQQQ-----YEDILRRAKERQTALENLLAHWQRLEKELSSFLTWL 1671
R +V E +++Q Y + A+ER+ L+ +Q L +E+ W+
Sbjct: 1643 RALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQ-LNREVDDLEQWI 1701
Query: 1672 ERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDD 1731
E A S E+ + V + E A + Q + L + L + D
Sbjct: 1702 AEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQER-VDTVNHLADELINSGHSDA 1760
Query: 1732 VKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTT 1791
+ + + L+E W DL ++I+ R L + H+ + + + ++ ++ +
Sbjct: 1761 ATIAEWK-DGLNEAWADLLELIDTRTQILAASYELHKFYHD---AKEIFGRIQDKHKKLP 1816
Query: 1792 SEISIMDHQVALTRHKDHAA---EVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAED 1848
E+ D T + H ++++ +++ LQ A+L + + +Q + +
Sbjct: 1817 EELG-RDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENE 1875
Query: 1849 CFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
+ ++ E R++ L + + + + ++ + + + K
Sbjct: 1876 VLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEK 1926
Score = 135 bits (339), Expect = 2e-30
Identities = 295/1654 (17%), Positives = 650/1654 (39%), Gaps = 170/1654 (10%)
Query: 2967 QALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEIL---DALQKAEPRTEDLKSQL 3023
Q LE L K + + L +++ + + +V G+ +L D LQK D+ Q
Sbjct: 509 QRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQA 568
Query: 3024 NELC-------RFSRDLSTYSGKVSGLIKE--------YNCLC-LQASKGCQNKEQILQQ 3067
+ +F+ D Y +I++ Y LC L A + + +E
Sbjct: 569 ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLW 628
Query: 3068 RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK 3127
+F + + W + K D ++++ V L K + F E + +
Sbjct: 629 KFFWEMAEEEGW-IREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKE 687
Query: 3128 GELLSTLLTKEK--AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPI 3185
GE ++ +E ++ I+ ++ +E W N ++ LE + + F+ A+ I
Sbjct: 688 GE---DMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDI 743
Query: 3186 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3245
W+ K+V SS+ +D + + +K + V EEI Y P L+ L E+A L + A
Sbjct: 744 DAWMLDILKIV-SSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHA 802
Query: 3246 ASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFS------LGIKELQDWMTDA 3299
S R R+S + +Y ++ LT+ + L +A + FS L I E + W+ +
Sbjct: 803 ESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNM 862
Query: 3300 IHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTI 3359
D V+ R LE ++ + + + I + L ++ I
Sbjct: 863 -----QIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ----LMHSGHPSEKEI 913
Query: 3360 QQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQH 3419
+ Q + W+ R K L ALS +Y + W+ + ++
Sbjct: 914 KAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETKSWIREKTKVIESTQDLG 972
Query: 3420 AELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQ--------LELQDLQE 3471
+L + K + ++++ + L ++ + + + Q E+ D+ E
Sbjct: 973 NDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWE 1032
Query: 3472 RYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQ----------------EKL 3515
+ + + ++ ++ KL Q++ RDL F+ WL + Q + L
Sbjct: 1033 EMKTTLKNREASLGEASKL----QQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLL 1088
Query: 3516 DQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESL 3575
Q+ ++ + +E + ++++ +GQ + R+ + QA D L
Sbjct: 1089 TQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDA-QYMFLRQRL------QALDTGWNEL 1141
Query: 3576 RQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKE 3635
+ W+ Q+ LS++ + + + +Q + +L +E V T + E
Sbjct: 1142 HKMWENRQNLLSQS--------HAYQQFLRDTKQAEAFLNN-QEYVLAHTEMPTTLEGAE 1192
Query: 3636 IQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNS-RMGCQATQLTSRYQ------A 3688
+ + + + + A +++ V + ++ + ++NS R+ + + R++ +
Sbjct: 1193 AAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETAS 1252
Query: 3689 LLLQVLEQIKFLEEEIQSLEE-----SESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743
LL L+ + L++ +Q +E +E L++ Y +N+ +K K M
Sbjct: 1253 ELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEA----RNLHSKWLKHQAFM- 1307
Query: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3803
+L + + L +EK L S + + E VK G +H E L+ T T
Sbjct: 1308 -AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--------LHKMWEVLESTTQT 1358
Query: 3804 VRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQ 3863
+ K A+ F+ C L +W+ + + + K +L L K + L+
Sbjct: 1359 KAQRLFDANK----AELFTQSCADLDKWLHGLESQIQSDDYGK-DLTSVNILLKKQQMLE 1413
Query: 3864 QTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQ----LQSDYQDLCSIGKEHVFSLEA 3919
+ + ++ ++ + +A L Q+ D++D +Q+ + +L E +L A
Sbjct: 1414 NQMEVRKKEIEELQSQAQA---LSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLA 1470
Query: 3920 KVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDR 3979
+ H+ +N ++++ W+ + + D +L+T+ + ++ + +EI G + R
Sbjct: 1471 SKEIHQ-FNRDVEDEILWVGERMPLATSTD--HGHNLQTVQLLIKKNQTLQKEIQGHQPR 1527
Query: 3980 LNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLE--HELQK 4037
++++ + ++ + ++Q L K + + ++ ++ LE H Q+
Sbjct: 1528 IDDIFERSQNIVTDSSSLSAEAIRQ----RLADLKQLWGLLIEETEKRHRRLEEAHRAQQ 1583
Query: 4038 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMC 4097
+ + +AW+S Q S + A+ +K + L++ Y + + +
Sbjct: 1584 YYF---DAAEAEAWMSE-QELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLS 1639
Query: 4098 DLSNASVKTT---AKDIQQTEQTIEQKLVQAQNLTQ---GWEEIKHLKSELWIYLQDADQ 4151
S A V + ++ I + +++ ++L + G + +H +L + D +Q
Sbjct: 1640 KTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQ 1699
Query: 4152 QLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV-NTIIEKVNKLTKKEESPEHKE 4210
+ + EL V+ +++ ++ ++ ++ VN L + + H +
Sbjct: 1700 WIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSD 1759
Query: 4211 I-------NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNL 4263
+ LN+ W DL + + + YHD + +K + L
Sbjct: 1760 AATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEEL 1819
Query: 4264 ARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNL----DDKELVKEQTS 4319
R +E L+++ + A+ Q Q+ L D + ++++ +
Sbjct: 1820 GRDQNT-----VETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKREN 1874
Query: 4320 HLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDM 4379
+ + W L D + + +V + + + S ++LM W E+ I + Q P D+
Sbjct: 1875 EVLEAWKSLLDACESR-RVRLVDTGDKFRFFSMVRDLMLWMEDV---IRQIEAQEKPRDV 1930
Query: 4380 A--QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCL 4437
+ + L+ +H I +E++A+ + I+ ++A ++ +K L + +
Sbjct: 1931 SSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMI 1990
Query: 4438 SDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCK 4497
D R ++L + + E QF A + + E + RE I D+V K +K +
Sbjct: 1991 -DKWEDRWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSRE-IGQSVDEVEKLIKRHE 2047
Query: 4498 SAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSE 4531
+ + S T+ + L + EV Q++ E
Sbjct: 2048 AFEKSAATWDERFSALERLTTLELLEVRRQQEEE 2081
Score = 124 bits (312), Expect = 3e-27
Identities = 308/1695 (18%), Positives = 668/1695 (39%), Gaps = 222/1695 (13%)
Query: 6634 FQGLESHMILTETLFRKIISFAVQKETQFHTELM------AQASAVLKRAHKRGVELEYI 6687
F E H+ LT+ L + IS E T ++ ++ A+ + G L+
Sbjct: 225 FNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNA 284
Query: 6688 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQ---- 6743
+ET +++ + S LE +E +I + N + + + Q + N Y+
Sbjct: 285 IETEKMIEKYESLASDLLEWIEQTI-----IILNNRKFANSLVGVQQQLQAFNTYRTVEK 339
Query: 6744 PKLYQVLDDGKRLLISISC------------------SDLESQLNQLGECWLSNTNKMSK 6785
P + + + LL +I SD+ +L + +
Sbjct: 340 PPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRN 399
Query: 6786 ELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEF 6845
EL R E + + R+ ++A WL S RL +P + H
Sbjct: 400 ELIRQEKLEQLARRFDRKAAMRETWL-SENQRLVSQDNFGFDLPAVEAATKKHE----AI 454
Query: 6846 SKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ- 6904
++ A +V++ +L D + + + W LL + A +++L
Sbjct: 455 ETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMN 514
Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQ 6964
L + K+ + +M W+ M+ V+ +D K+ +G + + LQK+ + DI +
Sbjct: 515 LGLQKIFQE--MLYIMDWMDEMK-VLVLSQDYGKHLLG---VEDLLQKHTLVEADIGIQA 568
Query: 6965 LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESW 7024
V VN S + ++ K D +++ M +Q L L E+ LE W
Sbjct: 569 ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLW 628
Query: 7025 SEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7084
+ + + W +EK L D SV L + ED + + E+ +
Sbjct: 629 KFFWEMAE-EEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKE 687
Query: 7085 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7144
G +I + S + + + + WANL+ QL + K L++ S
Sbjct: 688 GEDMIAEEHFG-SEKIRERIIYIREQWANLE----QLSAIRKKRLEEASL---------- 732
Query: 7145 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 7204
L +F+ ++A + + + + D+ E S T L+K+ H
Sbjct: 733 --------LHQFQADADDIDAWMLDILKIVS-SSDVGHDEYS-------TQSLVKK-HKD 775
Query: 7205 VTETLTN---TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7261
V E + N TL ++ + + L +E AE L + +RYK+ ++ Q +D
Sbjct: 776 VAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQD- 834
Query: 7262 TNELLKAATNKDIAD---DEVATWIQDCN--DLLKGLGTVK--------------DSLFF 7302
T L K + D + DE W+ + + L+ L ++ +
Sbjct: 835 TLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAV 894
Query: 7303 LHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLE 7362
++++ QL S I++ Q L+ + + +++ +L + L + +
Sbjct: 895 VNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA-LSIQNYHLECN 952
Query: 7363 ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL 7422
++WI E ++++ +DL+ + +L G ++ L L + +L
Sbjct: 953 ETKSWIREKTKVIESTQDL-GNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLES 1011
Query: 7423 NDKE-----IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQ 7477
+ + R+ ++ W + + R + L + Q FL + + +L +T+
Sbjct: 1012 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGE-ASKLQQFLRDLDDFQSWLSRTQT 1070
Query: 7478 KLAVEISGNY----QHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEF 7533
+A E N + LL Q HE + E+ + ++ + G+ ++ QGQ D + F
Sbjct: 1071 AIASEDMPNTLTEAEKLLTQ---HENIKNEIDNYEEDYQKMRDMGE-MVTQGQTDAQYMF 1126
Query: 7534 -NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
+L L W + + + R+ ++ SQ +Q++ ++ +L Y+
Sbjct: 1127 LRQRLQALDTGWNELHKMWENRQNLL-SQSHAYQQFLRDTKQAEAFLNNQEYVLAHT--E 1183
Query: 7593 VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQE 7652
+P L+ A + + + VE G++L+ + ++ +Q ++ I +
Sbjct: 1184 MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR-IQEKVDSIDD 1242
Query: 7653 KWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEE---LHA 7709
+ + + E +L LKD +K + D E +K+ + ++E LH+
Sbjct: 1243 RHR----KNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHS 1298
Query: 7710 EQMRCKELENAVGS---WTDDLTQ--LSLLKDTLSAYISADDISILNERVELLQRQWEEL 7764
+ ++ + + S W D + + + L+ + + +++ E++ L + WE L
Sbjct: 1299 KWLKHQAFMAELASNKEWLDKIEKEGMQLISE------KPETEAVVKEKLTGLHKMWEVL 1352
Query: 7765 CHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG---DILIEEMIEKLKKD 7821
+ Q++ + N+ +F++ +L +WL +ES++ + D+ ++ K ++
Sbjct: 1353 ESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQM 1411
Query: 7822 YQEEIAIAQENKIQLQQMGERLAKASHESKAS-EIEYKLGKVNDRWQHLLDLIAARVKKL 7880
+ ++ + ++ +LQ + L S E K++ E++ K V ++ LL+ + R
Sbjct: 1412 LENQMEVRKKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMELLEPLNER---- 1464
Query: 7881 KETLVA---VQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 7937
K L+A + Q ++++ W+ LA + N + +Q + + Q LQ++I+
Sbjct: 1465 KHNLLASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGH-NLQTVQLLIKKNQTLQKEIQ 1522
Query: 7938 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEET 7997
H + + + ++ D + + +A I+Q +L + W + + +R ++EE
Sbjct: 1523 GHQPRIDDIFERSQNIVTDSSSLSAEA----IRQRLADLKQLWGLLIEETEKRHRRLEEA 1578
Query: 7998 WRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEE----------LKKFEAFQR 8047
R Q++ D + E W+ E +Y +++E+ LKK + ++
Sbjct: 1579 HRA-QQYYFDAAEAEAWMSEQE-----------LYMMSEEKAKDEQSAVSMLKKHQILEQ 1626
Query: 8048 QVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFI 8107
V + + ++K R L ++ +S + + + D L + + + +
Sbjct: 1627 AVEDYAETVHQLSKTSRALVADSHPES-----ERISMRQSKVDKLYAGLKDLAEERRGKL 1681
Query: 8108 GQREE-FETAR--DSILVWLTEMDLQLTNIEHFSECDVQAKIKQ-LKAFQQEI-SLNHNK 8162
+R F+ R D + W+ E ++ + E + + +++ + F ++ ++ +
Sbjct: 1682 DERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQER 1741
Query: 8163 IEQIIAQGEQLIEKSEPLDAAIIEEELD------------------------ELRRY--- 8195
++ + ++LI DAA I E D EL ++
Sbjct: 1742 VDTVNHLADELINSGHS-DAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHD 1800
Query: 8196 CQEVFGRVERYHKKL 8210
+E+FGR++ HKKL
Sbjct: 1801 AKEIFGRIQDKHKKL 1815
Score = 124 bits (311), Expect = 4e-27
Identities = 311/1735 (17%), Positives = 655/1735 (37%), Gaps = 240/1735 (13%)
Query: 1437 DIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL-NALETS-------SSAMDMQISQIKV 1488
D K++ + H+ S + L+V K L NA+ET S A D+ + I+
Sbjct: 249 DEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDL-LEWIEQ 307
Query: 1489 TIQEIESK--LSSIVGLEEEAQSFAQFVTTGESARIKAK--------------------- 1525
TI + ++ +S+VG++++ Q+F + T + + K
Sbjct: 308 TIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKV 367
Query: 1526 --------LTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAV 1577
++ I + E L + E + L +Q+K E+ R+ + + E L+
Sbjct: 368 YMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSE 427
Query: 1578 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1637
++ S + L + E++ + I A+ + VV + +E A + Y
Sbjct: 428 NQRLVSQDNFGFD-LPAVEAATKKHEAIETDIAAYEERVQAVV---AVARELEA--ENYH 481
Query: 1638 DILRRAKERQTA-------LENLLAHWQRLE---------KELSSFLTWLERGEAKASSP 1681
DI R + LE L A QRLE +E+ + W++ + S
Sbjct: 482 DIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQ 541
Query: 1682 E---------------------MDISADRVK-VEGELQLI------------QALQNEVV 1707
+ + I A+RV+ V Q Q +++ V
Sbjct: 542 DYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVA 601
Query: 1708 SQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDER-W-RDLPQIIN-----KRINFL 1760
Y +L QL ++ ++ K E +E W R+ +I++ K + +
Sbjct: 602 HMEFCYQELCQLAAER-RARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSV 660
Query: 1761 QSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGEL 1820
++++H+ F++ + S + + E E I + + ++ + + L
Sbjct: 661 MRLLSKHRAFEDEMSGRSGHFEQAIKE----GEDMIAEEHFGSEKIRERIIYIREQWANL 716
Query: 1821 QSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA--EFLQSHA 1878
+ L K L A LH Q A+D + ++V + + ++ H
Sbjct: 717 EQLSAIRKK--RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 774
Query: 1879 SLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLK 1938
++ + R T++ ++++ S L ++ + + + G LS + K
Sbjct: 775 DVAEEIANYRPTLD---TLHEQASALPQE------------HAESPDVRGRLSGIEERYK 819
Query: 1939 IGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIE 1998
+ R +A D L L SEADA + + D+KE+ L +++ E
Sbjct: 820 EVAELTRLRKQALQDTLA---------LYKMFSEADACEL----WIDEKEQWLNNMQIPE 866
Query: 1999 ERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDR 2058
+ D E +Q R F LE E+N+ + + A+Q+ E+
Sbjct: 867 KLEDLE--------VIQHR---FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 915
Query: 2059 EINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQ 2118
+ ++L W + L+ + + + + S + E I+
Sbjct: 916 QQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTK-------VIEST 968
Query: 2119 EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKI---HSSDFSLVKTDMESTV 2175
+DL + + K+ ++DL +K L E +K+ H + + +
Sbjct: 969 QDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEIS 1028
Query: 2176 DKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-RAE 2234
D W ++ L+ N + S L D+ + W + +A ++ N L AE
Sbjct: 1029 DVWEEMKTTLK-NREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE--DMPNTLTEAE 1085
Query: 2235 ELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEV 2294
+LL + E+ +KN+ EE + K+ D+ E+ +T F+ L E+ ++
Sbjct: 1086 KLLTQHEN-IKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKM 1144
Query: 2295 AKGTLKDFTAQSTQVEKFINDIT---TWFTKVEESLMNCAQNETCE----ALKKVKDIQK 2347
+ ++ +QS ++F+ D + E L + T E A+KK +D
Sbjct: 1145 WENR-QNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMT 1203
Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
+ + + I++ E L + + + + + +H + S+ L+++
Sbjct: 1204 TMDANEEKINAVVETGRRLVSD-GNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNR 1262
Query: 2408 E-KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
+ + F + QE W A++ S +++ L +K Q + ++ + LD +
Sbjct: 1263 DLQKFLQDCQELSLWINEKMLTAQDMS--YDEARNLHSKWLKHQAFMAELASNKEWLDKI 1320
Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
+EG L + + + ++E++T ++ ++ Q L D A++ F
Sbjct: 1321 EKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCAD 1378
Query: 2527 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
L+ W+H +E + +++ G+ + + K +M ++ ++ +++L + Q LS+
Sbjct: 1379 LDKWLHGLESQIQSDDYGKDLTSV---NILLKKQQMLENQMEVRKKEIEELQSQAQALSQ 1435
Query: 2587 EGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDR 2646
EG + + T LL E+ + + + H+ ++ WV +R
Sbjct: 1436 EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ-FNRDVEDEILWVG---ER 1491
Query: 2647 LACAESTLGSKD--TLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQ 2704
+ A ST + T++ + + Q + + +++ + + + S+ I+
Sbjct: 1492 MPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR 1551
Query: 2705 TQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQP 2764
+L LK++W ++ + LE Y + + E WM +Q++ + +
Sbjct: 1552 QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAA-EAEAWMS--EQELYMMSEEKA 1608
Query: 2765 GLKEKFVLLDHLQSILSEA-EDHTRALHRLIAKSRELYEKTEDESFK-DTAQEELKTQFN 2822
++ V + IL +A ED+ +H+L SR L + ES + Q ++ +
Sbjct: 1609 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1668
Query: 2823 DIMTVAKEKMRKVEEIVKDHLMYLD-AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
+ +A+E+ K++E + L L+ V + W+ + +E + ++ D
Sbjct: 1669 GLKDLAEERRGKLDE--RHRLFQLNREVDDLEQWI-AEREVVAGSHELGQDYEHVTMLQE 1725
Query: 2882 KIKELI-DSREIGASRLSRVESLAPEV-----------------KQNTTASGCELMHTEM 2923
+ +E D+ IG R+ V LA E+ A EL+ T
Sbjct: 1726 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1785
Query: 2924 QALRADW--------------------KQWEDSVFQTQSCLENLVSQMALSEQEFSGQVA 2963
Q L A + K+ + + + Q+ +E L E +
Sbjct: 1786 QILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGT 1845
Query: 2964 QLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3018
Q+ Q E + L +A + + + E++E W + +LDA + R D
Sbjct: 1846 QVRQLQEDAARLQAAYAGD-KADDIQKRENEVLEAW---KSLLDACESRRVRLVD 1896
Score = 119 bits (299), Expect = 1e-25
Identities = 310/1823 (17%), Positives = 686/1823 (37%), Gaps = 245/1823 (13%)
Query: 3154 WKNFHSNLHQKESALENLKIQMKDFEVSAEPI-------QDWLSKTEKMVHESSNRLYDL 3206
W+ H++E AL N I+ + E A + WLS+ +++V + N +DL
Sbjct: 383 WERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD-NFGFDL 441
Query: 3207 PAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALS 3265
PA +K +++ +I YE ++ + A++L E K R + + L
Sbjct: 442 PAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLL 501
Query: 3266 NLTKEKVSRLDRIVAEHNQFS--LGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKL 3323
L + + RL+ + F L I + D M + D H + +L TL +
Sbjct: 502 ELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTL-V 560
Query: 3324 EALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQ 3383
EA + ++ E+ + + + + P I+ ++ ++ + L +++
Sbjct: 561 EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRAR 620
Query: 3384 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYS 3443
LE + W + + + + GW+ E L+ S+ +L +L K + +E+ S
Sbjct: 621 LEESRRLWKFFWE-MAEEEGWIREKEKILS-SDDYGKDLTSVMRLLSKHRAFEDEMSGRS 678
Query: 3444 SLLETIEVKGAGM--TEHYVTQL---ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ 3498
E +G M EH+ ++ + ++E++ +++ + + E+ LHQ +Q
Sbjct: 679 GHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQ-FQ 737
Query: 3499 RDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRED 3558
D + W+ + K+ S + D ++ ++ ++ +++ A + L++ LH +
Sbjct: 738 ADADDIDAWM-LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDT-LHEQAS 795
Query: 3559 VIP-------------SGIPQAEDRALESLR----------------------------- 3576
+P SGI + E R
Sbjct: 796 ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEK 855
Query: 3577 -------------QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQV-------DEWLKT 3616
+D + QHR + NN +++ ++ Q +Q+ ++ +K
Sbjct: 856 EQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 915
Query: 3617 AEEKVSPRTRRQSNRATKE--------------IQLHQMKKWHEEVTAYRDEVEEVG--- 3659
++K++ R + ++ ++ ++ K W E T + +++G
Sbjct: 916 QQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDL 975
Query: 3660 -----------ARAQEILDESHVNSRMGCQATQLTSRY----QALLLQVLEQIKFLEEEI 3704
++++ S + +A +L S + QA+L ++ E EE
Sbjct: 976 AGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMK 1035
Query: 3705 QSLEESESSLSSYS---------DWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL-EVLL 3754
+L+ E+SL S D + S + D +T+ +KL T E +
Sbjct: 1036 TTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIK 1095
Query: 3755 KDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKG 3814
+++ + R+ GE + + + LR+ + EL L +
Sbjct: 1096 NEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS 1155
Query: 3815 LHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVK 3874
H ++F K ++ + +L E P L +A + K + T+ ++E +
Sbjct: 1156 -HAYQQFLRDTKQAEAFLNNQEYVLAHTEMP-TTLEGAEAAIKKQEDFMTTMDANEEKIN 1213
Query: 3875 SVREKGEALLELVQDVTL-KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQE 3933
+V E G LV D + D+I + D +E L ++KD+ D LQ+
Sbjct: 1214 AVVETGR---RLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD 1270
Query: 3934 VEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQ 3993
++ L ++ +++ + + + H+A M E+A ++ L+ ++ +G LI +
Sbjct: 1271 CQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE 1330
Query: 3994 CADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLS 4053
+ + + V L G + + ST Q Q L + K + WL
Sbjct: 1331 -----KPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL-FDANKAELFTQSCADLDKWLH 1384
Query: 4054 AVQPDLEPSP--QPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDI 4111
++ ++ + S +K+ + E + ++ L S + K+T ++
Sbjct: 1385 GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKST-DEV 1443
Query: 4112 QQTEQTIEQKLVQAQNLTQGWEEIKH---LKSELWIYLQDADQQLQNMKRR--------H 4160
T++ K ++ L + E KH E+ + +D + ++ + R H
Sbjct: 1444 DSKRLTVQTKFME---LLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDH 1500
Query: 4161 SELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINH----LND 4216
L Q ++ + + K++Q Q ++ I E+ + S + I L
Sbjct: 1501 GH-NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQ 1559
Query: 4217 QWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLE 4276
W L ++ + EE + + Y D E+ D +S L+
Sbjct: 1560 LWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1619
Query: 4277 ALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKI 4336
+ L A+++ + L + ++ + + E + + S +++ + L+DL + +
Sbjct: 1620 KHQILEQAVEDYAETVHQLSKTSRALVADSH-PESERISMRQSKVDKLYAGLKDLAEER- 1677
Query: 4337 QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA 4396
+ + L + +L +W IAE + ++ Q+ +H+
Sbjct: 1678 RGKLDERHRLFQLNREVDDLEQW-------IAEREVVAGSHELGQD--YEHVT------- 1721
Query: 4397 KQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKA----- 4451
+L+ ++ R ++G + + + + + + + + LN+A
Sbjct: 1722 ---MLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLL 1778
Query: 4452 --LSEKTQFLMAVFQATSQIQQHERKIMF---REHICLLPDDVSKQVKTCKSAQASLKTY 4506
+ +TQ L A ++ H+ K +F ++ LP+++ + T ++ Q T+
Sbjct: 1779 ELIDTRTQILAASYELHK--FYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTF 1836
Query: 4507 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
++++ L Q R+L ++ + + K ++Q + VL+ L E R
Sbjct: 1837 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR---RVR 1893
Query: 4567 FKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTG 4626
+ DK + D++ + E +++ Q E R
Sbjct: 1894 LVDTGDKFRFFSMVRDLMLWME------------------DVIRQIEAQEK-----PRDV 1930
Query: 4627 QTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYAS------LI 4680
++ +N +H + +++A F + L K ++LARK YAS L+
Sbjct: 1931 SSVELLMN--NHQGIKAEIDARNDSFTTCIELGK--------SLLARKHYASEEIKEKLL 1980
Query: 4681 ELTTQSLSELE---------AQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD 4731
+LT + ++ L + + D +V EA L E+ + V+
Sbjct: 1981 QLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVE 2040
Query: 4732 ELNQKKEGFRSTGQPW-QPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4790
+L ++ E F + W + L +T L+ + +Q + + + K+ ++
Sbjct: 2041 KLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEA 2100
Query: 4791 ERQLKSVKEEQSKVNEETLPAEE 4813
E Q + + +V++ LPAE+
Sbjct: 2101 ESQQQWDTSKGEQVSQNGLPAEQ 2123
Score = 117 bits (294), Expect = 4e-25
Identities = 315/1595 (19%), Positives = 599/1595 (37%), Gaps = 234/1595 (14%)
Query: 7163 LEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNN 7222
++A+ V+ + + D+ + E+ ++K+ S+ + LL E + T+ +N R
Sbjct: 267 MKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL--------EWIEQTIIILNNR--- 315
Query: 7223 LLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR---TNELLKAATNKDIADDEV 7279
+ A L + LQ + Y+ K T + + T + A N+ +
Sbjct: 316 ---KFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE 372
Query: 7280 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7339
I D N + L + HE L+ ++ I+ ++L + A
Sbjct: 373 GKLISDINKAWERLEKAE------HERELALRNEL-------IRQEKLEQLARRFDRKAA 419
Query: 7340 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQ 7399
+ + S ++ + F L A+EA + E I +D++ +ER++ +
Sbjct: 420 MRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAI--------ETDIAAYEERVQAVV-- 469
Query: 7400 MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ 7459
++A +L+ N + + R N+ R W + R +L+ L +
Sbjct: 470 -----AVARELEAENYHDIK-----RITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 519
Query: 7460 TFLEKCET--WMEFLVQTEQKLAVEISGNYQHLLEQQ---RAHELFQAEMFSRQQILHSI 7514
F E WM+ E K+ V +HLL + + H L +A++ + + + +
Sbjct: 520 IFQEMLYIMDWMD-----EMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGV 574
Query: 7515 IIDGQRLLEQGQ---VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 7571
Q+ G+ D ++ + +Q + + A +RR ++ R W+ + EM
Sbjct: 575 NASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEM 634
Query: 7572 AEKLRKWLVEVSYLPMSG-----LGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE 7626
AE+ W+ E + S L SV L + R DE+ + G + ++
Sbjct: 635 AEE-EGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRS-------GHFEQAIK 686
Query: 7627 AGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL--AFLLKDWEKCEKGIAD 7684
G+ ++ G+E ++ + I+E+W + +KK+L A LL ++ AD
Sbjct: 687 EGEDMIAEEHFGSEK-IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQ----ADAD 741
Query: 7685 SLEKLRTFKKKLSQSLPDHHEELHAEQM--RCKELENAVGSWTDDLTQLSLLKDTL-SAY 7741
++ K+ S H+E + + + K++ + ++ L L L +
Sbjct: 742 DIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEH 801
Query: 7742 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK------ELCEW 7795
+ D+ R+ ++ +++E+ LR+Q + + L + +FSE + E +W
Sbjct: 802 AESPDV---RGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQW 858
Query: 7796 LTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEI 7855
L M+ +I+ E L+ + + + + Q+ +L + H S+ EI
Sbjct: 859 LNNMQIPEKLEDLEVIQHRFESLEPEMNNQAS----RVAVVNQIARQLMHSGHPSE-KEI 913
Query: 7856 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7915
+ + K+N RW +L+ + L L ++Q + ++W+ K V +
Sbjct: 914 KAQQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIRE------KTKVIE 966
Query: 7916 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7975
S ++++ L LQR + TG+ L E L D A E + QA
Sbjct: 967 S--TQDLGNDLAGVMALQRKL----TGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1020
Query: 7976 LDRR------WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSG 8029
L R W + R + E +L Q+FL D F+ WL ++ A
Sbjct: 1021 LSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAIASEDMPN 1079
Query: 8030 VIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS-LKQMVHEGNQR 8088
+ T A++ L + E + ++ + + + + + +TD+ L+Q + +
Sbjct: 1080 TL-TEAEKLLTQHENIKNEIDNYEEDYQKM-RDMGEMVTQGQTDAQYMFLRQRLQALDTG 1137
Query: 8089 WDNLQK------RVTSILRRLKHFIG---QREEFETARDSILVWLTEMDLQLTNIEHFSE 8139
W+ L K + S + F+ Q E F ++ +L TEM L E
Sbjct: 1138 WNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH-TEMPTTLEGAE---- 1192
Query: 8140 CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV 8199
A IK+ + F + N KI ++ G +L+ +++ I+E++D +
Sbjct: 1193 ----AAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGN-INSDRIQEKVDSI------- 1240
Query: 8200 FGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL 8259
DD H +RE E L D +R L Q LSL
Sbjct: 1241 -----------------DDRHR-KNRETASELLMRLKD----NRDLQKFL--QDCQELSL 1276
Query: 8260 SLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES------AMSRALPSEDE----- 8308
+ + + + + D YD +R+L S A L S E
Sbjct: 1277 WINEKMLTAQ----------------DMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI 1320
Query: 8309 ---------EGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIR-S 8358
E + + GL LES + + L D+ T++
Sbjct: 1321 EKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLD 1380
Query: 8359 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL---KEEEESLPGFVNLHSTETQTA 8415
K G E Y K L + + + LE+++ K+E E L S E ++
Sbjct: 1381 KWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKST 1440
Query: 8416 GVIDRWELLQAQALSKEL-----RMKQNL---QKWQQFNSDLNSIWAWLGDTEEELEQLQ 8467
+D + L Q EL K NL ++ QFN D+ W+G E +
Sbjct: 1441 DEVDS-KRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVG---ERMPLAT 1496
Query: 8468 RLELSTDIQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKESRDLQDRLSQ 8526
+ ++QT++L IKK + LQK + H+ I T + S + ++ RL+
Sbjct: 1497 STDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLAD 1556
Query: 8527 MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAE 8586
+ W + E+ L++A Q + + + M E +E D
Sbjct: 1557 LKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS 1616
Query: 8587 ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLV---NAEGTDCLEAKEKVHVIGNRLK 8643
+L+ H QI + +E + + LV + E + KV + LK
Sbjct: 1617 MLKKH-----QILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLK 1671
Query: 8644 LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 8678
L +E + E +L ++ DL W + E+
Sbjct: 1672 DLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV 1706
Score = 116 bits (290), Expect = 1e-24
Identities = 371/1932 (19%), Positives = 735/1932 (38%), Gaps = 250/1932 (12%)
Query: 5937 LGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP 5996
+ D+ ++WE L+ E++ L L RQ+K + + K E LSE+
Sbjct: 376 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR----- 430
Query: 5997 ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMST 6056
L+ QD + EA + A+++ + ER+
Sbjct: 431 --------------LVSQDNFG---------FDLPAVEAATKKHEAIETDIAAYEERVQA 467
Query: 6057 IRMKASGKRQLLEEKLND-QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKE 6115
+ A R+L E +D + R++ ++ + + L L + + L+ L K
Sbjct: 468 VVAVA---RELEAENYHDIKRITARKDNVIRLW----EYLLELLRARRQRLEMNLGLQKI 520
Query: 6116 PMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL-KG 6174
+M +MD + E KV+ LS+ D + L G L K
Sbjct: 521 FQEM-LYIMDWMD-----EMKVLVLSQ-----------------DYGKHLLGVEDLLQKH 557
Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGV-------QEWLAQARTTWTQQR 6227
+L+E + +++ + +K +D + P V E+ Q +R
Sbjct: 558 TLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAER 617
Query: 6228 QSSLQQQKELEQ---ELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGM 6284
++ L++ + L + E+AE++ +R E+IL S+ + D +LS+
Sbjct: 618 RARLEESRRLWKFFWEMAEEEGWIREK----EKIL---SSDDYGKDLTSVMRLLSKHRAF 670
Query: 6285 EGEKSSA----EDQMRMKWESLHQEFSTKQKLLQNVLE-QEQ----EQVLYSRPNRLLSG 6335
E E S E ++ + + +E +K+ + ++ +EQ EQ+ R RL
Sbjct: 671 EDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 730
Query: 6336 VPLYKGDVPTQDKSA----VTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6391
L++ D A + ++ + +E S+QS K + + E Y
Sbjct: 731 SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPT---- 786
Query: 6392 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6451
LD + E+ A+AL E E+ + I+E +E+ + L QA
Sbjct: 787 --LDTLHEQ---ASALPQEHAESPDVRGRL--SGIEERYKEVAELTRLRKQA-------- 831
Query: 6452 DVIEDTLGCLLGRLSLLDSVVNQRCHQ-MKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
++DTL L S D+ C + E+ Q + N Q K+ + +++ L+
Sbjct: 832 --LQDTLA-LYKMFSEADA-----CELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEP 883
Query: 6511 LANVFEQPVAEQIEAIQQ-AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDE 6569
N A ++ + Q A + E+K + DKL +EL + D
Sbjct: 884 EMN----NQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL--VDRKKDA 937
Query: 6570 LMMIIGSRRSGLNQNLTL-----KSQYERALQDLADLLE---TGQEKMAGDQKIIVSSKE 6621
L+ + + L N T K++ + QDL + L Q K+ G ++ +V+ +
Sbjct: 938 LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 997
Query: 6622 EIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRG 6681
++ L KE + H + + ++ + ++ + LK
Sbjct: 998 KLSDL---QKEAEKLESEHPDQAQAILSRLAEIS---------DVWEEMKTTLKNREASL 1045
Query: 6682 VELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNE 6741
E + + LD+ Q LSR + S L E + +T ++++K+ ++
Sbjct: 1046 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEK-----LLTQHENIKNEIDN 1100
Query: 6742 YQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
Y+ ++ D G+ + + + L +L L W N++ K + +L
Sbjct: 1101 YEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW----NELHKMWENRQNLLSQSH 1156
Query: 6799 RYQSESADLIHWLQSAKDRLEFWTQQSVTV-----PQELEMVRDHLNAFLEFSKEVDAQS 6853
YQ +L+ K F Q + P LE + +F +DA
Sbjct: 1157 AYQQ-------FLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANE 1209
Query: 6854 SLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQ--MDKLP 6911
++V+ TG +L+ +++ ++ ++ ID + N E L +L+ D
Sbjct: 1210 EKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRK---NRETASELLMRLKDNRDLQK 1266
Query: 6912 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 6971
E+ WI+ E ++ + + + + +H K++ F ++ + +D +
Sbjct: 1267 FLQDCQELSLWIN--EKMLTAQDMSYDEA---RNLHSKWLKHQAFMAELASNKEWLDKIE 1321
Query: 6972 QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
+ +Q+ S+ E++ K E+L ++K W++L+ K Q L ++ + +
Sbjct: 1322 KEGMQLISEKPETEAVVK----EKLTGLHKMWEVLESTTQTKAQRLFDANKA-ELFTQSC 1376
Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 7091
L W E +++ D SV LK Q LE+ ++ ++KE+E+++ AL Q
Sbjct: 1377 ADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQE 1436
Query: 7092 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL-MEAR 7150
K S+ + + R QT ++ L ++L H+ D + L + R
Sbjct: 1437 GK---STDEVDSKRLTVQT--KFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGER 1491
Query: 7151 YSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLT 7210
L+ +L+ VQ+ + Q LQ +++ + + + ++ + E +
Sbjct: 1492 MPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR 1551
Query: 7211 NTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAAT 7270
L ++ W L+EE ++ + + + Q Y D ++ A +Q+ L +
Sbjct: 1552 QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQE-------LYMMS 1604
Query: 7271 NKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS 7330
+ D++ A + + +L+ V+D +H+L + + V A S +S+++S+
Sbjct: 1605 EEKAKDEQSAVSMLKKHQILE--QAVEDYAETVHQLSKTSRALV---ADSHPESERISMR 1659
Query: 7331 QHLCALEQALCKQQTSLQAGVLDYE----TFAKSLEALEAWIVEAEEIL----QGQDPSH 7382
Q A K + G LD + ++ LE WI E E + GQD H
Sbjct: 1660 QSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEH 1719
Query: 7383 SSDLSTIQERMEELKGQMLKFSSMAPD-----LDRLNELGYRLPLNDKEIKRMQNLNRHW 7437
++ +QER E D D L G+ E K LN W
Sbjct: 1720 ---VTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWK--DGLNEAW 1774
Query: 7438 SLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-QRA 7496
+ + R L + H+ + + E + +Q + K E G Q+ +E QR
Sbjct: 1775 ADLLELIDTRTQILAASYELHKFYHDAKEIFGR--IQDKHKKLPEELGRDQNTVETLQRM 1832
Query: 7497 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR- 7555
H F+ ++ + + + D RL D D+ + + W+ ++ + RR
Sbjct: 1833 HTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRV 1892
Query: 7556 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7615
++D+ + R+ M L W+ +V + P + L + Q +
Sbjct: 1893 RLVDTGDK--FRFFSMVRDLMLWMEDV--IRQIEAQEKPRDVSSVELLMNNHQGIKAEID 1948
Query: 7616 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7675
+ S+ +E GK LL +E ++ +L ++ EK K + E++ + L +L+
Sbjct: 1949 ARNDSFTTCIELGKSLLARKHYASE-EIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVH 2007
Query: 7676 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7735
+ L S+ + +E+ R + E + +W + + L L
Sbjct: 2008 QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLT 2067
Query: 7736 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7795
E +E+ ++Q EE R++ SE+ + +W
Sbjct: 2068 TL--------------ELLEVRRQQEEE-------ERKRRPPSPEPSTKVSEEAESQQQW 2106
Query: 7796 LTQMESKVSQNG 7807
T +VSQNG
Sbjct: 2107 DTSKGEQVSQNG 2118
Score = 112 bits (279), Expect = 2e-23
Identities = 323/1717 (18%), Positives = 664/1717 (38%), Gaps = 220/1717 (12%)
Query: 6472 VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII-----LQKLANVFEQPVAEQIEAI 6526
+N ++ + + I+++ +++KVL S K+++ LQK V E + Q E +
Sbjct: 513 MNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLV-EADIGIQAERV 571
Query: 6527 QQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLT 6586
+ ++F G K Q ++ ++ Y EL + RR+ L ++
Sbjct: 572 RGVNASAQKFATD-----GEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRR 626
Query: 6587 LKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY---FQGLESHM-- 6641
L + ++ + E + + D ++S + +LL KH+ + G H
Sbjct: 627 LWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS---VMRLLSKHRAFEDEMSGRSGHFEQ 683
Query: 6642 -------ILTETLF--RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWS 6692
++ E F KI + Q+ + Q SA+ K KR E + + +
Sbjct: 684 AIKEGEDMIAEEHFGSEKIRERIIYIREQWAN--LEQLSAIRK---KRLEEASLLHQFQA 738
Query: 6693 HLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDD 6752
D+ + L++V SS VG E + L+ + ++ + + Y+P L + +
Sbjct: 739 DADDIDAWMLDILKIVSSS--DVGHDEYSTQSLVKK---HKDVAEEIANYRPTLDTLHEQ 793
Query: 6753 GKRLLISISCS-DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 6811
L + S D+ +L+ + E + K EL RL + + ++ +
Sbjct: 794 ASALPQEHAESPDVRGRLSGIEERY-----KEVAELTRLR-------KQALQDTLALYKM 841
Query: 6812 QSAKDRLEFWTQQ------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 6865
S D E W + ++ +P++LE + + F E++ Q+S + V Q
Sbjct: 842 FSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ 901
Query: 6866 LLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA-ISEVMSWIS 6924
L+ ++++ +++++W+ + ++ L L + + H +E SWI
Sbjct: 902 LMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL--LSALSIQNYHLECNETKSWIR 959
Query: 6925 LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 6984
VI+ +D + G A+ L + + I K S LQ ++ +ES
Sbjct: 960 EKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKL--------SDLQKEAEKLES 1011
Query: 6985 KRSDKTD-FAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 7043
+ D+ +L ++ W+ ++ + + L G ++ ++ ++W +
Sbjct: 1012 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASL-GEASKLQQFLRDLDDFQSWLSRTQT 1070
Query: 7044 RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 7103
+ + + L +++++ I E++ +K+ G + Q + + +
Sbjct: 1071 AIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQR 1130
Query: 7104 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL---LT 7160
L+ L W L H + + + L S + + ++L Y L+ + L
Sbjct: 1131 LQALDTGWNEL-HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLE 1189
Query: 7161 GSLEAVQVQVDNLQNLQDDLEKQE------RSLQKFGSITNQLLKEC-------HPPVTE 7207
G+ A++ Q D + + + EK R L G+I + ++E H E
Sbjct: 1190 GAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE 1249
Query: 7208 TLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL-- 7265
T + L + ++ N L++ + Q L LW K + Q S + + + L
Sbjct: 1250 TASELL--MRLKDNRDLQKFLQDCQE----LSLWINEKMLTAQDMSYDEARNLHSKWLKH 1303
Query: 7266 ----LKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7321
+ A+NK+ D +Q ++ + VK+ L LH++ E L+ A
Sbjct: 1304 QAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL 1363
Query: 7322 IQSDQLSLSQHLCA-LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
+++ L CA L++ L ++ +Q+ + + K L ++ +++ +++L+ Q
Sbjct: 1364 FDANKAELFTQSCADLDKWLHGLESQIQS-----DDYGKDLTSVNI-LLKKQQMLENQ-- 1415
Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLN-RHWSL 7439
+ ++ +EEL+ Q S D ++ RL + K ++ ++ LN R +L
Sbjct: 1416 -----MEVRKKEIEELQSQAQALSQEGKSTDEVDSK--RLTVQTKFMELLEPLNERKHNL 1468
Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ----R 7495
++S+ +F++ +E W+ +++ + S ++ H L+ +
Sbjct: 1469 LASKEIHQFNR----------DVEDEILWVG------ERMPLATSTDHGHNLQTVQLLIK 1512
Query: 7496 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7555
++ Q E+ Q + I Q ++ + +L L W +I ++R
Sbjct: 1513 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1572
Query: 7556 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7615
++ R Q Y + AE W+ E MS ++A+ V +K +
Sbjct: 1573 RRLEEAHRAQQYYFDAAEA-EAWMSEQELYMMSE--------EKAKDEQSAVSMLKKHQI 1623
Query: 7616 RQQG--SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 7673
+Q Y TV LS S +A +A+ + + SMR + + KL LK
Sbjct: 1624 LEQAVEDYAETVHQ-----LSKTS------RALVADSHPESERISMR-QSKVDKLYAGLK 1671
Query: 7674 DWEKCEKGIADSLEKLRTFKKKL---------------SQSLPDHHEELHAEQMRCKELE 7718
D + +G D +L +++ S L +E + Q R +E
Sbjct: 1672 DLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFA 1731
Query: 7719 NAVGSWTDD-LTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGE 7777
G+ + + ++ L D L D + + E + L W +L + R Q +
Sbjct: 1732 RDTGNIGQERVDTVNHLADEL-INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAA 1790
Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIEEMIEKLKKDYQEEIAIAQENKIQ 7835
E F KE+ + K+ + D E ++++ ++ +I Q
Sbjct: 1791 SY-ELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQ 1849
Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMS 7895
LQ+ RL A KA +I+ + +V + W+ LLD +R +L +T + +
Sbjct: 1850 LQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VR 1908
Query: 7896 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7955
L W+ + ++ +S E+ +N Q ++ +I+ + + + L + LL
Sbjct: 1909 DLMLWMEDVIRQIEAQEKPRDVSSVEL--LMNNHQGIKAEIDARNDSFTTCIELGKSLL- 1965
Query: 7956 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLW-------QKFLDDY 8008
A+ + + + E K E+ W W +F D
Sbjct: 1966 -----------ARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWE-WLRLILEVHQFSRDA 2013
Query: 8009 SRFEDWLKSSERTAAFPSSSGVIYTVAKEE--LKKFEAFQRQVH---------ECLTQLE 8057
S E WL E + SS + +V + E +K+ EAF++ E LT LE
Sbjct: 2014 SVAEAWLLGQE---PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE 2070
Query: 8058 L--INKQYRRLARENRTDSACSLKQMVH--EGNQRWD 8090
L + +Q R+ R S ++ E Q+WD
Sbjct: 2071 LLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWD 2107
Score = 99.8 bits (247), Expect = 1e-19
Identities = 334/1812 (18%), Positives = 714/1812 (39%), Gaps = 232/1812 (12%)
Query: 3684 SRYQALLLQVLEQIKFLEEEIQS---LEESESSLSSYSDWYGST-----HKNFKNVATKI 3735
S+ +AL ++ K L+ I++ +E+ ES S +W T ++ F N +
Sbjct: 265 SKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGV 324
Query: 3736 DKVDTVMMGKKLKTLEVLLKDMEKGHS-----LLKSAREKGERAVKYLEEGEA------- 3783
+ + +T+E K EKG+ ++S + V EG+
Sbjct: 325 QQ--QLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKA 382
Query: 3784 -ERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3842
ERL K H+ +EL +R E + EK LA+ F K W++E Q ++
Sbjct: 383 WERLEKAEHE-----RELA--LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS-Q 434
Query: 3843 EEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSV----RE-KGEALLELVQDVTLKDKID 3897
+ +L +A K+++++ + ++E V++V RE + E ++ + KD +
Sbjct: 435 DNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVI 494
Query: 3898 QLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLE 3957
+L E++ L + + N LQ++ + +L + D ++ +
Sbjct: 495 RLW-----------EYLLELLRARRQRLEMNLGLQKIFQEMLYIM------DWMDEMKVL 537
Query: 3958 TITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQ------ 4011
++Q H + G ED L TL+ + +QA+ + V+A Q
Sbjct: 538 VLSQDYGKH------LLGVEDLLQK-----HTLV-EADIGIQAERVRGVNASAQKFATDG 585
Query: 4012 -GTKDSYSAICSTAQRMYQSLEHEL-QKHVSRQDTLQQCQA-----WLSAVQPDLEPSPQ 4064
G K + + EL Q R+ L++ + W A + +
Sbjct: 586 EGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKE 645
Query: 4065 PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE---QTIEQK 4121
LS + K + L + R + D + ++K I + + I ++
Sbjct: 646 KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRER 705
Query: 4122 LVQAQNLTQGWEEIKHLKSE-------LWIYLQDAD----------QQLQNMKRRHSELE 4164
++ + E++ ++ + L + DAD + + + H E
Sbjct: 706 IIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYS 765
Query: 4165 LNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKE-ESPEHK-EINHLNDQWLDLC 4222
Q++V + KD +++ + + +++T+ E+ + L ++ ESP+ + ++ + +++ ++
Sbjct: 766 ---TQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVA 822
Query: 4223 RQSNNLCLQREEDLQRTRDYHDCMN---VVEVFLEKFTTEWDNLAR-----SDAESTAVH 4274
L R++ LQ T + + E+++++ +W N + D E
Sbjct: 823 E----LTRLRKQALQDTLALYKMFSEADACELWIDE-KEQWLNNMQIPEKLEDLEVIQHR 877
Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
E+L+ + Q + A+ + Q + + H ++ +K Q L RW Q +L+ R
Sbjct: 878 FESLEP-EMNNQASRVAVVN---QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDR 933
Query: 4335 KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE- 4393
K ++ L N E W E+ I Q D+A + + E
Sbjct: 934 KKDALLSALSIQNY-HLECNETKSWIREKTKVIEST--QDLGNDLAGVMALQRKLTGMER 990
Query: 4394 -LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKAL 4452
L A + L L K+A+++ ++ ++ Q I L++ + + R L +A
Sbjct: 991 DLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEISDVWEEMKTTLKNREASLGEA- 1048
Query: 4453 SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTG 4512
S+ QFL + S + + + I + L + K + ++ + + Y+ +
Sbjct: 1049 SKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTE-AEKLLTQHENIKNEIDNYEEDYQK 1107
Query: 4513 LWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH----FK 4568
+ G + + T+ + + +LQ L + ++ + H++ E +NL+S+ H F
Sbjct: 1108 MRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-----HKMWENRQNLLSQSHAYQQFL 1162
Query: 4569 EDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQ 4627
D +A +L + ++ E+ E +E + K ++ + E + + TG+
Sbjct: 1163 RDTKQAEAFLNNQEYVLAHTEMPTTLEGAE--AAIKKQEDFMTTMDANEEKINAVVETGR 1220
Query: 4628 TILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSL 4687
++ N ++ + EK++++ + K + +L R + ++ Q
Sbjct: 1221 RLVSDGN-INSDRIQEKVDSIDDRHR--------KNRETASELLMRLKDNRDLQKFLQDC 1271
Query: 4688 SELEAQFLRMSKVPTDLAVEEALSLQDGC---RAILDEVAGLGEAVDELNQKKEGFRSTG 4744
EL D++ +EA +L +A + E+A E +D++ +KEG +
Sbjct: 1272 QELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI--EKEGMQLIS 1329
Query: 4745 QPWQPD-----KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKE 4799
+ + + K+ L ++ L+ T+ + L D A + + C L++ L ++
Sbjct: 1330 EKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGLES 1388
Query: 4800 E--QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE-KARH 4856
+ ++ LK L ++ V K+ +E+L L+ E K+
Sbjct: 1389 QIQSDDYGKDLTSVNILLKKQQMLENQME----VRKK---EIEELQSQAQALSQEGKSTD 1441
Query: 4857 QIQSWQGELKLLTSAIGETVTECESRMVQSID---FQTEMSRSLDWLRRVKAELSGPVYL 4913
++ S + ++ + E + E + ++ S + F ++ + W+ + L+
Sbjct: 1442 EVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGE-RMPLATSTDH 1500
Query: 4914 DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSEL 4973
NLQ +Q I+K Q Q+E+Q ++ + + + T + L + + LA+L +L
Sbjct: 1501 GHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQL 1560
Query: 4974 DGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLK 5033
G + E R L E + + Q+YY A W+ + + + D +SA LK
Sbjct: 1561 WGLLIEETEKRHRRLEEAH-RAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1619
Query: 5034 SHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKED-----LEQKVASLELRSQRMSRD 5088
H E E +H L T L+ + E + KV L + ++ +
Sbjct: 1620 KHQ---ILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEE 1676
Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKAL 5148
++D R +Q RE ++D E+ ++E ++ + SHE + EH +
Sbjct: 1677 RRGKLDERHRL------FQLNRE-----VDDLEQWIAEREVV--AGSHELGQDY-EHVTM 1722
Query: 5149 V---------SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVA 5199
+ N E++ + A +L +G+ + AT++ + + W L +
Sbjct: 1723 LQERFREFARDTGNIGQERVDTVNHLADELINSGH-SDAATIAEWKDGLNEAWADLLELI 1781
Query: 5200 QDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5259
+ +IL A E F + K+ I KLP + E TL H TF
Sbjct: 1782 DTRTQILA-ASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVE--TLQRMHTTFEH 1838
Query: 5260 ELEQQQSALGMLRQQTLSMLQ-----DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTN 5314
+++ + + L Q+ + LQ D A E +++ ++ D C + + ++
Sbjct: 1839 DIQALGTQVRQL-QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDT 1897
Query: 5315 GKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-ATNHRQN 5373
G D+ + + + W+++ +I+AQ + + E N+ Q
Sbjct: 1898 G--------DKFRFFSMVRDLMLWMEDVIR-------QIEAQEKPRDVSSVELLMNNHQG 1942
Query: 5374 IEKMAEEQKEKY 5385
I+ + + + +
Sbjct: 1943 IKAEIDARNDSF 1954
Score = 96.7 bits (239), Expect = 9e-19
Identities = 320/1743 (18%), Positives = 671/1743 (38%), Gaps = 239/1743 (13%)
Query: 3481 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQ------YSVLEGDAHTHETTLRD 3534
+ + + EKL +L + + R E WL + Q + Q +E HE D
Sbjct: 398 RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETD 457
Query: 3535 L----QELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
+ + +Q A + L H D+ I +D + W+ Y L R
Sbjct: 458 IAAYEERVQAVVAVARELEAENYH---DI--KRITARKDNVIRL----WE-YLLELLRAR 507
Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKE-IQLHQMKKWHEEVT 3649
Q + L+ + Q+ + +W+ + V + + ++ +Q H + + ++
Sbjct: 508 RQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVE--ADIG 565
Query: 3650 AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEE 3709
+ V V A AQ+ + C + R + E + E LEE
Sbjct: 566 IQAERVRGVNASAQKFATDG--EGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEE 623
Query: 3710 SESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSARE 3769
S + W + + + KI D GK L ++ LL +
Sbjct: 624 SRRLWKFF--WEMAEEEGWIREKEKILSSDD--YGKDLTSVMRLLSKHRAFEDEMSGRSG 679
Query: 3770 KGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
E+A+K E E + E H E+++E +R++ LE+ + K+ ++ L
Sbjct: 680 HFEQAIK-----EGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH 734
Query: 3830 QWIAEYQEI---------LHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880
Q+ A+ +I + + + Y ++ + K+K + + + ++ P++ ++ E+
Sbjct: 735 QFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA 794
Query: 3881 EAL-LELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSE------LQE 3933
AL E + ++ ++ ++ Y+++ + + +L+ + ++ ++ + E
Sbjct: 795 SALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDE 854
Query: 3934 VEKWL--LQMSGRL------------VAPDLLETSS----LETITQQLAHHKAMME-EIA 3974
E+WL +Q+ +L + P++ +S + I +QL H E EI
Sbjct: 855 KEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIK 914
Query: 3975 GFEDRLNNLQMKGDTLIGQCADHLQAKLK-QNVHAHLQGTK----DSYSAICST------ 4023
+D+LN + L+ + D L + L QN H TK + I ST
Sbjct: 915 AQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGND 974
Query: 4024 ------AQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV- 4076
QR +E +L ++ LQ+ L + PD Q LSR I V
Sbjct: 975 LAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPD---QAQAILSRLAEISDVW 1031
Query: 4077 -------KHFRALQEQARTYLDLLCSMCD----LSNASVKTTAKDIQQTEQTIEQKLVQA 4125
K+ A +A L + D LS ++D+ T E+ L Q
Sbjct: 1032 EEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQH 1091
Query: 4126 QNL---------------------TQG--------------------------WEEIKHL 4138
+N+ TQG WE ++L
Sbjct: 1092 ENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNL 1151
Query: 4139 KSELWIYLQ------DADQQLQNMK--RRHSELELNI--AQNMVSQVKDFVKKLQSKQAS 4188
S+ Y Q A+ L N + H+E+ + A+ + + +DF+ + + +
Sbjct: 1152 LSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEK 1211
Query: 4189 VNTIIEKVNKLTKK---EESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDC 4245
+N ++E +L ++++ ++D+ ++ L ++ +++ + DC
Sbjct: 1212 INAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDC 1271
Query: 4246 MNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLAL--ALQERKYAIEDLKDQKQKMI 4303
+ EK T D S E+ +H + LK A L K ++ ++ + ++I
Sbjct: 1272 QELSLWINEKMLTAQD---MSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLI 1328
Query: 4304 EHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ 4363
+ + +VKE+ + L + W LE + K Q + + + + +L +W
Sbjct: 1329 SE-KPETEAVVKEKLTGLHKMWEVLESTTQTKAQ-RLFDANKAELFTQSCADLDKWLHGL 1386
Query: 4364 QPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVI 4423
+ I ++ LL + +++E ++ ++ L A + ++ G + +V
Sbjct: 1387 ESQI-QSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDEVD 1444
Query: 4424 QKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHIC 4483
K L+ + L L RK+ A E QF V + + +H
Sbjct: 1445 SKRLTVQTKFMELLEPL--NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1502
Query: 4484 LLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVY 4543
L V +K ++ Q ++ +Q + ++ + + ++ + + + +L +L+ ++
Sbjct: 1503 NL-QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLW 1561
Query: 4544 DSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLA 4603
++++ R + LE+ +++++ D +A W+ + ++ E +E S + + L
Sbjct: 1562 GLLIEETEKRHRRLEEAHRAQQYY-FDAAEAEAWMSEQELYMMSEEKAKDEQSAV-SMLK 1619
Query: 4604 KYQNILEQSPE-YENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
K+Q ILEQ+ E Y + L +T + ++ + + +S + + + + + + LA+++
Sbjct: 1620 KHQ-ILEQAVEDYAETVHQLSKTSRALVAD-SHPESERISMRQSKVDKLYAGLKDLAEER 1677
Query: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAV----EEALSLQDGCRA 4718
K+ E L +L + + +LE V + E LQ+ R
Sbjct: 1678 RGKLDER-------HRLFQL-NREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFRE 1729
Query: 4719 ILDEVAGLG-EAVDELNQKKEGFRSTGQ-------PWQPDKMLHLVTLYHRLKRQTEQRV 4770
+ +G E VD +N + ++G W+ L + +T Q +
Sbjct: 1730 FARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT-QIL 1788
Query: 4771 SLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGI 4830
+ + Y + +++ +++ + K + EE + + E +M+ + +Q G
Sbjct: 1789 AASYELHKFYHDAKEIFGRIQDKHKKLPEE---LGRDQNTVETLQRMHTTFEHDIQALGT 1845
Query: 4831 VLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4890
++++ ED A A +KA IQ + E + A + CESR V+ +D
Sbjct: 1846 QVRQLQ---EDAARLQAAYAGDKA-DDIQKRENE---VLEAWKSLLDACESRRVRLVDTG 1898
Query: 4891 TE-----MSRSL-----DWLRRVKA-----ELSGPVYLDLNLQDIQEEIRKIQIHQEEVQ 4935
+ M R L D +R+++A ++S L N Q I+ E I +
Sbjct: 1899 DKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAE---IDARNDSFT 1955
Query: 4936 SSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQC 4995
+ + + +L + K S +++ L +L+E ++ + R L + +
Sbjct: 1956 TCIELGKSLLAR--------KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWL-RLILEV 2006
Query: 4996 QRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEF---FSTEDQFHSNLEEL 5052
++ + A WL + L G V+ E+ +K H F +T D+ S LE L
Sbjct: 2007 HQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERL 2066
Query: 5053 HSL 5055
+L
Sbjct: 2067 TTL 2069
Score = 95.1 bits (235), Expect = 3e-18
Identities = 249/1456 (17%), Positives = 575/1456 (39%), Gaps = 166/1456 (11%)
Query: 1258 QAEKILDTEN----LFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDR--GH 1311
+ EKIL +++ L +LL H+ +S + +Q I ++GE + + G
Sbjct: 643 EKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAI---KEGEDMIAEEHFGS 699
Query: 1312 EELRK----LESTLDGLERSRERQERRIQVTLRKWERFETNKETV-------VRYLFQTG 1360
E++R+ + LE+ +++R++ +F+ + + + ++ + +
Sbjct: 700 EKIRERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLDILKIVSSSD 758
Query: 1361 SSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQA 1420
H+ + + S ++ E+ + +++ QA L +E +E P ++++
Sbjct: 759 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERY 818
Query: 1421 KSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMD 1480
K + E + + L++ + +M S + +WI EKE+ LN ++ D
Sbjct: 819 KEVAELTRLRKQALQDTLALYKMF--------SEADACELWIDEKEQWLNNMQIPEKLED 870
Query: 1481 MQISQIKVTIQEIE--SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELRE 1538
+++ Q + E E ++ S + + + A+ E IKA+ ++ + RE
Sbjct: 871 LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEK-EIKAQQDKLNTRWSQFRE 929
Query: 1539 HAQCLEGTILGHLSQQQKFEE--------------------------NLRKIQQSVSEFE 1572
+ +L LS Q E + +Q+ ++ E
Sbjct: 930 LVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGME 989
Query: 1573 -DKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAIT-AFSASARKVVNRDSCVQEAA 1630
D +A+ K+ E K+ EH D QA+ S + I+ + + NR++ + EA+
Sbjct: 990 RDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS 1049
Query: 1631 ALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRV 1690
LQQ D L F +WL R + +S +M +
Sbjct: 1050 KLQQFLRD-------------------------LDDFQSWLSRTQTAIASEDMPNTL--T 1082
Query: 1691 KVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP 1750
+ E L + ++NE+ + Y K+ + E + + ++ L+ LD W +L
Sbjct: 1083 EAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH 1142
Query: 1751 QIINKRINFLQSVVAEHQQF------DELLLSFSVWIKLFLSELQTTSEISIMDHQVALT 1804
++ R N L A +QQF E L+ ++ L +E+ TT E + A+
Sbjct: 1143 KMWENRQNLLSQSHA-YQQFLRDTKQAEAFLNNQEYV-LAHTEMPTTLE----GAEAAIK 1196
Query: 1805 RHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ--GKAEDCFQLFEEASQVVER 1862
+ +D +++ + ++ ++ +L S G + + +D + E + +
Sbjct: 1197 KQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLM 1256
Query: 1863 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESA 1922
R L +FLQ LS + + T + M+ +E+ ++L+ +A +
Sbjct: 1257 RLKDNRDLQKFLQDCQELSLWINEKMLTAQ---DMSYDEA----RNLHSKWLKHQAFMAE 1309
Query: 1923 AVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKA 1982
S L K + SE+ + ++L G + + L T Q++A L KA
Sbjct: 1310 LASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA 1369
Query: 1983 --FQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2040
F +L K + +E + + + ++ L+ LE+++ + E+ L+
Sbjct: 1370 ELFTQSCADLDKWLHGLESQIQSDDYGKDL-TSVNILLKKQQMLENQMEVRKKEIEELQS 1428
Query: 2041 KAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSK 2100
+A+ ++Q+ + EVD + ++ + + ++E + ++ + ++++ +
Sbjct: 1429 QAQALSQEGKS-TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW 1487
Query: 2101 VLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2160
V E T + + ++ K++T + ++ Q +D+ + ++++++ +
Sbjct: 1488 VGERMPLATSTDHG-HNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS 1546
Query: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2220
+ D++ ++ +EK ++ + + D E E W
Sbjct: 1547 AEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAA----EAEAW-------- 1594
Query: 2221 AENISNLDNHLRAEELLKEFESEV----KNKALR--LEELHSKVNDLKELTKNL--ETPP 2272
+S + ++ +EE K+ +S V K++ L +E+ V+ L + ++ L ++ P
Sbjct: 1595 ---MSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP 1651
Query: 2273 DLQFI---EADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2329
+ + I ++ + + K++ E +G L D + Q+ + ++D+ W + E +
Sbjct: 1652 ESERISMRQSKVDKLYAGLKDLAEERRGKL-DERHRLFQLNREVDDLEQWIAEREVVAGS 1710
Query: 2330 CAQNETCEALKKVKDIQKELQSQQSNISSTQ-ENLNSLCRKYHS---AELESLGRAMTGL 2385
+ E + +++ +E NI + + +N L + + ++ ++ GL
Sbjct: 1711 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1770
Query: 2386 IKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTG-DSKVLEA 2444
+ + +L L S E H + + +E F + K+ + G D +E
Sbjct: 1771 NEAWADLLELIDTRTQILAASYELH--KFYHDAKEIFGRIQDKHKKLPEELGRDQNTVET 1828
Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCL 2504
+ +++ + ++ L A + IQ++ + E +++ L C
Sbjct: 1829 LQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACE 1888
Query: 2505 KDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFL 2564
+ L D + F R L LW+ ++ + + EK +V VE+ +
Sbjct: 1889 SRRVRLVDTGDKF-RFFSMVRDLMLWMEDVIRQIEAQ----------EKPRDVSSVELLM 1937
Query: 2565 -------GELLAARESLDKLSQRGQLLSEEGHGAGQE-GRLCSQLLTSHQNLLRMTKEKL 2616
E+ A +S + G+ L H A +E QL + ++ +++
Sbjct: 1938 NNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRW 1997
Query: 2617 RSCQVALQEHEALEEA 2632
++ L+ H+ +A
Sbjct: 1998 EWLRLILEVHQFSRDA 2013
Score = 89.0 bits (219), Expect = 2e-16
Identities = 328/1871 (17%), Positives = 701/1871 (37%), Gaps = 223/1871 (11%)
Query: 4934 VQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYS 4993
+QS +R N +K + +LIS D+ + L + + + + ALR ++
Sbjct: 356 IQSKMRANN-----QKVYMPREGKLIS-DINKAWERLEKAEHERELALRNELIRQEKLEQ 409
Query: 4994 QCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELH 5053
+R+ + WL + Q L+ G D+ + E K H + + ++ +
Sbjct: 410 LARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVV 469
Query: 5054 SLVATLD-----PLIKPTGKED-----LEQKVASLELRSQRMSRDSGAQVDLLQRC-TAQ 5102
++ L+ + + T ++D E + L R QR+ + G Q +
Sbjct: 470 AVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMD 529
Query: 5103 WHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5162
W D K V+ L D K L E+ L +H + + + E++ +
Sbjct: 530 WMDEMK----VLVLSQDYGKHLL-----------GVEDLLQKHTLVEADIGIQAERVRGV 574
Query: 5163 EEKASQLEKTG---NDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5219
A + G + + + + L +A ++ LE++ W F
Sbjct: 575 NASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEM 634
Query: 5220 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSML 5279
++ E + ++K+ S ++ LL H F E + S +Q +
Sbjct: 635 AEE--EGWIREKEKILSSDDYGKDLTSVMRLLSKHRAF----EDEMSGRSGHFEQAIKEG 688
Query: 5280 QDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWV 5339
+D A + + I ++++ N+ E++ K +E + + + W+
Sbjct: 689 EDMIAEEHFGSEKIRERIIYIREQWANL-EQLSAIRKKRLEEASLLHQFQADADDIDAWM 747
Query: 5340 QE-----TKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPS 5394
+ + +G+ + +++ + + E N+R ++ + E+ + LP
Sbjct: 748 LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA--------SALPQ 799
Query: 5395 E-------------LSLQLAEVALDLKIRDQ-IQDKIKEVEQ-SKATSQELSRQIQKLAK 5439
E + + EVA ++R Q +QD + + S+A + EL I + +
Sbjct: 800 EHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACEL--WIDEKEQ 857
Query: 5440 DLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAK 5499
L + K + V+Q + + L E++ S++ ++ ++ + K +
Sbjct: 858 WLNNMQIPEKLEDLEVIQHRFES--LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 915
Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI-EKAKVLAHGTIAWNS 5558
+ KL Q R+ +R +A ++ Y+ WI EK KV+ N
Sbjct: 916 QQDKLNTRWSQ-FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGND 974
Query: 5559 ASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMS--QQVAELGRETEEL 5616
+ + + + I+++L + ++ + L S + + + ++AE+ EE+
Sbjct: 975 LAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEM 1034
Query: 5617 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLL 5676
+ +K R +L +A+K +++F +L Q+ L + Q + S + + L+ + LL
Sbjct: 1035 KTTLKNREASLGEASK-LQQFLRDLDDFQSWLSRTQTAIASED-----MPNTLTEAEKLL 1088
Query: 5677 SEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQ------HTAIQQC 5730
++ E++K ++ + +R ++V + L++ L H +
Sbjct: 1089 TQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENR 1148
Query: 5731 NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKG 5790
+ + Y+Q+ ++ K + + + + T+ ++ +A I + E+ +
Sbjct: 1149 QNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTT-LEGAEAAIKKQEDFMTTMDA 1207
Query: 5791 YQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTA 5850
+E+I ++ + L + ++ + +D + T S
Sbjct: 1208 NEEKINAVVETGRRLVSDGN-----INSDRIQEKVDSIDDRHRKNRETAS---------- 1252
Query: 5851 GRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5910
LL + + + + C+ S N QD++Y +A +
Sbjct: 1253 ----ELLMRLKDNRDLQKFLQD------CQELSLWINEKMLTAQDMSYDEARNLHSKWLK 1302
Query: 5911 AAKIHPSTSASQEFYE-------------PGLEPSATAKLGDLQRSWETLKNVISEKQRT 5957
++++E+ + P E KL L + WE L++ K +
Sbjct: 1303 HQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQR 1362
Query: 5958 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGR---SPESQMAEHQALMDEILMLQ 6014
L++A + + + S + + +E ++ +S + G+ S + + Q L +++ + +
Sbjct: 1363 LFDA-NKAELFTQSCADLDKWLHGLESQI-QSDDYGKDLTSVNILLKKQQMLENQMEVRK 1420
Query: 6015 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6074
EI ELQS A+ L E D + LTV + M + K LL K
Sbjct: 1421 KEIEELQSQ-AQALSQEGKSTDEVD----SKRLTVQTKFMELLEPLNERKHNLLASKEIH 1475
Query: 6075 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6134
Q +++ L W + + L T+ ++ + Q + EI+
Sbjct: 1476 QFNRDVEDEIL------------W-VGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQ 1522
Query: 6135 QKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTA 6194
+ ++ ++N++ + + + + Q L++L G L+E H ++L A
Sbjct: 1523 GHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH-RRLEEAHRA 1581
Query: 6195 QEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASR 6254
Q+ + A S +++ + Q S L++ + LEQ + + + ++
Sbjct: 1582 QQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKT 1641
Query: 6255 GEEILI-QHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLL 6313
++ H +E K D L G K AE++ R K + H+ F +++
Sbjct: 1642 SRALVADSHPESERISMRQSKVDKL-----YAGLKDLAEER-RGKLDERHRLFQLNREV- 1694
Query: 6314 QNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK 6373
+ EQ + R +++G QD VT L + F E + +G
Sbjct: 1695 -----DDLEQWIAER--EVVAG-----SHELGQDYEHVTM----LQERFREFARDTGNIG 1738
Query: 6374 RQSI----HLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEM 6429
++ + HL +L + + + + + ++ L A A L E +T +ILA
Sbjct: 1739 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDT---RTQILA-----A 1790
Query: 6430 SEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNF 6489
S E+ K + + F D + + LG + L + H ++ Q+
Sbjct: 1791 SYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQL 1850
Query: 6490 QNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDK 6549
Q D L + A +K +QK N E ++ + L ++ + L GDK
Sbjct: 1851 QEDAARLQAAYAGDKADDIQKREN----------EVLEAWKSLLDACESRRVRLVDTGDK 1900
Query: 6550 LQVEQPSMQELSKLQDMY-----DELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLET 6604
+ + ++D+ E + S +N + +K++ + +E
Sbjct: 1901 FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIEL 1960
Query: 6605 GQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES-----HMILTETLFRKIISFA---- 6655
G+ +A KE++ QL +K KE E +IL F + S A
Sbjct: 1961 GKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWL 2020
Query: 6656 VQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSR--QLEVVESSIP 6713
+ +E + + Q+ +++ KR E TW DE L R LE++E
Sbjct: 2021 LGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATW---DERFSALERLTTLELLE---- 2073
Query: 6714 SVGLVEENEDR 6724
V +E E+R
Sbjct: 2074 -VRRQQEEEER 2083
Score = 86.3 bits (212), Expect = 1e-15
Identities = 187/959 (19%), Positives = 387/959 (40%), Gaps = 112/959 (11%)
Query: 4889 FQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRIMNALSHK 4947
F EM+ W+R + LS Y +L + + K + ++E+ S A+ K
Sbjct: 630 FFWEMAEEEGWIREKEKILSSDDY-GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAI--K 686
Query: 4948 EKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAAND 5007
E E + S + + + E ++++ R+ L E Q FQA D
Sbjct: 687 EGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQ-----FQADAD 741
Query: 5008 ----WLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 5063
W+ D +++ + G D S + +K H + + L+ LH + L
Sbjct: 742 DIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-- 799
Query: 5064 KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIEL-MNDTEK 5122
+ D+ +++ +E R + ++ + + LQ A + + +A + EL +++ E+
Sbjct: 800 EHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA--DACELWIDEKEQ 857
Query: 5123 KLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLS 5182
L+ + + E + E +L +N+ ++ + + A QL +G+ + K +
Sbjct: 858 WLNNMQIPEKLEDLEVIQHRFE--SLEPEMNNQASRVAVVNQIARQLMHSGHPSEKE-IK 914
Query: 5183 RSMTTVWQRWTRLRAVAQDQEKILEDAVD------EWTGFNNKVKKATEMIDQLQDKLPG 5236
+ RW++ R + ++ L A+ E + +++ T++I+ QD L
Sbjct: 915 AQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD-LGN 973
Query: 5237 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
A + LT +E D +E + LS LQ A E P Q
Sbjct: 974 DLAGVMALQRKLTGME-RDLVAIEAK-------------LSDLQKEAEKLESEHPDQAQA 1019
Query: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET---QINSVKCWVQETKEYLGNPTIEI 5353
I + ++ E++KT K + L + ++ ++ + W+ T+ + + ++
Sbjct: 1020 ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE--DM 1077
Query: 5354 DAQLEELQILLTEATNHRQNIEKMAEE-QKEKYLGLYTILPSELSLQLAEVALDLKIRDQ 5412
L E + LLT+ N + I+ E+ QK + +G + + Q + L+ D
Sbjct: 1078 PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-EMVTQGQTDAQYMFLRQRLQALDT 1136
Query: 5413 IQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC 5472
+++ ++ +++ S Q+ +D T + V A T+ E +
Sbjct: 1137 GWNELHKMWENRQNLLSQSHAYQQFLRD--TKQAEAFLNNQEYVLAHTEMPTTLEGAEAA 1194
Query: 5473 NSK----LMELDAAVQKF---------LEQNGQLGKP-LAKKIGKLTELHQQTIRQAENR 5518
K + +DA +K L +G + + +K+ + + H++ A
Sbjct: 1195 IKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASEL 1254
Query: 5519 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEE--- 5575
L +L + + EL L WI + K+L ++++ A L +++ HQ + E
Sbjct: 1255 LMRLKDNRDLQKFLQDCQELSL-WINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELAS 1312
Query: 5576 SKEIDSELEAMTEKLQYLTSVYCTEKM-SQQVAELGRETEELRQMIKIRLQNLQDAAKDM 5634
+KE ++E E +Q ++ TE + +++ L + E L + + Q L DA K
Sbjct: 1313 NKEWLDKIEK--EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANK-A 1369
Query: 5635 KKFEAELKKLQAALEQAQATLTSPEVGR--LSLKEQLSHRQHLLSEMESLKPKVQAVQLC 5692
+ F L L ++ + S + G+ S+ L +Q L ++ME K +++ +Q
Sbjct: 1370 ELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ-- 1427
Query: 5693 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH--- 5749
A L +E ++ + Q ++ + E KH
Sbjct: 1428 -----------------SQAQALSQEGKSTDEVDSKRLTV-QTKFMELLEPLNERKHNLL 1469
Query: 5750 LQQLIEGAHREIEDK--------PVATS-----NIQELQAQISRHEELAQKIKGYQEQI 5795
+ I +R++ED+ P+ATS N+Q +Q I +++ L ++I+G+Q +I
Sbjct: 1470 ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRI 1528
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 299,997,449
Number of Sequences: 37866
Number of extensions: 13047490
Number of successful extensions: 85755
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 1100
Number of HSP's that attempted gapping in prelim test: 46066
Number of HSP's gapped (non-prelim): 21200
length of query: 8797
length of database: 18,247,518
effective HSP length: 128
effective length of query: 8669
effective length of database: 13,400,670
effective search space: 116170408230
effective search space used: 116170408230
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 75 (33.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.