BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|83921609 hypothetical protein LOC127254 [Homo sapiens] (1530 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|83921609 hypothetical protein LOC127254 [Homo sapiens] 3015 0.0 gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 116 1e-25 gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 103 2e-21 gi|150170670 piccolo isoform 2 [Homo sapiens] 87 1e-16 gi|150378539 piccolo isoform 1 [Homo sapiens] 87 1e-16 gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 84 1e-15 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 81 9e-15 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 81 9e-15 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 81 9e-15 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 81 9e-15 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 81 9e-15 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 81 9e-15 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 81 9e-15 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 81 9e-15 gi|156104908 myosin heavy chain 6 [Homo sapiens] 79 4e-14 gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 76 3e-13 gi|87299628 biorientation of chromosomes in cell division 1-like... 74 1e-12 gi|38176300 nestin [Homo sapiens] 73 2e-12 gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 72 4e-12 gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 72 4e-12 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 71 7e-12 gi|148746195 trichohyalin [Homo sapiens] 70 1e-11 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 69 3e-11 gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 69 3e-11 gi|7657138 golgi integral membrane protein 4 [Homo sapiens] 69 3e-11 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 68 6e-11 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 68 6e-11 gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 67 1e-10 gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 67 1e-10 gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 67 1e-10 >gi|83921609 hypothetical protein LOC127254 [Homo sapiens] Length = 1530 Score = 3015 bits (7816), Expect = 0.0 Identities = 1530/1530 (100%), Positives = 1530/1530 (100%) Query: 1 MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRD 60 MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRD Sbjct: 1 MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRD 60 Query: 61 HQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPIL 120 HQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPIL Sbjct: 61 HQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPIL 120 Query: 121 SPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPK 180 SPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPK Sbjct: 121 SPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPK 180 Query: 181 VTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPP 240 VTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPP Sbjct: 181 VTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPP 240 Query: 241 TGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHL 300 TGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHL Sbjct: 241 TGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHL 300 Query: 301 SSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVN 360 SSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVN Sbjct: 301 SSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVN 360 Query: 361 RLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEK 420 RLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEK Sbjct: 361 RLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEK 420 Query: 421 GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGK 480 GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGK Sbjct: 421 GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGK 480 Query: 481 PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDP 540 PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDP Sbjct: 481 PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDP 540 Query: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV 600 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV Sbjct: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV 600 Query: 601 GDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMP 660 GDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMP Sbjct: 601 GDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMP 660 Query: 661 IDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLP 720 IDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLP Sbjct: 661 IDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLP 720 Query: 721 GLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEA 780 GLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEA Sbjct: 721 GLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEA 780 Query: 781 PQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAE 840 PQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAE Sbjct: 781 PQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAE 840 Query: 841 GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900 GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE Sbjct: 841 GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900 Query: 901 KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME 960 KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME Sbjct: 901 KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME 960 Query: 961 DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK 1020 DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK Sbjct: 961 DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK 1020 Query: 1021 EAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEV 1080 EAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEV Sbjct: 1021 EAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEV 1080 Query: 1081 TRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDN 1140 TRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDN Sbjct: 1081 TRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDN 1140 Query: 1141 PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRE 1200 PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRE Sbjct: 1141 PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRE 1200 Query: 1201 NRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEG 1260 NRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEG Sbjct: 1201 NRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEG 1260 Query: 1261 QGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDM 1320 QGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDM Sbjct: 1261 QGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDM 1320 Query: 1321 EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSD 1380 EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSD Sbjct: 1321 EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSD 1380 Query: 1381 VAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERK 1440 VAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERK Sbjct: 1381 VAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERK 1440 Query: 1441 TSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVK 1500 TSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVK Sbjct: 1441 TSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVK 1500 Query: 1501 PDFTETREKQQHMVQGESETADVSPNNMQV 1530 PDFTETREKQQHMVQGESETADVSPNNMQV Sbjct: 1501 PDFTETREKQQHMVQGESETADVSPNNMQV 1530 >gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] Length = 2400 Score = 116 bits (291), Expect = 1e-25 Identities = 262/1182 (22%), Positives = 460/1182 (38%), Gaps = 194/1182 (16%) Query: 415 EKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAK------FSAQEIKT--GLK 466 E E+ E ++A + + E + + +++E K + +E KT GL+ Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332 Query: 467 EVVTAVEEMTSKGKPGQEV----LEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA--- 519 E +EE GQ+ LE+ +E + EE +++E K+G + +G+A Sbjct: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392 Query: 520 DVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKT 579 ++ G+P+ + ++ ++ SE SS PD + + +D+ ++E++ + Sbjct: 1393 GLKEEGLPE------EGSVHGQELSEASS---PDGKGSQEDD-------PVQEEEAGRAS 1436 Query: 580 ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEES 639 AS+ + +E S + + TD S E R+S SQ +KP + + +E Sbjct: 1437 ASAEPCPAEGTEEPTEPPSHLSE----TDPSASE--RQSGSQLEPGLEKPPGATMMGQEH 1490 Query: 640 LEIEIED--QEITKADVETKPMPIDESFENVLKEGTEKG-----TQEIAE-----GLSEK 687 + + E + + + + D + +VL + TEK +AE GL + Sbjct: 1491 TQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDN 1550 Query: 688 SGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPG--LEEGGKDSLPLAYVL--------- 736 A E ++D ++ ++ST + K G G + E +++L +L Sbjct: 1551 DLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRL 1610 Query: 737 ------------ALGAPTMNFMVDETAAINSNKESQQ---------------LVQKTYTL 769 LG ++F +++ A+++ SQ + +K + Sbjct: 1611 RGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPM 1670 Query: 770 EKKEAMEEDEAPQHRDAD---IVQGKGEAALWGEA-----GAVHEAPLRAWKPTAEQPEL 821 K M P D I+Q K GEA G H P + L Sbjct: 1671 SPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGL 1730 Query: 822 AEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQAL 881 ++ PG++ G +G EG +RL +G+A DA+ + E + Sbjct: 1731 GPGLSQ----GPGVDEGEDG----EGSQRLNRDKDPKLGEAEG-DAMAQER-EGKTHNSE 1780 Query: 882 MLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD 941 E +A EGE E+ + + E AA + + AEG A Sbjct: 1781 TSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEA 1840 Query: 942 VGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP----- 996 GE++ E+ E + +G + G +P E E E P Sbjct: 1841 EGEAQPES----------EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDV 1890 Query: 997 FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056 T EAE SEG+ E KEA E VE E TE E E + E E + Sbjct: 1891 ETPEAEWEVQPESEGA-EAPEAEKEAQPETESVEALE--TEGEDEPESEGAEAQEAE-EA 1946 Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETK 1116 A+E +P++ + ++ EE + +D +A + E + + EGE + E E+ + Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPES--EDVEALEVEVETQEAEGEAQPE---SEDVE 2001 Query: 1117 APPNE-MGSDAENEAPVEASELSDNPGLLGEDSLK---ETVVPIFEA--------TPGFE 1164 AP E +AE EA E+ + P GE++ + ET +A P E Sbjct: 2002 APEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE 2061 Query: 1165 KSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALK----EGHRQDGEGALAAPE 1220 + + +E GE E+ D + ++ E + E+ ++ EG Q EG + APE Sbjct: 2062 EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEG-IEAPE 2120 Query: 1221 AEPAGK-----VQAPEGLIPATGQAEELAAKDHDSCA-----GLEGR-AEGQG-----GV 1264 E + ++APE A ++E + A+D + A G+E + AE + GV Sbjct: 2121 TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGV 2180 Query: 1265 DVVLRTQEAVAEEDPIMAEKFREEAVD-----EDPEEEEDKECTLETEAMQDRNSEGDGD 1319 + EA E + I A + EA E PE EE E E E ++ +EG+ Sbjct: 2181 EAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEE--EAQPEPEGVETPEAEGEAQ 2238 Query: 1320 MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREV---------LAGSETAEEK- 1369 E EG TQ G + + +V G G++ E + V G +T ++ Sbjct: 2239 PESEGETQ------GEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRP 2292 Query: 1370 -----TIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVT 1424 +++ASS+ + ++++ + D ++G T + + E + + Sbjct: 2293 GSQTGPSSSRASSWGNCWQKDS--ENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTS 2350 Query: 1425 YTTEAGVG--TPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464 EA +G TP + L ++Q GS A G DG Sbjct: 2351 EQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADG 2392 Score = 86.3 bits (212), Expect = 2e-16 Identities = 236/1049 (22%), Positives = 377/1049 (35%), Gaps = 190/1049 (18%) Query: 609 SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENV 668 ++ ++ A R S ++ + ++ + + ++E +++E E +E T+ + + E + Sbjct: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLE-ETKEGTEGE------GLQEEAVQL 1322 Query: 669 LKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWE----------ESTAQVKDKKAG 718 + TE+G QE EG+ + K E +++++++L E E Q+++ K G Sbjct: 1323 EETKTEEGLQE--EGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG 1380 Query: 719 LPG------LEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKK 772 G LEEG K+ G P E +++ + S+ + Sbjct: 1381 PEGGLQGEALEEGLKEE---------GLP-------EEGSVHGQELSEA------SSPDG 1418 Query: 773 EAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAP--LRAWKPTAEQPELAEEFTEKRE 830 + +ED+ Q +A E E P L P+A + + + E Sbjct: 1419 KGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLE 1478 Query: 831 IPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKD------AVGLSKDEAPEKQALMLT 884 PPG + +A+ + E S + +AA D +V L K E L Sbjct: 1479 KPPGATMMGQEHTQAQPTQGAAERSSS-VACSAALDCDPIWVSVLLKKTEKAFLAHLASA 1537 Query: 885 VLET------------DKAASEGEQGLEKAV--------------------------LAN 906 V E D+ A+E +Q + + + L Sbjct: 1538 VAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTG 1597 Query: 907 EAAALNLEHLHEVAALREAA--------------TSEEGEAEGGVAVSDVGESEE----- 947 E + H + LR + T E+ A S +GE E Sbjct: 1598 ELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFC 1657 Query: 948 --EASIDLEDTGPMEDTASK-------REDGSEEAILG---GEEPAKERKEVMRTETRLS 995 EA + + PM A+ +E + IL GE E EV +T Sbjct: 1658 PCEACVR-KKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTD 1716 Query: 996 PFT-----------GEAEASRMQVSEGSPEEGS--LAKEAFLCKEDVEGEEMVTEAEANR 1042 P + G + V EG EGS L ++ + EG+ M E E Sbjct: 1717 PTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKT 1776 Query: 1043 EDDRKEILPKELDLARERRK--AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKA 1100 + EL A + + +ER +T + + E A A D+D + + Sbjct: 1777 HNSETSA-GSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI 1835 Query: 1101 EEGETETEVRAEEETKAPPNEMGS--DAENEAPVEASELSDNPGLLGEDSLKETVVPIFE 1158 E E E E + E E P G +AE EA E+ ++ + P GE + V E Sbjct: 1836 EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDV-EAPEAEGEAQPESEDVETPE 1894 Query: 1159 ATPGFEKSLENITA--LRKEGGGERLS-EARDTEHKDREELSSRENRALKEGHRQDGEGA 1215 A + E A KE E S EA +TE +D E E + +E Sbjct: 1895 AEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEE--------- 1945 Query: 1216 LAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVA 1275 AA EAE G+ Q PE + + +AEE A + + LE V + TQEA Sbjct: 1946 -AAQEAE--GQTQ-PESEVIESQEAEEEAQPESEDVEALE----------VEVETQEAEG 1991 Query: 1276 EEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGG 1335 E P + EA E E EE+ + + Q + SEG+ E EG TQK EG Sbjct: 1992 EAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK-SEGEEAQEVEGETQKTEGDAQP 2050 Query: 1336 RVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVG 1395 VE E E E +E + E A +A + E + E G Sbjct: 2051 ESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAE--GEAQPESEGVEAPEAEG 2108 Query: 1396 KTAAAGKVVVEELARSGEEVPAAEEMTVTYTT-EAGVGTPGALERKTSGLGQEQEEGSEG 1454 + A + E GE P +E + EA + G + G Q + EG E Sbjct: 2109 EAQKAEGIEAPE--TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEA 2166 Query: 1455 QEAATGSG------DGRQETGAAEKFRLGL-SREGERELSP-----ESLQAMATLPVKPD 1502 QEA + + + G A+ G+ + E E E P E+ +A +P+ Sbjct: 2167 QEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE 2226 Query: 1503 FTETREKQ-QHMVQGESETADVSPNNMQV 1530 ET E + + + E ET + QV Sbjct: 2227 GVETPEAEGEAQPESEGETQGEKKGSPQV 2255 Score = 73.6 bits (179), Expect = 1e-12 Identities = 154/704 (21%), Positives = 253/704 (35%), Gaps = 138/704 (19%) Query: 419 EKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSK 478 +K +L +AEG + +E KT S + E L E E ++ + Sbjct: 1755 DKDPKLGEAEGDAMAQE----------REGKTHNSETSAGSE----LGEAEQEGEGISER 1800 Query: 479 GKPGQEVL--EDDQENTLKYEYEEDFEVDEEKQGEKSNE-EGQADVQMNGIPQSPLDDKK 535 G+ G + ED+ + ++D + +G ++ E EG+A + G+ + Sbjct: 1801 GETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDA 1860 Query: 536 DNLDPEKESETSSQKAPDARDNVKDENDGCS----------ESELEEDKQDMKTASSTSS 585 + E + E+ +AP+A + E++ ESE E + K A + Sbjct: 1861 QEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETE 1920 Query: 586 RSHPYSSDSEDESAVGDREA--------HTDSSTDESARRSSSQELSENDKPRKSHLPIE 637 ++ EDE EA + T + SQE E +P + Sbjct: 1921 SVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV--- 1977 Query: 638 ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697 E+LE+E+E QE E + P E E EG + +E E E G + + Sbjct: 1978 EALEVEVETQE-----AEGEAQPESEDVEAPEAEGEMQEAEE--EAQPESDGVEAQPKSE 2030 Query: 698 EKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNK 757 ++ ++ E+ D + G+E A + + Sbjct: 2031 GEEAQEVEGETQKTEGDAQPESDGVE----------------------------APEAEE 2062 Query: 758 ESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTA- 816 E+Q+ E +EA E + P+ D D + +GEA E EA A K Sbjct: 2063 EAQEAEG-----EVQEA-EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI 2116 Query: 817 EQPELAEEFTEKREIPPGIERGAEGAAEAEGVR-RLGEGGSDPIGQA---------AAKD 866 E PE E + E E E E+EGV + EG + P + A + Sbjct: 2117 EAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPE 2176 Query: 867 AVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE--KAVLANEAAALNLEHLHEVAALRE 924 G+ EA + +E +A E + LE +A A E A E + A E Sbjct: 2177 LEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236 Query: 925 AATSEEGEAEG------GVAVSDVGESEE--EASIDLED--------------------- 955 A EGE +G V++ D G+SEE E+S + + Sbjct: 2237 AQPESEGETQGEKKGSPQVSLGD-GQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQ 2295 Query: 956 TGPMEDTASK-----REDGSEEAILGGEEPAKERK----EVMRTETRLSPFTGEAEASRM 1006 TGP AS ++D + +LG + R TR+ P + +E Sbjct: 2296 TGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEA 2355 Query: 1007 QVSEGSPEEGSLAKEAFLCKED-----VEGEEMVTEAEANREDD 1045 + +PE+G A E + +ED + E V A+ +DD Sbjct: 2356 PLGSRTPEQG--ASEGYDLQEDQALGSLAPTEAVGRADGFGQDD 2397 Score = 63.5 bits (153), Expect = 1e-09 Identities = 174/885 (19%), Positives = 313/885 (35%), Gaps = 132/885 (14%) Query: 399 IAMGLDKKPSLPKSRKEKSTEK--GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKF 456 ++ L+ +P+L + + E+ GEE E VRK+ + PK + + + F Sbjct: 1629 LSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKAT-MGATRGPIKEAF 1687 Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEE 516 Q+I + T E ++ PG+ + T++ + G E+ Sbjct: 1688 DLQQILQRKRGEHTDGE--AAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745 Query: 517 GQADVQMNGIPQSPLDDKK-DNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQ 575 G+ ++N L + + D + E+E +T + + + G E E++ + Sbjct: 1746 GEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSET----------SAGSELGEAEQEGE 1795 Query: 576 DMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLP 635 + T + + + + E+A G D+ +S E E + P Sbjct: 1796 GISERGETGGQGSGHEDNLQGEAAAGG---------DQDPGQSDGAEGIEAPEAEGEAQP 1846 Query: 636 IEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAE 695 E +E + + +A+ E +P D E E AEG ++ + V Sbjct: 1847 ESEGVEAPEAEGDAQEAEGEAQPESEDV-------EAPE------AEGEAQPESEDVETP 1893 Query: 696 EKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINS 755 E E WE Q + + A P E K++ P + A+ + Sbjct: 1894 EAE------WE---VQPESEGAEAP---EAEKEAQP--------------ETESVEALET 1927 Query: 756 NKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPT 815 E + + E +EA +E E ++++++ + A EA +P Sbjct: 1928 EGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE---------AEEEA-----QPE 1973 Query: 816 AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKD-E 874 +E E E E +E AEG A+ E S+D E Sbjct: 1974 SEDVEALEVEVETQE--------AEGEAQPE------------------------SEDVE 2001 Query: 875 APEKQALMLTVLETDKAASEGEQGLEKAV--LANEAAALNLEHLHEVAALREAATSEEGE 932 APE + M E + S+G + K+ A E + + + + E E Sbjct: 2002 APEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE 2061 Query: 933 AEGGVAVSDVGESEEEASIDLEDTGPME--DTASKREDGSEEAILGGEEPAKERKEVMRT 990 E A +V E+E EA + ED E A +G E GE E E T Sbjct: 2062 EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPET 2121 Query: 991 ETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEIL 1050 E P E+E +EG + S EA + + + E EA+ E+ + E+ Sbjct: 2122 EGEAQP---ESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPEL- 2177 Query: 1051 PKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLK--AEEGETETE 1108 + ++ +A+ + ++E E ++ +A +E Q E E E E Sbjct: 2178 -EGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236 Query: 1109 VRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLE 1168 + E E + + GS + ++ E S++ + ED P + S Sbjct: 2237 AQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQT 2296 Query: 1169 NITALRKEGGGERLSEARDTEH-----KDREELSSRENRALKEGHRQDGEGALAAPEAEP 1223 ++ R G + + +H + + S+ A ++ R E + + E P Sbjct: 2297 GPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAP 2356 Query: 1224 AGKVQAPEGLIPATGQAEELAAKDHDSCAGLE--GRAEGQGGVDV 1266 G +G E+ A S A E GRA+G G D+ Sbjct: 2357 LGSRTPEQGASEGYDLQEDQAL---GSLAPTEAVGRADGFGQDDL 2398 >gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo sapiens] Length = 1152 Score = 103 bits (256), Expect = 2e-21 Identities = 154/624 (24%), Positives = 240/624 (38%), Gaps = 76/624 (12%) Query: 877 EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEG- 935 EK + V + K + GE + A+ N+ + + E++ ++E ++ ++G Sbjct: 512 EKSLKLSPVQKQKKQQTIGELTQDTALTENDDS----DEYEEMSEMKEGKACKQHVSQGI 567 Query: 936 ---GVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKE---RKEVMR 989 A + S+EE I E G + SK E+ + EE K RKE + Sbjct: 568 FMTQPATTIEAFSDEEVEIPEEKEGAED---SKGNGIEEQEVEANEENVKVHGGRKE--K 622 Query: 990 TETRLSPFTGEAEASRMQV-SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKE 1048 TE T +AE S + S G E+G + C+E G E + E RE K+ Sbjct: 623 TEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEE--REKGEKD 680 Query: 1049 ILPKELDLARERRKAERPKTSLRKTDSE------REEVTRANALKDEDAFKEEQKLKAEE 1102 E++ E K K +K D E RE+ + ++ + EE+ + EE Sbjct: 681 KGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEE 740 Query: 1103 GETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPG 1162 E + E E+E + G + E E E E E+ +E + G Sbjct: 741 EEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEG----DQGEG 796 Query: 1163 FEKSLENITALRKEGG---GERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAP 1219 E+ E ++EGG G + E + ++ EE E EG ++GEG Sbjct: 797 EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG--EGEEEEGEGE--EE 852 Query: 1220 EAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAE-ED 1278 E E G+ + EG G+ E ++ + E EG+G +E E E+ Sbjct: 853 EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEG------EEEEGEGEGEE 906 Query: 1279 PIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD---MEGEGNTQKNEGMGGG 1335 E EE + EE E+ E E E + +G+G+ EGE ++ EG G G Sbjct: 907 EGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEG 966 Query: 1336 RVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVG 1395 E G GE E EE E G EE+ + + EE ++E G Sbjct: 967 E----EEGEGEGEEGEGEGEEEE---GEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEG 1019 Query: 1396 KTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQE------QE 1449 + G+V EE GEE EE ER+ G G+E +E Sbjct: 1020 EVE--GEVEGEEGEGEGEEEEGEEE---------------GEEREKEGEGEENRRNREEE 1062 Query: 1450 EGSEGQEAATGSGDGRQETGAAEK 1473 E EG+ TG + ++ G K Sbjct: 1063 EEEEGKYQETGEEENERQDGEEYK 1086 Score = 83.2 bits (204), Expect = 2e-15 Identities = 155/637 (24%), Positives = 240/637 (37%), Gaps = 59/637 (9%) Query: 735 VLALGAPTMNFMVDETAAINSNKESQQL--VQKTYTLEKKEAMEEDEA-PQHRDADIVQG 791 V +LG T + ++NSN++S +L VQK + + +D A ++ D+D + Sbjct: 490 VESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEE 549 Query: 792 KGEAALWGEAGAVHEAP-LRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRR 850 E G+A H + + +P ++E E E G E E + V Sbjct: 550 MSEMKE-GKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEA 608 Query: 851 LGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAA 910 E G+ K+ + D+ +K + ++ A +G +G E + Sbjct: 609 NEENVKVHGGR---KEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTC--EEGS 663 Query: 911 LNLEHLHEVAALREAATSEEGEAE---GGVAVSDVGESEEEASIDLEDTGPMEDTASKRE 967 EH + RE ++G E G ++ E EE D E+ E ++ Sbjct: 664 SGAEHWQDEE--REKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQK 721 Query: 968 DGSEEAILGGEEP--AKERKEVMRTETRLSPFTGEAEASRMQVS-EGSPEEGSLAKEAFL 1024 + ++E GGEE E +E R E G+ E +V E EEG KE Sbjct: 722 ERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERA 781 Query: 1025 CKEDV--------EGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSE 1076 KE+ EGEE TE +++ E+ E++ + R+ E + + + E Sbjct: 782 GKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE 841 Query: 1077 REEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASE 1136 EE ++E K E++ + EGE E E E E + E + E E E E Sbjct: 842 GEE-EEGEGEEEEGEGKGEEEGEEGEGEEEGE---EGEGEGEEEEGEGEGEEEGEGEGEE 897 Query: 1137 LSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREEL 1196 GE +E E G K E +EG GE E + E +D E Sbjct: 898 EE------GEGEGEEEGEGEGEEEEGEGKGEEE----GEEGEGEGEEEEGEGEGEDGEG- 946 Query: 1197 SSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEG 1256 E EG ++GEG E E G+ + EG G+ EE + + EG Sbjct: 947 EGEEEEGEWEGEEEEGEG-----EGEEEGEGEGEEG--EGEGEEEEGEGEGEEEEGEEEG 999 Query: 1257 RAEGQG-----GVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQD 1311 EG+G G E E + E EE E+ EE +KE E Sbjct: 1000 EEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENR--- 1056 Query: 1312 RNSEGDGDMEG---EGNTQKNEGMGGGRVVAVEVLHG 1345 RN E + + EG E ++NE G V + G Sbjct: 1057 RNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKG 1093 Score = 80.9 bits (198), Expect = 9e-15 Identities = 168/701 (23%), Positives = 259/701 (36%), Gaps = 130/701 (18%) Query: 491 ENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQK 550 EN EYEE E+ E K ++ +G Q P + D E E + Sbjct: 540 ENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQ-------PATTIEAFSDEEVEIPEEKEG 592 Query: 551 APDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDES--------AVGD 602 A D++ N G E E+E +++++K ++ S D D++ +VG+ Sbjct: 593 AEDSKGN------GIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGE 646 Query: 603 REAHTDSSTDESARRSSS---------QELSENDKPR-KSHLPIEESLEIEIEDQEITKA 652 E + D + SS +E E DK R + P E E+ E +E K Sbjct: 647 AEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELA-EKEEWKKR 705 Query: 653 DVETKPMPIDESFENVLKEGTEKG-TQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQ 711 D E E + ++G +K QE+ EG E+ G+ EE+E D+ + Sbjct: 706 DGE-------EQEQKEREQGHQKERNQEMEEGGEEEHGE---GEEEEGDREE-------- 747 Query: 712 VKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEK 771 +++K G G EEG E + +E ++ +K Sbjct: 748 -EEEKEG-EGKEEG-----------------------EGEEVEGEREKEEGERKKEERAG 782 Query: 772 KEAMEEDEAPQHR-DADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKRE 830 KE E+E Q + + +G+GE E G V + K E+ E EE + E Sbjct: 783 KEEKGEEEGDQGEGEEEETEGRGEEK--EEGGEVEGGEVEEGKGEREEEE--EEGEGEEE 838 Query: 831 IPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDK 890 G E EG E EG + E G + G+ ++ G ++E E + E ++ Sbjct: 839 EGEGEEEEGEGEEE-EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEE 897 Query: 891 AASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD-VGESEEEA 949 EGE G E+ E EEGE +G + GE EEE Sbjct: 898 EEGEGE-GEEEGEGEGE--------------------EEEGEGKGEEEGEEGEGEGEEEE 936 Query: 950 SIDLEDTGPMEDTASKRE----------DGSEEAILGGEEPAKERKEVM---RTETRLSP 996 + G E + E +G EE GEE E +E E Sbjct: 937 GEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE 996 Query: 997 FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056 GE E + EG EE +E + +VEGEE E E ++ E KE + Sbjct: 997 EEGEEEGEGEEEGEGEGEE----EEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052 Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETK 1116 RR E + K EE N +D + +K+ K+K G + + K Sbjct: 1053 EENRRNREEEEEEEGKYQETGEE---ENERQDGEEYKKVSKIK---GSVKYGKHKTYQKK 1106 Query: 1117 APPNEMGSDAE--NEAPVEASELSDNPGLLGEDSLKETVVP 1155 + N G+ E ++ PV++ L N G G V+P Sbjct: 1107 SVTNTQGNGKEQRSKMPVQSKRLLKN-GPSGSKKFWNNVLP 1146 Score = 78.2 bits (191), Expect = 6e-14 Identities = 118/477 (24%), Positives = 182/477 (38%), Gaps = 96/477 (20%) Query: 1014 EEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT 1073 EE S KE CK+ V +T+ E E E+++ E+ AE K Sbjct: 548 EEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDE----EVEIPEEKEGAEDSK------ 597 Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETE-TEVRAEEET-KAPPNEMGSDAENEAP 1131 N +++++ E+ +K G E TE+ +++ T KA +E + + EA Sbjct: 598 ---------GNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEA- 647 Query: 1132 VEASELSDNPGLLGEDSLKETVVPIFEATPGFE--KSLENITALRKEGGGERLSEAR-DT 1188 D P G+ + +E + G E + E + +G GE + Sbjct: 648 ------EDGPEGRGDGTCEE-------GSSGAEHWQDEEREKGEKDKGRGEMERPGEGEK 694 Query: 1189 EHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDH 1248 E ++EE R+ ++ R+ G E E G+ + EG + EE ++ Sbjct: 695 ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEG------EEEEGDREEE 748 Query: 1249 DSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEA 1308 + G EG+ EG+G EE E E+E+ E E A Sbjct: 749 EEKEG-EGKEEGEG------------------------EEV--EGEREKEEGERKKEERA 781 Query: 1309 MQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEE 1368 ++ E +GD +GEG ++ EG G + EV GGE E E E E EE Sbjct: 782 GKEEKGEEEGD-QGEGEEEETEGRGEEKEEGGEV--EGGEVEEGKGEREEEEEEGEGEEE 838 Query: 1369 KTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTE 1428 + + EEE +++E GK EE GE EE E Sbjct: 839 E---------GEGEEEEGEGEEEEGEGKG--------EEEGEEGEGEEEGEEGEGEGEEE 881 Query: 1429 AGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERE 1485 G G E + G G+ +EE EG+ G G+G +E G + G EGE E Sbjct: 882 EGEG-----EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGE 933 Score = 72.8 bits (177), Expect = 2e-12 Identities = 132/636 (20%), Positives = 222/636 (34%), Gaps = 138/636 (21%) Query: 404 DKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKT 463 D++ +P+ ++ KG +++ E + +E V R E KT + + + T Sbjct: 581 DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKE----KTEILS-----DDLT 631 Query: 464 GLKEVVTAVEEMTSKGKPGQEVLEDD--QENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521 EV + + + G E D +E + E+ +D +E ++GEK ++G+ ++ Sbjct: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQD---EEREKGEK--DKGRGEM 686 Query: 522 QMNGIPQSPLDDKKD--NLDPEKESETSSQKAPDARDNVKDENDGCSE-SELEEDKQDMK 578 + G + L +K++ D E++ + ++ N + E G E E EE++ D + Sbjct: 687 ERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDRE 746 Query: 579 TASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEE 638 + E E G+RE E + E D+ E Sbjct: 747 EEEEKEGEG---KEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEG 803 Query: 639 SLEIEIEDQEITKADVET-KPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697 E + E E+ +VE K +E E +E +G +E EG E+ E + Sbjct: 804 RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE 863 Query: 698 EKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNK 757 E + + EE + ++++ G EEG + Sbjct: 864 EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEG---------------------------- 895 Query: 758 ESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAE 817 E++E E E + + +G+G+ GE G Sbjct: 896 ------------EEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE------------ 931 Query: 818 QPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPE 877 EE + E G G E E EG GEG + G+ ++ G ++E E Sbjct: 932 ----GEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE 987 Query: 878 KQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGV 937 + E ++ EGE+ E EEGE E Sbjct: 988 GEG------EEEEGEEEGEE--------------------------EGEGEEEGEGE--- 1012 Query: 938 AVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPF 997 GE EEE ++ E G + + E+G EE GEE KE Sbjct: 1013 -----GEEEEEGEVEGEVEGEEGEGEGEEEEGEEE----GEEREKE-------------- 1049 Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEE 1033 GE E +R E EEG + E +GEE Sbjct: 1050 -GEGEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084 Score = 35.4 bits (80), Expect = 0.43 Identities = 35/165 (21%), Positives = 69/165 (41%), Gaps = 21/165 (12%) Query: 473 EEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLD 532 EE +G+ +E E++ E + E E + E +EE++GE E + + G + + Sbjct: 982 EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEE---E 1038 Query: 533 DKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSS 592 +++ + EKE E +EN E E EE+ + +T + R Sbjct: 1039 GEEEGEEREKEGE-------------GEENRRNREEEEEEEGKYQETGEEENER-----Q 1080 Query: 593 DSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIE 637 D E+ V + ++ ++ S N K ++S +P++ Sbjct: 1081 DGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQ 1125 Score = 33.1 bits (74), Expect = 2.1 Identities = 56/250 (22%), Positives = 93/250 (37%), Gaps = 31/250 (12%) Query: 1280 IMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVA 1339 IM+ E+++ P +++ K+ T+ +E D E E ++ EG + V+ Sbjct: 505 IMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVS 564 Query: 1340 VEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAA 1399 + T A + EV E EEK A + S + + E+E ++ + K Sbjct: 565 QGIFMTQPATTIEAFSDEEV----EIPEEKEGA-EDSKGNGIEEQEVEANEENV--KVHG 617 Query: 1400 AGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGT----PGALERKTSGLGQEQEEGSEGQ 1455 K E L+ + E EA G G E +SG Q+E E Sbjct: 618 GRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKG 677 Query: 1456 EAATG------SGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTETREK 1509 E G G+G +E E+++ R+GE + E Q +E+ Sbjct: 678 EKDKGRGEMERPGEGEKELAEKEEWK---KRDGEEQEQKEREQG-----------HQKER 723 Query: 1510 QQHMVQGESE 1519 Q M +G E Sbjct: 724 NQEMEEGGEE 733 >gi|150170670 piccolo isoform 2 [Homo sapiens] Length = 4935 Score = 87.0 bits (214), Expect = 1e-16 Identities = 170/833 (20%), Positives = 323/833 (38%), Gaps = 123/833 (14%) Query: 405 KKPSLPKSRKEKSTEK-----GEELKKAEGKVRKEREYVIPKRNEIKENKTSV--SAKFS 457 +K L K ++ S EK + K+ E K+ K++ + ++ + E K + K Sbjct: 1169 EKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIR 1228 Query: 458 AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517 ++E K L+E E+ + E+ + + LK + + E E + K+ +EG Sbjct: 1229 SEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEG 1288 Query: 518 -QADVQMNGIP----------------------QSPLDDKKDNLDPEKE--------SET 546 Q +M G+P Q P K D ++P KE S+T Sbjct: 1289 KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDT 1348 Query: 547 SSQKAPDARDNVKD---ENDGCSESELE-------EDKQDMK-----TASSTSSRSHPYS 591 SS + P + + D +DG S S E ++K +K + S SS S P Sbjct: 1349 SSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSD 1408 Query: 592 SDSEDESAVGDREAHTDSSTDE-SARRSSSQELS-ENDKPRKSHLPIEESLEIEIEDQEI 649 + + + EA + DE S +++ E+S E K ++ + E+LEI I ++EI Sbjct: 1409 LAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEI 1468 Query: 650 TKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEE----------KEK 699 ++ E K +S +++ K E + ++ + + S EE + K Sbjct: 1469 KESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRK 1528 Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEG--GKDSLPL-AYVLALGAPTMNFMVDETAAINSN 756 ++ + S+ + K + + G EE K + + A A G+ F+ ++ I+S+ Sbjct: 1529 RRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSS 1588 Query: 757 KESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTA 816 ESQ+ E+ + + A +HR + K ++ +AG H + Sbjct: 1589 TESQK-------KEETKGKGKITAGKHRR---LTRKSSTSIDEDAGRRHSWHDEDDEAFD 1638 Query: 817 EQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP 876 E PEL T+ +E + G G + + L +D +++ L DE P Sbjct: 1639 ESPELKYRETKSQESEELVVTGGGGLRRFKTI-ELNSTIADKYSAESSQKKTSLYFDEEP 1697 Query: 877 EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGG 936 E + LT D++ EG L + + + V++L E + S + Sbjct: 1698 ELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTS------VSSLDEDSDSSPSHKK-- 1749 Query: 937 VAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP 996 GES+++ GP+ T ED SE EE +E +E+++ + + Sbjct: 1750 ------GESKQQRKARHRPHGPLLPTI---EDSSE------EEELREEEELLKEQEKQRE 1794 Query: 997 FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056 + S + S+ +E + K + +A E L + ++ Sbjct: 1795 IEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEE------LRQAAEM 1848 Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFK-----------EEQKLKAEEGET 1105 R + + ++D E E++ ++ + +K +EQ + +EG Sbjct: 1849 EELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQ 1908 Query: 1106 ETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNP----GLLGEDSLKETVV 1154 + AEE + ++ A E E+ + G+L ED + E++V Sbjct: 1909 KALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLV 1961 Score = 62.0 bits (149), Expect = 4e-09 Identities = 159/817 (19%), Positives = 312/817 (38%), Gaps = 124/817 (15%) Query: 429 GKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKP-GQEVLE 487 G +RK + P + K + V + S+Q KT + V V++ + K ++V+ Sbjct: 1120 GDIRK----MPPAPSGPKASPMPVPTESSSQ--KTAVPPQVKLVKKQEQEVKTEAEKVIL 1173 Query: 488 DDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETS 547 + + TL E ++KQ E E+ +A + PL ++K L PE+E S Sbjct: 1174 EKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQE---KKPLPEEK-KLIPEEEKIRS 1229 Query: 548 SQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHT 607 +K P + + EDK+ + A +++ + ++ Sbjct: 1230 EEKKPLLEE----------KKPTPEDKKLLPEAKTSAPEEQKHDL----------LKSQV 1269 Query: 608 DSSTDESARRSSSQELSENDKP--RKSHLPIEESLEIEIEDQEITKADVETKPMPIDESF 665 + ++ R + + + E +P + LP + ED + TK ++ +P P + Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKT-IKEQPQPPCTAK 1328 Query: 666 ENVLKEGTEKGTQE-----IAEGLSEKSGKHVSAEEKEKD--KSKLWEESTAQVKDKKAG 718 + ++ G EK +E + KS + +S D S L E + D+K Sbjct: 1329 PDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDI 1388 Query: 719 LPGLEEGG--KDSLPLAYV-LALGAPTMNFMVDETAAINSNKESQQLVQ-------KTYT 768 L GL++ ++S P + LA T+ +++ A+ ++++S++ Q + Sbjct: 1389 LKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKD 1448 Query: 769 LEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEK 828 EK +++ E + +I + + E + + + P + K E+ E ++ T + Sbjct: 1449 QEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIP--SSKDHKEKSEFVDDITTR 1506 Query: 829 REIPPGIERGAEGAAEAEGVRR----LGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLT 884 RE +E +E R+ +G SD Q +D+ G ++E ++ ++ Sbjct: 1507 REPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQ---EDSQGSGEEEDFIRKQIIEM 1563 Query: 885 VLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGE 944 + D + SE ++ + L E+++ E+ EE + +G + Sbjct: 1564 SADEDASGSEDDEFIRN-------------QLKEISSSTESQKKEETKGKGKITAGKHRR 1610 Query: 945 SEEEASIDLE-----------------DTGPMEDTASKREDGSEEAILGGEEPAKERKEV 987 ++S ++ D P + SEE ++ G + K + Sbjct: 1611 LTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTI 1670 Query: 988 MRTETRLSPFTGEAEASR------------MQVSEGSPEEGSLAK-EAFLCKEDVEGEEM 1034 T ++ E+ + M+ SPE+ S + + L Sbjct: 1671 ELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTS 1730 Query: 1035 VTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT--DSEREEVTRANALKDEDAF 1092 T + ED K+ + ++R+ RP L T DS EE R ++E+ Sbjct: 1731 PTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELR----EEEELL 1786 Query: 1093 KEEQKLKAEEGET-----------ETEVRAE---EETKAPPNEMGSDAENEAPVEASELS 1138 KE++K + E + + E+RA+ E K PP+ + S E+ +P E + Sbjct: 1787 KEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNL-SPIEDASPTEELRQA 1845 Query: 1139 DNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRK 1175 L S E I GFE S E I ++K Sbjct: 1846 AEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQK 1882 Score = 35.0 bits (79), Expect = 0.56 Identities = 92/551 (16%), Positives = 198/551 (35%), Gaps = 89/551 (16%) Query: 873 DEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGE 932 + + +K A+ V K E + EK +L L++E + + + + E Sbjct: 1142 ESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLE 1201 Query: 933 AEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTET 992 + A+ + EE + E+ K ++ +L ++P E K+++ Sbjct: 1202 KDKASALQEKKPLPEEKKLIPEE--------EKIRSEEKKPLLEEKKPTPEDKKLLPEAK 1253 Query: 993 RLSPFTGEAEASRMQVSEGSPE-EGSLA----KEAFLCKEDVEGEEMVTEAEANREDDRK 1047 +P + + + QV + EG +A +E + +EG T +EDD+ Sbjct: 1254 TSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKT 1313 Query: 1048 EILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDE------DAFKEEQKLKAE 1101 KE K ++ + KT+ E ++ +++ + + D + + Sbjct: 1314 TKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS 1373 Query: 1102 EGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSD-----------NPGLLGEDSLK 1150 GE + + +E+ + S ++ +P S+L+ L ++ + Sbjct: 1374 LGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSE 1433 Query: 1151 ETVVPIFEATPGFEKSLENITALRKEG----GGERLSEARDTEHKDREELSSRENRALKE 1206 + P E +P K E +L + E + E+++ E KD + S+++ + Sbjct: 1434 KKTQP-HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE-ERKDTFKKDSQQDIPSSK 1491 Query: 1207 GHRQDGEGAL-AAPEAEPAGKVQ----APEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261 H++ E EP V+ + +P + + + D + + G Sbjct: 1492 DHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSG- 1550 Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDME 1321 EE+ + ++ E + DED ED E ++++ E E Sbjct: 1551 --------------EEEDFIRKQIIEMSADEDASGSED------DEFIRNQLKEISSSTE 1590 Query: 1322 GEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDV 1381 + +K E G G++ TA + R + S T+ ++ D Sbjct: 1591 SQ---KKEETKGKGKI--------------TAGKHRRLTRKSSTSIDE----------DA 1623 Query: 1382 AEEETWHQQDE 1392 +WH +D+ Sbjct: 1624 GRRHSWHDEDD 1634 >gi|150378539 piccolo isoform 1 [Homo sapiens] Length = 5142 Score = 87.0 bits (214), Expect = 1e-16 Identities = 170/833 (20%), Positives = 323/833 (38%), Gaps = 123/833 (14%) Query: 405 KKPSLPKSRKEKSTEK-----GEELKKAEGKVRKEREYVIPKRNEIKENKTSV--SAKFS 457 +K L K ++ S EK + K+ E K+ K++ + ++ + E K + K Sbjct: 1169 EKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIR 1228 Query: 458 AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517 ++E K L+E E+ + E+ + + LK + + E E + K+ +EG Sbjct: 1229 SEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEG 1288 Query: 518 -QADVQMNGIP----------------------QSPLDDKKDNLDPEKE--------SET 546 Q +M G+P Q P K D ++P KE S+T Sbjct: 1289 KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDT 1348 Query: 547 SSQKAPDARDNVKD---ENDGCSESELE-------EDKQDMK-----TASSTSSRSHPYS 591 SS + P + + D +DG S S E ++K +K + S SS S P Sbjct: 1349 SSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSD 1408 Query: 592 SDSEDESAVGDREAHTDSSTDE-SARRSSSQELS-ENDKPRKSHLPIEESLEIEIEDQEI 649 + + + EA + DE S +++ E+S E K ++ + E+LEI I ++EI Sbjct: 1409 LAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEI 1468 Query: 650 TKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEE----------KEK 699 ++ E K +S +++ K E + ++ + + S EE + K Sbjct: 1469 KESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRK 1528 Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEG--GKDSLPL-AYVLALGAPTMNFMVDETAAINSN 756 ++ + S+ + K + + G EE K + + A A G+ F+ ++ I+S+ Sbjct: 1529 RRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSS 1588 Query: 757 KESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTA 816 ESQ+ E+ + + A +HR + K ++ +AG H + Sbjct: 1589 TESQK-------KEETKGKGKITAGKHRR---LTRKSSTSIDEDAGRRHSWHDEDDEAFD 1638 Query: 817 EQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP 876 E PEL T+ +E + G G + + L +D +++ L DE P Sbjct: 1639 ESPELKYRETKSQESEELVVTGGGGLRRFKTI-ELNSTIADKYSAESSQKKTSLYFDEEP 1697 Query: 877 EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGG 936 E + LT D++ EG L + + + V++L E + S + Sbjct: 1698 ELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTS------VSSLDEDSDSSPSHKK-- 1749 Query: 937 VAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP 996 GES+++ GP+ T ED SE EE +E +E+++ + + Sbjct: 1750 ------GESKQQRKARHRPHGPLLPTI---EDSSE------EEELREEEELLKEQEKQRE 1794 Query: 997 FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056 + S + S+ +E + K + +A E L + ++ Sbjct: 1795 IEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEE------LRQAAEM 1848 Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFK-----------EEQKLKAEEGET 1105 R + + ++D E E++ ++ + +K +EQ + +EG Sbjct: 1849 EELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQ 1908 Query: 1106 ETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNP----GLLGEDSLKETVV 1154 + AEE + ++ A E E+ + G+L ED + E++V Sbjct: 1909 KALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLV 1961 Score = 62.0 bits (149), Expect = 4e-09 Identities = 159/817 (19%), Positives = 312/817 (38%), Gaps = 124/817 (15%) Query: 429 GKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKP-GQEVLE 487 G +RK + P + K + V + S+Q KT + V V++ + K ++V+ Sbjct: 1120 GDIRK----MPPAPSGPKASPMPVPTESSSQ--KTAVPPQVKLVKKQEQEVKTEAEKVIL 1173 Query: 488 DDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETS 547 + + TL E ++KQ E E+ +A + PL ++K L PE+E S Sbjct: 1174 EKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQE---KKPLPEEK-KLIPEEEKIRS 1229 Query: 548 SQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHT 607 +K P + + EDK+ + A +++ + ++ Sbjct: 1230 EEKKPLLEE----------KKPTPEDKKLLPEAKTSAPEEQKHDL----------LKSQV 1269 Query: 608 DSSTDESARRSSSQELSENDKP--RKSHLPIEESLEIEIEDQEITKADVETKPMPIDESF 665 + ++ R + + + E +P + LP + ED + TK ++ +P P + Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKT-IKEQPQPPCTAK 1328 Query: 666 ENVLKEGTEKGTQE-----IAEGLSEKSGKHVSAEEKEKD--KSKLWEESTAQVKDKKAG 718 + ++ G EK +E + KS + +S D S L E + D+K Sbjct: 1329 PDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDI 1388 Query: 719 LPGLEEGG--KDSLPLAYV-LALGAPTMNFMVDETAAINSNKESQQLVQ-------KTYT 768 L GL++ ++S P + LA T+ +++ A+ ++++S++ Q + Sbjct: 1389 LKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKD 1448 Query: 769 LEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEK 828 EK +++ E + +I + + E + + + P + K E+ E ++ T + Sbjct: 1449 QEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIP--SSKDHKEKSEFVDDITTR 1506 Query: 829 REIPPGIERGAEGAAEAEGVRR----LGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLT 884 RE +E +E R+ +G SD Q +D+ G ++E ++ ++ Sbjct: 1507 REPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQ---EDSQGSGEEEDFIRKQIIEM 1563 Query: 885 VLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGE 944 + D + SE ++ + L E+++ E+ EE + +G + Sbjct: 1564 SADEDASGSEDDEFIRN-------------QLKEISSSTESQKKEETKGKGKITAGKHRR 1610 Query: 945 SEEEASIDLE-----------------DTGPMEDTASKREDGSEEAILGGEEPAKERKEV 987 ++S ++ D P + SEE ++ G + K + Sbjct: 1611 LTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTI 1670 Query: 988 MRTETRLSPFTGEAEASR------------MQVSEGSPEEGSLAK-EAFLCKEDVEGEEM 1034 T ++ E+ + M+ SPE+ S + + L Sbjct: 1671 ELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTS 1730 Query: 1035 VTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT--DSEREEVTRANALKDEDAF 1092 T + ED K+ + ++R+ RP L T DS EE R ++E+ Sbjct: 1731 PTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELR----EEEELL 1786 Query: 1093 KEEQKLKAEEGET-----------ETEVRAE---EETKAPPNEMGSDAENEAPVEASELS 1138 KE++K + E + + E+RA+ E K PP+ + S E+ +P E + Sbjct: 1787 KEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNL-SPIEDASPTEELRQA 1845 Query: 1139 DNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRK 1175 L S E I GFE S E I ++K Sbjct: 1846 AEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQK 1882 Score = 35.0 bits (79), Expect = 0.56 Identities = 92/551 (16%), Positives = 198/551 (35%), Gaps = 89/551 (16%) Query: 873 DEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGE 932 + + +K A+ V K E + EK +L L++E + + + + E Sbjct: 1142 ESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLE 1201 Query: 933 AEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTET 992 + A+ + EE + E+ K ++ +L ++P E K+++ Sbjct: 1202 KDKASALQEKKPLPEEKKLIPEE--------EKIRSEEKKPLLEEKKPTPEDKKLLPEAK 1253 Query: 993 RLSPFTGEAEASRMQVSEGSPE-EGSLA----KEAFLCKEDVEGEEMVTEAEANREDDRK 1047 +P + + + QV + EG +A +E + +EG T +EDD+ Sbjct: 1254 TSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKT 1313 Query: 1048 EILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDE------DAFKEEQKLKAE 1101 KE K ++ + KT+ E ++ +++ + + D + + Sbjct: 1314 TKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS 1373 Query: 1102 EGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSD-----------NPGLLGEDSLK 1150 GE + + +E+ + S ++ +P S+L+ L ++ + Sbjct: 1374 LGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSE 1433 Query: 1151 ETVVPIFEATPGFEKSLENITALRKEG----GGERLSEARDTEHKDREELSSRENRALKE 1206 + P E +P K E +L + E + E+++ E KD + S+++ + Sbjct: 1434 KKTQP-HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE-ERKDTFKKDSQQDIPSSK 1491 Query: 1207 GHRQDGEGAL-AAPEAEPAGKVQ----APEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261 H++ E EP V+ + +P + + + D + + G Sbjct: 1492 DHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSG- 1550 Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDME 1321 EE+ + ++ E + DED ED E ++++ E E Sbjct: 1551 --------------EEEDFIRKQIIEMSADEDASGSED------DEFIRNQLKEISSSTE 1590 Query: 1322 GEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDV 1381 + +K E G G++ TA + R + S T+ ++ D Sbjct: 1591 SQ---KKEETKGKGKI--------------TAGKHRRLTRKSSTSIDE----------DA 1623 Query: 1382 AEEETWHQQDE 1392 +WH +D+ Sbjct: 1624 GRRHSWHDEDD 1634 >gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] Length = 2454 Score = 83.6 bits (205), Expect = 1e-15 Identities = 151/748 (20%), Positives = 281/748 (37%), Gaps = 130/748 (17%) Query: 419 EKGEELKKAEGKVRKEREYV-----IPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVE 473 ++ E AEG V K+ + +PK+ + + V ++ T L+ A Sbjct: 845 QERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAET 904 Query: 474 EMTSKG------KPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIP 527 + SK K Q+ L D E LK + ++ D++KQ +K EE Sbjct: 905 KEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEE----------K 954 Query: 528 QSPLDDKKDNLDPEKESETSS---QKAPDARD------NVKDENDGCSESELEEDKQDMK 578 + P D KK + E++ E+SS +K P+ + +K +G ++ E K+ K Sbjct: 955 KKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE----KKSKK 1010 Query: 579 TASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESA------RRSSSQELSENDKPRKS 632 TS + S +E + GD DSS D+ + R +L ++ Sbjct: 1011 IRDKTSKKKDELSDYAEKSTGKGDS---CDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQ 1067 Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHV 692 ++ + +++ +D K + + E N+ +++ T+EI G S + Sbjct: 1068 DCSSSDTEKYSMKEDGCNSSDKRLKRIELRER-RNL---SSKRNTKEIQSGSSSSDAEES 1123 Query: 693 SAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAA 752 S + K+K + ++ VK+KK +L T D T++ Sbjct: 1124 SEDNKKKKQRTSSKKKAVIVKEKKRN------------------SLRTSTKRKQADITSS 1165 Query: 753 INSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAW 812 +S+ E + + ++ E + + + + + ++ G + + L Sbjct: 1166 SSSDIED----------DDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1215 Query: 813 KPTAEQPELAEEFTEKR--------EIPPGIERGAEGAAE---AEGVRRLGEGGSDPIGQ 861 P + + E R EI + +G+++ EG +R G+ + G Sbjct: 1216 VPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGD 1275 Query: 862 AAAKDAVGLSKD---EAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHE 918 AK+ V D E +K +L S+GE G EK E H Sbjct: 1276 EEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKE-------HKEV 1328 Query: 919 VAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGE 978 R +SE+ E +S+ + S E+ ED R +++A L Sbjct: 1329 KGRNRRKVSSEDSE-----------DSDFQESGVSEEVSESEDEQRPRTRSAKKAELEEN 1377 Query: 979 EPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEG-SLAKEAFLCKEDVEGEEMVTE 1037 + + ++K+ R R++V E S E S ++E KE+ E EE E Sbjct: 1378 QRSYKQKKKRR---------------RIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEE 1422 Query: 1038 AEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQK 1097 E E+D + K R+ K ++ +T + E EE + A ++ + K + Sbjct: 1423 EEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREV 1482 Query: 1098 LKAEEGE-------TETEVRAEEETKAP 1118 ++ E+ T+ + +EETK P Sbjct: 1483 IEIEDASPTKCPITTKLVLDEDEETKEP 1510 Score = 69.3 bits (168), Expect = 3e-11 Identities = 209/1195 (17%), Positives = 443/1195 (37%), Gaps = 164/1195 (13%) Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAV 472 KEK+T++ + + K E K RK + ++ +I +++ +S K Q + + V Sbjct: 387 KEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRK---QVDSEHMHQNVPTE 443 Query: 473 EEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLD 532 E+ T+K G+ D +E E Q E +N D+ + +P S + Sbjct: 444 EQRTNKSTGGEHKKSDRKE---------------EPQYEPANTSEDLDMDIVSVPSSVPE 488 Query: 533 DKKDNLDPEKESETSSQKAPDARDNV---------------KDENDGCSESELEEDKQDM 577 D +NL+ E ++S D KD G + +++ Sbjct: 489 DIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKEL 548 Query: 578 KTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSS-SQELSENDKPRKSHLPI 636 + S S+ ++ + D++ + + + QE S+N+ HL + Sbjct: 549 YVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNE-----HL-V 602 Query: 637 EESLEIEIEDQEITKAD-VETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAE 695 E + + +E+ ++ ++ V+T P+ V T +E E + EK + +S Sbjct: 603 ENEVSLLLEESDLRRSPRVKTTPLRRPTETNPV----TSNSDEECNETVKEK--QKLSVP 656 Query: 696 EKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINS 755 ++KDK + + K K E + +LA+ + E + ++ Sbjct: 657 VRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAI--------LKEVSRMSH 708 Query: 756 NKESQQLVQKTYTLE------KKEAMEEDEAPQHR-----DADIVQGKGEAALWGEAGAV 804 + S + + +T K +A ++D+ + R +D KG++A ++ + Sbjct: 709 SSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSA---KSSII 765 Query: 805 HEAPLRAWKPTAE-QPELAEEF----------TEKREIP-------PGIERGAEGAAEAE 846 + + ++ EL +E T K+ IP E+ ++ + + Sbjct: 766 SKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQ 825 Query: 847 GVRRL---GEGGSDPIGQAAAKDAVGLSKDEAPEKQALM--LTVLETDKAASEGEQGLEK 901 G + L EG SD + ++ ++ + +M L + AS G++K Sbjct: 826 GHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDK 885 Query: 902 AVLANEAAALNLEHLHEVAALREAATSEEGEAEGGV--AVSDVGE-------SEEEASID 952 L+ + + + +VA +E + + + V +SD+ E S+E + D Sbjct: 886 --LSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDD 943 Query: 953 LEDTGPMEDTASKREDGSEEAILGGE--EPAKERKEVMRTETRLSPFTGEAEASRMQVSE 1010 + + + K D ++ I + E + + E + + F + + ++ Sbjct: 944 KKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTD 1003 Query: 1011 GSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSL 1070 G + + + K+++ + + + D ++ K RE+++ + S Sbjct: 1004 GEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSS 1063 Query: 1071 RKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEA 1130 RK T ++K++ +++LK E + ++ TK E+ S + + Sbjct: 1064 RKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTK----EIQSGSSSSD 1119 Query: 1131 PVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEH 1190 E+SE DN S K+ V + E +R S T+ Sbjct: 1120 AEESSE--DNKKKKQRTSSKKKAVIVKEK--------------------KRNSLRTSTKR 1157 Query: 1191 KDREELSSRENRALKEGHRQDGEGALAAPEAEPAGK---VQAPEGLIPATG-----QAEE 1242 K + SS + + GEG+ + +P + + + G ++G ++ Sbjct: 1158 KQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1217 Query: 1243 LAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEE------ 1296 + D D E R ++ + EE + + D++PEE Sbjct: 1218 VTVDDDDDDNDPENRI-----------AKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTG 1266 Query: 1297 EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEE 1356 ++++E + EA NSE D D E + + ++ + GE +T +E Sbjct: 1267 KQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSD--GESGEEKKTKPKE 1324 Query: 1357 REVLAGSETAEEKTIANKASSFSDV-AEEETWHQQDELVGKTAAAGKVVVEELARSGEEV 1415 + + G + + ++ S F + EE +DE +T +A K +EE RS ++ Sbjct: 1325 HKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQK 1384 Query: 1416 PAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFR 1475 + V + + E + +E+EE E +E + D + +K R Sbjct: 1385 KKRRRIKV-QEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIR 1443 Query: 1476 LGLSREGERELSPESLQAMATLPVKPDFTETREKQQHMVQGESETADVSPNNMQV 1530 L + +L E+ A+ + RE+++ ++ E D SP + Sbjct: 1444 KILK---DDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPI 1495 Score = 53.5 bits (127), Expect = 2e-06 Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 23/269 (8%) Query: 404 DKKPSLPKSRKEKSTEKGEELKKAEGKVRKE-----REYVIPK-RNEIKENKTSVSAKFS 457 D +P K R K E+ ++A+ +V E E P+ R+ + +K +VS S Sbjct: 1255 DDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGES 1314 Query: 458 AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517 +E KT KE KG+ ++V +D E++ E EV E + ++ Sbjct: 1315 GEEKKTKPKE------HKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRS 1368 Query: 518 QADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDM 577 ++ +S KK +E +S K+ + + E + E E EE+++D Sbjct: 1369 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1428 Query: 578 KTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIE 637 S + P + + D + T++ + ++E ++ R+ + Sbjct: 1429 NDDSKS-----PGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREV- 1482 Query: 638 ESLEIEIEDQEITKADVETKPMPIDESFE 666 IEIED TK + TK + +DE E Sbjct: 1483 ----IEIEDASPTKCPITTK-LVLDEDEE 1506 Score = 48.9 bits (115), Expect = 4e-05 Identities = 72/348 (20%), Positives = 137/348 (39%), Gaps = 58/348 (16%) Query: 405 KKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG 464 KK + K +K S + K+A+ + +N I E + Q+IK Sbjct: 1138 KKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD------EQKIKPV 1191 Query: 465 LKEVV---------TAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNE 515 + +V ++ +E SK P V +DD +N + + ++E K S+E Sbjct: 1192 TENLVLSSHTGFCQSSGDEALSKSVP-VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE 1250 Query: 516 EGQADVQMNG--------IPQSPLDDK-KDNLDPEKESETSSQKAPDARDNVKDENDGCS 566 +G +D + ++P D++ K+ ++ E +S++ K P R + S Sbjct: 1251 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS 1310 Query: 567 ESELEEDKQDMKTASST---SSRSHPYSSDSED----ESAVGDREAHTDSSTDESARRSS 619 + E E+K+ +R S DSED ES V + + ++ R + Sbjct: 1311 DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAK 1370 Query: 620 SQELSEND-----KPRKSHLPIEESLEIEI------EDQEITKADVETKPMPIDESFENV 668 EL EN K ++ + ++E E E++E + + E + +E EN Sbjct: 1371 KAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDEND 1430 Query: 669 LKEGTEKGTQEIAEGLS---------------EKSGKHVSAEEKEKDK 701 + KG ++I + L E+ K ++ E+E++K Sbjct: 1431 DSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK 1478 Score = 37.0 bits (84), Expect = 0.15 Identities = 54/256 (21%), Positives = 97/256 (37%), Gaps = 27/256 (10%) Query: 959 MEDTASKREDGSEEAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRM---- 1006 ++D+ S S A++ +E K+ K+++ T L T +E S Sbjct: 293 LDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLR 352 Query: 1007 QVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 Q+ + K +ED+ E +A N+E + KE + + RK E+P Sbjct: 353 QLKAFKSVLADIKKAHLALEEDLNSEFRAMDA-VNKEKNTKEHKVIDAKFETKARKGEKP 411 Query: 1067 KTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126 +L K D + E + K D+ Q + EE T E + E + Sbjct: 412 -CALEKKDISKSEAKLSR--KQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEP 468 Query: 1127 ENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEAR 1186 N + ++ P + ED IFE E ++E +++ +G G +E Sbjct: 469 ANTSEDLDMDIVSVPSSVPED--------IFE---NLETAMEVQSSVDHQGDGSSGTEQE 517 Query: 1187 DTEHKDREELSSRENR 1202 + +SS++NR Sbjct: 518 VESSSVKLNISSKDNR 533 Score = 36.6 bits (83), Expect = 0.19 Identities = 142/741 (19%), Positives = 269/741 (36%), Gaps = 115/741 (15%) Query: 864 AKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNL-----EHLHE 918 A DAV +K++ ++ ++ ET E LEK ++ A L+ EH+H+ Sbjct: 381 AMDAV--NKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQ 438 Query: 919 VAALREAATS-------------EEGEAEGGVAVSDV--------GESEEEASIDLEDTG 957 E T+ EE + E D+ E+ +LE Sbjct: 439 NVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAM 498 Query: 958 PMEDTASKREDGS-------EEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVS- 1009 ++ + + DGS E + + +K+ + ++++T + T E VS Sbjct: 499 EVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTT-AKVTKELYVKLTPVSL 557 Query: 1010 EGSPEEGSLAKEAFLCKEDVEGEEMVTEAE----ANREDDRKEILPKELDLARER---RK 1062 SP +G+ +E K+ + + + E D + ++ E+ L E R+ Sbjct: 558 SNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRR 617 Query: 1063 AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAP-PNE 1121 + R KT+ + +E VT + + + KE+QKL + + ++ P PN+ Sbjct: 618 SPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNK 677 Query: 1122 MGSDAENEAPVEASELSDNPGLLGE------DSLKETVVPIFEATPGFEKSLENITALRK 1175 + ++E + S+ + +L E S +T + L+ Sbjct: 678 LPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDD 737 Query: 1176 EGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 +G +R S ++ ++ S++ + K+ + E + E E K + G Sbjct: 738 KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAAR 797 Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPE 1295 T + KD DS E + G+D K +E +D E Sbjct: 798 TT-KKRIPNTKDFDSS---EDEKHSKKGMD-----------NQGHKNLKTSQEGSSDDAE 842 Query: 1296 EEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAE 1355 ++++E E D+++ ME K + V+ L G E + T+ E Sbjct: 843 RKQERETFSSAEGTVDKDTT---IMELRDRLPKKQ-QASASTDGVDKL-SGKEQSFTSLE 897 Query: 1356 EREVLAGSETAEE---KTIANKASSFSDVAEE-------ETWHQQDELVGKTAAAGK--- 1402 R+V E ++ KT SD+AE+ + + D+ K K Sbjct: 898 VRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP 957 Query: 1403 -------VVVEELARSG----EEVPAAEEM--------TVTYTTEAGVGTPGALERKTSG 1443 + +E+ S E++P EE+ + T G + KTS Sbjct: 958 SDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTS- 1016 Query: 1444 LGQEQEEGSEGQEAATGSGDG-------RQETGA--AEKFRLGLSREGERELSPESLQAM 1494 ++++E S+ E +TG GD + + GA EK R L + R+ S Sbjct: 1017 --KKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDT 1074 Query: 1495 ATLPVKPDFTETREKQQHMVQ 1515 +K D + +K+ ++ Sbjct: 1075 EKYSMKEDGCNSSDKRLKRIE 1095 Score = 33.9 bits (76), Expect = 1.2 Identities = 25/99 (25%), Positives = 42/99 (42%), Gaps = 12/99 (12%) Query: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSS-------- 592 E+ ETSS N + S S++ E+ ++ T+SS S+S S Sbjct: 27 EESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIV 86 Query: 593 ----DSEDESAVGDREAHTDSSTDESARRSSSQELSEND 627 +S+DE + D + D+S + S + Q L + D Sbjct: 87 TKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKED 125 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 80.9 bits (198), Expect = 9e-15 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%) Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471 +T+K +EL+ KVR E E ++ + +E S S K + E + G L E Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805 Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531 + + + K +++ E+D + E E GE + + +A++ + Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1857 Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588 + E E+E + A D + +E ++++EE ++ AS S R Sbjct: 1858 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910 Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645 D+ + + E ++ E A ++ EL + L +E E+E Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705 Q A+ E + +E + L E Q A L E EE + + + Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2029 Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765 +ES Q++ LA A +E A + ++ +Q +Q+ Sbjct: 2030 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067 Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825 TL++++++ D ++G+ EAA A EA ++A + A+ EE Sbjct: 2068 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2113 Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885 ER + A E R + ++ + + A ++A ++ E + Sbjct: 2114 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164 Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940 E +K EQ L +KA + E L L E H+ L E + EA E S Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224 Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993 V E + +E+ ++ R+ + + L +E A++ K+V R Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2282 Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053 LS EA R E ++ +LA E + E+M EA R E+L ++ Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2335 Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112 +LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE Sbjct: 2336 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2382 Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172 E K EM S A+ A +A +GE + + + T ++LE I Sbjct: 2383 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2438 Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232 + + ERL EA +++E+L E L ++E VQ E Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2483 Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292 L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542 Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346 + EE + E E R E +E + Q+ E + E L Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2601 Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400 E A E + S+ A KT+ N + AE E H D L K +A A Sbjct: 2602 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2661 Query: 1401 GKVVVEELARSGEEVPAAEEM 1421 G + EEL R + +E+ Sbjct: 2662 GILSAEELQRLAQGHTTVDEL 2682 Score = 72.0 bits (175), Expect = 4e-12 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%) Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470 K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590 Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525 +E + L ++ E + + E E+ E + E+ K+NE + +Q Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650 Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585 + Q + EK+ E + + +AR K E + EL E + + + + + Sbjct: 1651 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704 Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645 +++ E ++ E R+ +EL+ + + + LE E+ Sbjct: 1705 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699 +A++E + E + +EK Q + AE L+E++ + + E+ K Sbjct: 1759 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814 Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759 + +L EE A+ + + + + A+G T E A E+ Sbjct: 1815 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863 Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819 ++L + + E++A QH+ ADI + + ++ + L + T Q Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1920 Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879 EE E + E+ A G AE E LG S+ +K+ L EA ++ Sbjct: 1921 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1973 Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939 L E ++ E E+ ++K++ A E AA + AAL E + + E + Sbjct: 1974 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2024 Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997 + E E + L ++ A KR E+A ++ +E ++ ++ E L Sbjct: 2025 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079 Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057 GEAEA+R E EE + E +E + V EAE ++ ++ A Sbjct: 2080 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2125 Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 + R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T Sbjct: 2126 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2179 Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168 ++ + ++ E LL E+ LK E+ L E Sbjct: 2180 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238 Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227 ++ L+ E R RD ++ R E +K+ + ++AA EA ++ Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296 Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284 A E L AE++ + + L+ AE +L+ Q+ +A+E ++ Sbjct: 2297 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2348 Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327 +E+ + EE + + TLE E + + + E + Q Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408 Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376 + E +V V+ L + ++ AE RE +A E +EK + +A Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2467 Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407 +EE QQ++L+ +T A + + E Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498 Score = 66.2 bits (160), Expect = 2e-10 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470 +S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2011 Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529 E + +K + + + E +QE+ + + ++ + EK++ A Q Q Sbjct: 2012 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2067 Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587 L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++ Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127 Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643 + + ++ ++EA + +++A R +E +K +K L + +E E Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187 Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703 + + + + + +DE + + E TE Q ++ E V EE K K++ Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2246 Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762 + E+ A + +DK L+E + +A A ++ E A + E Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2302 Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822 Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A Sbjct: 2303 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2354 Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882 ++ E+ + G + EAE R+L + + E + L Sbjct: 2355 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2386 Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942 L V E +A + E+ ++ +A + E LH E AT E+ + + Sbjct: 2387 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2439 Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 +S+ +A E +E K + ++ L EE ++E + ET+ Sbjct: 2440 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2490 Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058 +Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R Sbjct: 2491 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547 Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111 RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607 Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171 S+ + V A++ N G D+L P EA P E S + Sbjct: 2608 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2647 Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208 LR++ +RL EA LS+ E + L +GH Sbjct: 2648 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2676 Score = 59.7 bits (143), Expect = 2e-08 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%) Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945 +E ++ +E ++ E+ LA AAL + A + A +E E + + Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403 Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003 EEA++D + E+ R+ E + + +R E + + EA Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463 Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063 + Q E +L A E+ E ++ + EA R R+++ D ++ +R+A Sbjct: 1464 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1513 Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118 E S K ++E RE+ AL EE +L+AEE E + EV + + Sbjct: 1514 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1566 Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178 AE E + + ++ L E SL+E V + + E+ + ++ Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1619 Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 ER AR+ ++ E + N AL+ + + +LA EAE + + E Sbjct: 1620 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1674 Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294 G+AEE A + + LE + + G Q+ +A E ++ + E ++ Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1729 Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354 + E++ L+ EA + + E + E + + A E T+E + Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1786 Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408 + E AG E A + +A +A +AEE+ Q+ A A +V+ E+L Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1839 Query: 1409 ARSGE 1413 A GE Sbjct: 1840 AAIGE 1844 Score = 51.2 bits (121), Expect = 8e-06 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%) Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091 EE AE R ++R+ + E++ A E+++ + K +ERE +++E Sbjct: 1345 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402 Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151 +EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++ Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1456 Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194 + + EAT G E L+ + A +E ++ + E R+ Sbjct: 1457 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515 Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239 EL+SR E A +E R ++ E L E E A +VQ + + Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575 Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297 AE A + A LE + + LR + + AE+ REEA E + Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635 Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357 L + ++ + E QK E A G+ E A +R Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1687 Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417 E LA E +++ +A + AE+E + E + +++ EELAR E A Sbjct: 1688 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1745 Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474 A + E +E + + +EE SE + + GR A E Sbjct: 1746 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804 Query: 1475 RL-GLSREGERE 1485 RL L+ E +R+ Sbjct: 1805 RLRALAEEAKRQ 1816 Score = 39.7 bits (91), Expect = 0.023 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%) Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855 E VH L K A E A+ E+++ +E +G +AEAE V L E Sbjct: 1000 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057 Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907 + P ++ + +G ++ A+ L L+T G QG E+ + A+E Sbjct: 1058 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116 Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 A L L A+L++ E + A+ D +E L+ D +R Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176 Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008 E ++ +A+L + + E + + R L + +A + Q+ Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236 Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 ++ L +E L +E E V E + + I EL L + + E Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296 Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120 + +K ++S +E E Q +K +ET R EEE + Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1353 Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180 + + E A VEA+ EK + + + Sbjct: 1354 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1385 Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 EA++ + + +EE+ RE A+ K +++ + + EAE K + E Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445 Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293 + + EE + LE +GG + L+ A AEE + +EEA + Sbjct: 1446 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502 Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353 ++E ++ E E +E + E + Q A+E L E AE Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1551 Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404 + R+V ETA+ E + +K +SF++ + Q+E V A + Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1609 Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464 E A+ E A E + AL L + EE ++ + A + Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1664 Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497 ++E E R G + E +REL+ + L+ L Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700 Score = 37.7 bits (86), Expect = 0.086 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%) Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512 SA+ TG K+ + + +L+D L+ + +D E+ E Sbjct: 4006 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4065 Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572 + + G D +MN I P DD K DP E + + + + D G L+E Sbjct: 4066 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4123 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632 K++ KT+S +S R + D E + S E+ R+ ++ Sbjct: 4124 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4167 Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662 +L + E E E E+ I+ +D K M ID Sbjct: 4168 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4196 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 80.9 bits (198), Expect = 9e-15 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%) Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471 +T+K +EL+ KVR E E ++ + +E S S K + E + G L E Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1809 Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531 + + + K +++ E+D + E E GE + + +A++ + Sbjct: 1810 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1861 Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588 + E E+E + A D + +E ++++EE ++ AS S R Sbjct: 1862 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1914 Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645 D+ + + E ++ E A ++ EL + L +E E+E Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705 Q A+ E + +E + L E Q A L E EE + + + Sbjct: 1975 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2033 Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765 +ES Q++ LA A +E A + ++ +Q +Q+ Sbjct: 2034 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2071 Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825 TL++++++ D ++G+ EAA A EA ++A + A+ EE Sbjct: 2072 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2117 Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885 ER + A E R + ++ + + A ++A ++ E + Sbjct: 2118 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168 Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940 E +K EQ L +KA + E L L E H+ L E + EA E S Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228 Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993 V E + +E+ ++ R+ + + L +E A++ K+V R Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2286 Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053 LS EA R E ++ +LA E + E+M EA R E+L ++ Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2339 Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112 +LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE Sbjct: 2340 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2386 Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172 E K EM S A+ A +A +GE + + + T ++LE I Sbjct: 2387 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2442 Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232 + + ERL EA +++E+L E L ++E VQ E Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2487 Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292 L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546 Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346 + EE + E E R E +E + Q+ E + E L Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2605 Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400 E A E + S+ A KT+ N + AE E H D L K +A A Sbjct: 2606 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2665 Query: 1401 GKVVVEELARSGEEVPAAEEM 1421 G + EEL R + +E+ Sbjct: 2666 GILSAEELQRLAQGHTTVDEL 2686 Score = 72.0 bits (175), Expect = 4e-12 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%) Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470 K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1594 Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525 +E + L ++ E + + E E+ E + E+ K+NE + +Q Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654 Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585 + Q + EK+ E + + +AR K E + EL E + + + + + Sbjct: 1655 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708 Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645 +++ E ++ E R+ +EL+ + + + LE E+ Sbjct: 1709 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699 +A++E + E + +EK Q + AE L+E++ + + E+ K Sbjct: 1763 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818 Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759 + +L EE A+ + + + + A+G T E A E+ Sbjct: 1819 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867 Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819 ++L + + E++A QH+ ADI + + ++ + L + T Q Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1924 Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879 EE E + E+ A G AE E LG S+ +K+ L EA ++ Sbjct: 1925 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1977 Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939 L E ++ E E+ ++K++ A E AA + AAL E + + E + Sbjct: 1978 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2028 Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997 + E E + L ++ A KR E+A ++ +E ++ ++ E L Sbjct: 2029 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083 Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057 GEAEA+R E EE + E +E + V EAE ++ ++ A Sbjct: 2084 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2129 Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 + R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T Sbjct: 2130 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2183 Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168 ++ + ++ E LL E+ LK E+ L E Sbjct: 2184 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242 Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227 ++ L+ E R RD ++ R E +K+ + ++AA EA ++ Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300 Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284 A E L AE++ + + L+ AE +L+ Q+ +A+E ++ Sbjct: 2301 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2352 Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327 +E+ + EE + + TLE E + + + E + Q Sbjct: 2353 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412 Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376 + E +V V+ L + ++ AE RE +A E +EK + +A Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2471 Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407 +EE QQ++L+ +T A + + E Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2502 Score = 66.2 bits (160), Expect = 2e-10 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470 +S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2015 Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529 E + +K + + + E +QE+ + + ++ + EK++ A Q Q Sbjct: 2016 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2071 Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587 L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++ Sbjct: 2072 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131 Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643 + + ++ ++EA + +++A R +E +K +K L + +E E Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191 Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703 + + + + + +DE + + E TE Q ++ E V EE K K++ Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2250 Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762 + E+ A + +DK L+E + +A A ++ E A + E Sbjct: 2251 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2306 Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822 Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A Sbjct: 2307 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2358 Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882 ++ E+ + G + EAE R+L + + E + L Sbjct: 2359 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2390 Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942 L V E +A + E+ ++ +A + E LH E AT E+ + + Sbjct: 2391 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2443 Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 +S+ +A E +E K + ++ L EE ++E + ET+ Sbjct: 2444 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2494 Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058 +Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R Sbjct: 2495 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2551 Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111 RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA Sbjct: 2552 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2611 Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171 S+ + V A++ N G D+L P EA P E S + Sbjct: 2612 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2651 Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208 LR++ +RL EA LS+ E + L +GH Sbjct: 2652 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2680 Score = 59.7 bits (143), Expect = 2e-08 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%) Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945 +E ++ +E ++ E+ LA AAL + A + A +E E + + Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407 Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003 EEA++D + E+ R+ E + + +R E + + EA Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1467 Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063 + Q E +L A E+ E ++ + EA R R+++ D ++ +R+A Sbjct: 1468 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1517 Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118 E S K ++E RE+ AL EE +L+AEE E + EV + + Sbjct: 1518 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1570 Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178 AE E + + ++ L E SL+E V + + E+ + ++ Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1623 Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 ER AR+ ++ E + N AL+ + + +LA EAE + + E Sbjct: 1624 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1678 Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294 G+AEE A + + LE + + G Q+ +A E ++ + E ++ Sbjct: 1679 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1733 Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354 + E++ L+ EA + + E + E + + A E T+E + Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1790 Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408 + E AG E A + +A +A +AEE+ Q+ A A +V+ E+L Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1843 Query: 1409 ARSGE 1413 A GE Sbjct: 1844 AAIGE 1848 Score = 51.2 bits (121), Expect = 8e-06 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%) Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091 EE AE R ++R+ + E++ A E+++ + K +ERE +++E Sbjct: 1349 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406 Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151 +EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++ Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1460 Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194 + + EAT G E L+ + A +E ++ + E R+ Sbjct: 1461 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519 Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239 EL+SR E A +E R ++ E L E E A +VQ + + Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579 Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297 AE A + A LE + + LR + + AE+ REEA E + Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639 Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357 L + ++ + E QK E A G+ E A +R Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1691 Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417 E LA E +++ +A + AE+E + E + +++ EELAR E A Sbjct: 1692 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1749 Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474 A + E +E + + +EE SE + + GR A E Sbjct: 1750 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1808 Query: 1475 RL-GLSREGERE 1485 RL L+ E +R+ Sbjct: 1809 RLRALAEEAKRQ 1820 Score = 39.7 bits (91), Expect = 0.023 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%) Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855 E VH L K A E A+ E+++ +E +G +AEAE V L E Sbjct: 1004 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061 Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907 + P ++ + +G ++ A+ L L+T G QG E+ + A+E Sbjct: 1062 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1120 Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 A L L A+L++ E + A+ D +E L+ D +R Sbjct: 1121 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1180 Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008 E ++ +A+L + + E + + R L + +A + Q+ Sbjct: 1181 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1240 Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 ++ L +E L +E E V E + + I EL L + + E Sbjct: 1241 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1300 Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120 + +K ++S +E E Q +K +ET R EEE + Sbjct: 1301 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1357 Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180 + + E A VEA+ EK + + + Sbjct: 1358 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1389 Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 EA++ + + +EE+ RE A+ K +++ + + EAE K + E Sbjct: 1390 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449 Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293 + + EE + LE +GG + L+ A AEE + +EEA + Sbjct: 1450 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506 Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353 ++E ++ E E +E + E + Q A+E L E AE Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1555 Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404 + R+V ETA+ E + +K +SF++ + Q+E V A + Sbjct: 1556 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1613 Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464 E A+ E A E + AL L + EE ++ + A + Sbjct: 1614 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1668 Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497 ++E E R G + E +REL+ + L+ L Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1704 Score = 37.7 bits (86), Expect = 0.086 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%) Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512 SA+ TG K+ + + +L+D L+ + +D E+ E Sbjct: 4010 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4069 Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572 + + G D +MN I P DD K DP E + + + + D G L+E Sbjct: 4070 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4127 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632 K++ KT+S +S R + D E + S E+ R+ ++ Sbjct: 4128 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4171 Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662 +L + E E E E+ I+ +D K M ID Sbjct: 4172 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4200 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 80.9 bits (198), Expect = 9e-15 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%) Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471 +T+K +EL+ KVR E E ++ + +E S S K + E + G L E Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805 Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531 + + + K +++ E+D + E E GE + + +A++ + Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1857 Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588 + E E+E + A D + +E ++++EE ++ AS S R Sbjct: 1858 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910 Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645 D+ + + E ++ E A ++ EL + L +E E+E Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705 Q A+ E + +E + L E Q A L E EE + + + Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2029 Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765 +ES Q++ LA A +E A + ++ +Q +Q+ Sbjct: 2030 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067 Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825 TL++++++ D ++G+ EAA A EA ++A + A+ EE Sbjct: 2068 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2113 Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885 ER + A E R + ++ + + A ++A ++ E + Sbjct: 2114 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164 Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940 E +K EQ L +KA + E L L E H+ L E + EA E S Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224 Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993 V E + +E+ ++ R+ + + L +E A++ K+V R Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2282 Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053 LS EA R E ++ +LA E + E+M EA R E+L ++ Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2335 Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112 +LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE Sbjct: 2336 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2382 Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172 E K EM S A+ A +A +GE + + + T ++LE I Sbjct: 2383 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2438 Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232 + + ERL EA +++E+L E L ++E VQ E Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2483 Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292 L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542 Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346 + EE + E E R E +E + Q+ E + E L Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2601 Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400 E A E + S+ A KT+ N + AE E H D L K +A A Sbjct: 2602 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2661 Query: 1401 GKVVVEELARSGEEVPAAEEM 1421 G + EEL R + +E+ Sbjct: 2662 GILSAEELQRLAQGHTTVDEL 2682 Score = 72.0 bits (175), Expect = 4e-12 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%) Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470 K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590 Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525 +E + L ++ E + + E E+ E + E+ K+NE + +Q Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650 Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585 + Q + EK+ E + + +AR K E + EL E + + + + + Sbjct: 1651 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704 Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645 +++ E ++ E R+ +EL+ + + + LE E+ Sbjct: 1705 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699 +A++E + E + +EK Q + AE L+E++ + + E+ K Sbjct: 1759 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814 Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759 + +L EE A+ + + + + A+G T E A E+ Sbjct: 1815 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863 Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819 ++L + + E++A QH+ ADI + + ++ + L + T Q Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1920 Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879 EE E + E+ A G AE E LG S+ +K+ L EA ++ Sbjct: 1921 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1973 Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939 L E ++ E E+ ++K++ A E AA + AAL E + + E + Sbjct: 1974 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2024 Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997 + E E + L ++ A KR E+A ++ +E ++ ++ E L Sbjct: 2025 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079 Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057 GEAEA+R E EE + E +E + V EAE ++ ++ A Sbjct: 2080 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2125 Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 + R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T Sbjct: 2126 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2179 Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168 ++ + ++ E LL E+ LK E+ L E Sbjct: 2180 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238 Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227 ++ L+ E R RD ++ R E +K+ + ++AA EA ++ Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296 Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284 A E L AE++ + + L+ AE +L+ Q+ +A+E ++ Sbjct: 2297 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2348 Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327 +E+ + EE + + TLE E + + + E + Q Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408 Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376 + E +V V+ L + ++ AE RE +A E +EK + +A Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2467 Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407 +EE QQ++L+ +T A + + E Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498 Score = 66.2 bits (160), Expect = 2e-10 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470 +S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2011 Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529 E + +K + + + E +QE+ + + ++ + EK++ A Q Q Sbjct: 2012 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2067 Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587 L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++ Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127 Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643 + + ++ ++EA + +++A R +E +K +K L + +E E Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187 Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703 + + + + + +DE + + E TE Q ++ E V EE K K++ Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2246 Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762 + E+ A + +DK L+E + +A A ++ E A + E Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2302 Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822 Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A Sbjct: 2303 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2354 Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882 ++ E+ + G + EAE R+L + + E + L Sbjct: 2355 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2386 Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942 L V E +A + E+ ++ +A + E LH E AT E+ + + Sbjct: 2387 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2439 Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 +S+ +A E +E K + ++ L EE ++E + ET+ Sbjct: 2440 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2490 Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058 +Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R Sbjct: 2491 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547 Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111 RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607 Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171 S+ + V A++ N G D+L P EA P E S + Sbjct: 2608 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2647 Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208 LR++ +RL EA LS+ E + L +GH Sbjct: 2648 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2676 Score = 59.7 bits (143), Expect = 2e-08 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%) Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945 +E ++ +E ++ E+ LA AAL + A + A +E E + + Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403 Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003 EEA++D + E+ R+ E + + +R E + + EA Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463 Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063 + Q E +L A E+ E ++ + EA R R+++ D ++ +R+A Sbjct: 1464 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1513 Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118 E S K ++E RE+ AL EE +L+AEE E + EV + + Sbjct: 1514 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1566 Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178 AE E + + ++ L E SL+E V + + E+ + ++ Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1619 Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 ER AR+ ++ E + N AL+ + + +LA EAE + + E Sbjct: 1620 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1674 Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294 G+AEE A + + LE + + G Q+ +A E ++ + E ++ Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1729 Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354 + E++ L+ EA + + E + E + + A E T+E + Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1786 Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408 + E AG E A + +A +A +AEE+ Q+ A A +V+ E+L Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1839 Query: 1409 ARSGE 1413 A GE Sbjct: 1840 AAIGE 1844 Score = 51.2 bits (121), Expect = 8e-06 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%) Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091 EE AE R ++R+ + E++ A E+++ + K +ERE +++E Sbjct: 1345 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402 Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151 +EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++ Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1456 Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194 + + EAT G E L+ + A +E ++ + E R+ Sbjct: 1457 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515 Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239 EL+SR E A +E R ++ E L E E A +VQ + + Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575 Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297 AE A + A LE + + LR + + AE+ REEA E + Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635 Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357 L + ++ + E QK E A G+ E A +R Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1687 Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417 E LA E +++ +A + AE+E + E + +++ EELAR E A Sbjct: 1688 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1745 Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474 A + E +E + + +EE SE + + GR A E Sbjct: 1746 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804 Query: 1475 RL-GLSREGERE 1485 RL L+ E +R+ Sbjct: 1805 RLRALAEEAKRQ 1816 Score = 39.7 bits (91), Expect = 0.023 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%) Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855 E VH L K A E A+ E+++ +E +G +AEAE V L E Sbjct: 1000 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057 Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907 + P ++ + +G ++ A+ L L+T G QG E+ + A+E Sbjct: 1058 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116 Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 A L L A+L++ E + A+ D +E L+ D +R Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176 Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008 E ++ +A+L + + E + + R L + +A + Q+ Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236 Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 ++ L +E L +E E V E + + I EL L + + E Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296 Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120 + +K ++S +E E Q +K +ET R EEE + Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1353 Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180 + + E A VEA+ EK + + + Sbjct: 1354 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1385 Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 EA++ + + +EE+ RE A+ K +++ + + EAE K + E Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445 Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293 + + EE + LE +GG + L+ A AEE + +EEA + Sbjct: 1446 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502 Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353 ++E ++ E E +E + E + Q A+E L E AE Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1551 Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404 + R+V ETA+ E + +K +SF++ + Q+E V A + Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1609 Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464 E A+ E A E + AL L + EE ++ + A + Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1664 Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497 ++E E R G + E +REL+ + L+ L Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700 Score = 37.7 bits (86), Expect = 0.086 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%) Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512 SA+ TG K+ + + +L+D L+ + +D E+ E Sbjct: 4006 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4065 Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572 + + G D +MN I P DD K DP E + + + + D G L+E Sbjct: 4066 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4123 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632 K++ KT+S +S R + D E + S E+ R+ ++ Sbjct: 4124 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4167 Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662 +L + E E E E+ I+ +D K M ID Sbjct: 4168 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4196 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 80.9 bits (198), Expect = 9e-15 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%) Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471 +T+K +EL+ KVR E E ++ + +E S S K + E + G L E Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773 Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531 + + + K +++ E+D + E E GE + + +A++ + Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1825 Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588 + E E+E + A D + +E ++++EE ++ AS S R Sbjct: 1826 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1878 Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645 D+ + + E ++ E A ++ EL + L +E E+E Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705 Q A+ E + +E + L E Q A L E EE + + + Sbjct: 1939 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 1997 Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765 +ES Q++ LA A +E A + ++ +Q +Q+ Sbjct: 1998 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2035 Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825 TL++++++ D ++G+ EAA A EA ++A + A+ EE Sbjct: 2036 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2081 Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885 ER + A E R + ++ + + A ++A ++ E + Sbjct: 2082 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132 Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940 E +K EQ L +KA + E L L E H+ L E + EA E S Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192 Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993 V E + +E+ ++ R+ + + L +E A++ K+V R Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2250 Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053 LS EA R E ++ +LA E + E+M EA R E+L ++ Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2303 Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112 +LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE Sbjct: 2304 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2350 Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172 E K EM S A+ A +A +GE + + + T ++LE I Sbjct: 2351 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2406 Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232 + + ERL EA +++E+L E L ++E VQ E Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2451 Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292 L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E Sbjct: 2452 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510 Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346 + EE + E E R E +E + Q+ E + E L Sbjct: 2511 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2569 Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400 E A E + S+ A KT+ N + AE E H D L K +A A Sbjct: 2570 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2629 Query: 1401 GKVVVEELARSGEEVPAAEEM 1421 G + EEL R + +E+ Sbjct: 2630 GILSAEELQRLAQGHTTVDEL 2650 Score = 72.0 bits (175), Expect = 4e-12 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%) Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470 K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1558 Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525 +E + L ++ E + + E E+ E + E+ K+NE + +Q Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618 Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585 + Q + EK+ E + + +AR K E + EL E + + + + + Sbjct: 1619 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672 Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645 +++ E ++ E R+ +EL+ + + + LE E+ Sbjct: 1673 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699 +A++E + E + +EK Q + AE L+E++ + + E+ K Sbjct: 1727 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782 Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759 + +L EE A+ + + + + A+G T E A E+ Sbjct: 1783 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831 Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819 ++L + + E++A QH+ ADI + + ++ + L + T Q Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1888 Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879 EE E + E+ A G AE E LG S+ +K+ L EA ++ Sbjct: 1889 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1941 Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939 L E ++ E E+ ++K++ A E AA + AAL E + + E + Sbjct: 1942 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 1992 Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997 + E E + L ++ A KR E+A ++ +E ++ ++ E L Sbjct: 1993 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047 Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057 GEAEA+R E EE + E +E + V EAE ++ ++ A Sbjct: 2048 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2093 Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 + R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T Sbjct: 2094 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2147 Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168 ++ + ++ E LL E+ LK E+ L E Sbjct: 2148 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206 Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227 ++ L+ E R RD ++ R E +K+ + ++AA EA ++ Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264 Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284 A E L AE++ + + L+ AE +L+ Q+ +A+E ++ Sbjct: 2265 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2316 Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327 +E+ + EE + + TLE E + + + E + Q Sbjct: 2317 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376 Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376 + E +V V+ L + ++ AE RE +A E +EK + +A Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2435 Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407 +EE QQ++L+ +T A + + E Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2466 Score = 66.2 bits (160), Expect = 2e-10 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470 +S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 1979 Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529 E + +K + + + E +QE+ + + ++ + EK++ A Q Q Sbjct: 1980 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2035 Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587 L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++ Sbjct: 2036 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095 Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643 + + ++ ++EA + +++A R +E +K +K L + +E E Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155 Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703 + + + + + +DE + + E TE Q ++ E V EE K K++ Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2214 Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762 + E+ A + +DK L+E + +A A ++ E A + E Sbjct: 2215 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2270 Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822 Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A Sbjct: 2271 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2322 Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882 ++ E+ + G + EAE R+L + + E + L Sbjct: 2323 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2354 Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942 L V E +A + E+ ++ +A + E LH E AT E+ + + Sbjct: 2355 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2407 Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 +S+ +A E +E K + ++ L EE ++E + ET+ Sbjct: 2408 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2458 Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058 +Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R Sbjct: 2459 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2515 Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111 RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA Sbjct: 2516 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2575 Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171 S+ + V A++ N G D+L P EA P E S + Sbjct: 2576 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2615 Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208 LR++ +RL EA LS+ E + L +GH Sbjct: 2616 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2644 Score = 59.7 bits (143), Expect = 2e-08 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%) Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945 +E ++ +E ++ E+ LA AAL + A + A +E E + + Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371 Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003 EEA++D + E+ R+ E + + +R E + + EA Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1431 Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063 + Q E +L A E+ E ++ + EA R R+++ D ++ +R+A Sbjct: 1432 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1481 Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118 E S K ++E RE+ AL EE +L+AEE E + EV + + Sbjct: 1482 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1534 Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178 AE E + + ++ L E SL+E V + + E+ + ++ Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1587 Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 ER AR+ ++ E + N AL+ + + +LA EAE + + E Sbjct: 1588 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1642 Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294 G+AEE A + + LE + + G Q+ +A E ++ + E ++ Sbjct: 1643 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1697 Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354 + E++ L+ EA + + E + E + + A E T+E + Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1754 Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408 + E AG E A + +A +A +AEE+ Q+ A A +V+ E+L Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1807 Query: 1409 ARSGE 1413 A GE Sbjct: 1808 AAIGE 1812 Score = 51.2 bits (121), Expect = 8e-06 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%) Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091 EE AE R ++R+ + E++ A E+++ + K +ERE +++E Sbjct: 1313 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370 Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151 +EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++ Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1424 Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194 + + EAT G E L+ + A +E ++ + E R+ Sbjct: 1425 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483 Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239 EL+SR E A +E R ++ E L E E A +VQ + + Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543 Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297 AE A + A LE + + LR + + AE+ REEA E + Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603 Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357 L + ++ + E QK E A G+ E A +R Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1655 Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417 E LA E +++ +A + AE+E + E + +++ EELAR E A Sbjct: 1656 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1713 Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474 A + E +E + + +EE SE + + GR A E Sbjct: 1714 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1772 Query: 1475 RL-GLSREGERE 1485 RL L+ E +R+ Sbjct: 1773 RLRALAEEAKRQ 1784 Score = 39.7 bits (91), Expect = 0.023 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%) Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855 E VH L K A E A+ E+++ +E +G +AEAE V L E Sbjct: 968 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025 Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907 + P ++ + +G ++ A+ L L+T G QG E+ + A+E Sbjct: 1026 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1084 Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 A L L A+L++ E + A+ D +E L+ D +R Sbjct: 1085 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1144 Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008 E ++ +A+L + + E + + R L + +A + Q+ Sbjct: 1145 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1204 Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 ++ L +E L +E E V E + + I EL L + + E Sbjct: 1205 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1264 Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120 + +K ++S +E E Q +K +ET R EEE + Sbjct: 1265 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1321 Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180 + + E A VEA+ EK + + + Sbjct: 1322 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1353 Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 EA++ + + +EE+ RE A+ K +++ + + EAE K + E Sbjct: 1354 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1413 Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293 + + EE + LE +GG + L+ A AEE + +EEA + Sbjct: 1414 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470 Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353 ++E ++ E E +E + E + Q A+E L E AE Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1519 Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404 + R+V ETA+ E + +K +SF++ + Q+E V A + Sbjct: 1520 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1577 Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464 E A+ E A E + AL L + EE ++ + A + Sbjct: 1578 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1632 Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497 ++E E R G + E +REL+ + L+ L Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1668 Score = 37.7 bits (86), Expect = 0.086 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%) Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512 SA+ TG K+ + + +L+D L+ + +D E+ E Sbjct: 3974 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4033 Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572 + + G D +MN I P DD K DP E + + + + D G L+E Sbjct: 4034 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4091 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632 K++ KT+S +S R + D E + S E+ R+ ++ Sbjct: 4092 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4135 Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662 +L + E E E E+ I+ +D K M ID Sbjct: 4136 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4164 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 80.9 bits (198), Expect = 9e-15 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%) Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471 +T+K +EL+ KVR E E ++ + +E S S K + E + G L E Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1942 Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531 + + + K +++ E+D + E E GE + + +A++ + Sbjct: 1943 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1994 Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588 + E E+E + A D + +E ++++EE ++ AS S R Sbjct: 1995 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 2047 Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645 D+ + + E ++ E A ++ EL + L +E E+E Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705 Q A+ E + +E + L E Q A L E EE + + + Sbjct: 2108 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2166 Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765 +ES Q++ LA A +E A + ++ +Q +Q+ Sbjct: 2167 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2204 Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825 TL++++++ D ++G+ EAA A EA ++A + A+ EE Sbjct: 2205 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2250 Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885 ER + A E R + ++ + + A ++A ++ E + Sbjct: 2251 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301 Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940 E +K EQ L +KA + E L L E H+ L E + EA E S Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361 Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993 V E + +E+ ++ R+ + + L +E A++ K+V R Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2419 Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053 LS EA R E ++ +LA E + E+M EA R E+L ++ Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2472 Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112 +LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE Sbjct: 2473 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2519 Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172 E K EM S A+ A +A +GE + + + T ++LE I Sbjct: 2520 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2575 Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232 + + ERL EA +++E+L E L ++E VQ E Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2620 Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292 L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679 Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346 + EE + E E R E +E + Q+ E + E L Sbjct: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2738 Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400 E A E + S+ A KT+ N + AE E H D L K +A A Sbjct: 2739 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2798 Query: 1401 GKVVVEELARSGEEVPAAEEM 1421 G + EEL R + +E+ Sbjct: 2799 GILSAEELQRLAQGHTTVDEL 2819 Score = 72.0 bits (175), Expect = 4e-12 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%) Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470 K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1727 Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525 +E + L ++ E + + E E+ E + E+ K+NE + +Q Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787 Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585 + Q + EK+ E + + +AR K E + EL E + + + + + Sbjct: 1788 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841 Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645 +++ E ++ E R+ +EL+ + + + LE E+ Sbjct: 1842 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699 +A++E + E + +EK Q + AE L+E++ + + E+ K Sbjct: 1896 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951 Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759 + +L EE A+ + + + + A+G T E A E+ Sbjct: 1952 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000 Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819 ++L + + E++A QH+ ADI + + ++ + L + T Q Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 2057 Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879 EE E + E+ A G AE E LG S+ +K+ L EA ++ Sbjct: 2058 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 2110 Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939 L E ++ E E+ ++K++ A E AA + AAL E + + E + Sbjct: 2111 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2161 Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997 + E E + L ++ A KR E+A ++ +E ++ ++ E L Sbjct: 2162 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216 Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057 GEAEA+R E EE + E +E + V EAE ++ ++ A Sbjct: 2217 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2262 Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 + R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T Sbjct: 2263 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2316 Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168 ++ + ++ E LL E+ LK E+ L E Sbjct: 2317 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375 Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227 ++ L+ E R RD ++ R E +K+ + ++AA EA ++ Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2433 Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284 A E L AE++ + + L+ AE +L+ Q+ +A+E ++ Sbjct: 2434 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2485 Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327 +E+ + EE + + TLE E + + + E + Q Sbjct: 2486 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545 Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376 + E +V V+ L + ++ AE RE +A E +EK + +A Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2604 Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407 +EE QQ++L+ +T A + + E Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2635 Score = 66.2 bits (160), Expect = 2e-10 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470 +S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2148 Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529 E + +K + + + E +QE+ + + ++ + EK++ A Q Q Sbjct: 2149 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2204 Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587 L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++ Sbjct: 2205 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264 Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643 + + ++ ++EA + +++A R +E +K +K L + +E E Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324 Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703 + + + + + +DE + + E TE Q ++ E V EE K K++ Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2383 Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762 + E+ A + +DK L+E + +A A ++ E A + E Sbjct: 2384 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2439 Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822 Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A Sbjct: 2440 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2491 Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882 ++ E+ + G + EAE R+L + + E + L Sbjct: 2492 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2523 Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942 L V E +A + E+ ++ +A + E LH E AT E+ + + Sbjct: 2524 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2576 Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 +S+ +A E +E K + ++ L EE ++E + ET+ Sbjct: 2577 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2627 Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058 +Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R Sbjct: 2628 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2684 Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111 RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA Sbjct: 2685 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2744 Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171 S+ + V A++ N G D+L P EA P E S + Sbjct: 2745 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2784 Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208 LR++ +RL EA LS+ E + L +GH Sbjct: 2785 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2813 Score = 59.7 bits (143), Expect = 2e-08 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%) Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945 +E ++ +E ++ E+ LA AAL + A + A +E E + + Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540 Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003 EEA++D + E+ R+ E + + +R E + + EA Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1600 Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063 + Q E +L A E+ E ++ + EA R R+++ D ++ +R+A Sbjct: 1601 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1650 Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118 E S K ++E RE+ AL EE +L+AEE E + EV + + Sbjct: 1651 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1703 Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178 AE E + + ++ L E SL+E V + + E+ + ++ Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1756 Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 ER AR+ ++ E + N AL+ + + +LA EAE + + E Sbjct: 1757 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1811 Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294 G+AEE A + + LE + + G Q+ +A E ++ + E ++ Sbjct: 1812 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1866 Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354 + E++ L+ EA + + E + E + + A E T+E + Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1923 Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408 + E AG E A + +A +A +AEE+ Q+ A A +V+ E+L Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1976 Query: 1409 ARSGE 1413 A GE Sbjct: 1977 AAIGE 1981 Score = 51.2 bits (121), Expect = 8e-06 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%) Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091 EE AE R ++R+ + E++ A E+++ + K +ERE +++E Sbjct: 1482 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539 Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151 +EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++ Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1593 Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194 + + EAT G E L+ + A +E ++ + E R+ Sbjct: 1594 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652 Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239 EL+SR E A +E R ++ E L E E A +VQ + + Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712 Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297 AE A + A LE + + LR + + AE+ REEA E + Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772 Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357 L + ++ + E QK E A G+ E A +R Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1824 Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417 E LA E +++ +A + AE+E + E + +++ EELAR E A Sbjct: 1825 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1882 Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474 A + E +E + + +EE SE + + GR A E Sbjct: 1883 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1941 Query: 1475 RL-GLSREGERE 1485 RL L+ E +R+ Sbjct: 1942 RLRALAEEAKRQ 1953 Score = 39.7 bits (91), Expect = 0.023 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%) Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855 E VH L K A E A+ E+++ +E +G +AEAE V L E Sbjct: 1137 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907 + P ++ + +G ++ A+ L L+T G QG E+ + A+E Sbjct: 1195 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1253 Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 A L L A+L++ E + A+ D +E L+ D +R Sbjct: 1254 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1313 Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008 E ++ +A+L + + E + + R L + +A + Q+ Sbjct: 1314 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373 Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 ++ L +E L +E E V E + + I EL L + + E Sbjct: 1374 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1433 Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120 + +K ++S +E E Q +K +ET R EEE + Sbjct: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1490 Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180 + + E A VEA+ EK + + + Sbjct: 1491 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1522 Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 EA++ + + +EE+ RE A+ K +++ + + EAE K + E Sbjct: 1523 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1582 Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293 + + EE + LE +GG + L+ A AEE + +EEA + Sbjct: 1583 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639 Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353 ++E ++ E E +E + E + Q A+E L E AE Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1688 Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404 + R+V ETA+ E + +K +SF++ + Q+E V A + Sbjct: 1689 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1746 Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464 E A+ E A E + AL L + EE ++ + A + Sbjct: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1801 Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497 ++E E R G + E +REL+ + L+ L Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1837 Score = 37.7 bits (86), Expect = 0.086 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%) Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512 SA+ TG K+ + + +L+D L+ + +D E+ E Sbjct: 4143 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4202 Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572 + + G D +MN I P DD K DP E + + + + D G L+E Sbjct: 4203 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4260 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632 K++ KT+S +S R + D E + S E+ R+ ++ Sbjct: 4261 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4304 Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662 +L + E E E E+ I+ +D K M ID Sbjct: 4305 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4333 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 80.9 bits (198), Expect = 9e-15 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%) Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471 +T+K +EL+ KVR E E ++ + +E S S K + E + G L E Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783 Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531 + + + K +++ E+D + E E GE + + +A++ + Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1835 Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588 + E E+E + A D + +E ++++EE ++ AS S R Sbjct: 1836 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1888 Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645 D+ + + E ++ E A ++ EL + L +E E+E Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705 Q A+ E + +E + L E Q A L E EE + + + Sbjct: 1949 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2007 Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765 +ES Q++ LA A +E A + ++ +Q +Q+ Sbjct: 2008 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2045 Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825 TL++++++ D ++G+ EAA A EA ++A + A+ EE Sbjct: 2046 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2091 Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885 ER + A E R + ++ + + A ++A ++ E + Sbjct: 2092 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142 Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940 E +K EQ L +KA + E L L E H+ L E + EA E S Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202 Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993 V E + +E+ ++ R+ + + L +E A++ K+V R Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2260 Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053 LS EA R E ++ +LA E + E+M EA R E+L ++ Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2313 Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112 +LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE Sbjct: 2314 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2360 Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172 E K EM S A+ A +A +GE + + + T ++LE I Sbjct: 2361 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2416 Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232 + + ERL EA +++E+L E L ++E VQ E Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2461 Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292 L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E Sbjct: 2462 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520 Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346 + EE + E E R E +E + Q+ E + E L Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2579 Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400 E A E + S+ A KT+ N + AE E H D L K +A A Sbjct: 2580 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2639 Query: 1401 GKVVVEELARSGEEVPAAEEM 1421 G + EEL R + +E+ Sbjct: 2640 GILSAEELQRLAQGHTTVDEL 2660 Score = 72.0 bits (175), Expect = 4e-12 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%) Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470 K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1568 Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525 +E + L ++ E + + E E+ E + E+ K+NE + +Q Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628 Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585 + Q + EK+ E + + +AR K E + EL E + + + + + Sbjct: 1629 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682 Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645 +++ E ++ E R+ +EL+ + + + LE E+ Sbjct: 1683 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699 +A++E + E + +EK Q + AE L+E++ + + E+ K Sbjct: 1737 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792 Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759 + +L EE A+ + + + + A+G T E A E+ Sbjct: 1793 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841 Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819 ++L + + E++A QH+ ADI + + ++ + L + T Q Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1898 Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879 EE E + E+ A G AE E LG S+ +K+ L EA ++ Sbjct: 1899 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1951 Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939 L E ++ E E+ ++K++ A E AA + AAL E + + E + Sbjct: 1952 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2002 Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997 + E E + L ++ A KR E+A ++ +E ++ ++ E L Sbjct: 2003 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057 Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057 GEAEA+R E EE + E +E + V EAE ++ ++ A Sbjct: 2058 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2103 Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 + R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T Sbjct: 2104 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2157 Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168 ++ + ++ E LL E+ LK E+ L E Sbjct: 2158 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216 Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227 ++ L+ E R RD ++ R E +K+ + ++AA EA ++ Sbjct: 2217 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2274 Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284 A E L AE++ + + L+ AE +L+ Q+ +A+E ++ Sbjct: 2275 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2326 Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327 +E+ + EE + + TLE E + + + E + Q Sbjct: 2327 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386 Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376 + E +V V+ L + ++ AE RE +A E +EK + +A Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2445 Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407 +EE QQ++L+ +T A + + E Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2476 Score = 66.2 bits (160), Expect = 2e-10 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470 +S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 1989 Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529 E + +K + + + E +QE+ + + ++ + EK++ A Q Q Sbjct: 1990 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2045 Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587 L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++ Sbjct: 2046 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2105 Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643 + + ++ ++EA + +++A R +E +K +K L + +E E Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165 Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703 + + + + + +DE + + E TE Q ++ E V EE K K++ Sbjct: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2224 Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762 + E+ A + +DK L+E + +A A ++ E A + E Sbjct: 2225 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2280 Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822 Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A Sbjct: 2281 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2332 Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882 ++ E+ + G + EAE R+L + + E + L Sbjct: 2333 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2364 Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942 L V E +A + E+ ++ +A + E LH E AT E+ + + Sbjct: 2365 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2417 Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 +S+ +A E +E K + ++ L EE ++E + ET+ Sbjct: 2418 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2468 Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058 +Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R Sbjct: 2469 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2525 Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111 RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA Sbjct: 2526 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2585 Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171 S+ + V A++ N G D+L P EA P E S + Sbjct: 2586 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2625 Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208 LR++ +RL EA LS+ E + L +GH Sbjct: 2626 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2654 Score = 59.7 bits (143), Expect = 2e-08 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%) Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945 +E ++ +E ++ E+ LA AAL + A + A +E E + + Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381 Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003 EEA++D + E+ R+ E + + +R E + + EA Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1441 Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063 + Q E +L A E+ E ++ + EA R R+++ D ++ +R+A Sbjct: 1442 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1491 Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118 E S K ++E RE+ AL EE +L+AEE E + EV + + Sbjct: 1492 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1544 Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178 AE E + + ++ L E SL+E V + + E+ + ++ Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1597 Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 ER AR+ ++ E + N AL+ + + +LA EAE + + E Sbjct: 1598 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1652 Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294 G+AEE A + + LE + + G Q+ +A E ++ + E ++ Sbjct: 1653 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1707 Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354 + E++ L+ EA + + E + E + + A E T+E + Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1764 Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408 + E AG E A + +A +A +AEE+ Q+ A A +V+ E+L Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1817 Query: 1409 ARSGE 1413 A GE Sbjct: 1818 AAIGE 1822 Score = 51.2 bits (121), Expect = 8e-06 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%) Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091 EE AE R ++R+ + E++ A E+++ + K +ERE +++E Sbjct: 1323 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380 Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151 +EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++ Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1434 Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194 + + EAT G E L+ + A +E ++ + E R+ Sbjct: 1435 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493 Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239 EL+SR E A +E R ++ E L E E A +VQ + + Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553 Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297 AE A + A LE + + LR + + AE+ REEA E + Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613 Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357 L + ++ + E QK E A G+ E A +R Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1665 Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417 E LA E +++ +A + AE+E + E + +++ EELAR E A Sbjct: 1666 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1723 Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474 A + E +E + + +EE SE + + GR A E Sbjct: 1724 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1782 Query: 1475 RL-GLSREGERE 1485 RL L+ E +R+ Sbjct: 1783 RLRALAEEAKRQ 1794 Score = 39.7 bits (91), Expect = 0.023 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%) Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855 E VH L K A E A+ E+++ +E +G +AEAE V L E Sbjct: 978 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035 Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907 + P ++ + +G ++ A+ L L+T G QG E+ + A+E Sbjct: 1036 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1094 Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 A L L A+L++ E + A+ D +E L+ D +R Sbjct: 1095 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1154 Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008 E ++ +A+L + + E + + R L + +A + Q+ Sbjct: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214 Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 ++ L +E L +E E V E + + I EL L + + E Sbjct: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1274 Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120 + +K ++S +E E Q +K +ET R EEE + Sbjct: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1331 Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180 + + E A VEA+ EK + + + Sbjct: 1332 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1363 Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 EA++ + + +EE+ RE A+ K +++ + + EAE K + E Sbjct: 1364 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1423 Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293 + + EE + LE +GG + L+ A AEE + +EEA + Sbjct: 1424 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480 Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353 ++E ++ E E +E + E + Q A+E L E AE Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1529 Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404 + R+V ETA+ E + +K +SF++ + Q+E V A + Sbjct: 1530 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1587 Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464 E A+ E A E + AL L + EE ++ + A + Sbjct: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1642 Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497 ++E E R G + E +REL+ + L+ L Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1678 Score = 37.7 bits (86), Expect = 0.086 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%) Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512 SA+ TG K+ + + +L+D L+ + +D E+ E Sbjct: 3984 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4043 Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572 + + G D +MN I P DD K DP E + + + + D G L+E Sbjct: 4044 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4101 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632 K++ KT+S +S R + D E + S E+ R+ ++ Sbjct: 4102 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4145 Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662 +L + E E E E+ I+ +D K M ID Sbjct: 4146 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4174 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 80.9 bits (198), Expect = 9e-15 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%) Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471 +T+K +EL+ KVR E E ++ + +E S S K + E + G L E Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1791 Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531 + + + K +++ E+D + E E GE + + +A++ + Sbjct: 1792 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1843 Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588 + E E+E + A D + +E ++++EE ++ AS S R Sbjct: 1844 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1896 Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645 D+ + + E ++ E A ++ EL + L +E E+E Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705 Q A+ E + +E + L E Q A L E EE + + + Sbjct: 1957 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2015 Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765 +ES Q++ LA A +E A + ++ +Q +Q+ Sbjct: 2016 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2053 Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825 TL++++++ D ++G+ EAA A EA ++A + A+ EE Sbjct: 2054 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2099 Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885 ER + A E R + ++ + + A ++A ++ E + Sbjct: 2100 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150 Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940 E +K EQ L +KA + E L L E H+ L E + EA E S Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210 Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993 V E + +E+ ++ R+ + + L +E A++ K+V R Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2268 Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053 LS EA R E ++ +LA E + E+M EA R E+L ++ Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2321 Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112 +LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE Sbjct: 2322 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2368 Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172 E K EM S A+ A +A +GE + + + T ++LE I Sbjct: 2369 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2424 Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232 + + ERL EA +++E+L E L ++E VQ E Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2469 Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292 L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E Sbjct: 2470 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528 Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346 + EE + E E R E +E + Q+ E + E L Sbjct: 2529 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2587 Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400 E A E + S+ A KT+ N + AE E H D L K +A A Sbjct: 2588 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2647 Query: 1401 GKVVVEELARSGEEVPAAEEM 1421 G + EEL R + +E+ Sbjct: 2648 GILSAEELQRLAQGHTTVDEL 2668 Score = 72.0 bits (175), Expect = 4e-12 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%) Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470 K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E Sbjct: 1517 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1576 Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525 +E + L ++ E + + E E+ E + E+ K+NE + +Q Sbjct: 1577 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636 Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585 + Q + EK+ E + + +AR K E + EL E + + + + + Sbjct: 1637 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690 Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645 +++ E ++ E R+ +EL+ + + + LE E+ Sbjct: 1691 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699 +A++E + E + +EK Q + AE L+E++ + + E+ K Sbjct: 1745 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800 Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759 + +L EE A+ + + + + A+G T E A E+ Sbjct: 1801 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849 Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819 ++L + + E++A QH+ ADI + + ++ + L + T Q Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1906 Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879 EE E + E+ A G AE E LG S+ +K+ L EA ++ Sbjct: 1907 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1959 Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939 L E ++ E E+ ++K++ A E AA + AAL E + + E + Sbjct: 1960 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2010 Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997 + E E + L ++ A KR E+A ++ +E ++ ++ E L Sbjct: 2011 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2065 Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057 GEAEA+R E EE + E +E + V EAE ++ ++ A Sbjct: 2066 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2111 Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 + R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T Sbjct: 2112 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2165 Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168 ++ + ++ E LL E+ LK E+ L E Sbjct: 2166 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2224 Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227 ++ L+ E R RD ++ R E +K+ + ++AA EA ++ Sbjct: 2225 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2282 Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284 A E L AE++ + + L+ AE +L+ Q+ +A+E ++ Sbjct: 2283 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2334 Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327 +E+ + EE + + TLE E + + + E + Q Sbjct: 2335 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394 Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376 + E +V V+ L + ++ AE RE +A E +EK + +A Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2453 Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407 +EE QQ++L+ +T A + + E Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2484 Score = 66.2 bits (160), Expect = 2e-10 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470 +S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 1997 Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529 E + +K + + + E +QE+ + + ++ + EK++ A Q Q Sbjct: 1998 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2053 Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587 L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++ Sbjct: 2054 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2113 Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643 + + ++ ++EA + +++A R +E +K +K L + +E E Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2173 Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703 + + + + + +DE + + E TE Q ++ E V EE K K++ Sbjct: 2174 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2232 Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762 + E+ A + +DK L+E + +A A ++ E A + E Sbjct: 2233 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2288 Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822 Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A Sbjct: 2289 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2340 Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882 ++ E+ + G + EAE R+L + + E + L Sbjct: 2341 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2372 Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942 L V E +A + E+ ++ +A + E LH E AT E+ + + Sbjct: 2373 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2425 Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 +S+ +A E +E K + ++ L EE ++E + ET+ Sbjct: 2426 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2476 Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058 +Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R Sbjct: 2477 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2533 Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111 RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA Sbjct: 2534 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2593 Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171 S+ + V A++ N G D+L P EA P E S + Sbjct: 2594 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2633 Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208 LR++ +RL EA LS+ E + L +GH Sbjct: 2634 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2662 Score = 59.7 bits (143), Expect = 2e-08 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%) Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945 +E ++ +E ++ E+ LA AAL + A + A +E E + + Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389 Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003 EEA++D + E+ R+ E + + +R E + + EA Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1449 Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063 + Q E +L A E+ E ++ + EA R R+++ D ++ +R+A Sbjct: 1450 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1499 Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118 E S K ++E RE+ AL EE +L+AEE E + EV + + Sbjct: 1500 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1552 Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178 AE E + + ++ L E SL+E V + + E+ + ++ Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1605 Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 ER AR+ ++ E + N AL+ + + +LA EAE + + E Sbjct: 1606 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1660 Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294 G+AEE A + + LE + + G Q+ +A E ++ + E ++ Sbjct: 1661 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1715 Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354 + E++ L+ EA + + E + E + + A E T+E + Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1772 Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408 + E AG E A + +A +A +AEE+ Q+ A A +V+ E+L Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1825 Query: 1409 ARSGE 1413 A GE Sbjct: 1826 AAIGE 1830 Score = 51.2 bits (121), Expect = 8e-06 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%) Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091 EE AE R ++R+ + E++ A E+++ + K +ERE +++E Sbjct: 1331 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388 Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151 +EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++ Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1442 Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194 + + EAT G E L+ + A +E ++ + E R+ Sbjct: 1443 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501 Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239 EL+SR E A +E R ++ E L E E A +VQ + + Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561 Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297 AE A + A LE + + LR + + AE+ REEA E + Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621 Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357 L + ++ + E QK E A G+ E A +R Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1673 Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417 E LA E +++ +A + AE+E + E + +++ EELAR E A Sbjct: 1674 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1731 Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474 A + E +E + + +EE SE + + GR A E Sbjct: 1732 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1790 Query: 1475 RL-GLSREGERE 1485 RL L+ E +R+ Sbjct: 1791 RLRALAEEAKRQ 1802 Score = 39.7 bits (91), Expect = 0.023 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%) Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855 E VH L K A E A+ E+++ +E +G +AEAE V L E Sbjct: 986 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043 Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907 + P ++ + +G ++ A+ L L+T G QG E+ + A+E Sbjct: 1044 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1102 Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 A L L A+L++ E + A+ D +E L+ D +R Sbjct: 1103 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1162 Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008 E ++ +A+L + + E + + R L + +A + Q+ Sbjct: 1163 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1222 Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 ++ L +E L +E E V E + + I EL L + + E Sbjct: 1223 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1282 Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120 + +K ++S +E E Q +K +ET R EEE + Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1339 Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180 + + E A VEA+ EK + + + Sbjct: 1340 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1371 Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 EA++ + + +EE+ RE A+ K +++ + + EAE K + E Sbjct: 1372 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1431 Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293 + + EE + LE +GG + L+ A AEE + +EEA + Sbjct: 1432 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488 Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353 ++E ++ E E +E + E + Q A+E L E AE Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1537 Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404 + R+V ETA+ E + +K +SF++ + Q+E V A + Sbjct: 1538 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1595 Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464 E A+ E A E + AL L + EE ++ + A + Sbjct: 1596 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1650 Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497 ++E E R G + E +REL+ + L+ L Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1686 Score = 37.7 bits (86), Expect = 0.086 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%) Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512 SA+ TG K+ + + +L+D L+ + +D E+ E Sbjct: 3992 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4051 Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572 + + G D +MN I P DD K DP E + + + + D G L+E Sbjct: 4052 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4109 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632 K++ KT+S +S R + D E + S E+ R+ ++ Sbjct: 4110 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4153 Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662 +L + E E E E+ I+ +D K M ID Sbjct: 4154 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4182 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 80.9 bits (198), Expect = 9e-15 Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%) Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471 +T+K +EL+ KVR E E ++ + +E S S K + E + G L E Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1832 Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531 + + + K +++ E+D + E E GE + + +A++ + Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1884 Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588 + E E+E + A D + +E ++++EE ++ AS S R Sbjct: 1885 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1937 Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645 D+ + + E ++ E A ++ EL + L +E E+E Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705 Q A+ E + +E + L E Q A L E EE + + + Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2056 Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765 +ES Q++ LA A +E A + ++ +Q +Q+ Sbjct: 2057 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2094 Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825 TL++++++ D ++G+ EAA A EA ++A + A+ EE Sbjct: 2095 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2140 Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885 ER + A E R + ++ + + A ++A ++ E + Sbjct: 2141 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191 Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940 E +K EQ L +KA + E L L E H+ L E + EA E S Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251 Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993 V E + +E+ ++ R+ + + L +E A++ K+V R Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2309 Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053 LS EA R E ++ +LA E + E+M EA R E+L ++ Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2362 Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112 +LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE Sbjct: 2363 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2409 Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172 E K EM S A+ A +A +GE + + + T ++LE I Sbjct: 2410 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2465 Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232 + + ERL EA +++E+L E L ++E VQ E Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2510 Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292 L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569 Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346 + EE + E E R E +E + Q+ E + E L Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2628 Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400 E A E + S+ A KT+ N + AE E H D L K +A A Sbjct: 2629 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2688 Query: 1401 GKVVVEELARSGEEVPAAEEM 1421 G + EEL R + +E+ Sbjct: 2689 GILSAEELQRLAQGHTTVDEL 2709 Score = 72.0 bits (175), Expect = 4e-12 Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%) Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470 K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E Sbjct: 1558 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1617 Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525 +E + L ++ E + + E E+ E + E+ K+NE + +Q Sbjct: 1618 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677 Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585 + Q + EK+ E + + +AR K E + EL E + + + + + Sbjct: 1678 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731 Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645 +++ E ++ E R+ +EL+ + + + LE E+ Sbjct: 1732 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785 Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699 +A++E + E + +EK Q + AE L+E++ + + E+ K Sbjct: 1786 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841 Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759 + +L EE A+ + + + + A+G T E A E+ Sbjct: 1842 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890 Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819 ++L + + E++A QH+ ADI + + ++ + L + T Q Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1947 Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879 EE E + E+ A G AE E LG S+ +K+ L EA ++ Sbjct: 1948 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 2000 Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939 L E ++ E E+ ++K++ A E AA + AAL E + + E + Sbjct: 2001 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2051 Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997 + E E + L ++ A KR E+A ++ +E ++ ++ E L Sbjct: 2052 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2106 Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057 GEAEA+R E EE + E +E + V EAE ++ ++ A Sbjct: 2107 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2152 Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 + R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T Sbjct: 2153 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2206 Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168 ++ + ++ E LL E+ LK E+ L E Sbjct: 2207 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265 Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227 ++ L+ E R RD ++ R E +K+ + ++AA EA ++ Sbjct: 2266 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2323 Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284 A E L AE++ + + L+ AE +L+ Q+ +A+E ++ Sbjct: 2324 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2375 Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327 +E+ + EE + + TLE E + + + E + Q Sbjct: 2376 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435 Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376 + E +V V+ L + ++ AE RE +A E +EK + +A Sbjct: 2436 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2494 Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407 +EE QQ++L+ +T A + + E Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2525 Score = 66.2 bits (160), Expect = 2e-10 Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470 +S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2038 Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529 E + +K + + + E +QE+ + + ++ + EK++ A Q Q Sbjct: 2039 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2094 Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587 L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++ Sbjct: 2095 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2154 Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643 + + ++ ++EA + +++A R +E +K +K L + +E E Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2214 Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703 + + + + + +DE + + E TE Q ++ E V EE K K++ Sbjct: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2273 Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762 + E+ A + +DK L+E + +A A ++ E A + E Sbjct: 2274 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2329 Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822 Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A Sbjct: 2330 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2381 Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882 ++ E+ + G + EAE R+L + + E + L Sbjct: 2382 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2413 Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942 L V E +A + E+ ++ +A + E LH E AT E+ + + Sbjct: 2414 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2466 Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 +S+ +A E +E K + ++ L EE ++E + ET+ Sbjct: 2467 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2517 Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058 +Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R Sbjct: 2518 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2574 Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111 RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA Sbjct: 2575 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2634 Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171 S+ + V A++ N G D+L P EA P E S + Sbjct: 2635 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2674 Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208 LR++ +RL EA LS+ E + L +GH Sbjct: 2675 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2703 Score = 59.7 bits (143), Expect = 2e-08 Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%) Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945 +E ++ +E ++ E+ LA AAL + A + A +E E + + Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430 Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003 EEA++D + E+ R+ E + + +R E + + EA Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1490 Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063 + Q E +L A E+ E ++ + EA R R+++ D ++ +R+A Sbjct: 1491 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1540 Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118 E S K ++E RE+ AL EE +L+AEE E + EV + + Sbjct: 1541 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1593 Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178 AE E + + ++ L E SL+E V + + E+ + ++ Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1646 Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 ER AR+ ++ E + N AL+ + + +LA EAE + + E Sbjct: 1647 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1701 Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294 G+AEE A + + LE + + G Q+ +A E ++ + E ++ Sbjct: 1702 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1756 Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354 + E++ L+ EA + + E + E + + A E T+E + Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1813 Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408 + E AG E A + +A +A +AEE+ Q+ A A +V+ E+L Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1866 Query: 1409 ARSGE 1413 A GE Sbjct: 1867 AAIGE 1871 Score = 51.2 bits (121), Expect = 8e-06 Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%) Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091 EE AE R ++R+ + E++ A E+++ + K +ERE +++E Sbjct: 1372 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429 Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151 +EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++ Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1483 Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194 + + EAT G E L+ + A +E ++ + E R+ Sbjct: 1484 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542 Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239 EL+SR E A +E R ++ E L E E A +VQ + + Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602 Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297 AE A + A LE + + LR + + AE+ REEA E + Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662 Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357 L + ++ + E QK E A G+ E A +R Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1714 Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417 E LA E +++ +A + AE+E + E + +++ EELAR E A Sbjct: 1715 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1772 Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474 A + E +E + + +EE SE + + GR A E Sbjct: 1773 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1831 Query: 1475 RL-GLSREGERE 1485 RL L+ E +R+ Sbjct: 1832 RLRALAEEAKRQ 1843 Score = 39.7 bits (91), Expect = 0.023 Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%) Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855 E VH L K A E A+ E+++ +E +G +AEAE V L E Sbjct: 1027 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084 Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907 + P ++ + +G ++ A+ L L+T G QG E+ + A+E Sbjct: 1085 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1143 Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 A L L A+L++ E + A+ D +E L+ D +R Sbjct: 1144 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1203 Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008 E ++ +A+L + + E + + R L + +A + Q+ Sbjct: 1204 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1263 Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 ++ L +E L +E E V E + + I EL L + + E Sbjct: 1264 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1323 Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120 + +K ++S +E E Q +K +ET R EEE + Sbjct: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1380 Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180 + + E A VEA+ EK + + + Sbjct: 1381 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1412 Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 EA++ + + +EE+ RE A+ K +++ + + EAE K + E Sbjct: 1413 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1472 Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293 + + EE + LE +GG + L+ A AEE + +EEA + Sbjct: 1473 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529 Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353 ++E ++ E E +E + E + Q A+E L E AE Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1578 Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404 + R+V ETA+ E + +K +SF++ + Q+E V A + Sbjct: 1579 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1636 Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464 E A+ E A E + AL L + EE ++ + A + Sbjct: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1691 Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497 ++E E R G + E +REL+ + L+ L Sbjct: 1692 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1727 Score = 37.7 bits (86), Expect = 0.086 Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%) Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512 SA+ TG K+ + + +L+D L+ + +D E+ E Sbjct: 4033 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4092 Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572 + + G D +MN I P DD K DP E + + + + D G L+E Sbjct: 4093 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4150 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632 K++ KT+S +S R + D E + S E+ R+ ++ Sbjct: 4151 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4194 Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662 +L + E E E E+ I+ +D K M ID Sbjct: 4195 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4223 >gi|156104908 myosin heavy chain 6 [Homo sapiens] Length = 1939 Score = 78.6 bits (192), Expect = 4e-14 Identities = 203/982 (20%), Positives = 375/982 (38%), Gaps = 130/982 (13%) Query: 403 LDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462 L+ K R E E EL + K+ E + ++++ V + A E K Sbjct: 917 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 976 Query: 463 T-GLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521 L E + ++E+ +K ++ L++ + L +D +V+E+K S + + + Sbjct: 977 VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL-----DDLQVEEDKVNSLSKSKVKLEQ 1031 Query: 522 QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKD-ENDGCS-ESELEEDKQDMKT 579 Q++ + S +KK +D E+ ++++ D END E +L++ + D+ Sbjct: 1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDI-- 1089 Query: 580 ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEES 639 + +S EDE + L K +++ IEE Sbjct: 1090 --------NQQNSKIEDEQVLA---------------------LQLQKKLKENQARIEE- 1119 Query: 640 LEIEIEDQEITKADVETKPMPIDESFENVLKEGTEK-GTQEIAEGLSEKSGKHVSAEEKE 698 LE E+E + +A VE + E + + E G + +++K ++ Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1179 Query: 699 KDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKE 758 +++ L E+TA KK E G + L F + E + SN E Sbjct: 1180 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL-ELDDVTSNME 1238 Query: 759 SQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQ 818 Q+++ LEK ED+A ++R L ++++ + K E Sbjct: 1239 --QIIKAKANLEKVSRTLEDQANEYR----------VKLEEAQRSLNDFTTQRAKLQTEN 1286 Query: 819 PELAEEFTEKREIPPGIERGAEGAAE--AEGVRRLGEGGSDPIGQAAAK-------DAVG 869 ELA + EK + + RG + + R+L E G A A D + Sbjct: 1287 GELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR 1346 Query: 870 LSKDEAPEKQALMLTVL--------------ETD------------KAASEGEQGLEKAV 903 +E E +A + VL ETD K ++ Q E+AV Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAV 1406 Query: 904 LANEAAALNLEHL-HEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDT 962 A A +LE H + E + + A D + + I E E++ Sbjct: 1407 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD-KILAEWKQKYEES 1465 Query: 963 ASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEA 1022 S+ E +EA E K + + L F E + + ++S+ + + G K Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525 Query: 1023 F--------LCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTD 1074 L E +E + + EAEA+ E + +IL +L+ + + + ER L + D Sbjct: 1526 HELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER---KLAEKD 1582 Query: 1075 SEREEVTR-----ANALK---DEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126 E E+ R ++L+ D + + L+ ++ + E ++ E + N M ++A Sbjct: 1583 EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKK-KMEGDLNEMEIQLSHANRMAAEA 1641 Query: 1127 ENEAPVEASELSD-----NPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGER 1181 + + S L D + + D LKE + + + LE + A+ ++ R Sbjct: 1642 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 1701 Query: 1182 -LSEARDTEHKDREELSSRENRAL-KEGHRQDGEGALAAPEAEPA------GKVQAPEGL 1233 L+E E +R +L +N +L + + + + E E A + +A + + Sbjct: 1702 KLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAI 1761 Query: 1234 IPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDED 1293 A AEEL K+ D+ A LE + L+ + AE+ + K + + ++ Sbjct: 1762 TDAAMMAEEL-KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEAR 1820 Query: 1294 PEEEEDKECTLETEAMQDRNSE 1315 E E E EA Q RN+E Sbjct: 1821 VRELEG-----ELEAEQKRNAE 1837 Score = 42.0 bits (97), Expect = 0.005 Identities = 154/780 (19%), Positives = 287/780 (36%), Gaps = 104/780 (13%) Query: 398 IIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFS 457 ++A+ L KK ++R E+ E+ E + A KV K R + + EI E S Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1160 Query: 458 AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517 Q +E + Q++ D +E TL ++E +K + E G Sbjct: 1161 VQ------------IEMNKKREAEFQKMRRDLEEATL--QHEATAAALRKKHADSVAELG 1206 Query: 518 QADVQMNGIPQSPLDDKKDNLDPEKESETSS-QKAPDARDNVKDEN----DGCSESELEE 572 + + + Q L+ +K E + TS+ ++ A+ N++ + D +E ++ Sbjct: 1207 EQIDNLQRVKQK-LEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKL 1265 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQE-----LSEND 627 ++ T+ R+ + + E + ++EA T + E L E Sbjct: 1266 EEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEG 1325 Query: 628 KPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEK 687 K + + + +L+ D ++ + E + E L+ K E+A+ ++ Sbjct: 1326 KAKNA---LAHALQSARHDCDLLREQYEEETEAKAE-----LQRVLSKANSEVAQWRTKY 1377 Query: 688 SGKHVS-AEEKEKDKSKLW------EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGA 740 + EE E+ K KL EE+ V K + L + ++ + Sbjct: 1378 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE--------- 1428 Query: 741 PTMNFMVD------ETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGE 794 + MVD AA++ + + + + + +E+ E E+ Q + Sbjct: 1429 ---DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL-----S 1480 Query: 795 AALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEG 854 L+ A E+ E L EE ++ E + G + E E VR+ E Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE---QLGEGGKNVHELEKVRKQLEV 1537 Query: 855 GSDPIGQAAAKDAVGLSKDEAPEKQALM---LTVLETDKAASEGEQGLEKA------VLA 905 + A + L +E +A + E ++ +E ++ +E+A V+ Sbjct: 1538 EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVD 1597 Query: 906 NEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASID-------LEDTGP 958 + +L+ E LR E E + +S EA L+DT Sbjct: 1598 SLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI 1657 Query: 959 MEDTASKREDGSEEAILGGE--------EPAKERKEVMRTETRLSPFTGEAEASRMQVSE 1010 D A + D +E I E E + R V +TE E + +V Sbjct: 1658 QLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQL 1717 Query: 1011 GSPEEGSLAKEAFLCKEDV-----EGEEMVTEAEANREDDRKEILPKELDLARERRKA-- 1063 + SL + + D+ E EE V E N E+ K+ + +A E +K Sbjct: 1718 LHSQNTSLINQKKKMESDLTQLQSEVEEAVQECR-NAEEKAKKAITDAAMMAEELKKEQD 1776 Query: 1064 -----ERPKTSLRKTDSE-REEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 ER K ++ +T + + + A + + K+ QKL+A E E E+ AE++ A Sbjct: 1777 TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNA 1836 >gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] Length = 1020 Score = 75.9 bits (185), Expect = 3e-13 Identities = 138/616 (22%), Positives = 234/616 (37%), Gaps = 74/616 (12%) Query: 402 GLDKKPSLPKSRKEKSTEKGEELKKAEGK--VRKEREYVIPKRNEIKENKTSVSAKFSAQ 459 GL K PS+ K KS EK + ++K+E + + +E+ E+ E + + + + Sbjct: 425 GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK 484 Query: 460 EIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA 519 E + G +E EE T K P +E ++E + EE E K EK + A Sbjct: 485 EEEGGEEEEAEGGEEET-KSPPAEEAASPEKEAKSPVK-EEAKSPAEAKSPEKEEAKSPA 542 Query: 520 DVQMNGIPQSPLDDKKDNLDPEKESETSSQKAP-------DARDNVKDENDGCSESELEE 572 +V+ +SP ++ + K E K+P A+ K+E +E++ E Sbjct: 543 EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE 602 Query: 573 DKQD--MKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDE--SARRSSSQELSENDK 628 + + A S + P +++ + V E + +E S ++ S E E Sbjct: 603 KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS 662 Query: 629 PRKSHLPIEESLEIEIEDQEITKADV---ETKPMPIDESFENVLK---------EGTEKG 676 P K+ P++ + + + KA+ E P+ E ++ K + EK Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA 722 Query: 677 TQEIAEGLS--EKSGKHVSAEEKEKDKSKLWEES-TAQVKDKKAGLPGLEEGGK--DSLP 731 + E EK+ V E K +K+K E++ T VK +A P EE D P Sbjct: 723 KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP 782 Query: 732 LAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTL--EKKEAMEEDEAPQHRDADIV 789 +P + A + KE + +K E K ++E+E PQ Sbjct: 783 ----EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP 838 Query: 790 QGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIP---------PGIERGAE 840 K E E A T E+ + +E K+E P P +E+ E Sbjct: 839 PKKAE-----------EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887 Query: 841 GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900 EA+ + P + A V + +D P+++ + D A E + E Sbjct: 888 SKVEAK-KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946 Query: 901 KAVLANEAAALNLEHLHEVAALREAATSEEGEA-EGGVAVS------DVGESEEEASIDL 953 K EAA + E A E E +A E +S ++E+ +S D Sbjct: 947 K----KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002 Query: 954 EDTGP----MEDTASK 965 +D+ P ED A+K Sbjct: 1003 KDSKPPEKATEDKAAK 1018 Score = 72.0 bits (175), Expect = 4e-12 Identities = 145/716 (20%), Positives = 271/716 (37%), Gaps = 118/716 (16%) Query: 420 KGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKG 479 +GEE + G + +PK + + V ++ + ++ KE V VEE T + Sbjct: 407 EGEECRIGFGPIPFSLPEGLPKIPSVSTH-IKVKSEEKIKVVEKSEKETVI-VEEQTEET 464 Query: 480 KPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLD 539 + +EV E++++ + E +E+ E EE++ E EE +SP ++ + + Sbjct: 465 QVTEEVTEEEEKEAKEEEGKEE-EGGEEEEAEGGEEE----------TKSPPAEEAASPE 513 Query: 540 PEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESA 599 E +S + A ++ + S +E++ ++ K+ + ++S P + E E A Sbjct: 514 KEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK-AKSPAKEEAKSPPEAKSPEKEEA 572 Query: 600 VGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIED----QEITKADVE 655 E + A+ + +E P K+ P++E + E +E K+ E Sbjct: 573 KSPAEVKSPEKAKSPAKEEAKSP-AEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE 631 Query: 656 TK-PMPIDESFENVLKEGTEKGTQEIAEGLS-EKSGKHVSAEEKEKDKSKLWEESTAQVK 713 K P + K + + E E S EK+ V AE K +K+K ++ A+ Sbjct: 632 VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK-S 690 Query: 714 DKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKE 773 +KA P EE +P A + KE + +K + K+E Sbjct: 691 PEKAKSPVKEEAKSPE-------KAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE 743 Query: 774 AMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPP 833 A ++A A + K A + P K A P A++F EK + P Sbjct: 744 AKSPEKAKSPEKAKTLDVKSPEA---------KTPA---KEEARSP--ADKFPEKAKSP- 788 Query: 834 GIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAAS 893 ++ + +A ++ K+ + E P+K+ + V E +K Sbjct: 789 -VKEEVKSPEKA---------------KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP-- 830 Query: 894 EGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDL 953 EV +EE +A ++EE+ Sbjct: 831 -----------------------QEVKVKEPPKKAEEEKAPA------TPKTEEKKDSKK 861 Query: 954 EDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGS- 1012 E+ E K E+ E A+ +E E K+ + + P + ++++V E + Sbjct: 862 EEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK 921 Query: 1013 -PEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRK--AERPKTS 1069 E+ +AK+ +D + +E AE +KE P++ D E+ K E+PKT Sbjct: 922 PKEKTEVAKKE---PDDAKAKEPSKPAE------KKEAAPEKKDTKEEKAKKPEEKPKTE 972 Query: 1070 LRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSD 1125 + + D+ KE K KAE+ E + +++ PP + D Sbjct: 973 AKAKED------------DKTLSKEPSKPKAEKAEKSSS--TDQKDSKPPEKATED 1014 Score = 67.0 bits (162), Expect = 1e-10 Identities = 128/557 (22%), Positives = 206/557 (36%), Gaps = 69/557 (12%) Query: 817 EQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP 876 E+ ++ EE TE+ E E G E E G EGG + A++A +P Sbjct: 462 EETQVTEEVTEEEEKEAKEEEGKE---EEGGEEEEAEGGEEETKSPPAEEAA------SP 512 Query: 877 EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHL-----HEVAALREAATSEEG 931 EK+A V E K+ +E + EK + A + E E + EA + E+ Sbjct: 513 EKEAKS-PVKEEAKSPAEAKSP-EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKE 570 Query: 932 EAEGGVAVSDVGESE----EEASIDLEDTGPMEDTASKREDGSE--EAILGGEEPAKERK 985 EA+ V +++ EEA E P + + +E+ EA +E AK Sbjct: 571 EAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA 630 Query: 986 EVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMV---TEAEANR 1042 EV E SP EA++ S E S K K + + E +AEA Sbjct: 631 EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKS 690 Query: 1043 EDDRKEILPKEL-----------DLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091 + K + +E + A+ KA+ P KT + + + A E A Sbjct: 691 PEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA 750 Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDS-LK 1150 E+ + E + A+EE ++P ++ A++ E L ED+ Sbjct: 751 KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAP 810 Query: 1151 ETVVPIFEATPGFEKSLENITALRKEGGGERLSE------ARDTEHKDREELSSRENRAL 1204 E +P E K E ++ + ++ E + E KD ++ + + A Sbjct: 811 EKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAP 870 Query: 1205 KEGHRQDGEGALAAP----------EAEPAGKVQAPEGLIPATGQAEELA-AKDHDSCAG 1253 K + E A+ P EAE KV PE PA + +E A K+ A Sbjct: 871 KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAK 930 Query: 1254 LEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRN 1313 E +A A+E AEK +E A ++ +EE + E + + Sbjct: 931 KE--------------PDDAKAKEPSKPAEK-KEAAPEKKDTKEEKAKKPEEKPKTEAKA 975 Query: 1314 SEGDGDMEGEGNTQKNE 1330 E D + E + K E Sbjct: 976 KEDDKTLSKEPSKPKAE 992 Score = 63.9 bits (154), Expect = 1e-09 Identities = 110/588 (18%), Positives = 230/588 (39%), Gaps = 67/588 (11%) Query: 570 LEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKP 629 +EE ++ + + + + E + G E + +E+ + ++E + +K Sbjct: 457 VEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEET-KSPPAEEAASPEKE 515 Query: 630 RKSHLPIEESLEIEIE----DQEITKADVETK-PMPIDESFENVLKEGTEKGTQEIAEGL 684 KS P++E + E ++E K+ E K P + K E + E E Sbjct: 516 AKS--PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEA- 572 Query: 685 SEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMN 744 KS V + EK K +K +S A+ K + ++E K + A + Sbjct: 573 --KSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA 630 Query: 745 FMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQG-KGEAALWGEAGA 803 + A + KE + +K + EK+EA ++A A+ K ++ + EA Sbjct: 631 EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA-- 688 Query: 804 VHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAA 863 ++P +A P E+ + E+ A+ + E + E P+ + A Sbjct: 689 --KSPEKAKSPVKEEAKSPEK--------------AKSPVKEEA--KSPEKAKSPVKEEA 730 Query: 864 AKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALR 923 + PEK E + EKA +A L+++ + Sbjct: 731 ----------KTPEK---------AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAK 771 Query: 924 EAATS--EEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEP- 980 E A S ++ + V + +S E+A L++ + +++ + + E+P Sbjct: 772 EEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ 831 Query: 981 -AKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAE 1039 K ++ + E +P T + E + E +P++ + + KE + ++ E Sbjct: 832 EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVE 891 Query: 1040 ANRED--DRKEI------LPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091 A +E+ D+K++ P ++++ + + E+ + + ++ D + + A K E A Sbjct: 892 AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA 951 Query: 1092 FKE----EQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEAS 1135 ++ E+K K E + +TE +A+E+ K E +A +S Sbjct: 952 PEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS 999 Score = 55.8 bits (133), Expect = 3e-07 Identities = 154/712 (21%), Positives = 272/712 (38%), Gaps = 103/712 (14%) Query: 833 PGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAA 892 P RGA A+ + + L G P G A V S+ E + QAL D+ A Sbjct: 62 PSRFRGAGAASSTDSLDTLSNG---PEGCMVA---VATSRSEKEQLQAL------NDRFA 109 Query: 893 S--EGEQGLE--KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEE 948 + + LE L EAAAL + +A+ E E E G AV +G + + Sbjct: 110 GYIDKVRQLEAHNRSLEGEAAALRQQQAGR-SAMGELYEREVREMRG--AVLRLGAARGQ 166 Query: 949 ASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQV 1008 ++ E +ED A R+ +EA ++R+E L+ F EAEA+R+ + Sbjct: 167 LRLEQEHL--LEDIAHVRQRLDDEA--------RQREEAEAAARALARFAQEAEAARVDL 216 Query: 1009 SEGSPEEGSLAKEAFLCKEDVEGE--EMVTE------AEANREDDRKEILPKELDLARER 1060 + + +L +E + + E E++ + A+A + + ++ L ++ A Sbjct: 217 QKKAQ---ALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALRE 273 Query: 1061 RKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120 +A+ +++ T + EE R + +A K E TE R + + + Sbjct: 274 IRAQLEGHAVQST-LQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL 332 Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180 E ++ + SEL ED + + EA + L N K Sbjct: 333 EALKSTKDSLERQRSEL--------EDRHQADIASYQEAIQQLDAELRNT----KWEMAA 380 Query: 1181 RLSEARDTEH-KDREELSSRENRALKEGHR-QDGEGALAAPEAEPAGKVQAPEGLIPATG 1238 +L E +D + K ++ R L EG + G G + PEGL Sbjct: 381 QLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIP---------FSLPEGLPKIPS 431 Query: 1239 QAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEE 1298 + + K + ++ E +E I+ E+ E V E+ EEE Sbjct: 432 VSTHIKVKSEEK-----------------IKVVEKSEKETVIVEEQTEETQVTEEVTEEE 474 Query: 1299 DKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEERE 1358 +KE E + + EG + E EG ++ + + E E EE + Sbjct: 475 EKEAKEE----EGKEEEGGEEEEAEGGEEETKSPPAEEAASPE-----KEAKSPVKEEAK 525 Query: 1359 VLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAA 1418 A +++ E++ +A S ++V E + K+ K +E A+S EV + Sbjct: 526 SPAEAKSPEKE----EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSP 581 Query: 1419 EEMTVTYTTEA-GVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLG 1477 E+ EA + E+ S + +E + +E + E + EK + Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641 Query: 1478 LSREG---ERELSPESLQA----MATLPVKPDFTETREKQQHMVQGESETAD 1522 E E+ SPE +A A PVK + ++ EK + V+ E+++ + Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE-AKSPEKAKSPVKAEAKSPE 692 Score = 50.4 bits (119), Expect = 1e-05 Identities = 48/207 (23%), Positives = 87/207 (42%), Gaps = 15/207 (7%) Query: 409 LPKSRKEKSTEKGEE------LKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462 +PK + KS K EE +K+ K +E+ PK E K++K + K A + K Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873 Query: 463 TGLKEVVTAVEEMTSKGKPGQEVLED-------DQENTLKYEYEEDFEVDEEKQGEKSNE 515 K+ + SK + +E ED ++E K E +ED + E+ + K E Sbjct: 874 VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAK-KE 932 Query: 516 EGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQ 575 A + P + + D ++E ++ P K+++ S+ + + Sbjct: 933 PDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAE 992 Query: 576 DMKTASSTSSR-SHPYSSDSEDESAVG 601 + +SST + S P +ED++A G Sbjct: 993 KAEKSSSTDQKDSKPPEKATEDKAAKG 1019 Score = 48.1 bits (113), Expect = 6e-05 Identities = 106/478 (22%), Positives = 178/478 (37%), Gaps = 55/478 (11%) Query: 769 LEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEK 828 LE++ +E+ + R D + + EA EA RA A++ E A +K Sbjct: 169 LEQEHLLEDIAHVRQRLDDEARQREEA----------EAAARALARFAQEAEAARVDLQK 218 Query: 829 REIPPGIERGAEGAAEAEGVRRL-----GEGGSDPIGQAAAKDAVGLSKDEAPEKQALML 883 + E G E V L G G + QA +DA+ A Sbjct: 219 KAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSA-------- 270 Query: 884 TVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALR-EAATSEEGEAEGGVAVSDV 942 L +A EG ++ + + E + L+ L E A + +A S + E Sbjct: 271 --LREIRAQLEGH-AVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQA 327 Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 +E EA +D+ +E S+ ED + I A ++ + + + L E Sbjct: 328 RTTELEALKSTKDS--LERQRSELEDRHQADI------ASYQEAIQQLDAELRNTKWEMA 379 Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----------VTEAEANREDDRKEILPK 1052 A + + + +L E ++ +EGEE + E I K Sbjct: 380 AQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVK 439 Query: 1053 ELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE 1112 + + K+E+ +T + + +E +VT ++E KEE+ + E GE E E Sbjct: 440 SEEKIKVVEKSEK-ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498 Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172 EETK+PP E + E EA E + +P +E +P KS E + Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA------KSPAEVKSPEKAKS 552 Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAP 1230 KE E S + E S E ++ ++ E A + EA+ K ++P Sbjct: 553 PAKE---EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP 607 Score = 47.4 bits (111), Expect = 1e-04 Identities = 70/320 (21%), Positives = 128/320 (40%), Gaps = 44/320 (13%) Query: 405 KKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG 464 +K P + KS EK + +KA+ K E P + E + S + KF ++ K+ Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR----SPADKFP-EKAKSP 788 Query: 465 LKEVVTAVEEMTSKGK-----PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA 519 +KE V + E+ S K P +E+ + ++ + E E+ EV ++ +K+ EE Sbjct: 789 VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE--- 845 Query: 520 DVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDEN--DGCSESELE---EDK 574 ++P K + K+ E ++AP + K E + ES++E E+ Sbjct: 846 --------KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897 Query: 575 QDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHL 634 +D K + + ED E D A+ S + P K Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDT 957 Query: 635 PIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSA 694 E++ + E + + KA KE + ++E ++ +EK+ K S Sbjct: 958 KEEKAKKPEEKPKTEAKA-----------------KEDDKTLSKEPSKPKAEKAEKSSST 1000 Query: 695 EEKE-KDKSKLWEESTAQVK 713 ++K+ K K E+ A+ K Sbjct: 1001 DQKDSKPPEKATEDKAAKGK 1020 >gi|87299628 biorientation of chromosomes in cell division 1-like [Homo sapiens] Length = 3051 Score = 73.9 bits (180), Expect = 1e-12 Identities = 164/823 (19%), Positives = 318/823 (38%), Gaps = 141/823 (17%) Query: 413 RKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAV 472 +K KST+KGE KK + + ER+ KE K KF + ++V Sbjct: 314 QKNKSTDKGE--KKPDSNEKGERK---------KEKKEKTEKKFDHSKKSEDTQKV---K 359 Query: 473 EEMTSKGKPGQEVLEDDQENTLKYE----YEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ 528 +E +K K + + ++N+ K + +EDF + + S+ +G D+ ++ + Sbjct: 360 DEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLID------SDVDGLTDITVSSVHT 413 Query: 529 SPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSH 588 S L ++ D E+E TS D E E+ D ++ + T ++ Sbjct: 414 SDLSSFEE--DTEEEVVTS---------------DSMEEGEITSDDEEKNKQNKTKTQ-- 454 Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQE 648 +SDS + R A+ S S S + ++ R+S I + E + ++ Sbjct: 455 --TSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQS---IAKEKEERLLRRQ 509 Query: 649 ITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKS-KLWEE 707 I + +E K E ++ +G + + ++ E S KS + +A KE K K+ E+ Sbjct: 510 INREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEES-STKSLEPKAARIKEVLKERKVLEK 568 Query: 708 STAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTY 767 A K +K +EE NS K+ Q Sbjct: 569 KVALSKKRKKDSRNVEE-----------------------------NSKKKQQYEEDSKE 599 Query: 768 TLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTE 827 TL+ E E+++ ++ V K E + A + E+ L + +L E + Sbjct: 600 TLKTSEHCEKEKISSSKELKHVHAKSEPS--KPARRLSES-LHVVDENKNESKLEREH-K 655 Query: 828 KREIPPGIERGAEGAAEAEGVRRLGEGG----SDPIGQ-AAAKDAVGLSKD--EAPEKQA 880 +R P I G + + V+R E +P Q + K+ L KD E P ++ Sbjct: 656 RRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKS 715 Query: 881 LMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEE-GEAEGGVAV 939 L+ +++ K E E+ L+++H ++ + + E +E G+ V Sbjct: 716 LLKKEVKSSKEKPEREK-------TPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKV 768 Query: 940 SD-VGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGE-EPAKE---------RKEVM 988 + + + ++ + +D + SK + + ++LG + +P E RKE Sbjct: 769 EENIQKQSQQTKLSSDD---KTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENN 825 Query: 989 RTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKE 1048 + E RLS +AE + S+ ++ SL + G + +E+ ED Sbjct: 826 KKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQ-------HGITLQRRSESYSED---- 874 Query: 1049 ILPKELDLARERRKAE-RPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETET 1107 + D+ + +P+ + K + + + + + +++K E E + Sbjct: 875 ----KCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQE 930 Query: 1108 EVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKET-VVPIFEATPGFEKS 1166 + T P E ++ + S++ D P +ET V P+ E S Sbjct: 931 GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKP-------FEETGVEPVLETASSSAHS 983 Query: 1167 LENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHR 1209 + ++ R +L A++ D++ S+R R L +GH+ Sbjct: 984 TQKDSSHR-----AKLPLAKEKYKSDKDSTSTRLERKLSDGHK 1021 Score = 53.1 bits (126), Expect = 2e-06 Identities = 232/1158 (20%), Positives = 413/1158 (35%), Gaps = 195/1158 (16%) Query: 403 LDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKF-SAQEI 461 L+KK +L K RK+ S + E +K+++Y + +K ++ K S++E+ Sbjct: 566 LEKKVALSKKRKKDS-------RNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKEL 618 Query: 462 KTGLKEVVTAVEEMTSKGKPGQEVLE-----DDQENTLKYEYEEDFE-----VDEEKQGE 511 K V + KP + + E D+ +N K E E + E Q E Sbjct: 619 K--------HVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEE 670 Query: 512 KSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELE 571 + + V+ + I +K L EK + + P + +K E +S E Sbjct: 671 TDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKE----VKSSKE 726 Query: 572 EDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDS---STDESARRSSSQ-ELSEND 627 + +++ + S H Y D ++ + E H+ +E+ ++ S Q +LS +D Sbjct: 727 KPEREKTPSEDKLSVKHKYKGDCMHKTG-DETELHSSEKGLKVEENIQKQSQQTKLSSDD 785 Query: 628 K-PRKSHLPIEESLEIEIEDQEITKADVETKPMP--IDESFENVLKEGTEKGTQEIAEGL 684 K RKS E L + +D KP+ I ++ ENV KE +K + AE Sbjct: 786 KTERKSKHRNERKLSVLGKD---------GKPVSEYIIKTDENVRKENNKKERRLSAE-- 834 Query: 685 SEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSL-PLAYVLALGAPTM 743 + K + KS+ +S Q KDSL + + L + Sbjct: 835 ----------KTKAEHKSRRSSDSKIQ---------------KDSLGSKQHGITLQRRSE 869 Query: 744 NFMVD----ETAAINSNKESQQLVQK-----TYTLEKKEAMEEDEAPQHRDADIVQGKGE 794 ++ D ++ ++SN + +++V K LE+K ++ Q + +V Sbjct: 870 SYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVV----- 924 Query: 795 AALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEG 854 E A +A P ++ + EE +++ +E + E Sbjct: 925 -----ETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVED-----------KPFEET 968 Query: 855 GSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLE 914 G +P+ + A+ A KD + +A + E K+ + + L++ + +L+ Sbjct: 969 GVEPVLETASSSAHSTQKDSS--HRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLK 1026 Query: 915 HLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAI 974 H + ++ S++ + + +V S E+A ++ ME S+R + Sbjct: 1027 HSSKDIKKKDENKSDDKDGK------EVDSSHEKAR---GNSSLMEKKLSRRLCENRRGS 1077 Query: 975 LGGEEPAKERKEVMRTETRLS--------------------PFTGEAEASRMQVSEGSPE 1014 L E E K T + S P ++E V E S Sbjct: 1078 LSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKT 1137 Query: 1015 EGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAER---PKTSLR 1071 + + + ++D++ E M + A + D + K R ++ Sbjct: 1138 QDNRNNNS---QQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSE 1194 Query: 1072 KTDSEREEVTRANALKDE-DAFKEEQKLKAEEGETETEVRAE-----------EETKAPP 1119 K R +T+ ++ +K G TE + +E E + Sbjct: 1195 KHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQK 1254 Query: 1120 NEMGSDAENEAPVEASELSDNPGLLGEDSLKE-TVVPIFEA-TPGFEKSLENITALRKEG 1177 N + AE + L + L SL TVVP+ E+ P + T L EG Sbjct: 1255 NLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVL--EG 1312 Query: 1178 GGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPAT 1237 S A D + L+ RE+ LK ++G PA + IP Sbjct: 1313 STASTSPA-DHSALPNQSLTVRESEVLKTSDSKEGGEGFTVD--TPAKASITSKRHIPEA 1369 Query: 1238 GQAEELAAKDHDSCAGLEGRAEG----------QGG-VDVVLRTQEAVAEED-----PIM 1281 QA L K L + G +GG VD+ + + AE + Sbjct: 1370 HQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKAT 1429 Query: 1282 AEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEG---DGDMEGEGNTQKNE-GMGGGRV 1337 E +++ + D + E ET ++ + S G D ++ E + +E G Sbjct: 1430 VENGKKDGIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSG 1489 Query: 1338 VAVEVLH-GGGETAETAA----EEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDE 1392 A VLH G+T + A E+ +A S ++K + + +Q E Sbjct: 1490 SAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSE 1549 Query: 1393 L----VGKTAAAGKVVVEELARSGEEVPA-AEEMTVTYTTEAG--VGTPGALERKTSGLG 1445 + A G ++ + V A A E TV E G V T G E +T Sbjct: 1550 VALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESET--FL 1607 Query: 1446 QEQEEGSEGQEAATGSGD 1463 +EG G+ A S D Sbjct: 1608 TSTKEGESGECAVAESED 1625 Score = 49.3 bits (116), Expect = 3e-05 Identities = 207/1084 (19%), Positives = 371/1084 (34%), Gaps = 145/1084 (13%) Query: 402 GLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKE--REYVIPKRNEIKENKTSVSAKFSAQ 459 G K+ + PK KEK+TE+ + K+ + KV + E + E + + K S+ Sbjct: 931 GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSH 990 Query: 460 EIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA 519 K L + ++ ++ + +++ + + +LK+ ++ + DE K +K +E + Sbjct: 991 RAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDS 1050 Query: 520 DVQMNGIPQSPLDDK-KDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMK 578 + S ++ K L + S + A + S S L+ K+ Sbjct: 1051 SHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKK--- 1107 Query: 579 TASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQEL-SENDKPRKSHLPIE 637 S P E +S G S T ++ +S Q++ SEN K + S + Sbjct: 1108 ---SGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQK 1164 Query: 638 ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697 + L D + T K G +GT G++ S KH A+ + Sbjct: 1165 DELRTCTADSKATAP---------------AYKPG--RGT-----GVNSNSEKH--ADHR 1200 Query: 698 EKDKSKLWEESTAQVKDKKAGLP---GLEEGGKDSLPLAYVLALGAPTMNFMV------- 747 K+ +S + P G E DS + + L AP+ N V Sbjct: 1201 STLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDS-ETVHRMLLSAPSENDRVQKNLKNT 1259 Query: 748 ---------DETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGK------ 792 D T ++N +S + + +E+ + D P +++G Sbjct: 1260 AAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSP 1319 Query: 793 -GEAALWGEAGAVHEAPLRAWKPTAEQPE-------LAEEFTEKREIPPGIERGAEGAAE 844 +AL ++ V E+ + + E E T KR IP + + Sbjct: 1320 ADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQ 1379 Query: 845 AEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVL 904 + + LG + I + G D A ++ L + E G + + Sbjct: 1380 GKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVENGKKDGIA 1439 Query: 905 ANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTAS 964 + LN E E L+ + + + +++ DV E + +D + Sbjct: 1440 VDHVVGLNTEKYAETVKLKHKRSPGKVK---DISI-DVERRNENSEVDTSAGSGSAPSVL 1495 Query: 965 KREDGSEEAILGGEEPAKERKEVMRTETRLSPFT-GEAEASRMQVSEGSPEEGSLAKEAF 1023 + +G E + G A++ TE + T +A + + +A Sbjct: 1496 HQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALPCT 1555 Query: 1024 LCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRA 1083 + D EG + T + N L + E + T + VT Sbjct: 1556 SIEAD-EGLIIGTHSRNN-----------PLHVGAEASEC----TVFAAAEEGGAVVTEG 1599 Query: 1084 NALKDEDAFKEEQKLKAEEGE---TETEVRAEE-------ETKAPPNEMGSDAENEAPVE 1133 A + + F K + E GE E+E RA + + +A N + ++ +++A Sbjct: 1600 FA--ESETFLTSTK-EGESGECAVAESEDRAADLLAVHAVKIEANVNSVVTEEKDDAVTS 1656 Query: 1134 ASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDR 1193 A G L DS I E T F +E+ A+ G R Sbjct: 1657 AGSEEKCDGSLSRDS------EIVEGTITFISEVESDGAVTSAGTEIRAGSI------SS 1704 Query: 1194 EELSSRENRALKEGHRQDGEGALAAPEAE----------PAGKVQAPEGLIPATGQAEEL 1243 EE+ + ++ G +++ EG + AE G E ++ G + Sbjct: 1705 EEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAG----V 1760 Query: 1244 AAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECT 1303 D+D+ G EG G V+ + E + + E+ E P E + Sbjct: 1761 VLGDNDAPPGTSASQEGDGSVN------DGTEGESAVTSTGITEDG--EGPASCTGSEDS 1812 Query: 1304 LETEAMQDRNSE-GDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAG 1362 E A+ + E G+ M+ +T EG V A G T+ A EE E G Sbjct: 1813 SEGFAISSESEENGESAMD---STVAKEGTNVPLVAAGPCDDEGIVTSTGAKEEDE--EG 1867 Query: 1363 SETAEEKTIANK---ASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAE 1419 + N+ AS+ + + EE E + G VV A +G + A Sbjct: 1868 EDVVTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNAN 1927 Query: 1420 EMTV 1423 E V Sbjct: 1928 ENNV 1931 Score = 47.0 bits (110), Expect = 1e-04 Identities = 120/641 (18%), Positives = 235/641 (36%), Gaps = 103/641 (16%) Query: 844 EAEGVRRLGEGGSDPIGQAAAKDAVGL-SKDEAPEKQALMLTVLETDKA-ASEGEQGLEK 901 EA R E + + A+K + D + +K+ + + +K+ A G +GLE Sbjct: 214 EASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLET 273 Query: 902 AVLANEAAAL--------NLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDL 953 A + E + L N H L +E + + +D GE + +++ Sbjct: 274 APKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKS-TDKGEKKPDSNEKG 332 Query: 954 EDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSP 1013 E ++ K+ D S+++ + K+ K+ E E +++ + EG+ Sbjct: 333 ERKKEKKEKTEKKFDHSKKS--EDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTK 390 Query: 1014 EEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT 1073 E+ SL DV+G +T + + D S + Sbjct: 391 EDFSLIDS------DVDGLTDITVSSVHTSD-----------------------LSSFEE 421 Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPP----------NEMG 1123 D+E E VT + + E +E+K K + +T+T +E +TK+ ++ Sbjct: 422 DTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYY 481 Query: 1124 SDAENEAPVE------ASELSDN--PGLLGEDSLKETVVPIFEATPGFE----------- 1164 SD+++E VE A E + + + L+E E T + Sbjct: 482 SDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDL 541 Query: 1165 -----KSLENITALRKEGGGERLSEARDTEHKDREELSSR---ENRALKEGHRQDGEGAL 1216 KSLE A KE ER + + + SR EN K+ + +D + L Sbjct: 542 EESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETL 601 Query: 1217 AAPEAEPAGKVQAPEGL----------IPATGQAEELAAKDHD-SCAGLEGRAEGQGGVD 1265 E K+ + + L PA +E L D + + + LE + + Sbjct: 602 KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTP 661 Query: 1266 VVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE-----------EDKECTLETEAMQDRNS 1314 V++ + + + + R E E+P+++ +D T +++ + Sbjct: 662 VIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEV 721 Query: 1315 EGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANK 1374 + + T + + + +H G+ E + E+ L E ++++ K Sbjct: 722 KSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKG-LKVEENIQKQSQQTK 780 Query: 1375 ASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEV 1415 SS D E ++ H+ + + GK V E + ++ E V Sbjct: 781 LSS-DDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENV 820 Score = 44.3 bits (103), Expect = 0.001 Identities = 120/592 (20%), Positives = 221/592 (37%), Gaps = 82/592 (13%) Query: 950 SIDLEDTGPMEDTASKREDGSEEAILGGE----EPAKER-KEVMRTETRLSP-----FTG 999 S+ ED P TA S A G E PA R E +T P + Sbjct: 2468 SLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLA 2527 Query: 1000 EAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEE--------MVTEAEANREDDRKEILP 1051 ++ + P +G++A+ +FL E E+ +T E+ I P Sbjct: 2528 AVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTKCITGQESKIAPSHTMIPP 2587 Query: 1052 KELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111 +A K E+ T K D + +A+A K D +K EEG+ V + Sbjct: 2588 ATYSVALLAPKCEQDLTI--KNDYSGKWTDQASAEKTGDD-NSTRKSFPEEGDIMVTVSS 2644 Query: 1112 EEET------KAPPNEMG-----SDAENEAPVEASELSDNPGLLGEDSL---KETVVPIF 1157 EE ++P N +G ++ + EA V + E + L +SL K + + Sbjct: 2645 EENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAEL 2704 Query: 1158 EATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSS--RENRALKEGHRQDGEGA 1215 + P N+ E G R +E +E ++ E+SS ++N GH Sbjct: 2705 QREPLLVNESLNV-----ENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGH------- 2752 Query: 1216 LAAPEAEPAGKVQAPEGLIPATGQAEE-LAAKDH--DSCAGLEGRAEGQGGVDVVLRTQE 1272 + EA+P +V+ E +P + + L+++D D+ L+ R E Q Sbjct: 2753 --SVEADPK-EVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIE---------TAQR 2800 Query: 1273 AVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNE-- 1330 E +P ++ ++E P+ + T + M++++ + GE Q ++ Sbjct: 2801 QCPETEPHDTKEENSRDLEELPKTSSETNSTT-SRVMEEKDEYSSSETTGEKPEQNDDDT 2859 Query: 1331 --GMGGGRVVAVEVLHGGG-----ETAETAAEEREVLAGSETAEEKTIANKASSF-SDVA 1382 + + ++ G ET ++ + G T E+ ++K +D + Sbjct: 2860 IKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDES 2919 Query: 1383 EEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA------AEEMTVTYTTEAGVGTPGA 1436 +ET + Q+ + K+V R + + AE + V P Sbjct: 2920 NKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDP-V 2978 Query: 1437 LERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSP 1488 ++K +E+EE E + + + + K +L S + +RE+SP Sbjct: 2979 EDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSP 3030 Score = 39.7 bits (91), Expect = 0.023 Identities = 204/1021 (19%), Positives = 362/1021 (35%), Gaps = 163/1021 (15%) Query: 435 REYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTL 494 RE + K ++ KE + A+ T + + A + GK G+ ++ + T Sbjct: 1333 RESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTG 1392 Query: 495 KYEYEEDFE-----VDEEKQGEKSNEEG------QADVQMNGIPQSPLDDKKDNLDPEKE 543 E+ VD K+ N E +A V+ NG D L+ EK Sbjct: 1393 VIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVE-NGKKDGIAVDHVVGLNTEKY 1451 Query: 544 SETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDR 603 +ET K + VKD + + + S S H + +ED A G R Sbjct: 1452 AETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDV-ATGPR 1510 Query: 604 EAHTDSSTDESARRSSSQELSE---------NDKPRKSHLPIEESLEIEIEDQEITKADV 654 A S + + LS + + R+S + + IE ++ I Sbjct: 1511 RAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALP-CTSIEADEGLIIGTHS 1569 Query: 655 ETKPMPID-ESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVK 713 P+ + E+ E + E+G + EG +E S +E E E + A+ + Sbjct: 1570 RNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESETFLTSTKEGESG-----ECAVAESE 1624 Query: 714 DKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKE 773 D+ A L LA+ A I +N S +K + Sbjct: 1625 DRAADL----------------LAVHA----------VKIEANVNSVVTEEKDDAVTSAG 1658 Query: 774 AMEEDEAPQHRDADIVQGKGEAALWGEA-GAVHEA--PLRAWKPTAEQPELAE----EFT 826 + E+ + RD++IV+G E+ GAV A +RA ++E+ + ++ Sbjct: 1659 SEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSISSEEVDGSQGNMMRMG 1718 Query: 827 EKREIPPGIE-RGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885 K+E + GAEG ++ + + G V D P A Sbjct: 1719 PKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVLGDNDAPPGTSASQ--- 1775 Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEA------EGGVAV 939 E D + ++G +G E AV + E A+ + S EG A E G + Sbjct: 1776 -EGDGSVNDGTEG-ESAVTSTGIT----EDGEGPASCTGSEDSSEGFAISSESEENGESA 1829 Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKER---KEVMRTETRLSP 996 D ++E ++ L GP +D G++E GE+ E+ T Sbjct: 1830 MDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEEDEEGEDVVTSTGRGNEIGHAST---- 1885 Query: 997 FTGEAEASR----MQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRK--EIL 1050 TG E S + +EG + G++ + + E + A N D E Sbjct: 1886 CTGLGEESEGVLICESAEGDSQIGTVVEHV-----EAEAGAAIMNANENNVDSMSGTEKG 1940 Query: 1051 PKELDLARERRKAERPKTSLRKTDSEREEVT---------RANALKDEDAFKEEQKLKAE 1101 K+ D+ + ++S+ S ++EVT +A D+ + Q K E Sbjct: 1941 SKDTDICSSAKGI--VESSVTSAVSGKDEVTPVPGGCEGPMTSAASDQ---SDSQLEKVE 1995 Query: 1102 E-----------------GET-ETEVRAEEETKAPPNEMGSDAENE------APVEASEL 1137 + GE E EV ++ ++ + ENE A + ++ Sbjct: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055 Query: 1138 SDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEA-RDTEHKDREEL 1196 ++ L G + + ++ T + + IT + EGG LS+A R E+ + + Sbjct: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDV--EGG---LSDALRTEENMEGTRV 2110 Query: 1197 SSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEEL--------AAKDH 1248 ++ E A + L A +E + E + +T EE K Sbjct: 2111 TTEEFEAPMPSAVSGDDSQLTASRSE-----EKDECAMISTSIGEEFELPISSATTIKCA 2165 Query: 1249 DSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEA 1308 +S + E + V++ T + E P+ + E+ +EE EC L + + Sbjct: 2166 ESLQPVAAAVEERATGPVLISTADF---EGPMPSAPPEAESPLASTSKEEKDECALISTS 2222 Query: 1309 MQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEE 1368 + + E + + G +NE G +E G G + ++ E+ E S +E Sbjct: 2223 IAE---ECEASVSGVVVESENERAG----TVMEEKDGSGIISTSSVEDCEGPVSSAVPQE 2275 Query: 1369 K 1369 + Sbjct: 2276 E 2276 Score = 36.6 bits (83), Expect = 0.19 Identities = 40/188 (21%), Positives = 82/188 (43%), Gaps = 15/188 (7%) Query: 412 SRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTA 471 S E + EK E+ K ++E + +I KR + K V ++ +VT Sbjct: 2843 SSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVT- 2901 Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531 VE+ S K +V++ D+ N E ++ SN++G+ + + + + Sbjct: 2902 VEQSPSSSK--LKVMQTDESNK---------ETANLQERSISNDDGEEKI-VTSVRRRGR 2949 Query: 532 DDKKDNL--DPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHP 589 K+ D + SE ++ D V+D+ + S+ E EE+++D + ++T S + Sbjct: 2950 KPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRS 3009 Query: 590 YSSDSEDE 597 + S+ + Sbjct: 3010 EAQRSKTQ 3017 Score = 35.8 bits (81), Expect = 0.33 Identities = 48/229 (20%), Positives = 92/229 (40%), Gaps = 8/229 (3%) Query: 410 PKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVV 469 P KE+++ EEL K + V+ +++E ++T+ + +E Sbjct: 2807 PHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEED 2866 Query: 470 TAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529 + +G+P + +E + +K + + D + +Q S++ + + Sbjct: 2867 QPIIIKRKRGRPRKYPVETTLK--MKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETA 2924 Query: 530 PLDDKK-DNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSH 588 L ++ N D E++ TS ++ +D SE E +Q K+ S Sbjct: 2925 NLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ--KSVSDPVEDKK 2982 Query: 589 PYSSDSEDESAVGDRE--AHTDSSTDESARRSSSQELSENDKPRKSHLP 635 SD E+E D A T S+T A+RS +Q LS + K ++ P Sbjct: 2983 EQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQ-LSPSIKRKREVSP 3030 Score = 33.1 bits (74), Expect = 2.1 Identities = 44/214 (20%), Positives = 88/214 (41%), Gaps = 23/214 (10%) Query: 907 EAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 E + +LE L + ++ + TS E + + S+ + E + D DT + Sbjct: 2812 EENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDD--------DTIKSQ 2863 Query: 967 EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCK 1026 E+ ++ I+ + + RK + T ++ + S+ + E+ + + + + Sbjct: 2864 EE--DQPIIIKRKRGRPRKYPVETTLKMK------DDSKTDTGIVTVEQSPSSSKLKVMQ 2915 Query: 1027 EDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTD---SEREEVTRA 1083 D +E E + +D E E + RR+ +PK SL +D S E R Sbjct: 2916 TDESNKETANLQERSISNDDGE----EKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ 2971 Query: 1084 NALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 ++ D K+EQ+ EE E E + + T++ Sbjct: 2972 KSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRS 3005 >gi|38176300 nestin [Homo sapiens] Length = 1621 Score = 73.2 bits (178), Expect = 2e-12 Identities = 252/1168 (21%), Positives = 433/1168 (37%), Gaps = 260/1168 (22%) Query: 415 EKSTEK--GEELKKAEGKVRKEREYVIPKRNE-----IKENKTSVSAKFSAQEIKTGLKE 467 EK T K GEE++++ + + + + N+ ++E+ ++ K +E K LK+ Sbjct: 542 EKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETL--KSLEKENKELLKD 599 Query: 468 VVT-------AVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQAD 520 V AV ++ GK + L+ Q+ + + ++ N+E + Sbjct: 600 VEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSS 659 Query: 521 VQMNGIPQSPLDDKKDNLDPEKESETSSQKA--PDARDN------VKDENDGCSESELEE 572 +Q N + L+ K+N +P + E ++A P ++N ++DEN S +E Sbjct: 660 LQENLESLTALE--KENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKE 717 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVG--DREAHTDSSTDESARRSSSQELSENDKPR 630 +++ +KT + ED+S V + E H + E + + + L + + R Sbjct: 718 NQEPLKTL------------EEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQR 765 Query: 631 KSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGK 690 + L ++ + + ++ V+ +P+ +S + + E QE + L E+S + Sbjct: 766 RRSLGEQDQMTLRPPEK------VDLEPL---KSLDQEIARPLENENQEFLKSLKEESVE 816 Query: 691 HVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLE--EGGKDSLPLAYVLALGAPTMNFMVD 748 V + E E +S K AG LE + + PL + MN + Sbjct: 817 AVKSLETEILESL-----------KSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEK 865 Query: 749 ETA----AINSNKESQQLVQK----------TYTLEKKEAMEEDEAPQHRDADIVQGKGE 794 E ++ N+E+ +L+++ + LE + EE + R+ + + G+ Sbjct: 866 EIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGK 925 Query: 795 AALWGEAGAVHE--------APLRAWKPTAEQP-ELAEEFTEKREIPPGIERGAEGAAEA 845 ++ E A ++ W+ T E+ ELA+E PPG+ G E EA Sbjct: 926 GEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQES------PPGMA-GVENEDEA 978 Query: 846 EGVRRLGEG--GSDPI---GQAAAKDAV---GLSKDEAPE-KQALMLTVLETDKAASEGE 896 E R +G G + + G+ A + V G E+PE K+ L + K +EG Sbjct: 979 ELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGL 1038 Query: 897 QGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDT 956 Q E S++ A G A + E+ E D Sbjct: 1039 QDPE-------------------------GQSQQVGAPGLQAPQGLPEAIEPLVED---- 1069 Query: 957 GPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEG 1016 D A + S E +LG E P GE+ A +E P +G Sbjct: 1070 ----DVAPGGDQASPEVMLGSE-----------------PAMGESAAG----AEPGPGQG 1104 Query: 1017 --SLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTD 1074 L L +E+V E E++ E A+ + E P+ L + Sbjct: 1105 VGGLGDPGHLTREEV--------MEPPLEEESLE--------AKRVQGLEGPRKDLEEAG 1148 Query: 1075 SEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPP-NEMGSDAENEAPVE 1133 E + K D ++ ++ + EE E E AEE A GSDA + P+ Sbjct: 1149 GLGTEFSELPG-KSRDPWEPPREGR-EESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLG 1206 Query: 1134 ASELSDN-PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKD 1192 + E ++ P +L S T PI E PG + E + G + +EA + Sbjct: 1207 SEEAEEDVPPVLVSPS--PTYTPILEDAPGPQPQAEG--SQEASWGVQGRAEALGKVESE 1262 Query: 1193 REELSSRENRALKEGHRQDGEGAL-------------------------AAPEAEPAGKV 1227 +EEL S E + EG +++GE + +P +P G+ Sbjct: 1263 QEELGSGE---IPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQ 1319 Query: 1228 QAP-------EGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQ-EAVAEEDP 1279 + P EG PA +E L A + G EG E + G D L + E + E P Sbjct: 1320 RPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEG--EEECGRDSDLSEEFEDLGTEAP 1377 Query: 1280 IMAEKFRE--EAVDEDPEEEEDKECTLETEAMQDRNSEGDG-------DMEGEGNTQKNE 1330 + E E + + P+ L A DR+ E DG EGE + ++ Sbjct: 1378 FLPGVPGEVAEPLGQVPQ-------LLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGR 1430 Query: 1331 GMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQ 1390 G GR G G + GS A + + V+ W Sbjct: 1431 EPGAGR-------WGPGSSV-----------GSLQALSSSQRGEFLESDSVSVSVPW--D 1470 Query: 1391 DELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEE 1450 D L G A A K +E ++ E +EE + + E PG LE + E+ Sbjct: 1471 DSLRGAVAGAPKTALETESQDSAEPSGSEEESDPVSLEREDKVPGPLE-----IPSGMED 1525 Query: 1451 GSEGQEAATGSGDGRQETGAAEKFRLGL 1478 G + +G G G ++ G+ Sbjct: 1526 AGPGADIIGVNGQGPNLEGKSQHVNGGV 1553 Score = 54.3 bits (129), Expect = 9e-07 Identities = 163/750 (21%), Positives = 274/750 (36%), Gaps = 107/750 (14%) Query: 776 EEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPEL-AEEFTEKREIPPG 834 ++ E+ R I +G+GE +WG E + ++ Q E+ EE ++EI Sbjct: 480 KDGESGGSRVFSICRGEGEGQIWGL--VEKETAIEGKVVSSLQQEIWEEEDLNRKEI--- 534 Query: 835 IERGAEGAAEAEGVRRLGEGGSDPIG--QAAAKDAVGLSKDEAPEKQALMLTVLETDKAA 892 + ++ E E ++ LGE + + + + + + E P LE D Sbjct: 535 --QDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRS-------LEED--- 582 Query: 893 SEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASID 952 E + LEK N E L +V +R E EA G + + +++ S+ Sbjct: 583 LETLKSLEKE---------NKELLKDVEVVRPL----EKEAVGQLKPTGKEDTQTLQSLQ 629 Query: 953 LEDTGPMEDTASKRE------DGSEEAILGGEEP-------AKERKEVMRTETRLSPFTG 999 E+ M+ E ++E + +E KE +E +R SP G Sbjct: 630 KENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLR-----SPEVG 684 Query: 1000 EAEASRMQVSEGSPEEGSLA---KEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056 + EA R E SL KEAF E E + T E+D+ + P E + Sbjct: 685 DEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKT----LEEEDQSIVRPLETEN 740 Query: 1057 ARERRK-AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQK-----LKAEEGETETEVR 1110 + R E+ + +LR + E ++ R+ +D+ + +K LK+ + E + Sbjct: 741 HKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLE 800 Query: 1111 AE-EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLK--ETVVPIF---EATPGFE 1164 E +E E +A E E + G ++LK ET P++ E G Sbjct: 801 NENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAM 860 Query: 1165 KSLENITALRKEGGGERLSEARDTEHKDREELSS-----RENRALKEGHRQDGEGALAAP 1219 LE E R E +++E L S EN L+ D E Sbjct: 861 NPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLEN--LRSPEEVDKESQRNLE 918 Query: 1220 EAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDP 1279 E E GK + E L + +EL A+ Q D V + QE E P Sbjct: 919 EEENLGKGEYQESLRSLEEEGQELPQS-----------ADVQRWEDTVEKDQELAQESPP 967 Query: 1280 IMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVA 1339 MA E+ + + E++ E + N+ + + GEG+ + E +V Sbjct: 968 GMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVE 1027 Query: 1340 VEVLHGG--------GETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQD 1391 + GG G++ + A + G A E + + + D A E + Sbjct: 1028 GASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSE 1087 Query: 1392 ELVGKTAA----------AGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKT 1441 +G++AA G L R P EE ++ G+ P + Sbjct: 1088 PAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEA 1147 Query: 1442 SGLGQE-QEEGSEGQEAATGSGDGRQETGA 1470 GLG E E + ++ +GR+E+ A Sbjct: 1148 GGLGTEFSELPGKSRDPWEPPREGREESEA 1177 >gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sapiens] Length = 1782 Score = 72.0 bits (175), Expect = 4e-12 Identities = 186/947 (19%), Positives = 350/947 (36%), Gaps = 142/947 (14%) Query: 511 EKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL 570 ++ + G D + Q P D + + ES SS + P E C E L Sbjct: 532 KQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEP--------EEITCLEKGL 583 Query: 571 EEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARR-SSSQELSENDKP 629 E +QD + +S + + E + + RR S S + E DK Sbjct: 584 AEVQQDGEAEEGATS-----DGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV 638 Query: 630 RKSHLPIEESLEIEIEDQ-----EITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGL 684 + + L ES E++++ E K + + + S+E ++ G+ K Sbjct: 639 KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS 698 Query: 685 SEKSG-KHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLP---LAYVLALGA 740 E+ G K + + ++ D++ KDK+ G G+ G ++ P + G+ Sbjct: 699 DEEGGPKAMGGDHQKADEAG---------KDKETGTDGILAGSQEHDPGQGSSSPEQAGS 749 Query: 741 PTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGE 800 PT E +++ + ++LV P+ + ++ K E ++ G Sbjct: 750 PT------EGEGVSTWESFKRLV----------------TPRKKSKSKLEEKSEDSIAG- 786 Query: 801 AGAVHEAPLRAWKPTAEQPELAEEFTE-KREIPPGIERGAEGAAEAEGVRRLGEGGSDPI 859 +G H P +P E + K+ IP ++ +G E V G G++ Sbjct: 787 SGVEHSTP-------DTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANE- 838 Query: 860 GQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEV 919 + V LS+ +A E++ + E +A EQ +KA + L+ +H + Sbjct: 839 DDSDVPAVVPLSEYDAVEREKM-----EAQQAQKSAEQPEQKAA-TEVSKELSESQVHMM 892 Query: 920 AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME----DTASKREDGSEEAIL 975 AA G + + E + I T P+E + A E+ E ++ Sbjct: 893 AAA----------VADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI 942 Query: 976 GGEEPA----------KERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLC 1025 EEP + R + + +E L+P EA + EEG+ A A Sbjct: 943 AEEEPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEET 999 Query: 1026 KEDVEGEEMVTEAEANREDDR--KEILPKELDLARERRKAERPKTSLRKTDSEREEVTRA 1083 E V +T++ E+ +E+ D+ + R+ + ++ + E ++ Sbjct: 1000 TEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT 1059 Query: 1084 NALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGL 1143 ED + Q+ +AE R EE+ +A + + + + V+A E P Sbjct: 1060 GG--PEDVLQPVQRAEAE--------RPEEQAEA--SGLKKETDVVLKVDAQEAKTEPFT 1107 Query: 1144 LGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRA 1203 G+ + +T FE P +S+E+ SE T E L+ +++ Sbjct: 1108 QGK-VVGQTTPESFEKAPQVTESIES-------------SELVTT--CQAETLAGVKSQE 1151 Query: 1204 LKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGG 1263 + + ++E G + P T Q +E+ ++ ++ G Sbjct: 1152 MVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEA 1211 Query: 1264 VDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGE 1323 V + + A + E+ +E++ ED E DKE ++ET ++ + +EG + + Sbjct: 1212 EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK-TEGTQEADQY 1270 Query: 1324 GNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER---EVLAGSETAEEKTIANKASSFSD 1380 + + + V E L G +T T + E+ L G T E + + A Sbjct: 1271 ADEKTKD------VPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQS 1324 Query: 1381 VAEEETWHQQDELV-----GKTAAAGKVVVEELARSGEEVPAAEEMT 1422 A+ + E+V KT A V EE V +EE++ Sbjct: 1325 HAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVS 1371 Score = 63.5 bits (153), Expect = 1e-09 Identities = 219/1058 (20%), Positives = 379/1058 (35%), Gaps = 154/1058 (14%) Query: 539 DPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDE- 597 DP + + K + N + EL + D+ + +S E+E Sbjct: 43 DPAIAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEV 102 Query: 598 --SAVGDREAHTDSSTD---ESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKA 652 + VG R++ S D E A +S+ +D ++ IE+ E +E+T+ Sbjct: 103 IVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP 162 Query: 653 DVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQV 712 T+ D F+ V K K T + + +EK V +KD+ E A Sbjct: 163 ---TESQANDIGFKKVFKFVGFKFT--VKKDKTEKPDT-VQLLTVKKDEG----EGAAGA 212 Query: 713 KDKK-AGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDET-AAINSNKESQQLVQKTYTL- 769 D K L E K+S P + P +++ A I+ ES Q V++ Sbjct: 213 GDHKDPSLGAGEAASKESEPKQ---STEKPEETLKREQSHAEISPPAESGQAVEECKEEG 269 Query: 770 EKKEAMEEDEAPQHRDADIVQGKGEAA----LWGEAGAVHEAPLRAWKPTAEQPELAEEF 825 E+K+ E ++ + + + G G AG + R KP ++ E +E+ Sbjct: 270 EEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFR--KPKEDEVEASEK- 326 Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885 +K + P ++ +G AE + + P A + LS + EK L Sbjct: 327 -KKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEY--EKVELPS-- 381 Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLE-HLHEVAALREAATSEEGEAEGGVAVSDVGE 944 E + S+G + A LA E +E H EV A +T EE E V + Sbjct: 382 -EEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAG 440 Query: 945 SEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEP------------------------ 980 S + D P E +K +E + GE+P Sbjct: 441 SVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV 500 Query: 981 ----AKERKEV-------MRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDV 1029 ++ER +V + T T L +G+ + + G +E S Sbjct: 501 EMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGK----RGGGDEESGEHTQVPADSPD 556 Query: 1030 EGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDE 1089 EE E+ A+ ++ +EI E LA ++ E + + + +RE VT + K Sbjct: 557 SQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKM 616 Query: 1090 DAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASE-LSDNPGLLGEDS 1148 K+ + +E + + + + T + S+ + E E + P + S Sbjct: 617 VTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTS 676 Query: 1149 LK-ETVVPIFEATPGFEKSLENITALRKEGGGERLS---EARDTEHKDREELSSRENRAL 1204 + E ++ + + +K ++ +EGG + + + D KD+E + + Sbjct: 677 VSWEALICVGSS----KKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE--TGTDGILA 730 Query: 1205 KEGHRQDGEGALAAPEAEPAGKVQAPEG----------LIPATGQAEELAAKDHDSCAGL 1254 G+G + E AG EG + P +L K DS AG Sbjct: 731 GSQEHDPGQG---SSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAG- 786 Query: 1255 EGRAEGQGGVDVVLRTQEAVAEEDPIMAEKF------------REEAVDEDP----EEEE 1298 GV+ E EE + +KF +E+A ED E+ Sbjct: 787 -------SGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANED 839 Query: 1299 DKEC----------TLETEAMQDRNSEGDGDM-EGEGNTQKNEGMGGGRVVAVEVLHGGG 1347 D + +E E M+ + ++ + E + T+ ++ + +V + G Sbjct: 840 DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADG 899 Query: 1348 ETAETAAEEREV--LAGSETAEEKTIANKASSFSD-------VAEEETWHQQDELVGKTA 1398 A T EER ++ S T + + +A+ ++ +AEEE + L Sbjct: 900 TRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENRE 959 Query: 1399 AAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAA 1458 A G VV E + E V AAE G GA E + +E E Sbjct: 960 ARGDTVVSEAELTPEAVTAAET----------AGPLGAEEGTEASAAEETTEMVSAVSQL 1009 Query: 1459 TGSGDGRQETGAAEKFRLGLSREGERE-LSPESLQAMA 1495 T S D +E ++ G+ E+E + E LQA+A Sbjct: 1010 TDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVA 1047 Score = 32.7 bits (73), Expect = 2.8 Identities = 43/195 (22%), Positives = 72/195 (36%), Gaps = 21/195 (10%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG------ 464 K +E +E K E V ++I ++ + S K E++ Sbjct: 1596 KEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQ 1655 Query: 465 LKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMN 524 L+EVV EE G + V EDD L E+ E K+ EK ++ + Q + Sbjct: 1656 LEEVVLPSEE-EGGGAGTKSVPEDDGHALLAERIEKSLV--EPKEDEKGDDVDDPENQNS 1712 Query: 525 GIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTS 584 + + D L E +PD + E + E EL+E K ++ + + Sbjct: 1713 ALADT---DASGGLTKE---------SPDTNGPKQKEKEDAQEVELQEGKVHSESDKAIT 1760 Query: 585 SRSHPYSSDSEDESA 599 ++ E ESA Sbjct: 1761 PQAQEELQKQERESA 1775 >gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sapiens] Length = 1684 Score = 72.0 bits (175), Expect = 4e-12 Identities = 186/947 (19%), Positives = 350/947 (36%), Gaps = 142/947 (14%) Query: 511 EKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL 570 ++ + G D + Q P D + + ES SS + P E C E L Sbjct: 434 KQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEP--------EEITCLEKGL 485 Query: 571 EEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARR-SSSQELSENDKP 629 E +QD + +S + + E + + RR S S + E DK Sbjct: 486 AEVQQDGEAEEGATS-----DGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV 540 Query: 630 RKSHLPIEESLEIEIEDQ-----EITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGL 684 + + L ES E++++ E K + + + S+E ++ G+ K Sbjct: 541 KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS 600 Query: 685 SEKSG-KHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLP---LAYVLALGA 740 E+ G K + + ++ D++ KDK+ G G+ G ++ P + G+ Sbjct: 601 DEEGGPKAMGGDHQKADEAG---------KDKETGTDGILAGSQEHDPGQGSSSPEQAGS 651 Query: 741 PTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGE 800 PT E +++ + ++LV P+ + ++ K E ++ G Sbjct: 652 PT------EGEGVSTWESFKRLV----------------TPRKKSKSKLEEKSEDSIAG- 688 Query: 801 AGAVHEAPLRAWKPTAEQPELAEEFTE-KREIPPGIERGAEGAAEAEGVRRLGEGGSDPI 859 +G H P +P E + K+ IP ++ +G E V G G++ Sbjct: 689 SGVEHSTP-------DTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANE- 740 Query: 860 GQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEV 919 + V LS+ +A E++ + E +A EQ +KA + L+ +H + Sbjct: 741 DDSDVPAVVPLSEYDAVEREKM-----EAQQAQKSAEQPEQKAA-TEVSKELSESQVHMM 794 Query: 920 AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME----DTASKREDGSEEAIL 975 AA G + + E + I T P+E + A E+ E ++ Sbjct: 795 AAA----------VADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI 844 Query: 976 GGEEPA----------KERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLC 1025 EEP + R + + +E L+P EA + EEG+ A A Sbjct: 845 AEEEPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEET 901 Query: 1026 KEDVEGEEMVTEAEANREDDR--KEILPKELDLARERRKAERPKTSLRKTDSEREEVTRA 1083 E V +T++ E+ +E+ D+ + R+ + ++ + E ++ Sbjct: 902 TEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT 961 Query: 1084 NALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGL 1143 ED + Q+ +AE R EE+ +A + + + + V+A E P Sbjct: 962 GG--PEDVLQPVQRAEAE--------RPEEQAEA--SGLKKETDVVLKVDAQEAKTEPFT 1009 Query: 1144 LGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRA 1203 G+ + +T FE P +S+E+ SE T E L+ +++ Sbjct: 1010 QGK-VVGQTTPESFEKAPQVTESIES-------------SELVTT--CQAETLAGVKSQE 1053 Query: 1204 LKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGG 1263 + + ++E G + P T Q +E+ ++ ++ G Sbjct: 1054 MVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEA 1113 Query: 1264 VDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGE 1323 V + + A + E+ +E++ ED E DKE ++ET ++ + +EG + + Sbjct: 1114 EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK-TEGTQEADQY 1172 Query: 1324 GNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER---EVLAGSETAEEKTIANKASSFSD 1380 + + + V E L G +T T + E+ L G T E + + A Sbjct: 1173 ADEKTKD------VPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQS 1226 Query: 1381 VAEEETWHQQDELV-----GKTAAAGKVVVEELARSGEEVPAAEEMT 1422 A+ + E+V KT A V EE V +EE++ Sbjct: 1227 HAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVS 1273 Score = 60.5 bits (145), Expect = 1e-08 Identities = 205/985 (20%), Positives = 354/985 (35%), Gaps = 158/985 (16%) Query: 620 SQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQE 679 S+++S+ D ++ +I + QE T +E +P ES L + TE + Sbjct: 14 SEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQ--IPSSESNLEELTQPTESQAND 71 Query: 680 IAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQV----KDKKAGLPGL-----------EE 724 I +K K V + K K K + T Q+ KD+ G G E Sbjct: 72 IG---FKKVFKFVGFKFTVK-KDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEA 127 Query: 725 GGKDSLPLAYVLALGAPTMNFMVDET-AAINSNKESQQLVQKTYTL-EKKEAMEEDEAPQ 782 K+S P + P +++ A I+ ES Q V++ E+K+ E ++ + Sbjct: 128 ASKESEPKQ---STEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE 184 Query: 783 HRDADIVQGKGEAA----LWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERG 838 + + G G AG + R KP ++ E +E+ +K + P ++ Sbjct: 185 SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFR--KPKEDEVEASEK--KKEQEPEKVDTE 240 Query: 839 AEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQG 898 +G AE + + P A + LS + EK L E + S+G Sbjct: 241 EDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEY--EKVELPS---EEQVSGSQGPSE 295 Query: 899 LEKAVLANEAAALNLE-HLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTG 957 + A LA E +E H EV A +T EE E V + S + D Sbjct: 296 EKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAE 355 Query: 958 PMEDTASKREDGSEEAILGGEEP----------------------------AKERKEV-- 987 P E +K +E + GE+P ++ER +V Sbjct: 356 PQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQG 415 Query: 988 -----MRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANR 1042 + T T L +G+ + + G +E S EE E+ A+ Sbjct: 416 SPLKKLFTSTGLKKLSGKKQKGK----RGGGDEESGEHTQVPADSPDSQEEQKGESSASS 471 Query: 1043 EDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEE 1102 ++ +EI E LA ++ E + + + +RE VT + K K+ + +E Sbjct: 472 PEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSES 531 Query: 1103 GETETEVRAEEETKAPPNEMGSDAENEAPVEASE-LSDNPGLLGEDSLK-ETVVPIFEAT 1160 + + + + T + S+ + E E + P + S+ E ++ + + Sbjct: 532 DKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSS- 590 Query: 1161 PGFEKSLENITALRKEGGGERLS---EARDTEHKDREELSSRENRALKEGHRQDGEGALA 1217 +K ++ +EGG + + + D KD+E + + G+G Sbjct: 591 ---KKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE--TGTDGILAGSQEHDPGQG--- 642 Query: 1218 APEAEPAGKVQAPEG----------LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVV 1267 + E AG EG + P +L K DS AG GV+ Sbjct: 643 SSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAG--------SGVEHS 694 Query: 1268 LRTQEAVAEEDPIMAEKF------------REEAVDEDP----EEEEDKEC--------- 1302 E EE + +KF +E+A ED E+D + Sbjct: 695 TPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEY 754 Query: 1303 -TLETEAMQDRNSEGDGDM-EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREV- 1359 +E E M+ + ++ + E + T+ ++ + +V + G A T EER Sbjct: 755 DAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPS 814 Query: 1360 -LAGSETAEEKTIANKASSFSD-------VAEEETWHQQDELVGKTAAAGKVVVEELARS 1411 ++ S T + + +A+ ++ +AEEE + L A G VV E + Sbjct: 815 WISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELT 874 Query: 1412 GEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAA 1471 E V AAE G GA E + +E E T S D +E Sbjct: 875 PEAVTAAET----------AGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPV 924 Query: 1472 EKFRLGLSREGERE-LSPESLQAMA 1495 ++ G+ E+E + E LQA+A Sbjct: 925 QEVEGGVPDIEEQERRTQEVLQAVA 949 Score = 32.7 bits (73), Expect = 2.8 Identities = 43/195 (22%), Positives = 72/195 (36%), Gaps = 21/195 (10%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG------ 464 K +E +E K E V ++I ++ + S K E++ Sbjct: 1498 KEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQ 1557 Query: 465 LKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMN 524 L+EVV EE G + V EDD L E+ E K+ EK ++ + Q + Sbjct: 1558 LEEVVLPSEE-EGGGAGTKSVPEDDGHALLAERIEKSLV--EPKEDEKGDDVDDPENQNS 1614 Query: 525 GIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTS 584 + + D L E +PD + E + E EL+E K ++ + + Sbjct: 1615 ALADT---DASGGLTKE---------SPDTNGPKQKEKEDAQEVELQEGKVHSESDKAIT 1662 Query: 585 SRSHPYSSDSEDESA 599 ++ E ESA Sbjct: 1663 PQAQEELQKQERESA 1677 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 71.2 bits (173), Expect = 7e-12 Identities = 234/1210 (19%), Positives = 445/1210 (36%), Gaps = 180/1210 (14%) Query: 406 KPSLPKSRKEKSTE-KGEEL---KKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEI 461 KP L +R+E+ + K EEL K+ + KV E E + K ++ E K ++ + A+ Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET- 900 Query: 462 KTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521 E+ EEM ++ ++ LE+ + ++ E E +EE+ NE+ + Sbjct: 901 -----ELFAEAEEMRARLAAKKQELEE-----ILHDLESRVEEEEERNQILQNEKKKMQA 950 Query: 522 QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNV---KDENDG-------------- 564 + + + +++ + E T+ K + + +D+N Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010 Query: 565 CSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELS 624 CS S+L E+++ K + ++ SD E+ +E T +++ R+ + Sbjct: 1011 CS-SQLAEEEEKAKNLAKIRNKQEVMISDLEERLK---KEEKTRQELEKAKRKLDGETTD 1066 Query: 625 ENDKPRKSHLPIEE-SLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQ--EIA 681 D+ + I+E L++ +++E+ A + ++ N LK E Q E+ Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN--NALKVVRELQAQIAELQ 1124 Query: 682 EGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEE--GGKDSLPLAYVLALG 739 E + AE++++D S+ E +++D +E ++ AL Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184 Query: 740 APTMNFMVD--------ETAAINSNKESQQLVQKTYTLEK-KEAMEEDEAPQHRDADIVQ 790 T N TA +++ +Q + LEK K+ +E D + ++Q Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244 Query: 791 ---GKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEG 847 + E V E + + + ELAE+ ++ + + E AE +G Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE-EAEKKG 1303 Query: 848 VRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV--LETDKAA--------SEGEQ 897 ++ + S ++ +D L ++E +K L + LE +K + E + Sbjct: 1304 IKFAKDAASL---ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360 Query: 898 GLEKAVLANEAAALNL-----EHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASID 952 LEK VLA ++ + + L + +L EA +AE A+S E + A Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE---ALSQRLEEKALAYDK 1417 Query: 953 LEDTGPME----DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP-FTGEAEASRMQ 1007 LE T D + D + E+ K+ +++ E +S + E + + + Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477 Query: 1008 VSEGSPEEGSLAK---EAFLCKEDVEGEEMVTEAE-----ANREDDRKEILPKELDLARE 1059 E + SLA+ EA KE+ E + A+ ++++D K + E Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRAL 1537 Query: 1060 RRKAERPKTSLRKTDSEREEVTRANA----------------LKDEDAFKEEQKLKAEEG 1103 ++ E +T L + + E + A L+ D EE+K + Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597 Query: 1104 ETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGF 1163 E E E+E K + S + E ++ E D + + + + + Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657 Query: 1164 EKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEP 1223 ++ LE A R E + + + + E L +E A E R+ E Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE---------- 1707 Query: 1224 AGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEED----P 1279 + +ELA + +S +G + + ++ + E EE+ Sbjct: 1708 --------------QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1753 Query: 1280 IMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD----------MEGEGNTQKN 1329 ++ ++FR+ + D TL E +R++ D E + Q+ Sbjct: 1754 LLNDRFRKTTLQVD---------TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL 1804 Query: 1330 EGMGGGRVVA-VEVLHGG-GETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETW 1387 EG + A + L G+ E +E + A + +T F V E+E Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV-EDERR 1863 Query: 1388 H--QQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLG 1445 H Q E + K A K + +L + EE A A RK Sbjct: 1864 HADQYKEQMEKANARMKQLKRQLEEAEEEATRA----------------NASRRKLQREL 1907 Query: 1446 QEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTE 1505 + E +EG + R G F SR G R+L E A+L + D TE Sbjct: 1908 DDATEANEGLSREVSTLKNRLRRGGPISF--SSSRSGRRQLHLEG----ASLELSDDDTE 1961 Query: 1506 TREKQQHMVQ 1515 ++ + Q Sbjct: 1962 SKTSDVNETQ 1971 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 70.5 bits (171), Expect = 1e-11 Identities = 189/939 (20%), Positives = 345/939 (36%), Gaps = 94/939 (10%) Query: 405 KKPSLPKSRKEKSTE--KGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462 ++ L + ++E+ + K EE+++ E + R+E+ KR E +E + K QE + Sbjct: 586 RQQRLKREQEERLEQRLKREEVERLEQEERREQRL---KREEPEEERRQQLLKSEEQEER 642 Query: 463 TGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQ 522 ++ + ++ + + +E E+ E LK E+EE E E++ E+ E+ + ++ Sbjct: 643 R--QQQLRREQQERREQRLKREEEEERLEQRLKREHEE--ERREQELAEEEQEQARERIK 698 Query: 523 MNGIP--QSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL---EEDKQDM 577 IP Q L+ + D + S Q+ R ++E ESEL EE++ Sbjct: 699 SR-IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE-QEEKRRRRESELQWQEEERAHR 756 Query: 578 KTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIE 637 + R + +E++S G + E R E E + + LP E Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE--ERQQREQRFLPEE 814 Query: 638 ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697 E E Q + K + E E + + + QE +GL E + S E++ Sbjct: 815 EEKE-----QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869 Query: 698 EKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNK 757 +D+ W+ LEE K Y + A + Sbjct: 870 -RDQKWRWQ---------------LEEERKRRRHTLYA-------------KPALQEQLR 900 Query: 758 ESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAE 817 + QQL+Q+ E++E E+ + R Q + E L E E LR + Sbjct: 901 KEQQLLQE----EEEELQREEREKRRRQEQERQYREEEQLQQE----EEQLLREEREKRR 952 Query: 818 QPELAEEFTEKREIPPGIER--GAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEA 875 + E ++ + +++ E+ G E R + + Q ++ + + E Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE--EEQLLREEREK 1010 Query: 876 PEKQALMLTVLETDKAASEGEQGL----EKAVLANEAAALNLEHLHEVAALREAATSEEG 931 +Q + D+ E EQ L EK L E E+ E EE Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE--ELQQEEEQLLGEER 1068 Query: 932 EAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTE 991 E + EEE + E+ + + KR E EE ++ +E + E Sbjct: 1069 ETRRRQELERQYRKEEE--LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126 Query: 992 TRLSPFTGEAEASRMQVSEGSPEEGSLAKEA------------FLCKEDVEGEE--MVTE 1037 R E E + E EE L +E + +E+++ EE ++ E Sbjct: 1127 EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE 1186 Query: 1038 AEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQK 1097 + R +R+ +E +L R++RK R + E + NA++D + + ++ Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246 Query: 1098 LKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIF 1157 + ++++R + + + +G E + E E+ E Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ-K 1305 Query: 1158 EATPGFEKSLENITALRKEGGGERLSEARDTEHKDREE-LSSRENRALKEGHRQDGEGAL 1216 EA KS E LR+E +R + D + ++ E+ L RE + L+ RQ+ + Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR---RQERDRKF 1362 Query: 1217 AAPEA--EPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAV 1274 E + G+ E + E K+ E + + D R +E Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ 1422 Query: 1275 AEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRN 1313 KFREE +E E K E + Q+R+ Sbjct: 1423 LSRQE-RDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460 Score = 63.2 bits (152), Expect = 2e-09 Identities = 212/1074 (19%), Positives = 387/1074 (36%), Gaps = 160/1074 (14%) Query: 411 KSRKEKSTEKGEELKKAEGKV-RKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVV 469 + +E+ + E+L++ E ++ R+ERE +R + +E + K +E + +E Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREERE---KRRRQERERQYRKDKKLQQKEEQLLGEEPE 979 Query: 470 TAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQM--NGIP 527 + K +E L+ ++E L+ E E+ + E+Q K +E Q + Q+ Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039 Query: 528 QSPLDDKKDNLDPEKESETSSQKA----PDARDNVKDENDGCSESELEEDKQDMKTASST 583 + L +++ E+E + ++ + R + E E EL+++++ + Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099 Query: 584 SSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIE 643 R +E + E E RR QEL + + EE L E Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRR---QELERQYREEEEVQQEEEQLLRE 1156 Query: 644 IED----QEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEK 699 + QE+ + E + + +E E +L+E EK QE + ++ EE ++ Sbjct: 1157 EPEKRRRQELERQYREEEELQQEE--EQLLREEQEKRRQE-------RERQYREEEELQR 1207 Query: 700 DKSKLWEESTAQVKDKK-AGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKE 758 K K Q D K P E +D+ V G F E + + + Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK----VYCKGRENEQFRQLEDSQLRDRQS 1263 Query: 759 SQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQ 818 Q L ++++ +E Q RD P EQ Sbjct: 1264 QQDLQHLLGEQQERDREQERRRWQQRDRHF-------------------------PEEEQ 1298 Query: 819 PELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEK 878 E E+ KR +++ L ++E EK Sbjct: 1299 LEREEQKEAKRR------------------------------DRKSQEEKQLLREEREEK 1328 Query: 879 QALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVA 938 + ETD+ E EQ L++ E L + E E+G Sbjct: 1329 RRRQ----ETDRKFREEEQLLQE----REEQPLRRQERDRKFREEELRHQEQGR------ 1374 Query: 939 VSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFT 998 + E + + E E+ + ++ ++ + +E ++ + + R F Sbjct: 1375 -KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433 Query: 999 GEAEASRMQVSEGS--PEEGSLAKEAFLCKEDVEGEEMVTEAEA---NREDDRKEILPKE 1053 E + R Q E EE L +E ++ E E+++ E E +R++ ++ L +E Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERH--RKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491 Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANAL----KDEDAFKEEQKLKAEEGETETEV 1109 L R+ R + + LR + ER+ + L + +EEQ+L+ +E + Sbjct: 1492 QQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR-- 1549 Query: 1110 RAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLEN 1169 R + + K E E + E D L E ++ K +E+ Sbjct: 1550 RQDRDRKFREEEQLRQEREEQQLSRQE-RDRKFRLEEQKVRRQEQE--------RKFMED 1600 Query: 1170 ITALRKEGGGERLSEARDTEHKDREE-LSSRENRALKEGHRQDGEGALAAPEAEPAGKVQ 1228 LR++ G ++L + RD + ++ E+ L RE + L HRQ+ + E EP + Q Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL---HRQERDRKFL--EEEPQLRRQ 1655 Query: 1229 APEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREE 1288 + E+ D D E + Q G + LR QE KFREE Sbjct: 1656 ----------EREQQLRHDRDRKFREEEQLL-QEGEEQQLRRQE--------RDRKFREE 1696 Query: 1289 AVDEDPEEEEDK----ECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLH 1344 +E E K E L + ++ + E + + Q +++ E L Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756 Query: 1345 GGGETAETAAEEREVLAGSE-----TAEEKTIANKASSFSDVAEEETWHQQDE-LVGKTA 1398 E + +ER+ E EE+ + ++ S EE+ +++E + Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ 1816 Query: 1399 AAGKVVVEE--LARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEE 1450 GK EE L +E +E Y E T R+ L QE+E+ Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ 1870 Score = 59.7 bits (143), Expect = 2e-08 Identities = 178/995 (17%), Positives = 360/995 (36%), Gaps = 132/995 (13%) Query: 402 GLDKKPSLPKSRKEK--STEKGEELKKAEGKVRKEREYVI---PKRNEIKENKTSVSAKF 456 G ++K + R+++ E+ +E +K E +RKE E + P+R + + K Sbjct: 222 GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281 Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEE 516 QE++ +E EE Q+ L +Q+ K E EE E EE++ ++ E Sbjct: 282 ERQELRRERQE-----EEQQ------QQRLRREQQLRRKQE-EERREQQEERREQQERRE 329 Query: 517 GQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEED--- 573 Q + + + + + ++ L E+E E Q+ ++ + E E +L + Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389 Query: 574 --------------------------------KQDMKTASSTSSRSHPYSSDSEDESAVG 601 +Q ++ + + ++ Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449 Query: 602 DREAHTD-------SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADV 654 ++E D + E RR + + ++ R+ L +EE E E QE + + Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE--EERREQQERREQQL 507 Query: 655 ETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKD 714 + +E E LK E+ + + + L + EE+ + K EE + + Sbjct: 508 RREQ---EERREQRLKRQEEE--ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562 Query: 715 KKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEA 774 ++ L +E +D L +E +E ++ +++ E+ E Sbjct: 563 REQRLKREQEERRDQLLK-------------REEERRQQRLKREQEERLEQRLKREEVER 609 Query: 775 MEEDEAPQHR--DADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIP 832 +E++E + R + + + + L E + R + EQ E E+ ++ E Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSE----EQEERRQQQLRREQQERREQRLKREEEE 665 Query: 833 PGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSK------DEAPEKQALMLTVL 886 +E+ + E E RR E + QA + + K EA +Q+ + Sbjct: 666 ERLEQRLKREHEEE--RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY--- 720 Query: 887 ETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSE-------EGEAEGGVAV 939 + EG++ ++ L+ E A R+ E + +AE Sbjct: 721 -SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE---EK 776 Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTG 999 S+ G A L + + A +R+ E+ L EE ++R+ R + F Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQ-REQRFLPEEEEKEQRRRQRREREKELQFLE 835 Query: 1000 EAE--ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057 E E R + + EE L ++ + + + + E R+ Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895 Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 +E+ + E+ + + +REE + + E ++EE++L+ EE + E R + + Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955 Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEG 1177 + D + + E L + P ++ E E+ L R+ Sbjct: 956 RERQYRKDKKLQQK-EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014 Query: 1178 GGERLSEARDTEHKDREEL--SSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235 ER +D ++ E+L RE R L+E RQ E ++Q E Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE----------EEELQQEE---- 1060 Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPE 1295 E+L ++ ++ E + + ++ ++ + EE + RE E+ E Sbjct: 1061 -----EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115 Query: 1296 EEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNE 1330 ++++E L E + R E + E Q+ E Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150 Score = 56.6 bits (135), Expect = 2e-07 Identities = 167/802 (20%), Positives = 304/802 (37%), Gaps = 72/802 (8%) Query: 757 KESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGA--VHEAPLRAWK- 813 ++ ++L + EK+E +E+ + Q RD ++ + + E W E E L++ K Sbjct: 143 EQERELAEGEEQSEKQERLEQRDR-QRRDEELWRQRQE---WQEREERRAEEEQLQSCKG 198 Query: 814 -PTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGG--SDPIGQAAAKDAVGL 870 T E P+ EE +RE+ +E +G E + RR + + + K L Sbjct: 199 HETEEFPD--EEQLRRREL---LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253 Query: 871 SKDEA------PEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALRE 924 K+E P++Q + E + E E+ + L E E Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313 Query: 925 AATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKER 984 +E E E E+ ++ + ++E+ E L E+ + R Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373 Query: 985 KEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDV--EGEEMVTEAEANR 1042 ++ +R E +L +++ + E L +E L +E +++ E E R Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433 Query: 1043 EDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANAL--KDEDAFKEEQKLKA 1100 + + E +E L RE+ ER R+ ++ER E R +D++ + E+ LK Sbjct: 434 HEQKHEQERREQRLKREQE--ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491 Query: 1101 EEGET-ETEVRAEEETKAPPNEMGSDA----ENEAPVEASELSDNPGLLGEDSLKETVVP 1155 EE E E + R E++ + E E E ++ S+ ++ +E ++ Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551 Query: 1156 IFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGA 1215 E EK LE R+E +R E R + REE R + LK + E Sbjct: 552 REE-----EKRLEQE---RREQRLKREQEERRDQLLKREE--ERRQQRLKREQEERLEQR 601 Query: 1216 LAAPEAEPAGKVQAPEGLIPATGQAEE-----LAAKDHDSCAGLEGRAEGQGGVDVVLRT 1270 L E E + + E + EE L +++ + + R E Q + L+ Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661 Query: 1271 QEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNE 1330 +E + + + EE +++ EEE ++ E ++ R + +E E + ++++ Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQAR---ERIKSRIPKWQWQLESEADARQSK 718 Query: 1331 GMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETA-EEKTIANKASSFSDVAEEETWHQ 1389 R G+ EE+ SE +E+ A++ + + TW Sbjct: 719 VYSRPRKQE-------GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771 Query: 1390 QDELVGKTA----AAGKVVVEELARS--GEEVPAAEEMTVTYTTEAGVGTPGALERKTSG 1443 Q E + +A + E+ R EE E+ + E ER+ Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831 Query: 1444 LGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERE------LSPESLQAMATL 1497 E+EE + +E A + +E G E S+E R+ L E + TL Sbjct: 832 QFLEEEEQLQRRERAQQLQE--EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889 Query: 1498 PVKPDFTETREKQQHMVQGESE 1519 KP E K+Q ++Q E E Sbjct: 890 YAKPALQEQLRKEQQLLQEEEE 911 Score = 56.2 bits (134), Expect = 2e-07 Identities = 166/846 (19%), Positives = 318/846 (37%), Gaps = 102/846 (12%) Query: 414 KEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVE 473 +E+ ++ E+L + E + R+ +E R E + + QE + +E E Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202 Query: 474 EMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDD 533 E + K Q ++DQ + LK+++E E + + K +G+ + Q + S L D Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEP--EKENAVRDNKVYCKGRENEQFRQLEDSQLRD 1260 Query: 534 KKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSD 593 ++ D + ++ + + D E + ++++ K A +S Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320 Query: 594 SEDESAVGDREAHTDSSTDESAR---RSSSQELSENDKPRKSHLPIEESLEIEIEDQEIT 650 +E R TD E + Q L ++ RK EE L + + ++ Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR---EEELRHQEQGRKFL 1377 Query: 651 KADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKE---KDKSKLWEE 707 + + + + F LKE + QE + L + + EE++ +++ + + E Sbjct: 1378 EEEQRLRRQERERKF---LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434 Query: 708 STAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTY 767 QV+ ++ LEE + L +E +QL+Q Sbjct: 1435 EEQQVRRQERERKFLEE--EQQL------------------RQERHRKFREEEQLLQ--- 1471 Query: 768 TLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTE 827 E E+ Q RD ++ + + E LR+ +P E+ L EE Sbjct: 1472 -----EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP--ERKFLEEEQQL 1524 Query: 828 KREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP---EKQALMLT 884 R+ +R + E + +RR G Q +D ++E E++ L+ Sbjct: 1525 HRQ-----QRQRKFLQEEQQLRRQERG------QQRRQDRDRKFREEEQLRQEREEQQLS 1573 Query: 885 VLETDKAASEGEQGL-----EKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939 E D+ EQ + E+ + +E E ++ R+ E+ + Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL------ 1627 Query: 940 SDVGESEEEASIDLE-DTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFT 998 + E EE+ E D +E+ R E+ + +R R E +L Sbjct: 1628 --LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL------RHDRDRKFREEEQLLQEG 1679 Query: 999 GEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLAR 1058 E + R + EE + ++ ++ E+ + E R+ +E L +E + + Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739 Query: 1059 ERRKAERPKTSLRKTD--SEREEVTRANALKDEDAFKEEQKLKAE-------EGETETEV 1109 RR+ ER + L + EREE +D F+EE++L+ E E++ + Sbjct: 1740 LRRQ-ERYRKILEEEQLRPEREEQQLRRQERDRK-FREEEQLRQEREEQQLRSQESDRKF 1797 Query: 1110 RAEEETKAPPNE-----MGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFE 1164 R EE+ + E D + E +L + L ++ ++ AT E Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ--E 1855 Query: 1165 KSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPA 1224 KS L +E E ++ E K REE R+ + ++ HRQ GE + + E + Sbjct: 1856 KSRREEQELWQE---EEQKRRQERERKLREEHIRRQQKE-EQRHRQVGE--IKSQEGKGH 1909 Query: 1225 GKVQAP 1230 G++ P Sbjct: 1910 GRLLEP 1915 Score = 50.1 bits (118), Expect = 2e-05 Identities = 153/765 (20%), Positives = 264/765 (34%), Gaps = 116/765 (15%) Query: 567 ESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSEN 626 E + + +D + R + E E A G+ ++ ++ R+ +EL Sbjct: 117 EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWR- 175 Query: 627 DKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFEN-VLKEGTEKGTQEIAEGLS 685 ++ E E E + K ET+ P +E L E KG +E + Sbjct: 176 ---QRQEWQEREERRAEEEQLQSCKGH-ETEEFPDEEQLRRRELLELRRKGREEKQQQRR 231 Query: 686 EKSGKHVSAEEKE----------KDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYV 735 E+ + EE++ K++ KL EE + ++ + L + + L Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL----- 286 Query: 736 LALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEA 795 ++ QQ +++ L +K+ EE+ Q + Q + E Sbjct: 287 --------------RRERQEEEQQQQRLRREQQLRRKQ--EEERREQQEERREQQERRE- 329 Query: 796 ALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGG 855 + E LR + + +L E E+R + R E + +RR Sbjct: 330 ----QQEERREQQLRREQEERREQQLRREQEEERR-EQQLRREQEEERREQQLRREQ--- 381 Query: 856 SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEH 915 Q + + + E+Q L ++ +Q + L E E Sbjct: 382 -----QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436 Query: 916 LHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAIL 975 HE + E+ E D + EEE ++ + + E+ E + Sbjct: 437 KHEQERREQRLKREQEERR------DWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490 Query: 976 GGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMV 1035 EE +E++E + R E E R Q + EE L + L E +++ Sbjct: 491 LEEEERREQQERREQQLRR-----EQEERREQRLKRQEEEERLQQR--LRSE----QQLR 539 Query: 1036 TEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEE 1095 E E RE K K L+ R ++ +R + R +REE R LK E + E Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599 Query: 1096 QKLKAEEGE-TETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVV 1154 Q+LK EE E E E R E+ K E P E + LK Sbjct: 600 QRLKREEVERLEQEERREQRLK-----------REEPEEERR---------QQLLKSE-- 637 Query: 1155 PIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEG 1214 E+ LR+E E R+ K EE E R +E + E Sbjct: 638 ---------EQEERRQQQLRRE-----QQERREQRLKREEEEERLEQRLKREHEEERREQ 683 Query: 1215 ALAAPEAEPAG---KVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQ 1271 LA E E A K + P+ +A+ +K + EG+ Q + Sbjct: 684 ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ-------EQE 736 Query: 1272 EAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEG 1316 E + + + E A + EEE+ ++ T + +A ++++ G Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA-EEKSERG 780 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 69.3 bits (168), Expect = 3e-11 Identities = 223/1076 (20%), Positives = 406/1076 (37%), Gaps = 163/1076 (15%) Query: 523 MNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASS 582 ++G P SP+ D P+ + ++ D R N +DE E EL E+++ + Sbjct: 197 LSGSPASPMGDILQT--PQFQMRRLKKQLADERSN-RDE----LELELAENRKLL----- 244 Query: 583 TSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSS----QELSE-NDKPRKSHLPIE 637 +E ++ + + D + ++++S +EL E DK + + Sbjct: 245 -----------TEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293 Query: 638 ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGT--QEIAEGLSEKSGKHVSAE 695 E+L+ + +D + K+ ++ K + E ++ + E + Q++ + L+E + +H A Sbjct: 294 ETLK-QCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKAT 352 Query: 696 EKEKDK-SKLWEESTAQVKDKKA----------GLPGLEEGG---KDSLPLAYVLALGAP 741 ++ +K ++L +E +A ++DKK L LEE +D+ P LG Sbjct: 353 QEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLG-- 410 Query: 742 TMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEA 801 D +E+ L L+ + M E E +G+ EA L E Sbjct: 411 ------DVLQLETLKQEAATLAANNTQLQARVEMLETE----------RGQQEAKLLAER 454 Query: 802 GAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG---AAEAEGVRRLGEGGS-- 856 G E E+ +L+ T+ + + + E A++A G R + S Sbjct: 455 GHFEE----------EKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT 504 Query: 857 ------DPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAA 910 + Q ++ GL K +A EKQA + L+ + AS+G L ++ Sbjct: 505 SELTTLNATIQQQDQELAGL-KQQAKEKQAQLAQTLQQQEQASQG--------LRHQVEQ 555 Query: 911 LNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGS 970 L+ + L+E A +E + E EAS+ D + A ++E + Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615 Query: 971 EEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVE 1030 + IL +++ + E R S T +A R + E A +E E Sbjct: 616 KLEIL-------QQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHE 668 Query: 1031 GEEMVTEAEANREDDR-----KEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANA 1085 + V E E ++ KE + +E D +E+ +A + + K E E+ A+A Sbjct: 669 AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728 Query: 1086 LKDEDAFKEEQKL---------KAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASE 1136 L+++ E K K E E E E + +A ++G + E V E Sbjct: 729 LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE 788 Query: 1137 LSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGG---ERLSEARDTEHKDR 1193 L++ + + + + + + + + E+ + G E+L ++ K R Sbjct: 789 LAE--AMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846 Query: 1194 EEL-SSRENRALKEGH------RQDGEGA-LAAPEAEPAGKVQAPEGLIPATGQAEELAA 1245 +EL ++E A E H RQ E A L A A +VQ E + A A++L+ Sbjct: 847 QELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKE--VRAQKLADDLST 904 Query: 1246 KDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP---EEEEDKEC 1302 A + A + V QE + E ++ E R A D P EE++ ++ Sbjct: 905 LQEKMAATSKEVARLETLVRKAGEQQETASRE--LVKEPAR--AGDRQPEWLEEQQGRQF 960 Query: 1303 TLETEAMQ--DRNSEGDGD---------MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAE 1351 A+Q +R +E G+ ME +G Q+ G V + G Sbjct: 961 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--ARLTQERGRAQA 1018 Query: 1352 TAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKV------VV 1405 A E+ A E + + + F+ + +E H E GK K+ + Sbjct: 1019 DLALEKAARAELEMRLQNALNEQRVEFATL-QEALAHALTEKEGKDQELAKLRGLEAAQI 1077 Query: 1406 EELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGR 1465 +EL + V +E E G+ + + +G + E A + + Sbjct: 1078 KELEELRQTVKQLKEQLAKKEKEHASGS--GAQSEAAGRTEPTGPKLEALRAEVSKLEQQ 1135 Query: 1466 QETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTETREKQQHMVQGESETA 1521 + + L S E ER E A+ TL + EK Q + +S A Sbjct: 1136 CQKQQEQADSLERSLEAERASRAERDSALETLQ-----GQLEEKAQELGHSQSALA 1186 Score = 39.3 bits (90), Expect = 0.030 Identities = 143/710 (20%), Positives = 271/710 (38%), Gaps = 72/710 (10%) Query: 497 EYEEDFEVDEEKQGEKSNEEG--QADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDA 554 + +E+ E + + E G QAD+ + ++ L+ + N E+ E ++ + A Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053 Query: 555 RDNVKDEN-----------DGCSESELEEDKQDMKTASST-SSRSHPYSSDSEDESAVGD 602 + E + ELEE +Q +K + + ++S S +S Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113 Query: 603 REAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPID 662 R T E+ R S+ + K ++ +E SLE E + + +ET ++ Sbjct: 1114 RTEPTGPKL-EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172 Query: 663 ESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGL 722 E + E G + A L+ + + K +D SK +E AQV + Sbjct: 1173 EKAQ-------ELGHSQSA--LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ----- 1218 Query: 723 EEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQ 782 E K+SL + L +N V E +KE ++LV E +++ + +E + Sbjct: 1219 EAERKNSLISS--LEEEVSILNRQVLEKEG--ESKELKRLVMA----ESEKSQKLEERLR 1270 Query: 783 HRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGA 842 A+ AA E + +++ + AE+ +A E ++E+ ER E Sbjct: 1271 LLQAETASNSARAA---ERSSALREEVQSLREEAEKQRVASE-NLRQELTSQAERAEELG 1326 Query: 843 AEAEGVRRLGEGGSDPIG--QAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900 E + + + Q L + P K + L+ ++AA+E E Sbjct: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH--LCQQLQAEQAAAEKRHREE 1384 Query: 901 KAVLANEAAALNLE------HLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLE 954 A L E L E+ LR+ +E A+ A + E+ S+ + Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRA--EKASYAEQLSMLKK 1442 Query: 955 DTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETR-LSPFTGEAEASRMQVSEGSP 1013 G + A + E A LG + E + + L+ +AE +++E Sbjct: 1443 AHGLL---AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET---RLAEVQR 1496 Query: 1014 EEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT 1073 E S A+E + EG ++ E R + ++ L ++ E+ + R+ Sbjct: 1497 EAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV---------EQLEVFQREQ 1547 Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSD-AENEAPV 1132 + EE+++ A D+ + ++QKLKA + + + + +A NE+ + ++ E Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAA 1607 Query: 1133 EASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERL 1182 E +L D+ K+ + E E+ + LR E ERL Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAE--AERL 1655 >gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo sapiens] Length = 1937 Score = 69.3 bits (168), Expect = 3e-11 Identities = 180/957 (18%), Positives = 383/957 (40%), Gaps = 80/957 (8%) Query: 403 LDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462 L+ K R E+ E EL + K+ E + ++++ V + A E K Sbjct: 918 LEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 977 Query: 463 T-GLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521 L E + ++E +K ++ L++ + TL +D + +E+K + + + + Sbjct: 978 VKNLTEEMAGLDETIAKLSKEKKALQETHQQTL-----DDLQAEEDKVNILTKAKTKLEQ 1032 Query: 522 QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTAS 581 Q++ + S +KK +D E+ A+++ D + + + + +K++ + ++ Sbjct: 1033 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISN 1092 Query: 582 STSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLE 641 S + + + + + + +A + +E +S+ +E + S +EE E Sbjct: 1093 LISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSR-ELEEISE 1151 Query: 642 IEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDK 701 E T A VE E+ L+ E+ T + ++ KH + + ++ Sbjct: 1152 RLEEAGGATSAQVELNKK--REAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQ 1209 Query: 702 SKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALG--APTMNFMVDETAAINSNKES 759 + +++ +K+ L +E S A A G + D+ + + + +E Sbjct: 1210 IDNLQRVKQKLEKEKSELK-METDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEE 1268 Query: 760 QQLVQKTYTLEKKEAMEE--DEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAE 817 QQ + T ++ E + + Q + D + + + + E + + T Sbjct: 1269 QQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKA 1328 Query: 818 QPELAEEFTEKRE----IPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAK---DAVGL 870 + LA R + E EG AE + R L + S+ + Q K DA+ Sbjct: 1329 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQ--RALSKANSE-VAQWRTKYETDAIQR 1385 Query: 871 SK--DEAPEKQALMLTVLETDKAASEGE-QGLEKAV--LANEAAALNLEHLHEVAALREA 925 ++ +EA +K A L E A + LEK L NE L L+ AA Sbjct: 1386 TEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAA---C 1442 Query: 926 ATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEA----ILGGEEPA 981 A ++ + +S+ + EE +LE AS++E S + E + Sbjct: 1443 AALDKKQRNFDKVLSEWKQKYEETQAELE--------ASQKESRSLSTELFKVKNVYEES 1494 Query: 982 KERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK-EAFLCKEDVEGEEMVTEAEA 1040 ++ E +R E + E Q++EG + L K + + +E E + + EAEA Sbjct: 1495 LDQLETLRRENK--NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552 Query: 1041 NREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTR--------------ANAL 1086 + E + +IL +L+L + + + +R + + D E +++ R A Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQLKRNHTRVVETMQSTLDAEIR 1609 Query: 1087 KDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGE 1146 DA + ++K++ + E E++ + + + + ++ ++L + L G+ Sbjct: 1610 SRNDALRVKKKMEGD--LNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQ 1667 Query: 1147 DSLKETVVPIFEATPGFEKSLENITA-LRKEGGGERLSEARDTEHKDREELSSRENRALK 1205 + LKE + + + +E + A L + +++E + +R +L +N +L Sbjct: 1668 EDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1727 Query: 1206 EGHRQ-DGEGALAAPEAEPA------GKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRA 1258 ++ + + + E E + +A + + A AEEL K+ D+ A LE Sbjct: 1728 NTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEEL-KKEQDTSAHLERMK 1786 Query: 1259 EGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSE 1315 + ++ ++ + +E +A K ++ + + E +E E E Q RN+E Sbjct: 1787 K---NLEQTVKDLQHRLDEAEQLALKGGKKQIQK--LEARVRELEGEVENEQKRNAE 1838 Score = 52.8 bits (125), Expect = 3e-06 Identities = 156/775 (20%), Positives = 298/775 (38%), Gaps = 96/775 (12%) Query: 399 IAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSA 458 + + L KK ++R E+ E+ E + + K K+R + + EI E SA Sbjct: 1103 VEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSA 1162 Query: 459 QEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQ 518 Q VE + Q++ D +E TL ++E +K + E G+ Sbjct: 1163 Q------------VELNKKREAEFQKLRRDLEEATL--QHEAMVAALRKKHADSMAELGE 1208 Query: 519 ADVQMNGIPQSPLDDKKDNLDPEKESETSSQKA-PDARDNV----KDENDGCSESELEED 573 + + Q L+ +K L E + +S+ +A A+ N+ + D SE + +E+ Sbjct: 1209 QIDNLQRVKQK-LEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEE 1267 Query: 574 KQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSE----NDKP 629 +Q T+ R+ + E + +++A S ++++S+Q++ E ++ Sbjct: 1268 EQQRLINDLTAQRARLQTEAGEYSRQLDEKDALV--SQLSRSKQASTQQIEELKHQLEEE 1325 Query: 630 RKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSG 689 K+ + +L+ D ++ + E ++ + L+ K E+A+ ++ Sbjct: 1326 TKAKNALAHALQSSRHDCDLLREQYEE-----EQEGKAELQRALSKANSEVAQWRTKYET 1380 Query: 690 KHVS-AEEKEKDKSKL---WEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNF 745 + EE E+ K KL +E+ V+ A LE+ + L L N Sbjct: 1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSN- 1439 Query: 746 MVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVH 805 AA++ + + V + + +E E EA Q + L+ Sbjct: 1440 --AACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL-----STELFKVKNVYE 1492 Query: 806 EAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAK 865 E+ + E L +E ++ E I G + E E +++ E I QAA + Sbjct: 1493 ESLDQLETLRRENKNLQQEISDLTE---QIAEGGKQIHELEKIKKQVEQEKCEI-QAALE 1548 Query: 866 DAVGLSKDEAPEKQALMLTV----LETDKAASEGEQGLEK------AVLANEAAALNLEH 915 +A + E + + L + E D+ +E ++ +++ V+ + L+ E Sbjct: 1549 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEI 1608 Query: 916 LHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDT-GPMEDTASKREDGSEEAI 974 ALR E E + ++ E+ + +T G +++T +D Sbjct: 1609 RSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA----- 1663 Query: 975 LGGEEPAKERKEVMRTETRLSPFTGE---------------AEASRMQVSEG----SPEE 1015 L G+E KE+ ++ L E AE + SE + Sbjct: 1664 LRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723 Query: 1016 GSLAKEAFLCKEDV-----EGEEMVTEAEANREDDRKEILPKELDLARERRK-------A 1063 SL + DV E EE++ E+ N E+ K+ + +A E +K Sbjct: 1724 TSLINTKKKLENDVSQLQSEVEEVIQESR-NAEEKAKKAITDAAMMAEELKKEQDTSAHL 1782 Query: 1064 ERPKTSLRKTDSE-REEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 ER K +L +T + + + A L + K+ QKL+A E E EV E++ A Sbjct: 1783 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNA 1837 >gi|7657138 golgi integral membrane protein 4 [Homo sapiens] Length = 696 Score = 68.9 bits (167), Expect = 3e-11 Identities = 145/717 (20%), Positives = 264/717 (36%), Gaps = 115/717 (16%) Query: 411 KSRKEKSTEKGEELKKAEGKVRKER--EYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEV 468 +SR EKS +K ++ E K KE Y + + + + + ++++SA + Sbjct: 68 RSRLEKSLQK----ERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNV------- 116 Query: 469 VTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ 528 Q + Q LK ++ D E + KQGE + Sbjct: 117 --------------QHQMLKSQHEELKKQHS-DLEEEHRKQGEDFSRTFN---------- 151 Query: 529 SPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSH 588 D K+ L ++E E K + N+++EN +L + QD+ T + H Sbjct: 152 ---DHKQKYLQLQQEKEQELSKLKETVYNLREEN-----RQLRKAHQDIHTQLQDVKQQH 203 Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQE 648 + SE E V E H +SA ++ +++E K K L SL Sbjct: 204 K-NLLSEHEQLVVTLEDH------KSALAAAQTQVAEY-KQLKDTLNRIPSLR------- 248 Query: 649 ITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEES 708 KP P ++ +NV + A EK + V + D + E Sbjct: 249 --------KPDPAEQ--QNVTQVAHSPQGYNTAR---EKPTREVQEVSRNNDVWQNHEAV 295 Query: 709 TAQVKDKKAGLPGLEEGGKDSLP--LAYVLALGAPTMNFMVDETAAINSNKESQQLVQKT 766 + +D K P +E + P + + P + + +E +E +Q+ Q Sbjct: 296 PGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355 Query: 767 YTLEKKEAMEEDEAPQHRD-------ADIVQGKGEAALWGEAGAV------HEAPLRAWK 813 + E+ + E++ + ++ A++++G A ++ A + +E L + Sbjct: 356 HLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQR 415 Query: 814 PTAEQPELAEEFTEKREIPPGIERGAEGAAEAEG-VRRLGEGGSDPIGQAAAKDAVGLSK 872 +Q E A++ E +E A +G + R E + + A + Sbjct: 416 LAVQQVEEAQQLREHQE--------ALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELE 467 Query: 873 DEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGE 932 + P+ Q + D ++ QG E + E A ++ H+ A + E Sbjct: 468 EGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPR 527 Query: 933 AEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTET 992 +G E++ A +ED P +D ++ ED EEA EE + E + Sbjct: 528 EQGPREADPESEADRAA---VEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSN 584 Query: 993 RLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPK 1052 + T E V G+P++ +ED E+ EAE ++D E + Sbjct: 585 QKQENT---EVEEHLVMAGNPDQ----------QEDNVDEQYQEEAEEEVQEDLTEEKKR 631 Query: 1053 ELDLARERRKAERPK-TSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETE 1108 EL+ E E + T + D E +EV N K + EE++ + E+G E Sbjct: 632 ELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAE 688 Score = 43.1 bits (100), Expect = 0.002 Identities = 102/503 (20%), Positives = 180/503 (35%), Gaps = 95/503 (18%) Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRK 1062 A++ QV+E + +L + L K D ++ VT+ + P+ + ARE Sbjct: 226 AAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHS---------PQGYNTARE--- 273 Query: 1063 AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKL--KAEEGETETEVRAEEETKAPPN 1120 K E +EV+R N D ++ + + +AE+ + E E +APP Sbjct: 274 ---------KPTREVQEVSRNN-----DVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE 319 Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180 + + E P E ++ L E+ +++ G E Sbjct: 320 PIQQEVERREPEEHQVEEEHRKALEEEEMEQV------------------------GQAE 355 Query: 1181 RLSEARD--TEHKDR---EELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAP----- 1230 L E D E +DR E+ RE L EGH + A P A+P K Q+P Sbjct: 356 HLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR----AEVYPSAKPMIKFQSPYEEQL 411 Query: 1231 EGLIPATGQAEELAAKDHDSCAGLEGRAEG-----------QGGVDVVLRTQEAVAEEDP 1279 E A Q EE A + R +G Q ++ L+ Q + E P Sbjct: 412 EQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRP 471 Query: 1280 IMAEKFRE----EAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGE-GNTQKNEGMGG 1334 E+ R+ +A+D D + + + E +R+++ + EG+ GN + G Sbjct: 472 QHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGP 531 Query: 1335 GRV--------VAVEVLHGGGETAETAAEEREVLAGSETAEEKTI--ANKASSFSDVAEE 1384 AVE ++ + +E E +E E+ + N+ S+ +E Sbjct: 532 READPESEADRAAVEDINPADDPNNQGEDEFE---EAEQVREENLPDENEEQKQSNQKQE 588 Query: 1385 ETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGL 1444 T ++ ++ + V+E + E E++T E Sbjct: 589 NTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENT 648 Query: 1445 GQEQEEGSEGQEAATGSGDGRQE 1467 + +G E + GR+E Sbjct: 649 DDKNNDGEEQEVRDDNRPKGREE 671 Score = 38.5 bits (88), Expect = 0.050 Identities = 78/379 (20%), Positives = 144/379 (37%), Gaps = 41/379 (10%) Query: 947 EEASIDLEDTGPMEDTASKR----EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 EE ++ E +E+ ++ E EE EE +E KE + G A Sbjct: 331 EEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR 390 Query: 1003 A-----SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057 A ++ + SP E L ++ ++ E +++ EA + + L ++ + Sbjct: 391 AEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQ 450 Query: 1058 RE---RRKAERPKTSLRKTDSEREEVTRANA---LKDEDAFK--EEQKLKAEEGETETEV 1109 ++ R A + + L + + +E R A D D + E+Q ++ EEG E + Sbjct: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDN 510 Query: 1110 RAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLEN 1169 + ++E + P E + P EA S+ + + E + P + E E Sbjct: 511 QHQDEAEGDPGNRHEPRE-QGPREADPESE-----ADRAAVEDINPADDPNNQGEDEFEE 564 Query: 1170 ITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQA 1229 +R+E + E + + K +E + E + G+ E + E A + + Sbjct: 565 AEQVREENLPDENEEQKQSNQK--QENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEE-EV 621 Query: 1230 PEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAE---KFR 1286 E L E+ +H++ E G D + EE + + K R Sbjct: 622 QEDLTE-----EKKRELEHNA-------EETYGENDENTDDKNNDGEEQEVRDDNRPKGR 669 Query: 1287 EEAVDEDPEEEEDKECTLE 1305 EE +E+ EEEED E Sbjct: 670 EEHYEEEEEEEEDGAAVAE 688 Score = 36.6 bits (83), Expect = 0.19 Identities = 29/144 (20%), Positives = 62/144 (43%), Gaps = 12/144 (8%) Query: 488 DDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA-------DVQMNGIPQSPLDDKKDNLDP 540 DD N + E+EE +V EE +++ E+ Q+ +V+ + + D ++DN+D Sbjct: 552 DDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDE 611 Query: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV 600 + + E + D + K E + +E E+ ++ ++ + D++ Sbjct: 612 QYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGE-----EQEVRDDNRP 666 Query: 601 GDREAHTDSSTDESARRSSSQELS 624 RE H + +E ++ E S Sbjct: 667 KGREEHYEEEEEEEEDGAAVAEKS 690 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 68.2 bits (165), Expect = 6e-11 Identities = 153/783 (19%), Positives = 299/783 (38%), Gaps = 97/783 (12%) Query: 415 EKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEE 474 E+ TE+ E+ K+A+ + K ++ + K N + V + + QE++ K++ V+E Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQ-TLEKENADLAGELRVLGQ-AKQEVEHKKKKLEAQVQE 1263 Query: 475 MTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ--SPLD 532 + SK G+ + + K + E E G + EG+A + S L Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318 Query: 533 DKKDNLDPEKESE----TSSQKAPDARDNVKDENDGCSES-------------ELEEDKQ 575 D ++ L E + T ++ + R++++D+ D E+ +L + K+ Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378 Query: 576 DMKTASST-----------SSRSHPYSSDSEDESAVGDREAHT---------DSSTDESA 615 ++ +ST + E+++A D+ T D D Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438 Query: 616 RRSSSQELSENDKPRKSHLPIEESLEIEIEDQ----EITKADVETKPMPIDESFENVL-- 669 +R L + + L E+++ + D+ E + ETK + + + E L Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498 Query: 670 KEGTEKGTQ----EIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEG 725 KE E+ + E+ + +S K + E EK K L Q+++ K L LE+ Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL----ETQMEEMKTQLEELEDE 1554 Query: 726 --GKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQH 783 + L + + A F D A N+E ++ +Q+ L + E EDE Q Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ--LHEYETELEDERKQR 1612 Query: 784 RDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAA 843 A + K E G + + L+A + E ++ + + +R E A Sbjct: 1613 ALAAAAKKKLE-------GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665 Query: 844 EAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE-KA 902 + ++ ++ D + L +D A ++A LE ++ A E L + Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725 Query: 903 VLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD-VGESEEEASIDLEDTGPMED 961 L +E L +A L E E+G E A+SD V ++ ++A + Sbjct: 1726 ALQDEKRRLEAR----IAQLEEELEEEQGNME---AMSDRVRKATQQAEQLSNELATERS 1778 Query: 962 TASKREDGSEEAI------------LGGEEPAKERKEVMRTETRLSPFTGEAEAS---RM 1006 TA K E ++ + G +K + + E +++ + E + Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838 Query: 1007 QVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 ++ ++ KE L ED + +A + + R + L ++L+ A E +++R Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--ESQRI 1896 Query: 1067 KTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126 + RK E +E T +N + + KL+ + R + N GS+ Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1956 Query: 1127 ENE 1129 E + Sbjct: 1957 ETD 1959 Score = 61.6 bits (148), Expect = 6e-09 Identities = 211/1152 (18%), Positives = 418/1152 (36%), Gaps = 142/1152 (12%) Query: 406 KPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSA----KFSAQEI 461 KP L +R+E EE++ E +++K +E NE+KE + S K QE Sbjct: 842 KPLLQVTRQE------EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895 Query: 462 KTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521 E+ EEM + ++ LE+ + +E E E +E++ + E + Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQ 950 Query: 522 QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNV---KDENDGCSESE--LEEDKQD 576 QM + + +++ + E T+ K D + D+N+ S+ LEE D Sbjct: 951 QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010 Query: 577 MKT--ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHL 634 + T A + ++ ES + + E + E D Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070 Query: 635 PIEESLEIEIEDQEITKADVETKPM--PIDESF---ENVLKE--GTEKGTQEIAEGLSEK 687 + +I ++ K + E + +D+ N LK+ E ++ E L + Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130 Query: 688 SGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMV 747 AE++++D + E +++D +E VL Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190 Query: 748 DETAAINSNKESQQLVQKTYTLE--KKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVH 805 + K +Q + + T LE K+ D+ Q + + GE + G+A Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK--Q 1248 Query: 806 EAPLRAWKPTAEQPELAEEFTE----KREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQ 861 E + K A+ EL + ++ + E+ + + G+ EG + + + Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308 Query: 862 AAA------KDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE-----AAA 910 A +D L ++E +K + + + ++ + + L++ + A + + Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368 Query: 911 LNLEHLHEVAALREAATS----EEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 LN++ L++ A++ EEG+ + ++ + EE + + +E T ++ Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK---LEKTKNRL 1425 Query: 967 E----------DGSEEAILGGEEPAKERKEVMRTETRLSP-FTGEAEASRMQVSEGSPEE 1015 + D + + E+ ++ +++ E +S + E + + + E + Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485 Query: 1016 GSLAK---EAFLCKEDVEGEEMVTEAE-----ANREDDRKEILPKELDLARERRKAERPK 1067 SLA+ EA KE++E + +AE ++++D K + E + E K Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545 Query: 1068 TSLRKTDSEREEVTRAN--------ALKDE--------DAFKEEQKLKAEEGETETEVRA 1111 T L + + E + A ALK + D EE++ + + E E Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605 Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171 E+E K + + E ++ EL + + G + + + + F++ LE+ Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665 Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPE 1231 A R E + + + + + +E+ A E R+ + E A + Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725 Query: 1232 GLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVD 1291 L + E A+ + +G E R ++A + AE+ E Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSD-----RVRKATQQ-----AEQLSNELAT 1775 Query: 1292 EDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAE 1351 E ++++ + E +MEG ++ + A+E A+ Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK-----STIAALE--------AK 1822 Query: 1352 TAAEEREVLAGSETAEEKTIANKASSFSD------VAEEETWHQQDELVGKTAAAGKVVV 1405 A E +V + A EK A K+ D + + E + E + A G V Sbjct: 1823 IAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879 Query: 1406 EELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGR 1465 ++L R EE AEE + A RK L +E +E +E EA GR Sbjct: 1880 KQLKRQLEE---AEEESQRI---------NANRRK---LQRELDEATESNEAM-----GR 1919 Query: 1466 QETGAAEKFRLG 1477 + K R G Sbjct: 1920 EVNALKSKLRRG 1931 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 68.2 bits (165), Expect = 6e-11 Identities = 153/783 (19%), Positives = 299/783 (38%), Gaps = 97/783 (12%) Query: 415 EKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEE 474 E+ TE+ E+ K+A+ + K ++ + K N + V + + QE++ K++ V+E Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQ-TLEKENADLAGELRVLGQ-AKQEVEHKKKKLEAQVQE 1270 Query: 475 MTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ--SPLD 532 + SK G+ + + K + E E G + EG+A + S L Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325 Query: 533 DKKDNLDPEKESE----TSSQKAPDARDNVKDENDGCSES-------------ELEEDKQ 575 D ++ L E + T ++ + R++++D+ D E+ +L + K+ Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385 Query: 576 DMKTASST-----------SSRSHPYSSDSEDESAVGDREAHT---------DSSTDESA 615 ++ +ST + E+++A D+ T D D Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445 Query: 616 RRSSSQELSENDKPRKSHLPIEESLEIEIEDQ----EITKADVETKPMPIDESFENVL-- 669 +R L + + L E+++ + D+ E + ETK + + + E L Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505 Query: 670 KEGTEKGTQ----EIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEG 725 KE E+ + E+ + +S K + E EK K L Q+++ K L LE+ Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL----ETQMEEMKTQLEELEDE 1561 Query: 726 --GKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQH 783 + L + + A F D A N+E ++ +Q+ L + E EDE Q Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ--LHEYETELEDERKQR 1619 Query: 784 RDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAA 843 A + K E G + + L+A + E ++ + + +R E A Sbjct: 1620 ALAAAAKKKLE-------GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672 Query: 844 EAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE-KA 902 + ++ ++ D + L +D A ++A LE ++ A E L + Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732 Query: 903 VLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD-VGESEEEASIDLEDTGPMED 961 L +E L +A L E E+G E A+SD V ++ ++A + Sbjct: 1733 ALQDEKRRLEAR----IAQLEEELEEEQGNME---AMSDRVRKATQQAEQLSNELATERS 1785 Query: 962 TASKREDGSEEAI------------LGGEEPAKERKEVMRTETRLSPFTGEAEAS---RM 1006 TA K E ++ + G +K + + E +++ + E + Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845 Query: 1007 QVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066 ++ ++ KE L ED + +A + + R + L ++L+ A E +++R Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--ESQRI 1903 Query: 1067 KTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126 + RK E +E T +N + + KL+ + R + N GS+ Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1963 Query: 1127 ENE 1129 E + Sbjct: 1964 ETD 1966 Score = 61.6 bits (148), Expect = 6e-09 Identities = 211/1152 (18%), Positives = 418/1152 (36%), Gaps = 142/1152 (12%) Query: 406 KPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSA----KFSAQEI 461 KP L +R+E EE++ E +++K +E NE+KE + S K QE Sbjct: 849 KPLLQVTRQE------EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902 Query: 462 KTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521 E+ EEM + ++ LE+ + +E E E +E++ + E + Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQ 957 Query: 522 QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNV---KDENDGCSESE--LEEDKQD 576 QM + + +++ + E T+ K D + D+N+ S+ LEE D Sbjct: 958 QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017 Query: 577 MKT--ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHL 634 + T A + ++ ES + + E + E D Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077 Query: 635 PIEESLEIEIEDQEITKADVETKPM--PIDESF---ENVLKE--GTEKGTQEIAEGLSEK 687 + +I ++ K + E + +D+ N LK+ E ++ E L + Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137 Query: 688 SGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMV 747 AE++++D + E +++D +E VL Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197 Query: 748 DETAAINSNKESQQLVQKTYTLE--KKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVH 805 + K +Q + + T LE K+ D+ Q + + GE + G+A Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK--Q 1255 Query: 806 EAPLRAWKPTAEQPELAEEFTE----KREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQ 861 E + K A+ EL + ++ + E+ + + G+ EG + + + Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315 Query: 862 AAA------KDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE-----AAA 910 A +D L ++E +K + + + ++ + + L++ + A + + Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375 Query: 911 LNLEHLHEVAALREAATS----EEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 LN++ L++ A++ EEG+ + ++ + EE + + +E T ++ Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK---LEKTKNRL 1432 Query: 967 E----------DGSEEAILGGEEPAKERKEVMRTETRLSP-FTGEAEASRMQVSEGSPEE 1015 + D + + E+ ++ +++ E +S + E + + + E + Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492 Query: 1016 GSLAK---EAFLCKEDVEGEEMVTEAE-----ANREDDRKEILPKELDLARERRKAERPK 1067 SLA+ EA KE++E + +AE ++++D K + E + E K Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552 Query: 1068 TSLRKTDSEREEVTRAN--------ALKDE--------DAFKEEQKLKAEEGETETEVRA 1111 T L + + E + A ALK + D EE++ + + E E Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612 Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171 E+E K + + E ++ EL + + G + + + + F++ LE+ Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672 Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPE 1231 A R E + + + + + +E+ A E R+ + E A + Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732 Query: 1232 GLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVD 1291 L + E A+ + +G E R ++A + AE+ E Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSD-----RVRKATQQ-----AEQLSNELAT 1782 Query: 1292 EDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAE 1351 E ++++ + E +MEG ++ + A+E A+ Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK-----STIAALE--------AK 1829 Query: 1352 TAAEEREVLAGSETAEEKTIANKASSFSD------VAEEETWHQQDELVGKTAAAGKVVV 1405 A E +V + A EK A K+ D + + E + E + A G V Sbjct: 1830 IAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886 Query: 1406 EELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGR 1465 ++L R EE AEE + A RK L +E +E +E EA GR Sbjct: 1887 KQLKRQLEE---AEEESQRI---------NANRRK---LQRELDEATESNEAM-----GR 1926 Query: 1466 QETGAAEKFRLG 1477 + K R G Sbjct: 1927 EVNALKSKLRRG 1938 >gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo sapiens] Length = 916 Score = 67.4 bits (163), Expect = 1e-10 Identities = 107/513 (20%), Positives = 198/513 (38%), Gaps = 57/513 (11%) Query: 455 KFSAQEIKTGLKEVVTAVEEMTSKGKPGQ--EVLEDDQENTLKYEYEEDFEVDEEKQGEK 512 K A ++K K V +EE + + + E L E EE E EEK+ E Sbjct: 440 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 499 Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572 EE + + + + + + K++ + E+E ++ D +G SE E Sbjct: 500 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 559 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632 +K++ + + +++E E A E + ++E A + ++ +KP K+ Sbjct: 560 EKEEGEQEEGET------EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA 613 Query: 633 HLPIEESLEIEIEDQEITKADVETK------PMPIDESFENVLKEG--TEKGTQEIAEG- 683 P+ +S E + K+ VE K P++E ++ + + EKG +++ Sbjct: 614 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 673 Query: 684 LSEKSGKHVSAEEKEKDKSKL-------WEESTAQVKD--KKAGLPGLEEGGKDSLPLAY 734 + EK+ V E+ KSK EE +VK+ K+ + EE KD Sbjct: 674 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD------ 727 Query: 735 VLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGE 794 + ++ A + KE + V + T+ K + ++ + + Q K + Sbjct: 728 -----------VPEKKKAESPVKE--EAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEK 774 Query: 795 AALWGEAGAVHEAPLRAWKPT-AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGE 853 GE G+ E + K + E + E K E+ + G E +GV G Sbjct: 775 EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNG- 833 Query: 854 GGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNL 913 + + A + G K E EK + TV +K SEG G K + + + Sbjct: 834 -----LDLSPADEKKGGDKSE--EKVVVTKTV---EKITSEGGDGATKYITKSVTVTQKV 883 Query: 914 EHLHEVAALREAATSEEGEAEGGVAVSDVGESE 946 E E + +T + + V +V +S+ Sbjct: 884 EEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 916 Score = 65.5 bits (158), Expect = 4e-10 Identities = 109/475 (22%), Positives = 190/475 (40%), Gaps = 67/475 (14%) Query: 907 EAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 EA L ++H + E +E ++E A++ + EE ++ ++ E+ Sbjct: 442 EAPKLKVQHKFVEEIIEETKVEDE-KSEMEEALTAI---TEELAVSMK-----EEKKEAA 492 Query: 967 EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCK 1026 E+ EE EE A ++ V T + GE E Q E +EG+ + +A Sbjct: 493 EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA---- 548 Query: 1027 EDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANAL 1086 EE +E E + E + E E + E +AE + +K + + EEV L Sbjct: 549 -----EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE--KKVEEKSEEVATKEEL 601 Query: 1087 KDEDAFKEEQKLKAEEGETETEVRAEEET-KAPPNEMGSDAENEAPVEASELSDNPGLLG 1145 + ++ +K K+ ++ E + + K+P E G ++PVE S P Sbjct: 602 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 661 Query: 1146 EDSLKETV--VPIFE--ATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSREN 1201 E+ K V P+ E +P + +E + + G GE+ ++ E K+ +E E Sbjct: 662 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ----KEEEEKEVKEAPKEEK 717 Query: 1202 RALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261 KE +D PE + K ++P EE A+ ++ E Sbjct: 718 VEKKEEKPKD------VPEKK---KAESP--------VKEEAVAEVVTITKSVKVHLE-- 758 Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQD--RNSEGDGD 1319 +E E P+ EK +E+A E EEE + + +D N E +G Sbjct: 759 ---------KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK 809 Query: 1320 MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANK 1374 E E T++ G GR V+ G + + A+E++ G + +EEK + K Sbjct: 810 EEVEQETKEK---GSGREEEKGVVTNGLDL--SPADEKK---GGDKSEEKVVVTK 856 Score = 58.5 bits (140), Expect = 5e-08 Identities = 68/333 (20%), Positives = 138/333 (41%), Gaps = 26/333 (7%) Query: 389 ERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKE- 447 + S + + A+ + S+ + +KE + EK EE + E +V ++ V E+KE Sbjct: 464 DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 523 Query: 448 --NKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVD 505 K + +E G K +G +E E ++ T E+ E Sbjct: 524 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 583 Query: 506 EEKQGEKSNEE--------GQADVQ-----MNGIPQSPLDDKKDNLDPEKESETSSQKAP 552 EEK+ E+ +EE A V+ + +P+SP+++K + P+ E K+P Sbjct: 584 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG-KSP 642 Query: 553 DARDNVKDENDG-CSESELEEDKQDMKTASSTSSRSH---PYSSDSEDESAVGDREAHTD 608 + V+++ +S +EE + + S ++ P S E +S + Sbjct: 643 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 702 Query: 609 SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENV 668 ++ + + +E E + + +P ++ E ++++ + + TK + + ++ Sbjct: 703 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV-----HL 757 Query: 669 LKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDK 701 KE E+G E EK+G +EE+ DK Sbjct: 758 EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 790 Score = 40.0 bits (92), Expect = 0.017 Identities = 119/578 (20%), Positives = 216/578 (37%), Gaps = 71/578 (12%) Query: 1000 EAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANR-EDDRKEILPKELDLAR 1058 + +AS Q+ + +E +E E V E+ + +++ E+D + + + AR Sbjct: 138 QKQASHAQLGDAYDQE---IRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEAR 194 Query: 1059 ERRKAERPKTSLRKTDSEREEVT-----RANALKDEDAFKEEQKLKAEEGETETEVRAEE 1113 R E +LRK E V + +L+DE AF + E + +++A Sbjct: 195 LRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNH-EEEVADLLAQIQASH 253 Query: 1114 ETKAPPNEMGSDAENEAPVEASEL---SDNPGLLGEDSLKETVVPIFEATPGFEKSL--- 1167 T + + +D S+L SD E+ K + EA ++++ Sbjct: 254 ITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSA 313 Query: 1168 -ENITALRKEGGGE--RLSEARDTEHKDREELSSRENR-----ALKEGHRQDGEGALAAP 1219 E I R++ + L R T+ +LS E R + + Q E L Sbjct: 314 KEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGT 373 Query: 1220 EAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGG------------VDVV 1267 + E A ++ + L+ + A G E R G + + Sbjct: 374 KWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITIS 433 Query: 1268 LRTQEAVAEEDPIMAE-KFREEAVDEDPEEEEDKEC----TLETE----AMQDRNSEGDG 1318 + Q+ E + + KF EE ++E E+E E T TE +M++ E Sbjct: 434 SKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAE 493 Query: 1319 DMEGEGNTQKNEGMGGG---RVVAVEVLHGGGETAETAAEEREVL----AGSETAEEKTI 1371 + E E ++ E + A EV GE E +E E A S+ AEE Sbjct: 494 EKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGS 553 Query: 1372 ANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGV 1431 + SS + E+E + E G+ A A + +++ EEV EE+ +A V Sbjct: 554 EKEGSSEKEEGEQEEGETEAEAEGEEAEAKE--EKKVEEKSEEVATKEEL----VADAKV 607 Query: 1432 GTPGALERKTSGLGQE--QEEGSEGQEAATGSGDGR--------QETGAAEKFRLGLSRE 1481 P E+ S + + +E+G + G+ +E G + + + + Sbjct: 608 EKP---EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 664 Query: 1482 GERELSPESLQAMATLPVKPDFTETREKQQHMVQGESE 1519 G+ +S ++ A PV E + + + +GE + Sbjct: 665 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 702 Score = 38.5 bits (88), Expect = 0.050 Identities = 36/143 (25%), Positives = 57/143 (39%), Gaps = 4/143 (2%) Query: 1383 EEETWHQQDELVGKT---AAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALER 1439 E+E ++ L T A + K +E A EE P AEE V ++ V + Sbjct: 463 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA-AKKSPVKATAPEVK 521 Query: 1440 KTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPV 1499 + G +E+E E +E G+ + E G +EK EGE+E +A Sbjct: 522 EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 581 Query: 1500 KPDFTETREKQQHMVQGESETAD 1522 + + EK + + E AD Sbjct: 582 AKEEKKVEEKSEEVATKEELVAD 604 >gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo sapiens] Length = 540 Score = 67.4 bits (163), Expect = 1e-10 Identities = 107/513 (20%), Positives = 198/513 (38%), Gaps = 57/513 (11%) Query: 455 KFSAQEIKTGLKEVVTAVEEMTSKGKPGQ--EVLEDDQENTLKYEYEEDFEVDEEKQGEK 512 K A ++K K V +EE + + + E L E EE E EEK+ E Sbjct: 64 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 123 Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572 EE + + + + + + K++ + E+E ++ D +G SE E Sbjct: 124 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 183 Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632 +K++ + + +++E E A E + ++E A + ++ +KP K+ Sbjct: 184 EKEEGEQEEGET------EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA 237 Query: 633 HLPIEESLEIEIEDQEITKADVETK------PMPIDESFENVLKEG--TEKGTQEIAEG- 683 P+ +S E + K+ VE K P++E ++ + + EKG +++ Sbjct: 238 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 297 Query: 684 LSEKSGKHVSAEEKEKDKSKL-------WEESTAQVKD--KKAGLPGLEEGGKDSLPLAY 734 + EK+ V E+ KSK EE +VK+ K+ + EE KD Sbjct: 298 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD------ 351 Query: 735 VLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGE 794 + ++ A + KE + V + T+ K + ++ + + Q K + Sbjct: 352 -----------VPEKKKAESPVKE--EAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEK 398 Query: 795 AALWGEAGAVHEAPLRAWKPT-AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGE 853 GE G+ E + K + E + E K E+ + G E +GV G Sbjct: 399 EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNG- 457 Query: 854 GGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNL 913 + + A + G K E EK + TV +K SEG G K + + + Sbjct: 458 -----LDLSPADEKKGGDKSE--EKVVVTKTV---EKITSEGGDGATKYITKSVTVTQKV 507 Query: 914 EHLHEVAALREAATSEEGEAEGGVAVSDVGESE 946 E E + +T + + V +V +S+ Sbjct: 508 EEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 540 Score = 65.5 bits (158), Expect = 4e-10 Identities = 109/475 (22%), Positives = 190/475 (40%), Gaps = 67/475 (14%) Query: 907 EAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966 EA L ++H + E +E ++E A++ + EE ++ ++ E+ Sbjct: 66 EAPKLKVQHKFVEEIIEETKVEDE-KSEMEEALTAI---TEELAVSMK-----EEKKEAA 116 Query: 967 EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCK 1026 E+ EE EE A ++ V T + GE E Q E +EG+ + +A Sbjct: 117 EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA---- 172 Query: 1027 EDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANAL 1086 EE +E E + E + E E + E +AE + +K + + EEV L Sbjct: 173 -----EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE--KKVEEKSEEVATKEEL 225 Query: 1087 KDEDAFKEEQKLKAEEGETETEVRAEEET-KAPPNEMGSDAENEAPVEASELSDNPGLLG 1145 + ++ +K K+ ++ E + + K+P E G ++PVE S P Sbjct: 226 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 285 Query: 1146 EDSLKETV--VPIFE--ATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSREN 1201 E+ K V P+ E +P + +E + + G GE+ ++ E K+ +E E Sbjct: 286 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ----KEEEEKEVKEAPKEEK 341 Query: 1202 RALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261 KE +D PE + K ++P EE A+ ++ E Sbjct: 342 VEKKEEKPKD------VPEKK---KAESP--------VKEEAVAEVVTITKSVKVHLE-- 382 Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQD--RNSEGDGD 1319 +E E P+ EK +E+A E EEE + + +D N E +G Sbjct: 383 ---------KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK 433 Query: 1320 MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANK 1374 E E T++ G GR V+ G + + A+E++ G + +EEK + K Sbjct: 434 EEVEQETKEK---GSGREEEKGVVTNGLDL--SPADEKK---GGDKSEEKVVVTK 480 Score = 58.5 bits (140), Expect = 5e-08 Identities = 68/333 (20%), Positives = 138/333 (41%), Gaps = 26/333 (7%) Query: 389 ERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKE- 447 + S + + A+ + S+ + +KE + EK EE + E +V ++ V E+KE Sbjct: 88 DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 147 Query: 448 --NKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVD 505 K + +E G K +G +E E ++ T E+ E Sbjct: 148 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 207 Query: 506 EEKQGEKSNEE--------GQADVQ-----MNGIPQSPLDDKKDNLDPEKESETSSQKAP 552 EEK+ E+ +EE A V+ + +P+SP+++K + P+ E K+P Sbjct: 208 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG-KSP 266 Query: 553 DARDNVKDENDG-CSESELEEDKQDMKTASSTSSRSH---PYSSDSEDESAVGDREAHTD 608 + V+++ +S +EE + + S ++ P S E +S + Sbjct: 267 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 326 Query: 609 SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENV 668 ++ + + +E E + + +P ++ E ++++ + + TK + + ++ Sbjct: 327 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV-----HL 381 Query: 669 LKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDK 701 KE E+G E EK+G +EE+ DK Sbjct: 382 EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 414 Score = 38.9 bits (89), Expect = 0.039 Identities = 60/261 (22%), Positives = 104/261 (39%), Gaps = 34/261 (13%) Query: 1284 KFREEAVDEDPEEEEDKEC----TLETE----AMQDRNSEGDGDMEGEGNTQKNEGMGGG 1335 KF EE ++E E+E E T TE +M++ E + E E ++ E Sbjct: 75 KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKK 134 Query: 1336 ---RVVAVEVLHGGGETAETAAEEREVL----AGSETAEEKTIANKASSFSDVAEEETWH 1388 + A EV GE E +E E A S+ AEE + SS + E+E Sbjct: 135 SPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGE 194 Query: 1389 QQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQE- 1447 + E G+ A A + +++ EEV EE+ +A V P E+ S + + Sbjct: 195 TEAEAEGEEAEAKE--EKKVEEKSEEVATKEEL----VADAKVEKP---EKAKSPVPKSP 245 Query: 1448 -QEEGSEGQEAATGSGDGR--------QETGAAEKFRLGLSREGERELSPESLQAMATLP 1498 +E+G + G+ +E G + + + +G+ +S ++ A P Sbjct: 246 VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSP 305 Query: 1499 VKPDFTETREKQQHMVQGESE 1519 V E + + + +GE + Sbjct: 306 VPKSPVEEAKSKAEVGKGEQK 326 Score = 38.5 bits (88), Expect = 0.050 Identities = 36/143 (25%), Positives = 57/143 (39%), Gaps = 4/143 (2%) Query: 1383 EEETWHQQDELVGKT---AAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALER 1439 E+E ++ L T A + K +E A EE P AEE V ++ V + Sbjct: 87 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA-AKKSPVKATAPEVK 145 Query: 1440 KTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPV 1499 + G +E+E E +E G+ + E G +EK EGE+E +A Sbjct: 146 EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 205 Query: 1500 KPDFTETREKQQHMVQGESETAD 1522 + + EK + + E AD Sbjct: 206 AKEEKKVEEKSEEVATKEELVAD 228 >gi|84043963 eukaryotic translation initiation factor 5B [Homo sapiens] Length = 1220 Score = 67.0 bits (162), Expect = 1e-10 Identities = 138/694 (19%), Positives = 254/694 (36%), Gaps = 122/694 (17%) Query: 420 KGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKT-----GLKEVVTAVEE 474 K +E +K++GK +KE++ ++I + +S + AQ IK +K EE Sbjct: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLE--AQGIKADRETVAVKPTENNEEE 90 Query: 475 MTSK-----GKPGQEVLEDDQEN------------TLKYEYEEDFEVDEEKQGEKSNEEG 517 TSK G+ G++ DD ++ T K + E D++ K ++ Sbjct: 91 FTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA 150 Query: 518 QADVQMNGIPQSPLDDKKDNLDPEKESE--TSSQKAPDARDNVKDENDGCSESELEEDKQ 575 + Q + ++ +DN KE SS ++ D D G +++ + Sbjct: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGP 210 Query: 576 DMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLP 635 ++++ + S + ++ ++ +RE +E A+ +E E + +K Sbjct: 211 NIESGNEDDDASFKIKTVAQKKAEKKERERK--KRDEEKAKLRKLKEKEELETGKKDQSK 268 Query: 636 IEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAE 695 +ES E+ +K V+T +P E K T ++ EG + Sbjct: 269 QKESQRKFEEETVKSKVTVDTGVIPASEE-----KAETPTAAEDDNEG-----------D 312 Query: 696 EKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINS 755 +K+KDK K E + K+KK G T+ M + A + Sbjct: 313 KKKKDKKKKKGEKEEKEKEKKKGP-------------------SKATVKAMQEALAKLKE 353 Query: 756 NKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPT 815 +E Q+ ++ E+ + +EE EA + + + Q K E + Sbjct: 354 EEERQKREEE----ERIKRLEELEAKRKEEERLEQEKRE------------------RKK 391 Query: 816 AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEA 875 ++ E E ++ ++ +R A AEA +G P SKD Sbjct: 392 QKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVP------------SKDSL 439 Query: 876 PEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEG 935 P+K+ + DK + Q LE ++ + E + T E E Sbjct: 440 PKKRPIY-----EDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEE 494 Query: 936 GVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLS 995 D G + EA E+T +E G++ I E P +E +E E Sbjct: 495 EEDTEDAGLDDWEAMASDEETEKVE--------GNKVHIEVKENPEEEEEEEEEEEEDEE 546 Query: 996 PFTGEAEASRMQVSEGSPEEGSLAKEAFLCK--EDVEGEEMVTEAEANREDDRKEILPKE 1053 E E + SEG E+ ++ E K + +EM +++E + +DDR Sbjct: 547 SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDR------- 599 Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALK 1087 +E R ++ K + K E + L+ Sbjct: 600 ---TKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630 Score = 61.6 bits (148), Expect = 6e-09 Identities = 122/562 (21%), Positives = 216/562 (38%), Gaps = 110/562 (19%) Query: 862 AAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHL----- 916 AA + G +K++ P+K + K + +Q ++ + E L+LE Sbjct: 23 AAEIEGAGAAKEQEPQKS-------KGKKKKEKKKQDFDEDDILKELEELSLEAQGIKAD 75 Query: 917 HEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKRE--------- 967 E A++ +EE G+ ++ S D D+ +ED SK + Sbjct: 76 RETVAVKPTENNEEEFTSKDKKKK--GQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEM 133 Query: 968 -DGSEEAILGGEEPAKERKEVMRTETRLSPFTGEA-------EASRMQVSEGSPEEGSLA 1019 GS++ + P K + + ++ + + E SR+ S S +E Sbjct: 134 YSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEF 193 Query: 1020 KEAFLCKEDVEGEEMVTEAEANREDDR-----KEILPKELDLA-RERRKAERPKTSLRKT 1073 ++ ++ + + E+ EDD K + K+ + RER+K + K LRK Sbjct: 194 LQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL 253 Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEV------------RAEEETKAPPNE 1121 E+EE+ KD+ KE Q+ K EE +++V +AE T A + Sbjct: 254 -KEKEELETGK--KDQSKQKESQR-KFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDN 309 Query: 1122 MGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFE--------------KSL 1167 G + + + E + + K TV + EA + K L Sbjct: 310 EGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRL 369 Query: 1168 ENITALRKEGGGERLS----EARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEP 1223 E + A RKE ERL E + + K+R+E +E + L + R+ A A + Sbjct: 370 EELEAKRKEE--ERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427 Query: 1224 AGKVQAPEG----------------LIPATGQAEELAAKDHDSCAGLEGRAEG------- 1260 A V+ P IP +++E++ + + CA +E +G Sbjct: 428 AQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS-ESMELCAAVEVMEQGVPEKEET 486 Query: 1261 ---------QGGVDVVLRTQEAVA---EEDPIMAEKFREEAVDEDPEEEEDKECTLETEA 1308 + D L EA+A E + + K E V E+PEEEE++E E + Sbjct: 487 PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIE-VKENPEEEEEEEEEEEEDE 545 Query: 1309 MQDRNSEGDGDMEGEGNTQKNE 1330 + E +G+ EG +++E Sbjct: 546 ESEEEEEEEGESEGSEGDEEDE 567 Score = 61.6 bits (148), Expect = 6e-09 Identities = 149/660 (22%), Positives = 239/660 (36%), Gaps = 89/660 (13%) Query: 473 EEMTSKGKPGQEVLEDD-QENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531 E SKGK +E + D E+ + E EE + E QG K++ E A Sbjct: 36 EPQKSKGKKKKEKKKQDFDEDDILKELEE---LSLEAQGIKADRETVAV----------- 81 Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYS 591 +N + E S+ +K + D+ND SE EDK D K+ + + YS Sbjct: 82 -KPTENNEEEFTSKDKKKKGQKGKKQSFDDND----SEELEDK-DSKSKKTAKPKVEMYS 135 Query: 592 SDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITK 651 +D+ + + + + S+E +N K K I S E E E + Sbjct: 136 GSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQ 195 Query: 652 ADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTA- 710 + K ++ N+ E G ++ K+ AE+KE+++ K EE Sbjct: 196 SRKGQKKNQKNKPGPNI-----ESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKL 250 Query: 711 -QVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTL 769 ++K+K+ LE G KD + + +ET ++ + Sbjct: 251 RKLKEKEE----LETGKKDQ-------SKQKESQRKFEEETVKSKVTVDTGVIPASEEKA 299 Query: 770 EKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA----EEF 825 E A E+D + D + KGE + + P +A A Q LA EE Sbjct: 300 ETPTAAEDDNEGDKKKKDKKKKKGEKE--EKEKEKKKGPSKA-TVKAMQEALAKLKEEEE 356 Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKD---------EAP 876 +KRE I+R E A+ + RL + + Q + L K+ EA Sbjct: 357 RQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREAR 416 Query: 877 EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGG 936 + L +L+ + L K E + + L SE E Sbjct: 417 ARAEATLKLLQAQGVEVPSKDSLPKKRPIYE----DKKRKKIPQQLESKEVSESMELCAA 472 Query: 937 VAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP 996 V V + G E+E + + EDT D EA+ EE K + E + +P Sbjct: 473 VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD-DWEAMASDEETEKVEGNKVHIEVKENP 531 Query: 997 FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056 E E + E S EE E+ EGE +E + D+ E + E D Sbjct: 532 EEEEEEEEEEEEDEESEEE-----------EEEEGE-----SEGSEGDEEDEKVSDEKDS 575 Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETK 1116 + K + S +DSE + D+D KEE+ ++ + E R E +K Sbjct: 576 GKTLDKKPSKEMS---SDSEYDS--------DDDRTKEERAY--DKAKRRIEKRRLEHSK 622 Score = 59.7 bits (143), Expect = 2e-08 Identities = 130/655 (19%), Positives = 242/655 (36%), Gaps = 93/655 (14%) Query: 507 EKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVK---DEND 563 +KQ KS + + D+ ++ + + + KE E K ++ K DE+D Sbjct: 3 KKQKNKSEDSTKDDIDLDALAA-----EIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDD 57 Query: 564 GCSE-SELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQE 622 E EL + Q +K T + + ++E+E D++ +S + S+E Sbjct: 58 ILKELEELSLEAQGIKADRETVAVKP--TENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115 Query: 623 LSEND-KPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIA 681 L + D K +K+ P E +D + K + K Sbjct: 116 LEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAK------------------------ 151 Query: 682 EGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAP 741 G ++KS K E+++D SK ++K++ E G + ++ + Sbjct: 152 -GKAQKSNKKWDGSEEDEDNSK-------KIKERSRINSSGESGDESD---EFLQSRKGQ 200 Query: 742 TMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRD---ADIVQGKGEAALW 798 N I S E K T+ +K+A +++ + RD A + + K + L Sbjct: 201 KKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEEL- 259 Query: 799 GEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDP 858 E G ++ + + E+ + + T + P E AE AE + D Sbjct: 260 -ETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDK 318 Query: 859 IGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHE 918 + K+ K + P K TV +A ++ ++ E+ E LE L Sbjct: 319 KKKKGEKEEKEKEKKKGPSKA----TVKAMQEALAKLKEEEERQKREEEERIKRLEELEA 374 Query: 919 VAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAIL--- 975 E E+ E + + E+E L+ G + + + EA L Sbjct: 375 KRKEEERLEQEKRERKK--------QKEKERKERLKKEGKLLTKSQREARARAEATLKLL 426 Query: 976 ---GGEEPAKE---RKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDV 1029 G E P+K+ +K + + + + E+ + E L + ++ V Sbjct: 427 QAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS------ESMELCAAVEVMEQGV 480 Query: 1030 -EGEEMVTEAEANREDDRKEILPKELDLA---RERRKAERPKTSLR-KTDSEREEVTRAN 1084 E EE E E+D ++ + + E K E K + K + E EE Sbjct: 481 PEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE 540 Query: 1085 ALKDEDAFKEEQK---LKAEEGETETEVRAEEET------KAPPNEMGSDAENEA 1130 +DE++ +EE++ + EG+ E E ++E+ K P EM SD+E ++ Sbjct: 541 EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDS 595 Score = 48.5 bits (114), Expect = 5e-05 Identities = 82/383 (21%), Positives = 147/383 (38%), Gaps = 30/383 (7%) Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002 G +++AS ++ + +RE + EE AK RK + E TG+ + Sbjct: 215 GNEDDDASFKIKTVAQKKAEKKERERKKRD-----EEKAKLRKLKEKEELE----TGKKD 265 Query: 1003 ASRMQVSEGSPEEGSLAKEAFL----CKEDVEGEEMVTEAEANREDDRKEILPKELDLAR 1058 S+ + S+ EE ++ + + E E T AE + E D+K+ K+ + Sbjct: 266 QSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEK 325 Query: 1059 ERRKAERPKTSLRKT-DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117 E ++ E+ K + T + +E + + ++ +EE+++K E E E + + EE + Sbjct: 326 EEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLE-ELEAKRKEEERLEQ 384 Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEG 1177 E E E E G L S +E A E +L+ + A E Sbjct: 385 EKRERKKQKEKER----KERLKKEGKLLTKSQRE-------ARARAEATLKLLQAQGVEV 433 Query: 1178 GGERLSEARDTEHKDREELSSRENRALKE-GHRQDGEGALAAPEAEPAGKVQAPEGLIPA 1236 + + ++D++ + KE + A+ E K + P + P Sbjct: 434 PSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE 493 Query: 1237 TGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEE 1296 + E A D + E G V + +E EE+ E+ +E +E+ EE Sbjct: 494 EEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEE 553 Query: 1297 E---EDKECTLETEAMQDRNSEG 1316 E E E E E + D G Sbjct: 554 EGESEGSEGDEEDEKVSDEKDSG 576 Score = 46.2 bits (108), Expect = 2e-04 Identities = 68/328 (20%), Positives = 137/328 (41%), Gaps = 32/328 (9%) Query: 404 DKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKT 463 ++K P + ++ + +G++ KK + K + E+E K E K+ + + K + QE Sbjct: 296 EEKAETPTAAEDDN--EGDKKKKDKKKKKGEKE---EKEKEKKKGPSKATVK-AMQEALA 349 Query: 464 GLKEVVTAVEEMTSKGKPGQEV--LEDDQENTLKYEYEEDFEVDEEKQGEKSNEE----- 516 LKE EE K + + + LE+ + + E E + + +KQ EK +E Sbjct: 350 KLKE-----EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKE 404 Query: 517 ------GQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL 570 Q + + L + P K+S +K P D + + ES+ Sbjct: 405 GKLLTKSQREARARAEATLKLLQAQGVEVPSKDS--LPKKRPIYEDKKRKKIPQQLESKE 462 Query: 571 EEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPR 630 + ++ A + P ++ + E D+ D+ +S +E +E + Sbjct: 463 VSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEE-TEKVEGN 521 Query: 631 KSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGK 690 K H+ ++E+ E E E++E + D E++ +E E EG+E ++ + SGK Sbjct: 522 KVHIEVKENPEEEEEEEEEEEEDEESE----EEEEEEGESEGSEGDEEDEKVSDEKDSGK 577 Query: 691 HVSAE-EKEKDKSKLWEESTAQVKDKKA 717 + + KE ++ + K+++A Sbjct: 578 TLDKKPSKEMSSDSEYDSDDDRTKEERA 605 Score = 39.7 bits (91), Expect = 0.023 Identities = 48/222 (21%), Positives = 92/222 (41%), Gaps = 52/222 (23%) Query: 404 DKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVI----------------PKRNEIKE 447 ++K K RKE+ ++G+ L K++ + R E + PK+ I E Sbjct: 388 ERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE 447 Query: 448 NKT--SVSAKFSAQEIKTGLKEVVTAVEEMTS----------------------KGKPGQ 483 +K + + ++E+ + E+ AVE M G Sbjct: 448 DKKRKKIPQQLESKEVSESM-ELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDW 506 Query: 484 EVLEDDQE------NTLKYEYEED-FEVDEEKQGEKSNEEGQADVQMNGIPQ-SPLDDKK 535 E + D+E N + E +E+ E +EE++ E+ +EE + + + G + S D++ Sbjct: 507 EAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEED 566 Query: 536 DNLDPEKESETSSQKAPD---ARDNVKDENDGCSESELEEDK 574 + + EK+S + K P + D+ D +D ++ E DK Sbjct: 567 EKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDK 608 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.305 0.125 0.340 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 62,370,281 Number of Sequences: 37866 Number of extensions: 3296965 Number of successful extensions: 25301 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 204 Number of HSP's successfully gapped in prelim test: 1291 Number of HSP's that attempted gapping in prelim test: 13142 Number of HSP's gapped (non-prelim): 8563 length of query: 1530 length of database: 18,247,518 effective HSP length: 115 effective length of query: 1415 effective length of database: 13,892,928 effective search space: 19658493120 effective search space used: 19658493120 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 43 (21.9 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.