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Search of human proteins with 95147335
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo
sapiens]
(2701 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo s... 5413 0.0
gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isofor... 3710 0.0
gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isofor... 3704 0.0
gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo ... 3421 0.0
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 167 1e-40
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 167 1e-40
gi|126032338 ryanodine receptor 3 [Homo sapiens] 167 1e-40
gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens] 164 1e-39
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 37 0.34
gi|134152674 rabaptin, RAB GTPase binding effector protein 1 iso... 34 1.7
gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isof... 34 1.7
gi|148233596 LPS-responsive vesicle trafficking, beach and ancho... 33 3.8
gi|116812628 coiled-coil domain containing 67 [Homo sapiens] 33 3.8
gi|62988331 hypothetical protein LOC55780 [Homo sapiens] 33 3.8
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 33 5.0
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 33 5.0
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 33 5.0
gi|4507691 transformation/transcription domain-associated protei... 33 5.0
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 33 5.0
gi|5454158 valyl-tRNA synthetase [Homo sapiens] 33 5.0
gi|194306660 coiled-coil domain containing 77 isoform b [Homo sa... 32 6.5
gi|194306658 coiled-coil domain containing 77 isoform b [Homo sa... 32 6.5
gi|14150165 coiled-coil domain containing 77 isoform a [Homo sap... 32 6.5
gi|194306535 coiled-coil domain containing 77 isoform b [Homo sa... 32 6.5
gi|55741447 pleckstrin homology domain containing, family H (wit... 32 6.5
gi|226246554 hypothetical protein LOC643677 [Homo sapiens] 32 8.5
gi|239750569 PREDICTED: hypothetical protein LOC643677 [Homo sap... 32 8.5
gi|239744870 PREDICTED: hypothetical protein LOC643677 [Homo sap... 32 8.5
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 32 8.5
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 32 8.5
>gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo
sapiens]
Length = 2701
Score = 5413 bits (14042), Expect = 0.0
Identities = 2701/2701 (100%), Positives = 2701/2701 (100%)
Query: 1 MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKV 60
MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKV
Sbjct: 1 MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKV 60
Query: 61 CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNV 120
CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNV
Sbjct: 61 CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNV 120
Query: 121 IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD 180
IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD
Sbjct: 121 IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD 180
Query: 181 KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVV 240
KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVV
Sbjct: 181 KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVV 240
Query: 241 RLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN 300
RLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN
Sbjct: 241 RLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN 300
Query: 301 SLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG 360
SLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG
Sbjct: 301 SLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG 360
Query: 361 NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTC 420
NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTC
Sbjct: 361 NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTC 420
Query: 421 QTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLI 480
QTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLI
Sbjct: 421 QTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLI 480
Query: 481 FFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED 540
FFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED
Sbjct: 481 FFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED 540
Query: 541 LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLH 600
LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLH
Sbjct: 541 LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLH 600
Query: 601 NNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPG 660
NNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPG
Sbjct: 601 NNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPG 660
Query: 661 NADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGT 720
NADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGT
Sbjct: 661 NADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGT 720
Query: 721 KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCR 780
KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCR
Sbjct: 721 KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCR 780
Query: 781 LMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEE 840
LMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEE
Sbjct: 781 LMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEE 840
Query: 841 YLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM 900
YLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM
Sbjct: 841 YLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM 900
Query: 901 SSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTE 960
SSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTE
Sbjct: 901 SSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTE 960
Query: 961 HEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLP 1020
HEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLP
Sbjct: 961 HEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLP 1020
Query: 1021 SAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLL 1080
SAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLL
Sbjct: 1021 SAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLL 1080
Query: 1081 FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGE 1140
FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGE
Sbjct: 1081 FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGE 1140
Query: 1141 IGESQVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCR 1200
IGESQVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCR
Sbjct: 1141 IGESQVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCR 1200
Query: 1201 NQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHL 1260
NQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHL
Sbjct: 1201 NQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHL 1260
Query: 1261 NLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD 1320
NLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD
Sbjct: 1261 NLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD 1320
Query: 1321 GKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVE 1380
GKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVE
Sbjct: 1321 GKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVE 1380
Query: 1381 LLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKE 1440
LLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKE
Sbjct: 1381 LLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKE 1440
Query: 1441 IYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNST 1500
IYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNST
Sbjct: 1441 IYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNST 1500
Query: 1501 SLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVN 1560
SLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVN
Sbjct: 1501 SLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVN 1560
Query: 1561 TLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPM 1620
TLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPM
Sbjct: 1561 TLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPM 1620
Query: 1621 MQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLRE 1680
MQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLRE
Sbjct: 1621 MQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLRE 1680
Query: 1681 MLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGI 1740
MLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGI
Sbjct: 1681 MLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGI 1740
Query: 1741 SMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQ 1800
SMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQ
Sbjct: 1741 SMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQ 1800
Query: 1801 KKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLK 1860
KKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLK
Sbjct: 1801 KKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLK 1860
Query: 1861 EGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQP 1920
EGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQP
Sbjct: 1861 EGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQP 1920
Query: 1921 ILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEK 1980
ILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEK
Sbjct: 1921 ILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEK 1980
Query: 1981 NVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQL 2040
NVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQL
Sbjct: 1981 NVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQL 2040
Query: 2041 KNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVS 2100
KNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVS
Sbjct: 2041 KNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVS 2100
Query: 2101 PKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQ 2160
PKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQ
Sbjct: 2101 PKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQ 2160
Query: 2161 IVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALF 2220
IVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALF
Sbjct: 2161 IVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALF 2220
Query: 2221 WFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFF 2280
WFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFF
Sbjct: 2221 WFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFF 2280
Query: 2281 FSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAV 2340
FSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAV
Sbjct: 2281 FSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAV 2340
Query: 2341 ILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAV 2400
ILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAV
Sbjct: 2341 ILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAV 2400
Query: 2401 LALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPT 2460
LALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPT
Sbjct: 2401 LALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPT 2460
Query: 2461 IPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVY 2520
IPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVY
Sbjct: 2461 IPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVY 2520
Query: 2521 DLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE 2580
DLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE
Sbjct: 2521 DLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE 2580
Query: 2581 EHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGD 2640
EHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGD
Sbjct: 2581 EHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGD 2640
Query: 2641 SEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPP 2700
SEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPP
Sbjct: 2641 SEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPP 2700
Query: 2701 H 2701
H
Sbjct: 2701 H 2701
>gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isoform 1
[Homo sapiens]
Length = 2710
Score = 3710 bits (9620), Expect = 0.0
Identities = 1901/2729 (69%), Positives = 2225/2729 (81%), Gaps = 60/2729 (2%)
Query: 1 MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKV 60
M++KMSSFL+IGDI SLYAEGS NGFISTLGLVDDRCVV PE GDL NPPKKFRDCLFK+
Sbjct: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
Query: 61 CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNV 120
CPMNRYSAQKQ+WKA + + T+A LL KL HAA+LE+KQNE+EN+KLLG +++Y NV
Sbjct: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
Query: 121 IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD 180
IQLLH+KSNKYLTVNKRLPALLEKNAMRV+LD AGNEGSWFYI PF+KLRS GD++V+GD
Sbjct: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
Query: 181 KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVV 240
KVVL PVNAGQPLHAS+ +L+DNPGC EVN+VNCNTSWKI LFMK+S ++D+LKGGDVV
Sbjct: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
Query: 241 RLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN 300
RLFHAEQEKFLTCDE+ KKQH+FLRTT RQSATSATSSKALWE+EVV HDPCRGGAG WN
Sbjct: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
Query: 301 SLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKK-RQAGEKIMYTLVSVPH 359
SLFRFKHLATG+YLAAE++PD+ + E + D S+ + R A EK++Y+LVSVP
Sbjct: 301 SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE 360
Query: 360 GNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGT 419
GNDI+S+FELD TTL+ D LVPRNSYVRLRHLCTNTWV ST+IPID +EE+PVMLKIGT
Sbjct: 361 GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT 420
Query: 420 CQTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDL 479
KEDKEAFAIV V +EVRDLDFANDA+KVL + KLE GTITQNERR VTKLLEDL
Sbjct: 421 SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL 480
Query: 480 IFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLE 539
++FV N+GQ+VL+VV +KPNRERQKLMREQNIL Q+F +L+APF + G+G MLRLE
Sbjct: 481 VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTD-CGDGPMLRLE 539
Query: 540 DLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALL 599
+LGDQR+AP++++ RLCYRVLRHSQQDYRKNQEYIAK F MQ QIGYD+LAEDTITALL
Sbjct: 540 ELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALL 599
Query: 600 HNNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSP 659
HNNRKLLEKHITA EI+TFVSL+R+NREPRFLDYLSDLCVS +IPVTQELICK +L+P
Sbjct: 600 HNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNP 659
Query: 660 GNADILIQTKVVSMQADNPMESSI----LSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQE 715
NADILI+TK+V + + SS L D+EEVWL+W DSNKE K++R LAQ+
Sbjct: 660 TNADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQD 719
Query: 716 AKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLR 775
AKEG K D +VL+YYRYQLNLFARMCLDRQYLAIN+IS QL VDLILRC+SDE+LP+DLR
Sbjct: 720 AKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLR 779
Query: 776 ASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTM 835
ASFCRLMLHMHVDRDPQE V PV+YARLW+EIP++I I +YDS + +S++++K +FA TM
Sbjct: 780 ASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS-SGASKDEIKERFAQTM 838
Query: 836 EFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDI 895
EFVEEYL++VV Q FPF DKEKNKLTFEVV+LARNLIYFGFY+FS+LLRLT+ LLAILD
Sbjct: 839 EFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDC 898
Query: 896 VQAPMSSYFERLSKFQDG-GNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSK 954
V +++K ++ G+NVMR+IHGVGE+MTQ+VL G PM+ P + K
Sbjct: 899 VHVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNV-K 957
Query: 955 QGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGS 1014
Q P E ED+ VMDTKLKIIEILQFIL+VRLDYRIS +L I+K+EF E N ++SG+
Sbjct: 958 QAEP-EKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGN 1016
Query: 1015 PDTLLPSAI--VPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPL 1072
PS + D + I QAE +F GRKE P+ LDD GGRTFLRVL+HL MHDYPPL
Sbjct: 1017 SSQEGPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPL 1076
Query: 1073 LSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEK 1132
+SGALQLLF+HFSQR EVLQAFKQVQLLV++QDVDNYKQIK DLDQLR VEKSELWV K
Sbjct: 1077 VSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYK 1136
Query: 1133 SSNYE---NGEIGESQVKGGEEPIEESNILSPVQDGTKKPQI-DSNKSNNYRIVKEILIR 1188
+ +G GE++ K EE G KPQ +S S NYR+VKEILIR
Sbjct: 1137 GQGPDETMDGASGENEHKKTEE-------------GNNKPQKHESTSSYNYRVVKEILIR 1183
Query: 1189 LSKLCVQN----KKCRNQHQRLLKNMGAHSVVLDLLQIPYEK-NDEKMNEVMNLAHTFLQ 1243
LSKLCVQ +K R Q QRLL+NMGAH+VVL+LLQIPYEK D KM E+M LAH FLQ
Sbjct: 1184 LSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQ 1243
Query: 1244 NFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETH 1303
NFC GN QNQ LLHKH+NLFL PG+LEA TM+HIFMNN+ LC+EI+ERVVQHFVHCIETH
Sbjct: 1244 NFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETH 1303
Query: 1304 GRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSER 1363
GR+V+Y++FLQTIVKA+GK++KKCQDMVM EL+N GEDVL+FYNDRASF L+ MM SER
Sbjct: 1304 GRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSER 1363
Query: 1364 DRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAY 1423
DR DE+ PL YHI LVELLA CTEGKNVYTEIKCNSLLPLDDIVRVVTH+DCIPEVKIAY
Sbjct: 1364 DRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAY 1423
Query: 1424 VNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESI 1483
+NF+NHCYVDTEVEMKEIYTSNH+WKLFENFLVD+ R CN T+DRKHAD LEK VTE +
Sbjct: 1424 INFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIV 1483
Query: 1484 MNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEV 1543
M+IV+ FF+SPFSD ST+LQT QPVF+QLLQ FR+Y+C W P+QKASVESCIR L++V
Sbjct: 1484 MSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDV 1543
Query: 1544 AKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNII 1603
AK+R IAIPVDLDSQVN LF+KSHS +VQ+ AM WRLSAR+ R ++++ + DYRNII
Sbjct: 1544 AKSRAIAIPVDLDSQVNNLFLKSHS-IVQKTAMNWRLSARNAAR-RDSVLAASRDYRNII 1601
Query: 1604 EKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTK 1661
E+LQD+V++LE + P++QAE SVLVDVL+ PELLFPE +DAR +C G F+ KLI HTK
Sbjct: 1602 ERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTK 1661
Query: 1662 KLMEK-EEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIG--------V 1712
+L+E+ EEKLCIK+LQTLREM+ K + E+G LR++L+NRY+ G
Sbjct: 1662 QLLEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFG 1721
Query: 1713 NGHLSGAYSKTAQVGGSFSGQDSDKMG-ISMSDIQCLLDKEGASELVIDVIVNTKNDRIF 1771
NG LS GG SG S G +S++++QC LDKEGAS LVID+I+N +DR+F
Sbjct: 1722 NGPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVF 1781
Query: 1772 SEGIFLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTID 1831
E I L IALLEGGNT Q+SF+ +L E KKSEKFFKV YDRMK AQ+EI++TVTVNT D
Sbjct: 1782 HESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSD 1841
Query: 1832 LGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDI 1891
LGNKK+DD+ + + R + ++ T + E ++ QL EAS+AT KA+ +RRE DP+ D
Sbjct: 1842 LGNKKKDDEVD-RDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPD-DH 1899
Query: 1892 MCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNL 1951
G T +K+ +++ MS I IMQPILRFLQLLCENHNR+LQNFLR QNNKTNYNL
Sbjct: 1900 YQPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNL 1959
Query: 1952 VCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHE 2011
VCETLQFLDCICGSTTGGLGLLGLYINEKNVAL+NQ LESLTEYCQGPCHENQ CIATHE
Sbjct: 1960 VCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHE 2019
Query: 2012 SNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPR 2071
SNGIDII ALILNDINPLGK RMDLVL+LKNNASKLLLAIMESRHDSENAERIL+NMRP+
Sbjct: 2020 SNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPK 2079
Query: 2072 ELVDVMKNAYNQGLECDHGDDEGGDDG-VSPKDVGHNIYILAHQLARHNKLLQQMLKPGS 2130
ELV+V+K AY QG E + D E G+DG SP++VGHNIYILAHQLARHNK LQ MLKPG
Sbjct: 2080 ELVEVIKKAYMQG-EVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGG 2138
Query: 2131 DPDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQG 2190
D GDEAL++YA HTAQIEIVR DRTMEQIVFPVP+ICE+LT+ESK R++ TTERDEQG
Sbjct: 2139 QVD-GDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQG 2197
Query: 2191 SKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPF 2250
SK+NDFF ++EDL+NEM WQKK+R P L+W +R++S W SISFNLAV +NL VA FYPF
Sbjct: 2198 SKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPF 2257
Query: 2251 -GDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLI 2309
G G GTL P +S LLW A+ I +++ KP GIR + S +LR I+++GL PTL
Sbjct: 2258 KGVRG--GTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLF 2315
Query: 2310 LLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSF 2369
LLGA N+CNKI+FL+SFVGN GTFTRGYRA++LD+ FLYH+ Y+++C +GLFVHEFFYS
Sbjct: 2316 LLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSL 2375
Query: 2370 LLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLK 2429
LLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSI+G+LF KDDF +EVDRL
Sbjct: 2376 LLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLP 2435
Query: 2430 NRT--PVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTAD-EEYEDGIERTCDTLLMCI 2486
N T P TG + + + ENCS P EE E E TC+TLLMCI
Sbjct: 2436 NETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELVPAEETEQDKEHTCETLLMCI 2495
Query: 2487 VTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFAD 2546
VTVL+ GLR+GGGVGDVLR+PSK+EPLFAARV+YDLLF+F+VIIIVLNLIFGVIIDTFAD
Sbjct: 2496 VTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFAD 2555
Query: 2547 LRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTE 2606
LRSEKQKKEEILKTTCFICGLERDKFDNKTV+FEEHIK EHNMWHYL FIVLVKVKD TE
Sbjct: 2556 LRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTE 2615
Query: 2607 YTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQ 2666
YTGPESYVA+MI E+NLDWFPRMRAMSLVS++ + EQNE+R+LQEKLESTM LV LSGQ
Sbjct: 2616 YTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQ 2675
Query: 2667 LAELKEQMTEQRKNKQRLGFLGSNTPHVN 2695
L+ELK+QMTEQRK KQR+G LG + PH+N
Sbjct: 2676 LSELKDQMTEQRKQKQRIGLLG-HPPHMN 2703
>gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isoform 2
[Homo sapiens]
Length = 2695
Score = 3704 bits (9606), Expect = 0.0
Identities = 1900/2728 (69%), Positives = 2221/2728 (81%), Gaps = 73/2728 (2%)
Query: 1 MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKV 60
M++KMSSFL+IGDI SLYAEGS NGFISTLGLVDDRCVV PE GDL NPPKKFRDCLFK+
Sbjct: 1 MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL 60
Query: 61 CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNV 120
CPMNRYSAQKQ+WKA + + T+A LL KL HAA+LE+KQNE+EN+KLLG +++Y NV
Sbjct: 61 CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV 120
Query: 121 IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD 180
IQLLH+KSNKYLTVNKRLPALLEKNAMRV+LD AGNEGSWFYI PF+KLRS GD++V+GD
Sbjct: 121 IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD 180
Query: 181 KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVV 240
KVVL PVNAGQPLHAS+ +L+DNPGC EVN+VNCNTSWKI LFMK+S ++D+LKGGDVV
Sbjct: 181 KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV 240
Query: 241 RLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN 300
RLFHAEQEKFLTCDE+ KKQH+FLRTT RQSATSATSSKALWE+EVV HDPCRGGAG WN
Sbjct: 241 RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN 300
Query: 301 SLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG 360
SLFRFKHLATG+YLAAE++PD +DA + R A EK++Y+LVSVP G
Sbjct: 301 SLFRFKHLATGHYLAAEVDPD-QDASRS-------------RLRNAQEKMVYSLVSVPEG 346
Query: 361 NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTC 420
NDI+S+FELD TTL+ D LVPRNSYVRLRHLCTNTWV ST+IPID +EE+PVMLKIGT
Sbjct: 347 NDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTS 406
Query: 421 QTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLI 480
KEDKEAFAIV V +EVRDLDFANDA+KVL + KLE GTITQNERR VTKLLEDL+
Sbjct: 407 PVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLV 466
Query: 481 FFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED 540
+FV N+GQ+VL+VV +KPNRERQKLMREQNIL Q+F +L+APF + G+G MLRLE+
Sbjct: 467 YFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTD-CGDGPMLRLEE 525
Query: 541 LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLH 600
LGDQR+AP++++ RLCYRVLRHSQQDYRKNQEYIAK F MQ QIGYD+LAEDTITALLH
Sbjct: 526 LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH 585
Query: 601 NNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPG 660
NNRKLLEKHITA EI+TFVSL+R+NREPRFLDYLSDLCVS +IPVTQELICK +L+P
Sbjct: 586 NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT 645
Query: 661 NADILIQTKVVSMQADNPMESSI----LSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEA 716
NADILI+TK+V + + SS L D+EEVWL+W DSNKE K++R LAQ+A
Sbjct: 646 NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA 705
Query: 717 KEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRA 776
KEG K D +VL+YYRYQLNLFARMCLDRQYLAIN+IS QL VDLILRC+SDE+LP+DLRA
Sbjct: 706 KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA 765
Query: 777 SFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTME 836
SFCRLMLHMHVDRDPQE V PV+YARLW+EIP++I I +YDS + +S++++K +FA TME
Sbjct: 766 SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDS-SGASKDEIKERFAQTME 824
Query: 837 FVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIV 896
FVEEYL++VV Q FPF DKEKNKLTFEVV+LARNLIYFGFY+FS+LLRLT+ LLAILD V
Sbjct: 825 FVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCV 884
Query: 897 QAPMSSYFERLSKFQDG-GNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQ 955
+++K ++ G+NVMR+IHGVGE+MTQ+VL G PM+ P + KQ
Sbjct: 885 HVTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNV-KQ 943
Query: 956 GSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSP 1015
P E ED+ VMDTKLKIIEILQFIL+VRLDYRIS +L I+K+EF E N ++SG+
Sbjct: 944 AEP-EKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNS 1002
Query: 1016 DTLLPSAI--VPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLL 1073
PS + D + I QAE +F GRKE P+ LDD GGRTFLRVL+HL MHDYPPL+
Sbjct: 1003 SQEGPSNVPGALDFEHIEEQAEGIFGGRKENTPLDLDDHGGRTFLRVLLHLTMHDYPPLV 1062
Query: 1074 SGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKS 1133
SGALQLLF+HFSQR EVLQAFKQVQLLV++QDVDNYKQIK DLDQLR VEKSELWV K
Sbjct: 1063 SGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKG 1122
Query: 1134 SNYE---NGEIGESQVKGGEEPIEESNILSPVQDGTKKPQI-DSNKSNNYRIVKEILIRL 1189
+ +G GE++ K EE G KPQ +S S NYR+VKEILIRL
Sbjct: 1123 QGPDETMDGASGENEHKKTEE-------------GNNKPQKHESTSSYNYRVVKEILIRL 1169
Query: 1190 SKLCVQN----KKCRNQHQRLLKNMGAHSVVLDLLQIPYEK-NDEKMNEVMNLAHTFLQN 1244
SKLCVQ +K R Q QRLL+NMGAH+VVL+LLQIPYEK D KM E+M LAH FLQN
Sbjct: 1170 SKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQN 1229
Query: 1245 FCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHG 1304
FC GN QNQ LLHKH+NLFL PG+LEA TM+HIFMNN+ LC+EI+ERVVQHFVHCIETHG
Sbjct: 1230 FCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHG 1289
Query: 1305 RHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERD 1364
R+V+Y++FLQTIVKA+GK++KKCQDMVM EL+N GEDVL+FYNDRASF L+ MM SERD
Sbjct: 1290 RNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERD 1349
Query: 1365 RGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYV 1424
R DE+ PL YHI LVELLA CTEGKNVYTEIKCNSLLPLDDIVRVVTH+DCIPEVKIAY+
Sbjct: 1350 RMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYI 1409
Query: 1425 NFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIM 1484
NF+NHCYVDTEVEMKEIYTSNH+WKLFENFLVD+ R CN T+DRKHAD LEK VTE +M
Sbjct: 1410 NFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVM 1469
Query: 1485 NIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVA 1544
+IV+ FF+SPFSD ST+LQT QPVF+QLLQ FR+Y+C W P+QKASVESCIR L++VA
Sbjct: 1470 SIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVA 1529
Query: 1545 KNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIE 1604
K+R IAIPVDLDSQVN LF+KSHS +VQ+ AM WRLSAR+ R ++++ + DYRNIIE
Sbjct: 1530 KSRAIAIPVDLDSQVNNLFLKSHS-IVQKTAMNWRLSARNAAR-RDSVLAASRDYRNIIE 1587
Query: 1605 KLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKK 1662
+LQD+V++LE + P++QAE SVLVDVL+ PELLFPE +DAR +C G F+ KLI HTK+
Sbjct: 1588 RLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQ 1647
Query: 1663 LMEK-EEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIG--------VN 1713
L+E+ EEKLCIK+LQTLREM+ K + E+G LR++L+NRY+ G N
Sbjct: 1648 LLEENEEKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGN 1707
Query: 1714 GHLSGAYSKTAQVGGSFSGQDSDKMG-ISMSDIQCLLDKEGASELVIDVIVNTKNDRIFS 1772
G LS GG SG S G +S++++QC LDKEGAS LVID+I+N +DR+F
Sbjct: 1708 GPLSAGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFH 1767
Query: 1773 EGIFLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDL 1832
E I L IALLEGGNT Q+SF+ +L E KKSEKFFKV YDRMK AQ+EI++TVTVNT DL
Sbjct: 1768 ESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDL 1827
Query: 1833 GNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIM 1892
GNKK+DD+ + + R + ++ T + E ++ QL EAS+AT KA+ +RRE DP+ D
Sbjct: 1828 GNKKKDDEVD-RDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPD-DHY 1885
Query: 1893 CTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLV 1952
G T +K+ +++ MS I IMQPILRFLQLLCENHNR+LQNFLR QNNKTNYNLV
Sbjct: 1886 QPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLV 1945
Query: 1953 CETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHES 2012
CETLQFLDCICGSTTGGLGLLGLYINEKNVAL+NQ LESLTEYCQGPCHENQ CIATHES
Sbjct: 1946 CETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHES 2005
Query: 2013 NGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRE 2072
NGIDII ALILNDINPLGK RMDLVL+LKNNASKLLLAIMESRHDSENAERIL+NMRP+E
Sbjct: 2006 NGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKE 2065
Query: 2073 LVDVMKNAYNQGLECDHGDDEGGDDG-VSPKDVGHNIYILAHQLARHNKLLQQMLKPGSD 2131
LV+V+K AY QG E + D E G+DG SP++VGHNIYILAHQLARHNK LQ MLKPG
Sbjct: 2066 LVEVIKKAYMQG-EVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQ 2124
Query: 2132 PDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGS 2191
D GDEAL++YA HTAQIEIVR DRTMEQIVFPVP+ICE+LT+ESK R++ TTERDEQGS
Sbjct: 2125 VD-GDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGS 2183
Query: 2192 KVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPF- 2250
K+NDFF ++EDL+NEM WQKK+R P L+W +R++S W SISFNLAV +NL VA FYPF
Sbjct: 2184 KINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFK 2243
Query: 2251 GDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLIL 2310
G G GTL P +S LLW A+ I +++ KP GIR + S +LR I+++GL PTL L
Sbjct: 2244 GVRG--GTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFL 2301
Query: 2311 LGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFL 2370
LGA N+CNKI+FL+SFVGN GTFTRGYRA++LD+ FLYH+ Y+++C +GLFVHEFFYS L
Sbjct: 2302 LGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLL 2361
Query: 2371 LFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKN 2430
LFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSI+G+LF KDDF +EVDRL N
Sbjct: 2362 LFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPN 2421
Query: 2431 RT--PVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTAD-EEYEDGIERTCDTLLMCIV 2487
T P TG + + + ENCS P EE E E TC+TLLMCIV
Sbjct: 2422 ETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELVPAEETEQDKEHTCETLLMCIV 2481
Query: 2488 TVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADL 2547
TVL+ GLR+GGGVGDVLR+PSK+EPLFAARV+YDLLF+F+VIIIVLNLIFGVIIDTFADL
Sbjct: 2482 TVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADL 2541
Query: 2548 RSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEY 2607
RSEKQKKEEILKTTCFICGLERDKFDNKTV+FEEHIK EHNMWHYL FIVLVKVKD TEY
Sbjct: 2542 RSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEY 2601
Query: 2608 TGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQL 2667
TGPESYVA+MI E+NLDWFPRMRAMSLVS++ + EQNE+R+LQEKLESTM LV LSGQL
Sbjct: 2602 TGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQL 2661
Query: 2668 AELKEQMTEQRKNKQRLGFLGSNTPHVN 2695
+ELK+QMTEQRK KQR+G LG + PH+N
Sbjct: 2662 SELKDQMTEQRKQKQRIGLLG-HPPHMN 2688
>gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo
sapiens]
Length = 2671
Score = 3421 bits (8871), Expect = 0.0
Identities = 1765/2728 (64%), Positives = 2099/2728 (76%), Gaps = 111/2728 (4%)
Query: 4 KMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPM 63
+MSSFL+IGDIVSLYAEGSVNGFISTLGLVDDRCVV P AGDL NPPKKFRDCLFKVCPM
Sbjct: 3 EMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPM 62
Query: 64 NRYSAQKQYWKAKQAKQGNH--TEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVI 121
NRYSAQKQYWKAKQ KQ + LL+KLQHAA++EQKQN++ENKK+ G++VKY +VI
Sbjct: 63 NRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVI 122
Query: 122 QLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDK 181
QLLH+KSNKYLTVNKRLPALLEKNAMRV+LDA GNEGSW +I PFWKLRS GDN+VVGDK
Sbjct: 123 QLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDK 182
Query: 182 VVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVR 241
V+L PVNAGQPLHASN EL DN GCKEVN+VNCNTSWKI LFM++ + E+VLKGGDVVR
Sbjct: 183 VILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVR 242
Query: 242 LFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNS 301
LFHAEQEKFLTCDEY+ K +FLRTTLRQSATSATSS ALWE+EVVHHDPCRGGAG WN
Sbjct: 243 LFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNG 302
Query: 302 LFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHGN 361
L+RFKHLATGNYLAAE NP Y+ ++ K G + + R AGEKI Y LV+VPHGN
Sbjct: 303 LYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGR-RNAGEKIKYCLVAVPHGN 361
Query: 362 DIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQ 421
DIASLFELD TTLQ+ D VPRNSYVRLRHLCTNTW+ ST++PID +EERP+ L +GTC
Sbjct: 362 DIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCP 421
Query: 422 TKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLIF 481
TKEDKEAFAIVSVP+SE+RDLDFANDA+ +LA+ V+KL G I+QN+RRFV +LLEDL+F
Sbjct: 422 TKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVF 481
Query: 482 FVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLEDL 541
FV+DVPNNGQ VLD+++TKPNRERQKLMREQNIL QVFGILKAPF+EK GEG ++RLE+L
Sbjct: 482 FVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEEL 541
Query: 542 GDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHN 601
DQ+ APY++M RLCYRVLRHSQ+DYRKNQE+IAK F +MQSQIGYDILAEDTITALLHN
Sbjct: 542 SDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHN 601
Query: 602 NRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGN 661
NRKLLEKHIT E+ETFVSL+R+NREPRFLDYLSDLCVSN AIPVTQELICK +L P N
Sbjct: 602 NRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKN 661
Query: 662 ADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTK 721
+DILI+T++ ++ + LS + +EEVWL W D N E H K++R LAQEA+ G
Sbjct: 662 SDILIRTELRPVK-EMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNA 720
Query: 722 ADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRL 781
D VL+YYRYQL LFARMCLDRQYLAI++IS QL VDLI C++DE LPFDLRASFC L
Sbjct: 721 HDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASFCHL 780
Query: 782 MLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEY 841
MLH+HVDRDPQE V PV++ARLWTEIPT ITI +YDS ++SR+D K KFA TMEFVE+Y
Sbjct: 781 MLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFVEDY 840
Query: 842 LKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMS 901
L VV++ PF ++EKNKLTFEVV LA NLIYFGFYSFSELLRLTRTLL I+D VQ P +
Sbjct: 841 LNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPA 900
Query: 902 SYFERLSKFQD-GGNNVMRTIHGVGEMMTQMVLSR-GSIFPM-SVPDVPPSIHPSKQGSP 958
L ++D GG NV R+I GVG MM+ MVLSR S+F S+ + P +
Sbjct: 901 ----MLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKF 956
Query: 959 TEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTL 1018
E+ED+ VM+TKLKI+EILQFIL+VRLDYRISY+LS++KKEF E ++ A G+
Sbjct: 957 EENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAF 1016
Query: 1019 LPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQ 1078
+ ++D I QAE MF K + +++DDEGGR FLRVLIHL MHDY PL+SGALQ
Sbjct: 1017 DSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQ 1076
Query: 1079 LLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYEN 1138
LLFKHFSQR E + FKQVQLL+S QDV+NYK IK++LD+LR VEKSELWV+K + +
Sbjct: 1077 LLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKG 1136
Query: 1139 GEIGESQVKGGEE-PIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNK 1197
E+ K +E P +E L P + S NY+IVK IL RL+K+C +
Sbjct: 1137 EEVEAGAAKDKKERPTDEEGFLHPPGE---------KSSENYQIVKGILERLNKMCGVGE 1187
Query: 1198 KCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLH 1257
+ R + QRLLKNM AH V+LDLLQIPY+K D KM E++ H FLQ FC GNP NQ LLH
Sbjct: 1188 QMRKKQQRLLKNMDAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLH 1247
Query: 1258 KHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIV 1317
KHL+LFLTPGLLEAETM+HIF+NNY LC+EISE V+QHFVH + THGRHV+YL FL T++
Sbjct: 1248 KHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVI 1307
Query: 1318 KADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHIT 1377
KA+GKYVKKCQDM+MTEL N G+DV++FYND+AS LL MM + RD ++ PL YHI+
Sbjct: 1308 KAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHIS 1367
Query: 1378 LVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVE 1437
LV+LLAAC EGKNVYTEIKC SLLPL+D+V VVTH+DCI EVK+AYVNFVNHCYVDTEVE
Sbjct: 1368 LVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVE 1427
Query: 1438 MKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSD 1497
MKEIYTSNHIW LFENF +DMARVC + +++ AD LEK V +++ ++ FF+SPFS+
Sbjct: 1428 MKEIYTSNHIWTLFENFTLDMARVC-SKREKRVADPTLEKYVLSVVLDTINAFFSSPFSE 1486
Query: 1498 NSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDS 1557
NSTSLQTHQ + +QLLQS R+ C W K SVE+CIRTLA VAK R I +P+DLD+
Sbjct: 1487 NSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDA 1546
Query: 1558 QVNTLFMK--SHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEH 1615
++++ S + QR A ++ + R+ PR WDY+NIIEKLQD++ +LE
Sbjct: 1547 HISSMLSSGASCAAAAQRNASSYKATTRAFPRVTPTAN--QWDYKNIIEKLQDIITALEE 1604
Query: 1616 QFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKLMEKEEKLCIK 1673
+ P++QAE SVLVDVL+ PELLF EGS+A RC G F+SKLI HTK LME EEKLCIK
Sbjct: 1605 RLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIK 1664
Query: 1674 ILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQ 1733
+L+TL++ML KK + + GN LRK+LL Y + S G L +G
Sbjct: 1665 VLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTS-RGDLPDPIG---------TGL 1714
Query: 1734 DSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSF 1793
D D I+ + QC LDKEGA++LV D+I +TKN++IF E I L I LL+GGNT+ Q SF
Sbjct: 1715 DPDWSAIAAT--QCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIHLLDGGNTEIQKSF 1772
Query: 1794 YQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVR 1853
+ + KKSE+FFKVL+DRMK AQ+E +STV VN DLG++ +D R V
Sbjct: 1773 HNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHED---------REPVD 1823
Query: 1854 DSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSP 1913
+T KG++ S S + R + P + G+ + + M
Sbjct: 1824 PTT-------KGRVASFSIPGSSS----RYSLGPSL-------RRGHEVSERVQSSEMGT 1865
Query: 1914 AIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLL 1973
++ IMQPILRFLQLLCENHNR+LQNFLR QNNKTNYNLVCETLQFLD +CGSTTGGLGLL
Sbjct: 1866 SVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLL 1925
Query: 1974 GLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYR 2033
GLYINE NV LV Q LE+LTEYCQGPCHENQTCI THESNGIDII ALILNDI+PL KYR
Sbjct: 1926 GLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYR 1985
Query: 2034 MDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDE 2093
MDLVLQLK+NASKLLLA+MESRHDSENAERIL ++RP+ELVDV+K AY Q ++E
Sbjct: 1986 MDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQ-------EEE 2038
Query: 2094 GGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKP------------------------- 2128
+ VSP++VGHNIYILA QL+RHNK LQ +LKP
Sbjct: 2039 RENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQ 2098
Query: 2129 ---GSDP--DEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNT 2183
S P +E ++ L YY NHT+QIEIVR DR+MEQIVFPVP IC++LT E+K R+F T
Sbjct: 2099 MLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTT 2158
Query: 2184 TERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLA 2243
TE+DEQGSKV+DFF Q+ L+NEM+WQ+K+R+ P ++WFSR ++LWGSISFNLAVFIN+
Sbjct: 2159 TEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINII 2218
Query: 2244 VALFYPFGDDGDEGTL-SPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTI 2302
+A FYP+ + G L SPL S+L WI IC S+ F+K IRP +V+++LRSIY +
Sbjct: 2219 IAFFYPYMEGASTGVLDSPLISLLFWI--LICFSIAALFTKRYSIRPLIVALILRSIYYL 2276
Query: 2303 GLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFV 2362
G+GPTL +LGA NL NKIVF+VSFVGNRGTF RGY+A+++DM FLYHV Y+L +LGLF
Sbjct: 2277 GIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFA 2336
Query: 2363 HEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFT 2422
HE FYS LLFDL+YREETL NVIKSVTRNGRSI+LTA+LALILVYLFSI+GFLFLKDDF
Sbjct: 2337 HELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFI 2396
Query: 2423 MEVDRLKNRTPVTGSHQVPTMTLTTMMEACA--KENCSPTIPASNTADEEYE-DGIERTC 2479
+EVDRL N +P ++ C+ K +C + +E+ E D ER C
Sbjct: 2397 LEVDRLPNNHSTASPLGMP-HGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTERAC 2455
Query: 2480 DTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGV 2539
DTLLMCIVTV+N GLRNGGGVGD+LR+PSKDE LF ARVVYDLLF+FIVIIIVLNLIFGV
Sbjct: 2456 DTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGV 2515
Query: 2540 IIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLV 2599
IIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIK EHNMW+YLYFIVLV
Sbjct: 2516 IIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLV 2575
Query: 2600 KVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSL 2659
+VK+ T+YTGPESYVAQMI KNLDWFPRMRAMSLVSNEG+ EQNEIR LQ+KL STM L
Sbjct: 2576 RVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMKL 2635
Query: 2660 VKQLSGQLAELKEQMTEQRKNKQRLGFL 2687
V L+ QL ELKEQMTEQRK +QRLGF+
Sbjct: 2636 VSHLTAQLNELKEQMTEQRKRRQRLGFV 2663
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 167 bits (423), Expect = 1e-40
Identities = 92/291 (31%), Positives = 155/291 (53%), Gaps = 47/291 (16%)
Query: 2337 YRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSII 2396
+ + D +FLY Y+++ +LG + + FF++ L D+ +TL ++ SVT NG+ ++
Sbjct: 4776 FGVIFTDNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLV 4834
Query: 2397 LTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKEN 2456
+T L ++VYL++++ F F + + D
Sbjct: 4835 MTVGLLAVVVYLYTVVAFNFFRKFYNKSED------------------------------ 4864
Query: 2457 CSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAA 2516
ED + CD ++ C + + G+R GGG+GD + P+ DE
Sbjct: 4865 ---------------EDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDE-YELY 4908
Query: 2517 RVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKT 2576
RVV+D+ F+F VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD
Sbjct: 4909 RVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTP 4968
Query: 2577 VSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFP 2627
FE H EHN+ +Y++F++ + KD TE+TG ESYV +M E+ D+FP
Sbjct: 4969 HGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5019
Score = 101 bits (252), Expect = 9e-21
Identities = 138/595 (23%), Positives = 235/595 (39%), Gaps = 97/595 (16%)
Query: 117 YSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSL--DAAGNEGSWFYIHPFWKLRSEGD 174
Y + I L H S YL+ ++ +K A V L DA G E W+ +HP K RSEG+
Sbjct: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATG-EACWWTMHPASKQRSEGE 160
Query: 175 NIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVL 234
+ VGD ++L+ V++ + LH S G +V+A T W + S E +
Sbjct: 161 KVRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFV 213
Query: 235 KGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRG 294
GG V+RLFH ++ LT + R + T +++LW +E + G
Sbjct: 214 TGGHVLRLFHGHMDECLTISPADSDDQ--RRLVYYEGGAVCTHARSLWRLEPLRIS-WSG 270
Query: 295 GAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTL 354
+W R +H+ TG YLA +++G V D + K + +
Sbjct: 271 SHLRWGQPLRVRHVTTGQYLAL--------TEDQGLVVVD-----ASKAHTKATSFCFRI 317
Query: 355 VSVPHGNDIASLFELDATTLQRADCLVP-----RNSYVRLRHLCTNTWVTSTSIPIDTDE 409
S +LD + + + P S ++H+ + W+T +
Sbjct: 318 ----------SKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA------- 360
Query: 410 ERPVMLKIGTCQTK-------EDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLEN- 461
P L++G + K +A ++ E + + N + +K L++
Sbjct: 361 PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420
Query: 462 -----------GTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMR 510
GT E V L+DLI + + Q + R RQ L +
Sbjct: 421 SGKPRGSGPPAGTALPIEG--VILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQ 478
Query: 511 EQNILAQVFGIL--------KAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRH 562
E+ +L+ V + A F E AGE + +K ++ L Y +L
Sbjct: 479 EEGMLSMVLNCIDRLNVYTTAAHFAEFAGE-----------EAAESWKEIVNLLYELLAS 527
Query: 563 SQQDYRKNQEYIAKNFCVMQSQI----GYDILAEDTITALLHNNRKLLEKHITAKEIETF 618
+ R N + N + S++ + E L+ + L I I++
Sbjct: 528 LIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSI 585
Query: 619 VSLL-RRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVS 672
+SLL + R + LD L LCV N A+ Q+LI + +L PG ++L+QT +++
Sbjct: 586 ISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLL-PGR-ELLLQTNLIN 638
Score = 74.3 bits (181), Expect = 1e-12
Identities = 127/548 (23%), Positives = 209/548 (38%), Gaps = 153/548 (27%)
Query: 1746 QCLLDKEGASELVIDVIVNTKNDR--IFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKS 1803
Q L GA+E+V+ +I K + + S + LGI++L GGN + Q L + KK
Sbjct: 3761 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKD-KKE 3819
Query: 1804 EKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGM 1863
FF+ + M+ S + +N + NK EG+
Sbjct: 3820 VGFFQSIQALMQTC-----SVLDLNAFERQNKA------------------------EGL 3850
Query: 1864 KGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILR 1923
G + E + ++ N E+ A++ Q + R
Sbjct: 3851 -GMVNEDGTVINRQ----------------------NGEKVMADD-------EFTQDLFR 3880
Query: 1924 FLQLLCENHNRELQNFLRNQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL--- 1973
FLQLLCE HN + QN+LR Q N T N++ T+ +L + S + G ++
Sbjct: 3881 FLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQ 3940
Query: 1974 GLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYR 2033
G K +++ Q SLTEY QGPC NQ +A S D ++ + + + K
Sbjct: 3941 GKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLA--HSRLWDAVVGFLHVFAHMMMKLA 3998
Query: 2034 MDL--------VLQLKNNASKLLLAIMESR---------------HDSENAERIL--FNM 2068
D +L L+ + +LL+++E S N E IL F+M
Sbjct: 3999 QDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDM 4058
Query: 2069 ------------------RPRELV---DVMKNAYNQG----------LECDHGD------ 2091
PR L+ D K +Q L C D
Sbjct: 4059 FLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMIN 4118
Query: 2092 -DEGGDDGVSP-KDVGHNIYILAHQLAR---HNKLLQQMLKPGSDPDEGDEALKYYANHT 2146
+E + P +D+G N+ +L L+ H+ L L + + L+Y+ +
Sbjct: 4119 CEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFL------ELAESILEYFRPYL 4172
Query: 2147 AQIEIVRHDRTMEQIVFPV--PNICEY---LTRESKCR-VFNTTERDEQGSKVNDFFQQT 2200
+IEI+ R +E+I F + N ++ +ESK + +F+ + K+ F
Sbjct: 4173 GRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFC 4232
Query: 2201 EDLYNEMK 2208
ED EM+
Sbjct: 4233 EDTIFEMQ 4240
Score = 46.6 bits (109), Expect = 3e-04
Identities = 32/143 (22%), Positives = 66/143 (46%), Gaps = 6/143 (4%)
Query: 1207 LKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLFLTP 1266
+ + ++ + E+ E E++NL + L + RGN N L +L+ ++
Sbjct: 490 IDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFSTNLDWLVSK 549
Query: 1267 -GLLEA-----ETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD 1320
LEA E + + + + + N I E ++ + ++ HGR+ + L L ++ +
Sbjct: 550 LDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCN 609
Query: 1321 GKYVKKCQDMVMTELINGGEDVL 1343
G V+ QD++ L+ G E +L
Sbjct: 610 GVAVRSNQDLITENLLPGRELLL 632
Score = 34.7 bits (78), Expect = 1.3
Identities = 20/74 (27%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 1194 VQNKKCRNQHQRLLKNMGAHSVVLDLLQIPY---EKNDEKMNEVMNLAHTFLQNFCRGNP 1250
+ N K QH L++ +G H V++++ E + + +++ FL FCR +
Sbjct: 2185 IMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISR 2244
Query: 1251 QNQVLLHKHLNLFL 1264
QNQ + HL+ L
Sbjct: 2245 QNQRSMFDHLSYLL 2258
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 167 bits (423), Expect = 1e-40
Identities = 92/291 (31%), Positives = 155/291 (53%), Gaps = 47/291 (16%)
Query: 2337 YRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSII 2396
+ + D +FLY Y+++ +LG + + FF++ L D+ +TL ++ SVT NG+ ++
Sbjct: 4781 FGVIFTDNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLV 4839
Query: 2397 LTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKEN 2456
+T L ++VYL++++ F F + + D
Sbjct: 4840 MTVGLLAVVVYLYTVVAFNFFRKFYNKSED------------------------------ 4869
Query: 2457 CSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAA 2516
ED + CD ++ C + + G+R GGG+GD + P+ DE
Sbjct: 4870 ---------------EDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDE-YELY 4913
Query: 2517 RVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKT 2576
RVV+D+ F+F VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD
Sbjct: 4914 RVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTP 4973
Query: 2577 VSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFP 2627
FE H EHN+ +Y++F++ + KD TE+TG ESYV +M E+ D+FP
Sbjct: 4974 HGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
Score = 101 bits (252), Expect = 9e-21
Identities = 138/595 (23%), Positives = 235/595 (39%), Gaps = 97/595 (16%)
Query: 117 YSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSL--DAAGNEGSWFYIHPFWKLRSEGD 174
Y + I L H S YL+ ++ +K A V L DA G E W+ +HP K RSEG+
Sbjct: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATG-EACWWTMHPASKQRSEGE 160
Query: 175 NIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVL 234
+ VGD ++L+ V++ + LH S G +V+A T W + S E +
Sbjct: 161 KVRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFV 213
Query: 235 KGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRG 294
GG V+RLFH ++ LT + R + T +++LW +E + G
Sbjct: 214 TGGHVLRLFHGHMDECLTISPADSDDQ--RRLVYYEGGAVCTHARSLWRLEPLRIS-WSG 270
Query: 295 GAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTL 354
+W R +H+ TG YLA +++G V D + K + +
Sbjct: 271 SHLRWGQPLRVRHVTTGQYLAL--------TEDQGLVVVD-----ASKAHTKATSFCFRI 317
Query: 355 VSVPHGNDIASLFELDATTLQRADCLVP-----RNSYVRLRHLCTNTWVTSTSIPIDTDE 409
S +LD + + + P S ++H+ + W+T +
Sbjct: 318 ----------SKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA------- 360
Query: 410 ERPVMLKIGTCQTK-------EDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLEN- 461
P L++G + K +A ++ E + + N + +K L++
Sbjct: 361 PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420
Query: 462 -----------GTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMR 510
GT E V L+DLI + + Q + R RQ L +
Sbjct: 421 SGKPRGSGPPAGTALPIEG--VILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQ 478
Query: 511 EQNILAQVFGIL--------KAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRH 562
E+ +L+ V + A F E AGE + +K ++ L Y +L
Sbjct: 479 EEGMLSMVLNCIDRLNVYTTAAHFAEFAGE-----------EAAESWKEIVNLLYELLAS 527
Query: 563 SQQDYRKNQEYIAKNFCVMQSQI----GYDILAEDTITALLHNNRKLLEKHITAKEIETF 618
+ R N + N + S++ + E L+ + L I I++
Sbjct: 528 LIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSI 585
Query: 619 VSLL-RRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVS 672
+SLL + R + LD L LCV N A+ Q+LI + +L PG ++L+QT +++
Sbjct: 586 ISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLL-PGR-ELLLQTNLIN 638
Score = 74.3 bits (181), Expect = 1e-12
Identities = 127/548 (23%), Positives = 209/548 (38%), Gaps = 153/548 (27%)
Query: 1746 QCLLDKEGASELVIDVIVNTKNDR--IFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKS 1803
Q L GA+E+V+ +I K + + S + LGI++L GGN + Q L + KK
Sbjct: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKD-KKE 3824
Query: 1804 EKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGM 1863
FF+ + M+ S + +N + NK EG+
Sbjct: 3825 VGFFQSIQALMQTC-----SVLDLNAFERQNKA------------------------EGL 3855
Query: 1864 KGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILR 1923
G + E + ++ N E+ A++ Q + R
Sbjct: 3856 -GMVNEDGTVINRQ----------------------NGEKVMADD-------EFTQDLFR 3885
Query: 1924 FLQLLCENHNRELQNFLRNQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL--- 1973
FLQLLCE HN + QN+LR Q N T N++ T+ +L + S + G ++
Sbjct: 3886 FLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQ 3945
Query: 1974 GLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYR 2033
G K +++ Q SLTEY QGPC NQ +A S D ++ + + + K
Sbjct: 3946 GKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLA--HSRLWDAVVGFLHVFAHMMMKLA 4003
Query: 2034 MDL--------VLQLKNNASKLLLAIMESR---------------HDSENAERIL--FNM 2068
D +L L+ + +LL+++E S N E IL F+M
Sbjct: 4004 QDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDM 4063
Query: 2069 ------------------RPRELV---DVMKNAYNQG----------LECDHGD------ 2091
PR L+ D K +Q L C D
Sbjct: 4064 FLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMIN 4123
Query: 2092 -DEGGDDGVSP-KDVGHNIYILAHQLAR---HNKLLQQMLKPGSDPDEGDEALKYYANHT 2146
+E + P +D+G N+ +L L+ H+ L L + + L+Y+ +
Sbjct: 4124 CEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFL------ELAESILEYFRPYL 4177
Query: 2147 AQIEIVRHDRTMEQIVFPV--PNICEY---LTRESKCR-VFNTTERDEQGSKVNDFFQQT 2200
+IEI+ R +E+I F + N ++ +ESK + +F+ + K+ F
Sbjct: 4178 GRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFC 4237
Query: 2201 EDLYNEMK 2208
ED EM+
Sbjct: 4238 EDTIFEMQ 4245
Score = 46.6 bits (109), Expect = 3e-04
Identities = 32/143 (22%), Positives = 66/143 (46%), Gaps = 6/143 (4%)
Query: 1207 LKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLFLTP 1266
+ + ++ + E+ E E++NL + L + RGN N L +L+ ++
Sbjct: 490 IDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFSTNLDWLVSK 549
Query: 1267 -GLLEA-----ETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD 1320
LEA E + + + + + N I E ++ + ++ HGR+ + L L ++ +
Sbjct: 550 LDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCN 609
Query: 1321 GKYVKKCQDMVMTELINGGEDVL 1343
G V+ QD++ L+ G E +L
Sbjct: 610 GVAVRSNQDLITENLLPGRELLL 632
Score = 34.7 bits (78), Expect = 1.3
Identities = 20/74 (27%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 1194 VQNKKCRNQHQRLLKNMGAHSVVLDLLQIPY---EKNDEKMNEVMNLAHTFLQNFCRGNP 1250
+ N K QH L++ +G H V++++ E + + +++ FL FCR +
Sbjct: 2185 IMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISR 2244
Query: 1251 QNQVLLHKHLNLFL 1264
QNQ + HL+ L
Sbjct: 2245 QNQRSMFDHLSYLL 2258
>gi|126032338 ryanodine receptor 3 [Homo sapiens]
Length = 4870
Score = 167 bits (423), Expect = 1e-40
Identities = 93/288 (32%), Positives = 151/288 (52%), Gaps = 47/288 (16%)
Query: 2340 VILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTA 2399
V D +FLY Y + +LG + + FF++ L D+ +TL ++ SVT NG+ ++LT
Sbjct: 4616 VFTDNSFLYLAWYTTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTV 4674
Query: 2400 VLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSP 2459
L ++VYL++++ F F + + D
Sbjct: 4675 GLLAVVVYLYTVVAFNFFRKFYNKSED--------------------------------- 4701
Query: 2460 TIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVV 2519
+D + CD ++ C + + G+R GGG+GD + P+ D P R+V
Sbjct: 4702 ------------DDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD-PYEMYRIV 4748
Query: 2520 YDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSF 2579
+D+ F+F VI+I+L +I G+IID F +LR ++++ E ++T CFICG+ D FD F
Sbjct: 4749 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGF 4808
Query: 2580 EEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFP 2627
E H EHN+ +YL+F++ + KD TE+TG ESYV +M E+ D+FP
Sbjct: 4809 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 4856
Score = 119 bits (298), Expect = 4e-26
Identities = 140/581 (24%), Positives = 245/581 (42%), Gaps = 73/581 (12%)
Query: 117 YSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSL-DAAGNEGSWFYIHPFWKLRSEGDN 175
Y + + L H S YLT + +K A V L + A E W+ IHP K RSEG+
Sbjct: 105 YGHAVLLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEK 164
Query: 176 IVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLK 235
+ +GD ++L+ V++ + LH S + G +V+A T W + SS E L
Sbjct: 165 VRIGDDLILVSVSSERYLHLS-----VSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLL 219
Query: 236 GGDVVRLFHAEQEKF-LTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRG 294
GG VVRLFH E + + QH R ++ + T +++LW +E + G
Sbjct: 220 GGHVVRLFHGHDECLTIPSTDQNDSQH---RRIFYEAGGAGTRARSLWRVEPLRIS-WSG 275
Query: 295 GAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKR---QAGEKIM 351
+W FR +HL TG+YLA +++G ++D +K +A +++
Sbjct: 276 SNIRWGQAFRLRHLTTGHYLAL--------TEDQGLILQDRAKSDTKSTAFSFRASKELK 327
Query: 352 YTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEER 411
L S H DI + ++ D S ++H+ + WVT + T
Sbjct: 328 EKLDS-SHKRDIEG---MGVPEIKYGD------SVCFVQHIASGLWVTYKAQDAKTSRLG 377
Query: 412 PVMLKI-----------GTCQTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLE 460
P+ K+ T Q + +E+ A + + F + N+ A +E
Sbjct: 378 PLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFVSGNNRTAAPITLPIE 437
Query: 461 NGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFG 520
V + L+DLI + + + + RQ L +E+ +LA V
Sbjct: 438 E----------VLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLN 487
Query: 521 IL-KAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVL-------RHSQQDYRKNQE 572
+ + + + E+ G +K +L L Y++L R++ + N +
Sbjct: 488 CIDRLNVYNSVAHFAGIAREESG----MAWKEILNLLYKLLAALIRGNRNNCAQFSNNLD 543
Query: 573 YIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLL-RRNREPRFL 631
++ ++S G IL + + +L + + L I I++ +SLL + R + L
Sbjct: 544 WLISKLDRLESSSG--IL--EVLHCILTESPEALNL-IAEGHIKSIISLLDKHGRNHKVL 598
Query: 632 DYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVS 672
D L LC+ N A+ Q LIC +L N +L+QT++++
Sbjct: 599 DILCSLCLCNGVAVRANQNLICDNLLPRRN--LLLQTRLIN 637
Score = 80.1 bits (196), Expect = 3e-14
Identities = 121/551 (21%), Positives = 209/551 (37%), Gaps = 149/551 (27%)
Query: 1746 QCLLDKEGASELVIDVIVNTKNDR--IFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKS 1803
Q L + GA+E+V+ +I +K + + E + LGIA+L GGN Q L E KK
Sbjct: 3618 QARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKE-KKD 3676
Query: 1804 EKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGM 1863
FF+ L M++ S + +N + NK G M + TL ++E
Sbjct: 3677 AGFFQSLSGLMQSC-----SVLDLNAFERQNK---------AEGLGMVTEEGTLIVRE-- 3720
Query: 1864 KGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILR 1923
E+V + + + R
Sbjct: 3721 -----------------------------------------RGEKVLQNDEFT--RDLFR 3737
Query: 1924 FLQLLCENHNRELQNFLRNQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL--- 1973
FLQLLCE HN + QNFLR Q N T N++ T+ +L + S + G ++
Sbjct: 3738 FLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDES 3797
Query: 1974 GLYINEKNVALVNQNLESLTEYCQGPCHENQTCIA----------------------THE 2011
G + K +A+ Q SLTEY QGPC NQ +A + +
Sbjct: 3798 GQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQD 3857
Query: 2012 SNGIDIIIAL--ILNDI--------------NPLGKYRMDLVLQLKNNASKLL------- 2048
S+ I+++ L +L D+ +GK +D +++ N +L
Sbjct: 3858 SSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFL 3917
Query: 2049 ----LAIMESRHDSENAERILFNMRPRELVDVMKNAYNQG-----LECDHGDDEGGDDGV 2099
L ++ + + + + + + + + Y Q L C D+ + V
Sbjct: 3918 KLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYV 3977
Query: 2100 S--------PKDVGHNIYILAHQLARH---NKLLQQMLKPGSDPDEGDEALKYYANHTAQ 2148
KD+G N+ +L L+ H + L+ +L P + L Y+ + +
Sbjct: 3978 DFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDP------AESVLNYFEPYLGR 4031
Query: 2149 IEIVRHDRTMEQIVFPVPNIC-----EYLTRESKCR-VFNTTERDEQGSKVNDFFQQTED 2202
IEI+ + +E++ F + + +ESK + +F+ + K+ F ED
Sbjct: 4032 IEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCED 4091
Query: 2203 LYNEMKWQKKI 2213
EM+ +I
Sbjct: 4092 TIFEMQLASQI 4102
Score = 38.1 bits (87), Expect = 0.12
Identities = 36/164 (21%), Positives = 69/164 (42%), Gaps = 24/164 (14%)
Query: 1195 QNK-KCRNQHQRLLKNMGAHSVVLDLLQ-------------IPYEKNDEKMNEVMNLAHT 1240
QNK + Q L K G ++VL+ + I E++ E++NL +
Sbjct: 463 QNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYK 522
Query: 1241 FLQNFCRGNPQNQVLLHKHLNLFL--------TPGLLEAETMRHIFMNNYHLCNEISERV 1292
L RGN N +L+ + + G+L E + I + N I+E
Sbjct: 523 LLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGIL--EVLHCILTESPEALNLIAEGH 580
Query: 1293 VQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELI 1336
++ + ++ HGR+ + L L ++ +G V+ Q+++ L+
Sbjct: 581 IKSIISLLDKHGRNHKVLDILCSLCLCNGVAVRANQNLICDNLL 624
Score = 37.4 bits (85), Expect = 0.20
Identities = 21/73 (28%), Positives = 38/73 (52%), Gaps = 2/73 (2%)
Query: 1194 VQNKKCRNQHQRLLKNMGAHSVVLDLL--QIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQ 1251
+ N K QH L++ +G H V++++ + EK+ +++ FL FCR + Q
Sbjct: 2047 IMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYFCRISRQ 2106
Query: 1252 NQVLLHKHLNLFL 1264
NQ + +HL+ L
Sbjct: 2107 NQKAMFEHLSYLL 2119
>gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]
Length = 4967
Score = 164 bits (415), Expect = 1e-39
Identities = 92/288 (31%), Positives = 152/288 (52%), Gaps = 47/288 (16%)
Query: 2340 VILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTA 2399
V D +FLY Y+ + +LG + + FF++ L D+ +TL ++ SVT NG+ ++LT
Sbjct: 4713 VFTDNSFLYLAWYMTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTV 4771
Query: 2400 VLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSP 2459
L ++VYL++++ F F + + D
Sbjct: 4772 GLLAVVVYLYTVVAFNFFRKFYNKSEDG-------------------------------- 4799
Query: 2460 TIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVV 2519
D + CD +L C + + G+R GGG+GD + P+ DE R++
Sbjct: 4800 -------------DTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDE-YEIYRII 4845
Query: 2520 YDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSF 2579
+D+ F+F VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 4846 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGF 4905
Query: 2580 EEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFP 2627
E H EHN+ +YL+F++ + KD TE+TG ESYV +M E+ ++FP
Sbjct: 4906 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP 4953
Score = 105 bits (261), Expect = 8e-22
Identities = 153/624 (24%), Positives = 261/624 (41%), Gaps = 88/624 (14%)
Query: 87 ALLKKLQHAAELEQKQNESENKKLLGEIVK--------YSNVIQLLHIKSNKYLTVNKRL 138
AL + L + E + Q + E K + + + Y + I L H S YL
Sbjct: 77 ALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTS 136
Query: 139 PALLEKNAMRVSL--DAAGNEGSWFYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHAS 196
+ +K A V L D G E W+ IHP K RSEG+ + VGD ++L+ V++ + LH S
Sbjct: 137 RSSTDKLAFDVGLQEDTTG-EACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLS 195
Query: 197 NIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLT--CD 254
G V+A T W + S + L GGDV+RL H ++ LT
Sbjct: 196 Y-----GNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSG 250
Query: 255 EYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYL 314
E+ ++Q RT + + +++LW +E + G +W FR +H+ TG YL
Sbjct: 251 EHGEEQR---RTVHYEGGAVSVHARSLWRLETL-RVAWSGSHIRWGQPFRLRHVTTGKYL 306
Query: 315 AAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTL 374
+ + + E +V+ T+ R + EK+ D+ E+D
Sbjct: 307 SLMEDKNLLLMDKEKADVKS----TAFTFRSSKEKL-----------DVGVRKEVDGMGT 351
Query: 375 QRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSV 434
+ +S ++H+ T W+T S+ + + +++G+ Q K +
Sbjct: 352 SE---IKYGDSVCYIQHVDTGLWLTYQSVDVKS-------VRMGSIQRKAIMHHEGHMDD 401
Query: 435 PLSEVRDLDFANDANKVLATTV--------------KKLENGTITQNERRFVTKLLEDLI 480
+S R + +V+ +TV KK + T+ V+ L+DLI
Sbjct: 402 GISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTV-DLPIESVSLSLQDLI 460
Query: 481 FFVADVPNNGQEVLDVVITKPNR-----ERQKLMREQNILAQVFGIL-KAPFKEKAGEGS 534
+ P+ E D K NR RQ L +E+ ++ V + + A +
Sbjct: 461 GYF-HPPDEHLEHED----KQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFA 515
Query: 535 MLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDT 594
+ + G+ +K +L Y +L + RKN + + + S++ + A
Sbjct: 516 DVAGREAGES----WKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRL-ERLEASSG 570
Query: 595 ITALLHNNRKLLEKH-----ITAKEIETFVSLL-RRNREPRFLDYLSDLCVSNTTAIPVT 648
I +LH L+E I I++ +SLL + R + LD L LCV + A+
Sbjct: 571 ILEVLH--CVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSN 628
Query: 649 QELICKFMLSPGNADILIQTKVVS 672
Q LIC +L PG D+L+QT++V+
Sbjct: 629 QHLICDNLL-PGR-DLLLQTRLVN 650
Score = 72.4 bits (176), Expect = 6e-12
Identities = 124/568 (21%), Positives = 211/568 (37%), Gaps = 157/568 (27%)
Query: 1729 SFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDR--IFSEGIFLGIALLEGGN 1786
SF ++ +K + Q L GA+E+V+ I +K + + + + LGIA+L GGN
Sbjct: 3713 SFEEKEMEKQKLLYQ--QARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGN 3770
Query: 1787 TQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTS 1846
+ Q L E KK FF+ L M++ S + +N + NK
Sbjct: 3771 STVQQKMLDYLKE-KKDVGFFQSLAGLMQSC-----SVLDLNAFERQNK----------- 3813
Query: 1847 GPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSA 1906
EG+ G +TE E S
Sbjct: 3814 -------------AEGL-GMVTE---------------------------------EGSG 3826
Query: 1907 EEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQ-NNKTNYNLVCETLQFLDCICGS 1965
E+V + RFLQLLCE HN + QN+LR Q N T N++ T+ +L + S
Sbjct: 3827 EKVLQDDEFTC--DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQES 3884
Query: 1966 TT------GGLGLL---GLYINEKNVALVNQNLESLTEYCQGPCHENQTCIA-------- 2008
+ G ++ G K + + Q +LTEY QGPC NQ +A
Sbjct: 3885 ISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAV 3944
Query: 2009 --------------THESNGIDII----------IALIL-----NDIN-PLGKYRMDLVL 2038
+ +S+ I+++ + ++L N +N +GK +D+++
Sbjct: 3945 VGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLV 4004
Query: 2039 QLKNNASKLL-----------LAIMESRHDSENAERILFNMRPRELVDVMKNAYNQG--- 2084
+ NN +L L ++ + + + + + R Y Q
Sbjct: 4005 ESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETE 4064
Query: 2085 --LECDHGDDEGGDD--------GVSPKDVGHNIYILAHQLARH---NKLLQQMLKPGSD 2131
L C D+ D KD+G N+ +L L+ H + LQ L
Sbjct: 4065 FLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFL----- 4119
Query: 2132 PDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNIC-----EYLTRESKCR-VFNTTE 2185
+ + L Y+ +IEI+ + +E++ F + + +ESK + +F+
Sbjct: 4120 -ELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVN 4178
Query: 2186 RDEQGSKVNDFFQQTEDLYNEMKWQKKI 2213
+ K+ F ED EM+ +I
Sbjct: 4179 EGGEKEKMELFVNFCEDTIFEMQLAAQI 4206
Score = 33.1 bits (74), Expect = 3.8
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 3/74 (4%)
Query: 1194 VQNKKCRNQHQRLLKNMGAHSVVLDLLQIPY---EKNDEKMNEVMNLAHTFLQNFCRGNP 1250
+ N K QH L++ +G H V++++ E + +++ FL FCR +
Sbjct: 2149 IMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISR 2208
Query: 1251 QNQVLLHKHLNLFL 1264
QNQ + HL+ L
Sbjct: 2209 QNQKAMFDHLSYLL 2222
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 36.6 bits (83), Expect = 0.34
Identities = 41/170 (24%), Positives = 78/170 (45%), Gaps = 17/170 (10%)
Query: 1073 LSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEK 1132
L+ + + K +Q+AE LQ ++QL Q+V KQ L EK E+ E
Sbjct: 1040 LNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQ-----KILLFGCEKEEMNKEI 1094
Query: 1133 SSNYENGEIGESQVKGGEEPIEE--SNILSPVQDGTK------KPQIDSNKS-NNYRIVK 1183
+ E G ++ + +E +++ +++ S QD TK K ++D NKS ++
Sbjct: 1095 TWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQ 1154
Query: 1184 EILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNE 1233
E L+ L L ++K+ ++ LK L+ +EK+++ + +
Sbjct: 1155 EQLVELKMLAEEDKRKVSELTSKLKTTDEE---FQSLKSSHEKSNKSLED 1201
>gi|134152674 rabaptin, RAB GTPase binding effector protein 1 isoform
2 [Homo sapiens]
Length = 829
Score = 34.3 bits (77), Expect = 1.7
Identities = 37/155 (23%), Positives = 67/155 (43%), Gaps = 14/155 (9%)
Query: 1606 LQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKL 1663
+++ V EHQF ++ E + S E E +D R R G L N KK
Sbjct: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAER---EIADLRRRLSEGQEEENLENEMKKA 177
Query: 1664 MEKEEKLCIKILQTLREMLEKKDSFVEEGNTLRKI------LLNRYFKGDYSIGVNGHLS 1717
E EKL ++ +E+ KD E + ++++ LN Y + + S + +
Sbjct: 178 QEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMY 237
Query: 1718 GAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKE 1752
A T + S +D++K+ + ++ LL++E
Sbjct: 238 VAVLNTQK---SVLQEDAEKLRKELHEVCHLLEQE 269
Score = 33.1 bits (74), Expect = 3.8
Identities = 17/61 (27%), Positives = 33/61 (54%), Gaps = 2/61 (3%)
Query: 2638 EGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHH 2697
E ++ +NE++ QE E S+V + ++A LK+++TE + L S +NH+
Sbjct: 166 EEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE--ASKVKELNHY 223
Query: 2698 M 2698
+
Sbjct: 224 L 224
>gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isoform 1
[Homo sapiens]
Length = 862
Score = 34.3 bits (77), Expect = 1.7
Identities = 37/155 (23%), Positives = 67/155 (43%), Gaps = 14/155 (9%)
Query: 1606 LQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKL 1663
+++ V EHQF ++ E + S E E +D R R G L N KK
Sbjct: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAER---EIADLRRRLSEGQEEENLENEMKKA 177
Query: 1664 MEKEEKLCIKILQTLREMLEKKDSFVEEGNTLRKI------LLNRYFKGDYSIGVNGHLS 1717
E EKL ++ +E+ KD E + ++++ LN Y + + S + +
Sbjct: 178 QEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMY 237
Query: 1718 GAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKE 1752
A T + S +D++K+ + ++ LL++E
Sbjct: 238 VAVLNTQK---SVLQEDAEKLRKELHEVCHLLEQE 269
Score = 33.1 bits (74), Expect = 3.8
Identities = 17/61 (27%), Positives = 33/61 (54%), Gaps = 2/61 (3%)
Query: 2638 EGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHH 2697
E ++ +NE++ QE E S+V + ++A LK+++TE + L S +NH+
Sbjct: 166 EEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE--ASKVKELNHY 223
Query: 2698 M 2698
+
Sbjct: 224 L 224
>gi|148233596 LPS-responsive vesicle trafficking, beach and anchor
containing [Homo sapiens]
Length = 2863
Score = 33.1 bits (74), Expect = 3.8
Identities = 26/106 (24%), Positives = 50/106 (47%), Gaps = 8/106 (7%)
Query: 885 LTRTLLAILDIVQAPMSSYFERLSKFQDGGNNVM---RTIHGVGEMMTQMVLSRGSIFPM 941
LT L +I +Q S + + F + +NV+ TIH + ++M MV++ G I P+
Sbjct: 1319 LTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPL 1378
Query: 942 SVPDVPPSIHPSKQGSPTE----HEDVTVMDTKLKIIEILQFILSV 983
+ + H + PT+ VT + + ++++L F S+
Sbjct: 1379 -LSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSL 1423
>gi|116812628 coiled-coil domain containing 67 [Homo sapiens]
Length = 604
Score = 33.1 bits (74), Expect = 3.8
Identities = 28/106 (26%), Positives = 46/106 (43%), Gaps = 23/106 (21%)
Query: 2617 MIVEKNLDWFPRMRAMSLVSNEGDSE-----------QNEIRSLQEKLES----TMSLVK 2661
M+ K +DW +MRA+ + D E E+ L++KL+S +++ +
Sbjct: 28 MVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQ 87
Query: 2662 QLSGQLAELKEQMTEQRKN--KQRLGFLGSN------TPHVNHHMP 2699
GQL LK Q ++ N K RL + N PH+ +P
Sbjct: 88 NYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIP 133
>gi|62988331 hypothetical protein LOC55780 [Homo sapiens]
Length = 678
Score = 33.1 bits (74), Expect = 3.8
Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 3/72 (4%)
Query: 1186 LIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNF 1245
L+ + +C +N Q+ + +K++ ++ L + YEKN K NE +NL HT L
Sbjct: 599 LVNIHAVCGKNAHEYQQYLKFVKSILQYTENL-VAYTSYEKN--KWNETINLTHTALLKM 655
Query: 1246 CRGNPQNQVLLH 1257
+ + Q+L+H
Sbjct: 656 WTFSEKKQMLIH 667
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 32.7 bits (73), Expect = 5.0
Identities = 62/304 (20%), Positives = 109/304 (35%), Gaps = 61/304 (20%)
Query: 1676 QTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDS 1735
+ L++ +E +D EE + R D G + HL K A+ +
Sbjct: 401 KNLKKTVEDEDQDSEEEKDNDSYIKER---SDIPSGTSKHLQKKAKKQAKKQAKNQRRQQ 457
Query: 1736 DKMG--ISMSDIQCLLD----KEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQT 1789
G + ++DI C +D E +E+ + VN K++ I EG+
Sbjct: 458 KIQGKVLHLNDI-CTIDHPEDSEYEAEMSLQGEVNIKSNHISQEGVM-----------HK 505
Query: 1790 QYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPR 1849
+Y Q+ + K + + D K+ ++ +D+ N D+D E++TS P
Sbjct: 506 EYCVNQK--DLNGQAKMIESVTDNQKSTEE----------VDMKNINMDNDLEVLTSSPT 553
Query: 1850 MRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEV 1909
+ + +L EG G++ ++ + + I+I+ G K E V
Sbjct: 554 RNLNGA--YLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHTPGT---KVYEVV 608
Query: 1910 TMSPAIAIMQPILRFLQLLCENHNRELQN------------FLRNQNNKTNYNLVCETLQ 1957
P A C NRE+ N F RN+ + L+CE
Sbjct: 609 NEDPETA-----------FCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCT 657
Query: 1958 FLDC 1961
C
Sbjct: 658 RRQC 661
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 32.7 bits (73), Expect = 5.0
Identities = 62/304 (20%), Positives = 109/304 (35%), Gaps = 61/304 (20%)
Query: 1676 QTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDS 1735
+ L++ +E +D EE + R D G + HL K A+ +
Sbjct: 402 KNLKKTVEDEDQDSEEEKDNDSYIKER---SDIPSGTSKHLQKKAKKQAKKQAKNQRRQQ 458
Query: 1736 DKMG--ISMSDIQCLLD----KEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQT 1789
G + ++DI C +D E +E+ + VN K++ I EG+
Sbjct: 459 KIQGKVLHLNDI-CTIDHPEDSEYEAEMSLQGEVNIKSNHISQEGVM-----------HK 506
Query: 1790 QYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPR 1849
+Y Q+ + K + + D K+ ++ +D+ N D+D E++TS P
Sbjct: 507 EYCVNQK--DLNGQAKMIESVTDNQKSTEE----------VDMKNINMDNDLEVLTSSPT 554
Query: 1850 MRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEV 1909
+ + +L EG G++ ++ + + I+I+ G K E V
Sbjct: 555 RNLNGA--YLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHTPGT---KVYEVV 609
Query: 1910 TMSPAIAIMQPILRFLQLLCENHNRELQN------------FLRNQNNKTNYNLVCETLQ 1957
P A C NRE+ N F RN+ + L+CE
Sbjct: 610 NEDPETA-----------FCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCT 658
Query: 1958 FLDC 1961
C
Sbjct: 659 RRQC 662
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 32.7 bits (73), Expect = 5.0
Identities = 62/304 (20%), Positives = 109/304 (35%), Gaps = 61/304 (20%)
Query: 1676 QTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDS 1735
+ L++ +E +D EE + R D G + HL K A+ +
Sbjct: 402 KNLKKTVEDEDQDSEEEKDNDSYIKER---SDIPSGTSKHLQKKAKKQAKKQAKNQRRQQ 458
Query: 1736 DKMG--ISMSDIQCLLD----KEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQT 1789
G + ++DI C +D E +E+ + VN K++ I EG+
Sbjct: 459 KIQGKVLHLNDI-CTIDHPEDSEYEAEMSLQGEVNIKSNHISQEGVM-----------HK 506
Query: 1790 QYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPR 1849
+Y Q+ + K + + D K+ ++ +D+ N D+D E++TS P
Sbjct: 507 EYCVNQK--DLNGQAKMIESVTDNQKSTEE----------VDMKNINMDNDLEVLTSSPT 554
Query: 1850 MRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEV 1909
+ + +L EG G++ ++ + + I+I+ G K E V
Sbjct: 555 RNLNGA--YLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHTPGT---KVYEVV 609
Query: 1910 TMSPAIAIMQPILRFLQLLCENHNRELQN------------FLRNQNNKTNYNLVCETLQ 1957
P A C NRE+ N F RN+ + L+CE
Sbjct: 610 NEDPETA-----------FCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCT 658
Query: 1958 FLDC 1961
C
Sbjct: 659 RRQC 662
>gi|4507691 transformation/transcription domain-associated protein
[Homo sapiens]
Length = 3830
Score = 32.7 bits (73), Expect = 5.0
Identities = 15/42 (35%), Positives = 28/42 (66%), Gaps = 2/42 (4%)
Query: 744 RQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHM 785
RQ+L ++ +S L+V L + + DESLP ++ C+L+L++
Sbjct: 387 RQHLPLSDLS--LAVQLFAKNIDDESLPSSIQTMSCKLLLNL 426
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 32.7 bits (73), Expect = 5.0
Identities = 16/47 (34%), Positives = 29/47 (61%)
Query: 2633 SLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRK 2679
S + E + + E+++LQ +L + VK LS Q+ ELK+++ QR+
Sbjct: 639 SRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRR 685
>gi|5454158 valyl-tRNA synthetase [Homo sapiens]
Length = 1264
Score = 32.7 bits (73), Expect = 5.0
Identities = 23/108 (21%), Positives = 50/108 (46%), Gaps = 5/108 (4%)
Query: 14 IVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYW 73
+V++ A G+ + L DRC +H + L +P ++ K R AQ+Q
Sbjct: 1162 VVAVLALGAPAPQGCAVALASDRCSIHLQLQGLVDPARELGKLQAK-----RVEAQRQAQ 1216
Query: 74 KAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVI 121
+ ++ + + + ++Q A E + +Q E+E +K+ I + ++
Sbjct: 1217 RLRERRAASGYPVKVPLEVQEADEAKLQQTEAELRKVDEAIALFQKML 1264
>gi|194306660 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 32.3 bits (72), Expect = 6.5
Identities = 40/197 (20%), Positives = 86/197 (43%), Gaps = 26/197 (13%)
Query: 1145 QVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNY--RIVKEILIRL----SKLCVQNKK 1198
Q G E E S + + ++P + +S+ + R ++ +++++ ++L Q K
Sbjct: 147 QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL 206
Query: 1199 CRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVM-NLAHTFLQNFCRGNPQNQVLLH 1257
R Q + L+++ H L+ +Q+ +++N K+ E+ NL HT Q LL+
Sbjct: 207 SREQIEGLIEDRRIH---LEEIQVQHQRNQNKIKELTKNLHHT------------QELLY 251
Query: 1258 KHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIV 1317
+ FL + + +L ++I Q+ V C + + + L +
Sbjct: 252 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIK----QYRVQCKKKEDKIGKVLPVMHESH 307
Query: 1318 KADGKYVKKCQDMVMTE 1334
A +Y+K +D ++ E
Sbjct: 308 HAQSEYIKSLKDKLVQE 324
>gi|194306658 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 32.3 bits (72), Expect = 6.5
Identities = 40/197 (20%), Positives = 86/197 (43%), Gaps = 26/197 (13%)
Query: 1145 QVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNY--RIVKEILIRL----SKLCVQNKK 1198
Q G E E S + + ++P + +S+ + R ++ +++++ ++L Q K
Sbjct: 147 QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL 206
Query: 1199 CRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVM-NLAHTFLQNFCRGNPQNQVLLH 1257
R Q + L+++ H L+ +Q+ +++N K+ E+ NL HT Q LL+
Sbjct: 207 SREQIEGLIEDRRIH---LEEIQVQHQRNQNKIKELTKNLHHT------------QELLY 251
Query: 1258 KHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIV 1317
+ FL + + +L ++I Q+ V C + + + L +
Sbjct: 252 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIK----QYRVQCKKKEDKIGKVLPVMHESH 307
Query: 1318 KADGKYVKKCQDMVMTE 1334
A +Y+K +D ++ E
Sbjct: 308 HAQSEYIKSLKDKLVQE 324
>gi|14150165 coiled-coil domain containing 77 isoform a [Homo sapiens]
Length = 488
Score = 32.3 bits (72), Expect = 6.5
Identities = 40/197 (20%), Positives = 86/197 (43%), Gaps = 26/197 (13%)
Query: 1145 QVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNY--RIVKEILIRL----SKLCVQNKK 1198
Q G E E S + + ++P + +S+ + R ++ +++++ ++L Q K
Sbjct: 179 QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL 238
Query: 1199 CRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVM-NLAHTFLQNFCRGNPQNQVLLH 1257
R Q + L+++ H L+ +Q+ +++N K+ E+ NL HT Q LL+
Sbjct: 239 SREQIEGLIEDRRIH---LEEIQVQHQRNQNKIKELTKNLHHT------------QELLY 283
Query: 1258 KHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIV 1317
+ FL + + +L ++I Q+ V C + + + L +
Sbjct: 284 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIK----QYRVQCKKKEDKIGKVLPVMHESH 339
Query: 1318 KADGKYVKKCQDMVMTE 1334
A +Y+K +D ++ E
Sbjct: 340 HAQSEYIKSLKDKLVQE 356
>gi|194306535 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 32.3 bits (72), Expect = 6.5
Identities = 40/197 (20%), Positives = 86/197 (43%), Gaps = 26/197 (13%)
Query: 1145 QVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNY--RIVKEILIRL----SKLCVQNKK 1198
Q G E E S + + ++P + +S+ + R ++ +++++ ++L Q K
Sbjct: 147 QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL 206
Query: 1199 CRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVM-NLAHTFLQNFCRGNPQNQVLLH 1257
R Q + L+++ H L+ +Q+ +++N K+ E+ NL HT Q LL+
Sbjct: 207 SREQIEGLIEDRRIH---LEEIQVQHQRNQNKIKELTKNLHHT------------QELLY 251
Query: 1258 KHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIV 1317
+ FL + + +L ++I Q+ V C + + + L +
Sbjct: 252 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIK----QYRVQCKKKEDKIGKVLPVMHESH 307
Query: 1318 KADGKYVKKCQDMVMTE 1334
A +Y+K +D ++ E
Sbjct: 308 HAQSEYIKSLKDKLVQE 324
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 32.3 bits (72), Expect = 6.5
Identities = 17/77 (22%), Positives = 42/77 (54%)
Query: 1146 VKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQR 1205
+KG +E I + Q + + + + +I + + ++L+KL ++N+ ++ +QR
Sbjct: 96 IKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQR 155
Query: 1206 LLKNMGAHSVVLDLLQI 1222
L++ +G+ L+ +QI
Sbjct: 156 LVEQVGSLQDALEAIQI 172
>gi|226246554 hypothetical protein LOC643677 [Homo sapiens]
Length = 7081
Score = 32.0 bits (71), Expect = 8.5
Identities = 52/229 (22%), Positives = 95/229 (41%), Gaps = 25/229 (10%)
Query: 988 RISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPV 1047
R + +LS + + G+ +ET L ++P I + + GRK+ +
Sbjct: 5847 RTNTILSKFPLQSGKQKTPSETDVDKKTTAHLSLQMLPGIHMDMTEIDPAKGGRKQALLI 5906
Query: 1048 QLDDEGGRTFLRVLIHLIMHDYPP----LLSGALQLLFKHFSQRAEVLQAFKQVQLLVSN 1103
+EG FL + +PP SG L+ KH + A +Q +L + N
Sbjct: 5907 SEQEEGVLEFLPKSL------FPPWTFQFQSGDLE--EKHQTD-ANTNINLEQKKLEMDN 5957
Query: 1104 QDVDNYKQIKADLD---QLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILS 1160
N K+ K + L L EK+E+ +++N E E G P ++LS
Sbjct: 5958 DSTVNQKEGKLKIGTNRALHLQEEKTEMHKARTANLEK-ERGRMDTSSSAHP----HLLS 6012
Query: 1161 -PVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLK 1208
++ K Q+ +++ N+ I+++ + +L N K Q Q+L +
Sbjct: 6013 LKAEESQMKTQVITHRENSRLIMQK---QKKELEASNAKQSIQLQKLFQ 6058
>gi|239750569 PREDICTED: hypothetical protein LOC643677 [Homo sapiens]
Length = 6929
Score = 32.0 bits (71), Expect = 8.5
Identities = 52/229 (22%), Positives = 95/229 (41%), Gaps = 25/229 (10%)
Query: 988 RISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPV 1047
R + +LS + + G+ +ET L ++P I + + GRK+ +
Sbjct: 5695 RTNTILSKFPLQSGKQKTPSETDVDKKTTAHLSLQMLPGIHMDMTEIDPAKGGRKQALLI 5754
Query: 1048 QLDDEGGRTFLRVLIHLIMHDYPP----LLSGALQLLFKHFSQRAEVLQAFKQVQLLVSN 1103
+EG FL + +PP SG L+ KH + A +Q +L + N
Sbjct: 5755 SEQEEGVLEFLPKSL------FPPWTFQFQSGDLE--EKHQTD-ANTNINLEQKKLEMDN 5805
Query: 1104 QDVDNYKQIKADLD---QLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILS 1160
N K+ K + L L EK+E+ +++N E E G P ++LS
Sbjct: 5806 DSTVNQKEGKLKIGTNRALHLQEEKTEMHKARTANLEK-ERGRMDTSSSAHP----HLLS 5860
Query: 1161 -PVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLK 1208
++ K Q+ +++ N+ I+++ + +L N K Q Q+L +
Sbjct: 5861 LKAEESQMKTQVITHRENSRLIMQK---QKKELEASNAKQSIQLQKLFQ 5906
>gi|239744870 PREDICTED: hypothetical protein LOC643677 [Homo sapiens]
Length = 6929
Score = 32.0 bits (71), Expect = 8.5
Identities = 52/229 (22%), Positives = 95/229 (41%), Gaps = 25/229 (10%)
Query: 988 RISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPV 1047
R + +LS + + G+ +ET L ++P I + + GRK+ +
Sbjct: 5695 RTNTILSKFPLQSGKQKTPSETDVDKKTTAHLSLQMLPGIHMDMTEIDPAKGGRKQALLI 5754
Query: 1048 QLDDEGGRTFLRVLIHLIMHDYPP----LLSGALQLLFKHFSQRAEVLQAFKQVQLLVSN 1103
+EG FL + +PP SG L+ KH + A +Q +L + N
Sbjct: 5755 SEQEEGVLEFLPKSL------FPPWTFQFQSGDLE--EKHQTD-ANTNINLEQKKLEMDN 5805
Query: 1104 QDVDNYKQIKADLD---QLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILS 1160
N K+ K + L L EK+E+ +++N E E G P ++LS
Sbjct: 5806 DSTVNQKEGKLKIGTNRALHLQEEKTEMHKARTANLEK-ERGRMDTSSSAHP----HLLS 5860
Query: 1161 -PVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLK 1208
++ K Q+ +++ N+ I+++ + +L N K Q Q+L +
Sbjct: 5861 LKAEESQMKTQVITHRENSRLIMQK---QKKELEASNAKQSIQLQKLFQ 5906
>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 32.0 bits (71), Expect = 8.5
Identities = 29/152 (19%), Positives = 69/152 (45%), Gaps = 18/152 (11%)
Query: 1095 KQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNY-----ENGEIGESQVKGG 1149
++ LL + +Y + + +LD L+ T+E+SE ++ + E E+ E+++K
Sbjct: 724 EEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNA 783
Query: 1150 EEPIEESNILSPVQDGTKKPQIDSNKSN--------NYRIVKEILIRLSKLCVQNKKCRN 1201
E E ++D KK K++ + V+ I + L +L ++ +
Sbjct: 784 EAERERE-----LKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQ 838
Query: 1202 QHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNE 1233
Q + + + + ++ ++++ KN E +N+
Sbjct: 839 QLEAVNEAIKSYESQIEVMAAEVAKNKESVNK 870
>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 32.0 bits (71), Expect = 8.5
Identities = 29/152 (19%), Positives = 69/152 (45%), Gaps = 18/152 (11%)
Query: 1095 KQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNY-----ENGEIGESQVKGG 1149
++ LL + +Y + + +LD L+ T+E+SE ++ + E E+ E+++K
Sbjct: 724 EEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNA 783
Query: 1150 EEPIEESNILSPVQDGTKKPQIDSNKSN--------NYRIVKEILIRLSKLCVQNKKCRN 1201
E E ++D KK K++ + V+ I + L +L ++ +
Sbjct: 784 EAERERE-----LKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQ 838
Query: 1202 QHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNE 1233
Q + + + + ++ ++++ KN E +N+
Sbjct: 839 QLEAVNEAIKSYESQIEVMAAEVAKNKESVNK 870
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,522,556
Number of Sequences: 37866
Number of extensions: 4291779
Number of successful extensions: 12340
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 12123
Number of HSP's gapped (non-prelim): 134
length of query: 2701
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2581
effective length of database: 13,703,598
effective search space: 35368986438
effective search space used: 35368986438
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.