Guide to the Human Genome
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Name: NPC1L1 Sequence: fasta or formatted (1332aa) NCBI GI: 156231353
Description:

Niemann-Pick C1-like protein 1 isoform 2

Referenced in:

Stomach, Small Intestine, and Colon
Hedgehog and Related Pathways
Additional Membrane Functions

Other entries for this name:
alt prot [1359aa] Niemann-Pick C1-like protein 1 isoform 1
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             9.4        125           3
 C cysteine            3.1         41           3
 D aspartate           3.8         50           2
 E glutamate           3.9         52           2
 F phenylalanine       5.6         75           3
 G glycine             6.5         86           2
 H histidine           1.5         20           1
 I isoleucine          4.6         61           3
 K lysine              2.8         37           2
 L leucine            14.0        186           4
 M methionine          2.3         30           1
 N asparagine          4.3         57           2
 P proline             5.3         71           3
 Q glutamine           4.1         54           1
 R arginine            4.1         54           2
 S serine              8.4        112           2
 T threonine           5.2         69           2
 V valine              6.8         91           2
 W tryptophan          1.3         17           1
 Y tyrosine            3.3         44           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   Niemann-Pick C1-like protein 1 isoform 2 
NPC1L1                0.994   Niemann-Pick C1-like protein 1 isoform 1 
NPC1                  0.333   Niemann-Pick disease, type C1 precursor 
PTCH1                 0.038   patched isoform S 
PTCH1                 0.038   patched isoform S 
PTCH1                 0.038   patched isoform S 
PTCH1                 0.038   patched isoform S 
PTCH1                 0.038   patched isoform L' 
PTCH1                 0.038   patched isoform M 
PTCH1                 0.038   patched isoform L 
PTCH2                 0.032   patched 2 
C6orf138              0.030   hypothetical protein LOC442213 
PTCHD3                0.028   patched domain containing 3 
PTCHD1                0.025   patched domain containing 1 
SCAP                  0.019   SREBF chaperone protein 
PTCHD2                0.009   patched domain containing 2 
DISP2                 0.009   dispatched B 
DISP1                 0.006   dispatched A 
TMCO6                 0.003   transmembrane and coiled-coil domains 6 
LOC730429             0.003   PREDICTED: similar to ubiquitin protein ligase E3 c...
LOC730429             0.003   PREDICTED: similar to ubiquitin protein ligase E3 c...
C2                    0.003   complement component 2 isoform 1 preproprotein [Homo...
UBR5                  0.003   ubiquitin protein ligase E3 component n-recognin 5 [...
CSF3                  0.003   colony stimulating factor 3 isoform c 
CSF3                  0.003   colony stimulating factor 3 isoform b precursor [Hom...
APOB                  0.002   apolipoprotein B precursor 
MYO9B                 0.002   myosin IXB isoform 2 
MYO9B                 0.002   myosin IXB isoform 1 
CSGALNACT1            0.002   chondroitin sulfate N-acetylgalactosaminyltransfera...
CSGALNACT1            0.002   chondroitin sulfate N-acetylgalactosaminyltransfera...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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