BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens] (1505 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens] 2938 0.0 gi|116517292 cut-like 2 [Homo sapiens] 1050 0.0 gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens] 746 0.0 gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens] 738 0.0 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 87 2e-16 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 87 2e-16 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 87 2e-16 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 87 2e-16 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 87 2e-16 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 87 2e-16 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 87 2e-16 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 87 2e-16 gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 82 3e-15 gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 81 9e-15 gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 81 9e-15 gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 81 9e-15 gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 81 9e-15 gi|122937424 one cut homeobox 3 [Homo sapiens] 79 3e-14 gi|24307887 one cut homeobox 1 [Homo sapiens] 78 6e-14 gi|21735548 centrosomal protein 2 [Homo sapiens] 77 1e-13 gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 77 1e-13 gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 77 1e-13 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 77 1e-13 gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 75 6e-13 gi|4506751 restin isoform a [Homo sapiens] 74 8e-13 gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens] 74 1e-12 gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 74 1e-12 gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens] 73 2e-12 gi|87298937 centrosomal protein 110kDa [Homo sapiens] 72 3e-12 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 71 7e-12 >gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens] Length = 1505 Score = 2938 bits (7617), Expect = 0.0 Identities = 1505/1505 (100%), Positives = 1505/1505 (100%) Query: 1 MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF 60 MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF Sbjct: 1 MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF 60 Query: 61 QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE 120 QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE Sbjct: 61 QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE 120 Query: 121 TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ Sbjct: 121 TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN Sbjct: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA Sbjct: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 Query: 301 QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI 360 QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI Sbjct: 301 QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI 360 Query: 361 LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPES 420 LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPES Sbjct: 361 LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPES 420 Query: 421 RRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFAL 480 RRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFAL Sbjct: 421 RRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFAL 480 Query: 481 NSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE 540 NSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE Sbjct: 481 NSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE 540 Query: 541 SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT 600 SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT Sbjct: 541 SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT 600 Query: 601 VRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRI 660 VRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRI Sbjct: 601 VRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRI 660 Query: 661 RASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQ 720 RASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQ Sbjct: 661 RASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQ 720 Query: 721 QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPN 780 QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPN Sbjct: 721 QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPN 780 Query: 781 PPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEE 840 PPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEE Sbjct: 781 PPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEE 840 Query: 841 AKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA 900 AKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA Sbjct: 841 AKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA 900 Query: 901 SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNG 960 SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNG Sbjct: 901 SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNG 960 Query: 961 ICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQ 1020 ICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQ Sbjct: 961 ICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQ 1020 Query: 1021 QQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP 1080 QQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP Sbjct: 1021 QQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP 1080 Query: 1081 IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLT 1140 IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLT Sbjct: 1081 IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLT 1140 Query: 1141 DNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMD 1200 DNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMD Sbjct: 1141 DNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMD 1200 Query: 1201 MKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK 1260 MKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK Sbjct: 1201 MKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK 1260 Query: 1261 RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASD 1320 RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASD Sbjct: 1261 RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASD 1320 Query: 1321 SPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGT 1380 SPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGT Sbjct: 1321 SPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGT 1380 Query: 1381 PGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPP 1440 PGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPP Sbjct: 1381 PGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPP 1440 Query: 1441 PSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEP 1500 PSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEP Sbjct: 1441 PSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEP 1500 Query: 1501 IEWEF 1505 IEWEF Sbjct: 1501 IEWEF 1505 >gi|116517292 cut-like 2 [Homo sapiens] Length = 1486 Score = 1050 bits (2714), Expect = 0.0 Identities = 691/1580 (43%), Positives = 916/1580 (57%), Gaps = 194/1580 (12%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 RL++EL++ A+ L+ RQ+ESE S K LIE REFKKN PE++R+ VAP+LKSFQ E+ AL Sbjct: 19 RLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIREMVAPVLKSFQAEVVAL 78 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE--TLEEY 125 SKRS+EAEAAFL+VYK+LI+ PDPVP + + L ++Q + Q R+ T + Sbjct: 79 SKRSQEAEAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQP-PSFDPSGQPRRDLHTSWKR 137 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185 N E K Q + E + + AL E LQ + AEK++ LQE Q++ Sbjct: 138 NPELLSPKEQREGTSPAGPTLTEGSRLPGIPGK--ALLTETLLQRNEAEKQKGLQEVQIT 195 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEV 245 ++L EAE K++ L +AL+ T+ EL +L+ KYDEE +KADE+ +IMT+LE+ANQRAE Sbjct: 196 LAARLGEAEEKIKVLHSALKATQAELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEA 255 Query: 246 AQREAETLREQLSSANHSLQLASQIQKAPDVEQA-IEVLTRSSLEVELAAKEREIAQLVE 304 AQRE E+LREQL+S N S++LA + P ++ + + LE LA+K+REI +L++ Sbjct: 256 AQREVESLREQLASVNSSIRLACCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRLLK 315 Query: 305 DVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSM 364 DVQ LQ+SL +L E SA+QI+ LE+QL+AK+ +++LEEKL+ Q+DYEE+K EL+ILK+M Sbjct: 316 DVQHLQSSLQELEEASANQIADLERQLTAKSEAIEKLEEKLQAQSDYEEIKTELSILKAM 375 Query: 365 EFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPG 424 + A S + Q AKP + LL+ K ++ L + S D + Sbjct: 376 KLASSTCSLPQGMAKPEDSLLIAKEAFFPTQKFLLEKPSLLASPEEDPSEDDSIKDSLGT 435 Query: 425 SLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALN--- 481 P P QLP PG + SP+ L PSL T F+L+ Sbjct: 436 EQSYPSPQQLPPPPGPE-------DPLSPSP------GQPLLGPSLGPDGTRTFSLSPFP 482 Query: 482 SLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSES 541 SL + + + EAG ++F Y ++ + P+ G P P+ Sbjct: 483 SLASGERLMMPPAAFKGEAGGL-LVFPPAFYGAKPPTAPATPAPGPEPLG-GPEPADGGG 540 Query: 542 AGSVSEG---EEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNK 598 G+ G E++DTAEIA QVKEQL+KHNIGQR+FGHYVLGLSQGSVSEILARPKPW K Sbjct: 541 GGAAGPGAEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRK 600 Query: 599 LTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITT 658 LTV+GKEPF KMKQFLSDEQN+LALR+IQ RQR G+IT Sbjct: 601 LTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQR----------------------GSITP 638 Query: 659 RIRASETGSDEAIKSILEQAKRELQVQKTAEP----AQPSSASGS---GNSDDAIRSILQ 711 RIR ETGSD+AIKSILEQAK+E++ QK EP A S A+G+ S+DAI+SIL+ Sbjct: 639 RIRTPETGSDDAIKSILEQAKKEIESQKGGEPKTSVAPLSIANGTTPASTSEDAIKSILE 698 Query: 712 QARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAP 771 QARREM+AQQ AL L P S PP P P Sbjct: 699 QARREMQAQQQAL---------------------LEMEVAPRGRSVPP------SPPERP 731 Query: 772 EAGASALPNPPALKKEAQDAPG-----LDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWS 826 ++ PAL K+ + + G L A Q ++R+VK+E+G +G + HW S Sbjct: 732 SLATASQNGAPALVKQEEGSGGPAQAPLPVLSPAAFVQSIIRKVKSEIGDAGYFDHHWAS 791 Query: 827 AVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAE 886 R AS + + + G SG G + PR + + + + AE Sbjct: 792 DRGLLSRPYASVSPSLSSSSSSGY---SGQPNGRAWPRGDEAPVPPEDEAA-----AGAE 843 Query: 887 SPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTI 946 ++ EL GA+ + LP P + + KP+VPPLTPEQYE+YMY+EVDT+ Sbjct: 844 DEPPRTGELKAEGATAEA---GARLPYYPAY-VPRTLKPTVPPLTPEQYELYMYREVDTL 899 Query: 947 ELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWL 1006 ELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWL Sbjct: 900 ELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWL 959 Query: 1007 NGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSES 1066 + +LGQ V GQQ G +S + P++S S P+P P SS+ Sbjct: 960 SDQLGQAV----GQQPG---------------ASQASPTEPRSSPSPPPSPTEPEKSSQE 1000 Query: 1067 VKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPEL 1126 SL+ +E+SK+++ PE S S + + + IQE+VAMSPEL Sbjct: 1001 PLSLS---------LESSKENQQPEGR----SSSSLSGKMYSGSQAPGGIQEIVAMSPEL 1047 Query: 1127 DTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQ 1186 DTY ITKRVKEVLTDNNLGQRLFGE+ILGLTQGSVSDLL+RPKPWHKLSLKGREPFVRMQ Sbjct: 1048 DTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQ 1107 Query: 1187 LWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQH---- 1242 LWLNDP+NVEKL DMK++EKKAY+KRR+ +S E P+ +E QPQ Sbjct: 1108 LWLNDPHNVEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSE-CPSPCLQPQDLSLL 1166 Query: 1243 QLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRE 1302 Q+KKPRVVLAPEEKEAL++AYQ +PYPS +TIE L+ QLNLKT+TVINWFHNYRSR+RRE Sbjct: 1167 QIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRRE 1226 Query: 1303 LFIEEIQ-------AGSQG---QAGASDSPSARSGRAAPSSEGDSCDGVEATEGP---GS 1349 + +E Q +G G + P+ +S + + + +E EGP + Sbjct: 1227 MLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENST 1286 Query: 1350 ADTEEPKSQGEAEREEVPRPAEQ---TEPPPSGT----PGPDDARDDD---HEGGPVEGP 1399 T + K+Q ++E++ AE+ ++P SG GP D ++G P P Sbjct: 1287 PLTTQDKAQVRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAP 1346 Query: 1400 GPL-------------------------PSPAS--ATATAAPAAPEDAATSAAAAPGEGP 1432 GPL P P S + + ++ + E + S +AA G Sbjct: 1347 GPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASESSRCSLEVSLNSPSAASSPGL 1406 Query: 1433 AAPSSAPPPSNSSSSSAP--RRPSSLQSLFGLPEAAGA--RDSRDNP---LRKKKAANLN 1485 S P S++ S +P P+ + S + AGA ++ NP R +K ANLN Sbjct: 1407 MMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLN 1466 Query: 1486 SIIHRLEKAASREEPIEWEF 1505 +II+R+E+AA+REE +EWEF Sbjct: 1467 NIIYRVERAANREEALEWEF 1486 >gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens] Length = 678 Score = 746 bits (1927), Expect = 0.0 Identities = 399/401 (99%), Positives = 401/401 (100%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 +L+RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL Sbjct: 19 QLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 78 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK Sbjct: 79 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 138 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT Sbjct: 139 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 198 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ Sbjct: 199 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 258 Query: 248 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 307 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ Sbjct: 259 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 318 Query: 308 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 367 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA Sbjct: 319 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 378 Query: 368 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 408 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG Sbjct: 379 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 419 Score = 35.0 bits (79), Expect = 0.55 Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 18/168 (10%) Query: 557 ARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSD 616 A ++EQL N ++ E+L R +L + +E + Q + D Sbjct: 261 AETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE----IAQLVED 316 Query: 617 EQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILE 676 Q + A + + REN +++L Q++ +N + + +++ ++ E Sbjct: 317 VQRLQASLT---KLRENSASQISQLEQQL-SAKNSTLKQLEEKLKG---------QADYE 363 Query: 677 QAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAAL 724 + K+EL + K+ E A PS +G+ ++ + +L + R ++++ AAL Sbjct: 364 EVKKELNILKSMEFA-PSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 410 >gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens] Length = 676 Score = 738 bits (1904), Expect = 0.0 Identities = 397/401 (99%), Positives = 399/401 (99%), Gaps = 2/401 (0%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 +L+RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL Sbjct: 19 QLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 78 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK Sbjct: 79 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 138 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT Sbjct: 139 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 198 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ Sbjct: 199 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 258 Query: 248 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 307 REAETLREQLSSANHSLQLASQIQKAPDV AIEVLTRSSLEVELAAKEREIAQLVEDVQ Sbjct: 259 REAETLREQLSSANHSLQLASQIQKAPDV--AIEVLTRSSLEVELAAKEREIAQLVEDVQ 316 Query: 308 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 367 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA Sbjct: 317 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 376 Query: 368 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 408 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG Sbjct: 377 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417 Score = 33.5 bits (75), Expect = 1.6 Identities = 30/137 (21%), Positives = 67/137 (48%), Gaps = 18/137 (13%) Query: 588 EILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPK 647 E+L R +L + +E + Q + D Q + A + + REN +++L Q++ Sbjct: 290 EVLTRSSLEVELAAKERE----IAQLVEDVQRLQASLT---KLRENSASQISQLEQQL-S 341 Query: 648 RRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIR 707 +N + + +++ ++ E+ K+EL + K+ E A PS +G+ ++ + Sbjct: 342 AKNSTLKQLEEKLKG---------QADYEEVKKELNILKSMEFA-PSEGAGTQDAAKPLE 391 Query: 708 SILQQARREMEAQQAAL 724 +L + R ++++ AAL Sbjct: 392 VLLLEKNRSLQSENAAL 408 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 86.7 bits (213), Expect = 2e-16 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 +L++ +A A + + +E+SR R+ E+ R + R++ +GE+ AL Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1478 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114 R++EAEA + A L +Q+Q + QR E E Sbjct: 1479 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529 Query: 115 -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 Q+ + LEE + E + + +A E+ R+ + L+ + E + K + FA Sbjct: 1530 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1586 Query: 174 EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229 EK ER LQE ++ EEAE + Q Q E+ R E + E KA+E Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1641 Query: 230 EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258 + E Q+ +AQ EAE +E QL+ Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1701 Query: 259 SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315 +LA++ I+ + EQ + R LE ELA +RE A + Q L+A L K Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1759 Query: 316 LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360 +R E S S + +Q+L A+ ++L EE + +A EE K++ + Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819 Query: 361 LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412 + + + A +E + A E L+ + ++EN LR D + RR Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879 Query: 413 KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467 + + + R L S+L R G Q L+ Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1931 Query: 468 PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524 S A+ GK L L R + SK E + ++ +Q Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991 Query: 525 QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583 +S A + + ++ E E + E AR+++E+ + + Q L L+Q Sbjct: 1992 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2040 Query: 584 GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643 + + L + + V+ KE +++Q L EQ++L Q ++ R + Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2091 Query: 644 EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703 E + R +E R E ++ +S EQA+ Q Q AE + + + Sbjct: 2092 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150 Query: 704 DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748 A ++ L+Q A EME + + L+Q + ++T L +L T Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198 Score = 67.4 bits (163), Expect = 1e-10 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73 DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q + R +E Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1201 Query: 74 AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127 E L Y+ D LG LQ +R I+ ++Q +RE L + Sbjct: 1202 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1253 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 E++ EK+ E ++ K I K+ +LQ Sbjct: 1254 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1292 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 + + K +Q+ E E DL+T Y E TT + I+ I L R + +A+ Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352 Query: 248 REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301 ++ RE+L+ +L+ Q+ KA +A E+ R ++ E+ +E Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1410 Query: 302 LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356 + + +Q L +LR++S ++I +Q A + ++EE+++ Q + E ++ Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470 Query: 357 ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412 EL L++ E A ++ Q+ A+ L R +Q E+ R + +L+ + Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1523 Query: 413 KGKDQPESRR 422 + + E +R Sbjct: 1524 EAEAAREKQR 1533 Score = 63.9 bits (154), Expect = 1e-09 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65 R K +++ T L + +E++ + L E+ + K E R+ QV L S + +++ Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125 LSK EA + R D + + LQ + +++ + E +L +E Sbjct: 2239 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290 Query: 126 NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 + + AE + + + K LKEK++ ++ + +AE L+++++L E+ R+LQ Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2347 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 E + +L E + Q Q LE R ++ +A+A+ +++ + ++ RA Sbjct: 2348 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2396 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 RAE +A+ R+Q L ELA +E+ Sbjct: 2397 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2430 Query: 301 QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 ++QR Q+ +LRE I++LE++ +EKL+ +A ++K E Sbjct: 2431 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2475 Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418 E E Q + + LL++ R ++ E A L D A++ ++Q Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535 Query: 419 ESRR 422 ++ Sbjct: 2536 RQQQ 2539 Score = 60.1 bits (144), Expect = 2e-08 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66 +A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++ Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013 Query: 67 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125 L + +EA +RL + + A +QLQL + ++ E + +++ Sbjct: 2014 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185 +E + QE +++ +++R + + AE A E + + + A+ R+++E + Sbjct: 2062 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2117 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238 S E+A+ + Q+ Q A EK R E + + A + + ++E+ Sbjct: 2118 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176 Query: 239 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297 Q+A+V Q E TLR QL +H L + + E RS +E EL + Sbjct: 2177 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235 Query: 298 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326 ++ +L ++ QR LQ K+++ A+++ Q Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295 Query: 327 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383 L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + + Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355 Query: 384 LLLEKNRSLQSENAALRISNSDLSGSARR 412 L E+ + Q A R ++S A R Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAER 2384 Score = 48.1 bits (113), Expect = 6e-05 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%) Query: 5 AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58 A A L ++ A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386 Query: 59 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115 E+ R++E F K+ ++ + + +L Q ++ + + +I+ + Sbjct: 2387 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443 Query: 116 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163 ++LRE + E +E E QE + LK + + Q + ET AL+ Sbjct: 2444 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502 Query: 164 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200 K Q+L+ + +++++++ + + +EEA + Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562 Query: 201 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260 + + + + EL L+ + ++ A+E + + L+ ++ A +E + +A Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622 Query: 261 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318 +L P E E + L +++A+ + A ++ E++QRL T + E Sbjct: 2623 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681 Query: 319 NSASQISQ--LEQQLSAKNSTLKQLEEKL 345 + + + L+ + S LK EKL Sbjct: 2682 LARREDVRHYLQGRSSIAGLLLKATNEKL 2710 Score = 32.3 bits (72), Expect = 3.5 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%) Query: 114 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 E QK + +E K A + + + AL E A T+ E E L Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1074 Query: 174 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233 E+ R L + KL+ ++ Q A E R LK + A E+E Sbjct: 1075 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1129 Query: 234 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293 L++ +AE Q + LR++L A ++ ++Q+ +VE+ Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1175 Query: 294 AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346 +AQL+E Q + A T +R+ Q+ + L A ++ +E+++ Sbjct: 1176 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234 Query: 347 ------GQADYEEVKKELNILKSME 365 QA E++++E +L+ +E Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIE 1259 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 86.7 bits (213), Expect = 2e-16 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 +L++ +A A + + +E+SR R+ E+ R + R++ +GE+ AL Sbjct: 1428 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1482 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114 R++EAEA + A L +Q+Q + QR E E Sbjct: 1483 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1533 Query: 115 -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 Q+ + LEE + E + + +A E+ R+ + L+ + E + K + FA Sbjct: 1534 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1590 Query: 174 EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229 EK ER LQE ++ EEAE + Q Q E+ R E + E KA+E Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1645 Query: 230 EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258 + E Q+ +AQ EAE +E QL+ Sbjct: 1646 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1705 Query: 259 SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315 +LA++ I+ + EQ + R LE ELA +RE A + Q L+A L K Sbjct: 1706 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1763 Query: 316 LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360 +R E S S + +Q+L A+ ++L EE + +A EE K++ + Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1823 Query: 361 LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412 + + + A +E + A E L+ + ++EN LR D + RR Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1883 Query: 413 KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467 + + + R L S+L R G Q L+ Sbjct: 1884 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1935 Query: 468 PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524 S A+ GK L L R + SK E + ++ +Q Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1995 Query: 525 QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583 +S A + + ++ E E + E AR+++E+ + + Q L L+Q Sbjct: 1996 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2044 Query: 584 GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643 + + L + + V+ KE +++Q L EQ++L Q ++ R + Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2095 Query: 644 EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703 E + R +E R E ++ +S EQA+ Q Q AE + + + Sbjct: 2096 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2154 Query: 704 DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748 A ++ L+Q A EME + + L+Q + ++T L +L T Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202 Score = 67.4 bits (163), Expect = 1e-10 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73 DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q + R +E Sbjct: 1151 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1205 Query: 74 AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127 E L Y+ D LG LQ +R I+ ++Q +RE L + Sbjct: 1206 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1257 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 E++ EK+ E ++ K I K+ +LQ Sbjct: 1258 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1296 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 + + K +Q+ E E DL+T Y E TT + I+ I L R + +A+ Sbjct: 1297 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1356 Query: 248 REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301 ++ RE+L+ +L+ Q+ KA +A E+ R ++ E+ +E Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1414 Query: 302 LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356 + + +Q L +LR++S ++I +Q A + ++EE+++ Q + E ++ Sbjct: 1415 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474 Query: 357 ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412 EL L++ E A ++ Q+ A+ L R +Q E+ R + +L+ + Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1527 Query: 413 KGKDQPESRR 422 + + E +R Sbjct: 1528 EAEAAREKQR 1537 Score = 63.9 bits (154), Expect = 1e-09 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65 R K +++ T L + +E++ + L E+ + K E R+ QV L S + +++ Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125 LSK EA + R D + + LQ + +++ + E +L +E Sbjct: 2243 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294 Query: 126 NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 + + AE + + + K LKEK++ ++ + +AE L+++++L E+ R+LQ Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2351 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 E + +L E + Q Q LE R ++ +A+A+ +++ + ++ RA Sbjct: 2352 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2400 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 RAE +A+ R+Q L ELA +E+ Sbjct: 2401 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2434 Query: 301 QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 ++QR Q+ +LRE I++LE++ +EKL+ +A ++K E Sbjct: 2435 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2479 Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418 E E Q + + LL++ R ++ E A L D A++ ++Q Sbjct: 2480 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2539 Query: 419 ESRR 422 ++ Sbjct: 2540 RQQQ 2543 Score = 60.1 bits (144), Expect = 2e-08 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66 +A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++ Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017 Query: 67 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125 L + +EA +RL + + A +QLQL + ++ E + +++ Sbjct: 2018 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185 +E + QE +++ +++R + + AE A E + + + A+ R+++E + Sbjct: 2066 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2121 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238 S E+A+ + Q+ Q A EK R E + + A + + ++E+ Sbjct: 2122 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180 Query: 239 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297 Q+A+V Q E TLR QL +H L + + E RS +E EL + Sbjct: 2181 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2239 Query: 298 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326 ++ +L ++ QR LQ K+++ A+++ Q Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2299 Query: 327 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383 L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + + Sbjct: 2300 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2359 Query: 384 LLLEKNRSLQSENAALRISNSDLSGSARR 412 L E+ + Q A R ++S A R Sbjct: 2360 QLAEETQGFQRTLEAERQRQLEMSAEAER 2388 Score = 48.1 bits (113), Expect = 6e-05 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%) Query: 5 AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58 A A L ++ A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK Sbjct: 2331 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390 Query: 59 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115 E+ R++E F K+ ++ + + +L Q ++ + + +I+ + Sbjct: 2391 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447 Query: 116 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163 ++LRE + E +E E QE + LK + + Q + ET AL+ Sbjct: 2448 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506 Query: 164 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200 K Q+L+ + +++++++ + + +EEA + Sbjct: 2507 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2566 Query: 201 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260 + + + + EL L+ + ++ A+E + + L+ ++ A +E + +A Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2626 Query: 261 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318 +L P E E + L +++A+ + A ++ E++QRL T + E Sbjct: 2627 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2685 Query: 319 NSASQISQ--LEQQLSAKNSTLKQLEEKL 345 + + + L+ + S LK EKL Sbjct: 2686 LARREDVRHYLQGRSSIAGLLLKATNEKL 2714 Score = 32.3 bits (72), Expect = 3.5 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%) Query: 114 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 E QK + +E K A + + + AL E A T+ E E L Sbjct: 1029 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1078 Query: 174 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233 E+ R L + KL+ ++ Q A E R LK + A E+E Sbjct: 1079 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1133 Query: 234 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293 L++ +AE Q + LR++L A ++ ++Q+ +VE+ Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1179 Query: 294 AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346 +AQL+E Q + A T +R+ Q+ + L A ++ +E+++ Sbjct: 1180 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238 Query: 347 ------GQADYEEVKKELNILKSME 365 QA E++++E +L+ +E Sbjct: 1239 AMPLADSQAVREQLRQEQALLEEIE 1263 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 86.7 bits (213), Expect = 2e-16 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 +L++ +A A + + +E+SR R+ E+ R + R++ +GE+ AL Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1478 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114 R++EAEA + A L +Q+Q + QR E E Sbjct: 1479 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529 Query: 115 -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 Q+ + LEE + E + + +A E+ R+ + L+ + E + K + FA Sbjct: 1530 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1586 Query: 174 EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229 EK ER LQE ++ EEAE + Q Q E+ R E + E KA+E Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1641 Query: 230 EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258 + E Q+ +AQ EAE +E QL+ Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1701 Query: 259 SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315 +LA++ I+ + EQ + R LE ELA +RE A + Q L+A L K Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1759 Query: 316 LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360 +R E S S + +Q+L A+ ++L EE + +A EE K++ + Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819 Query: 361 LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412 + + + A +E + A E L+ + ++EN LR D + RR Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879 Query: 413 KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467 + + + R L S+L R G Q L+ Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1931 Query: 468 PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524 S A+ GK L L R + SK E + ++ +Q Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991 Query: 525 QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583 +S A + + ++ E E + E AR+++E+ + + Q L L+Q Sbjct: 1992 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2040 Query: 584 GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643 + + L + + V+ KE +++Q L EQ++L Q ++ R + Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2091 Query: 644 EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703 E + R +E R E ++ +S EQA+ Q Q AE + + + Sbjct: 2092 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150 Query: 704 DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748 A ++ L+Q A EME + + L+Q + ++T L +L T Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198 Score = 67.4 bits (163), Expect = 1e-10 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73 DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q + R +E Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1201 Query: 74 AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127 E L Y+ D LG LQ +R I+ ++Q +RE L + Sbjct: 1202 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1253 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 E++ EK+ E ++ K I K+ +LQ Sbjct: 1254 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1292 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 + + K +Q+ E E DL+T Y E TT + I+ I L R + +A+ Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352 Query: 248 REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301 ++ RE+L+ +L+ Q+ KA +A E+ R ++ E+ +E Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1410 Query: 302 LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356 + + +Q L +LR++S ++I +Q A + ++EE+++ Q + E ++ Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470 Query: 357 ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412 EL L++ E A ++ Q+ A+ L R +Q E+ R + +L+ + Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1523 Query: 413 KGKDQPESRR 422 + + E +R Sbjct: 1524 EAEAAREKQR 1533 Score = 63.9 bits (154), Expect = 1e-09 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65 R K +++ T L + +E++ + L E+ + K E R+ QV L S + +++ Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125 LSK EA + R D + + LQ + +++ + E +L +E Sbjct: 2239 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290 Query: 126 NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 + + AE + + + K LKEK++ ++ + +AE L+++++L E+ R+LQ Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2347 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 E + +L E + Q Q LE R ++ +A+A+ +++ + ++ RA Sbjct: 2348 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2396 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 RAE +A+ R+Q L ELA +E+ Sbjct: 2397 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2430 Query: 301 QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 ++QR Q+ +LRE I++LE++ +EKL+ +A ++K E Sbjct: 2431 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2475 Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418 E E Q + + LL++ R ++ E A L D A++ ++Q Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535 Query: 419 ESRR 422 ++ Sbjct: 2536 RQQQ 2539 Score = 60.1 bits (144), Expect = 2e-08 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66 +A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++ Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013 Query: 67 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125 L + +EA +RL + + A +QLQL + ++ E + +++ Sbjct: 2014 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185 +E + QE +++ +++R + + AE A E + + + A+ R+++E + Sbjct: 2062 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2117 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238 S E+A+ + Q+ Q A EK R E + + A + + ++E+ Sbjct: 2118 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176 Query: 239 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297 Q+A+V Q E TLR QL +H L + + E RS +E EL + Sbjct: 2177 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235 Query: 298 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326 ++ +L ++ QR LQ K+++ A+++ Q Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295 Query: 327 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383 L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + + Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355 Query: 384 LLLEKNRSLQSENAALRISNSDLSGSARR 412 L E+ + Q A R ++S A R Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAER 2384 Score = 48.1 bits (113), Expect = 6e-05 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%) Query: 5 AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58 A A L ++ A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386 Query: 59 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115 E+ R++E F K+ ++ + + +L Q ++ + + +I+ + Sbjct: 2387 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443 Query: 116 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163 ++LRE + E +E E QE + LK + + Q + ET AL+ Sbjct: 2444 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502 Query: 164 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200 K Q+L+ + +++++++ + + +EEA + Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562 Query: 201 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260 + + + + EL L+ + ++ A+E + + L+ ++ A +E + +A Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622 Query: 261 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318 +L P E E + L +++A+ + A ++ E++QRL T + E Sbjct: 2623 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681 Query: 319 NSASQISQ--LEQQLSAKNSTLKQLEEKL 345 + + + L+ + S LK EKL Sbjct: 2682 LARREDVRHYLQGRSSIAGLLLKATNEKL 2710 Score = 32.3 bits (72), Expect = 3.5 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%) Query: 114 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 E QK + +E K A + + + AL E A T+ E E L Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1074 Query: 174 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233 E+ R L + KL+ ++ Q A E R LK + A E+E Sbjct: 1075 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1129 Query: 234 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293 L++ +AE Q + LR++L A ++ ++Q+ +VE+ Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1175 Query: 294 AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346 +AQL+E Q + A T +R+ Q+ + L A ++ +E+++ Sbjct: 1176 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234 Query: 347 ------GQADYEEVKKELNILKSME 365 QA E++++E +L+ +E Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIE 1259 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 86.7 bits (213), Expect = 2e-16 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 +L++ +A A + + +E+SR R+ E+ R + R++ +GE+ AL Sbjct: 1392 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1446 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114 R++EAEA + A L +Q+Q + QR E E Sbjct: 1447 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1497 Query: 115 -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 Q+ + LEE + E + + +A E+ R+ + L+ + E + K + FA Sbjct: 1498 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1554 Query: 174 EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229 EK ER LQE ++ EEAE + Q Q E+ R E + E KA+E Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1609 Query: 230 EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258 + E Q+ +AQ EAE +E QL+ Sbjct: 1610 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1669 Query: 259 SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315 +LA++ I+ + EQ + R LE ELA +RE A + Q L+A L K Sbjct: 1670 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1727 Query: 316 LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360 +R E S S + +Q+L A+ ++L EE + +A EE K++ + Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1787 Query: 361 LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412 + + + A +E + A E L+ + ++EN LR D + RR Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1847 Query: 413 KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467 + + + R L S+L R G Q L+ Sbjct: 1848 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1899 Query: 468 PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524 S A+ GK L L R + SK E + ++ +Q Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1959 Query: 525 QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583 +S A + + ++ E E + E AR+++E+ + + Q L L+Q Sbjct: 1960 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2008 Query: 584 GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643 + + L + + V+ KE +++Q L EQ++L Q ++ R + Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2059 Query: 644 EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703 E + R +E R E ++ +S EQA+ Q Q AE + + + Sbjct: 2060 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2118 Query: 704 DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748 A ++ L+Q A EME + + L+Q + ++T L +L T Sbjct: 2119 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166 Score = 67.4 bits (163), Expect = 1e-10 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73 DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q + R +E Sbjct: 1115 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1169 Query: 74 AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127 E L Y+ D LG LQ +R I+ ++Q +RE L + Sbjct: 1170 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1221 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 E++ EK+ E ++ K I K+ +LQ Sbjct: 1222 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1260 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 + + K +Q+ E E DL+T Y E TT + I+ I L R + +A+ Sbjct: 1261 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1320 Query: 248 REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301 ++ RE+L+ +L+ Q+ KA +A E+ R ++ E+ +E Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1378 Query: 302 LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356 + + +Q L +LR++S ++I +Q A + ++EE+++ Q + E ++ Sbjct: 1379 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1438 Query: 357 ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412 EL L++ E A ++ Q+ A+ L R +Q E+ R + +L+ + Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1491 Query: 413 KGKDQPESRR 422 + + E +R Sbjct: 1492 EAEAAREKQR 1501 Score = 63.9 bits (154), Expect = 1e-09 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65 R K +++ T L + +E++ + L E+ + K E R+ QV L S + +++ Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125 LSK EA + R D + + LQ + +++ + E +L +E Sbjct: 2207 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258 Query: 126 NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 + + AE + + + K LKEK++ ++ + +AE L+++++L E+ R+LQ Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2315 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 E + +L E + Q Q LE R ++ +A+A+ +++ + ++ RA Sbjct: 2316 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2364 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 RAE +A+ R+Q L ELA +E+ Sbjct: 2365 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2398 Query: 301 QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 ++QR Q+ +LRE I++LE++ +EKL+ +A ++K E Sbjct: 2399 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2443 Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418 E E Q + + LL++ R ++ E A L D A++ ++Q Sbjct: 2444 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2503 Query: 419 ESRR 422 ++ Sbjct: 2504 RQQQ 2507 Score = 60.1 bits (144), Expect = 2e-08 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66 +A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++ Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981 Query: 67 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125 L + +EA +RL + + A +QLQL + ++ E + +++ Sbjct: 1982 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185 +E + QE +++ +++R + + AE A E + + + A+ R+++E + Sbjct: 2030 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2085 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238 S E+A+ + Q+ Q A EK R E + + A + + ++E+ Sbjct: 2086 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144 Query: 239 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297 Q+A+V Q E TLR QL +H L + + E RS +E EL + Sbjct: 2145 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2203 Query: 298 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326 ++ +L ++ QR LQ K+++ A+++ Q Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2263 Query: 327 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383 L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + + Sbjct: 2264 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2323 Query: 384 LLLEKNRSLQSENAALRISNSDLSGSARR 412 L E+ + Q A R ++S A R Sbjct: 2324 QLAEETQGFQRTLEAERQRQLEMSAEAER 2352 Score = 48.1 bits (113), Expect = 6e-05 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%) Query: 5 AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58 A A L ++ A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK Sbjct: 2295 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354 Query: 59 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115 E+ R++E F K+ ++ + + +L Q ++ + + +I+ + Sbjct: 2355 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2411 Query: 116 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163 ++LRE + E +E E QE + LK + + Q + ET AL+ Sbjct: 2412 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470 Query: 164 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200 K Q+L+ + +++++++ + + +EEA + Sbjct: 2471 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2530 Query: 201 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260 + + + + EL L+ + ++ A+E + + L+ ++ A +E + +A Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2590 Query: 261 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318 +L P E E + L +++A+ + A ++ E++QRL T + E Sbjct: 2591 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2649 Query: 319 NSASQISQ--LEQQLSAKNSTLKQLEEKL 345 + + + L+ + S LK EKL Sbjct: 2650 LARREDVRHYLQGRSSIAGLLLKATNEKL 2678 Score = 32.3 bits (72), Expect = 3.5 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%) Query: 114 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 E QK + +E K A + + + AL E A T+ E E L Sbjct: 993 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1042 Query: 174 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233 E+ R L + KL+ ++ Q A E R LK + A E+E Sbjct: 1043 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1097 Query: 234 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293 L++ +AE Q + LR++L A ++ ++Q+ +VE+ Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1143 Query: 294 AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346 +AQL+E Q + A T +R+ Q+ + L A ++ +E+++ Sbjct: 1144 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202 Query: 347 ------GQADYEEVKKELNILKSME 365 QA E++++E +L+ +E Sbjct: 1203 AMPLADSQAVREQLRQEQALLEEIE 1227 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 86.7 bits (213), Expect = 2e-16 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 +L++ +A A + + +E+SR R+ E+ R + R++ +GE+ AL Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1615 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114 R++EAEA + A L +Q+Q + QR E E Sbjct: 1616 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1666 Query: 115 -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 Q+ + LEE + E + + +A E+ R+ + L+ + E + K + FA Sbjct: 1667 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1723 Query: 174 EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229 EK ER LQE ++ EEAE + Q Q E+ R E + E KA+E Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1778 Query: 230 EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258 + E Q+ +AQ EAE +E QL+ Sbjct: 1779 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1838 Query: 259 SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315 +LA++ I+ + EQ + R LE ELA +RE A + Q L+A L K Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1896 Query: 316 LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360 +R E S S + +Q+L A+ ++L EE + +A EE K++ + Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1956 Query: 361 LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412 + + + A +E + A E L+ + ++EN LR D + RR Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 2016 Query: 413 KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467 + + + R L S+L R G Q L+ Sbjct: 2017 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 2068 Query: 468 PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524 S A+ GK L L R + SK E + ++ +Q Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2128 Query: 525 QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583 +S A + + ++ E E + E AR+++E+ + + Q L L+Q Sbjct: 2129 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2177 Query: 584 GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643 + + L + + V+ KE +++Q L EQ++L Q ++ R + Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2228 Query: 644 EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703 E + R +E R E ++ +S EQA+ Q Q AE + + + Sbjct: 2229 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2287 Query: 704 DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748 A ++ L+Q A EME + + L+Q + ++T L +L T Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335 Score = 67.4 bits (163), Expect = 1e-10 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73 DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q + R +E Sbjct: 1284 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1338 Query: 74 AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127 E L Y+ D LG LQ +R I+ ++Q +RE L + Sbjct: 1339 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1390 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 E++ EK+ E ++ K I K+ +LQ Sbjct: 1391 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1429 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 + + K +Q+ E E DL+T Y E TT + I+ I L R + +A+ Sbjct: 1430 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489 Query: 248 REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301 ++ RE+L+ +L+ Q+ KA +A E+ R ++ E+ +E Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1547 Query: 302 LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356 + + +Q L +LR++S ++I +Q A + ++EE+++ Q + E ++ Sbjct: 1548 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1607 Query: 357 ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412 EL L++ E A ++ Q+ A+ L R +Q E+ R + +L+ + Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1660 Query: 413 KGKDQPESRR 422 + + E +R Sbjct: 1661 EAEAAREKQR 1670 Score = 63.9 bits (154), Expect = 1e-09 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65 R K +++ T L + +E++ + L E+ + K E R+ QV L S + +++ Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125 LSK EA + R D + + LQ + +++ + E +L +E Sbjct: 2376 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427 Query: 126 NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 + + AE + + + K LKEK++ ++ + +AE L+++++L E+ R+LQ Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2484 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 E + +L E + Q Q LE R ++ +A+A+ +++ + ++ RA Sbjct: 2485 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2533 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 RAE +A+ R+Q L ELA +E+ Sbjct: 2534 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2567 Query: 301 QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 ++QR Q+ +LRE I++LE++ +EKL+ +A ++K E Sbjct: 2568 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2612 Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418 E E Q + + LL++ R ++ E A L D A++ ++Q Sbjct: 2613 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2672 Query: 419 ESRR 422 ++ Sbjct: 2673 RQQQ 2676 Score = 60.1 bits (144), Expect = 2e-08 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66 +A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++ Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150 Query: 67 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125 L + +EA +RL + + A +QLQL + ++ E + +++ Sbjct: 2151 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185 +E + QE +++ +++R + + AE A E + + + A+ R+++E + Sbjct: 2199 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2254 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238 S E+A+ + Q+ Q A EK R E + + A + + ++E+ Sbjct: 2255 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313 Query: 239 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297 Q+A+V Q E TLR QL +H L + + E RS +E EL + Sbjct: 2314 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2372 Query: 298 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326 ++ +L ++ QR LQ K+++ A+++ Q Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2432 Query: 327 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383 L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + + Sbjct: 2433 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2492 Query: 384 LLLEKNRSLQSENAALRISNSDLSGSARR 412 L E+ + Q A R ++S A R Sbjct: 2493 QLAEETQGFQRTLEAERQRQLEMSAEAER 2521 Score = 48.1 bits (113), Expect = 6e-05 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%) Query: 5 AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58 A A L ++ A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK Sbjct: 2464 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523 Query: 59 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115 E+ R++E F K+ ++ + + +L Q ++ + + +I+ + Sbjct: 2524 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580 Query: 116 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163 ++LRE + E +E E QE + LK + + Q + ET AL+ Sbjct: 2581 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639 Query: 164 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200 K Q+L+ + +++++++ + + +EEA + Sbjct: 2640 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2699 Query: 201 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260 + + + + EL L+ + ++ A+E + + L+ ++ A +E + +A Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2759 Query: 261 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318 +L P E E + L +++A+ + A ++ E++QRL T + E Sbjct: 2760 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2818 Query: 319 NSASQISQ--LEQQLSAKNSTLKQLEEKL 345 + + + L+ + S LK EKL Sbjct: 2819 LARREDVRHYLQGRSSIAGLLLKATNEKL 2847 Score = 32.3 bits (72), Expect = 3.5 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%) Query: 114 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 E QK + +E K A + + + AL E A T+ E E L Sbjct: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1211 Query: 174 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233 E+ R L + KL+ ++ Q A E R LK + A E+E Sbjct: 1212 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1266 Query: 234 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293 L++ +AE Q + LR++L A ++ ++Q+ +VE+ Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1312 Query: 294 AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346 +AQL+E Q + A T +R+ Q+ + L A ++ +E+++ Sbjct: 1313 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371 Query: 347 ------GQADYEEVKKELNILKSME 365 QA E++++E +L+ +E Sbjct: 1372 AMPLADSQAVREQLRQEQALLEEIE 1396 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 86.7 bits (213), Expect = 2e-16 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 +L++ +A A + + +E+SR R+ E+ R + R++ +GE+ AL Sbjct: 1402 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1456 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114 R++EAEA + A L +Q+Q + QR E E Sbjct: 1457 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507 Query: 115 -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 Q+ + LEE + E + + +A E+ R+ + L+ + E + K + FA Sbjct: 1508 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1564 Query: 174 EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229 EK ER LQE ++ EEAE + Q Q E+ R E + E KA+E Sbjct: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1619 Query: 230 EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258 + E Q+ +AQ EAE +E QL+ Sbjct: 1620 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1679 Query: 259 SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315 +LA++ I+ + EQ + R LE ELA +RE A + Q L+A L K Sbjct: 1680 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1737 Query: 316 LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360 +R E S S + +Q+L A+ ++L EE + +A EE K++ + Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1797 Query: 361 LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412 + + + A +E + A E L+ + ++EN LR D + RR Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1857 Query: 413 KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467 + + + R L S+L R G Q L+ Sbjct: 1858 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1909 Query: 468 PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524 S A+ GK L L R + SK E + ++ +Q Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1969 Query: 525 QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583 +S A + + ++ E E + E AR+++E+ + + Q L L+Q Sbjct: 1970 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2018 Query: 584 GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643 + + L + + V+ KE +++Q L EQ++L Q ++ R + Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2069 Query: 644 EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703 E + R +E R E ++ +S EQA+ Q Q AE + + + Sbjct: 2070 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2128 Query: 704 DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748 A ++ L+Q A EME + + L+Q + ++T L +L T Sbjct: 2129 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176 Score = 67.4 bits (163), Expect = 1e-10 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73 DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q + R +E Sbjct: 1125 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1179 Query: 74 AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127 E L Y+ D LG LQ +R I+ ++Q +RE L + Sbjct: 1180 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1231 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 E++ EK+ E ++ K I K+ +LQ Sbjct: 1232 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1270 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 + + K +Q+ E E DL+T Y E TT + I+ I L R + +A+ Sbjct: 1271 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1330 Query: 248 REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301 ++ RE+L+ +L+ Q+ KA +A E+ R ++ E+ +E Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1388 Query: 302 LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356 + + +Q L +LR++S ++I +Q A + ++EE+++ Q + E ++ Sbjct: 1389 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1448 Query: 357 ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412 EL L++ E A ++ Q+ A+ L R +Q E+ R + +L+ + Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1501 Query: 413 KGKDQPESRR 422 + + E +R Sbjct: 1502 EAEAAREKQR 1511 Score = 63.9 bits (154), Expect = 1e-09 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65 R K +++ T L + +E++ + L E+ + K E R+ QV L S + +++ Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125 LSK EA + R D + + LQ + +++ + E +L +E Sbjct: 2217 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268 Query: 126 NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 + + AE + + + K LKEK++ ++ + +AE L+++++L E+ R+LQ Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2325 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 E + +L E + Q Q LE R ++ +A+A+ +++ + ++ RA Sbjct: 2326 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2374 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 RAE +A+ R+Q L ELA +E+ Sbjct: 2375 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2408 Query: 301 QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 ++QR Q+ +LRE I++LE++ +EKL+ +A ++K E Sbjct: 2409 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2453 Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418 E E Q + + LL++ R ++ E A L D A++ ++Q Sbjct: 2454 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2513 Query: 419 ESRR 422 ++ Sbjct: 2514 RQQQ 2517 Score = 60.1 bits (144), Expect = 2e-08 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66 +A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++ Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991 Query: 67 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125 L + +EA +RL + + A +QLQL + ++ E + +++ Sbjct: 1992 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185 +E + QE +++ +++R + + AE A E + + + A+ R+++E + Sbjct: 2040 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2095 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238 S E+A+ + Q+ Q A EK R E + + A + + ++E+ Sbjct: 2096 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154 Query: 239 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297 Q+A+V Q E TLR QL +H L + + E RS +E EL + Sbjct: 2155 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2213 Query: 298 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326 ++ +L ++ QR LQ K+++ A+++ Q Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2273 Query: 327 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383 L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + + Sbjct: 2274 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2333 Query: 384 LLLEKNRSLQSENAALRISNSDLSGSARR 412 L E+ + Q A R ++S A R Sbjct: 2334 QLAEETQGFQRTLEAERQRQLEMSAEAER 2362 Score = 48.1 bits (113), Expect = 6e-05 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%) Query: 5 AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58 A A L ++ A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK Sbjct: 2305 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364 Query: 59 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115 E+ R++E F K+ ++ + + +L Q ++ + + +I+ + Sbjct: 2365 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2421 Query: 116 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163 ++LRE + E +E E QE + LK + + Q + ET AL+ Sbjct: 2422 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480 Query: 164 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200 K Q+L+ + +++++++ + + +EEA + Sbjct: 2481 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2540 Query: 201 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260 + + + + EL L+ + ++ A+E + + L+ ++ A +E + +A Sbjct: 2541 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2600 Query: 261 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318 +L P E E + L +++A+ + A ++ E++QRL T + E Sbjct: 2601 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2659 Query: 319 NSASQISQ--LEQQLSAKNSTLKQLEEKL 345 + + + L+ + S LK EKL Sbjct: 2660 LARREDVRHYLQGRSSIAGLLLKATNEKL 2688 Score = 32.3 bits (72), Expect = 3.5 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%) Query: 114 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 E QK + +E K A + + + AL E A T+ E E L Sbjct: 1003 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1052 Query: 174 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233 E+ R L + KL+ ++ Q A E R LK + A E+E Sbjct: 1053 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1107 Query: 234 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293 L++ +AE Q + LR++L A ++ ++Q+ +VE+ Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1153 Query: 294 AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346 +AQL+E Q + A T +R+ Q+ + L A ++ +E+++ Sbjct: 1154 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212 Query: 347 ------GQADYEEVKKELNILKSME 365 QA E++++E +L+ +E Sbjct: 1213 AMPLADSQAVREQLRQEQALLEEIE 1237 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 86.7 bits (213), Expect = 2e-16 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 +L++ +A A + + +E+SR R+ E+ R + R++ +GE+ AL Sbjct: 1410 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1464 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114 R++EAEA + A L +Q+Q + QR E E Sbjct: 1465 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1515 Query: 115 -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 Q+ + LEE + E + + +A E+ R+ + L+ + E + K + FA Sbjct: 1516 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1572 Query: 174 EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229 EK ER LQE ++ EEAE + Q Q E+ R E + E KA+E Sbjct: 1573 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1627 Query: 230 EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258 + E Q+ +AQ EAE +E QL+ Sbjct: 1628 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1687 Query: 259 SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315 +LA++ I+ + EQ + R LE ELA +RE A + Q L+A L K Sbjct: 1688 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1745 Query: 316 LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360 +R E S S + +Q+L A+ ++L EE + +A EE K++ + Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1805 Query: 361 LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412 + + + A +E + A E L+ + ++EN LR D + RR Sbjct: 1806 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1865 Query: 413 KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467 + + + R L S+L R G Q L+ Sbjct: 1866 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1917 Query: 468 PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524 S A+ GK L L R + SK E + ++ +Q Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1977 Query: 525 QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583 +S A + + ++ E E + E AR+++E+ + + Q L L+Q Sbjct: 1978 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2026 Query: 584 GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643 + + L + + V+ KE +++Q L EQ++L Q ++ R + Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2077 Query: 644 EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703 E + R +E R E ++ +S EQA+ Q Q AE + + + Sbjct: 2078 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2136 Query: 704 DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748 A ++ L+Q A EME + + L+Q + ++T L +L T Sbjct: 2137 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2184 Score = 67.4 bits (163), Expect = 1e-10 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73 DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q + R +E Sbjct: 1133 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1187 Query: 74 AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127 E L Y+ D LG LQ +R I+ ++Q +RE L + Sbjct: 1188 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1239 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 E++ EK+ E ++ K I K+ +LQ Sbjct: 1240 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1278 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 + + K +Q+ E E DL+T Y E TT + I+ I L R + +A+ Sbjct: 1279 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338 Query: 248 REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301 ++ RE+L+ +L+ Q+ KA +A E+ R ++ E+ +E Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1396 Query: 302 LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356 + + +Q L +LR++S ++I +Q A + ++EE+++ Q + E ++ Sbjct: 1397 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1456 Query: 357 ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412 EL L++ E A ++ Q+ A+ L R +Q E+ R + +L+ + Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1509 Query: 413 KGKDQPESRR 422 + + E +R Sbjct: 1510 EAEAAREKQR 1519 Score = 63.9 bits (154), Expect = 1e-09 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65 R K +++ T L + +E++ + L E+ + K E R+ QV L S + +++ Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2224 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125 LSK EA + R D + + LQ + +++ + E +L +E Sbjct: 2225 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276 Query: 126 NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 + + AE + + + K LKEK++ ++ + +AE L+++++L E+ R+LQ Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2333 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 E + +L E + Q Q LE R ++ +A+A+ +++ + ++ RA Sbjct: 2334 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2382 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 RAE +A+ R+Q L ELA +E+ Sbjct: 2383 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2416 Query: 301 QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 ++QR Q+ +LRE I++LE++ +EKL+ +A ++K E Sbjct: 2417 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2461 Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418 E E Q + + LL++ R ++ E A L D A++ ++Q Sbjct: 2462 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2521 Query: 419 ESRR 422 ++ Sbjct: 2522 RQQQ 2525 Score = 60.1 bits (144), Expect = 2e-08 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66 +A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++ Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999 Query: 67 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125 L + +EA +RL + + A +QLQL + ++ E + +++ Sbjct: 2000 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185 +E + QE +++ +++R + + AE A E + + + A+ R+++E + Sbjct: 2048 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2103 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238 S E+A+ + Q+ Q A EK R E + + A + + ++E+ Sbjct: 2104 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162 Query: 239 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297 Q+A+V Q E TLR QL +H L + + E RS +E EL + Sbjct: 2163 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2221 Query: 298 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326 ++ +L ++ QR LQ K+++ A+++ Q Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2281 Query: 327 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383 L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + + Sbjct: 2282 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2341 Query: 384 LLLEKNRSLQSENAALRISNSDLSGSARR 412 L E+ + Q A R ++S A R Sbjct: 2342 QLAEETQGFQRTLEAERQRQLEMSAEAER 2370 Score = 48.1 bits (113), Expect = 6e-05 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%) Query: 5 AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58 A A L ++ A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK Sbjct: 2313 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2372 Query: 59 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115 E+ R++E F K+ ++ + + +L Q ++ + + +I+ + Sbjct: 2373 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2429 Query: 116 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163 ++LRE + E +E E QE + LK + + Q + ET AL+ Sbjct: 2430 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2488 Query: 164 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200 K Q+L+ + +++++++ + + +EEA + Sbjct: 2489 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2548 Query: 201 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260 + + + + EL L+ + ++ A+E + + L+ ++ A +E + +A Sbjct: 2549 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2608 Query: 261 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318 +L P E E + L +++A+ + A ++ E++QRL T + E Sbjct: 2609 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2667 Query: 319 NSASQISQ--LEQQLSAKNSTLKQLEEKL 345 + + + L+ + S LK EKL Sbjct: 2668 LARREDVRHYLQGRSSIAGLLLKATNEKL 2696 Score = 32.3 bits (72), Expect = 3.5 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%) Query: 114 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 E QK + +E K A + + + AL E A T+ E E L Sbjct: 1011 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1060 Query: 174 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233 E+ R L + KL+ ++ Q A E R LK + A E+E Sbjct: 1061 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1115 Query: 234 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293 L++ +AE Q + LR++L A ++ ++Q+ +VE+ Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1161 Query: 294 AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346 +AQL+E Q + A T +R+ Q+ + L A ++ +E+++ Sbjct: 1162 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220 Query: 347 ------GQADYEEVKKELNILKSME 365 QA E++++E +L+ +E Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIE 1245 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 86.7 bits (213), Expect = 2e-16 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 +L++ +A A + + +E+SR R+ E+ R + R++ +GE+ AL Sbjct: 1451 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1505 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114 R++EAEA + A L +Q+Q + QR E E Sbjct: 1506 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1556 Query: 115 -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 Q+ + LEE + E + + +A E+ R+ + L+ + E + K + FA Sbjct: 1557 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1613 Query: 174 EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229 EK ER LQE ++ EEAE + Q Q E+ R E + E KA+E Sbjct: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1668 Query: 230 EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258 + E Q+ +AQ EAE +E QL+ Sbjct: 1669 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1728 Query: 259 SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315 +LA++ I+ + EQ + R LE ELA +RE A + Q L+A L K Sbjct: 1729 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1786 Query: 316 LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360 +R E S S + +Q+L A+ ++L EE + +A EE K++ + Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1846 Query: 361 LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412 + + + A +E + A E L+ + ++EN LR D + RR Sbjct: 1847 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1906 Query: 413 KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467 + + + R L S+L R G Q L+ Sbjct: 1907 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1958 Query: 468 PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524 S A+ GK L L R + SK E + ++ +Q Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2018 Query: 525 QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583 +S A + + ++ E E + E AR+++E+ + + Q L L+Q Sbjct: 2019 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2067 Query: 584 GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643 + + L + + V+ KE +++Q L EQ++L Q ++ R + Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2118 Query: 644 EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703 E + R +E R E ++ +S EQA+ Q Q AE + + + Sbjct: 2119 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2177 Query: 704 DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748 A ++ L+Q A EME + + L+Q + ++T L +L T Sbjct: 2178 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225 Score = 67.4 bits (163), Expect = 1e-10 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73 DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q + R +E Sbjct: 1174 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1228 Query: 74 AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127 E L Y+ D LG LQ +R I+ ++Q +RE L + Sbjct: 1229 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1280 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 E++ EK+ E ++ K I K+ +LQ Sbjct: 1281 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1319 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 + + K +Q+ E E DL+T Y E TT + I+ I L R + +A+ Sbjct: 1320 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379 Query: 248 REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301 ++ RE+L+ +L+ Q+ KA +A E+ R ++ E+ +E Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1437 Query: 302 LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356 + + +Q L +LR++S ++I +Q A + ++EE+++ Q + E ++ Sbjct: 1438 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1497 Query: 357 ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412 EL L++ E A ++ Q+ A+ L R +Q E+ R + +L+ + Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1550 Query: 413 KGKDQPESRR 422 + + E +R Sbjct: 1551 EAEAAREKQR 1560 Score = 63.9 bits (154), Expect = 1e-09 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65 R K +++ T L + +E++ + L E+ + K E R+ QV L S + +++ Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125 LSK EA + R D + + LQ + +++ + E +L +E Sbjct: 2266 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317 Query: 126 NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 + + AE + + + K LKEK++ ++ + +AE L+++++L E+ R+LQ Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2374 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 E + +L E + Q Q LE R ++ +A+A+ +++ + ++ RA Sbjct: 2375 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2423 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 RAE +A+ R+Q L ELA +E+ Sbjct: 2424 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2457 Query: 301 QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 ++QR Q+ +LRE I++LE++ +EKL+ +A ++K E Sbjct: 2458 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2502 Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418 E E Q + + LL++ R ++ E A L D A++ ++Q Sbjct: 2503 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2562 Query: 419 ESRR 422 ++ Sbjct: 2563 RQQQ 2566 Score = 60.1 bits (144), Expect = 2e-08 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66 +A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++ Sbjct: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040 Query: 67 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125 L + +EA +RL + + A +QLQL + ++ E + +++ Sbjct: 2041 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185 +E + QE +++ +++R + + AE A E + + + A+ R+++E + Sbjct: 2089 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2144 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238 S E+A+ + Q+ Q A EK R E + + A + + ++E+ Sbjct: 2145 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203 Query: 239 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297 Q+A+V Q E TLR QL +H L + + E RS +E EL + Sbjct: 2204 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2262 Query: 298 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326 ++ +L ++ QR LQ K+++ A+++ Q Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2322 Query: 327 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383 L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + + Sbjct: 2323 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2382 Query: 384 LLLEKNRSLQSENAALRISNSDLSGSARR 412 L E+ + Q A R ++S A R Sbjct: 2383 QLAEETQGFQRTLEAERQRQLEMSAEAER 2411 Score = 48.1 bits (113), Expect = 6e-05 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%) Query: 5 AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58 A A L ++ A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK Sbjct: 2354 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413 Query: 59 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115 E+ R++E F K+ ++ + + +L Q ++ + + +I+ + Sbjct: 2414 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2470 Query: 116 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163 ++LRE + E +E E QE + LK + + Q + ET AL+ Sbjct: 2471 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529 Query: 164 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200 K Q+L+ + +++++++ + + +EEA + Sbjct: 2530 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2589 Query: 201 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260 + + + + EL L+ + ++ A+E + + L+ ++ A +E + +A Sbjct: 2590 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2649 Query: 261 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318 +L P E E + L +++A+ + A ++ E++QRL T + E Sbjct: 2650 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2708 Query: 319 NSASQISQ--LEQQLSAKNSTLKQLEEKL 345 + + + L+ + S LK EKL Sbjct: 2709 LARREDVRHYLQGRSSIAGLLLKATNEKL 2737 Score = 32.3 bits (72), Expect = 3.5 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%) Query: 114 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173 E QK + +E K A + + + AL E A T+ E E L Sbjct: 1052 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1101 Query: 174 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233 E+ R L + KL+ ++ Q A E R LK + A E+E Sbjct: 1102 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1156 Query: 234 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293 L++ +AE Q + LR++L A ++ ++Q+ +VE+ Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1202 Query: 294 AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346 +AQL+E Q + A T +R+ Q+ + L A ++ +E+++ Sbjct: 1203 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261 Query: 347 ------GQADYEEVKKELNILKSME 365 QA E++++E +L+ +E Sbjct: 1262 AMPLADSQAVREQLRQEQALLEEIE 1286 >gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo sapiens] Length = 1938 Score = 82.4 bits (202), Expect = 3e-15 Identities = 103/427 (24%), Positives = 191/427 (44%), Gaps = 49/427 (11%) Query: 4 VAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS---F 60 VA R K E DA R +E E+++K+L ++ +E ++NT E + A L K+ Sbjct: 1372 VAQWRTKYETDAI-----QRTEELEEAKKKLAQRLQEAEENT-ETANSKCASLEKTKQRL 1425 Query: 61 QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE 120 QGE++ L + + + A + K+ + D V A + Q+L L + E++ L Sbjct: 1426 QGEVEDLMRDLERSHTACATLDKKQRNF-DKVLA-EWKQKLDESQAELEAAQKESRSLST 1483 Query: 121 TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180 L + + EV +Q ++ L+ + + ++ + + E IA E + LQ AEK +KL Sbjct: 1484 ELFKMRNAYEEVVDQ---LETLRRENKNLQEEISDLTEQIA-ETGKNLQE--AEKTKKLV 1537 Query: 181 ETQMSTTS-KLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERA 239 E + S LEE E ++ ++ + + + EL +K++ D + K +EIE + + +RA Sbjct: 1538 EQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRA 1597 Query: 240 ---------------NQRAEVAQREAETLREQLSSANHSLQLASQIQK--------APDV 276 N + ++ L E HS + ++ QK D Sbjct: 1598 AEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS 1657 Query: 277 EQAIEVLTRSS--LEVELAAKEREIAQLVEDVQRLQASL------TKLRENSASQISQLE 328 + ++ RS+ L+ +LA ER L+E+++ ++ +L +L E S Sbjct: 1658 QLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRV 1717 Query: 329 QQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 388 Q L ++N++L ++KL+ + + E +I +S DAA E L E+ Sbjct: 1718 QLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQ 1777 Query: 389 NRSLQSE 395 + S E Sbjct: 1778 DTSAHLE 1784 Score = 76.3 bits (186), Expect = 2e-13 Identities = 104/447 (23%), Positives = 193/447 (43%), Gaps = 38/447 (8%) Query: 11 RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKR 70 +EL A L + E+E + + IE+ R E++ ++ L+ G A + Sbjct: 1113 KELQARIEEL-EEEIEAEHTLRAKIEKQRSDLARELEEISER----LEEASGATSAQIEM 1167 Query: 71 SKEAEAAFLNVYKRLID--VPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKE 128 +K+ EA F + + L + + A L ++ V L + Q++++ LE+ E Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSE 1227 Query: 129 FA-EVKNQEVTIKAL---KEKIREYEQTLKNQAETIALEKEQKLQ--NDFAEKERKLQET 182 E+ + I+AL K I +T+++Q I + EQ+ Q +D ++ +LQ Sbjct: 1228 LKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQ 1287 Query: 183 QMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK---ADEIEMIMTDLERA 239 + ++EE E + L + + +L +LK + +EET AK A ++ D + Sbjct: 1288 NGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLL 1347 Query: 240 NQRAEVAQREAETLREQLSSANHSLQL------ASQIQKAPDVEQAIEVLTRSSLEVE-- 291 ++ E Q L+ LS AN + IQ+ ++E+A + L + E E Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407 Query: 292 LAAKEREIAQLVEDVQRLQASLTKLR---ENSASQISQLEQQLSAKNSTLKQLEEKL-KG 347 + A L + QRLQ + L E S + + L+++ + L + ++KL + Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDES 1467 Query: 348 QADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLS 407 QA+ E +KE L S E A + ++++ +L+ EN L+ SDL+ Sbjct: 1468 QAELEAAQKESRSL-STELFKMRNAYEE---------VVDQLETLRRENKNLQEEISDLT 1517 Query: 408 GSARRKGKDQPESRRPGSLPAPPPSQL 434 GK+ E+ + L S L Sbjct: 1518 EQIAETGKNLQEAEKTKKLVEQEKSDL 1544 Score = 72.0 bits (175), Expect = 4e-12 Identities = 84/403 (20%), Positives = 177/403 (43%), Gaps = 34/403 (8%) Query: 8 RLKRELDAT-ATVLANRQDESE-QSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEID 65 RL+ AT A + N++ E+E Q +R +E++ + T LRK+ A + +ID Sbjct: 1153 RLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQID 1212 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPAL-----DLGQQLQLKVQRLHDIETENQKLRE 120 L + ++ E + + D+ + AL ++ + + + +I+ ++++ + Sbjct: 1213 NLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQ 1272 Query: 121 TLEEYNKEFAEVKNQEVTI-------KALKEKIREYEQTLKNQAETIA--LEKEQKLQND 171 + + N + A ++ Q + ++L ++ + +Q L Q E + +E+E K +N Sbjct: 1273 LIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNA 1332 Query: 172 FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 231 A + + + EE + LQ AL K +E+ +TKY+ + + +E+E Sbjct: 1333 MAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1392 Query: 232 IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRS----- 286 L QR + A+ ET + +S + Q + +VE + L RS Sbjct: 1393 AKKKLA---QRLQEAEENTETANSKCASLEKTKQ-----RLQGEVEDLMRDLERSHTACA 1444 Query: 287 SLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK 346 +L+ + ++ +A+ + + QA L ++ S S ++L + +A + QLE + Sbjct: 1445 TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRR 1504 Query: 347 GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKN 389 + +E +L E G Q+A K +++ EK+ Sbjct: 1505 ENKNLQEEISDLT-----EQIAETGKNLQEAEKTKKLVEQEKS 1542 Score = 63.2 bits (152), Expect = 2e-09 Identities = 79/412 (19%), Positives = 173/412 (41%), Gaps = 64/412 (15%) Query: 7 ARLKRELDATATVLAN---RQDESEQSRKRLIEQSREFKKNTPE------DLRKQVAPLL 57 A +K + + T LA R+ E E+ L+++ + + D ++ L+ Sbjct: 854 ATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLI 913 Query: 58 KS---FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL-----DLGQQLQLKVQRLH 109 KS + ++ L++R +E E + + ++ D +L DL L + H Sbjct: 914 KSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKH 973 Query: 110 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQT--------------LKN 155 E + + L E + + +++ ++ +++ ++ + Q L+ Sbjct: 974 ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQ 1033 Query: 156 QAETI--ALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFD 213 Q + + +LE+E+KL+ D +RKL+ + + + E+ Q ++ L+K EL Sbjct: 1034 QTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ 1093 Query: 214 LKTKYDEETT------AKADEIEMIMTDLER------------ANQRAEVAQREAETLRE 255 L+ K D+E K E++ + +LE QR+++A RE E + E Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLA-RELEEISE 1152 Query: 256 QLSSANHSLQLASQIQK---------APDVEQAI--EVLTRSSLEVELAAKEREIAQLVE 304 +L A+ + ++ K D+E+A T ++L + A E+ + ++ Sbjct: 1153 RLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQID 1212 Query: 305 DVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVK 355 ++QR++ L K + +I + + A + + +E + D + E+K Sbjct: 1213 NLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIK 1264 Score = 46.6 bits (109), Expect = 2e-04 Identities = 75/397 (18%), Positives = 165/397 (41%), Gaps = 60/397 (15%) Query: 7 ARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQ--VAPLLKSFQGEI 64 +++K ELD + + +E EQ ++ + + ++R + L K +G++ Sbjct: 1570 SQVKSELDRK---VIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626 Query: 65 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH--DIETENQKLRETL 122 + + + + K L V Q QLK +LH D N+ L+E L Sbjct: 1627 NEMEIQLGHSNRQMAETQKHLRTV-----------QGQLKDSQLHLDDALRSNEDLKEQL 1675 Query: 123 EEYNKE----FAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERK 178 + E++ +V ++ + R EQ L + ++ + L Q +K+ + Sbjct: 1676 AIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLE 1735 Query: 179 LQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDL-----KTKYDEETTAKADE----I 229 Q E E+ +Q + A EK + + D + K +++T+A + + Sbjct: 1736 ADIAQCQA-----EVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790 Query: 230 EMIMTDLERANQRAEV-----AQREAETLREQLSSANHSLQL-----ASQIQKAPDVEQA 279 E + DL+ AE +++ + L ++ + L + A ++ A E+ Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERK 1850 Query: 280 IEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLK 339 ++ +T + E + I +L + V +LQA + + Q + E+Q + + S + Sbjct: 1851 VKEMTYQAEE-----DHKNILRLQDLVDKLQAKVKSYKR----QAEEAEEQANTQLSRCR 1901 Query: 340 QLEEKLKGQADYEEV-KKELNILKSMEFAPSEGAGTQ 375 +++ +L+ A+ ++ + ++N L+ A S G+Q Sbjct: 1902 RVQHELEEAAERADIAESQVNKLR----AKSRDVGSQ 1934 >gi|205277396 dynactin 1 isoform 4 [Homo sapiens] Length = 1139 Score = 80.9 bits (198), Expect = 9e-15 Identities = 78/342 (22%), Positives = 163/342 (47%), Gaps = 28/342 (8%) Query: 47 EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 106 E LR QV L + +++ L + E +A + K I + Q+ Q +Q Sbjct: 84 EGLRAQVRDL----EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139 Query: 107 R-LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE 165 R L + E ++ E E Y +E A+ + KE E ++L+ + E + E+ Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK-ERV 198 Query: 166 QKLQNDFAEKERKLQETQM---STTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 222 +L D + +++E +++ +L++ E + L+ AL + R D + Sbjct: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR----------DLSS 248 Query: 223 TAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIE 281 + K + +++ +E+ NQ EV +++ E L+E+LS A ++ +L Q+ A E+ +E Sbjct: 249 SEKQEHVKLQKL-MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE 307 Query: 282 VLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 341 +LT +L +E K RE+ + V D++ + +L+EN+ +L +QL + +++ Sbjct: 308 MLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 365 Query: 342 EEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAA 378 +++++ ADY++ +KK + ++ E Q+A+ Sbjct: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS 407 Score = 76.6 bits (187), Expect = 2e-13 Identities = 70/283 (24%), Positives = 129/283 (45%), Gaps = 24/283 (8%) Query: 143 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 201 +E +R + L+ + ET+ L++ E K + EK + E SK++E + +Q Sbjct: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142 Query: 202 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 261 K E + K +Y EE AD IEM D E A +RAE Q+E E L+E++ Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202 Query: 262 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 321 L++ E+ + S + AA ++ QL E RL+ +L ++R+ S+ Sbjct: 203 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 248 Query: 322 SQISQ---LEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAA 378 S+ + L++ + KN L+ + ++ E +++EL+ +S E A Sbjct: 249 SEKQEHVKLQKLMEKKNQELEVVRQQ------RERLQEELSQAESTIDELKEQVDAALGA 302 Query: 379 KPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESR 421 + + +L ++N +L+ + LR + DL + Q +R Sbjct: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 345 Score = 37.4 bits (85), Expect = 0.11 Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%) Query: 83 KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 141 +++ P P L Q + + ++ + T Q+ EY+ E K V ++A Sbjct: 741 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 795 Query: 142 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 195 L+ +I + E LK ET+ E ++ L+ + +E +L + S ++A+ Sbjct: 796 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 855 Query: 196 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 254 +++ +QT LE+T+ L + +++E A +I+ + + QR ++R E LR Sbjct: 856 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915 >gi|205277392 dynactin 1 isoform 3 [Homo sapiens] Length = 1253 Score = 80.9 bits (198), Expect = 9e-15 Identities = 78/342 (22%), Positives = 163/342 (47%), Gaps = 28/342 (8%) Query: 47 EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 106 E LR QV L + +++ L + E +A + K I + Q+ Q +Q Sbjct: 198 EGLRAQVRDL----EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 253 Query: 107 R-LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE 165 R L + E ++ E E Y +E A+ + KE E ++L+ + E + E+ Sbjct: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK-ERV 312 Query: 166 QKLQNDFAEKERKLQETQM---STTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 222 +L D + +++E +++ +L++ E + L+ AL + R D + Sbjct: 313 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR----------DLSS 362 Query: 223 TAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIE 281 + K + +++ +E+ NQ EV +++ E L+E+LS A ++ +L Q+ A E+ +E Sbjct: 363 SEKQEHVKLQKL-MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE 421 Query: 282 VLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 341 +LT +L +E K RE+ + V D++ + +L+EN+ +L +QL + +++ Sbjct: 422 MLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 479 Query: 342 EEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAA 378 +++++ ADY++ +KK + ++ E Q+A+ Sbjct: 480 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS 521 Score = 76.6 bits (187), Expect = 2e-13 Identities = 70/283 (24%), Positives = 129/283 (45%), Gaps = 24/283 (8%) Query: 143 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 201 +E +R + L+ + ET+ L++ E K + EK + E SK++E + +Q Sbjct: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256 Query: 202 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 261 K E + K +Y EE AD IEM D E A +RAE Q+E E L+E++ Sbjct: 257 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 316 Query: 262 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 321 L++ E+ + S + AA ++ QL E RL+ +L ++R+ S+ Sbjct: 317 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 362 Query: 322 SQISQ---LEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAA 378 S+ + L++ + KN L+ + ++ E +++EL+ +S E A Sbjct: 363 SEKQEHVKLQKLMEKKNQELEVVRQQ------RERLQEELSQAESTIDELKEQVDAALGA 416 Query: 379 KPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESR 421 + + +L ++N +L+ + LR + DL + Q +R Sbjct: 417 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 459 Score = 37.4 bits (85), Expect = 0.11 Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%) Query: 83 KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 141 +++ P P L Q + + ++ + T Q+ EY+ E K V ++A Sbjct: 855 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 909 Query: 142 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 195 L+ +I + E LK ET+ E ++ L+ + +E +L + S ++A+ Sbjct: 910 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 969 Query: 196 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 254 +++ +QT LE+T+ L + +++E A +I+ + + QR ++R E LR Sbjct: 970 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 >gi|13259508 dynactin 1 isoform 2 [Homo sapiens] Length = 1144 Score = 80.9 bits (198), Expect = 9e-15 Identities = 78/342 (22%), Positives = 163/342 (47%), Gaps = 28/342 (8%) Query: 47 EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 106 E LR QV L + +++ L + E +A + K I + Q+ Q +Q Sbjct: 84 EGLRAQVRDL----EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139 Query: 107 R-LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE 165 R L + E ++ E E Y +E A+ + KE E ++L+ + E + E+ Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK-ERV 198 Query: 166 QKLQNDFAEKERKLQETQM---STTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 222 +L D + +++E +++ +L++ E + L+ AL + R D + Sbjct: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR----------DLSS 248 Query: 223 TAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIE 281 + K + +++ +E+ NQ EV +++ E L+E+LS A ++ +L Q+ A E+ +E Sbjct: 249 SEKQEHVKLQKL-MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE 307 Query: 282 VLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 341 +LT +L +E K RE+ + V D++ + +L+EN+ +L +QL + +++ Sbjct: 308 MLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 365 Query: 342 EEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAA 378 +++++ ADY++ +KK + ++ E Q+A+ Sbjct: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS 407 Score = 76.6 bits (187), Expect = 2e-13 Identities = 70/283 (24%), Positives = 129/283 (45%), Gaps = 24/283 (8%) Query: 143 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 201 +E +R + L+ + ET+ L++ E K + EK + E SK++E + +Q Sbjct: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142 Query: 202 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 261 K E + K +Y EE AD IEM D E A +RAE Q+E E L+E++ Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202 Query: 262 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 321 L++ E+ + S + AA ++ QL E RL+ +L ++R+ S+ Sbjct: 203 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 248 Query: 322 SQISQ---LEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAA 378 S+ + L++ + KN L+ + ++ E +++EL+ +S E A Sbjct: 249 SEKQEHVKLQKLMEKKNQELEVVRQQ------RERLQEELSQAESTIDELKEQVDAALGA 302 Query: 379 KPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESR 421 + + +L ++N +L+ + LR + DL + Q +R Sbjct: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 345 Score = 37.4 bits (85), Expect = 0.11 Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%) Query: 83 KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 141 +++ P P L Q + + ++ + T Q+ EY+ E K V ++A Sbjct: 741 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 795 Query: 142 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 195 L+ +I + E LK ET+ E ++ L+ + +E +L + S ++A+ Sbjct: 796 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 855 Query: 196 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 254 +++ +QT LE+T+ L + +++E A +I+ + + QR ++R E LR Sbjct: 856 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915 >gi|13259510 dynactin 1 isoform 1 [Homo sapiens] Length = 1278 Score = 80.9 bits (198), Expect = 9e-15 Identities = 78/342 (22%), Positives = 163/342 (47%), Gaps = 28/342 (8%) Query: 47 EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 106 E LR QV L + +++ L + E +A + K I + Q+ Q +Q Sbjct: 218 EGLRAQVRDL----EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273 Query: 107 R-LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE 165 R L + E ++ E E Y +E A+ + KE E ++L+ + E + E+ Sbjct: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK-ERV 332 Query: 166 QKLQNDFAEKERKLQETQM---STTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 222 +L D + +++E +++ +L++ E + L+ AL + R D + Sbjct: 333 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR----------DLSS 382 Query: 223 TAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIE 281 + K + +++ +E+ NQ EV +++ E L+E+LS A ++ +L Q+ A E+ +E Sbjct: 383 SEKQEHVKLQKL-MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE 441 Query: 282 VLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 341 +LT +L +E K RE+ + V D++ + +L+EN+ +L +QL + +++ Sbjct: 442 MLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 499 Query: 342 EEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAA 378 +++++ ADY++ +KK + ++ E Q+A+ Sbjct: 500 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS 541 Score = 76.6 bits (187), Expect = 2e-13 Identities = 70/283 (24%), Positives = 129/283 (45%), Gaps = 24/283 (8%) Query: 143 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 201 +E +R + L+ + ET+ L++ E K + EK + E SK++E + +Q Sbjct: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276 Query: 202 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 261 K E + K +Y EE AD IEM D E A +RAE Q+E E L+E++ Sbjct: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 336 Query: 262 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 321 L++ E+ + S + AA ++ QL E RL+ +L ++R+ S+ Sbjct: 337 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 382 Query: 322 SQISQ---LEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAA 378 S+ + L++ + KN L+ + ++ E +++EL+ +S E A Sbjct: 383 SEKQEHVKLQKLMEKKNQELEVVRQQ------RERLQEELSQAESTIDELKEQVDAALGA 436 Query: 379 KPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESR 421 + + +L ++N +L+ + LR + DL + Q +R Sbjct: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 479 Score = 37.4 bits (85), Expect = 0.11 Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%) Query: 83 KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 141 +++ P P L Q + + ++ + T Q+ EY+ E K V ++A Sbjct: 875 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 929 Query: 142 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 195 L+ +I + E LK ET+ E ++ L+ + +E +L + S ++A+ Sbjct: 930 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 989 Query: 196 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 254 +++ +QT LE+T+ L + +++E A +I+ + + QR ++R E LR Sbjct: 990 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1049 Score = 31.6 bits (70), Expect = 6.0 Identities = 35/163 (21%), Positives = 62/163 (38%), Gaps = 9/163 (5%) Query: 1350 ADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASAT 1409 ADT P++ + + + R T S G + P P ++ Sbjct: 101 ADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGV 160 Query: 1410 ATAAP-------AAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGL 1462 A A+ A+ + ++S + P + P A P P +S + P PS + GL Sbjct: 161 AGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGL 220 Query: 1463 PEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEPI-EWE 1504 + + LR K+A + + + LEK + E + EW+ Sbjct: 221 RAQVRDLEEKLETLRLKRAED-KAKLKELEKHKIQLEQVQEWK 262 >gi|122937424 one cut homeobox 3 [Homo sapiens] Length = 494 Score = 79.0 bits (193), Expect = 3e-14 Identities = 59/201 (29%), Positives = 93/201 (46%), Gaps = 30/201 (14%) Query: 1121 AMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGRE 1180 A + E++T + +R+ L ++ Q +F + IL +QG++SDLL PKPW KL GRE Sbjct: 316 AAAEEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKLK-SGRE 374 Query: 1181 PFVRMQLWLNDPNNVEKLMDMKRME--KKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASP 1238 F RM WL +P + +RM + A KR+ + +P Sbjct: 375 TFRRMWKWLQEP-------EFQRMSALRLAACKRKEQEQQKERALQP------------- 414 Query: 1239 QPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSR 1298 KK R+V ++ L +++ PS + ++ QL L+ +TV N+F N R R Sbjct: 415 ------KKQRLVFTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRR 468 Query: 1299 IRRELFIEEIQAGSQGQAGAS 1319 + EE G AGA+ Sbjct: 469 CMNR-WAEEPSTAPGGPAGAT 488 Score = 62.4 bits (150), Expect = 3e-09 Identities = 36/98 (36%), Positives = 63/98 (64%), Gaps = 5/98 (5%) Query: 541 SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT 600 SAG+ +E E++T E+A+++ +L +++I Q IF +L SQG++S++L PKPW+KL Sbjct: 313 SAGAAAE--EINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKLK 370 Query: 601 VRGKEPFHKMKQFLSDE--QNILALRSIQGRQRENPGQ 636 G+E F +M ++L + Q + ALR +++E Q Sbjct: 371 -SGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQ 407 Score = 62.4 bits (150), Expect = 3e-09 Identities = 30/66 (45%), Positives = 46/66 (69%), Gaps = 1/66 (1%) Query: 941 QEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFI 1000 +E++T E+ +++ +L + I Q IF +++L SQG++SD+L PKPWSKL + GRE F Sbjct: 319 EEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKL-KSGRETFR 377 Query: 1001 RMQLWL 1006 RM WL Sbjct: 378 RMWKWL 383 >gi|24307887 one cut homeobox 1 [Homo sapiens] Length = 465 Score = 78.2 bits (191), Expect = 6e-14 Identities = 58/205 (28%), Positives = 95/205 (46%), Gaps = 30/205 (14%) Query: 1125 ELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVR 1184 E++T + +R+ L ++ Q +F + +L +QG++SDLL PKPW KL GRE F R Sbjct: 291 EINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLK-SGRETFRR 349 Query: 1185 MQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQL 1244 M WL +P + M + A ++ D +G +P Sbjct: 350 MWKWLQEP----EFQRMSALRLAACKRKEQEHGKD--------------RGNTP------ 385 Query: 1245 KKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELF 1304 KKPR+V ++ L +++ PS + ++ QL L+ STV N+F N R R Sbjct: 386 KKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRR-----S 440 Query: 1305 IEEIQAGSQGQAGASDSPSARSGRA 1329 +++ Q +G S S S+ +A Sbjct: 441 LDKWQDEGSSNSGNSSSSSSTCTKA 465 Score = 69.7 bits (169), Expect = 2e-11 Identities = 57/200 (28%), Positives = 97/200 (48%), Gaps = 32/200 (16%) Query: 531 GMAPSPSQSESAGSVSEG------EEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQG 584 G A P+ S + VS G EE++T E+A+++ +L +++I Q IF VL SQG Sbjct: 266 GTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQG 325 Query: 585 SVSEILARPKPWNKLTVRGKEPFHKMKQFLSDE--QNILALR--------SIQGRQRENP 634 ++S++L PKPW+KL G+E F +M ++L + Q + ALR G+ R N Sbjct: 326 TLSDLLRNPKPWSKLK-SGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNT 384 Query: 635 GQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQV---------Q 685 + +F +V +R + + ++ S E +I +Q EL + Sbjct: 385 PKKPRLVFTDVQRR------TLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARR 438 Query: 686 KTAEPAQPSSASGSGNSDDA 705 ++ + Q +S SGNS + Sbjct: 439 RSLDKWQDEGSSNSGNSSSS 458 Score = 62.8 bits (151), Expect = 2e-09 Identities = 31/66 (46%), Positives = 46/66 (69%), Gaps = 1/66 (1%) Query: 941 QEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFI 1000 +E++T E+ +++ +L + I Q IF ++VL SQG++SD+L PKPWSKL + GRE F Sbjct: 290 EEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKL-KSGRETFR 348 Query: 1001 RMQLWL 1006 RM WL Sbjct: 349 RMWKWL 354 >gi|21735548 centrosomal protein 2 [Homo sapiens] Length = 2442 Score = 77.4 bits (189), Expect = 1e-13 Identities = 178/831 (21%), Positives = 333/831 (40%), Gaps = 127/831 (15%) Query: 9 LKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPL------LKSFQG 62 L+++ + VL ++ E E+ +Q E ++ +DL+KQ+ L L+ Sbjct: 1513 LEKDRETQRNVLEHQLLELEKK-----DQMIESQRGQVQDLKKQLVTLECLALELEENHH 1567 Query: 63 EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDL---GQQLQLKVQRLHDIETENQKLR 119 +++ K KE E L + LDL Q+LQ + ++HD+E+ + L Sbjct: 1568 KMECQQKLIKELEGQRETQRVALTHL-----TLDLEERSQELQAQSSQIHDLESHSTVLA 1622 Query: 120 ETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE-------------- 165 L+E ++ EVK+Q I+ L+ + Q L+ + + + L+KE Sbjct: 1623 RELQERDQ---EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTK 1679 Query: 166 ------QKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYD 219 ++++ E+ R+L + + EE + ++ + +LE + L D + + + Sbjct: 1680 ILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE 1739 Query: 220 ------EETTAKADEIEMIMTDLER--ANQRAEVAQREAE--TLREQLSSANHSLQLASQ 269 E D++E + L R ++QRE E L++QL A +L Q Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799 Query: 270 IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVED-VQRLQASLTKLRENSASQISQLE 328 ++ +++A L + E+E +E++ AQ E+ V+ +L E + + + Sbjct: 1800 SLQS-QLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858 Query: 329 QQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 388 +L ++LEE+L + + +E +L + +E + A L+ E+ Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEE--VLGDLR---AESREQEKALLALQQQCAEQ 1913 Query: 389 NRSLQSENAALRISNSDLSGSARRKGKDQP-ESRRPGSLPAPPPSQLPRNPGEQASNTNG 447 + + E AL+ +S L A K +DQ E+ R S + + R E G Sbjct: 1914 AQEHEVETRALQ--DSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG 1971 Query: 448 THQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQL-MQSFYSKAMQEAGSTSMI 506 + G Q + S SL A + LQ L +S+ ++EA + Sbjct: 1972 KAHAALQGKEQHLLEQAELSRSLE-------ASTATLQASLDACQAHSRQLEEA----LR 2020 Query: 507 FSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLI- 565 G + Q +QQ + E E E++ +A++V+E +I Sbjct: 2021 IQEGEIQDQDLRYQEDVQQLQQA-----LAQRDEELRHQQEREQLLEKSLAQRVQENMIQ 2075 Query: 566 -KHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALR 624 K N+GQ + GL Q SV E+ +LT+ K EQ IL LR Sbjct: 2076 EKQNLGQEREEEEIRGLHQ-SVREL--------QLTLAQK------------EQEILELR 2114 Query: 625 SIQGRQREN----PGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAK- 679 Q QR N P +E + + E + + E +++ L Q + Sbjct: 2115 ETQ--QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQREL--------ERLQAALRQTEA 2164 Query: 680 RELQVQKTAEPAQPSSA--SGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSD 737 RE++ ++ A+ S A S +S + LQ + E +++Q L L+ + Sbjct: 2165 REIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEK 2224 Query: 738 ITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEA 788 + +P ST+ + S + L + S G A P+P ++K++ Sbjct: 2225 ERLHSPGATSTAEL---GSRGEQGVQLGEVS-----GVEAEPSPDGMEKQS 2267 Score = 74.3 bits (181), Expect = 8e-13 Identities = 173/780 (22%), Positives = 310/780 (39%), Gaps = 88/780 (11%) Query: 10 KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLK-----SFQGEI 64 +R+ A TV + +S + L++++RE + E L ++ L + QG+ Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGD- 501 Query: 65 DALSKRSKEAEAAFLNVYKR-----LIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLR 119 A ++ ++ E L V +R ++ + + L + + L+ + L E + LR Sbjct: 502 SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR-EALESSHLEGELLR 560 Query: 120 E-------TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEK----EQKL 168 + L + AE+ + E T+K +R L E +AL+K +Q L Sbjct: 561 QEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620 Query: 169 QNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTAL---EKTRTELFDLKTKYDEETTAK 225 Q L+E S S++E AE +LQ L EK R L++ T + + Sbjct: 621 Q---------LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671 Query: 226 ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDV------EQ 278 + + DL + E Q++ R Q +A L QL + ++ +V E+ Sbjct: 672 EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK 731 Query: 279 AIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTL 338 V +++LEV L A ER+ L E +Q L+ +E S + + +QQ S T Sbjct: 732 EALVREKAALEVRLQAVERDRQDLAEQLQ----GLSSAKELLESSLFEAQQQNSVIEVTK 787 Query: 339 KQLEEKLKGQADYEEV-KKELNILK-SMEFAPSEGAGTQD-AAKPLEVLLLEKNRSLQSE 395 QLE +++ +EV + E+ LK ++ S+ +D AA+ L E +L+ + Sbjct: 788 GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847 Query: 396 NAALRISNSDLSGS-ARRKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPA 454 AA + L + + Q E + +L EQ + Sbjct: 848 KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE 907 Query: 455 GLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMI------FS 508 +Q S+L L L +LLQ Q + S+ ++ + + Sbjct: 908 ERTQ--AESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQET 965 Query: 509 TGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHN 568 TG T +Q L+++ + + Q ES+ + ++MD + +K QL+ + Sbjct: 966 TGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ--DKMDLQKQVEDLKSQLVAQD 1023 Query: 569 IGQRIFGHYV---LGLSQ--GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSD--EQNIL 621 QR+ V L +Q + + L R K L++ KE + Q +Q + Sbjct: 1024 DSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS 1083 Query: 622 ALR----SIQGRQRENPGQSLNRLFQEVPKRRN---GSEGNITTRIRASETGSDEAIKSI 674 ALR QG Q+E Q + L QEV ++ E + + AS + S+ Sbjct: 1084 ALRQDMQEAQGEQKELSAQ-MELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142 Query: 675 LEQAKRELQVQ---KTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQA 731 Q + Q+Q ++ E + A+ + A + +AQ A+L AL+QA Sbjct: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQA----------QAQAQLASLYSALQQA 1192 Score = 68.6 bits (166), Expect = 4e-11 Identities = 107/456 (23%), Positives = 199/456 (43%), Gaps = 75/456 (16%) Query: 7 ARLKRELDATATVLANRQD---ESEQSRKRLIEQSREFKKNTPE------DLRKQVAPLL 57 A+L++ +A A + A+ +D E E+ +K+L E + + T + + ++Q L Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA 725 Query: 58 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 117 ++ Q E +AL + E V + D+ + + L ++L L + + +N Sbjct: 726 RAVQ-EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELL--ESSLFEAQQQNSV 782 Query: 118 LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKER 177 + E K EV+ Q VT KE I+ + LK + +T + EQ + D A ++ Sbjct: 783 I-----EVTKGQLEVQIQTVT--QAKEVIQGEVRCLKLELDTERSQAEQ--ERDAAARQL 833 Query: 178 KLQETQMSTTSKLEEAEHKV-----------------QSLQTALEKTRTELFDLKTKYDE 220 E + T + ++A H+ Q L ALE E +L+ + E Sbjct: 834 AQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKE 893 Query: 221 ETTAKADEIEMIMTDLERANQRAEVA--QREAETLREQLSSANHSLQLASQIQKAPD--- 275 + T E+E I E +AE A Q + ET +E++S LQ ++ A Sbjct: 894 QQT----EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949 Query: 276 -------VEQAIEVLTRSSLEVELAAKEREIAQLV----EDVQRLQ---ASLTKLRENSA 321 V++ E T L+ +L +RE+ + +D+ LQ +SL + + + Sbjct: 950 RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ 1009 Query: 322 SQISQLEQQLSAKNSTLK----QLEEKLKGQADYEEVKKELNILK-SMEFAPSEGAGTQD 376 Q+ L+ QL A++ + + +++EKL+ +Y ++KEL K S+ + E Sbjct: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME------ 1063 Query: 377 AAKPLEVLLLEKNRSL-QSENAALRISNSDLSGSAR 411 K +L+L++ S+ Q E +ALR + G + Sbjct: 1064 --KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK 1097 Score = 64.3 bits (155), Expect = 8e-10 Identities = 149/735 (20%), Positives = 289/735 (39%), Gaps = 96/735 (13%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPE--DLRKQVAPLLKSFQGEID 65 +L ++L T +D+ ++ +RL + E + E DL++Q L Q E Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ----LSQNQEEKS 1302 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125 + E+ + +++ + + + +L Q+++ + +R ++ + L +E Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAEL-QRMEAQGER-ELLQAAKENLTAQVEHL 1360 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE--QKLQNDFAEKE---RKLQ 180 E + Q L+E +R LK + E + E+E Q LQ K + LQ Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 E T L E E +V++L R ++ +L+ + + + A +E++ DL++ N Sbjct: 1421 ENLALLTQTLAEREEEVETL-------RGQIQELEKQREMQKAA----LELLSLDLKKRN 1469 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 Q ++ Q + + L + S H L +A Q + EQ + V E+E K+RE Sbjct: 1470 QEVDLQQEQIQELEKCRSVLEH-LPMAVQ-----EREQKLTVQREQIRELE---KDRETQ 1520 Query: 301 QLVEDVQRLQ-ASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELN 359 + V + Q L+ ++ E+ Q+ L++QL +LEE ++ +++ + Sbjct: 1521 RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEE------NHHKMECQQK 1574 Query: 360 ILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPE 419 ++K +E + + A L + L E+++ LQ++++ + DL + ++ E Sbjct: 1575 LIKELE---GQRETQRVALTHLTLDLEERSQELQAQSSQIH----DLESHSTVLARELQE 1627 Query: 420 SRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFA 479 Q ++ EQ + L + L + + + Sbjct: 1628 R-----------DQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676 Query: 480 LNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQS 539 +L+ L Q +++E G +++Q L Q G PS +Q Sbjct: 1677 QTKILEEDLEQ--IKLSLRERG-------------RELTTQRQLMQERAEEGKGPSKAQR 1721 Query: 540 ESAGSV------SEGE---EMDTAEIARQVKEQLIKHNIG-QRIFGHYVLGLSQGSVSEI 589 S + E E + + +++K+QL + G R G L LSQ EI Sbjct: 1722 GSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE-QEI 1780 Query: 590 LARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRR 649 + + + +G+ ++ L + Q LA R Q L L QE ++ Sbjct: 1781 VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD----------QELEALQQE-QQQA 1829 Query: 650 NGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSI 709 G E + + A + G+ E L++ ELQ K + G A+ + Sbjct: 1830 QGQEERVKEKADALQ-GALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEV 1888 Query: 710 LQQARREMEAQQAAL 724 L R E Q+ AL Sbjct: 1889 LGDLRAESREQEKAL 1903 Score = 47.4 bits (111), Expect = 1e-04 Identities = 90/433 (20%), Positives = 171/433 (39%), Gaps = 46/433 (10%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLL---KSFQGEI 64 R+++EL+ L E EQ R +++++ ++ LR+ + K ++ Sbjct: 1045 RIQKELEREKASLTLSLMEKEQ-RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM 1103 Query: 65 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEE 124 + L + KE EA FL +L++ + + + L Q + + +LR T + Sbjct: 1104 ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQ 1162 Query: 125 YNKEFAEVK--NQEVTIKALKEKIREYEQTLKNQAETI--------------ALEKEQKL 168 AE + NQ L +Q L + E+ LE +Q Sbjct: 1163 LEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNG 1222 Query: 169 QNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADE 228 ++ L T +S + + A HK+ ++TR L D K +E T E Sbjct: 1223 ARSLFKRGPLL--TALSAEA-VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAE 1279 Query: 229 IEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEV-LTRSS 287 + T+L+ ++ Q E + +S L S++ + + +++ L R+ Sbjct: 1280 KSQVHTELQDLQRQLSQNQEEKSKWEGKQNS------LESELMELHETMASLQSRLRRAE 1333 Query: 288 LEVELAAKEREIAQ-----LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE 342 L+ A ERE+ Q L V+ LQA++ + R AS LE+ L S LK Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA-QASAAGILEEDLRTARSALKLKN 1392 Query: 343 EKLKGQADYEEVKKELNILK---------SMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQ 393 E+++ + + + +E LK ++ A ++ + L + E + + Sbjct: 1393 EEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQRE 1452 Query: 394 SENAALRISNSDL 406 + AAL + + DL Sbjct: 1453 MQKAALELLSLDL 1465 Score = 42.0 bits (97), Expect = 0.004 Identities = 92/424 (21%), Positives = 179/424 (42%), Gaps = 65/424 (15%) Query: 10 KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSK 69 K DA+ + RQD Q K +++ + ++ ++++ + + ++ AL + Sbjct: 939 KELADASQQLERLRQDMKVQKLKE--QETTGILQTQLQEAQRELKEAARQHRDDLAALQE 996 Query: 70 RSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQ-KLRETLEEYNKE 128 S +++ K++ D+ + A D Q+L +E E Q KLRET +EYN+ Sbjct: 997 ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL---------VEQEVQEKLRET-QEYNRI 1046 Query: 129 FAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 E++ ++ ++ +L EK E + +A++I ++ L+ D Sbjct: 1047 QKELEREKASLTLSLMEK--EQRLLVLQEADSIRQQELSALRQD---------------- 1088 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM--IMTDLERAN---QR 242 ++EA+ + + L +E R E+ + + + + +E+E I RA+ Q Sbjct: 1089 --MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146 Query: 243 AEVAQ-----REAETLREQLSSANH-SLQLASQIQKA---PDVEQAIEVLTRSSLEVELA 293 A+ AQ R E+ E L++ Q +Q Q A ++QA+ + S E+ Sbjct: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206 Query: 294 AKEREIAQLVEDVQRLQASLTK--------LRENSASQISQLEQQLSAKNST-------L 338 +E Q SL K E AS + +L Q L T + Sbjct: 1207 GDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQV 1266 Query: 339 KQLEEKLKG-QADYEEVKKEL-NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSEN 396 ++LEE+L +A+ +V EL ++ + + E + + LE L+E + ++ S Sbjct: 1267 QKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326 Query: 397 AALR 400 + LR Sbjct: 1327 SRLR 1330 >gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] Length = 2230 Score = 77.4 bits (189), Expect = 1e-13 Identities = 107/444 (24%), Positives = 214/444 (48%), Gaps = 62/444 (13%) Query: 7 ARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEID- 65 A KR++ T L +++E Q R R+ + + + E+LR+Q ++ E++ Sbjct: 367 AETKRQMHET---LEMKEEEIAQLRSRIKQMTTQ-----GEELREQKEKSERAAFEELEK 418 Query: 66 ALSKRSKEAEA-----AFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDI--ETENQKL 118 ALS K EA A ++ + I+ + L Q+L Q + D+ ++ +++ Sbjct: 419 ALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478 Query: 119 RETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLK-----NQAETIALEKEQKLQNDFA 173 + + + KE A K QE+T K L+ + RE+++ +K +Q+E + + +E++ Q A Sbjct: 479 AKLQKLHEKELAR-KEQELT-KKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA 536 Query: 174 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233 +E +LQ+ + T E+E+K++ LQ E RT + +L++ ++ ++ + + Sbjct: 537 LEELELQKKAILT-----ESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA 591 Query: 234 TDLERANQR--------AEVAQREAETLREQLSSA-NHSLQLASQIQKAPDVEQAIEVLT 284 LE + E + E E+L+ Q + LQ+ Q Q ++E+ E Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQ-QYQTEMEKLRE--- 647 Query: 285 RSSLEVELAAKEREI---AQLVE----DVQRLQASLTKLRENSASQISQ-------LEQQ 330 + E E K++EI A + E +++L T+L E+ +S++S+ LE++ Sbjct: 648 KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTEL-ESLSSELSEVLKARHKLEEE 706 Query: 331 LSA-KNSTLK---QLEEKLKGQADYEEVKKELNILKSMEFA-PSEGAGTQDAAKPLEVLL 385 LS K+ T K +LE K+ Q ++ + + + +I+K E + +D LE+LL Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVD-SIIKEHEVSIQRTEKALKDQINQLELLL 765 Query: 386 LEKNRSLQSENAALRISNSDLSGS 409 E+++ L+ A + +D+ S Sbjct: 766 KERDKHLKEHQAHVENLEADIKRS 789 Score = 65.9 bits (159), Expect = 3e-10 Identities = 101/437 (23%), Positives = 189/437 (43%), Gaps = 43/437 (9%) Query: 18 TVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAA 77 T + +++ EQ ++ L++ + E++ ++ L Q E+++LS E A Sbjct: 640 TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699 Query: 78 FLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEV 137 + + L + D + + ++ Q+ H Q++ ++E+ EV Q Sbjct: 700 RHKLEEELSVLKDQTDKMKQELEAKMDEQKNH----HQQQVDSIIKEH-----EVSIQR- 749 Query: 138 TIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKV 197 T KALK++I NQ E + E+++ L+ A E L+ + +L++A K+ Sbjct: 750 TEKALKDQI--------NQLELLLKERDKHLKEHQAHVEN-LEADIKRSEGELQQASAKL 800 Query: 198 QSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQL 257 Q+ T + TK EE A+ + +++ + ER +VA+ EA+ Sbjct: 801 DVFQSYQSATHEQ-----TKAYEEQLAQLQQ-KLLDLETERILLTKQVAEVEAQKKDVCT 854 Query: 258 SSANHSLQ---LASQIQKA-PDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASL 313 H +Q L Q++K ++EQ ++ LT+ E +L +E Q + + + + Sbjct: 855 ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV-YESKLEDGNKEQEQTKQILVEKENMI 913 Query: 314 TKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAG 373 ++RE +I L Q+LSAK ++ L E +YE K N K ME + Sbjct: 914 LQMREGQKKEIEILTQKLSAKEDSIHILNE------EYE--TKFKNQEKKMEKVKQKAKE 965 Query: 374 TQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQ 433 Q+ K ++L E + EN AL +S + +A K + ++ G A S+ Sbjct: 966 MQETLKK-KLLDQEAKLKKELENTALELSQKEKQFNA--KMLEMAQANSAGISDA--VSR 1020 Query: 434 LPRNPGEQASNTNGTHQ 450 L N EQ + H+ Sbjct: 1021 LETNQKEQIESLTEVHR 1037 Score = 63.9 bits (154), Expect = 1e-09 Identities = 96/446 (21%), Positives = 190/446 (42%), Gaps = 62/446 (13%) Query: 2 LCVAGARLKRELDATATVLANRQDESEQSRKRLIEQ---SREFKKNTPEDLRKQVAP--- 55 L A L+RE +L+ QD+S + L E+ ++ KK+ E+ + Sbjct: 160 LVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQ 219 Query: 56 LLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN 115 + Q ++ L +R + +NV DV P+P L+ ++ K Sbjct: 220 YISVLQTQVSLLKQRLRNGP---MNV-----DVLKPLPQLEPQAEVFTK----------- 260 Query: 116 QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQ--------- 166 E E + E T++ L+++++ E LK ETI KEQ Sbjct: 261 ---EENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE 317 Query: 167 KLQNDFAEKER---KLQETQMSTTSK----LEEAEHKVQSLQ----TALEKTRTELFDLK 215 LQ E+ + K+++ M+ +K L +A++ ++ L+ + +T+ ++ + Sbjct: 318 ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL 377 Query: 216 TKYDEETTAKADEIEMIMTDLERANQRAEVAQREA-ETLREQLSSANHSLQLASQIQKAP 274 +EE I+ + T E ++ E ++R A E L + LS+A + + +++ Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437 Query: 275 DVE-QAIEVLT---RSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 330 D + + IE + R SL+ EL+ ++E+ +++ + + + KL++ ++++ EQ+ Sbjct: 438 DEQIKTIEKTSEEERISLQQELSRVKQEVVDVMK--KSSEEQIAKLQKLHEKELARKEQE 495 Query: 331 LSAKNSTLKQLEEKLKGQADYEEVKKELNILK-SMEFAPSEGAGTQDAAKPLEVLLLE-- 387 L+ K L+ E + + Q K + LK S E E ++ + +L E Sbjct: 496 LTKK---LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESE 552 Query: 388 -KNRSLQSENAALRISNSDLSGSARR 412 K R LQ E R +L S + Sbjct: 553 NKLRDLQQEAETYRTRILELESSLEK 578 Score = 63.5 bits (153), Expect = 1e-09 Identities = 100/439 (22%), Positives = 185/439 (42%), Gaps = 64/439 (14%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKK---NTPEDLRKQV----APLLKSF 60 + K + V ++ E +K+L++Q + KK NT +L ++ A +L+ Sbjct: 948 KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007 Query: 61 Q----GEIDALSK---RSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDI-- 111 Q G DA+S+ KE + V++R ++ + L QQ + ++Q +H+I Sbjct: 1008 QANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAE-ELQEIHEIQL 1066 Query: 112 ---ETENQKLRETL-------EEYNKEFAEVKN----QEVTIKALKEKIREYEQTLKN-- 155 E E +L++ + EE NKE +K Q+ T+ L+E++++ + + Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126 Query: 156 QAETIALEKEQKLQNDFAEKERK---LQETQMSTTSKLEEAEHKVQSLQTALEKTRTELF 212 Q ET +KL+ D + ++ LQE + EE + KV L + L+ T E Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQ 1186 Query: 213 DLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQK 272 LK+ +++ + D+ E + ++ ++ E L E + N + ++S Sbjct: 1187 SLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE--AKTNELINISSSKTN 1244 Query: 273 APDVEQAIEVLTRSSLEVELAAKEREIAQLVE--DVQRLQASLTKLRENSAS---QISQL 327 A +L+R S K +E A L++ V L+A L +L E + Q Sbjct: 1245 A--------ILSRISHCQHRTTKVKE-ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295 Query: 328 EQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE 387 QL K + +K + +AD E + E L+ EG Q AA E + + Sbjct: 1296 THQLEEKENQIKSM------KADIESLVTEKEALQ------KEGGNQQQAASEKESCITQ 1343 Query: 388 KNRSLQSENAALRISNSDL 406 + L A+ + +L Sbjct: 1344 LKKELSENINAVTLMKEEL 1362 Score = 62.8 bits (151), Expect = 2e-09 Identities = 75/311 (24%), Positives = 147/311 (47%), Gaps = 46/311 (14%) Query: 101 LQLKVQRLHDIETENQKL---RETLEEYNKEF-AEVKNQEVTIKALKEKIREYEQTLKNQ 156 LQ++ + +IE QKL +++ N+E+ + KNQE ++ +K+K +E ++TLK + Sbjct: 914 LQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK 973 Query: 157 AETIALEKEQKLQNDFAEKERKLQETQMSTTSK-LEEAEHKVQSLQTALEKTRTELFDLK 215 L++E KL+ + +L + + +K LE A+ + A+ + T + K Sbjct: 974 ----LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET---NQK 1026 Query: 216 TKYDEETTAKADEIEMIMTDLE-RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAP 274 + + T E+ +++ E + NQ+AE Q H +QL + Q+ Sbjct: 1027 EQIESLTEVHRRELNDVISIWEKKLNQQAEELQE------------IHEIQLQEKEQEVA 1074 Query: 275 DVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAK 334 +++Q I + E+ +EI L E+ + +L +L+E QL+Q+ SA Sbjct: 1075 ELKQKILLFGCEKEEM-----NKEITWLKEEGVKQDTTLNELQE-------QLKQK-SAH 1121 Query: 335 NSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQS 394 ++L Q E KLK + K E+++ KS++ E Q+ L++L E R + Sbjct: 1122 VNSLAQDETKLKAHLE----KLEVDLNKSLK----ENTFLQEQLVELKMLAEEDKRKVSE 1173 Query: 395 ENAALRISNSD 405 + L+ ++ + Sbjct: 1174 LTSKLKTTDEE 1184 Score = 60.1 bits (144), Expect = 2e-08 Identities = 91/414 (21%), Positives = 175/414 (42%), Gaps = 81/414 (19%) Query: 26 ESEQSRKRLIEQS-REFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKR 84 ES QS ++ +S + T ++ + K+++ +I L + E E V + Sbjct: 1699 ESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE 1758 Query: 85 LIDVPDPVPALDLGQQLQLKVQRLHDIETENQK-------LRETLEEYNKEFAEVKNQEV 137 + ++ Q Q ++ +L E + + L+E LEE NK+++ + Q V Sbjct: 1759 KEETVSS--HFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV 1816 Query: 138 TIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKV 197 + K I + +Q L+N F + ++ LQE +++ + E K+ Sbjct: 1817 EKEGGKNNI----------------QAKQNLENVFDDVQKTLQEKELTC----QILEQKI 1856 Query: 198 QSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQL 257 + L + L + + ++ EE T+K ++++ + ++ N+ E+ + E Sbjct: 1857 KELDSCLVRQK----EVHRVEMEELTSKYEKLQALQ-QMDGRNKPTELLEENTEE----- 1906 Query: 258 SSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLR 317 S +H +Q P + +E + LE +LA ERE +L +++ RLQ L LR Sbjct: 1907 KSKSHLVQ--------PKLLSNMEA-QHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957 Query: 318 ---------------ENSASQISQLEQQLSAK-NSTLKQLEEKLKGQADYEEVKKELNIL 361 + +I Q ++ L K NSTLKQL + Q +E + E+ I Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017 Query: 362 KSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALR---ISNSDLSGSARR 412 + T + A+ +E LLE ++ + N L+ + DL +A+R Sbjct: 2018 E-----------TINKAQEVEAELLESHQ--EETNQLLKKIAEKDDDLKRTAKR 2058 Score = 56.2 bits (134), Expect = 2e-07 Identities = 81/367 (22%), Positives = 161/367 (43%), Gaps = 51/367 (13%) Query: 13 LDATATVLANRQDESEQSRKRLIEQSRE--FKKNTPEDLRKQVAPLLKSFQGEIDALSKR 70 L +++ + + ++ + L++Q ++ FK +T L K+ L+ + S+ Sbjct: 1389 LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT---LSKEKISALEQVDDWSNKFSEW 1445 Query: 71 SKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFA 130 K+A++ F + +L QL+LK + ++ + + L+E L++ NK F Sbjct: 1446 KKKAQSRFTQHQNTV---------KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFD 1496 Query: 131 EVKNQEVTIKA-LKEKIREYEQTLKNQA------------ETIALE------KEQKLQND 171 +K + K+ +++K E LK+Q +TI +E K Q D Sbjct: 1497 CLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKD 1556 Query: 172 FAEKE-----RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDE---ETT 223 KE + QE ++++EAE K+ +L+ + + EL K + + Sbjct: 1557 IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVK 1616 Query: 224 AKADEIEMIMTDLERANQRAEVAQREAETLRE-QLSSANHSLQLASQIQKAPDVEQAIEV 282 +K +E++ + LE +E A + AE R+ + A QL SQ+++ + + Sbjct: 1617 SKEEELKALEDRLE-----SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTE 1671 Query: 283 LTRSSLEVELAAKEREIAQLVEDVQRLQASL--TKLRENSASQISQLEQQLSA--KNSTL 338 S L +L +ERE+ L E ++ +++S T + SA ++ +Q A + Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731 Query: 339 KQLEEKL 345 K EEK+ Sbjct: 1732 KTYEEKI 1738 Score = 55.5 bits (132), Expect = 4e-07 Identities = 63/309 (20%), Positives = 141/309 (45%), Gaps = 41/309 (13%) Query: 111 IETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 170 + +E + L+E L+E +E ++K+ + A K K+ + KN E + +K + Sbjct: 312 LTSEKEALQEQLDERLQELEKIKDLHM---AEKTKLITQLRDAKNLIEQLEQDKGMVI-- 366 Query: 171 DFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIE 230 AE +R++ ET LE E ++ L++ +++ T+ +L+ + ++ A +E+E Sbjct: 367 --AETKRQMHET-------LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 417 Query: 231 MIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS--- 287 ++ ++ + + E + + + + +++ Q + + ++ ++V+ +SS Sbjct: 418 KALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ 477 Query: 288 -------LEVELAAKEREIAQLVEDVQR-LQASLTKLRENSASQISQLEQQLSAKNS-TL 338 E ELA KE+E+ + ++ +R Q + E S S+ ++ Q+ + S L Sbjct: 478 IAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL 537 Query: 339 KQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAA 398 ++LE L+ +A E + +L L Q A+ +LE SL+ Sbjct: 538 EELE--LQKKAILTESENKLRDL-------------QQEAETYRTRILELESSLEKSLQE 582 Query: 399 LRISNSDLS 407 + + DL+ Sbjct: 583 NKNQSKDLA 591 Score = 47.0 bits (110), Expect = 1e-04 Identities = 68/319 (21%), Positives = 135/319 (42%), Gaps = 47/319 (14%) Query: 107 RLHDIETENQKLRETLEEYNKEFAEVKN---QEVTIKALKEKIREYEQTLKNQAETIALE 163 +L E E QKL + + K+ ++ QE+ I KE +E E+ +K + E + L+ Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILK-KEYDQEREEKIKQEQEDLELK 1989 Query: 164 KEQKLQN-------DFAEKERKLQETQMSTTSKLEEAEHKV-----QSLQTALEKTRTEL 211 L+ A+KE++L+ T T +K +E E ++ + L+K + Sbjct: 1990 HNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKD 2049 Query: 212 FDLKT---KYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLAS 268 DLK +Y+E A+ +E+ + DL+ Q E+ ++ + L ++ + N ++ + Sbjct: 2050 DDLKRTAKRYEEILDAREEEMTAKVRDLQ--TQLEELQKKYQQKLEQEENPGNDNVTI-- 2105 Query: 269 QIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLE 328 +E ++ +++L + KE+E E + L+ L K +N + Sbjct: 2106 -------MELQTQLAQKTTLISDSKLKEQEFR---EQIHNLEDRLKKYEKN----VYATT 2151 Query: 329 QQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLL-- 386 K L + L G+ E L+ + F G T+ AK + +L Sbjct: 2152 VGTPYKGGNLYHTDVSLFGE------PTEFEYLRKVLFEYMMGRETKTMAKVITTVLKFP 2205 Query: 387 --EKNRSLQSENAALRISN 403 + + L+ E+A L ++ Sbjct: 2206 DDQTQKILEREDARLMFTS 2224 >gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo sapiens] Length = 1939 Score = 77.4 bits (189), Expect = 1e-13 Identities = 147/757 (19%), Positives = 307/757 (40%), Gaps = 73/757 (9%) Query: 9 LKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTP-----EDLRKQVAPLLKSFQGE 63 L+ ++ A A LA+ ++ +Q K I+ + K+ T E++ ++ + + E Sbjct: 891 LQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950 Query: 64 IDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLE 123 L K + E V K + V +L +++ + + + E + L+E + Sbjct: 951 CSELKKDIDDLELTLAKVEKEKHATENKVK--NLTEEMAGLDETIAKLTKEKKALQEAHQ 1008 Query: 124 EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ 183 + + +++ T+ K K+ + L+ +LE+E+KL D +RKL+ Sbjct: 1009 QTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEG-----SLEQEKKLCMDLERAKRKLEGDL 1063 Query: 184 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETT------AKADEIEMIMTDLE 237 + E+ Q L L+K E+ +L+ K ++E K E++ + +LE Sbjct: 1064 KLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELE 1123 Query: 238 RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297 + ++ +AE R LS +++ ++++A A ++ E E R Sbjct: 1124 EEIEAERASRAKAEKQRSDLS--RELEEISERLEEAGGATSA-QIEMNKKREAEFQKMRR 1180 Query: 298 EIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKE 357 + L E + +A+ LR+ A +++L +Q+ +L+++++KL + + E+K E Sbjct: 1181 D---LEESTLQHEATAAALRKKHADSVAELGEQI----DSLQRVKQKL--EKEKSELKME 1231 Query: 358 LNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKD 416 +N L S ME A + + LE L E + + + ++LS R + Sbjct: 1232 INDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLI----NELSAQKARLHTE 1287 Query: 417 QPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTG 476 E R SQL R G+QA T Q L + + A +L A Sbjct: 1288 SGEFSRQLDEKDAMVSQLSR--GKQAF----TQQIEE--LKRQLEEETKAKSTLAHALQS 1339 Query: 477 KFALNSLLQRQLMQSFYSKA-----MQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD--V 529 LL+ Q + +KA M +A S + T Y T++I L+++ Sbjct: 1340 ARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRT-KYETDAIQRTEELEEAKKKLA 1398 Query: 530 NGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEI 589 + + E+ S E + +V++ +I ++ + L Q + ++ Sbjct: 1399 QRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMI--DVERSNAACIALDKKQRNFDKV 1456 Query: 590 LARPKPWNKLTVRGKEPFHKMKQFLSD---------EQNILALRSIQGRQRENPGQSLNR 640 LA K + T E K + LS E+++ L +++ R+ +N Q ++ Sbjct: 1457 LAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLK-RENKNLQQEISD 1515 Query: 641 LFQEVPKRRNGSEGNITTRIRAS--------ETGSDEAIKSILEQAKRELQVQKTAEPAQ 692 L +++ + G + +++ +T +EA S+ + + L++Q + Sbjct: 1516 LTEQIAE--GGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK 1573 Query: 693 PSSASGSGNSDDAIRSILQQARREMEAQQAALDPALK 729 D+ + + + R +E+ Q+ LD ++ Sbjct: 1574 SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIR 1610 Score = 57.0 bits (136), Expect = 1e-07 Identities = 72/325 (22%), Positives = 141/325 (43%), Gaps = 21/325 (6%) Query: 100 QLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAET 159 +L K++ L +++ EE+ K E+ E K L+EK+ Q KN + Sbjct: 835 KLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQE-KNDLQ- 892 Query: 160 IALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYD 219 + ++ E D E+ +L +T++ +K++E + + E+ EL K K + Sbjct: 893 LQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAED----EEEINAELTAKKRKLE 948 Query: 220 EETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQA 279 +E + +I+ + L + + + + + L E+++ L I K ++A Sbjct: 949 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKA 1002 Query: 280 IEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLS-AKNSTL 338 ++ + +L+ +L +E ++ L + +L+ + L E S Q +L L AK Sbjct: 1003 LQEAHQQTLD-DLQMEEDKVNTLTKAKTKLEQQVDDL-EGSLEQEKKLCMDLERAKRKLE 1060 Query: 339 KQLEEKLKGQADYEEVKKELN-ILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENA 397 L+ + D E K++LN LK EF S G + + L + L +K + LQ+ Sbjct: 1061 GDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQA--- 1117 Query: 398 ALRISNSDLSGSARRKGKDQPESRR 422 RI + A R + + E +R Sbjct: 1118 --RIEELEEEIEAERASRAKAEKQR 1140 Score = 48.1 bits (113), Expect = 6e-05 Identities = 91/432 (21%), Positives = 166/432 (38%), Gaps = 86/432 (19%) Query: 10 KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPE--DLRKQVAP----------LL 57 ++E + +T L ++ E+S L RE K E DL +Q+A + Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVK 1534 Query: 58 KSFQGEIDALSKRSKEAEAAF-------------LNVYKRLID--VPDPVPALDLGQQLQ 102 K E L +EAEA+ LN K ID + + LD Q Sbjct: 1535 KQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELD-----Q 1589 Query: 103 LKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKI----REYEQTLKNQAE 158 LK L +E+ L + N K E + ++ ++ R+ + L+N Sbjct: 1590 LKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRN 1649 Query: 159 TIALEKEQKLQNDFA---EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTR------- 208 T + K+ +L D A + + K Q + + L +AE V+ L+ +LE+T Sbjct: 1650 TQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAE--VEELRASLERTERGRKMAE 1707 Query: 209 -----------------TELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREA- 250 T L + K K + + + E+E I+ + A ++A+ A +A Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAA 1767 Query: 251 ----ETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE------VELAAKEREIA 300 E +EQ +SA+ + Q D++ ++ + +L+ +L A+ RE+ Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1827 Query: 301 QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKL----------KGQAD 350 VE Q+ K ++ +L Q + +L++ + K QA+ Sbjct: 1828 SEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAE 1887 Query: 351 YEEVKKELNILK 362 E + +N+ K Sbjct: 1888 EAEEQSNVNLAK 1899 Score = 48.1 bits (113), Expect = 6e-05 Identities = 40/208 (19%), Positives = 96/208 (46%), Gaps = 16/208 (7%) Query: 50 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 109 +K++ + QGE++ + + ++ AE K + D A + ++L+ + Sbjct: 1731 KKKLETDISQIQGEMEDIVQEARNAEE---KAKKAITD------AAMMAEELKKEQDTSA 1781 Query: 110 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 169 +E + + +T+++ E +++ +K K++I++ E ++ + E EQK Sbjct: 1782 HLERMKKNMEQTVKDLQLRLDEA--EQLALKGGKKQIQKLEARVRELESEV--ESEQKHN 1837 Query: 170 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDE---ETTAKA 226 + + RK + T + EE + LQ ++K +T++ K + +E ++ Sbjct: 1838 VEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL 1897 Query: 227 DEIEMIMTDLERANQRAEVAQREAETLR 254 + + +LE A +RA++A+ + LR Sbjct: 1898 AKFRKLQHELEEAKERADIAESQVNKLR 1925 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 77.0 bits (188), Expect = 1e-13 Identities = 108/514 (21%), Positives = 218/514 (42%), Gaps = 64/514 (12%) Query: 2 LCVAGARLKRELDATATVLANRQDESEQSRK---RLIEQSREFKKNTPEDLRKQV--APL 56 L ++L+ ELD +T+L + + + K L Q ++ ++ E+ R+++ + Sbjct: 1278 LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337 Query: 57 LKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL------DLGQQLQL---KVQR 107 ++ + E ++L ++ +E E A N+ K+++ + + DLG L K + Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397 Query: 108 LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIA-LEKEQ 166 L D E +Q+L E Y+K E T L++++ + L +Q + + LEK+Q Sbjct: 1398 LKDAEALSQRLEEKALAYDK-------LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ 1450 Query: 167 KLQNDFAEKERKLQ----ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 222 K + +E+ + E + ++ E E K SL ALE E + K +++ + Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE----EALEAKEEFERQN 1506 Query: 223 TAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIE 281 ++E +M+ + + ++ L +Q+ L +L ++Q D + +E Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE 1566 Query: 282 V---LTRSSLEVELAAKEREIAQ----LVEDVQRLQASLTKLRENSASQI---------- 324 V ++ E +L ++ + + L++ V+ L+A L R+ A + Sbjct: 1567 VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDL 1626 Query: 325 ----SQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKP 380 +Q+E A++ +KQL + DY+ +E + FA S+ ++ K Sbjct: 1627 KDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK--ESEKKLKS 1684 Query: 381 LEVLLLEKNRSLQSENAALRISN-------SDLSGSARRKGKDQPESRRPGSLPAPPPSQ 433 LE +L+ L S A R + +++ SA K E RR + A + Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744 Query: 434 LPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467 L EQ++ +F L D ++ LA+ Sbjct: 1745 LEE---EQSNMELLNDRFRKTTLQVDTLNAELAA 1775 Score = 72.4 bits (176), Expect = 3e-12 Identities = 79/317 (24%), Positives = 148/317 (46%), Gaps = 42/317 (13%) Query: 120 ETLEEYNKEFAEVKNQEVTIKA-LKEKIREYEQTLKN--------QAETIALEKEQKLQN 170 E L+ ++E +VK ++ ++ L+E R+++Q L+ QAET + ++++ Sbjct: 852 EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRA 911 Query: 171 DFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIE 230 A K+++L+E S++EE E + Q LQ +K + + DL+ + DEE A+ Sbjct: 912 RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ---- 967 Query: 231 MIMTDLERANQRAEVAQREAE--TLREQLSS------------ANHSLQLASQIQKAPD- 275 LE+ A++ + E E L +Q S A S QLA + +KA + Sbjct: 968 --KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025 Query: 276 --VEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 333 + EV+ S LE L +E+ +L + ++L T L++ QI++L+ Q+ Sbjct: 1026 AKIRNKQEVMI-SDLEERLKKEEKTRQELEKAKRKLDGETTDLQD----QIAELQAQIDE 1080 Query: 334 KNSTLKQLEEKLKG---QADYEEVKKE--LNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 388 L + EE+L+G + D E + K L +++ ++ +E ++ K ++ Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140 Query: 389 NRSLQSENAALRISNSD 405 R L E AL+ D Sbjct: 1141 KRDLSEELEALKTELED 1157 Score = 70.5 bits (171), Expect = 1e-11 Identities = 96/426 (22%), Positives = 167/426 (39%), Gaps = 21/426 (4%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 ++ REL A L + + SR + +Q R+ + E L+ ++ L + + + Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEEL-EALKTELEDTLDTTAAQQELR 1169 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127 +KR E E A L D+ Q+ ++ L + + ++ + LE+ NK Sbjct: 1170 TKR--EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK-NK 1226 Query: 128 EFAEVKNQEVT--IKALKEKIREYEQTLKN-----QAETIALEKEQKLQNDFAEKERKLQ 180 + E N+E+ +K L++ E E K Q + + +L+ + AEK KLQ Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286 Query: 181 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 + ++ LEEAE K ++L D + EET K + + + LE Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEK 1345 Query: 241 QRAEVAQREAETLREQLSSANHSL--QLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE 298 + Q E E R+ L +L QLA +K D IE L + + +L Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA--KKKLLKDAEA 1403 Query: 299 IAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 ++Q +E+ L K + ++ L L + LE+K K +K + Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463 Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVL-----LLEKNRSLQSENAALRISNSDLSGSARRK 413 + + E +E + K L + LE + +N LR DL S Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523 Query: 414 GKDQPE 419 GK+ E Sbjct: 1524 GKNVHE 1529 Score = 66.6 bits (161), Expect = 2e-10 Identities = 93/412 (22%), Positives = 171/412 (41%), Gaps = 31/412 (7%) Query: 10 KRELDATATVLANRQDESEQSRKRL----IEQSREFKKNTPE-----DLRKQVAPLLKSF 60 K+++ A L + DE E +R++L + + KK E D + K Sbjct: 945 KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1004 Query: 61 QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE 120 + I S + E E N+ K I V DL ++L+ + + ++E +KL Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAK--IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062 Query: 121 TLEEYNKEFAEVKNQEVTIKA-LKEKIREYEQTL-KNQAETIALEKEQKLQNDFAEKERK 178 + + AE++ Q +K L +K E + L + ET+ K+ + + + Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122 Query: 179 LQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFD----------LKTKYDEETT----A 224 LQE S + +AE + + L LE +TEL D L+TK ++E A Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182 Query: 225 KADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLT 284 +E + ++ QR A E EQ +L+ Q + + E A EV Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1242 Query: 285 RSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEK 344 ++ E K +++ V+++ + +LR A + S+L+ +L ++ L++ E+K Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK 1302 Query: 345 -LKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSE 395 +K D ++ +L + E E + + + L EKN SLQ + Sbjct: 1303 GIKFAKDAASLESQLQ--DTQELLQEETRQKLNLSSRIRQLEEEKN-SLQEQ 1351 Score = 62.8 bits (151), Expect = 2e-09 Identities = 144/625 (23%), Positives = 238/625 (38%), Gaps = 80/625 (12%) Query: 139 IKALKEKIREYEQTLKNQAETIAL-EKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKV 197 +K L + R+ E+ E + + EK+ K++ + E ERK Q+ LEE Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQL-------LEEKNILA 893 Query: 198 QSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQL 257 + LQ TELF + AK E+E I+ DLE ++ E E R Q+ Sbjct: 894 EQLQ-----AETELFAEAEEMRARLAAKKQELEEILHDLE--------SRVEEEEERNQI 940 Query: 258 SSANHSLQLASQIQKAPDVEQAI--EVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315 N ++ + IQ D+E+ + E R L++E E +I ++ E++ L+ +K Sbjct: 941 LQ-NEKKKMQAHIQ---DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSK 996 Query: 316 LRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQ 375 + +E +++ +S L + EEK K A K+E+ I E E Q Sbjct: 997 F----IKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN-KQEVMISDLEERLKKEEKTRQ 1051 Query: 376 DAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLP 435 + K L E LQ + A L+ +L +K E G+L L Sbjct: 1052 ELEKAKRKLDGE-TTDLQDQIAELQAQIDELKLQLAKK-----EEELQGALARGDDETLH 1105 Query: 436 RNPGEQASNTNGTHQFSPAGLSQDF----FSSSLASPSLPLASTGKFALNSLLQRQL--- 488 +N A Q A L +DF S + A S AL + L+ L Sbjct: 1106 KN---NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT 1162 Query: 489 --MQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSV- 545 Q +K QE T + +Q + + Q E A Sbjct: 1163 AAQQELRTKREQEVAELKKALEE---ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK 1219 Query: 546 ------SEGEEMDTAEIARQVKE-QLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNK 598 +G E D E+A +VK Q +K + V E+ A+ ++ Sbjct: 1220 ANLEKNKQGLETDNKELACEVKVLQQVKAE------SEHKRKKLDAQVQELHAKVSEGDR 1273 Query: 599 LTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLF---QEVPKRRNGSEGN 655 L V E K++ L + +L +G + SL QE+ + + N Sbjct: 1274 LRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN 1333 Query: 656 ITTRIRASETGSDEAIKSILEQAKRELQVQKTAE----PAQPSSASGSGNSDDAIRSI-- 709 +++RIR E E S+ EQ + E + +K E Q A DD + +I Sbjct: 1334 LSSRIRQLE----EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES 1389 Query: 710 LQQARREMEAQQAALDPALKQAPLS 734 L++A++++ AL L++ L+ Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALA 1414 Score = 53.1 bits (126), Expect = 2e-06 Identities = 69/325 (21%), Positives = 139/325 (42%), Gaps = 48/325 (14%) Query: 11 RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKR 70 R+L A +E+ SR + QS+E +K LKS + EI L + Sbjct: 1648 RKLQAQMKDYQRELEEARASRDEIFAQSKESEKK------------LKSLEAEILQLQEE 1695 Query: 71 SKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFA 130 +E A + + ++ D + G+ L +R +E +L E LEE Sbjct: 1696 LASSERARRHAEQERDELADEITNSASGKSALLDEKRR--LEARIAQLEEELEE------ 1747 Query: 131 EVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKL 190 E N E+ L ++ R+ + +A E+ ++D A ++ + Q ++ +KL Sbjct: 1748 EQSNMEL----LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK--AKL 1801 Query: 191 EEAEHKVQS-LQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQ---RAEVA 246 +E E V+S + + ++ L+ + ++E +A +++ ++ + + E Sbjct: 1802 QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDE 1861 Query: 247 QREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDV 306 +R A+ +EQ+ AN A Q +E+A E TR++ A R++ + ++D Sbjct: 1862 RRHADQYKEQMEKAN-----ARMKQLKRQLEEAEEEATRAN------ASRRKLQRELDDA 1910 Query: 307 QRLQASLTKLRENSASQISQLEQQL 331 T+ E + ++S L+ +L Sbjct: 1911 -------TEANEGLSREVSTLKNRL 1928 >gi|4502443 dystonin isoform 1e precursor [Homo sapiens] Length = 2649 Score = 74.7 bits (182), Expect = 6e-13 Identities = 92/449 (20%), Positives = 194/449 (43%), Gaps = 69/449 (15%) Query: 25 DESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKR 84 ++ EQ + +L+E+ R K++ E+L K + + K + K+ KE + L ++ Sbjct: 1264 NDLEQQKNKLMEELRR-KRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRK 1322 Query: 85 LIDVP-----DPVPALDLGQQLQLKV-----------------QRLHDIETENQK----L 118 + ++ + +P + Q + Q++ ++ N+K + Sbjct: 1323 ITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM 1382 Query: 119 RETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERK 178 RE E N E + E + LK+K+ E TL+ + LE++ + + ++++ R+ Sbjct: 1383 RELTYELNALQLEKTSSEEKARLLKDKLDETNNTLR--CLKLELERKDQAEKGYSQQLRE 1440 Query: 179 LQETQMSTTSKLEEAEHKVQSL-------QTALEKTRTELFDLKTKYDEETTAKA---DE 228 L TT K EEA + L Q LE E L+ + D T A A Sbjct: 1441 LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN 1500 Query: 229 IEMIMTDL-----ERANQRAEVAQREAETLREQLSSANHSL--QLASQIQKAPDVEQAIE 281 I+ + + + E+ +R ++ QR+++ L+EQ ++ L + ++ + +++ E Sbjct: 1501 IQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE 1560 Query: 282 VLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 341 L +S+ E+ + Q VE++ R Q + TKL +I + + + T++Q Sbjct: 1561 ELEKSNECAEM------LKQKVEELTR-QNNETKL---MMQRIQAESENIVLEKQTIQQR 1610 Query: 342 EEKLKGQAD-------------YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 388 E LK QAD +++ K E + + ++ + A +Q+ + ++ Sbjct: 1611 CEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQ 1670 Query: 389 NRSLQSENAALRISNSDLSGSARRKGKDQ 417 N +Q+ +R N++L+ S K + + Sbjct: 1671 NIIIQNTKKEVRNLNAELNASKEEKRRGE 1699 Score = 60.8 bits (146), Expect = 9e-09 Identities = 73/347 (21%), Positives = 136/347 (39%), Gaps = 44/347 (12%) Query: 28 EQSRKRLIEQSREFKKNTPEDLRKQ--VAPLLKSFQGEIDALSKRSKEAEAAFLN----- 80 E +++++ E E K L +Q + ++ Q ++D K +++ A + Sbjct: 984 ETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQT 1043 Query: 81 -VYKRLIDVPD--PVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEV 137 Y+ ++D PV + L +Q D+ T L + +Y K + Sbjct: 1044 MTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD------ 1097 Query: 138 TIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKV 197 ++K L+E + +K ET E +D ++++ T K+ E E V Sbjct: 1098 SLKRLEE------EEIKRCKET----SEHGAYSDLLQRQKATVLENSKLTGKISELERMV 1147 Query: 198 QSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQL 257 L+ + EL ++ + E + +E I RA A+ +RE ET+ + Sbjct: 1148 AELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREK 1207 Query: 258 SSANHSLQLASQIQKAPDVEQAI--------------EVLTRSSLEVELAAKEREIAQLV 303 +A L+ Q+ + ++A TR +LE L K+ + L Sbjct: 1208 EAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLE 1267 Query: 304 EDVQRLQASLTKLRENS---ASQISQLEQQLS-AKNSTLKQLEEKLK 346 + +L L + R+N I Q+E+ L+ K KQL+EK K Sbjct: 1268 QQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQK 1314 Score = 56.2 bits (134), Expect = 2e-07 Identities = 58/268 (21%), Positives = 119/268 (44%), Gaps = 36/268 (13%) Query: 104 KVQRLHD-IETENQ---KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAET 159 K+QRL++ +E N+ L++ +EE ++ E K I+A E I +QT++ + E Sbjct: 1554 KIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA 1613 Query: 160 IALE----------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTA 203 + ++ K+ K + DF K + L+E + + + E + K Sbjct: 1614 LKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNII 1673 Query: 204 LEKTRTELFDLKTKYD---EETTAKADEIEMIMTDLERANQRAEVAQRE--AETLREQLS 258 ++ T+ E+ +L + + EE ++++ ++ N R + Q E +T+ EQ++ Sbjct: 1674 IQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMT 1733 Query: 259 SANHSL---QLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315 L + Q A + + +E L S + E +I+ + D LQ ++ Sbjct: 1734 HRKMVLFQEESGKFKQSAEEFRKKMEKLMESKV-----ITENDISGIRLDFVSLQQENSR 1788 Query: 316 LRENS---ASQISQLEQQLSAKNSTLKQ 340 +EN+ + I +LE+QL ++Q Sbjct: 1789 AQENAKLCETNIKELERQLQQYREQMQQ 1816 Score = 55.5 bits (132), Expect = 4e-07 Identities = 76/365 (20%), Positives = 161/365 (44%), Gaps = 48/365 (13%) Query: 10 KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPE-DLRKQVAP-LLKSFQGEIDAL 67 + E+D V +DE ++++ E + +K+ + D K+ A L++ +Q + Sbjct: 893 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 952 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127 R ++ E + K L D LD + +ET +K++E E +K Sbjct: 953 DNRLRDLEG----IGKSLKYYRDTYHPLD---------DWIQQVETTQRKIQENQPENSK 999 Query: 128 EFA-EVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMST 186 A ++ Q++ + ++ K + ++ K + A K+ +LQ T + Sbjct: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQT----------MTYRAM 1049 Query: 187 TSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVA 246 +++ K + +Q++ + E DL+T+Y T I+ L+R Sbjct: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRL------- 1102 Query: 247 QREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDV 306 E E R + +S + + Q QKA VL S L +++ ER +A+L + Sbjct: 1103 -EEEEIKRCKETSEHGAYSDLLQRQKA-------TVLENSKLTGKISELERMVAELKKQK 1154 Query: 307 QRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL-NILKSME 365 R++ L K+RE + +++ +QQ + ++ +L +K++ +++ ++ ++EL I++ E Sbjct: 1155 SRVEEELPKVREAAENELR--KQQRNVEDISL----QKIRAESEAKQYRRELETIVREKE 1208 Query: 366 FAPSE 370 A E Sbjct: 1209 AAERE 1213 Score = 41.2 bits (95), Expect = 0.008 Identities = 30/127 (23%), Positives = 61/127 (48%), Gaps = 3/127 (2%) Query: 101 LQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKN--QAE 158 ++ KV +DI +E ++ K E IK L+ ++++Y + ++ E Sbjct: 1762 MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHME 1821 Query: 159 TIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKY 218 +K QKL+++ ++R+++ + +++E EH++ LQ ++K T D K Sbjct: 1822 ANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAK-DCTFKP 1880 Query: 219 DEETTAK 225 D E T K Sbjct: 1881 DFEMTVK 1887 Score = 37.0 bits (84), Expect = 0.14 Identities = 53/313 (16%), Positives = 118/313 (37%), Gaps = 20/313 (6%) Query: 96 DLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKN 155 +L +L+ LH E Q + + +E + K + EK+ E + +N Sbjct: 1711 ELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITEN 1770 Query: 156 QAETIALE-KEQKLQNDFAEKERKLQETQMSTTSK--------LEEAEH-------KVQS 199 I L+ + +N A++ KL ET + + +++ +H K Q Sbjct: 1771 DISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830 Query: 200 LQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSS 259 L+ L + E+ +LK K D++ ++ ++ ++++ + + + + Sbjct: 1831 LEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFK--PDFEMTVKE 1888 Query: 260 ANHSLQLASQI--QKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLR 317 HS +L+S+ P + T+ +E + R + Q+ ++VQ + Sbjct: 1889 CQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEK 1948 Query: 318 ENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDA 377 E S S+ Q S + + ++ E+++ + + A + Sbjct: 1949 EKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMEL 2008 Query: 378 AKPLEVLLLEKNR 390 K L L + KN+ Sbjct: 2009 VKVLTPLEIAKNK 2021 >gi|4506751 restin isoform a [Homo sapiens] Length = 1427 Score = 74.3 bits (181), Expect = 8e-13 Identities = 92/397 (23%), Positives = 174/397 (43%), Gaps = 46/397 (11%) Query: 24 QDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYK 83 Q + E +R + +EQS F+K + L++++ + E + + K+ V + Sbjct: 458 QTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAE 517 Query: 84 RLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQ-------- 135 + PA D+ L L L +I + +KL T ++ +E +K Sbjct: 518 LRRRLESNKPAGDVDMSLSL----LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH 573 Query: 136 EVTIKAL---KEKIREYEQTLKNQAE--------TIALEKEQKLQNDFAEKERKLQETQM 184 + IKAL EK+ + ++LK++ E IAL K KL+ A ++ ++E ++ Sbjct: 574 QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKS-KLETAIASHQQAMEELKV 632 Query: 185 STTSKLEEAEHKVQSLQTALEKTRT----ELFDLKTKYDEETTAKADEIEMIMTDLERAN 240 S + L + L+T +EK R E+ +L+ + D E A A E+E + L + Sbjct: 633 SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVI 692 Query: 241 QRAEVAQREAETLREQLSSA--NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE 298 + E E +R +L A H +++ + K + E ++ LEV L AK E Sbjct: 693 KEKE---NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK-----ELEV-LQAKCNE 743 Query: 299 IAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 +++++ S K E + L + S S +K+L ++L+ E+ K L Sbjct: 744 QTKVIDNF----TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHL 796 Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSE 395 I K+ E + + + + L++ L++N S S+ Sbjct: 797 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 833 Score = 73.2 bits (178), Expect = 2e-12 Identities = 79/397 (19%), Positives = 168/397 (42%), Gaps = 68/397 (17%) Query: 8 RLKRELDATATVLANRQDE--SEQSRKRLIE---QSREFKKNTPEDLRKQVAPLLKSFQG 62 +L+++L+A + + + E +E S+ I Q RE K ++ +V+ + ++ + Sbjct: 781 KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 840 Query: 63 EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETL 122 E+ L ++ EA ++V + + + + +L K ++ + + ++ +KLRE L Sbjct: 841 ELQILKEKFAEASEEAVSVQRSMQETVN---------KLHQKEEQFNMLSSDLEKLRENL 891 Query: 123 EEYNKEFAEVKNQEVTIKALKEKIR-EYEQTLKNQAETIALEKEQKLQNDFAEKERKLQE 181 + +F E +E + KEK+ + + +K + + + K+ ++ KER ++E Sbjct: 892 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS--QLTKMNDELRLKERDVEE 949 Query: 182 TQMSTTSKLEEA--------------------------------EHKVQSLQTALEKTRT 209 Q+ T E A E K+ L+ +E + Sbjct: 950 LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN 1009 Query: 210 ELFDLKTKYDEETTAKADEIEMIMTDLER----ANQRAEVAQREAETLREQLSSANHSLQ 265 + +LK +Y+ T+ + E I+ +L++ + + A+ E L ++L Sbjct: 1010 QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD 1069 Query: 266 LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQIS 325 A Q A D Q +E +T+ E + ++ + + +LQ L L+EN+ + Sbjct: 1070 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK-----QTNAKLQNELDTLKENNLKNVE 1124 Query: 326 QLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILK 362 +L K+ L +E + EE +KE+ LK Sbjct: 1125 ELN-----KSKELLTVENQ-----KMEEFRKEIETLK 1151 Score = 65.5 bits (158), Expect = 4e-10 Identities = 81/349 (23%), Positives = 152/349 (43%), Gaps = 74/349 (21%) Query: 47 EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 106 E LR ++ ++K + ++A+ + +AE + L+++ D + L Q+ ++KV+ Sbjct: 682 EALRAKLMKVIKEKENSLEAIRSKLDKAED------QHLVEMEDTLNKL---QEAEIKVK 732 Query: 107 RLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQ 166 L ++ + + + ++ + + +KA +EK+ + + K +E + K+ Sbjct: 733 ELEVLQAKCNEQTKVIDNFTSQ----------LKATEEKLLDLDALRKASSEGKSEMKKL 782 Query: 167 KLQNDFAEKERKLQETQ--------MSTTSKLEEAEHKVQSLQTAL-------EKTRTEL 211 + Q + AEK+ K E + S T +L+ E K+ +LQ L E EL Sbjct: 783 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 842 Query: 212 FDLKTKYDEETT-----------------AKADEIEMIMTDLERANQR---AEVAQREAE 251 LK K+ E + K ++ M+ +DLE+ + E RE + Sbjct: 843 QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 902 Query: 252 TLREQLSSANHSLQ--LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRL 309 EQL A L+ +A ++ + D + + + EL KER DV+ L Sbjct: 903 EREEQLIKAKEKLENDIAEIMKMSGDNSSQL-----TKMNDELRLKER-------DVEEL 950 Query: 310 QASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 Q LTK EN++ Q S ++ T+K + + + +EE KKEL Sbjct: 951 QLKLTKANENASF------LQKSIEDMTVKAEQSQQEAAKKHEEEKKEL 993 Score = 59.3 bits (142), Expect = 3e-08 Identities = 83/381 (21%), Positives = 162/381 (42%), Gaps = 47/381 (12%) Query: 1 MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF 60 +L +R R++ T T L E +Q ++L+ + DL + S Sbjct: 335 LLTETSSRYARKISGT-TALQEALKEKQQHIEQLLAE---------RDLERAEVAKATSH 384 Query: 61 QGEIDALSKRSKEA-EAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLR 119 GEI+ +++ + L + ++ + V A D + KV+ L+ +E E +K+ Sbjct: 385 VGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAAD-----REKVELLNQLEEEKRKVE 439 Query: 120 ETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTL---KNQAETIALEKEQKLQNDFAEKE 176 + +E + E K +I+E EQ+L K +A+ + E E +EK Sbjct: 440 DLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKS 499 Query: 177 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTR-TELFDLKTKYDEETTAKADEIEMIMTD 235 R + E + +++E V L+ LE + D+ +E ++ +++E+ TD Sbjct: 500 R-IMELEKDLALRVQE----VAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTD 554 Query: 236 LERA--------NQRAEVAQREAE---TLREQLSSANHSLQLASQIQKAPDVEQAIEVLT 284 +R R E Q+E + T E+LS N SL+ S+++ A + L Sbjct: 555 HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLK--SKLEHANKENSDVIALW 612 Query: 285 RSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEK 344 +S LE +A+ + + ++ L+ S +K ++ ++L+ Q+ + E Sbjct: 613 KSKLETAIASHQ-------QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIEN 665 Query: 345 LKGQADYEEV--KKELNILKS 363 L+ Q D E KE+ L++ Sbjct: 666 LQNQQDSERAAHAKEMEALRA 686 Score = 54.7 bits (130), Expect = 7e-07 Identities = 77/332 (23%), Positives = 146/332 (43%), Gaps = 47/332 (14%) Query: 99 QQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIR-----EYEQTL 153 +Q Q + + H E E ++L L + K+ NQ +KA E+ ++E+ L Sbjct: 976 EQSQQEAAKKH--EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL 1033 Query: 154 KNQAETIALEKEQKLQNDFAEKERKLQET-----QMSTTSKLEEAEHKVQSLQ------- 201 +N +T+ L+ E KL+ E LQE Q + AE +Q ++ Sbjct: 1034 QNLQKTL-LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1092 Query: 202 ---TALEKTRTELFDLKTKYD---EETTAKADEIEMIMTDLERANQRAEVAQREAETLR- 254 +LE T+ L+ + D E +E+ L NQ+ E ++E ETL+ Sbjct: 1093 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1152 Query: 255 ------EQLSS-ANHSLQLASQIQKAPDVEQAIEVL--TRSSLEVELAAKEREIAQLVED 305 +QLS+ +++LA ++ ++ D + + L RS L +L ++ ++ ++D Sbjct: 1153 AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKD 1212 Query: 306 VQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG-QADYEEVKKELNILKSM 364 +ASL K IS L+ K++ L++L ++ + + K ++++++ Sbjct: 1213 ADEEKASLQK-------SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTL 1265 Query: 365 EFAPSEGAGTQDAAKPLEVLLLEKNRSLQSEN 396 E S+ + K LE+ L E R L S + Sbjct: 1266 E---SDKVKLELKVKNLELQLKENKRQLSSSS 1294 Score = 43.9 bits (102), Expect = 0.001 Identities = 58/253 (22%), Positives = 108/253 (42%), Gaps = 49/253 (19%) Query: 7 ARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 66 A+L+ ELD +E +S++ L ++++ E+ RK++ L ++ + Sbjct: 1106 AKLQNELDTLKENNLKNVEELNKSKELLTVENQKM-----EEFRKEIETLKQAAAQKSQQ 1160 Query: 67 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 126 LS +E NV +L ++ R D T +QKL E N Sbjct: 1161 LSALQEE------NV------------------KLAEELGRSRDEVTSHQKLEEERSVLN 1196 Query: 127 KEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE-----QKLQNDFA------EK 175 + E+K +E K +K+ E K+ + T AL E +KL+N+ Sbjct: 1197 NQLLEMKKRE--SKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS 1254 Query: 176 ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELF----DLKTKYDEETTAKADEIEM 231 + L + S + E KV++L+ L++ + +L + T+ DE+ A+ +I+ Sbjct: 1255 AKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDF 1314 Query: 232 ---IMTDLERANQ 241 ++ DL+R NQ Sbjct: 1315 LNSVIVDLQRKNQ 1327 >gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens] Length = 284 Score = 73.9 bits (180), Expect = 1e-12 Identities = 74/291 (25%), Positives = 139/291 (47%), Gaps = 26/291 (8%) Query: 64 IDALSKRSKEAEAAFLNVYKRLIDVP-DPVPALDLGQQLQLKV----QRLHDIETENQKL 118 +DA+ K+ + + N R D A D +QL+ ++ ++L E E K Sbjct: 1 MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKY 60 Query: 119 RETLEEYNK--EFAEVK--NQEVTIKALKEKIREYEQTLKNQAETIA--LEKEQKLQNDF 172 E L++ + E AE K + E + +L +I+ E+ L E +A L+K ++ + Sbjct: 61 SEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120 Query: 173 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 232 E ER ++ + S+ ++ E K++ + L++ + D KY+E A ++ +I Sbjct: 121 DESERGMKVIE----SRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEV----ARKLVII 172 Query: 233 MTDLERANQRAEVAQREAETLREQLSSANHSL-----QLASQIQKAPDVEQAIEVLTRSS 287 +DLERA +RAE+++ + L E+L + ++L Q QK E+ I+VL+ Sbjct: 173 ESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKL 232 Query: 288 LEVELAAK--EREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNS 336 E E A+ ER + +L + + L+ + +E + S L+Q L N+ Sbjct: 233 KEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNN 283 Score = 48.9 bits (115), Expect = 4e-05 Identities = 51/227 (22%), Positives = 107/227 (47%), Gaps = 21/227 (9%) Query: 153 LKNQAETIALEKEQKLQN-DFAEKERKLQETQMSTTS-KLEEAEHKVQSLQTALEKTRTE 210 +K + + + L+KE L + AE ++K E + +L + K++ + L+K Sbjct: 4 IKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEA 63 Query: 211 LFDLKTKYD----EETTAKAD------EIEMIMTDLERANQRAEVAQREAETLREQLSSA 260 L D + K + + T A+AD I+++ +L+RA +R A ++ E + + Sbjct: 64 LKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADES 123 Query: 261 NHSLQ-LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLREN 319 ++ + S+ QK + + E+ + + + A +R+ ++ + +++ L + E Sbjct: 124 ERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDA-DRKYEEVARKLVIIESDLERAEER 182 Query: 320 ---SASQISQLEQQLSAKNSTLKQLE---EKLKGQAD-YEEVKKELN 359 S + ++LE++L + LK LE EK + D YEE K L+ Sbjct: 183 AELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLS 229 >gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo sapiens] Length = 1940 Score = 73.6 bits (179), Expect = 1e-12 Identities = 148/756 (19%), Positives = 310/756 (41%), Gaps = 71/756 (9%) Query: 9 LKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTP-----EDLRKQVAPLLKSFQGE 63 L+ ++ A + L + ++ +Q K + + K+ T E++ ++ + + E Sbjct: 888 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 947 Query: 64 IDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLE 123 L K + E V K + V +L ++L + + + E + L+E + Sbjct: 948 CSELKKDIDDLELTLAKVEKEKHATENKVK--NLTEELSGLDETIAKLTREKKALQEAHQ 1005 Query: 124 EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ 183 + + +++ ++ K K+ + + L++ +LE+E+KL+ D +RKL+ Sbjct: 1006 QALDDLQAEEDKVNSLNKTKSKLEQQVEDLES-----SLEQEKKLRVDLERNKRKLEGDL 1060 Query: 184 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETT------AKADEIEMIMTDLE 237 + + E+ Q L L+K E L++K ++E T K E++ + +LE Sbjct: 1061 KLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELE 1120 Query: 238 RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAK-E 296 + AE A R A+T +++ A +L+ ++++A V +S ++EL K E Sbjct: 1121 EEIE-AERATR-AKTEKQRSDYARELEELSERLEEAGGV---------TSTQIELNKKRE 1169 Query: 297 REIAQLVEDVQRL----QASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 352 E +L D++ +A + LR+ A +++L +Q+ L+++++KL + + Sbjct: 1170 AEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI----DNLQRVKQKL--EKEKS 1223 Query: 353 EVKKELNIL-KSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSAR 411 E K E++ L SME A + + LE L E + +N ++ S S+L+ Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE----ARGKNEEIQRSLSELTTQKS 1279 Query: 412 RKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLP 471 R + E R SQL R+ + + T T + ++ ++LA Sbjct: 1280 RLQTEAGELSRQLEEKESIVSQLSRS---KQAFTQQTEELKRQLEEENKAKNALAHALQS 1336 Query: 472 LASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD--V 529 + Q ++ +A+ +A S + T Y T++I L+++ Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT-KYETDAIQRTEELEEAKKKLA 1395 Query: 530 NGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEI 589 + S Q E+ + E + +V++ ++ + L Q + ++ Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAA--ALDKKQRNFDKV 1453 Query: 590 LARPKPWNKLTVRGKEPFHKMKQFLSDEQNIL------ALRSIQGRQRENPG--QSLNRL 641 LA K + + E K + LS E L AL ++ +REN Q + L Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADL 1513 Query: 642 FQEVPKRRNG--------SEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQP 693 +++ + NG S I + +EA ++ + + L++Q + Sbjct: 1514 TEQIAE--NGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKS 1571 Query: 694 SSASGSGNSDDAIRSILQQARREMEAQQAALDPALK 729 D+ I + + +R +E Q+ALD ++ Sbjct: 1572 EIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR 1607 Score = 58.5 bits (140), Expect = 5e-08 Identities = 69/312 (22%), Positives = 132/312 (42%), Gaps = 18/312 (5%) Query: 108 LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQK 167 L ETE + + EE+ K E+ E K L+EK+ TL + + L+ + + Sbjct: 841 LKSAETEKE-MATMKEEFQKTKDELAKSEAKRKELEEKL----VTLVQEKNDLQLQVQAE 895 Query: 168 LQN--DFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK 225 +N D E+ +L + + +K++E + + E+ EL K K ++E + Sbjct: 896 SENLLDAEERCDQLIKAKFQLEAKIKEVTERAED----EEEINAELTAKKRKLEDECSEL 951 Query: 226 ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV--EQAIEVL 283 +I+ + L + + + + + L E+LS + ++ ++ +KA +QA++ L Sbjct: 952 KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDL 1011 Query: 284 TRSSLEVELAAKER-EIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE 342 +V K + ++ Q VED++ KLR + +LE L ++ LE Sbjct: 1012 QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLE 1071 Query: 343 EKLKGQADYEEVKKEL---NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 399 K Q D KK+ + +E + G Q K L+ + E +++E A Sbjct: 1072 ND-KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATR 1130 Query: 400 RISNSDLSGSAR 411 + S AR Sbjct: 1131 AKTEKQRSDYAR 1142 Score = 51.6 bits (122), Expect = 6e-06 Identities = 50/209 (23%), Positives = 90/209 (43%), Gaps = 18/209 (8%) Query: 50 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 109 +K++ L Q E++ S+ ++ AE K + D L Q ++R+ Sbjct: 1728 KKKLETDLMQLQSEVEDASRDARNAEE---KAKKAITDAAMMAEELKKEQDTSAHLERMK 1784 Query: 110 -DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKL 168 ++E + L+ L+E E +K + I+ L+ +IRE E LE EQK Sbjct: 1785 KNLEQTVKDLQHRLDE--AEQLALKGGKKQIQKLETRIRELE---------FELEGEQKK 1833 Query: 169 QNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKY---DEETTAK 225 + + RK + T + EE V LQ ++K + ++ K + DE+ A Sbjct: 1834 NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAH 1893 Query: 226 ADEIEMIMTDLERANQRAEVAQREAETLR 254 + +LE A +RA++A+ + LR Sbjct: 1894 LTKFRKAQHELEEAEERADIAESQVNKLR 1922 Score = 48.5 bits (114), Expect = 5e-05 Identities = 84/356 (23%), Positives = 160/356 (44%), Gaps = 52/356 (14%) Query: 21 ANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA-LSKRSKEAEAAFL 79 + +Q E E++ +L + E E ++ L + EID ++++ +E E Sbjct: 1530 SRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR 1589 Query: 80 NVYKRLIDVPDPVPALDL-----GQQLQLKVQR---LHDIETE----NQKLRETLEEYNK 127 N Y+R ++ ALD + ++LK + L++IE + N++ ETL+ Sbjct: 1590 N-YQRTVETMQS--ALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRS 1646 Query: 128 EFAEVKNQEVTIK-ALK--EKIREYEQTLKNQAETIALEKEQ-KLQNDFAEKERKLQETQ 183 ++K+ ++ + AL+ E ++E ++ +A + E E+ + + E+ RKL E + Sbjct: 1647 VQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQE 1706 Query: 184 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA 243 L ++ +VQ L T T L K K + + E+E D A ++A Sbjct: 1707 ------LLDSNERVQLLHTQ----NTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKA 1756 Query: 244 EVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVE-LAAKEREIAQL 302 + A +A + E+L + +++K ++EQ ++ L E E LA K + Sbjct: 1757 KKAITDAAMMAEELKKEQDTSAHLERMKK--NLEQTVKDLQHRLDEAEQLALKGGK---- 1810 Query: 303 VEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358 + +Q+L+ T++RE LE +L + K+ E +KG YE KEL Sbjct: 1811 -KQIQKLE---TRIRE--------LEFELEGEQ---KKNTESVKGLRKYERRVKEL 1851 >gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens] Length = 284 Score = 72.8 bits (177), Expect = 2e-12 Identities = 75/291 (25%), Positives = 142/291 (48%), Gaps = 26/291 (8%) Query: 64 IDALSKRSKEAEAAFLNVYKRLIDVP-DPVPALDLGQQLQLKV----QRLHDIETENQKL 118 +DA+ K+ + + N R D A D +QL+ ++ ++L E E K Sbjct: 1 MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKY 60 Query: 119 RETLEEYNK--EFAEVK--NQEVTIKALKEKIREYEQTLKNQAETIA--LEKEQKLQNDF 172 E L++ + E AE K + E + +L +I+ E+ L E +A L+K ++ + Sbjct: 61 SEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120 Query: 173 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 232 E ER ++ + S+ ++ E K++ + L++ + D KY+E A ++ +I Sbjct: 121 DESERGMKVIE----SRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEV----ARKLVII 172 Query: 233 MTDLERANQRAEVAQREAETLREQLSSANHSLQ--LASQ---IQKAPDVEQAIEVLTRSS 287 +DLERA +RAE+++ + L EQL + +L+ +A++ QK E+ I+VL+ Sbjct: 173 ESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKL 232 Query: 288 LEVELAAK--EREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNS 336 E E A+ ER + +L + + L+ + +E + S L+Q L N+ Sbjct: 233 KEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNN 283 Score = 53.5 bits (127), Expect = 1e-06 Identities = 54/227 (23%), Positives = 108/227 (47%), Gaps = 21/227 (9%) Query: 153 LKNQAETIALEKEQKLQN-DFAEKERKLQETQMSTTS-KLEEAEHKVQSLQTALEKTRTE 210 +K + + + L+KE L + AE ++K E + +L + K++ + L+K Sbjct: 4 IKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEA 63 Query: 211 LFDLKTKYD----EETTAKAD------EIEMIMTDLERANQRAEVAQREAETLREQLSSA 260 L D + K + + T A+AD I+++ +L+RA +R A ++ E + + Sbjct: 64 LKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADES 123 Query: 261 NHSLQ-LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLREN 319 ++ + S+ QK + + E+ + + + A +R+ ++ + +++ L + E Sbjct: 124 ERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDA-DRKYEEVARKLVIIESDLERAEER 182 Query: 320 ---SASQISQLEQQLSAKNSTLKQL---EEKLKGQAD-YEEVKKELN 359 S Q+ QLE+QL + TLK L E+K + D YEE K L+ Sbjct: 183 AELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLS 229 >gi|87298937 centrosomal protein 110kDa [Homo sapiens] Length = 2325 Score = 72.4 bits (176), Expect = 3e-12 Identities = 102/467 (21%), Positives = 203/467 (43%), Gaps = 67/467 (14%) Query: 10 KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLK---SFQGEIDA 66 +++L T VLA ++ S+ + L + +K L++++ L + S +I A Sbjct: 1800 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK-----LQQELDQLNRDKLSLHNDISA 1854 Query: 67 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIE-TENQKLRETLEEY 125 + ++ +E A ++ + L +V D L+L +Q L + D+ +E +L++ + E+ Sbjct: 1855 MQQQLQEKREAVNSLQEELANVQDH---LNLAKQDLLHTTKHQDVLLSEQTRLQKDISEW 1911 Query: 126 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185 F + + +E T + ++ Q LQN+ E + KL + +M Sbjct: 1912 ANRFEDCQKEEETKQ----------------------QQLQVLQNEIEENKLKLVQQEM- 1948 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEV 245 + + + +S ++ LE ++ L + + + ++E T + +++ +++ + A +R Sbjct: 1949 ---MFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRT 2005 Query: 246 AQRE---AETLREQLSSANHSLQLASQ-----------IQKAPDVEQAIEVLTRSSLEVE 291 Q E E+L + LS L Q +QK D +A L R+ E Sbjct: 2006 LQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTE 2065 Query: 292 LAAKEREIAQLVE--DVQRLQAS---LTKLRENSASQISQLEQQLSAKNS---TLKQLEE 343 E+++A L E +QR Q L + +ENS Q +L A+++ + ++E Sbjct: 2066 RKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKE 2125 Query: 344 KLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR-SLQSENAALRIS 402 + Q +Y E+KK++ K +E E DA + L+ + ++ R SL++ N L Sbjct: 2126 LNQMQYEYTELKKQMANQKDLERRQME---ISDAMRTLKSEVKDEIRTSLKNLNQFLPEL 2182 Query: 403 NSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTH 449 +DL R + E SL P + P E+ N + H Sbjct: 2183 PADLEAILERNENLEGELE---SLKENLPFTMNEGPFEEKLNFSQVH 2226 Score = 70.1 bits (170), Expect = 2e-11 Identities = 77/359 (21%), Positives = 161/359 (44%), Gaps = 42/359 (11%) Query: 10 KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAP-----LLKSFQGEI 64 ++++ A T L+ DE E++ ++++ + EFK+ K+++ L K G + Sbjct: 443 EKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRL 502 Query: 65 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEE 124 ++K +EA L + K+ Q++ K + + D++ L + Sbjct: 503 QLVNKLRQEALDLELQMEKQ-------------KQEIAGKQKEIKDLQIAIDSLDSKDPK 549 Query: 125 YNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQM 184 ++ A+ +E + + ++ ++ E L IA E E + + E +L E Q+ Sbjct: 550 HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE-----EIKDLEEQLTEGQI 604 Query: 185 STTSKL-EEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI---MTDLERAN 240 + L ++ E + LQ L + + T+ E DE E + +T++E+ Sbjct: 605 AANEALKKDLEGVISGLQEYLGTIKGQ----ATQAQNECRKLRDEKETLLQRLTEVEQER 660 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300 + E+ +AE +R++L+ +LQ ++ + Q + LE L ++ E Sbjct: 661 DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN 720 Query: 301 QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELN 359 QL E+++++ LT+L E SA Q ++LE++ A + L G+A + E K++ N Sbjct: 721 QLKEELEKV-TRLTQL-EQSALQ-AELEKERQALKNAL--------GKAQFSEEKEQEN 768 Score = 55.8 bits (133), Expect = 3e-07 Identities = 75/373 (20%), Positives = 160/373 (42%), Gaps = 46/373 (12%) Query: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLR--KQVAPLLKSFQGEIDALSKR- 70 D+ L+ ++++ + ++L + ++N L+ K+ LL++ + E++ L + Sbjct: 1530 DSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQV 1589 Query: 71 -SKEAEAAFLN------------VYKRLIDVP-DPVPALDLGQ-QLQLKVQRLHDIETEN 115 S++ E A L+ + ++ D AL LG+ ++ K + ++++ Sbjct: 1590 TSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLL 1649 Query: 116 QKLRETLEEYNKEFAEVKNQEVTIKALKEKIRE-----------YEQTLKNQAETIALEK 164 ++L E N + +E K Q IK EK E ++ LKN + + LE Sbjct: 1650 EELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLEN 1709 Query: 165 EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTA 224 + LQ + ++++ E + + + LEE + ++++LQ ++ + E+ K + + Sbjct: 1710 HE-LQGLKLQHDQRVSELEKTQVAVLEE-KLELENLQQISQQQKGEIEWQKQLLERDKR- 1766 Query: 225 KADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLT 284 EIE + + E +E E L+E+ L ++ A + +E Sbjct: 1767 ---EIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823 Query: 285 RSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEK 344 LE+ + ++E+ QL D L + IS ++QQL K + L+E+ Sbjct: 1824 LEKLELNVRKLQQELDQLNRDKLSLH-----------NDISAMQQQLQEKREAVNSLQEE 1872 Query: 345 LKGQADYEEVKKE 357 L D+ + K+ Sbjct: 1873 LANVQDHLNLAKQ 1885 Score = 54.7 bits (130), Expect = 7e-07 Identities = 79/366 (21%), Positives = 154/366 (42%), Gaps = 63/366 (17%) Query: 25 DESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKR 84 DE E K L+++ E + + LL + E+ +++K A F + + Sbjct: 1419 DEIECIEKTLLKRRSELR---------EADRLLAEAESELSCTKEKTKNAVEKFTDAKRS 1469 Query: 85 LIDVPDPVPALD------------LGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEV 132 L+ L+ QQL+ D+E K E L+E NK A Sbjct: 1470 LLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAK 1529 Query: 133 KNQEVTIKALKEKIREYEQTLKNQAE----------TIALEKEQKLQNDFAEKER----- 177 + + KEK+ E Q L+ E + E E LQ AE E+ Sbjct: 1530 DSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQV 1589 Query: 178 KLQETQMSTTSK-LEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 236 Q+ +M+ + L + ++ LQ ++ + + +L + + E T K + I + + L Sbjct: 1590 TSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLL 1649 Query: 237 ERANQRAEVAQREAETLREQLSSANHSLQLASQ-IQKAPDVEQAIEVLTRSSLEVELAAK 295 E E++ ++ E L Q+S L L Q I+K E+ ++V+ R +++ Sbjct: 1650 E------ELSFQKGE-LNVQISERKTQLTLIKQEIEKE---EENLQVVLR-----QMSKH 1694 Query: 296 EREIAQLVEDVQRLQASLTKLR--------ENSASQISQLEQQLSAKNSTLKQLEEKLKG 347 + E+ +++ +Q L L+ E +Q++ LE++L +N L+Q+ ++ KG Sbjct: 1695 KTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN--LQQISQQQKG 1752 Query: 348 QADYEE 353 + ++++ Sbjct: 1753 EIEWQK 1758 Score = 52.8 bits (125), Expect = 3e-06 Identities = 74/344 (21%), Positives = 150/344 (43%), Gaps = 44/344 (12%) Query: 28 EQSRKRLIEQSREFKKNTPED-LRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLI 86 ++ R++L + E ++P D L K +A L K F + L++ E + A + K Sbjct: 814 DELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFS---EILARSKWERDEAQVRERK--- 867 Query: 87 DVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKI 146 L +++ L+ ++L + E ++ E E F + + E I+ ++ +I Sbjct: 868 ----------LQEEMALQQEKLATGQEEFRQACERALEARMNF-DKRQHEARIQQMENEI 916 Query: 147 REYEQTLKNQAETIALEKEQKLQNDFAEKERKL-QETQMSTTSKLEEAEHKVQ--SLQTA 203 ++ LK+ E L Q LQ EKER L Q ++ KLE+A+ + Q L Sbjct: 917 HYLQENLKSMEEIQGLTDLQ-LQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE 975 Query: 204 LEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQ-RAEVAQ------REAETLREQ 256 L+K + + E T D+++ + + + NQ RAE Q R+A Sbjct: 976 LKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARD 1035 Query: 257 LSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKL 316 L+ A ++L + + + +E + ++ + ++ EI +L E ++R + + +L Sbjct: 1036 LTRAEAEIELLQNLLRQKGEQFRLE-MEKTGVGTGANSQVLEIEKLNETMERQRTEIARL 1094 Query: 317 R--------------ENSASQISQLEQQLSAKNSTLKQLEEKLK 346 + EN +I++L +++S +N + + + K Sbjct: 1095 QNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFK 1138 Score = 52.4 bits (124), Expect = 3e-06 Identities = 64/336 (19%), Positives = 149/336 (44%), Gaps = 44/336 (13%) Query: 104 KVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE 163 K Q ++E + + + L+E EV+ T++ +++ + +++ + +E Sbjct: 1349 KRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIE 1408 Query: 164 KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDE--- 220 K K D ++ +++T + S+L EA+ + ++ L T+ + + K+ + Sbjct: 1409 KSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKR 1468 Query: 221 ---ETTAKADEIEM----IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKA 273 +T + A+E+E +L +A+Q+ Q +A+ L + L+ ++I A Sbjct: 1469 SLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAA 1528 Query: 274 PD---------VEQAIEVLTRSSLEVELAAK-EREIAQLVED----VQRLQASLTKLREN 319 D E+ E L + ++E+A + E Q++++ +Q +A L KL+ Sbjct: 1529 KDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQ 1588 Query: 320 SASQ---ISQLEQQLSAKNSTLKQLE-EKLKGQADYEE---------------VKKELNI 360 SQ ++ L++QL K L L+ ++ +AD +E +++ ++ Sbjct: 1589 VTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSL 1648 Query: 361 LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSEN 396 L+ + F E Q + + ++ L+++ + EN Sbjct: 1649 LEELSFQKGE-LNVQISERKTQLTLIKQEIEKEEEN 1683 Score = 49.7 bits (117), Expect = 2e-05 Identities = 74/370 (20%), Positives = 164/370 (44%), Gaps = 36/370 (9%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67 RL++++ A + Q E E +++L E ++N + +++++ + + Q E Sbjct: 1903 RLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEM--MFQRLQKE---- 1956 Query: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127 +E+E + L K + +L Q Q L + +++R TL+E Sbjct: 1957 ----RESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVR-TLQE--- 2008 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTL-KNQAETIALEKE-QKLQNDFAEKERKLQETQMS 185 E ++ E T+ K ++ E EQ L + E +AL+KE ++ DF+ L Q Sbjct: 2009 EERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFS-----LLRNQFL 2063 Query: 186 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEV 245 T K +AE +V SL+ AL+ R++L + +E + E+ I + ++RA Sbjct: 2064 TERK--KAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARR 2121 Query: 246 AQREAETLREQLSSANHSLQLASQIQKAP-DVEQAIEVLTRSSLEVELAAKEREIAQLVE 304 +E ++ + + + +++ ++ A+ L +S ++ E+ + + Q + Sbjct: 2122 LMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL-KSEVKDEIRTSLKNLNQFLP 2180 Query: 305 DV-----------QRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEE 353 ++ + L+ L L+EN +++ + S + ++E +G+A E+ Sbjct: 2181 ELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREK 2240 Query: 354 VKKELNILKS 363 ++ + LK+ Sbjct: 2241 LRHREDRLKA 2250 Score = 40.4 bits (93), Expect = 0.013 Identities = 74/328 (22%), Positives = 139/328 (42%), Gaps = 51/328 (15%) Query: 93 PALDLGQQLQLKVQRLHDIET-ENQKL----------RETLEEYNKEFAEVKNQEVTIKA 141 P + L LQ + L +E+ E Q + R +LEE + +++ + + + Sbjct: 229 PVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEE 288 Query: 142 LKEKIREYEQTLKNQ-------AETIALEKE--QKLQNDFAEKERKLQETQMSTTS---- 188 LK K + + +KNQ E L+K+ ++L++D K L++ + T Sbjct: 289 LKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQK 348 Query: 189 ----KLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER----AN 240 + E A +K+ + L +E ++ DE + M E + Sbjct: 349 QYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSA 408 Query: 241 QRAEVAQREA-ETLREQLSSANHSLQLASQIQKAPDVEQAIEVL-TR-SSLEVELAAKER 297 Q ++ + E E LR + L +Q++ D E+ I TR S L E+ E+ Sbjct: 409 QAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLE---DKEKKISAAQTRLSELHDEIEKAEQ 465 Query: 298 EIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKE 357 +I + E+ ++L+ ++ +L++ S + L +QLS + QL KL+ +A Sbjct: 466 QILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLSGR----LQLVNKLRQEA-------- 512 Query: 358 LNILKSMEFAPSEGAGTQDAAKPLEVLL 385 L++ ME E AG Q K L++ + Sbjct: 513 LDLELQMEKQKQEIAGKQKEIKDLQIAI 540 Score = 35.0 bits (79), Expect = 0.55 Identities = 53/241 (21%), Positives = 99/241 (41%), Gaps = 40/241 (16%) Query: 17 ATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPL--LKSFQGEI-DALSKRSKE 73 AT+ QD E++R+ + E ++ + T +L+KQ+A L+ Q EI DA+ E Sbjct: 2106 ATIELVAQDNHERARRLMKELNQMQYEYT--ELKKQMANQKDLERRQMEISDAMRTLKSE 2163 Query: 74 AEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETL----------E 123 + K L +PA L+ ++R ++E E + L+E L E Sbjct: 2164 VKDEIRTSLKNLNQFLPELPA-----DLEAILERNENLEGELESLKENLPFTMNEGPFEE 2218 Query: 124 EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ 183 + N + ++ +AL+EK+R E LK Q L++ +++ L + + Sbjct: 2219 KLNFSQVHIMDEHWRGEALREKLRHREDRLKAQ-----------LRHCMSKQAEVLIKGK 2267 Query: 184 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA 243 T L +V +L + T D ++ ++E +T+ + Q Sbjct: 2268 RQTEGTLHSLRRQVDALGELVTSTSA---------DSASSPSLSQLESSLTEDSQLGQNQ 2318 Query: 244 E 244 E Sbjct: 2319 E 2319 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 71.2 bits (173), Expect = 7e-12 Identities = 103/463 (22%), Positives = 184/463 (39%), Gaps = 69/463 (14%) Query: 8 RLKRELDATATVLANRQDESEQS---------RKRLIEQSREFKKNTPEDLRKQVAPLLK 58 RL EL+ ATV+ + + E Q +K L++ T E R+ + Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES-----E 249 Query: 59 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKL 118 + E L + +EA + L P V Q+LQ ++++ +NQ L Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV--QELQKLKSSVNELTQKNQTL 307 Query: 119 RETL-----------EEYNKEFAEVKNQEVTI-------KALKEKIREYEQTLKNQAETI 160 E L E++N+E KN + T+ + L+ ++ E +L + Sbjct: 308 TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL 367 Query: 161 ALEKE--QKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQ---SLQTALEKTRTELFDLK 215 + + E QKL+ + +E E K Q + ++ E K Q LQ+ + + ++L + + Sbjct: 368 SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427 Query: 216 TKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSS-ANHSLQLASQIQKAP 274 + E ++ ++ L Q+ Q + L EQL +S +L Q+ K Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487 Query: 275 DVEQAIEVLTRSSL------EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLE 328 Q + L +S+ + +L R+I + +Q L+A L K +EN + + E Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547 Query: 329 Q----------------QLSAKNSTLK----QLEEKLKGQADYEEVKKELNILKSMEFAP 368 QL KN TL+ QL EKLK Q++ + +E N+ ++ Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE-NLHDQVQEQK 606 Query: 369 SEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSAR 411 + QD LE + E N L ++S D+ A+ Sbjct: 607 AHLRAAQDRVLSLETSVNELNSQLNESKE--KVSQLDIQIKAK 647 Score = 70.5 bits (171), Expect = 1e-11 Identities = 90/433 (20%), Positives = 183/433 (42%), Gaps = 58/433 (13%) Query: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFK--KNTPEDLRKQVAPLLKSFQGEID 65 ++ +LD L ++Q+ Q L E ++ + E+L Q+ L E D Sbjct: 685 KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL------EAD 738 Query: 66 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125 +L ++ + +A +R ++ + A +L +QL+++ + + + QK E LE Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798 Query: 126 NKEFAEVKNQEVTIK----ALKEKIREYEQTLKNQAET-------IALEKE--------- 165 ++ + + ++ +K L ++ + + L N+ +T + +EKE Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858 Query: 166 --------QKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTK 217 L+N +E E++ Q+ + + + + LQ +E T E +LK Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918 Query: 218 YDEETTAKAD---EIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAP 274 ++E A E+ + L +A + ++E + L+ ++ S + + +A Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978 Query: 275 DVEQAIEVLTRSSLE-----------VELAAKEREIAQLVEDVQRLQASLTKLRENSASQ 323 E I VL ++ LE ELAA++ +I+ L + ++ Q + +L+ S Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ----SD 1034 Query: 324 ISQLEQQLSAKNSTLKQLEEKLK-GQADYEEVKKELNILKSM--EFAPSEGAGTQDAAKP 380 E +L A LK +EEKL Q D + ++ + E ++ QD+AK Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK 1094 Query: 381 LEVLLLEKNRSLQ 393 E L E+ ++LQ Sbjct: 1095 -EQQLQERCKALQ 1106 Score = 68.9 bits (167), Expect = 3e-11 Identities = 95/410 (23%), Positives = 184/410 (44%), Gaps = 58/410 (14%) Query: 23 RQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVY 82 +Q+E +Q K+ E + K E+L ++ + Q K KEA L+ Sbjct: 804 KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV-----KMEKEALMTELSTV 858 Query: 83 K-RLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQ-----E 136 K +L V D LK + + E ENQK + + + K E+K+Q E Sbjct: 859 KDKLSKVSD-----------SLKNSK-SEFEKENQKGKAAILDLEKTCKELKHQLQVQME 906 Query: 137 VTIKALKE--KIREYEQTLKNQAETIALEKEQKL---QNDFAEKERKLQETQMSTTSKLE 191 T+K KE K E E+ +Q + +++L QN + E++ Q+ Q + + Sbjct: 907 NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966 Query: 192 EAEHK---VQSLQ-----TALEKTRTE--LFDLKTKYDEETTAKADEIEMIMTDLERANQ 241 +E K +++LQ L+KT E L T+ +E A+ ++I ++ + E++ + Sbjct: 967 SSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026 Query: 242 RAEVAQ-----REAETL--REQLSSANHSLQLA--------SQIQKAPDVEQAIEVLTRS 286 + Q RE+E L R+ L S L LA +QI + Q ++ ++ Sbjct: 1027 TFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT-AKA 1085 Query: 287 SLEVELAAKEREI---AQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEE 343 +LE + A KE+++ + ++D+Q+ ++ K N S+++++E+ + + +L E Sbjct: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145 Query: 344 KLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQ 393 +LK E +K+ N+ + + + Q A L+ + ++ R+ Q Sbjct: 1146 ELKSH-KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQ 1194 Score = 63.2 bits (152), Expect = 2e-09 Identities = 149/709 (21%), Positives = 279/709 (39%), Gaps = 122/709 (17%) Query: 98 GQQLQLKVQRLHD--IETENQ--KLRETLEEYNKEFAE-VKNQEVTIKALKEKIREYEQT 152 G QLQ ++ +LH +ETE Q + L+E + +E + ++E + L+ K+ E+ Sbjct: 409 GLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ 468 Query: 153 LKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEH--------------KVQ 198 LK + T + E + +L ++ ++ Q Q STT+KL EA++ K+Q Sbjct: 469 LKEKV-TNSTELQHQLDKT-KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526 Query: 199 SLQ----------TALEKTRTELFDLKTKYDEETTAKADEI--------EMIMTDLERAN 240 +L+ + LEK R +L+ K + E TA +++ E + E+ Sbjct: 527 NLEALLQKSKENISLLEKEREDLY-AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK 585 Query: 241 QRAEVAQREAETLREQLSSANHSL---------------QLASQIQKAPDVEQAIEVLTR 285 ++E ++ E L +Q+ L +L SQ+ ++ + +++ + Sbjct: 586 NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645 Query: 286 SSLEVELAAKEREIAQLVEDVQRLQASLTKLRENS------ASQISQLEQQLSAKNSTLK 339 + E+ L+A+ + AQ + L + L++ +Q+ Q+ +L K Sbjct: 646 AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705 Query: 340 QLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 399 QLE LK +Y+E K L++ + E EG + A LEV K ++LQ Sbjct: 706 QLESHLK---EYKE--KYLSLEQKTE--ELEGQIKKLEADSLEV-KASKEQALQDLQQQR 757 Query: 400 RISNSDLSGSARRKGKD---QPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGL 456 ++ N+DL A K + E L S+ + ++ + Q L Sbjct: 758 QL-NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQI----L 812 Query: 457 SQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNS 516 QDF + S + LN+ +Q + + K +EA T + ST + Sbjct: 813 KQDFETLSQET------KIQHEELNNRIQTTVTELQKVKMEKEALMTEL--STVKDKLSK 864 Query: 517 ISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGH 576 +S + + S S+ E + +D + +++K QL Sbjct: 865 VS-----------DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL------------ 901 Query: 577 YVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQ 636 Q + L K K + KE H++K L+ Q L +Q E Q Sbjct: 902 ------QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955 Query: 637 SL----NRLFQEVPKRRNGSE---GNITTRIRASETGSDEAIKSILEQAKRELQVQKTAE 689 L N L Q +++ E G + + +T + ++ L QA +EL +K Sbjct: 956 QLQGNINELKQSSEQKKKQIEALQGELKIAV-LQKTELENKLQQQLTQAAQELAAEKEKI 1014 Query: 690 PAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDI 738 ++ S + ++S E+ A + L ++ L+Q D+ Sbjct: 1015 SVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063 Score = 58.5 bits (140), Expect = 5e-08 Identities = 68/290 (23%), Positives = 132/290 (45%), Gaps = 43/290 (14%) Query: 89 PDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVT-IKALKEKIR 147 P + +L +L + +HD ++ E+ ++ + QEV ++A ++ + Sbjct: 44 PQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEK 103 Query: 148 EYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ---MSTTSKLEEAEHK---VQSLQ 201 Y + LK + LEK Q LQ A+ + + ++ S +LEEA+ + ++ ++ Sbjct: 104 WYSEELKKE-----LEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMK 158 Query: 202 TALEKTR----TELFDLKTKYDEETTAK-----------------ADEIEMIMTDLERAN 240 E+ TE+ D+K+KYDEE + + A I+ + T+L + Sbjct: 159 DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRP 218 Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPD------VEQAIEVLTRSSLEVELAA 294 +VA + E ++ Q N +L+ + +K D + A T S L ELA Sbjct: 219 GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAK 278 Query: 295 KEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEK 344 +E+A V+++Q+L++S+ +L + + + L + L K +LEEK Sbjct: 279 GPQEVAVYVQELQKLKSSVNELTQKNQT----LTENLLKKEQDYTKLEEK 324 Score = 55.8 bits (133), Expect = 3e-07 Identities = 141/714 (19%), Positives = 288/714 (40%), Gaps = 88/714 (12%) Query: 24 QDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGE---IDALSKRSKEAEAAFLN 80 +D+ Q+ + L+++S+E + E R+ + +++ +GE ++ L +++ + Sbjct: 521 KDQKIQNLEALLQKSKE-NISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQ 579 Query: 81 VYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQ--KLRETLEEYNKEFAEVKNQ--- 135 + ++L + + Q++ Q+ H +++ L ++ E N + E K + Sbjct: 580 LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ 639 Query: 136 -EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMST---TSKLE 191 ++ IKA E L AE + LQN + LQ+ Q T++L+ Sbjct: 640 LDIQIKAKTE--------LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD 691 Query: 192 EAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAE 251 + K+Q Q + + L + K KY K +E+E + LE + + ++ +A Sbjct: 692 QVTAKLQDKQEHCSQLESHLKEYKEKY-LSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750 Query: 252 TLREQLSSANHSLQL-ASQIQKAPDVEQAIEVLTRSSLEVELAAKE---REIAQLVEDVQ 307 +Q N L+L A+++ K ++E+ I TR L+ + A E +++ + E+ Q Sbjct: 751 QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810 Query: 308 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE-EKLKGQADYEEVKKELN-ILKSME 365 L+ L + + Q +L ++ + L++++ EK + VK +L+ + S++ Sbjct: 811 ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870 Query: 366 FAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGS 425 + SE K +L LEK +++ N+ L K + E Sbjct: 871 NSKSEFEKENQKGK-AAILDLEKTCKELKHQLQVQMENT-LKEQKELKKSLEKEKEASHQ 928 Query: 426 LPAPPPSQ----------LPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLAST 475 L S L +N E+ ++ + + +L L +A Sbjct: 929 LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG-ELKIAVL 987 Query: 476 GKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPS 535 K L + LQ+QL Q A QE + S N SQ +Q Sbjct: 988 QKTELENKLQQQLTQ-----AAQELAAEKEKISV--LQNNYEKSQETFKQ---------- 1030 Query: 536 PSQSESAGSVSEGEEMDTAEIARQVKEQLI---------KHNIGQRIFGHYVLGLSQGSV 586 QS+ G E E + T + + V+E+L ++ IG + L ++ ++ Sbjct: 1031 -LQSDFYG--RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1087 Query: 587 SEILARPKPWNKLTVRG-----KEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRL 641 + A+ + + + KE K K+ ++++ + + I+ RQ + + +L Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQE----KEITKL 1143 Query: 642 FQEVPKRRNGSEGNITTRIRASE---------TGSDEAIKSILEQAKRELQVQK 686 +E+ + S IT A + G +++K+ +EQ KR Q+ K Sbjct: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILK 1197 Score = 43.5 bits (101), Expect = 0.002 Identities = 67/321 (20%), Positives = 138/321 (42%), Gaps = 43/321 (13%) Query: 15 ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEA 74 A +++NR Q++ LI++ + K +D K+ L + + D ++S + Sbjct: 1059 AQEDLISNRNQIGNQNK--LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK- 1115 Query: 75 EAAFLNVYKRLIDVPDPVPALDLGQQLQ-------LKVQRLHDIETENQKLRETLEEYNK 127 E +N +L ++ + + Q+ + LK +L I+ E L++ + + Sbjct: 1116 EKELVNEKSKLAEIEE----IKCRQEKEITKLNEELKSHKLESIK-EITNLKDAKQLLIQ 1170 Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187 + E++ + ++KA E+ + +Q LK+Q + ++E++L+ +F EKE KL Sbjct: 1171 QKLELQGKADSLKAAVEQEKRNQQILKDQVK----KEEEELKKEFIEKEAKLHSEIKEKE 1226 Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247 +++ E L + L +K ++ + + + E+E DL R E+A Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEW-QSSQRRVSELEKQTDDL-----RGEIAV 1280 Query: 248 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 307 EA + N+ + + +++ E IE L LE+ +R++ VQ Sbjct: 1281 LEA-------TVQNNQDERRALLERCLKGEGEIEKLQTKVLEL-----QRKLDNTTAAVQ 1328 Query: 308 RLQASLTKLRENSASQISQLE 328 L REN + QI + Sbjct: 1329 ELG------RENQSLQIKHTQ 1343 Score = 31.2 bits (69), Expect = 7.9 Identities = 28/148 (18%), Positives = 69/148 (46%), Gaps = 9/148 (6%) Query: 220 EETTAKADEIEMIMTDLERANQRAEVAQREAETLRE-QLSSANHSLQLASQIQKAPDVEQ 278 ++ T E++ + L+ +E ++E E + Q A + + +EQ Sbjct: 83 DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142 Query: 279 AIEVLTRSSLEVELAAK--EREIAQLVEDVQRLQASLTK---LRENSASQISQLEQQLSA 333 +E + ++ E++ AQL ++ +++ + LRE + ++++L ++L+ Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK 202 Query: 334 KNSTLKQLEEKLKGQADYEEV---KKEL 358 + + ++ L+ +L + E+V KKEL Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKEL 230 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.306 0.124 0.340 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 63,059,693 Number of Sequences: 37866 Number of extensions: 3620524 Number of successful extensions: 56480 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 750 Number of HSP's successfully gapped in prelim test: 2698 Number of HSP's that attempted gapping in prelim test: 27521 Number of HSP's gapped (non-prelim): 22882 length of query: 1505 length of database: 18,247,518 effective HSP length: 115 effective length of query: 1390 effective length of database: 13,892,928 effective search space: 19311169920 effective search space used: 19311169920 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.6 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.