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Search of human proteins with 14550407
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14550407 complement component 2 isoform 1 preproprotein
[Homo sapiens]
(752 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14550407 complement component 2 isoform 1 preproprotein [Homo... 1553 0.0
gi|225543438 complement component 2 isoform 2 preproprotein [Hom... 1238 0.0
gi|67782358 complement factor B preproprotein [Homo sapiens] 515 e-146
gi|148886654 polydom [Homo sapiens] 102 2e-21
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 101 3e-21
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 96 9e-20
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 96 9e-20
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 96 9e-20
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa... 83 8e-16
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap... 83 8e-16
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 82 2e-15
gi|205360905 testis-specific serine protease 1 [Homo sapiens] 82 2e-15
gi|148231605 ovochymase 2 [Homo sapiens] 82 2e-15
gi|187960042 selectin E precursor [Homo sapiens] 80 7e-15
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 78 3e-14
gi|157419154 selectin P precursor [Homo sapiens] 77 8e-14
gi|13994276 marapsin [Homo sapiens] 76 1e-13
gi|4506115 protein C [Homo sapiens] 75 3e-13
gi|32698940 transmembrane protease, serine 12 [Homo sapiens] 75 3e-13
gi|4502495 complement component 1, s subcomponent precursor [Hom... 74 4e-13
gi|41393602 complement component 1, s subcomponent precursor [Ho... 74 4e-13
gi|4506153 prostasin preproprotein [Homo sapiens] 74 5e-13
gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens] 74 6e-13
gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo ... 74 6e-13
gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo ... 74 6e-13
gi|148806900 epidermis-specific serine protease-like protein [Ho... 74 6e-13
gi|62912468 complement component 4 binding protein, beta chain i... 73 8e-13
gi|62912464 complement component 4 binding protein, beta chain i... 73 8e-13
gi|4502505 complement component 4 binding protein, beta chain is... 73 8e-13
gi|187761337 transmembrane protease, serine 11B [Homo sapiens] 73 8e-13
>gi|14550407 complement component 2 isoform 1 preproprotein [Homo
sapiens]
Length = 752
Score = 1553 bits (4022), Expect = 0.0
Identities = 752/752 (100%), Positives = 752/752 (100%)
Query: 1 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA 60
MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA
Sbjct: 1 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA 60
Query: 61 SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG 120
SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG
Sbjct: 61 SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG 120
Query: 121 FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN 180
FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN
Sbjct: 121 FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN 180
Query: 181 LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES 240
LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES
Sbjct: 181 LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES 240
Query: 241 LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFAS 300
LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFAS
Sbjct: 241 LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFAS 300
Query: 301 EPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGME 360
EPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGME
Sbjct: 301 EPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGME 360
Query: 361 TMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDW 420
TMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDW
Sbjct: 361 TMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDW 420
Query: 421 RELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPW 480
RELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPW
Sbjct: 421 RELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPW 480
Query: 481 HVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVI 540
HVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVI
Sbjct: 481 HVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVI 540
Query: 541 SPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTC 600
SPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTC
Sbjct: 541 SPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTC 600
Query: 601 RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVT 660
RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVT
Sbjct: 601 RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVT 660
Query: 661 DQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRS 720
DQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRS
Sbjct: 661 DQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRS 720
Query: 721 KVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL 752
KVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL
Sbjct: 721 KVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL 752
>gi|225543438 complement component 2 isoform 2 preproprotein [Homo
sapiens]
Length = 620
Score = 1238 bits (3204), Expect = 0.0
Identities = 605/605 (100%), Positives = 605/605 (100%)
Query: 148 AGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP 207
AGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP
Sbjct: 16 AGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP 75
Query: 208 YSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSE 267
YSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSE
Sbjct: 76 YSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSE 135
Query: 268 NDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENAN 327
NDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENAN
Sbjct: 136 NDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENAN 195
Query: 328 YKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKT 387
YKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKT
Sbjct: 196 YKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKT 255
Query: 388 AVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQ 447
AVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQ
Sbjct: 256 AVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQ 315
Query: 448 VFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAH 507
VFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAH
Sbjct: 316 VFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAH 375
Query: 508 CFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKL 567
CFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKL
Sbjct: 376 CFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKL 435
Query: 568 AQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNI 627
AQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNI
Sbjct: 436 AQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNI 495
Query: 628 NLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLER 687
NLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLER
Sbjct: 496 NLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLER 555
Query: 688 RFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVL 747
RFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVL
Sbjct: 556 RFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVL 615
Query: 748 NFLPL 752
NFLPL
Sbjct: 616 NFLPL 620
Score = 49.3 bits (116), Expect = 1e-05
Identities = 31/71 (43%), Positives = 37/71 (52%), Gaps = 7/71 (9%)
Query: 1 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA 60
MGPLMVLFCLLFLYP A CP N IS G + G + Y C L + +
Sbjct: 1 MGPLMVLFCLLFLYP-----AGHCP-NPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS 54
Query: 61 S-RLCKSSGQW 70
S R C+ +G W
Sbjct: 55 SERECQGNGVW 65
Score = 38.1 bits (87), Expect = 0.030
Identities = 13/35 (37%), Positives = 19/35 (54%)
Query: 110 GGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVC 144
G V + C +L GS R+C+ NG+W G +C
Sbjct: 38 GDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 72
>gi|67782358 complement factor B preproprotein [Homo sapiens]
Length = 764
Score = 515 bits (1326), Expect = e-146
Identities = 297/751 (39%), Positives = 424/751 (56%), Gaps = 44/751 (5%)
Query: 17 LADSAPSCP-QNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA-SRLCKSSGQWQTPG 74
LA SC + V I GG+F L G L Y CP G YP P +R C+S+G W T
Sbjct: 30 LARPQGSCSLEGVEIKGGSFRLLQ---EGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLK 86
Query: 75 AT--RSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCR 132
+++ KA C+ + CP P FENG Y PR Y V +SF C DG+ LRGS R C+
Sbjct: 87 TQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQ 146
Query: 133 PNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQ 192
NG W G+TA+CDNGAG+C NPGI +G + G ++ D V Y CS L L GS R CQ
Sbjct: 147 VNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQ 206
Query: 193 GNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPT--QKTKESLGRKIQIQRS 250
G WSGTEP C+ + YD P++VA A +S + + + E RKI + S
Sbjct: 207 EGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPS 266
Query: 251 GHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLN 310
G +N+YL+LD S S+ ++F K+ +++++ S+ + ++T+A+ PK+ + V
Sbjct: 267 GSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSE 326
Query: 311 DNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHA 370
+S + V L NY+DH+ +GTNT AL +VY MM+ + W RH
Sbjct: 327 ADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPD---DVPPEGWNRTRHV 383
Query: 371 IILLTDGKSNMGGSPKTAVDHIREILNINQ----KRNDYLDIYAIGVGKLDVDWRELNEL 426
IIL+TDG NMGG P T +D IR++L I + R DYLD+Y GVG L V+ +N L
Sbjct: 384 IILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPL-VNQVNINAL 442
Query: 427 GSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIK- 485
SKKD E+H F ++D + L VF M+D S+ + ++CG+ +D + PW I
Sbjct: 443 ASKKDNEQHVFKVKDMENLEDVFYQMIDESQ-SLSLCGMVWEHRKGTDYHKQPWQAKISV 501
Query: 486 ---PKSQETCRGALISDQWVLTAAHCFR-DGNDHSLWRVNVGDPKSQWGKEFLIEKAVIS 541
K E+C GA++S+ +VLTAAHCF D +HS+ +V+VG K ++ IE +
Sbjct: 502 IRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSI-KVSVGGEK----RDLEIEVVLFH 556
Query: 542 PGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCR 601
P +++ KK GI EFY D+AL+KL K+K RPICLPCT ALR P +TC+
Sbjct: 557 PNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQ 616
Query: 602 DHENELLNKQSVPAHFVALNGSKL---NINLKMGVEWTSCAEVVSQEKTMFPNLTDVREV 658
+ ELL Q + A FV+ KL + +K G + SC E +Q + + D+ EV
Sbjct: 617 QQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSC-ERDAQYAPGYDKVKDISEV 675
Query: 659 VTDQFLCSG---TQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRK 715
VT +FLC+G D + C+G+SGG + + +R RF QVG++SWG+ + C KN ++
Sbjct: 676 VTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVC-----KNQKR 730
Query: 716 RAPRSKVPP-PRDFHINLFRMQPWLRQHLGD 745
+ +VP RDFHINLF++ PWL++ L D
Sbjct: 731 ---QKQVPAHARDFHINLFQVLPWLKEKLQD 758
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 102 bits (253), Expect = 2e-21
Identities = 63/186 (33%), Positives = 86/186 (46%), Gaps = 18/186 (9%)
Query: 20 SAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRS 78
S+P N + G +T + Y+C +G L SR+C ++G W GAT
Sbjct: 2834 SSPPVSANGQVRGDEYTFQKE------IEYTCNEGFLLEGARSRVCLANGSWS--GATPD 2885
Query: 79 LSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWD 138
C PVRC P NG+ T L Y V+F C +G+IL G+P C+ +G WD
Sbjct: 2886 -----CVPVRCATPPQLANGV-TEGL-DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWD 2938
Query: 139 GETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWS 198
E +C +C P GF F HG ++Y+C L G+S R C NG WS
Sbjct: 2939 AEIPLCK--PVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWS 2996
Query: 199 GTEPIC 204
G+ P C
Sbjct: 2997 GSSPSC 3002
Score = 85.9 bits (211), Expect = 1e-16
Identities = 52/164 (31%), Positives = 77/164 (46%), Gaps = 14/164 (8%)
Query: 44 GSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAP-VSFENGIYT 101
G + YSC +G P+ C +G W P +CKP CP P V EN + +
Sbjct: 3318 GPNVVYSCNRGYSLEGPSEAHCTENGTWSHP-------VPLCKPNPCPVPFVIPENALLS 3370
Query: 102 PRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAV 161
+ + V NVS +C +GF+L+G + C P+ W +A C+ + C P A+
Sbjct: 3371 EK--EFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKIS--CGPPAHVENAI 3426
Query: 162 RTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
G + +GD + Y C S +L G C NG W+ + PICR
Sbjct: 3427 ARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWT-SPPICR 3469
Score = 85.1 bits (209), Expect = 2e-16
Identities = 58/209 (27%), Positives = 83/209 (39%), Gaps = 19/209 (9%)
Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLS 80
P+ N +I G +T S L Y C G + R C+ W
Sbjct: 2778 PNPVMNGSIKGSNYTYL------STLYYECDPGYVLNGTERRTCQDDKNWDE-------D 2824
Query: 81 KAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGE 140
+ +C PV C +P NG R Y + + C +GF+L G+ R C NG W G
Sbjct: 2825 EPICIPVDCSSPPVSANG--QVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGA 2882
Query: 141 TAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGT 200
T C C P V G +G +V + C +L G+ + CQ +G W
Sbjct: 2883 TPDCV--PVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAE 2940
Query: 201 EPICRQPYSYDFPEDVAPALGTSFSHMLG 229
P+C+ P + PED+A FS + G
Sbjct: 2941 IPLCK-PVNCGPPEDLAHGFPNGFSFIHG 2968
Score = 82.0 bits (201), Expect = 2e-15
Identities = 59/202 (29%), Positives = 82/202 (40%), Gaps = 18/202 (8%)
Query: 20 SAPSCPQNVNISGGTFTLSHG--WAPGSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGAT 76
S CP NI T L HG ++ ++ SC +G + +C+ G W+ P +
Sbjct: 3177 SPKKCPLPENI---THILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSD 3233
Query: 77 RSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGM 136
S C PV C P S E+G Y + ++CE G+ L G+ R C+ N
Sbjct: 3234 ES-----CSPVSCGKPESPEHGFVVG--SKYTFESTIIYQCEPGYELEGNRERVCQENRQ 3286
Query: 137 WDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV 196
W G A+C C P L G V Y C+ L G SE C NG
Sbjct: 3287 WSGGVAICKE--TRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGT 3344
Query: 197 WSGTEPICRQ---PYSYDFPED 215
WS P+C+ P + PE+
Sbjct: 3345 WSHPVPLCKPNPCPVPFVIPEN 3366
Score = 81.3 bits (199), Expect = 3e-15
Identities = 54/184 (29%), Positives = 76/184 (41%), Gaps = 18/184 (9%)
Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGATRSLS 80
P+ P+N I FT GS +TY C +G C ++ W S S
Sbjct: 1850 PAIPENGCIEELAFTF------GSKVTYRCNKGYTLAGDKESSCLANSSW-------SHS 1896
Query: 81 KAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGE 140
VC+PV+C +P + NG Y L S+ C+ G+ L+G + +C +G+WD
Sbjct: 1897 PPVCEPVKCSSPENINNGKYI--LSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRA 1954
Query: 141 TAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGT 200
C C P AV TG F + V Y C L G EC +G WS +
Sbjct: 1955 PPACH--LVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRS 2012
Query: 201 EPIC 204
+ C
Sbjct: 2013 DQQC 2016
Score = 80.9 bits (198), Expect = 4e-15
Identities = 58/210 (27%), Positives = 80/210 (38%), Gaps = 44/210 (20%)
Query: 44 GSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSL----------------------- 79
GS +TY C G Y SR+ C +G W G + S
Sbjct: 1709 GSTVTYQCNNGYYLLGDSRMFCTDNGSWN--GVSPSCLDVDECAVGSDCSEHASCLNVDG 1766
Query: 80 -------------SKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGS 126
K +P++C AP + ENG + + Y VG V+F C++G+ L G
Sbjct: 1767 SYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI--YTVGAEVTFSCQEGYQLMGV 1824
Query: 127 PVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS 186
C +G W+ C A C P I F G KV YRC+ L G
Sbjct: 1825 TKITCLESGEWNHLIPYCK--AVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGD 1882
Query: 187 SERECQGNGVWSGTEPICRQPYSYDFPEDV 216
E C N WS + P+C +P PE++
Sbjct: 1883 KESSCLANSSWSHSPPVC-EPVKCSSPENI 1911
Score = 80.1 bits (196), Expect = 7e-15
Identities = 54/183 (29%), Positives = 77/183 (42%), Gaps = 11/183 (6%)
Query: 35 FTLSHGWAPGSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPV 93
F + GS + + C +G +S C+ SG+W S C P +CP P
Sbjct: 2274 FMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKK------SNPKCMPAKCPEPP 2327
Query: 94 SFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPN 153
EN + L + G V+F C++G +L+G V +C P+ W+ VC P
Sbjct: 2328 LLENQLVLKELTTEV--GVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC-TPP 2384
Query: 154 PGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFP 213
P IS G G V+Y C L G+S CQ +G WS P C P P
Sbjct: 2385 PLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPEC-VPVECPQP 2443
Query: 214 EDV 216
E++
Sbjct: 2444 EEI 2446
Score = 79.7 bits (195), Expect = 9e-15
Identities = 51/171 (29%), Positives = 78/171 (45%), Gaps = 14/171 (8%)
Query: 36 TLSHGWAPGSLLTYSCPQG--LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPV 93
T S + G++++Y+C G L +P +C+ G W S C + C P
Sbjct: 2670 THSSNFLYGTMVSYTCNPGYELLGNPVL-ICQEDGTWNG-------SAPSCISIECDLPT 2721
Query: 94 SFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPN 153
+ ENG R +G V + C+ G IL GS +R C N W G + C+ + PN
Sbjct: 2722 APENGFL--RFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPN 2779
Query: 154 PGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
P + G+++ G + + + Y C VL G+ R CQ + W EPIC
Sbjct: 2780 P-VMNGSIK-GSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPIC 2828
Score = 76.3 bits (186), Expect = 1e-13
Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 11/176 (6%)
Query: 24 CPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASR-LCKSSGQWQTPGATRSLSKA 82
C + +I G + ++ G+++ YSC +G Y + C+++GQW +P T
Sbjct: 2146 CGEPPSIMNG-YASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPT------ 2198
Query: 83 VCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETA 142
C PV C P ENG G V ++C G+ GSPV C+ N W E+
Sbjct: 2199 -CHPVSCGEPPKVENGFLEHTTGRI-FESEVRYQCNPGYKSVGSPVFVCQANRHWHSESP 2256
Query: 143 VCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWS 198
+ P I G ++ G F G KV++ C+ L G S CQ +G W+
Sbjct: 2257 LMCVPLDCGKPPPIQNGFMK-GENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWN 2311
Score = 76.3 bits (186), Expect = 1e-13
Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 12/162 (7%)
Query: 44 GSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102
GS + YSC G + RLC + +W GA+ C+ + C P NG +
Sbjct: 2736 GSAVQYSCKPGHILAGSDLRLCLENRKWS--GASPR-----CEAISCKKPNPVMNG--SI 2786
Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162
+ +Y + +EC+ G++L G+ R C+ + WD + +C C +P +S
Sbjct: 2787 KGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICI--PVDCSSPPVSANGQV 2844
Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
G + ++ Y C+ +L G+ R C NG WSG P C
Sbjct: 2845 RGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDC 2886
Score = 70.5 bits (171), Expect = 6e-12
Identities = 48/178 (26%), Positives = 70/178 (39%), Gaps = 11/178 (6%)
Query: 41 WAPGSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGI 99
+A GS++++ C +G + ++++ C GQW S C PVRC P S NG
Sbjct: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNP-----SPMSIQCIPVRCGEPPSIMNGY 2156
Query: 100 YTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDN-GAGHCPNPGISL 158
+ +Y G V++ C GF ++G C G W C G P
Sbjct: 2157 ASG--SNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGF 2214
Query: 159 GAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDV 216
TG F +VRY+C+ GS CQ N W P+ P P +
Sbjct: 2215 LEHTTGRIFE--SEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPI 2270
Score = 69.3 bits (168), Expect = 1e-11
Identities = 45/161 (27%), Positives = 63/161 (39%), Gaps = 11/161 (6%)
Query: 46 LLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRL 104
++T+SC +G + P+ C S QW S VCK V C P G+ P
Sbjct: 2344 VVTFSCKEGHVLQGPSVLKCLPSQQWND-------SFPVCKIVLCTPPPLISFGVPIPSS 2396
Query: 105 GSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTG 164
+ G V + C GF LRG+ C+P+G W C CP P +
Sbjct: 2397 ALH-FGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECV--PVECPQPEEIPNGIIDV 2453
Query: 165 FRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
+ Y C L G++ C NG W G +P C+
Sbjct: 2454 QGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCK 2494
Score = 67.8 bits (164), Expect = 4e-11
Identities = 55/184 (29%), Positives = 75/184 (40%), Gaps = 14/184 (7%)
Query: 44 GSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102
G + Y C G +SR C S+G W S S C P RC PV E G T
Sbjct: 2968 GGHIQYQCFPGYKLHGNSSRRCLSNGSW-------SGSSPSCLPCRCSTPV-IEYG--TV 3017
Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162
+ G +C GF L G C +G W C++ + C + + A
Sbjct: 3018 NGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTS--CGSLPMIPNAFI 3075
Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGT 222
+ + + Y C S V+ GSS+ C GVWS P+C +P S P VA A+ T
Sbjct: 3076 SETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVC-EPLSCGSPPSVANAVAT 3134
Query: 223 SFSH 226
+H
Sbjct: 3135 GEAH 3138
Score = 67.4 bits (163), Expect = 5e-11
Identities = 50/182 (27%), Positives = 71/182 (39%), Gaps = 14/182 (7%)
Query: 24 CPQNVNISGGTFTLSHGWAPGSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGATRSLSKA 82
CPQ I G + G A S Y+C G + LC +G W K
Sbjct: 2440 CPQPEEIPNGIIDVQ-GLAYLSTALYTCKPGFELVGNTTTLCGENGHWLG-------GKP 2491
Query: 83 VCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETA 142
CK + C P NG ++ Y G V++ C GF L G C G WD +
Sbjct: 2492 TCKAIECLKPKEILNGKFSYTDLHY--GQTVTYSCNRGFRLEGPSALTCLETGDWDVDAP 2549
Query: 143 VCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEP 202
C+ A HC +P G + +G + Y C + G + + C+ +G WS + P
Sbjct: 2550 SCN--AIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIP 2606
Query: 203 IC 204
C
Sbjct: 2607 TC 2608
Score = 67.0 bits (162), Expect = 6e-11
Identities = 43/174 (24%), Positives = 68/174 (39%), Gaps = 4/174 (2%)
Query: 44 GSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102
G + Y C G + S+L C + G+W P + + + + P VS+ + +
Sbjct: 2040 GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEG-QDMPRCIAHFCEKPPSVSYSI-LESV 2097
Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162
+ G VSF+C +GF+L S +C G W+ C P +
Sbjct: 2098 SKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYA 2157
Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDV 216
+G + G V Y C+ + G + C+ G WS P C P S P V
Sbjct: 2158 SGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTC-HPVSCGEPPKV 2210
Score = 66.6 bits (161), Expect = 8e-11
Identities = 53/192 (27%), Positives = 70/192 (36%), Gaps = 31/192 (16%)
Query: 50 SCPQGLYPSPASR-------LCKSSGQWQTPGATRS----------LSKAVCKPVRCPAP 92
+CP G Y S C PG+T S C+ V CPA
Sbjct: 322 ACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPAL 381
Query: 93 VSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCP 152
ENG + + C GF L GS + C PNG+W G + C CP
Sbjct: 382 KPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYC--RVRTCP 439
Query: 153 NPGISLGAVRTGFRFGHGDKVRYR------CSSNLVLTGSSERECQGNGVWSGTEPIC-- 204
+ L + G ++ Y+ C L GS + CQGN W G EP C
Sbjct: 440 H----LRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVE 495
Query: 205 RQPYSYDFPEDV 216
R ++ P+DV
Sbjct: 496 RHCSTFQMPKDV 507
Score = 57.8 bits (138), Expect = 4e-08
Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 10/99 (10%)
Query: 110 GGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFR--- 166
G V+ C+ GF L G+PV+ C G W C+ + P P + GF
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPP------LENGFHSAD 1704
Query: 167 -FGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
F G V Y+C++ L G S C NG W+G P C
Sbjct: 1705 DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSC 1743
Score = 57.4 bits (137), Expect = 5e-08
Identities = 50/211 (23%), Positives = 74/211 (35%), Gaps = 51/211 (24%)
Query: 36 TLSHGWAPGSLLTYSCPQG--LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPV 93
T S PGS + C G L +P + C + GQW P C+ + C P
Sbjct: 1643 TASEDLKPGSKVNLFCDPGFQLVGNPV-QYCLNQGQWTQP-------LPHCERISCGVPP 1694
Query: 94 SFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDG-------------- 139
ENG ++ + G V+++C +G+ L G C NG W+G
Sbjct: 1695 PLENGFHS--ADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVG 1752
Query: 140 ----ETAVCDNGAG---------------------HCPNPGISLGAVRTGFRFGHGDKVR 174
E A C N G C PG +G + G +V
Sbjct: 1753 SDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVT 1812
Query: 175 YRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
+ C L G ++ C +G W+ P C+
Sbjct: 1813 FSCQEGYQLMGVTKITCLESGEWNHLIPYCK 1843
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 101 bits (251), Expect = 3e-21
Identities = 70/224 (31%), Positives = 100/224 (44%), Gaps = 25/224 (11%)
Query: 20 SAPSCPQNVNISGGTFTLSHGWAPGSLLT------YSCPQGLYP---SPASRLCKSSGQW 70
+AP C + G TL++G G+ T Y C G + A+ C G+W
Sbjct: 3029 TAPDC--TIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRW 3086
Query: 71 QTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQ 130
SK VCK V CP P +NG T + G ++S+ C DG+ L S +
Sbjct: 3087 NP-------SKPVCKAVLCPQPPPVQNG--TVEGSDFRWGSSISYSCMDGYQLSHSAILS 3137
Query: 131 CRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERE 190
C G+W GE C C +PGI +G F + +V ++C S +L GSS R
Sbjct: 3138 CEGRGVWKGEIPQCL--PVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRV 3195
Query: 191 CQGNGVWSGTEPICRQPYSYDFPEDVAPALG---TSFSHMLGAT 231
CQ +G WSG +P C P P+ P G +S + +G+T
Sbjct: 3196 CQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGST 3239
Score = 92.8 bits (229), Expect = 1e-18
Identities = 59/177 (33%), Positives = 82/177 (46%), Gaps = 19/177 (10%)
Query: 38 SHGWAPGS------LLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCP 90
+HG+ GS ++ ++C G SR C+S+GQW +P T C+ V C
Sbjct: 2746 AHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPT-------CRVVNCS 2798
Query: 91 APVSFENGIYTPRLG---SYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNG 147
P EN I + S+ G ++ + C+ GF L GS C NG+WD C
Sbjct: 2799 DPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKC--L 2856
Query: 148 AGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
A C +PG+ AV TG F +G V Y C + L G+ R CQ + WSG P C
Sbjct: 2857 AISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHC 2913
Score = 82.0 bits (201), Expect = 2e-15
Identities = 54/163 (33%), Positives = 71/163 (43%), Gaps = 11/163 (6%)
Query: 44 GSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102
G + Y C +G Y +S L C ++G W RSL K C + C P N + T
Sbjct: 2821 GMSILYHCKKGFYLLGSSALTCMANGLWD-----RSLPK--CLAISCGHPGVPANAVLTG 2873
Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCD-NGAGHCPNPGISLGAV 161
L +Y G V + C L G+ R C+ + W G C N G C +PG
Sbjct: 2874 ELFTY--GAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGS 2931
Query: 162 RTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
R G F +R+ C L GS ER C NG WSG +P+C
Sbjct: 2932 RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVC 2974
Score = 79.7 bits (195), Expect = 9e-15
Identities = 52/162 (32%), Positives = 72/162 (44%), Gaps = 10/162 (6%)
Query: 44 GSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102
G+ + SC G Y L C+++G W S C+ + C + NG
Sbjct: 2582 GAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPS-----CRVISCGSLSFPPNGNKIG 2636
Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162
L Y G F C G+ L GS VR+C NG+W G C AGHC +P +
Sbjct: 2637 TLTVY--GATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCL--AGHCGSPDPIVNGHI 2692
Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
+G F + D V Y+C+ L G+S R C + WSG P+C
Sbjct: 2693 SGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVC 2734
Score = 73.2 bits (178), Expect = 8e-13
Identities = 61/201 (30%), Positives = 83/201 (41%), Gaps = 30/201 (14%)
Query: 17 LADSAPSC----------PQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPAS--RLC 64
+ D PSC P N N GT T+ G+ ++C G Y S R C
Sbjct: 2611 IGDERPSCRVISCGSLSFPPNGN-KIGTLTVY-----GATAIFTCNTG-YTLVGSHVREC 2663
Query: 65 KSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILR 124
++G W S S+ C C +P NG + SY V ++C GF L
Sbjct: 2664 LANGLW-------SGSETRCLAGHCGSPDPIVNGHISGDGFSYR--DTVVYQCNPGFRLV 2714
Query: 125 GSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT 184
G+ VR C + W G+T VC C +PG G F D V + C++ +L
Sbjct: 2715 GTSVRICLQDHKWSGQTPVCVPIT--CGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQ 2772
Query: 185 GSSERECQGNGVWSGTEPICR 205
G S +C+ NG WS P CR
Sbjct: 2773 GVSRAQCRSNGQWSSPLPTCR 2793
Score = 72.8 bits (177), Expect = 1e-12
Identities = 59/189 (31%), Positives = 80/189 (42%), Gaps = 24/189 (12%)
Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSC--PQGLYPSPASRLCKSSGQWQ--TPGATR 77
P P N ++G FT G+++ YSC + L + +R+C+ W P T
Sbjct: 2863 PGVPANAVLTGELFTY------GAVVHYSCRGSESLIGND-TRVCQEDSHWSGALPHCTG 2915
Query: 78 SLSKAVCKPVRCPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRPNGM 136
+ P C P + +G RLG + + F CE G LRGSP R C NG
Sbjct: 2916 N------NPGFCGDPGTPAHG---SRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGS 2966
Query: 137 WDGETAVCDNGAGHCPNPGI-SLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNG 195
W G VC+ A C NPG + G + + V Y C +G R C NG
Sbjct: 2967 WSGLQPVCE--AVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANG 3024
Query: 196 VWSGTEPIC 204
W+GT P C
Sbjct: 3025 TWTGTAPDC 3033
Score = 62.8 bits (151), Expect = 1e-09
Identities = 53/189 (28%), Positives = 73/189 (38%), Gaps = 20/189 (10%)
Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLS 80
P P +SG +FT S + + C + + R+C++ G W +
Sbjct: 3159 PGIPAEGRLSGKSFTYK------SEVFFQCKSPFILVGSSRRVCQADGTWS------GIQ 3206
Query: 81 KAVCKPVR--CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWD 138
P CP P + GI G Y VG V F C G+ ++GS R C N W
Sbjct: 3207 PTCIDPAHNTCPDPGTPHFGIQNSSRG-YEVGSTVFFRCRKGYHIQGSTTRTCLANLTWS 3265
Query: 139 GETAVCDNGAGHCPNPGISLGA-VRTGFRFGHGDKVRYRCSSNLVLTGSSE-RECQGNGV 196
G C A C P A VR G + Y C L G SE R C+ +
Sbjct: 3266 GIQTECIPHA--CRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMK 3323
Query: 197 WSGTEPICR 205
W+G P+C+
Sbjct: 3324 WTGKSPVCK 3332
Score = 54.3 bits (129), Expect = 4e-07
Identities = 55/200 (27%), Positives = 80/200 (40%), Gaps = 23/200 (11%)
Query: 20 SAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGL-YPSPASRLCKSS--GQWQTPGAT 76
+AP C + G A GS + Y C G ++ C+ + G +Q T
Sbjct: 2429 AAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLT 2488
Query: 77 RSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSP--VRQCRPN 134
+C+ V C P S NG +T + + V +EC +GF L S C+ +
Sbjct: 2489 -----PLCQAVSCGIPESPGNGSFTGN--EFTLDSKVVYECHEGFKLESSQQATAVCQED 2541
Query: 135 GMWD--GETAVCDNGAGHCPNPGISLGA-----VRTGFRFGHGDKVRYRCSSNLVLTGSS 187
G+W G+ C A CP+ L + +G +G +V CS L G
Sbjct: 2542 GLWSNKGKPPTCKPVA--CPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWR 2599
Query: 188 ERECQGNGVWS-GTE-PICR 205
CQ NG W+ G E P CR
Sbjct: 2600 LLRCQANGTWNIGDERPSCR 2619
Score = 50.4 bits (119), Expect = 6e-06
Identities = 23/56 (41%), Positives = 28/56 (50%)
Query: 149 GHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
G C +PGI RTG F HGD + + C + L G CQ N WSG +P C
Sbjct: 526 GGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/65 (40%), Positives = 29/65 (44%), Gaps = 4/65 (6%)
Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT-GSSEREC---QGNGVWSGTEP 202
G C +PGI + R G RF G V + C V T GS C GN VWS T P
Sbjct: 694 GQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVP 753
Query: 203 ICRQP 207
C P
Sbjct: 754 RCEAP 758
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/64 (40%), Positives = 32/64 (50%), Gaps = 4/64 (6%)
Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRP--NGMWDGETAVCDN 146
CP P F+NG Y VG +VSFEC G+IL G PV C+ N W+ CD
Sbjct: 2088 CPDPPPFQNGYMIN--SDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDA 2145
Query: 147 GAGH 150
G+
Sbjct: 2146 PCGY 2149
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/59 (42%), Positives = 28/59 (47%), Gaps = 4/59 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC---QGNGV-WSGTEPICR 205
C NPG L V G RF GDK+RY C +L G + C GNG W P CR
Sbjct: 145 CGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCR 203
Score = 43.5 bits (101), Expect = 7e-04
Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNG--VWSGTEPIC 204
C +PG+ + R GF FG GD + + C L G+++ C G G VWS P C
Sbjct: 1046 CDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRC 1101
Score = 42.4 bits (98), Expect = 0.002
Identities = 32/106 (30%), Positives = 43/106 (40%), Gaps = 11/106 (10%)
Query: 110 GGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNG-----AGHCPNPGISLGAVRTG 164
G N F+ + L+ V+ P+ + +V G + CP+PGI R G
Sbjct: 304 GFNAQFQVKKAIELKSRGVKML-PSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAG 362
Query: 165 FRFGH-GDKVRYRCSSNLVLTGSSERECQ----GNGVWSGTEPICR 205
F G V++ C N VL GS CQ WS PICR
Sbjct: 363 SDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408
Score = 36.6 bits (83), Expect = 0.088
Identities = 29/92 (31%), Positives = 39/92 (42%), Gaps = 5/92 (5%)
Query: 162 RTGFRFGHGDKVRYRCSSNLVLTGSSERECQG--NGV--WSGTEPICRQPYSYDFPEDVA 217
R G F G VR+ C+ +L GS+ CQ N + W+ T P C P S +F +
Sbjct: 1753 RIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPCSGNFTQRRG 1812
Query: 218 PALGTSFSHMLGAT-NPTQKTKESLGRKIQIQ 248
L + G N K + G IQIQ
Sbjct: 1813 TILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQ 1844
Score = 35.4 bits (80), Expect = 0.20
Identities = 21/46 (45%), Positives = 25/46 (54%), Gaps = 5/46 (10%)
Query: 89 CPAPVSFENGIYTPRLGS--YPVGGNVSFECEDGFILRGSPVRQCR 132
CP P ENG R GS VG NV F CED ++L+GS C+
Sbjct: 349 CPDPGIPENG---RRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQ 391
Score = 33.5 bits (75), Expect = 0.75
Identities = 19/80 (23%), Positives = 27/80 (33%), Gaps = 4/80 (5%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICRQ 206
C +PG + R G F G + Y+C S + S C G W P C
Sbjct: 1565 CFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNA 1624
Query: 207 PYSYDFPEDVAPALGTSFSH 226
P + L ++ H
Sbjct: 1625 PCGGQYTGSEGVVLSPNYPH 1644
Score = 33.1 bits (74), Expect = 0.97
Identities = 16/54 (29%), Positives = 22/54 (40%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
C +PGI + R G FG V + C L+ C+ N W+ P C
Sbjct: 874 CLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC 927
Score = 32.3 bits (72), Expect = 1.7
Identities = 17/46 (36%), Positives = 21/46 (45%), Gaps = 1/46 (2%)
Query: 100 YTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVC 144
Y R GS + G ++FEC F L G V C+ N W G C
Sbjct: 536 YGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581
Score = 32.3 bits (72), Expect = 1.7
Identities = 18/50 (36%), Positives = 26/50 (52%), Gaps = 5/50 (10%)
Query: 100 YTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCR--PNGM--WDGETAVC 144
Y R+GS + G V FEC G++L+GS C+ PN + W+ C
Sbjct: 1750 YGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 96.3 bits (238), Expect = 9e-20
Identities = 57/172 (33%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 36 TLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVS 94
T +G+ ++T+SC G L P C+++ QW P +CK V C P
Sbjct: 2846 TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP-------PPMCKVVNCSDPGI 2898
Query: 95 FENGIYTPRL--GSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCP 152
N ++ G++ G V ++C G+ L GS V C+PNG WD C C
Sbjct: 2899 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI--MIDCG 2956
Query: 153 NPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
+PG+ AV +G ++ G V Y C+ L G S R CQ NG WSG++P C
Sbjct: 2957 HPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 3008
Score = 82.8 bits (203), Expect = 1e-15
Identities = 59/192 (30%), Positives = 77/192 (40%), Gaps = 21/192 (10%)
Query: 20 SAPSCPQNVN----ISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRL-CKSSGQWQTPG 74
S P P N I G FT G+++ Y C G + +S L C+ +GQW P
Sbjct: 2894 SDPGIPANSKRESKIEHGNFTY------GTVVFYDCNPGYFLFGSSVLICQPNGQWDKP- 2946
Query: 75 ATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPN 134
C + C P N + + Y G V + C L G R C+ N
Sbjct: 2947 ------LPECIMIDCGHPGVPPNAVLSGE--KYTFGSTVHYSCTGKRSLLGQSSRTCQLN 2998
Query: 135 GMWDGETAVCDNGA-GHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG 193
G W G C A G C +PG R F VRY C + +L GS ER C
Sbjct: 2999 GHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 3058
Query: 194 NGVWSGTEPICR 205
NG W+G +P C+
Sbjct: 3059 NGSWTGRQPECK 3070
Score = 82.4 bits (202), Expect = 1e-15
Identities = 52/167 (31%), Positives = 71/167 (42%), Gaps = 14/167 (8%)
Query: 44 GSLLTYSCPQGL---YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIY 100
G ++Y C G R C +G W T C+ V CP P NG
Sbjct: 3152 GQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPT-------CRAVTCPTPPQISNGRL 3204
Query: 101 TPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA 160
++ G ++S+ C G+ L V C NG W GE C C +PGI
Sbjct: 3205 EGT--NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL--PKFCGDPGIPAQG 3260
Query: 161 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP 207
R G F + +V + C+ +L GSS R CQ +G WSG+ P C +P
Sbjct: 3261 KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEP 3307
Score = 80.5 bits (197), Expect = 5e-15
Identities = 59/196 (30%), Positives = 83/196 (42%), Gaps = 19/196 (9%)
Query: 19 DSAPSCPQNVNISGGTFTLSHG---------WAPGSLLTYSCPQGLYP-SPASRLCKSSG 68
+ P C S +F L HG + + + +SC G + PAS C +G
Sbjct: 2644 NKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNG 2703
Query: 69 QWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPV 128
W + C+ + C + NG SY G F C+ GF+L GS V
Sbjct: 2704 TWSWRN-----ERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAV 2756
Query: 129 RQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE 188
R+C +G+W C AGHC P + + G +G+ D V Y+C+ L GSS
Sbjct: 2757 RECLSSGLWSESETRCL--AGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSV 2814
Query: 189 RECQGNGVWSGTEPIC 204
R CQ + WSG P C
Sbjct: 2815 RICQQDHNWSGQLPSC 2830
Score = 80.5 bits (197), Expect = 5e-15
Identities = 61/186 (32%), Positives = 79/186 (42%), Gaps = 24/186 (12%)
Query: 30 ISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVR 88
I G TF+ S + YSC +G + P+ R C ++G W S + C +
Sbjct: 3088 IDGTTFSSS--------VIYSCMEGYILSGPSVRQCTANGTW-------SGTLPNCTIIS 3132
Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFI--LRGSPVRQCRPNGMWDGETAVCD 145
C P NG+ R G Y VG NVS+ C+ G+ L GS +R C NG W G C
Sbjct: 3133 CGDPGIPANGL---RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3189
Query: 146 NGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
A CP P G F G + Y CS L+ + C GNG WSG P C
Sbjct: 3190 --AVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3247
Query: 206 QPYSYD 211
+ D
Sbjct: 3248 PKFCGD 3253
Score = 77.4 bits (189), Expect = 4e-14
Identities = 59/188 (31%), Positives = 80/188 (42%), Gaps = 22/188 (11%)
Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCP-QGLYPSPASRLCKSSGQWQTPGATRSLS 80
P P N +SG +T GS + YSC + +SR C+ +G W S S
Sbjct: 2958 PGVPPNAVLSGEKYTF------GSTVHYSCTGKRSLLGQSSRTCQLNGHW-------SGS 3004
Query: 81 KAVCK---PVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMW 137
+ C C P + +G + + ++ V + C+ G+IL GS R C NG W
Sbjct: 3005 QPHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSW 3062
Query: 138 DGETAVCDNGAGHCPNPGISL-GAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV 196
G C A C NPG + G V V Y C +L+G S R+C NG
Sbjct: 3063 TGRQPECK--AVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 3120
Query: 197 WSGTEPIC 204
WSGT P C
Sbjct: 3121 WSGTLPNC 3128
Score = 71.6 bits (174), Expect = 2e-12
Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 12/163 (7%)
Query: 44 GSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102
GS ++C G + A R C SSG W S S+ C C P NG
Sbjct: 2738 GSTAIFTCDLGFMLVGSAVRECLSSGLW-------SESETRCLAGHCGIPELIVNGQVIG 2790
Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162
+Y V ++C GF L GS VR C+ + W G+ C + C +PG +
Sbjct: 2791 E--NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS--CGHPGSPIYGRT 2846
Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
+G F D V + C+ ++ G ++ +CQ N WS P+C+
Sbjct: 2847 SGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2889
Score = 67.0 bits (162), Expect = 6e-11
Identities = 56/172 (32%), Positives = 75/172 (43%), Gaps = 24/172 (13%)
Query: 60 ASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFEN-GIYTPRLGS------YPVGGN 112
++R+C++ G W S S C P S EN G+ PR GS + VG
Sbjct: 3287 STRICQADGTW-------SGSSPHCIE---PTQTSCENPGV--PRHGSQNNTFGFQVGSV 3334
Query: 113 VSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRF-GHGD 171
V F C+ G +L+GS R C P+ W G C + C P A G HG
Sbjct: 3335 VQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHS--CKQPETPAHANVVGMDLPSHGY 3392
Query: 172 KVRYRCSSNLVLTGSSE-RECQGNGVWSGTEPICRQPYSYDFPEDVAPALGT 222
+ Y C L G +E R C+ + W+G PIC + S +D PALGT
Sbjct: 3393 TLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC-EAGSKILVKDPRPALGT 3443
Score = 49.3 bits (116), Expect = 1e-05
Identities = 26/56 (46%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNG--VWSGTEPIC 204
C +PGI R GF FG GD + + CSS L G+SE C G G VWS P C
Sbjct: 1142 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1197
Score = 47.8 bits (112), Expect = 4e-05
Identities = 24/59 (40%), Positives = 29/59 (49%), Gaps = 4/59 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV----WSGTEPICR 205
C NPG+ V G RF GDK+RY C + +L G + C N V W PICR
Sbjct: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196
Score = 46.6 bits (109), Expect = 9e-05
Identities = 24/79 (30%), Positives = 32/79 (40%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSY 210
C +PG L +R G F + D +R+ C L G CQ N WS PIC P
Sbjct: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683
Query: 211 DFPEDVAPALGTSFSHMLG 229
+F + L + G
Sbjct: 684 NFTAPMGTVLSPDYPEGYG 702
Score = 46.6 bits (109), Expect = 9e-05
Identities = 47/202 (23%), Positives = 73/202 (36%), Gaps = 23/202 (11%)
Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT-GSSEREC---QGNGVWSGTEP 202
G CP+PGI + A R G F G + C + T G+ C G +WSG P
Sbjct: 790 GHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 849
Query: 203 ICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCS 262
C P F L + K+SL + I+ ++ + +
Sbjct: 850 KCGAPCGGHFSAPSGVILSPGWPGYY---------KDSLNCEWVIEAEPGHSIKITFERF 900
Query: 263 QSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISS 322
Q+ D L + +L+ + S+ V F+S + + DNSR
Sbjct: 901 QTELNYDVLEVHDGPNLLSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSR-------- 951
Query: 323 LENANYKDHENGTGTNTYAALN 344
N +K H NTY+ L+
Sbjct: 952 -SNNGFKIHYESVTVNTYSCLD 972
Score = 38.5 bits (88), Expect = 0.023
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 4/59 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG----NGVWSGTEPICR 205
CP+PG R G F G V++ C + VL G+ CQ WS P+C+
Sbjct: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504
Score = 35.8 bits (81), Expect = 0.15
Identities = 19/60 (31%), Positives = 25/60 (41%), Gaps = 2/60 (3%)
Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV--WSGTEPIC 204
G CP P ++ G R+ GD V ++C L G S C V W+ PIC
Sbjct: 2008 GLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067
Score = 34.7 bits (78), Expect = 0.33
Identities = 18/54 (33%), Positives = 23/54 (42%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
C +PGI + R G F G V + C S L+ C+ N WS P C
Sbjct: 970 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023
Score = 34.7 bits (78), Expect = 0.33
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 6/59 (10%)
Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRPNGM--WDGETAVC 144
CP P + +GI ++G Y VG VSF+C+ G+ L+G C P + W+ +C
Sbjct: 2012 CPEPQTPSSGI---KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067
Score = 34.3 bits (77), Expect = 0.44
Identities = 19/79 (24%), Positives = 29/79 (36%), Gaps = 3/79 (3%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC---QGNGVWSGTEPICRQP 207
C +PG+ + R G GD V ++C L G C + W + P+C P
Sbjct: 1488 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1547
Query: 208 YSYDFPEDVAPALGTSFSH 226
+ L +F H
Sbjct: 1548 CGGNLTGSSGFILSPNFPH 1566
Score = 34.3 bits (77), Expect = 0.44
Identities = 19/61 (31%), Positives = 24/61 (39%), Gaps = 4/61 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICRQ 206
C +PG + R G + G V Y C + VL G S C G W+ P C
Sbjct: 1661 CFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1720
Query: 207 P 207
P
Sbjct: 1721 P 1721
Score = 32.7 bits (73), Expect = 1.3
Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 4/45 (8%)
Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCR 132
CP P ENG R+GS + +G V F C++ ++L+G+ C+
Sbjct: 446 CPDPGEPENG---KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQ 487
Score = 32.3 bits (72), Expect = 1.7
Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 18/141 (12%)
Query: 103 RLGS-YPVGGNVSFECEDGFILRGSPVRQCR--PNGM--WDGETAVCDNGAGHCPNPGIS 157
R+G+ + VG +V F+C G+IL GS +C PN + W+ C G
Sbjct: 1849 RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG-------G 1901
Query: 158 LGAVRTGFRFGHGDKVRYRCSSNLV--LTGSSERECQGNGVWSGTEPICRQPYSYDFPED 215
+ R G G Y + N V +T Q V TE YD ++
Sbjct: 1902 ILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDN 1961
Query: 216 VAPAL----GTSFSHMLGATN 232
AP L GT+ H+L +T+
Sbjct: 1962 NAPRLGSYSGTTIPHLLNSTS 1982
Score = 32.3 bits (72), Expect = 1.7
Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 2/43 (4%)
Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQC 131
CP P F NG + VG +SFEC G+ L G+ C
Sbjct: 2184 CPDPRPFRNGFVIGN--DFTVGQTISFECFPGYTLIGNSALTC 2224
Score = 30.8 bits (68), Expect = 4.8
Identities = 12/39 (30%), Positives = 16/39 (41%)
Query: 107 YPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCD 145
+ +G VSF C+ G+ L C N W CD
Sbjct: 986 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD 1024
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 96.3 bits (238), Expect = 9e-20
Identities = 57/172 (33%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 36 TLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVS 94
T +G+ ++T+SC G L P C+++ QW P +CK V C P
Sbjct: 2717 TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP-------PPMCKVVNCSDPGI 2769
Query: 95 FENGIYTPRL--GSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCP 152
N ++ G++ G V ++C G+ L GS V C+PNG WD C C
Sbjct: 2770 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI--MIDCG 2827
Query: 153 NPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
+PG+ AV +G ++ G V Y C+ L G S R CQ NG WSG++P C
Sbjct: 2828 HPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 2879
Score = 83.2 bits (204), Expect = 8e-16
Identities = 60/186 (32%), Positives = 80/186 (43%), Gaps = 18/186 (9%)
Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSP---ASRLCKSSGQWQTPGATRS 78
P P N GG T + G+ +TY C G S + +C+S G W T
Sbjct: 2531 PKAPTN----GGILTTDY--LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPR 2584
Query: 79 LSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWD 138
C + C + NG SY G F C+ GF+L GS VR+C +G+W
Sbjct: 2585 -----CVVISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWS 2637
Query: 139 GETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWS 198
C AGHC P + + G +G+ D V Y+C+ L GSS R CQ + WS
Sbjct: 2638 ESETRCL--AGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWS 2695
Query: 199 GTEPIC 204
G P C
Sbjct: 2696 GQLPSC 2701
Score = 82.8 bits (203), Expect = 1e-15
Identities = 59/192 (30%), Positives = 77/192 (40%), Gaps = 21/192 (10%)
Query: 20 SAPSCPQNVN----ISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRL-CKSSGQWQTPG 74
S P P N I G FT G+++ Y C G + +S L C+ +GQW P
Sbjct: 2765 SDPGIPANSKRESKIEHGNFTY------GTVVFYDCNPGYFLFGSSVLICQPNGQWDKP- 2817
Query: 75 ATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPN 134
C + C P N + + Y G V + C L G R C+ N
Sbjct: 2818 ------LPECIMIDCGHPGVPPNAVLSGE--KYTFGSTVHYSCTGKRSLLGQSSRTCQLN 2869
Query: 135 GMWDGETAVCDNGA-GHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG 193
G W G C A G C +PG R F VRY C + +L GS ER C
Sbjct: 2870 GHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 2929
Query: 194 NGVWSGTEPICR 205
NG W+G +P C+
Sbjct: 2930 NGSWTGRQPECK 2941
Score = 82.4 bits (202), Expect = 1e-15
Identities = 52/167 (31%), Positives = 71/167 (42%), Gaps = 14/167 (8%)
Query: 44 GSLLTYSCPQGL---YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIY 100
G ++Y C G R C +G W T C+ V CP P NG
Sbjct: 3023 GQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPT-------CRAVTCPTPPQISNGRL 3075
Query: 101 TPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA 160
++ G ++S+ C G+ L V C NG W GE C C +PGI
Sbjct: 3076 EGT--NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL--PKFCGDPGIPAQG 3131
Query: 161 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP 207
R G F + +V + C+ +L GSS R CQ +G WSG+ P C +P
Sbjct: 3132 KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEP 3178
Score = 80.5 bits (197), Expect = 5e-15
Identities = 61/186 (32%), Positives = 79/186 (42%), Gaps = 24/186 (12%)
Query: 30 ISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVR 88
I G TF+ S + YSC +G + P+ R C ++G W S + C +
Sbjct: 2959 IDGTTFSSS--------VIYSCMEGYILSGPSVRQCTANGTW-------SGTLPNCTIIS 3003
Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFI--LRGSPVRQCRPNGMWDGETAVCD 145
C P NG+ R G Y VG NVS+ C+ G+ L GS +R C NG W G C
Sbjct: 3004 CGDPGIPANGL---RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3060
Query: 146 NGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
A CP P G F G + Y CS L+ + C GNG WSG P C
Sbjct: 3061 --AVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3118
Query: 206 QPYSYD 211
+ D
Sbjct: 3119 PKFCGD 3124
Score = 77.4 bits (189), Expect = 4e-14
Identities = 59/188 (31%), Positives = 80/188 (42%), Gaps = 22/188 (11%)
Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCP-QGLYPSPASRLCKSSGQWQTPGATRSLS 80
P P N +SG +T GS + YSC + +SR C+ +G W S S
Sbjct: 2829 PGVPPNAVLSGEKYTF------GSTVHYSCTGKRSLLGQSSRTCQLNGHW-------SGS 2875
Query: 81 KAVCK---PVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMW 137
+ C C P + +G + + ++ V + C+ G+IL GS R C NG W
Sbjct: 2876 QPHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSW 2933
Query: 138 DGETAVCDNGAGHCPNPGISL-GAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV 196
G C A C NPG + G V V Y C +L+G S R+C NG
Sbjct: 2934 TGRQPECK--AVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 2991
Query: 197 WSGTEPIC 204
WSGT P C
Sbjct: 2992 WSGTLPNC 2999
Score = 71.6 bits (174), Expect = 2e-12
Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 12/163 (7%)
Query: 44 GSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102
GS ++C G + A R C SSG W S S+ C C P NG
Sbjct: 2609 GSTAIFTCDLGFMLVGSAVRECLSSGLW-------SESETRCLAGHCGIPELIVNGQVIG 2661
Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162
+Y V ++C GF L GS VR C+ + W G+ C + C +PG +
Sbjct: 2662 E--NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS--CGHPGSPIYGRT 2717
Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
+G F D V + C+ ++ G ++ +CQ N WS P+C+
Sbjct: 2718 SGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2760
Score = 67.0 bits (162), Expect = 6e-11
Identities = 56/172 (32%), Positives = 75/172 (43%), Gaps = 24/172 (13%)
Query: 60 ASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFEN-GIYTPRLGS------YPVGGN 112
++R+C++ G W S S C P S EN G+ PR GS + VG
Sbjct: 3158 STRICQADGTW-------SGSSPHCIE---PTQTSCENPGV--PRHGSQNNTFGFQVGSV 3205
Query: 113 VSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRF-GHGD 171
V F C+ G +L+GS R C P+ W G C + C P A G HG
Sbjct: 3206 VQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHS--CKQPETPAHANVVGMDLPSHGY 3263
Query: 172 KVRYRCSSNLVLTGSSE-RECQGNGVWSGTEPICRQPYSYDFPEDVAPALGT 222
+ Y C L G +E R C+ + W+G PIC + S +D PALGT
Sbjct: 3264 TLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC-EAGSKILVKDPRPALGT 3314
Score = 49.3 bits (116), Expect = 1e-05
Identities = 26/56 (46%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNG--VWSGTEPIC 204
C +PGI R GF FG GD + + CSS L G+SE C G G VWS P C
Sbjct: 1078 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1133
Score = 47.8 bits (112), Expect = 4e-05
Identities = 24/59 (40%), Positives = 29/59 (49%), Gaps = 4/59 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV----WSGTEPICR 205
C NPG+ V G RF GDK+RY C + +L G + C N V W PICR
Sbjct: 178 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236
Score = 46.6 bits (109), Expect = 9e-05
Identities = 24/79 (30%), Positives = 32/79 (40%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSY 210
C +PG L +R G F + D +R+ C L G CQ N WS PIC P
Sbjct: 560 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 619
Query: 211 DFPEDVAPALGTSFSHMLG 229
+F + L + G
Sbjct: 620 NFTAPMGTVLSPDYPEGYG 638
Score = 46.6 bits (109), Expect = 9e-05
Identities = 47/202 (23%), Positives = 73/202 (36%), Gaps = 23/202 (11%)
Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT-GSSEREC---QGNGVWSGTEP 202
G CP+PGI + A R G F G + C + T G+ C G +WSG P
Sbjct: 726 GHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 785
Query: 203 ICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCS 262
C P F L + K+SL + I+ ++ + +
Sbjct: 786 KCGAPCGGHFSAPSGVILSPGWPGYY---------KDSLNCEWVIEAEPGHSIKITFERF 836
Query: 263 QSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISS 322
Q+ D L + +L+ + S+ V F+S + + DNSR
Sbjct: 837 QTELNYDVLEVHDGPNLLSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSR-------- 887
Query: 323 LENANYKDHENGTGTNTYAALN 344
N +K H NTY+ L+
Sbjct: 888 -SNNGFKIHYESVTVNTYSCLD 908
Score = 38.5 bits (88), Expect = 0.023
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 4/59 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG----NGVWSGTEPICR 205
CP+PG R G F G V++ C + VL G+ CQ WS P+C+
Sbjct: 382 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 440
Score = 35.8 bits (81), Expect = 0.15
Identities = 19/60 (31%), Positives = 25/60 (41%), Gaps = 2/60 (3%)
Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV--WSGTEPIC 204
G CP P ++ G R+ GD V ++C L G S C V W+ PIC
Sbjct: 1944 GLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2003
Score = 34.7 bits (78), Expect = 0.33
Identities = 18/54 (33%), Positives = 23/54 (42%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
C +PGI + R G F G V + C S L+ C+ N WS P C
Sbjct: 906 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 959
Score = 34.7 bits (78), Expect = 0.33
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 6/59 (10%)
Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRPNGM--WDGETAVC 144
CP P + +GI ++G Y VG VSF+C+ G+ L+G C P + W+ +C
Sbjct: 1948 CPEPQTPSSGI---KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2003
Score = 34.3 bits (77), Expect = 0.44
Identities = 19/79 (24%), Positives = 29/79 (36%), Gaps = 3/79 (3%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC---QGNGVWSGTEPICRQP 207
C +PG+ + R G GD V ++C L G C + W + P+C P
Sbjct: 1424 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1483
Query: 208 YSYDFPEDVAPALGTSFSH 226
+ L +F H
Sbjct: 1484 CGGNLTGSSGFILSPNFPH 1502
Score = 34.3 bits (77), Expect = 0.44
Identities = 19/61 (31%), Positives = 24/61 (39%), Gaps = 4/61 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICRQ 206
C +PG + R G + G V Y C + VL G S C G W+ P C
Sbjct: 1597 CFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1656
Query: 207 P 207
P
Sbjct: 1657 P 1657
Score = 32.7 bits (73), Expect = 1.3
Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 4/45 (8%)
Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCR 132
CP P ENG R+GS + +G V F C++ ++L+G+ C+
Sbjct: 382 CPDPGEPENG---KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQ 423
Score = 32.3 bits (72), Expect = 1.7
Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 18/141 (12%)
Query: 103 RLGS-YPVGGNVSFECEDGFILRGSPVRQCR--PNGM--WDGETAVCDNGAGHCPNPGIS 157
R+G+ + VG +V F+C G+IL GS +C PN + W+ C G
Sbjct: 1785 RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG-------G 1837
Query: 158 LGAVRTGFRFGHGDKVRYRCSSNLV--LTGSSERECQGNGVWSGTEPICRQPYSYDFPED 215
+ R G G Y + N V +T Q V TE YD ++
Sbjct: 1838 ILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDN 1897
Query: 216 VAPAL----GTSFSHMLGATN 232
AP L GT+ H+L +T+
Sbjct: 1898 NAPRLGSYSGTTIPHLLNSTS 1918
Score = 32.3 bits (72), Expect = 1.7
Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 2/43 (4%)
Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQC 131
CP P F NG + VG +SFEC G+ L G+ C
Sbjct: 2120 CPDPRPFRNGFVIGN--DFTVGQTISFECFPGYTLIGNSALTC 2160
Score = 30.8 bits (68), Expect = 4.8
Identities = 12/39 (30%), Positives = 16/39 (41%)
Query: 107 YPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCD 145
+ +G VSF C+ G+ L C N W CD
Sbjct: 922 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD 960
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 96.3 bits (238), Expect = 9e-20
Identities = 57/172 (33%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 36 TLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVS 94
T +G+ ++T+SC G L P C+++ QW P +CK V C P
Sbjct: 2886 TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP-------PPMCKVVNCSDPGI 2938
Query: 95 FENGIYTPRL--GSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCP 152
N ++ G++ G V ++C G+ L GS V C+PNG WD C C
Sbjct: 2939 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI--MIDCG 2996
Query: 153 NPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
+PG+ AV +G ++ G V Y C+ L G S R CQ NG WSG++P C
Sbjct: 2997 HPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 3048
Score = 82.8 bits (203), Expect = 1e-15
Identities = 59/192 (30%), Positives = 77/192 (40%), Gaps = 21/192 (10%)
Query: 20 SAPSCPQNVN----ISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRL-CKSSGQWQTPG 74
S P P N I G FT G+++ Y C G + +S L C+ +GQW P
Sbjct: 2934 SDPGIPANSKRESKIEHGNFTY------GTVVFYDCNPGYFLFGSSVLICQPNGQWDKP- 2986
Query: 75 ATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPN 134
C + C P N + + Y G V + C L G R C+ N
Sbjct: 2987 ------LPECIMIDCGHPGVPPNAVLSGE--KYTFGSTVHYSCTGKRSLLGQSSRTCQLN 3038
Query: 135 GMWDGETAVCDNGA-GHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG 193
G W G C A G C +PG R F VRY C + +L GS ER C
Sbjct: 3039 GHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 3098
Query: 194 NGVWSGTEPICR 205
NG W+G +P C+
Sbjct: 3099 NGSWTGRQPECK 3110
Score = 82.4 bits (202), Expect = 1e-15
Identities = 52/167 (31%), Positives = 71/167 (42%), Gaps = 14/167 (8%)
Query: 44 GSLLTYSCPQGL---YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIY 100
G ++Y C G R C +G W T C+ V CP P NG
Sbjct: 3192 GQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPT-------CRAVTCPTPPQISNGRL 3244
Query: 101 TPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA 160
++ G ++S+ C G+ L V C NG W GE C C +PGI
Sbjct: 3245 EGT--NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL--PKFCGDPGIPAQG 3300
Query: 161 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP 207
R G F + +V + C+ +L GSS R CQ +G WSG+ P C +P
Sbjct: 3301 KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEP 3347
Score = 80.5 bits (197), Expect = 5e-15
Identities = 59/196 (30%), Positives = 83/196 (42%), Gaps = 19/196 (9%)
Query: 19 DSAPSCPQNVNISGGTFTLSHG---------WAPGSLLTYSCPQGLYP-SPASRLCKSSG 68
+ P C S +F L HG + + + +SC G + PAS C +G
Sbjct: 2684 NKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNG 2743
Query: 69 QWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPV 128
W + C+ + C + NG SY G F C+ GF+L GS V
Sbjct: 2744 TWSWRN-----ERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAV 2796
Query: 129 RQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE 188
R+C +G+W C AGHC P + + G +G+ D V Y+C+ L GSS
Sbjct: 2797 RECLSSGLWSESETRCL--AGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSV 2854
Query: 189 RECQGNGVWSGTEPIC 204
R CQ + WSG P C
Sbjct: 2855 RICQQDHNWSGQLPSC 2870
Score = 80.5 bits (197), Expect = 5e-15
Identities = 61/186 (32%), Positives = 79/186 (42%), Gaps = 24/186 (12%)
Query: 30 ISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVR 88
I G TF+ S + YSC +G + P+ R C ++G W S + C +
Sbjct: 3128 IDGTTFSSS--------VIYSCMEGYILSGPSVRQCTANGTW-------SGTLPNCTIIS 3172
Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFI--LRGSPVRQCRPNGMWDGETAVCD 145
C P NG+ R G Y VG NVS+ C+ G+ L GS +R C NG W G C
Sbjct: 3173 CGDPGIPANGL---RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3229
Query: 146 NGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
A CP P G F G + Y CS L+ + C GNG WSG P C
Sbjct: 3230 --AVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3287
Query: 206 QPYSYD 211
+ D
Sbjct: 3288 PKFCGD 3293
Score = 77.4 bits (189), Expect = 4e-14
Identities = 59/188 (31%), Positives = 80/188 (42%), Gaps = 22/188 (11%)
Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCP-QGLYPSPASRLCKSSGQWQTPGATRSLS 80
P P N +SG +T GS + YSC + +SR C+ +G W S S
Sbjct: 2998 PGVPPNAVLSGEKYTF------GSTVHYSCTGKRSLLGQSSRTCQLNGHW-------SGS 3044
Query: 81 KAVCK---PVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMW 137
+ C C P + +G + + ++ V + C+ G+IL GS R C NG W
Sbjct: 3045 QPHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSW 3102
Query: 138 DGETAVCDNGAGHCPNPGISL-GAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV 196
G C A C NPG + G V V Y C +L+G S R+C NG
Sbjct: 3103 TGRQPECK--AVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 3160
Query: 197 WSGTEPIC 204
WSGT P C
Sbjct: 3161 WSGTLPNC 3168
Score = 71.6 bits (174), Expect = 2e-12
Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 12/163 (7%)
Query: 44 GSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102
GS ++C G + A R C SSG W S S+ C C P NG
Sbjct: 2778 GSTAIFTCDLGFMLVGSAVRECLSSGLW-------SESETRCLAGHCGIPELIVNGQVIG 2830
Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162
+Y V ++C GF L GS VR C+ + W G+ C + C +PG +
Sbjct: 2831 E--NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS--CGHPGSPIYGRT 2886
Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
+G F D V + C+ ++ G ++ +CQ N WS P+C+
Sbjct: 2887 SGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2929
Score = 67.0 bits (162), Expect = 6e-11
Identities = 56/172 (32%), Positives = 75/172 (43%), Gaps = 24/172 (13%)
Query: 60 ASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFEN-GIYTPRLGS------YPVGGN 112
++R+C++ G W S S C P S EN G+ PR GS + VG
Sbjct: 3327 STRICQADGTW-------SGSSPHCIE---PTQTSCENPGV--PRHGSQNNTFGFQVGSV 3374
Query: 113 VSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRF-GHGD 171
V F C+ G +L+GS R C P+ W G C + C P A G HG
Sbjct: 3375 VQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHS--CKQPETPAHANVVGMDLPSHGY 3432
Query: 172 KVRYRCSSNLVLTGSSE-RECQGNGVWSGTEPICRQPYSYDFPEDVAPALGT 222
+ Y C L G +E R C+ + W+G PIC + S +D PALGT
Sbjct: 3433 TLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC-EAGSKILVKDPRPALGT 3483
Score = 49.3 bits (116), Expect = 1e-05
Identities = 26/56 (46%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNG--VWSGTEPIC 204
C +PGI R GF FG GD + + CSS L G+SE C G G VWS P C
Sbjct: 1182 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1237
Score = 47.8 bits (112), Expect = 4e-05
Identities = 24/59 (40%), Positives = 29/59 (49%), Gaps = 4/59 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV----WSGTEPICR 205
C NPG+ V G RF GDK+RY C + +L G + C N V W PICR
Sbjct: 178 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236
Score = 46.6 bits (109), Expect = 9e-05
Identities = 24/79 (30%), Positives = 32/79 (40%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSY 210
C +PG L +R G F + D +R+ C L G CQ N WS PIC P
Sbjct: 664 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 723
Query: 211 DFPEDVAPALGTSFSHMLG 229
+F + L + G
Sbjct: 724 NFTAPMGTVLSPDYPEGYG 742
Score = 46.6 bits (109), Expect = 9e-05
Identities = 47/202 (23%), Positives = 73/202 (36%), Gaps = 23/202 (11%)
Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT-GSSEREC---QGNGVWSGTEP 202
G CP+PGI + A R G F G + C + T G+ C G +WSG P
Sbjct: 830 GHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 889
Query: 203 ICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCS 262
C P F L + K+SL + I+ ++ + +
Sbjct: 890 KCGAPCGGHFSAPSGVILSPGWPGYY---------KDSLNCEWVIEAEPGHSIKITFERF 940
Query: 263 QSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISS 322
Q+ D L + +L+ + S+ V F+S + + DNSR
Sbjct: 941 QTELNYDVLEVHDGPNLLSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSR-------- 991
Query: 323 LENANYKDHENGTGTNTYAALN 344
N +K H NTY+ L+
Sbjct: 992 -SNNGFKIHYESVTVNTYSCLD 1012
Score = 38.5 bits (88), Expect = 0.023
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 4/59 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG----NGVWSGTEPICR 205
CP+PG R G F G V++ C + VL G+ CQ WS P+C+
Sbjct: 486 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544
Score = 35.8 bits (81), Expect = 0.15
Identities = 19/60 (31%), Positives = 25/60 (41%), Gaps = 2/60 (3%)
Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV--WSGTEPIC 204
G CP P ++ G R+ GD V ++C L G S C V W+ PIC
Sbjct: 2048 GLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2107
Score = 34.7 bits (78), Expect = 0.33
Identities = 18/54 (33%), Positives = 23/54 (42%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
C +PGI + R G F G V + C S L+ C+ N WS P C
Sbjct: 1010 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1063
Score = 34.7 bits (78), Expect = 0.33
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 6/59 (10%)
Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRPNGM--WDGETAVC 144
CP P + +GI ++G Y VG VSF+C+ G+ L+G C P + W+ +C
Sbjct: 2052 CPEPQTPSSGI---KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2107
Score = 34.3 bits (77), Expect = 0.44
Identities = 19/79 (24%), Positives = 29/79 (36%), Gaps = 3/79 (3%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC---QGNGVWSGTEPICRQP 207
C +PG+ + R G GD V ++C L G C + W + P+C P
Sbjct: 1528 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1587
Query: 208 YSYDFPEDVAPALGTSFSH 226
+ L +F H
Sbjct: 1588 CGGNLTGSSGFILSPNFPH 1606
Score = 34.3 bits (77), Expect = 0.44
Identities = 19/61 (31%), Positives = 24/61 (39%), Gaps = 4/61 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICRQ 206
C +PG + R G + G V Y C + VL G S C G W+ P C
Sbjct: 1701 CFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1760
Query: 207 P 207
P
Sbjct: 1761 P 1761
Score = 32.7 bits (73), Expect = 1.3
Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 4/45 (8%)
Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCR 132
CP P ENG R+GS + +G V F C++ ++L+G+ C+
Sbjct: 486 CPDPGEPENG---KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQ 527
Score = 32.3 bits (72), Expect = 1.7
Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 18/141 (12%)
Query: 103 RLGS-YPVGGNVSFECEDGFILRGSPVRQCR--PNGM--WDGETAVCDNGAGHCPNPGIS 157
R+G+ + VG +V F+C G+IL GS +C PN + W+ C G
Sbjct: 1889 RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG-------G 1941
Query: 158 LGAVRTGFRFGHGDKVRYRCSSNLV--LTGSSERECQGNGVWSGTEPICRQPYSYDFPED 215
+ R G G Y + N V +T Q V TE YD ++
Sbjct: 1942 ILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDN 2001
Query: 216 VAPAL----GTSFSHMLGATN 232
AP L GT+ H+L +T+
Sbjct: 2002 NAPRLGSYSGTTIPHLLNSTS 2022
Score = 32.3 bits (72), Expect = 1.7
Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 2/43 (4%)
Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQC 131
CP P F NG + VG +SFEC G+ L G+ C
Sbjct: 2224 CPDPRPFRNGFVIGN--DFTVGQTISFECFPGYTLIGNSALTC 2264
Score = 30.8 bits (68), Expect = 4.8
Identities = 12/39 (30%), Positives = 16/39 (41%)
Query: 107 YPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCD 145
+ +G VSF C+ G+ L C N W CD
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD 1064
>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
sapiens]
Length = 432
Score = 83.2 bits (204), Expect = 8e-16
Identities = 70/252 (27%), Positives = 105/252 (41%), Gaps = 38/252 (15%)
Query: 451 HMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFR 510
H L K T VG A+ + PW V+I+ Q C G+++ WVLTAAHCFR
Sbjct: 187 HCLACGKSLKTPRVVGGEEASV---DSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR 243
Query: 511 DGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQK 570
D W+V G K + K +I ++ K N DIAL+KL
Sbjct: 244 KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN---------DIALMKLQFP 294
Query: 571 VKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLK 630
+ S RPICLP + EL + P + +K N
Sbjct: 295 LTFSGTVRPICLPF------------------FDEEL--TPATPLWIIGWGFTKQNGGKM 334
Query: 631 MGVEWTSCAEVVSQEKTMFPNLTDVRE-VVTDQFLCSGTQE-DESPCKGESGGAVFLERR 688
+ + +V+ + N D + VT++ +C+G E C+G+SGG + +
Sbjct: 335 SDILLQASVQVIDSTRC---NADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD 391
Query: 689 FRFFQVGLVSWG 700
++ VG+VSWG
Sbjct: 392 -QWHVVGIVSWG 402
>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
sapiens]
Length = 437
Score = 83.2 bits (204), Expect = 8e-16
Identities = 70/252 (27%), Positives = 105/252 (41%), Gaps = 38/252 (15%)
Query: 451 HMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFR 510
H L K T VG A+ + PW V+I+ Q C G+++ WVLTAAHCFR
Sbjct: 192 HCLACGKSLKTPRVVGGEEASV---DSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR 248
Query: 511 DGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQK 570
D W+V G K + K +I ++ K N DIAL+KL
Sbjct: 249 KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN---------DIALMKLQFP 299
Query: 571 VKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLK 630
+ S RPICLP + EL + P + +K N
Sbjct: 300 LTFSGTVRPICLPF------------------FDEEL--TPATPLWIIGWGFTKQNGGKM 339
Query: 631 MGVEWTSCAEVVSQEKTMFPNLTDVRE-VVTDQFLCSGTQE-DESPCKGESGGAVFLERR 688
+ + +V+ + N D + VT++ +C+G E C+G+SGG + +
Sbjct: 340 SDILLQASVQVIDSTRC---NADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD 396
Query: 689 FRFFQVGLVSWG 700
++ VG+VSWG
Sbjct: 397 -QWHVVGIVSWG 407
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 82.0 bits (201), Expect = 2e-15
Identities = 65/203 (32%), Positives = 91/203 (44%), Gaps = 29/203 (14%)
Query: 8 FCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSC-PQGLYPSPASRLCKS 66
FC+L ++ P P + +SG ++T+ G+++ YSC + ++R+C
Sbjct: 2768 FCVL-----VSCGHPGSPPHSQMSGDSYTV------GAVVRYSCIGKRTLVGNSTRMCGL 2816
Query: 67 SGQW--QTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLG-SYPVGGNVSFECEDGFIL 123
G W P + + S VC PA +GI RLG S+ G + F CE G +L
Sbjct: 2817 DGHWTGSLPHCSGT-SVGVCGDPGIPA-----HGI---RLGDSFDPGTVMRFSCEAGHVL 2867
Query: 124 RGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFG--HGDKVRYRCSSNL 181
RGS R C+ NG W G C G C NPG A R F G + Y C
Sbjct: 2868 RGSSERTCQANGSWSGSQPEC--GVISCGNPGTPSNA-RVVFSDGLVFSSSIVYECREGY 2924
Query: 182 VLTGSSERECQGNGVWSGTEPIC 204
TG R C NG W+G++P C
Sbjct: 2925 YATGLLSRHCSVNGTWTGSDPEC 2947
Score = 81.6 bits (200), Expect = 2e-15
Identities = 55/160 (34%), Positives = 70/160 (43%), Gaps = 11/160 (6%)
Query: 47 LTYSCPQGLYPSPAS-RLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLG 105
+ Y C G S R+C+ W G T C V C P S + +
Sbjct: 2738 VVYQCNAGFRLIGMSVRICQQDHHWS--GKT-----PFCVLVSCGHPGSPPHSQMSG--D 2788
Query: 106 SYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDN-GAGHCPNPGISLGAVRTG 164
SY VG V + C L G+ R C +G W G C G C +PGI +R G
Sbjct: 2789 SYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLG 2848
Query: 165 FRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
F G +R+ C + VL GSSER CQ NG WSG++P C
Sbjct: 2849 DSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPEC 2888
Score = 80.5 bits (197), Expect = 5e-15
Identities = 58/188 (30%), Positives = 80/188 (42%), Gaps = 11/188 (5%)
Query: 47 LTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGS 106
+TY C G Y + R+ S T T + +K VCK + C P NG
Sbjct: 2974 VTYQCVPG-YMMESHRVSVLSC---TKDRTWNGTKPVCKALMCKPPPLIPNGKVVG--SD 3027
Query: 107 YPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFR 166
+ G +V++ C +G+ L V C NG W GE C C +PG+ R
Sbjct: 3028 FMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCF--PVFCGDPGVPSRGRREDRG 3085
Query: 167 FGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALG---TS 223
F + V + C LVL GS R CQ +G WSGT+P C P + P G S
Sbjct: 3086 FSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNS 3145
Query: 224 FSHMLGAT 231
+ +G+T
Sbjct: 3146 QGYQVGST 3153
Score = 77.4 bits (189), Expect = 4e-14
Identities = 46/142 (32%), Positives = 66/142 (46%), Gaps = 11/142 (7%)
Query: 64 CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPV-GGNVSFECEDGFI 122
C+++G+W +T + C+ + C NG R+G+ V G F C G+
Sbjct: 2638 CQANGKWSLGDSTPT-----CRIISCGELPIPPNG---HRIGTLSVYGATAIFSCNSGYT 2689
Query: 123 LRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLV 182
L GS VR+C NG+W G C AGHC P + G + + V Y+C++
Sbjct: 2690 LVGSRVRECMANGLWSGSEVRCL--AGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFR 2747
Query: 183 LTGSSERECQGNGVWSGTEPIC 204
L G S R CQ + WSG P C
Sbjct: 2748 LIGMSVRICQQDHHWSGKTPFC 2769
Score = 72.8 bits (177), Expect = 1e-12
Identities = 51/198 (25%), Positives = 87/198 (43%), Gaps = 24/198 (12%)
Query: 20 SAPSCP-QNVNISGGTFTLSHG------WAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQ 71
S P C +V + G +HG + PG+++ +SC G + + R C+++G W
Sbjct: 2823 SLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSW- 2881
Query: 72 TPGATRSLSKAVCKPVRCPAPVSFENG--IYTPRLGSYPVGGNVSFECEDGFILRGSPVR 129
S S+ C + C P + N +++ L ++ +EC +G+ G R
Sbjct: 2882 ------SGSQPECGVISCGNPGTPSNARVVFSDGL---VFSSSIVYECREGYYATGLLSR 2932
Query: 130 QCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS--S 187
C NG W G C +C +PGI +R G F + V Y+C ++ S
Sbjct: 2933 HCSVNGTWTGSDPECL--VINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVS 2990
Query: 188 ERECQGNGVWSGTEPICR 205
C + W+GT+P+C+
Sbjct: 2991 VLSCTKDRTWNGTKPVCK 3008
Score = 71.2 bits (173), Expect = 3e-12
Identities = 56/201 (27%), Positives = 82/201 (40%), Gaps = 23/201 (11%)
Query: 13 LYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLY---PSPASRLCKSSGQ 69
L L+ P P+N + G +T+ G+ YSC +G + + A+ C +G
Sbjct: 2525 LCQALSCGLPEAPKNGMVFGKEYTV------GTKAMYSCSEGYHLQAGAEATAECLDTGL 2578
Query: 70 WQTPGATRSLSKAVCKPVRCP--APVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGS 126
W C PV CP + +S E+G + + Y + C+ G+ G
Sbjct: 2579 WSNRNVPPQ-----CVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQ 2633
Query: 127 PVRQCRPNGMWD--GETAVCD-NGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVL 183
V +C+ NG W T C G P P R G +G + C+S L
Sbjct: 2634 RVIRCQANGKWSLGDSTPTCRIISCGELPIPP---NGHRIGTLSVYGATAIFSCNSGYTL 2690
Query: 184 TGSSERECQGNGVWSGTEPIC 204
GS REC NG+WSG+E C
Sbjct: 2691 VGSRVRECMANGLWSGSEVRC 2711
Score = 70.1 bits (170), Expect = 7e-12
Identities = 57/172 (33%), Positives = 74/172 (43%), Gaps = 18/172 (10%)
Query: 40 GWAPGSLLTYSC--PQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFEN 97
G++ S +++SC P L SP R C+S G W G S P F
Sbjct: 3085 GFSYRSSVSFSCHPPLVLVGSPR-RFCQSDGTWS--GTQPSCIDPTLTTCADPGVPQF-- 3139
Query: 98 GIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNP--- 154
GI G Y VG V F C+ G++L+GS R C PN W G C HC P
Sbjct: 3140 GIQNNSQG-YQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDC--VPHHCRQPETP 3196
Query: 155 -GISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE-RECQGNGVWSGTEPIC 204
++GA+ G + Y C L G SE R C+ +G W+G PIC
Sbjct: 3197 THANVGALDLP---SMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPIC 3245
Score = 49.7 bits (117), Expect = 1e-05
Identities = 25/81 (30%), Positives = 34/81 (41%)
Query: 149 GHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPY 208
G C +PGI R G RF HGD +++ C L G CQ N WS +P C
Sbjct: 519 GSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSC 578
Query: 209 SYDFPEDVAPALGTSFSHMLG 229
++F L ++ G
Sbjct: 579 FFNFTSPSGVVLSPNYPEDYG 599
Score = 44.3 bits (103), Expect = 4e-04
Identities = 26/63 (41%), Positives = 31/63 (49%), Gaps = 4/63 (6%)
Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCR--PNGMWDGETAVCDN 146
CP P F NGI R Y VG +V+FEC G+ L G PV C+ N WD C+
Sbjct: 2123 CPDPEPFANGIV--RGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEV 2180
Query: 147 GAG 149
G
Sbjct: 2181 PCG 2183
Score = 40.4 bits (93), Expect = 0.006
Identities = 20/55 (36%), Positives = 25/55 (45%)
Query: 150 HCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
HC +PGI + R G F G V + C S L+ EC+ N WS P C
Sbjct: 866 HCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSC 920
Score = 39.7 bits (91), Expect = 0.010
Identities = 32/116 (27%), Positives = 46/116 (39%), Gaps = 9/116 (7%)
Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQC--RPNG--MWDGETAVC 144
C P + +G + + P GG++ F C G+ L G + C P G +W +C
Sbjct: 2468 CSLPRAPLHGFILGQTSTQP-GGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLC 2526
Query: 145 DNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE--RECQGNGVWS 198
A C P + G + G K Y CS L +E EC G+WS
Sbjct: 2527 Q--ALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWS 2580
Score = 39.3 bits (90), Expect = 0.014
Identities = 20/59 (33%), Positives = 26/59 (44%), Gaps = 4/59 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICR 205
C NPG ++ G F GDKVRY C+ L G + C + + W P CR
Sbjct: 139 CGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCR 197
Score = 38.5 bits (88), Expect = 0.023
Identities = 21/63 (33%), Positives = 26/63 (41%), Gaps = 4/63 (6%)
Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG----NGVWSGTEP 202
G CP+PGI R G F G V++ C+ L GS C WS P
Sbjct: 339 GHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRP 398
Query: 203 ICR 205
+CR
Sbjct: 399 VCR 401
Score = 38.1 bits (87), Expect = 0.030
Identities = 18/60 (30%), Positives = 26/60 (43%), Gaps = 2/60 (3%)
Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV--WSGTEPIC 204
G CP P + V+TG R+ D V ++C L G + C V W+ P+C
Sbjct: 1905 GLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC 1964
Score = 37.0 bits (84), Expect = 0.067
Identities = 18/35 (51%), Positives = 22/35 (62%), Gaps = 1/35 (2%)
Query: 100 YTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRP 133
Y RLGS + VG V FEC G+ L+GSP +C P
Sbjct: 1743 YGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLP 1777
Score = 36.6 bits (83), Expect = 0.088
Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 3/67 (4%)
Query: 148 AGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC---QGNGVWSGTEPIC 204
A C +PGI R+G + GD ++C L GS+E C + W + P C
Sbjct: 1382 ATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTC 1441
Query: 205 RQPYSYD 211
P D
Sbjct: 1442 IAPCGGD 1448
Score = 35.8 bits (81), Expect = 0.15
Identities = 19/67 (28%), Positives = 25/67 (37%), Gaps = 4/67 (5%)
Query: 145 DNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGT 200
+N C +PG R G G V Y C + G+S C G VW+
Sbjct: 1552 ENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNP 1611
Query: 201 EPICRQP 207
P+C P
Sbjct: 1612 RPVCTAP 1618
Score = 35.4 bits (80), Expect = 0.20
Identities = 17/56 (30%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG--NGVWSGTEPIC 204
C P + ++R G +FG GD + + C L G++ C G +WS P C
Sbjct: 1039 CEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRC 1094
Score = 35.0 bits (79), Expect = 0.26
Identities = 20/58 (34%), Positives = 27/58 (46%), Gaps = 4/58 (6%)
Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGM--WDGETAVC 144
CP P NG+ T Y V VSF+CE G+ L+G C P + W+ +C
Sbjct: 1909 CPEPAVPSNGVKTGE--RYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC 1964
Score = 34.3 bits (77), Expect = 0.44
Identities = 29/92 (31%), Positives = 35/92 (38%), Gaps = 5/92 (5%)
Query: 162 RTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICRQPYSYDFPEDVA 217
R G F G VR+ C+S L GS E EC W+ + P C P + E
Sbjct: 1746 RLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRG 1805
Query: 218 PALGTSFSH-MLGATNPTQKTKESLGRKIQIQ 248
L F L + N K G IQIQ
Sbjct: 1806 TILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQ 1837
Score = 32.3 bits (72), Expect = 1.7
Identities = 17/67 (25%), Positives = 28/67 (41%), Gaps = 5/67 (7%)
Query: 88 RCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNG--MWDGETAVCD 145
+CP P N + +G V + C GF L G+ + C+ ++G +C+
Sbjct: 2293 KCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICE 2352
Query: 146 NGAGHCP 152
HCP
Sbjct: 2353 ---VHCP 2356
Score = 31.6 bits (70), Expect = 2.8
Identities = 12/37 (32%), Positives = 17/37 (45%)
Query: 109 VGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCD 145
VG V+F C+ G+ L +C PN W C+
Sbjct: 885 VGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCE 921
Score = 31.2 bits (69), Expect = 3.7
Identities = 37/173 (21%), Positives = 63/173 (36%), Gaps = 13/173 (7%)
Query: 136 MWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQ--G 193
+WD + CP+P + G + G V + C LTG CQ
Sbjct: 2108 VWDLDPGCEAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGT 2167
Query: 194 NGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGR-KIQIQRSGH 252
N W P C P ++ + GT +S G +P +++ + + I
Sbjct: 2168 NRNWDHPLPKCEVPCG----GNITSSNGTVYSP--GFPSPYSSSQDCVWLITVPIGHGVR 2221
Query: 253 LNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVL 305
LNL LL Q+ DF+ + R+ F +++ + +S +L
Sbjct: 2222 LNLSLL----QTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLL 2270
Score = 30.8 bits (68), Expect = 4.8
Identities = 17/61 (27%), Positives = 26/61 (42%), Gaps = 4/61 (6%)
Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT-GSSEREC---QGNGVWSGTEPICRQ 206
CP+PG+ + R G G + + C + T GS C +G+ VW+ C
Sbjct: 691 CPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCEA 750
Query: 207 P 207
P
Sbjct: 751 P 751
Score = 30.4 bits (67), Expect = 6.3
Identities = 21/58 (36%), Positives = 24/58 (41%), Gaps = 4/58 (6%)
Query: 151 CPNPGISLGA--VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV--WSGTEPIC 204
CP P I A V F GD VRYRC L G+ C+ + G PIC
Sbjct: 2294 CPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPIC 2351
Score = 30.0 bits (66), Expect = 8.2
Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 4/44 (9%)
Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQC 131
CP P E G RLGS + +G +V F C +G+ L+GS C
Sbjct: 343 CPDPGIPERG---KRLGSDFRLGSSVQFTCNEGYDLQGSKRITC 383
>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
Length = 318
Score = 81.6 bits (200), Expect = 2e-15
Identities = 62/248 (25%), Positives = 110/248 (44%), Gaps = 56/248 (22%)
Query: 473 SDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQ---- 528
S + R PW +++ + + C G+L+S +WVL+AAHCF+ S W V +G+ S+
Sbjct: 61 SARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPW 120
Query: 529 ----WGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICL-- 582
+ + ++ +++P G+L +DIALL+LA V + + +PIC+
Sbjct: 121 NLRAYSSRYKVQDIIVNP-------DALGVLR---NDIALLRLASSVTYNAYIQPICIES 170
Query: 583 --------PCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVE 634
P L P G+ N L +++ I +
Sbjct: 171 STFNFVHRPDCWVTGWGLISPSGTPLPPPYN--------------LREAQVTI-----LN 211
Query: 635 WTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDE-SPCKGESGGAVFLERRFRFFQ 693
T C + Q + R ++ D C+G ++ CKG+SGG + ++ ++Q
Sbjct: 212 NTRCNYLFEQPSS--------RSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQ 263
Query: 694 VGLVSWGL 701
VG+VSWG+
Sbjct: 264 VGIVSWGM 271
>gi|148231605 ovochymase 2 [Homo sapiens]
Length = 564
Score = 81.6 bits (200), Expect = 2e-15
Identities = 74/271 (27%), Positives = 118/271 (43%), Gaps = 42/271 (15%)
Query: 479 PWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGD---PKSQWGKEFL- 534
PW V++K + + C G+++S QWV+TAAHC + N S V G+ ++ G++ L
Sbjct: 64 PWQVSLKQRQKHICGGSIVSPQWVITAAHCIANRNIVSTLNVTAGEYDLSQTDPGEQTLT 123
Query: 535 IEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRR 594
IE +I P F KK DIALLK+A + PICLP L +
Sbjct: 124 IETVIIHPHFS--TKKPMDY------DIALLKMAGAFQFGHFVGPICLP-----ELREQF 170
Query: 595 PQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTD 654
G C L + V L+ +NL + + W C + LT
Sbjct: 171 EAGFICTTAGWGRLTEGGV------LSQVLQEVNLPI-LTWEECVAAL---------LTL 214
Query: 655 VREVVTDQFLCSGTQE-DESPCKGESGGAVFL-ERRFRFFQVGLVSWGLYNPCLGSADKN 712
R + FLC+G + C+G+SGG++ ++ + G+ SWGL +
Sbjct: 215 KRPISGKTFLCTGFPDGGRDACQGDSGGSLMCRNKKGAWTLAGVTSWGL------GCGRG 268
Query: 713 SRKRAPRSKVPPPRDFHINLFRMQPWLRQHL 743
R +S P F ++ ++ PW+ +H+
Sbjct: 269 WRNNVRKSDQGSPGIF-TDISKVLPWIHEHI 298
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 80.1 bits (196), Expect = 7e-15
Identities = 57/193 (29%), Positives = 81/193 (41%), Gaps = 25/193 (12%)
Query: 25 PQNVNIS-----GGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRS 78
PQN ++ G FT S ++C +G + PA C + GQW T+
Sbjct: 310 PQNGSVRCSHSPAGEFTFK------SSCNFTCEEGFMLQGPAQVECTTQGQW-----TQQ 358
Query: 79 LSKAVCKPVRCPAPVSFENGIYT---PRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNG 135
+ VC+ +C A + E G GS+ G + F CE GF+L+GS QC P G
Sbjct: 359 IP--VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTG 416
Query: 136 MWDGETAVCDN---GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQ 192
WD E C+ A H P G+ A F + + C L GS++ EC
Sbjct: 417 EWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECT 476
Query: 193 GNGVWSGTEPICR 205
G W+ P C+
Sbjct: 477 SQGQWTEEVPSCQ 489
Score = 76.3 bits (186), Expect = 1e-13
Identities = 56/200 (28%), Positives = 78/200 (39%), Gaps = 22/200 (11%)
Query: 20 SAPSCPQNVNISG------GTFTLSH---GWAPGSLLTYSCPQGLYPSPASRL-CKSSGQ 69
S C Q VN + G+ SH ++ S + SC +G PS + C SSG+
Sbjct: 170 SGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE 229
Query: 70 WQTPGATRSLSKAVCKPVRCPAPVSFENGIYT--PRLGSYPVGGNVSFECEDGFILRGSP 127
W P C V C A + NG GS+P +F+CE+GF L G+
Sbjct: 230 WSAP-------IPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ 282
Query: 128 VRQCRPNGMWDGETAVCDN---GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT 184
QC +G WD E C A P G + F + C +L
Sbjct: 283 SLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQ 342
Query: 185 GSSERECQGNGVWSGTEPIC 204
G ++ EC G W+ P+C
Sbjct: 343 GPAQVECTTQGQWTQQIPVC 362
Score = 72.4 bits (176), Expect = 1e-12
Identities = 50/177 (28%), Positives = 70/177 (39%), Gaps = 18/177 (10%)
Query: 44 GSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPA----PVSFENG 98
GS +SC QG + RL C +G+W K C+ VRC A P
Sbjct: 391 GSSCEFSCEQGFVLKGSKRLQCGPTGEWDN-------EKPTCEAVRCDAVHQPPKGLVRC 443
Query: 99 IYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISL 158
++P +G + + +F CE+GF L GS +C G W E C C + +
Sbjct: 444 AHSP-IGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQ--VVKCSSLAVP- 499
Query: 159 GAVRTGFRFG--HGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFP 213
G + G ++ C L GS+ R C G WSG P C P + P
Sbjct: 500 GKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIP 556
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/133 (23%), Positives = 48/133 (36%), Gaps = 24/133 (18%)
Query: 87 VRCPAPVSFENG--IYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVC 144
V C A S E+G + + LG++ + S C+ G++ QC +G W C
Sbjct: 178 VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC 237
Query: 145 D-----------NGAGHC-PNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQ 192
+ NG C NPG F + C L G+ +C
Sbjct: 238 NVVECDAVTNPANGFVECFQNPG----------SFPWNTTCTFDCEEGFELMGAQSLQCT 287
Query: 193 GNGVWSGTEPICR 205
+G W +P C+
Sbjct: 288 SSGNWDNEKPTCK 300
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 78.2 bits (191), Expect = 3e-14
Identities = 72/252 (28%), Positives = 117/252 (46%), Gaps = 47/252 (18%)
Query: 463 CGVGNMSAN-----ASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHS- 516
CG+ S+ S + PW +++ + + C GALI+D+WV+TAAHCF++ + S
Sbjct: 568 CGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMAST 627
Query: 517 -LWRVNVGD--PKSQWGKE--FLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKV 571
LW V +G S+W E F + + ++ P + + + D+ALL+L V
Sbjct: 628 VLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEE---------DSHDYDVALLQLDHPV 678
Query: 572 KMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKM 631
S RP+CLP A P G C L + ++ + K+++ L
Sbjct: 679 VRSAAVRPVCLP----ARSHFFEP-GLHCWITGWGALREGGPISNAL----QKVDVQL-- 727
Query: 632 GVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQE-DESPCKGESGGAVFLER-RF 689
+ C+EV R VT + LC+G ++ + C+G+SGG + +
Sbjct: 728 -IPQDLCSEV-------------YRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSG 773
Query: 690 RFFQVGLVSWGL 701
R+F GLVSWGL
Sbjct: 774 RWFLAGLVSWGL 785
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 76.6 bits (187), Expect = 8e-14
Identities = 52/170 (30%), Positives = 71/170 (41%), Gaps = 10/170 (5%)
Query: 44 GSLLTYSCPQGL-YPSPASRLCKSSGQWQ-TPGATRSLSKAVCKPVRCPAPVSFENGIYT 101
GS +SC G P + C +SG+W TP + ++ V+CPA + G
Sbjct: 595 GSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMY 654
Query: 102 PRLGSYPVGGNVS--FECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCP----NPG 155
R G N + F C GF L G CRP+G W T C A C N
Sbjct: 655 CRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACR--AVKCSELHVNKP 712
Query: 156 ISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
I++ F +G + C +L GS++ CQ NG WS T P C+
Sbjct: 713 IAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
Score = 68.9 bits (167), Expect = 2e-11
Identities = 55/199 (27%), Positives = 78/199 (39%), Gaps = 15/199 (7%)
Query: 15 PGLADSAPSCPQNVNISGGTFTLSH---GWAPGSLLTYSCPQGLYPSPASRL-CKSSGQW 70
P A C S GT H +A GS + C G L C SG W
Sbjct: 315 PAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHW 374
Query: 71 QTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQ 130
P T C+P+ P S + +P L ++ N SF C +GF+LRG+ + +
Sbjct: 375 SAPLPT--CEAISCEPLESPVHGSMD---CSPSLRAFQYDTNCSFRCAEGFMLRGADIVR 429
Query: 131 CRPNGMWDGETAVCDNGAGHCPN-PGISLGAVRTGFRFG---HGDKVRYRCSSNLVLTGS 186
C G W VC A C + P + V FG + + C+ L+L G+
Sbjct: 430 CDNLGQWTAPAPVCQ--ALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGA 487
Query: 187 SERECQGNGVWSGTEPICR 205
S +C G W+ P C+
Sbjct: 488 SVLQCLATGNWNSVPPECQ 506
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/185 (28%), Positives = 76/185 (41%), Gaps = 16/185 (8%)
Query: 45 SLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYT-- 101
S+ +++C +GL AS L C ++G W + C+ + C +S +NG T
Sbjct: 472 SVCSFTCNEGLLLVGASVLQCLATGNWNSVPPE-------CQAIPCTPLLSPQNGTMTCV 524
Query: 102 PRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGI----S 157
LGS F C++G+ L G C +G W +C+ A CP S
Sbjct: 525 QPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCE--AIKCPELFAPEQGS 582
Query: 158 LGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVA 217
L T F G + C + L G + EC +G WS T P C+ S P
Sbjct: 583 LDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQC 642
Query: 218 PALGT 222
PAL T
Sbjct: 643 PALTT 647
Score = 63.9 bits (154), Expect = 5e-10
Identities = 58/222 (26%), Positives = 85/222 (38%), Gaps = 25/222 (11%)
Query: 21 APSCPQNVNISGGTFTLSHG---WAPGSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGAT 76
A CP G T H + S ++SC +G P C +SG W P
Sbjct: 259 AAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAP- 317
Query: 77 RSLSKAVCKPVRCP---APVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRP 133
VCK V+C AP P L ++ G + FEC+ G+ +RG + +C
Sbjct: 318 ------VCKAVQCQHLEAPSEGTMDCVHP-LTAFAYGSSCKFECQPGYRVRGLDMLRCID 370
Query: 134 NGMWDGETAVCDNGAGHC-----PNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE 188
+G W C+ A C P G S+ + F + +RC+ +L G+
Sbjct: 371 SGHWSAPLPTCE--AISCEPLESPVHG-SMDCSPSLRAFQYDTNCSFRCAEGFMLRGADI 427
Query: 189 RECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGA 230
C G W+ P+C+ D P V + SH GA
Sbjct: 428 VRCDNLGQWTAPAPVCQALQCQDLP--VPNEARVNCSHPFGA 467
Score = 57.4 bits (137), Expect = 5e-08
Identities = 48/168 (28%), Positives = 71/168 (42%), Gaps = 18/168 (10%)
Query: 45 SLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYT-- 101
S ++ C G + S+L C +SG W T + L+ A C P++ P E G T
Sbjct: 224 SQCSFHCTDGYQVNGPSKLECLASGIW-TNKPPQCLA-AQCPPLKIP-----ERGNMTCL 276
Query: 102 PRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHC-----PNPGI 156
++ + SF CE+GF L G V QC +G+W VC A C P+ G
Sbjct: 277 HSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCK--AVQCQHLEAPSEG- 333
Query: 157 SLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204
++ V F +G ++ C + G C +G WS P C
Sbjct: 334 TMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381
Score = 55.8 bits (133), Expect = 1e-07
Identities = 27/106 (25%), Positives = 45/106 (42%), Gaps = 6/106 (5%)
Query: 104 LGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGI----SLG 159
LG++ SF C DG+ + G +C +G+W + C A CP I ++
Sbjct: 217 LGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCL--AAQCPPLKIPERGNMT 274
Query: 160 AVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205
+ + F H + C L G +C +GVW+ P+C+
Sbjct: 275 CLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCK 320
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/130 (26%), Positives = 47/130 (36%), Gaps = 13/130 (10%)
Query: 24 CPQNVNISGGTFTLSHGWAPGSL-----LTYSCPQGLYPSPASRL-CKSSGQWQTPGATR 77
CP GT H PG+ + C G S L C+ SGQW T
Sbjct: 642 CPALTTPGQGTMYCRHH--PGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTA--VTP 697
Query: 78 SLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMW 137
+ C + P++ + G++ G SF C +G +L GS C+ NG W
Sbjct: 698 ACRAVKCSELHVNKPIAMN---CSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHW 754
Query: 138 DGETAVCDNG 147
C G
Sbjct: 755 STTVPTCQAG 764
>gi|13994276 marapsin [Homo sapiens]
Length = 290
Score = 76.3 bits (186), Expect = 1e-13
Identities = 71/260 (27%), Positives = 113/260 (43%), Gaps = 53/260 (20%)
Query: 461 TICG----VGNMSANASDQE-RTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDH 515
T CG + M QE PW V+I+ C G+LI++QWVLTAAHCFR+ ++
Sbjct: 24 TACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSET 83
Query: 516 SLWRVNVG-------DPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLA 568
SL++V +G P + + + +E + G A D+AL++L
Sbjct: 84 SLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSA------------DVALVELE 131
Query: 569 QKVKMSTHARPICLP---CTMEANL-ALRRPQGSTCRDH---ENELLNKQSVPAHFVALN 621
V + + P+CLP E + GS + E +L K +VP ++
Sbjct: 132 APVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVP----IID 187
Query: 622 GSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQE-DESPCKGESG 680
K N+ ++ E Q KT + + LC+G +E + CKG+SG
Sbjct: 188 TPKCNL------LYSKDTEFGYQPKT-----------IKNDMLCAGFEEGKKDACKGDSG 230
Query: 681 GAVFLERRFRFFQVGLVSWG 700
G + + Q G++SWG
Sbjct: 231 GPLVCLVGQSWLQAGVISWG 250
>gi|4506115 protein C [Homo sapiens]
Length = 461
Score = 74.7 bits (182), Expect = 3e-13
Identities = 68/231 (29%), Positives = 99/231 (42%), Gaps = 38/231 (16%)
Query: 478 TPWHVTI-KPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPK--SQWGKEFL 534
+PW V + K + C LI WVLTAAHC D + L R+ D + +W +
Sbjct: 223 SPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCM-DESKKLLVRLGEYDLRRWEKWELDLD 281
Query: 535 IEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRR 594
I++ + P + N DIALL LAQ +S PICLP + A L +
Sbjct: 282 IKEVFVHPNYSKSTTDN---------DIALLHLAQPATLSQTIVPICLPDSGLAERELNQ 332
Query: 595 PQGSTCRD----HENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFP 650
T H + K++ LN K+ + V C+EV+S
Sbjct: 333 AGQETLVTGWGYHSSR--EKEAKRNRTFVLNFIKIPV-----VPHNECSEVMSN------ 379
Query: 651 NLTDVREVVTDQFLCSGTQED-ESPCKGESGGAVFLERRFRFFQVGLVSWG 700
+V++ LC+G D + C+G+SGG + +F VGLVSWG
Sbjct: 380 -------MVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWG 423
>gi|32698940 transmembrane protease, serine 12 [Homo sapiens]
Length = 348
Score = 74.7 bits (182), Expect = 3e-13
Identities = 62/258 (24%), Positives = 109/258 (42%), Gaps = 50/258 (19%)
Query: 458 LTDTICGVGNMSANASDQERTPWHVTIKPKSQET----CRGALISDQWVLTAAHCFRDGN 513
L D + G + + PW V+++ K C G L+ ++WVLTAAHC +D +
Sbjct: 69 LKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDAS 128
Query: 514 DHSLWRVNVG----DPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQ 569
D +W +G + K+ I+ +I P F ILE Y +DIAL L +
Sbjct: 129 DPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIHPNF---------ILESYVNDIALFHLKK 179
Query: 570 KVKMSTHARPICLPC----TMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKL 625
V+ + + +PICLP ++ N ++ N Q H+++
Sbjct: 180 AVRYNDYIQPICLPFDVFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHYIS------ 233
Query: 626 NINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDE-SPCKGESGGAV- 683
E+ + E++ ++ + C+G ++ C+G+SGG +
Sbjct: 234 -------------REMCNSERS-------YGGIIPNTSFCAGDEDGAFDTCRGDSGGPLM 273
Query: 684 -FLERRFRFFQVGLVSWG 700
+L RFF +G+ S+G
Sbjct: 274 CYLPEYKRFFVMGITSYG 291
>gi|4502495 complement component 1, s subcomponent precursor [Homo
sapiens]
Length = 688
Score = 74.3 bits (181), Expect = 4e-13
Identities = 67/239 (28%), Positives = 100/239 (41%), Gaps = 37/239 (15%)
Query: 473 SDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKE 532
+D + PW V GALI++ WVLTAAH + +++ + S+ K
Sbjct: 444 ADIKNFPWQVFF---DNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKS 500
Query: 533 FLI--EKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCT----- 585
++ E I PG+ + + +G F +DIAL++L VKM PICLP T
Sbjct: 501 KMLTPEHVFIHPGWKLL-EVPEGRTNF-DNDIALVRLKDPVKMGPTVSPICLPGTSSDYN 558
Query: 586 -MEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQ 644
M+ +L L G T + L +P C EV
Sbjct: 559 LMDGDLGLISGWGRTEKRDRAVRLKAARLPV-----------------APLRKCKEV--- 598
Query: 645 EKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLE---RRFRFFQVGLVSWG 700
K P V T +C+G ++ CKG+SGGA ++ + +F+ GLVSWG
Sbjct: 599 -KVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWG 656
Score = 39.3 bits (90), Expect = 0.014
Identities = 27/81 (33%), Positives = 36/81 (44%), Gaps = 13/81 (16%)
Query: 64 CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENG-IYTPRLGSYPVGGNVSFECEDGFI 122
C+S+G+W S SK C+PV C P S ENG + P S G + + CE+ +
Sbjct: 341 CQSNGKW-------SNSKLKCQPVDCGIPESIENGKVEDPE--STLFGSVIRYTCEEPYY 391
Query: 123 LR---GSPVRQCRPNGMWDGE 140
G C NG W E
Sbjct: 392 YMENGGGGEYHCAGNGSWVNE 412
Score = 38.5 bits (88), Expect = 0.023
Identities = 33/121 (27%), Positives = 41/121 (33%), Gaps = 11/121 (9%)
Query: 86 PVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGF-ILRG-----SPVRQCRPNGMWDG 139
P+ CP + N ++ P Y V C DGF ++ G S C+ NG W
Sbjct: 291 PMPCPKEDT-PNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSN 349
Query: 140 ETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT---GSSERECQGNGV 196
C P I G V G +RY C G E C GNG
Sbjct: 350 SKLKCQPVDCGIPE-SIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGS 408
Query: 197 W 197
W
Sbjct: 409 W 409
>gi|41393602 complement component 1, s subcomponent precursor [Homo
sapiens]
Length = 688
Score = 74.3 bits (181), Expect = 4e-13
Identities = 67/239 (28%), Positives = 100/239 (41%), Gaps = 37/239 (15%)
Query: 473 SDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKE 532
+D + PW V GALI++ WVLTAAH + +++ + S+ K
Sbjct: 444 ADIKNFPWQVFF---DNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKS 500
Query: 533 FLI--EKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCT----- 585
++ E I PG+ + + +G F +DIAL++L VKM PICLP T
Sbjct: 501 KMLTPEHVFIHPGWKLL-EVPEGRTNF-DNDIALVRLKDPVKMGPTVSPICLPGTSSDYN 558
Query: 586 -MEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQ 644
M+ +L L G T + L +P C EV
Sbjct: 559 LMDGDLGLISGWGRTEKRDRAVRLKAARLPV-----------------APLRKCKEV--- 598
Query: 645 EKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLE---RRFRFFQVGLVSWG 700
K P V T +C+G ++ CKG+SGGA ++ + +F+ GLVSWG
Sbjct: 599 -KVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWG 656
Score = 39.3 bits (90), Expect = 0.014
Identities = 27/81 (33%), Positives = 36/81 (44%), Gaps = 13/81 (16%)
Query: 64 CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENG-IYTPRLGSYPVGGNVSFECEDGFI 122
C+S+G+W S SK C+PV C P S ENG + P S G + + CE+ +
Sbjct: 341 CQSNGKW-------SNSKLKCQPVDCGIPESIENGKVEDPE--STLFGSVIRYTCEEPYY 391
Query: 123 LR---GSPVRQCRPNGMWDGE 140
G C NG W E
Sbjct: 392 YMENGGGGEYHCAGNGSWVNE 412
Score = 38.5 bits (88), Expect = 0.023
Identities = 33/121 (27%), Positives = 41/121 (33%), Gaps = 11/121 (9%)
Query: 86 PVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGF-ILRG-----SPVRQCRPNGMWDG 139
P+ CP + N ++ P Y V C DGF ++ G S C+ NG W
Sbjct: 291 PMPCPKEDT-PNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSN 349
Query: 140 ETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT---GSSERECQGNGV 196
C P I G V G +RY C G E C GNG
Sbjct: 350 SKLKCQPVDCGIPE-SIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGS 408
Query: 197 W 197
W
Sbjct: 409 W 409
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 73.9 bits (180), Expect = 5e-13
Identities = 64/230 (27%), Positives = 105/230 (45%), Gaps = 35/230 (15%)
Query: 479 PWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVG----DPKSQWGKEFL 534
PW V+I + C G+L+S+QWVL+AAHCF + + V +G D S+ K
Sbjct: 57 PWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVST 116
Query: 535 IEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRR 594
++ + P + + +QG DIALL+L++ + S + RPICLP AN +
Sbjct: 117 LKDIIPHPSY--LQEGSQG-------DIALLQLSRPITFSRYIRPICLPA---ANASF-- 162
Query: 595 PQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGV---EWTSCAEVVSQEKTMFPN 651
P G C + A V+L K L++ + E +C + +
Sbjct: 163 PNGLHC------TVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAK------ 210
Query: 652 LTDVREVVTDQFLCSGTQE-DESPCKGESGGAVFLERRFRFFQVGLVSWG 700
+ V + +C+G E + C+G+SGG + ++ G+VSWG
Sbjct: 211 -PEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWG 259
>gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens]
Length = 410
Score = 73.6 bits (179), Expect = 6e-13
Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 33/230 (14%)
Query: 476 ERTPWHVTIKPKSQETCRGALISDQWVLTAAHC-FRD-GNDHSLWRV-NVGDPKSQWGKE 532
++ PW V+++ + C G+LI +WVLTAAHC FR G + W + +G W
Sbjct: 172 KKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLAGIGRWDQAWKH- 230
Query: 533 FLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLAL 592
+E + FD FA DIAL LA V S+H +P CLP
Sbjct: 231 --LEDIIFPSNFD-FATLT--------SDIALALLAYSVNYSSHIQPACLP-----EKLF 274
Query: 593 RRPQGSTC-RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPN 651
G+ C ++ S P V L ++LNI + C E++ +
Sbjct: 275 EVEAGTECWVTGWGQVSESVSGPMPLV-LQETELNI-----MRHEKCCEMLKNKN----- 323
Query: 652 LTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGL 701
++VT +C + + C+G+SGG + E + QVG+VSWG+
Sbjct: 324 -ISKSKMVTRGTVCGYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGI 372
>gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo
sapiens]
Length = 410
Score = 73.6 bits (179), Expect = 6e-13
Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 33/230 (14%)
Query: 476 ERTPWHVTIKPKSQETCRGALISDQWVLTAAHC-FRD-GNDHSLWRV-NVGDPKSQWGKE 532
++ PW V+++ + C G+LI +WVLTAAHC FR G + W + +G W
Sbjct: 172 KKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLAGIGRWDQAWKH- 230
Query: 533 FLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLAL 592
+E + FD FA DIAL LA V S+H +P CLP
Sbjct: 231 --LEDIIFPSNFD-FATLT--------SDIALALLAYSVNYSSHIQPACLP-----EKLF 274
Query: 593 RRPQGSTC-RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPN 651
G+ C ++ S P V L ++LNI + C E++ +
Sbjct: 275 EVEAGTECWVTGWGQVSESVSGPMPLV-LQETELNI-----MRHEKCCEMLKNKN----- 323
Query: 652 LTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGL 701
++VT +C + + C+G+SGG + E + QVG+VSWG+
Sbjct: 324 -ISKSKMVTRGTVCGYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGI 372
>gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo
sapiens]
Length = 410
Score = 73.6 bits (179), Expect = 6e-13
Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 33/230 (14%)
Query: 476 ERTPWHVTIKPKSQETCRGALISDQWVLTAAHC-FRD-GNDHSLWRV-NVGDPKSQWGKE 532
++ PW V+++ + C G+LI +WVLTAAHC FR G + W + +G W
Sbjct: 172 KKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLAGIGRWDQAWKH- 230
Query: 533 FLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLAL 592
+E + FD FA DIAL LA V S+H +P CLP
Sbjct: 231 --LEDIIFPSNFD-FATLT--------SDIALALLAYSVNYSSHIQPACLP-----EKLF 274
Query: 593 RRPQGSTC-RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPN 651
G+ C ++ S P V L ++LNI + C E++ +
Sbjct: 275 EVEAGTECWVTGWGQVSESVSGPMPLV-LQETELNI-----MRHEKCCEMLKNKN----- 323
Query: 652 LTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGL 701
++VT +C + + C+G+SGG + E + QVG+VSWG+
Sbjct: 324 -ISKSKMVTRGTVCGYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGI 372
>gi|148806900 epidermis-specific serine protease-like protein [Homo
sapiens]
Length = 328
Score = 73.6 bits (179), Expect = 6e-13
Identities = 69/253 (27%), Positives = 116/253 (45%), Gaps = 55/253 (21%)
Query: 465 VGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFR---DGNDHSLW--R 519
VG A A R PW V++ C G+L+S++ +LTAAHC + +++W
Sbjct: 29 VGGQDAAAG---RWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFSYTVWLGS 85
Query: 520 VNVGDPKSQWGKEFLIEKAVISPGF-DVFAKKNQGILEFYGDDIALLKLAQKVKMSTHAR 578
+ VGD + + ++ + K VI P + D A D+ALLKL+ +V ++
Sbjct: 86 ITVGDSRKR--VKYYVSKIVIHPKYQDTTA------------DVALLKLSSQVTFTSAIL 131
Query: 579 PICLPCTMEANLAL---------RRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINL 629
PICLP ++ LA+ + + S+ RD+ + L + VP
Sbjct: 132 PICLP-SVTKQLAIPPFCWVTGWGKVKESSDRDY-HSALQEAEVPI-------------- 175
Query: 630 KMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSG-TQEDESPCKGESGGAVFLERR 688
++ +C ++ + P L V+ + +C+G TQ + CKG+SGG +
Sbjct: 176 ---IDRQACEQLYNPIGIFLPAL---EPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHID 229
Query: 689 FRFFQVGLVSWGL 701
+ Q G+VSWGL
Sbjct: 230 GVWIQTGVVSWGL 242
>gi|62912468 complement component 4 binding protein, beta chain
isoform 1 precursor [Homo sapiens]
Length = 252
Score = 73.2 bits (178), Expect = 8e-13
Identities = 64/236 (27%), Positives = 92/236 (38%), Gaps = 18/236 (7%)
Query: 9 CLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLL-TYSCPQGLYPSPASRL-CKS 66
CL+ + A A CP+ + F G +L TY C +G + L C +
Sbjct: 8 CLMVAWRVSASDAEHCPELPPVDNSIFVAKE--VEGQILGTYVCIKGYHLVGKKTLFCNA 65
Query: 67 SGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGS 126
S +W + C+ CP PV NG ++ G V ++F C D +IL+GS
Sbjct: 66 SKEWDN-------TTTECRLGHCPDPV-LVNGEFSSS-GPVNVSDKITFMCNDHYILKGS 116
Query: 127 PVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS 186
QC + W +C + C PG + G F G + Y C L G
Sbjct: 117 NRSQCLEDHTWAPPFPICKSR--DCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGV 174
Query: 187 SERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHML--GATNPTQKTKES 240
E++C +G WS P+C+ PE L S L N Q+ KES
Sbjct: 175 QEQQCV-DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKES 229
>gi|62912464 complement component 4 binding protein, beta chain
isoform 1 precursor [Homo sapiens]
Length = 252
Score = 73.2 bits (178), Expect = 8e-13
Identities = 64/236 (27%), Positives = 92/236 (38%), Gaps = 18/236 (7%)
Query: 9 CLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLL-TYSCPQGLYPSPASRL-CKS 66
CL+ + A A CP+ + F G +L TY C +G + L C +
Sbjct: 8 CLMVAWRVSASDAEHCPELPPVDNSIFVAKE--VEGQILGTYVCIKGYHLVGKKTLFCNA 65
Query: 67 SGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGS 126
S +W + C+ CP PV NG ++ G V ++F C D +IL+GS
Sbjct: 66 SKEWDN-------TTTECRLGHCPDPV-LVNGEFSSS-GPVNVSDKITFMCNDHYILKGS 116
Query: 127 PVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS 186
QC + W +C + C PG + G F G + Y C L G
Sbjct: 117 NRSQCLEDHTWAPPFPICKSR--DCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGV 174
Query: 187 SERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHML--GATNPTQKTKES 240
E++C +G WS P+C+ PE L S L N Q+ KES
Sbjct: 175 QEQQCV-DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKES 229
>gi|4502505 complement component 4 binding protein, beta chain
isoform 1 precursor [Homo sapiens]
Length = 252
Score = 73.2 bits (178), Expect = 8e-13
Identities = 64/236 (27%), Positives = 92/236 (38%), Gaps = 18/236 (7%)
Query: 9 CLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLL-TYSCPQGLYPSPASRL-CKS 66
CL+ + A A CP+ + F G +L TY C +G + L C +
Sbjct: 8 CLMVAWRVSASDAEHCPELPPVDNSIFVAKE--VEGQILGTYVCIKGYHLVGKKTLFCNA 65
Query: 67 SGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGS 126
S +W + C+ CP PV NG ++ G V ++F C D +IL+GS
Sbjct: 66 SKEWDN-------TTTECRLGHCPDPV-LVNGEFSSS-GPVNVSDKITFMCNDHYILKGS 116
Query: 127 PVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS 186
QC + W +C + C PG + G F G + Y C L G
Sbjct: 117 NRSQCLEDHTWAPPFPICKSR--DCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGV 174
Query: 187 SERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHML--GATNPTQKTKES 240
E++C +G WS P+C+ PE L S L N Q+ KES
Sbjct: 175 QEQQCV-DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKES 229
>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
Length = 416
Score = 73.2 bits (178), Expect = 8e-13
Identities = 78/282 (27%), Positives = 126/282 (44%), Gaps = 81/282 (28%)
Query: 452 MLDVSK-----LTDTICG--------VGNMSAN--ASDQERTPWHVTIKPKSQETCRGAL 496
++++SK LT+ CG GN N +S + PW +++ K + C +L
Sbjct: 155 LMEISKAASEMLTNNCCGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASL 214
Query: 497 ISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGIL- 555
IS +W+L+AAHCF N+ W VN G ++ K ++ +K Q I+
Sbjct: 215 ISSRWLLSAAHCFAKKNNSKDWTVNFG---------IVVNKPYMT-------RKVQNIIF 258
Query: 556 -EFYG-----DDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLN 609
E Y DDIAL++LA++V + + R ICLP EA + L +++N ++
Sbjct: 259 HENYSSPGLHDDIALVQLAEEVSFTEYIRKICLP---EAKMKL--------SENDNVVVT 307
Query: 610 KQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVR---------EVVT 660
+ +NGS V+ QE F + D + VT
Sbjct: 308 GWGT----LYMNGS---------------FPVILQED--FLKIIDNKICNASYAYSGFVT 346
Query: 661 DQFLCSGTQEDES-PCKGESGGAV-FLERRFRFFQVGLVSWG 700
D LC+G E+ C+ +SGG + + + R + VG+VSWG
Sbjct: 347 DTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWG 388
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,016,302
Number of Sequences: 37866
Number of extensions: 1509028
Number of successful extensions: 4490
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 218
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 3194
Number of HSP's gapped (non-prelim): 811
length of query: 752
length of database: 18,247,518
effective HSP length: 110
effective length of query: 642
effective length of database: 14,082,258
effective search space: 9040809636
effective search space used: 9040809636
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.