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Search of human proteins with 148612863
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148612863 transient receptor potential cation channel,
subfamily M, member 7 [Homo sapiens]
(1865 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148612863 transient receptor potential cation channel, subfam... 3779 0.0
gi|18921093 transient receptor potential cation channel, subfami... 1499 0.0
gi|154091314 transient receptor potential cation channel, subfam... 1462 0.0
gi|154091320 transient receptor potential cation channel, subfam... 1369 0.0
gi|154091318 transient receptor potential cation channel, subfam... 1368 0.0
gi|154091312 transient receptor potential cation channel, subfam... 1360 0.0
gi|154091316 transient receptor potential cation channel, subfam... 1359 0.0
gi|154091308 transient receptor potential cation channel, subfam... 1355 0.0
gi|154091310 transient receptor potential cation channel, subfam... 1354 0.0
gi|94538366 transient receptor potential cation channel, subfami... 1169 0.0
gi|4507689 transient receptor potential cation channel, subfamil... 506 e-142
gi|11225266 transient receptor potential cation channel, subfami... 418 e-116
gi|45935368 transient receptor potential cation channel, subfami... 362 2e-99
gi|55953096 transient receptor potential cation channel, subfami... 348 3e-95
gi|21314671 transient receptor potential cation channel, subfami... 255 3e-67
gi|109689695 transient receptor potential cation channel, subfam... 240 1e-62
gi|209863032 transient receptor potential cation channel, subfam... 84 1e-15
gi|209863030 transient receptor potential cation channel, subfam... 84 1e-15
gi|209863026 transient receptor potential cation channel, subfam... 84 1e-15
gi|7706747 transient receptor potential cation channel, subfamil... 84 1e-15
gi|209863024 transient receptor potential cation channel, subfam... 84 2e-15
gi|6912736 transient receptor potential cation channel, subfamil... 75 6e-13
gi|148596992 heart alpha-kinase [Homo sapiens] 70 2e-11
gi|209863028 transient receptor potential cation channel, subfam... 68 1e-10
gi|9558749 elongation factor-2 kinase [Homo sapiens] 63 3e-09
gi|5730102 transient receptor potential cation channel, subfamil... 62 5e-09
gi|9966865 transient receptor potential cation channel, subfamil... 61 1e-08
gi|194733735 transient receptor potential cation channel, subfam... 60 2e-08
gi|4507687 transient receptor potential cation channel, subfamil... 60 2e-08
gi|156151443 alpha-kinase 1 [Homo sapiens] 54 1e-06
>gi|148612863 transient receptor potential cation channel, subfamily
M, member 7 [Homo sapiens]
Length = 1865
Score = 3779 bits (9801), Expect = 0.0
Identities = 1865/1865 (100%), Positives = 1865/1865 (100%)
Query: 1 MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAM 60
MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAM
Sbjct: 1 MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAM 60
Query: 61 KYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVI 120
KYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVI
Sbjct: 61 KYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVI 120
Query: 121 LQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGV 180
LQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGV
Sbjct: 121 LQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGV 180
Query: 181 AKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNN 240
AKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNN
Sbjct: 181 AKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNN 240
Query: 241 LHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTV 300
LHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTV
Sbjct: 241 LHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTV 300
Query: 301 LEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNE 360
LEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNE
Sbjct: 301 LEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNE 360
Query: 361 ALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRV 420
ALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRV
Sbjct: 361 ALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRV 420
Query: 421 DIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNT 480
DIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNT
Sbjct: 421 DIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNT 480
Query: 481 KQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540
KQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL
Sbjct: 481 KQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL 540
Query: 541 GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK 600
GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK
Sbjct: 541 GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK 600
Query: 601 KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660
KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR
Sbjct: 601 KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR 660
Query: 661 SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720
SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST
Sbjct: 661 SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST 720
Query: 721 CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA 780
CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA
Sbjct: 721 CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA 780
Query: 781 EMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP 840
EMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP
Sbjct: 781 EMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP 840
Query: 841 ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK 900
ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK
Sbjct: 841 ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK 900
Query: 901 VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA 960
VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA
Sbjct: 901 VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA 960
Query: 961 GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA 1020
GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA
Sbjct: 961 GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA 1020
Query: 1021 ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY 1080
ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY
Sbjct: 1021 ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY 1080
Query: 1081 LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS 1140
LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS
Sbjct: 1081 LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS 1140
Query: 1141 LFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVT 1200
LFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVT
Sbjct: 1141 LFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVT 1200
Query: 1201 FERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKV 1260
FERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKV
Sbjct: 1201 FERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKV 1260
Query: 1261 HNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMK 1320
HNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMK
Sbjct: 1261 HNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMK 1320
Query: 1321 DDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNK 1380
DDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNK
Sbjct: 1321 DDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNK 1380
Query: 1381 NQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAF 1440
NQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAF
Sbjct: 1381 NQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAF 1440
Query: 1441 VGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKIS 1500
VGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKIS
Sbjct: 1441 VGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKIS 1500
Query: 1501 RRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVER 1560
RRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVER
Sbjct: 1501 RRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVER 1560
Query: 1561 NNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMG 1620
NNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMG
Sbjct: 1561 NNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMG 1620
Query: 1621 GGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRA 1680
GGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRA
Sbjct: 1621 GGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRA 1680
Query: 1681 AQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIP 1740
AQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIP
Sbjct: 1681 AQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIP 1740
Query: 1741 TNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGE 1800
TNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGE
Sbjct: 1741 TNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGE 1800
Query: 1801 DAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNS 1860
DAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNS
Sbjct: 1801 DAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNS 1860
Query: 1861 VRLML 1865
VRLML
Sbjct: 1861 VRLML 1865
>gi|18921093 transient receptor potential cation channel, subfamily M,
member 6 [Homo sapiens]
Length = 2022
Score = 1499 bits (3881), Expect = 0.0
Identities = 760/1254 (60%), Positives = 936/1254 (74%), Gaps = 42/1254 (3%)
Query: 2 SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMK 61
SQKSWI+ KREC IIPSSK+PHRC P CQ+CQ L+RC+CGRL+ HA S +
Sbjct: 12 SQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSWTIS 71
Query: 62 YSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVIL 121
+ K E+WSVEKHT +SPTD +G INFQ G H++ AKY+R SYDTK + +L
Sbjct: 72 AAKGKES-------EQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLL 124
Query: 122 QLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVA 181
L+LKEW+MELPKLVISVHGG+Q F + + K++ +GL+KAA TTGAWI+T G+NTGV+
Sbjct: 125 HLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVS 184
Query: 182 KHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNL 241
KHVGDALK H+S S RKI T+GI PWGVIEN+ DL+G+DVV YQTL NPLSKL LN++
Sbjct: 185 KHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLSKLTTLNSM 244
Query: 242 HSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVL 301
HSHFIL DDGTVGKYG E++LRR LEK ++ Q+IH R QGVPVV L+ EGGPNVIL+V
Sbjct: 245 HSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVW 304
Query: 302 EYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEA 361
E +++ PVVVCEGTGRAADLLA+ HK + G L + +II I+ TFNF ++
Sbjct: 305 ETVKDKD--PVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQS 362
Query: 362 LHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVD 421
HLFQ LMECM ++ IT+F S+E QD+D+AILTALLKGTN SA +QL L +AWDRVD
Sbjct: 363 KHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVD 422
Query: 422 IAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTK 481
IAK H+ +Y Q W +LEQAM DALVMDRV FVKLLIE GV++H+FLTIPRLEELYNTK
Sbjct: 423 IAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTK 482
Query: 482 QGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLG 541
QGPTN +L HLV+DVKQ L GY+ITLIDIGLV+EYL+G YR YTRK FR +YN+L
Sbjct: 483 QGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNL- 541
Query: 542 GNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKK 601
+ + S GNR + E H+ FI+TAQPY+ K +++ +K
Sbjct: 542 -------------YRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRK 588
Query: 602 RTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRS 661
++K++ V DDPE+ F YP N+LL+WA LMKRQ MA F WQHGEE+ KA++AC +YR+
Sbjct: 589 KSKEQNVS-DDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRA 647
Query: 662 MAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTC 721
MA+EAK+S +VDD SEELK YS FGQLA++LLE++F+Q+E MAM LLTYEL+NWSNSTC
Sbjct: 648 MAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTC 707
Query: 722 LKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAE 781
LKLAVS LRPFV+HTCTQMLL+DMWMGRL MRKNSW K+I+SI++PP IL LE+K+KAE
Sbjct: 708 LKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAE 767
Query: 782 MSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNE-MEIQMKSKKLP 840
MSH+PQSQD Q S+ N + E ++ + R D +N+ ++ + LP
Sbjct: 768 MSHVPQSQD-FQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLP 826
Query: 841 ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK 900
TRK Y FY APIVKFWF T+AYL FLML+T+ VLV+M+ PSVQEW+V YIFT AIE
Sbjct: 827 WTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEV 886
Query: 901 VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA 960
VREI +SE GK QK+KVW S+Y+N+++T+AI F GF LR+G D A
Sbjct: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWG---------DPPFHTA 937
Query: 961 GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA 1020
GRLIYC++IIFW+ RLLDF AVNQ AGPYV MI KM ANMFYIV+IMA+VLLSFGV RKA
Sbjct: 938 GRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKA 997
Query: 1021 ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY 1080
IL P E PSW+LA+DIVF PYWMI+GEVYA EIDVC++ C PG++LTPFLQAVY
Sbjct: 998 ILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ----PSCPPGSFLTPFLQAVY 1053
Query: 1081 LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS 1140
LFVQYIIMVNLLIAFFNNVYL +++ISN +WKY RY +IM YHEKP LPPPLI+LSH+
Sbjct: 1054 LFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGL 1113
Query: 1141 L---FCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERI 1197
L CC +++ G KL+L++ED KKLHDFEEQCVE YF+EK + + EERI
Sbjct: 1114 LLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERI 1173
Query: 1198 RVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTA 1251
RVT ERV +M Q+KE+ ++V++IK SL SLDSQ+GHLQDLSALTVDTLK L+A
Sbjct: 1174 RVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVLSA 1227
Score = 457 bits (1175), Expect = e-128
Identities = 219/295 (74%), Positives = 254/295 (86%), Gaps = 1/295 (0%)
Query: 1541 LTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPP-RGEPVTVYRLEESSPNILNNSM 1599
+++ K + +++YSA+ERNNLMRLSQ+IPFTPV GE +TVYRLEESSP L+ SM
Sbjct: 1696 ISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITVYRLEESSPLNLDKSM 1755
Query: 1600 SSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWS 1659
SSWSQ G A I+ LS+EEM GGLR+A++V TWSE DILK G ++I+KSFLPEVV TW
Sbjct: 1756 SSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQVFIVKSFLPEVVRTWH 1815
Query: 1660 SIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAV 1719
I++E TVLHLCLREIQQQRAAQKL + FNQ+KP++IPY+PRFLEVFL+YCHSA QW +
Sbjct: 1816 KIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVFLIYCHSANQWLTI 1875
Query: 1720 EECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPS 1779
E+ MTGEFRKYNNNNGDEI PTNTLEE+MLAFSHWTYEYTRGELLVLDLQGVGENLTDPS
Sbjct: 1876 EKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPS 1935
Query: 1780 VIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKI 1834
VIK E K+S MVFGPANLGEDAI+NF AKHHCNSCCRKLKLPDLKRNDY+P++I
Sbjct: 1936 VIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCRKLKLPDLKRNDYSPERI 1990
>gi|154091314 transient receptor potential cation channel, subfamily
M, member 3 isoform k [Homo sapiens]
Length = 1707
Score = 1462 bits (3786), Expect = 0.0
Identities = 737/1296 (56%), Positives = 961/1296 (74%), Gaps = 79/1296 (6%)
Query: 2 SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAM- 60
+QKSWIE KRECV+IIPS+KDPHRC CGRL+ QH T S+++
Sbjct: 60 AQKSWIERAFYKRECVHIIPSTKDPHRCC-------------CGRLIGQHVGLTPSISVL 106
Query: 61 --KYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPE 118
+ ++ +L + Q+ E+WS+ KHT+ SPTDA+G I FQGG HS +A YVR+S+DTKP+
Sbjct: 107 QNEKNESRLSRNDIQS-EKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPD 165
Query: 119 VILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNT 178
++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TTGAWI TGGVNT
Sbjct: 166 LLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNT 225
Query: 179 GVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVL 238
GV +HVGDALK+HAS+S KICTIGIAPWG++EN+ DL+GRDVV PYQT+ NP+SKL VL
Sbjct: 226 GVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVL 285
Query: 239 NNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVIL 298
N++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVALI EGGPNVI
Sbjct: 286 NSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVIS 345
Query: 299 TVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQ 358
VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++ ++ TI+KTF + +
Sbjct: 346 IVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTR 405
Query: 359 NEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWD 418
+A HLF LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA DQL L LAW+
Sbjct: 406 TQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWN 465
Query: 419 RVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELY 478
RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+FLTI RLEELY
Sbjct: 466 RVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELY 525
Query: 479 NTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYN 538
NT+ GP+N L+HLVRDVK+GNLPP Y+I+LIDIGLVIEYLMGG YRC YTRKRFR +Y+
Sbjct: 526 NTRHGPSN-TLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYH 584
Query: 539 SLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEG 598
+L G P+ K+ + G D P R T
Sbjct: 585 NLFG-------------PKRPKALKLLGMEDD--------------IPLRRGRKTT---- 613
Query: 599 KKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKI 658
KKR ++ +D+DDPE FP+P +EL++WA LMKRQ MA F WQHGEE+MAKALVACK+
Sbjct: 614 -KKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKL 672
Query: 659 YRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSN 718
++MA+EA ++D+VDD S+EL S DFGQLAVELL+QS++QDE +AMKLLTYELKNWSN
Sbjct: 673 CKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSN 732
Query: 719 STCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKT 778
+TCL+LAV+++ R F+AHTC+QMLL+DMWMGRL MRKNS KVIL IL+PP+IL LE+K
Sbjct: 733 ATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKN 792
Query: 779 KAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEG-----KNEMEIQ 833
K +M ++ Q+Q+ H + E + T+E E + +L N G K+E E+Q
Sbjct: 793 KDDMPYMSQAQEIHLQEKEAEEP--EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQ 850
Query: 834 MKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYI 893
K + +P+ RK Y FY+APIVKFWF TLAY+G+LML+ ++VLV+ME+ PS QEWIVI+YI
Sbjct: 851 SKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYI 910
Query: 894 FTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAY 953
FT IEK+REI MSE GK+ QK+KVW +Y+N++D IAI+ F +G LR
Sbjct: 911 FTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRL---------Q 961
Query: 954 DNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLS 1013
D GR+IYC+NII+WY+RLLD VN+ GPYVMMIGKM+ +M Y V+IM +VL+S
Sbjct: 962 DQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMS 1021
Query: 1014 FGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEID------VCANDSVIPQI-- 1065
FGV R+AIL+P+E PSW LAK+I + PYWMI+GEV+A +ID D I Q+
Sbjct: 1022 FGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPP 1081
Query: 1066 CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK 1125
C G W+ P + A YL V I++VNLLIA FNN + +VK+ISN VWK+QRY IM +HE+
Sbjct: 1082 CKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHER 1141
Query: 1126 PVLPPPLIILSHIVSLFCCICKRRKK-----DKTSDGPKLFLTEEDQKKLHDFEEQCVEM 1180
PVLPPPLII SH+ +F +C R +K D+ G KLF+T+++ KK+HDFEEQC+E
Sbjct: 1142 PVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEE 1201
Query: 1181 YFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSA 1240
YF EKDD+F+S ++ERIRVT ERVE M ++++EV +R + +K SLQ++D ++ L+DL
Sbjct: 1202 YFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIG 1261
Query: 1241 LTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQ 1276
L+ LT + +E++K+ + + + + + ++ +
Sbjct: 1262 RMATALERLTGLERAESNKIRSRTSSDCTDAAYIVR 1297
>gi|154091320 transient receptor potential cation channel, subfamily
M, member 3 isoform a [Homo sapiens]
Length = 1554
Score = 1369 bits (3544), Expect = 0.0
Identities = 686/1187 (57%), Positives = 892/1187 (75%), Gaps = 62/1187 (5%)
Query: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
GAWI TGGVNTGV +HVGDALK+HAS+S KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
+ NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
Query: 288 LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDII 347
LI EGGPNVI VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++ ++
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241
Query: 348 STIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASA 407
TI+KTF + + +A HLF LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA
Sbjct: 242 VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301
Query: 408 FDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHK 467
DQL L LAW+RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+
Sbjct: 302 PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361
Query: 468 FLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCT 527
FLTI RLEELYNT+ GP+N L+HLVRDVK+GNLPP Y+I+LIDIGLVIEYLMGG YRC
Sbjct: 362 FLTISRLEELYNTRHGPSNT-LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCN 420
Query: 528 YTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPY 587
YTRKRFR +Y++L G P+ K+ + G D P
Sbjct: 421 YTRKRFRTLYHNLFG-------------PKRPKALKLLGMEDDI--------------PL 453
Query: 588 RPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEE 647
R T KKR ++ +D+DDPE FP+P +EL++WA LMKRQ MA F WQHGEE
Sbjct: 454 RRGRKTT-----KKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEE 508
Query: 648 SMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMK 707
+MAKALVACK+ ++MA+EA ++D+VDD S+EL S DFGQLAVELL+QS++QDE +AMK
Sbjct: 509 AMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMK 568
Query: 708 LLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILV 767
LLTYELKNWSN+TCL+LAV+++ R F+AHTC+QMLL+DMWMGRL MRKNS KVIL IL+
Sbjct: 569 LLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILL 628
Query: 768 PPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEG- 826
PP+IL LE+K K +M ++ Q+Q+ H + E + T+E E + +L N G
Sbjct: 629 PPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP--EKPTKEKEEEDMELTAMLGRNNGE 686
Query: 827 ----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLP 882
K+E E+Q K + +P+ RK Y FY+APIVKFWF TLAY+G+LML+ ++VLV+ME+ P
Sbjct: 687 SSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP 746
Query: 883 SVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLR 942
S QEWIVI+YIFT IEK+REI MSE GK+ QK+KVW +Y+N++D IAI+ F +G LR
Sbjct: 747 STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILR 806
Query: 943 FGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFY 1002
D GR+IYC+NII+WY+RLLD VN+ GPYVMMIGKM+ +M Y
Sbjct: 807 L---------QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMY 857
Query: 1003 IVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEID------VC 1056
V+IM +VL+SFGV R+AIL+P+E PSW LAK+I + PYWMI+GEV+A +ID
Sbjct: 858 FVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNET 917
Query: 1057 ANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQ 1114
D I Q+ C G W+ P + A YL V I++VNLLIA FNN + +VK+ISN VWK+Q
Sbjct: 918 REDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQ 977
Query: 1115 RYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKK-----DKTSDGPKLFLTEEDQKK 1169
RY IM +HE+PVLPPPLII SH+ +F +C R +K D+ G KLF+T+++ KK
Sbjct: 978 RYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKK 1037
Query: 1170 LHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLD 1229
+HDFEEQC+E YF EKDD+F+S ++ERIRVT ERVE M ++++EV +R + +K SLQ++D
Sbjct: 1038 VHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVD 1097
Query: 1230 SQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQ 1276
++ L+DL L+ LT + +E++K+ + + + + + ++ +
Sbjct: 1098 IRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVR 1144
>gi|154091318 transient receptor potential cation channel, subfamily
M, member 3 isoform d [Homo sapiens]
Length = 1544
Score = 1368 bits (3540), Expect = 0.0
Identities = 684/1192 (57%), Positives = 888/1192 (74%), Gaps = 82/1192 (6%)
Query: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
GAWI TGGVNTGV +HVGDALK+HAS+S KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
+ NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
Query: 288 LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDII 347
LI EGGPNVI VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++ ++
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241
Query: 348 STIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASA 407
TI+KTF + + +A HLF LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA
Sbjct: 242 VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301
Query: 408 FDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHK 467
DQL L LAW+RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+
Sbjct: 302 PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361
Query: 468 FLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCT 527
FLTI RLEELYNT+ GP+N L+HLVRDVK+GNLPP Y+I+LIDIGLVIEYLMGG YRC
Sbjct: 362 FLTISRLEELYNTRHGPSNT-LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCN 420
Query: 528 YTRKRFRLIYNSLGGNNR-----RSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIK 582
YTRKRFR +Y++L G R R GR T+
Sbjct: 421 YTRKRFRTLYHNLFGPKRDDIPLRRGRKTT------------------------------ 450
Query: 583 TAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLW 642
KKR ++ +D+DDPE FP+P +EL++WA LMKRQ MA F W
Sbjct: 451 -----------------KKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFW 493
Query: 643 QHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDE 702
QHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+EL S DFGQLAVELL+QS++QDE
Sbjct: 494 QHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDE 553
Query: 703 TMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVI 762
+AMKLLTYELKNWSN+TCL+LAV+++ R F+AHTC+QMLL+DMWMGRL MRKNS KVI
Sbjct: 554 QLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVI 613
Query: 763 LSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILD 822
L IL+PP+IL LE+K K +M ++ Q+Q+ H + E + T+E E + +L
Sbjct: 614 LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP--EKPTKEKEEEDMELTAMLG 671
Query: 823 SNEG-----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQ 877
N G K+E E+Q K + +P+ RK Y FY+APIVKFWF TLAY+G+LML+ ++VLV+
Sbjct: 672 RNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVK 731
Query: 878 MEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFI 937
ME+ PS QEWIVI+YIFT IEK+REI MSE GK+ QK+KVW +Y+N++D IAI+ F +
Sbjct: 732 MERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSV 791
Query: 938 GFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV 997
G LR D GR+IYC+NII+WY+RLLD VN+ GPYVMMIGKM+
Sbjct: 792 GMILRL---------QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMM 842
Query: 998 ANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEID--- 1054
+M Y V+IM +VL+SFGV R+AIL+P+E PSW LAK+I + PYWMI+GEV+A +ID
Sbjct: 843 IDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPC 902
Query: 1055 ---VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNI 1109
D I Q+ C G W+ P + A YL V I++VNLLIA FNN + +VK+ISN
Sbjct: 903 GQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQ 962
Query: 1110 VWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKK-----DKTSDGPKLFLTE 1164
VWK+QRY IM +HE+PVLPPPLII SH+ +F +C R +K D+ G KLF+T+
Sbjct: 963 VWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITD 1022
Query: 1165 EDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRS 1224
++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRVT ERVE M ++++EV +R + +K S
Sbjct: 1023 DELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKAS 1082
Query: 1225 LQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQ 1276
LQ++D ++ L+DL L+ LT + +E++K+ + + + + + ++ +
Sbjct: 1083 LQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVR 1134
>gi|154091312 transient receptor potential cation channel, subfamily
M, member 3 isoform b [Homo sapiens]
Length = 1566
Score = 1360 bits (3521), Expect = 0.0
Identities = 686/1199 (57%), Positives = 892/1199 (74%), Gaps = 74/1199 (6%)
Query: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
GAWI TGGVNTGV +HVGDALK+HAS+S KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
+ NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
Query: 288 LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDII 347
LI EGGPNVI VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++ ++
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241
Query: 348 STIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASA 407
TI+KTF + + +A HLF LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA
Sbjct: 242 VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301
Query: 408 FDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHK 467
DQL L LAW+RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+
Sbjct: 302 PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361
Query: 468 FLTIPRLEELYNTKQGPTNPMLFHLVRDVKQ------------GNLPPGYKITLIDIGLV 515
FLTI RLEELYNT+ GP+N L+HLVRDVK+ GNLPP Y+I+LIDIGLV
Sbjct: 362 FLTISRLEELYNTRHGPSNT-LYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
Query: 516 IEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKM 575
IEYLMGG YRC YTRKRFR +Y++L G P+ K+ + G D
Sbjct: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFG-------------PKRPKALKLLGMEDDI---- 463
Query: 576 RHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQ 635
P R T KKR ++ +D+DDPE FP+P +EL++WA LMKRQ
Sbjct: 464 ----------PLRRGRKTT-----KKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQ 508
Query: 636 VMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLE 695
MA F WQHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+EL S DFGQLAVELL+
Sbjct: 509 KMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLD 568
Query: 696 QSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRK 755
QS++QDE +AMKLLTYELKNWSN+TCL+LAV+++ R F+AHTC+QMLL+DMWMGRL MRK
Sbjct: 569 QSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK 628
Query: 756 NSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVF 815
NS KVIL IL+PP+IL LE+K K +M ++ Q+Q+ H + E + T+E E
Sbjct: 629 NSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP--EKPTKEKEEEDM 686
Query: 816 KEVRILDSNEG-----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLY 870
+ +L N G K+E E+Q K + +P+ RK Y FY+APIVKFWF TLAY+G+LML+
Sbjct: 687 ELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLF 746
Query: 871 TFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTI 930
++VLV+ME+ PS QEWIVI+YIFT IEK+REI MSE GK+ QK+KVW +Y+N++D I
Sbjct: 747 NYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLI 806
Query: 931 AIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYV 990
AI+ F +G LR D GR+IYC+NII+WY+RLLD VN+ GPYV
Sbjct: 807 AILLFSVGMILRL---------QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYV 857
Query: 991 MMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYA 1050
MMIGKM+ +M Y V+IM +VL+SFGV R+AIL+P+E PSW LAK+I + PYWMI+GEV+A
Sbjct: 858 MMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFA 917
Query: 1051 YEID------VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQ 1102
+ID D I Q+ C G W+ P + A YL V I++VNLLIA FNN + +
Sbjct: 918 DQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFE 977
Query: 1103 VKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKK-----DKTSDG 1157
VK+ISN VWK+QRY IM +HE+PVLPPPLII SH+ +F +C R +K D+ G
Sbjct: 978 VKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYG 1037
Query: 1158 PKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDR 1217
KLF+T+++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRVT ERVE M ++++EV +R
Sbjct: 1038 LKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNER 1097
Query: 1218 VNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQ 1276
+ +K SLQ++D ++ L+DL L+ LT + +E++K+ + + + + + ++ +
Sbjct: 1098 EHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVR 1156
>gi|154091316 transient receptor potential cation channel, subfamily
M, member 3 isoform e [Homo sapiens]
Length = 1556
Score = 1359 bits (3517), Expect = 0.0
Identities = 684/1204 (56%), Positives = 888/1204 (73%), Gaps = 94/1204 (7%)
Query: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
GAWI TGGVNTGV +HVGDALK+HAS+S KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
+ NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
Query: 288 LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDII 347
LI EGGPNVI VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG + ++ ++
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241
Query: 348 STIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASA 407
TI+KTF + + +A HLF LMECMK+KELITVF +GS+ HQDID+AILTALLKG NASA
Sbjct: 242 VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301
Query: 408 FDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHK 467
DQL L LAW+RVDIA++ +F+YGQQW VGSLEQAMLDALV+DRV FVKLLIENGVSMH+
Sbjct: 302 PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361
Query: 468 FLTIPRLEELYNTKQGPTNPMLFHLVRDVKQ------------GNLPPGYKITLIDIGLV 515
FLTI RLEELYNT+ GP+N L+HLVRDVK+ GNLPP Y+I+LIDIGLV
Sbjct: 362 FLTISRLEELYNTRHGPSNT-LYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
Query: 516 IEYLMGGTYRCTYTRKRFRLIYNSLGGNNR-----RSGRNTSSSTPQLRKSHESFGNRAD 570
IEYLMGG YRC YTRKRFR +Y++L G R R GR T+
Sbjct: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTT------------------ 462
Query: 571 KKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWAC 630
KKR ++ +D+DDPE FP+P +EL++WA
Sbjct: 463 -----------------------------KKREEEVDIDLDDPEINHFPFPFHELMVWAV 493
Query: 631 LMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLA 690
LMKRQ MA F WQHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+EL S DFGQLA
Sbjct: 494 LMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLA 553
Query: 691 VELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGR 750
VELL+QS++QDE +AMKLLTYELKNWSN+TCL+LAV+++ R F+AHTC+QMLL+DMWMGR
Sbjct: 554 VELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGR 613
Query: 751 LNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEI 810
L MRKNS KVIL IL+PP+IL LE+K K +M ++ Q+Q+ H + E + T+E
Sbjct: 614 LRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP--EKPTKEK 671
Query: 811 PMEVFKEVRILDSNEG-----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLG 865
E + +L N G K+E E+Q K + +P+ RK Y FY+APIVKFWF TLAY+G
Sbjct: 672 EEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIG 731
Query: 866 FLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFN 925
+LML+ ++VLV+ME+ PS QEWIVI+YIFT IEK+REI MSE GK+ QK+KVW +Y+N
Sbjct: 732 YLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWN 791
Query: 926 ISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQ 985
++D IAI+ F +G LR D GR+IYC+NII+WY+RLLD VN+
Sbjct: 792 VTDLIAILLFSVGMILRL---------QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKY 842
Query: 986 AGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIF 1045
GPYVMMIGKM+ +M Y V+IM +VL+SFGV R+AIL+P+E PSW LAK+I + PYWMI+
Sbjct: 843 LGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIY 902
Query: 1046 GEVYAYEID------VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFN 1097
GEV+A +ID D I Q+ C G W+ P + A YL V I++VNLLIA FN
Sbjct: 903 GEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFN 962
Query: 1098 NVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKK-----D 1152
N + +VK+ISN VWK+QRY IM +HE+PVLPPPLII SH+ +F +C R +K D
Sbjct: 963 NTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPD 1022
Query: 1153 KTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIK 1212
+ G KLF+T+++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRVT ERVE M ++++
Sbjct: 1023 ERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLE 1082
Query: 1213 EVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISK 1272
EV +R + +K SLQ++D ++ L+DL L+ LT + +E++K+ + + + + +
Sbjct: 1083 EVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAA 1142
Query: 1273 HLAQ 1276
++ +
Sbjct: 1143 YIVR 1146
>gi|154091308 transient receptor potential cation channel, subfamily
M, member 3 isoform f [Homo sapiens]
Length = 1579
Score = 1355 bits (3508), Expect = 0.0
Identities = 686/1212 (56%), Positives = 892/1212 (73%), Gaps = 87/1212 (7%)
Query: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
GAWI TGGVNTGV +HVGDALK+HAS+S KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHAR--------- 278
+ NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ R
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDS 181
Query: 279 ----------------IGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAA 322
IGQGVPVVALI EGGPNVI VLEYL+++PPVPVVVC+G+GRA+
Sbjct: 182 RLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRAS 241
Query: 323 DLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFH 382
D+LA+ HK +EEGG + ++ ++ TI+KTF + + +A HLF LMECMK+KELITVF
Sbjct: 242 DILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFR 301
Query: 383 IGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQA 442
+GS+ HQDID+AILTALLKG NASA DQL L LAW+RVDIA++ +F+YGQQW VGSLEQA
Sbjct: 302 MGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQA 361
Query: 443 MLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLP 502
MLDALV+DRV FVKLLIENGVSMH+FLTI RLEELYNT+ GP+N L+HLVRDVK+GNLP
Sbjct: 362 MLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT-LYHLVRDVKKGNLP 420
Query: 503 PGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSH 562
P Y+I+LIDIGLVIEYLMGG YRC YTRKRFR +Y++L G P+ K+
Sbjct: 421 PDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFG-------------PKRPKAL 467
Query: 563 ESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPL 622
+ G D P R T KKR ++ +D+DDPE FP+P
Sbjct: 468 KLLGMEDDI--------------PLRRGRKTT-----KKREEEVDIDLDDPEINHFPFPF 508
Query: 623 NELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQY 682
+EL++WA LMKRQ MA F WQHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+EL
Sbjct: 509 HELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHN 568
Query: 683 SNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQML 742
S DFGQLAVELL+QS++QDE +AMKLLTYELKNWSN+TCL+LAV+++ R F+AHTC+QML
Sbjct: 569 SRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQML 628
Query: 743 LSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENN 802
L+DMWMGRL MRKNS KVIL IL+PP+IL LE+K K +M ++ Q+Q+ H + E
Sbjct: 629 LTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP- 687
Query: 803 FQNITEEIPMEVFKEVRILDSNEG-----KNEMEIQMKSKKLPITRKFYAFYHAPIVKFW 857
+ T+E E + +L N G K+E E+Q K + +P+ RK Y FY+APIVKFW
Sbjct: 688 -EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFW 746
Query: 858 FNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIK 917
F TLAY+G+LML+ ++VLV+ME+ PS QEWIVI+YIFT IEK+REI MSE GK+ QK+K
Sbjct: 747 FYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVK 806
Query: 918 VWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLL 977
VW +Y+N++D IAI+ F +G LR D GR+IYC+NII+WY+RLL
Sbjct: 807 VWLQEYWNVTDLIAILLFSVGMILRL---------QDQPFRSDGRVIYCVNIIYWYIRLL 857
Query: 978 DFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIV 1037
D VN+ GPYVMMIGKM+ +M Y V+IM +VL+SFGV R+AIL+P+E PSW LAK+I
Sbjct: 858 DIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIF 917
Query: 1038 FHPYWMIFGEVYAYEID------VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQYIIMV 1089
+ PYWMI+GEV+A +ID D I Q+ C G W+ P + A YL V I++V
Sbjct: 918 YMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLV 977
Query: 1090 NLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRR 1149
NLLIA FNN + +VK+ISN VWK+QRY IM +HE+PVLPPPLII SH+ +F +C R
Sbjct: 978 NLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRW 1037
Query: 1150 KK-----DKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERV 1204
+K D+ G KLF+T+++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRVT ERV
Sbjct: 1038 RKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERV 1097
Query: 1205 EQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEI 1264
E M ++++EV +R + +K SLQ++D ++ L+DL L+ LT + +E++K+ +
Sbjct: 1098 ENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRT 1157
Query: 1265 TRELSISKHLAQ 1276
+ + + + ++ +
Sbjct: 1158 SSDCTDAAYIVR 1169
>gi|154091310 transient receptor potential cation channel, subfamily
M, member 3 isoform g [Homo sapiens]
Length = 1569
Score = 1354 bits (3504), Expect = 0.0
Identities = 684/1217 (56%), Positives = 888/1217 (72%), Gaps = 107/1217 (8%)
Query: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
GAWI TGGVNTGV +HVGDALK+HAS+S KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHAR--------- 278
+ NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ R
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDS 181
Query: 279 ----------------IGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAA 322
IGQGVPVVALI EGGPNVI VLEYL+++PPVPVVVC+G+GRA+
Sbjct: 182 RLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRAS 241
Query: 323 DLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFH 382
D+LA+ HK +EEGG + ++ ++ TI+KTF + + +A HLF LMECMK+KELITVF
Sbjct: 242 DILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFR 301
Query: 383 IGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQA 442
+GS+ HQDID+AILTALLKG NASA DQL L LAW+RVDIA++ +F+YGQQW VGSLEQA
Sbjct: 302 MGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQA 361
Query: 443 MLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLP 502
MLDALV+DRV FVKLLIENGVSMH+FLTI RLEELYNT+ GP+N L+HLVRDVK+GNLP
Sbjct: 362 MLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT-LYHLVRDVKKGNLP 420
Query: 503 PGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNR-----RSGRNTSSSTPQ 557
P Y+I+LIDIGLVIEYLMGG YRC YTRKRFR +Y++L G R R GR T+
Sbjct: 421 PDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTT----- 475
Query: 558 LRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKR 617
KKR ++ +D+DDPE
Sbjct: 476 ------------------------------------------KKREEEVDIDLDDPEINH 493
Query: 618 FPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSE 677
FP+P +EL++WA LMKRQ MA F WQHGEE+MAKALVACK+ ++MA+EA ++D+VDD S+
Sbjct: 494 FPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQ 553
Query: 678 ELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHT 737
EL S DFGQLAVELL+QS++QDE +AMKLLTYELKNWSN+TCL+LAV+++ R F+AHT
Sbjct: 554 ELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHT 613
Query: 738 CTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMD 797
C+QMLL+DMWMGRL MRKNS KVIL IL+PP+IL LE+K K +M ++ Q+Q+ H +
Sbjct: 614 CSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKE 673
Query: 798 DSENNFQNITEEIPMEVFKEVRILDSNEG-----KNEMEIQMKSKKLPITRKFYAFYHAP 852
E + T+E E + +L N G K+E E+Q K + +P+ RK Y FY+AP
Sbjct: 674 AEEP--EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAP 731
Query: 853 IVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKV 912
IVKFWF TLAY+G+LML+ ++VLV+ME+ PS QEWIVI+YIFT IEK+REI MSE GK+
Sbjct: 732 IVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKL 791
Query: 913 NQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFW 972
QK+KVW +Y+N++D IAI+ F +G LR D GR+IYC+NII+W
Sbjct: 792 LQKVKVWLQEYWNVTDLIAILLFSVGMILRL---------QDQPFRSDGRVIYCVNIIYW 842
Query: 973 YVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTL 1032
Y+RLLD VN+ GPYVMMIGKM+ +M Y V+IM +VL+SFGV R+AIL+P+E PSW L
Sbjct: 843 YIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKL 902
Query: 1033 AKDIVFHPYWMIFGEVYAYEID------VCANDSVIPQI--CGPGTWLTPFLQAVYLFVQ 1084
AK+I + PYWMI+GEV+A +ID D I Q+ C G W+ P + A YL V
Sbjct: 903 AKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVA 962
Query: 1085 YIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCC 1144
I++VNLLIA FNN + +VK+ISN VWK+QRY IM +HE+PVLPPPLII SH+ +F
Sbjct: 963 NILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQH 1022
Query: 1145 ICKRRKK-----DKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRV 1199
+C R +K D+ G KLF+T+++ KK+HDFEEQC+E YF EKDD+F+S ++ERIRV
Sbjct: 1023 LCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRV 1082
Query: 1200 TFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASK 1259
T ERVE M ++++EV +R + +K SLQ++D ++ L+DL L+ LT + +E++K
Sbjct: 1083 TSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNK 1142
Query: 1260 VHNEITRELSISKHLAQ 1276
+ + + + + + ++ +
Sbjct: 1143 IRSRTSSDCTDAAYIVR 1159
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 1169 bits (3025), Expect = 0.0
Identities = 622/1290 (48%), Positives = 856/1290 (66%), Gaps = 80/1290 (6%)
Query: 41 RCFCGRLVKQHACFTASLAMKYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGG 100
RC CG+ QH S ++ + Q E+WSV KHT+ PTD+YGV+ FQGG
Sbjct: 6 RCCCGQFTNQHIPPLPSATPSKNEEESKQVETQP-EKWSVAKHTQSYPTDSYGVLEFQGG 64
Query: 101 SHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGL 160
+S +A Y+R+SYDTKP+ +L L++K+WQ+ELPKL+ISVHGG+Q FE+ P++KQ+ GKGL
Sbjct: 65 GYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGL 124
Query: 161 IKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRD 220
IKAA+TTGAWI TGGV+TGV HVGDALK+H+S+S ++C IGIAPWG++EN+ DLVG+D
Sbjct: 125 IKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKD 184
Query: 221 VVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIG 280
V YQT+ NPLSKL+VLNN H+HFIL D+GT+GKYGAEV+LRR LEK I+ Q+I+ R+G
Sbjct: 185 VTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLG 244
Query: 281 QGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPD 340
QGVP+V L+ EGGPNV+ VLEYLQE PP+PVV+C+G+GRA+D+L++ HK EEGG + +
Sbjct: 245 QGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINE 304
Query: 341 AAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALL 400
+ ++ TI+KTFN+ + ++ LF +MECMK+KEL+TVF +GS+ QDI++AILTALL
Sbjct: 305 SLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALL 364
Query: 401 KGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQW-LVGSLEQAMLDALVMDRVAFVKLLI 459
KGTN SA DQL L LAW+RVDIA++ +FV+G W +GSL
Sbjct: 365 KGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPPMATT 424
Query: 460 ENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYL 519
+ G K +++E + P L + V ++Q L + + L+IE
Sbjct: 425 KGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLLIE-- 482
Query: 520 MGGTYRCTYTRKRFRLIYNS-LGGNNRR----SGRNTSSSTPQLRKSHESFG-------- 566
G + T R +YN+ LG N S+ P S G
Sbjct: 483 NGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMG 542
Query: 567 -----NRADKKEKMRHNHFIKTAQPYRPKI-----DTVMEEGKKKRTK---DEI-VDIDD 612
N K + +N+ +P K+ D +GKKK+ K +EI +D+DD
Sbjct: 543 GAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDD 602
Query: 613 PETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLV 672
P RF YP +EL++WA LMKRQ MA FLWQ GEESMAKALVACK+Y++MA+E+ +SDLV
Sbjct: 603 PAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLV 662
Query: 673 DDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRP 732
DD S++L S DFGQLA+ELL+QS++ DE +AMKLLTYELKNWSNSTCLKLAV+++ R
Sbjct: 663 DDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRD 722
Query: 733 FVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSH--IPQSQD 790
F+AHTC+QMLL+DMWMGRL MRKN KVI+ IL+PP IL LE++T + S+ +++D
Sbjct: 723 FIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKENED 782
Query: 791 AHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYH 850
+ ++++ N S +G E E K + +PI K FY+
Sbjct: 783 GKEKEEENTDANAD----------------AGSRKGDEENE-HKKQRSIPIGTKICEFYN 825
Query: 851 APIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAG 910
APIVKFWF T++YLG+L+L+ +V+LV+M+ PS+QEWIVI+YI + A+EK+REI MSE G
Sbjct: 826 APIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPG 885
Query: 911 KVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA-GRLIYCLNI 969
K++QKIKVW +Y+NI+D +AI +F IG LR N ++ GR+IYC++I
Sbjct: 886 KLSQKIKVWLQEYWNITDLVAISTFMIGAILRL----------QNQPYMGYGRVIYCVDI 935
Query: 970 IFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPS 1029
IFWY+R+LD VN+ GPYVMMIGKM+ +M Y VVIM +VL+SFGV R+AIL+P E PS
Sbjct: 936 IFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPS 995
Query: 1030 WTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIP-------------QICGPGTWLTPFL 1076
W LA++I + PYWMI+GEV+A +ID+ A + P C PG WLTP L
Sbjct: 996 WKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPAL 1055
Query: 1077 QAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILS 1136
A YL V I++VNLLIA FNN + +VK+ISN VWK+QRY IM +H++PVLPPP+IILS
Sbjct: 1056 MACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILS 1115
Query: 1137 HIVSLFCCICKRRKKDKTSD------GPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFH 1190
HI + + R +K + D G KLFL++E+ K+LH+FEEQCV+ +F EK+D+
Sbjct: 1116 HIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQ 1175
Query: 1191 SGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLT 1250
S S+ERIRVT ERVE M ++++E+ +R ++K SLQ++D ++ L++LS V+ L+ L
Sbjct: 1176 SSSDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNALENLA 1235
Query: 1251 AQKASEASKVHNEITRELSISKHLAQNLID 1280
S+ + + + E + L Q+ I+
Sbjct: 1236 GIDRSDLIQARSRASSECEATYLLRQSSIN 1265
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 506 bits (1302), Expect = e-142
Identities = 389/1325 (29%), Positives = 626/1325 (47%), Gaps = 233/1325 (17%)
Query: 2 SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMK 61
S SWI + K+ECVY + SSK G +CQ CG +QH
Sbjct: 58 SLSSWIPENIKKKECVYFVESSKLSDA---GKVVCQ------CGYTHEQHL--------- 99
Query: 62 YSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVIL 121
+ H Q + W +KH ++ PTDA+G I F G S + KYVR+S DT VI
Sbjct: 100 --EEATKPHTFQGTQ-WDPKKHVQEMPTDAFGDIVFTGLSQKVK-KYVRVSQDTPSSVIY 155
Query: 122 QLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVA 181
L+ + W +++P L+ISV GG + F + PR+K + +GL+K A TTGAWI+TGG +TGV
Sbjct: 156 HLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVM 215
Query: 182 KHVGDALKEHASRSSRK---ICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNP--LSKLN 236
K VG+A+++ + SS K + TIG+A WG + R L+ P + +L+ L
Sbjct: 216 KQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLT 275
Query: 237 VLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQ-RIHARIGQGVPVVALIFEGGPN 295
L++ HSHFILVDDGT G+YG E+ LR LEK I++Q + + +P+V ++ EGGP
Sbjct: 276 CLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPG 335
Query: 296 VILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDI-ISTIKKTF 354
+ T+ P VV EG+GR AD++A + NLP + DI IS I++
Sbjct: 336 TLHTIDNATTNG--TPCVVVEGSGRVADVIAQV-------ANLPVS---DITISLIQQKL 383
Query: 355 N---------FGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNA 405
+ F ++ + + + + ++R++L+TVF G D QD+DVAIL ALLK + +
Sbjct: 384 SVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRS 443
Query: 406 SAF-------DQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLL 458
QL L +AW+RVDIA++ +F+ QW L M AL+ ++ FVKL
Sbjct: 444 QDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLF 503
Query: 459 IENGVSMHKFLTIPRLEELYNTKQGPTNPMLFH------LVRDVKQGNLPPGY-KITLID 511
+ENGV + +F+T L LY LFH LV D ++ P ++ +
Sbjct: 504 LENGVQLKEFVTWDTLLYLYENLDPSC---LFHSKLQKVLVEDPERPACAPAAPRLQMHH 560
Query: 512 IGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADK 571
+ V+ L+G + Y R R
Sbjct: 561 VAQVLRELLGDFTQPLYPRPR--------------------------------------- 581
Query: 572 KEKMRHNHFIKTAQPY---RPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIW 628
HN ++ P + + V KR+ + DP + +LLIW
Sbjct: 582 -----HNDRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDP--------IRDLLIW 628
Query: 629 ACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQ 688
A + R+ +A +W ++ +A AL KI + ++ E + +D +SEE+ + ++
Sbjct: 629 AIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTD----SSEEMLALAEEYEH 684
Query: 689 LAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWM 748
A+ + + +R+DE A KLLT + W +TCL+LA+ ++ FV+H Q L+ +W
Sbjct: 685 RAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWW 744
Query: 749 GRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITE 808
G+L++ W +V L +L P +L
Sbjct: 745 GQLSVDNGLW-RVTLCMLAFPLLLT----------------------------------- 768
Query: 809 EIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLM 868
+ F+E R+ D P R AF+ AP+V F N L+Y FL
Sbjct: 769 --GLISFREKRLQDVGT--------------PAARA-RAFFTAPVVVFHLNILSYFAFLC 811
Query: 869 LYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMS--EAGKVNQKIKVWFSDYFNI 926
L+ +V++V + +PS E + ++F+ E++R++F E G + +K ++FSD++N
Sbjct: 812 LFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLM-KKAALYFSDFWNK 870
Query: 927 SDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQA 986
D AI+ F G R A Y GR+I L+ I + +RL+ +++
Sbjct: 871 LDVGAILLFVAGLTCRLIP----ATLYP------GRVILSLDFILFCLRLMHIFTISKTL 920
Query: 987 GPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFG 1046
GP ++++ +M+ ++F+ + ++A+ ++SFGV ++AIL +E L + V+H Y IFG
Sbjct: 921 GPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFG 980
Query: 1047 EVYAYEIDVCANDSVIPQICGP-GT---------------------WLTPFLQAVYLFVQ 1084
++ Y V N P+ C P GT WLT L +YL
Sbjct: 981 QIPGYIDGVNFN----PEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFT 1036
Query: 1085 YIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCC 1144
I+++NLLIA FN + QV+ ++ +WK+QR+ I YH +P PPP I+LSH+ LF
Sbjct: 1037 NILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLSHL-QLFIK 1095
Query: 1145 ICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERV 1204
+ K K L + ++ L +E E Y + + E++I +V
Sbjct: 1096 RVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKV 1155
Query: 1205 EQMCIQIKEVG--DRVNYIKRSLQSLDSQIGHLQDLSALTVDTLK-----------TLTA 1251
+ M + + ++ R +++ L SL+ Q+ V TL+ TL +
Sbjct: 1156 DAM-VDLLDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRASGFSSEADVPTLAS 1214
Query: 1252 QKASE 1256
QKA+E
Sbjct: 1215 QKAAE 1219
>gi|11225266 transient receptor potential cation channel, subfamily M,
member 5 [Homo sapiens]
Length = 1165
Score = 418 bits (1074), Expect = e-116
Identities = 333/1192 (27%), Positives = 562/1192 (47%), Gaps = 132/1192 (11%)
Query: 93 GVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRI 152
G +NF GGS R K+VR+ P V+ LLL EW + P LV+S+ G Q F + +
Sbjct: 26 GEVNF-GGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWL 84
Query: 153 KQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEH--ASRSSR-KICTIGIAPWGV 209
+ +L KGL+KAA +TGAWILT + G+A+HVG A+++H AS S++ ++ +G+A G
Sbjct: 85 RDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGR 144
Query: 210 IENRNDL--VGRDVVAPYQT----LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLR 263
+ +R L D Y PL L+ +NL SHFILV+ G GK LR
Sbjct: 145 VLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLD--SNL-SHFILVEPGPPGKGDGLTELR 201
Query: 264 RELEKTINQQRIHARIGQG---VPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGR 320
LEK I++QR G G +PV+ L+ G PN + + ++++ P ++V G+G
Sbjct: 202 LRLEKHISEQRAGYG-GTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGG 258
Query: 321 AADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITV 380
AD+LA + Q +P AE +F + + + L + L+TV
Sbjct: 259 IADVLAALVNQPHL--LVPKVAEKQFKEKFPSK-HFSWEDIVRWTKLLQNITSHQHLLTV 315
Query: 381 FHIGSDEHQDIDVAILTALLKGTNASA------FDQLILTLAWDRVDIAKNHVFVYGQQW 434
+ + +++D IL AL+K + + D+L L +AWDRVDIAK+ +F +W
Sbjct: 316 YDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEW 375
Query: 435 LVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVR 494
LE+ M+DALV ++ FV+L ++NG + FLT RL+ELY + + +LF L++
Sbjct: 376 KSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKS--LLFDLLQ 433
Query: 495 DVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSS 554
++ RL LG R +
Sbjct: 434 RKQE---------------------------------EARLTLAGLGTQQARE----PPA 456
Query: 555 TPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDE--IVDIDD 612
P HE D + + Q RP E+G KR + ++D++
Sbjct: 457 GPPAFSLHEVSRVLKDFLQDACRGFY----QDGRPGDRRRAEKGPAKRPTGQKWLLDLNQ 512
Query: 613 PETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLV 672
P +L +WA L R MA + W G+E +A AL ACKI + M++ +++
Sbjct: 513 KSEN----PWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAA 568
Query: 673 DDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRP 732
T E + +LA++L + + E A LL + WS +TCL LA + +
Sbjct: 569 RATREA------KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKA 622
Query: 733 FVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQS-QDA 791
F AH Q L+ +W G +M + +L + PA++ T +E + + +D
Sbjct: 623 FFAHDGVQAFLTRIWWG--DMAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLEDL 680
Query: 792 HQMTMDDSENN----FQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYA 847
+ D+E + Q+ EE+ E + G + + + +K
Sbjct: 681 QDLDSLDTEKSPLYGLQSRVEELV-----EAPRAQGDRGPRAVFLLTRWRK--------- 726
Query: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVVLVQME---QLPSVQEWIVIAYIFTYAIEKVRE- 903
F+ AP+ F N + Y FL L+T+V+LV Q PS E + ++FT +E++R+
Sbjct: 727 FWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQG 786
Query: 904 IFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRL 963
F E + +K ++ D +N D +AI F +G R F AGR
Sbjct: 787 FFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPS----------AFEAGRT 836
Query: 964 IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023
+ ++ + + +RL+ A+++Q GP ++++ +M+ ++F+ + +++ L+++GV +A+L+
Sbjct: 837 VLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLH 896
Query: 1024 PHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVC-ANDSVIPQICGPG--------TWLTP 1074
PH+ + + +++ PY IFG++ EID N S P + WL
Sbjct: 897 PHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVI 956
Query: 1075 FLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLII 1134
L +L V ++++NLLIA F+ + V+ +++ WK+QRY+ I+ YHE+P L PP I+
Sbjct: 957 LLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFIL 1016
Query: 1135 LSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSE 1194
LSH+ + K+ + K + DQK + +E E + ++ + +
Sbjct: 1017 LSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVV-TWETVQKENFLSKMEKRRRDSEG 1075
Query: 1195 ERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTL 1246
E +R T RV+ + K +G KR ++ L+SQI + L + D L
Sbjct: 1076 EVLRKTAHRVDFIA---KYLGGLREQEKR-IKCLESQINYCSVLVSSVADVL 1123
>gi|45935368 transient receptor potential cation channel, subfamily
M, member 3 isoform h [Homo sapiens]
Length = 230
Score = 362 bits (929), Expect = 2e-99
Identities = 167/229 (72%), Positives = 206/229 (89%)
Query: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
GAWI TGGVNTGV +HVGDALK+HAS+S KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVA 287
+ NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ RIGQGVPVVA
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
Query: 288 LIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGG 336
LI EGGPNVI VLEYL+++PPVPVVVC+G+GRA+D+LA+ HK +EEGG
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGG 230
>gi|55953096 transient receptor potential cation channel, subfamily
M, member 3 isoform c [Homo sapiens]
Length = 255
Score = 348 bits (893), Expect = 3e-95
Identities = 167/254 (65%), Positives = 206/254 (81%), Gaps = 25/254 (9%)
Query: 108 YVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTT 167
YVR+S+DTKP+++L L+ KEWQ+ELPKL+ISVHGG+Q FEL P++KQ+ GKGLIKAA+TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 168 GAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQT 227
GAWI TGGVNTGV +HVGDALK+HAS+S KICTIGIAPWG++EN+ DL+GRDVV PYQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 228 LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHAR--------- 278
+ NP+SKL VLN++HSHFIL D+GT GKYGAEV+LRR+LEK I+ Q+I+ R
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDS 181
Query: 279 ----------------IGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAA 322
IGQGVPVVALI EGGPNVI VLEYL+++PPVPVVVC+G+GRA+
Sbjct: 182 RLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRAS 241
Query: 323 DLLAYIHKQTEEGG 336
D+LA+ HK +EEGG
Sbjct: 242 DILAFGHKYSEEGG 255
>gi|21314671 transient receptor potential cation channel, subfamily
M, member 4 [Homo sapiens]
Length = 1214
Score = 255 bits (651), Expect = 3e-67
Identities = 183/537 (34%), Positives = 280/537 (52%), Gaps = 49/537 (9%)
Query: 3 QKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKY 62
++SWI K+ C I S DP G +CQ CGR H
Sbjct: 7 EQSWIPKIFKKKTCTTFIVDSTDP-----GGTLCQ------CGRPRTAHPA--------- 46
Query: 63 SDVKLGDHFNQAIEE-WSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVIL 121
V + D F A+ W + HT + PTDAYG ++F G + + ++RLS T P +
Sbjct: 47 --VAMEDAFGAAVVTVWDSDAHTTEKPTDAYGELDFTGAGRKH-SNFLRLSDRTDPAAVY 103
Query: 122 QLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVA 181
L+ + W P LV+SV GG L ++ LL +GL++AA +TGAWI+TGG++TG+
Sbjct: 104 SLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIG 163
Query: 182 KHVGDALKEH--ASRSSRKICTIGIAPWGVIENRNDLVG--RDVVAPYQTLLNPLSKLNV 237
+HVG A+++H AS K+ +G+APWGV+ NR+ L+ A Y+ +P +
Sbjct: 164 RHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQF 223
Query: 238 -LNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIH-ARIGQGVPVVALIFEGGPN 295
L+ +S F LVDDGT G G E R R LE I+QQ+ G +PV+ L+ +G
Sbjct: 224 PLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEK 283
Query: 296 VILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFN 355
++ + Q +P ++ G+G AAD LA + T G+ A + + I++ F
Sbjct: 284 MLTRIENATQAQ--LPCLLVAGSGGAADCLAETLEDTLAPGS-GGARQGEARDRIRRFFP 340
Query: 356 FGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLK---GTNASAF-DQL 411
G E L + M RKEL+TV+ D ++ + +L AL+K + ASA+ D+L
Sbjct: 341 KGDLEVLQ--AQVERIMTRKELLTVYS-SEDGSEEFETIVLKALVKACGSSEASAYLDEL 397
Query: 412 ILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTI 471
L +AW+RVDIA++ +F QW LE +++DAL+ DR FV+LLI +G+S+ FLT
Sbjct: 398 RLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTP 457
Query: 472 PRLEELYNTKQGPTNPMLFHLVRDVKQ--GNLPPGYK-----ITLIDIGLVIEYLMG 521
RL +LY+ P+N ++ +L+ G P K + D+G V+ L+G
Sbjct: 458 MRLAQLYSA--APSNSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLG 512
Score = 239 bits (611), Expect = 1e-62
Identities = 166/653 (25%), Positives = 313/653 (47%), Gaps = 63/653 (9%)
Query: 621 PLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELK 680
P ++LL+WA L+ R MA + W+ G +++ AL AC + R MA ++ + K
Sbjct: 558 PWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAE----EAARRK 613
Query: 681 QYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQ 740
+ F + V+L + +R E A +LL W ++TCL+LA+ + R F A Q
Sbjct: 614 DLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQ 673
Query: 741 MLLSDMWMGRLNMRKNSWYKVILSILVPPAI---LLLEYKTKAEMSHIPQSQDAHQMTMD 797
LL+ W G + W ++L+ PP I L+ K++ E + D +
Sbjct: 674 SLLTQKWWGDMASTTPIW-ALVLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVING 732
Query: 798 DSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFW 857
+ + E+ P+ V ++ G + R+++ F+ AP+ F
Sbjct: 733 EGPVGTADPAEKTPLGVPRQSGRPGCCGG--------RCGGRRCLRRWFHFWGAPVTIFM 784
Query: 858 FNTLAYLGFLMLYTFVVLVQMEQL-PSVQEWIVIAYIFTYAIEKVREIFMSEAG------ 910
N ++YL FL+L++ V+LV + P E ++ + FT E++R+ G
Sbjct: 785 GNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGG 844
Query: 911 ------KVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLI 964
++Q+++++ +D +N D +A+ F +G G R ++ GR +
Sbjct: 845 PGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRL----------TPGLYHLGRTV 894
Query: 965 YCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYP 1024
C++ + + VRLL VN+Q GP ++++ KM+ ++F+ + + + L+++GV + +L P
Sbjct: 895 LCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRP 954
Query: 1025 HEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVC----ANDSVIPQICG--PG--------- 1069
++ ++ + + + PY IFG++ ++DV +N S P PG
Sbjct: 955 RDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQ 1014
Query: 1070 --TWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPV 1127
WL L ++L V I++VNLLIA F+ + +V+ S++ WK QRY I +H +P
Sbjct: 1015 YANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPA 1074
Query: 1128 LPPPLIILSHIVSLFCCICKRRKKDKTSDGP----KLFLTEEDQKKLHDFEEQCVEMYFN 1183
L PP I++SH+ L +C+R + + S +++L++E ++KL +E E +
Sbjct: 1075 LAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLL 1134
Query: 1184 EKDDKFHSGSEERIRVTFERVEQMCIQ---IKEVGDRVNYIKRSLQSLDSQIG 1233
+ ER++ T ++V+ Q I+E R+ ++R +Q +G
Sbjct: 1135 ARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLG 1187
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 240 bits (612), Expect = 1e-62
Identities = 158/490 (32%), Positives = 262/490 (53%), Gaps = 49/490 (10%)
Query: 5 SWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSD 64
++I++ KRECV+ SK C CG QH
Sbjct: 43 NFIQANFKKRECVFFTKDSKATENV------------CKCGYAQSQHM------------ 78
Query: 65 VKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLL 124
G NQ+ E+W+ +KHT++ PTDA+G I F+ + + KY+RLS DT E++ +LL
Sbjct: 79 --EGTQINQS-EKWNYKKHTKEFPTDAFGDIQFE--TLGKKGKYIRLSCDTDAEILYELL 133
Query: 125 LKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHV 184
+ W ++ P LVISV GG + F L PR++++ + LI A + GAWILTGG + G+ K++
Sbjct: 134 TQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYI 192
Query: 185 GDALKEHA-SRSSRK-ICTIGIAPWGVIENRNDLVGRDVVAPY---QTLLNPLSK--LNV 237
G+ ++++ SRSS + I IGIA WG++ NR+ L+ Y Q L++ ++ L +
Sbjct: 193 GEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYI 252
Query: 238 LNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIH-ARIGQGVPVVALIFEGGPNV 296
L+N H+H +LVD+G G E +LR +LEK I+++ I + G +P+V GG
Sbjct: 253 LDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKET 312
Query: 297 ILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFN- 355
+ + ++ +P VV EG+G+ AD++A + + E A + ++ + +T +
Sbjct: 313 LKAINTSIKNK--IPCVVVEGSGQIADVIASLVEV--EDALTSSAVKEKLVRFLPRTVSR 368
Query: 356 FGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFD------ 409
+ E + L E ++ L+TV + + + AI AL K + S D
Sbjct: 369 LPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNG 428
Query: 410 QLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFL 469
QL L L W+++D+A + +F ++W L++ M AL+ DR FV+L +ENG+++ KFL
Sbjct: 429 QLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFL 488
Query: 470 TIPRLEELYN 479
T L EL++
Sbjct: 489 THDVLTELFS 498
Score = 147 bits (372), Expect = 7e-35
Identities = 98/400 (24%), Positives = 198/400 (49%), Gaps = 49/400 (12%)
Query: 845 FYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREI 904
+ AF+ +P V F +N + Y+ FL+L+ +V+L+ +P E ++ + +F ++VR+
Sbjct: 727 YVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQW 786
Query: 905 FMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLI 964
+++ +F+D +N+ DT+ + F G R + N ++ Y +GR+I
Sbjct: 787 YVNGVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSS-NKSSLY------SGRVI 831
Query: 965 YCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYP 1024
+CL+ I + +RL+ V++ GP ++M+ +M+ ++F+ + + A+ +++FGV R+ IL
Sbjct: 832 FCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQ 891
Query: 1025 HEAPSWTLAKDIVFHPYWMIFGEV------YAYEIDVCA-------------NDSVIPQI 1065
+E + + +++ PY +FG+V Y+ C ++ +P+
Sbjct: 892 NEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRF 951
Query: 1066 CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK 1125
W+T L +Y+ I++VNLL+A F V+ ++ VWK+QRY + Y +
Sbjct: 952 ---PEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSR 1008
Query: 1126 PVLPPPLIILSH----IVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMY 1181
+P P I+ ++ + F C C K+K + ED + L +E E Y
Sbjct: 1009 LNIPFPFIVFAYFYMVVKKCFKCCC----KEKNMESSVCCFKNEDNETL-AWEGVMKENY 1063
Query: 1182 FNEKDDKFHSGSEE---RIRVTFERVEQMCIQIKEVGDRV 1218
+ + K + SEE R R ++ + +KE+ +++
Sbjct: 1064 LVKINTKANDTSEEMRHRFRQLDTKLNDLKGLLKEIANKI 1103
Score = 85.9 bits (211), Expect = 3e-16
Identities = 48/152 (31%), Positives = 80/152 (52%), Gaps = 5/152 (3%)
Query: 620 YPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEEL 679
+PL L IWA L ++ +++ +W+ AL A K+ +++A + K SEEL
Sbjct: 559 HPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLA-KVKNDINAAGESEEL 617
Query: 680 KQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCT 739
+N++ AVEL + + DE +A +LL Y + W S CL+LAV + + F+A
Sbjct: 618 ---ANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGV 674
Query: 740 QMLLSDMWMGRLNMRKNSWYKVILSILVPPAI 771
Q LS W G ++ +W K+IL + + P +
Sbjct: 675 QNFLSKQWYGEISRDTKNW-KIILCLFIIPLV 705
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 84.0 bits (206), Expect = 1e-15
Identities = 85/370 (22%), Positives = 160/370 (43%), Gaps = 61/370 (16%)
Query: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
F P +KF +T +YL FL L L + P++ EW+++ ++ + +
Sbjct: 185 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 244
Query: 901 VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
+++++ G + I W++ D+ S +A IS I +++ A N ++D H
Sbjct: 245 IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 300
Query: 958 FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017
+ ++ + IF +RL+ N GP + +G+M+ ++ + I LVLL+F
Sbjct: 301 TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 360
Query: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062
+ + +E K I +F +W IFG + Y +V A
Sbjct: 361 LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 418
Query: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118
T F+ A Y + ++++N+LIA NN Y + ++I WK+ R
Sbjct: 419 ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 469
Query: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDKTSDGPKLFLT-----EE 1165
M+Y E+ LP P ++ SL+ I CK++ + K P+ F T +
Sbjct: 470 WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK----PESFGTIGRRAAD 525
Query: 1166 DQKKLHDFEE 1175
+ ++ H ++E
Sbjct: 526 NLRRHHQYQE 535
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 84.0 bits (206), Expect = 1e-15
Identities = 85/370 (22%), Positives = 160/370 (43%), Gaps = 61/370 (16%)
Query: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
F P +KF +T +YL FL L L + P++ EW+++ ++ + +
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 901 VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
+++++ G + I W++ D+ S +A IS I +++ A N ++D H
Sbjct: 418 IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473
Query: 958 FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017
+ ++ + IF +RL+ N GP + +G+M+ ++ + I LVLL+F
Sbjct: 474 TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533
Query: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062
+ + +E K I +F +W IFG + Y +V A
Sbjct: 534 LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591
Query: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118
T F+ A Y + ++++N+LIA NN Y + ++I WK+ R
Sbjct: 592 ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 642
Query: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDKTSDGPKLFLT-----EE 1165
M+Y E+ LP P ++ SL+ I CK++ + K P+ F T +
Sbjct: 643 WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK----PESFGTIGRRAAD 698
Query: 1166 DQKKLHDFEE 1175
+ ++ H ++E
Sbjct: 699 NLRRHHQYQE 708
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 84.0 bits (206), Expect = 1e-15
Identities = 85/370 (22%), Positives = 160/370 (43%), Gaps = 61/370 (16%)
Query: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
F P +KF +T +YL FL L L + P++ EW+++ ++ + +
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 901 VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
+++++ G + I W++ D+ S +A IS I +++ A N ++D H
Sbjct: 418 IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473
Query: 958 FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017
+ ++ + IF +RL+ N GP + +G+M+ ++ + I LVLL+F
Sbjct: 474 TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533
Query: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062
+ + +E K I +F +W IFG + Y +V A
Sbjct: 534 LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591
Query: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118
T F+ A Y + ++++N+LIA NN Y + ++I WK+ R
Sbjct: 592 ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 642
Query: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDKTSDGPKLFLT-----EE 1165
M+Y E+ LP P ++ SL+ I CK++ + K P+ F T +
Sbjct: 643 WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK----PESFGTIGRRAAD 698
Query: 1166 DQKKLHDFEE 1175
+ ++ H ++E
Sbjct: 699 NLRRHHQYQE 708
>gi|7706747 transient receptor potential cation channel, subfamily C,
member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 84.0 bits (206), Expect = 1e-15
Identities = 85/370 (22%), Positives = 160/370 (43%), Gaps = 61/370 (16%)
Query: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
F P +KF +T +YL FL L L + P++ EW+++ ++ + +
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 901 VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
+++++ G + I W++ D+ S +A IS I +++ A N ++D H
Sbjct: 418 IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473
Query: 958 FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017
+ ++ + IF +RL+ N GP + +G+M+ ++ + I LVLL+F
Sbjct: 474 TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533
Query: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062
+ + +E K I +F +W IFG + Y +V A
Sbjct: 534 LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591
Query: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118
T F+ A Y + ++++N+LIA NN Y + ++I WK+ R
Sbjct: 592 ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 642
Query: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDKTSDGPKLFLT-----EE 1165
M+Y E+ LP P ++ SL+ I CK++ + K P+ F T +
Sbjct: 643 WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK----PESFGTIGRRAAD 698
Query: 1166 DQKKLHDFEE 1175
+ ++ H ++E
Sbjct: 699 NLRRHHQYQE 708
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 83.6 bits (205), Expect = 2e-15
Identities = 80/343 (23%), Positives = 148/343 (43%), Gaps = 52/343 (15%)
Query: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
F P +KF +T +YL FL L L + P++ EW+++ ++ + +
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 901 VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
+++++ G + I W++ D+ S +A IS I +++ A N ++D H
Sbjct: 418 IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473
Query: 958 FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017
+ ++ + IF +RL+ N GP + +G+M+ ++ + I LVLL+F
Sbjct: 474 TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533
Query: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062
+ + +E K I +F +W IFG + Y +V A
Sbjct: 534 LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591
Query: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118
T F+ A Y + ++++N+LIA NN Y + ++I WK+ R
Sbjct: 592 ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 642
Query: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDK 1153
M+Y E+ LP P ++ SL+ I CK++ + K
Sbjct: 643 WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK 685
>gi|6912736 transient receptor potential cation channel, subfamily C,
member 5 [Homo sapiens]
Length = 973
Score = 75.1 bits (183), Expect = 6e-13
Identities = 70/324 (21%), Positives = 138/324 (42%), Gaps = 54/324 (16%)
Query: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQL-----------PSVQEWIVIAYIFTY 896
F P +KF +T +YL FL F++L+ + + P+V EW+++ ++ +
Sbjct: 359 FIKKPFIKFICHTASYLTFL----FMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGF 414
Query: 897 AIEKVREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYD 954
+++E++ G + I W++ D+ S +A IS I +++
Sbjct: 415 IWGEIKEMW---DGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
Query: 955 NHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSF 1014
H + ++ ++ I +RL+ N GP + +G+M+ ++ + I LVLL+F
Sbjct: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
Query: 1015 GVPRKAILYPHEAPS------------------WTLAKDIVFHPYWMIFGEVYAYEIDVC 1056
+ + +E + ++ + + +W +FG + Y +V
Sbjct: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591
Query: 1057 ANDSVIPQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWK 1112
A T F+ A Y + ++++N+LIA NN Y + ++I WK
Sbjct: 592 ARHE-----------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWK 640
Query: 1113 YQRYHFIMAY-HEKPVLPPPLIIL 1135
+ R M+Y E LPPP I+
Sbjct: 641 FARTKLWMSYFDEGGTLPPPFNII 664
>gi|148596992 heart alpha-kinase [Homo sapiens]
Length = 2170
Score = 70.1 bits (170), Expect = 2e-11
Identities = 48/138 (34%), Positives = 65/138 (47%), Gaps = 18/138 (13%)
Query: 1700 PRFLEVFLLYCHSAGQWFA-VEECMTGEFRKYNNNNGDEIIPTNTLEEI---MLAFSHWT 1755
P + +FL++ +A VEE + GEF KY+ +G EI E F HW
Sbjct: 2009 PEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWV 2068
Query: 1756 YEYTRGELLVLDLQGVGENLTDPSVIKAEE-----KRSCDMVFGPANLGEDAIKNFRAKH 1810
Y+ T G LLV D+QGVG LTD + + K +C M F I F+A H
Sbjct: 2069 YQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTF---------IDQFKALH 2119
Query: 1811 HCNSCCRKLKLPDLKRND 1828
CN C+ L L L+ N+
Sbjct: 2120 QCNKYCKMLGLKSLQNNN 2137
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 67.8 bits (164), Expect = 1e-10
Identities = 66/303 (21%), Positives = 133/303 (43%), Gaps = 45/303 (14%)
Query: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
F P +KF +T +YL FL L L + P++ EW+++ ++ + +
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 901 VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
+++++ G + I W++ D+ S +A IS I +++ A N ++D H
Sbjct: 418 IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473
Query: 958 FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSF--- 1014
+ ++ + IF +RL+ N GP + +G+M+ ++ + I LVLL+F
Sbjct: 474 TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533
Query: 1015 ------------GVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVI 1062
G+ K I + +++ + + +W IFG + Y +V A
Sbjct: 534 LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591
Query: 1063 PQICGPGTWLTPFLQA----VYLFVQYIIMVNLLIAFFNNVY-LQVKAISNIVWKYQRYH 1117
T F+ A Y + ++++N+LIA NN Y L + ++ + ++ +Y
Sbjct: 592 ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNLRRHHQYQ 642
Query: 1118 FIM 1120
+M
Sbjct: 643 EVM 645
>gi|9558749 elongation factor-2 kinase [Homo sapiens]
Length = 725
Score = 62.8 bits (151), Expect = 3e-09
Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 7/105 (6%)
Query: 1717 FAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLT 1776
F +E + G++ KYN+N+G + + + AFSH+T+E + +L+V+D+QGVG+ T
Sbjct: 226 FHLEHYIEGKYIKYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYT 283
Query: 1777 DPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKL 1821
DP + + D FG NLG + F H CN C + L
Sbjct: 284 DPQI---HTETGTD--FGDGNLGVRGMALFFYSHACNRICESMGL 323
>gi|5730102 transient receptor potential cation channel, subfamily C,
member 6 [Homo sapiens]
Length = 931
Score = 62.0 bits (149), Expect = 5e-09
Identities = 43/192 (22%), Positives = 89/192 (46%), Gaps = 12/192 (6%)
Query: 964 IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAI-- 1021
+Y + ++ + R+ L N+ GP + +G+ V ++F +VI +V ++F + +
Sbjct: 598 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYS 657
Query: 1022 --LYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAV 1079
+ + ++T ++ +W IFG + + N I I L V
Sbjct: 658 YYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENI-------GYVLYGV 710
Query: 1080 YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK-PVLPPPLIILSHI 1138
Y I+++N+LIA N+ + +++ +++ WK+ R +Y E+ LP P ++
Sbjct: 711 YNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSP 770
Query: 1139 VSLFCCICKRRK 1150
SLF + K +K
Sbjct: 771 KSLFYLLLKLKK 782
>gi|9966865 transient receptor potential cation channel, subfamily C,
member 7 [Homo sapiens]
Length = 862
Score = 60.8 bits (146), Expect = 1e-08
Identities = 41/189 (21%), Positives = 86/189 (45%), Gaps = 12/189 (6%)
Query: 964 IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023
+Y + ++ + R+ L N+ GP + +G+ V ++F +VI +V ++F + +
Sbjct: 543 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYS 602
Query: 1024 PHEA----PSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAV 1079
+ P++T ++ +W IFG + + + I I L V
Sbjct: 603 YYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENI-------GYVLYGV 655
Query: 1080 YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAY-HEKPVLPPPLIILSHI 1138
Y ++++N+LIA NN Y +++ +++ WK+ R ++Y E LP P ++
Sbjct: 656 YNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSP 715
Query: 1139 VSLFCCICK 1147
S + I +
Sbjct: 716 KSFYYLIMR 724
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 60.1 bits (144), Expect = 2e-08
Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 22/204 (10%)
Query: 964 IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023
+Y + ++ + R+ L N+ GP + +G+ V ++F +V+ +V +F + ILY
Sbjct: 614 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGM-FILY 672
Query: 1024 PHEA-----PSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQA 1078
+ ++T ++ +W IFG + + + I I L
Sbjct: 673 SYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENI-------GYVLYG 725
Query: 1079 VYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK-PVLPPPLIILSH 1137
+Y ++++N+LIA N+ Y +++ S++ WK+ R ++Y + LPPP ++
Sbjct: 726 IYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPS 785
Query: 1138 IVSLFCCI--------CKRRKKDK 1153
S I C+RR+ K
Sbjct: 786 PKSFVYFIMRIVNFPKCRRRRLQK 809
>gi|4507687 transient receptor potential cation channel, subfamily C,
member 3 isoform b [Homo sapiens]
Length = 848
Score = 60.1 bits (144), Expect = 2e-08
Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 22/204 (10%)
Query: 964 IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023
+Y + ++ + R+ L N+ GP + +G+ V ++F +V+ +V +F + ILY
Sbjct: 541 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGM-FILY 599
Query: 1024 PHEA-----PSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQA 1078
+ ++T ++ +W IFG + + + I I L
Sbjct: 600 SYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENI-------GYVLYG 652
Query: 1079 VYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK-PVLPPPLIILSH 1137
+Y ++++N+LIA N+ Y +++ S++ WK+ R ++Y + LPPP ++
Sbjct: 653 IYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPS 712
Query: 1138 IVSLFCCI--------CKRRKKDK 1153
S I C+RR+ K
Sbjct: 713 PKSFVYFIMRIVNFPKCRRRRLQK 736
>gi|156151443 alpha-kinase 1 [Homo sapiens]
Length = 1244
Score = 53.9 bits (128), Expect = 1e-06
Identities = 54/175 (30%), Positives = 80/175 (45%), Gaps = 24/175 (13%)
Query: 1662 YKEDTVLHLCLREIQQQRAAQKLTFAFN-----QMKPKSIPYSPRFLEVFLLYCHSAGQW 1716
YKE L ++++Q AQ FN Q P I Y P + + +L +
Sbjct: 1069 YKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTI-LLILEDKTIKGC 1127
Query: 1717 FAVEECMTGEFRKYNNNNGDEIIPTN-TLEEIMLAFSHWTYEYTRGELLVLDLQG-VGEN 1774
+VE + GEF K +NN +++ T E LA+ H++YE++ +V+DLQG V N
Sbjct: 1128 ISVEPYILGEFVKLSNNT--KVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGN 1185
Query: 1775 ------LTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHH--CNSCCRKLKL 1821
LTDP + ++K VF N G+ I F H CN C +L L
Sbjct: 1186 GKGLIYLTDPQIHSVDQK-----VF-TTNFGKRGIFYFFNNQHVECNEICHRLSL 1234
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,917,602
Number of Sequences: 37866
Number of extensions: 3299069
Number of successful extensions: 8493
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 8244
Number of HSP's gapped (non-prelim): 184
length of query: 1865
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1748
effective length of database: 13,817,196
effective search space: 24152458608
effective search space used: 24152458608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.