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Search of human proteins with 154091312
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154091312 transient receptor potential cation channel,
subfamily M, member 3 isoform b [Homo sapiens]
(1566 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154091312 transient receptor potential cation channel, subfam... 3150 0.0
gi|154091316 transient receptor potential cation channel, subfam... 3123 0.0
gi|154091320 transient receptor potential cation channel, subfam... 3112 0.0
gi|154091314 transient receptor potential cation channel, subfam... 3112 0.0
gi|154091308 transient receptor potential cation channel, subfam... 3098 0.0
gi|154091318 transient receptor potential cation channel, subfam... 3085 0.0
gi|154091310 transient receptor potential cation channel, subfam... 3071 0.0
gi|148612863 transient receptor potential cation channel, subfam... 1360 0.0
gi|18921093 transient receptor potential cation channel, subfami... 1260 0.0
gi|94538366 transient receptor potential cation channel, subfami... 1225 0.0
gi|4507689 transient receptor potential cation channel, subfamil... 524 e-148
gi|21314671 transient receptor potential cation channel, subfami... 473 e-133
gi|11225266 transient receptor potential cation channel, subfami... 465 e-130
gi|45935368 transient receptor potential cation channel, subfami... 464 e-130
gi|55953096 transient receptor potential cation channel, subfami... 450 e-126
gi|109689695 transient receptor potential cation channel, subfam... 274 6e-73
gi|209863032 transient receptor potential cation channel, subfam... 80 1e-14
gi|209863030 transient receptor potential cation channel, subfam... 80 1e-14
gi|209863026 transient receptor potential cation channel, subfam... 80 1e-14
gi|7706747 transient receptor potential cation channel, subfamil... 80 1e-14
gi|209863024 transient receptor potential cation channel, subfam... 78 6e-14
gi|6912736 transient receptor potential cation channel, subfamil... 71 7e-12
gi|209863028 transient receptor potential cation channel, subfam... 62 3e-09
gi|9966865 transient receptor potential cation channel, subfamil... 57 1e-07
gi|194733735 transient receptor potential cation channel, subfam... 57 2e-07
gi|4507687 transient receptor potential cation channel, subfamil... 57 2e-07
gi|5730102 transient receptor potential cation channel, subfamil... 54 9e-07
gi|21314682 transient receptor potential cation channel, subfami... 53 3e-06
gi|17505200 transient receptor potential cation channel, subfami... 50 1e-05
gi|4507685 transient receptor potential cation channel, subfamil... 47 2e-04
>gi|154091312 transient receptor potential cation channel, subfamily
M, member 3 isoform b [Homo sapiens]
Length = 1566
Score = 3150 bits (8166), Expect = 0.0
Identities = 1566/1566 (100%), Positives = 1566/1566 (100%)
Query: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
Query: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL
Sbjct: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
Query: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS
Sbjct: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
Query: 301 APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH 360
APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH
Sbjct: 301 APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH 360
Query: 361 RFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
RFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV
Sbjct: 361 RFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
Query: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD 480
IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD
Sbjct: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD 480
Query: 481 IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 540
IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS
Sbjct: 481 IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 540
Query: 541 ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 600
ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA
Sbjct: 541 ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 600
Query: 601 AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ 660
AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ
Sbjct: 601 AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ 660
Query: 661 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK 720
AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK
Sbjct: 661 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK 720
Query: 721 IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI 780
IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI
Sbjct: 721 IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI 780
Query: 781 LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY 840
LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY
Sbjct: 781 LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY 840
Query: 841 IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA 900
IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA
Sbjct: 841 IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA 900
Query: 901 KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN 960
KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN
Sbjct: 901 KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN 960
Query: 961 ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL 1020
ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL
Sbjct: 961 ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL 1020
Query: 1021 CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT 1080
CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT
Sbjct: 1021 CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT 1080
Query: 1081 SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI 1140
SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI
Sbjct: 1081 SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI 1140
Query: 1141 RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS 1200
RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS
Sbjct: 1141 RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS 1200
Query: 1201 VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID 1260
VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID
Sbjct: 1201 VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID 1260
Query: 1261 IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF 1320
IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF
Sbjct: 1261 IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF 1320
Query: 1321 EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH 1380
EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH
Sbjct: 1321 EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH 1380
Query: 1381 SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC 1440
SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC
Sbjct: 1381 SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC 1440
Query: 1441 CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE 1500
CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE
Sbjct: 1441 CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE 1500
Query: 1501 EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS 1560
EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS
Sbjct: 1501 EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS 1560
Query: 1561 FESKHN 1566
FESKHN
Sbjct: 1561 FESKHN 1566
>gi|154091316 transient receptor potential cation channel, subfamily
M, member 3 isoform e [Homo sapiens]
Length = 1556
Score = 3123 bits (8096), Expect = 0.0
Identities = 1556/1566 (99%), Positives = 1556/1566 (99%), Gaps = 10/1566 (0%)
Query: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
Query: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL
Sbjct: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
Query: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS
Sbjct: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
Query: 301 APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH 360
APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH
Sbjct: 301 APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH 360
Query: 361 RFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
RFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV
Sbjct: 361 RFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
Query: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD 480
IEYLMGGAYRCNYTRKRFRTLYHNLFGPKR DDIPLRRGRKTTKKREEEVD
Sbjct: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKR----------DDIPLRRGRKTTKKREEEVD 470
Query: 481 IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 540
IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS
Sbjct: 471 IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 530
Query: 541 ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 600
ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA
Sbjct: 531 ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 590
Query: 601 AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ 660
AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ
Sbjct: 591 AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ 650
Query: 661 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK 720
AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK
Sbjct: 651 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK 710
Query: 721 IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI 780
IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI
Sbjct: 711 IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI 770
Query: 781 LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY 840
LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY
Sbjct: 771 LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY 830
Query: 841 IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA 900
IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA
Sbjct: 831 IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA 890
Query: 901 KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN 960
KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN
Sbjct: 891 KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN 950
Query: 961 ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL 1020
ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL
Sbjct: 951 ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL 1010
Query: 1021 CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT 1080
CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT
Sbjct: 1011 CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT 1070
Query: 1081 SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI 1140
SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI
Sbjct: 1071 SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI 1130
Query: 1141 RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS 1200
RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS
Sbjct: 1131 RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS 1190
Query: 1201 VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID 1260
VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID
Sbjct: 1191 VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID 1250
Query: 1261 IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF 1320
IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF
Sbjct: 1251 IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF 1310
Query: 1321 EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH 1380
EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH
Sbjct: 1311 EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH 1370
Query: 1381 SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC 1440
SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC
Sbjct: 1371 SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC 1430
Query: 1441 CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE 1500
CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE
Sbjct: 1431 CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE 1490
Query: 1501 EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS 1560
EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS
Sbjct: 1491 EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS 1550
Query: 1561 FESKHN 1566
FESKHN
Sbjct: 1551 FESKHN 1556
>gi|154091320 transient receptor potential cation channel, subfamily
M, member 3 isoform a [Homo sapiens]
Length = 1554
Score = 3112 bits (8068), Expect = 0.0
Identities = 1554/1566 (99%), Positives = 1554/1566 (99%), Gaps = 12/1566 (0%)
Query: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
Query: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL
Sbjct: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
Query: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS
Sbjct: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
Query: 301 APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH 360
APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH
Sbjct: 301 APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH 360
Query: 361 RFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
RFLTISRLEELYNTRHGPSNTLYHLVRDVKK GNLPPDYRISLIDIGLV
Sbjct: 361 RFLTISRLEELYNTRHGPSNTLYHLVRDVKK------------GNLPPDYRISLIDIGLV 408
Query: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD 480
IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD
Sbjct: 409 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD 468
Query: 481 IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 540
IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS
Sbjct: 469 IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 528
Query: 541 ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 600
ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA
Sbjct: 529 ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 588
Query: 601 AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ 660
AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ
Sbjct: 589 AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ 648
Query: 661 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK 720
AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK
Sbjct: 649 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK 708
Query: 721 IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI 780
IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI
Sbjct: 709 IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI 768
Query: 781 LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY 840
LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY
Sbjct: 769 LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY 828
Query: 841 IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA 900
IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA
Sbjct: 829 IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA 888
Query: 901 KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN 960
KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN
Sbjct: 889 KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN 948
Query: 961 ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL 1020
ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL
Sbjct: 949 ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL 1008
Query: 1021 CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT 1080
CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT
Sbjct: 1009 CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT 1068
Query: 1081 SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI 1140
SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI
Sbjct: 1069 SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI 1128
Query: 1141 RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS 1200
RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS
Sbjct: 1129 RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS 1188
Query: 1201 VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID 1260
VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID
Sbjct: 1189 VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID 1248
Query: 1261 IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF 1320
IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF
Sbjct: 1249 IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF 1308
Query: 1321 EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH 1380
EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH
Sbjct: 1309 EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH 1368
Query: 1381 SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC 1440
SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC
Sbjct: 1369 SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC 1428
Query: 1441 CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE 1500
CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE
Sbjct: 1429 CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE 1488
Query: 1501 EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS 1560
EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS
Sbjct: 1489 EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS 1548
Query: 1561 FESKHN 1566
FESKHN
Sbjct: 1549 FESKHN 1554
>gi|154091314 transient receptor potential cation channel, subfamily
M, member 3 isoform k [Homo sapiens]
Length = 1707
Score = 3112 bits (8068), Expect = 0.0
Identities = 1554/1566 (99%), Positives = 1554/1566 (99%), Gaps = 12/1566 (0%)
Query: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT
Sbjct: 154 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 213
Query: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ
Sbjct: 214 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 273
Query: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV
Sbjct: 274 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 333
Query: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL
Sbjct: 334 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 393
Query: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS
Sbjct: 394 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 453
Query: 301 APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH 360
APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH
Sbjct: 454 APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH 513
Query: 361 RFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
RFLTISRLEELYNTRHGPSNTLYHLVRDVKK GNLPPDYRISLIDIGLV
Sbjct: 514 RFLTISRLEELYNTRHGPSNTLYHLVRDVKK------------GNLPPDYRISLIDIGLV 561
Query: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD 480
IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD
Sbjct: 562 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD 621
Query: 481 IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 540
IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS
Sbjct: 622 IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 681
Query: 541 ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 600
ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA
Sbjct: 682 ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 741
Query: 601 AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ 660
AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ
Sbjct: 742 AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ 801
Query: 661 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK 720
AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK
Sbjct: 802 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK 861
Query: 721 IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI 780
IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI
Sbjct: 862 IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI 921
Query: 781 LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY 840
LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY
Sbjct: 922 LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY 981
Query: 841 IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA 900
IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA
Sbjct: 982 IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA 1041
Query: 901 KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN 960
KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN
Sbjct: 1042 KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN 1101
Query: 961 ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL 1020
ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL
Sbjct: 1102 ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL 1161
Query: 1021 CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT 1080
CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT
Sbjct: 1162 CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT 1221
Query: 1081 SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI 1140
SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI
Sbjct: 1222 SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI 1281
Query: 1141 RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS 1200
RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS
Sbjct: 1282 RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS 1341
Query: 1201 VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID 1260
VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID
Sbjct: 1342 VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID 1401
Query: 1261 IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF 1320
IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF
Sbjct: 1402 IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF 1461
Query: 1321 EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH 1380
EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH
Sbjct: 1462 EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH 1521
Query: 1381 SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC 1440
SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC
Sbjct: 1522 SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC 1581
Query: 1441 CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE 1500
CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE
Sbjct: 1582 CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE 1641
Query: 1501 EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS 1560
EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS
Sbjct: 1642 EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS 1701
Query: 1561 FESKHN 1566
FESKHN
Sbjct: 1702 FESKHN 1707
>gi|154091308 transient receptor potential cation channel, subfamily
M, member 3 isoform f [Homo sapiens]
Length = 1579
Score = 3098 bits (8032), Expect = 0.0
Identities = 1554/1591 (97%), Positives = 1554/1591 (97%), Gaps = 37/1591 (2%)
Query: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR-------- 172
TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLD 180
Query: 173 -----------------IGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA 215
IGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA
Sbjct: 181 SRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA 240
Query: 216 SDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVF 275
SDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVF
Sbjct: 241 SDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVF 300
Query: 276 RMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQ 335
RMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQ
Sbjct: 301 RMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQ 360
Query: 336 AMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYP 395
AMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKK
Sbjct: 361 AMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKK---- 416
Query: 396 GFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALK 455
GNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALK
Sbjct: 417 --------GNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALK 468
Query: 456 LLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFW 515
LLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFW
Sbjct: 469 LLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFW 528
Query: 516 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 575
QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE
Sbjct: 529 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 588
Query: 576 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 635
QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI
Sbjct: 589 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 648
Query: 636 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRN 695
LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRN
Sbjct: 649 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRN 708
Query: 696 NGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME 755
NGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME
Sbjct: 709 NGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME 768
Query: 756 RWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGM 815
RWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGM
Sbjct: 769 RWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGM 828
Query: 816 ILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML 875
ILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML
Sbjct: 829 ILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML 888
Query: 876 VVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKI 935
VVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKI
Sbjct: 889 VVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKI 948
Query: 936 IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM 995
IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM
Sbjct: 949 IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM 1008
Query: 996 TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE 1055
TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE
Sbjct: 1009 TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE 1068
Query: 1056 QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL 1115
QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL
Sbjct: 1069 QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL 1128
Query: 1116 EDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESID 1175
EDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESID
Sbjct: 1129 EDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESID 1188
Query: 1176 PAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKE 1235
PAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKE
Sbjct: 1189 PAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKE 1248
Query: 1236 PKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVP 1295
PKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVP
Sbjct: 1249 PKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVP 1308
Query: 1296 STAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTI 1355
STAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTI
Sbjct: 1309 STAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTI 1368
Query: 1356 ERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCV 1415
ERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCV
Sbjct: 1369 ERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCV 1428
Query: 1416 NAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGRRATIAISSQEG 1475
NAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGRRATIAISSQEG
Sbjct: 1429 NAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGRRATIAISSQEG 1488
Query: 1476 DNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRS 1535
DNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRS
Sbjct: 1489 DNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRS 1548
Query: 1536 KSSKPEGRGDSLSMRRLSRTSAFQSFESKHN 1566
KSSKPEGRGDSLSMRRLSRTSAFQSFESKHN
Sbjct: 1549 KSSKPEGRGDSLSMRRLSRTSAFQSFESKHN 1579
>gi|154091318 transient receptor potential cation channel, subfamily
M, member 3 isoform d [Homo sapiens]
Length = 1544
Score = 3085 bits (7998), Expect = 0.0
Identities = 1544/1566 (98%), Positives = 1544/1566 (98%), Gaps = 22/1566 (1%)
Query: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
Query: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL
Sbjct: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
Query: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS
Sbjct: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
Query: 301 APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH 360
APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH
Sbjct: 301 APDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMH 360
Query: 361 RFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
RFLTISRLEELYNTRHGPSNTLYHLVRDVKK GNLPPDYRISLIDIGLV
Sbjct: 361 RFLTISRLEELYNTRHGPSNTLYHLVRDVKK------------GNLPPDYRISLIDIGLV 408
Query: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVD 480
IEYLMGGAYRCNYTRKRFRTLYHNLFGPKR DDIPLRRGRKTTKKREEEVD
Sbjct: 409 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKR----------DDIPLRRGRKTTKKREEEVD 458
Query: 481 IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 540
IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS
Sbjct: 459 IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 518
Query: 541 ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 600
ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA
Sbjct: 519 ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 578
Query: 601 AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ 660
AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ
Sbjct: 579 AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQ 638
Query: 661 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK 720
AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK
Sbjct: 639 AQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRK 698
Query: 721 IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI 780
IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI
Sbjct: 699 IYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREI 758
Query: 781 LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY 840
LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY
Sbjct: 759 LMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWY 818
Query: 841 IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA 900
IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA
Sbjct: 819 IRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLA 878
Query: 901 KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN 960
KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN
Sbjct: 879 KNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVAN 938
Query: 961 ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL 1020
ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL
Sbjct: 939 ILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHL 998
Query: 1021 CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT 1080
CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT
Sbjct: 999 CCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVT 1058
Query: 1081 SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI 1140
SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI
Sbjct: 1059 SERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKI 1118
Query: 1141 RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS 1200
RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS
Sbjct: 1119 RSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYS 1178
Query: 1201 VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID 1260
VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID
Sbjct: 1179 VNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCID 1238
Query: 1261 IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF 1320
IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF
Sbjct: 1239 IYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDF 1298
Query: 1321 EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH 1380
EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH
Sbjct: 1299 EDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSH 1358
Query: 1381 SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC 1440
SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC
Sbjct: 1359 SFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTC 1418
Query: 1441 CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE 1500
CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE
Sbjct: 1419 CHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAE 1478
Query: 1501 EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS 1560
EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS
Sbjct: 1479 EPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQS 1538
Query: 1561 FESKHN 1566
FESKHN
Sbjct: 1539 FESKHN 1544
>gi|154091310 transient receptor potential cation channel, subfamily
M, member 3 isoform g [Homo sapiens]
Length = 1569
Score = 3071 bits (7962), Expect = 0.0
Identities = 1544/1591 (97%), Positives = 1544/1591 (97%), Gaps = 47/1591 (2%)
Query: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR-------- 172
TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLD 180
Query: 173 -----------------IGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA 215
IGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA
Sbjct: 181 SRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA 240
Query: 216 SDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVF 275
SDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVF
Sbjct: 241 SDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVF 300
Query: 276 RMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQ 335
RMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQ
Sbjct: 301 RMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQ 360
Query: 336 AMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYP 395
AMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKK
Sbjct: 361 AMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKK---- 416
Query: 396 GFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALK 455
GNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKR
Sbjct: 417 --------GNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKR----- 463
Query: 456 LLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFW 515
DDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFW
Sbjct: 464 -----DDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFW 518
Query: 516 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 575
QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE
Sbjct: 519 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 578
Query: 576 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 635
QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI
Sbjct: 579 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 638
Query: 636 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRN 695
LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRN
Sbjct: 639 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRN 698
Query: 696 NGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME 755
NGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME
Sbjct: 699 NGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME 758
Query: 756 RWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGM 815
RWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGM
Sbjct: 759 RWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGM 818
Query: 816 ILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML 875
ILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML
Sbjct: 819 ILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML 878
Query: 876 VVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKI 935
VVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKI
Sbjct: 879 VVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKI 938
Query: 936 IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM 995
IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM
Sbjct: 939 IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM 998
Query: 996 TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE 1055
TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE
Sbjct: 999 TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE 1058
Query: 1056 QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL 1115
QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL
Sbjct: 1059 QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL 1118
Query: 1116 EDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESID 1175
EDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESID
Sbjct: 1119 EDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESID 1178
Query: 1176 PAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKE 1235
PAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKE
Sbjct: 1179 PAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKE 1238
Query: 1236 PKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVP 1295
PKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVP
Sbjct: 1239 PKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVP 1298
Query: 1296 STAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTI 1355
STAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTI
Sbjct: 1299 STAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTI 1358
Query: 1356 ERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCV 1415
ERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCV
Sbjct: 1359 ERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCV 1418
Query: 1416 NAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGRRATIAISSQEG 1475
NAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGRRATIAISSQEG
Sbjct: 1419 NAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGRRATIAISSQEG 1478
Query: 1476 DNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRS 1535
DNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRS
Sbjct: 1479 DNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRS 1538
Query: 1536 KSSKPEGRGDSLSMRRLSRTSAFQSFESKHN 1566
KSSKPEGRGDSLSMRRLSRTSAFQSFESKHN
Sbjct: 1539 KSSKPEGRGDSLSMRRLSRTSAFQSFESKHN 1569
>gi|148612863 transient receptor potential cation channel, subfamily
M, member 7 [Homo sapiens]
Length = 1865
Score = 1360 bits (3521), Expect = 0.0
Identities = 686/1199 (57%), Positives = 892/1199 (74%), Gaps = 74/1199 (6%)
Query: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
Query: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
GAWI TGGVNTGV +HVGDALK+HAS+S KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
Query: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
+ NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
Query: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241
LI EGGPNVI VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++ ++
Sbjct: 288 LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDII 347
Query: 242 VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301
TI+KTF + + +A HLF LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA
Sbjct: 348 STIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASA 407
Query: 302 PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361
DQL L LAW+RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+
Sbjct: 408 FDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHK 467
Query: 362 FLTISRLEELYNTRHGPSNT-LYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
FLTI RLEELYNT+ GP+N L+HLVRDVK+ GNLPP Y+I+LIDIGLV
Sbjct: 468 FLTIPRLEELYNTKQGPTNPMLFHLVRDVKQ------------GNLPPGYKITLIDIGLV 515
Query: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFG-------------PKRPKALKLLGMEDDI---- 463
IEYLMGG YRC YTRKRFR +Y++L G P+ K+ + G D
Sbjct: 516 IEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKM 575
Query: 464 ----------PLRRGRKTT-----KKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQ 508
P R T KKR ++ +D+DDPE FP+P +EL++WA LMKRQ
Sbjct: 576 RHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQ 635
Query: 509 KMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLD 568
MA F WQHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+EL S DFGQLAVELL+
Sbjct: 636 VMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLE 695
Query: 569 QSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK 628
QS++QDE +AMKLLTYELKNWSN+TCL+LAV+++ R F+AHTC+QMLL+DMWMGRL MRK
Sbjct: 696 QSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRK 755
Query: 629 NSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP--EKPTKEKEEEDM 686
NS KVIL IL+PP+IL LE+K K +M ++ Q+Q+ H + E + T+E E
Sbjct: 756 NSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVF 815
Query: 687 ELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLF 746
+ +L N G K+E E+Q K + +P+ RK Y FY+APIVKFWF TLAY+G+LML+
Sbjct: 816 KEVRILDSNEG-----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLY 870
Query: 747 NYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLI 806
++VLV+ME+ PS QEWIVI+YIFT IEK+REI MSE GK+ QK+KVW +Y+N++D I
Sbjct: 871 TFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTI 930
Query: 807 AILLFSVGMILRL---------QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYV 857
AI+ F +G LR D GR+IYC+NII+WY+RLLD VN+ GPYV
Sbjct: 931 AIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYV 990
Query: 858 MMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFA 917
MMIGKM+ +M Y V+IM +VL+SFGV R+AIL+P+E PSW LAK+I + PYWMI+GEV+A
Sbjct: 991 MMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYA 1050
Query: 918 DQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFE 977
+ID D I Q+ C G W+ P + A YL V I++VNLLIA FNN + +
Sbjct: 1051 YEID------VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQ 1102
Query: 978 VKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYG 1037
VK+ISN VWK+QRY IM +HE+PVLPPPLII SH+ +F +C R +K D+ G
Sbjct: 1103 VKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKK-----DKTSDG 1157
Query: 1038 LKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNER 1097
KLF+T+++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRVT ERVE M ++++EV +R
Sbjct: 1158 PKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDR 1217
Query: 1098 EHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVR 1156
+ +K SLQ++D ++ L+DL L+ LT + +E++K+ + + + + + ++ +
Sbjct: 1218 VNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQ 1276
>gi|18921093 transient receptor potential cation channel, subfamily M,
member 6 [Homo sapiens]
Length = 2022
Score = 1260 bits (3261), Expect = 0.0
Identities = 639/1175 (54%), Positives = 847/1175 (72%), Gaps = 67/1175 (5%)
Query: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Y+R S+DTK D LLHLM KEW++ELPKL+ISVHGG+QNF + K K++F +GL+KAA TT
Sbjct: 111 YIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETT 170
Query: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
GAWI T G+NTGV +HVGDALK H+S S KI T+GI PWG++ENQ DLIG+DVV YQT
Sbjct: 171 GAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQT 230
Query: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
+ NP+SKLT LNSMHSHFIL+D+GT GKYG E+KLRR LEK++SLQKI+ R QGVPVV
Sbjct: 231 LDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVG 290
Query: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241
L+VEGGPNVI V E ++D PV VVC+G+GRA+D+LAF HK+ + G++ ++++++
Sbjct: 291 LVVEGGPNVILSVWETVKDKDPV--VVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEII 348
Query: 242 VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301
IQ TF ++ Q++HLF ILMECM ++ IT+F SE QD+DLAILTALLKG N SA
Sbjct: 349 CMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSA 408
Query: 302 PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361
+QL+LA+AW+RVDIA+ I IY Q W +LEQAM DALV+DRVDFVKLLIE GV++HR
Sbjct: 409 SEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHR 468
Query: 362 FLTISRLEELYNTRHGPSNTL-YHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
FLTI RLEELYNT+ GP+NTL +HLV+DVK+ L YRI+LIDIGLV
Sbjct: 469 FLTIPRLEELYNTKQGPTNTLLHHLVQDVKQH------------TLLSGYRITLIDIGLV 516
Query: 421 IEYLMGGAYRCNYTRKRFRTLYHNLF----------GPKRPKALKLLGM----------- 459
+EYL+G AYR NYTRK FR LY+NL+ G + A L
Sbjct: 517 VEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKF 576
Query: 460 -EDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHG 518
E I L + RK K +E+ V DDPE F +P+++L+VWAVLMKRQKMA+FFWQHG
Sbjct: 577 KEKSIVLHKSRK--KSKEQNVS---DDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHG 631
Query: 519 EEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLA 578
EEA KA++AC L +AMAHEA E+ MVDD S+EL + S+ FGQLA++LL++++KQ+E++A
Sbjct: 632 EEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMA 691
Query: 579 MKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGI 638
M LLTYEL+NWSN+TCL+LAV+ R F++HTC+QMLLTDMWMGRL+MRKNS LK+I+ I
Sbjct: 692 MTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISI 751
Query: 639 LLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEK---EEEDMELTAMLGRN 695
+LPP+IL+LEFK+K +M ++ Q+Q+ +++ +KE +E D+E R
Sbjct: 752 ILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE------RG 805
Query: 696 NGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME 755
+ E + ++S H+ +P RK+YEFY+APIVKFWFYT+AY+ +LMLF Y VLV+M+
Sbjct: 806 HDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQ 865
Query: 756 RWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGM 815
PS QEW+V YIFT IE +REI +SEPGK QKVKVW+ EYWN+T+ +AI LFS G
Sbjct: 866 PQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGF 925
Query: 816 ILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML 875
+LR D PF + GR+IYC++II+W+ RLLD F VN++ GPYV MI KM +M Y VIIM
Sbjct: 926 VLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMA 985
Query: 876 VVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKI 935
+VL+SFGVAR+AIL P E PSW LA++I + PYWMIYGEV+A +ID Q
Sbjct: 986 IVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ--------- 1036
Query: 936 IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM 995
P C G+++ P + A YL V I++VNLLIA FNN + +++SISN +WK+ RY+ IM
Sbjct: 1037 ---PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIM 1093
Query: 996 TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE 1055
T+HE+P LPPPLI+ SH+ ++ + LCC H D +E D GLKL+++ ++LKK+HDFEE
Sbjct: 1094 TYHEKPWLPPPLILLSHVGLLLRRLCCHRAPH--DQEEGDVGLKLYLSKEDLKKLHDFEE 1151
Query: 1056 QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL 1115
QC+E+YF EK + N S +ERIRVTSERV M +L+E+NE+ +K SL ++D ++ L
Sbjct: 1152 QCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHL 1211
Query: 1116 EDLIGRMATALERLTGLERAESNK--IRSRTSSDC 1148
+DL L+ L+ ++ + ++ + R S C
Sbjct: 1212 QDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTC 1246
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 1225 bits (3169), Expect = 0.0
Identities = 684/1216 (56%), Positives = 829/1216 (68%), Gaps = 114/1216 (9%)
Query: 330 VGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV 389
V +LEQAMLDALVLDRVDFVKLLIENGV+M FLTI RLEELYNTR GP NTL+ LVRDV
Sbjct: 458 VNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDV 517
Query: 390 KKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPK 449
KK NLPPDY ISLIDIGLV+EYLMGGAYRCNYTRK FRTLY+NLFGPK
Sbjct: 518 KK------------SNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPK 565
Query: 450 RPKALKLLGMEDDIPLRRGRKTTKKR-EEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQ 508
RPKALKLLGMEDD P +G+K KK+ EEE+DID+DDP ++ F +PFHELMVWAVLMKRQ
Sbjct: 566 RPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQ 625
Query: 509 KMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLD 568
KMA+F WQ GEE+MAKALVACKL KAMAHE+SE+D+VDDISQ+L++NS+DFGQLA+ELLD
Sbjct: 626 KMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLD 685
Query: 569 QSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK 628
QSYK DEQ+AMKLLTYELKNWSN+TCL+LAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK
Sbjct: 686 QSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK 745
Query: 629 NSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMEL 688
N GLKVI+GILLPP+IL LEF+ DD Y + KE E+ KEKEEE+ +
Sbjct: 746 NPGLKVIMGILLPPTILFLEFRTYDDFSYQTS--------KENEDG----KEKEEENTDA 793
Query: 689 TAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNY 748
A G SRK DEE K R IP+G KI EFYNAPIVKFWFYT++Y+GYL+LFNY
Sbjct: 794 NADAG------SRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNY 847
Query: 749 IVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAI 808
++LV+M+ WPS QEWIVISYI +L +EK+REILMSEPGKL QK+KVWLQEYWN+TDL+AI
Sbjct: 848 VILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAI 907
Query: 809 LLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMM 868
F +G ILRLQ+QP+ GRVIYCV+II+WYIR+LDIFGVNKYLGPYVMMIGKMMIDM+
Sbjct: 908 STFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDML 967
Query: 869 YFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID------- 921
YFV+IMLVVLMSFGVARQAIL P E+PSWKLA+NIFYMPYWMIYGEVFADQID
Sbjct: 968 YFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEIN 1027
Query: 922 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 981
PPCG+N E+GK +LPPC GAW+ PA+MACYLLVANILLVNLLIAVFNNTFFEVKSI
Sbjct: 1028 PPCGENLYDEEGK--RLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSI 1085
Query: 982 SNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWR-KHESDPDERDYGLKL 1040
SNQVWKFQRYQLIMTFH+RPVLPPP+II SH+ +I L R R K E D +ERD GLKL
Sbjct: 1086 SNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKL 1145
Query: 1041 FITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHS 1100
F++D+ELK++H+FEEQC++E+FREK+D SS+DERIRVTSERVENMSMRLEE+NERE
Sbjct: 1146 FLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETF 1205
Query: 1101 MKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSF 1160
MK SLQTVD+RLAQLE+L RM ALE L G++R++ + RSR SS+C +A Y++RQSS
Sbjct: 1206 MKTSLQTVDLRLAQLEELSNRMVNALENLAGIDRSDLIQARSRASSEC-EATYLLRQSSI 1264
Query: 1161 NSQEGNT-----FKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESI 1215
NS +G + F +E + E+T TSP R ++ SF KD +
Sbjct: 1265 NSADGYSLYRYHFNGEELL---FEDTSLSTSPGTGVRKKTCSFRIKEEKD-----VKTHL 1316
Query: 1216 FKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDP 1275
E SLH + + + A PD H +D
Sbjct: 1317 VPECQNSLHLSLGTSTSA---------------TPDGS----------------HLAVDD 1345
Query: 1276 LDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDY 1335
L N+ E S P + T + + S S++ D+ +S +
Sbjct: 1346 LKNA-------EESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNT 1398
Query: 1336 THLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFG 1395
E N E + + +E +K +RY + +KS SF++S R
Sbjct: 1399 QLTVETTN---IEGTISYPLEETKITRYFPDE--TINACKTMKSRSFVYSRGRKLVGGVN 1453
Query: 1396 VPVKTAEYTSITD---CIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHP 1452
V EY+SITD + +C + P + E + + +
Sbjct: 1454 QDV---EYSSITDQQLTTEWQCQVQKITRSHSTDIP-----YIVSEAAVQAEHKEQFADM 1505
Query: 1453 SSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKS 1512
+ EA R ++++ + + E LS K ++ + + + + H R
Sbjct: 1506 QDEHHVAEAIPRIPRLSLTITDRNGMENLLS-----VKPDQTLGFPSLRSKSLHGHPRNV 1560
Query: 1513 FSISDKLDRQRNTASL 1528
SI KLDR + +S+
Sbjct: 1561 KSIQGKLDRSGHASSV 1576
Score = 572 bits (1474), Expect = e-162
Identities = 274/334 (82%), Positives = 309/334 (92%), Gaps = 1/334 (0%)
Query: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
MY+RVS+DTKPD LLHLM K+WQLELPKLLISVHGGLQNFE+QPKLKQVFGKGLIKAAMT
Sbjct: 71 MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMT 130
Query: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
TGAWIFTGGV+TGVI HVGDALKDH+SKSRG++C IGIAPWGIVEN+EDL+G+DV R YQ
Sbjct: 131 TGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQ 190
Query: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
TMSNP+SKL+VLN+ H+HFILADNGT GKYGAEVKLRR LEKHISLQKINTR+GQGVP+V
Sbjct: 191 TMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQGVPLV 250
Query: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
L+VEGGPNV+SIVLEYL++ PP+PVV+CDGSGRASDIL+F HKY EEGG+INESLR+QL
Sbjct: 251 GLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINESLREQL 310
Query: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
LVTIQKTF Y + Q+ LF I+MECMKKKEL+TVFRMGSEG QDI++AILTALLKG N S
Sbjct: 311 LVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNVS 370
Query: 301 APDQLSLALAWNRVDIARSQIFIYGQQW-PVGSL 333
APDQLSLALAWNRVDIARSQIF++G W P+GSL
Sbjct: 371 APDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL 404
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 524 bits (1350), Expect = e-148
Identities = 374/1166 (32%), Positives = 595/1166 (51%), Gaps = 139/1166 (11%)
Query: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
YVRVS DT ++ HLMT+ W L++P LLISV GG +NF ++P+LK +F +GL+K A TT
Sbjct: 142 YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTT 201
Query: 62 GAWIFTGGVNTGVIRHVGDALKDHASKS---RGKICTIGIAPWGIVENQEDLIGRDVVRP 118
GAWI TGG +TGV++ VG+A++D + S G++ TIG+A WG V +E LI P
Sbjct: 202 GAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFP 261
Query: 119 --YQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQ-KINTRIGQ 175
Y + LT L+S HSHFIL D+GT G+YG E+ LR +LEK IS Q K +
Sbjct: 262 AEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAI 321
Query: 176 GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINES 235
+P+V +++EGGP + + T P VV +GSGR +D++A I+
Sbjct: 322 KIPIVCVVLEGGPGTLHTIDN--ATTNGTPCVVVEGSGRVADVIAQVANLPVSDITIS-L 378
Query: 236 LRDQLLVTIQKTF-TYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALL 294
++ +L V Q+ F T+T ++ + + +++++L+TVFR G +G QD+D+AIL ALL
Sbjct: 379 IQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALL 438
Query: 295 KGANASA-------PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVD 347
K + + QL LA+AWNRVDIARS+IF+ QW L M AL+ ++ +
Sbjct: 439 KASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPE 498
Query: 348 FVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV--KKREYPGFGWIYFKGN 405
FVKL +ENGV + F+T L LY PS + ++ V + E P
Sbjct: 499 FVKLFLENGVQLKEFVTWDTLLYLYENLD-PSCLFHSKLQKVLVEDPERPACA------- 550
Query: 406 LPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPL 465
P R+ + + V+ L+G + Y R R L K L + G+
Sbjct: 551 -PAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVK-LNVQGVSL---- 604
Query: 466 RRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKA 525
R K+ V +D P +L++WA++ R+++A W ++ +A A
Sbjct: 605 ---RSLYKRSSGHVTFTMD---------PIRDLLIWAIVQNRRELAGIIWAQSQDCIAAA 652
Query: 526 LVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYE 585
L K+ K ++ E + D S+E+ + ++ A+ + + Y++DE+ A KLLT
Sbjct: 653 LACSKILKELSKEEEDTDS----SEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRV 708
Query: 586 LKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL-KVILGILLPPSI 644
+ W TCLQLA+ AK F++H Q LT +W G+L + ++GL +V L +L P +
Sbjct: 709 SEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV--DNGLWRVTLCMLAFPLL 766
Query: 645 LSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKD 704
LT ++ S R+K
Sbjct: 767 -------------------------------------------LTGLI------SFREKR 777
Query: 705 EEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWI 764
++V + + F+ AP+V F L+Y +L LF Y+++V + PS E
Sbjct: 778 LQDVGTP------AARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECA 831
Query: 765 VISYIFTLGIEKMREILMSEPGK--LLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQ 822
+ ++F+L E+MR+ L +P + L++K ++ ++WN D+ AILLF G+ RL
Sbjct: 832 IYLWLFSLVCEEMRQ-LFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPA 890
Query: 823 PFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFG 882
GRVI ++ I + +RL+ IF ++K LGP ++++ +MM D+ +F+ ++ V ++SFG
Sbjct: 891 TLYP-GRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFG 949
Query: 883 VARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV--FADQID---PPCGQNETR------- 930
VA+QAIL NE L + Y Y I+G++ + D ++ C N T
Sbjct: 950 VAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCP 1009
Query: 931 EDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQR 990
E Q P W+ ++ YLL NILL+NLLIA+FN TF +V+ ++Q+WKFQR
Sbjct: 1010 ESDATQQRPAFPE--WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQR 1067
Query: 991 YQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKV 1050
+ LI +H RP PPP I+ SH+ + + + + P +R LK + +E +
Sbjct: 1068 HDLIEEYHGRPAAPPPFILLSHLQLFIKRVVLK------TPAKRHKQLKNKLEKNEEAAL 1121
Query: 1051 HDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLE-EVNEREHSMKASLQTVD 1109
+E E Y + + + +++I S +V+ M L+ + +R SM+
Sbjct: 1122 LSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQ------ 1175
Query: 1110 IRLAQLEDLIGRMATALERLTGLERA 1135
RLA LE+ + + A AL + RA
Sbjct: 1176 -RLASLEEQVAQTARALHWIVRTLRA 1200
>gi|21314671 transient receptor potential cation channel, subfamily M,
member 4 [Homo sapiens]
Length = 1214
Score = 473 bits (1216), Expect = e-133
Identities = 350/1172 (29%), Positives = 590/1172 (50%), Gaps = 111/1172 (9%)
Query: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
++R+S T P + L+T+ W P L++SV GG LQ L+ + +GL++AA +T
Sbjct: 90 FLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQST 149
Query: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRG--KICTIGIAPWGIVENQEDLIGRDVVRP- 118
GAWI TGG++TG+ RHVG A++DH S G K+ +G+APWG+V N++ LI P
Sbjct: 150 GAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPA 209
Query: 119 -YQTMSNPMSKLTV-LNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR-IGQ 175
Y+ +P + L+ +S F L D+GT G G E + R +LE +IS QK G
Sbjct: 210 RYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGI 269
Query: 176 GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYS---EEGGLI 232
+PV+ L+++G +++ + + +P ++ GSG A+D LA + + GG
Sbjct: 270 DIPVLLLLIDGDEKMLTRIENATQ--AQLPCLLVAGSGGAADCLAETLEDTLAPGSGGAR 327
Query: 233 NESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTA 292
RD++ + F + + + L + M +KEL+TV+ +G ++ + +L A
Sbjct: 328 QGEARDRI-----RRF-FPKGDLEVLQAQVERIMTRKELLTVYS-SEDGSEEFETIVLKA 380
Query: 293 LLKGANASAP----DQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDF 348
L+K +S D+L LA+AWNRVDIA+S++F QW LE +++DAL+ DR +F
Sbjct: 381 LVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEF 440
Query: 349 VKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNL-- 406
V+LLI +G+S+ FLT RL +LY+ PSN+L + D G KG
Sbjct: 441 VRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIRNLLDQASHS-AGTKAPALKGGAAE 497
Query: 407 --PPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIP 464
PPD +G V+ L+G + P+ P G D P
Sbjct: 498 LRPPD-------VGHVLRMLLG-----------------KMCAPRYPSG----GAWDPHP 529
Query: 465 LRRGRKTTKKREEEVDIDLD-DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMA 523
+ ++ ++ L D + P+ +L++WA+L+ R +MA++FW+ G A++
Sbjct: 530 GQGFGESMYLLSDKATSPLSLDAGLGQAPWS--DLLLWALLLNRAQMAMYFWEMGSNAVS 587
Query: 524 KALVACKLCKAMAH---EASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMK 580
AL AC L + MA +A E D++ + F + V+L + Y+ E A +
Sbjct: 588 SALGACLLLRVMARLEPDAEEAARRKDLAFK-------FEGMGVDLFGECYRSSEVRAAR 640
Query: 581 LLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILL 640
LL W +ATCLQLA+ A R F A Q LLT W G + ++L
Sbjct: 641 LLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWA-LVLAFFC 699
Query: 641 PPSILS--LEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGE 698
PP I + + F+ ++ P + + E P E+ + + GR
Sbjct: 700 PPLIYTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCC 759
Query: 699 SSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP 758
R + R+ + F+ AP+ F ++Y+ +L+LF+ ++LV + P
Sbjct: 760 GGRCGGRRCL----------RRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAP 809
Query: 759 -STQEWIVISYIFTLGIEKMREILMSEPGKLL------------QKVKVWLQEYWNVTDL 805
+ E ++ + FTL E++R+ L G L Q+++++L + WN DL
Sbjct: 810 PGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDL 869
Query: 806 IAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMI 865
+A+ F +G+ RL + GR + C++ + + +RLL IF VNK LGP ++++ KMM
Sbjct: 870 VALTCFLLGVGCRLTPGLYHL-GRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMK 928
Query: 866 DMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCG 925
D+ +F+ + V L+++GVA + +L P + + + +FY PY I+G++ + +D
Sbjct: 929 DVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALM 988
Query: 926 Q--NETREDGKIIQLPPCKTGA-------WIVPAIMACYLLVANILLVNLLIAVFNNTFF 976
+ N + E G P + G W+V ++ +LLVANILLVNLLIA+F+ TF
Sbjct: 989 EHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFG 1048
Query: 977 EVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDY 1036
+V+ S+ WK QRY+LI FH RP L PP I+ SH+ ++ + LC R R + ++
Sbjct: 1049 KVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEH 1108
Query: 1037 GLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNE 1096
+++++ + +K+ +E E + + S+ ER++ TS++V+ +L + E
Sbjct: 1109 -FRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIRE 1167
Query: 1097 REHSMKASLQTVDIRLAQLEDLIGRMATALER 1128
E +K ++ + Q ++G +A AL R
Sbjct: 1168 YEQRLK----VLEREVQQCSRVLGWVAEALSR 1195
>gi|11225266 transient receptor potential cation channel, subfamily M,
member 5 [Homo sapiens]
Length = 1165
Score = 465 bits (1197), Expect = e-130
Identities = 345/1143 (30%), Positives = 563/1143 (49%), Gaps = 121/1143 (10%)
Query: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
+VRV P +L L+ EW L P L++S+ G Q F ++ L+ V KGL+KAA +T
Sbjct: 40 FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99
Query: 62 GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111
GAWI T + G+ RHVG A++DH+ + ++ ++ +G+A G V E QED
Sbjct: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158
Query: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171
V + L L+S SHFIL + G GK +LR +LEKHIS Q
Sbjct: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211
Query: 172 RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKY 225
R G G +PV+ L+V G PN + + + P ++V GSG +D+LA
Sbjct: 212 RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA----- 264
Query: 226 SEEGGLINESLRDQLLV--TIQKTFTYTRTQAQHLFI--------ILMECMKKKELITVF 275
L+N+ LLV +K F + ++H +L + L+TV+
Sbjct: 265 ----ALVNQP---HLLVPKVAEKQFK-EKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVY 316
Query: 276 RMGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVDIARSQIFIYGQQWP 329
EG +++D IL AL+K + + D+L LA+AW+RVDIA+S+IF +W
Sbjct: 317 DFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWK 376
Query: 330 VGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV 389
LE+ M+DALV ++ +FV+L ++NG + FLT RL+ELY + S L R
Sbjct: 377 SCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQ 436
Query: 390 KKREYPGFGWIYFKGNLPP--DYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFG 447
++ G + PP SL ++ V++ + A R Y R G
Sbjct: 437 EEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEKG 496
Query: 448 P-KRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMK 506
P KRP K L +DL+ N P+ +L +WAVL
Sbjct: 497 PAKRPTGQKWL-----------------------LDLNQKSEN----PWRDLFLWAVLQN 529
Query: 507 RQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVEL 566
R +MA +FW G+E +A AL ACK+ K M+H +E + + + +LA++L
Sbjct: 530 RHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREA------KYERLALDL 583
Query: 567 LDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRM 626
+ Y E A LL + WS TCL LA A + F AH Q LT +W G M
Sbjct: 584 FSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGD--M 641
Query: 627 RKNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEED 685
+ + +LG L P+++ ++ P + ++ LQ+ ++ + EK +
Sbjct: 642 AAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSLDTEKSPLYGLQSR 699
Query: 686 MELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLML 745
+E R G+ R + L + +F+ AP+ F + Y +L L
Sbjct: 700 VEELVEAPRAQGDRGP-----------RAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFL 748
Query: 746 FNYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKLLQKVKVWLQEYWN 801
F Y++LV + PS E + ++FTL +E++R+ E L++K +++ + WN
Sbjct: 749 FTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWN 808
Query: 802 VTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIG 861
D++AI LF VG+ R+ F + GR + ++ + + +RL+ IF ++K LGP ++++
Sbjct: 809 KCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVE 867
Query: 862 KMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID 921
+MM D+ +F+ + V L+++GV QA+L P++ + + + Y PY I+G++ D+ID
Sbjct: 868 RMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEID 927
Query: 922 PPCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVK 979
N + + P C + W+V ++ +LLV N+LL+NLLIA+F+ TF V+
Sbjct: 928 E-ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQ 986
Query: 980 SISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLK 1039
++ WKFQRY LI+ +HERP L PP I+ SH+++ + + + +H+ + ERD
Sbjct: 987 GNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERD---- 1042
Query: 1040 LFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREH 1099
+ D +KV +E E + + + R S E +R T+ RV+ ++ L + E+E
Sbjct: 1043 --LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEK 1100
Query: 1100 SMK 1102
+K
Sbjct: 1101 RIK 1103
>gi|45935368 transient receptor potential cation channel, subfamily
M, member 3 isoform h [Homo sapiens]
Length = 230
Score = 464 bits (1194), Expect = e-130
Identities = 230/230 (100%), Positives = 230/230 (100%)
Query: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
Query: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGG 230
ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGG
Sbjct: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGG 230
>gi|55953096 transient receptor potential cation channel, subfamily
M, member 3 isoform c [Homo sapiens]
Length = 255
Score = 450 bits (1158), Expect = e-126
Identities = 230/255 (90%), Positives = 230/255 (90%), Gaps = 25/255 (9%)
Query: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR-------- 172
TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLD 180
Query: 173 -----------------IGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA 215
IGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA
Sbjct: 181 SRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA 240
Query: 216 SDILAFGHKYSEEGG 230
SDILAFGHKYSEEGG
Sbjct: 241 SDILAFGHKYSEEGG 255
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 274 bits (700), Expect = 6e-73
Identities = 192/658 (29%), Positives = 322/658 (48%), Gaps = 84/658 (12%)
Query: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Y+R+S DT ++L L+T+ W L+ P L+ISV GG +NF L+P+++++F + LI A +
Sbjct: 117 YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSK 175
Query: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
GAWI TGG + G+++++G+ ++D+ + S I IGIA WG+V N++ LI Y
Sbjct: 176 GAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGY 235
Query: 120 QTMSNPMSKLT-----VLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKI-NTRI 173
M T +L++ H+H +L DNG G E KLR QLEK+IS + I ++
Sbjct: 236 FLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNY 295
Query: 174 GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLIN 233
G +P+V GG + + +++ +P VV +GSG+ +D++A E L +
Sbjct: 296 GGKIPIVCFAQGGGKETLKAINTSIKNK--IPCVVVEGSGQIADVIA--SLVEVEDALTS 351
Query: 234 ESLRDQLLVTIQKTFTYTRTQAQHLFII-LMECMKKKELITVFRMGSEGHQDIDLAILTA 292
+++++L+ + +T + + +I L E ++ L+TV +M G + + AI A
Sbjct: 352 SAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYA 411
Query: 293 LLKGANASAPD------QLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRV 346
L K + S D QL L L WN++D+A +IF ++W L++ M AL+ DR
Sbjct: 412 LYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRP 471
Query: 347 DFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNL 406
FV+L +ENG+++ +FLT L EL++ +TL + + K Y
Sbjct: 472 KFVRLFLENGLNLRKFLTHDVLTELFSNHF---STLVYRNLQIAKNSYN----------- 517
Query: 407 PPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLR 466
D L + + +R + + ED R
Sbjct: 518 ---------DALLTFVWKLVANFRRGFRK------------------------ED----R 540
Query: 467 RGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKAL 526
GR E ++++ P H P L +WA+L +++++ W+ AL
Sbjct: 541 NGRD-----EMDIELHDVSPITRH---PLQALFIWAILQNKKELSKVIWEQTRGCTLAAL 592
Query: 527 VACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYEL 586
A KL K +A ++ + + S+EL + ++ AVEL + Y DE LA +LL Y
Sbjct: 593 GASKLLKTLAKVKNDINAAGE-SEEL---ANEYETRAVELFTECYSSDEDLAEQLLVYSC 648
Query: 587 KNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSI 644
+ W + CL+LAV A + FIA Q L+ W G + R K+IL + + P +
Sbjct: 649 EAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEI-SRDTKNWKIILCLFIIPLV 705
Score = 172 bits (435), Expect = 3e-42
Identities = 109/370 (29%), Positives = 193/370 (52%), Gaps = 32/370 (8%)
Query: 724 FYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMS 783
F+ +P V F + + YI +L+LF Y++L+ P E ++ S +F L +++R+ ++
Sbjct: 730 FFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVN 789
Query: 784 EPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRS--DGRVIYCVNIIYWYI 841
+ + WNV D + + F G++ RL S GRVI+C++ I + +
Sbjct: 790 GVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTL 841
Query: 842 RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 901
RL+ IF V++ LGP ++M+ +M+ID+ +F+ + V +++FGVARQ IL NE+ + +
Sbjct: 842 RLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFR 901
Query: 902 NIFYMPYWMIYGEVFADQID------PPCGQNETREDGKIIQLPP---CKTGAWIVPAIM 952
++ Y PY ++G+V +D +D C ++L + WI ++
Sbjct: 902 SVIYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV 960
Query: 953 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSH 1012
Y+L NILLVNLL+A+F T V+ ++QVWKFQRY L+ + R +P P I+F++
Sbjct: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
Query: 1013 MTMIFQ---HLCCRWRKHES------DPDERDYGLKLFITDDELKKVHDFEEQCIEEY-- 1061
M+ + CC+ + ES + D + + ++ L K++ EE
Sbjct: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
Query: 1062 -FREKDDRFN 1070
FR+ D + N
Sbjct: 1081 RFRQLDTKLN 1090
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 80.5 bits (197), Expect = 1e-14
Identities = 76/377 (20%), Positives = 164/377 (43%), Gaps = 71/377 (18%)
Query: 724 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 776
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 185 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 244
Query: 777 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 826
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 245 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 297
Query: 827 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 881
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 298 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 357
Query: 882 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 926
+ F EE K I +W I+G + + Q
Sbjct: 358 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 416
Query: 927 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 986
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ W
Sbjct: 417 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 462
Query: 987 KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGL 1038
KF R +L M++ E V+P P ++ + I+ HLC + + + + +G
Sbjct: 463 KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPE----SFGT 518
Query: 1039 KLFITDDELKKVHDFEE 1055
D L++ H ++E
Sbjct: 519 IGRRAADNLRRHHQYQE 535
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 80.5 bits (197), Expect = 1e-14
Identities = 76/377 (20%), Positives = 164/377 (43%), Gaps = 71/377 (18%)
Query: 724 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 776
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 777 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 826
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
Query: 827 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 881
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
Query: 882 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 926
+ F EE K I +W I+G + + Q
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
Query: 927 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 986
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ W
Sbjct: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
Query: 987 KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGL 1038
KF R +L M++ E V+P P ++ + I+ HLC + + + + +G
Sbjct: 636 KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPE----SFGT 691
Query: 1039 KLFITDDELKKVHDFEE 1055
D L++ H ++E
Sbjct: 692 IGRRAADNLRRHHQYQE 708
Score = 32.0 bits (71), Expect = 4.8
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 15/109 (13%)
Query: 546 DDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTY-------ELKNWSNATCLQLA 598
++ E SR Q A +LLDQ+ + +L + +L Y E ++ ++ L+LA
Sbjct: 235 NEFKSEYEELSRQCKQFAKDLLDQT-RSSRELEI-ILNYRDDNSLIEEQSGNDLARLKLA 292
Query: 599 VAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 641
+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 293 IKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 80.5 bits (197), Expect = 1e-14
Identities = 76/377 (20%), Positives = 164/377 (43%), Gaps = 71/377 (18%)
Query: 724 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 776
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 777 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 826
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
Query: 827 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 881
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
Query: 882 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 926
+ F EE K I +W I+G + + Q
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
Query: 927 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 986
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ W
Sbjct: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
Query: 987 KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGL 1038
KF R +L M++ E V+P P ++ + I+ HLC + + + + +G
Sbjct: 636 KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPE----SFGT 691
Query: 1039 KLFITDDELKKVHDFEE 1055
D L++ H ++E
Sbjct: 692 IGRRAADNLRRHHQYQE 708
Score = 32.0 bits (71), Expect = 4.8
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 15/109 (13%)
Query: 546 DDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTY-------ELKNWSNATCLQLA 598
++ E SR Q A +LLDQ+ + +L + +L Y E ++ ++ L+LA
Sbjct: 235 NEFKSEYEELSRQCKQFAKDLLDQT-RSSRELEI-ILNYRDDNSLIEEQSGNDLARLKLA 292
Query: 599 VAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 641
+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 293 IKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
>gi|7706747 transient receptor potential cation channel, subfamily C,
member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 80.5 bits (197), Expect = 1e-14
Identities = 76/377 (20%), Positives = 164/377 (43%), Gaps = 71/377 (18%)
Query: 724 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 776
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 777 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 826
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
Query: 827 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 881
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
Query: 882 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 926
+ F EE K I +W I+G + + Q
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
Query: 927 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 986
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ W
Sbjct: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
Query: 987 KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGL 1038
KF R +L M++ E V+P P ++ + I+ HLC + + + + +G
Sbjct: 636 KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPE----SFGT 691
Query: 1039 KLFITDDELKKVHDFEE 1055
D L++ H ++E
Sbjct: 692 IGRRAADNLRRHHQYQE 708
Score = 32.0 bits (71), Expect = 4.8
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 15/109 (13%)
Query: 546 DDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTY-------ELKNWSNATCLQLA 598
++ E SR Q A +LLDQ+ + +L + +L Y E ++ ++ L+LA
Sbjct: 235 NEFKSEYEELSRQCKQFAKDLLDQT-RSSRELEI-ILNYRDDNSLIEEQSGNDLARLKLA 292
Query: 599 VAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 641
+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 293 IKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 78.2 bits (191), Expect = 6e-14
Identities = 71/343 (20%), Positives = 150/343 (43%), Gaps = 67/343 (19%)
Query: 724 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 776
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 777 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 826
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
Query: 827 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 881
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
Query: 882 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 926
+ F EE K I +W I+G + + Q
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
Query: 927 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 986
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ W
Sbjct: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
Query: 987 KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLC 1021
KF R +L M++ E V+P P ++ + I+ HLC
Sbjct: 636 KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
Score = 32.0 bits (71), Expect = 4.8
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 15/109 (13%)
Query: 546 DDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTY-------ELKNWSNATCLQLA 598
++ E SR Q A +LLDQ+ + +L + +L Y E ++ ++ L+LA
Sbjct: 235 NEFKSEYEELSRQCKQFAKDLLDQT-RSSRELEI-ILNYRDDNSLIEEQSGNDLARLKLA 292
Query: 599 VAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 641
+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 293 IKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
>gi|6912736 transient receptor potential cation channel, subfamily C,
member 5 [Homo sapiens]
Length = 973
Score = 71.2 bits (173), Expect = 7e-12
Identities = 76/360 (21%), Positives = 154/360 (42%), Gaps = 77/360 (21%)
Query: 724 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 776
F P +KF +T +Y+ +L + +IV + P+ EW+++ ++ +
Sbjct: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
Query: 777 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGR------- 829
++E M + G ++ ++WN+ D L+ + L++ + R
Sbjct: 419 IKE--MWDGG-----FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
Query: 830 --------VIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 881
++ ++ I +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
Query: 882 GVARQAILF---------PNEEPSWKLAK--NIF-------YMPYWMIYG--EVFADQID 921
+ F PN + K N F +W ++G ++ +
Sbjct: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591
Query: 922 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 981
++E E ++ + Y +++ ++L+N+LIA+ NN++ +
Sbjct: 592 ---ARHEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADH 634
Query: 982 SNQVWKFQRYQLIMT-FHERPVLPPPLII------FSHMTMIFQHLCCRWRKHESDPDER 1034
++ WKF R +L M+ F E LPPP I F ++ F + C R DPD R
Sbjct: 635 ADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKR----DPDGR 690
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 62.4 bits (150), Expect = 3e-09
Identities = 60/310 (19%), Positives = 135/310 (43%), Gaps = 60/310 (19%)
Query: 724 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 776
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 777 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 826
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
Query: 827 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 881
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
Query: 882 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 926
+ F EE K I +W I+G + + Q
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
Query: 927 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF-FEVKSISNQV 985
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ +
Sbjct: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNL 635
Query: 986 WKFQRYQLIM 995
+ +YQ +M
Sbjct: 636 RRHHQYQEVM 645
Score = 32.0 bits (71), Expect = 4.8
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 15/109 (13%)
Query: 546 DDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTY-------ELKNWSNATCLQLA 598
++ E SR Q A +LLDQ+ + +L + +L Y E ++ ++ L+LA
Sbjct: 235 NEFKSEYEELSRQCKQFAKDLLDQT-RSSRELEI-ILNYRDDNSLIEEQSGNDLARLKLA 292
Query: 599 VAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 641
+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 293 IKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
>gi|9966865 transient receptor potential cation channel, subfamily C,
member 7 [Homo sapiens]
Length = 862
Score = 57.0 bits (136), Expect = 1e-07
Identities = 46/198 (23%), Positives = 95/198 (47%), Gaps = 28/198 (14%)
Query: 820 QDQPFRSDGRVI----YCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML 875
+D+ + SD ++I Y + ++ + R+ I N+ GP + +G+ + D+ F++I +
Sbjct: 528 RDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFI 587
Query: 876 VVLMSFGVARQAILF----PNEEPSWKLAKNIFYMPYWMIYG--EVFADQIDPPCGQNET 929
+V ++F + + P++ + F +W I+G EV + +
Sbjct: 588 MVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVL--------- 638
Query: 930 REDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQ 989
+ D K I+ I + Y + ++L+N+LIA+ NN++ E++ ++ WKF
Sbjct: 639 KYDHKFIEN--------IGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFA 690
Query: 990 RYQLIMT-FHERPVLPPP 1006
R +L ++ F E LP P
Sbjct: 691 RAKLWLSYFDEGRTLPAP 708
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 56.6 bits (135), Expect = 2e-07
Identities = 48/226 (21%), Positives = 102/226 (45%), Gaps = 25/226 (11%)
Query: 791 KVKVWLQEYWNVTDLIAILLF-SVGMILRLQDQPFRSDGRVI----YCVNIIYWYIRLLD 845
K + ++ Y +DL + L + +D+ SD ++I Y + ++ + R+
Sbjct: 569 KAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAY 628
Query: 846 IFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI----LFPNEEPSWKLAK 901
I N+ GP + +G+ + D+ F+++ ++V +F + + L ++ +
Sbjct: 629 ILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 688
Query: 902 NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANI 961
F +W I+G + + D K I+ I + Y + +
Sbjct: 689 ESFKTLFWSIFGLSEVTSV-------VLKYDHKFIEN--------IGYVLYGIYNVTMVV 733
Query: 962 LLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVLPPP 1006
+L+N+LIA+ N+++ E++ S+ WKF R +L ++ F + LPPP
Sbjct: 734 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPP 779
Score = 32.7 bits (73), Expect = 2.8
Identities = 19/103 (18%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Query: 715 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME-RWPSTQEWIVISYIFTLG 773
I LGR + + + ++ + IG +L++Y + K+ + + +E + G
Sbjct: 641 ISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG 700
Query: 774 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 816
+ ++ +++ K ++ + L +NVT ++ +L + MI
Sbjct: 701 LSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMI 743
>gi|4507687 transient receptor potential cation channel, subfamily C,
member 3 isoform b [Homo sapiens]
Length = 848
Score = 56.6 bits (135), Expect = 2e-07
Identities = 48/226 (21%), Positives = 102/226 (45%), Gaps = 25/226 (11%)
Query: 791 KVKVWLQEYWNVTDLIAILLF-SVGMILRLQDQPFRSDGRVI----YCVNIIYWYIRLLD 845
K + ++ Y +DL + L + +D+ SD ++I Y + ++ + R+
Sbjct: 496 KAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAY 555
Query: 846 IFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAI----LFPNEEPSWKLAK 901
I N+ GP + +G+ + D+ F+++ ++V +F + + L ++ +
Sbjct: 556 ILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVE 615
Query: 902 NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANI 961
F +W I+G + + D K I+ I + Y + +
Sbjct: 616 ESFKTLFWSIFGLSEVTSV-------VLKYDHKFIEN--------IGYVLYGIYNVTMVV 660
Query: 962 LLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVLPPP 1006
+L+N+LIA+ N+++ E++ S+ WKF R +L ++ F + LPPP
Sbjct: 661 VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPP 706
Score = 32.7 bits (73), Expect = 2.8
Identities = 19/103 (18%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Query: 715 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME-RWPSTQEWIVISYIFTLG 773
I LGR + + + ++ + IG +L++Y + K+ + + +E + G
Sbjct: 568 ISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG 627
Query: 774 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 816
+ ++ +++ K ++ + L +NVT ++ +L + MI
Sbjct: 628 LSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMI 670
>gi|5730102 transient receptor potential cation channel, subfamily C,
member 6 [Homo sapiens]
Length = 931
Score = 54.3 bits (129), Expect = 9e-07
Identities = 70/349 (20%), Positives = 133/349 (38%), Gaps = 89/349 (25%)
Query: 759 STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILR 818
S E ++IS++ + + +EI P K +L E WN+ D + +F+ I R
Sbjct: 492 SWMEMLIISWVIGMIWAECKEIWTQGP-------KEYLFELWNMLDFGMLAIFAASFIAR 544
Query: 819 LQ-------------------------------------------DQPFRSDGRVIYCVN 835
D S+G +Y +
Sbjct: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEG--LYAIA 602
Query: 836 IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGV-----------A 884
++ + R+ I N+ GP + +G+ + D+ F++I ++V ++F + A
Sbjct: 603 VVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGA 662
Query: 885 RQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTG 944
+Q F E S+K +W I+G + G ++
Sbjct: 663 KQNEAFTTVEESFKTL-------FWAIFGLSEVKSVVINYNHKFIENIGYVLY------- 708
Query: 945 AWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVL 1003
Y + I+L+N+LIA+ N++F E++ ++ WKF R +L + F E L
Sbjct: 709 --------GVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTL 760
Query: 1004 PPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHD 1052
P P + +F +L + +K S+ + K F D E+ K+++
Sbjct: 761 PVPFNLVPSPKSLF-YLLLKLKKWISELFQGH--KKGFQEDAEMNKINE 806
Score = 36.6 bits (83), Expect = 0.20
Identities = 21/103 (20%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 715 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKM-ERWPSTQEWIVISYIFTLG 773
I LGR + + + ++ + IG L++Y + K E + + +E + G
Sbjct: 625 ISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFG 684
Query: 774 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 816
+ +++ ++++ K ++ + L +NVT +I +L + MI
Sbjct: 685 LSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMI 727
>gi|21314682 transient receptor potential cation channel, subfamily
V, member 6 [Homo sapiens]
Length = 725
Score = 52.8 bits (125), Expect = 3e-06
Identities = 41/138 (29%), Positives = 68/138 (49%), Gaps = 17/138 (12%)
Query: 853 LGPYVMMIGKMMI-DMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMI 911
LGP+ +MI KM+ D+M F +M VV++ F A I+F E+P +L Y
Sbjct: 475 LGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFY-IIFQTEDPE-ELGHFYDYPMALFS 532
Query: 912 YGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVF 971
E+F ID P N + LP ++ A + ++A +L++NLLIA+
Sbjct: 533 TFELFLTIIDGPANYN--------VDLP------FMYSITYAAFAIIATLLMLNLLIAMM 578
Query: 972 NNTFFEVKSISNQVWKFQ 989
+T + V +++W+ Q
Sbjct: 579 GDTHWRVAHERDELWRAQ 596
>gi|17505200 transient receptor potential cation channel, subfamily
V, member 5 [Homo sapiens]
Length = 729
Score = 50.4 bits (119), Expect = 1e-05
Identities = 38/138 (27%), Positives = 68/138 (49%), Gaps = 17/138 (12%)
Query: 853 LGPYVMMIGKMMI-DMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMI 911
LGP+ +MI KM+ D+M F +M VV++ F A I+F E+P+ L + Y
Sbjct: 475 LGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFY-IIFQTEDPT-SLGQFYDYPMALFT 532
Query: 912 YGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVF 971
E+F ID P + + LP ++ + + ++A +L++NL IA+
Sbjct: 533 TFELFLTVIDAPANYD--------VDLP------FMFSIVNFAFAIIATLLMLNLFIAMM 578
Query: 972 NNTFFEVKSISNQVWKFQ 989
+T + V +++W+ Q
Sbjct: 579 GDTHWRVAQERDELWRAQ 596
>gi|4507685 transient receptor potential cation channel, subfamily C,
member 1 [Homo sapiens]
Length = 759
Score = 46.6 bits (109), Expect = 2e-04
Identities = 68/322 (21%), Positives = 131/322 (40%), Gaps = 56/322 (17%)
Query: 726 NAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIV--ISYIFTLGIEKMREILMS 783
+ P +KF + +Y +L+L N LV E +T + I Y+ L I M + S
Sbjct: 347 HTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGM---IWS 403
Query: 784 EPGKL-LQKVKVWLQEYWNVTDLIAILLFSVGMILRL------QDQPFRSD--------- 827
+ +L + ++ +L+E N + L+ L++ D R D
Sbjct: 404 DIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLV 463
Query: 828 GRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQA 887
++ + Y+RL ++ + LGP + +G+M+ D F+ + L+VL SF +
Sbjct: 464 AEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQ 523
Query: 888 IL---FPNEEPSWKLAKNIF----------------YMPYWMIYGEVFADQIDPPCGQNE 928
+ + ++E K IF + +W I+ E
Sbjct: 524 LYDKGYTSKEQ--KDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGE 581
Query: 929 TREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKF 988
+ +++ I+ Y +V I+L LL+A+ + +F + + ++ WKF
Sbjct: 582 ELQ-------------SFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKF 628
Query: 989 QRYQLIMT-FHERPVLPPPLII 1009
R +L ++ F ++ LPPP I
Sbjct: 629 ARAKLWLSYFDDKCTLPPPFNI 650
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,804,489
Number of Sequences: 37866
Number of extensions: 2773659
Number of successful extensions: 13631
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 12870
Number of HSP's gapped (non-prelim): 685
length of query: 1566
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1450
effective length of database: 13,855,062
effective search space: 20089839900
effective search space used: 20089839900
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.