Guide to the Human Genome
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Search of human proteins with 83921609

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|83921609 hypothetical protein LOC127254 [Homo sapiens]
         (1530 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|83921609 hypothetical protein LOC127254 [Homo sapiens]            3015   0.0  
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]             116   1e-25
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...   103   2e-21
gi|150170670 piccolo isoform 2 [Homo sapiens]                          87   1e-16
gi|150378539 piccolo isoform 1 [Homo sapiens]                          87   1e-16
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    84   1e-15
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        81   9e-15
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        81   9e-15
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         81   9e-15
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         81   9e-15
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         81   9e-15
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         81   9e-15
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         81   9e-15
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         81   9e-15
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       79   4e-14
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     76   3e-13
gi|87299628 biorientation of chromosomes in cell division 1-like...    74   1e-12
gi|38176300 nestin [Homo sapiens]                                      73   2e-12
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa...    72   4e-12
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa...    72   4e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    71   7e-12
gi|148746195 trichohyalin [Homo sapiens]                               70   1e-11
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         69   3e-11
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    69   3e-11
gi|7657138 golgi integral membrane protein 4 [Homo sapiens]            69   3e-11
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    68   6e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    68   6e-11
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    67   1e-10
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    67   1e-10
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    67   1e-10

>gi|83921609 hypothetical protein LOC127254 [Homo sapiens]
          Length = 1530

 Score = 3015 bits (7816), Expect = 0.0
 Identities = 1530/1530 (100%), Positives = 1530/1530 (100%)

Query: 1    MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRD 60
            MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRD
Sbjct: 1    MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRD 60

Query: 61   HQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPIL 120
            HQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPIL
Sbjct: 61   HQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPIL 120

Query: 121  SPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPK 180
            SPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPK
Sbjct: 121  SPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPK 180

Query: 181  VTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPP 240
            VTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPP
Sbjct: 181  VTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPP 240

Query: 241  TGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHL 300
            TGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHL
Sbjct: 241  TGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHL 300

Query: 301  SSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVN 360
            SSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVN
Sbjct: 301  SSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVN 360

Query: 361  RLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEK 420
            RLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEK
Sbjct: 361  RLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEK 420

Query: 421  GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGK 480
            GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGK
Sbjct: 421  GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGK 480

Query: 481  PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDP 540
            PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDP
Sbjct: 481  PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDP 540

Query: 541  EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV 600
            EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV
Sbjct: 541  EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV 600

Query: 601  GDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMP 660
            GDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMP
Sbjct: 601  GDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMP 660

Query: 661  IDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLP 720
            IDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLP
Sbjct: 661  IDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLP 720

Query: 721  GLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEA 780
            GLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEA
Sbjct: 721  GLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEA 780

Query: 781  PQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAE 840
            PQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAE
Sbjct: 781  PQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAE 840

Query: 841  GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900
            GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE
Sbjct: 841  GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900

Query: 901  KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME 960
            KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME
Sbjct: 901  KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME 960

Query: 961  DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK 1020
            DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK
Sbjct: 961  DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK 1020

Query: 1021 EAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEV 1080
            EAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEV
Sbjct: 1021 EAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEV 1080

Query: 1081 TRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDN 1140
            TRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDN
Sbjct: 1081 TRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDN 1140

Query: 1141 PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRE 1200
            PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRE
Sbjct: 1141 PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRE 1200

Query: 1201 NRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEG 1260
            NRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEG
Sbjct: 1201 NRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEG 1260

Query: 1261 QGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDM 1320
            QGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDM
Sbjct: 1261 QGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDM 1320

Query: 1321 EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSD 1380
            EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSD
Sbjct: 1321 EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSD 1380

Query: 1381 VAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERK 1440
            VAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERK
Sbjct: 1381 VAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERK 1440

Query: 1441 TSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVK 1500
            TSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVK
Sbjct: 1441 TSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVK 1500

Query: 1501 PDFTETREKQQHMVQGESETADVSPNNMQV 1530
            PDFTETREKQQHMVQGESETADVSPNNMQV
Sbjct: 1501 PDFTETREKQQHMVQGESETADVSPNNMQV 1530


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score =  116 bits (291), Expect = 1e-25
 Identities = 262/1182 (22%), Positives = 460/1182 (38%), Gaps = 194/1182 (16%)

Query: 415  EKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAK------FSAQEIKT--GLK 466
            E   E+  E ++A   + +  E  + +  +++E K     +         +E KT  GL+
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332

Query: 467  EVVTAVEEMTSKGKPGQEV----LEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA--- 519
            E    +EE       GQ+     LE+ +E   +   EE  +++E K+G +   +G+A   
Sbjct: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392

Query: 520  DVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKT 579
             ++  G+P+      + ++  ++ SE SS   PD + + +D+        ++E++    +
Sbjct: 1393 GLKEEGLPE------EGSVHGQELSEASS---PDGKGSQEDD-------PVQEEEAGRAS 1436

Query: 580  ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEES 639
            AS+    +      +E  S + +    TD S  E  R+S SQ     +KP  + +  +E 
Sbjct: 1437 ASAEPCPAEGTEEPTEPPSHLSE----TDPSASE--RQSGSQLEPGLEKPPGATMMGQEH 1490

Query: 640  LEIEIED--QEITKADVETKPMPIDESFENVLKEGTEKG-----TQEIAE-----GLSEK 687
             + +      E + +   +  +  D  + +VL + TEK         +AE     GL + 
Sbjct: 1491 TQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDN 1550

Query: 688  SGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPG--LEEGGKDSLPLAYVL--------- 736
                  A E ++D ++  ++ST +   K  G  G  + E  +++L    +L         
Sbjct: 1551 DLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRL 1610

Query: 737  ------------ALGAPTMNFMVDETAAINSNKESQQ---------------LVQKTYTL 769
                         LG   ++F +++  A+++   SQ                + +K   +
Sbjct: 1611 RGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPM 1670

Query: 770  EKKEAMEEDEAPQHRDAD---IVQGKGEAALWGEA-----GAVHEAPLRAWKPTAEQPEL 821
              K  M     P     D   I+Q K      GEA     G  H  P         +  L
Sbjct: 1671 SPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGL 1730

Query: 822  AEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQAL 881
                ++     PG++ G +G    EG +RL       +G+A   DA+   + E     + 
Sbjct: 1731 GPGLSQ----GPGVDEGEDG----EGSQRLNRDKDPKLGEAEG-DAMAQER-EGKTHNSE 1780

Query: 882  MLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD 941
                 E  +A  EGE   E+     + +        E AA  +    +   AEG  A   
Sbjct: 1781 TSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEA 1840

Query: 942  VGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP----- 996
             GE++ E+          E   +   +G  +   G  +P  E  E    E    P     
Sbjct: 1841 EGEAQPES----------EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDV 1890

Query: 997  FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
             T EAE      SEG+ E     KEA    E VE  E  TE E   E +  E    E + 
Sbjct: 1891 ETPEAEWEVQPESEGA-EAPEAEKEAQPETESVEALE--TEGEDEPESEGAEAQEAE-EA 1946

Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETK 1116
            A+E     +P++ + ++    EE    +  +D +A + E + +  EGE + E    E+ +
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPES--EDVEALEVEVETQEAEGEAQPE---SEDVE 2001

Query: 1117 APPNE-MGSDAENEAPVEASELSDNPGLLGEDSLK---ETVVPIFEA--------TPGFE 1164
            AP  E    +AE EA  E+  +   P   GE++ +   ET     +A         P  E
Sbjct: 2002 APEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE 2061

Query: 1165 KSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALK----EGHRQDGEGALAAPE 1220
            +  +      +E  GE   E+ D + ++ E  +  E+  ++    EG  Q  EG + APE
Sbjct: 2062 EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEG-IEAPE 2120

Query: 1221 AEPAGK-----VQAPEGLIPATGQAEELAAKDHDSCA-----GLEGR-AEGQG-----GV 1264
             E   +     ++APE    A  ++E + A+D +  A     G+E + AE +      GV
Sbjct: 2121 TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGV 2180

Query: 1265 DVVLRTQEAVAEEDPIMAEKFREEAVD-----EDPEEEEDKECTLETEAMQDRNSEGDGD 1319
            +      EA  E + I A +   EA       E PE EE  E   E E ++   +EG+  
Sbjct: 2181 EAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEE--EAQPEPEGVETPEAEGEAQ 2238

Query: 1320 MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREV---------LAGSETAEEK- 1369
             E EG TQ      G +  + +V  G G++ E +     V           G +T  ++ 
Sbjct: 2239 PESEGETQ------GEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRP 2292

Query: 1370 -----TIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVT 1424
                   +++ASS+ +  ++++  + D ++G T +             +      E + +
Sbjct: 2293 GSQTGPSSSRASSWGNCWQKDS--ENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTS 2350

Query: 1425 YTTEAGVG--TPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
               EA +G  TP     +   L ++Q  GS     A G  DG
Sbjct: 2351 EQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADG 2392



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 236/1049 (22%), Positives = 377/1049 (35%), Gaps = 190/1049 (18%)

Query: 609  SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENV 668
            ++ ++ A R S ++ + ++  + +   ++E +++E E +E T+ +       + E    +
Sbjct: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLE-ETKEGTEGE------GLQEEAVQL 1322

Query: 669  LKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWE----------ESTAQVKDKKAG 718
             +  TE+G QE  EG+  +  K    E +++++++L E          E   Q+++ K G
Sbjct: 1323 EETKTEEGLQE--EGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG 1380

Query: 719  LPG------LEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKK 772
              G      LEEG K+          G P       E  +++  + S+       +    
Sbjct: 1381 PEGGLQGEALEEGLKEE---------GLP-------EEGSVHGQELSEA------SSPDG 1418

Query: 773  EAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAP--LRAWKPTAEQPELAEEFTEKRE 830
            +  +ED+  Q  +A       E           E P  L    P+A + +   +     E
Sbjct: 1419 KGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLE 1478

Query: 831  IPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKD------AVGLSKDEAPEKQALMLT 884
             PPG     +   +A+  +   E  S  +  +AA D      +V L K E      L   
Sbjct: 1479 KPPGATMMGQEHTQAQPTQGAAERSSS-VACSAALDCDPIWVSVLLKKTEKAFLAHLASA 1537

Query: 885  VLET------------DKAASEGEQGLEKAV--------------------------LAN 906
            V E             D+ A+E +Q + + +                          L  
Sbjct: 1538 VAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTG 1597

Query: 907  EAAALNLEHLHEVAALREAA--------------TSEEGEAEGGVAVSDVGESEE----- 947
            E      +  H +  LR  +              T E+  A      S +GE  E     
Sbjct: 1598 ELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFC 1657

Query: 948  --EASIDLEDTGPMEDTASK-------REDGSEEAILG---GEEPAKERKEVMRTETRLS 995
              EA +  +   PM   A+        +E    + IL    GE    E  EV   +T   
Sbjct: 1658 PCEACVR-KKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTD 1716

Query: 996  PFT-----------GEAEASRMQVSEGSPEEGS--LAKEAFLCKEDVEGEEMVTEAEANR 1042
            P +           G   +    V EG   EGS  L ++      + EG+ M  E E   
Sbjct: 1717 PTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKT 1776

Query: 1043 EDDRKEILPKELDLARERRK--AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKA 1100
             +        EL  A +  +  +ER +T  + +  E      A A  D+D  + +     
Sbjct: 1777 HNSETSA-GSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI 1835

Query: 1101 EEGETETEVRAEEETKAPPNEMGS--DAENEAPVEASELSDNPGLLGEDSLKETVVPIFE 1158
            E  E E E + E E    P   G   +AE EA  E+ ++ + P   GE   +   V   E
Sbjct: 1836 EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDV-EAPEAEGEAQPESEDVETPE 1894

Query: 1159 ATPGFEKSLENITA--LRKEGGGERLS-EARDTEHKDREELSSRENRALKEGHRQDGEGA 1215
            A    +   E   A    KE   E  S EA +TE +D  E    E +  +E         
Sbjct: 1895 AEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEE--------- 1945

Query: 1216 LAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVA 1275
             AA EAE  G+ Q PE  +  + +AEE A  + +    LE          V + TQEA  
Sbjct: 1946 -AAQEAE--GQTQ-PESEVIESQEAEEEAQPESEDVEALE----------VEVETQEAEG 1991

Query: 1276 EEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGG 1335
            E  P   +    EA  E  E EE+ +   +    Q + SEG+   E EG TQK EG    
Sbjct: 1992 EAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK-SEGEEAQEVEGETQKTEGDAQP 2050

Query: 1336 RVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVG 1395
                VE      E  E   E +E    +    E   A +A    +   E    +  E  G
Sbjct: 2051 ESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAE--GEAQPESEGVEAPEAEG 2108

Query: 1396 KTAAAGKVVVEELARSGEEVPAAEEMTVTYTT-EAGVGTPGALERKTSGLGQEQEEGSEG 1454
            +   A  +   E    GE  P +E +       EA   + G   +   G  Q + EG E 
Sbjct: 2109 EAQKAEGIEAPE--TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEA 2166

Query: 1455 QEAATGSG------DGRQETGAAEKFRLGL-SREGERELSP-----ESLQAMATLPVKPD 1502
            QEA   +       +  +  G A+    G+ + E E E  P     E+ +A      +P+
Sbjct: 2167 QEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE 2226

Query: 1503 FTETREKQ-QHMVQGESETADVSPNNMQV 1530
              ET E + +   + E ET      + QV
Sbjct: 2227 GVETPEAEGEAQPESEGETQGEKKGSPQV 2255



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 154/704 (21%), Positives = 253/704 (35%), Gaps = 138/704 (19%)

Query: 419  EKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSK 478
            +K  +L +AEG    +           +E KT  S   +  E    L E     E ++ +
Sbjct: 1755 DKDPKLGEAEGDAMAQE----------REGKTHNSETSAGSE----LGEAEQEGEGISER 1800

Query: 479  GKPGQEVL--EDDQENTLKYEYEEDFEVDEEKQGEKSNE-EGQADVQMNGIPQSPLDDKK 535
            G+ G +    ED+ +       ++D    +  +G ++ E EG+A  +  G+     +   
Sbjct: 1801 GETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDA 1860

Query: 536  DNLDPEKESETSSQKAPDARDNVKDENDGCS----------ESELEEDKQDMKTASSTSS 585
               + E + E+   +AP+A    + E++             ESE  E  +  K A   + 
Sbjct: 1861 QEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETE 1920

Query: 586  RSHPYSSDSEDESAVGDREA--------HTDSSTDESARRSSSQELSENDKPRKSHLPIE 637
                  ++ EDE      EA          +  T   +    SQE  E  +P    +   
Sbjct: 1921 SVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV--- 1977

Query: 638  ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697
            E+LE+E+E QE      E +  P  E  E    EG  +  +E  E   E  G     + +
Sbjct: 1978 EALEVEVETQE-----AEGEAQPESEDVEAPEAEGEMQEAEE--EAQPESDGVEAQPKSE 2030

Query: 698  EKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNK 757
             ++  ++  E+     D +    G+E                            A  + +
Sbjct: 2031 GEEAQEVEGETQKTEGDAQPESDGVE----------------------------APEAEE 2062

Query: 758  ESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTA- 816
            E+Q+        E +EA E +  P+  D D  + +GEA    E     EA   A K    
Sbjct: 2063 EAQEAEG-----EVQEA-EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI 2116

Query: 817  EQPELAEEFTEKREIPPGIERGAEGAAEAEGVR-RLGEGGSDPIGQA---------AAKD 866
            E PE   E   + E     E   E   E+EGV  +  EG + P  +          A  +
Sbjct: 2117 EAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPE 2176

Query: 867  AVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE--KAVLANEAAALNLEHLHEVAALRE 924
              G+   EA  +       +E  +A  E +  LE  +A  A E A    E +    A  E
Sbjct: 2177 LEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236

Query: 925  AATSEEGEAEG------GVAVSDVGESEE--EASIDLED--------------------- 955
            A    EGE +G       V++ D G+SEE  E+S  + +                     
Sbjct: 2237 AQPESEGETQGEKKGSPQVSLGD-GQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQ 2295

Query: 956  TGPMEDTASK-----REDGSEEAILGGEEPAKERK----EVMRTETRLSPFTGEAEASRM 1006
            TGP    AS      ++D   + +LG       +        R  TR+ P +  +E    
Sbjct: 2296 TGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEA 2355

Query: 1007 QVSEGSPEEGSLAKEAFLCKED-----VEGEEMVTEAEANREDD 1045
             +   +PE+G  A E +  +ED     +   E V  A+   +DD
Sbjct: 2356 PLGSRTPEQG--ASEGYDLQEDQALGSLAPTEAVGRADGFGQDD 2397



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 174/885 (19%), Positives = 313/885 (35%), Gaps = 132/885 (14%)

Query: 399  IAMGLDKKPSLPKSRKEKSTEK--GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKF 456
            ++  L+ +P+L  +   +  E+  GEE    E  VRK+   + PK   +   +  +   F
Sbjct: 1629 LSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKAT-MGATRGPIKEAF 1687

Query: 457  SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEE 516
              Q+I    +   T  E   ++  PG+   +     T++           +  G    E+
Sbjct: 1688 DLQQILQRKRGEHTDGE--AAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745

Query: 517  GQADVQMNGIPQSPLDDKK-DNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQ 575
            G+   ++N      L + + D +  E+E +T + +           + G    E E++ +
Sbjct: 1746 GEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSET----------SAGSELGEAEQEGE 1795

Query: 576  DMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLP 635
             +     T  +   +  + + E+A G          D+   +S   E  E  +      P
Sbjct: 1796 GISERGETGGQGSGHEDNLQGEAAAGG---------DQDPGQSDGAEGIEAPEAEGEAQP 1846

Query: 636  IEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAE 695
              E +E    + +  +A+ E +P   D        E  E      AEG ++   + V   
Sbjct: 1847 ESEGVEAPEAEGDAQEAEGEAQPESEDV-------EAPE------AEGEAQPESEDVETP 1893

Query: 696  EKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINS 755
            E E      WE    Q + + A  P   E  K++ P                +   A+ +
Sbjct: 1894 EAE------WE---VQPESEGAEAP---EAEKEAQP--------------ETESVEALET 1927

Query: 756  NKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPT 815
              E +   +     E +EA +E E     ++++++ +          A  EA     +P 
Sbjct: 1928 EGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE---------AEEEA-----QPE 1973

Query: 816  AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKD-E 874
            +E  E  E   E +E        AEG A+ E                        S+D E
Sbjct: 1974 SEDVEALEVEVETQE--------AEGEAQPE------------------------SEDVE 2001

Query: 875  APEKQALMLTVLETDKAASEGEQGLEKAV--LANEAAALNLEHLHEVAALREAATSEEGE 932
            APE +  M    E  +  S+G +   K+    A E      +   +     +   + E E
Sbjct: 2002 APEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE 2061

Query: 933  AEGGVAVSDVGESEEEASIDLEDTGPME--DTASKREDGSEEAILGGEEPAKERKEVMRT 990
             E   A  +V E+E EA  + ED    E    A    +G E     GE    E  E   T
Sbjct: 2062 EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPET 2121

Query: 991  ETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEIL 1050
            E    P   E+E      +EG  +  S   EA   + + + E    EA+   E+ + E+ 
Sbjct: 2122 EGEAQP---ESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPEL- 2177

Query: 1051 PKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLK--AEEGETETE 1108
             + ++      +A+     +   ++E E       ++  +A +E Q      E  E E E
Sbjct: 2178 -EGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236

Query: 1109 VRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLE 1168
             + E E +    + GS   +    ++ E S++   + ED       P  +       S  
Sbjct: 2237 AQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQT 2296

Query: 1169 NITALRKEGGGERLSEARDTEH-----KDREELSSRENRALKEGHRQDGEGALAAPEAEP 1223
              ++ R    G    +  + +H     +  +  S+    A ++  R   E + +  E  P
Sbjct: 2297 GPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAP 2356

Query: 1224 AGKVQAPEGLIPATGQAEELAAKDHDSCAGLE--GRAEGQGGVDV 1266
             G     +G        E+ A     S A  E  GRA+G G  D+
Sbjct: 2357 LGSRTPEQGASEGYDLQEDQAL---GSLAPTEAVGRADGFGQDDL 2398


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score =  103 bits (256), Expect = 2e-21
 Identities = 154/624 (24%), Positives = 240/624 (38%), Gaps = 76/624 (12%)

Query: 877  EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEG- 935
            EK   +  V +  K  + GE   + A+  N+ +    +   E++ ++E    ++  ++G 
Sbjct: 512  EKSLKLSPVQKQKKQQTIGELTQDTALTENDDS----DEYEEMSEMKEGKACKQHVSQGI 567

Query: 936  ---GVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKE---RKEVMR 989
                 A +    S+EE  I  E  G  +   SK     E+ +   EE  K    RKE  +
Sbjct: 568  FMTQPATTIEAFSDEEVEIPEEKEGAED---SKGNGIEEQEVEANEENVKVHGGRKE--K 622

Query: 990  TETRLSPFTGEAEASRMQV-SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKE 1048
            TE      T +AE S  +  S G  E+G   +    C+E   G E   + E  RE   K+
Sbjct: 623  TEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEE--REKGEKD 680

Query: 1049 ILPKELDLARERRKAERPKTSLRKTDSE------REEVTRANALKDEDAFKEEQKLKAEE 1102
                E++   E  K    K   +K D E      RE+  +    ++ +   EE+  + EE
Sbjct: 681  KGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEE 740

Query: 1103 GETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPG 1162
             E + E   E+E +      G + E E   E  E         E+  +E      +   G
Sbjct: 741  EEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEG----DQGEG 796

Query: 1163 FEKSLENITALRKEGG---GERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAP 1219
             E+  E     ++EGG   G  + E +    ++ EE    E     EG  ++GEG     
Sbjct: 797  EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG--EGEEEEGEGE--EE 852

Query: 1220 EAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAE-ED 1278
            E E  G+ +  EG     G+  E   ++ +     E   EG+G        +E   E E+
Sbjct: 853  EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEG------EEEEGEGEGEE 906

Query: 1279 PIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD---MEGEGNTQKNEGMGGG 1335
                E   EE   +  EE E+ E   E E  +    +G+G+    EGE   ++ EG G G
Sbjct: 907  EGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEG 966

Query: 1336 RVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVG 1395
                 E   G GE  E   EE E   G    EE+    +     +  EE     ++E  G
Sbjct: 967  E----EEGEGEGEEGEGEGEEEE---GEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEG 1019

Query: 1396 KTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQE------QE 1449
            +    G+V  EE    GEE    EE                 ER+  G G+E      +E
Sbjct: 1020 EVE--GEVEGEEGEGEGEEEEGEEE---------------GEEREKEGEGEENRRNREEE 1062

Query: 1450 EGSEGQEAATGSGDGRQETGAAEK 1473
            E  EG+   TG  +  ++ G   K
Sbjct: 1063 EEEEGKYQETGEEENERQDGEEYK 1086



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 155/637 (24%), Positives = 240/637 (37%), Gaps = 59/637 (9%)

Query: 735  VLALGAPTMNFMVDETAAINSNKESQQL--VQKTYTLEKKEAMEEDEA-PQHRDADIVQG 791
            V +LG  T    +    ++NSN++S +L  VQK    +    + +D A  ++ D+D  + 
Sbjct: 490  VESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEE 549

Query: 792  KGEAALWGEAGAVHEAP-LRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRR 850
              E    G+A   H +  +   +P       ++E  E  E   G E       E + V  
Sbjct: 550  MSEMKE-GKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEA 608

Query: 851  LGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAA 910
              E      G+   K+   +  D+  +K  +     ++   A +G +G        E  +
Sbjct: 609  NEENVKVHGGR---KEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTC--EEGS 663

Query: 911  LNLEHLHEVAALREAATSEEGEAE---GGVAVSDVGESEEEASIDLEDTGPMEDTASKRE 967
               EH  +    RE    ++G  E    G    ++ E EE    D E+    E     ++
Sbjct: 664  SGAEHWQDEE--REKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQK 721

Query: 968  DGSEEAILGGEEP--AKERKEVMRTETRLSPFTGEAEASRMQVS-EGSPEEGSLAKEAFL 1024
            + ++E   GGEE     E +E  R E       G+ E    +V  E   EEG   KE   
Sbjct: 722  ERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERA 781

Query: 1025 CKEDV--------EGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSE 1076
             KE+         EGEE  TE     +++  E+   E++  +  R+ E  +    + + E
Sbjct: 782  GKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE 841

Query: 1077 REEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASE 1136
             EE       ++E   K E++ +  EGE E E   E E +    E   + E E   E  E
Sbjct: 842  GEE-EEGEGEEEEGEGKGEEEGEEGEGEEEGE---EGEGEGEEEEGEGEGEEEGEGEGEE 897

Query: 1137 LSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREEL 1196
                    GE   +E      E   G  K  E      +EG GE   E  + E +D E  
Sbjct: 898  EE------GEGEGEEEGEGEGEEEEGEGKGEEE----GEEGEGEGEEEEGEGEGEDGEG- 946

Query: 1197 SSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEG 1256
               E     EG  ++GEG     E E  G+ +  EG     G+ EE   +  +     EG
Sbjct: 947  EGEEEEGEWEGEEEEGEG-----EGEEEGEGEGEEG--EGEGEEEEGEGEGEEEEGEEEG 999

Query: 1257 RAEGQG-----GVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQD 1311
              EG+G     G        E   E +    E   EE   E+  EE +KE   E      
Sbjct: 1000 EEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENR--- 1056

Query: 1312 RNSEGDGDMEG---EGNTQKNEGMGGGRVVAVEVLHG 1345
            RN E + + EG   E   ++NE   G     V  + G
Sbjct: 1057 RNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKG 1093



 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 168/701 (23%), Positives = 259/701 (36%), Gaps = 130/701 (18%)

Query: 491  ENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQK 550
            EN    EYEE  E+ E K  ++   +G    Q       P    +   D E E     + 
Sbjct: 540  ENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQ-------PATTIEAFSDEEVEIPEEKEG 592

Query: 551  APDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDES--------AVGD 602
            A D++ N      G  E E+E +++++K       ++   S D  D++        +VG+
Sbjct: 593  AEDSKGN------GIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGE 646

Query: 603  REAHTDSSTDESARRSSS---------QELSENDKPR-KSHLPIEESLEIEIEDQEITKA 652
             E   +   D +    SS         +E  E DK R +   P E   E+  E +E  K 
Sbjct: 647  AEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELA-EKEEWKKR 705

Query: 653  DVETKPMPIDESFENVLKEGTEKG-TQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQ 711
            D E       E  +   ++G +K   QE+ EG  E+ G+    EE+E D+ +        
Sbjct: 706  DGE-------EQEQKEREQGHQKERNQEMEEGGEEEHGE---GEEEEGDREE-------- 747

Query: 712  VKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEK 771
             +++K G  G EEG                       E   +   +E ++  +K      
Sbjct: 748  -EEEKEG-EGKEEG-----------------------EGEEVEGEREKEEGERKKEERAG 782

Query: 772  KEAMEEDEAPQHR-DADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKRE 830
            KE   E+E  Q   + +  +G+GE     E G V    +   K   E+ E  EE   + E
Sbjct: 783  KEEKGEEEGDQGEGEEEETEGRGEEK--EEGGEVEGGEVEEGKGEREEEE--EEGEGEEE 838

Query: 831  IPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDK 890
               G E   EG  E EG  +  E G +  G+   ++  G  ++E  E +       E ++
Sbjct: 839  EGEGEEEEGEGEEE-EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEE 897

Query: 891  AASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD-VGESEEEA 949
               EGE G E+     E                     EEGE +G     +  GE EEE 
Sbjct: 898  EEGEGE-GEEEGEGEGE--------------------EEEGEGKGEEEGEEGEGEGEEEE 936

Query: 950  SIDLEDTGPMEDTASKRE----------DGSEEAILGGEEPAKERKEVM---RTETRLSP 996
                 + G  E    + E          +G EE    GEE   E +E       E     
Sbjct: 937  GEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE 996

Query: 997  FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
              GE E    +  EG  EE    +E    + +VEGEE   E E    ++  E   KE + 
Sbjct: 997  EEGEEEGEGEEEGEGEGEE----EEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052

Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETK 1116
               RR  E  +    K     EE    N  +D + +K+  K+K   G  +       + K
Sbjct: 1053 EENRRNREEEEEEEGKYQETGEE---ENERQDGEEYKKVSKIK---GSVKYGKHKTYQKK 1106

Query: 1117 APPNEMGSDAE--NEAPVEASELSDNPGLLGEDSLKETVVP 1155
            +  N  G+  E  ++ PV++  L  N G  G       V+P
Sbjct: 1107 SVTNTQGNGKEQRSKMPVQSKRLLKN-GPSGSKKFWNNVLP 1146



 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 118/477 (24%), Positives = 182/477 (38%), Gaps = 96/477 (20%)

Query: 1014 EEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT 1073
            EE S  KE   CK+ V     +T+     E    E    E+++  E+  AE  K      
Sbjct: 548  EEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDE----EVEIPEEKEGAEDSK------ 597

Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETE-TEVRAEEET-KAPPNEMGSDAENEAP 1131
                      N +++++    E+ +K   G  E TE+ +++ T KA  +E  + +  EA 
Sbjct: 598  ---------GNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEA- 647

Query: 1132 VEASELSDNPGLLGEDSLKETVVPIFEATPGFE--KSLENITALRKEGGGERLSEAR-DT 1188
                   D P   G+ + +E        + G E  +  E     + +G GE       + 
Sbjct: 648  ------EDGPEGRGDGTCEE-------GSSGAEHWQDEEREKGEKDKGRGEMERPGEGEK 694

Query: 1189 EHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDH 1248
            E  ++EE   R+    ++  R+ G       E E  G+ +  EG      + EE   ++ 
Sbjct: 695  ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEG------EEEEGDREEE 748

Query: 1249 DSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEA 1308
            +   G EG+ EG+G                        EE   E   E+E+ E   E  A
Sbjct: 749  EEKEG-EGKEEGEG------------------------EEV--EGEREKEEGERKKEERA 781

Query: 1309 MQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEE 1368
             ++   E +GD +GEG  ++ EG G  +    EV   GGE  E   E  E     E  EE
Sbjct: 782  GKEEKGEEEGD-QGEGEEEETEGRGEEKEEGGEV--EGGEVEEGKGEREEEEEEGEGEEE 838

Query: 1369 KTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTE 1428
            +          +  EEE   +++E  GK         EE    GE     EE       E
Sbjct: 839  E---------GEGEEEEGEGEEEEGEGKG--------EEEGEEGEGEEEGEEGEGEGEEE 881

Query: 1429 AGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERE 1485
             G G     E +  G G+ +EE  EG+    G G+G +E G  +    G   EGE E
Sbjct: 882  EGEG-----EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGE 933



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 132/636 (20%), Positives = 222/636 (34%), Gaps = 138/636 (21%)

Query: 404  DKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKT 463
            D++  +P+ ++     KG  +++ E +  +E   V   R E    KT + +     +  T
Sbjct: 581  DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKE----KTEILS-----DDLT 631

Query: 464  GLKEVVTAVEEMTSKGKPGQEVLEDD--QENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
               EV     +   + + G E   D   +E +   E+ +D   +E ++GEK  ++G+ ++
Sbjct: 632  DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQD---EEREKGEK--DKGRGEM 686

Query: 522  QMNGIPQSPLDDKKD--NLDPEKESETSSQKAPDARDNVKDENDGCSE-SELEEDKQDMK 578
            +  G  +  L +K++    D E++ +   ++      N + E  G  E  E EE++ D +
Sbjct: 687  ERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDRE 746

Query: 579  TASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEE 638
                          + E E   G+RE        E       +   E D+        E 
Sbjct: 747  EEEEKEGEG---KEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEG 803

Query: 639  SLEIEIEDQEITKADVET-KPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697
              E + E  E+   +VE  K    +E  E   +E   +G +E  EG  E+       E +
Sbjct: 804  RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE 863

Query: 698  EKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNK 757
            E +  +  EE   + ++++    G EEG  +                             
Sbjct: 864  EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEG---------------------------- 895

Query: 758  ESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAE 817
                        E++E   E E     + +  +G+G+    GE G               
Sbjct: 896  ------------EEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE------------ 931

Query: 818  QPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPE 877
                 EE   + E   G   G E   E EG    GEG  +  G+   ++  G  ++E  E
Sbjct: 932  ----GEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE 987

Query: 878  KQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGV 937
             +       E ++   EGE+                          E    EEGE E   
Sbjct: 988  GEG------EEEEGEEEGEE--------------------------EGEGEEEGEGE--- 1012

Query: 938  AVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPF 997
                 GE EEE  ++ E  G   +   + E+G EE    GEE  KE              
Sbjct: 1013 -----GEEEEEGEVEGEVEGEEGEGEGEEEEGEEE----GEEREKE-------------- 1049

Query: 998  TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEE 1033
             GE E +R    E   EEG   +      E  +GEE
Sbjct: 1050 -GEGEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084



 Score = 35.4 bits (80), Expect = 0.43
 Identities = 35/165 (21%), Positives = 69/165 (41%), Gaps = 21/165 (12%)

Query: 473  EEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLD 532
            EE   +G+  +E  E++ E   + E E + E +EE++GE   E    + +  G  +   +
Sbjct: 982  EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEE---E 1038

Query: 533  DKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSS 592
             +++  + EKE E              +EN    E E EE+ +  +T    + R      
Sbjct: 1039 GEEEGEEREKEGE-------------GEENRRNREEEEEEEGKYQETGEEENER-----Q 1080

Query: 593  DSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIE 637
            D E+   V   +        ++ ++ S      N K ++S +P++
Sbjct: 1081 DGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQ 1125



 Score = 33.1 bits (74), Expect = 2.1
 Identities = 56/250 (22%), Positives = 93/250 (37%), Gaps = 31/250 (12%)

Query: 1280 IMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVA 1339
            IM+    E+++   P +++ K+ T+         +E D   E E  ++  EG    + V+
Sbjct: 505  IMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVS 564

Query: 1340 VEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAA 1399
              +      T   A  + EV    E  EEK  A + S  + + E+E    ++ +  K   
Sbjct: 565  QGIFMTQPATTIEAFSDEEV----EIPEEKEGA-EDSKGNGIEEQEVEANEENV--KVHG 617

Query: 1400 AGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGT----PGALERKTSGLGQEQEEGSEGQ 1455
              K   E L+    +     E       EA  G      G  E  +SG    Q+E  E  
Sbjct: 618  GRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKG 677

Query: 1456 EAATG------SGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTETREK 1509
            E   G       G+G +E    E+++    R+GE +   E  Q              +E+
Sbjct: 678  EKDKGRGEMERPGEGEKELAEKEEWK---KRDGEEQEQKEREQG-----------HQKER 723

Query: 1510 QQHMVQGESE 1519
             Q M +G  E
Sbjct: 724  NQEMEEGGEE 733


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 170/833 (20%), Positives = 323/833 (38%), Gaps = 123/833 (14%)

Query: 405  KKPSLPKSRKEKSTEK-----GEELKKAEGKVRKEREYVIPKRNEIKENKTSV--SAKFS 457
            +K  L K ++  S EK       + K+ E K+ K++   + ++  + E K  +    K  
Sbjct: 1169 EKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIR 1228

Query: 458  AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517
            ++E K  L+E     E+     +      E+ + + LK + +   E  E +   K+ +EG
Sbjct: 1229 SEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEG 1288

Query: 518  -QADVQMNGIP----------------------QSPLDDKKDNLDPEKE--------SET 546
             Q   +M G+P                      Q P   K D ++P KE        S+T
Sbjct: 1289 KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDT 1348

Query: 547  SSQKAPDARDNVKD---ENDGCSESELE-------EDKQDMK-----TASSTSSRSHPYS 591
            SS + P +   + D    +DG S S  E       ++K  +K     + S  SS S P  
Sbjct: 1349 SSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSD 1408

Query: 592  SDSEDESAVGDREAHTDSSTDE-SARRSSSQELS-ENDKPRKSHLPIEESLEIEIEDQEI 649
                + + +   EA   +  DE S +++   E+S E  K ++    + E+LEI I ++EI
Sbjct: 1409 LAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEI 1468

Query: 650  TKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEE----------KEK 699
             ++  E K     +S +++      K   E  + ++ +   + S EE          + K
Sbjct: 1469 KESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRK 1528

Query: 700  DKSKLWEESTAQVKDKKAGLPGLEEG--GKDSLPL-AYVLALGAPTMNFMVDETAAINSN 756
             ++ +   S+ + K + +   G EE    K  + + A   A G+    F+ ++   I+S+
Sbjct: 1529 RRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSS 1588

Query: 757  KESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTA 816
             ESQ+        E+ +   +  A +HR    +  K   ++  +AG  H       +   
Sbjct: 1589 TESQK-------KEETKGKGKITAGKHRR---LTRKSSTSIDEDAGRRHSWHDEDDEAFD 1638

Query: 817  EQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP 876
            E PEL    T+ +E    +  G  G    + +  L    +D     +++    L  DE P
Sbjct: 1639 ESPELKYRETKSQESEELVVTGGGGLRRFKTI-ELNSTIADKYSAESSQKKTSLYFDEEP 1697

Query: 877  EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGG 936
            E +   LT    D++  EG   L  +      +  +      V++L E + S     +  
Sbjct: 1698 ELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTS------VSSLDEDSDSSPSHKK-- 1749

Query: 937  VAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP 996
                  GES+++        GP+  T    ED SE      EE  +E +E+++ + +   
Sbjct: 1750 ------GESKQQRKARHRPHGPLLPTI---EDSSE------EEELREEEELLKEQEKQRE 1794

Query: 997  FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
               +   S  + S+   +E    +     K        + +A    E      L +  ++
Sbjct: 1795 IEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEE------LRQAAEM 1848

Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFK-----------EEQKLKAEEGET 1105
                R +    +   ++D E  E++    ++ +  +K           +EQ +  +EG  
Sbjct: 1849 EELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQ 1908

Query: 1106 ETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNP----GLLGEDSLKETVV 1154
            +    AEE  +   ++        A  E  E+ +      G+L ED + E++V
Sbjct: 1909 KALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLV 1961



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 159/817 (19%), Positives = 312/817 (38%), Gaps = 124/817 (15%)

Query: 429  GKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKP-GQEVLE 487
            G +RK    + P  +  K +   V  + S+Q  KT +   V  V++   + K   ++V+ 
Sbjct: 1120 GDIRK----MPPAPSGPKASPMPVPTESSSQ--KTAVPPQVKLVKKQEQEVKTEAEKVIL 1173

Query: 488  DDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETS 547
            +  + TL  E        ++KQ E   E+ +A        + PL ++K  L PE+E   S
Sbjct: 1174 EKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQE---KKPLPEEK-KLIPEEEKIRS 1229

Query: 548  SQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHT 607
             +K P   +          +    EDK+ +  A +++     +             ++  
Sbjct: 1230 EEKKPLLEE----------KKPTPEDKKLLPEAKTSAPEEQKHDL----------LKSQV 1269

Query: 608  DSSTDESARRSSSQELSENDKP--RKSHLPIEESLEIEIEDQEITKADVETKPMPIDESF 665
              + ++   R + + + E  +P  +   LP      +  ED + TK  ++ +P P   + 
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKT-IKEQPQPPCTAK 1328

Query: 666  ENVLKEGTEKGTQE-----IAEGLSEKSGKHVSAEEKEKD--KSKLWEESTAQVKDKKAG 718
             + ++ G EK  +E      +     KS + +S      D   S L E  +    D+K  
Sbjct: 1329 PDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDI 1388

Query: 719  LPGLEEGG--KDSLPLAYV-LALGAPTMNFMVDETAAINSNKESQQLVQ-------KTYT 768
            L GL++    ++S P +   LA    T+  +++  A+  ++++S++  Q       +   
Sbjct: 1389 LKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKD 1448

Query: 769  LEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEK 828
             EK +++ E       + +I + + E     +  +  + P  + K   E+ E  ++ T +
Sbjct: 1449 QEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIP--SSKDHKEKSEFVDDITTR 1506

Query: 829  REIPPGIERGAEGAAEAEGVRR----LGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLT 884
            RE    +E  +E        R+    +G   SD   Q   +D+ G  ++E   ++ ++  
Sbjct: 1507 REPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQ---EDSQGSGEEEDFIRKQIIEM 1563

Query: 885  VLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGE 944
              + D + SE ++ +                L E+++  E+   EE + +G +       
Sbjct: 1564 SADEDASGSEDDEFIRN-------------QLKEISSSTESQKKEETKGKGKITAGKHRR 1610

Query: 945  SEEEASIDLE-----------------DTGPMEDTASKREDGSEEAILGGEEPAKERKEV 987
               ++S  ++                 D  P       +   SEE ++ G    +  K +
Sbjct: 1611 LTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTI 1670

Query: 988  MRTETRLSPFTGEAEASR------------MQVSEGSPEEGSLAK-EAFLCKEDVEGEEM 1034
                T    ++ E+   +            M+    SPE+ S  +  + L          
Sbjct: 1671 ELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTS 1730

Query: 1035 VTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT--DSEREEVTRANALKDEDAF 1092
             T   +  ED       K+ +  ++R+   RP   L  T  DS  EE  R    ++E+  
Sbjct: 1731 PTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELR----EEEELL 1786

Query: 1093 KEEQKLKAEEGET-----------ETEVRAE---EETKAPPNEMGSDAENEAPVEASELS 1138
            KE++K +  E +            + E+RA+   E  K PP+ + S  E+ +P E    +
Sbjct: 1787 KEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNL-SPIEDASPTEELRQA 1845

Query: 1139 DNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRK 1175
                 L   S  E    I     GFE S E I  ++K
Sbjct: 1846 AEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQK 1882



 Score = 35.0 bits (79), Expect = 0.56
 Identities = 92/551 (16%), Positives = 198/551 (35%), Gaps = 89/551 (16%)

Query: 873  DEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGE 932
            + + +K A+   V    K   E +   EK +L      L++E +  +    +     + E
Sbjct: 1142 ESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLE 1201

Query: 933  AEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTET 992
             +   A+ +     EE  +  E+         K     ++ +L  ++P  E K+++    
Sbjct: 1202 KDKASALQEKKPLPEEKKLIPEE--------EKIRSEEKKPLLEEKKPTPEDKKLLPEAK 1253

Query: 993  RLSPFTGEAEASRMQVSEGSPE-EGSLA----KEAFLCKEDVEGEEMVTEAEANREDDRK 1047
              +P   + +  + QV     + EG +A    +E    +  +EG    T     +EDD+ 
Sbjct: 1254 TSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKT 1313

Query: 1048 EILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDE------DAFKEEQKLKAE 1101
                KE        K ++ +    KT+ E ++   +++ + +      D       + + 
Sbjct: 1314 TKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS 1373

Query: 1102 EGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSD-----------NPGLLGEDSLK 1150
             GE  + +  +E+      +  S ++  +P   S+L+                L ++  +
Sbjct: 1374 LGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSE 1433

Query: 1151 ETVVPIFEATPGFEKSLENITALRKEG----GGERLSEARDTEHKDREELSSRENRALKE 1206
            +   P  E +P   K  E   +L +        E + E+++ E KD  +  S+++    +
Sbjct: 1434 KKTQP-HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE-ERKDTFKKDSQQDIPSSK 1491

Query: 1207 GHRQDGEGAL-AAPEAEPAGKVQ----APEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261
             H++  E         EP   V+    +    +P   +   + +   D     + +  G 
Sbjct: 1492 DHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSG- 1550

Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDME 1321
                          EE+  + ++  E + DED    ED       E ++++  E     E
Sbjct: 1551 --------------EEEDFIRKQIIEMSADEDASGSED------DEFIRNQLKEISSSTE 1590

Query: 1322 GEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDV 1381
             +   +K E  G G++              TA + R +   S T+ ++          D 
Sbjct: 1591 SQ---KKEETKGKGKI--------------TAGKHRRLTRKSSTSIDE----------DA 1623

Query: 1382 AEEETWHQQDE 1392
                +WH +D+
Sbjct: 1624 GRRHSWHDEDD 1634


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 170/833 (20%), Positives = 323/833 (38%), Gaps = 123/833 (14%)

Query: 405  KKPSLPKSRKEKSTEK-----GEELKKAEGKVRKEREYVIPKRNEIKENKTSV--SAKFS 457
            +K  L K ++  S EK       + K+ E K+ K++   + ++  + E K  +    K  
Sbjct: 1169 EKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIR 1228

Query: 458  AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517
            ++E K  L+E     E+     +      E+ + + LK + +   E  E +   K+ +EG
Sbjct: 1229 SEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEG 1288

Query: 518  -QADVQMNGIP----------------------QSPLDDKKDNLDPEKE--------SET 546
             Q   +M G+P                      Q P   K D ++P KE        S+T
Sbjct: 1289 KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDT 1348

Query: 547  SSQKAPDARDNVKD---ENDGCSESELE-------EDKQDMK-----TASSTSSRSHPYS 591
            SS + P +   + D    +DG S S  E       ++K  +K     + S  SS S P  
Sbjct: 1349 SSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSD 1408

Query: 592  SDSEDESAVGDREAHTDSSTDE-SARRSSSQELS-ENDKPRKSHLPIEESLEIEIEDQEI 649
                + + +   EA   +  DE S +++   E+S E  K ++    + E+LEI I ++EI
Sbjct: 1409 LAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEI 1468

Query: 650  TKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEE----------KEK 699
             ++  E K     +S +++      K   E  + ++ +   + S EE          + K
Sbjct: 1469 KESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRK 1528

Query: 700  DKSKLWEESTAQVKDKKAGLPGLEEG--GKDSLPL-AYVLALGAPTMNFMVDETAAINSN 756
             ++ +   S+ + K + +   G EE    K  + + A   A G+    F+ ++   I+S+
Sbjct: 1529 RRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSS 1588

Query: 757  KESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTA 816
             ESQ+        E+ +   +  A +HR    +  K   ++  +AG  H       +   
Sbjct: 1589 TESQK-------KEETKGKGKITAGKHRR---LTRKSSTSIDEDAGRRHSWHDEDDEAFD 1638

Query: 817  EQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP 876
            E PEL    T+ +E    +  G  G    + +  L    +D     +++    L  DE P
Sbjct: 1639 ESPELKYRETKSQESEELVVTGGGGLRRFKTI-ELNSTIADKYSAESSQKKTSLYFDEEP 1697

Query: 877  EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGG 936
            E +   LT    D++  EG   L  +      +  +      V++L E + S     +  
Sbjct: 1698 ELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTS------VSSLDEDSDSSPSHKK-- 1749

Query: 937  VAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP 996
                  GES+++        GP+  T    ED SE      EE  +E +E+++ + +   
Sbjct: 1750 ------GESKQQRKARHRPHGPLLPTI---EDSSE------EEELREEEELLKEQEKQRE 1794

Query: 997  FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
               +   S  + S+   +E    +     K        + +A    E      L +  ++
Sbjct: 1795 IEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEE------LRQAAEM 1848

Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFK-----------EEQKLKAEEGET 1105
                R +    +   ++D E  E++    ++ +  +K           +EQ +  +EG  
Sbjct: 1849 EELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQ 1908

Query: 1106 ETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNP----GLLGEDSLKETVV 1154
            +    AEE  +   ++        A  E  E+ +      G+L ED + E++V
Sbjct: 1909 KALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLV 1961



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 159/817 (19%), Positives = 312/817 (38%), Gaps = 124/817 (15%)

Query: 429  GKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKP-GQEVLE 487
            G +RK    + P  +  K +   V  + S+Q  KT +   V  V++   + K   ++V+ 
Sbjct: 1120 GDIRK----MPPAPSGPKASPMPVPTESSSQ--KTAVPPQVKLVKKQEQEVKTEAEKVIL 1173

Query: 488  DDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETS 547
            +  + TL  E        ++KQ E   E+ +A        + PL ++K  L PE+E   S
Sbjct: 1174 EKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQE---KKPLPEEK-KLIPEEEKIRS 1229

Query: 548  SQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHT 607
             +K P   +          +    EDK+ +  A +++     +             ++  
Sbjct: 1230 EEKKPLLEE----------KKPTPEDKKLLPEAKTSAPEEQKHDL----------LKSQV 1269

Query: 608  DSSTDESARRSSSQELSENDKP--RKSHLPIEESLEIEIEDQEITKADVETKPMPIDESF 665
              + ++   R + + + E  +P  +   LP      +  ED + TK  ++ +P P   + 
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKT-IKEQPQPPCTAK 1328

Query: 666  ENVLKEGTEKGTQE-----IAEGLSEKSGKHVSAEEKEKD--KSKLWEESTAQVKDKKAG 718
             + ++ G EK  +E      +     KS + +S      D   S L E  +    D+K  
Sbjct: 1329 PDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDI 1388

Query: 719  LPGLEEGG--KDSLPLAYV-LALGAPTMNFMVDETAAINSNKESQQLVQ-------KTYT 768
            L GL++    ++S P +   LA    T+  +++  A+  ++++S++  Q       +   
Sbjct: 1389 LKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKD 1448

Query: 769  LEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEK 828
             EK +++ E       + +I + + E     +  +  + P  + K   E+ E  ++ T +
Sbjct: 1449 QEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIP--SSKDHKEKSEFVDDITTR 1506

Query: 829  REIPPGIERGAEGAAEAEGVRR----LGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLT 884
            RE    +E  +E        R+    +G   SD   Q   +D+ G  ++E   ++ ++  
Sbjct: 1507 REPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQ---EDSQGSGEEEDFIRKQIIEM 1563

Query: 885  VLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGE 944
              + D + SE ++ +                L E+++  E+   EE + +G +       
Sbjct: 1564 SADEDASGSEDDEFIRN-------------QLKEISSSTESQKKEETKGKGKITAGKHRR 1610

Query: 945  SEEEASIDLE-----------------DTGPMEDTASKREDGSEEAILGGEEPAKERKEV 987
               ++S  ++                 D  P       +   SEE ++ G    +  K +
Sbjct: 1611 LTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTI 1670

Query: 988  MRTETRLSPFTGEAEASR------------MQVSEGSPEEGSLAK-EAFLCKEDVEGEEM 1034
                T    ++ E+   +            M+    SPE+ S  +  + L          
Sbjct: 1671 ELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTS 1730

Query: 1035 VTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT--DSEREEVTRANALKDEDAF 1092
             T   +  ED       K+ +  ++R+   RP   L  T  DS  EE  R    ++E+  
Sbjct: 1731 PTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELR----EEEELL 1786

Query: 1093 KEEQKLKAEEGET-----------ETEVRAE---EETKAPPNEMGSDAENEAPVEASELS 1138
            KE++K +  E +            + E+RA+   E  K PP+ + S  E+ +P E    +
Sbjct: 1787 KEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNL-SPIEDASPTEELRQA 1845

Query: 1139 DNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRK 1175
                 L   S  E    I     GFE S E I  ++K
Sbjct: 1846 AEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQK 1882



 Score = 35.0 bits (79), Expect = 0.56
 Identities = 92/551 (16%), Positives = 198/551 (35%), Gaps = 89/551 (16%)

Query: 873  DEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGE 932
            + + +K A+   V    K   E +   EK +L      L++E +  +    +     + E
Sbjct: 1142 ESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLE 1201

Query: 933  AEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTET 992
             +   A+ +     EE  +  E+         K     ++ +L  ++P  E K+++    
Sbjct: 1202 KDKASALQEKKPLPEEKKLIPEE--------EKIRSEEKKPLLEEKKPTPEDKKLLPEAK 1253

Query: 993  RLSPFTGEAEASRMQVSEGSPE-EGSLA----KEAFLCKEDVEGEEMVTEAEANREDDRK 1047
              +P   + +  + QV     + EG +A    +E    +  +EG    T     +EDD+ 
Sbjct: 1254 TSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKT 1313

Query: 1048 EILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDE------DAFKEEQKLKAE 1101
                KE        K ++ +    KT+ E ++   +++ + +      D       + + 
Sbjct: 1314 TKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS 1373

Query: 1102 EGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSD-----------NPGLLGEDSLK 1150
             GE  + +  +E+      +  S ++  +P   S+L+                L ++  +
Sbjct: 1374 LGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSE 1433

Query: 1151 ETVVPIFEATPGFEKSLENITALRKEG----GGERLSEARDTEHKDREELSSRENRALKE 1206
            +   P  E +P   K  E   +L +        E + E+++ E KD  +  S+++    +
Sbjct: 1434 KKTQP-HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE-ERKDTFKKDSQQDIPSSK 1491

Query: 1207 GHRQDGEGAL-AAPEAEPAGKVQ----APEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261
             H++  E         EP   V+    +    +P   +   + +   D     + +  G 
Sbjct: 1492 DHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSG- 1550

Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDME 1321
                          EE+  + ++  E + DED    ED       E ++++  E     E
Sbjct: 1551 --------------EEEDFIRKQIIEMSADEDASGSED------DEFIRNQLKEISSSTE 1590

Query: 1322 GEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDV 1381
             +   +K E  G G++              TA + R +   S T+ ++          D 
Sbjct: 1591 SQ---KKEETKGKGKI--------------TAGKHRRLTRKSSTSIDE----------DA 1623

Query: 1382 AEEETWHQQDE 1392
                +WH +D+
Sbjct: 1624 GRRHSWHDEDD 1634


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 151/748 (20%), Positives = 281/748 (37%), Gaps = 130/748 (17%)

Query: 419  EKGEELKKAEGKVRKEREYV-----IPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVE 473
            ++ E    AEG V K+   +     +PK+ +   +   V      ++  T L+    A  
Sbjct: 845  QERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAET 904

Query: 474  EMTSKG------KPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIP 527
            +  SK       K  Q+ L D  E  LK +  ++   D++KQ +K  EE           
Sbjct: 905  KEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEE----------K 954

Query: 528  QSPLDDKKDNLDPEKESETSS---QKAPDARD------NVKDENDGCSESELEEDKQDMK 578
            + P D KK  +  E++ E+SS   +K P+  +       +K   +G ++ E    K+  K
Sbjct: 955  KKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE----KKSKK 1010

Query: 579  TASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESA------RRSSSQELSENDKPRKS 632
                TS +    S  +E  +  GD     DSS D+ +      R     +L      ++ 
Sbjct: 1011 IRDKTSKKKDELSDYAEKSTGKGDS---CDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQ 1067

Query: 633  HLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHV 692
                 ++ +  +++     +D   K + + E   N+    +++ T+EI  G S    +  
Sbjct: 1068 DCSSSDTEKYSMKEDGCNSSDKRLKRIELRER-RNL---SSKRNTKEIQSGSSSSDAEES 1123

Query: 693  SAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAA 752
            S + K+K +    ++    VK+KK                    +L   T     D T++
Sbjct: 1124 SEDNKKKKQRTSSKKKAVIVKEKKRN------------------SLRTSTKRKQADITSS 1165

Query: 753  INSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAW 812
             +S+ E           + + ++ E  + + +   + +    ++  G   +  +  L   
Sbjct: 1166 SSSDIED----------DDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1215

Query: 813  KPTAEQPELAEEFTEKR--------EIPPGIERGAEGAAE---AEGVRRLGEGGSDPIGQ 861
             P     +  +   E R        EI   +    +G+++    EG +R G+   +  G 
Sbjct: 1216 VPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGD 1275

Query: 862  AAAKDAVGLSKD---EAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHE 918
              AK+ V    D   E  +K      +L      S+GE G EK     E       H   
Sbjct: 1276 EEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKE-------HKEV 1328

Query: 919  VAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGE 978
                R   +SE+ E           +S+ + S   E+    ED    R   +++A L   
Sbjct: 1329 KGRNRRKVSSEDSE-----------DSDFQESGVSEEVSESEDEQRPRTRSAKKAELEEN 1377

Query: 979  EPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEG-SLAKEAFLCKEDVEGEEMVTE 1037
            + + ++K+  R               R++V E S  E  S ++E    KE+ E EE   E
Sbjct: 1378 QRSYKQKKKRR---------------RIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEE 1422

Query: 1038 AEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQK 1097
             E   E+D  +   K     R+  K ++ +T  +    E EE  +  A ++ +  K  + 
Sbjct: 1423 EEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREV 1482

Query: 1098 LKAEEGE-------TETEVRAEEETKAP 1118
            ++ E+         T+  +  +EETK P
Sbjct: 1483 IEIEDASPTKCPITTKLVLDEDEETKEP 1510



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 209/1195 (17%), Positives = 443/1195 (37%), Gaps = 164/1195 (13%)

Query: 414  KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAV 472
            KEK+T++ + +  K E K RK  +    ++ +I +++  +S K   Q     + + V   
Sbjct: 387  KEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRK---QVDSEHMHQNVPTE 443

Query: 473  EEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLD 532
            E+ T+K   G+    D +E               E Q E +N     D+ +  +P S  +
Sbjct: 444  EQRTNKSTGGEHKKSDRKE---------------EPQYEPANTSEDLDMDIVSVPSSVPE 488

Query: 533  DKKDNLDPEKESETSSQKAPDARDNV---------------KDENDGCSESELEEDKQDM 577
            D  +NL+   E ++S     D                    KD   G       +  +++
Sbjct: 489  DIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKEL 548

Query: 578  KTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSS-SQELSENDKPRKSHLPI 636
                +  S S+     ++ +    D++ +     +    +    QE S+N+     HL +
Sbjct: 549  YVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNE-----HL-V 602

Query: 637  EESLEIEIEDQEITKAD-VETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAE 695
            E  + + +E+ ++ ++  V+T P+        V    T    +E  E + EK  + +S  
Sbjct: 603  ENEVSLLLEESDLRRSPRVKTTPLRRPTETNPV----TSNSDEECNETVKEK--QKLSVP 656

Query: 696  EKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINS 755
             ++KDK    + +    K  K       E    +     +LA+        + E + ++ 
Sbjct: 657  VRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAI--------LKEVSRMSH 708

Query: 756  NKESQQLVQKTYTLE------KKEAMEEDEAPQHR-----DADIVQGKGEAALWGEAGAV 804
            +  S   + + +T        K +A ++D+  + R      +D    KG++A   ++  +
Sbjct: 709  SSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSA---KSSII 765

Query: 805  HEAPLRAWKPTAE-QPELAEEF----------TEKREIP-------PGIERGAEGAAEAE 846
             +   +    ++    EL +E           T K+ IP          E+ ++   + +
Sbjct: 766  SKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQ 825

Query: 847  GVRRL---GEGGSDPIGQAAAKDAVGLSKDEAPEKQALM--LTVLETDKAASEGEQGLEK 901
            G + L    EG SD   +   ++    ++    +   +M     L   + AS    G++K
Sbjct: 826  GHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDK 885

Query: 902  AVLANEAAALNLEHLHEVAALREAATSEEGEAEGGV--AVSDVGE-------SEEEASID 952
              L+ +  +     + +VA  +E +   + +    V   +SD+ E       S+E +  D
Sbjct: 886  --LSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDD 943

Query: 953  LEDTGPMEDTASKREDGSEEAILGGE--EPAKERKEVMRTETRLSPFTGEAEASRMQVSE 1010
             + +    +   K  D  ++ I   +  E + +  E +     +  F    +  +   ++
Sbjct: 944  KKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTD 1003

Query: 1011 GSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSL 1070
            G  +   +  +    K+++      +  + +  D  ++   K     RE+++ +    S 
Sbjct: 1004 GEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSS 1063

Query: 1071 RKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEA 1130
            RK        T   ++K++     +++LK  E      + ++  TK    E+ S + +  
Sbjct: 1064 RKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTK----EIQSGSSSSD 1119

Query: 1131 PVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEH 1190
              E+SE  DN       S K+  V + E                     +R S    T+ 
Sbjct: 1120 AEESSE--DNKKKKQRTSSKKKAVIVKEK--------------------KRNSLRTSTKR 1157

Query: 1191 KDREELSSRENRALKEGHRQDGEGALAAPEAEPAGK---VQAPEGLIPATG-----QAEE 1242
            K  +  SS  +    +     GEG+    + +P  +   + +  G   ++G     ++  
Sbjct: 1158 KQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1217

Query: 1243 LAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEE------ 1296
            +   D D     E R             ++ + EE         + + D++PEE      
Sbjct: 1218 VTVDDDDDDNDPENRI-----------AKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTG 1266

Query: 1297 EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEE 1356
            ++++E   + EA    NSE D D E     +    +   ++   +     GE  +T  +E
Sbjct: 1267 KQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSD--GESGEEKKTKPKE 1324

Query: 1357 REVLAGSETAEEKTIANKASSFSDV-AEEETWHQQDELVGKTAAAGKVVVEELARSGEEV 1415
             + + G    +  +  ++ S F +    EE    +DE   +T +A K  +EE  RS ++ 
Sbjct: 1325 HKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQK 1384

Query: 1416 PAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFR 1475
                 + V     +      + E +     +E+EE  E +E    + D +      +K R
Sbjct: 1385 KKRRRIKV-QEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIR 1443

Query: 1476 LGLSREGERELSPESLQAMATLPVKPDFTETREKQQHMVQGESETADVSPNNMQV 1530
              L    + +L  E+  A+     +      RE+++  ++   E  D SP    +
Sbjct: 1444 KILK---DDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPI 1495



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 23/269 (8%)

Query: 404  DKKPSLPKSRKEKSTEKGEELKKAEGKVRKE-----REYVIPK-RNEIKENKTSVSAKFS 457
            D +P   K R  K  E+    ++A+ +V  E      E   P+ R+ +  +K +VS   S
Sbjct: 1255 DDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGES 1314

Query: 458  AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517
             +E KT  KE          KG+  ++V  +D E++   E     EV E +  ++     
Sbjct: 1315 GEEKKTKPKE------HKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRS 1368

Query: 518  QADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDM 577
                ++    +S    KK      +E  +S  K+    +  + E +   E E EE+++D 
Sbjct: 1369 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1428

Query: 578  KTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIE 637
               S +     P     +    + D +  T++           + ++E ++ R+    + 
Sbjct: 1429 NDDSKS-----PGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREV- 1482

Query: 638  ESLEIEIEDQEITKADVETKPMPIDESFE 666
                IEIED   TK  + TK + +DE  E
Sbjct: 1483 ----IEIEDASPTKCPITTK-LVLDEDEE 1506



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 72/348 (20%), Positives = 137/348 (39%), Gaps = 58/348 (16%)

Query: 405  KKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG 464
            KK  + K +K  S     + K+A+       +     +N I E  +        Q+IK  
Sbjct: 1138 KKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD------EQKIKPV 1191

Query: 465  LKEVV---------TAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNE 515
             + +V         ++ +E  SK  P   V +DD +N  +    +   ++E K    S+E
Sbjct: 1192 TENLVLSSHTGFCQSSGDEALSKSVP-VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE 1250

Query: 516  EGQADVQMNG--------IPQSPLDDK-KDNLDPEKESETSSQKAPDARDNVKDENDGCS 566
            +G +D +             ++P D++ K+ ++ E +S++   K P  R  +       S
Sbjct: 1251 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS 1310

Query: 567  ESELEEDKQDMKTASST---SSRSHPYSSDSED----ESAVGDREAHTDSSTDESARRSS 619
            + E  E+K+            +R    S DSED    ES V +  + ++       R + 
Sbjct: 1311 DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAK 1370

Query: 620  SQELSEND-----KPRKSHLPIEESLEIEI------EDQEITKADVETKPMPIDESFENV 668
              EL EN      K ++  + ++E    E       E++E  + + E +    +E  EN 
Sbjct: 1371 KAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDEND 1430

Query: 669  LKEGTEKGTQEIAEGLS---------------EKSGKHVSAEEKEKDK 701
              +   KG ++I + L                E+  K ++  E+E++K
Sbjct: 1431 DSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK 1478



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 54/256 (21%), Positives = 97/256 (37%), Gaps = 27/256 (10%)

Query: 959  MEDTASKREDGSEEAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRM---- 1006
            ++D+ S     S  A++  +E  K+ K+++ T           L   T  +E S      
Sbjct: 293  LDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLR 352

Query: 1007 QVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
            Q+         + K     +ED+  E    +A  N+E + KE    +     + RK E+P
Sbjct: 353  QLKAFKSVLADIKKAHLALEEDLNSEFRAMDA-VNKEKNTKEHKVIDAKFETKARKGEKP 411

Query: 1067 KTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126
              +L K D  + E   +   K  D+    Q +  EE  T      E +      E   + 
Sbjct: 412  -CALEKKDISKSEAKLSR--KQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEP 468

Query: 1127 ENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEAR 1186
             N +     ++   P  + ED        IFE     E ++E  +++  +G G   +E  
Sbjct: 469  ANTSEDLDMDIVSVPSSVPED--------IFE---NLETAMEVQSSVDHQGDGSSGTEQE 517

Query: 1187 DTEHKDREELSSRENR 1202
                  +  +SS++NR
Sbjct: 518  VESSSVKLNISSKDNR 533



 Score = 36.6 bits (83), Expect = 0.19
 Identities = 142/741 (19%), Positives = 269/741 (36%), Gaps = 115/741 (15%)

Query: 864  AKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNL-----EHLHE 918
            A DAV  +K++  ++  ++    ET     E    LEK  ++   A L+      EH+H+
Sbjct: 381  AMDAV--NKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQ 438

Query: 919  VAALREAATS-------------EEGEAEGGVAVSDV--------GESEEEASIDLEDTG 957
                 E  T+             EE + E      D+            E+   +LE   
Sbjct: 439  NVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAM 498

Query: 958  PMEDTASKREDGS-------EEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVS- 1009
             ++ +   + DGS       E + +     +K+ +  ++++T  +  T E       VS 
Sbjct: 499  EVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTT-AKVTKELYVKLTPVSL 557

Query: 1010 EGSPEEGSLAKEAFLCKEDVEGEEMVTEAE----ANREDDRKEILPKELDLARER---RK 1062
              SP +G+  +E    K+  +   +  + E         D + ++  E+ L  E    R+
Sbjct: 558  SNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRR 617

Query: 1063 AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAP-PNE 1121
            + R KT+  +  +E   VT  +  +  +  KE+QKL     + +    ++     P PN+
Sbjct: 618  SPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNK 677

Query: 1122 MGSDAENEAPVEASELSDNPGLLGE------DSLKETVVPIFEATPGFEKSLENITALRK 1175
            +    ++E   + S+  +   +L E       S  +T +            L+       
Sbjct: 678  LPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDD 737

Query: 1176 EGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
            +G  +R S    ++   ++  S++ +   K+  +   E +    E E   K  +  G   
Sbjct: 738  KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAAR 797

Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPE 1295
             T +      KD DS    E     + G+D                  K  +E   +D E
Sbjct: 798  TT-KKRIPNTKDFDSS---EDEKHSKKGMD-----------NQGHKNLKTSQEGSSDDAE 842

Query: 1296 EEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAE 1355
             ++++E     E   D+++     ME      K +         V+ L  G E + T+ E
Sbjct: 843  RKQERETFSSAEGTVDKDTT---IMELRDRLPKKQ-QASASTDGVDKL-SGKEQSFTSLE 897

Query: 1356 EREVLAGSETAEE---KTIANKASSFSDVAEE-------ETWHQQDELVGKTAAAGK--- 1402
             R+V    E ++    KT        SD+AE+       +   + D+   K     K   
Sbjct: 898  VRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP 957

Query: 1403 -------VVVEELARSG----EEVPAAEEM--------TVTYTTEAGVGTPGALERKTSG 1443
                   + +E+   S     E++P  EE+         +   T  G      +  KTS 
Sbjct: 958  SDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTS- 1016

Query: 1444 LGQEQEEGSEGQEAATGSGDG-------RQETGA--AEKFRLGLSREGERELSPESLQAM 1494
              ++++E S+  E +TG GD        + + GA   EK R  L  +  R+    S    
Sbjct: 1017 --KKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDT 1074

Query: 1495 ATLPVKPDFTETREKQQHMVQ 1515
                +K D   + +K+   ++
Sbjct: 1075 EKYSMKEDGCNSSDKRLKRIE 1095



 Score = 33.9 bits (76), Expect = 1.2
 Identities = 25/99 (25%), Positives = 42/99 (42%), Gaps = 12/99 (12%)

Query: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSS-------- 592
           E+  ETSS        N    +   S S++ E+ ++  T+SS  S+S   S         
Sbjct: 27  EESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIV 86

Query: 593 ----DSEDESAVGDREAHTDSSTDESARRSSSQELSEND 627
               +S+DE  + D   + D+S + S    + Q L + D
Sbjct: 87  TKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKED 125


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)

Query: 417  STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
            +T+K +EL+    KVR E E ++  +   +E   S S K   + E + G    L E    
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805

Query: 472  VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
            +  +  + K  +++ E+D     + E E          GE +  + +A++ +        
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1857

Query: 532  DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
                   + E E+E   + A D     +  +E     ++++EE    ++ AS S   R  
Sbjct: 1858 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910

Query: 589  PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
                D+  +    + E     ++ E A    ++   EL       +  L  +E  E+E  
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
             Q    A+ E +    +E  +  L    E   Q  A  L E        EE  + + +  
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2029

Query: 706  EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
            +ES  Q++                      LA  A       +E A   + ++ +Q +Q+
Sbjct: 2030 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067

Query: 766  TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
              TL++++++           D ++G+ EAA    A    EA ++A +  A+     EE 
Sbjct: 2068 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2113

Query: 826  TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
                      ER  + A E    R   +  ++ + + A ++A   ++ E    +      
Sbjct: 2114 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164

Query: 886  LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
             E +K     EQ L +KA +  E   L L   E  H+   L E     + EA E     S
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224

Query: 941  DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
             V E      + +E+   ++            R+  + +  L  +E A++ K+V     R
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2282

Query: 994  LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
            LS    EA   R    E   ++ +LA       E +  E+M    EA R     E+L ++
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2335

Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
             +LA+E+          R+   ++E++ +  A   E+    ++ L+AE  + + E+ AE 
Sbjct: 2336 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2382

Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
            E  K    EM S A+  A  +A         +GE   +  +    + T    ++LE I  
Sbjct: 2383 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2438

Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
             + +   ERL EA     +++E+L                E  L   ++E    VQ  E 
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2483

Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
            L+  T   ++    + DS    E   E Q    +    Q+ VA+   +  E+ R++   E
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542

Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
               +      EE +    E E    R  E    +E +   Q+ E +        E L   
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2601

Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
             E    A    E +  S+ A  KT+ N   +     AE E  H  D L  K +A     A
Sbjct: 2602 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2661

Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
            G +  EEL R  +     +E+
Sbjct: 2662 GILSAEELQRLAQGHTTVDEL 2682



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)

Query: 414  KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
            K+++ +  EEL+ +AE   R+ R+  + +  +++    +   SA+   Q  +    E   
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590

Query: 471  AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
             +E    +       L ++ E   + + E     E+ E + E+   K+NE  +  +Q   
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650

Query: 526  IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
            + Q          + EK+ E + +   +AR   K E     + EL E + + +   +  +
Sbjct: 1651 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704

Query: 586  RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
                 +++ E            ++   E  R+   +EL+   +   +     + LE E+ 
Sbjct: 1705 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
                 +A++E   +      E   +  +EK  Q + AE      L+E++ +  +  E+ K
Sbjct: 1759 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814

Query: 700  DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
             + +L EE  A+           +    + +    + A+G  T      E A      E+
Sbjct: 1815 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863

Query: 760  QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
            ++L +       +    E++A QH+ ADI +   +     ++    +  L   + T  Q 
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1920

Query: 820  ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
               EE  E   +    E+ A G AE E    LG   S+      +K+   L   EA  ++
Sbjct: 1921 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1973

Query: 880  ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
             L     E ++   E E+ ++K++ A E AA   +     AAL E    +  + E    +
Sbjct: 1974 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2024

Query: 940  SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
             +  E E    + L      ++ A KR    E+A     ++  +E ++ ++ E   L   
Sbjct: 2025 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079

Query: 998  TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
             GEAEA+R    E   EE  +  E    +E  +    V EAE  ++   ++        A
Sbjct: 2080 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2125

Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            + R +A+     LRK ++E+E   RA A  ++ A +++Q   A + E E   +  E+T  
Sbjct: 2126 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2179

Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
               ++  +      ++  E      LL E+   LK             E+ L       E
Sbjct: 2180 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238

Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
             ++ L+     E R    RD ++  R      E   +K+   +    ++AA EA    ++
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296

Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
             A E L      AE++  +   +      L+  AE       +L+ Q+ +A+E     ++
Sbjct: 2297 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2348

Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
             +E+   +  EE +  + TLE E  +      + +                E + Q    
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
                      + E     +V  V+ L    + ++  AE  RE +A  E  +EK +  +A 
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2467

Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
                 +EE    QQ++L+ +T A  +  + E
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
            +S+++   E   + + A  + R+ RE       E +  K+  + + +A++ K  L+EV  
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2011

Query: 471  AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
              E + +K +  + + E  +QE+  + +  ++      +  EK++    A  Q     Q 
Sbjct: 2012 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2067

Query: 530  PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
             L  ++  LD  + E+E + + A +A +  V+ E +        E+ + +K ++   +++
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127

Query: 588  HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
               +  + ++     ++EA   +  +++A R      +E +K +K     L  +  +E E
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187

Query: 644  IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
            +    +   + + +   +DE  + +  E TE   Q  ++   E     V  EE  K K++
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2246

Query: 704  LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
            +  E+ A + +DK      L+E  +    +A   A     ++    E A +    E    
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2302

Query: 763  VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
             Q+   L +K   E+ +A Q    +  + K EA L  +   + +   R  +   EQ  +A
Sbjct: 2303 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2354

Query: 823  EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
            ++  E+ +       G +   EAE  R+L                     + + E + L 
Sbjct: 2355 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2386

Query: 883  LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
            L V E  +A +  E+  ++     +A  +  E LH      E AT E+      + +   
Sbjct: 2387 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2439

Query: 943  GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
             +S+ +A    E    +E    K +  ++   L  EE    ++E +  ET+         
Sbjct: 2440 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2490

Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
               +Q S  S ++  L +E F+ +E  + E++    V +A+  RE+ +++    E +  R
Sbjct: 2491 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547

Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
                    RR+    +  +R+   E +++ +    ++E   +E Q+L+ +    E + RA
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607

Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
                        S+    + V A++   N    G D+L     P  EA P  E S +   
Sbjct: 2608 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2647

Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
             LR++   +RL EA          LS+ E + L +GH
Sbjct: 2648 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2676



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)

Query: 886  LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
            +E ++  +E ++  E+  LA   AAL  +     A  +  A +E    E    + +    
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403

Query: 946  EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
             EEA++D +       E+    R+    E      +     +  +R E  +     + EA
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463

Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
            +  Q      E  +L   A    E+ E ++   + EA R   R+++     D ++ +R+A
Sbjct: 1464 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1513

Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
            E    S  K ++E  RE+     AL       EE +L+AEE E    + EV    + +  
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1566

Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
                   AE E   + +  ++    L E SL+E  V + +     E+  +      ++  
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1619

Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
             ER   AR+   ++ E    + N AL+   +      + +LA  EAE   + +  E    
Sbjct: 1620 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1674

Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
              G+AEE A +  +     LE + +   G       Q+ +A E  ++  +   E  ++  
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1729

Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
            +  E++   L+ EA        + + E      + E +   +  A E       T+E + 
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1786

Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
            +  E  AG       E A  + +A +A     +AEE+   Q+       A A +V+ E+L
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1839

Query: 1409 ARSGE 1413
            A  GE
Sbjct: 1840 AAIGE 1844



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)

Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
            EE    AE  R ++R+ +   E++ A E+++      +  K  +ERE       +++E  
Sbjct: 1345 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402

Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
             +EE  + A++ +   +   ++  ++      S+AE +A    +E ++   L  E+ ++ 
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1456

Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
              + + EAT     G E  L+ + A  +E   ++     + E   R+             
Sbjct: 1457 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515

Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
            EL+SR   E  A +E  R            ++ E  L   E E A +VQ        + +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
            AE     A   +  A LE   + +      LR +     +    AE+ REEA  E    +
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635

Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
                  L      +  ++     + E   QK E        A       G+  E A  +R
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1687

Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
            E LA  E  +++ +A   +     AE+E    + E   +     +++ EELAR   E  A
Sbjct: 1688 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1745

Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
            A +       E        +E   +   + +EE    SE  +    +  GR    A E  
Sbjct: 1746 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804

Query: 1475 RL-GLSREGERE 1485
            RL  L+ E +R+
Sbjct: 1805 RLRALAEEAKRQ 1816



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)

Query: 800  EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
            E   VH   L   K  A   E A+   E+++    +E   +G    +AEAE V  L E  
Sbjct: 1000 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057

Query: 856  -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
             + P  ++  +  +G   ++     A+ L  L+T      G QG E+ + A+E       
Sbjct: 1058 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116

Query: 908  AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            A    L  L    A+L++     E +     A+ D     +E    L+      D   +R
Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176

Query: 967  --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
              E  ++     +A+L   +  +   E +  + R        L  +  +A   + Q+   
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236

Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
              ++       L +E  L +E     E V E +   +     I   EL L   + + E  
Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296

Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
             +  +K      ++S  +E         E      Q +K     +ET  R EEE +    
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1353

Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
            +   + E  A VEA+                            EK    +     +   +
Sbjct: 1354 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1385

Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
               EA++ + + +EE+  RE  A+     K   +++ +    + EAE   K +  E    
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445

Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
            +  + EE   +       LE     +GG +  L+   A AEE      + +EEA  +   
Sbjct: 1446 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
             ++E  ++   E E      +E +   E +   Q           A+E L    E AE  
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1551

Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
              +      R+V    ETA+   E  + +K +SF++   +     Q+E V    A  +  
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1609

Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
             E  A+   E   A E          +    AL      L  + EE ++ +  A    + 
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1664

Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
            ++E    E  R G + E    +REL+ + L+    L
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700



 Score = 37.7 bits (86), Expect = 0.086
 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)

Query: 457  SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
            SA+   TG K+  +       +      +L+D     L+ +      +D E+      E 
Sbjct: 4006 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4065

Query: 513  SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
            + + G  D +MN I   P DD K   DP  E   +  +  +    + D   G     L+E
Sbjct: 4066 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4123

Query: 573  DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
             K++ KT+S +S R             + D E   + S  E+ R+             ++
Sbjct: 4124 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4167

Query: 633  HLPIEESLEIEIEDQEITKADVETKPMPID 662
            +L + E  E E E+  I+ +D   K M ID
Sbjct: 4168 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4196


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)

Query: 417  STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
            +T+K +EL+    KVR E E ++  +   +E   S S K   + E + G    L E    
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1809

Query: 472  VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
            +  +  + K  +++ E+D     + E E          GE +  + +A++ +        
Sbjct: 1810 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1861

Query: 532  DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
                   + E E+E   + A D     +  +E     ++++EE    ++ AS S   R  
Sbjct: 1862 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1914

Query: 589  PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
                D+  +    + E     ++ E A    ++   EL       +  L  +E  E+E  
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
             Q    A+ E +    +E  +  L    E   Q  A  L E        EE  + + +  
Sbjct: 1975 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2033

Query: 706  EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
            +ES  Q++                      LA  A       +E A   + ++ +Q +Q+
Sbjct: 2034 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2071

Query: 766  TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
              TL++++++           D ++G+ EAA    A    EA ++A +  A+     EE 
Sbjct: 2072 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2117

Query: 826  TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
                      ER  + A E    R   +  ++ + + A ++A   ++ E    +      
Sbjct: 2118 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168

Query: 886  LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
             E +K     EQ L +KA +  E   L L   E  H+   L E     + EA E     S
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228

Query: 941  DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
             V E      + +E+   ++            R+  + +  L  +E A++ K+V     R
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2286

Query: 994  LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
            LS    EA   R    E   ++ +LA       E +  E+M    EA R     E+L ++
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2339

Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
             +LA+E+          R+   ++E++ +  A   E+    ++ L+AE  + + E+ AE 
Sbjct: 2340 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2386

Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
            E  K    EM S A+  A  +A         +GE   +  +    + T    ++LE I  
Sbjct: 2387 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2442

Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
             + +   ERL EA     +++E+L                E  L   ++E    VQ  E 
Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2487

Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
            L+  T   ++    + DS    E   E Q    +    Q+ VA+   +  E+ R++   E
Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546

Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
               +      EE +    E E    R  E    +E +   Q+ E +        E L   
Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2605

Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
             E    A    E +  S+ A  KT+ N   +     AE E  H  D L  K +A     A
Sbjct: 2606 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2665

Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
            G +  EEL R  +     +E+
Sbjct: 2666 GILSAEELQRLAQGHTTVDEL 2686



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)

Query: 414  KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
            K+++ +  EEL+ +AE   R+ R+  + +  +++    +   SA+   Q  +    E   
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1594

Query: 471  AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
             +E    +       L ++ E   + + E     E+ E + E+   K+NE  +  +Q   
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654

Query: 526  IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
            + Q          + EK+ E + +   +AR   K E     + EL E + + +   +  +
Sbjct: 1655 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708

Query: 586  RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
                 +++ E            ++   E  R+   +EL+   +   +     + LE E+ 
Sbjct: 1709 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
                 +A++E   +      E   +  +EK  Q + AE      L+E++ +  +  E+ K
Sbjct: 1763 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818

Query: 700  DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
             + +L EE  A+           +    + +    + A+G  T      E A      E+
Sbjct: 1819 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867

Query: 760  QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
            ++L +       +    E++A QH+ ADI +   +     ++    +  L   + T  Q 
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1924

Query: 820  ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
               EE  E   +    E+ A G AE E    LG   S+      +K+   L   EA  ++
Sbjct: 1925 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1977

Query: 880  ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
             L     E ++   E E+ ++K++ A E AA   +     AAL E    +  + E    +
Sbjct: 1978 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2028

Query: 940  SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
             +  E E    + L      ++ A KR    E+A     ++  +E ++ ++ E   L   
Sbjct: 2029 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083

Query: 998  TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
             GEAEA+R    E   EE  +  E    +E  +    V EAE  ++   ++        A
Sbjct: 2084 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2129

Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            + R +A+     LRK ++E+E   RA A  ++ A +++Q   A + E E   +  E+T  
Sbjct: 2130 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2183

Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
               ++  +      ++  E      LL E+   LK             E+ L       E
Sbjct: 2184 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242

Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
             ++ L+     E R    RD ++  R      E   +K+   +    ++AA EA    ++
Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300

Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
             A E L      AE++  +   +      L+  AE       +L+ Q+ +A+E     ++
Sbjct: 2301 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2352

Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
             +E+   +  EE +  + TLE E  +      + +                E + Q    
Sbjct: 2353 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412

Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
                      + E     +V  V+ L    + ++  AE  RE +A  E  +EK +  +A 
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2471

Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
                 +EE    QQ++L+ +T A  +  + E
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2502



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
            +S+++   E   + + A  + R+ RE       E +  K+  + + +A++ K  L+EV  
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2015

Query: 471  AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
              E + +K +  + + E  +QE+  + +  ++      +  EK++    A  Q     Q 
Sbjct: 2016 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2071

Query: 530  PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
             L  ++  LD  + E+E + + A +A +  V+ E +        E+ + +K ++   +++
Sbjct: 2072 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131

Query: 588  HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
               +  + ++     ++EA   +  +++A R      +E +K +K     L  +  +E E
Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191

Query: 644  IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
            +    +   + + +   +DE  + +  E TE   Q  ++   E     V  EE  K K++
Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2250

Query: 704  LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
            +  E+ A + +DK      L+E  +    +A   A     ++    E A +    E    
Sbjct: 2251 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2306

Query: 763  VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
             Q+   L +K   E+ +A Q    +  + K EA L  +   + +   R  +   EQ  +A
Sbjct: 2307 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2358

Query: 823  EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
            ++  E+ +       G +   EAE  R+L                     + + E + L 
Sbjct: 2359 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2390

Query: 883  LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
            L V E  +A +  E+  ++     +A  +  E LH      E AT E+      + +   
Sbjct: 2391 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2443

Query: 943  GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
             +S+ +A    E    +E    K +  ++   L  EE    ++E +  ET+         
Sbjct: 2444 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2494

Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
               +Q S  S ++  L +E F+ +E  + E++    V +A+  RE+ +++    E +  R
Sbjct: 2495 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2551

Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
                    RR+    +  +R+   E +++ +    ++E   +E Q+L+ +    E + RA
Sbjct: 2552 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2611

Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
                        S+    + V A++   N    G D+L     P  EA P  E S +   
Sbjct: 2612 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2651

Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
             LR++   +RL EA          LS+ E + L +GH
Sbjct: 2652 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2680



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)

Query: 886  LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
            +E ++  +E ++  E+  LA   AAL  +     A  +  A +E    E    + +    
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407

Query: 946  EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
             EEA++D +       E+    R+    E      +     +  +R E  +     + EA
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1467

Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
            +  Q      E  +L   A    E+ E ++   + EA R   R+++     D ++ +R+A
Sbjct: 1468 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1517

Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
            E    S  K ++E  RE+     AL       EE +L+AEE E    + EV    + +  
Sbjct: 1518 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1570

Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
                   AE E   + +  ++    L E SL+E  V + +     E+  +      ++  
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1623

Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
             ER   AR+   ++ E    + N AL+   +      + +LA  EAE   + +  E    
Sbjct: 1624 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1678

Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
              G+AEE A +  +     LE + +   G       Q+ +A E  ++  +   E  ++  
Sbjct: 1679 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1733

Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
            +  E++   L+ EA        + + E      + E +   +  A E       T+E + 
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1790

Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
            +  E  AG       E A  + +A +A     +AEE+   Q+       A A +V+ E+L
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1843

Query: 1409 ARSGE 1413
            A  GE
Sbjct: 1844 AAIGE 1848



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)

Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
            EE    AE  R ++R+ +   E++ A E+++      +  K  +ERE       +++E  
Sbjct: 1349 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406

Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
             +EE  + A++ +   +   ++  ++      S+AE +A    +E ++   L  E+ ++ 
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1460

Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
              + + EAT     G E  L+ + A  +E   ++     + E   R+             
Sbjct: 1461 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519

Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
            EL+SR   E  A +E  R            ++ E  L   E E A +VQ        + +
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579

Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
            AE     A   +  A LE   + +      LR +     +    AE+ REEA  E    +
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639

Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
                  L      +  ++     + E   QK E        A       G+  E A  +R
Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1691

Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
            E LA  E  +++ +A   +     AE+E    + E   +     +++ EELAR   E  A
Sbjct: 1692 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1749

Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
            A +       E        +E   +   + +EE    SE  +    +  GR    A E  
Sbjct: 1750 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1808

Query: 1475 RL-GLSREGERE 1485
            RL  L+ E +R+
Sbjct: 1809 RLRALAEEAKRQ 1820



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)

Query: 800  EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
            E   VH   L   K  A   E A+   E+++    +E   +G    +AEAE V  L E  
Sbjct: 1004 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061

Query: 856  -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
             + P  ++  +  +G   ++     A+ L  L+T      G QG E+ + A+E       
Sbjct: 1062 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1120

Query: 908  AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            A    L  L    A+L++     E +     A+ D     +E    L+      D   +R
Sbjct: 1121 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1180

Query: 967  --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
              E  ++     +A+L   +  +   E +  + R        L  +  +A   + Q+   
Sbjct: 1181 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1240

Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
              ++       L +E  L +E     E V E +   +     I   EL L   + + E  
Sbjct: 1241 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1300

Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
             +  +K      ++S  +E         E      Q +K     +ET  R EEE +    
Sbjct: 1301 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1357

Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
            +   + E  A VEA+                            EK    +     +   +
Sbjct: 1358 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1389

Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
               EA++ + + +EE+  RE  A+     K   +++ +    + EAE   K +  E    
Sbjct: 1390 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449

Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
            +  + EE   +       LE     +GG +  L+   A AEE      + +EEA  +   
Sbjct: 1450 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506

Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
             ++E  ++   E E      +E +   E +   Q           A+E L    E AE  
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1555

Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
              +      R+V    ETA+   E  + +K +SF++   +     Q+E V    A  +  
Sbjct: 1556 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1613

Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
             E  A+   E   A E          +    AL      L  + EE ++ +  A    + 
Sbjct: 1614 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1668

Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
            ++E    E  R G + E    +REL+ + L+    L
Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1704



 Score = 37.7 bits (86), Expect = 0.086
 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)

Query: 457  SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
            SA+   TG K+  +       +      +L+D     L+ +      +D E+      E 
Sbjct: 4010 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4069

Query: 513  SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
            + + G  D +MN I   P DD K   DP  E   +  +  +    + D   G     L+E
Sbjct: 4070 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4127

Query: 573  DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
             K++ KT+S +S R             + D E   + S  E+ R+             ++
Sbjct: 4128 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4171

Query: 633  HLPIEESLEIEIEDQEITKADVETKPMPID 662
            +L + E  E E E+  I+ +D   K M ID
Sbjct: 4172 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4200


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)

Query: 417  STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
            +T+K +EL+    KVR E E ++  +   +E   S S K   + E + G    L E    
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805

Query: 472  VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
            +  +  + K  +++ E+D     + E E          GE +  + +A++ +        
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1857

Query: 532  DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
                   + E E+E   + A D     +  +E     ++++EE    ++ AS S   R  
Sbjct: 1858 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910

Query: 589  PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
                D+  +    + E     ++ E A    ++   EL       +  L  +E  E+E  
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
             Q    A+ E +    +E  +  L    E   Q  A  L E        EE  + + +  
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2029

Query: 706  EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
            +ES  Q++                      LA  A       +E A   + ++ +Q +Q+
Sbjct: 2030 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067

Query: 766  TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
              TL++++++           D ++G+ EAA    A    EA ++A +  A+     EE 
Sbjct: 2068 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2113

Query: 826  TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
                      ER  + A E    R   +  ++ + + A ++A   ++ E    +      
Sbjct: 2114 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164

Query: 886  LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
             E +K     EQ L +KA +  E   L L   E  H+   L E     + EA E     S
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224

Query: 941  DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
             V E      + +E+   ++            R+  + +  L  +E A++ K+V     R
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2282

Query: 994  LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
            LS    EA   R    E   ++ +LA       E +  E+M    EA R     E+L ++
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2335

Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
             +LA+E+          R+   ++E++ +  A   E+    ++ L+AE  + + E+ AE 
Sbjct: 2336 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2382

Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
            E  K    EM S A+  A  +A         +GE   +  +    + T    ++LE I  
Sbjct: 2383 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2438

Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
             + +   ERL EA     +++E+L                E  L   ++E    VQ  E 
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2483

Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
            L+  T   ++    + DS    E   E Q    +    Q+ VA+   +  E+ R++   E
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542

Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
               +      EE +    E E    R  E    +E +   Q+ E +        E L   
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2601

Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
             E    A    E +  S+ A  KT+ N   +     AE E  H  D L  K +A     A
Sbjct: 2602 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2661

Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
            G +  EEL R  +     +E+
Sbjct: 2662 GILSAEELQRLAQGHTTVDEL 2682



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)

Query: 414  KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
            K+++ +  EEL+ +AE   R+ R+  + +  +++    +   SA+   Q  +    E   
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590

Query: 471  AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
             +E    +       L ++ E   + + E     E+ E + E+   K+NE  +  +Q   
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650

Query: 526  IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
            + Q          + EK+ E + +   +AR   K E     + EL E + + +   +  +
Sbjct: 1651 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704

Query: 586  RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
                 +++ E            ++   E  R+   +EL+   +   +     + LE E+ 
Sbjct: 1705 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
                 +A++E   +      E   +  +EK  Q + AE      L+E++ +  +  E+ K
Sbjct: 1759 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814

Query: 700  DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
             + +L EE  A+           +    + +    + A+G  T      E A      E+
Sbjct: 1815 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863

Query: 760  QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
            ++L +       +    E++A QH+ ADI +   +     ++    +  L   + T  Q 
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1920

Query: 820  ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
               EE  E   +    E+ A G AE E    LG   S+      +K+   L   EA  ++
Sbjct: 1921 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1973

Query: 880  ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
             L     E ++   E E+ ++K++ A E AA   +     AAL E    +  + E    +
Sbjct: 1974 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2024

Query: 940  SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
             +  E E    + L      ++ A KR    E+A     ++  +E ++ ++ E   L   
Sbjct: 2025 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079

Query: 998  TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
             GEAEA+R    E   EE  +  E    +E  +    V EAE  ++   ++        A
Sbjct: 2080 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2125

Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            + R +A+     LRK ++E+E   RA A  ++ A +++Q   A + E E   +  E+T  
Sbjct: 2126 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2179

Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
               ++  +      ++  E      LL E+   LK             E+ L       E
Sbjct: 2180 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238

Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
             ++ L+     E R    RD ++  R      E   +K+   +    ++AA EA    ++
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296

Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
             A E L      AE++  +   +      L+  AE       +L+ Q+ +A+E     ++
Sbjct: 2297 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2348

Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
             +E+   +  EE +  + TLE E  +      + +                E + Q    
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
                      + E     +V  V+ L    + ++  AE  RE +A  E  +EK +  +A 
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2467

Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
                 +EE    QQ++L+ +T A  +  + E
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
            +S+++   E   + + A  + R+ RE       E +  K+  + + +A++ K  L+EV  
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2011

Query: 471  AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
              E + +K +  + + E  +QE+  + +  ++      +  EK++    A  Q     Q 
Sbjct: 2012 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2067

Query: 530  PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
             L  ++  LD  + E+E + + A +A +  V+ E +        E+ + +K ++   +++
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127

Query: 588  HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
               +  + ++     ++EA   +  +++A R      +E +K +K     L  +  +E E
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187

Query: 644  IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
            +    +   + + +   +DE  + +  E TE   Q  ++   E     V  EE  K K++
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2246

Query: 704  LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
            +  E+ A + +DK      L+E  +    +A   A     ++    E A +    E    
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2302

Query: 763  VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
             Q+   L +K   E+ +A Q    +  + K EA L  +   + +   R  +   EQ  +A
Sbjct: 2303 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2354

Query: 823  EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
            ++  E+ +       G +   EAE  R+L                     + + E + L 
Sbjct: 2355 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2386

Query: 883  LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
            L V E  +A +  E+  ++     +A  +  E LH      E AT E+      + +   
Sbjct: 2387 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2439

Query: 943  GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
             +S+ +A    E    +E    K +  ++   L  EE    ++E +  ET+         
Sbjct: 2440 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2490

Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
               +Q S  S ++  L +E F+ +E  + E++    V +A+  RE+ +++    E +  R
Sbjct: 2491 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547

Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
                    RR+    +  +R+   E +++ +    ++E   +E Q+L+ +    E + RA
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607

Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
                        S+    + V A++   N    G D+L     P  EA P  E S +   
Sbjct: 2608 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2647

Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
             LR++   +RL EA          LS+ E + L +GH
Sbjct: 2648 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2676



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)

Query: 886  LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
            +E ++  +E ++  E+  LA   AAL  +     A  +  A +E    E    + +    
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403

Query: 946  EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
             EEA++D +       E+    R+    E      +     +  +R E  +     + EA
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463

Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
            +  Q      E  +L   A    E+ E ++   + EA R   R+++     D ++ +R+A
Sbjct: 1464 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1513

Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
            E    S  K ++E  RE+     AL       EE +L+AEE E    + EV    + +  
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1566

Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
                   AE E   + +  ++    L E SL+E  V + +     E+  +      ++  
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1619

Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
             ER   AR+   ++ E    + N AL+   +      + +LA  EAE   + +  E    
Sbjct: 1620 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1674

Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
              G+AEE A +  +     LE + +   G       Q+ +A E  ++  +   E  ++  
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1729

Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
            +  E++   L+ EA        + + E      + E +   +  A E       T+E + 
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1786

Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
            +  E  AG       E A  + +A +A     +AEE+   Q+       A A +V+ E+L
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1839

Query: 1409 ARSGE 1413
            A  GE
Sbjct: 1840 AAIGE 1844



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)

Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
            EE    AE  R ++R+ +   E++ A E+++      +  K  +ERE       +++E  
Sbjct: 1345 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402

Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
             +EE  + A++ +   +   ++  ++      S+AE +A    +E ++   L  E+ ++ 
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1456

Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
              + + EAT     G E  L+ + A  +E   ++     + E   R+             
Sbjct: 1457 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515

Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
            EL+SR   E  A +E  R            ++ E  L   E E A +VQ        + +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
            AE     A   +  A LE   + +      LR +     +    AE+ REEA  E    +
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635

Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
                  L      +  ++     + E   QK E        A       G+  E A  +R
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1687

Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
            E LA  E  +++ +A   +     AE+E    + E   +     +++ EELAR   E  A
Sbjct: 1688 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1745

Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
            A +       E        +E   +   + +EE    SE  +    +  GR    A E  
Sbjct: 1746 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804

Query: 1475 RL-GLSREGERE 1485
            RL  L+ E +R+
Sbjct: 1805 RLRALAEEAKRQ 1816



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)

Query: 800  EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
            E   VH   L   K  A   E A+   E+++    +E   +G    +AEAE V  L E  
Sbjct: 1000 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057

Query: 856  -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
             + P  ++  +  +G   ++     A+ L  L+T      G QG E+ + A+E       
Sbjct: 1058 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116

Query: 908  AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            A    L  L    A+L++     E +     A+ D     +E    L+      D   +R
Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176

Query: 967  --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
              E  ++     +A+L   +  +   E +  + R        L  +  +A   + Q+   
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236

Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
              ++       L +E  L +E     E V E +   +     I   EL L   + + E  
Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296

Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
             +  +K      ++S  +E         E      Q +K     +ET  R EEE +    
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1353

Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
            +   + E  A VEA+                            EK    +     +   +
Sbjct: 1354 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1385

Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
               EA++ + + +EE+  RE  A+     K   +++ +    + EAE   K +  E    
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445

Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
            +  + EE   +       LE     +GG +  L+   A AEE      + +EEA  +   
Sbjct: 1446 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
             ++E  ++   E E      +E +   E +   Q           A+E L    E AE  
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1551

Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
              +      R+V    ETA+   E  + +K +SF++   +     Q+E V    A  +  
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1609

Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
             E  A+   E   A E          +    AL      L  + EE ++ +  A    + 
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1664

Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
            ++E    E  R G + E    +REL+ + L+    L
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700



 Score = 37.7 bits (86), Expect = 0.086
 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)

Query: 457  SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
            SA+   TG K+  +       +      +L+D     L+ +      +D E+      E 
Sbjct: 4006 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4065

Query: 513  SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
            + + G  D +MN I   P DD K   DP  E   +  +  +    + D   G     L+E
Sbjct: 4066 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4123

Query: 573  DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
             K++ KT+S +S R             + D E   + S  E+ R+             ++
Sbjct: 4124 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4167

Query: 633  HLPIEESLEIEIEDQEITKADVETKPMPID 662
            +L + E  E E E+  I+ +D   K M ID
Sbjct: 4168 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4196


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)

Query: 417  STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
            +T+K +EL+    KVR E E ++  +   +E   S S K   + E + G    L E    
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773

Query: 472  VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
            +  +  + K  +++ E+D     + E E          GE +  + +A++ +        
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1825

Query: 532  DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
                   + E E+E   + A D     +  +E     ++++EE    ++ AS S   R  
Sbjct: 1826 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1878

Query: 589  PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
                D+  +    + E     ++ E A    ++   EL       +  L  +E  E+E  
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
             Q    A+ E +    +E  +  L    E   Q  A  L E        EE  + + +  
Sbjct: 1939 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 1997

Query: 706  EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
            +ES  Q++                      LA  A       +E A   + ++ +Q +Q+
Sbjct: 1998 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2035

Query: 766  TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
              TL++++++           D ++G+ EAA    A    EA ++A +  A+     EE 
Sbjct: 2036 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2081

Query: 826  TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
                      ER  + A E    R   +  ++ + + A ++A   ++ E    +      
Sbjct: 2082 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132

Query: 886  LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
             E +K     EQ L +KA +  E   L L   E  H+   L E     + EA E     S
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192

Query: 941  DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
             V E      + +E+   ++            R+  + +  L  +E A++ K+V     R
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2250

Query: 994  LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
            LS    EA   R    E   ++ +LA       E +  E+M    EA R     E+L ++
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2303

Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
             +LA+E+          R+   ++E++ +  A   E+    ++ L+AE  + + E+ AE 
Sbjct: 2304 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2350

Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
            E  K    EM S A+  A  +A         +GE   +  +    + T    ++LE I  
Sbjct: 2351 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2406

Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
             + +   ERL EA     +++E+L                E  L   ++E    VQ  E 
Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2451

Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
            L+  T   ++    + DS    E   E Q    +    Q+ VA+   +  E+ R++   E
Sbjct: 2452 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510

Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
               +      EE +    E E    R  E    +E +   Q+ E +        E L   
Sbjct: 2511 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2569

Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
             E    A    E +  S+ A  KT+ N   +     AE E  H  D L  K +A     A
Sbjct: 2570 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2629

Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
            G +  EEL R  +     +E+
Sbjct: 2630 GILSAEELQRLAQGHTTVDEL 2650



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)

Query: 414  KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
            K+++ +  EEL+ +AE   R+ R+  + +  +++    +   SA+   Q  +    E   
Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1558

Query: 471  AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
             +E    +       L ++ E   + + E     E+ E + E+   K+NE  +  +Q   
Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618

Query: 526  IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
            + Q          + EK+ E + +   +AR   K E     + EL E + + +   +  +
Sbjct: 1619 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672

Query: 586  RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
                 +++ E            ++   E  R+   +EL+   +   +     + LE E+ 
Sbjct: 1673 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
                 +A++E   +      E   +  +EK  Q + AE      L+E++ +  +  E+ K
Sbjct: 1727 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782

Query: 700  DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
             + +L EE  A+           +    + +    + A+G  T      E A      E+
Sbjct: 1783 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831

Query: 760  QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
            ++L +       +    E++A QH+ ADI +   +     ++    +  L   + T  Q 
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1888

Query: 820  ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
               EE  E   +    E+ A G AE E    LG   S+      +K+   L   EA  ++
Sbjct: 1889 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1941

Query: 880  ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
             L     E ++   E E+ ++K++ A E AA   +     AAL E    +  + E    +
Sbjct: 1942 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 1992

Query: 940  SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
             +  E E    + L      ++ A KR    E+A     ++  +E ++ ++ E   L   
Sbjct: 1993 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047

Query: 998  TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
             GEAEA+R    E   EE  +  E    +E  +    V EAE  ++   ++        A
Sbjct: 2048 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2093

Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            + R +A+     LRK ++E+E   RA A  ++ A +++Q   A + E E   +  E+T  
Sbjct: 2094 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2147

Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
               ++  +      ++  E      LL E+   LK             E+ L       E
Sbjct: 2148 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206

Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
             ++ L+     E R    RD ++  R      E   +K+   +    ++AA EA    ++
Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264

Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
             A E L      AE++  +   +      L+  AE       +L+ Q+ +A+E     ++
Sbjct: 2265 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2316

Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
             +E+   +  EE +  + TLE E  +      + +                E + Q    
Sbjct: 2317 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376

Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
                      + E     +V  V+ L    + ++  AE  RE +A  E  +EK +  +A 
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2435

Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
                 +EE    QQ++L+ +T A  +  + E
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2466



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
            +S+++   E   + + A  + R+ RE       E +  K+  + + +A++ K  L+EV  
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 1979

Query: 471  AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
              E + +K +  + + E  +QE+  + +  ++      +  EK++    A  Q     Q 
Sbjct: 1980 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2035

Query: 530  PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
             L  ++  LD  + E+E + + A +A +  V+ E +        E+ + +K ++   +++
Sbjct: 2036 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095

Query: 588  HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
               +  + ++     ++EA   +  +++A R      +E +K +K     L  +  +E E
Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155

Query: 644  IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
            +    +   + + +   +DE  + +  E TE   Q  ++   E     V  EE  K K++
Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2214

Query: 704  LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
            +  E+ A + +DK      L+E  +    +A   A     ++    E A +    E    
Sbjct: 2215 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2270

Query: 763  VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
             Q+   L +K   E+ +A Q    +  + K EA L  +   + +   R  +   EQ  +A
Sbjct: 2271 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2322

Query: 823  EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
            ++  E+ +       G +   EAE  R+L                     + + E + L 
Sbjct: 2323 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2354

Query: 883  LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
            L V E  +A +  E+  ++     +A  +  E LH      E AT E+      + +   
Sbjct: 2355 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2407

Query: 943  GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
             +S+ +A    E    +E    K +  ++   L  EE    ++E +  ET+         
Sbjct: 2408 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2458

Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
               +Q S  S ++  L +E F+ +E  + E++    V +A+  RE+ +++    E +  R
Sbjct: 2459 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2515

Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
                    RR+    +  +R+   E +++ +    ++E   +E Q+L+ +    E + RA
Sbjct: 2516 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2575

Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
                        S+    + V A++   N    G D+L     P  EA P  E S +   
Sbjct: 2576 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2615

Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
             LR++   +RL EA          LS+ E + L +GH
Sbjct: 2616 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2644



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)

Query: 886  LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
            +E ++  +E ++  E+  LA   AAL  +     A  +  A +E    E    + +    
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371

Query: 946  EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
             EEA++D +       E+    R+    E      +     +  +R E  +     + EA
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1431

Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
            +  Q      E  +L   A    E+ E ++   + EA R   R+++     D ++ +R+A
Sbjct: 1432 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1481

Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
            E    S  K ++E  RE+     AL       EE +L+AEE E    + EV    + +  
Sbjct: 1482 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1534

Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
                   AE E   + +  ++    L E SL+E  V + +     E+  +      ++  
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1587

Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
             ER   AR+   ++ E    + N AL+   +      + +LA  EAE   + +  E    
Sbjct: 1588 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1642

Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
              G+AEE A +  +     LE + +   G       Q+ +A E  ++  +   E  ++  
Sbjct: 1643 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1697

Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
            +  E++   L+ EA        + + E      + E +   +  A E       T+E + 
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1754

Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
            +  E  AG       E A  + +A +A     +AEE+   Q+       A A +V+ E+L
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1807

Query: 1409 ARSGE 1413
            A  GE
Sbjct: 1808 AAIGE 1812



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)

Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
            EE    AE  R ++R+ +   E++ A E+++      +  K  +ERE       +++E  
Sbjct: 1313 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370

Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
             +EE  + A++ +   +   ++  ++      S+AE +A    +E ++   L  E+ ++ 
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1424

Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
              + + EAT     G E  L+ + A  +E   ++     + E   R+             
Sbjct: 1425 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483

Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
            EL+SR   E  A +E  R            ++ E  L   E E A +VQ        + +
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543

Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
            AE     A   +  A LE   + +      LR +     +    AE+ REEA  E    +
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603

Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
                  L      +  ++     + E   QK E        A       G+  E A  +R
Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1655

Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
            E LA  E  +++ +A   +     AE+E    + E   +     +++ EELAR   E  A
Sbjct: 1656 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1713

Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
            A +       E        +E   +   + +EE    SE  +    +  GR    A E  
Sbjct: 1714 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1772

Query: 1475 RL-GLSREGERE 1485
            RL  L+ E +R+
Sbjct: 1773 RLRALAEEAKRQ 1784



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)

Query: 800  EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
            E   VH   L   K  A   E A+   E+++    +E   +G    +AEAE V  L E  
Sbjct: 968  ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025

Query: 856  -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
             + P  ++  +  +G   ++     A+ L  L+T      G QG E+ + A+E       
Sbjct: 1026 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1084

Query: 908  AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            A    L  L    A+L++     E +     A+ D     +E    L+      D   +R
Sbjct: 1085 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1144

Query: 967  --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
              E  ++     +A+L   +  +   E +  + R        L  +  +A   + Q+   
Sbjct: 1145 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1204

Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
              ++       L +E  L +E     E V E +   +     I   EL L   + + E  
Sbjct: 1205 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1264

Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
             +  +K      ++S  +E         E      Q +K     +ET  R EEE +    
Sbjct: 1265 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1321

Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
            +   + E  A VEA+                            EK    +     +   +
Sbjct: 1322 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1353

Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
               EA++ + + +EE+  RE  A+     K   +++ +    + EAE   K +  E    
Sbjct: 1354 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1413

Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
            +  + EE   +       LE     +GG +  L+   A AEE      + +EEA  +   
Sbjct: 1414 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470

Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
             ++E  ++   E E      +E +   E +   Q           A+E L    E AE  
Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1519

Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
              +      R+V    ETA+   E  + +K +SF++   +     Q+E V    A  +  
Sbjct: 1520 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1577

Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
             E  A+   E   A E          +    AL      L  + EE ++ +  A    + 
Sbjct: 1578 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1632

Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
            ++E    E  R G + E    +REL+ + L+    L
Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1668



 Score = 37.7 bits (86), Expect = 0.086
 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)

Query: 457  SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
            SA+   TG K+  +       +      +L+D     L+ +      +D E+      E 
Sbjct: 3974 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4033

Query: 513  SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
            + + G  D +MN I   P DD K   DP  E   +  +  +    + D   G     L+E
Sbjct: 4034 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4091

Query: 573  DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
             K++ KT+S +S R             + D E   + S  E+ R+             ++
Sbjct: 4092 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4135

Query: 633  HLPIEESLEIEIEDQEITKADVETKPMPID 662
            +L + E  E E E+  I+ +D   K M ID
Sbjct: 4136 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4164


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)

Query: 417  STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
            +T+K +EL+    KVR E E ++  +   +E   S S K   + E + G    L E    
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1942

Query: 472  VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
            +  +  + K  +++ E+D     + E E          GE +  + +A++ +        
Sbjct: 1943 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1994

Query: 532  DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
                   + E E+E   + A D     +  +E     ++++EE    ++ AS S   R  
Sbjct: 1995 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 2047

Query: 589  PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
                D+  +    + E     ++ E A    ++   EL       +  L  +E  E+E  
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
             Q    A+ E +    +E  +  L    E   Q  A  L E        EE  + + +  
Sbjct: 2108 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2166

Query: 706  EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
            +ES  Q++                      LA  A       +E A   + ++ +Q +Q+
Sbjct: 2167 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2204

Query: 766  TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
              TL++++++           D ++G+ EAA    A    EA ++A +  A+     EE 
Sbjct: 2205 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2250

Query: 826  TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
                      ER  + A E    R   +  ++ + + A ++A   ++ E    +      
Sbjct: 2251 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301

Query: 886  LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
             E +K     EQ L +KA +  E   L L   E  H+   L E     + EA E     S
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361

Query: 941  DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
             V E      + +E+   ++            R+  + +  L  +E A++ K+V     R
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2419

Query: 994  LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
            LS    EA   R    E   ++ +LA       E +  E+M    EA R     E+L ++
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2472

Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
             +LA+E+          R+   ++E++ +  A   E+    ++ L+AE  + + E+ AE 
Sbjct: 2473 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2519

Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
            E  K    EM S A+  A  +A         +GE   +  +    + T    ++LE I  
Sbjct: 2520 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2575

Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
             + +   ERL EA     +++E+L                E  L   ++E    VQ  E 
Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2620

Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
            L+  T   ++    + DS    E   E Q    +    Q+ VA+   +  E+ R++   E
Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679

Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
               +      EE +    E E    R  E    +E +   Q+ E +        E L   
Sbjct: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2738

Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
             E    A    E +  S+ A  KT+ N   +     AE E  H  D L  K +A     A
Sbjct: 2739 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2798

Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
            G +  EEL R  +     +E+
Sbjct: 2799 GILSAEELQRLAQGHTTVDEL 2819



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)

Query: 414  KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
            K+++ +  EEL+ +AE   R+ R+  + +  +++    +   SA+   Q  +    E   
Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1727

Query: 471  AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
             +E    +       L ++ E   + + E     E+ E + E+   K+NE  +  +Q   
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787

Query: 526  IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
            + Q          + EK+ E + +   +AR   K E     + EL E + + +   +  +
Sbjct: 1788 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841

Query: 586  RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
                 +++ E            ++   E  R+   +EL+   +   +     + LE E+ 
Sbjct: 1842 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
                 +A++E   +      E   +  +EK  Q + AE      L+E++ +  +  E+ K
Sbjct: 1896 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951

Query: 700  DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
             + +L EE  A+           +    + +    + A+G  T      E A      E+
Sbjct: 1952 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000

Query: 760  QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
            ++L +       +    E++A QH+ ADI +   +     ++    +  L   + T  Q 
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 2057

Query: 820  ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
               EE  E   +    E+ A G AE E    LG   S+      +K+   L   EA  ++
Sbjct: 2058 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 2110

Query: 880  ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
             L     E ++   E E+ ++K++ A E AA   +     AAL E    +  + E    +
Sbjct: 2111 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2161

Query: 940  SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
             +  E E    + L      ++ A KR    E+A     ++  +E ++ ++ E   L   
Sbjct: 2162 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216

Query: 998  TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
             GEAEA+R    E   EE  +  E    +E  +    V EAE  ++   ++        A
Sbjct: 2217 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2262

Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            + R +A+     LRK ++E+E   RA A  ++ A +++Q   A + E E   +  E+T  
Sbjct: 2263 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2316

Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
               ++  +      ++  E      LL E+   LK             E+ L       E
Sbjct: 2317 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375

Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
             ++ L+     E R    RD ++  R      E   +K+   +    ++AA EA    ++
Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2433

Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
             A E L      AE++  +   +      L+  AE       +L+ Q+ +A+E     ++
Sbjct: 2434 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2485

Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
             +E+   +  EE +  + TLE E  +      + +                E + Q    
Sbjct: 2486 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545

Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
                      + E     +V  V+ L    + ++  AE  RE +A  E  +EK +  +A 
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2604

Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
                 +EE    QQ++L+ +T A  +  + E
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2635



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
            +S+++   E   + + A  + R+ RE       E +  K+  + + +A++ K  L+EV  
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2148

Query: 471  AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
              E + +K +  + + E  +QE+  + +  ++      +  EK++    A  Q     Q 
Sbjct: 2149 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2204

Query: 530  PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
             L  ++  LD  + E+E + + A +A +  V+ E +        E+ + +K ++   +++
Sbjct: 2205 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264

Query: 588  HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
               +  + ++     ++EA   +  +++A R      +E +K +K     L  +  +E E
Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324

Query: 644  IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
            +    +   + + +   +DE  + +  E TE   Q  ++   E     V  EE  K K++
Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2383

Query: 704  LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
            +  E+ A + +DK      L+E  +    +A   A     ++    E A +    E    
Sbjct: 2384 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2439

Query: 763  VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
             Q+   L +K   E+ +A Q    +  + K EA L  +   + +   R  +   EQ  +A
Sbjct: 2440 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2491

Query: 823  EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
            ++  E+ +       G +   EAE  R+L                     + + E + L 
Sbjct: 2492 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2523

Query: 883  LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
            L V E  +A +  E+  ++     +A  +  E LH      E AT E+      + +   
Sbjct: 2524 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2576

Query: 943  GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
             +S+ +A    E    +E    K +  ++   L  EE    ++E +  ET+         
Sbjct: 2577 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2627

Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
               +Q S  S ++  L +E F+ +E  + E++    V +A+  RE+ +++    E +  R
Sbjct: 2628 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2684

Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
                    RR+    +  +R+   E +++ +    ++E   +E Q+L+ +    E + RA
Sbjct: 2685 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2744

Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
                        S+    + V A++   N    G D+L     P  EA P  E S +   
Sbjct: 2745 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2784

Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
             LR++   +RL EA          LS+ E + L +GH
Sbjct: 2785 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2813



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)

Query: 886  LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
            +E ++  +E ++  E+  LA   AAL  +     A  +  A +E    E    + +    
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540

Query: 946  EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
             EEA++D +       E+    R+    E      +     +  +R E  +     + EA
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1600

Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
            +  Q      E  +L   A    E+ E ++   + EA R   R+++     D ++ +R+A
Sbjct: 1601 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1650

Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
            E    S  K ++E  RE+     AL       EE +L+AEE E    + EV    + +  
Sbjct: 1651 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1703

Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
                   AE E   + +  ++    L E SL+E  V + +     E+  +      ++  
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1756

Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
             ER   AR+   ++ E    + N AL+   +      + +LA  EAE   + +  E    
Sbjct: 1757 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1811

Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
              G+AEE A +  +     LE + +   G       Q+ +A E  ++  +   E  ++  
Sbjct: 1812 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1866

Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
            +  E++   L+ EA        + + E      + E +   +  A E       T+E + 
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1923

Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
            +  E  AG       E A  + +A +A     +AEE+   Q+       A A +V+ E+L
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1976

Query: 1409 ARSGE 1413
            A  GE
Sbjct: 1977 AAIGE 1981



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)

Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
            EE    AE  R ++R+ +   E++ A E+++      +  K  +ERE       +++E  
Sbjct: 1482 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539

Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
             +EE  + A++ +   +   ++  ++      S+AE +A    +E ++   L  E+ ++ 
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1593

Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
              + + EAT     G E  L+ + A  +E   ++     + E   R+             
Sbjct: 1594 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652

Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
            EL+SR   E  A +E  R            ++ E  L   E E A +VQ        + +
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712

Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
            AE     A   +  A LE   + +      LR +     +    AE+ REEA  E    +
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772

Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
                  L      +  ++     + E   QK E        A       G+  E A  +R
Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1824

Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
            E LA  E  +++ +A   +     AE+E    + E   +     +++ EELAR   E  A
Sbjct: 1825 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1882

Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
            A +       E        +E   +   + +EE    SE  +    +  GR    A E  
Sbjct: 1883 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1941

Query: 1475 RL-GLSREGERE 1485
            RL  L+ E +R+
Sbjct: 1942 RLRALAEEAKRQ 1953



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)

Query: 800  EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
            E   VH   L   K  A   E A+   E+++    +E   +G    +AEAE V  L E  
Sbjct: 1137 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194

Query: 856  -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
             + P  ++  +  +G   ++     A+ L  L+T      G QG E+ + A+E       
Sbjct: 1195 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1253

Query: 908  AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            A    L  L    A+L++     E +     A+ D     +E    L+      D   +R
Sbjct: 1254 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1313

Query: 967  --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
              E  ++     +A+L   +  +   E +  + R        L  +  +A   + Q+   
Sbjct: 1314 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373

Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
              ++       L +E  L +E     E V E +   +     I   EL L   + + E  
Sbjct: 1374 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1433

Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
             +  +K      ++S  +E         E      Q +K     +ET  R EEE +    
Sbjct: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1490

Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
            +   + E  A VEA+                            EK    +     +   +
Sbjct: 1491 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1522

Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
               EA++ + + +EE+  RE  A+     K   +++ +    + EAE   K +  E    
Sbjct: 1523 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1582

Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
            +  + EE   +       LE     +GG +  L+   A AEE      + +EEA  +   
Sbjct: 1583 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639

Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
             ++E  ++   E E      +E +   E +   Q           A+E L    E AE  
Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1688

Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
              +      R+V    ETA+   E  + +K +SF++   +     Q+E V    A  +  
Sbjct: 1689 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1746

Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
             E  A+   E   A E          +    AL      L  + EE ++ +  A    + 
Sbjct: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1801

Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
            ++E    E  R G + E    +REL+ + L+    L
Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1837



 Score = 37.7 bits (86), Expect = 0.086
 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)

Query: 457  SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
            SA+   TG K+  +       +      +L+D     L+ +      +D E+      E 
Sbjct: 4143 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4202

Query: 513  SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
            + + G  D +MN I   P DD K   DP  E   +  +  +    + D   G     L+E
Sbjct: 4203 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4260

Query: 573  DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
             K++ KT+S +S R             + D E   + S  E+ R+             ++
Sbjct: 4261 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4304

Query: 633  HLPIEESLEIEIEDQEITKADVETKPMPID 662
            +L + E  E E E+  I+ +D   K M ID
Sbjct: 4305 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4333


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)

Query: 417  STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
            +T+K +EL+    KVR E E ++  +   +E   S S K   + E + G    L E    
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783

Query: 472  VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
            +  +  + K  +++ E+D     + E E          GE +  + +A++ +        
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1835

Query: 532  DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
                   + E E+E   + A D     +  +E     ++++EE    ++ AS S   R  
Sbjct: 1836 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1888

Query: 589  PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
                D+  +    + E     ++ E A    ++   EL       +  L  +E  E+E  
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
             Q    A+ E +    +E  +  L    E   Q  A  L E        EE  + + +  
Sbjct: 1949 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2007

Query: 706  EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
            +ES  Q++                      LA  A       +E A   + ++ +Q +Q+
Sbjct: 2008 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2045

Query: 766  TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
              TL++++++           D ++G+ EAA    A    EA ++A +  A+     EE 
Sbjct: 2046 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2091

Query: 826  TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
                      ER  + A E    R   +  ++ + + A ++A   ++ E    +      
Sbjct: 2092 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142

Query: 886  LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
             E +K     EQ L +KA +  E   L L   E  H+   L E     + EA E     S
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202

Query: 941  DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
             V E      + +E+   ++            R+  + +  L  +E A++ K+V     R
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2260

Query: 994  LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
            LS    EA   R    E   ++ +LA       E +  E+M    EA R     E+L ++
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2313

Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
             +LA+E+          R+   ++E++ +  A   E+    ++ L+AE  + + E+ AE 
Sbjct: 2314 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2360

Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
            E  K    EM S A+  A  +A         +GE   +  +    + T    ++LE I  
Sbjct: 2361 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2416

Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
             + +   ERL EA     +++E+L                E  L   ++E    VQ  E 
Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2461

Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
            L+  T   ++    + DS    E   E Q    +    Q+ VA+   +  E+ R++   E
Sbjct: 2462 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520

Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
               +      EE +    E E    R  E    +E +   Q+ E +        E L   
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2579

Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
             E    A    E +  S+ A  KT+ N   +     AE E  H  D L  K +A     A
Sbjct: 2580 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2639

Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
            G +  EEL R  +     +E+
Sbjct: 2640 GILSAEELQRLAQGHTTVDEL 2660



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)

Query: 414  KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
            K+++ +  EEL+ +AE   R+ R+  + +  +++    +   SA+   Q  +    E   
Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1568

Query: 471  AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
             +E    +       L ++ E   + + E     E+ E + E+   K+NE  +  +Q   
Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628

Query: 526  IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
            + Q          + EK+ E + +   +AR   K E     + EL E + + +   +  +
Sbjct: 1629 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682

Query: 586  RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
                 +++ E            ++   E  R+   +EL+   +   +     + LE E+ 
Sbjct: 1683 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
                 +A++E   +      E   +  +EK  Q + AE      L+E++ +  +  E+ K
Sbjct: 1737 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792

Query: 700  DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
             + +L EE  A+           +    + +    + A+G  T      E A      E+
Sbjct: 1793 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841

Query: 760  QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
            ++L +       +    E++A QH+ ADI +   +     ++    +  L   + T  Q 
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1898

Query: 820  ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
               EE  E   +    E+ A G AE E    LG   S+      +K+   L   EA  ++
Sbjct: 1899 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1951

Query: 880  ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
             L     E ++   E E+ ++K++ A E AA   +     AAL E    +  + E    +
Sbjct: 1952 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2002

Query: 940  SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
             +  E E    + L      ++ A KR    E+A     ++  +E ++ ++ E   L   
Sbjct: 2003 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057

Query: 998  TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
             GEAEA+R    E   EE  +  E    +E  +    V EAE  ++   ++        A
Sbjct: 2058 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2103

Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            + R +A+     LRK ++E+E   RA A  ++ A +++Q   A + E E   +  E+T  
Sbjct: 2104 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2157

Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
               ++  +      ++  E      LL E+   LK             E+ L       E
Sbjct: 2158 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216

Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
             ++ L+     E R    RD ++  R      E   +K+   +    ++AA EA    ++
Sbjct: 2217 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2274

Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
             A E L      AE++  +   +      L+  AE       +L+ Q+ +A+E     ++
Sbjct: 2275 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2326

Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
             +E+   +  EE +  + TLE E  +      + +                E + Q    
Sbjct: 2327 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386

Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
                      + E     +V  V+ L    + ++  AE  RE +A  E  +EK +  +A 
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2445

Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
                 +EE    QQ++L+ +T A  +  + E
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2476



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
            +S+++   E   + + A  + R+ RE       E +  K+  + + +A++ K  L+EV  
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 1989

Query: 471  AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
              E + +K +  + + E  +QE+  + +  ++      +  EK++    A  Q     Q 
Sbjct: 1990 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2045

Query: 530  PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
             L  ++  LD  + E+E + + A +A +  V+ E +        E+ + +K ++   +++
Sbjct: 2046 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2105

Query: 588  HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
               +  + ++     ++EA   +  +++A R      +E +K +K     L  +  +E E
Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165

Query: 644  IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
            +    +   + + +   +DE  + +  E TE   Q  ++   E     V  EE  K K++
Sbjct: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2224

Query: 704  LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
            +  E+ A + +DK      L+E  +    +A   A     ++    E A +    E    
Sbjct: 2225 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2280

Query: 763  VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
             Q+   L +K   E+ +A Q    +  + K EA L  +   + +   R  +   EQ  +A
Sbjct: 2281 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2332

Query: 823  EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
            ++  E+ +       G +   EAE  R+L                     + + E + L 
Sbjct: 2333 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2364

Query: 883  LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
            L V E  +A +  E+  ++     +A  +  E LH      E AT E+      + +   
Sbjct: 2365 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2417

Query: 943  GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
             +S+ +A    E    +E    K +  ++   L  EE    ++E +  ET+         
Sbjct: 2418 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2468

Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
               +Q S  S ++  L +E F+ +E  + E++    V +A+  RE+ +++    E +  R
Sbjct: 2469 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2525

Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
                    RR+    +  +R+   E +++ +    ++E   +E Q+L+ +    E + RA
Sbjct: 2526 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2585

Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
                        S+    + V A++   N    G D+L     P  EA P  E S +   
Sbjct: 2586 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2625

Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
             LR++   +RL EA          LS+ E + L +GH
Sbjct: 2626 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2654



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)

Query: 886  LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
            +E ++  +E ++  E+  LA   AAL  +     A  +  A +E    E    + +    
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381

Query: 946  EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
             EEA++D +       E+    R+    E      +     +  +R E  +     + EA
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1441

Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
            +  Q      E  +L   A    E+ E ++   + EA R   R+++     D ++ +R+A
Sbjct: 1442 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1491

Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
            E    S  K ++E  RE+     AL       EE +L+AEE E    + EV    + +  
Sbjct: 1492 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1544

Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
                   AE E   + +  ++    L E SL+E  V + +     E+  +      ++  
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1597

Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
             ER   AR+   ++ E    + N AL+   +      + +LA  EAE   + +  E    
Sbjct: 1598 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1652

Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
              G+AEE A +  +     LE + +   G       Q+ +A E  ++  +   E  ++  
Sbjct: 1653 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1707

Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
            +  E++   L+ EA        + + E      + E +   +  A E       T+E + 
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1764

Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
            +  E  AG       E A  + +A +A     +AEE+   Q+       A A +V+ E+L
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1817

Query: 1409 ARSGE 1413
            A  GE
Sbjct: 1818 AAIGE 1822



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)

Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
            EE    AE  R ++R+ +   E++ A E+++      +  K  +ERE       +++E  
Sbjct: 1323 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380

Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
             +EE  + A++ +   +   ++  ++      S+AE +A    +E ++   L  E+ ++ 
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1434

Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
              + + EAT     G E  L+ + A  +E   ++     + E   R+             
Sbjct: 1435 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493

Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
            EL+SR   E  A +E  R            ++ E  L   E E A +VQ        + +
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553

Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
            AE     A   +  A LE   + +      LR +     +    AE+ REEA  E    +
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613

Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
                  L      +  ++     + E   QK E        A       G+  E A  +R
Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1665

Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
            E LA  E  +++ +A   +     AE+E    + E   +     +++ EELAR   E  A
Sbjct: 1666 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1723

Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
            A +       E        +E   +   + +EE    SE  +    +  GR    A E  
Sbjct: 1724 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1782

Query: 1475 RL-GLSREGERE 1485
            RL  L+ E +R+
Sbjct: 1783 RLRALAEEAKRQ 1794



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)

Query: 800  EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
            E   VH   L   K  A   E A+   E+++    +E   +G    +AEAE V  L E  
Sbjct: 978  ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035

Query: 856  -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
             + P  ++  +  +G   ++     A+ L  L+T      G QG E+ + A+E       
Sbjct: 1036 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1094

Query: 908  AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            A    L  L    A+L++     E +     A+ D     +E    L+      D   +R
Sbjct: 1095 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1154

Query: 967  --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
              E  ++     +A+L   +  +   E +  + R        L  +  +A   + Q+   
Sbjct: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214

Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
              ++       L +E  L +E     E V E +   +     I   EL L   + + E  
Sbjct: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1274

Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
             +  +K      ++S  +E         E      Q +K     +ET  R EEE +    
Sbjct: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1331

Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
            +   + E  A VEA+                            EK    +     +   +
Sbjct: 1332 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1363

Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
               EA++ + + +EE+  RE  A+     K   +++ +    + EAE   K +  E    
Sbjct: 1364 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1423

Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
            +  + EE   +       LE     +GG +  L+   A AEE      + +EEA  +   
Sbjct: 1424 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480

Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
             ++E  ++   E E      +E +   E +   Q           A+E L    E AE  
Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1529

Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
              +      R+V    ETA+   E  + +K +SF++   +     Q+E V    A  +  
Sbjct: 1530 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1587

Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
             E  A+   E   A E          +    AL      L  + EE ++ +  A    + 
Sbjct: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1642

Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
            ++E    E  R G + E    +REL+ + L+    L
Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1678



 Score = 37.7 bits (86), Expect = 0.086
 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)

Query: 457  SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
            SA+   TG K+  +       +      +L+D     L+ +      +D E+      E 
Sbjct: 3984 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4043

Query: 513  SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
            + + G  D +MN I   P DD K   DP  E   +  +  +    + D   G     L+E
Sbjct: 4044 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4101

Query: 573  DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
             K++ KT+S +S R             + D E   + S  E+ R+             ++
Sbjct: 4102 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4145

Query: 633  HLPIEESLEIEIEDQEITKADVETKPMPID 662
            +L + E  E E E+  I+ +D   K M ID
Sbjct: 4146 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4174


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)

Query: 417  STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
            +T+K +EL+    KVR E E ++  +   +E   S S K   + E + G    L E    
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1791

Query: 472  VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
            +  +  + K  +++ E+D     + E E          GE +  + +A++ +        
Sbjct: 1792 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1843

Query: 532  DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
                   + E E+E   + A D     +  +E     ++++EE    ++ AS S   R  
Sbjct: 1844 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1896

Query: 589  PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
                D+  +    + E     ++ E A    ++   EL       +  L  +E  E+E  
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
             Q    A+ E +    +E  +  L    E   Q  A  L E        EE  + + +  
Sbjct: 1957 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2015

Query: 706  EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
            +ES  Q++                      LA  A       +E A   + ++ +Q +Q+
Sbjct: 2016 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2053

Query: 766  TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
              TL++++++           D ++G+ EAA    A    EA ++A +  A+     EE 
Sbjct: 2054 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2099

Query: 826  TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
                      ER  + A E    R   +  ++ + + A ++A   ++ E    +      
Sbjct: 2100 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150

Query: 886  LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
             E +K     EQ L +KA +  E   L L   E  H+   L E     + EA E     S
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210

Query: 941  DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
             V E      + +E+   ++            R+  + +  L  +E A++ K+V     R
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2268

Query: 994  LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
            LS    EA   R    E   ++ +LA       E +  E+M    EA R     E+L ++
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2321

Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
             +LA+E+          R+   ++E++ +  A   E+    ++ L+AE  + + E+ AE 
Sbjct: 2322 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2368

Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
            E  K    EM S A+  A  +A         +GE   +  +    + T    ++LE I  
Sbjct: 2369 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2424

Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
             + +   ERL EA     +++E+L                E  L   ++E    VQ  E 
Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2469

Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
            L+  T   ++    + DS    E   E Q    +    Q+ VA+   +  E+ R++   E
Sbjct: 2470 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528

Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
               +      EE +    E E    R  E    +E +   Q+ E +        E L   
Sbjct: 2529 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2587

Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
             E    A    E +  S+ A  KT+ N   +     AE E  H  D L  K +A     A
Sbjct: 2588 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2647

Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
            G +  EEL R  +     +E+
Sbjct: 2648 GILSAEELQRLAQGHTTVDEL 2668



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)

Query: 414  KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
            K+++ +  EEL+ +AE   R+ R+  + +  +++    +   SA+   Q  +    E   
Sbjct: 1517 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1576

Query: 471  AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
             +E    +       L ++ E   + + E     E+ E + E+   K+NE  +  +Q   
Sbjct: 1577 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636

Query: 526  IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
            + Q          + EK+ E + +   +AR   K E     + EL E + + +   +  +
Sbjct: 1637 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690

Query: 586  RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
                 +++ E            ++   E  R+   +EL+   +   +     + LE E+ 
Sbjct: 1691 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
                 +A++E   +      E   +  +EK  Q + AE      L+E++ +  +  E+ K
Sbjct: 1745 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800

Query: 700  DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
             + +L EE  A+           +    + +    + A+G  T      E A      E+
Sbjct: 1801 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849

Query: 760  QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
            ++L +       +    E++A QH+ ADI +   +     ++    +  L   + T  Q 
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1906

Query: 820  ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
               EE  E   +    E+ A G AE E    LG   S+      +K+   L   EA  ++
Sbjct: 1907 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1959

Query: 880  ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
             L     E ++   E E+ ++K++ A E AA   +     AAL E    +  + E    +
Sbjct: 1960 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2010

Query: 940  SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
             +  E E    + L      ++ A KR    E+A     ++  +E ++ ++ E   L   
Sbjct: 2011 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2065

Query: 998  TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
             GEAEA+R    E   EE  +  E    +E  +    V EAE  ++   ++        A
Sbjct: 2066 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2111

Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            + R +A+     LRK ++E+E   RA A  ++ A +++Q   A + E E   +  E+T  
Sbjct: 2112 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2165

Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
               ++  +      ++  E      LL E+   LK             E+ L       E
Sbjct: 2166 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2224

Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
             ++ L+     E R    RD ++  R      E   +K+   +    ++AA EA    ++
Sbjct: 2225 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2282

Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
             A E L      AE++  +   +      L+  AE       +L+ Q+ +A+E     ++
Sbjct: 2283 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2334

Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
             +E+   +  EE +  + TLE E  +      + +                E + Q    
Sbjct: 2335 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394

Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
                      + E     +V  V+ L    + ++  AE  RE +A  E  +EK +  +A 
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2453

Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
                 +EE    QQ++L+ +T A  +  + E
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2484



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
            +S+++   E   + + A  + R+ RE       E +  K+  + + +A++ K  L+EV  
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 1997

Query: 471  AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
              E + +K +  + + E  +QE+  + +  ++      +  EK++    A  Q     Q 
Sbjct: 1998 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2053

Query: 530  PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
             L  ++  LD  + E+E + + A +A +  V+ E +        E+ + +K ++   +++
Sbjct: 2054 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2113

Query: 588  HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
               +  + ++     ++EA   +  +++A R      +E +K +K     L  +  +E E
Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2173

Query: 644  IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
            +    +   + + +   +DE  + +  E TE   Q  ++   E     V  EE  K K++
Sbjct: 2174 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2232

Query: 704  LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
            +  E+ A + +DK      L+E  +    +A   A     ++    E A +    E    
Sbjct: 2233 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2288

Query: 763  VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
             Q+   L +K   E+ +A Q    +  + K EA L  +   + +   R  +   EQ  +A
Sbjct: 2289 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2340

Query: 823  EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
            ++  E+ +       G +   EAE  R+L                     + + E + L 
Sbjct: 2341 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2372

Query: 883  LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
            L V E  +A +  E+  ++     +A  +  E LH      E AT E+      + +   
Sbjct: 2373 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2425

Query: 943  GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
             +S+ +A    E    +E    K +  ++   L  EE    ++E +  ET+         
Sbjct: 2426 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2476

Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
               +Q S  S ++  L +E F+ +E  + E++    V +A+  RE+ +++    E +  R
Sbjct: 2477 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2533

Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
                    RR+    +  +R+   E +++ +    ++E   +E Q+L+ +    E + RA
Sbjct: 2534 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2593

Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
                        S+    + V A++   N    G D+L     P  EA P  E S +   
Sbjct: 2594 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2633

Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
             LR++   +RL EA          LS+ E + L +GH
Sbjct: 2634 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2662



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)

Query: 886  LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
            +E ++  +E ++  E+  LA   AAL  +     A  +  A +E    E    + +    
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389

Query: 946  EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
             EEA++D +       E+    R+    E      +     +  +R E  +     + EA
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1449

Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
            +  Q      E  +L   A    E+ E ++   + EA R   R+++     D ++ +R+A
Sbjct: 1450 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1499

Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
            E    S  K ++E  RE+     AL       EE +L+AEE E    + EV    + +  
Sbjct: 1500 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1552

Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
                   AE E   + +  ++    L E SL+E  V + +     E+  +      ++  
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1605

Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
             ER   AR+   ++ E    + N AL+   +      + +LA  EAE   + +  E    
Sbjct: 1606 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1660

Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
              G+AEE A +  +     LE + +   G       Q+ +A E  ++  +   E  ++  
Sbjct: 1661 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1715

Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
            +  E++   L+ EA        + + E      + E +   +  A E       T+E + 
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1772

Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
            +  E  AG       E A  + +A +A     +AEE+   Q+       A A +V+ E+L
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1825

Query: 1409 ARSGE 1413
            A  GE
Sbjct: 1826 AAIGE 1830



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)

Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
            EE    AE  R ++R+ +   E++ A E+++      +  K  +ERE       +++E  
Sbjct: 1331 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388

Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
             +EE  + A++ +   +   ++  ++      S+AE +A    +E ++   L  E+ ++ 
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1442

Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
              + + EAT     G E  L+ + A  +E   ++     + E   R+             
Sbjct: 1443 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501

Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
            EL+SR   E  A +E  R            ++ E  L   E E A +VQ        + +
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561

Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
            AE     A   +  A LE   + +      LR +     +    AE+ REEA  E    +
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621

Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
                  L      +  ++     + E   QK E        A       G+  E A  +R
Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1673

Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
            E LA  E  +++ +A   +     AE+E    + E   +     +++ EELAR   E  A
Sbjct: 1674 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1731

Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
            A +       E        +E   +   + +EE    SE  +    +  GR    A E  
Sbjct: 1732 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1790

Query: 1475 RL-GLSREGERE 1485
            RL  L+ E +R+
Sbjct: 1791 RLRALAEEAKRQ 1802



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)

Query: 800  EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
            E   VH   L   K  A   E A+   E+++    +E   +G    +AEAE V  L E  
Sbjct: 986  ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043

Query: 856  -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
             + P  ++  +  +G   ++     A+ L  L+T      G QG E+ + A+E       
Sbjct: 1044 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1102

Query: 908  AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            A    L  L    A+L++     E +     A+ D     +E    L+      D   +R
Sbjct: 1103 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1162

Query: 967  --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
              E  ++     +A+L   +  +   E +  + R        L  +  +A   + Q+   
Sbjct: 1163 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1222

Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
              ++       L +E  L +E     E V E +   +     I   EL L   + + E  
Sbjct: 1223 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1282

Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
             +  +K      ++S  +E         E      Q +K     +ET  R EEE +    
Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1339

Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
            +   + E  A VEA+                            EK    +     +   +
Sbjct: 1340 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1371

Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
               EA++ + + +EE+  RE  A+     K   +++ +    + EAE   K +  E    
Sbjct: 1372 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1431

Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
            +  + EE   +       LE     +GG +  L+   A AEE      + +EEA  +   
Sbjct: 1432 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488

Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
             ++E  ++   E E      +E +   E +   Q           A+E L    E AE  
Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1537

Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
              +      R+V    ETA+   E  + +K +SF++   +     Q+E V    A  +  
Sbjct: 1538 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1595

Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
             E  A+   E   A E          +    AL      L  + EE ++ +  A    + 
Sbjct: 1596 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1650

Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
            ++E    E  R G + E    +REL+ + L+    L
Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1686



 Score = 37.7 bits (86), Expect = 0.086
 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)

Query: 457  SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
            SA+   TG K+  +       +      +L+D     L+ +      +D E+      E 
Sbjct: 3992 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4051

Query: 513  SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
            + + G  D +MN I   P DD K   DP  E   +  +  +    + D   G     L+E
Sbjct: 4052 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4109

Query: 573  DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
             K++ KT+S +S R             + D E   + S  E+ R+             ++
Sbjct: 4110 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4153

Query: 633  HLPIEESLEIEIEDQEITKADVETKPMPID 662
            +L + E  E E E+  I+ +D   K M ID
Sbjct: 4154 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4182


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)

Query: 417  STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
            +T+K +EL+    KVR E E ++  +   +E   S S K   + E + G    L E    
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1832

Query: 472  VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
            +  +  + K  +++ E+D     + E E          GE +  + +A++ +        
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1884

Query: 532  DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
                   + E E+E   + A D     +  +E     ++++EE    ++ AS S   R  
Sbjct: 1885 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1937

Query: 589  PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
                D+  +    + E     ++ E A    ++   EL       +  L  +E  E+E  
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
             Q    A+ E +    +E  +  L    E   Q  A  L E        EE  + + +  
Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2056

Query: 706  EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
            +ES  Q++                      LA  A       +E A   + ++ +Q +Q+
Sbjct: 2057 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2094

Query: 766  TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
              TL++++++           D ++G+ EAA    A    EA ++A +  A+     EE 
Sbjct: 2095 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2140

Query: 826  TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
                      ER  + A E    R   +  ++ + + A ++A   ++ E    +      
Sbjct: 2141 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191

Query: 886  LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
             E +K     EQ L +KA +  E   L L   E  H+   L E     + EA E     S
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251

Query: 941  DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
             V E      + +E+   ++            R+  + +  L  +E A++ K+V     R
Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2309

Query: 994  LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
            LS    EA   R    E   ++ +LA       E +  E+M    EA R     E+L ++
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2362

Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
             +LA+E+          R+   ++E++ +  A   E+    ++ L+AE  + + E+ AE 
Sbjct: 2363 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2409

Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
            E  K    EM S A+  A  +A         +GE   +  +    + T    ++LE I  
Sbjct: 2410 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2465

Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
             + +   ERL EA     +++E+L                E  L   ++E    VQ  E 
Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2510

Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
            L+  T   ++    + DS    E   E Q    +    Q+ VA+   +  E+ R++   E
Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569

Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
               +      EE +    E E    R  E    +E +   Q+ E +        E L   
Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2628

Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
             E    A    E +  S+ A  KT+ N   +     AE E  H  D L  K +A     A
Sbjct: 2629 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2688

Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
            G +  EEL R  +     +E+
Sbjct: 2689 GILSAEELQRLAQGHTTVDEL 2709



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)

Query: 414  KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
            K+++ +  EEL+ +AE   R+ R+  + +  +++    +   SA+   Q  +    E   
Sbjct: 1558 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1617

Query: 471  AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
             +E    +       L ++ E   + + E     E+ E + E+   K+NE  +  +Q   
Sbjct: 1618 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677

Query: 526  IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
            + Q          + EK+ E + +   +AR   K E     + EL E + + +   +  +
Sbjct: 1678 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731

Query: 586  RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
                 +++ E            ++   E  R+   +EL+   +   +     + LE E+ 
Sbjct: 1732 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785

Query: 646  DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
                 +A++E   +      E   +  +EK  Q + AE      L+E++ +  +  E+ K
Sbjct: 1786 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841

Query: 700  DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
             + +L EE  A+           +    + +    + A+G  T      E A      E+
Sbjct: 1842 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890

Query: 760  QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
            ++L +       +    E++A QH+ ADI +   +     ++    +  L   + T  Q 
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1947

Query: 820  ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
               EE  E   +    E+ A G AE E    LG   S+      +K+   L   EA  ++
Sbjct: 1948 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 2000

Query: 880  ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
             L     E ++   E E+ ++K++ A E AA   +     AAL E    +  + E    +
Sbjct: 2001 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2051

Query: 940  SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
             +  E E    + L      ++ A KR    E+A     ++  +E ++ ++ E   L   
Sbjct: 2052 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2106

Query: 998  TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
             GEAEA+R    E   EE  +  E    +E  +    V EAE  ++   ++        A
Sbjct: 2107 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2152

Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            + R +A+     LRK ++E+E   RA A  ++ A +++Q   A + E E   +  E+T  
Sbjct: 2153 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2206

Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
               ++  +      ++  E      LL E+   LK             E+ L       E
Sbjct: 2207 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265

Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
             ++ L+     E R    RD ++  R      E   +K+   +    ++AA EA    ++
Sbjct: 2266 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2323

Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
             A E L      AE++  +   +      L+  AE       +L+ Q+ +A+E     ++
Sbjct: 2324 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2375

Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
             +E+   +  EE +  + TLE E  +      + +                E + Q    
Sbjct: 2376 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435

Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
                      + E     +V  V+ L    + ++  AE  RE +A  E  +EK +  +A 
Sbjct: 2436 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2494

Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
                 +EE    QQ++L+ +T A  +  + E
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2525



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
            +S+++   E   + + A  + R+ RE       E +  K+  + + +A++ K  L+EV  
Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2038

Query: 471  AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
              E + +K +  + + E  +QE+  + +  ++      +  EK++    A  Q     Q 
Sbjct: 2039 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2094

Query: 530  PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
             L  ++  LD  + E+E + + A +A +  V+ E +        E+ + +K ++   +++
Sbjct: 2095 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2154

Query: 588  HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
               +  + ++     ++EA   +  +++A R      +E +K +K     L  +  +E E
Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2214

Query: 644  IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
            +    +   + + +   +DE  + +  E TE   Q  ++   E     V  EE  K K++
Sbjct: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2273

Query: 704  LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
            +  E+ A + +DK      L+E  +    +A   A     ++    E A +    E    
Sbjct: 2274 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2329

Query: 763  VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
             Q+   L +K   E+ +A Q    +  + K EA L  +   + +   R  +   EQ  +A
Sbjct: 2330 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2381

Query: 823  EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
            ++  E+ +       G +   EAE  R+L                     + + E + L 
Sbjct: 2382 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2413

Query: 883  LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
            L V E  +A +  E+  ++     +A  +  E LH      E AT E+      + +   
Sbjct: 2414 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2466

Query: 943  GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
             +S+ +A    E    +E    K +  ++   L  EE    ++E +  ET+         
Sbjct: 2467 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2517

Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
               +Q S  S ++  L +E F+ +E  + E++    V +A+  RE+ +++    E +  R
Sbjct: 2518 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2574

Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
                    RR+    +  +R+   E +++ +    ++E   +E Q+L+ +    E + RA
Sbjct: 2575 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2634

Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
                        S+    + V A++   N    G D+L     P  EA P  E S +   
Sbjct: 2635 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2674

Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
             LR++   +RL EA          LS+ E + L +GH
Sbjct: 2675 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2703



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)

Query: 886  LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
            +E ++  +E ++  E+  LA   AAL  +     A  +  A +E    E    + +    
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430

Query: 946  EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
             EEA++D +       E+    R+    E      +     +  +R E  +     + EA
Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1490

Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
            +  Q      E  +L   A    E+ E ++   + EA R   R+++     D ++ +R+A
Sbjct: 1491 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1540

Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
            E    S  K ++E  RE+     AL       EE +L+AEE E    + EV    + +  
Sbjct: 1541 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1593

Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
                   AE E   + +  ++    L E SL+E  V + +     E+  +      ++  
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1646

Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
             ER   AR+   ++ E    + N AL+   +      + +LA  EAE   + +  E    
Sbjct: 1647 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1701

Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
              G+AEE A +  +     LE + +   G       Q+ +A E  ++  +   E  ++  
Sbjct: 1702 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1756

Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
            +  E++   L+ EA        + + E      + E +   +  A E       T+E + 
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1813

Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
            +  E  AG       E A  + +A +A     +AEE+   Q+       A A +V+ E+L
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1866

Query: 1409 ARSGE 1413
            A  GE
Sbjct: 1867 AAIGE 1871



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)

Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
            EE    AE  R ++R+ +   E++ A E+++      +  K  +ERE       +++E  
Sbjct: 1372 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429

Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
             +EE  + A++ +   +   ++  ++      S+AE +A    +E ++   L  E+ ++ 
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1483

Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
              + + EAT     G E  L+ + A  +E   ++     + E   R+             
Sbjct: 1484 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542

Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
            EL+SR   E  A +E  R            ++ E  L   E E A +VQ        + +
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602

Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
            AE     A   +  A LE   + +      LR +     +    AE+ REEA  E    +
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662

Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
                  L      +  ++     + E   QK E        A       G+  E A  +R
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1714

Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
            E LA  E  +++ +A   +     AE+E    + E   +     +++ EELAR   E  A
Sbjct: 1715 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1772

Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
            A +       E        +E   +   + +EE    SE  +    +  GR    A E  
Sbjct: 1773 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1831

Query: 1475 RL-GLSREGERE 1485
            RL  L+ E +R+
Sbjct: 1832 RLRALAEEAKRQ 1843



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)

Query: 800  EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
            E   VH   L   K  A   E A+   E+++    +E   +G    +AEAE V  L E  
Sbjct: 1027 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084

Query: 856  -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
             + P  ++  +  +G   ++     A+ L  L+T      G QG E+ + A+E       
Sbjct: 1085 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1143

Query: 908  AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            A    L  L    A+L++     E +     A+ D     +E    L+      D   +R
Sbjct: 1144 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1203

Query: 967  --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
              E  ++     +A+L   +  +   E +  + R        L  +  +A   + Q+   
Sbjct: 1204 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1263

Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
              ++       L +E  L +E     E V E +   +     I   EL L   + + E  
Sbjct: 1264 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1323

Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
             +  +K      ++S  +E         E      Q +K     +ET  R EEE +    
Sbjct: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1380

Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
            +   + E  A VEA+                            EK    +     +   +
Sbjct: 1381 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1412

Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
               EA++ + + +EE+  RE  A+     K   +++ +    + EAE   K +  E    
Sbjct: 1413 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1472

Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
            +  + EE   +       LE     +GG +  L+   A AEE      + +EEA  +   
Sbjct: 1473 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529

Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
             ++E  ++   E E      +E +   E +   Q           A+E L    E AE  
Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1578

Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
              +      R+V    ETA+   E  + +K +SF++   +     Q+E V    A  +  
Sbjct: 1579 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1636

Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
             E  A+   E   A E          +    AL      L  + EE ++ +  A    + 
Sbjct: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1691

Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
            ++E    E  R G + E    +REL+ + L+    L
Sbjct: 1692 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1727



 Score = 37.7 bits (86), Expect = 0.086
 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)

Query: 457  SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
            SA+   TG K+  +       +      +L+D     L+ +      +D E+      E 
Sbjct: 4033 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4092

Query: 513  SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
            + + G  D +MN I   P DD K   DP  E   +  +  +    + D   G     L+E
Sbjct: 4093 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4150

Query: 573  DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
             K++ KT+S +S R             + D E   + S  E+ R+             ++
Sbjct: 4151 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4194

Query: 633  HLPIEESLEIEIEDQEITKADVETKPMPID 662
            +L + E  E E E+  I+ +D   K M ID
Sbjct: 4195 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4223


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 203/982 (20%), Positives = 375/982 (38%), Gaps = 130/982 (13%)

Query: 403  LDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462
            L+ K      R E   E   EL   + K+  E   +    ++++     V  +  A E K
Sbjct: 917  LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 976

Query: 463  T-GLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
               L E +  ++E+ +K    ++ L++  +  L     +D +V+E+K    S  + + + 
Sbjct: 977  VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL-----DDLQVEEDKVNSLSKSKVKLEQ 1031

Query: 522  QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKD-ENDGCS-ESELEEDKQDMKT 579
            Q++ +  S   +KK  +D E+            ++++ D END    E +L++ + D+  
Sbjct: 1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDI-- 1089

Query: 580  ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEES 639
                    +  +S  EDE  +                      L    K +++   IEE 
Sbjct: 1090 --------NQQNSKIEDEQVLA---------------------LQLQKKLKENQARIEE- 1119

Query: 640  LEIEIEDQEITKADVETKPMPIDESFENVLKEGTEK-GTQEIAEGLSEKSGKHVSAEEKE 698
            LE E+E +   +A VE     +    E + +   E  G   +   +++K         ++
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1179

Query: 699  KDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKE 758
             +++ L  E+TA    KK      E G +          L      F + E   + SN E
Sbjct: 1180 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL-ELDDVTSNME 1238

Query: 759  SQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQ 818
              Q+++    LEK     ED+A ++R            L     ++++   +  K   E 
Sbjct: 1239 --QIIKAKANLEKVSRTLEDQANEYR----------VKLEEAQRSLNDFTTQRAKLQTEN 1286

Query: 819  PELAEEFTEKREIPPGIERGAEGAAE--AEGVRRLGEGGSDPIGQAAAK-------DAVG 869
             ELA +  EK  +   + RG     +   +  R+L E G      A A        D + 
Sbjct: 1287 GELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR 1346

Query: 870  LSKDEAPEKQALMLTVL--------------ETD------------KAASEGEQGLEKAV 903
               +E  E +A +  VL              ETD            K  ++  Q  E+AV
Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAV 1406

Query: 904  LANEAAALNLEHL-HEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDT 962
             A  A   +LE   H +    E    +   +    A  D  +   +  I  E     E++
Sbjct: 1407 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD-KILAEWKQKYEES 1465

Query: 963  ASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEA 1022
             S+ E   +EA     E  K +     +   L  F  E +  + ++S+ + + G   K  
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525

Query: 1023 F--------LCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTD 1074
                     L  E +E +  + EAEA+ E +  +IL  +L+  + + + ER    L + D
Sbjct: 1526 HELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER---KLAEKD 1582

Query: 1075 SEREEVTR-----ANALK---DEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126
             E E+  R      ++L+   D +     + L+ ++ + E ++   E   +  N M ++A
Sbjct: 1583 EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKK-KMEGDLNEMEIQLSHANRMAAEA 1641

Query: 1127 ENEAPVEASELSD-----NPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGER 1181
            + +     S L D     +  +   D LKE +  +       +  LE + A+ ++    R
Sbjct: 1642 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 1701

Query: 1182 -LSEARDTEHKDREELSSRENRAL-KEGHRQDGEGALAAPEAEPA------GKVQAPEGL 1233
             L+E    E  +R +L   +N +L  +  + + +      E E A       + +A + +
Sbjct: 1702 KLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAI 1761

Query: 1234 IPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDED 1293
              A   AEEL  K+ D+ A LE   +        L+ +   AE+  +   K + + ++  
Sbjct: 1762 TDAAMMAEEL-KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEAR 1820

Query: 1294 PEEEEDKECTLETEAMQDRNSE 1315
              E E      E EA Q RN+E
Sbjct: 1821 VRELEG-----ELEAEQKRNAE 1837



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 154/780 (19%), Positives = 287/780 (36%), Gaps = 104/780 (13%)

Query: 398  IIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFS 457
            ++A+ L KK    ++R E+  E+ E  + A  KV K R  +  +  EI E         S
Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1160

Query: 458  AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517
             Q            +E    +    Q++  D +E TL  ++E       +K  +   E G
Sbjct: 1161 VQ------------IEMNKKREAEFQKMRRDLEEATL--QHEATAAALRKKHADSVAELG 1206

Query: 518  QADVQMNGIPQSPLDDKKDNLDPEKESETSS-QKAPDARDNVKDEN----DGCSESELEE 572
            +    +  + Q  L+ +K     E +  TS+ ++   A+ N++  +    D  +E  ++ 
Sbjct: 1207 EQIDNLQRVKQK-LEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKL 1265

Query: 573  DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQE-----LSEND 627
            ++        T+ R+   + + E    + ++EA     T      +   E     L E  
Sbjct: 1266 EEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEG 1325

Query: 628  KPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEK 687
            K + +   +  +L+    D ++ +   E +     E     L+    K   E+A+  ++ 
Sbjct: 1326 KAKNA---LAHALQSARHDCDLLREQYEEETEAKAE-----LQRVLSKANSEVAQWRTKY 1377

Query: 688  SGKHVS-AEEKEKDKSKLW------EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGA 740
                +   EE E+ K KL       EE+   V  K + L   +   ++ +          
Sbjct: 1378 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE--------- 1428

Query: 741  PTMNFMVD------ETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGE 794
               + MVD        AA++  + +   +   +  + +E+  E E+ Q     +      
Sbjct: 1429 ---DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL-----S 1480

Query: 795  AALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEG 854
              L+    A  E+         E   L EE ++  E    +  G +   E E VR+  E 
Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE---QLGEGGKNVHELEKVRKQLEV 1537

Query: 855  GSDPIGQAAAKDAVGLSKDEAPEKQALM---LTVLETDKAASEGEQGLEKA------VLA 905
                +  A  +    L  +E    +A +       E ++  +E ++ +E+A      V+ 
Sbjct: 1538 EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVD 1597

Query: 906  NEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASID-------LEDTGP 958
            +   +L+ E       LR     E    E  + +S       EA          L+DT  
Sbjct: 1598 SLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI 1657

Query: 959  MEDTASKREDGSEEAILGGE--------EPAKERKEVMRTETRLSPFTGEAEASRMQVSE 1010
              D A +  D  +E I   E        E  + R  V +TE        E   +  +V  
Sbjct: 1658 QLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQL 1717

Query: 1011 GSPEEGSLAKEAFLCKEDV-----EGEEMVTEAEANREDDRKEILPKELDLARERRKA-- 1063
               +  SL  +    + D+     E EE V E   N E+  K+ +     +A E +K   
Sbjct: 1718 LHSQNTSLINQKKKMESDLTQLQSEVEEAVQECR-NAEEKAKKAITDAAMMAEELKKEQD 1776

Query: 1064 -----ERPKTSLRKTDSE-REEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
                 ER K ++ +T  + +  +  A  +  +   K+ QKL+A   E E E+ AE++  A
Sbjct: 1777 TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNA 1836


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 138/616 (22%), Positives = 234/616 (37%), Gaps = 74/616 (12%)

Query: 402  GLDKKPSLPKSRKEKSTEKGEELKKAEGK--VRKEREYVIPKRNEIKENKTSVSAKFSAQ 459
            GL K PS+    K KS EK + ++K+E +  + +E+        E+ E +   + +   +
Sbjct: 425  GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK 484

Query: 460  EIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA 519
            E + G +E     EE T K  P +E    ++E     + EE     E K  EK   +  A
Sbjct: 485  EEEGGEEEEAEGGEEET-KSPPAEEAASPEKEAKSPVK-EEAKSPAEAKSPEKEEAKSPA 542

Query: 520  DVQMNGIPQSPLDDKKDNLDPEKESETSSQKAP-------DARDNVKDENDGCSESELEE 572
            +V+     +SP  ++  +    K  E    K+P        A+   K+E    +E++  E
Sbjct: 543  EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE 602

Query: 573  DKQD--MKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDE--SARRSSSQELSENDK 628
              +    + A S +    P   +++  + V   E     + +E  S  ++ S E  E   
Sbjct: 603  KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS 662

Query: 629  PRKSHLPIEESLEIEIEDQEITKADV---ETKPMPIDESFENVLK---------EGTEKG 676
            P K+  P++   +   + +   KA+    E    P+ E  ++  K         +  EK 
Sbjct: 663  PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA 722

Query: 677  TQEIAEGLS--EKSGKHVSAEEKEKDKSKLWEES-TAQVKDKKAGLPGLEEGGK--DSLP 731
               + E     EK+   V  E K  +K+K  E++ T  VK  +A  P  EE     D  P
Sbjct: 723  KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP 782

Query: 732  LAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTL--EKKEAMEEDEAPQHRDADIV 789
                    +P    +     A +  KE  +  +K      E K  ++E+E PQ       
Sbjct: 783  ----EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP 838

Query: 790  QGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIP---------PGIERGAE 840
              K E           E    A   T E+ +  +E   K+E P         P +E+  E
Sbjct: 839  PKKAE-----------EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887

Query: 841  GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900
               EA+      +    P  +  A   V + +D  P+++  +      D  A E  +  E
Sbjct: 888  SKVEAK-KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946

Query: 901  KAVLANEAAALNLEHLHEVAALREAATSEEGEA-EGGVAVS------DVGESEEEASIDL 953
            K     EAA    +   E A   E     E +A E    +S         ++E+ +S D 
Sbjct: 947  K----KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002

Query: 954  EDTGP----MEDTASK 965
            +D+ P     ED A+K
Sbjct: 1003 KDSKPPEKATEDKAAK 1018



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 145/716 (20%), Positives = 271/716 (37%), Gaps = 118/716 (16%)

Query: 420  KGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKG 479
            +GEE +   G +       +PK   +  +   V ++   + ++   KE V  VEE T + 
Sbjct: 407  EGEECRIGFGPIPFSLPEGLPKIPSVSTH-IKVKSEEKIKVVEKSEKETVI-VEEQTEET 464

Query: 480  KPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLD 539
            +  +EV E++++   + E +E+ E  EE++ E   EE           +SP  ++  + +
Sbjct: 465  QVTEEVTEEEEKEAKEEEGKEE-EGGEEEEAEGGEEE----------TKSPPAEEAASPE 513

Query: 540  PEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESA 599
             E +S    +    A     ++ +  S +E++  ++  K+ +   ++S P +   E E A
Sbjct: 514  KEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK-AKSPAKEEAKSPPEAKSPEKEEA 572

Query: 600  VGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIED----QEITKADVE 655
                E  +       A+  +    +E   P K+  P++E  +   E     +E  K+  E
Sbjct: 573  KSPAEVKSPEKAKSPAKEEAKSP-AEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE 631

Query: 656  TK-PMPIDESFENVLKEGTEKGTQEIAEGLS-EKSGKHVSAEEKEKDKSKLWEESTAQVK 713
             K P       +   K   +  + E  E  S EK+   V AE K  +K+K   ++ A+  
Sbjct: 632  VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK-S 690

Query: 714  DKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKE 773
             +KA  P  EE               +P          A +  KE  +  +K  +  K+E
Sbjct: 691  PEKAKSPVKEEAKSPE-------KAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE 743

Query: 774  AMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPP 833
            A   ++A     A  +  K   A         + P    K  A  P  A++F EK + P 
Sbjct: 744  AKSPEKAKSPEKAKTLDVKSPEA---------KTPA---KEEARSP--ADKFPEKAKSP- 788

Query: 834  GIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAAS 893
             ++   +   +A               ++  K+     + E P+K+ +   V E +K   
Sbjct: 789  -VKEEVKSPEKA---------------KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP-- 830

Query: 894  EGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDL 953
                                    EV        +EE +A          ++EE+     
Sbjct: 831  -----------------------QEVKVKEPPKKAEEEKAPA------TPKTEEKKDSKK 861

Query: 954  EDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGS- 1012
            E+    E    K E+  E A+   +E   E K+    + +  P   +   ++++V E + 
Sbjct: 862  EEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK 921

Query: 1013 -PEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRK--AERPKTS 1069
              E+  +AK+     +D + +E    AE      +KE  P++ D   E+ K   E+PKT 
Sbjct: 922  PKEKTEVAKKE---PDDAKAKEPSKPAE------KKEAAPEKKDTKEEKAKKPEEKPKTE 972

Query: 1070 LRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSD 1125
             +  +             D+   KE  K KAE+ E  +    +++   PP +   D
Sbjct: 973  AKAKED------------DKTLSKEPSKPKAEKAEKSSS--TDQKDSKPPEKATED 1014



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 128/557 (22%), Positives = 206/557 (36%), Gaps = 69/557 (12%)

Query: 817  EQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP 876
            E+ ++ EE TE+ E     E G E   E  G     EGG +      A++A       +P
Sbjct: 462  EETQVTEEVTEEEEKEAKEEEGKE---EEGGEEEEAEGGEEETKSPPAEEAA------SP 512

Query: 877  EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHL-----HEVAALREAATSEEG 931
            EK+A    V E  K+ +E +   EK    + A   + E        E  +  EA + E+ 
Sbjct: 513  EKEAKS-PVKEEAKSPAEAKSP-EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKE 570

Query: 932  EAEGGVAVSDVGESE----EEASIDLEDTGPMEDTASKREDGSE--EAILGGEEPAKERK 985
            EA+    V    +++    EEA    E   P +  +  +E+     EA    +E AK   
Sbjct: 571  EAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA 630

Query: 986  EVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMV---TEAEANR 1042
            EV   E   SP   EA++     S    E  S  K     K + +  E      +AEA  
Sbjct: 631  EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKS 690

Query: 1043 EDDRKEILPKEL-----------DLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
             +  K  + +E            + A+   KA+ P     KT  + +   +  A   E A
Sbjct: 691  PEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA 750

Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDS-LK 1150
               E+    +    E +  A+EE ++P ++    A++    E          L ED+   
Sbjct: 751  KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAP 810

Query: 1151 ETVVPIFEATPGFEKSLENITALRKEGGGERLSE------ARDTEHKDREELSSRENRAL 1204
            E  +P  E      K  E    ++ +   ++  E       +  E KD ++  + +  A 
Sbjct: 811  EKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAP 870

Query: 1205 KEGHRQDGEGALAAP----------EAEPAGKVQAPEGLIPATGQAEELA-AKDHDSCAG 1253
            K    +  E A+  P          EAE   KV  PE   PA  + +E A  K+    A 
Sbjct: 871  KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAK 930

Query: 1254 LEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRN 1313
             E                +A A+E    AEK +E A ++   +EE  +   E    + + 
Sbjct: 931  KE--------------PDDAKAKEPSKPAEK-KEAAPEKKDTKEEKAKKPEEKPKTEAKA 975

Query: 1314 SEGDGDMEGEGNTQKNE 1330
             E D  +  E +  K E
Sbjct: 976  KEDDKTLSKEPSKPKAE 992



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 110/588 (18%), Positives = 230/588 (39%), Gaps = 67/588 (11%)

Query: 570  LEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKP 629
            +EE  ++ +     +      + + E +   G  E   +   +E+ +   ++E +  +K 
Sbjct: 457  VEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEET-KSPPAEEAASPEKE 515

Query: 630  RKSHLPIEESLEIEIE----DQEITKADVETK-PMPIDESFENVLKEGTEKGTQEIAEGL 684
             KS  P++E  +   E    ++E  K+  E K P       +   K   E  + E  E  
Sbjct: 516  AKS--PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEA- 572

Query: 685  SEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMN 744
              KS   V + EK K  +K   +S A+ K  +     ++E  K        +   A +  
Sbjct: 573  --KSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA 630

Query: 745  FMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQG-KGEAALWGEAGA 803
             +     A +  KE  +  +K  + EK+EA   ++A     A+     K ++ +  EA  
Sbjct: 631  EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA-- 688

Query: 804  VHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAA 863
              ++P +A  P  E+ +  E+              A+   + E   +  E    P+ + A
Sbjct: 689  --KSPEKAKSPVKEEAKSPEK--------------AKSPVKEEA--KSPEKAKSPVKEEA 730

Query: 864  AKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALR 923
                      + PEK               E  +  EKA    +A  L+++        +
Sbjct: 731  ----------KTPEK---------AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAK 771

Query: 924  EAATS--EEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEP- 980
            E A S  ++   +    V +  +S E+A   L++     +    +++  +  +   E+P 
Sbjct: 772  EEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ 831

Query: 981  -AKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAE 1039
              K ++   + E   +P T + E  +    E +P++ +   +    KE    +   ++ E
Sbjct: 832  EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVE 891

Query: 1040 ANRED--DRKEI------LPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
            A +E+  D+K++       P ++++  + +  E+ + + ++ D  + +     A K E A
Sbjct: 892  AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA 951

Query: 1092 FKE----EQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEAS 1135
             ++    E+K K  E + +TE +A+E+ K    E       +A   +S
Sbjct: 952  PEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS 999



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 154/712 (21%), Positives = 272/712 (38%), Gaps = 103/712 (14%)

Query: 833  PGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAA 892
            P   RGA  A+  + +  L  G   P G   A   V  S+ E  + QAL       D+ A
Sbjct: 62   PSRFRGAGAASSTDSLDTLSNG---PEGCMVA---VATSRSEKEQLQAL------NDRFA 109

Query: 893  S--EGEQGLE--KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEE 948
               +  + LE     L  EAAAL  +     +A+ E    E  E  G  AV  +G +  +
Sbjct: 110  GYIDKVRQLEAHNRSLEGEAAALRQQQAGR-SAMGELYEREVREMRG--AVLRLGAARGQ 166

Query: 949  ASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQV 1008
              ++ E    +ED A  R+   +EA        ++R+E       L+ F  EAEA+R+ +
Sbjct: 167  LRLEQEHL--LEDIAHVRQRLDDEA--------RQREEAEAAARALARFAQEAEAARVDL 216

Query: 1009 SEGSPEEGSLAKEAFLCKEDVEGE--EMVTE------AEANREDDRKEILPKELDLARER 1060
             + +    +L +E    +   + E  E++ +      A+A  + + ++ L  ++  A   
Sbjct: 217  QKKAQ---ALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALRE 273

Query: 1061 RKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
             +A+    +++ T  + EE  R    +  +A K          E  TE R + + +    
Sbjct: 274  IRAQLEGHAVQST-LQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL 332

Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
            E     ++    + SEL        ED  +  +    EA    +  L N     K     
Sbjct: 333  EALKSTKDSLERQRSEL--------EDRHQADIASYQEAIQQLDAELRNT----KWEMAA 380

Query: 1181 RLSEARDTEH-KDREELSSRENRALKEGHR-QDGEGALAAPEAEPAGKVQAPEGLIPATG 1238
            +L E +D  + K   ++     R L EG   + G G +             PEGL     
Sbjct: 381  QLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIP---------FSLPEGLPKIPS 431

Query: 1239 QAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEE 1298
             +  +  K  +                  ++  E   +E  I+ E+  E  V E+  EEE
Sbjct: 432  VSTHIKVKSEEK-----------------IKVVEKSEKETVIVEEQTEETQVTEEVTEEE 474

Query: 1299 DKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEERE 1358
            +KE   E    + +  EG  + E EG  ++ +        + E      E      EE +
Sbjct: 475  EKEAKEE----EGKEEEGGEEEEAEGGEEETKSPPAEEAASPE-----KEAKSPVKEEAK 525

Query: 1359 VLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAA 1418
              A +++ E++    +A S ++V   E      +   K+    K   +E A+S  EV + 
Sbjct: 526  SPAEAKSPEKE----EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSP 581

Query: 1419 EEMTVTYTTEA-GVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLG 1477
            E+       EA       + E+  S + +E +  +E +           E  + EK +  
Sbjct: 582  EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641

Query: 1478 LSREG---ERELSPESLQA----MATLPVKPDFTETREKQQHMVQGESETAD 1522
               E    E+  SPE  +A     A  PVK +  ++ EK +  V+ E+++ +
Sbjct: 642  TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE-AKSPEKAKSPVKAEAKSPE 692



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 48/207 (23%), Positives = 87/207 (42%), Gaps = 15/207 (7%)

Query: 409  LPKSRKEKSTEKGEE------LKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462
            +PK  + KS  K EE      +K+   K  +E+    PK  E K++K   + K  A + K
Sbjct: 814  IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873

Query: 463  TGLKEVVTAVEEMTSKGKPGQEVLED-------DQENTLKYEYEEDFEVDEEKQGEKSNE 515
               K+     +   SK +  +E  ED       ++E   K E +ED +  E+ +  K  E
Sbjct: 874  VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAK-KE 932

Query: 516  EGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQ 575
               A  +    P    +   +  D ++E     ++ P      K+++   S+   +   +
Sbjct: 933  PDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAE 992

Query: 576  DMKTASSTSSR-SHPYSSDSEDESAVG 601
              + +SST  + S P    +ED++A G
Sbjct: 993  KAEKSSSTDQKDSKPPEKATEDKAAKG 1019



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 106/478 (22%), Positives = 178/478 (37%), Gaps = 55/478 (11%)

Query: 769  LEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEK 828
            LE++  +E+    + R  D  + + EA          EA  RA    A++ E A    +K
Sbjct: 169  LEQEHLLEDIAHVRQRLDDEARQREEA----------EAAARALARFAQEAEAARVDLQK 218

Query: 829  REIPPGIERGAEGAAEAEGVRRL-----GEGGSDPIGQAAAKDAVGLSKDEAPEKQALML 883
            +      E G       E V  L     G G +    QA  +DA+      A        
Sbjct: 219  KAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSA-------- 270

Query: 884  TVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALR-EAATSEEGEAEGGVAVSDV 942
              L   +A  EG   ++  + + E   + L+ L E A +  +A  S + E          
Sbjct: 271  --LREIRAQLEGH-AVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQA 327

Query: 943  GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
              +E EA    +D+  +E   S+ ED  +  I      A  ++ + + +  L     E  
Sbjct: 328  RTTELEALKSTKDS--LERQRSELEDRHQADI------ASYQEAIQQLDAELRNTKWEMA 379

Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----------VTEAEANREDDRKEILPK 1052
            A   +  +    + +L  E    ++ +EGEE           + E           I  K
Sbjct: 380  AQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVK 439

Query: 1053 ELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE 1112
              +  +   K+E+ +T + +  +E  +VT     ++E   KEE+  + E GE E     E
Sbjct: 440  SEEKIKVVEKSEK-ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498

Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
            EETK+PP E  +  E EA     E + +P        +E        +P   KS E   +
Sbjct: 499  EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA------KSPAEVKSPEKAKS 552

Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAP 1230
              KE   E  S       +  E  S  E ++ ++      E A +  EA+   K ++P
Sbjct: 553  PAKE---EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP 607



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 70/320 (21%), Positives = 128/320 (40%), Gaps = 44/320 (13%)

Query: 405  KKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG 464
            +K   P   + KS EK +  +KA+    K  E   P + E +    S + KF  ++ K+ 
Sbjct: 734  EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR----SPADKFP-EKAKSP 788

Query: 465  LKEVVTAVEEMTSKGK-----PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA 519
            +KE V + E+  S  K     P +E+ + ++  +   E E+  EV  ++  +K+ EE   
Sbjct: 789  VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE--- 845

Query: 520  DVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDEN--DGCSESELE---EDK 574
                    ++P   K +     K+ E   ++AP  +   K E   +   ES++E   E+ 
Sbjct: 846  --------KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897

Query: 575  QDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHL 634
            +D K   +    +       ED       E       D  A+  S     +   P K   
Sbjct: 898  EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDT 957

Query: 635  PIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSA 694
              E++ + E + +   KA                 KE  +  ++E ++  +EK+ K  S 
Sbjct: 958  KEEKAKKPEEKPKTEAKA-----------------KEDDKTLSKEPSKPKAEKAEKSSST 1000

Query: 695  EEKE-KDKSKLWEESTAQVK 713
            ++K+ K   K  E+  A+ K
Sbjct: 1001 DQKDSKPPEKATEDKAAKGK 1020


>gi|87299628 biorientation of chromosomes in cell division 1-like
            [Homo sapiens]
          Length = 3051

 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 164/823 (19%), Positives = 318/823 (38%), Gaps = 141/823 (17%)

Query: 413  RKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAV 472
            +K KST+KGE  KK +   + ER+         KE K     KF   +     ++V    
Sbjct: 314  QKNKSTDKGE--KKPDSNEKGERK---------KEKKEKTEKKFDHSKKSEDTQKV---K 359

Query: 473  EEMTSKGKPGQEVLEDDQENTLKYE----YEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ 528
            +E  +K K  + +    ++N+ K +     +EDF + +      S+ +G  D+ ++ +  
Sbjct: 360  DEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLID------SDVDGLTDITVSSVHT 413

Query: 529  SPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSH 588
            S L   ++  D E+E  TS               D   E E+  D ++    + T ++  
Sbjct: 414  SDLSSFEE--DTEEEVVTS---------------DSMEEGEITSDDEEKNKQNKTKTQ-- 454

Query: 589  PYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQE 648
              +SDS +      R A+       S   S S +    ++ R+S   I +  E  +  ++
Sbjct: 455  --TSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQS---IAKEKEERLLRRQ 509

Query: 649  ITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKS-KLWEE 707
            I +  +E K     E  ++   +G  + + ++ E  S KS +  +A  KE  K  K+ E+
Sbjct: 510  INREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEES-STKSLEPKAARIKEVLKERKVLEK 568

Query: 708  STAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTY 767
              A  K +K     +EE                             NS K+ Q       
Sbjct: 569  KVALSKKRKKDSRNVEE-----------------------------NSKKKQQYEEDSKE 599

Query: 768  TLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTE 827
            TL+  E  E+++    ++   V  K E +    A  + E+ L        + +L  E  +
Sbjct: 600  TLKTSEHCEKEKISSSKELKHVHAKSEPS--KPARRLSES-LHVVDENKNESKLEREH-K 655

Query: 828  KREIPPGIERGAEGAAEAEGVRRLGEGG----SDPIGQ-AAAKDAVGLSKD--EAPEKQA 880
            +R   P I  G +   +   V+R  E       +P  Q +  K+   L KD  E P  ++
Sbjct: 656  RRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKS 715

Query: 881  LMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEE-GEAEGGVAV 939
            L+   +++ K   E E+             L+++H ++   + +     E   +E G+ V
Sbjct: 716  LLKKEVKSSKEKPEREK-------TPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKV 768

Query: 940  SD-VGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGE-EPAKE---------RKEVM 988
             + + +  ++  +  +D     +  SK  +  + ++LG + +P  E         RKE  
Sbjct: 769  EENIQKQSQQTKLSSDD---KTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENN 825

Query: 989  RTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKE 1048
            + E RLS    +AE    + S+   ++ SL  +         G  +   +E+  ED    
Sbjct: 826  KKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQ-------HGITLQRRSESYSED---- 874

Query: 1049 ILPKELDLARERRKAE-RPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETET 1107
                + D+      +  +P+  + K     + +     +    +  + +++K  E E + 
Sbjct: 875  ----KCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQE 930

Query: 1108 EVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKET-VVPIFEATPGFEKS 1166
                +  T  P  E  ++  +      S++ D P        +ET V P+ E       S
Sbjct: 931  GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKP-------FEETGVEPVLETASSSAHS 983

Query: 1167 LENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHR 1209
             +  ++ R      +L  A++    D++  S+R  R L +GH+
Sbjct: 984  TQKDSSHR-----AKLPLAKEKYKSDKDSTSTRLERKLSDGHK 1021



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 232/1158 (20%), Positives = 413/1158 (35%), Gaps = 195/1158 (16%)

Query: 403  LDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKF-SAQEI 461
            L+KK +L K RK+ S       +  E   +K+++Y    +  +K ++     K  S++E+
Sbjct: 566  LEKKVALSKKRKKDS-------RNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKEL 618

Query: 462  KTGLKEVVTAVEEMTSKGKPGQEVLE-----DDQENTLKYEYEEDFE-----VDEEKQGE 511
            K         V   +   KP + + E     D+ +N  K E E         + E  Q E
Sbjct: 619  K--------HVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEE 670

Query: 512  KSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELE 571
                + +  V+ + I       +K  L  EK  +    + P  +  +K E     +S  E
Sbjct: 671  TDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKE----VKSSKE 726

Query: 572  EDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDS---STDESARRSSSQ-ELSEND 627
            + +++   +    S  H Y  D   ++   + E H+       +E+ ++ S Q +LS +D
Sbjct: 727  KPEREKTPSEDKLSVKHKYKGDCMHKTG-DETELHSSEKGLKVEENIQKQSQQTKLSSDD 785

Query: 628  K-PRKSHLPIEESLEIEIEDQEITKADVETKPMP--IDESFENVLKEGTEKGTQEIAEGL 684
            K  RKS    E  L +  +D          KP+   I ++ ENV KE  +K  +  AE  
Sbjct: 786  KTERKSKHRNERKLSVLGKD---------GKPVSEYIIKTDENVRKENNKKERRLSAE-- 834

Query: 685  SEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSL-PLAYVLALGAPTM 743
                      + K + KS+   +S  Q               KDSL    + + L   + 
Sbjct: 835  ----------KTKAEHKSRRSSDSKIQ---------------KDSLGSKQHGITLQRRSE 869

Query: 744  NFMVD----ETAAINSNKESQQLVQK-----TYTLEKKEAMEEDEAPQHRDADIVQGKGE 794
            ++  D    ++  ++SN + +++V K        LE+K  ++     Q +   +V     
Sbjct: 870  SYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVV----- 924

Query: 795  AALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEG 854
                 E      A  +A  P  ++ +  EE   +++    +E            +   E 
Sbjct: 925  -----ETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVED-----------KPFEET 968

Query: 855  GSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLE 914
            G +P+ + A+  A    KD +   +A +    E  K+  +      +  L++   + +L+
Sbjct: 969  GVEPVLETASSSAHSTQKDSS--HRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLK 1026

Query: 915  HLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAI 974
            H  +    ++   S++ + +      +V  S E+A     ++  ME   S+R   +    
Sbjct: 1027 HSSKDIKKKDENKSDDKDGK------EVDSSHEKAR---GNSSLMEKKLSRRLCENRRGS 1077

Query: 975  LGGEEPAKERKEVMRTETRLS--------------------PFTGEAEASRMQVSEGSPE 1014
            L  E    E K    T +  S                    P   ++E     V E S  
Sbjct: 1078 LSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKT 1137

Query: 1015 EGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAER---PKTSLR 1071
            + +    +   ++D++ E M  +  A  + D       +        K  R     ++  
Sbjct: 1138 QDNRNNNS---QQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSE 1194

Query: 1072 KTDSEREEVTRANALKDE-DAFKEEQKLKAEEGETETEVRAE-----------EETKAPP 1119
            K    R  +T+   ++         +K     G TE  + +E           E  +   
Sbjct: 1195 KHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQK 1254

Query: 1120 NEMGSDAENEAPVEASELSDNPGLLGEDSLKE-TVVPIFEA-TPGFEKSLENITALRKEG 1177
            N   + AE       + L  +  L    SL   TVVP+ E+  P      +  T L  EG
Sbjct: 1255 NLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVL--EG 1312

Query: 1178 GGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPAT 1237
                 S A D      + L+ RE+  LK    ++G          PA      +  IP  
Sbjct: 1313 STASTSPA-DHSALPNQSLTVRESEVLKTSDSKEGGEGFTVD--TPAKASITSKRHIPEA 1369

Query: 1238 GQAEELAAKDHDSCAGLEGRAEG----------QGG-VDVVLRTQEAVAEED-----PIM 1281
             QA  L  K       L  +  G          +GG VD+  +  +  AE +        
Sbjct: 1370 HQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKAT 1429

Query: 1282 AEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEG---DGDMEGEGNTQKNE-GMGGGRV 1337
             E  +++ +  D     + E   ET  ++ + S G   D  ++ E   + +E     G  
Sbjct: 1430 VENGKKDGIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSG 1489

Query: 1338 VAVEVLH-GGGETAETAA----EEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDE 1392
             A  VLH   G+T + A      E+  +A S   ++K +              +  +Q E
Sbjct: 1490 SAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSE 1549

Query: 1393 L----VGKTAAAGKVVVEELARSGEEVPA-AEEMTVTYTTEAG--VGTPGALERKTSGLG 1445
            +        A  G ++      +   V A A E TV    E G  V T G  E +T    
Sbjct: 1550 VALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESET--FL 1607

Query: 1446 QEQEEGSEGQEAATGSGD 1463
               +EG  G+ A   S D
Sbjct: 1608 TSTKEGESGECAVAESED 1625



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 207/1084 (19%), Positives = 371/1084 (34%), Gaps = 145/1084 (13%)

Query: 402  GLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKE--REYVIPKRNEIKENKTSVSAKFSAQ 459
            G  K+ + PK  KEK+TE+ +  K+ + KV  +   E  +    E   +    + K S+ 
Sbjct: 931  GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSH 990

Query: 460  EIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA 519
              K  L +     ++ ++  +  +++ +  +  +LK+  ++  + DE K  +K  +E  +
Sbjct: 991  RAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDS 1050

Query: 520  DVQMNGIPQSPLDDK-KDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMK 578
              +      S ++ K    L   +    S + A        +     S S L+  K+   
Sbjct: 1051 SHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKK--- 1107

Query: 579  TASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQEL-SENDKPRKSHLPIE 637
               S      P     E +S  G       S T ++   +S Q++ SEN K + S    +
Sbjct: 1108 ---SGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQK 1164

Query: 638  ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697
            + L     D + T                   K G  +GT     G++  S KH  A+ +
Sbjct: 1165 DELRTCTADSKATAP---------------AYKPG--RGT-----GVNSNSEKH--ADHR 1200

Query: 698  EKDKSKLWEESTAQVKDKKAGLP---GLEEGGKDSLPLAYVLALGAPTMNFMV------- 747
                 K+  +S     +     P   G  E   DS    + + L AP+ N  V       
Sbjct: 1201 STLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDS-ETVHRMLLSAPSENDRVQKNLKNT 1259

Query: 748  ---------DETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGK------ 792
                     D T   ++N +S   +     +  +E+ + D  P      +++G       
Sbjct: 1260 AAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSP 1319

Query: 793  -GEAALWGEAGAVHEAPLRAWKPTAEQPE-------LAEEFTEKREIPPGIERGAEGAAE 844
               +AL  ++  V E+ +     + E  E            T KR IP   +       +
Sbjct: 1320 ADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQ 1379

Query: 845  AEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVL 904
             + +  LG   +  I +       G   D A ++  L           +  E G +  + 
Sbjct: 1380 GKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVENGKKDGIA 1439

Query: 905  ANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTAS 964
             +    LN E   E   L+   +  + +    +++ DV    E + +D         +  
Sbjct: 1440 VDHVVGLNTEKYAETVKLKHKRSPGKVK---DISI-DVERRNENSEVDTSAGSGSAPSVL 1495

Query: 965  KREDGSEEAILGGEEPAKERKEVMRTETRLSPFT-GEAEASRMQVSEGSPEEGSLAKEAF 1023
             + +G  E +  G   A++      TE +    T    +A     +     +  +A    
Sbjct: 1496 HQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALPCT 1555

Query: 1024 LCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRA 1083
              + D EG  + T +  N            L +  E  +     T     +     VT  
Sbjct: 1556 SIEAD-EGLIIGTHSRNN-----------PLHVGAEASEC----TVFAAAEEGGAVVTEG 1599

Query: 1084 NALKDEDAFKEEQKLKAEEGE---TETEVRAEE-------ETKAPPNEMGSDAENEAPVE 1133
             A  + + F    K + E GE    E+E RA +       + +A  N + ++ +++A   
Sbjct: 1600 FA--ESETFLTSTK-EGESGECAVAESEDRAADLLAVHAVKIEANVNSVVTEEKDDAVTS 1656

Query: 1134 ASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDR 1193
            A       G L  DS       I E T  F   +E+  A+   G   R            
Sbjct: 1657 AGSEEKCDGSLSRDS------EIVEGTITFISEVESDGAVTSAGTEIRAGSI------SS 1704

Query: 1194 EELSSRENRALKEGHRQDGEGALAAPEAE----------PAGKVQAPEGLIPATGQAEEL 1243
            EE+   +   ++ G +++ EG +    AE            G     E ++   G    +
Sbjct: 1705 EEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAG----V 1760

Query: 1244 AAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECT 1303
               D+D+  G     EG G V+      +    E  + +    E+   E P      E +
Sbjct: 1761 VLGDNDAPPGTSASQEGDGSVN------DGTEGESAVTSTGITEDG--EGPASCTGSEDS 1812

Query: 1304 LETEAMQDRNSE-GDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAG 1362
             E  A+   + E G+  M+   +T   EG     V A      G  T+  A EE E   G
Sbjct: 1813 SEGFAISSESEENGESAMD---STVAKEGTNVPLVAAGPCDDEGIVTSTGAKEEDE--EG 1867

Query: 1363 SETAEEKTIANK---ASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAE 1419
             +        N+   AS+ + + EE       E     +  G VV    A +G  +  A 
Sbjct: 1868 EDVVTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNAN 1927

Query: 1420 EMTV 1423
            E  V
Sbjct: 1928 ENNV 1931



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 120/641 (18%), Positives = 235/641 (36%), Gaps = 103/641 (16%)

Query: 844  EAEGVRRLGEGGSDPIGQAAAKDAVGL-SKDEAPEKQALMLTVLETDKA-ASEGEQGLEK 901
            EA   R   E  +    + A+K      + D + +K+     + + +K+ A  G +GLE 
Sbjct: 214  EASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLET 273

Query: 902  AVLANEAAAL--------NLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDL 953
            A  + E + L        N    H    L      +E   +   + +D GE + +++   
Sbjct: 274  APKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKS-TDKGEKKPDSNEKG 332

Query: 954  EDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSP 1013
            E     ++   K+ D S+++     +  K+ K+    E        E  +++ +  EG+ 
Sbjct: 333  ERKKEKKEKTEKKFDHSKKS--EDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTK 390

Query: 1014 EEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT 1073
            E+ SL         DV+G   +T +  +  D                        S  + 
Sbjct: 391  EDFSLIDS------DVDGLTDITVSSVHTSD-----------------------LSSFEE 421

Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPP----------NEMG 1123
            D+E E VT  +  + E    +E+K K  + +T+T   +E +TK+            ++  
Sbjct: 422  DTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYY 481

Query: 1124 SDAENEAPVE------ASELSDN--PGLLGEDSLKETVVPIFEATPGFE----------- 1164
            SD+++E  VE      A E  +      +  + L+E      E T   +           
Sbjct: 482  SDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDL 541

Query: 1165 -----KSLENITALRKEGGGERLSEARDTEHKDREELSSR---ENRALKEGHRQDGEGAL 1216
                 KSLE   A  KE   ER    +      + +  SR   EN   K+ + +D +  L
Sbjct: 542  EESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETL 601

Query: 1217 AAPEAEPAGKVQAPEGL----------IPATGQAEELAAKDHD-SCAGLEGRAEGQGGVD 1265
               E     K+ + + L           PA   +E L   D + + + LE   + +    
Sbjct: 602  KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTP 661

Query: 1266 VVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE-----------EDKECTLETEAMQDRNS 1314
            V++   +   +   +  +  R E   E+P+++           +D   T   +++  +  
Sbjct: 662  VIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEV 721

Query: 1315 EGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANK 1374
            +   +      T   + +        + +H  G+  E  + E+  L   E  ++++   K
Sbjct: 722  KSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKG-LKVEENIQKQSQQTK 780

Query: 1375 ASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEV 1415
             SS  D  E ++ H+ +  +      GK V E + ++ E V
Sbjct: 781  LSS-DDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENV 820



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 120/592 (20%), Positives = 221/592 (37%), Gaps = 82/592 (13%)

Query: 950  SIDLEDTGPMEDTASKREDGSEEAILGGE----EPAKER-KEVMRTETRLSP-----FTG 999
            S+  ED  P   TA      S  A  G E     PA  R  E    +T   P     +  
Sbjct: 2468 SLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLA 2527

Query: 1000 EAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEE--------MVTEAEANREDDRKEILP 1051
                  ++  +  P +G++A+ +FL  E    E+         +T  E+        I P
Sbjct: 2528 AVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTKCITGQESKIAPSHTMIPP 2587

Query: 1052 KELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
                +A    K E+  T   K D   +   +A+A K  D     +K   EEG+    V +
Sbjct: 2588 ATYSVALLAPKCEQDLTI--KNDYSGKWTDQASAEKTGDD-NSTRKSFPEEGDIMVTVSS 2644

Query: 1112 EEET------KAPPNEMG-----SDAENEAPVEASELSDNPGLLGEDSL---KETVVPIF 1157
            EE        ++P N +G     ++ + EA V + E  +   L   +SL   K + +   
Sbjct: 2645 EENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAEL 2704

Query: 1158 EATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSS--RENRALKEGHRQDGEGA 1215
            +  P       N+     E  G R +E   +E  ++ E+SS  ++N     GH       
Sbjct: 2705 QREPLLVNESLNV-----ENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGH------- 2752

Query: 1216 LAAPEAEPAGKVQAPEGLIPATGQAEE-LAAKDH--DSCAGLEGRAEGQGGVDVVLRTQE 1272
              + EA+P  +V+  E  +P   + +  L+++D   D+   L+ R E           Q 
Sbjct: 2753 --SVEADPK-EVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIE---------TAQR 2800

Query: 1273 AVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNE-- 1330
               E +P   ++     ++E P+   +   T  +  M++++     +  GE   Q ++  
Sbjct: 2801 QCPETEPHDTKEENSRDLEELPKTSSETNSTT-SRVMEEKDEYSSSETTGEKPEQNDDDT 2859

Query: 1331 --GMGGGRVVAVEVLHGGG-----ETAETAAEEREVLAGSETAEEKTIANKASSF-SDVA 1382
                   + + ++   G       ET     ++ +   G  T E+   ++K     +D +
Sbjct: 2860 IKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDES 2919

Query: 1383 EEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA------AEEMTVTYTTEAGVGTPGA 1436
             +ET + Q+  +       K+V     R  +   +      AE        +  V  P  
Sbjct: 2920 NKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDP-V 2978

Query: 1437 LERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSP 1488
             ++K     +E+EE  E + +   +    +      K +L  S + +RE+SP
Sbjct: 2979 EDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSP 3030



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 204/1021 (19%), Positives = 362/1021 (35%), Gaps = 163/1021 (15%)

Query: 435  REYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTL 494
            RE  + K ++ KE     +    A+   T  + +  A +     GK G+ ++    + T 
Sbjct: 1333 RESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTG 1392

Query: 495  KYEYEEDFE-----VDEEKQGEKSNEEG------QADVQMNGIPQSPLDDKKDNLDPEKE 543
                 E+       VD  K+    N E       +A V+ NG       D    L+ EK 
Sbjct: 1393 VIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVE-NGKKDGIAVDHVVGLNTEKY 1451

Query: 544  SETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDR 603
            +ET   K   +   VKD +          +      + S  S  H  +  +ED  A G R
Sbjct: 1452 AETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDV-ATGPR 1510

Query: 604  EAHTDSSTDESARRSSSQELSE---------NDKPRKSHLPIEESLEIEIEDQEITKADV 654
             A   S    +  +     LS          + + R+S + +     IE ++  I     
Sbjct: 1511 RAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALP-CTSIEADEGLIIGTHS 1569

Query: 655  ETKPMPID-ESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVK 713
               P+ +  E+ E  +    E+G   + EG +E      S +E E       E + A+ +
Sbjct: 1570 RNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESETFLTSTKEGESG-----ECAVAESE 1624

Query: 714  DKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKE 773
            D+ A L                LA+ A            I +N  S    +K   +    
Sbjct: 1625 DRAADL----------------LAVHA----------VKIEANVNSVVTEEKDDAVTSAG 1658

Query: 774  AMEEDEAPQHRDADIVQGKGEAALWGEA-GAVHEA--PLRAWKPTAEQPELAE----EFT 826
            + E+ +    RD++IV+G        E+ GAV  A   +RA   ++E+ + ++       
Sbjct: 1659 SEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSISSEEVDGSQGNMMRMG 1718

Query: 827  EKREIPPGIE-RGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
             K+E    +   GAEG ++   +  +   G            V    D  P   A     
Sbjct: 1719 PKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVLGDNDAPPGTSASQ--- 1775

Query: 886  LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEA------EGGVAV 939
             E D + ++G +G E AV +        E     A+   +  S EG A      E G + 
Sbjct: 1776 -EGDGSVNDGTEG-ESAVTSTGIT----EDGEGPASCTGSEDSSEGFAISSESEENGESA 1829

Query: 940  SDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKER---KEVMRTETRLSP 996
             D   ++E  ++ L   GP +D       G++E    GE+         E+    T    
Sbjct: 1830 MDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEEDEEGEDVVTSTGRGNEIGHAST---- 1885

Query: 997  FTGEAEASR----MQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRK--EIL 1050
             TG  E S      + +EG  + G++ +       + E    +  A  N  D     E  
Sbjct: 1886 CTGLGEESEGVLICESAEGDSQIGTVVEHV-----EAEAGAAIMNANENNVDSMSGTEKG 1940

Query: 1051 PKELDLARERRKAERPKTSLRKTDSEREEVT---------RANALKDEDAFKEEQKLKAE 1101
             K+ D+    +     ++S+    S ++EVT           +A  D+    + Q  K E
Sbjct: 1941 SKDTDICSSAKGI--VESSVTSAVSGKDEVTPVPGGCEGPMTSAASDQ---SDSQLEKVE 1995

Query: 1102 E-----------------GET-ETEVRAEEETKAPPNEMGSDAENE------APVEASEL 1137
            +                 GE  E EV     ++    ++ +  ENE      A   + ++
Sbjct: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055

Query: 1138 SDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEA-RDTEHKDREEL 1196
            ++   L G  +  + ++     T  +   +  IT +  EGG   LS+A R  E+ +   +
Sbjct: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDV--EGG---LSDALRTEENMEGTRV 2110

Query: 1197 SSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEEL--------AAKDH 1248
            ++ E  A         +  L A  +E     +  E  + +T   EE           K  
Sbjct: 2111 TTEEFEAPMPSAVSGDDSQLTASRSE-----EKDECAMISTSIGEEFELPISSATTIKCA 2165

Query: 1249 DSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEA 1308
            +S   +    E +    V++ T +    E P+ +     E+      +EE  EC L + +
Sbjct: 2166 ESLQPVAAAVEERATGPVLISTADF---EGPMPSAPPEAESPLASTSKEEKDECALISTS 2222

Query: 1309 MQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEE 1368
            + +   E +  + G     +NE  G      +E   G G  + ++ E+ E    S   +E
Sbjct: 2223 IAE---ECEASVSGVVVESENERAG----TVMEEKDGSGIISTSSVEDCEGPVSSAVPQE 2275

Query: 1369 K 1369
            +
Sbjct: 2276 E 2276



 Score = 36.6 bits (83), Expect = 0.19
 Identities = 40/188 (21%), Positives = 82/188 (43%), Gaps = 15/188 (7%)

Query: 412  SRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTA 471
            S  E + EK E+      K ++E + +I KR   +  K  V      ++       +VT 
Sbjct: 2843 SSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVT- 2901

Query: 472  VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
            VE+  S  K   +V++ D+ N          E    ++   SN++G+  + +  + +   
Sbjct: 2902 VEQSPSSSK--LKVMQTDESNK---------ETANLQERSISNDDGEEKI-VTSVRRRGR 2949

Query: 532  DDKKDNL--DPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHP 589
              K+     D  + SE   ++     D V+D+ +  S+ E EE+++D  + ++T S +  
Sbjct: 2950 KPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRS 3009

Query: 590  YSSDSEDE 597
             +  S+ +
Sbjct: 3010 EAQRSKTQ 3017



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 48/229 (20%), Positives = 92/229 (40%), Gaps = 8/229 (3%)

Query: 410  PKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVV 469
            P   KE+++   EEL K   +       V+ +++E   ++T+        +     +E  
Sbjct: 2807 PHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEED 2866

Query: 470  TAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
              +     +G+P +  +E   +  +K + + D  +   +Q   S++        +    +
Sbjct: 2867 QPIIIKRKRGRPRKYPVETTLK--MKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETA 2924

Query: 530  PLDDKK-DNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSH 588
             L ++   N D E++  TS ++           +D    SE E  +Q  K+ S       
Sbjct: 2925 NLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ--KSVSDPVEDKK 2982

Query: 589  PYSSDSEDESAVGDRE--AHTDSSTDESARRSSSQELSENDKPRKSHLP 635
               SD E+E    D    A T S+T   A+RS +Q LS + K ++   P
Sbjct: 2983 EQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQ-LSPSIKRKREVSP 3030



 Score = 33.1 bits (74), Expect = 2.1
 Identities = 44/214 (20%), Positives = 88/214 (41%), Gaps = 23/214 (10%)

Query: 907  EAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            E  + +LE L + ++   + TS   E +   + S+    + E + D        DT   +
Sbjct: 2812 EENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDD--------DTIKSQ 2863

Query: 967  EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCK 1026
            E+  ++ I+   +  + RK  + T  ++       + S+      + E+   + +  + +
Sbjct: 2864 EE--DQPIIIKRKRGRPRKYPVETTLKMK------DDSKTDTGIVTVEQSPSSSKLKVMQ 2915

Query: 1027 EDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTD---SEREEVTRA 1083
             D   +E     E +  +D  E    E  +   RR+  +PK SL  +D   S   E  R 
Sbjct: 2916 TDESNKETANLQERSISNDDGE----EKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ 2971

Query: 1084 NALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
             ++ D    K+EQ+   EE E E +  +   T++
Sbjct: 2972 KSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRS 3005


>gi|38176300 nestin [Homo sapiens]
          Length = 1621

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 252/1168 (21%), Positives = 433/1168 (37%), Gaps = 260/1168 (22%)

Query: 415  EKSTEK--GEELKKAEGKVRKEREYVIPKRNE-----IKENKTSVSAKFSAQEIKTGLKE 467
            EK T K  GEE++++   +  +    + + N+     ++E+  ++  K   +E K  LK+
Sbjct: 542  EKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETL--KSLEKENKELLKD 599

Query: 468  VVT-------AVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQAD 520
            V         AV ++   GK   + L+  Q+   +     +  ++        N+E  + 
Sbjct: 600  VEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSS 659

Query: 521  VQMNGIPQSPLDDKKDNLDPEKESETSSQKA--PDARDN------VKDENDGCSESELEE 572
            +Q N    + L+  K+N +P +  E   ++A  P  ++N      ++DEN     S  +E
Sbjct: 660  LQENLESLTALE--KENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKE 717

Query: 573  DKQDMKTASSTSSRSHPYSSDSEDESAVG--DREAHTDSSTDESARRSSSQELSENDKPR 630
            +++ +KT             + ED+S V   + E H    + E   + + + L +  + R
Sbjct: 718  NQEPLKTL------------EEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQR 765

Query: 631  KSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGK 690
            +  L  ++ + +   ++      V+ +P+   +S +  +    E   QE  + L E+S +
Sbjct: 766  RRSLGEQDQMTLRPPEK------VDLEPL---KSLDQEIARPLENENQEFLKSLKEESVE 816

Query: 691  HVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLE--EGGKDSLPLAYVLALGAPTMNFMVD 748
             V + E E  +S            K AG   LE  +  +   PL     +    MN +  
Sbjct: 817  AVKSLETEILESL-----------KSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEK 865

Query: 749  ETA----AINSNKESQQLVQK----------TYTLEKKEAMEEDEAPQHRDADIVQGKGE 794
            E      ++  N+E+ +L+++           + LE   + EE +    R+ +  +  G+
Sbjct: 866  EIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGK 925

Query: 795  AALWGEAGAVHE--------APLRAWKPTAEQP-ELAEEFTEKREIPPGIERGAEGAAEA 845
                    ++ E        A ++ W+ T E+  ELA+E       PPG+  G E   EA
Sbjct: 926  GEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQES------PPGMA-GVENEDEA 978

Query: 846  EGVRRLGEG--GSDPI---GQAAAKDAV---GLSKDEAPE-KQALMLTVLETDKAASEGE 896
            E   R  +G  G + +   G+  A + V   G    E+PE K+   L    + K  +EG 
Sbjct: 979  ELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGL 1038

Query: 897  QGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDT 956
            Q  E                           S++  A G  A   + E+ E    D    
Sbjct: 1039 QDPE-------------------------GQSQQVGAPGLQAPQGLPEAIEPLVED---- 1069

Query: 957  GPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEG 1016
                D A   +  S E +LG E                 P  GE+ A     +E  P +G
Sbjct: 1070 ----DVAPGGDQASPEVMLGSE-----------------PAMGESAAG----AEPGPGQG 1104

Query: 1017 --SLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTD 1074
               L     L +E+V         E   E++  E        A+  +  E P+  L +  
Sbjct: 1105 VGGLGDPGHLTREEV--------MEPPLEEESLE--------AKRVQGLEGPRKDLEEAG 1148

Query: 1075 SEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPP-NEMGSDAENEAPVE 1133
                E +     K  D ++  ++ + EE E E    AEE   A      GSDA +  P+ 
Sbjct: 1149 GLGTEFSELPG-KSRDPWEPPREGR-EESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLG 1206

Query: 1134 ASELSDN-PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKD 1192
            + E  ++ P +L   S   T  PI E  PG +   E   +     G +  +EA      +
Sbjct: 1207 SEEAEEDVPPVLVSPS--PTYTPILEDAPGPQPQAEG--SQEASWGVQGRAEALGKVESE 1262

Query: 1193 REELSSRENRALKEGHRQDGEGAL-------------------------AAPEAEPAGKV 1227
            +EEL S E   + EG +++GE +                           +P  +P G+ 
Sbjct: 1263 QEELGSGE---IPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQ 1319

Query: 1228 QAP-------EGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQ-EAVAEEDP 1279
            + P       EG  PA   +E L A   +   G EG  E + G D  L  + E +  E P
Sbjct: 1320 RPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEG--EEECGRDSDLSEEFEDLGTEAP 1377

Query: 1280 IMAEKFRE--EAVDEDPEEEEDKECTLETEAMQDRNSEGDG-------DMEGEGNTQKNE 1330
             +     E  E + + P+        L   A  DR+ E DG         EGE + ++  
Sbjct: 1378 FLPGVPGEVAEPLGQVPQ-------LLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGR 1430

Query: 1331 GMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQ 1390
              G GR        G G +            GS  A   +   +      V+    W   
Sbjct: 1431 EPGAGR-------WGPGSSV-----------GSLQALSSSQRGEFLESDSVSVSVPW--D 1470

Query: 1391 DELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEE 1450
            D L G  A A K  +E  ++   E   +EE +   + E     PG LE     +    E+
Sbjct: 1471 DSLRGAVAGAPKTALETESQDSAEPSGSEEESDPVSLEREDKVPGPLE-----IPSGMED 1525

Query: 1451 GSEGQEAATGSGDGRQETGAAEKFRLGL 1478
               G +    +G G    G ++    G+
Sbjct: 1526 AGPGADIIGVNGQGPNLEGKSQHVNGGV 1553



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 163/750 (21%), Positives = 274/750 (36%), Gaps = 107/750 (14%)

Query: 776  EEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPEL-AEEFTEKREIPPG 834
            ++ E+   R   I +G+GE  +WG      E  +     ++ Q E+  EE   ++EI   
Sbjct: 480  KDGESGGSRVFSICRGEGEGQIWGL--VEKETAIEGKVVSSLQQEIWEEEDLNRKEI--- 534

Query: 835  IERGAEGAAEAEGVRRLGEGGSDPIG--QAAAKDAVGLSKDEAPEKQALMLTVLETDKAA 892
              + ++   E E ++ LGE   + +   +  + + +     E P         LE D   
Sbjct: 535  --QDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRS-------LEED--- 582

Query: 893  SEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASID 952
             E  + LEK          N E L +V  +R      E EA G +  +   +++   S+ 
Sbjct: 583  LETLKSLEKE---------NKELLKDVEVVRPL----EKEAVGQLKPTGKEDTQTLQSLQ 629

Query: 953  LEDTGPMEDTASKRE------DGSEEAILGGEEP-------AKERKEVMRTETRLSPFTG 999
             E+   M+      E        ++E +   +E         KE +E +R     SP  G
Sbjct: 630  KENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLR-----SPEVG 684

Query: 1000 EAEASRMQVSEGSPEEGSLA---KEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
            + EA R    E      SL    KEAF   E    E + T      E+D+  + P E + 
Sbjct: 685  DEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKT----LEEEDQSIVRPLETEN 740

Query: 1057 ARERRK-AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQK-----LKAEEGETETEVR 1110
             +  R   E+ + +LR  + E ++  R+   +D+   +  +K     LK+ + E    + 
Sbjct: 741  HKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLE 800

Query: 1111 AE-EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLK--ETVVPIF---EATPGFE 1164
             E +E      E   +A      E  E   + G    ++LK  ET  P++   E   G  
Sbjct: 801  NENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAM 860

Query: 1165 KSLENITALRKEGGGERLSEARDTEHKDREELSS-----RENRALKEGHRQDGEGALAAP 1219
              LE       E         R  E +++E L S      EN  L+     D E      
Sbjct: 861  NPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLEN--LRSPEEVDKESQRNLE 918

Query: 1220 EAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDP 1279
            E E  GK +  E L     + +EL              A+ Q   D V + QE   E  P
Sbjct: 919  EEENLGKGEYQESLRSLEEEGQELPQS-----------ADVQRWEDTVEKDQELAQESPP 967

Query: 1280 IMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVA 1339
             MA    E+  + +  E++      E     + N+  +  + GEG+ +  E      +V 
Sbjct: 968  GMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVE 1027

Query: 1340 VEVLHGG--------GETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQD 1391
               + GG        G++ +  A   +   G   A E  + +  +   D A  E     +
Sbjct: 1028 GASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSE 1087

Query: 1392 ELVGKTAA----------AGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKT 1441
              +G++AA           G      L R     P  EE ++      G+  P     + 
Sbjct: 1088 PAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEA 1147

Query: 1442 SGLGQE-QEEGSEGQEAATGSGDGRQETGA 1470
             GLG E  E   + ++      +GR+E+ A
Sbjct: 1148 GGLGTEFSELPGKSRDPWEPPREGREESEA 1177


>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
            sapiens]
          Length = 1782

 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 186/947 (19%), Positives = 350/947 (36%), Gaps = 142/947 (14%)

Query: 511  EKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL 570
            ++  + G  D +     Q P D      + + ES  SS + P        E   C E  L
Sbjct: 532  KQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEP--------EEITCLEKGL 583

Query: 571  EEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARR-SSSQELSENDKP 629
             E +QD +     +S       + + E            +  +  RR S S +  E DK 
Sbjct: 584  AEVQQDGEAEEGATS-----DGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV 638

Query: 630  RKSHLPIEESLEIEIEDQ-----EITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGL 684
            + + L   ES   E++++     E  K +   + +    S+E ++  G+ K         
Sbjct: 639  KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS 698

Query: 685  SEKSG-KHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLP---LAYVLALGA 740
             E+ G K +  + ++ D++          KDK+ G  G+  G ++  P    +     G+
Sbjct: 699  DEEGGPKAMGGDHQKADEAG---------KDKETGTDGILAGSQEHDPGQGSSSPEQAGS 749

Query: 741  PTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGE 800
            PT      E   +++ +  ++LV                 P+ +    ++ K E ++ G 
Sbjct: 750  PT------EGEGVSTWESFKRLV----------------TPRKKSKSKLEEKSEDSIAG- 786

Query: 801  AGAVHEAPLRAWKPTAEQPELAEEFTE-KREIPPGIERGAEGAAEAEGVRRLGEGGSDPI 859
            +G  H  P         +P   E +   K+ IP   ++  +G  E   V   G  G++  
Sbjct: 787  SGVEHSTP-------DTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANE- 838

Query: 860  GQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEV 919
              +     V LS+ +A E++ +     E  +A    EQ  +KA     +  L+   +H +
Sbjct: 839  DDSDVPAVVPLSEYDAVEREKM-----EAQQAQKSAEQPEQKAA-TEVSKELSESQVHMM 892

Query: 920  AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME----DTASKREDGSEEAIL 975
            AA              G   + + E    + I    T P+E    + A   E+  E  ++
Sbjct: 893  AAA----------VADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI 942

Query: 976  GGEEPA----------KERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLC 1025
              EEP           + R + + +E  L+P   EA  +         EEG+ A  A   
Sbjct: 943  AEEEPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEET 999

Query: 1026 KEDVEGEEMVTEAEANREDDR--KEILPKELDLARERRKAERPKTSLRKTDSEREEVTRA 1083
             E V     +T++    E+    +E+     D+  + R+ +    ++ +   E  ++   
Sbjct: 1000 TEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT 1059

Query: 1084 NALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGL 1143
                 ED  +  Q+ +AE        R EE+ +A  + +  + +    V+A E    P  
Sbjct: 1060 GG--PEDVLQPVQRAEAE--------RPEEQAEA--SGLKKETDVVLKVDAQEAKTEPFT 1107

Query: 1144 LGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRA 1203
             G+  + +T    FE  P   +S+E+             SE   T     E L+  +++ 
Sbjct: 1108 QGK-VVGQTTPESFEKAPQVTESIES-------------SELVTT--CQAETLAGVKSQE 1151

Query: 1204 LKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGG 1263
            +        +      ++E  G     +   P T Q +E+     ++      ++ G   
Sbjct: 1152 MVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEA 1211

Query: 1264 VDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGE 1323
              V  + +   A    +  E+ +E++  ED  E  DKE ++ET ++  + +EG  + +  
Sbjct: 1212 EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK-TEGTQEADQY 1270

Query: 1324 GNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER---EVLAGSETAEEKTIANKASSFSD 1380
             + +  +      V   E L G  +T  T + E+     L G  T E +   + A     
Sbjct: 1271 ADEKTKD------VPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQS 1324

Query: 1381 VAEEETWHQQDELV-----GKTAAAGKVVVEELARSGEEVPAAEEMT 1422
             A+      + E+V      KT A    V EE       V  +EE++
Sbjct: 1325 HAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVS 1371



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 219/1058 (20%), Positives = 379/1058 (35%), Gaps = 154/1058 (14%)

Query: 539  DPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDE- 597
            DP   +   + K       +   N    + EL   + D+       +     +S  E+E 
Sbjct: 43   DPAIAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEV 102

Query: 598  --SAVGDREAHTDSSTD---ESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKA 652
              + VG R++   S  D   E A +S+      +D   ++   IE+    E   +E+T+ 
Sbjct: 103  IVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP 162

Query: 653  DVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQV 712
               T+    D  F+ V K    K T  + +  +EK    V     +KD+     E  A  
Sbjct: 163  ---TESQANDIGFKKVFKFVGFKFT--VKKDKTEKPDT-VQLLTVKKDEG----EGAAGA 212

Query: 713  KDKK-AGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDET-AAINSNKESQQLVQKTYTL- 769
             D K   L   E   K+S P     +   P      +++ A I+   ES Q V++     
Sbjct: 213  GDHKDPSLGAGEAASKESEPKQ---STEKPEETLKREQSHAEISPPAESGQAVEECKEEG 269

Query: 770  EKKEAMEEDEAPQHRDADIVQGKGEAA----LWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
            E+K+  E  ++ +   + +    G         G AG   +   R  KP  ++ E +E+ 
Sbjct: 270  EEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFR--KPKEDEVEASEK- 326

Query: 826  TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
             +K + P  ++   +G AE    +      + P   A +     LS +   EK  L    
Sbjct: 327  -KKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEY--EKVELPS-- 381

Query: 886  LETDKAASEGEQGLEKAVLANEAAALNLE-HLHEVAALREAATSEEGEAEGGVAVSDVGE 944
             E   + S+G    + A LA E     +E H  EV A    +T EE   E    V +   
Sbjct: 382  -EEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAG 440

Query: 945  SEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEP------------------------ 980
            S     +   D  P E   +K     +E  + GE+P                        
Sbjct: 441  SVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV 500

Query: 981  ----AKERKEV-------MRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDV 1029
                ++ER +V       + T T L   +G+ +  +     G  +E S            
Sbjct: 501  EMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGK----RGGGDEESGEHTQVPADSPD 556

Query: 1030 EGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDE 1089
              EE   E+ A+  ++ +EI   E  LA  ++  E  + +    + +RE VT   + K  
Sbjct: 557  SQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKM 616

Query: 1090 DAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASE-LSDNPGLLGEDS 1148
               K+  +  +E  + +   + +  T +      S+ + E      E   + P    + S
Sbjct: 617  VTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTS 676

Query: 1149 LK-ETVVPIFEATPGFEKSLENITALRKEGGGERLS---EARDTEHKDREELSSRENRAL 1204
            +  E ++ +  +    +K     ++  +EGG + +    +  D   KD+E  +  +    
Sbjct: 677  VSWEALICVGSS----KKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE--TGTDGILA 730

Query: 1205 KEGHRQDGEGALAAPEAEPAGKVQAPEG----------LIPATGQAEELAAKDHDSCAGL 1254
                   G+G   +   E AG     EG          + P      +L  K  DS AG 
Sbjct: 731  GSQEHDPGQG---SSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAG- 786

Query: 1255 EGRAEGQGGVDVVLRTQEAVAEEDPIMAEKF------------REEAVDEDP----EEEE 1298
                    GV+      E   EE  +  +KF            +E+A  ED       E+
Sbjct: 787  -------SGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANED 839

Query: 1299 DKEC----------TLETEAMQDRNSEGDGDM-EGEGNTQKNEGMGGGRVVAVEVLHGGG 1347
            D +            +E E M+ + ++   +  E +  T+ ++ +   +V  +      G
Sbjct: 840  DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADG 899

Query: 1348 ETAETAAEEREV--LAGSETAEEKTIANKASSFSD-------VAEEETWHQQDELVGKTA 1398
              A T  EER    ++ S T   + +  +A+  ++       +AEEE     + L     
Sbjct: 900  TRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENRE 959

Query: 1399 AAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAA 1458
            A G  VV E   + E V AAE            G  GA E   +   +E  E        
Sbjct: 960  ARGDTVVSEAELTPEAVTAAET----------AGPLGAEEGTEASAAEETTEMVSAVSQL 1009

Query: 1459 TGSGDGRQETGAAEKFRLGLSREGERE-LSPESLQAMA 1495
            T S D  +E    ++   G+    E+E  + E LQA+A
Sbjct: 1010 TDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVA 1047



 Score = 32.7 bits (73), Expect = 2.8
 Identities = 43/195 (22%), Positives = 72/195 (36%), Gaps = 21/195 (10%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG------ 464
            K  +E      +E      K   E   V    ++I ++ +  S K    E++        
Sbjct: 1596 KEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQ 1655

Query: 465  LKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMN 524
            L+EVV   EE    G   + V EDD    L    E+     E K+ EK ++    + Q +
Sbjct: 1656 LEEVVLPSEE-EGGGAGTKSVPEDDGHALLAERIEKSLV--EPKEDEKGDDVDDPENQNS 1712

Query: 525  GIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTS 584
             +  +   D    L  E         +PD     + E +   E EL+E K   ++  + +
Sbjct: 1713 ALADT---DASGGLTKE---------SPDTNGPKQKEKEDAQEVELQEGKVHSESDKAIT 1760

Query: 585  SRSHPYSSDSEDESA 599
             ++       E ESA
Sbjct: 1761 PQAQEELQKQERESA 1775


>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
            sapiens]
          Length = 1684

 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 186/947 (19%), Positives = 350/947 (36%), Gaps = 142/947 (14%)

Query: 511  EKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL 570
            ++  + G  D +     Q P D      + + ES  SS + P        E   C E  L
Sbjct: 434  KQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEP--------EEITCLEKGL 485

Query: 571  EEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARR-SSSQELSENDKP 629
             E +QD +     +S       + + E            +  +  RR S S +  E DK 
Sbjct: 486  AEVQQDGEAEEGATS-----DGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV 540

Query: 630  RKSHLPIEESLEIEIEDQ-----EITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGL 684
            + + L   ES   E++++     E  K +   + +    S+E ++  G+ K         
Sbjct: 541  KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS 600

Query: 685  SEKSG-KHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLP---LAYVLALGA 740
             E+ G K +  + ++ D++          KDK+ G  G+  G ++  P    +     G+
Sbjct: 601  DEEGGPKAMGGDHQKADEAG---------KDKETGTDGILAGSQEHDPGQGSSSPEQAGS 651

Query: 741  PTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGE 800
            PT      E   +++ +  ++LV                 P+ +    ++ K E ++ G 
Sbjct: 652  PT------EGEGVSTWESFKRLV----------------TPRKKSKSKLEEKSEDSIAG- 688

Query: 801  AGAVHEAPLRAWKPTAEQPELAEEFTE-KREIPPGIERGAEGAAEAEGVRRLGEGGSDPI 859
            +G  H  P         +P   E +   K+ IP   ++  +G  E   V   G  G++  
Sbjct: 689  SGVEHSTP-------DTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANE- 740

Query: 860  GQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEV 919
              +     V LS+ +A E++ +     E  +A    EQ  +KA     +  L+   +H +
Sbjct: 741  DDSDVPAVVPLSEYDAVEREKM-----EAQQAQKSAEQPEQKAA-TEVSKELSESQVHMM 794

Query: 920  AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME----DTASKREDGSEEAIL 975
            AA              G   + + E    + I    T P+E    + A   E+  E  ++
Sbjct: 795  AAA----------VADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI 844

Query: 976  GGEEPA----------KERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLC 1025
              EEP           + R + + +E  L+P   EA  +         EEG+ A  A   
Sbjct: 845  AEEEPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEET 901

Query: 1026 KEDVEGEEMVTEAEANREDDR--KEILPKELDLARERRKAERPKTSLRKTDSEREEVTRA 1083
             E V     +T++    E+    +E+     D+  + R+ +    ++ +   E  ++   
Sbjct: 902  TEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT 961

Query: 1084 NALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGL 1143
                 ED  +  Q+ +AE        R EE+ +A  + +  + +    V+A E    P  
Sbjct: 962  GG--PEDVLQPVQRAEAE--------RPEEQAEA--SGLKKETDVVLKVDAQEAKTEPFT 1009

Query: 1144 LGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRA 1203
             G+  + +T    FE  P   +S+E+             SE   T     E L+  +++ 
Sbjct: 1010 QGK-VVGQTTPESFEKAPQVTESIES-------------SELVTT--CQAETLAGVKSQE 1053

Query: 1204 LKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGG 1263
            +        +      ++E  G     +   P T Q +E+     ++      ++ G   
Sbjct: 1054 MVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEA 1113

Query: 1264 VDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGE 1323
              V  + +   A    +  E+ +E++  ED  E  DKE ++ET ++  + +EG  + +  
Sbjct: 1114 EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK-TEGTQEADQY 1172

Query: 1324 GNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER---EVLAGSETAEEKTIANKASSFSD 1380
             + +  +      V   E L G  +T  T + E+     L G  T E +   + A     
Sbjct: 1173 ADEKTKD------VPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQS 1226

Query: 1381 VAEEETWHQQDELV-----GKTAAAGKVVVEELARSGEEVPAAEEMT 1422
             A+      + E+V      KT A    V EE       V  +EE++
Sbjct: 1227 HAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVS 1273



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 205/985 (20%), Positives = 354/985 (35%), Gaps = 158/985 (16%)

Query: 620  SQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQE 679
            S+++S+ D  ++         +I  + QE T   +E   +P  ES    L + TE    +
Sbjct: 14   SEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQ--IPSSESNLEELTQPTESQAND 71

Query: 680  IAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQV----KDKKAGLPGL-----------EE 724
            I     +K  K V  +   K K K  +  T Q+    KD+  G  G            E 
Sbjct: 72   IG---FKKVFKFVGFKFTVK-KDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEA 127

Query: 725  GGKDSLPLAYVLALGAPTMNFMVDET-AAINSNKESQQLVQKTYTL-EKKEAMEEDEAPQ 782
              K+S P     +   P      +++ A I+   ES Q V++     E+K+  E  ++ +
Sbjct: 128  ASKESEPKQ---STEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE 184

Query: 783  HRDADIVQGKGEAA----LWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERG 838
               + +    G         G AG   +   R  KP  ++ E +E+  +K + P  ++  
Sbjct: 185  SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFR--KPKEDEVEASEK--KKEQEPEKVDTE 240

Query: 839  AEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQG 898
             +G AE    +      + P   A +     LS +   EK  L     E   + S+G   
Sbjct: 241  EDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEY--EKVELPS---EEQVSGSQGPSE 295

Query: 899  LEKAVLANEAAALNLE-HLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTG 957
             + A LA E     +E H  EV A    +T EE   E    V +   S     +   D  
Sbjct: 296  EKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAE 355

Query: 958  PMEDTASKREDGSEEAILGGEEP----------------------------AKERKEV-- 987
            P E   +K     +E  + GE+P                            ++ER +V  
Sbjct: 356  PQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQG 415

Query: 988  -----MRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANR 1042
                 + T T L   +G+ +  +     G  +E S              EE   E+ A+ 
Sbjct: 416  SPLKKLFTSTGLKKLSGKKQKGK----RGGGDEESGEHTQVPADSPDSQEEQKGESSASS 471

Query: 1043 EDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEE 1102
             ++ +EI   E  LA  ++  E  + +    + +RE VT   + K     K+  +  +E 
Sbjct: 472  PEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSES 531

Query: 1103 GETETEVRAEEETKAPPNEMGSDAENEAPVEASE-LSDNPGLLGEDSLK-ETVVPIFEAT 1160
             + +   + +  T +      S+ + E      E   + P    + S+  E ++ +  + 
Sbjct: 532  DKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSS- 590

Query: 1161 PGFEKSLENITALRKEGGGERLS---EARDTEHKDREELSSRENRALKEGHRQDGEGALA 1217
               +K     ++  +EGG + +    +  D   KD+E  +  +           G+G   
Sbjct: 591  ---KKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE--TGTDGILAGSQEHDPGQG--- 642

Query: 1218 APEAEPAGKVQAPEG----------LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVV 1267
            +   E AG     EG          + P      +L  K  DS AG         GV+  
Sbjct: 643  SSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAG--------SGVEHS 694

Query: 1268 LRTQEAVAEEDPIMAEKF------------REEAVDEDP----EEEEDKEC--------- 1302
                E   EE  +  +KF            +E+A  ED       E+D +          
Sbjct: 695  TPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEY 754

Query: 1303 -TLETEAMQDRNSEGDGDM-EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREV- 1359
              +E E M+ + ++   +  E +  T+ ++ +   +V  +      G  A T  EER   
Sbjct: 755  DAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPS 814

Query: 1360 -LAGSETAEEKTIANKASSFSD-------VAEEETWHQQDELVGKTAAAGKVVVEELARS 1411
             ++ S T   + +  +A+  ++       +AEEE     + L     A G  VV E   +
Sbjct: 815  WISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELT 874

Query: 1412 GEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAA 1471
             E V AAE            G  GA E   +   +E  E        T S D  +E    
Sbjct: 875  PEAVTAAET----------AGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPV 924

Query: 1472 EKFRLGLSREGERE-LSPESLQAMA 1495
            ++   G+    E+E  + E LQA+A
Sbjct: 925  QEVEGGVPDIEEQERRTQEVLQAVA 949



 Score = 32.7 bits (73), Expect = 2.8
 Identities = 43/195 (22%), Positives = 72/195 (36%), Gaps = 21/195 (10%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG------ 464
            K  +E      +E      K   E   V    ++I ++ +  S K    E++        
Sbjct: 1498 KEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQ 1557

Query: 465  LKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMN 524
            L+EVV   EE    G   + V EDD    L    E+     E K+ EK ++    + Q +
Sbjct: 1558 LEEVVLPSEE-EGGGAGTKSVPEDDGHALLAERIEKSLV--EPKEDEKGDDVDDPENQNS 1614

Query: 525  GIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTS 584
             +  +   D    L  E         +PD     + E +   E EL+E K   ++  + +
Sbjct: 1615 ALADT---DASGGLTKE---------SPDTNGPKQKEKEDAQEVELQEGKVHSESDKAIT 1662

Query: 585  SRSHPYSSDSEDESA 599
             ++       E ESA
Sbjct: 1663 PQAQEELQKQERESA 1677


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 234/1210 (19%), Positives = 445/1210 (36%), Gaps = 180/1210 (14%)

Query: 406  KPSLPKSRKEKSTE-KGEEL---KKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEI 461
            KP L  +R+E+  + K EEL   K+ + KV  E E +  K  ++ E K  ++ +  A+  
Sbjct: 842  KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET- 900

Query: 462  KTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
                 E+    EEM ++    ++ LE+     + ++ E   E +EE+     NE+ +   
Sbjct: 901  -----ELFAEAEEMRARLAAKKQELEE-----ILHDLESRVEEEEERNQILQNEKKKMQA 950

Query: 522  QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNV---KDENDG-------------- 564
             +  + +   +++      + E  T+  K     + +   +D+N                
Sbjct: 951  HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010

Query: 565  CSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELS 624
            CS S+L E+++  K  +   ++     SD E+      +E  T    +++ R+   +   
Sbjct: 1011 CS-SQLAEEEEKAKNLAKIRNKQEVMISDLEERLK---KEEKTRQELEKAKRKLDGETTD 1066

Query: 625  ENDKPRKSHLPIEE-SLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQ--EIA 681
              D+  +    I+E  L++  +++E+  A        + ++  N LK   E   Q  E+ 
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN--NALKVVRELQAQIAELQ 1124

Query: 682  EGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEE--GGKDSLPLAYVLALG 739
            E    +      AE++++D S+  E    +++D        +E    ++        AL 
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184

Query: 740  APTMNFMVD--------ETAAINSNKESQQLVQKTYTLEK-KEAMEEDEAPQHRDADIVQ 790
              T N             TA    +++ +Q  +    LEK K+ +E D      +  ++Q
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244

Query: 791  ---GKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEG 847
                + E         V E   +  +    + ELAE+ ++ +     +    E  AE +G
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE-EAEKKG 1303

Query: 848  VRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV--LETDKAA--------SEGEQ 897
            ++   +  S    ++  +D   L ++E  +K  L   +  LE +K +         E  +
Sbjct: 1304 IKFAKDAASL---ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360

Query: 898  GLEKAVLANEAAALNL-----EHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASID 952
             LEK VLA ++   +      + L  + +L EA      +AE   A+S   E +  A   
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE---ALSQRLEEKALAYDK 1417

Query: 953  LEDTGPME----DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP-FTGEAEASRMQ 1007
            LE T        D  +   D   +     E+  K+  +++  E  +S  +  E + +  +
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477

Query: 1008 VSEGSPEEGSLAK---EAFLCKEDVEGEEMVTEAE-----ANREDDRKEILPKELDLARE 1059
              E   +  SLA+   EA   KE+ E +     A+     ++++D  K +   E      
Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRAL 1537

Query: 1060 RRKAERPKTSLRKTDSEREEVTRANA----------------LKDEDAFKEEQKLKAEEG 1103
             ++ E  +T L + + E +    A                  L+  D   EE+K    + 
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597

Query: 1104 ETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGF 1163
              E E   E+E K     + S  + E  ++  E          D + + +  +      +
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657

Query: 1164 EKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEP 1223
            ++ LE   A R E   +     +  +  + E L  +E  A  E  R+  E          
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE---------- 1707

Query: 1224 AGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEED----P 1279
                           + +ELA +  +S +G     + +  ++  +   E   EE+     
Sbjct: 1708 --------------QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1753

Query: 1280 IMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD----------MEGEGNTQKN 1329
            ++ ++FR+  +  D         TL  E   +R++    D           E +   Q+ 
Sbjct: 1754 LLNDRFRKTTLQVD---------TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL 1804

Query: 1330 EGMGGGRVVA-VEVLHGG-GETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETW 1387
            EG    +  A +  L    G+  E   +E +  A +     +T       F  V E+E  
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV-EDERR 1863

Query: 1388 H--QQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLG 1445
            H  Q  E + K  A  K +  +L  + EE   A                 A  RK     
Sbjct: 1864 HADQYKEQMEKANARMKQLKRQLEEAEEEATRA----------------NASRRKLQREL 1907

Query: 1446 QEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTE 1505
             +  E +EG      +   R   G    F    SR G R+L  E     A+L +  D TE
Sbjct: 1908 DDATEANEGLSREVSTLKNRLRRGGPISF--SSSRSGRRQLHLEG----ASLELSDDDTE 1961

Query: 1506 TREKQQHMVQ 1515
            ++    +  Q
Sbjct: 1962 SKTSDVNETQ 1971


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 189/939 (20%), Positives = 345/939 (36%), Gaps = 94/939 (10%)

Query: 405  KKPSLPKSRKEKSTE--KGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462
            ++  L + ++E+  +  K EE+++ E + R+E+     KR E +E +     K   QE +
Sbjct: 586  RQQRLKREQEERLEQRLKREEVERLEQEERREQRL---KREEPEEERRQQLLKSEEQEER 642

Query: 463  TGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQ 522
               ++ +   ++   + +  +E  E+  E  LK E+EE  E  E++  E+  E+ +  ++
Sbjct: 643  R--QQQLRREQQERREQRLKREEEEERLEQRLKREHEE--ERREQELAEEEQEQARERIK 698

Query: 523  MNGIP--QSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL---EEDKQDM 577
               IP  Q  L+ + D    +  S    Q+    R   ++E     ESEL   EE++   
Sbjct: 699  SR-IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE-QEEKRRRRESELQWQEEERAHR 756

Query: 578  KTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIE 637
            +       R   +   +E++S  G +         E   R    E  E  +  +  LP E
Sbjct: 757  QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE--ERQQREQRFLPEE 814

Query: 638  ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697
            E  E     Q   +     K +   E  E + +    +  QE  +GL E   +  S E++
Sbjct: 815  EEKE-----QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869

Query: 698  EKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNK 757
             +D+   W+               LEE  K      Y              + A     +
Sbjct: 870  -RDQKWRWQ---------------LEEERKRRRHTLYA-------------KPALQEQLR 900

Query: 758  ESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAE 817
            + QQL+Q+    E++E   E+   + R     Q + E  L  E     E  LR  +    
Sbjct: 901  KEQQLLQE----EEEELQREEREKRRRQEQERQYREEEQLQQE----EEQLLREEREKRR 952

Query: 818  QPELAEEFTEKREIPPGIER--GAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEA 875
            + E   ++ + +++    E+  G E        R       + + Q   ++ +   + E 
Sbjct: 953  RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE--EEQLLREEREK 1010

Query: 876  PEKQALMLTVLETDKAASEGEQGL----EKAVLANEAAALNLEHLHEVAALREAATSEEG 931
              +Q       + D+   E EQ L    EK  L         E   E+    E    EE 
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE--ELQQEEEQLLGEER 1068

Query: 932  EAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTE 991
            E      +      EEE  +  E+   + +   KR     E     EE  ++ +E +  E
Sbjct: 1069 ETRRRQELERQYRKEEE--LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126

Query: 992  TRLSPFTGEAEASRMQVSEGSPEEGSLAKEA------------FLCKEDVEGEE--MVTE 1037
             R      E E    +  E   EE  L +E             +  +E+++ EE  ++ E
Sbjct: 1127 EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE 1186

Query: 1038 AEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQK 1097
             +  R  +R+    +E +L R++RK        R     + E  + NA++D   + + ++
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246

Query: 1098 LKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIF 1157
             +      ++++R  +  +   + +G   E +   E            E+   E      
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ-K 1305

Query: 1158 EATPGFEKSLENITALRKEGGGERLSEARDTEHKDREE-LSSRENRALKEGHRQDGEGAL 1216
            EA     KS E    LR+E   +R  +  D + ++ E+ L  RE + L+   RQ+ +   
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR---RQERDRKF 1362

Query: 1217 AAPEA--EPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAV 1274
               E   +  G+    E       + E    K+       E   + +   D   R +E  
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ 1422

Query: 1275 AEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRN 1313
                     KFREE      +E E K    E +  Q+R+
Sbjct: 1423 LSRQE-RDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 212/1074 (19%), Positives = 387/1074 (36%), Gaps = 160/1074 (14%)

Query: 411  KSRKEKSTEKGEELKKAEGKV-RKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVV 469
            +  +E+   + E+L++ E ++ R+ERE    +R + +E +     K   +E +   +E  
Sbjct: 923  RQEQERQYREEEQLQQEEEQLLREERE---KRRRQERERQYRKDKKLQQKEEQLLGEEPE 979

Query: 470  TAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQM--NGIP 527
                +   K    +E L+ ++E  L+ E E+    + E+Q  K +E  Q + Q+      
Sbjct: 980  KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039

Query: 528  QSPLDDKKDNLDPEKESETSSQKA----PDARDNVKDENDGCSESELEEDKQDMKTASST 583
            +  L +++     E+E +   ++      + R   + E     E EL+++++ +      
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099

Query: 584  SSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIE 643
              R         +E  +   E        E  RR   QEL    +  +     EE L  E
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRR---QELERQYREEEEVQQEEEQLLRE 1156

Query: 644  IED----QEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEK 699
              +    QE+ +   E + +  +E  E +L+E  EK  QE       +  ++   EE ++
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEE--EQLLREEQEKRRQE-------RERQYREEEELQR 1207

Query: 700  DKSKLWEESTAQVKDKK-AGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKE 758
             K K       Q  D K    P  E   +D+     V   G     F   E + +   + 
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK----VYCKGRENEQFRQLEDSQLRDRQS 1263

Query: 759  SQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQ 818
             Q L       ++++  +E    Q RD                            P  EQ
Sbjct: 1264 QQDLQHLLGEQQERDREQERRRWQQRDRHF-------------------------PEEEQ 1298

Query: 819  PELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEK 878
             E  E+   KR                                  +++   L ++E  EK
Sbjct: 1299 LEREEQKEAKRR------------------------------DRKSQEEKQLLREEREEK 1328

Query: 879  QALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVA 938
            +       ETD+   E EQ L++     E   L  +         E    E+G       
Sbjct: 1329 RRRQ----ETDRKFREEEQLLQE----REEQPLRRQERDRKFREEELRHQEQGR------ 1374

Query: 939  VSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFT 998
               + E +     + E     E+   + ++  ++     +   +E ++ +  + R   F 
Sbjct: 1375 -KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433

Query: 999  GEAEASRMQVSEGS--PEEGSLAKEAFLCKEDVEGEEMVTEAEA---NREDDRKEILPKE 1053
             E +  R Q  E     EE  L +E    ++  E E+++ E E    +R++  ++ L +E
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERH--RKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491

Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANAL----KDEDAFKEEQKLKAEEGETETEV 1109
              L R+ R  +  +  LR  + ER+ +     L    +     +EEQ+L+ +E   +   
Sbjct: 1492 QQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR-- 1549

Query: 1110 RAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLEN 1169
            R + + K    E       E  +   E  D    L E  ++              K +E+
Sbjct: 1550 RQDRDRKFREEEQLRQEREEQQLSRQE-RDRKFRLEEQKVRRQEQE--------RKFMED 1600

Query: 1170 ITALRKEGGGERLSEARDTEHKDREE-LSSRENRALKEGHRQDGEGALAAPEAEPAGKVQ 1228
               LR++ G ++L + RD + ++ E+ L  RE + L   HRQ+ +      E EP  + Q
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL---HRQERDRKFL--EEEPQLRRQ 1655

Query: 1229 APEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREE 1288
                      + E+    D D     E +   Q G +  LR QE           KFREE
Sbjct: 1656 ----------EREQQLRHDRDRKFREEEQLL-QEGEEQQLRRQE--------RDRKFREE 1696

Query: 1289 AVDEDPEEEEDK----ECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLH 1344
                  +E E K    E  L  + ++ +  E +   +     Q        +++  E L 
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756

Query: 1345 GGGETAETAAEEREVLAGSE-----TAEEKTIANKASSFSDVAEEETWHQQDE-LVGKTA 1398
               E  +   +ER+     E       EE+ + ++ S      EE+   +++E  +    
Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ 1816

Query: 1399 AAGKVVVEE--LARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEE 1450
              GK   EE  L    +E    +E    Y  E    T     R+   L QE+E+
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ 1870



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 178/995 (17%), Positives = 360/995 (36%), Gaps = 132/995 (13%)

Query: 402  GLDKKPSLPKSRKEK--STEKGEELKKAEGKVRKEREYVI---PKRNEIKENKTSVSAKF 456
            G ++K    + R+++    E+ +E +K E  +RKE E +    P+R    + +     K 
Sbjct: 222  GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281

Query: 457  SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEE 516
              QE++   +E     EE        Q+ L  +Q+   K E EE  E  EE++ ++   E
Sbjct: 282  ERQELRRERQE-----EEQQ------QQRLRREQQLRRKQE-EERREQQEERREQQERRE 329

Query: 517  GQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEED--- 573
             Q + +   + +   + ++  L  E+E E   Q+    ++  + E     E +L  +   
Sbjct: 330  QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389

Query: 574  --------------------------------KQDMKTASSTSSRSHPYSSDSEDESAVG 601
                                            +Q ++           +  +  ++    
Sbjct: 390  RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449

Query: 602  DREAHTD-------SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADV 654
            ++E   D       +   E  RR    +  + ++ R+  L +EE  E   E QE  +  +
Sbjct: 450  EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE--EERREQQERREQQL 507

Query: 655  ETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKD 714
              +    +E  E  LK   E+  + + + L  +       EE+ +   K  EE   + + 
Sbjct: 508  RREQ---EERREQRLKRQEEE--ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562

Query: 715  KKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEA 774
            ++  L   +E  +D L                 +E       +E ++ +++    E+ E 
Sbjct: 563  REQRLKREQEERRDQLLK-------------REEERRQQRLKREQEERLEQRLKREEVER 609

Query: 775  MEEDEAPQHR--DADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIP 832
            +E++E  + R    +  + + +  L  E     +   R  +   EQ E  E+  ++ E  
Sbjct: 610  LEQEERREQRLKREEPEEERRQQLLKSE----EQEERRQQQLRREQQERREQRLKREEEE 665

Query: 833  PGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSK------DEAPEKQALMLTVL 886
              +E+  +   E E  RR  E   +   QA  +    + K       EA  +Q+ +    
Sbjct: 666  ERLEQRLKREHEEE--RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY--- 720

Query: 887  ETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSE-------EGEAEGGVAV 939
             +     EG++  ++           L+   E  A R+    E       + +AE     
Sbjct: 721  -SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE---EK 776

Query: 940  SDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTG 999
            S+ G     A   L +    +  A +R+   E+  L  EE  ++R+   R   +   F  
Sbjct: 777  SERGRQRLSARPPLREQRERQLRAEERQQ-REQRFLPEEEEKEQRRRQRREREKELQFLE 835

Query: 1000 EAE--ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
            E E    R +  +   EE  L ++    +   +  +     +   E  R+          
Sbjct: 836  EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895

Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            +E+ + E+      + + +REE  +    + E  ++EE++L+ EE +   E R +   + 
Sbjct: 896  QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955

Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEG 1177
               +   D + +   E   L + P        ++      E     E+ L      R+  
Sbjct: 956  RERQYRKDKKLQQK-EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014

Query: 1178 GGERLSEARDTEHKDREEL--SSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
              ER    +D   ++ E+L    RE R L+E  RQ  E            ++Q  E    
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE----------EEELQQEE---- 1060

Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPE 1295
                 E+L  ++ ++    E   + +   ++    ++ + EE      + RE    E+ E
Sbjct: 1061 -----EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115

Query: 1296 EEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNE 1330
             ++++E  L  E  + R  E +     E   Q+ E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 167/802 (20%), Positives = 304/802 (37%), Gaps = 72/802 (8%)

Query: 757  KESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGA--VHEAPLRAWK- 813
            ++ ++L +     EK+E +E+ +  Q RD ++ + + E   W E       E  L++ K 
Sbjct: 143  EQERELAEGEEQSEKQERLEQRDR-QRRDEELWRQRQE---WQEREERRAEEEQLQSCKG 198

Query: 814  -PTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGG--SDPIGQAAAKDAVGL 870
              T E P+  EE   +RE+   +E   +G  E +  RR  +     +   +   K    L
Sbjct: 199  HETEEFPD--EEQLRRREL---LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253

Query: 871  SKDEA------PEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALRE 924
             K+E       P++Q  +    E  +     E   E+     +   L  E         E
Sbjct: 254  RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313

Query: 925  AATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKER 984
                +E   E         E  E+     ++    +    ++E+   E  L  E+  + R
Sbjct: 314  RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373

Query: 985  KEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDV--EGEEMVTEAEANR 1042
            ++ +R E +L          +++  +    E  L +E  L +E      +++  E E  R
Sbjct: 374  EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433

Query: 1043 EDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANAL--KDEDAFKEEQKLKA 1100
             + + E   +E  L RE+   ER     R+ ++ER E  R      +D++  + E+ LK 
Sbjct: 434  HEQKHEQERREQRLKREQE--ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491

Query: 1101 EEGET-ETEVRAEEETKAPPNEMGSDA----ENEAPVEASELSDNPGLLGEDSLKETVVP 1155
            EE E  E + R E++ +    E         E E  ++    S+      ++  +E ++ 
Sbjct: 492  EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551

Query: 1156 IFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGA 1215
              E     EK LE     R+E   +R  E R  +   REE   R  + LK    +  E  
Sbjct: 552  REE-----EKRLEQE---RREQRLKREQEERRDQLLKREE--ERRQQRLKREQEERLEQR 601

Query: 1216 LAAPEAEPAGKVQAPEGLIPATGQAEE-----LAAKDHDSCAGLEGRAEGQGGVDVVLRT 1270
            L   E E   + +  E  +      EE     L +++ +     + R E Q   +  L+ 
Sbjct: 602  LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661

Query: 1271 QEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNE 1330
            +E     +  +  +  EE  +++  EEE ++     E ++ R  +    +E E + ++++
Sbjct: 662  EEEEERLEQRLKREHEEERREQELAEEEQEQAR---ERIKSRIPKWQWQLESEADARQSK 718

Query: 1331 GMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETA-EEKTIANKASSFSDVAEEETWHQ 1389
                 R          G+      EE+     SE   +E+  A++     +   + TW  
Sbjct: 719  VYSRPRKQE-------GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771

Query: 1390 QDELVGKTA----AAGKVVVEELARS--GEEVPAAEEMTVTYTTEAGVGTPGALERKTSG 1443
            Q E   +      +A   + E+  R    EE    E+  +    E         ER+   
Sbjct: 772  QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831

Query: 1444 LGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERE------LSPESLQAMATL 1497
               E+EE  + +E A    +  +E G  E      S+E  R+      L  E  +   TL
Sbjct: 832  QFLEEEEQLQRRERAQQLQE--EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889

Query: 1498 PVKPDFTETREKQQHMVQGESE 1519
              KP   E   K+Q ++Q E E
Sbjct: 890  YAKPALQEQLRKEQQLLQEEEE 911



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 166/846 (19%), Positives = 318/846 (37%), Gaps = 102/846 (12%)

Query: 414  KEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVE 473
            +E+  ++ E+L + E + R+ +E     R E +  +         QE +   +E     E
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202

Query: 474  EMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDD 533
            E   + K  Q   ++DQ + LK+++E   E +   +  K   +G+ + Q   +  S L D
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEP--EKENAVRDNKVYCKGRENEQFRQLEDSQLRD 1260

Query: 534  KKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSD 593
            ++   D +       ++  +       + D     E + ++++ K A     +S      
Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320

Query: 594  SEDESAVGDREAHTDSSTDESAR---RSSSQELSENDKPRKSHLPIEESLEIEIEDQEIT 650
              +E     R   TD    E  +       Q L   ++ RK     EE L  + + ++  
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR---EEELRHQEQGRKFL 1377

Query: 651  KADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKE---KDKSKLWEE 707
            + +   +    +  F   LKE  +   QE  + L +   +    EE++   +++ + + E
Sbjct: 1378 EEEQRLRRQERERKF---LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434

Query: 708  STAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTY 767
               QV+ ++     LEE  +  L                          +E +QL+Q   
Sbjct: 1435 EEQQVRRQERERKFLEE--EQQL------------------RQERHRKFREEEQLLQ--- 1471

Query: 768  TLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTE 827
                 E  E+    Q RD   ++ + +           E  LR+ +P  E+  L EE   
Sbjct: 1472 -----EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP--ERKFLEEEQQL 1524

Query: 828  KREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP---EKQALMLT 884
             R+     +R  +   E + +RR   G      Q   +D     ++E     E++   L+
Sbjct: 1525 HRQ-----QRQRKFLQEEQQLRRQERG------QQRRQDRDRKFREEEQLRQEREEQQLS 1573

Query: 885  VLETDKAASEGEQGL-----EKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
              E D+     EQ +     E+  + +E      E   ++   R+    E+ +       
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL------ 1627

Query: 940  SDVGESEEEASIDLE-DTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFT 998
              + E EE+     E D   +E+    R    E+ +        +R    R E +L    
Sbjct: 1628 --LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL------RHDRDRKFREEEQLLQEG 1679

Query: 999  GEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLAR 1058
             E +  R +      EE    +     ++ ++ E+ +   E  R+   +E L +E +  +
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739

Query: 1059 ERRKAERPKTSLRKTD--SEREEVTRANALKDEDAFKEEQKLKAE-------EGETETEV 1109
             RR+ ER +  L +     EREE       +D   F+EE++L+ E         E++ + 
Sbjct: 1740 LRRQ-ERYRKILEEEQLRPEREEQQLRRQERDRK-FREEEQLRQEREEQQLRSQESDRKF 1797

Query: 1110 RAEEETKAPPNE-----MGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFE 1164
            R EE+ +    E        D +     E  +L +    L ++  ++       AT   E
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ--E 1855

Query: 1165 KSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPA 1224
            KS      L +E   E     ++ E K REE   R+ +  ++ HRQ GE  + + E +  
Sbjct: 1856 KSRREEQELWQE---EEQKRRQERERKLREEHIRRQQKE-EQRHRQVGE--IKSQEGKGH 1909

Query: 1225 GKVQAP 1230
            G++  P
Sbjct: 1910 GRLLEP 1915



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 153/765 (20%), Positives = 264/765 (34%), Gaps = 116/765 (15%)

Query: 567  ESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSEN 626
            E +   + +D +       R      + E E A G+ ++      ++  R+   +EL   
Sbjct: 117  EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWR- 175

Query: 627  DKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFEN-VLKEGTEKGTQEIAEGLS 685
               ++      E    E E  +  K   ET+  P +E      L E   KG +E  +   
Sbjct: 176  ---QRQEWQEREERRAEEEQLQSCKGH-ETEEFPDEEQLRRRELLELRRKGREEKQQQRR 231

Query: 686  EKSGKHVSAEEKE----------KDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYV 735
            E+  +    EE++          K++ KL EE   + ++ +     L +  +  L     
Sbjct: 232  ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL----- 286

Query: 736  LALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEA 795
                                 ++ QQ +++   L +K+  EE+   Q  +    Q + E 
Sbjct: 287  --------------RRERQEEEQQQQRLRREQQLRRKQ--EEERREQQEERREQQERRE- 329

Query: 796  ALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGG 855
                +     E  LR  +    + +L  E  E+R     + R  E     + +RR     
Sbjct: 330  ----QQEERREQQLRREQEERREQQLRREQEEERR-EQQLRREQEEERREQQLRREQ--- 381

Query: 856  SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEH 915
                 Q   +  +   +    E+Q      L  ++     +Q   +  L  E      E 
Sbjct: 382  -----QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436

Query: 916  LHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAIL 975
             HE     +    E+ E        D  + EEE     ++    +    + E+  E  + 
Sbjct: 437  KHEQERREQRLKREQEERR------DWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490

Query: 976  GGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMV 1035
              EE  +E++E    + R      E E  R Q  +   EE  L +   L  E    +++ 
Sbjct: 491  LEEEERREQQERREQQLRR-----EQEERREQRLKRQEEEERLQQR--LRSE----QQLR 539

Query: 1036 TEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEE 1095
             E E  RE   K    K L+  R  ++ +R +   R    +REE  R   LK E   + E
Sbjct: 540  REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599

Query: 1096 QKLKAEEGE-TETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVV 1154
            Q+LK EE E  E E R E+  K            E P E            +  LK    
Sbjct: 600  QRLKREEVERLEQEERREQRLK-----------REEPEEERR---------QQLLKSE-- 637

Query: 1155 PIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEG 1214
                     E+       LR+E       E R+   K  EE    E R  +E   +  E 
Sbjct: 638  ---------EQEERRQQQLRRE-----QQERREQRLKREEEEERLEQRLKREHEEERREQ 683

Query: 1215 ALAAPEAEPAG---KVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQ 1271
             LA  E E A    K + P+       +A+   +K +      EG+   Q         +
Sbjct: 684  ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ-------EQE 736

Query: 1272 EAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEG 1316
            E     +  +  +  E A  +  EEE+ ++ T + +A ++++  G
Sbjct: 737  EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA-EEKSERG 780


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 223/1076 (20%), Positives = 406/1076 (37%), Gaps = 163/1076 (15%)

Query: 523  MNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASS 582
            ++G P SP+ D      P+ +     ++  D R N +DE     E EL E+++ +     
Sbjct: 197  LSGSPASPMGDILQT--PQFQMRRLKKQLADERSN-RDE----LELELAENRKLL----- 244

Query: 583  TSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSS----QELSE-NDKPRKSHLPIE 637
                       +E ++ +   +   D     + ++++S    +EL E  DK     + + 
Sbjct: 245  -----------TEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293

Query: 638  ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGT--QEIAEGLSEKSGKHVSAE 695
            E+L+ + +D +  K+ ++ K   + E   ++  +  E  +  Q++ + L+E + +H  A 
Sbjct: 294  ETLK-QCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKAT 352

Query: 696  EKEKDK-SKLWEESTAQVKDKKA----------GLPGLEEGG---KDSLPLAYVLALGAP 741
            ++  +K ++L +E +A ++DKK            L  LEE     +D+ P      LG  
Sbjct: 353  QEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLG-- 410

Query: 742  TMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEA 801
                  D        +E+  L      L+ +  M E E          +G+ EA L  E 
Sbjct: 411  ------DVLQLETLKQEAATLAANNTQLQARVEMLETE----------RGQQEAKLLAER 454

Query: 802  GAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG---AAEAEGVRRLGEGGS-- 856
            G   E          E+ +L+   T+ +     + +  E    A++A G R   +  S  
Sbjct: 455  GHFEE----------EKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT 504

Query: 857  ------DPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAA 910
                  +   Q   ++  GL K +A EKQA +   L+  + AS+G        L ++   
Sbjct: 505  SELTTLNATIQQQDQELAGL-KQQAKEKQAQLAQTLQQQEQASQG--------LRHQVEQ 555

Query: 911  LNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGS 970
            L+     +   L+E A  +E   +           E EAS+   D    +  A ++E  +
Sbjct: 556  LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615

Query: 971  EEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVE 1030
            +  IL       +++  +  E R S  T   +A R +       E   A      +E  E
Sbjct: 616  KLEIL-------QQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHE 668

Query: 1031 GEEMVTEAEANREDDR-----KEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANA 1085
             +  V E E     ++     KE + +E D  +E+ +A +    + K   E E+   A+A
Sbjct: 669  AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728

Query: 1086 LKDEDAFKEEQKL---------KAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASE 1136
            L+++     E K          K E  E E E    +  +A   ++G   + E  V   E
Sbjct: 729  LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE 788

Query: 1137 LSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGG---ERLSEARDTEHKDR 1193
            L++   +  + + +     + +    + +  E+      + G    E+L   ++   K R
Sbjct: 789  LAE--AMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846

Query: 1194 EEL-SSRENRALKEGH------RQDGEGA-LAAPEAEPAGKVQAPEGLIPATGQAEELAA 1245
            +EL  ++E  A  E H      RQ  E A L A  A    +VQ  E  + A   A++L+ 
Sbjct: 847  QELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKE--VRAQKLADDLST 904

Query: 1246 KDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP---EEEEDKEC 1302
                  A  +  A  +  V      QE  + E  ++ E  R  A D  P   EE++ ++ 
Sbjct: 905  LQEKMAATSKEVARLETLVRKAGEQQETASRE--LVKEPAR--AGDRQPEWLEEQQGRQF 960

Query: 1303 TLETEAMQ--DRNSEGDGD---------MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAE 1351
                 A+Q  +R +E  G+         ME +G  Q+  G     V    +    G    
Sbjct: 961  CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--ARLTQERGRAQA 1018

Query: 1352 TAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKV------VV 1405
              A E+   A  E   +  +  +   F+ + +E   H   E  GK     K+       +
Sbjct: 1019 DLALEKAARAELEMRLQNALNEQRVEFATL-QEALAHALTEKEGKDQELAKLRGLEAAQI 1077

Query: 1406 EELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGR 1465
            +EL    + V   +E       E   G+    + + +G  +      E   A     + +
Sbjct: 1078 KELEELRQTVKQLKEQLAKKEKEHASGS--GAQSEAAGRTEPTGPKLEALRAEVSKLEQQ 1135

Query: 1466 QETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTETREKQQHMVQGESETA 1521
             +    +   L  S E ER    E   A+ TL       +  EK Q +   +S  A
Sbjct: 1136 CQKQQEQADSLERSLEAERASRAERDSALETLQ-----GQLEEKAQELGHSQSALA 1186



 Score = 39.3 bits (90), Expect = 0.030
 Identities = 143/710 (20%), Positives = 271/710 (38%), Gaps = 72/710 (10%)

Query: 497  EYEEDFEVDEEKQGEKSNEEG--QADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDA 554
            + +E+    E +    + E G  QAD+ +    ++ L+ +  N   E+  E ++ +   A
Sbjct: 994  QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053

Query: 555  RDNVKDEN-----------DGCSESELEEDKQDMKTASST-SSRSHPYSSDSEDESAVGD 602
                + E            +     ELEE +Q +K      + +   ++S S  +S    
Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113

Query: 603  REAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPID 662
            R   T     E+ R   S+   +  K ++    +E SLE E   +    + +ET    ++
Sbjct: 1114 RTEPTGPKL-EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172

Query: 663  ESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGL 722
            E  +       E G  + A  L+    +  +   K +D SK  +E  AQV   +      
Sbjct: 1173 EKAQ-------ELGHSQSA--LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ----- 1218

Query: 723  EEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQ 782
            E   K+SL  +  L      +N  V E      +KE ++LV      E +++ + +E  +
Sbjct: 1219 EAERKNSLISS--LEEEVSILNRQVLEKEG--ESKELKRLVMA----ESEKSQKLEERLR 1270

Query: 783  HRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGA 842
               A+       AA   E  +     +++ +  AE+  +A E   ++E+    ER  E  
Sbjct: 1271 LLQAETASNSARAA---ERSSALREEVQSLREEAEKQRVASE-NLRQELTSQAERAEELG 1326

Query: 843  AEAEGVRRLGEGGSDPIG--QAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900
             E +  +         +   Q        L  +  P K   +   L+ ++AA+E     E
Sbjct: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH--LCQQLQAEQAAAEKRHREE 1384

Query: 901  KAVLANEAAALNLE------HLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLE 954
                   A  L  E       L E+  LR+    +E  A+   A  +     E+ S+  +
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRA--EKASYAEQLSMLKK 1442

Query: 955  DTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETR-LSPFTGEAEASRMQVSEGSP 1013
              G +   A +     E A LG +    E  +      + L+    +AE    +++E   
Sbjct: 1443 AHGLL---AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET---RLAEVQR 1496

Query: 1014 EEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT 1073
            E  S A+E  +     EG ++    E  R  + ++ L  ++         E+ +   R+ 
Sbjct: 1497 EAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV---------EQLEVFQREQ 1547

Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSD-AENEAPV 1132
              + EE+++  A  D+ +  ++QKLKA + +     +  +  +A  NE+ +  ++ E   
Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAA 1607

Query: 1133 EASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERL 1182
            E  +L         D+ K+    + E     E+  +    LR E   ERL
Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAE--AERL 1655


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 180/957 (18%), Positives = 383/957 (40%), Gaps = 80/957 (8%)

Query: 403  LDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462
            L+ K      R E+  E   EL   + K+  E   +    ++++     V  +  A E K
Sbjct: 918  LEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 977

Query: 463  T-GLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
               L E +  ++E  +K    ++ L++  + TL     +D + +E+K    +  + + + 
Sbjct: 978  VKNLTEEMAGLDETIAKLSKEKKALQETHQQTL-----DDLQAEEDKVNILTKAKTKLEQ 1032

Query: 522  QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTAS 581
            Q++ +  S   +KK  +D E+           A+++  D  +   + + + +K++ + ++
Sbjct: 1033 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISN 1092

Query: 582  STSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLE 641
              S      + + + +  + + +A  +   +E     +S+  +E  +   S   +EE  E
Sbjct: 1093 LISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSR-ELEEISE 1151

Query: 642  IEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDK 701
               E    T A VE       E+    L+   E+ T +    ++    KH  +  +  ++
Sbjct: 1152 RLEEAGGATSAQVELNKK--REAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQ 1209

Query: 702  SKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALG--APTMNFMVDETAAINSNKES 759
                +    +++ +K+ L  +E     S   A   A G        + D+ + + + +E 
Sbjct: 1210 IDNLQRVKQKLEKEKSELK-METDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEE 1268

Query: 760  QQLVQKTYTLEKKEAMEE--DEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAE 817
            QQ +    T ++     E  + + Q  + D +  +   +       + E   +  + T  
Sbjct: 1269 QQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKA 1328

Query: 818  QPELAEEFTEKRE----IPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAK---DAVGL 870
            +  LA      R     +    E   EG AE +  R L +  S+ + Q   K   DA+  
Sbjct: 1329 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQ--RALSKANSE-VAQWRTKYETDAIQR 1385

Query: 871  SK--DEAPEKQALMLTVLETDKAASEGE-QGLEKAV--LANEAAALNLEHLHEVAALREA 925
            ++  +EA +K A  L   E    A   +   LEK    L NE   L L+     AA    
Sbjct: 1386 TEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAA---C 1442

Query: 926  ATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEA----ILGGEEPA 981
            A  ++ +      +S+  +  EE   +LE        AS++E  S       +    E +
Sbjct: 1443 AALDKKQRNFDKVLSEWKQKYEETQAELE--------ASQKESRSLSTELFKVKNVYEES 1494

Query: 982  KERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK-EAFLCKEDVEGEEMVTEAEA 1040
             ++ E +R E +      E      Q++EG  +   L K +  + +E  E +  + EAEA
Sbjct: 1495 LDQLETLRRENK--NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552

Query: 1041 NREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTR--------------ANAL 1086
            + E +  +IL  +L+L + + + +R    + + D E +++ R              A   
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQLKRNHTRVVETMQSTLDAEIR 1609

Query: 1087 KDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGE 1146
               DA + ++K++ +    E E++     +     + +    +  ++ ++L  +  L G+
Sbjct: 1610 SRNDALRVKKKMEGD--LNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQ 1667

Query: 1147 DSLKETVVPIFEATPGFEKSLENITA-LRKEGGGERLSEARDTEHKDREELSSRENRALK 1205
            + LKE +  +       +  +E + A L +     +++E    +  +R +L   +N +L 
Sbjct: 1668 EDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1727

Query: 1206 EGHRQ-DGEGALAAPEAEPA------GKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRA 1258
               ++ + + +    E E         + +A + +  A   AEEL  K+ D+ A LE   
Sbjct: 1728 NTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEEL-KKEQDTSAHLERMK 1786

Query: 1259 EGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSE 1315
            +    ++  ++  +   +E   +A K  ++ + +   E   +E   E E  Q RN+E
Sbjct: 1787 K---NLEQTVKDLQHRLDEAEQLALKGGKKQIQK--LEARVRELEGEVENEQKRNAE 1838



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 156/775 (20%), Positives = 298/775 (38%), Gaps = 96/775 (12%)

Query: 399  IAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSA 458
            + + L KK    ++R E+  E+ E  + +  K  K+R  +  +  EI E         SA
Sbjct: 1103 VEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSA 1162

Query: 459  QEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQ 518
            Q            VE    +    Q++  D +E TL  ++E       +K  +   E G+
Sbjct: 1163 Q------------VELNKKREAEFQKLRRDLEEATL--QHEAMVAALRKKHADSMAELGE 1208

Query: 519  ADVQMNGIPQSPLDDKKDNLDPEKESETSSQKA-PDARDNV----KDENDGCSESELEED 573
                +  + Q  L+ +K  L  E +  +S+ +A   A+ N+    +   D  SE + +E+
Sbjct: 1209 QIDNLQRVKQK-LEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEE 1267

Query: 574  KQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSE----NDKP 629
            +Q       T+ R+   +   E    + +++A    S    ++++S+Q++ E     ++ 
Sbjct: 1268 EQQRLINDLTAQRARLQTEAGEYSRQLDEKDALV--SQLSRSKQASTQQIEELKHQLEEE 1325

Query: 630  RKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSG 689
             K+   +  +L+    D ++ +   E      ++  +  L+    K   E+A+  ++   
Sbjct: 1326 TKAKNALAHALQSSRHDCDLLREQYEE-----EQEGKAELQRALSKANSEVAQWRTKYET 1380

Query: 690  KHVS-AEEKEKDKSKL---WEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNF 745
              +   EE E+ K KL    +E+   V+   A    LE+  +        L L     N 
Sbjct: 1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSN- 1439

Query: 746  MVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVH 805
                 AA++  + +   V   +  + +E   E EA Q     +        L+       
Sbjct: 1440 --AACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL-----STELFKVKNVYE 1492

Query: 806  EAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAK 865
            E+  +      E   L +E ++  E    I  G +   E E +++  E     I QAA +
Sbjct: 1493 ESLDQLETLRRENKNLQQEISDLTE---QIAEGGKQIHELEKIKKQVEQEKCEI-QAALE 1548

Query: 866  DAVGLSKDEAPEKQALMLTV----LETDKAASEGEQGLEK------AVLANEAAALNLEH 915
            +A    + E  +   + L +     E D+  +E ++ +++       V+    + L+ E 
Sbjct: 1549 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEI 1608

Query: 916  LHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDT-GPMEDTASKREDGSEEAI 974
                 ALR     E    E  + ++       E+  +  +T G +++T    +D      
Sbjct: 1609 RSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA----- 1663

Query: 975  LGGEEPAKERKEVMRTETRLSPFTGE---------------AEASRMQVSEG----SPEE 1015
            L G+E  KE+  ++     L     E               AE   +  SE       + 
Sbjct: 1664 LRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723

Query: 1016 GSLAKEAFLCKEDV-----EGEEMVTEAEANREDDRKEILPKELDLARERRK-------A 1063
             SL       + DV     E EE++ E+  N E+  K+ +     +A E +K        
Sbjct: 1724 TSLINTKKKLENDVSQLQSEVEEVIQESR-NAEEKAKKAITDAAMMAEELKKEQDTSAHL 1782

Query: 1064 ERPKTSLRKTDSE-REEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            ER K +L +T  + +  +  A  L  +   K+ QKL+A   E E EV  E++  A
Sbjct: 1783 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNA 1837


>gi|7657138 golgi integral membrane protein 4 [Homo sapiens]
          Length = 696

 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 145/717 (20%), Positives = 264/717 (36%), Gaps = 115/717 (16%)

Query: 411  KSRKEKSTEKGEELKKAEGKVRKER--EYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEV 468
            +SR EKS +K    ++ E K  KE    Y +  +  + + +   ++++SA  +       
Sbjct: 68   RSRLEKSLQK----ERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNV------- 116

Query: 469  VTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ 528
                          Q  +   Q   LK ++  D E +  KQGE  +              
Sbjct: 117  --------------QHQMLKSQHEELKKQHS-DLEEEHRKQGEDFSRTFN---------- 151

Query: 529  SPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSH 588
               D K+  L  ++E E    K  +   N+++EN      +L +  QD+ T      + H
Sbjct: 152  ---DHKQKYLQLQQEKEQELSKLKETVYNLREEN-----RQLRKAHQDIHTQLQDVKQQH 203

Query: 589  PYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQE 648
              +  SE E  V   E H      +SA  ++  +++E  K  K  L    SL        
Sbjct: 204  K-NLLSEHEQLVVTLEDH------KSALAAAQTQVAEY-KQLKDTLNRIPSLR------- 248

Query: 649  ITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEES 708
                    KP P ++  +NV +          A    EK  + V    +  D  +  E  
Sbjct: 249  --------KPDPAEQ--QNVTQVAHSPQGYNTAR---EKPTREVQEVSRNNDVWQNHEAV 295

Query: 709  TAQVKDKKAGLPGLEEGGKDSLP--LAYVLALGAPTMNFMVDETAAINSNKESQQLVQKT 766
              + +D K   P  +E    + P  +   +    P  + + +E       +E +Q+ Q  
Sbjct: 296  PGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355

Query: 767  YTLEKKEAMEEDEAPQHRD-------ADIVQGKGEAALWGEAGAV------HEAPLRAWK 813
            +  E+ +   E++  + ++       A++++G   A ++  A  +      +E  L   +
Sbjct: 356  HLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQR 415

Query: 814  PTAEQPELAEEFTEKREIPPGIERGAEGAAEAEG-VRRLGEGGSDPIGQAAAKDAVGLSK 872
               +Q E A++  E +E        A      +G + R  E     + +  A       +
Sbjct: 416  LAVQQVEEAQQLREHQE--------ALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELE 467

Query: 873  DEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGE 932
            +  P+ Q  +      D   ++  QG E   +  E  A   ++ H+  A  +     E  
Sbjct: 468  EGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPR 527

Query: 933  AEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTET 992
             +G        E++  A   +ED  P +D  ++ ED  EEA    EE   +  E  +   
Sbjct: 528  EQGPREADPESEADRAA---VEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSN 584

Query: 993  RLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPK 1052
            +    T   E     V  G+P++          +ED   E+   EAE   ++D  E   +
Sbjct: 585  QKQENT---EVEEHLVMAGNPDQ----------QEDNVDEQYQEEAEEEVQEDLTEEKKR 631

Query: 1053 ELDLARERRKAERPK-TSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETE 1108
            EL+   E    E  + T  +  D E +EV   N  K  +   EE++ + E+G    E
Sbjct: 632  ELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAE 688



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 102/503 (20%), Positives = 180/503 (35%), Gaps = 95/503 (18%)

Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRK 1062
            A++ QV+E    + +L +   L K D   ++ VT+   +         P+  + ARE   
Sbjct: 226  AAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHS---------PQGYNTARE--- 273

Query: 1063 AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKL--KAEEGETETEVRAEEETKAPPN 1120
                     K   E +EV+R N     D ++  + +  +AE+ +       E E +APP 
Sbjct: 274  ---------KPTREVQEVSRNN-----DVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE 319

Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
             +  + E   P E     ++   L E+ +++                         G  E
Sbjct: 320  PIQQEVERREPEEHQVEEEHRKALEEEEMEQV------------------------GQAE 355

Query: 1181 RLSEARD--TEHKDR---EELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAP----- 1230
             L E  D   E +DR   E+   RE   L EGH +    A   P A+P  K Q+P     
Sbjct: 356  HLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR----AEVYPSAKPMIKFQSPYEEQL 411

Query: 1231 EGLIPATGQAEELAAKDHDSCAGLEGRAEG-----------QGGVDVVLRTQEAVAEEDP 1279
            E    A  Q EE         A  + R +G           Q   ++ L+ Q  + E  P
Sbjct: 412  EQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRP 471

Query: 1280 IMAEKFRE----EAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGE-GNTQKNEGMGG 1334
               E+ R+    +A+D D  +  + +     E   +R+++   + EG+ GN  +    G 
Sbjct: 472  QHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGP 531

Query: 1335 GRV--------VAVEVLHGGGETAETAAEEREVLAGSETAEEKTI--ANKASSFSDVAEE 1384
                        AVE ++   +      +E E    +E   E+ +   N+    S+  +E
Sbjct: 532  READPESEADRAAVEDINPADDPNNQGEDEFE---EAEQVREENLPDENEEQKQSNQKQE 588

Query: 1385 ETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGL 1444
             T  ++  ++       +  V+E  +   E    E++T     E                
Sbjct: 589  NTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENT 648

Query: 1445 GQEQEEGSEGQEAATGSGDGRQE 1467
              +  +G E +        GR+E
Sbjct: 649  DDKNNDGEEQEVRDDNRPKGREE 671



 Score = 38.5 bits (88), Expect = 0.050
 Identities = 78/379 (20%), Positives = 144/379 (37%), Gaps = 41/379 (10%)

Query: 947  EEASIDLEDTGPMEDTASKR----EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
            EE  ++ E    +E+   ++    E   EE     EE  +E KE        +   G A 
Sbjct: 331  EEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR 390

Query: 1003 A-----SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
            A     ++  +   SP E  L ++    ++  E +++    EA  +   +  L ++ +  
Sbjct: 391  AEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQ 450

Query: 1058 RE---RRKAERPKTSLRKTDSEREEVTRANA---LKDEDAFK--EEQKLKAEEGETETEV 1109
            ++   R  A + +  L +   + +E  R  A     D D  +  E+Q ++ EEG  E + 
Sbjct: 451  QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDN 510

Query: 1110 RAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLEN 1169
            + ++E +  P       E + P EA   S+      + +  E + P  +     E   E 
Sbjct: 511  QHQDEAEGDPGNRHEPRE-QGPREADPESE-----ADRAAVEDINPADDPNNQGEDEFEE 564

Query: 1170 ITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQA 1229
               +R+E   +   E + +  K  +E +  E   +  G+    E  +     E A + + 
Sbjct: 565  AEQVREENLPDENEEQKQSNQK--QENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEE-EV 621

Query: 1230 PEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAE---KFR 1286
             E L       E+    +H++        E  G  D     +    EE  +  +   K R
Sbjct: 622  QEDLTE-----EKKRELEHNA-------EETYGENDENTDDKNNDGEEQEVRDDNRPKGR 669

Query: 1287 EEAVDEDPEEEEDKECTLE 1305
            EE  +E+ EEEED     E
Sbjct: 670  EEHYEEEEEEEEDGAAVAE 688



 Score = 36.6 bits (83), Expect = 0.19
 Identities = 29/144 (20%), Positives = 62/144 (43%), Gaps = 12/144 (8%)

Query: 488 DDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA-------DVQMNGIPQSPLDDKKDNLDP 540
           DD  N  + E+EE  +V EE   +++ E+ Q+       +V+ + +     D ++DN+D 
Sbjct: 552 DDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDE 611

Query: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV 600
           + + E   +   D  +  K E +  +E    E+ ++    ++          +  D++  
Sbjct: 612 QYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGE-----EQEVRDDNRP 666

Query: 601 GDREAHTDSSTDESARRSSSQELS 624
             RE H +   +E    ++  E S
Sbjct: 667 KGREEHYEEEEEEEEDGAAVAEKS 690


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 153/783 (19%), Positives = 299/783 (38%), Gaps = 97/783 (12%)

Query: 415  EKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEE 474
            E+ TE+ E+ K+A+  + K ++  + K N     +  V  + + QE++   K++   V+E
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQ-TLEKENADLAGELRVLGQ-AKQEVEHKKKKLEAQVQE 1263

Query: 475  MTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ--SPLD 532
            + SK   G+    +  +   K + E      E   G  +  EG+A      +    S L 
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 533  DKKDNLDPEKESE----TSSQKAPDARDNVKDENDGCSES-------------ELEEDKQ 575
            D ++ L  E   +    T  ++  + R++++D+ D   E+             +L + K+
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378

Query: 576  DMKTASST-----------SSRSHPYSSDSEDESAVGDREAHT---------DSSTDESA 615
             ++  +ST                  +   E+++A  D+   T         D   D   
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438

Query: 616  RRSSSQELSENDKPRKSHLPIEESLEIEIEDQ----EITKADVETKPMPIDESFENVL-- 669
            +R     L +  +     L  E+++  +  D+    E    + ETK + +  + E  L  
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498

Query: 670  KEGTEKGTQ----EIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEG 725
            KE  E+  +    E+ + +S K     +  E EK K  L      Q+++ K  L  LE+ 
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL----ETQMEEMKTQLEELEDE 1554

Query: 726  --GKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQH 783
                +   L   + + A    F  D  A    N+E ++ +Q+   L + E   EDE  Q 
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ--LHEYETELEDERKQR 1612

Query: 784  RDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAA 843
              A   + K E       G + +  L+A      + E  ++  + +      +R  E A 
Sbjct: 1613 ALAAAAKKKLE-------GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665

Query: 844  EAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE-KA 902
             +          ++   ++   D + L +D A  ++A     LE ++ A E    L  + 
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725

Query: 903  VLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD-VGESEEEASIDLEDTGPMED 961
             L +E   L       +A L E    E+G  E   A+SD V ++ ++A     +      
Sbjct: 1726 ALQDEKRRLEAR----IAQLEEELEEEQGNME---AMSDRVRKATQQAEQLSNELATERS 1778

Query: 962  TASKREDGSEEAI------------LGGEEPAKERKEVMRTETRLSPFTGEAEAS---RM 1006
            TA K E   ++              + G   +K +  +   E +++    + E     + 
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 1007 QVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
              ++   ++    KE  L  ED        + +A + + R + L ++L+ A E  +++R 
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--ESQRI 1896

Query: 1067 KTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126
              + RK   E +E T +N     +    + KL+     +    R     +   N  GS+ 
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1956

Query: 1127 ENE 1129
            E +
Sbjct: 1957 ETD 1959



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 211/1152 (18%), Positives = 418/1152 (36%), Gaps = 142/1152 (12%)

Query: 406  KPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSA----KFSAQEI 461
            KP L  +R+E      EE++  E +++K +E      NE+KE +   S     K   QE 
Sbjct: 842  KPLLQVTRQE------EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 462  KTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
                 E+    EEM  +    ++ LE+     + +E E   E +E++  +   E  +   
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQ 950

Query: 522  QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNV---KDENDGCSESE--LEEDKQD 576
            QM  + +   +++      + E  T+  K     D +    D+N+  S+    LEE   D
Sbjct: 951  QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010

Query: 577  MKT--ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHL 634
            + T  A       +     ++ ES + + E                +   E D       
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 635  PIEESLEIEIEDQEITKADVETKPM--PIDESF---ENVLKE--GTEKGTQEIAEGLSEK 687
              +   +I     ++ K + E +     +D+      N LK+    E    ++ E L  +
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130

Query: 688  SGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMV 747
                  AE++++D  +  E    +++D        +E          VL           
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190

Query: 748  DETAAINSNKESQQLVQKTYTLE--KKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVH 805
            +        K +Q + + T  LE  K+     D+  Q  + +     GE  + G+A    
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK--Q 1248

Query: 806  EAPLRAWKPTAEQPELAEEFTE----KREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQ 861
            E   +  K  A+  EL  + ++    + E+   + +         G+    EG +  + +
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308

Query: 862  AAA------KDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE-----AAA 910
              A      +D   L ++E  +K  +   + + ++  +  +  L++ + A +      + 
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368

Query: 911  LNLEHLHEVAALREAATS----EEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            LN++       L++ A++    EEG+      + ++ +  EE +   +    +E T ++ 
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK---LEKTKNRL 1425

Query: 967  E----------DGSEEAILGGEEPAKERKEVMRTETRLSP-FTGEAEASRMQVSEGSPEE 1015
            +          D   + +   E+  ++  +++  E  +S  +  E + +  +  E   + 
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485

Query: 1016 GSLAK---EAFLCKEDVEGEEMVTEAE-----ANREDDRKEILPKELDLARERRKAERPK 1067
             SLA+   EA   KE++E    + +AE     ++++D  K +   E        + E  K
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545

Query: 1068 TSLRKTDSEREEVTRAN--------ALKDE--------DAFKEEQKLKAEEGETETEVRA 1111
            T L + + E +    A         ALK +        D   EE++ + +    E E   
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605

Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
            E+E K       +  + E  ++  EL  +  + G +   + +  +      F++ LE+  
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665

Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPE 1231
            A R E         +  +  + + +  +E+ A  E  R+  +        E A  +    
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725

Query: 1232 GLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVD 1291
             L     + E   A+  +     +G  E         R ++A  +     AE+   E   
Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSD-----RVRKATQQ-----AEQLSNELAT 1775

Query: 1292 EDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAE 1351
            E    ++++    + E           +MEG   ++         + A+E        A+
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK-----STIAALE--------AK 1822

Query: 1352 TAAEEREVLAGSETAEEKTIANKASSFSD------VAEEETWHQQDELVGKTAAAGKVVV 1405
             A  E +V    + A EK  A K+    D      + + E   +  E   + A  G   V
Sbjct: 1823 IAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879

Query: 1406 EELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGR 1465
            ++L R  EE   AEE +             A  RK   L +E +E +E  EA      GR
Sbjct: 1880 KQLKRQLEE---AEEESQRI---------NANRRK---LQRELDEATESNEAM-----GR 1919

Query: 1466 QETGAAEKFRLG 1477
            +      K R G
Sbjct: 1920 EVNALKSKLRRG 1931


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 153/783 (19%), Positives = 299/783 (38%), Gaps = 97/783 (12%)

Query: 415  EKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEE 474
            E+ TE+ E+ K+A+  + K ++  + K N     +  V  + + QE++   K++   V+E
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQ-TLEKENADLAGELRVLGQ-AKQEVEHKKKKLEAQVQE 1270

Query: 475  MTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ--SPLD 532
            + SK   G+    +  +   K + E      E   G  +  EG+A      +    S L 
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 533  DKKDNLDPEKESE----TSSQKAPDARDNVKDENDGCSES-------------ELEEDKQ 575
            D ++ L  E   +    T  ++  + R++++D+ D   E+             +L + K+
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385

Query: 576  DMKTASST-----------SSRSHPYSSDSEDESAVGDREAHT---------DSSTDESA 615
             ++  +ST                  +   E+++A  D+   T         D   D   
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445

Query: 616  RRSSSQELSENDKPRKSHLPIEESLEIEIEDQ----EITKADVETKPMPIDESFENVL-- 669
            +R     L +  +     L  E+++  +  D+    E    + ETK + +  + E  L  
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505

Query: 670  KEGTEKGTQ----EIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEG 725
            KE  E+  +    E+ + +S K     +  E EK K  L      Q+++ K  L  LE+ 
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL----ETQMEEMKTQLEELEDE 1561

Query: 726  --GKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQH 783
                +   L   + + A    F  D  A    N+E ++ +Q+   L + E   EDE  Q 
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ--LHEYETELEDERKQR 1619

Query: 784  RDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAA 843
              A   + K E       G + +  L+A      + E  ++  + +      +R  E A 
Sbjct: 1620 ALAAAAKKKLE-------GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672

Query: 844  EAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE-KA 902
             +          ++   ++   D + L +D A  ++A     LE ++ A E    L  + 
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732

Query: 903  VLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD-VGESEEEASIDLEDTGPMED 961
             L +E   L       +A L E    E+G  E   A+SD V ++ ++A     +      
Sbjct: 1733 ALQDEKRRLEAR----IAQLEEELEEEQGNME---AMSDRVRKATQQAEQLSNELATERS 1785

Query: 962  TASKREDGSEEAI------------LGGEEPAKERKEVMRTETRLSPFTGEAEAS---RM 1006
            TA K E   ++              + G   +K +  +   E +++    + E     + 
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 1007 QVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
              ++   ++    KE  L  ED        + +A + + R + L ++L+ A E  +++R 
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--ESQRI 1903

Query: 1067 KTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126
              + RK   E +E T +N     +    + KL+     +    R     +   N  GS+ 
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1963

Query: 1127 ENE 1129
            E +
Sbjct: 1964 ETD 1966



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 211/1152 (18%), Positives = 418/1152 (36%), Gaps = 142/1152 (12%)

Query: 406  KPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSA----KFSAQEI 461
            KP L  +R+E      EE++  E +++K +E      NE+KE +   S     K   QE 
Sbjct: 849  KPLLQVTRQE------EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 462  KTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
                 E+    EEM  +    ++ LE+     + +E E   E +E++  +   E  +   
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQ 957

Query: 522  QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNV---KDENDGCSESE--LEEDKQD 576
            QM  + +   +++      + E  T+  K     D +    D+N+  S+    LEE   D
Sbjct: 958  QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017

Query: 577  MKT--ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHL 634
            + T  A       +     ++ ES + + E                +   E D       
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 635  PIEESLEIEIEDQEITKADVETKPM--PIDESF---ENVLKE--GTEKGTQEIAEGLSEK 687
              +   +I     ++ K + E +     +D+      N LK+    E    ++ E L  +
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137

Query: 688  SGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMV 747
                  AE++++D  +  E    +++D        +E          VL           
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197

Query: 748  DETAAINSNKESQQLVQKTYTLE--KKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVH 805
            +        K +Q + + T  LE  K+     D+  Q  + +     GE  + G+A    
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK--Q 1255

Query: 806  EAPLRAWKPTAEQPELAEEFTE----KREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQ 861
            E   +  K  A+  EL  + ++    + E+   + +         G+    EG +  + +
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315

Query: 862  AAA------KDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE-----AAA 910
              A      +D   L ++E  +K  +   + + ++  +  +  L++ + A +      + 
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375

Query: 911  LNLEHLHEVAALREAATS----EEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            LN++       L++ A++    EEG+      + ++ +  EE +   +    +E T ++ 
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK---LEKTKNRL 1432

Query: 967  E----------DGSEEAILGGEEPAKERKEVMRTETRLSP-FTGEAEASRMQVSEGSPEE 1015
            +          D   + +   E+  ++  +++  E  +S  +  E + +  +  E   + 
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492

Query: 1016 GSLAK---EAFLCKEDVEGEEMVTEAE-----ANREDDRKEILPKELDLARERRKAERPK 1067
             SLA+   EA   KE++E    + +AE     ++++D  K +   E        + E  K
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552

Query: 1068 TSLRKTDSEREEVTRAN--------ALKDE--------DAFKEEQKLKAEEGETETEVRA 1111
            T L + + E +    A         ALK +        D   EE++ + +    E E   
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612

Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
            E+E K       +  + E  ++  EL  +  + G +   + +  +      F++ LE+  
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672

Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPE 1231
            A R E         +  +  + + +  +E+ A  E  R+  +        E A  +    
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732

Query: 1232 GLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVD 1291
             L     + E   A+  +     +G  E         R ++A  +     AE+   E   
Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSD-----RVRKATQQ-----AEQLSNELAT 1782

Query: 1292 EDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAE 1351
            E    ++++    + E           +MEG   ++         + A+E        A+
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK-----STIAALE--------AK 1829

Query: 1352 TAAEEREVLAGSETAEEKTIANKASSFSD------VAEEETWHQQDELVGKTAAAGKVVV 1405
             A  E +V    + A EK  A K+    D      + + E   +  E   + A  G   V
Sbjct: 1830 IAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886

Query: 1406 EELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGR 1465
            ++L R  EE   AEE +             A  RK   L +E +E +E  EA      GR
Sbjct: 1887 KQLKRQLEE---AEEESQRI---------NANRRK---LQRELDEATESNEAM-----GR 1926

Query: 1466 QETGAAEKFRLG 1477
            +      K R G
Sbjct: 1927 EVNALKSKLRRG 1938


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 107/513 (20%), Positives = 198/513 (38%), Gaps = 57/513 (11%)

Query: 455 KFSAQEIKTGLKEVVTAVEEMTSKGKPGQ--EVLEDDQENTLKYEYEEDFEVDEEKQGEK 512
           K  A ++K   K V   +EE   + +  +  E L    E       EE  E  EEK+ E 
Sbjct: 440 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 499

Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
             EE +   + + +  +  + K++  + E+E     ++  D         +G SE E   
Sbjct: 500 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 559

Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
           +K++ +     +       +++E E A    E   +  ++E A +      ++ +KP K+
Sbjct: 560 EKEEGEQEEGET------EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA 613

Query: 633 HLPIEESLEIEIEDQEITKADVETK------PMPIDESFENVLKEG--TEKGTQEIAEG- 683
             P+ +S   E     + K+ VE K        P++E  ++ + +    EKG   +++  
Sbjct: 614 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 673

Query: 684 LSEKSGKHVSAEEKEKDKSKL-------WEESTAQVKD--KKAGLPGLEEGGKDSLPLAY 734
           + EK+   V     E+ KSK         EE   +VK+  K+  +   EE  KD      
Sbjct: 674 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD------ 727

Query: 735 VLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGE 794
                      + ++  A +  KE  + V +  T+ K   +  ++  +     + Q K +
Sbjct: 728 -----------VPEKKKAESPVKE--EAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEK 774

Query: 795 AALWGEAGAVHEAPLRAWKPT-AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGE 853
               GE G+  E   +  K +  E   +  E   K E+    +    G  E +GV   G 
Sbjct: 775 EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNG- 833

Query: 854 GGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNL 913
                +  + A +  G  K E  EK  +  TV   +K  SEG  G  K +  +      +
Sbjct: 834 -----LDLSPADEKKGGDKSE--EKVVVTKTV---EKITSEGGDGATKYITKSVTVTQKV 883

Query: 914 EHLHEVAALREAATSEEGEAEGGVAVSDVGESE 946
           E   E    +  +T +  +      V +V +S+
Sbjct: 884 EEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 916



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 109/475 (22%), Positives = 190/475 (40%), Gaps = 67/475 (14%)

Query: 907  EAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            EA  L ++H      + E    +E ++E   A++ +    EE ++ ++     E+     
Sbjct: 442  EAPKLKVQHKFVEEIIEETKVEDE-KSEMEEALTAI---TEELAVSMK-----EEKKEAA 492

Query: 967  EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCK 1026
            E+  EE     EE A ++  V  T   +    GE E    Q  E   +EG+ + +A    
Sbjct: 493  EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA---- 548

Query: 1027 EDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANAL 1086
                 EE  +E E + E +  E    E +   E  +AE  +   +K + + EEV     L
Sbjct: 549  -----EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE--KKVEEKSEEVATKEEL 601

Query: 1087 KDEDAFKEEQKLKAEEGETETEVRAEEET-KAPPNEMGSDAENEAPVEASELSDNPGLLG 1145
              +   ++ +K K+   ++  E + +    K+P  E G     ++PVE    S  P    
Sbjct: 602  VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 661

Query: 1146 EDSLKETV--VPIFE--ATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSREN 1201
            E+  K  V   P+ E   +P  +  +E   +  + G GE+    ++ E K+ +E    E 
Sbjct: 662  EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ----KEEEEKEVKEAPKEEK 717

Query: 1202 RALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261
               KE   +D       PE +   K ++P          EE  A+       ++   E  
Sbjct: 718  VEKKEEKPKD------VPEKK---KAESP--------VKEEAVAEVVTITKSVKVHLE-- 758

Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQD--RNSEGDGD 1319
                     +E   E  P+  EK +E+A  E   EEE  +   +    +D   N E +G 
Sbjct: 759  ---------KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK 809

Query: 1320 MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANK 1374
             E E  T++    G GR     V+  G +   + A+E++   G + +EEK +  K
Sbjct: 810  EEVEQETKEK---GSGREEEKGVVTNGLDL--SPADEKK---GGDKSEEKVVVTK 856



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 68/333 (20%), Positives = 138/333 (41%), Gaps = 26/333 (7%)

Query: 389 ERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKE- 447
           +  S   + + A+  +   S+ + +KE + EK EE +  E +V  ++  V     E+KE 
Sbjct: 464 DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 523

Query: 448 --NKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVD 505
              K     +   +E   G K           +G   +E  E ++  T      E+ E  
Sbjct: 524 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 583

Query: 506 EEKQGEKSNEE--------GQADVQ-----MNGIPQSPLDDKKDNLDPEKESETSSQKAP 552
           EEK+ E+ +EE          A V+      + +P+SP+++K  +  P+   E    K+P
Sbjct: 584 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG-KSP 642

Query: 553 DARDNVKDENDG-CSESELEEDKQDMKTASSTSSRSH---PYSSDSEDESAVGDREAHTD 608
             +  V+++      +S +EE  +   + S    ++    P S   E +S     +    
Sbjct: 643 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 702

Query: 609 SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENV 668
              ++  + +  +E  E  + +   +P ++  E  ++++ + +    TK + +     ++
Sbjct: 703 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV-----HL 757

Query: 669 LKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDK 701
            KE  E+G     E   EK+G    +EE+  DK
Sbjct: 758 EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 790



 Score = 40.0 bits (92), Expect = 0.017
 Identities = 119/578 (20%), Positives = 216/578 (37%), Gaps = 71/578 (12%)

Query: 1000 EAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANR-EDDRKEILPKELDLAR 1058
            + +AS  Q+ +   +E    +E     E V  E+   + +++  E+D   +  +  + AR
Sbjct: 138  QKQASHAQLGDAYDQE---IRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEAR 194

Query: 1059 ERRKAERPKTSLRKTDSEREEVT-----RANALKDEDAFKEEQKLKAEEGETETEVRAEE 1113
             R   E    +LRK   E   V      +  +L+DE AF      + E  +   +++A  
Sbjct: 195  LRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNH-EEEVADLLAQIQASH 253

Query: 1114 ETKAPPNEMGSDAENEAPVEASEL---SDNPGLLGEDSLKETVVPIFEATPGFEKSL--- 1167
             T    + + +D         S+L   SD      E+  K     + EA    ++++   
Sbjct: 254  ITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSA 313

Query: 1168 -ENITALRKEGGGE--RLSEARDTEHKDREELSSRENR-----ALKEGHRQDGEGALAAP 1219
             E I   R++   +   L   R T+     +LS  E R     +  +   Q  E  L   
Sbjct: 314  KEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGT 373

Query: 1220 EAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGG------------VDVV 1267
            + E A  ++  + L+      +   A       G E R     G            + + 
Sbjct: 374  KWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITIS 433

Query: 1268 LRTQEAVAEEDPIMAE-KFREEAVDEDPEEEEDKEC----TLETE----AMQDRNSEGDG 1318
             + Q+   E   +  + KF EE ++E   E+E  E     T  TE    +M++   E   
Sbjct: 434  SKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAE 493

Query: 1319 DMEGEGNTQKNEGMGGG---RVVAVEVLHGGGETAETAAEEREVL----AGSETAEEKTI 1371
            + E E   ++ E        +  A EV    GE  E   +E E      A S+ AEE   
Sbjct: 494  EKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGS 553

Query: 1372 ANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGV 1431
              + SS  +  E+E    + E  G+ A A +   +++    EEV   EE+      +A V
Sbjct: 554  EKEGSSEKEEGEQEEGETEAEAEGEEAEAKE--EKKVEEKSEEVATKEEL----VADAKV 607

Query: 1432 GTPGALERKTSGLGQE--QEEGSEGQEAATGSGDGR--------QETGAAEKFRLGLSRE 1481
              P   E+  S + +   +E+G      +     G+        +E G +   +  +  +
Sbjct: 608  EKP---EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 664

Query: 1482 GERELSPESLQAMATLPVKPDFTETREKQQHMVQGESE 1519
            G+  +S   ++  A  PV     E  + +  + +GE +
Sbjct: 665  GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 702



 Score = 38.5 bits (88), Expect = 0.050
 Identities = 36/143 (25%), Positives = 57/143 (39%), Gaps = 4/143 (2%)

Query: 1383 EEETWHQQDELVGKT---AAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALER 1439
            E+E    ++ L   T   A + K   +E A   EE P AEE  V    ++ V       +
Sbjct: 463  EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA-AKKSPVKATAPEVK 521

Query: 1440 KTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPV 1499
            +  G  +E+E   E +E   G+   + E G +EK       EGE+E      +A      
Sbjct: 522  EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 581

Query: 1500 KPDFTETREKQQHMVQGESETAD 1522
              +  +  EK + +   E   AD
Sbjct: 582  AKEEKKVEEKSEEVATKEELVAD 604


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 107/513 (20%), Positives = 198/513 (38%), Gaps = 57/513 (11%)

Query: 455 KFSAQEIKTGLKEVVTAVEEMTSKGKPGQ--EVLEDDQENTLKYEYEEDFEVDEEKQGEK 512
           K  A ++K   K V   +EE   + +  +  E L    E       EE  E  EEK+ E 
Sbjct: 64  KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 123

Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
             EE +   + + +  +  + K++  + E+E     ++  D         +G SE E   
Sbjct: 124 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 183

Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
           +K++ +     +       +++E E A    E   +  ++E A +      ++ +KP K+
Sbjct: 184 EKEEGEQEEGET------EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA 237

Query: 633 HLPIEESLEIEIEDQEITKADVETK------PMPIDESFENVLKEG--TEKGTQEIAEG- 683
             P+ +S   E     + K+ VE K        P++E  ++ + +    EKG   +++  
Sbjct: 238 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 297

Query: 684 LSEKSGKHVSAEEKEKDKSKL-------WEESTAQVKD--KKAGLPGLEEGGKDSLPLAY 734
           + EK+   V     E+ KSK         EE   +VK+  K+  +   EE  KD      
Sbjct: 298 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD------ 351

Query: 735 VLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGE 794
                      + ++  A +  KE  + V +  T+ K   +  ++  +     + Q K +
Sbjct: 352 -----------VPEKKKAESPVKE--EAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEK 398

Query: 795 AALWGEAGAVHEAPLRAWKPT-AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGE 853
               GE G+  E   +  K +  E   +  E   K E+    +    G  E +GV   G 
Sbjct: 399 EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNG- 457

Query: 854 GGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNL 913
                +  + A +  G  K E  EK  +  TV   +K  SEG  G  K +  +      +
Sbjct: 458 -----LDLSPADEKKGGDKSE--EKVVVTKTV---EKITSEGGDGATKYITKSVTVTQKV 507

Query: 914 EHLHEVAALREAATSEEGEAEGGVAVSDVGESE 946
           E   E    +  +T +  +      V +V +S+
Sbjct: 508 EEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 540



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 109/475 (22%), Positives = 190/475 (40%), Gaps = 67/475 (14%)

Query: 907  EAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
            EA  L ++H      + E    +E ++E   A++ +    EE ++ ++     E+     
Sbjct: 66   EAPKLKVQHKFVEEIIEETKVEDE-KSEMEEALTAI---TEELAVSMK-----EEKKEAA 116

Query: 967  EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCK 1026
            E+  EE     EE A ++  V  T   +    GE E    Q  E   +EG+ + +A    
Sbjct: 117  EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA---- 172

Query: 1027 EDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANAL 1086
                 EE  +E E + E +  E    E +   E  +AE  +   +K + + EEV     L
Sbjct: 173  -----EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE--KKVEEKSEEVATKEEL 225

Query: 1087 KDEDAFKEEQKLKAEEGETETEVRAEEET-KAPPNEMGSDAENEAPVEASELSDNPGLLG 1145
              +   ++ +K K+   ++  E + +    K+P  E G     ++PVE    S  P    
Sbjct: 226  VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 285

Query: 1146 EDSLKETV--VPIFE--ATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSREN 1201
            E+  K  V   P+ E   +P  +  +E   +  + G GE+    ++ E K+ +E    E 
Sbjct: 286  EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ----KEEEEKEVKEAPKEEK 341

Query: 1202 RALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261
               KE   +D       PE +   K ++P          EE  A+       ++   E  
Sbjct: 342  VEKKEEKPKD------VPEKK---KAESP--------VKEEAVAEVVTITKSVKVHLE-- 382

Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQD--RNSEGDGD 1319
                     +E   E  P+  EK +E+A  E   EEE  +   +    +D   N E +G 
Sbjct: 383  ---------KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK 433

Query: 1320 MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANK 1374
             E E  T++    G GR     V+  G +   + A+E++   G + +EEK +  K
Sbjct: 434  EEVEQETKEK---GSGREEEKGVVTNGLDL--SPADEKK---GGDKSEEKVVVTK 480



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 68/333 (20%), Positives = 138/333 (41%), Gaps = 26/333 (7%)

Query: 389 ERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKE- 447
           +  S   + + A+  +   S+ + +KE + EK EE +  E +V  ++  V     E+KE 
Sbjct: 88  DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 147

Query: 448 --NKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVD 505
              K     +   +E   G K           +G   +E  E ++  T      E+ E  
Sbjct: 148 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 207

Query: 506 EEKQGEKSNEE--------GQADVQ-----MNGIPQSPLDDKKDNLDPEKESETSSQKAP 552
           EEK+ E+ +EE          A V+      + +P+SP+++K  +  P+   E    K+P
Sbjct: 208 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG-KSP 266

Query: 553 DARDNVKDENDG-CSESELEEDKQDMKTASSTSSRSH---PYSSDSEDESAVGDREAHTD 608
             +  V+++      +S +EE  +   + S    ++    P S   E +S     +    
Sbjct: 267 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 326

Query: 609 SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENV 668
              ++  + +  +E  E  + +   +P ++  E  ++++ + +    TK + +     ++
Sbjct: 327 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV-----HL 381

Query: 669 LKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDK 701
            KE  E+G     E   EK+G    +EE+  DK
Sbjct: 382 EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 414



 Score = 38.9 bits (89), Expect = 0.039
 Identities = 60/261 (22%), Positives = 104/261 (39%), Gaps = 34/261 (13%)

Query: 1284 KFREEAVDEDPEEEEDKEC----TLETE----AMQDRNSEGDGDMEGEGNTQKNEGMGGG 1335
            KF EE ++E   E+E  E     T  TE    +M++   E   + E E   ++ E     
Sbjct: 75   KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKK 134

Query: 1336 ---RVVAVEVLHGGGETAETAAEEREVL----AGSETAEEKTIANKASSFSDVAEEETWH 1388
               +  A EV    GE  E   +E E      A S+ AEE     + SS  +  E+E   
Sbjct: 135  SPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGE 194

Query: 1389 QQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQE- 1447
             + E  G+ A A +   +++    EEV   EE+      +A V  P   E+  S + +  
Sbjct: 195  TEAEAEGEEAEAKE--EKKVEEKSEEVATKEEL----VADAKVEKP---EKAKSPVPKSP 245

Query: 1448 -QEEGSEGQEAATGSGDGR--------QETGAAEKFRLGLSREGERELSPESLQAMATLP 1498
             +E+G      +     G+        +E G +   +  +  +G+  +S   ++  A  P
Sbjct: 246  VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSP 305

Query: 1499 VKPDFTETREKQQHMVQGESE 1519
            V     E  + +  + +GE +
Sbjct: 306  VPKSPVEEAKSKAEVGKGEQK 326



 Score = 38.5 bits (88), Expect = 0.050
 Identities = 36/143 (25%), Positives = 57/143 (39%), Gaps = 4/143 (2%)

Query: 1383 EEETWHQQDELVGKT---AAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALER 1439
            E+E    ++ L   T   A + K   +E A   EE P AEE  V    ++ V       +
Sbjct: 87   EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA-AKKSPVKATAPEVK 145

Query: 1440 KTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPV 1499
            +  G  +E+E   E +E   G+   + E G +EK       EGE+E      +A      
Sbjct: 146  EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 205

Query: 1500 KPDFTETREKQQHMVQGESETAD 1522
              +  +  EK + +   E   AD
Sbjct: 206  AKEEKKVEEKSEEVATKEELVAD 228


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
            sapiens]
          Length = 1220

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 138/694 (19%), Positives = 254/694 (36%), Gaps = 122/694 (17%)

Query: 420  KGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKT-----GLKEVVTAVEE 474
            K +E +K++GK +KE++      ++I +    +S +  AQ IK       +K      EE
Sbjct: 33   KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLE--AQGIKADRETVAVKPTENNEEE 90

Query: 475  MTSK-----GKPGQEVLEDDQEN------------TLKYEYEEDFEVDEEKQGEKSNEEG 517
             TSK     G+ G++   DD ++            T K + E     D++    K  ++ 
Sbjct: 91   FTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA 150

Query: 518  QADVQMNGIPQSPLDDKKDNLDPEKESE--TSSQKAPDARDNVKDENDGCSESELEEDKQ 575
            +   Q +       ++ +DN    KE     SS ++ D  D       G  +++  +   
Sbjct: 151  KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGP 210

Query: 576  DMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLP 635
            ++++ +     S    + ++ ++   +RE       +E A+    +E  E +  +K    
Sbjct: 211  NIESGNEDDDASFKIKTVAQKKAEKKERERK--KRDEEKAKLRKLKEKEELETGKKDQSK 268

Query: 636  IEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAE 695
             +ES     E+   +K  V+T  +P  E      K  T    ++  EG           +
Sbjct: 269  QKESQRKFEEETVKSKVTVDTGVIPASEE-----KAETPTAAEDDNEG-----------D 312

Query: 696  EKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINS 755
            +K+KDK K   E   + K+KK G                       T+  M +  A +  
Sbjct: 313  KKKKDKKKKKGEKEEKEKEKKKGP-------------------SKATVKAMQEALAKLKE 353

Query: 756  NKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPT 815
             +E Q+  ++    E+ + +EE EA +  +  + Q K E                  +  
Sbjct: 354  EEERQKREEE----ERIKRLEELEAKRKEEERLEQEKRE------------------RKK 391

Query: 816  AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEA 875
             ++ E  E   ++ ++    +R A   AEA       +G   P            SKD  
Sbjct: 392  QKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVP------------SKDSL 439

Query: 876  PEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEG 935
            P+K+ +       DK   +  Q LE   ++          + E     +  T    E E 
Sbjct: 440  PKKRPIY-----EDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEE 494

Query: 936  GVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLS 995
                 D G  + EA    E+T  +E        G++  I   E P +E +E    E    
Sbjct: 495  EEDTEDAGLDDWEAMASDEETEKVE--------GNKVHIEVKENPEEEEEEEEEEEEDEE 546

Query: 996  PFTGEAEASRMQVSEGSPEEGSLAKEAFLCK--EDVEGEEMVTEAEANREDDRKEILPKE 1053
                E E    + SEG  E+  ++ E    K  +    +EM +++E + +DDR       
Sbjct: 547  SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDR------- 599

Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALK 1087
                +E R  ++ K  + K   E  +      L+
Sbjct: 600  ---TKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 122/562 (21%), Positives = 216/562 (38%), Gaps = 110/562 (19%)

Query: 862  AAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHL----- 916
            AA  +  G +K++ P+K        +  K   + +Q  ++  +  E   L+LE       
Sbjct: 23   AAEIEGAGAAKEQEPQKS-------KGKKKKEKKKQDFDEDDILKELEELSLEAQGIKAD 75

Query: 917  HEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKRE--------- 967
             E  A++    +EE            G+  ++ S D  D+  +ED  SK +         
Sbjct: 76   RETVAVKPTENNEEEFTSKDKKKK--GQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEM 133

Query: 968  -DGSEEAILGGEEPAKERKEVMRTETRLSPFTGEA-------EASRMQVSEGSPEEGSLA 1019
              GS++     + P K + +  ++  +      +        E SR+  S  S +E    
Sbjct: 134  YSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEF 193

Query: 1020 KEAFLCKEDVEGEEMVTEAEANREDDR-----KEILPKELDLA-RERRKAERPKTSLRKT 1073
             ++   ++  +  +     E+  EDD      K +  K+ +   RER+K +  K  LRK 
Sbjct: 194  LQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL 253

Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEV------------RAEEETKAPPNE 1121
              E+EE+      KD+   KE Q+ K EE   +++V            +AE  T A  + 
Sbjct: 254  -KEKEELETGK--KDQSKQKESQR-KFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDN 309

Query: 1122 MGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFE--------------KSL 1167
             G   + +   +  E  +      +   K TV  + EA    +              K L
Sbjct: 310  EGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRL 369

Query: 1168 ENITALRKEGGGERLS----EARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEP 1223
            E + A RKE   ERL     E +  + K+R+E   +E + L +  R+    A A  +   
Sbjct: 370  EELEAKRKEE--ERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427

Query: 1224 AGKVQAPEG----------------LIPATGQAEELAAKDHDSCAGLEGRAEG------- 1260
            A  V+ P                   IP   +++E++ +  + CA +E   +G       
Sbjct: 428  AQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS-ESMELCAAVEVMEQGVPEKEET 486

Query: 1261 ---------QGGVDVVLRTQEAVA---EEDPIMAEKFREEAVDEDPEEEEDKECTLETEA 1308
                     +   D  L   EA+A   E + +   K   E V E+PEEEE++E   E + 
Sbjct: 487  PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIE-VKENPEEEEEEEEEEEEDE 545

Query: 1309 MQDRNSEGDGDMEGEGNTQKNE 1330
              +   E +G+ EG    +++E
Sbjct: 546  ESEEEEEEEGESEGSEGDEEDE 567



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 149/660 (22%), Positives = 239/660 (36%), Gaps = 89/660 (13%)

Query: 473  EEMTSKGKPGQEVLEDD-QENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
            E   SKGK  +E  + D  E+ +  E EE   +  E QG K++ E  A            
Sbjct: 36   EPQKSKGKKKKEKKKQDFDEDDILKELEE---LSLEAQGIKADRETVAV----------- 81

Query: 532  DDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYS 591
                +N + E  S+   +K    +    D+ND    SE  EDK D K+  +   +   YS
Sbjct: 82   -KPTENNEEEFTSKDKKKKGQKGKKQSFDDND----SEELEDK-DSKSKKTAKPKVEMYS 135

Query: 592  SDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITK 651
               +D+      +     +   + +   S+E  +N K  K    I  S E   E  E  +
Sbjct: 136  GSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQ 195

Query: 652  ADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTA- 710
            +    K    ++   N+     E G ++       K+     AE+KE+++ K  EE    
Sbjct: 196  SRKGQKKNQKNKPGPNI-----ESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKL 250

Query: 711  -QVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTL 769
             ++K+K+     LE G KD        +    +     +ET       ++  +       
Sbjct: 251  RKLKEKEE----LETGKKDQ-------SKQKESQRKFEEETVKSKVTVDTGVIPASEEKA 299

Query: 770  EKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA----EEF 825
            E   A E+D     +  D  + KGE     +     + P +A    A Q  LA    EE 
Sbjct: 300  ETPTAAEDDNEGDKKKKDKKKKKGEKE--EKEKEKKKGPSKA-TVKAMQEALAKLKEEEE 356

Query: 826  TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKD---------EAP 876
             +KRE    I+R  E  A+ +   RL +   +   Q   +    L K+         EA 
Sbjct: 357  RQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREAR 416

Query: 877  EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGG 936
             +    L +L+        +  L K     E    + +       L     SE  E    
Sbjct: 417  ARAEATLKLLQAQGVEVPSKDSLPKKRPIYE----DKKRKKIPQQLESKEVSESMELCAA 472

Query: 937  VAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP 996
            V V + G  E+E +    +    EDT     D   EA+   EE  K     +  E + +P
Sbjct: 473  VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD-DWEAMASDEETEKVEGNKVHIEVKENP 531

Query: 997  FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
               E E    +  E S EE           E+ EGE     +E +  D+  E +  E D 
Sbjct: 532  EEEEEEEEEEEEDEESEEE-----------EEEEGE-----SEGSEGDEEDEKVSDEKDS 575

Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETK 1116
             +   K    + S   +DSE +         D+D  KEE+    ++ +   E R  E +K
Sbjct: 576  GKTLDKKPSKEMS---SDSEYDS--------DDDRTKEERAY--DKAKRRIEKRRLEHSK 622



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 130/655 (19%), Positives = 242/655 (36%), Gaps = 93/655 (14%)

Query: 507  EKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVK---DEND 563
            +KQ  KS +  + D+ ++ +       + +     KE E    K    ++  K   DE+D
Sbjct: 3    KKQKNKSEDSTKDDIDLDALAA-----EIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDD 57

Query: 564  GCSE-SELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQE 622
               E  EL  + Q +K    T +     + ++E+E    D++        +S   + S+E
Sbjct: 58   ILKELEELSLEAQGIKADRETVAVKP--TENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115

Query: 623  LSEND-KPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIA 681
            L + D K +K+  P  E      +D +  K   + K                        
Sbjct: 116  LEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAK------------------------ 151

Query: 682  EGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAP 741
             G ++KS K     E+++D SK       ++K++       E G +      ++ +    
Sbjct: 152  -GKAQKSNKKWDGSEEDEDNSK-------KIKERSRINSSGESGDESD---EFLQSRKGQ 200

Query: 742  TMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRD---ADIVQGKGEAALW 798
              N        I S  E      K  T+ +K+A +++   + RD   A + + K +  L 
Sbjct: 201  KKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEEL- 259

Query: 799  GEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDP 858
             E G   ++  +  +   E+  +  + T    + P  E  AE    AE      +   D 
Sbjct: 260  -ETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDK 318

Query: 859  IGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHE 918
              +   K+     K + P K     TV    +A ++ ++  E+     E     LE L  
Sbjct: 319  KKKKGEKEEKEKEKKKGPSKA----TVKAMQEALAKLKEEEERQKREEEERIKRLEELEA 374

Query: 919  VAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAIL--- 975
                 E    E+ E +         + E+E    L+  G +   + +      EA L   
Sbjct: 375  KRKEEERLEQEKRERKK--------QKEKERKERLKKEGKLLTKSQREARARAEATLKLL 426

Query: 976  ---GGEEPAKE---RKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDV 1029
               G E P+K+   +K  +  + +      + E+  +       E   L     + ++ V
Sbjct: 427  QAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS------ESMELCAAVEVMEQGV 480

Query: 1030 -EGEEMVTEAEANREDDRKEILPKELDLA---RERRKAERPKTSLR-KTDSEREEVTRAN 1084
             E EE     E   E+D ++    + +      E  K E  K  +  K + E EE     
Sbjct: 481  PEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE 540

Query: 1085 ALKDEDAFKEEQK---LKAEEGETETEVRAEEET------KAPPNEMGSDAENEA 1130
              +DE++ +EE++    +  EG+ E E  ++E+       K P  EM SD+E ++
Sbjct: 541  EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDS 595



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 82/383 (21%), Positives = 147/383 (38%), Gaps = 30/383 (7%)

Query: 943  GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
            G  +++AS  ++     +    +RE    +     EE AK RK   + E      TG+ +
Sbjct: 215  GNEDDDASFKIKTVAQKKAEKKERERKKRD-----EEKAKLRKLKEKEELE----TGKKD 265

Query: 1003 ASRMQVSEGSPEEGSLAKEAFL----CKEDVEGEEMVTEAEANREDDRKEILPKELDLAR 1058
             S+ + S+   EE ++  +  +         E  E  T AE + E D+K+   K+    +
Sbjct: 266  QSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEK 325

Query: 1059 ERRKAERPKTSLRKT-DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
            E ++ E+ K   + T  + +E + +    ++    +EE+++K  E E E + + EE  + 
Sbjct: 326  EEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLE-ELEAKRKEEERLEQ 384

Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEG 1177
               E     E E      E     G L   S +E       A    E +L+ + A   E 
Sbjct: 385  EKRERKKQKEKER----KERLKKEGKLLTKSQRE-------ARARAEATLKLLQAQGVEV 433

Query: 1178 GGERLSEARDTEHKDREELSSRENRALKE-GHRQDGEGALAAPEAEPAGKVQAPEGLIPA 1236
              +     +   ++D++     +    KE     +   A+   E     K + P  + P 
Sbjct: 434  PSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE 493

Query: 1237 TGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEE 1296
              +  E A  D       +   E   G  V +  +E   EE+    E+  +E  +E+ EE
Sbjct: 494  EEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEE 553

Query: 1297 E---EDKECTLETEAMQDRNSEG 1316
            E   E  E   E E + D    G
Sbjct: 554  EGESEGSEGDEEDEKVSDEKDSG 576



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 68/328 (20%), Positives = 137/328 (41%), Gaps = 32/328 (9%)

Query: 404 DKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKT 463
           ++K   P + ++ +  +G++ KK + K + E+E    K  E K+  +  + K + QE   
Sbjct: 296 EEKAETPTAAEDDN--EGDKKKKDKKKKKGEKE---EKEKEKKKGPSKATVK-AMQEALA 349

Query: 464 GLKEVVTAVEEMTSKGKPGQEV--LEDDQENTLKYEYEEDFEVDEEKQGEKSNEE----- 516
            LKE     EE   K +  + +  LE+ +    + E  E  + + +KQ EK  +E     
Sbjct: 350 KLKE-----EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKE 404

Query: 517 ------GQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL 570
                  Q + +        L   +    P K+S    +K P   D  + +     ES+ 
Sbjct: 405 GKLLTKSQREARARAEATLKLLQAQGVEVPSKDS--LPKKRPIYEDKKRKKIPQQLESKE 462

Query: 571 EEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPR 630
             +  ++  A     +  P   ++       + E   D+  D+    +S +E +E  +  
Sbjct: 463 VSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEE-TEKVEGN 521

Query: 631 KSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGK 690
           K H+ ++E+ E E E++E  + D E++    +E  E    EG+E   ++      + SGK
Sbjct: 522 KVHIEVKENPEEEEEEEEEEEEDEESE----EEEEEEGESEGSEGDEEDEKVSDEKDSGK 577

Query: 691 HVSAE-EKEKDKSKLWEESTAQVKDKKA 717
            +  +  KE      ++    + K+++A
Sbjct: 578 TLDKKPSKEMSSDSEYDSDDDRTKEERA 605



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 48/222 (21%), Positives = 92/222 (41%), Gaps = 52/222 (23%)

Query: 404 DKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVI----------------PKRNEIKE 447
           ++K    K RKE+  ++G+ L K++ + R   E  +                PK+  I E
Sbjct: 388 ERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE 447

Query: 448 NKT--SVSAKFSAQEIKTGLKEVVTAVEEMTS----------------------KGKPGQ 483
           +K    +  +  ++E+   + E+  AVE M                         G    
Sbjct: 448 DKKRKKIPQQLESKEVSESM-ELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDW 506

Query: 484 EVLEDDQE------NTLKYEYEED-FEVDEEKQGEKSNEEGQADVQMNGIPQ-SPLDDKK 535
           E +  D+E      N +  E +E+  E +EE++ E+ +EE + + +  G  + S  D++ 
Sbjct: 507 EAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEED 566

Query: 536 DNLDPEKESETSSQKAPD---ARDNVKDENDGCSESELEEDK 574
           + +  EK+S  +  K P    + D+  D +D  ++ E   DK
Sbjct: 567 EKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDK 608


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.305    0.125    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,370,281
Number of Sequences: 37866
Number of extensions: 3296965
Number of successful extensions: 25301
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 1291
Number of HSP's that attempted gapping in prelim test: 13142
Number of HSP's gapped (non-prelim): 8563
length of query: 1530
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1415
effective length of database: 13,892,928
effective search space: 19658493120
effective search space used: 19658493120
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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