Guide to the Human Genome
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Search of human proteins with 14589933

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]
         (1072 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]       2131   0.0  
gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens]       2105   0.0  
gi|14589935 protocadherin 7 isoform c precursor [Homo sapiens]       1957   0.0  
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]        968   0.0  
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]        967   0.0  
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]         694   0.0  
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]        694   0.0  
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]        607   e-173
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]        607   e-173
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]        607   e-173
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s...   605   e-173
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]        605   e-173
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]        605   e-173
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ...   605   e-173
gi|190194360 protocadherin 20 [Homo sapiens]                          405   e-112
gi|14270499 protocadherin gamma subfamily B, 4 isoform 2 precurs...   336   8e-92
gi|13470082 protocadherin gamma subfamily B, 4 isoform 1 precurs...   336   8e-92
gi|14270508 protocadherin gamma subfamily B, 7 isoform 2 precurs...   330   6e-90
gi|11128027 protocadherin gamma subfamily B, 7 isoform 1 precurs...   330   6e-90
gi|14277685 protocadherin gamma subfamily C, 5 isoform 2 precurs...   322   1e-87
gi|11128023 protocadherin gamma subfamily C, 5 isoform 1 precurs...   322   1e-87
gi|11128029 protocadherin gamma subfamily B, 6 isoform 1 precurs...   321   2e-87
gi|14270502 protocadherin gamma subfamily B, 6 isoform 2 precurs...   321   2e-87
gi|16933557 dachsous 1 precursor [Homo sapiens]                       320   6e-87
gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precurs...   317   3e-86
gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precurs...   317   3e-86
gi|9256586 protocadherin alpha 3 isoform 1 precursor [Homo sapiens]   315   1e-85
gi|14165410 protocadherin alpha 3 isoform 2 precursor [Homo sapi...   315   1e-85
gi|11036656 protocadherin beta 7 precursor [Homo sapiens]             312   9e-85
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]       312   1e-84

>gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]
          Length = 1072

 Score = 2131 bits (5522), Expect = 0.0
 Identities = 1072/1072 (100%), Positives = 1072/1072 (100%)

Query: 1    MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG 60
            MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG
Sbjct: 1    MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG 60

Query: 61   SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS 120
            SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS
Sbjct: 61   SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS 120

Query: 121  QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY 180
            QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY
Sbjct: 121  QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY 180

Query: 181  ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR 240
            ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR
Sbjct: 181  ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR 240

Query: 241  SSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITD 300
            SSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITD
Sbjct: 241  SSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITD 300

Query: 301  VNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL 360
            VNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL
Sbjct: 301  VNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL 360

Query: 361  DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI 420
            DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI
Sbjct: 361  DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI 420

Query: 421  GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ 480
            GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ
Sbjct: 421  GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ 480

Query: 481  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 540
            NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV
Sbjct: 481  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 540

Query: 541  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600
            EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE
Sbjct: 541  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600

Query: 601  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 660
            QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM
Sbjct: 601  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 660

Query: 661  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720
            VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP
Sbjct: 661  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720

Query: 721  PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN 780
            PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN
Sbjct: 721  PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN 780

Query: 781  YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN 840
            YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN
Sbjct: 781  YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN 840

Query: 841  ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM 900
            ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM
Sbjct: 841  ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM 900

Query: 901  ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN 960
            ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN
Sbjct: 901  ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN 960

Query: 961  GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA 1020
            GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA
Sbjct: 961  GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA 1020

Query: 1021 VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQVRCIPNIFKYPREG 1072
            VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQVRCIPNIFKYPREG
Sbjct: 1021 VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQVRCIPNIFKYPREG 1072


>gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens]
          Length = 1069

 Score = 2105 bits (5453), Expect = 0.0
 Identities = 1061/1065 (99%), Positives = 1062/1065 (99%)

Query: 1    MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG 60
            MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG
Sbjct: 1    MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG 60

Query: 61   SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS 120
            SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS
Sbjct: 61   SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS 120

Query: 121  QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY 180
            QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY
Sbjct: 121  QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY 180

Query: 181  ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR 240
            ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR
Sbjct: 181  ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR 240

Query: 241  SSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITD 300
            SSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITD
Sbjct: 241  SSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITD 300

Query: 301  VNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL 360
            VNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL
Sbjct: 301  VNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL 360

Query: 361  DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI 420
            DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI
Sbjct: 361  DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI 420

Query: 421  GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ 480
            GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ
Sbjct: 421  GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ 480

Query: 481  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 540
            NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV
Sbjct: 481  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 540

Query: 541  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600
            EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE
Sbjct: 541  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600

Query: 601  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 660
            QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM
Sbjct: 601  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 660

Query: 661  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720
            VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP
Sbjct: 661  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720

Query: 721  PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN 780
            PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN
Sbjct: 721  PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN 780

Query: 781  YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN 840
            YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN
Sbjct: 781  YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN 840

Query: 841  ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM 900
            ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM
Sbjct: 841  ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM 900

Query: 901  ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN 960
            ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN
Sbjct: 901  ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN 960

Query: 961  GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA 1020
            GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA
Sbjct: 961  GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA 1020

Query: 1021 VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQVRCIPNI 1065
            VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQ+R  P I
Sbjct: 1021 VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQMRLHPYI 1065


>gi|14589935 protocadherin 7 isoform c precursor [Homo sapiens]
          Length = 1200

 Score = 1957 bits (5071), Expect = 0.0
 Identities = 1000/1058 (94%), Positives = 1002/1058 (94%), Gaps = 47/1058 (4%)

Query: 1    MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG 60
            MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG
Sbjct: 1    MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG 60

Query: 61   SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS 120
            SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS
Sbjct: 61   SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS 120

Query: 121  QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY 180
            QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY
Sbjct: 121  QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY 180

Query: 181  ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR 240
            ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR
Sbjct: 181  ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR 240

Query: 241  SSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITD 300
            SSVFELQ                                V D  D  +  Q I+      
Sbjct: 241  SSVFELQ--------------------------------VADTPDGEKQPQLIV------ 262

Query: 301  VNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL 360
                     K VYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL
Sbjct: 263  ---------KGVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL 313

Query: 361  DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI 420
            DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI
Sbjct: 314  DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI 373

Query: 421  GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ 480
            GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ
Sbjct: 374  GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ 433

Query: 481  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 540
            NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV
Sbjct: 434  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 493

Query: 541  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600
            EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE
Sbjct: 494  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 553

Query: 601  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 660
            QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM
Sbjct: 554  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 613

Query: 661  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720
            VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP
Sbjct: 614  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 673

Query: 721  PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN 780
            PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN
Sbjct: 674  PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN 733

Query: 781  YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN 840
            YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN
Sbjct: 734  YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN 793

Query: 841  ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM 900
            ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM
Sbjct: 794  ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM 853

Query: 901  ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN 960
            ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN
Sbjct: 854  ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN 913

Query: 961  GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA 1020
            GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA
Sbjct: 914  GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA 973

Query: 1021 VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQ 1058
            VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQ
Sbjct: 974  VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQ 1011


>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
          Length = 1060

 Score =  968 bits (2503), Expect = 0.0
 Identities = 524/1048 (50%), Positives = 706/1048 (67%), Gaps = 66/1048 (6%)

Query: 19   LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKID 78
            LLL L+ S   A +++ Y++ EE P +  IG++A+D G     G + + LE G+ YL++D
Sbjct: 46   LLLLLAPSPGHATRVV-YKVPEEQPPNTLIGSLAADYGF-PDVGHL-YKLEVGAPYLRVD 102

Query: 79   NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVD-LFEGQVIVLDIN 137
              TG++ T+E  IDRE L +CQ     + C L+FEVS+    Q+    L EGQ+ V DIN
Sbjct: 103  GKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDIN 162

Query: 138  DNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRR 197
            DNTP F SPV+TL + EN  +G+L+ +P A+DRD G NG+  YEL   P           
Sbjct: 163  DNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGP----------- 211

Query: 198  AGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ 257
                                         +A E            +F LQVA+  + EKQ
Sbjct: 212  -----------------------------EAQE------------LFGLQVAEDQE-EKQ 229

Query: 258  PQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317
            PQLIV G LDRE+ DSY+LT++V+DGG PPR+S A+LRV + D NDN+P+FE+  YEA+L
Sbjct: 230  PQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAEL 289

Query: 318  AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREE 377
            +ENS  G  ++Q++A D D G N +IEY F  A E VRRLLRLD  +G ++V   +DRE+
Sbjct: 290  SENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRED 349

Query: 378  VNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVL 437
            ++ LRF+V+A+DRG  PK+ +A VV+ +KD NDN P+IEIR IG +  +DG+AN++EDV 
Sbjct: 350  LSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVA 409

Query: 438  VDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEA 497
             +T +ALVQVSDRD+GEN  VTC V GDVPFQL+ AS+T G  +KKKYFL T+TPLDYE 
Sbjct: 410  EETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET-GSDSKKKYFLQTTTPLDYEK 468

Query: 498  TREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATV 557
             +++ + IVAVDSG+P LSS NSL V+V D NDN P+F QSV EV FPENN PGE +A +
Sbjct: 469  VKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEI 528

Query: 558  LATDADSGKNAEIAYSLDS--SVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKG 615
             A+DADSG NAE+ YSL+   +  G+F I P++G+I V T LDREQ + YE KV A D+G
Sbjct: 529  TASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRG 588

Query: 616  IPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMS 675
             P LQG+ TV+V V D NDNDPKFM   + F V EN+   SPVGMVTV+D DKG NA++ 
Sbjct: 589  SPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQ 648

Query: 676  LYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDE 735
            L +E++N  F I+N TGTI S++SFDRE Q+TYTF++KAVDGG PPRSA   V++ V+DE
Sbjct: 649  LSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDE 708

Query: 736  NDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEID 795
            NDNAP +T P N S+ LL P + +   V+ V A D D G+NA+L YSI GGNP+ LF+I 
Sbjct: 709  NDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIG 768

Query: 796  PTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIAR 855
              SG ++L  ++ ++H+GLHRLVV+V+D G+P +  T LVH++VNE+++N T +++ +  
Sbjct: 769  SHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGH 828

Query: 856  SLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKN-KNGYEA 914
            SL  PL  DIAGDP YE SKQR +I+ GVVAG++ V L+I + V+ RYCR +  K+GY+A
Sbjct: 829  SLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQA 888

Query: 915  GKKDHEDFFTPQQHDKSKKPKKDK-KNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSD 973
            GKK+ +D + P+   K+ K  K K K  KS +P+       EA      +++ +++   D
Sbjct: 889  GKKETKDLYAPKPSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGD 948

Query: 974  SPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033
            SP +  +  +N  PGSPDL RHY+S+SPLP++QL PQSP+A KKHQ VQDLPPANTFVG 
Sbjct: 949  SPRI--HLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGT 1006

Query: 1034 GDNISIGSDHCSEYSCQTN-NKY-SKQV 1059
            GD  S GS+  S+YS +TN  KY SKQV
Sbjct: 1007 GDTTSTGSEQYSDYSYRTNPPKYPSKQV 1034


>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
          Length = 1237

 Score =  967 bits (2500), Expect = 0.0
 Identities = 523/1048 (49%), Positives = 706/1048 (67%), Gaps = 66/1048 (6%)

Query: 19   LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKID 78
            LLL L+ S   A +++ Y++ EE P +  IG++A+D G     G + + LE G+ YL++D
Sbjct: 46   LLLLLAPSPGHATRVV-YKVPEEQPPNTLIGSLAADYGF-PDVGHL-YKLEVGAPYLRVD 102

Query: 79   NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVD-LFEGQVIVLDIN 137
              TG++ T+E  IDRE L +CQ     + C L+FEVS+    Q+    L EGQ+ V DIN
Sbjct: 103  GKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDIN 162

Query: 138  DNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRR 197
            DNTP F SPV+TL + EN  +G+L+ +P A+DRD G NG+  YEL   P           
Sbjct: 163  DNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGP----------- 211

Query: 198  AGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ 257
                                         +A E            +F LQVA+  + EKQ
Sbjct: 212  -----------------------------EAQE------------LFGLQVAEDQE-EKQ 229

Query: 258  PQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317
            PQLIV G LDRE+ DSY+LT++V+DGG PPR+S A+LRV + D NDN+P+FE+  YEA+L
Sbjct: 230  PQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAEL 289

Query: 318  AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREE 377
            +ENS  G  ++Q++A D D G N +IEY F  A E VRRLLRLD  +G ++V   +DRE+
Sbjct: 290  SENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDRED 349

Query: 378  VNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVL 437
            ++ LRF+V+A+DRG  PK+ +A VV+ +KD NDN P+IEIR IG +  +DG+AN++EDV 
Sbjct: 350  LSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVA 409

Query: 438  VDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEA 497
             +T +ALVQVSDRD+GEN  VTC V GDVPFQL+ AS+T G  +KKKYFL T+TPLDYE 
Sbjct: 410  EETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET-GSDSKKKYFLQTTTPLDYEK 468

Query: 498  TREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATV 557
             +++ + IVAVDSG+P LSS NSL V+V D NDN P+F QSV EV FPENN PGE +A +
Sbjct: 469  VKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEI 528

Query: 558  LATDADSGKNAEIAYSLDS--SVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKG 615
             A+DADSG NAE+ YSL+   +  G+F I P++G+I V T LDREQ + YE KV A D+G
Sbjct: 529  TASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRG 588

Query: 616  IPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMS 675
             P LQG+ TV+V V D NDNDPKFM   + F V EN+   SPVGMVTV+D DKG NA++ 
Sbjct: 589  SPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQ 648

Query: 676  LYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDE 735
            L +E++N  F I+N TGTI S++SFDRE Q+TYTF++KAVDGG PPRSA   V++ V+DE
Sbjct: 649  LSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDE 708

Query: 736  NDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEID 795
            NDNAP +T P N S+ LL P + +   V+ V A D D G+NA+L YSI GGNP+ LF+I 
Sbjct: 709  NDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIG 768

Query: 796  PTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIAR 855
              SG ++L  ++ ++H+GLHRLVV+V+D G+P +  T LVH++VNE+++N T +++ +  
Sbjct: 769  SHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGH 828

Query: 856  SLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKN-KNGYEA 914
            SL  PL  DIAGDP YE SKQR +I+ GVVAG++ V L+I + V+ RYCR +  K+GY+A
Sbjct: 829  SLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQA 888

Query: 915  GKKDHEDFFTPQQHDKSKKPKKDK-KNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSD 973
            GKK+ +D + P+   K+ K  K K K  KS +P+       EA      +++ +++   D
Sbjct: 889  GKKETKDLYAPKPSGKASKGNKSKGKKSKSPKPVKPVEDEDEAGLQKSLKFNLMSDAPGD 948

Query: 974  SPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033
            SP +  +  +N  PGSPDL RHY+S+SPLP++QL PQSP+A KKHQ VQDLPPANTFVG 
Sbjct: 949  SPRI--HLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQDLPPANTFVGT 1006

Query: 1034 GDNISIGSDHCSEYSCQTN-NKY-SKQV 1059
            GD  S GS+  S+YS +TN  KY SKQ+
Sbjct: 1007 GDTTSTGSEQYSDYSYRTNPPKYPSKQL 1034


>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
          Length = 1203

 Score =  694 bits (1792), Expect = 0.0
 Identities = 425/1071 (39%), Positives = 603/1071 (56%), Gaps = 98/1071 (9%)

Query: 11   RGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGI-----VTG-SGEV 64
            R + L   L+  L L  A A++L+ Y + EE P +V IGN+  DL I      TG S  +
Sbjct: 4    RDFYLLAALIACLRLDSAIAQELI-YTIREELPENVPIGNIPKDLNISHINAATGTSASL 62

Query: 65   TFSLES---GSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQ 121
             + L S    +  +K+ + TGE+ T+  RIDREKL       +ENECF + EV ++    
Sbjct: 63   VYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVIL--PN 120

Query: 122  SWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYE 181
             +  L + ++IV D NDN P FPSPV+ +++ EN  + + + +P+ATD            
Sbjct: 121  DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATD------------ 168

Query: 182  LLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRS 241
                                     P  G NG          +  +   G          
Sbjct: 169  -------------------------PDTGFNGV---------QHYELLNG---------Q 185

Query: 242  SVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDV 301
            SVF L + +TP+GEK PQLIV+  LDREQ+D+Y + ++V DGG P +SS AIL+V ++DV
Sbjct: 186  SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245

Query: 302  NDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGA-ATESVRRLLRL 360
            NDN P F++   E  + EN+  GT ++QL A D D+G N +I Y+FGA    + +RL  L
Sbjct: 246  NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305

Query: 361  DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI 420
            + T+G ++V   +DREE    + TV+A D    P   +ATV +N+ D NDN P+I++R I
Sbjct: 306  NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPA--RATVTINVTDVNDNPPNIDLRYI 363

Query: 421  GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ 480
              I   +G   ++E   V+T IAL+ VSD+D   NG V C +  +VPF LK   D +   
Sbjct: 364  --ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ--- 418

Query: 481  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 540
                Y L TS+ LDYE T+EF+  IVA DSG PSL+    + VK+ D NDNPP+F Q V+
Sbjct: 419  ----YLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVI 474

Query: 541  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600
            E+   ENN  G  + T+ ATD DSGKNA+I Y L  +    F +D  +G +  + V DRE
Sbjct: 475  ELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDRE 533

Query: 601  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 660
            + +R+ F V A+D G P LQ    VIV V D+NDN PKF  + F F+V ENL   S VG+
Sbjct: 534  EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593

Query: 661  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720
            +TV DAD G N  ++L I  +N+ F ++  +G I S +SFDRE Q++YTF VKA DGG P
Sbjct: 594  ITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653

Query: 721  PRSATATVSLFVMDENDNAPTV-TLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADL 779
            PRS+TA V++ VMD NDN+P V + P N S+ L+P S+   +VVA V A D D G+NA+L
Sbjct: 654  PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713

Query: 780  NYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVF 838
             Y+IV GN   LF IDP +G ++L  K      GLHRLVV ++D G P S  T  LV ++
Sbjct: 714  KYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLY 773

Query: 839  VNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIV 898
            VN++  NA+ I   I R++  PL ++I        ++  L+I+I ++AG M VI++I + 
Sbjct: 774  VNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVT 833

Query: 899  VMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASK 958
            V+ R CR  ++       K   ++ +P Q +K  K KK KK K  K  L  + VT+E SK
Sbjct: 834  VLVR-CRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLL-NFVTIEESK 891

Query: 959  PNGQRYDSVNEKLS-----DSPSMGRY-----RSVNGGPGSPDLARHYKSSSPLPTVQLH 1008
            P+   ++ +N  +S     +  S+GR+           P SPDLA+HYKS+SP P   L 
Sbjct: 892  PDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLK 951

Query: 1009 PQSPTAGKKHQAVQDLPPANTFVGAGDNI----SIGSDHCSEYSCQTNNKY 1055
            P +P + KKH  +Q+LP  NTFVG  D +    S  SDH S   C +   +
Sbjct: 952  PDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGF 1002


>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
          Length = 1237

 Score =  694 bits (1792), Expect = 0.0
 Identities = 425/1071 (39%), Positives = 603/1071 (56%), Gaps = 98/1071 (9%)

Query: 11   RGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGI-----VTG-SGEV 64
            R + L   L+  L L  A A++L+ Y + EE P +V IGN+  DL I      TG S  +
Sbjct: 4    RDFYLLAALIACLRLDSAIAQELI-YTIREELPENVPIGNIPKDLNISHINAATGTSASL 62

Query: 65   TFSLES---GSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQ 121
             + L S    +  +K+ + TGE+ T+  RIDREKL       +ENECF + EV ++    
Sbjct: 63   VYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVIL--PN 120

Query: 122  SWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYE 181
             +  L + ++IV D NDN P FPSPV+ +++ EN  + + + +P+ATD            
Sbjct: 121  DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATD------------ 168

Query: 182  LLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRS 241
                                     P  G NG          +  +   G          
Sbjct: 169  -------------------------PDTGFNGV---------QHYELLNG---------Q 185

Query: 242  SVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDV 301
            SVF L + +TP+GEK PQLIV+  LDREQ+D+Y + ++V DGG P +SS AIL+V ++DV
Sbjct: 186  SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245

Query: 302  NDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGA-ATESVRRLLRL 360
            NDN P F++   E  + EN+  GT ++QL A D D+G N +I Y+FGA    + +RL  L
Sbjct: 246  NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305

Query: 361  DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI 420
            + T+G ++V   +DREE    + TV+A D    P   +ATV +N+ D NDN P+I++R I
Sbjct: 306  NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPA--RATVTINVTDVNDNPPNIDLRYI 363

Query: 421  GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ 480
              I   +G   ++E   V+T IAL+ VSD+D   NG V C +  +VPF LK   D +   
Sbjct: 364  --ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ--- 418

Query: 481  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 540
                Y L TS+ LDYE T+EF+  IVA DSG PSL+    + VK+ D NDNPP+F Q V+
Sbjct: 419  ----YLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVI 474

Query: 541  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600
            E+   ENN  G  + T+ ATD DSGKNA+I Y L  +    F +D  +G +  + V DRE
Sbjct: 475  ELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDRE 533

Query: 601  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 660
            + +R+ F V A+D G P LQ    VIV V D+NDN PKF  + F F+V ENL   S VG+
Sbjct: 534  EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593

Query: 661  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720
            +TV DAD G N  ++L I  +N+ F ++  +G I S +SFDRE Q++YTF VKA DGG P
Sbjct: 594  ITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653

Query: 721  PRSATATVSLFVMDENDNAPTV-TLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADL 779
            PRS+TA V++ VMD NDN+P V + P N S+ L+P S+   +VVA V A D D G+NA+L
Sbjct: 654  PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713

Query: 780  NYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVF 838
             Y+IV GN   LF IDP +G ++L  K      GLHRLVV ++D G P S  T  LV ++
Sbjct: 714  KYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLY 773

Query: 839  VNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIV 898
            VN++  NA+ I   I R++  PL ++I        ++  L+I+I ++AG M VI++I + 
Sbjct: 774  VNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVT 833

Query: 899  VMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASK 958
            V+ R CR  ++       K   ++ +P Q +K  K KK KK K  K  L  + VT+E SK
Sbjct: 834  VLVR-CRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLL-NFVTIEESK 891

Query: 959  PNGQRYDSVNEKLS-----DSPSMGRY-----RSVNGGPGSPDLARHYKSSSPLPTVQLH 1008
            P+   ++ +N  +S     +  S+GR+           P SPDLA+HYKS+SP P   L 
Sbjct: 892  PDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLK 951

Query: 1009 PQSPTAGKKHQAVQDLPPANTFVGAGDNI----SIGSDHCSEYSCQTNNKY 1055
            P +P + KKH  +Q+LP  NTFVG  D +    S  SDH S   C +   +
Sbjct: 952  PDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGF 1002


>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
          Length = 1340

 Score =  607 bits (1564), Expect = e-173
 Identities = 383/1033 (37%), Positives = 571/1033 (55%), Gaps = 95/1033 (9%)

Query: 36   YRLAEEGPADVRIGNVASDLGI-------VTGSGEVTFSLESGS-EYLKIDNLTGELSTS 87
            Y + EE P +V IGN+  DL +       +T + +     ++G    ++I+  TGE+ T+
Sbjct: 60   YTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTT 119

Query: 88   ERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPV 147
              RIDREKL  C  I  +  CF + EV+++ P + +  L + + ++ DINDN P FP+ V
Sbjct: 120  GARIDREKL--CAGIPRDEHCFYEVEVAIL-PDEIF-RLVKIRFLIEDINDNAPLFPATV 175

Query: 148  LTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYP 207
            + +++ EN  + + Y LP A D D G NG++ YEL+          +S+     D    P
Sbjct: 176  INISIPENSAINSKYTLPAAVDPDVGINGVQNYELI----------KSQNIFGLDVIETP 225

Query: 208  GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALD 267
             G                                 + +L V    D E++   ++K    
Sbjct: 226  EG-------------------------------DKMPQLIVQKELDREEKDTYVMK---- 250

Query: 268  REQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPI 327
                      ++V DGG P RSS AIL+V +TD NDN P F+++  E  + EN+  GT +
Sbjct: 251  ----------VKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSV 300

Query: 328  LQLRAADLDVGVNGQIEYVFGAATESV-RRLLRLDETSGWLSVLHRIDREEVNQLRFTVM 386
             QL A D D+G N +I + F     ++ RRL  L+ T+G +++   +DREE    +  V+
Sbjct: 301  TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVL 360

Query: 387  ARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQ 446
            A D G  P   +A V++N+ D NDNVPSI+IR I   P+ D V  ++E++ ++T IAL+ 
Sbjct: 361  ASDGGLMPA--RAMVLVNVTDVNDNVPSIDIRYIVN-PVNDTVV-LSENIPLNTKIALIT 416

Query: 447  VSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIV 506
            V+D+D   NG VTC    ++PF+L+P    +       + L  +  LDYE+T+E+ + ++
Sbjct: 417  VTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ-------FLLENAAYLDYESTKEYAIKLL 469

Query: 507  AVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGK 566
            A D+G P L+ +  L +KV D NDN P+F QS V V  PENN PG ++  V ATDADSG 
Sbjct: 470  AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGP 529

Query: 567  NAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVI 626
            NAEI Y L       F++D  +G + V   LDRE+ D+Y F + AKD G+P L  + TV 
Sbjct: 530  NAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVF 589

Query: 627  VQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFS 686
            V + D+NDN P F  + + FYV ENL  +  VG++TV D D G N+ ++L I + N+ F+
Sbjct: 590  VSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFT 649

Query: 687  IENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-VTLP 745
            I++ TG I   +SFDRE Q +YTF VKA DGG   RS++A V++ V+D NDN P  +  P
Sbjct: 650  IDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPP 709

Query: 746  KNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVG 805
             N SY L+ PS+N  TVV  V+A D+D G+NA++ YSIVGGN   LF ID  +G ++L+ 
Sbjct: 710  YNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLME 769

Query: 806  KLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQD 864
            K      GLHR++V+ ND GQP S  +  +V++FVNESV+NAT I+  + +S+  P+T +
Sbjct: 770  KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPN 829

Query: 865  IAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFT 924
                     +   + I++  VAG +TV+++I I  + R CR             + ++ T
Sbjct: 830  TEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVR-CRQAPHLKAAQKNMQNSEWAT 888

Query: 925  PQQHDKSKKPKKDKKNKKSKQP--LYSSIVTVEASKPNGQRYDSVNEKLS-----DSPSM 977
            P   ++     K KK KK   P  L  ++VT+E +K +    D     L      +  +M
Sbjct: 889  PNPENRQMIMMKKKKKKKKHSPKNLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTM 948

Query: 978  GRYRSVNG----GPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033
            G+Y  V       P SPDLARHYKS+SP P  Q+ P++P    KH  +Q+LP  NTFV A
Sbjct: 949  GKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETP-LNLKHHIIQELPLDNTFV-A 1006

Query: 1034 GDNISIGSDHCSE 1046
             D+IS  S   S+
Sbjct: 1007 CDSISNCSSSSSD 1019


>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
          Length = 1048

 Score =  607 bits (1564), Expect = e-173
 Identities = 383/1033 (37%), Positives = 571/1033 (55%), Gaps = 95/1033 (9%)

Query: 36   YRLAEEGPADVRIGNVASDLGI-------VTGSGEVTFSLESGS-EYLKIDNLTGELSTS 87
            Y + EE P +V IGN+  DL +       +T + +     ++G    ++I+  TGE+ T+
Sbjct: 60   YTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTT 119

Query: 88   ERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPV 147
              RIDREKL  C  I  +  CF + EV+++ P + +  L + + ++ DINDN P FP+ V
Sbjct: 120  GARIDREKL--CAGIPRDEHCFYEVEVAIL-PDEIF-RLVKIRFLIEDINDNAPLFPATV 175

Query: 148  LTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYP 207
            + +++ EN  + + Y LP A D D G NG++ YEL+          +S+     D    P
Sbjct: 176  INISIPENSAINSKYTLPAAVDPDVGINGVQNYELI----------KSQNIFGLDVIETP 225

Query: 208  GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALD 267
             G                                 + +L V    D E++   ++K    
Sbjct: 226  EG-------------------------------DKMPQLIVQKELDREEKDTYVMK---- 250

Query: 268  REQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPI 327
                      ++V DGG P RSS AIL+V +TD NDN P F+++  E  + EN+  GT +
Sbjct: 251  ----------VKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSV 300

Query: 328  LQLRAADLDVGVNGQIEYVFGAATESV-RRLLRLDETSGWLSVLHRIDREEVNQLRFTVM 386
             QL A D D+G N +I + F     ++ RRL  L+ T+G +++   +DREE    +  V+
Sbjct: 301  TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVL 360

Query: 387  ARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQ 446
            A D G  P   +A V++N+ D NDNVPSI+IR I   P+ D V  ++E++ ++T IAL+ 
Sbjct: 361  ASDGGLMPA--RAMVLVNVTDVNDNVPSIDIRYIVN-PVNDTVV-LSENIPLNTKIALIT 416

Query: 447  VSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIV 506
            V+D+D   NG VTC    ++PF+L+P    +       + L  +  LDYE+T+E+ + ++
Sbjct: 417  VTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ-------FLLENAAYLDYESTKEYAIKLL 469

Query: 507  AVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGK 566
            A D+G P L+ +  L +KV D NDN P+F QS V V  PENN PG ++  V ATDADSG 
Sbjct: 470  AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGP 529

Query: 567  NAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVI 626
            NAEI Y L       F++D  +G + V   LDRE+ D+Y F + AKD G+P L  + TV 
Sbjct: 530  NAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVF 589

Query: 627  VQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFS 686
            V + D+NDN P F  + + FYV ENL  +  VG++TV D D G N+ ++L I + N+ F+
Sbjct: 590  VSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFT 649

Query: 687  IENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-VTLP 745
            I++ TG I   +SFDRE Q +YTF VKA DGG   RS++A V++ V+D NDN P  +  P
Sbjct: 650  IDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPP 709

Query: 746  KNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVG 805
             N SY L+ PS+N  TVV  V+A D+D G+NA++ YSIVGGN   LF ID  +G ++L+ 
Sbjct: 710  YNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLME 769

Query: 806  KLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQD 864
            K      GLHR++V+ ND GQP S  +  +V++FVNESV+NAT I+  + +S+  P+T +
Sbjct: 770  KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPN 829

Query: 865  IAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFT 924
                     +   + I++  VAG +TV+++I I  + R CR             + ++ T
Sbjct: 830  TEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVR-CRQAPHLKAAQKNMQNSEWAT 888

Query: 925  PQQHDKSKKPKKDKKNKKSKQP--LYSSIVTVEASKPNGQRYDSVNEKLS-----DSPSM 977
            P   ++     K KK KK   P  L  ++VT+E +K +    D     L      +  +M
Sbjct: 889  PNPENRQMIMMKKKKKKKKHSPKNLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTM 948

Query: 978  GRYRSVNG----GPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033
            G+Y  V       P SPDLARHYKS+SP P  Q+ P++P    KH  +Q+LP  NTFV A
Sbjct: 949  GKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETP-LNLKHHIIQELPLDNTFV-A 1006

Query: 1034 GDNISIGSDHCSE 1046
             D+IS  S   S+
Sbjct: 1007 CDSISNCSSSSSD 1019


>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
          Length = 1037

 Score =  607 bits (1564), Expect = e-173
 Identities = 383/1033 (37%), Positives = 571/1033 (55%), Gaps = 95/1033 (9%)

Query: 36   YRLAEEGPADVRIGNVASDLGI-------VTGSGEVTFSLESGS-EYLKIDNLTGELSTS 87
            Y + EE P +V IGN+  DL +       +T + +     ++G    ++I+  TGE+ T+
Sbjct: 49   YTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTT 108

Query: 88   ERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPV 147
              RIDREKL  C  I  +  CF + EV+++ P + +  L + + ++ DINDN P FP+ V
Sbjct: 109  GARIDREKL--CAGIPRDEHCFYEVEVAIL-PDEIF-RLVKIRFLIEDINDNAPLFPATV 164

Query: 148  LTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYP 207
            + +++ EN  + + Y LP A D D G NG++ YEL+          +S+     D    P
Sbjct: 165  INISIPENSAINSKYTLPAAVDPDVGINGVQNYELI----------KSQNIFGLDVIETP 214

Query: 208  GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALD 267
             G                                 + +L V    D E++   ++K    
Sbjct: 215  EG-------------------------------DKMPQLIVQKELDREEKDTYVMK---- 239

Query: 268  REQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPI 327
                      ++V DGG P RSS AIL+V +TD NDN P F+++  E  + EN+  GT +
Sbjct: 240  ----------VKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSV 289

Query: 328  LQLRAADLDVGVNGQIEYVFGAATESV-RRLLRLDETSGWLSVLHRIDREEVNQLRFTVM 386
             QL A D D+G N +I + F     ++ RRL  L+ T+G +++   +DREE    +  V+
Sbjct: 290  TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVL 349

Query: 387  ARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQ 446
            A D G  P   +A V++N+ D NDNVPSI+IR I   P+ D V  ++E++ ++T IAL+ 
Sbjct: 350  ASDGGLMPA--RAMVLVNVTDVNDNVPSIDIRYIVN-PVNDTVV-LSENIPLNTKIALIT 405

Query: 447  VSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIV 506
            V+D+D   NG VTC    ++PF+L+P    +       + L  +  LDYE+T+E+ + ++
Sbjct: 406  VTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ-------FLLENAAYLDYESTKEYAIKLL 458

Query: 507  AVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGK 566
            A D+G P L+ +  L +KV D NDN P+F QS V V  PENN PG ++  V ATDADSG 
Sbjct: 459  AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGP 518

Query: 567  NAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVI 626
            NAEI Y L       F++D  +G + V   LDRE+ D+Y F + AKD G+P L  + TV 
Sbjct: 519  NAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVF 578

Query: 627  VQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFS 686
            V + D+NDN P F  + + FYV ENL  +  VG++TV D D G N+ ++L I + N+ F+
Sbjct: 579  VSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFT 638

Query: 687  IENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-VTLP 745
            I++ TG I   +SFDRE Q +YTF VKA DGG   RS++A V++ V+D NDN P  +  P
Sbjct: 639  IDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPP 698

Query: 746  KNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVG 805
             N SY L+ PS+N  TVV  V+A D+D G+NA++ YSIVGGN   LF ID  +G ++L+ 
Sbjct: 699  YNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLME 758

Query: 806  KLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQD 864
            K      GLHR++V+ ND GQP S  +  +V++FVNESV+NAT I+  + +S+  P+T +
Sbjct: 759  KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPN 818

Query: 865  IAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFT 924
                     +   + I++  VAG +TV+++I I  + R CR             + ++ T
Sbjct: 819  TEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVR-CRQAPHLKAAQKNMQNSEWAT 877

Query: 925  PQQHDKSKKPKKDKKNKKSKQP--LYSSIVTVEASKPNGQRYDSVNEKLS-----DSPSM 977
            P   ++     K KK KK   P  L  ++VT+E +K +    D     L      +  +M
Sbjct: 878  PNPENRQMIMMKKKKKKKKHSPKNLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTM 937

Query: 978  GRYRSVNG----GPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033
            G+Y  V       P SPDLARHYKS+SP P  Q+ P++P    KH  +Q+LP  NTFV A
Sbjct: 938  GKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETP-LNLKHHIIQELPLDNTFV-A 995

Query: 1034 GDNISIGSDHCSE 1046
             D+IS  S   S+
Sbjct: 996  CDSISNCSSSSSD 1008


>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
            sapiens]
          Length = 1021

 Score =  605 bits (1560), Expect = e-173
 Identities = 382/1033 (36%), Positives = 570/1033 (55%), Gaps = 95/1033 (9%)

Query: 36   YRLAEEGPADVRIGNVASDLGI-------VTGSGEVTFSLESGS-EYLKIDNLTGELSTS 87
            Y + EE P +V IG++  DL +       +T + +     ++G    ++I+  TGE+ T+
Sbjct: 28   YTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTT 87

Query: 88   ERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPV 147
              RIDREKL  C  I  +  CF + EV+++ P + +  L + + ++ DINDN P FP+ V
Sbjct: 88   GARIDREKL--CAGIPRDEHCFYEVEVAIL-PDEIF-RLVKIRFLIEDINDNAPLFPATV 143

Query: 148  LTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYP 207
            + +++ EN  + + Y LP A D D G NG++ YEL+          +S+     D    P
Sbjct: 144  INISIPENSAINSKYTLPAAVDPDVGINGVQNYELI----------KSQNIFGLDVIETP 193

Query: 208  GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALD 267
             G                                 + +L V    D E++   ++K    
Sbjct: 194  EG-------------------------------DKMPQLIVQKELDREEKDTYVMK---- 218

Query: 268  REQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPI 327
                      ++V DGG P RSS AIL+V +TD NDN P F+++  E  + EN+  GT +
Sbjct: 219  ----------VKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSV 268

Query: 328  LQLRAADLDVGVNGQIEYVFGAATESV-RRLLRLDETSGWLSVLHRIDREEVNQLRFTVM 386
             QL A D D+G N +I + F     ++ RRL  L+ T+G +++   +DREE    +  V+
Sbjct: 269  TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVL 328

Query: 387  ARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQ 446
            A D G  P   +A V++N+ D NDNVPSI+IR I   P+ D V  ++E++ ++T IAL+ 
Sbjct: 329  ASDGGLMPA--RAMVLVNVTDVNDNVPSIDIRYIVN-PVNDTVV-LSENIPLNTKIALIT 384

Query: 447  VSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIV 506
            V+D+D   NG VTC    ++PF+L+P    +       + L T+  LDYE+T+E+ + ++
Sbjct: 385  VTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ-------FLLETAAYLDYESTKEYAIKLL 437

Query: 507  AVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGK 566
            A D+G P L+ +  L +KV D NDN P+F QS V V  PENN PG ++  V A DADSG 
Sbjct: 438  AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGP 497

Query: 567  NAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVI 626
            NA+I Y L       F++D  +G + V   LDRE+ D+Y F + AKD G+P L  + TV 
Sbjct: 498  NAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVF 557

Query: 627  VQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFS 686
            V + D+NDN P F  + + FYV ENL  +  VG++TV D D G N+ ++L I + N+ F+
Sbjct: 558  VSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFT 617

Query: 687  IENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-VTLP 745
            I++ TG I   +SFDRE Q +YTF VKA DGG   RS++A V++ V+D NDN P  +  P
Sbjct: 618  IDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPP 677

Query: 746  KNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVG 805
             N SY L+ PS+N  TVV  V+A D+D G+NA++ YSIVGGN   LF ID  +G ++L+ 
Sbjct: 678  SNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLME 737

Query: 806  KLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQD 864
            K      GLHR++V+ ND GQP S  +  +V++FVNESV+NAT I+  + +S   P+T +
Sbjct: 738  KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPN 797

Query: 865  IAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFT 924
                     +   + I++  VAG +TV+++I I  + R CR           K + ++ T
Sbjct: 798  TEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVR-CRQAPHLKAAQKNKQNSEWAT 856

Query: 925  PQQHDKSKKPKKDKKNKKSKQP--LYSSIVTVEASKPNGQRYDSVNEKLS-----DSPSM 977
            P   ++     K KK KK   P  L  + VT+E +K +    D     L      +  +M
Sbjct: 857  PNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTM 916

Query: 978  GRYRSVNG----GPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033
            G+Y  V       P SPDLARHYKS+SP P  Q+ P++P    KH  +Q+LP  NTFV A
Sbjct: 917  GKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFV-A 974

Query: 1034 GDNISIGSDHCSE 1046
             D+IS  S   S+
Sbjct: 975  CDSISKCSSSSSD 987


>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
          Length = 1337

 Score =  605 bits (1560), Expect = e-173
 Identities = 382/1033 (36%), Positives = 570/1033 (55%), Gaps = 95/1033 (9%)

Query: 36   YRLAEEGPADVRIGNVASDLGI-------VTGSGEVTFSLESGS-EYLKIDNLTGELSTS 87
            Y + EE P +V IG++  DL +       +T + +     ++G    ++I+  TGE+ T+
Sbjct: 28   YTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTT 87

Query: 88   ERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPV 147
              RIDREKL  C  I  +  CF + EV+++ P + +  L + + ++ DINDN P FP+ V
Sbjct: 88   GARIDREKL--CAGIPRDEHCFYEVEVAIL-PDEIF-RLVKIRFLIEDINDNAPLFPATV 143

Query: 148  LTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYP 207
            + +++ EN  + + Y LP A D D G NG++ YEL+          +S+     D    P
Sbjct: 144  INISIPENSAINSKYTLPAAVDPDVGINGVQNYELI----------KSQNIFGLDVIETP 193

Query: 208  GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALD 267
             G                                 + +L V    D E++   ++K    
Sbjct: 194  EG-------------------------------DKMPQLIVQKELDREEKDTYVMK---- 218

Query: 268  REQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPI 327
                      ++V DGG P RSS AIL+V +TD NDN P F+++  E  + EN+  GT +
Sbjct: 219  ----------VKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSV 268

Query: 328  LQLRAADLDVGVNGQIEYVFGAATESV-RRLLRLDETSGWLSVLHRIDREEVNQLRFTVM 386
             QL A D D+G N +I + F     ++ RRL  L+ T+G +++   +DREE    +  V+
Sbjct: 269  TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVL 328

Query: 387  ARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQ 446
            A D G  P   +A V++N+ D NDNVPSI+IR I   P+ D V  ++E++ ++T IAL+ 
Sbjct: 329  ASDGGLMPA--RAMVLVNVTDVNDNVPSIDIRYIVN-PVNDTVV-LSENIPLNTKIALIT 384

Query: 447  VSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIV 506
            V+D+D   NG VTC    ++PF+L+P    +       + L T+  LDYE+T+E+ + ++
Sbjct: 385  VTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ-------FLLETAAYLDYESTKEYAIKLL 437

Query: 507  AVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGK 566
            A D+G P L+ +  L +KV D NDN P+F QS V V  PENN PG ++  V A DADSG 
Sbjct: 438  AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGP 497

Query: 567  NAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVI 626
            NA+I Y L       F++D  +G + V   LDRE+ D+Y F + AKD G+P L  + TV 
Sbjct: 498  NAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVF 557

Query: 627  VQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFS 686
            V + D+NDN P F  + + FYV ENL  +  VG++TV D D G N+ ++L I + N+ F+
Sbjct: 558  VSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFT 617

Query: 687  IENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-VTLP 745
            I++ TG I   +SFDRE Q +YTF VKA DGG   RS++A V++ V+D NDN P  +  P
Sbjct: 618  IDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPP 677

Query: 746  KNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVG 805
             N SY L+ PS+N  TVV  V+A D+D G+NA++ YSIVGGN   LF ID  +G ++L+ 
Sbjct: 678  SNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLME 737

Query: 806  KLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQD 864
            K      GLHR++V+ ND GQP S  +  +V++FVNESV+NAT I+  + +S   P+T +
Sbjct: 738  KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPN 797

Query: 865  IAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFT 924
                     +   + I++  VAG +TV+++I I  + R CR           K + ++ T
Sbjct: 798  TEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVR-CRQAPHLKAAQKNKQNSEWAT 856

Query: 925  PQQHDKSKKPKKDKKNKKSKQP--LYSSIVTVEASKPNGQRYDSVNEKLS-----DSPSM 977
            P   ++     K KK KK   P  L  + VT+E +K +    D     L      +  +M
Sbjct: 857  PNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTM 916

Query: 978  GRYRSVNG----GPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033
            G+Y  V       P SPDLARHYKS+SP P  Q+ P++P    KH  +Q+LP  NTFV A
Sbjct: 917  GKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFV-A 974

Query: 1034 GDNISIGSDHCSE 1046
             D+IS  S   S+
Sbjct: 975  CDSISKCSSSSSD 987


>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
          Length = 1347

 Score =  605 bits (1560), Expect = e-173
 Identities = 382/1033 (36%), Positives = 570/1033 (55%), Gaps = 95/1033 (9%)

Query: 36   YRLAEEGPADVRIGNVASDLGI-------VTGSGEVTFSLESGS-EYLKIDNLTGELSTS 87
            Y + EE P +V IG++  DL +       +T + +     ++G    ++I+  TGE+ T+
Sbjct: 28   YTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTT 87

Query: 88   ERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPV 147
              RIDREKL  C  I  +  CF + EV+++ P + +  L + + ++ DINDN P FP+ V
Sbjct: 88   GARIDREKL--CAGIPRDEHCFYEVEVAIL-PDEIF-RLVKIRFLIEDINDNAPLFPATV 143

Query: 148  LTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYP 207
            + +++ EN  + + Y LP A D D G NG++ YEL+          +S+     D    P
Sbjct: 144  INISIPENSAINSKYTLPAAVDPDVGINGVQNYELI----------KSQNIFGLDVIETP 193

Query: 208  GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALD 267
             G                                 + +L V    D E++   ++K    
Sbjct: 194  EG-------------------------------DKMPQLIVQKELDREEKDTYVMK---- 218

Query: 268  REQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPI 327
                      ++V DGG P RSS AIL+V +TD NDN P F+++  E  + EN+  GT +
Sbjct: 219  ----------VKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSV 268

Query: 328  LQLRAADLDVGVNGQIEYVFGAATESV-RRLLRLDETSGWLSVLHRIDREEVNQLRFTVM 386
             QL A D D+G N +I + F     ++ RRL  L+ T+G +++   +DREE    +  V+
Sbjct: 269  TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVL 328

Query: 387  ARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQ 446
            A D G  P   +A V++N+ D NDNVPSI+IR I   P+ D V  ++E++ ++T IAL+ 
Sbjct: 329  ASDGGLMPA--RAMVLVNVTDVNDNVPSIDIRYIVN-PVNDTVV-LSENIPLNTKIALIT 384

Query: 447  VSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIV 506
            V+D+D   NG VTC    ++PF+L+P    +       + L T+  LDYE+T+E+ + ++
Sbjct: 385  VTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ-------FLLETAAYLDYESTKEYAIKLL 437

Query: 507  AVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGK 566
            A D+G P L+ +  L +KV D NDN P+F QS V V  PENN PG ++  V A DADSG 
Sbjct: 438  AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGP 497

Query: 567  NAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVI 626
            NA+I Y L       F++D  +G + V   LDRE+ D+Y F + AKD G+P L  + TV 
Sbjct: 498  NAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVF 557

Query: 627  VQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFS 686
            V + D+NDN P F  + + FYV ENL  +  VG++TV D D G N+ ++L I + N+ F+
Sbjct: 558  VSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFT 617

Query: 687  IENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-VTLP 745
            I++ TG I   +SFDRE Q +YTF VKA DGG   RS++A V++ V+D NDN P  +  P
Sbjct: 618  IDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPP 677

Query: 746  KNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVG 805
             N SY L+ PS+N  TVV  V+A D+D G+NA++ YSIVGGN   LF ID  +G ++L+ 
Sbjct: 678  SNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLME 737

Query: 806  KLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQD 864
            K      GLHR++V+ ND GQP S  +  +V++FVNESV+NAT I+  + +S   P+T +
Sbjct: 738  KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPN 797

Query: 865  IAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFT 924
                     +   + I++  VAG +TV+++I I  + R CR           K + ++ T
Sbjct: 798  TEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVR-CRQAPHLKAAQKNKQNSEWAT 856

Query: 925  PQQHDKSKKPKKDKKNKKSKQP--LYSSIVTVEASKPNGQRYDSVNEKLS-----DSPSM 977
            P   ++     K KK KK   P  L  + VT+E +K +    D     L      +  +M
Sbjct: 857  PNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTM 916

Query: 978  GRYRSVNG----GPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033
            G+Y  V       P SPDLARHYKS+SP P  Q+ P++P    KH  +Q+LP  NTFV A
Sbjct: 917  GKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFV-A 974

Query: 1034 GDNISIGSDHCSE 1046
             D+IS  S   S+
Sbjct: 975  CDSISKCSSSSSD 987


>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
            sapiens]
          Length = 1025

 Score =  605 bits (1560), Expect = e-173
 Identities = 382/1033 (36%), Positives = 570/1033 (55%), Gaps = 95/1033 (9%)

Query: 36   YRLAEEGPADVRIGNVASDLGI-------VTGSGEVTFSLESGS-EYLKIDNLTGELSTS 87
            Y + EE P +V IG++  DL +       +T + +     ++G    ++I+  TGE+ T+
Sbjct: 28   YTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTT 87

Query: 88   ERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPV 147
              RIDREKL  C  I  +  CF + EV+++ P + +  L + + ++ DINDN P FP+ V
Sbjct: 88   GARIDREKL--CAGIPRDEHCFYEVEVAIL-PDEIF-RLVKIRFLIEDINDNAPLFPATV 143

Query: 148  LTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYP 207
            + +++ EN  + + Y LP A D D G NG++ YEL+          +S+     D    P
Sbjct: 144  INISIPENSAINSKYTLPAAVDPDVGINGVQNYELI----------KSQNIFGLDVIETP 193

Query: 208  GGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALD 267
             G                                 + +L V    D E++   ++K    
Sbjct: 194  EG-------------------------------DKMPQLIVQKELDREEKDTYVMK---- 218

Query: 268  REQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPI 327
                      ++V DGG P RSS AIL+V +TD NDN P F+++  E  + EN+  GT +
Sbjct: 219  ----------VKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSV 268

Query: 328  LQLRAADLDVGVNGQIEYVFGAATESV-RRLLRLDETSGWLSVLHRIDREEVNQLRFTVM 386
             QL A D D+G N +I + F     ++ RRL  L+ T+G +++   +DREE    +  V+
Sbjct: 269  TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVL 328

Query: 387  ARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQ 446
            A D G  P   +A V++N+ D NDNVPSI+IR I   P+ D V  ++E++ ++T IAL+ 
Sbjct: 329  ASDGGLMPA--RAMVLVNVTDVNDNVPSIDIRYIVN-PVNDTVV-LSENIPLNTKIALIT 384

Query: 447  VSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIV 506
            V+D+D   NG VTC    ++PF+L+P    +       + L T+  LDYE+T+E+ + ++
Sbjct: 385  VTDKDADHNGRVTCFTDHEIPFRLRPVFSNQ-------FLLETAAYLDYESTKEYAIKLL 437

Query: 507  AVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGK 566
            A D+G P L+ +  L +KV D NDN P+F QS V V  PENN PG ++  V A DADSG 
Sbjct: 438  AADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGP 497

Query: 567  NAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVI 626
            NA+I Y L       F++D  +G + V   LDRE+ D+Y F + AKD G+P L  + TV 
Sbjct: 498  NAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVF 557

Query: 627  VQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFS 686
            V + D+NDN P F  + + FYV ENL  +  VG++TV D D G N+ ++L I + N+ F+
Sbjct: 558  VSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFT 617

Query: 687  IENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-VTLP 745
            I++ TG I   +SFDRE Q +YTF VKA DGG   RS++A V++ V+D NDN P  +  P
Sbjct: 618  IDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPP 677

Query: 746  KNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVG 805
             N SY L+ PS+N  TVV  V+A D+D G+NA++ YSIVGGN   LF ID  +G ++L+ 
Sbjct: 678  SNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLME 737

Query: 806  KLTQKHYGLHRLVVQVNDSGQP-SQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQD 864
            K      GLHR++V+ ND GQP S  +  +V++FVNESV+NAT I+  + +S   P+T +
Sbjct: 738  KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPN 797

Query: 865  IAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFT 924
                     +   + I++  VAG +TV+++I I  + R CR           K + ++ T
Sbjct: 798  TEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVR-CRQAPHLKAAQKNKQNSEWAT 856

Query: 925  PQQHDKSKKPKKDKKNKKSKQP--LYSSIVTVEASKPNGQRYDSVNEKLS-----DSPSM 977
            P   ++     K KK KK   P  L  + VT+E +K +    D     L      +  +M
Sbjct: 857  PNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTM 916

Query: 978  GRYRSVNG----GPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGA 1033
            G+Y  V       P SPDLARHYKS+SP P  Q+ P++P    KH  +Q+LP  NTFV A
Sbjct: 917  GKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETP-LNSKHHIIQELPLDNTFV-A 974

Query: 1034 GDNISIGSDHCSE 1046
             D+IS  S   S+
Sbjct: 975  CDSISKCSSSSSD 987


>gi|190194360 protocadherin 20 [Homo sapiens]
          Length = 951

 Score =  405 bits (1041), Expect = e-112
 Identities = 295/920 (32%), Positives = 451/920 (49%), Gaps = 112/920 (12%)

Query: 26  SLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSG-------------------EVTF 66
           S + A +LL Y L E  PA V IG++A DL ++  S                     ++F
Sbjct: 61  SYSRATELL-YSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSF 119

Query: 67  SLES---GSEYLKIDNLTGELSTSERRIDREKL------------PQCQMIFDENECFLD 111
           SL S     +Y+ +DN +GEL TS + IDRE L                     + C L 
Sbjct: 120 SLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLL 179

Query: 112 FEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRD 171
            +V V+   Q +    + ++ + DINDN P FP   +++ V EN PV T           
Sbjct: 180 LDVLVL--PQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNT----------- 226

Query: 172 FGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEG 231
                                    R      A  P  G NG        + R LD    
Sbjct: 227 -------------------------RLAIEHPAVDPDVGINGVQ------TYRLLDYH-- 253

Query: 232 GGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQ 291
                      +F L V +  +GE+ P LIV GALDRE +D Y   +   DGG PP    
Sbjct: 254 ----------GMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGS 303

Query: 292 AILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAAT 351
           A L + I+D+NDN P F  S     +  N+  GTPI  ++A D D+G N QI Y +    
Sbjct: 304 ATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKV 363

Query: 352 -ESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDEND 410
            ++ + L  LDE +G + +  +I    +   + T++A   G  P     T +++I     
Sbjct: 364 PQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAV--ITALVSIIKVIF 421

Query: 411 NVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQL 470
             P I  R I      DGV  + E   V+TPIA   +  RD      V C + G+ PF+L
Sbjct: 422 RPPEIVPRYIANEI--DGVVYLKELEPVNTPIAFFTI--RDPEGKYKVNCYLDGEGPFRL 477

Query: 471 KPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTND 530
            P      +     Y L T+ P+DYE  + + V +VA +S          + V++ D ND
Sbjct: 478 SPYKPYNNE-----YLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDND 530

Query: 531 NPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGD 590
           N P+F Q ++E+   ENN P   +  + ATDADS +  +++Y L       F++D  +G 
Sbjct: 531 NAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGI 590

Query: 591 ILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKE 650
           + V+T LDRE+ ++Y + V A D G P  +   TV + V DKNDN P+F+   F+F+V E
Sbjct: 591 LTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPE 650

Query: 651 NLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTF 710
           N      +G+++V DAD GRN  ++L +   ++IF I+   G + + +S DRE Q++YT 
Sbjct: 651 NFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTL 710

Query: 711 RVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPK-NISYTLLPPSSNVRTVVATVLAT 769
            V+AVDGG+P  S+TA +++ ++D NDN P V  P+ N+SY L+ PS+   + V  V A 
Sbjct: 711 WVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAV 770

Query: 770 DSDDGINADLNYSIVG--GNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQP 827
           D D G+NA + YSI+G  G   + F IDP +G ++L   L Q  YGLHRL+V+V+D G P
Sbjct: 771 DKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYP 830

Query: 828 SQ-STTTLVHVFVNESVSNATAIDSQIARSLHIPLTQ---DIAGDPSYEISKQRLSIVIG 883
               +T +V++FVN++VSN + I+S + +   I + +    I+ +P++   +    +   
Sbjct: 831 EPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTL 890

Query: 884 VVAGIMTVILIILIVVMARY 903
           V   ++++  I L+  M  Y
Sbjct: 891 VALSVISLGSITLVTGMGIY 910


>gi|14270499 protocadherin gamma subfamily B, 4 isoform 2 precursor
           [Homo sapiens]
          Length = 803

 Score =  336 bits (861), Expect = 8e-92
 Identities = 230/731 (31%), Positives = 349/731 (47%), Gaps = 101/731 (13%)

Query: 20  LLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGI-VTGSGEVTFSLESGSEYLKID 78
           L  LSL   A  + +RYR+ EE P    +GN+A+DLG  V         + S   Y  + 
Sbjct: 19  LFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVS 78

Query: 79  NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDIND 138
             +GEL  S R +DRE++        +  C L+FE     P    ++ +   V + DIND
Sbjct: 79  AESGELLVSSR-LDREEI-----CGKKPACALEFEAVAENP----LNFYHVNVEIEDIND 128

Query: 139 NTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRA 198
           +TP F      L + E+   GT ++L +A D D G N ++ Y+L                
Sbjct: 129 HTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQL---------------- 172

Query: 199 GAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQP 258
                                                +P    S+   + +D   G K P
Sbjct: 173 -------------------------------------SPSDHFSLINKEKSD---GSKYP 192

Query: 259 QLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLA 318
           ++++K  LDRE++ SY LTL   D G PP SS A + VL+TD NDN+P F + VY   L+
Sbjct: 193 EMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLS 252

Query: 319 ENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEV 378
           EN  PGT +LQ+ A D D GVN +I + F  A++  +    L+  +G ++VL+ +D EEV
Sbjct: 253 ENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQ--FDLNSNTGEITVLNTLDFEEV 310

Query: 379 NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLV 438
            +    + ARD G      + TV + + DENDN P +  + +  +        + ED  +
Sbjct: 311 KEYSIVLEARDGG--GMIAQCTVEVEVIDENDNAPEVIFQSLPNL--------IMEDAEL 360

Query: 439 DTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEAT 498
            T IAL++V D+D   NG VTC + GDVPF++  +S       +  Y L T   LD E  
Sbjct: 361 GTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSS-------RNTYKLVTDAVLDREQN 413

Query: 499 REFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVL 558
            E+N+ + A D G P LSS++S+ + +GD NDN P+F QS   V+  ENN PG  ++ V 
Sbjct: 414 PEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVR 473

Query: 559 ATDADSGKNAEIAYSLDSS------VMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAK 612
           A+D D G N +++Y + +S      +    +I  +SG +      D EQ   +E  + A+
Sbjct: 474 ASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQAR 533

Query: 613 DKGIPVLQGSTTVIVQVADKNDNDPKFMQ-------DVFTFYVKENLQPNSPVGMVTVMD 665
           D+G P L  + ++ V V D+NDN P+ +              V    +P   V  V  +D
Sbjct: 534 DQGSPALSANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVD 593

Query: 666 ADKGRNAEMSLYIEENN--NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRS 723
           AD G NA +S ++ + +   +FS+   TG + +  +            V   DGG PP S
Sbjct: 594 ADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDGGQPPLS 653

Query: 724 ATATVSLFVMD 734
           ATAT+ L   D
Sbjct: 654 ATATLHLVFAD 664



 Score =  228 bits (582), Expect = 2e-59
 Identities = 175/662 (26%), Positives = 305/662 (46%), Gaps = 58/662 (8%)

Query: 259 QLIVKGALDREQRDSYE--LTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEAD 316
           +L+V   LDRE+    +    L      + P +   +  V I D+ND++P+F ++ +E  
Sbjct: 83  ELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHV-NVEIEDINDHTPKFTQNSFELQ 141

Query: 317 LAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGW----LSVLHR 372
           ++E++ PGT  +   A D D+G N    Y    +      L+  +++ G     + +   
Sbjct: 142 ISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHF--SLINKEKSDGSKYPEMVLKTP 199

Query: 373 IDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANV 432
           +DRE+      T+ A D G PP +  A + + + D NDN P    + + R+ L       
Sbjct: 200 LDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFS-QDVYRVSL------- 251

Query: 433 AEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASD-TEGDQNKKKYFLHTST 491
           +E+V   T +  V  +D+D+G N  +T        F    AS  T+ D N     +    
Sbjct: 252 SENVYPGTTVLQVTATDQDEGVNAEIT--------FSFSEASQITQFDLNSNTGEITVLN 303

Query: 492 PLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPP-MFGQSVVEVYFPENNIP 550
            LD+E  +E+++V+ A D G   + +  ++ V+V D NDN P +  QS+  +   +  + 
Sbjct: 304 TLDFEEVKEYSIVLEARDGGG--MIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAEL- 360

Query: 551 GERVATVLATDADSGKNAEIAYSLDSSV-MGIFAIDPDSGDILVNTVLDREQTDRYEFKV 609
           G  +A +   D DS  N E+   L+  V   I     ++  ++ + VLDREQ   Y   V
Sbjct: 361 GTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDAVLDREQNPEYNITV 420

Query: 610 NAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKG 669
            A D+G P L  S+++ + + D NDN P F Q  +  +V EN  P + +  V   D D G
Sbjct: 421 TATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLG 480

Query: 670 RNAEMSLYI-------EENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPR 722
            N ++S  I        E ++  SI  ++G +++  +FD E    +   ++A D G P  
Sbjct: 481 PNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPAL 540

Query: 723 SATATVSLFVMDENDNAPTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGINA 777
           SA  ++ + V D NDNAP V  P      +  + ++P ++    +V  V+A D+D G NA
Sbjct: 541 SANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNA 600

Query: 778 DLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 837
            L+Y ++  +   LF +   +G V     L  +     RL+V V D GQP  S T  +H+
Sbjct: 601 WLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLHL 660

Query: 838 FVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILI 897
              +S+                 +  DI   P     +  L   + V   +++V+ ++ +
Sbjct: 661 VFADSLQE---------------VLPDITDRPDPSDLQAELQFYLVVALALISVLFLVAM 705

Query: 898 VV 899
           ++
Sbjct: 706 IL 707



 Score =  110 bits (274), Expect = 9e-24
 Identities = 77/274 (28%), Positives = 134/274 (48%), Gaps = 19/274 (6%)

Query: 576 SSVMGIFAIDPDSGDILVNTVLDREQ------TDRYEFKVNAKDKGIPVLQGSTTVIVQV 629
           SS    F +  +SG++LV++ LDRE+          EF+  A++           V V++
Sbjct: 69  SSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENP-----LNFYHVNVEI 123

Query: 630 ADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENN--NIFSI 687
            D ND+ PKF Q+ F   + E+ QP +   + +  DAD G N   +  +  ++  ++ + 
Sbjct: 124 EDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINK 183

Query: 688 ENDTGTIYSTM----SFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVT 743
           E   G+ Y  M      DRE Q +Y   + A+D G PP S+TA + + V D NDNAP  +
Sbjct: 184 EKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFS 243

Query: 744 LPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSL 803
             +++    L  +    T V  V ATD D+G+NA++ +S    +    F+++  +G +++
Sbjct: 244 --QDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITV 301

Query: 804 VGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 837
           +  L  +    + +V++  D G      T  V V
Sbjct: 302 LNTLDFEEVKEYSIVLEARDGGGMIAQCTVEVEV 335


>gi|13470082 protocadherin gamma subfamily B, 4 isoform 1 precursor
           [Homo sapiens]
          Length = 923

 Score =  336 bits (861), Expect = 8e-92
 Identities = 230/731 (31%), Positives = 349/731 (47%), Gaps = 101/731 (13%)

Query: 20  LLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGI-VTGSGEVTFSLESGSEYLKID 78
           L  LSL   A  + +RYR+ EE P    +GN+A+DLG  V         + S   Y  + 
Sbjct: 19  LFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVS 78

Query: 79  NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDIND 138
             +GEL  S R +DRE++        +  C L+FE     P    ++ +   V + DIND
Sbjct: 79  AESGELLVSSR-LDREEI-----CGKKPACALEFEAVAENP----LNFYHVNVEIEDIND 128

Query: 139 NTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRA 198
           +TP F      L + E+   GT ++L +A D D G N ++ Y+L                
Sbjct: 129 HTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQL---------------- 172

Query: 199 GAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQP 258
                                                +P    S+   + +D   G K P
Sbjct: 173 -------------------------------------SPSDHFSLINKEKSD---GSKYP 192

Query: 259 QLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLA 318
           ++++K  LDRE++ SY LTL   D G PP SS A + VL+TD NDN+P F + VY   L+
Sbjct: 193 EMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLS 252

Query: 319 ENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEV 378
           EN  PGT +LQ+ A D D GVN +I + F  A++  +    L+  +G ++VL+ +D EEV
Sbjct: 253 ENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQ--FDLNSNTGEITVLNTLDFEEV 310

Query: 379 NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLV 438
            +    + ARD G      + TV + + DENDN P +  + +  +        + ED  +
Sbjct: 311 KEYSIVLEARDGG--GMIAQCTVEVEVIDENDNAPEVIFQSLPNL--------IMEDAEL 360

Query: 439 DTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEAT 498
            T IAL++V D+D   NG VTC + GDVPF++  +S       +  Y L T   LD E  
Sbjct: 361 GTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSS-------RNTYKLVTDAVLDREQN 413

Query: 499 REFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVL 558
            E+N+ + A D G P LSS++S+ + +GD NDN P+F QS   V+  ENN PG  ++ V 
Sbjct: 414 PEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVR 473

Query: 559 ATDADSGKNAEIAYSLDSS------VMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAK 612
           A+D D G N +++Y + +S      +    +I  +SG +      D EQ   +E  + A+
Sbjct: 474 ASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQAR 533

Query: 613 DKGIPVLQGSTTVIVQVADKNDNDPKFMQ-------DVFTFYVKENLQPNSPVGMVTVMD 665
           D+G P L  + ++ V V D+NDN P+ +              V    +P   V  V  +D
Sbjct: 534 DQGSPALSANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVD 593

Query: 666 ADKGRNAEMSLYIEENN--NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRS 723
           AD G NA +S ++ + +   +FS+   TG + +  +            V   DGG PP S
Sbjct: 594 ADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDGGQPPLS 653

Query: 724 ATATVSLFVMD 734
           ATAT+ L   D
Sbjct: 654 ATATLHLVFAD 664



 Score =  228 bits (582), Expect = 2e-59
 Identities = 175/662 (26%), Positives = 305/662 (46%), Gaps = 58/662 (8%)

Query: 259 QLIVKGALDREQRDSYE--LTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEAD 316
           +L+V   LDRE+    +    L      + P +   +  V I D+ND++P+F ++ +E  
Sbjct: 83  ELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHV-NVEIEDINDHTPKFTQNSFELQ 141

Query: 317 LAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGW----LSVLHR 372
           ++E++ PGT  +   A D D+G N    Y    +      L+  +++ G     + +   
Sbjct: 142 ISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHF--SLINKEKSDGSKYPEMVLKTP 199

Query: 373 IDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANV 432
           +DRE+      T+ A D G PP +  A + + + D NDN P    + + R+ L       
Sbjct: 200 LDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFS-QDVYRVSL------- 251

Query: 433 AEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASD-TEGDQNKKKYFLHTST 491
           +E+V   T +  V  +D+D+G N  +T        F    AS  T+ D N     +    
Sbjct: 252 SENVYPGTTVLQVTATDQDEGVNAEIT--------FSFSEASQITQFDLNSNTGEITVLN 303

Query: 492 PLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPP-MFGQSVVEVYFPENNIP 550
            LD+E  +E+++V+ A D G   + +  ++ V+V D NDN P +  QS+  +   +  + 
Sbjct: 304 TLDFEEVKEYSIVLEARDGGG--MIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAEL- 360

Query: 551 GERVATVLATDADSGKNAEIAYSLDSSV-MGIFAIDPDSGDILVNTVLDREQTDRYEFKV 609
           G  +A +   D DS  N E+   L+  V   I     ++  ++ + VLDREQ   Y   V
Sbjct: 361 GTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDAVLDREQNPEYNITV 420

Query: 610 NAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKG 669
            A D+G P L  S+++ + + D NDN P F Q  +  +V EN  P + +  V   D D G
Sbjct: 421 TATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLG 480

Query: 670 RNAEMSLYI-------EENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPR 722
            N ++S  I        E ++  SI  ++G +++  +FD E    +   ++A D G P  
Sbjct: 481 PNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPAL 540

Query: 723 SATATVSLFVMDENDNAPTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGINA 777
           SA  ++ + V D NDNAP V  P      +  + ++P ++    +V  V+A D+D G NA
Sbjct: 541 SANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNA 600

Query: 778 DLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 837
            L+Y ++  +   LF +   +G V     L  +     RL+V V D GQP  S T  +H+
Sbjct: 601 WLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLHL 660

Query: 838 FVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILI 897
              +S+                 +  DI   P     +  L   + V   +++V+ ++ +
Sbjct: 661 VFADSLQE---------------VLPDITDRPDPSDLQAELQFYLVVALALISVLFLVAM 705

Query: 898 VV 899
           ++
Sbjct: 706 IL 707



 Score =  110 bits (274), Expect = 9e-24
 Identities = 77/274 (28%), Positives = 134/274 (48%), Gaps = 19/274 (6%)

Query: 576 SSVMGIFAIDPDSGDILVNTVLDREQ------TDRYEFKVNAKDKGIPVLQGSTTVIVQV 629
           SS    F +  +SG++LV++ LDRE+          EF+  A++           V V++
Sbjct: 69  SSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENP-----LNFYHVNVEI 123

Query: 630 ADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENN--NIFSI 687
            D ND+ PKF Q+ F   + E+ QP +   + +  DAD G N   +  +  ++  ++ + 
Sbjct: 124 EDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINK 183

Query: 688 ENDTGTIYSTM----SFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVT 743
           E   G+ Y  M      DRE Q +Y   + A+D G PP S+TA + + V D NDNAP  +
Sbjct: 184 EKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFS 243

Query: 744 LPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSL 803
             +++    L  +    T V  V ATD D+G+NA++ +S    +    F+++  +G +++
Sbjct: 244 --QDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITV 301

Query: 804 VGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 837
           +  L  +    + +V++  D G      T  V V
Sbjct: 302 LNTLDFEEVKEYSIVLEARDGGGMIAQCTVEVEV 335


>gi|14270508 protocadherin gamma subfamily B, 7 isoform 2 precursor
           [Homo sapiens]
          Length = 808

 Score =  330 bits (845), Expect = 6e-90
 Identities = 229/734 (31%), Positives = 344/734 (46%), Gaps = 105/734 (14%)

Query: 19  LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVT---GSGEVTFSLESGSEYL 75
           LLLPL        + +RY + EE      +GN+A DLG+      + E+  S E    + 
Sbjct: 20  LLLPLFYPTLC--EPIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARELRVSAEK--LHF 75

Query: 76  KIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLD 135
            +D  +G+L   +R IDRE++  C+   +   C L  E  V  P    +++F   V++ D
Sbjct: 76  SVDAQSGDLLVKDR-IDREQI--CK---ERRRCELQLEAVVENP----LNIFHVIVVIED 125

Query: 136 INDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGES 195
           +ND+ P F    + L + E+  +G   +L +A D D   N +                  
Sbjct: 126 VNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSL------------------ 167

Query: 196 RRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGE 255
                                     SK +L  +E             F L   D PDG 
Sbjct: 168 --------------------------SKYQLSPNE------------YFSLVEKDNPDGG 189

Query: 256 KQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEA 315
           K P+L+++  LDRE + ++ L L   DGGDPPRS  A +R+L+ D NDN P F + VY  
Sbjct: 190 KYPELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRV 249

Query: 316 DLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDR 375
            L E+  PGT IL+++A D D G+N +I Y F    +  + +  LD T+G +     +D 
Sbjct: 250 SLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDF 309

Query: 376 EEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAED 435
           EEV +    + A+DRG    + +  V++ + DENDN P I I  +    ++D    V   
Sbjct: 310 EEVERYTINIEAKDRGS--LSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVV-- 365

Query: 436 VLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDY 495
                 +AL +  D+D GENG V C++   VPF++  +S+         Y L T   LD 
Sbjct: 366 ------VALFKTRDQDSGENGEVRCSLSRGVPFKIHSSSN-------NYYKLVTDEALDR 412

Query: 496 EATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVA 555
           E T E+NV I A D G P LSS+ ++ + + D NDN P+FGQS   V+ PENN PG  +A
Sbjct: 413 EQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIA 472

Query: 556 TVLATDADSGKNAEIAYSLDSS------VMGIFAIDPDSGDILVNTVLDREQTDRYEFKV 609
            V A+D D G N  ++YSL +S      +    ++   SG +      D EQ   +E  +
Sbjct: 473 QVSASDPDFGLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTL 532

Query: 610 NAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQ-------DVFTFYVKENLQPNSPVGMVT 662
            A+D+G P L  + ++ V V D+NDN P+ +              V    QP   V  V 
Sbjct: 533 QARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVV 592

Query: 663 VMDADKGRNAEMSLYIEENN--NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720
            +DAD G NA +S ++ + +   +FS+   TG +    +   +        V   DGG P
Sbjct: 593 AVDADSGHNAWLSYHVVQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVRDGGQP 652

Query: 721 PRSATATVSLFVMD 734
           P SATAT+ L   D
Sbjct: 653 PLSATATLHLVFAD 666



 Score =  241 bits (616), Expect = 2e-63
 Identities = 194/679 (28%), Positives = 316/679 (46%), Gaps = 61/679 (8%)

Query: 260 LIVKGALDREQ--RDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317
           L+VK  +DREQ  ++     L++    + P +   ++ V+I DVND++P+F K     ++
Sbjct: 84  LLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVI-VVIEDVNDHAPQFRKDEINLEI 142

Query: 318 AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGW----LSVLHRI 373
           +E+ + G   +   A D D+ +N   +Y    +      L+  D   G     L +   +
Sbjct: 143 SESVSLGMGTILESAEDPDISMNSLSKYQL--SPNEYFSLVEKDNPDGGKYPELVLQKTL 200

Query: 374 DREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVA 433
           DRE  +     + A D G PP++  A + + + D NDN P +  + + R+ L+       
Sbjct: 201 DRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDN-PPVFSQDVYRVSLR------- 252

Query: 434 EDVLVDTPIALVQVSDRDQGENGVVTCTVVG--DVPFQLKPASDTEGDQNKKKYFLHTST 491
           EDV   T I  V+ +D+D+G N  +T +  G  D    +     T G+       + T  
Sbjct: 253 EDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGN-------ILTQQ 305

Query: 492 PLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPG 551
           PLD+E    + + I A D GS  LS+   +IV+V D NDN P    + +     E++ PG
Sbjct: 306 PLDFEEVERYTINIEAKDRGS--LSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPG 363

Query: 552 ERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGD---ILVNTVLDREQTDRYEFK 608
             VA     D DSG+N E+  SL   V   F I   S +   ++ +  LDREQT  Y   
Sbjct: 364 VVVALFKTRDQDSGENGEVRCSLSRGVP--FKIHSSSNNYYKLVTDEALDREQTPEYNVT 421

Query: 609 VNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADK 668
           + A D+G P L  S T+ + + D NDN P F Q  +  +V EN QP + +  V+  D D 
Sbjct: 422 IAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDF 481

Query: 669 GRNAEMSLYIEENN-------NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPP 721
           G N  +S  +  ++       +  S+   +G +++  +FD E   T+   ++A D G P 
Sbjct: 482 GLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPA 541

Query: 722 RSATATVSLFVMDENDNAPTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGIN 776
            SA  ++ + V D NDNAP V  P      +  +  +P ++    +V  V+A D+D G N
Sbjct: 542 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHN 601

Query: 777 ADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVH 836
           A L+Y +V  +   LF +   +G V +V  L  K     RL+V V D GQP  S T  +H
Sbjct: 602 AWLSYHVVQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVRDGGQPPLSATATLH 661

Query: 837 VFVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIIL 896
           +   +S+                 +  D +  P+   S+  +   + VVA  +  +L +L
Sbjct: 662 LVFADSLQE---------------VLPDFSDHPTPSDSQAEMQFYL-VVALALISVLFLL 705

Query: 897 IVVMARYCRSKNKNGYEAG 915
            V++A   R +      AG
Sbjct: 706 AVILAIALRLRQSFSPTAG 724



 Score =  186 bits (471), Expect = 1e-46
 Identities = 139/501 (27%), Positives = 221/501 (44%), Gaps = 26/501 (5%)

Query: 360 LDETSGWLSVLHRIDREEV-NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIR 418
           +D  SG L V  RIDRE++  + R   +  +       +   V++ I+D ND+ P     
Sbjct: 77  VDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFRKD 136

Query: 419 KIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEG 478
           +I           ++E V +     L    D D   N +    +  +  F L    + +G
Sbjct: 137 EIN--------LEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDG 188

Query: 479 DQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQS 538
            +  +     T   LD E     ++V+ A+D G P  S    + + V D NDNPP+F Q 
Sbjct: 189 GKYPELVLQKT---LDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQD 245

Query: 539 VVEVYFPENNIPGERVATVLATDADSGKNAEIAYS---LDSSVMGIFAIDPDSGDILVNT 595
           V  V   E+  PG  +  V ATD D G N+EI YS   +      +F++D  +G+IL   
Sbjct: 246 VYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQ 305

Query: 596 VLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPN 655
            LD E+ +RY   + AKD+G   L     VIV+V D+NDN P+ +    +  + E+  P 
Sbjct: 306 PLDFEEVERYTINIEAKDRG--SLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPG 363

Query: 656 SPVGMVTVMDADKGRNAEMSLYIEEN--NNIFSIENDTGTIYSTMSFDREHQTTYTFRVK 713
             V +    D D G N E+   +       I S  N+   + +  + DRE    Y   + 
Sbjct: 364 VVVALFKTRDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIA 423

Query: 714 AVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDD 773
           A D G PP S++ T++L + D NDNAP     ++     +P ++     +A V A+D D 
Sbjct: 424 ATDRGKPPLSSSKTITLHITDVNDNAP--VFGQSAYLVHVPENNQPGASIAQVSASDPDF 481

Query: 774 GINADLNYSIVGGN-----PFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPS 828
           G+N  ++YS++  +           +   SGVV        +      L +Q  D G P+
Sbjct: 482 GLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPA 541

Query: 829 QSTTTLVHVFVNESVSNATAI 849
            S    + V V +   NA  +
Sbjct: 542 LSANVSLRVLVGDRNDNAPRV 562



 Score =  103 bits (257), Expect = 9e-22
 Identities = 80/273 (29%), Positives = 133/273 (48%), Gaps = 27/273 (9%)

Query: 582 FAIDPDSGDILVNTVLDREQ----TDRYEFKVNA-KDKGIPVLQGSTTVIVQVADKNDND 636
           F++D  SGD+LV   +DREQ      R E ++ A  +  + +      VIV + D ND+ 
Sbjct: 75  FSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFH----VIVVIEDVNDHA 130

Query: 637 PKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEM---SLYIEENNNIFSI---END 690
           P+F +D     + E++     +GM T++++ +  +  M   S Y    N  FS+   +N 
Sbjct: 131 PQFRKDEINLEISESVS----LGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNP 186

Query: 691 TGTIYSTM----SFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPK 746
            G  Y  +    + DRE Q+ +   + A+DGGDPPRS TA + + V+D NDN P  +  +
Sbjct: 187 DGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFS--Q 244

Query: 747 NISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVG--GNPFKLFEIDPTSGVVSLV 804
           ++    L       T +  V ATD D+GIN+++ YS  G       +F +D T+G +   
Sbjct: 245 DVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQ 304

Query: 805 GKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 837
             L  +    + + ++  D G  S     +V V
Sbjct: 305 QPLDFEEVERYTINIEAKDRGSLSTRCKVIVEV 337


>gi|11128027 protocadherin gamma subfamily B, 7 isoform 1 precursor
           [Homo sapiens]
          Length = 929

 Score =  330 bits (845), Expect = 6e-90
 Identities = 229/734 (31%), Positives = 344/734 (46%), Gaps = 105/734 (14%)

Query: 19  LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVT---GSGEVTFSLESGSEYL 75
           LLLPL        + +RY + EE      +GN+A DLG+      + E+  S E    + 
Sbjct: 20  LLLPLFYPTLC--EPIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARELRVSAEK--LHF 75

Query: 76  KIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLD 135
            +D  +G+L   +R IDRE++  C+   +   C L  E  V  P    +++F   V++ D
Sbjct: 76  SVDAQSGDLLVKDR-IDREQI--CK---ERRRCELQLEAVVENP----LNIFHVIVVIED 125

Query: 136 INDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGES 195
           +ND+ P F    + L + E+  +G   +L +A D D   N +                  
Sbjct: 126 VNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSL------------------ 167

Query: 196 RRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGE 255
                                     SK +L  +E             F L   D PDG 
Sbjct: 168 --------------------------SKYQLSPNE------------YFSLVEKDNPDGG 189

Query: 256 KQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEA 315
           K P+L+++  LDRE + ++ L L   DGGDPPRS  A +R+L+ D NDN P F + VY  
Sbjct: 190 KYPELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRV 249

Query: 316 DLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDR 375
            L E+  PGT IL+++A D D G+N +I Y F    +  + +  LD T+G +     +D 
Sbjct: 250 SLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDF 309

Query: 376 EEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAED 435
           EEV +    + A+DRG    + +  V++ + DENDN P I I  +    ++D    V   
Sbjct: 310 EEVERYTINIEAKDRGS--LSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVV-- 365

Query: 436 VLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDY 495
                 +AL +  D+D GENG V C++   VPF++  +S+         Y L T   LD 
Sbjct: 366 ------VALFKTRDQDSGENGEVRCSLSRGVPFKIHSSSN-------NYYKLVTDEALDR 412

Query: 496 EATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVA 555
           E T E+NV I A D G P LSS+ ++ + + D NDN P+FGQS   V+ PENN PG  +A
Sbjct: 413 EQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIA 472

Query: 556 TVLATDADSGKNAEIAYSLDSS------VMGIFAIDPDSGDILVNTVLDREQTDRYEFKV 609
            V A+D D G N  ++YSL +S      +    ++   SG +      D EQ   +E  +
Sbjct: 473 QVSASDPDFGLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTL 532

Query: 610 NAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQ-------DVFTFYVKENLQPNSPVGMVT 662
            A+D+G P L  + ++ V V D+NDN P+ +              V    QP   V  V 
Sbjct: 533 QARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVV 592

Query: 663 VMDADKGRNAEMSLYIEENN--NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP 720
            +DAD G NA +S ++ + +   +FS+   TG +    +   +        V   DGG P
Sbjct: 593 AVDADSGHNAWLSYHVVQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVRDGGQP 652

Query: 721 PRSATATVSLFVMD 734
           P SATAT+ L   D
Sbjct: 653 PLSATATLHLVFAD 666



 Score =  241 bits (616), Expect = 2e-63
 Identities = 194/679 (28%), Positives = 316/679 (46%), Gaps = 61/679 (8%)

Query: 260 LIVKGALDREQ--RDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317
           L+VK  +DREQ  ++     L++    + P +   ++ V+I DVND++P+F K     ++
Sbjct: 84  LLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVI-VVIEDVNDHAPQFRKDEINLEI 142

Query: 318 AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGW----LSVLHRI 373
           +E+ + G   +   A D D+ +N   +Y    +      L+  D   G     L +   +
Sbjct: 143 SESVSLGMGTILESAEDPDISMNSLSKYQL--SPNEYFSLVEKDNPDGGKYPELVLQKTL 200

Query: 374 DREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVA 433
           DRE  +     + A D G PP++  A + + + D NDN P +  + + R+ L+       
Sbjct: 201 DRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDN-PPVFSQDVYRVSLR------- 252

Query: 434 EDVLVDTPIALVQVSDRDQGENGVVTCTVVG--DVPFQLKPASDTEGDQNKKKYFLHTST 491
           EDV   T I  V+ +D+D+G N  +T +  G  D    +     T G+       + T  
Sbjct: 253 EDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGN-------ILTQQ 305

Query: 492 PLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPG 551
           PLD+E    + + I A D GS  LS+   +IV+V D NDN P    + +     E++ PG
Sbjct: 306 PLDFEEVERYTINIEAKDRGS--LSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPG 363

Query: 552 ERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGD---ILVNTVLDREQTDRYEFK 608
             VA     D DSG+N E+  SL   V   F I   S +   ++ +  LDREQT  Y   
Sbjct: 364 VVVALFKTRDQDSGENGEVRCSLSRGVP--FKIHSSSNNYYKLVTDEALDREQTPEYNVT 421

Query: 609 VNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADK 668
           + A D+G P L  S T+ + + D NDN P F Q  +  +V EN QP + +  V+  D D 
Sbjct: 422 IAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDF 481

Query: 669 GRNAEMSLYIEENN-------NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPP 721
           G N  +S  +  ++       +  S+   +G +++  +FD E   T+   ++A D G P 
Sbjct: 482 GLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPA 541

Query: 722 RSATATVSLFVMDENDNAPTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGIN 776
            SA  ++ + V D NDNAP V  P      +  +  +P ++    +V  V+A D+D G N
Sbjct: 542 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHN 601

Query: 777 ADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVH 836
           A L+Y +V  +   LF +   +G V +V  L  K     RL+V V D GQP  S T  +H
Sbjct: 602 AWLSYHVVQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVRDGGQPPLSATATLH 661

Query: 837 VFVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIIL 896
           +   +S+                 +  D +  P+   S+  +   + VVA  +  +L +L
Sbjct: 662 LVFADSLQE---------------VLPDFSDHPTPSDSQAEMQFYL-VVALALISVLFLL 705

Query: 897 IVVMARYCRSKNKNGYEAG 915
            V++A   R +      AG
Sbjct: 706 AVILAIALRLRQSFSPTAG 724



 Score =  186 bits (471), Expect = 1e-46
 Identities = 139/501 (27%), Positives = 221/501 (44%), Gaps = 26/501 (5%)

Query: 360 LDETSGWLSVLHRIDREEV-NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIR 418
           +D  SG L V  RIDRE++  + R   +  +       +   V++ I+D ND+ P     
Sbjct: 77  VDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFRKD 136

Query: 419 KIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEG 478
           +I           ++E V +     L    D D   N +    +  +  F L    + +G
Sbjct: 137 EIN--------LEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDG 188

Query: 479 DQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQS 538
            +  +     T   LD E     ++V+ A+D G P  S    + + V D NDNPP+F Q 
Sbjct: 189 GKYPELVLQKT---LDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQD 245

Query: 539 VVEVYFPENNIPGERVATVLATDADSGKNAEIAYS---LDSSVMGIFAIDPDSGDILVNT 595
           V  V   E+  PG  +  V ATD D G N+EI YS   +      +F++D  +G+IL   
Sbjct: 246 VYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQ 305

Query: 596 VLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPN 655
            LD E+ +RY   + AKD+G   L     VIV+V D+NDN P+ +    +  + E+  P 
Sbjct: 306 PLDFEEVERYTINIEAKDRG--SLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPG 363

Query: 656 SPVGMVTVMDADKGRNAEMSLYIEEN--NNIFSIENDTGTIYSTMSFDREHQTTYTFRVK 713
             V +    D D G N E+   +       I S  N+   + +  + DRE    Y   + 
Sbjct: 364 VVVALFKTRDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIA 423

Query: 714 AVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDD 773
           A D G PP S++ T++L + D NDNAP     ++     +P ++     +A V A+D D 
Sbjct: 424 ATDRGKPPLSSSKTITLHITDVNDNAP--VFGQSAYLVHVPENNQPGASIAQVSASDPDF 481

Query: 774 GINADLNYSIVGGN-----PFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPS 828
           G+N  ++YS++  +           +   SGVV        +      L +Q  D G P+
Sbjct: 482 GLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPA 541

Query: 829 QSTTTLVHVFVNESVSNATAI 849
            S    + V V +   NA  +
Sbjct: 542 LSANVSLRVLVGDRNDNAPRV 562



 Score =  103 bits (257), Expect = 9e-22
 Identities = 80/273 (29%), Positives = 133/273 (48%), Gaps = 27/273 (9%)

Query: 582 FAIDPDSGDILVNTVLDREQ----TDRYEFKVNA-KDKGIPVLQGSTTVIVQVADKNDND 636
           F++D  SGD+LV   +DREQ      R E ++ A  +  + +      VIV + D ND+ 
Sbjct: 75  FSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFH----VIVVIEDVNDHA 130

Query: 637 PKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEM---SLYIEENNNIFSI---END 690
           P+F +D     + E++     +GM T++++ +  +  M   S Y    N  FS+   +N 
Sbjct: 131 PQFRKDEINLEISESVS----LGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNP 186

Query: 691 TGTIYSTM----SFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPK 746
            G  Y  +    + DRE Q+ +   + A+DGGDPPRS TA + + V+D NDN P  +  +
Sbjct: 187 DGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFS--Q 244

Query: 747 NISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVG--GNPFKLFEIDPTSGVVSLV 804
           ++    L       T +  V ATD D+GIN+++ YS  G       +F +D T+G +   
Sbjct: 245 DVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQ 304

Query: 805 GKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 837
             L  +    + + ++  D G  S     +V V
Sbjct: 305 QPLDFEEVERYTINIEAKDRGSLSTRCKVIVEV 337


>gi|14277685 protocadherin gamma subfamily C, 5 isoform 2 precursor
           [Homo sapiens]
          Length = 878

 Score =  322 bits (825), Expect = 1e-87
 Identities = 234/758 (30%), Positives = 348/758 (45%), Gaps = 106/758 (13%)

Query: 34  LRYRLAEEGPADVRIGNVASDLGIVTG---SGEVTFSLESGSEYLKIDNLTGELSTSERR 90
           LRY + EE      +GNVA DLG+      S  +    E    Y  +  ++G L+ +++ 
Sbjct: 31  LRYSVVEESEPGTLVGNVAQDLGLKMTDLLSRRLQLGSEENGRYFSLSLMSGALAVNQK- 89

Query: 91  IDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTL 150
           IDRE L           C L  +V    P    ++L   +V +LD+NDN+P+F +P   +
Sbjct: 90  IDRESLCGAS-----TSCLLPVQVVTEHP----LELIRVEVEILDLNDNSPSFATPEREM 140

Query: 151 TVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGG 210
            + E+   G  + L                                     DSA  P  G
Sbjct: 141 RISESAASGARFPL-------------------------------------DSAQDPDVG 163

Query: 211 GNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQ 270
            N  S                         +S F L V    DG+  P+L+++  LDRE 
Sbjct: 164 TNTVS-------------------FYTLSPNSHFSLNVKTLKDGKPFPELVLEQQLDREA 204

Query: 271 RDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQL 330
           +  ++L L   DGG P RS   ++ V++ D+NDN+P F+ SV    + EN+  GT +L+L
Sbjct: 205 QARHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPIGTLLLRL 264

Query: 331 RAADLDVGVNGQIEYVFGAAT-ESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARD 389
            A D D G NGQ++Y FG  T E+VR L  LD +SG + VL  ID EE         ARD
Sbjct: 265 NATDPDEGTNGQLDYSFGDHTSEAVRNLFGLDPSSGAIHVLGPIDFEESRFYEIHARARD 324

Query: 390 RGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSD 449
           +GQP       + +++ D NDN P + +  +           V E   V T + L  V D
Sbjct: 325 QGQPAMEGHCVIQVDVGDVNDNAPEVLLASLAN--------PVLESTPVGTVVGLFNVRD 376

Query: 450 RDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVD 509
           RD G NG V+  +  D+PFQ+KP        ++  Y L TS PLD EAT  + + ++A D
Sbjct: 377 RDSGRNGEVSLDISPDLPFQIKP--------SENHYSLLTSQPLDREATSHYIIELLASD 428

Query: 510 SGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAE 569
           +GSPSL  + ++ + + D NDN P F Q +   Y  EN  PG  + TV A+D D+G NA 
Sbjct: 429 AGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNAR 488

Query: 570 IAYSL-DSSVMGIFA-----IDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGST 623
           + YS+  + V G  A     ++P+ G I      D E     +  V  +D G P L  +T
Sbjct: 489 LTYSIVGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPLHANT 548

Query: 624 TVIVQVADKNDNDPKFM------QDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLY 677
           ++ V V D+NDN P  +      +      +  +  P S V  VT +DAD G NA +S  
Sbjct: 549 SLHVFVLDENDNAPAVLHPRPDWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYS 608

Query: 678 IEENN---NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMD 734
           +   +    +F +   TG + +  +   +   T    V   D GDP  S+TATV L + D
Sbjct: 609 LLPQSTAPGLFLVSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLED 668

Query: 735 ENDNAPTVTLPKNISYTLLPPS-SNVRTVVATVLATDS 771
           E+       +PK+  + + PP  S++   +   LAT S
Sbjct: 669 EDPE----EMPKSSDFLIHPPERSDLTLYLIVALATVS 702



 Score =  208 bits (529), Expect = 3e-53
 Identities = 178/649 (27%), Positives = 290/649 (44%), Gaps = 67/649 (10%)

Query: 294 LRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATES 353
           + V I D+NDNSP F     E  ++E++A G       A D DVG N    Y     +  
Sbjct: 119 VEVEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNSHF 178

Query: 354 VRRLLRLDETSGW--LSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDN 411
              +  L +   +  L +  ++DRE   + +  + A D G P ++    + + + D NDN
Sbjct: 179 SLNVKTLKDGKPFPELVLEQQLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDN 238

Query: 412 VPSIE--IRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVV-------TCTV 462
            P+ +  + ++G          + E+  + T +  +  +D D+G NG +       T   
Sbjct: 239 APTFQSSVLRVG----------IPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEA 288

Query: 463 VGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLI 522
           V ++ F L P+S            +H   P+D+E +R + +   A D G P++  +  + 
Sbjct: 289 VRNL-FGLDPSSGA----------IHVLGPIDFEESRFYEIHARARDQGQPAMEGHCVIQ 337

Query: 523 VKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIF 582
           V VGD NDN P    + +     E+   G  V      D DSG+N E+  SLD S    F
Sbjct: 338 VDVGDVNDNAPEVLLASLANPVLESTPVGTVVGLFNVRDRDSGRNGEV--SLDISPDLPF 395

Query: 583 AIDPDSG--DILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFM 640
            I P      +L +  LDRE T  Y  ++ A D G P L    T+ + ++D NDN P+F 
Sbjct: 396 QIKPSENHYSLLTSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDVNDNAPRFN 455

Query: 641 QDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEEN-------NNIFSIENDTGT 693
           Q ++T Y+ EN  P S +  V   D D G NA ++  I  N       ++   +  + G 
Sbjct: 456 QQLYTAYILENRPPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFVYVNPEDGR 515

Query: 694 IYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPK----NIS 749
           I++  +FD E        V   D G PP  A  ++ +FV+DENDNAP V  P+    + +
Sbjct: 516 IFAQRTFDYELLQMLQIVVGVRDSGSPPLHANTSLHVFVLDENDNAPAVLHPRPDWEHSA 575

Query: 750 YTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFK-LFEIDPTSGVVSLVGKLT 808
              LP S+   ++V  V A D+D G NA L+YS++  +    LF +   +G V     L 
Sbjct: 576 PQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSTHTGEVRTARALL 635

Query: 809 QKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQDIAGD 868
           +      ++VV V D+G PS S+T  V + + +                 +P + D    
Sbjct: 636 EDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDPE------------EMPKSSDFLIH 683

Query: 869 PSYEISKQRLSIVIGVVAGIMTVILIILI--VVMARYCRSKNKNGYEAG 915
           P      +R  + + ++  + TV L+ L+    ++  C   N +G   G
Sbjct: 684 P-----PERSDLTLYLIVALATVSLLSLVTFTFLSAKCLQGNADGDGGG 727



 Score =  102 bits (253), Expect = 3e-21
 Identities = 79/286 (27%), Positives = 129/286 (45%), Gaps = 28/286 (9%)

Query: 582 FAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTT-------VIVQVADKND 634
           F++   SG + VN  +DRE          A    +  +Q  T        V V++ D ND
Sbjct: 75  FSLSLMSGALAVNQKIDRESL------CGASTSCLLPVQVVTEHPLELIRVEVEILDLND 128

Query: 635 NDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDT--- 691
           N P F        + E+    +   + +  D D G N  +S Y    N+ FS+   T   
Sbjct: 129 NSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNT-VSFYTLSPNSHFSLNVKTLKD 187

Query: 692 ----GTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKN 747
                 +      DRE Q  +   + AVDGG P RS T  +S+ V+D NDNAPT     +
Sbjct: 188 GKPFPELVLEQQLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPT--FQSS 245

Query: 748 ISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFK----LFEIDPTSGVVSL 803
           +    +P ++ + T++  + ATD D+G N  L+YS  G +  +    LF +DP+SG + +
Sbjct: 246 VLRVGIPENAPIGTLLLRLNATDPDEGTNGQLDYSF-GDHTSEAVRNLFGLDPSSGAIHV 304

Query: 804 VGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAI 849
           +G +  +    + +  +  D GQP+     ++ V V +   NA  +
Sbjct: 305 LGPIDFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEV 350



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 56/221 (25%), Positives = 91/221 (41%), Gaps = 16/221 (7%)

Query: 646 FYVKENLQPNSPVGMVTV---MDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDR 702
           + V E  +P + VG V     +      +  + L  EEN   FS+   +G +      DR
Sbjct: 33  YSVVEESEPGTLVGNVAQDLGLKMTDLLSRRLQLGSEENGRYFSLSLMSGALAVNQKIDR 92

Query: 703 EH----QTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSN 758
           E      T+    V+ V   + P      V + ++D NDN+P+   P+         +S 
Sbjct: 93  ESLCGASTSCLLPVQVVT--EHPLE-LIRVEVEILDLNDNSPSFATPEREMRISESAASG 149

Query: 759 VRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSG----VVSLVGKLTQKHYGL 814
            R  + +  A D D G N    Y++   + F L       G     + L  +L ++    
Sbjct: 150 ARFPLDS--AQDPDVGTNTVSFYTLSPNSHFSLNVKTLKDGKPFPELVLEQQLDREAQAR 207

Query: 815 HRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIAR 855
           H+LV+   D G P++S TTL+ V V +   NA    S + R
Sbjct: 208 HQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLR 248


>gi|11128023 protocadherin gamma subfamily C, 5 isoform 1 precursor
           [Homo sapiens]
          Length = 944

 Score =  322 bits (825), Expect = 1e-87
 Identities = 234/758 (30%), Positives = 348/758 (45%), Gaps = 106/758 (13%)

Query: 34  LRYRLAEEGPADVRIGNVASDLGIVTG---SGEVTFSLESGSEYLKIDNLTGELSTSERR 90
           LRY + EE      +GNVA DLG+      S  +    E    Y  +  ++G L+ +++ 
Sbjct: 31  LRYSVVEESEPGTLVGNVAQDLGLKMTDLLSRRLQLGSEENGRYFSLSLMSGALAVNQK- 89

Query: 91  IDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTL 150
           IDRE L           C L  +V    P    ++L   +V +LD+NDN+P+F +P   +
Sbjct: 90  IDRESLCGAS-----TSCLLPVQVVTEHP----LELIRVEVEILDLNDNSPSFATPEREM 140

Query: 151 TVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGG 210
            + E+   G  + L                                     DSA  P  G
Sbjct: 141 RISESAASGARFPL-------------------------------------DSAQDPDVG 163

Query: 211 GNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQ 270
            N  S                         +S F L V    DG+  P+L+++  LDRE 
Sbjct: 164 TNTVS-------------------FYTLSPNSHFSLNVKTLKDGKPFPELVLEQQLDREA 204

Query: 271 RDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQL 330
           +  ++L L   DGG P RS   ++ V++ D+NDN+P F+ SV    + EN+  GT +L+L
Sbjct: 205 QARHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPIGTLLLRL 264

Query: 331 RAADLDVGVNGQIEYVFGAAT-ESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARD 389
            A D D G NGQ++Y FG  T E+VR L  LD +SG + VL  ID EE         ARD
Sbjct: 265 NATDPDEGTNGQLDYSFGDHTSEAVRNLFGLDPSSGAIHVLGPIDFEESRFYEIHARARD 324

Query: 390 RGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSD 449
           +GQP       + +++ D NDN P + +  +           V E   V T + L  V D
Sbjct: 325 QGQPAMEGHCVIQVDVGDVNDNAPEVLLASLAN--------PVLESTPVGTVVGLFNVRD 376

Query: 450 RDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVD 509
           RD G NG V+  +  D+PFQ+KP        ++  Y L TS PLD EAT  + + ++A D
Sbjct: 377 RDSGRNGEVSLDISPDLPFQIKP--------SENHYSLLTSQPLDREATSHYIIELLASD 428

Query: 510 SGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAE 569
           +GSPSL  + ++ + + D NDN P F Q +   Y  EN  PG  + TV A+D D+G NA 
Sbjct: 429 AGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNAR 488

Query: 570 IAYSL-DSSVMGIFA-----IDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGST 623
           + YS+  + V G  A     ++P+ G I      D E     +  V  +D G P L  +T
Sbjct: 489 LTYSIVGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPLHANT 548

Query: 624 TVIVQVADKNDNDPKFM------QDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLY 677
           ++ V V D+NDN P  +      +      +  +  P S V  VT +DAD G NA +S  
Sbjct: 549 SLHVFVLDENDNAPAVLHPRPDWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYS 608

Query: 678 IEENN---NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMD 734
           +   +    +F +   TG + +  +   +   T    V   D GDP  S+TATV L + D
Sbjct: 609 LLPQSTAPGLFLVSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLED 668

Query: 735 ENDNAPTVTLPKNISYTLLPPS-SNVRTVVATVLATDS 771
           E+       +PK+  + + PP  S++   +   LAT S
Sbjct: 669 EDPE----EMPKSSDFLIHPPERSDLTLYLIVALATVS 702



 Score =  208 bits (529), Expect = 3e-53
 Identities = 178/649 (27%), Positives = 290/649 (44%), Gaps = 67/649 (10%)

Query: 294 LRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATES 353
           + V I D+NDNSP F     E  ++E++A G       A D DVG N    Y     +  
Sbjct: 119 VEVEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNSHF 178

Query: 354 VRRLLRLDETSGW--LSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDN 411
              +  L +   +  L +  ++DRE   + +  + A D G P ++    + + + D NDN
Sbjct: 179 SLNVKTLKDGKPFPELVLEQQLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDN 238

Query: 412 VPSIE--IRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVV-------TCTV 462
            P+ +  + ++G          + E+  + T +  +  +D D+G NG +       T   
Sbjct: 239 APTFQSSVLRVG----------IPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEA 288

Query: 463 VGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLI 522
           V ++ F L P+S            +H   P+D+E +R + +   A D G P++  +  + 
Sbjct: 289 VRNL-FGLDPSSGA----------IHVLGPIDFEESRFYEIHARARDQGQPAMEGHCVIQ 337

Query: 523 VKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIF 582
           V VGD NDN P    + +     E+   G  V      D DSG+N E+  SLD S    F
Sbjct: 338 VDVGDVNDNAPEVLLASLANPVLESTPVGTVVGLFNVRDRDSGRNGEV--SLDISPDLPF 395

Query: 583 AIDPDSG--DILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFM 640
            I P      +L +  LDRE T  Y  ++ A D G P L    T+ + ++D NDN P+F 
Sbjct: 396 QIKPSENHYSLLTSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDVNDNAPRFN 455

Query: 641 QDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEEN-------NNIFSIENDTGT 693
           Q ++T Y+ EN  P S +  V   D D G NA ++  I  N       ++   +  + G 
Sbjct: 456 QQLYTAYILENRPPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFVYVNPEDGR 515

Query: 694 IYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPK----NIS 749
           I++  +FD E        V   D G PP  A  ++ +FV+DENDNAP V  P+    + +
Sbjct: 516 IFAQRTFDYELLQMLQIVVGVRDSGSPPLHANTSLHVFVLDENDNAPAVLHPRPDWEHSA 575

Query: 750 YTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFK-LFEIDPTSGVVSLVGKLT 808
              LP S+   ++V  V A D+D G NA L+YS++  +    LF +   +G V     L 
Sbjct: 576 PQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSTHTGEVRTARALL 635

Query: 809 QKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQDIAGD 868
           +      ++VV V D+G PS S+T  V + + +                 +P + D    
Sbjct: 636 EDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDPE------------EMPKSSDFLIH 683

Query: 869 PSYEISKQRLSIVIGVVAGIMTVILIILI--VVMARYCRSKNKNGYEAG 915
           P      +R  + + ++  + TV L+ L+    ++  C   N +G   G
Sbjct: 684 P-----PERSDLTLYLIVALATVSLLSLVTFTFLSAKCLQGNADGDGGG 727



 Score =  102 bits (253), Expect = 3e-21
 Identities = 79/286 (27%), Positives = 129/286 (45%), Gaps = 28/286 (9%)

Query: 582 FAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTT-------VIVQVADKND 634
           F++   SG + VN  +DRE          A    +  +Q  T        V V++ D ND
Sbjct: 75  FSLSLMSGALAVNQKIDRESL------CGASTSCLLPVQVVTEHPLELIRVEVEILDLND 128

Query: 635 NDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDT--- 691
           N P F        + E+    +   + +  D D G N  +S Y    N+ FS+   T   
Sbjct: 129 NSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNT-VSFYTLSPNSHFSLNVKTLKD 187

Query: 692 ----GTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKN 747
                 +      DRE Q  +   + AVDGG P RS T  +S+ V+D NDNAPT     +
Sbjct: 188 GKPFPELVLEQQLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPT--FQSS 245

Query: 748 ISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFK----LFEIDPTSGVVSL 803
           +    +P ++ + T++  + ATD D+G N  L+YS  G +  +    LF +DP+SG + +
Sbjct: 246 VLRVGIPENAPIGTLLLRLNATDPDEGTNGQLDYSF-GDHTSEAVRNLFGLDPSSGAIHV 304

Query: 804 VGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAI 849
           +G +  +    + +  +  D GQP+     ++ V V +   NA  +
Sbjct: 305 LGPIDFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEV 350



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 56/221 (25%), Positives = 91/221 (41%), Gaps = 16/221 (7%)

Query: 646 FYVKENLQPNSPVGMVTV---MDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDR 702
           + V E  +P + VG V     +      +  + L  EEN   FS+   +G +      DR
Sbjct: 33  YSVVEESEPGTLVGNVAQDLGLKMTDLLSRRLQLGSEENGRYFSLSLMSGALAVNQKIDR 92

Query: 703 EH----QTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSN 758
           E      T+    V+ V   + P      V + ++D NDN+P+   P+         +S 
Sbjct: 93  ESLCGASTSCLLPVQVVT--EHPLE-LIRVEVEILDLNDNSPSFATPEREMRISESAASG 149

Query: 759 VRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSG----VVSLVGKLTQKHYGL 814
            R  + +  A D D G N    Y++   + F L       G     + L  +L ++    
Sbjct: 150 ARFPLDS--AQDPDVGTNTVSFYTLSPNSHFSLNVKTLKDGKPFPELVLEQQLDREAQAR 207

Query: 815 HRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIAR 855
           H+LV+   D G P++S TTL+ V V +   NA    S + R
Sbjct: 208 HQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLR 248


>gi|11128029 protocadherin gamma subfamily B, 6 isoform 1 precursor
           [Homo sapiens]
          Length = 930

 Score =  321 bits (823), Expect = 2e-87
 Identities = 229/738 (31%), Positives = 343/738 (46%), Gaps = 109/738 (14%)

Query: 19  LLLPLSLSL--AAAKQLLRYRLAEEGPADVRIGNVASDLGI-VTGSGEVTFSLESGSEYL 75
           +L PL L L      + +RY + EE      +GN+A DLG+ V         + +   + 
Sbjct: 16  VLFPLLLPLFYPTLSEPIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARKLRVSAEKLHF 75

Query: 76  KIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLD 135
            +D  +G+L   + RIDRE++  C+   +   C L  E  V  P    +++F   V++ D
Sbjct: 76  SVDAESGDLLV-KNRIDREQI--CK---ERRRCELQLEAVVENP----LNIFHVIVVIED 125

Query: 136 INDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGES 195
           +ND+ P F    + L + E+   GT   L  ATD D   N I+ Y++             
Sbjct: 126 VNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKI------------- 172

Query: 196 RRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGE 255
                 +S PY                                     F L V    DG 
Sbjct: 173 ------NSNPY-------------------------------------FSLMVRVNSDGG 189

Query: 256 KQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEA 315
           K P+L ++  LDRE++ S+ L L   DGGDPPRS+ A + + + D NDN P F +  Y  
Sbjct: 190 KYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRI 249

Query: 316 DLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDR 375
            L+EN  PG+P+LQ+ A D D GVN +I Y F +  +S + +  LDE +G +      D 
Sbjct: 250 SLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKNNQSFDF 309

Query: 376 EEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAED 435
           E+V +    V A+D G    + +  V++ I DENDN P I I             ++++ 
Sbjct: 310 EDVERYTMEVEAKDGG--GLSTQCKVIIEILDENDNSPEIII------------TSLSDQ 355

Query: 436 VLVDTP----IALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTST 491
           +L ++P    +AL +  D D G NG V C +  D+PF++  +S+         Y L T  
Sbjct: 356 ILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSN-------NYYKLVTDG 408

Query: 492 PLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPG 551
            LD E T E+NV IVA D G P LSS+ S+ + V D NDN P+F Q+   V+  ENN PG
Sbjct: 409 ALDREQTPEYNVTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPG 468

Query: 552 ERVATVLATDADSGKNAEIAYSLDSS------VMGIFAIDPDSGDILVNTVLDREQTDRY 605
             +A V A+D D G N  I+YS+ +S      V    ++   SG +      D EQ   +
Sbjct: 469 ASIAQVSASDPDLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAF 528

Query: 606 EFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQ-------DVFTFYVKENLQPNSPV 658
              + A+D G P L  + ++ V V D+NDN P+ +          F   V  + +P   V
Sbjct: 529 ALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLV 588

Query: 659 GMVTVMDADKGRNAEMSLYIEENN--NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVD 716
             V  +DAD G NA +S ++ + +   +FS+   TG + +  +            V   D
Sbjct: 589 TKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRD 648

Query: 717 GGDPPRSATATVSLFVMD 734
           GG PP SATAT+ L   D
Sbjct: 649 GGQPPLSATATLHLVFAD 666



 Score =  228 bits (581), Expect = 2e-59
 Identities = 171/660 (25%), Positives = 310/660 (46%), Gaps = 54/660 (8%)

Query: 260 LIVKGALDREQ--RDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317
           L+VK  +DREQ  ++     L++    + P +   ++ V+I DVND++P+F+K     ++
Sbjct: 84  LLVKNRIDREQICKERRRCELQLEAVVENPLNIFHVI-VVIEDVNDHAPQFDKKEIHLEI 142

Query: 318 AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGW---LSVLHRID 374
            E+++ GT +    A D D+ +N   +Y   +       ++R++   G    LS+   +D
Sbjct: 143 FESASAGTRLSLDPATDPDININSIKDYKINS-NPYFSLMVRVNSDGGKYPELSLEKLLD 201

Query: 375 REEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAE 434
           REE       + A D G PP++  A + +++KD NDN P +  R   RI L       +E
Sbjct: 202 REEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDN-PPVFSRDEYRISL-------SE 253

Query: 435 DVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEG--DQNKKKYFLHTSTP 492
           ++   +P+  V  +D+D+G N  +         +    A  T+     ++K   +  +  
Sbjct: 254 NLPPGSPVLQVTATDQDEGVNAEINY-------YFRSTAQSTKHMFSLDEKTGMIKNNQS 306

Query: 493 LDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGE 552
            D+E    + + + A D G   LS+   +I+++ D NDN P    + +     EN+ PG 
Sbjct: 307 FDFEDVERYTMEVEAKDGGG--LSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPGM 364

Query: 553 RVATVLATDADSGKNAEIAYSLDSSV-MGIFAIDPDSGDILVNTVLDREQTDRYEFKVNA 611
            VA     D D G N E+  ++++ +   I++   +   ++ +  LDREQT  Y   + A
Sbjct: 365 VVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVA 424

Query: 612 KDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRN 671
            D+G P L  S ++ + VAD NDN P F Q  +  +V EN  P + +  V+  D D G N
Sbjct: 425 TDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLN 484

Query: 672 AEMSLYIEENN-------NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSA 724
             +S  I  ++       +  S+   +G +++  +FD E    +   ++A D G P  SA
Sbjct: 485 GHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSA 544

Query: 725 TATVSLFVMDENDNAPTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGINADL 779
             ++ + V D NDNAP V  P      +  + ++P S+    +V  V+A D+D G NA L
Sbjct: 545 NVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNAWL 604

Query: 780 NYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFV 839
           +Y ++  +   LF +   +G V     L  +     RL+V V D GQP  S T  +H+  
Sbjct: 605 SYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVF 664

Query: 840 NESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVV 899
            +++                 +  D++  P     +  L   + V   +++V+ ++ +++
Sbjct: 665 ADNLQE---------------ILPDLSDRPVLSDPQAELQFYLVVALALISVLFLLAVIL 709



 Score =  192 bits (489), Expect = 1e-48
 Identities = 146/503 (29%), Positives = 230/503 (45%), Gaps = 30/503 (5%)

Query: 360 LDETSGWLSVLHRIDREEV-NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIR 418
           +D  SG L V +RIDRE++  + R   +  +       +   V++ I+D ND+ P  + +
Sbjct: 77  VDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFDKK 136

Query: 419 KIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEG 478
           +I           + E     T ++L   +D D   N +    +  +  F L    +++G
Sbjct: 137 EIH--------LEIFESASAGTRLSLDPATDPDININSIKDYKINSNPYFSLMVRVNSDG 188

Query: 479 DQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQS 538
            +  +   L     LD E  R  ++++ A+D G P  S+   + + V DTNDNPP+F + 
Sbjct: 189 GKYPE---LSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRD 245

Query: 539 VVEVYFPENNIPGERVATVLATDADSGKNAEIAY---SLDSSVMGIFAIDPDSGDILVNT 595
              +   EN  PG  V  V ATD D G NAEI Y   S   S   +F++D  +G I  N 
Sbjct: 246 EYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKNNQ 305

Query: 596 VLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPN 655
             D E  +RY  +V AKD G   L     VI+++ D+NDN P+ +    +  + EN  P 
Sbjct: 306 SFDFEDVERYTMEVEAKDGG--GLSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPG 363

Query: 656 SPVGMVTVMDADKGRNAEMSLYIEEN--NNIFSIENDTGTIYSTMSFDREHQTTYTFRVK 713
             V +    D D G N E+   IE +    I+S  N+   + +  + DRE    Y   + 
Sbjct: 364 MVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIV 423

Query: 714 AVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTL--LPPSSNVRTVVATVLATDS 771
           A D G PP S++ +++L+V D NDNAP       + +     PP ++    +A V A+D 
Sbjct: 424 ATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGAS----IAQVSASDP 479

Query: 772 DDGINADLNYSIVGGNPFKL-----FEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQ 826
           D G+N  ++YSIV  +   L       +   SGVV        +      L +Q  D G 
Sbjct: 480 DLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGS 539

Query: 827 PSQSTTTLVHVFVNESVSNATAI 849
           P+ S    + V V +   NA  +
Sbjct: 540 PTLSANVSLRVLVGDRNDNAPRV 562



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 80/277 (28%), Positives = 131/277 (47%), Gaps = 35/277 (12%)

Query: 582 FAIDPDSGDILVNTVLDREQT----DRYEFKVNAK-DKGIPVLQGSTTVIVQVADKNDND 636
           F++D +SGD+LV   +DREQ      R E ++ A  +  + +      VIV + D ND+ 
Sbjct: 75  FSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNIFH----VIVVIEDVNDHA 130

Query: 637 PKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIE---NDTGT 693
           P+F +      + E+    + + +    D D   N+ +  Y   +N  FS+    N  G 
Sbjct: 131 PQFDKKEIHLEIFESASAGTRLSLDPATDPDININS-IKDYKINSNPYFSLMVRVNSDGG 189

Query: 694 IYSTMSF----DREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-------V 742
            Y  +S     DRE Q +++  + A+DGGDPPRSATA + + V D NDN P        +
Sbjct: 190 KYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRI 249

Query: 743 TLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSI--VGGNPFKLFEIDPTSGV 800
           +L +N     LPP S     V  V ATD D+G+NA++NY       +   +F +D  +G+
Sbjct: 250 SLSEN-----LPPGS----PVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGM 300

Query: 801 VSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 837
           +        +    + + V+  D G  S     ++ +
Sbjct: 301 IKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEI 337


>gi|14270502 protocadherin gamma subfamily B, 6 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  321 bits (823), Expect = 2e-87
 Identities = 229/738 (31%), Positives = 343/738 (46%), Gaps = 109/738 (14%)

Query: 19  LLLPLSLSL--AAAKQLLRYRLAEEGPADVRIGNVASDLGI-VTGSGEVTFSLESGSEYL 75
           +L PL L L      + +RY + EE      +GN+A DLG+ V         + +   + 
Sbjct: 16  VLFPLLLPLFYPTLSEPIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARKLRVSAEKLHF 75

Query: 76  KIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLD 135
            +D  +G+L   + RIDRE++  C+   +   C L  E  V  P    +++F   V++ D
Sbjct: 76  SVDAESGDLLV-KNRIDREQI--CK---ERRRCELQLEAVVENP----LNIFHVIVVIED 125

Query: 136 INDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGES 195
           +ND+ P F    + L + E+   GT   L  ATD D   N I+ Y++             
Sbjct: 126 VNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKI------------- 172

Query: 196 RRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGE 255
                 +S PY                                     F L V    DG 
Sbjct: 173 ------NSNPY-------------------------------------FSLMVRVNSDGG 189

Query: 256 KQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEA 315
           K P+L ++  LDRE++ S+ L L   DGGDPPRS+ A + + + D NDN P F +  Y  
Sbjct: 190 KYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRI 249

Query: 316 DLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDR 375
            L+EN  PG+P+LQ+ A D D GVN +I Y F +  +S + +  LDE +G +      D 
Sbjct: 250 SLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKNNQSFDF 309

Query: 376 EEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAED 435
           E+V +    V A+D G    + +  V++ I DENDN P I I             ++++ 
Sbjct: 310 EDVERYTMEVEAKDGG--GLSTQCKVIIEILDENDNSPEIII------------TSLSDQ 355

Query: 436 VLVDTP----IALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTST 491
           +L ++P    +AL +  D D G NG V C +  D+PF++  +S+         Y L T  
Sbjct: 356 ILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSN-------NYYKLVTDG 408

Query: 492 PLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPG 551
            LD E T E+NV IVA D G P LSS+ S+ + V D NDN P+F Q+   V+  ENN PG
Sbjct: 409 ALDREQTPEYNVTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPG 468

Query: 552 ERVATVLATDADSGKNAEIAYSLDSS------VMGIFAIDPDSGDILVNTVLDREQTDRY 605
             +A V A+D D G N  I+YS+ +S      V    ++   SG +      D EQ   +
Sbjct: 469 ASIAQVSASDPDLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAF 528

Query: 606 EFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQ-------DVFTFYVKENLQPNSPV 658
              + A+D G P L  + ++ V V D+NDN P+ +          F   V  + +P   V
Sbjct: 529 ALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLV 588

Query: 659 GMVTVMDADKGRNAEMSLYIEENN--NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVD 716
             V  +DAD G NA +S ++ + +   +FS+   TG + +  +            V   D
Sbjct: 589 TKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRD 648

Query: 717 GGDPPRSATATVSLFVMD 734
           GG PP SATAT+ L   D
Sbjct: 649 GGQPPLSATATLHLVFAD 666



 Score =  228 bits (581), Expect = 2e-59
 Identities = 171/660 (25%), Positives = 310/660 (46%), Gaps = 54/660 (8%)

Query: 260 LIVKGALDREQ--RDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317
           L+VK  +DREQ  ++     L++    + P +   ++ V+I DVND++P+F+K     ++
Sbjct: 84  LLVKNRIDREQICKERRRCELQLEAVVENPLNIFHVI-VVIEDVNDHAPQFDKKEIHLEI 142

Query: 318 AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGW---LSVLHRID 374
            E+++ GT +    A D D+ +N   +Y   +       ++R++   G    LS+   +D
Sbjct: 143 FESASAGTRLSLDPATDPDININSIKDYKINS-NPYFSLMVRVNSDGGKYPELSLEKLLD 201

Query: 375 REEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAE 434
           REE       + A D G PP++  A + +++KD NDN P +  R   RI L       +E
Sbjct: 202 REEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDN-PPVFSRDEYRISL-------SE 253

Query: 435 DVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEG--DQNKKKYFLHTSTP 492
           ++   +P+  V  +D+D+G N  +         +    A  T+     ++K   +  +  
Sbjct: 254 NLPPGSPVLQVTATDQDEGVNAEINY-------YFRSTAQSTKHMFSLDEKTGMIKNNQS 306

Query: 493 LDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGE 552
            D+E    + + + A D G   LS+   +I+++ D NDN P    + +     EN+ PG 
Sbjct: 307 FDFEDVERYTMEVEAKDGGG--LSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPGM 364

Query: 553 RVATVLATDADSGKNAEIAYSLDSSV-MGIFAIDPDSGDILVNTVLDREQTDRYEFKVNA 611
            VA     D D G N E+  ++++ +   I++   +   ++ +  LDREQT  Y   + A
Sbjct: 365 VVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVA 424

Query: 612 KDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRN 671
            D+G P L  S ++ + VAD NDN P F Q  +  +V EN  P + +  V+  D D G N
Sbjct: 425 TDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLN 484

Query: 672 AEMSLYIEENN-------NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSA 724
             +S  I  ++       +  S+   +G +++  +FD E    +   ++A D G P  SA
Sbjct: 485 GHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSA 544

Query: 725 TATVSLFVMDENDNAPTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGINADL 779
             ++ + V D NDNAP V  P      +  + ++P S+    +V  V+A D+D G NA L
Sbjct: 545 NVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNAWL 604

Query: 780 NYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFV 839
           +Y ++  +   LF +   +G V     L  +     RL+V V D GQP  S T  +H+  
Sbjct: 605 SYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVF 664

Query: 840 NESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVV 899
            +++                 +  D++  P     +  L   + V   +++V+ ++ +++
Sbjct: 665 ADNLQE---------------ILPDLSDRPVLSDPQAELQFYLVVALALISVLFLLAVIL 709



 Score =  192 bits (489), Expect = 1e-48
 Identities = 146/503 (29%), Positives = 230/503 (45%), Gaps = 30/503 (5%)

Query: 360 LDETSGWLSVLHRIDREEV-NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIR 418
           +D  SG L V +RIDRE++  + R   +  +       +   V++ I+D ND+ P  + +
Sbjct: 77  VDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFDKK 136

Query: 419 KIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEG 478
           +I           + E     T ++L   +D D   N +    +  +  F L    +++G
Sbjct: 137 EIH--------LEIFESASAGTRLSLDPATDPDININSIKDYKINSNPYFSLMVRVNSDG 188

Query: 479 DQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQS 538
            +  +   L     LD E  R  ++++ A+D G P  S+   + + V DTNDNPP+F + 
Sbjct: 189 GKYPE---LSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRD 245

Query: 539 VVEVYFPENNIPGERVATVLATDADSGKNAEIAY---SLDSSVMGIFAIDPDSGDILVNT 595
              +   EN  PG  V  V ATD D G NAEI Y   S   S   +F++D  +G I  N 
Sbjct: 246 EYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKNNQ 305

Query: 596 VLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPN 655
             D E  +RY  +V AKD G   L     VI+++ D+NDN P+ +    +  + EN  P 
Sbjct: 306 SFDFEDVERYTMEVEAKDGG--GLSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPG 363

Query: 656 SPVGMVTVMDADKGRNAEMSLYIEEN--NNIFSIENDTGTIYSTMSFDREHQTTYTFRVK 713
             V +    D D G N E+   IE +    I+S  N+   + +  + DRE    Y   + 
Sbjct: 364 MVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIV 423

Query: 714 AVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTL--LPPSSNVRTVVATVLATDS 771
           A D G PP S++ +++L+V D NDNAP       + +     PP ++    +A V A+D 
Sbjct: 424 ATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGAS----IAQVSASDP 479

Query: 772 DDGINADLNYSIVGGNPFKL-----FEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQ 826
           D G+N  ++YSIV  +   L       +   SGVV        +      L +Q  D G 
Sbjct: 480 DLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGS 539

Query: 827 PSQSTTTLVHVFVNESVSNATAI 849
           P+ S    + V V +   NA  +
Sbjct: 540 PTLSANVSLRVLVGDRNDNAPRV 562



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 80/277 (28%), Positives = 131/277 (47%), Gaps = 35/277 (12%)

Query: 582 FAIDPDSGDILVNTVLDREQT----DRYEFKVNAK-DKGIPVLQGSTTVIVQVADKNDND 636
           F++D +SGD+LV   +DREQ      R E ++ A  +  + +      VIV + D ND+ 
Sbjct: 75  FSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNIFH----VIVVIEDVNDHA 130

Query: 637 PKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIE---NDTGT 693
           P+F +      + E+    + + +    D D   N+ +  Y   +N  FS+    N  G 
Sbjct: 131 PQFDKKEIHLEIFESASAGTRLSLDPATDPDININS-IKDYKINSNPYFSLMVRVNSDGG 189

Query: 694 IYSTMSF----DREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-------V 742
            Y  +S     DRE Q +++  + A+DGGDPPRSATA + + V D NDN P        +
Sbjct: 190 KYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRI 249

Query: 743 TLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSI--VGGNPFKLFEIDPTSGV 800
           +L +N     LPP S     V  V ATD D+G+NA++NY       +   +F +D  +G+
Sbjct: 250 SLSEN-----LPPGS----PVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGM 300

Query: 801 VSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 837
           +        +    + + V+  D G  S     ++ +
Sbjct: 301 IKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEI 337


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score =  320 bits (819), Expect = 6e-87
 Identities = 248/805 (30%), Positives = 371/805 (46%), Gaps = 98/805 (12%)

Query: 34  LRYRLAEEGPADVRIGNVASDLGIVTGSGEVTF-SLESGSEY---LKIDNLTGELSTSER 89
           L  ++ EE PA   IG++++ L   T +  + F S + GS     L ID  +G + T+ R
Sbjct: 47  LDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTA-R 105

Query: 90  RIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLT 149
            +DRE+  +             +  + + P  + V++    V V DIND+ P FP     
Sbjct: 106 VLDREQRDR-------------YRFTAVTPDGATVEV---TVRVADINDHAPAFPQARAA 149

Query: 150 LTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGG 209
           L V E+   GT Y L  A D D GR G + Y L                           
Sbjct: 150 LQVPEHTAFGTRYPLEPARDADAGRLGTQGYAL--------------------------- 182

Query: 210 GGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDRE 269
                SG G+G                       F L+    PDG   P+L+V G LDRE
Sbjct: 183 -----SGDGAG---------------------ETFRLETRPGPDGTPVPELVVTGELDRE 216

Query: 270 QRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQ 329
            R  Y L L   DGG PPR +QA+L V + D+ND++P F +S Y A ++E+ APG+P+LQ
Sbjct: 217 NRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQ 276

Query: 330 LRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARD 389
           + A+D D GVNG + Y              +D  +G L +   +D E+       V ARD
Sbjct: 277 VFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARD 336

Query: 390 RGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSD 449
            G  P+   A V ++++D NDN PS+ +  +      DG   V+E       +A + VSD
Sbjct: 337 GGAHPELGSAFVTVHVRDANDNQPSMTVIFLS----ADGSPQVSEAAPPGQLVARISVSD 392

Query: 450 RDQGENGVVTCTVV-GDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAV 508
            D G+   V  ++  G+  F L         Q+   Y +  +  LD E    +N+ + A 
Sbjct: 393 PDDGDFAHVNVSLEGGEGHFAL-------STQDSVIYLVCVARRLDREERDAYNLRVTAT 445

Query: 509 DSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVY-FPENNIPGERVATVLATDADSGKN 567
           DSGSP L +  + ++ V D NDN P F + +      PE  +PG  V  V A D D G N
Sbjct: 446 DSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTN 505

Query: 568 AEIAYSL-DSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVI 626
            ++ YSL   +    F+IDP SG I     LD E   + +  V A D G+P L  S TV 
Sbjct: 506 GQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVS 565

Query: 627 VQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYI-----EEN 681
           V + D NDN+P+F +  +   + E  QP +    VT  DAD G    +S  +        
Sbjct: 566 VALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSG 625

Query: 682 NNIFSIENDTGTIYSTMSFDREH-QTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAP 740
           +  F I+  +G + +T + DR+   +++ F V AVDGG     +   V +F+ DENDN P
Sbjct: 626 SPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPP 683

Query: 741 TVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGV 800
               P+  + + +   S   T V  + A D D G +  L+Y I+ GN   LF +D  SG+
Sbjct: 684 QF-YPREYAAS-ISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGL 741

Query: 801 VSLVGKLTQKHYGLHRLVVQVNDSG 825
           +++   L ++   + +L +   D G
Sbjct: 742 LTVAWPLARRANSVVQLEIGAEDGG 766



 Score =  250 bits (639), Expect = 4e-66
 Identities = 252/870 (28%), Positives = 374/870 (42%), Gaps = 138/870 (15%)

Query: 41   EGPADVRIGNVASDLGI----VTGSGEVTFSLESGSE-YLKIDNLTGELSTSERRIDREK 95
            E P DV  G +   L         +G VT+ L +G+     ++  +GEL T+   +DRE+
Sbjct: 1863 EVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAA-LDREQ 1921

Query: 96   LPQCQMIFDENECFLDFEVSVI-----GPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTL 150
             P              F VS +     GP  + V +    + V D+ND+ PTFP+  L L
Sbjct: 1922 CPS-----------YTFSVSAVDGAAAGPLSTTVSV---TITVRDVNDHAPTFPTSPLRL 1967

Query: 151  TVEENRPVGTLYLLPTAT----DRDFGRNGIERYELLQEPGGGGS----GGESRRA---- 198
             +    P  +   L  AT    DRD G N    Y L   P  G +     GE R A    
Sbjct: 1968 RLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPV 2027

Query: 199  --GAADSAPYP-----GGGGNGASG----GGSGGSKR-------------RLDASEG--- 231
              G  D   +      G     A+G    G  G ++R             R +A  G   
Sbjct: 2028 ALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI 2087

Query: 232  -------GGGTN--------PGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYEL 276
                    GGTN         G     F +Q +      +  +      LD E      L
Sbjct: 2088 VSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAE-----GLDFEVSPRLRL 2142

Query: 277  TLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLD 336
             L+   GG     +  +L + + D NDN+PRF +  Y A L E+     P+LQ+ A DLD
Sbjct: 2143 VLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLD 2199

Query: 337  VGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKT 396
             G  GQI Y   AA++  R L  +D T+G ++    +DRE   + R  +MA DRG P   
Sbjct: 2200 QGSGGQISYSL-AASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALV 2258

Query: 397  DKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENG 456
              AT+ + + D NDN P+I          +     V+ED L+ + IA V  +D D G   
Sbjct: 2259 GSATLTVMVIDTNDNRPTIP---------QPWELRVSEDALLGSEIAQVTGNDVDSGP-- 2307

Query: 457  VVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTST--PLDYEATREFNVVIVAVDSGSPS 514
                     V + +   S  +   +  +Y    S   PLD+E    + + ++A D     
Sbjct: 2308 ---------VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEG 2358

Query: 515  LSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSL 574
             ++   L V V D NDN P F QS+ +V   E+  PG  + +V ATD DSG N  I+Y L
Sbjct: 2359 RAN---LTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL 2415

Query: 575  DSSVMGIFAIDPDSGDI--LVNTV-LDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVAD 631
             S   G F++DP++G +  +V TV L  + +   +  + A+D G P      TV VQ+ D
Sbjct: 2416 ASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQD 2474

Query: 632  KNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRN---AEMSLYIEENNNIFSIE 688
            +ND+ P F    +   V E+L P S +  +   DAD  R+    + S+       +F +E
Sbjct: 2475 QNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLE 2534

Query: 689  --------------NDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMD 734
                             G +      D E  T Y   V A D G PP+S+   V++ V+D
Sbjct: 2535 PRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLD 2594

Query: 735  ENDNAPTVTLPKNISYTL-LPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFE 793
             NDN P  T     SY + +P  + V   +  V A+D+D G +  + +++  G+P  LFE
Sbjct: 2595 VNDNPPVFT---RASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFE 2651

Query: 794  IDPTSGVVSLVGKLTQKHYGLHRLVVQVND 823
            +D +SG + L   L  +    H+LVVQ  D
Sbjct: 2652 LDESSGTLRLAHALDCETQARHQLVVQAAD 2681



 Score =  242 bits (618), Expect = 1e-63
 Identities = 214/741 (28%), Positives = 313/741 (42%), Gaps = 112/741 (15%)

Query: 75   LKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVL 134
            L++D  TG LS + R +DRE  P   ++ +  +            S+        +V V 
Sbjct: 1486 LRLDARTGALS-APRGLDRETTPALLLLVEATD-------RPANASRRRAARVSARVFVT 1537

Query: 135  DINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGE 194
            D NDN P F SP   + + E++P G   L   A D D G      Y L            
Sbjct: 1538 DENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRL------------ 1584

Query: 195  SRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDG 254
                                + GG G    RL +S G                       
Sbjct: 1585 --------------------ASGGDGHF--RLHSSTGA---------------------- 1600

Query: 255  EKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYE 314
                 L V   LDREQR  + LT+   D G PPRS+  +L V + DVND +P F++  Y 
Sbjct: 1601 -----LSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYS 1655

Query: 315  ADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRID 374
              L EN+ PGT +L LRA D DVG NGQ+ Y  G ++ES      LD  +G L+ L  +D
Sbjct: 1656 VLLRENNPPGTSLLTLRATDPDVGANGQVTY-GGVSSES----FSLDPDTGVLTTLRALD 1710

Query: 375  REEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAE 434
            REE  ++  TV A+DRG PP+    TV + ++DEND+ P+             G A+++ 
Sbjct: 1711 REEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTF------------GSAHLSL 1758

Query: 435  DV---LVDTPIALVQVSDRDQGENGVVTCTVVGDVP---FQLKPASDTEGDQNKKKYFLH 488
            +V        + +++ SD D G NG +   ++   P   F L  AS   G          
Sbjct: 1759 EVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFG---------- 1808

Query: 489  TSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENN 548
            T  PLD E    F + I A D G P+LS+   L V V D ND+ P F      V  PE+ 
Sbjct: 1809 TMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDV 1868

Query: 549  IPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFK 608
              G  +  + A D D+G N  + Y L +   G F ++P SG++     LDREQ   Y F 
Sbjct: 1869 PAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFS 1928

Query: 609  VNAKD-KGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKEN----LQPNSPVGMVTV 663
            V+A D      L  + +V + V D ND+ P F        +         P   +  +  
Sbjct: 1929 VSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRA 1988

Query: 664  MDADKGRNAEMSLYIEENNNI-FSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPR 722
             D D G NA +   +        ++++ TG I    S            + A D G P R
Sbjct: 1989 EDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPAR 2048

Query: 723  SATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYS 782
            SAT  + + +  E +  P    P+  S   +  ++   T + +  A  +  G N  + YS
Sbjct: 2049 SATGVIIVGLQGEAERGP--RFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITYS 2105

Query: 783  IVGGNPFKLFEIDPTSGVVSL 803
            I+ GN    F I P++G +++
Sbjct: 2106 ILSGNEKGTFSIQPSTGAITV 2126



 Score =  228 bits (582), Expect = 2e-59
 Identities = 217/795 (27%), Positives = 328/795 (41%), Gaps = 100/795 (12%)

Query: 61   SGEVTFSLESGSE--YLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIG 118
            +G+VT+SL  G+   +  ID  +G ++T+   +D E  PQ Q+I           V+  G
Sbjct: 505  NGQVTYSLAPGAHTHWFSIDPTSGIITTAAS-LDYELEPQPQLIV----------VATDG 553

Query: 119  PSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIE 178
                        V + D+NDN P F       ++ E    GT +L  TATD D G  G+ 
Sbjct: 554  GLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLL 613

Query: 179  RYELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPG 238
             Y L                              GA  G SG    R+DA  G       
Sbjct: 614  SYSL------------------------------GAGLGSSGSPPFRIDAHSG------- 636

Query: 239  GRSSVFELQVADTPDGEKQPQLIVKGALDREQR-DSYELTLRVRDGGDPPRSSQAILRVL 297
                                 +     LDR+Q   S++ T+   DGG     S   ++V 
Sbjct: 637  --------------------DVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVF 674

Query: 298  ITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRL 357
            ++D NDN P+F    Y A ++  S PGT +L+LRA D D G +G++ Y   A       L
Sbjct: 675  LSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPP--L 732

Query: 358  LRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEI 417
              LDE SG L+V   + R   + ++  + A D G       A V ++I       P  E 
Sbjct: 733  FTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQ 792

Query: 418  RKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTE 477
             +         V +V EDV   T + +VQ  +   G    VT ++ G  P  L       
Sbjct: 793  LQY--------VFSVPEDVAPGTSVGIVQAHN-PPGRLAPVTLSLSGGDPRGLFSLDAVS 843

Query: 478  GDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQ 537
            G        L T  PLD E       + V   SG P   +   + V + D NDN P F  
Sbjct: 844  G-------LLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPA 896

Query: 538  SVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVL 597
                V  P N  PG  + T+ A D DSG N+ + ++L +   G F +DP +G + +   L
Sbjct: 897  PEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPL 956

Query: 598  DREQTDRYEFKVNAKDKGIP--VLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPN 655
                   +E ++ A+D G P         V+VQ        P+F    +   +       
Sbjct: 957  GPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAG 1016

Query: 656  SPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAV 715
            + V  V     D G      L  E  ++ F +E  +G ++   + DRE Q  Y  +V AV
Sbjct: 1017 TQVLQVQAQAPD-GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAV 1075

Query: 716  DGGDP---PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSD 772
             G       ++ TATV + ++++N+++P   L ++ ++  +  +    T V  V ATD D
Sbjct: 1076 SGSKAELGQQTGTATVRVSILNQNEHSP--RLSEDPTFLAVAENQPPGTSVGRVFATDRD 1133

Query: 773  DGINADLNYSIVG-GNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQST 831
             G N  L YS+       K F I P +G V+ +  L ++    ++L+VQV D G P +ST
Sbjct: 1134 SGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193

Query: 832  TTLVHVFVNESVSNA 846
            T  VHV V +   N+
Sbjct: 1194 TGTVHVAVLDLNDNS 1208



 Score =  226 bits (576), Expect = 9e-59
 Identities = 237/859 (27%), Positives = 362/859 (42%), Gaps = 122/859 (14%)

Query: 58   VTGSGEVTFSLESG--SEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVS 115
            V  +G++ + +  G  S    +D  +GE  T  R +DRE  P  Q+  +  +        
Sbjct: 1779 VGANGQLQYRILDGDPSGAFVLDLASGEFGTM-RPLDREVEPAFQLRIEARD-------- 1829

Query: 116  VIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRN 175
              G   +        V VLD ND+ P FP P  ++ V E+ P GTL L   A D D G N
Sbjct: 1830 --GGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGAN 1887

Query: 176  GIERYELLQEPGGG----GSGGESRRAGAADSAPYPG-----GGGNGASGGGSGGSKRRL 226
            G   Y L     G      S GE R A A D    P         +GA+ G    +    
Sbjct: 1888 GHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVT 1947

Query: 227  DASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRD-------------- 272
                      P   +S   L++         P L +   L  E RD              
Sbjct: 1948 ITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLAL-ATLRAEDRDAGANASILYRLAGT 2006

Query: 273  --------SYELTLRVR------------------DGGDPPRSSQAILRVLITDVNDNSP 306
                    SY   +RV                   D G P RS+  ++ V +    +  P
Sbjct: 2007 PPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGP 2066

Query: 307  RFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGW 366
            RF ++  EA + EN+ PGTPI+  RA     G NG I Y   +  E  +    +  ++G 
Sbjct: 2067 RFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNE--KGTFSIQPSTGA 2123

Query: 367  LSV--LHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIP 424
            ++V     +D E   +LR  + A   G    T    + L ++D NDN P        R  
Sbjct: 2124 ITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAP--------RFL 2172

Query: 425  LKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVP----FQLKPASDTEGDQ 480
                VA + E   ++ P+  V+  D DQG  G ++ ++    P    F + P + T    
Sbjct: 2173 RPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGT---- 2228

Query: 481  NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV 540
                  + T+  LD E   E  +V++A D GSP+L  + +L V V DTNDN P   Q   
Sbjct: 2229 ------ITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPW- 2281

Query: 541  EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600
            E+   E+ + G  +A V   D DSG       S  S     F++    G + +   LD E
Sbjct: 2282 ELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLS-PSGPQDPFSVGRYGGRVSLTGPLDFE 2340

Query: 601  QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM 660
            Q DRY+ ++ A D      +G   + V V D NDN P F Q ++   + E+  P S +  
Sbjct: 2341 QCDRYQLQLLAHDGPH---EGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILS 2397

Query: 661  VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYS---TMSFDREHQTTYTFRVKAVDG 717
            V+  D D G N  +S ++    + FS++ + GT+++   T++   +        ++A D 
Sbjct: 2398 VSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDH 2457

Query: 718  GDPPRSATATVSLFVMDENDNAPTVTLPK-NISYTL-LPPSSNVRTVVATVLATDSDDG- 774
            G P R+A ATV + + D+ND+AP+ TL    ++ T  LPP S + T+ AT    D+D   
Sbjct: 2458 GAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT----DADGSR 2513

Query: 775  INADLNYSIVGGNPFKLFEIDP--------------TSGVVSLVGKLTQKHYGLHRLVVQ 820
             +A ++YSI+ GN  ++F+++P                G + L+  L  +    + L V 
Sbjct: 2514 SHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVA 2573

Query: 821  VNDSGQPSQSTTTLVHVFV 839
              D GQP QS+   V V V
Sbjct: 2574 AADRGQPPQSSVVPVTVTV 2592



 Score =  218 bits (554), Expect = 3e-56
 Identities = 227/833 (27%), Positives = 343/833 (41%), Gaps = 124/833 (14%)

Query: 35   RYRLAEE---GPADVRIGNVASDLGIVTGSGEVTFSLESGSE-YLKIDNLTGELSTSERR 90
            R RL E+   GPA + +     DLG    +  V++ L SG + + ++ + TG LS   R 
Sbjct: 1551 RVRLPEDQPPGPAALHVVARDPDLG---EAARVSYRLASGGDGHFRLHSSTGALSVV-RP 1606

Query: 91   IDREKLPQCQMIFDENECFLDFEVSVIG-PSQSWVDLFEGQVIVLDINDNTPTFPSPVLT 149
            +DRE+           E  L    S  G P +S   +    V V D+ND  PTF     +
Sbjct: 1607 LDREQ---------RAEHVLTVVASDHGSPPRSATQVLT--VSVADVNDEAPTFQQQEYS 1655

Query: 150  LTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGG 209
            + + EN P GT  L   ATD D G NG   Y                             
Sbjct: 1656 VLLRENNPPGTSLLTLRATDPDVGANGQVTY----------------------------- 1686

Query: 210  GGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDRE 269
                   GG       LD   G              L      D E+Q ++         
Sbjct: 1687 -------GGVSSESFSLDPDTG-------------VLTTLRALDREEQEEI--------- 1717

Query: 270  QRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQ 329
                  LT+  +D G PP+ +   +RV + D ND++P F  +    ++ E   P T +  
Sbjct: 1718 -----NLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT-LTM 1771

Query: 330  LRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARD 389
            LRA+D DVG NGQ++Y       S      LD  SG    +  +DRE     +  + ARD
Sbjct: 1772 LRASDPDVGANGQLQYRILDGDPS--GAFVLDLASGEFGTMRPLDREVEPAFQLRIEARD 1829

Query: 390  RGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSD 449
             GQP  +    + + + D ND+ P+         P+      V EDV   T +  +Q  D
Sbjct: 1830 GGQPALSATLLLTVTVLDANDHAPA--------FPVPAYSVEVPEDVPAGTLLLQLQAHD 1881

Query: 450  RDQGENGVVTCTVVGDV--PFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVA 507
             D G NG VT  +       F L+P+S            L T+  LD E    +   + A
Sbjct: 1882 PDAGANGHVTYYLGAGTAGAFLLEPSSGE----------LRTAAALDREQCPSYTFSVSA 1931

Query: 508  VDSGSPS-LSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPEN----NIPGERVATVLATDA 562
            VD  +   LS+  S+ + V D ND+ P F  S + +  P      + P   +AT+ A D 
Sbjct: 1932 VDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDR 1991

Query: 563  DSGKNAEIAYSLDSSVMGIFAIDPDSGDILV-NTVLDREQTDRYEFKVNAKDKGIPVLQG 621
            D+G NA I Y L  +      +D  +G+I V  + +     DR  F V A D G P    
Sbjct: 1992 DAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIV-ATDLGRPARSA 2050

Query: 622  STTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEEN 681
            +  +IV +  + +  P+F +      ++EN  P +P+     + A  G N  ++  I   
Sbjct: 2051 TGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSG 2109

Query: 682  N--NIFSIENDTG--TIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDEND 737
            N    FSI+  TG  T+ S    D E        ++A  GG     A   ++L + D ND
Sbjct: 2110 NEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGG---AFAFTVLTLTLQDAND 2166

Query: 738  NAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFK-LFEIDP 796
            NAP    P  +++  LP S  +   +  V A D D G    ++YS+    P + LF +DP
Sbjct: 2167 NAPRFLRPHYVAF--LPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDP 2224

Query: 797  TSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAI 849
            T+G ++    L ++ +   RLV+   D G P+   +  + V V ++  N   I
Sbjct: 2225 TTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI 2277



 Score =  216 bits (550), Expect = 9e-56
 Identities = 167/580 (28%), Positives = 274/580 (47%), Gaps = 50/580 (8%)

Query: 251  TPDGEKQP--------QLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVN 302
            +P G + P        ++ + G LD EQ D Y+L L   DG   P   +A L VL+ DVN
Sbjct: 2314 SPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVN 2370

Query: 303  DNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDE 362
            DN+P F +S+Y+  L E++ PG+ IL + A D D G NG I Y   +  +       +D 
Sbjct: 2371 DNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG----FSVDP 2426

Query: 363  TSGWLSVLH---RIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRK 419
             +G L  +     +  +    +   + ARD G P +  +ATV + ++D+ND+ PS  +  
Sbjct: 2427 NNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSH 2486

Query: 420  IGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGEN-GVVTCTVV----GDVPFQLKP-- 472
                        V ED+   + +  ++ +D D   +   V  +++    G V FQL+P  
Sbjct: 2487 YR--------VAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRV-FQLEPRL 2537

Query: 473  --ASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTND 530
              A ++ G   +    L    PLD+E+  ++N+ + A D G P  SS   + V V D ND
Sbjct: 2538 AEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVND 2597

Query: 531  NPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDS-SVMGIFAIDPDSG 589
            NPP+F ++   V  PE+   G  +  V A+DAD G +  + +++ S    G+F +D  SG
Sbjct: 2598 NPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSG 2657

Query: 590  DILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVK 649
             + +   LD E   R++  V A D           V ++V D ND+ P F  ++ +  V 
Sbjct: 2658 TLRLAHALDCETQARHQLVVQAADPA-GAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVA 2716

Query: 650  ENLQPNSPVGMVTVMDADKGRNAEMSLYI------EENNNIFSIENDTGTIYSTMSFDRE 703
            EN  P + V  +  +D D G    +   +       E    F++ + TG + + + FD E
Sbjct: 2717 ENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYE 2776

Query: 704  HQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVV 763
            H  ++   V A D G+   SA+ TVS+ V  E++  P    P    +  +P  +     +
Sbjct: 2777 HTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAP--AFHFQVPEGARRGHSL 2832

Query: 764  ATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSL 803
              V ATD D G +  + YS+   +P+  F I+ T+G + L
Sbjct: 2833 GHVQATDEDGGADGLVLYSLATSSPY--FGINQTTGALYL 2870



 Score =  202 bits (513), Expect = 2e-51
 Identities = 236/849 (27%), Positives = 344/849 (40%), Gaps = 123/849 (14%)

Query: 38   LAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLK---IDNLTGELSTSERRIDRE 94
            +AE  P    +G V +       +G +T+SL+  SE  K   I   TGE++T +  +DRE
Sbjct: 1114 VAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQT-LDRE 1172

Query: 95   KLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTF------PSPVL 148
            +    Q++    +          G S          V VLD+NDN+PTF          L
Sbjct: 1173 QQSSYQLLVQVQD----------GGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGL 1222

Query: 149  TLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPG 208
             + V +  P GTL     A D D G NG   Y L                          
Sbjct: 1223 PIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTL-------------------------- 1256

Query: 209  GGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDR 268
                                      T PG  S +F L       GE    L+    L R
Sbjct: 1257 --------------------------TGPG--SELFSLH---PHSGE----LLTAAPLIR 1281

Query: 269  EQRDSYELTLRVRDGGDPPRSS--QAILRVLIT--------DVNDNSPRFE-KSVYEADL 317
             +R  Y LTL   D G PPRS+  Q +++VL +        D+ +  P      V     
Sbjct: 1282 AERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTA 1341

Query: 318  AENSAPGTPILQLRAADLDVGVNGQIEY--VFGAATESVRRLLRLDETSGWLSVLHRIDR 375
            AE   PG+ +L   AA    GV G + Y  V GA  E       LD  SG L +   +D 
Sbjct: 1342 AEGLRPGS-LLGSVAAPEPAGV-GALTYTLVGGADPEGT---FALDAASGRLYLARPLDF 1396

Query: 376  EEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAED 435
            E     R   +  +           V + ++DEN++ P+       R PL      + E+
Sbjct: 1397 EAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPA-----FARDPL---ALALPEN 1448

Query: 436  VLVDTPIALVQVSDRD-QGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLD 494
                  +   + SD D  G N  V   ++   P    P      D   +   L     LD
Sbjct: 1449 PEPGAALYTFRASDADGPGPNSDVRYRLLRQEP----PVPALRLD--ARTGALSAPRGLD 1502

Query: 495  YEATREFNVVIVAVD---SGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPG 551
             E T    +++ A D   + S   ++  S  V V D NDN P+F  S   V  PE+  PG
Sbjct: 1503 RETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA-SPSRVRLPEDQPPG 1561

Query: 552  ERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNA 611
                 V+A D D G+ A ++Y L S   G F +   +G + V   LDREQ   +   V A
Sbjct: 1562 PAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVA 1621

Query: 612  KDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRN 671
             D G P    +  + V VAD ND  P F Q  ++  ++EN  P + +  +   D D G N
Sbjct: 1622 SDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGAN 1681

Query: 672  AEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLF 731
             +++ Y   ++  FS++ DTG + +  + DRE Q      V A D G PP+    TV + 
Sbjct: 1682 GQVT-YGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVA 1740

Query: 732  VMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKL 791
            V DEND+APT     +   +L  P       +  + A+D D G N  L Y I+ G+P   
Sbjct: 1741 VEDENDHAPTF---GSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGA 1797

Query: 792  FEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDS 851
            F +D  SG    +  L ++     +L ++  D GQP+ S T L+ V V ++  +A A   
Sbjct: 1798 FVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPV 1857

Query: 852  QIARSLHIP 860
              A S+ +P
Sbjct: 1858 P-AYSVEVP 1865



 Score =  188 bits (478), Expect = 2e-47
 Identities = 161/547 (29%), Positives = 225/547 (41%), Gaps = 35/547 (6%)

Query: 314 EADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATES-VRRLLRLDETSGWLSVLHR 372
           +  + E    GT I  + +A L  G    + Y   A   S V   L +DE SG +     
Sbjct: 48  DLQIDEEQPAGTLIGDI-SAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARV 106

Query: 373 IDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANV 432
           +DRE+ ++ RFT +  D           V + + D ND+ P+         P       V
Sbjct: 107 LDREQRDRYRFTAVTPDGAT------VEVTVRVADINDHAPAF--------PQARAALQV 152

Query: 433 AEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTP 492
            E     T   L    D D G  G     + GD   +        G        L  +  
Sbjct: 153 PEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGE 212

Query: 493 LDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGE 552
           LD E    + + + A D GSP   +   L V + D ND+ P F QS       E+  PG 
Sbjct: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272

Query: 553 RVATVLATDADSGKNAEIAYSLD---SSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKV 609
            V  V A+DAD+G N  + Y ++   S   G F+ID  +G + +   LD EQ   +E  V
Sbjct: 273 PVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVV 332

Query: 610 NAKDKGIPVLQGSTTVIVQVADKNDNDPK----FMQDVFTFYVKENLQPNSPVGMVTVMD 665
            A+D G     GS  V V V D NDN P     F+    +  V E   P   V  ++V D
Sbjct: 333 QARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSD 392

Query: 666 ADKGRNAEMSLYIEENNNIFSIENDTGTIYSTM---SFDREHQTTYTFRVKAVDGGDPPR 722
            D G  A +++ +E     F++      IY        DRE +  Y  RV A D G PP 
Sbjct: 393 PDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPL 452

Query: 723 SATATVSLFVMDENDNAPT----VTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINAD 778
            A A   L V D NDNAP     +  P+ +    LP S  VR     V A D D G N  
Sbjct: 453 RAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVR-----VTARDPDQGTNGQ 507

Query: 779 LNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVF 838
           + YS+  G     F IDPTSG+++    L  +     +L+V   D G P  +++  V V 
Sbjct: 508 VTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVA 567

Query: 839 VNESVSN 845
           + +   N
Sbjct: 568 LQDVNDN 574



 Score =  185 bits (470), Expect = 2e-46
 Identities = 210/827 (25%), Positives = 324/827 (39%), Gaps = 141/827 (17%)

Query: 64   VTFSLESGSE--YLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQ 121
            VT SL  G       +D ++G L T  R +DRE L             L+ EV       
Sbjct: 824  VTLSLSGGDPRGLFSLDAVSGLLQTL-RPLDRELLGPV----------LELEVRAGSGVP 872

Query: 122  SWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYE 181
                +   +V++ D+NDN+P FP+P  T+ +  N   GT      A D D G N    + 
Sbjct: 873  PAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFT 932

Query: 182  LLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRS 241
            LL                         GGG   +   + G  R +      GG       
Sbjct: 933  LL------------------------AGGGGAFTVDPTTGHVRLMRPLGPSGGP------ 962

Query: 242  SVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDV 301
                                           ++EL L  RDGG PPR+S   LRV++ DV
Sbjct: 963  -------------------------------AHELELEARDGGSPPRTSHFRLRVVVQDV 991

Query: 302  NDN--SPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLR 359
                 +PRF    Y  DL   +  GT +LQ++A   D G        +  A E       
Sbjct: 992  GTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG-----PITYHLAAEGASSPFG 1046

Query: 360  LDETSGWLSVLHRIDREEVNQLRFTVMA-----RDRGQPPKTDKATVVLNIKDENDNVPS 414
            L+  SGWL V   +DRE        VMA      + GQ  +T  ATV ++I ++N++ P 
Sbjct: 1047 LEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQ--QTGTATVRVSILNQNEHSP- 1103

Query: 415  IEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPAS 474
                   R+        VAE+    T +  V  +DRD G NG +T        + L+  S
Sbjct: 1104 -------RLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLT--------YSLQQLS 1148

Query: 475  DTEGDQNKKKYFLHTST-------PLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGD 527
            +     + K + +H  T        LD E    + +++   D GSP  S+  ++ V V D
Sbjct: 1149 E-----DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLD 1203

Query: 528  TNDNPPMFGQSV------VEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGI 581
             NDN P F Q+       + +  P+   PG  V T+ A D D G+N  I Y+L      +
Sbjct: 1204 LNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSEL 1263

Query: 582  FAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQV----------AD 631
            F++ P SG++L    L R +   Y   ++A D+G P    S  ++VQV           D
Sbjct: 1264 FSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPD 1323

Query: 632  KNDNDPKF-MQDVFTFYVKENLQPNSPVGMVTVMD-ADKGRNAEMSLYIEENNNIFSIEN 689
              + DP   +  V T    E L+P S +G V   + A  G      +   +    F+++ 
Sbjct: 1324 LAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDA 1383

Query: 690  DTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNIS 749
             +G +Y     D E    +       +G     +    V + V DEN++AP     ++  
Sbjct: 1384 ASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAP--AFARDPL 1441

Query: 750  YTLLPPSSNVRTVVATVLATDSD-DGINADLNYSIVGGN-PFKLFEIDPTSGVVSLVGKL 807
               LP +      + T  A+D+D  G N+D+ Y ++    P     +D  +G +S    L
Sbjct: 1442 ALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGL 1501

Query: 808  TQKHYGLHRLVVQVND---SGQPSQSTTTLVHVFVNESVSNATAIDS 851
             ++      L+V+  D   +    ++      VFV +   NA    S
Sbjct: 1502 DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFAS 1548



 Score =  174 bits (442), Expect = 3e-43
 Identities = 204/801 (25%), Positives = 317/801 (39%), Gaps = 123/801 (15%)

Query: 52   ASDLGIVTGSGEVTFSLESGSE---YLKIDNLTGELSTSERRIDREKLPQCQMIFDENEC 108
            A DL   +G G++++SL +         +D  TG ++T+   +DRE   + +++      
Sbjct: 2195 ADDLDQGSG-GQISYSLAASQPARGLFHVDPTTGTITTTAI-LDREIWAETRLVL----- 2247

Query: 109  FLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTAT 168
                 ++    S + V      V+V+D NDN PT P P   L V E+  +G+     T  
Sbjct: 2248 -----MATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGN 2301

Query: 169  DRDFGRNGIERYELLQEPGG------GGSGGESRRAGAAD--------------SAPYPG 208
            D D   +G   + +L   G       G  GG     G  D                P+ G
Sbjct: 2302 DVD---SGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEG 2358

Query: 209  GGG----------NGASGGGS------------GGSKRRLDASEGGGGTNPGGRSSVFEL 246
                         N  +   S            G +   + A++   G N  G  S    
Sbjct: 2359 RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGAN--GHISYHLA 2416

Query: 247  QVAD----TPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVN 302
              AD     P+      ++   AL  +   + ++ L  RD G P R+++A + V + D N
Sbjct: 2417 SPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQN 2476

Query: 303  DNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVG-VNGQIEYV-----FGAATESVRR 356
            D++P F  S Y   + E+  PG+ +L L A D D    +  ++Y      +G   +   R
Sbjct: 2477 DHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPR 2536

Query: 357  LLRLDETSG-------WLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDEN 409
            L    E++G        L +L  +D E + Q   TV A DRGQPP++    V + + D N
Sbjct: 2537 LAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVN 2596

Query: 410  DNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQ 469
            DN P +  R   R+        V ED  V   +  V+ SD D G +G+V  TV    P  
Sbjct: 2597 DN-PPVFTRASYRV-------TVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSG 2648

Query: 470  LKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTN 529
            L    ++ G        L  +  LD E      +V+ A D      +    + ++V D N
Sbjct: 2649 LFELDESSGT-------LRLAHALDCETQARHQLVVQAADPAGAHFALA-PVTIEVQDVN 2700

Query: 530  DNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMG-----IFAI 584
            D+ P F  +++     EN  PG  V T+ A D D+G    + YSL  +  G      FA+
Sbjct: 2701 DHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFAL 2760

Query: 585  DPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVF 644
            +  +G++      D E T+ +   V A D G   L  S TV V V  +++ DP F+   F
Sbjct: 2761 NSSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAF 2818

Query: 645  TFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREH 704
             F V E  +    +G V   D D G +  +   +  ++  F I   TG +Y  +      
Sbjct: 2819 HFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPG 2878

Query: 705  QTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVA 764
              T T    +  GG   R A   + L V+                     P S   TV  
Sbjct: 2879 SGTAT----SGGGGRTRREAPRELRLEVIARGPL----------------PGSRSATVPV 2918

Query: 765  TVLATDSDDGINADLNYSIVG 785
            TV  T +  G+  DLN  +VG
Sbjct: 2919 TVDITHTALGLAPDLNLLLVG 2939



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 99/418 (23%), Positives = 158/418 (37%), Gaps = 95/418 (22%)

Query: 35   RYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESG--SEYLKIDNLTGELSTSERRID 92
            R  + E+ P    + +V +        G V F++ SG  S   ++D  +G L  +   +D
Sbjct: 2608 RVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHA-LD 2666

Query: 93   REKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTV 152
             E   + Q++           V    P+ +   L    + V D+ND+ P FP  +L+ +V
Sbjct: 2667 CETQARHQLV-----------VQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSV 2715

Query: 153  EENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGGGN 212
             EN+P GTL     A D D G  G  RY LL+     G G E R A A            
Sbjct: 2716 AENQPPGTLVTTLHAIDGDAGAFGRLRYSLLE----AGPGPEGREAFA------------ 2759

Query: 213  GASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRD 272
                         L++S G                           +L  +   D E  +
Sbjct: 2760 -------------LNSSTG---------------------------ELRARVPFDYEHTE 2779

Query: 273  SYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRA 332
            S+ L +   D G+   S+   + VL+T  ++  P F    +   + E +  G  +  ++A
Sbjct: 2780 SFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQA 2837

Query: 333  ADLDVGVNGQIEY-------VFGAATESVRRLLRLDE--------TSGWLSVLHRIDREE 377
             D D G +G + Y        FG    +    LR+D         TSG      R  RE 
Sbjct: 2838 TDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGG---RTRREA 2894

Query: 378  VNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNV---PSIEIRKIGRIPLKDGVANV 432
              +LR  V+A  RG  P +  ATV + +   +  +   P + +  +G +    GV  V
Sbjct: 2895 PRELRLEVIA--RGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVV 2950



 Score = 31.2 bits (69), Expect = 5.5
 Identities = 55/228 (24%), Positives = 83/228 (36%), Gaps = 29/228 (12%)

Query: 33   LLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSL------ESGSEYLKIDNLTGELST 86
            LL   +AE  P    +  + +  G     G + +SL        G E   +++ TGEL  
Sbjct: 2710 LLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGEL-- 2767

Query: 87   SERRIDREKLPQCQMIFDENECF-LDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPS 145
                  R ++P     ++  E F L    +  G   + V +    V+V   ++  P F +
Sbjct: 2768 ------RARVP---FDYEHTESFRLLVGAADAGNLSASVTV---SVLVTGEDEYDPVFLA 2815

Query: 146  PVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAP 205
            P     V E    G       ATD D G +G+  Y L          G ++  GA     
Sbjct: 2816 PAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLAT---SSPYFGINQTTGALYLRV 2872

Query: 206  YPGGGGNGASGGGSGGSKRR-----LDASEGGGGTNPGGRSSVFELQV 248
                 G+G +  G GG  RR     L       G  PG RS+   + V
Sbjct: 2873 DSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920


>gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precursor
           [Homo sapiens]
          Length = 818

 Score =  317 bits (813), Expect = 3e-86
 Identities = 229/731 (31%), Positives = 335/731 (45%), Gaps = 103/731 (14%)

Query: 20  LLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGI-VTGSGEVTFSLESGSEYLKID 78
           L  LSL   A  + +RYR+ EE P    +GN+A+DLG  V         + S   Y  + 
Sbjct: 19  LFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVS 78

Query: 79  NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDIND 138
             +GEL  S R +DRE++        +  C L+FE     P    ++ +   V + DIND
Sbjct: 79  AESGELLVSSR-LDREEI-----CGKKPACALEFEAVAENP----LNFYHVNVEIEDIND 128

Query: 139 NTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRA 198
           +TP F      L + E+   GT ++L  A D D G N +++Y+L   P       E +  
Sbjct: 129 HTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQ-- 186

Query: 199 GAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQP 258
              D + YP                                     EL +  T D     
Sbjct: 187 ---DGSKYP-------------------------------------ELALEKTLD----- 201

Query: 259 QLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLA 318
                    REQ+  + L L   DGG PP S    LR+ +TD NDN P F + VY   L 
Sbjct: 202 ---------REQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLR 252

Query: 319 ENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEV 378
           EN  PGT +LQ+ A D D G+N +I Y F        ++  L+  SG ++   ++D EE 
Sbjct: 253 ENVPPGTTVLQVSATDQDEGINSEITYSF----YRTGQIFSLNSKSGEITTQKKLDFEET 308

Query: 379 NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLV 438
            +    V  RD G      + TV +NI+DENDN P +    +        +  + E+ + 
Sbjct: 309 KEYSMVVEGRDGG--GLVAQCTVEINIQDENDNSPEVTFHSL--------LEMILENAVP 358

Query: 439 DTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEAT 498
            T IAL+++ D+D GENG V C + G+VPF++  +S       K  Y L T   LD E T
Sbjct: 359 GTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSS-------KNSYKLVTDGTLDREQT 411

Query: 499 REFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVL 558
            E+NV I A D G P LSS+ S+I+ + D NDN P+F Q+   V  PENN PG  +A V 
Sbjct: 412 PEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVC 471

Query: 559 ATDADSGKNAEIAYSLDSS------VMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAK 612
           A+D D G N +++YS+ +S      +    ++   SG +      D EQ   +E  + A+
Sbjct: 472 ASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQAR 531

Query: 613 DKGIPVLQGSTTVIVQVADKNDNDPKFMQ-------DVFTFYVKENLQPNSPVGMVTVMD 665
           D+G P L  + ++ V V D+NDN P+ +              V    +P   V  V  +D
Sbjct: 532 DQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVD 591

Query: 666 ADKGRNAEMSLYIEENN--NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRS 723
           AD G NA +S ++ + +   +FS+   TG + +  +            V   DGG PP S
Sbjct: 592 ADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLS 651

Query: 724 ATATVSLFVMD 734
           ATAT+ L   D
Sbjct: 652 ATATLHLVFAD 662



 Score =  237 bits (604), Expect = 5e-62
 Identities = 183/670 (27%), Positives = 314/670 (46%), Gaps = 56/670 (8%)

Query: 259 QLIVKGALDREQRDSYE--LTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEAD 316
           +L+V   LDRE+    +    L      + P +   +  V I D+ND++P+F ++ +E  
Sbjct: 83  ELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHV-NVEIEDINDHTPKFTQNSFELQ 141

Query: 317 LAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGW--LSVLHRID 374
           ++E++ PGT  +   A D D+G+N   +Y           +    + S +  L++   +D
Sbjct: 142 ISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLD 201

Query: 375 REEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAE 434
           RE+ +  R  + A D G PP +    + + + D NDN P    R + R+ L+       E
Sbjct: 202 REQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFN-RDVYRVSLR-------E 253

Query: 435 DVLVDTPIALVQVSDRDQGENGVVTCTV--VGDVPFQLKPASDTEGDQNKKKYFLHTSTP 492
           +V   T +  V  +D+D+G N  +T +    G + F L          N K   + T   
Sbjct: 254 NVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI-FSL----------NSKSGEITTQKK 302

Query: 493 LDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPP-MFGQSVVEVYFPENNIPG 551
           LD+E T+E+++V+   D G   L +  ++ + + D NDN P +   S++E+   EN +PG
Sbjct: 303 LDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQDENDNSPEVTFHSLLEMIL-ENAVPG 359

Query: 552 ERVATVLATDADSGKNAEIAYSLDSSV-MGIFAIDPDSGDILVNTVLDREQTDRYEFKVN 610
             +A +   D DSG+N E+   L   V   I +   +S  ++ +  LDREQT  Y   + 
Sbjct: 360 TLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTIT 419

Query: 611 AKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGR 670
           A D+G P L  S +VI+ + D NDN P F Q  +   V EN  P + +  V   D D G 
Sbjct: 420 ATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGL 479

Query: 671 NAEMSLYIEENN-------NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRS 723
           N ++S  I  ++       +  S+   +G +++  +FD E   T+   ++A D G P  S
Sbjct: 480 NGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALS 539

Query: 724 ATATVSLFVMDENDNAPTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGINAD 778
           A  ++ + V D NDNAP V  P      +  + ++P ++    +V  V+A D+D G NA 
Sbjct: 540 ANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAW 599

Query: 779 LNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVF 838
           L+Y ++  +   LF +   +G V     L  +     RL+V V D GQP  S T  +H+ 
Sbjct: 600 LSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLV 659

Query: 839 VNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIV 898
             +S+             L     + +  DP  E+   +  +V+ +    +  +L +++ 
Sbjct: 660 FADSLQEV----------LPDITDRPVPSDPQAEL---QFYLVVALALISVLFLLAVILA 706

Query: 899 VMARYCRSKN 908
           V  R  RS +
Sbjct: 707 VALRLRRSSS 716



 Score =  101 bits (252), Expect = 3e-21
 Identities = 80/269 (29%), Positives = 130/269 (48%), Gaps = 35/269 (13%)

Query: 576 SSVMGIFAIDPDSGDILVNTVLDREQ------TDRYEFKVNAKDKGIPVLQGSTTVIVQV 629
           SS    F +  +SG++LV++ LDRE+          EF+  A++           V V++
Sbjct: 69  SSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENP-----LNFYHVNVEI 123

Query: 630 ADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNA--EMSLYIEENNNIFSI 687
            D ND+ PKF Q+ F   + E+ QP +   +    DAD G N+  +  L +  + ++   
Sbjct: 124 EDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIK 183

Query: 688 ENDTGTIYSTM----SFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-- 741
           E   G+ Y  +    + DRE Q+ +   + A+DGG PP S T  + + V D NDN P   
Sbjct: 184 EKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFN 243

Query: 742 -----VTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDP 796
                V+L +N+     PP     T V  V ATD D+GIN+++ YS       ++F ++ 
Sbjct: 244 RDVYRVSLRENV-----PPG----TTVLQVSATDQDEGINSEITYSFY--RTGQIFSLNS 292

Query: 797 TSGVVSLVGKLTQKHYGLHRLVVQVNDSG 825
            SG ++   KL  +    + +VV+  D G
Sbjct: 293 KSGEITTQKKLDFEETKEYSMVVEGRDGG 321


>gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precursor
           [Homo sapiens]
          Length = 923

 Score =  317 bits (813), Expect = 3e-86
 Identities = 229/731 (31%), Positives = 335/731 (45%), Gaps = 103/731 (14%)

Query: 20  LLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGI-VTGSGEVTFSLESGSEYLKID 78
           L  LSL   A  + +RYR+ EE P    +GN+A+DLG  V         + S   Y  + 
Sbjct: 19  LFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVS 78

Query: 79  NLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDIND 138
             +GEL  S R +DRE++        +  C L+FE     P    ++ +   V + DIND
Sbjct: 79  AESGELLVSSR-LDREEI-----CGKKPACALEFEAVAENP----LNFYHVNVEIEDIND 128

Query: 139 NTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRA 198
           +TP F      L + E+   GT ++L  A D D G N +++Y+L   P       E +  
Sbjct: 129 HTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQ-- 186

Query: 199 GAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQP 258
              D + YP                                     EL +  T D     
Sbjct: 187 ---DGSKYP-------------------------------------ELALEKTLD----- 201

Query: 259 QLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLA 318
                    REQ+  + L L   DGG PP S    LR+ +TD NDN P F + VY   L 
Sbjct: 202 ---------REQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLR 252

Query: 319 ENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEV 378
           EN  PGT +LQ+ A D D G+N +I Y F        ++  L+  SG ++   ++D EE 
Sbjct: 253 ENVPPGTTVLQVSATDQDEGINSEITYSF----YRTGQIFSLNSKSGEITTQKKLDFEET 308

Query: 379 NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLV 438
            +    V  RD G      + TV +NI+DENDN P +    +        +  + E+ + 
Sbjct: 309 KEYSMVVEGRDGG--GLVAQCTVEINIQDENDNSPEVTFHSL--------LEMILENAVP 358

Query: 439 DTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEAT 498
            T IAL+++ D+D GENG V C + G+VPF++  +S       K  Y L T   LD E T
Sbjct: 359 GTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSS-------KNSYKLVTDGTLDREQT 411

Query: 499 REFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVL 558
            E+NV I A D G P LSS+ S+I+ + D NDN P+F Q+   V  PENN PG  +A V 
Sbjct: 412 PEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVC 471

Query: 559 ATDADSGKNAEIAYSLDSS------VMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAK 612
           A+D D G N +++YS+ +S      +    ++   SG +      D EQ   +E  + A+
Sbjct: 472 ASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQAR 531

Query: 613 DKGIPVLQGSTTVIVQVADKNDNDPKFMQ-------DVFTFYVKENLQPNSPVGMVTVMD 665
           D+G P L  + ++ V V D+NDN P+ +              V    +P   V  V  +D
Sbjct: 532 DQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVD 591

Query: 666 ADKGRNAEMSLYIEENN--NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRS 723
           AD G NA +S ++ + +   +FS+   TG + +  +            V   DGG PP S
Sbjct: 592 ADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLS 651

Query: 724 ATATVSLFVMD 734
           ATAT+ L   D
Sbjct: 652 ATATLHLVFAD 662



 Score =  237 bits (604), Expect = 5e-62
 Identities = 183/670 (27%), Positives = 314/670 (46%), Gaps = 56/670 (8%)

Query: 259 QLIVKGALDREQRDSYE--LTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEAD 316
           +L+V   LDRE+    +    L      + P +   +  V I D+ND++P+F ++ +E  
Sbjct: 83  ELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHV-NVEIEDINDHTPKFTQNSFELQ 141

Query: 317 LAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGW--LSVLHRID 374
           ++E++ PGT  +   A D D+G+N   +Y           +    + S +  L++   +D
Sbjct: 142 ISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLD 201

Query: 375 REEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAE 434
           RE+ +  R  + A D G PP +    + + + D NDN P    R + R+ L+       E
Sbjct: 202 REQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFN-RDVYRVSLR-------E 253

Query: 435 DVLVDTPIALVQVSDRDQGENGVVTCTV--VGDVPFQLKPASDTEGDQNKKKYFLHTSTP 492
           +V   T +  V  +D+D+G N  +T +    G + F L          N K   + T   
Sbjct: 254 NVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI-FSL----------NSKSGEITTQKK 302

Query: 493 LDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPP-MFGQSVVEVYFPENNIPG 551
           LD+E T+E+++V+   D G   L +  ++ + + D NDN P +   S++E+   EN +PG
Sbjct: 303 LDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQDENDNSPEVTFHSLLEMIL-ENAVPG 359

Query: 552 ERVATVLATDADSGKNAEIAYSLDSSV-MGIFAIDPDSGDILVNTVLDREQTDRYEFKVN 610
             +A +   D DSG+N E+   L   V   I +   +S  ++ +  LDREQT  Y   + 
Sbjct: 360 TLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTIT 419

Query: 611 AKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGR 670
           A D+G P L  S +VI+ + D NDN P F Q  +   V EN  P + +  V   D D G 
Sbjct: 420 ATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGL 479

Query: 671 NAEMSLYIEENN-------NIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRS 723
           N ++S  I  ++       +  S+   +G +++  +FD E   T+   ++A D G P  S
Sbjct: 480 NGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALS 539

Query: 724 ATATVSLFVMDENDNAPTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGINAD 778
           A  ++ + V D NDNAP V  P      +  + ++P ++    +V  V+A D+D G NA 
Sbjct: 540 ANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAW 599

Query: 779 LNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVF 838
           L+Y ++  +   LF +   +G V     L  +     RL+V V D GQP  S T  +H+ 
Sbjct: 600 LSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLV 659

Query: 839 VNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIV 898
             +S+             L     + +  DP  E+   +  +V+ +    +  +L +++ 
Sbjct: 660 FADSLQEV----------LPDITDRPVPSDPQAEL---QFYLVVALALISVLFLLAVILA 706

Query: 899 VMARYCRSKN 908
           V  R  RS +
Sbjct: 707 VALRLRRSSS 716



 Score =  101 bits (252), Expect = 3e-21
 Identities = 80/269 (29%), Positives = 130/269 (48%), Gaps = 35/269 (13%)

Query: 576 SSVMGIFAIDPDSGDILVNTVLDREQ------TDRYEFKVNAKDKGIPVLQGSTTVIVQV 629
           SS    F +  +SG++LV++ LDRE+          EF+  A++           V V++
Sbjct: 69  SSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENP-----LNFYHVNVEI 123

Query: 630 ADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNA--EMSLYIEENNNIFSI 687
            D ND+ PKF Q+ F   + E+ QP +   +    DAD G N+  +  L +  + ++   
Sbjct: 124 EDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIK 183

Query: 688 ENDTGTIYSTM----SFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPT-- 741
           E   G+ Y  +    + DRE Q+ +   + A+DGG PP S T  + + V D NDN P   
Sbjct: 184 EKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFN 243

Query: 742 -----VTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDP 796
                V+L +N+     PP     T V  V ATD D+GIN+++ YS       ++F ++ 
Sbjct: 244 RDVYRVSLRENV-----PPG----TTVLQVSATDQDEGINSEITYSFY--RTGQIFSLNS 292

Query: 797 TSGVVSLVGKLTQKHYGLHRLVVQVNDSG 825
            SG ++   KL  +    + +VV+  D G
Sbjct: 293 KSGEITTQKKLDFEETKEYSMVVEGRDGG 321


>gi|9256586 protocadherin alpha 3 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  315 bits (808), Expect = 1e-85
 Identities = 243/748 (32%), Positives = 349/748 (46%), Gaps = 109/748 (14%)

Query: 18  CLLLPLSLSLAAAKQL----LRYRLAEEGPADVRIGNVASDLGIVTGS---GEVTFSLES 70
           CLLL  SL L AA ++    L Y ++EE      +G +A DLG+            + + 
Sbjct: 13  CLLL--SLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKR 70

Query: 71  GSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQ 130
             + L+++   G L  + R IDRE+L  C       EC +  EV V  P Q    +F  +
Sbjct: 71  HGDLLEVNLQNGILFVNSR-IDREEL--CGR---SAECSIHLEVIVDRPLQ----VFHVE 120

Query: 131 VIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGG 190
           V V DINDN P FP  V  L + E+R  G+ + L  A+D D G N +  Y L        
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSL-------- 172

Query: 191 SGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVAD 250
                      DS  Y                                     F L V  
Sbjct: 173 -----------DSTEY-------------------------------------FTLDVKR 184

Query: 251 TPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEK 310
             +  K   L++K  L+RE    + L +   DGG P  +    L++ + DVNDN+P FE+
Sbjct: 185 NDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFER 244

Query: 311 SVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGA-ATESVRRLLRLDETSGWLSV 369
           ++Y+  L EN+  GT ++ + A DLD GVN  I Y F    +  +     LD  +G +SV
Sbjct: 245 TIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISV 304

Query: 370 LHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGV 429
              ID EE       V A D+G PP +D  TV+L I D NDNVP + I+ +  +P     
Sbjct: 305 KGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLS-LP----- 358

Query: 430 ANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHT 489
             V ED  + T IAL+ VSDRD G NG VTC++   VPF+L           K  Y L  
Sbjct: 359 --VLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTF-------KNYYSLVL 409

Query: 490 STPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNI 549
            +PLD E+   + +V+ A D GSPSL +  S+ V+V D NDN P F QS   V+  ENN 
Sbjct: 410 DSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNP 469

Query: 550 PGERVATVLATDADSGKNAEIAYSL------DSSVMGIFAIDPDSGDILVNTVLDREQTD 603
           PG  + TV A DAD+ +NA ++YSL      + ++    ++  +SG +     LD E+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELE 529

Query: 604 RYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQ-------DVFTFYVKENLQPNS 656
             +F+V+A+D G+P L  + T+ V V D+NDN P  +           +  V  ++    
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGH 589

Query: 657 PVGMVTVMDADKGRNAEMSLYIEENNN----IFSIENDTGTIYSTMSFDREHQTTYTFRV 712
            V  V  +DAD G NA +S  ++         F +   TG I +T + D      +   V
Sbjct: 590 VVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPRHRLLV 649

Query: 713 KAVDGGDPPRSATATVSLFVMDENDNAP 740
              D G+P  +ATATV L  + E+  AP
Sbjct: 650 LVKDHGEPSLTATATV-LVSLVESGQAP 676



 Score =  233 bits (593), Expect = 9e-61
 Identities = 184/678 (27%), Positives = 313/678 (46%), Gaps = 57/678 (8%)

Query: 260 LIVKGALDREQR--DSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317
           L V   +DRE+    S E ++ +    D P     +  V + D+NDN+P F  +V    +
Sbjct: 84  LFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHV-EVEVKDINDNAPVFPMAVKNLFI 142

Query: 318 AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHR--IDR 375
           +E+  PG+      A+D D+G N  + Y   +       + R DE    L ++ +  ++R
Sbjct: 143 SESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTLDVKRNDEEIKSLGLVLKKNLNR 202

Query: 376 EEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAED 435
           E+  +    + A D G+P  T    + + + D NDN P+ E R I ++ L +   N    
Sbjct: 203 EDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFE-RTIYKVRLLENAPN---- 257

Query: 436 VLVDTPIALVQVSDRDQGENGVVTCTVVGDVP------FQLKPASDTEGDQNKKKYFLHT 489
               T +  V  +D D+G N  +  +   D+       F L P +            +  
Sbjct: 258 ---GTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQ----------ISV 304

Query: 490 STPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNI 549
              +D+E ++ + + + A D G+P +S + ++++++ D NDN P      + +   E++ 
Sbjct: 305 KGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSP 364

Query: 550 PGERVATVLATDADSGKNAEIAYSLDSSV-MGIFAIDPDSGDILVNTVLDREQTDRYEFK 608
               +A +  +D DSG N ++  SL   V   + +   +   +++++ LDRE    YE  
Sbjct: 365 LSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELV 424

Query: 609 VNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADK 668
           V A+D G P L  + +V V+VAD NDN P F Q  +T +VKEN  P   +  V+  DAD 
Sbjct: 425 VTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADA 484

Query: 669 GRNAEMSLYIEEN-------NNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPP 721
             NA +S  + E        ++  S+  ++G +Y+    D E      F+V A D G PP
Sbjct: 485 QENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPP 544

Query: 722 RSATATVSLFVMDENDNAPTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGIN 776
             +  T+ +FV+DENDNAP + +P+          L+P S     VVA V A D+D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVDADSGYN 604

Query: 777 ADLNYSI---VGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTT 833
           A L+Y +    GG     F +   +G +S    L +     HRL+V V D G+PS + T 
Sbjct: 605 AWLSYELQPGTGGARIP-FRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATA 663

Query: 834 LVHVFVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVIL 893
            V V + ES   A    SQ +           A  P   +    + +++ + A + ++++
Sbjct: 664 TVLVSLVES-GQAPKASSQASAG---------ATGPEAALVDVNVYLIVAICA-VSSLLV 712

Query: 894 IILIVVMARYCRSKNKNG 911
           + L++  A  C +    G
Sbjct: 713 LTLLLYTALRCSAPPTEG 730



 Score =  182 bits (463), Expect = 1e-45
 Identities = 161/552 (29%), Positives = 257/552 (46%), Gaps = 40/552 (7%)

Query: 317 LAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDRE 376
           ++E +  GT + ++ A DL + +   +  +F  A++    LL ++  +G L V  RIDRE
Sbjct: 35  VSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDRE 93

Query: 377 EV------NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVA 430
           E+        +   V+  DR          V + +KD NDN P          P+     
Sbjct: 94  ELCGRSAECSIHLEVIV-DR----PLQVFHVEVEVKDINDNAPV--------FPMAVKNL 140

Query: 431 NVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTS 490
            ++E     +  +L   SD D G N ++T ++     F L        D+  K   L   
Sbjct: 141 FISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTL---DVKRNDEEIKSLGLVLK 197

Query: 491 TPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIP 550
             L+ E T +  ++I A+D G P L+    L + V D NDN P F +++ +V   EN   
Sbjct: 198 KNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLENAPN 257

Query: 551 GERVATVLATDADSGKNAEIAYS----LDSSVMGIFAIDPDSGDILVNTVLDREQTDRYE 606
           G  V TV ATD D G N +IAYS    + + ++  F +DP +G I V   +D E++  YE
Sbjct: 258 GTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEESKSYE 317

Query: 607 FKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDA 666
            +V A DKG P +    TV++++ D NDN P+ +    +  V E+   ++ + +++V D 
Sbjct: 318 IQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVIALISVSDR 377

Query: 667 DKGRNAEMSLYIEENNNIFSIENDTGTIYSTM---SFDREHQTTYTFRVKAVDGGDPPRS 723
           D G N +++  +  +   F + +     YS +     DRE  + Y   V A DGG P   
Sbjct: 378 DSGVNGQVTCSLTPHVP-FKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLW 436

Query: 724 ATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTV-VATVLATDSDDGINADLNYS 782
           ATA+VS+ V D NDNAP  +      YT+    +N     + TV A D+D   NA ++YS
Sbjct: 437 ATASVSVEVADVNDNAPAFS---QSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS 493

Query: 783 I----VGGNPFKLF-EIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 837
           +    VG      +  +   SG V  +  L  +   L +  V   D+G P   +   + V
Sbjct: 494 LVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQV 553

Query: 838 FVNESVSNATAI 849
           FV +   NA A+
Sbjct: 554 FVLDENDNAPAL 565


>gi|14165410 protocadherin alpha 3 isoform 2 precursor [Homo
           sapiens]
          Length = 824

 Score =  315 bits (808), Expect = 1e-85
 Identities = 243/748 (32%), Positives = 349/748 (46%), Gaps = 109/748 (14%)

Query: 18  CLLLPLSLSLAAAKQL----LRYRLAEEGPADVRIGNVASDLGIVTGS---GEVTFSLES 70
           CLLL  SL L AA ++    L Y ++EE      +G +A DLG+            + + 
Sbjct: 13  CLLL--SLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKR 70

Query: 71  GSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQ 130
             + L+++   G L  + R IDRE+L  C       EC +  EV V  P Q    +F  +
Sbjct: 71  HGDLLEVNLQNGILFVNSR-IDREEL--CGR---SAECSIHLEVIVDRPLQ----VFHVE 120

Query: 131 VIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGG 190
           V V DINDN P FP  V  L + E+R  G+ + L  A+D D G N +  Y L        
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSL-------- 172

Query: 191 SGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVAD 250
                      DS  Y                                     F L V  
Sbjct: 173 -----------DSTEY-------------------------------------FTLDVKR 184

Query: 251 TPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEK 310
             +  K   L++K  L+RE    + L +   DGG P  +    L++ + DVNDN+P FE+
Sbjct: 185 NDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFER 244

Query: 311 SVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGA-ATESVRRLLRLDETSGWLSV 369
           ++Y+  L EN+  GT ++ + A DLD GVN  I Y F    +  +     LD  +G +SV
Sbjct: 245 TIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISV 304

Query: 370 LHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGV 429
              ID EE       V A D+G PP +D  TV+L I D NDNVP + I+ +  +P     
Sbjct: 305 KGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLS-LP----- 358

Query: 430 ANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHT 489
             V ED  + T IAL+ VSDRD G NG VTC++   VPF+L           K  Y L  
Sbjct: 359 --VLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTF-------KNYYSLVL 409

Query: 490 STPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNI 549
            +PLD E+   + +V+ A D GSPSL +  S+ V+V D NDN P F QS   V+  ENN 
Sbjct: 410 DSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNP 469

Query: 550 PGERVATVLATDADSGKNAEIAYSL------DSSVMGIFAIDPDSGDILVNTVLDREQTD 603
           PG  + TV A DAD+ +NA ++YSL      + ++    ++  +SG +     LD E+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELE 529

Query: 604 RYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQ-------DVFTFYVKENLQPNS 656
             +F+V+A+D G+P L  + T+ V V D+NDN P  +           +  V  ++    
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGH 589

Query: 657 PVGMVTVMDADKGRNAEMSLYIEENNN----IFSIENDTGTIYSTMSFDREHQTTYTFRV 712
            V  V  +DAD G NA +S  ++         F +   TG I +T + D      +   V
Sbjct: 590 VVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPRHRLLV 649

Query: 713 KAVDGGDPPRSATATVSLFVMDENDNAP 740
              D G+P  +ATATV L  + E+  AP
Sbjct: 650 LVKDHGEPSLTATATV-LVSLVESGQAP 676



 Score =  233 bits (593), Expect = 9e-61
 Identities = 184/678 (27%), Positives = 313/678 (46%), Gaps = 57/678 (8%)

Query: 260 LIVKGALDREQR--DSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317
           L V   +DRE+    S E ++ +    D P     +  V + D+NDN+P F  +V    +
Sbjct: 84  LFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHV-EVEVKDINDNAPVFPMAVKNLFI 142

Query: 318 AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHR--IDR 375
           +E+  PG+      A+D D+G N  + Y   +       + R DE    L ++ +  ++R
Sbjct: 143 SESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTLDVKRNDEEIKSLGLVLKKNLNR 202

Query: 376 EEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAED 435
           E+  +    + A D G+P  T    + + + D NDN P+ E R I ++ L +   N    
Sbjct: 203 EDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFE-RTIYKVRLLENAPN---- 257

Query: 436 VLVDTPIALVQVSDRDQGENGVVTCTVVGDVP------FQLKPASDTEGDQNKKKYFLHT 489
               T +  V  +D D+G N  +  +   D+       F L P +            +  
Sbjct: 258 ---GTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQ----------ISV 304

Query: 490 STPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNI 549
              +D+E ++ + + + A D G+P +S + ++++++ D NDN P      + +   E++ 
Sbjct: 305 KGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSP 364

Query: 550 PGERVATVLATDADSGKNAEIAYSLDSSV-MGIFAIDPDSGDILVNTVLDREQTDRYEFK 608
               +A +  +D DSG N ++  SL   V   + +   +   +++++ LDRE    YE  
Sbjct: 365 LSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELV 424

Query: 609 VNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADK 668
           V A+D G P L  + +V V+VAD NDN P F Q  +T +VKEN  P   +  V+  DAD 
Sbjct: 425 VTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADA 484

Query: 669 GRNAEMSLYIEEN-------NNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPP 721
             NA +S  + E        ++  S+  ++G +Y+    D E      F+V A D G PP
Sbjct: 485 QENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPP 544

Query: 722 RSATATVSLFVMDENDNAPTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGIN 776
             +  T+ +FV+DENDNAP + +P+          L+P S     VVA V A D+D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVDADSGYN 604

Query: 777 ADLNYSI---VGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTT 833
           A L+Y +    GG     F +   +G +S    L +     HRL+V V D G+PS + T 
Sbjct: 605 AWLSYELQPGTGGARIP-FRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATA 663

Query: 834 LVHVFVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVIL 893
            V V + ES   A    SQ +           A  P   +    + +++ + A + ++++
Sbjct: 664 TVLVSLVES-GQAPKASSQASAG---------ATGPEAALVDVNVYLIVAICA-VSSLLV 712

Query: 894 IILIVVMARYCRSKNKNG 911
           + L++  A  C +    G
Sbjct: 713 LTLLLYTALRCSAPPTEG 730



 Score =  182 bits (463), Expect = 1e-45
 Identities = 161/552 (29%), Positives = 257/552 (46%), Gaps = 40/552 (7%)

Query: 317 LAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDRE 376
           ++E +  GT + ++ A DL + +   +  +F  A++    LL ++  +G L V  RIDRE
Sbjct: 35  VSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDRE 93

Query: 377 EV------NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVA 430
           E+        +   V+  DR          V + +KD NDN P          P+     
Sbjct: 94  ELCGRSAECSIHLEVIV-DR----PLQVFHVEVEVKDINDNAPV--------FPMAVKNL 140

Query: 431 NVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTS 490
            ++E     +  +L   SD D G N ++T ++     F L        D+  K   L   
Sbjct: 141 FISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTL---DVKRNDEEIKSLGLVLK 197

Query: 491 TPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIP 550
             L+ E T +  ++I A+D G P L+    L + V D NDN P F +++ +V   EN   
Sbjct: 198 KNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLENAPN 257

Query: 551 GERVATVLATDADSGKNAEIAYS----LDSSVMGIFAIDPDSGDILVNTVLDREQTDRYE 606
           G  V TV ATD D G N +IAYS    + + ++  F +DP +G I V   +D E++  YE
Sbjct: 258 GTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEESKSYE 317

Query: 607 FKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDA 666
            +V A DKG P +    TV++++ D NDN P+ +    +  V E+   ++ + +++V D 
Sbjct: 318 IQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVIALISVSDR 377

Query: 667 DKGRNAEMSLYIEENNNIFSIENDTGTIYSTM---SFDREHQTTYTFRVKAVDGGDPPRS 723
           D G N +++  +  +   F + +     YS +     DRE  + Y   V A DGG P   
Sbjct: 378 DSGVNGQVTCSLTPHVP-FKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLW 436

Query: 724 ATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTV-VATVLATDSDDGINADLNYS 782
           ATA+VS+ V D NDNAP  +      YT+    +N     + TV A D+D   NA ++YS
Sbjct: 437 ATASVSVEVADVNDNAPAFS---QSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS 493

Query: 783 I----VGGNPFKLF-EIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHV 837
           +    VG      +  +   SG V  +  L  +   L +  V   D+G P   +   + V
Sbjct: 494 LVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQV 553

Query: 838 FVNESVSNATAI 849
           FV +   NA A+
Sbjct: 554 FVLDENDNAPAL 565


>gi|11036656 protocadherin beta 7 precursor [Homo sapiens]
          Length = 793

 Score =  312 bits (800), Expect = 9e-85
 Identities = 233/769 (30%), Positives = 358/769 (46%), Gaps = 124/769 (16%)

Query: 23  LSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVT-----FSLESGSEYLKI 77
           L +S A A+ L RY +AEE      + N+A DLG+  G GE+         +   + L +
Sbjct: 21  LGMSWAGAEPL-RYFVAEETERGTFLTNLAKDLGL--GVGELRARGTRIVSDQNMQILLL 77

Query: 78  DNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDIN 137
            +LTG+L  +E+ +DRE+L           C L F++ +  P Q    +F  ++ V DIN
Sbjct: 78  SSLTGDLLLNEK-LDREEL-----CGPREPCVLPFQLLLEKPFQ----IFRAELWVRDIN 127

Query: 138 DNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRR 197
           D+ P F    ++L + E+   G  +LL +A D D G N +  Y +               
Sbjct: 128 DHAPVFLDREISLKILESTTPGAAFLLESAQDSDVGTNSLSNYTI--------------- 172

Query: 198 AGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQ 257
                                S  +   ++  + G G      +   EL +    D E+ 
Sbjct: 173 ---------------------SPNAYFHINVHDSGEG------NIYPELVLNQVLDREEI 205

Query: 258 PQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADL 317
           P+              + LTL   DGG PPRS  A++R+L+ DVNDN+P F +S+Y+  +
Sbjct: 206 PE--------------FSLTLTALDGGSPPRSGTALVRILVLDVNDNAPDFVRSLYKVQV 251

Query: 318 AENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREE 377
            ENS  G+ ++ + A DLD G NG+I Y F  ATE + +  +++ TSG L +  ++D E 
Sbjct: 252 PENSPVGSMVVSVSARDLDTGSNGEIAYAFSYATERILKTFQINPTSGSLHLKAQLDYEA 311

Query: 378 VNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVL 437
           +     T+ A+D G    + K TVV+++ D NDN P + +  +         + +AE+  
Sbjct: 312 IQTYTLTIQAKDGG--GLSGKCTVVVDVTDINDNRPELLLSSL--------TSPIAEN-S 360

Query: 438 VDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEA 497
            +T +A+ ++ DRD G NG   C++  DVPF LKP+ +         Y L T  PLD E 
Sbjct: 361 PETVVAVFRIRDRDSGNNGKTVCSIQDDVPFILKPSVE-------NFYTLVTEKPLDRER 413

Query: 498 TREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATV 557
             E+N+ I   D G+P L + +++ V V D NDN P F Q+   ++  ENN P   + +V
Sbjct: 414 NTEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALPIGSV 473

Query: 558 LATDADSGKNAEIAYSLDSS------VMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNA 611
            ATD DSG NA++ YSL  S      +  + +I+ D+G +     LD E    +EF+V A
Sbjct: 474 SATDRDSGTNAQVIYSLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGA 533

Query: 612 KDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKEN------------LQPNSPVG 659
            D+G P L     V V V D NDN P      F  Y  +N             +P   V 
Sbjct: 534 TDRGSPALSSEALVRVLVLDANDNSP------FVLYPLQNSSAPCTEPLPRAAEPGYLVT 587

Query: 660 MVTVMDADKGRNAEMS--LYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDG 717
            V  +D D G+NA +S  L       +F +    G + +               V   D 
Sbjct: 588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDN 647

Query: 718 GDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATV 766
           G+PPRSATAT+ + ++D   + P + LP+       P  +N  TV   V
Sbjct: 648 GEPPRSATATLHVLLVD-GFSQPYLRLPE-----AAPDQANSLTVYLVV 690



 Score =  229 bits (584), Expect = 1e-59
 Identities = 185/629 (29%), Positives = 283/629 (44%), Gaps = 59/629 (9%)

Query: 298 ITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRL 357
           + D+ND++P F        + E++ PG   L   A D DVG N    Y    +  +   +
Sbjct: 123 VRDINDHAPVFLDREISLKILESTTPGAAFLLESAQDSDVGTNSLSNYTI--SPNAYFHI 180

Query: 358 LRLDETSGWLS---VLHRI-DREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVP 413
              D   G +    VL+++ DREE+ +   T+ A D G PP++  A V + + D NDN P
Sbjct: 181 NVHDSGEGNIYPELVLNQVLDREEIPEFSLTLTALDGGSPPRSGTALVRILVLDVNDNAP 240

Query: 414 SIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVP-----F 468
              +R + ++        V E+  V + +  V   D D G NG +              F
Sbjct: 241 DF-VRSLYKV-------QVPENSPVGSMVVSVSARDLDTGSNGEIAYAFSYATERILKTF 292

Query: 469 QLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDT 528
           Q+ P S +          LH    LDYEA + + + I A D G   LS   +++V V D 
Sbjct: 293 QINPTSGS----------LHLKAQLDYEAIQTYTLTIQAKDGGG--LSGKCTVVVDVTDI 340

Query: 529 NDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDS 588
           NDN P    S +     EN+ P   VA     D DSG N +   S+   V  I     ++
Sbjct: 341 NDNRPELLLSSLTSPIAENS-PETVVAVFRIRDRDSGNNGKTVCSIQDDVPFILKPSVEN 399

Query: 589 GDILVNTV-LDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFY 647
              LV    LDRE+   Y   +   D G P L+    + V V+D NDN P F Q  +T +
Sbjct: 400 FYTLVTEKPLDRERNTEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLF 459

Query: 648 VKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNN-------IFSIENDTGTIYSTMSF 700
           V+EN  P  P+G V+  D D G NA++   +  + +       + SI  D G +++  S 
Sbjct: 460 VRENNSPALPIGSVSATDRDSGTNAQVIYSLLPSQDPHLPLASLVSINADNGHLFALRSL 519

Query: 701 DREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTL----LPPS 756
           D E    + FRV A D G P  S+ A V + V+D NDN+P V  P   S       LP +
Sbjct: 520 DYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNSSAPCTEPLPRA 579

Query: 757 SNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHR 816
           +    +V  V+A D D G NA L+Y ++      LF +   +G V     L+++     R
Sbjct: 580 AEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQR 639

Query: 817 LVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQ 876
           LVV V D+G+P +S T  +HV +         +D      L +P   + A D +  ++  
Sbjct: 640 LVVLVKDNGEPPRSATATLHVLL---------VDGFSQPYLRLP---EAAPDQANSLT-- 685

Query: 877 RLSIVIGVVAGIMTVILIILIVVMARYCR 905
            + +V+ + +     +L +L+ V  R CR
Sbjct: 686 -VYLVVALASVSSLFLLSVLLFVAVRLCR 713


>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
          Length = 1040

 Score =  312 bits (799), Expect = 1e-84
 Identities = 237/758 (31%), Positives = 344/758 (45%), Gaps = 124/758 (16%)

Query: 19  LLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGI----VTGSGEVTFSLESGSEY 74
           LL  L   +      L Y + EE      +GN+A DLG+    ++  G  T    S + Y
Sbjct: 5   LLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVP-NSRTPY 63

Query: 75  LKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVL 134
           L ++  TG L  +E+ IDRE++  C+       C L  EV +  P    ++LF+ ++ VL
Sbjct: 64  LDLNLETGVLYVNEK-IDREQI--CKQ---SPSCVLHLEVFLENP----LELFQVEIEVL 113

Query: 135 DINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYEL---------LQE 185
           DINDN P+FP P LT+ + E+   GT + L +A D D G N +  YE+         +Q 
Sbjct: 114 DINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQT 173

Query: 186 PGGGGSGGESRRAGAADS----------APYPGGGGNGASGGGSGGSKRRLDASEGGGGT 235
            G G    E       D               GGGG G   GG GG         GG G 
Sbjct: 174 QGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGG---------GGAGL 224

Query: 236 NPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILR 295
            P                                                  R+  A+L 
Sbjct: 225 PP-----------------------------------------------QQQRTGTALLT 237

Query: 296 VLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGA-ATESV 354
           + + D NDN P F++ VY   L ENS PGT ++QL A D D G NG++ Y F +  +   
Sbjct: 238 IRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRA 297

Query: 355 RRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPS 414
           R L  L   +G L V   +D EE    +  V A+D G         V++ + D NDN P 
Sbjct: 298 RELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPE 357

Query: 415 IEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPAS 474
           I    +           V+E     T +AL  V+DRD  ENG V C ++GDVPF+LK + 
Sbjct: 358 ISFSTVKEA--------VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSF 409

Query: 475 DTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPM 534
                  K  Y + T  PLD EA   + + +VA D G P+LS++ S+ V+V D NDN P 
Sbjct: 410 -------KNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPR 462

Query: 535 FGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSL------DSSVMGIFAIDPDS 588
           F Q V +VY  ENN+PG  +  V ATD D G NA++AYS+        SV    +I+ ++
Sbjct: 463 FSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSEN 522

Query: 589 GDILVNTVLDREQTDRYEFKVNAKDKGIP-VLQGSTTVIVQVADKNDNDPKFMQDV---- 643
           G +      D EQ   + F+V A+D G P  L G+ TV + + D+NDN P  +  +    
Sbjct: 523 GYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRN 582

Query: 644 ---FTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENN--NIFSIENDTGTIYST- 697
                  +  + +P   +  V  +DAD G NA ++  I   N  N+F ++  TG + +  
Sbjct: 583 GTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTAR 642

Query: 698 -MSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMD 734
            +   R+ Q  Y   ++  D G PP S+TAT+ + ++D
Sbjct: 643 RVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680



 Score =  234 bits (597), Expect = 3e-61
 Identities = 192/660 (29%), Positives = 310/660 (46%), Gaps = 66/660 (10%)

Query: 294 LRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATES 353
           + + + D+NDN P F +     +++E++ PGT      A D DVG N   +Y       +
Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEI-----T 162

Query: 354 VRRLLRLD-ETSG------WLSVLHRIDREEVNQLRFTVMARDRG--------------- 391
                 LD +T G       L +   +DRE+    R+ + A D G               
Sbjct: 163 PNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGA 222

Query: 392 ----QPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQV 447
               Q  +T  A + + + D NDNVP+ +              ++ E+    T +  +  
Sbjct: 223 GLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVY--------TVSLPENSPPGTLVIQLNA 274

Query: 448 SDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVA 507
           +D D+G+NG     VV      + P +      + +   L  S  LDYE +  + V + A
Sbjct: 275 TDPDEGQNG----EVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQA 330

Query: 508 VDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKN 567
            D G  ++ ++  ++V+V D NDN P    S V+    E   PG  VA    TD DS +N
Sbjct: 331 KDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEEN 390

Query: 568 AEIAYSLDSSV-MGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVI 626
            ++   L   V   + +   +   I+    LDRE  D Y   V A+D+G P L  S ++ 
Sbjct: 391 GQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQ 450

Query: 627 VQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEE----NN 682
           VQV+D NDN P+F Q V+  YV EN  P + +  V+  D D+G NA+++  I E      
Sbjct: 451 VQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGM 510

Query: 683 NIF---SIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSA-TATVSLFVMDENDN 738
           ++F   SI ++ G +Y+  SFD E    ++F+V+A D G P   A  ATV++ ++D+NDN
Sbjct: 511 SVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDN 570

Query: 739 APTVTLPK-----NISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFE 793
           AP +  P        +  +LP S+    ++  V A D+DDG NA L YSIV GN   LF 
Sbjct: 571 APAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFR 630

Query: 794 IDPTSGVVSLVGKLTQKH--YGLHRLVVQVNDSGQPS-QSTTTLVHVFVNESVSNATAID 850
           +D  +G +    ++  K      + LV++V D GQP   ST TLV   V+ +V       
Sbjct: 631 MDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVDGAVEPQGGGG 690

Query: 851 SQIARS-LHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNK 909
           S    S  H   ++   G+ S +     L++++ +  G ++ I ++ ++V+A  C+ + K
Sbjct: 691 SGGGGSGEHQRPSRSGGGETSLD-----LTLILIIALGSVSFIFLLAMIVLAVRCQKEKK 745


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.133    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,678,615
Number of Sequences: 37866
Number of extensions: 2185990
Number of successful extensions: 24963
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 344
Number of HSP's successfully gapped in prelim test: 235
Number of HSP's that attempted gapping in prelim test: 9969
Number of HSP's gapped (non-prelim): 4999
length of query: 1072
length of database: 18,247,518
effective HSP length: 113
effective length of query: 959
effective length of database: 13,968,660
effective search space: 13395944940
effective search space used: 13395944940
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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