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Search of human proteins with 76880486
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|76880486 activating signal cointegrator 1 complex subunit 3
isoform a [Homo sapiens]
(2202 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|76880486 activating signal cointegrator 1 complex subunit 3 i... 4414 0.0
gi|40217847 activating signal cointegrator 1 complex subunit 3-l... 1532 0.0
gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD prote... 1504 0.0
gi|130484567 HFM1 protein [Homo sapiens] 330 7e-90
gi|11560150 activating signal cointegrator 1 complex subunit 3 i... 158 6e-38
gi|139394648 DNA polymerase theta [Homo sapiens] 120 1e-26
gi|110556640 DNA helicase HEL308 [Homo sapiens] 114 1e-24
gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sap... 111 9e-24
gi|239745928 PREDICTED: hypothetical protein XP_002343618 [Homo ... 105 5e-22
gi|67782311 superkiller viralicidic activity 2-like homolog [Hom... 104 1e-21
gi|239756904 PREDICTED: similar to SNRNP200 protein [Homo sapiens] 97 1e-19
gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sap... 60 2e-08
gi|6005872 SEC63-like protein [Homo sapiens] 55 1e-06
gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Hom... 54 1e-06
gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo sapi... 49 4e-05
gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo sapi... 49 4e-05
gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I [... 46 4e-04
gi|74959747 Fanconi anemia, complementation group M [Homo sapiens] 45 6e-04
gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo sapi... 42 0.005
gi|116812616 RecQ protein-like 4 [Homo sapiens] 40 0.019
gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3 ... 40 0.019
gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1 [... 40 0.019
gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2 ... 40 0.019
gi|110735439 Werner syndrome protein [Homo sapiens] 40 0.033
gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent... 40 0.033
gi|148612816 RecQ protein-like 5 isoform 1 [Homo sapiens] 39 0.074
gi|51242943 RecQ protein-like 5 isoform 3 [Homo sapiens] 39 0.074
gi|51242947 RecQ protein-like 5 isoform 2 [Homo sapiens] 39 0.074
gi|149408122 RNA helicase LGP2 [Homo sapiens] 38 0.096
gi|29294649 dicer1 [Homo sapiens] 37 0.21
>gi|76880486 activating signal cointegrator 1 complex subunit 3
isoform a [Homo sapiens]
Length = 2202
Score = 4414 bits (11448), Expect = 0.0
Identities = 2202/2202 (100%), Positives = 2202/2202 (100%)
Query: 1 MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEK 60
MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEK
Sbjct: 1 MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEK 60
Query: 61 SKMQSINEDLKDILHAAKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFG 120
SKMQSINEDLKDILHAAKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFG
Sbjct: 61 SKMQSINEDLKDILHAAKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFG 120
Query: 121 PFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKNLAFSFDMHDLDHFD 180
PFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKNLAFSFDMHDLDHFD
Sbjct: 121 PFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKNLAFSFDMHDLDHFD 180
Query: 181 ELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTE 240
ELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTE
Sbjct: 181 ELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTE 240
Query: 241 VPRVEDLCCTLYDMLASIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSND 300
VPRVEDLCCTLYDMLASIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSND
Sbjct: 241 VPRVEDLCCTLYDMLASIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSND 300
Query: 301 HRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDLEV 360
HRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDLEV
Sbjct: 301 HRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDLEV 360
Query: 361 SEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIA 420
SEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIA
Sbjct: 361 SEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIA 420
Query: 421 GAKMILPEGIQRENNKLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRI 480
GAKMILPEGIQRENNKLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRI
Sbjct: 421 GAKMILPEGIQRENNKLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRI 480
Query: 481 QSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMK 540
QSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMK
Sbjct: 481 QSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMK 540
Query: 541 ALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVA 600
ALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVA
Sbjct: 541 ALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVA 600
Query: 601 LSQIVRLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATF 660
LSQIVRLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATF
Sbjct: 601 LSQIVRLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATF 660
Query: 661 LHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMV 720
LHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMV
Sbjct: 661 LHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMV 720
Query: 721 FVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFS 780
FVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFS
Sbjct: 721 FVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFS 780
Query: 781 IHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVD 840
IHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVD
Sbjct: 781 IHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVD 840
Query: 841 LGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNA 900
LGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNA
Sbjct: 841 LGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNA 900
Query: 901 EIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRK 960
EIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRK
Sbjct: 901 EIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRK 960
Query: 961 LDKAQMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEE 1020
LDKAQMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEE
Sbjct: 961 LDKAQMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEE 1020
Query: 1021 FDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSA 1080
FDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSA
Sbjct: 1021 FDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSA 1080
Query: 1081 YVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTR 1140
YVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTR
Sbjct: 1081 YVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTR 1140
Query: 1141 LEEKKLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTL 1200
LEEKKLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTL
Sbjct: 1141 LEEKKLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTL 1200
Query: 1201 SIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIF 1260
SIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIF
Sbjct: 1201 SIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIF 1260
Query: 1261 EPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEA 1320
EPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEA
Sbjct: 1261 EPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEA 1320
Query: 1321 LYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAP 1380
LYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAP
Sbjct: 1321 LYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAP 1380
Query: 1381 LKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQN 1440
LKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQN
Sbjct: 1381 LKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQN 1440
Query: 1441 RNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLA 1500
RNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLA
Sbjct: 1441 RNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLA 1500
Query: 1501 DWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLI 1560
DWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLI
Sbjct: 1501 DWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLI 1560
Query: 1561 FVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHH 1620
FVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHH
Sbjct: 1561 FVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHH 1620
Query: 1621 AGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPI 1680
AGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPI
Sbjct: 1621 AGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPI 1680
Query: 1681 TDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIA 1740
TDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIA
Sbjct: 1681 TDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIA 1740
Query: 1741 GGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYC 1800
GGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYC
Sbjct: 1741 GGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYC 1800
Query: 1801 IEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPV 1860
IEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPV
Sbjct: 1801 IEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPV 1860
Query: 1861 RHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQA 1920
RHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQA
Sbjct: 1861 RHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQA 1920
Query: 1921 LRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKP 1980
LRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKP
Sbjct: 1921 LRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKP 1980
Query: 1981 IMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGI 2040
IMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGI
Sbjct: 1981 IMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGI 2040
Query: 2041 SVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPES 2100
SVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPES
Sbjct: 2041 SVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPES 2100
Query: 2101 CAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLY 2160
CAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLY
Sbjct: 2101 CAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLY 2160
Query: 2161 FMSDCYLGLDQQYDIYLNVTQASLSAQVNTKVSDSLTDLALK 2202
FMSDCYLGLDQQYDIYLNVTQASLSAQVNTKVSDSLTDLALK
Sbjct: 2161 FMSDCYLGLDQQYDIYLNVTQASLSAQVNTKVSDSLTDLALK 2202
>gi|40217847 activating signal cointegrator 1 complex subunit 3-like 1
[Homo sapiens]
Length = 2136
Score = 1532 bits (3966), Expect = 0.0
Identities = 816/1933 (42%), Positives = 1207/1933 (62%), Gaps = 97/1933 (5%)
Query: 253 DMLASIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKK 312
++L + E +++L LLG + I+ L Q+R+ I+ L +S + ++
Sbjct: 291 EILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEK-----ER 345
Query: 313 ILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDLEVSEGLMCFDPKEL 372
I+G+ + E K L + + E++ + R E+ E V + M D + +
Sbjct: 346 IMGK---------MEADPELSKFLYQLHETEKEDLIREERSRRE--RVRQSRMDTDLETM 394
Query: 373 RIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIAGAKMILPEGIQR 432
+ + L R V D+E + + + S F+A + LP+G R
Sbjct: 395 DLDQGGEALAPRQV--------LDLEDLVFT----------QGSHFMANKRCQLPDGSFR 436
Query: 433 ENNKLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTN 492
K YEEV +P +P P EE+ + ++ L + Q F+G K LNRIQS ++ A T+
Sbjct: 437 RQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETD 496
Query: 493 ENMLICAPTGAGKTNIAMLTVLHEIRQHFQQ-GVIKKNEFKIVYVAPMKALAAEMTDYFS 551
EN+L+CAPTGAGKTN+A++ +L EI +H G I ++FKI+Y+APM++L EM F
Sbjct: 497 ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 556
Query: 552 RRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILD 611
+RL GI V ELTGD QL K EI TQ++V TPEKWD++TRK G+ +Q+VRL+ILD
Sbjct: 557 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKG-GERTYTQLVRLIILD 615
Query: 612 EVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFF 671
E+HLLH+DRGPVLE++VAR +R +E TQ +R++GLSATLPNY DVATFL V+P GLF+
Sbjct: 616 EIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFY 675
Query: 672 FDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHARNATVRT 731
FD FRPVPL QT++GI +++ M+E+ YE +++ +QV+VFVH+R T +T
Sbjct: 676 FDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHA-GKNQVLVFVHSRKETGKT 734
Query: 732 AMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDR 791
A ++ + + F + + ++ +N ++++L P GF+IHHAGM R DR
Sbjct: 735 ARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDR 794
Query: 792 NLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFG 851
LVE+LF++ HI+VLV TATLAWGVNLPAH VIIKGTQ+Y+ ++G + +LG LD++Q+ G
Sbjct: 795 TLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLG 854
Query: 852 RAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNAEIALGTVTNVE 911
RAGRPQ+D GEGI+IT+H +L +YL+LL Q+ PIESQ + L D LNAEI LG V N +
Sbjct: 855 RAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAK 914
Query: 912 EAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEE 971
+AV W+ Y YLY+RM +P YGISH + DP L + R LV LDK ++++++
Sbjct: 915 DAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDK 974
Query: 972 RTGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEI 1031
+TG F T+LGR ASHYYI +T++T+N+L +E ++F + S + EF I VREEE
Sbjct: 975 KTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEK 1034
Query: 1032 EELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVR 1091
EL LL + +E KIN+LLQ +IS+ +++ F+L++D YV Q+A R++R
Sbjct: 1035 LELQKLLERV-PIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMR 1093
Query: 1092 ALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKL 1151
A+FEI L + W +T + LNL K+IDKR+W PLRQF LP ++ ++E+K ++L
Sbjct: 1094 AIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERL 1153
Query: 1152 KDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQ 1211
D+ +EIG ++ +G + + VH P + + +QPITR+ L+V L+I DF W+++
Sbjct: 1154 YDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEK 1213
Query: 1212 VHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIFEPLPSQYYIRA 1271
VHG+ E +WI VED ++ I H EYFL K +++ L+ F +P+FEPLP QY+IR
Sbjct: 1214 VHGS-SEAFWILVEDVDSEVILHHEYFLLKAKY--AQDEHLITFFVPVFEPLPPQYFIRV 1270
Query: 1272 VSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYN--FSHFNP 1329
VSDRWL E ++F+HLILPE++PP TELLDLQPLP++AL A+E+LY F FNP
Sbjct: 1271 VSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNP 1330
Query: 1330 VQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERM 1389
+QTQ+F+T+Y++D NV +GAPTGSGKT+ AE AI R+ + + VYI P++AL +
Sbjct: 1331 IQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQVY 1390
Query: 1390 DDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTI 1449
DW + +++L KKV+ LTG+ + D+K + K ++I++TPEKWD +SR W+ R VQ + +
Sbjct: 1391 MDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINL 1450
Query: 1450 LIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMG 1509
++DE+HL+G E GPVLEVI SR +ISS E+P+RIV LS++L+NA+D+A WL
Sbjct: 1451 FVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATS 1510
Query: 1510 LFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTR 1569
FNF P+VRPVPLE+HIQGF H R+ SM KP + AI HSP KPV++FV SR+QTR
Sbjct: 1511 TFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVIVFVPSRKQTR 1570
Query: 1570 LTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRK 1629
LTA++++ A + +++L+ E+++ + + DS LK TL G+G H GL +R+
Sbjct: 1571 LTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERR 1630
Query: 1630 TVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGR 1689
VE+LF + +QV++A+ +L WG+N AHLVII T+YY+GK YVD+PI DVLQM+G
Sbjct: 1631 LVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGH 1690
Query: 1690 AGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQD 1749
A RP DD+G+ VI+ KKDF+KKFLYEP PVES L + DH NAEI TI +KQD
Sbjct: 1691 ANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQD 1750
Query: 1750 ALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRS 1809
A+DY+TWT+ +RR+ NP+YYNL +SH ++ LS L+E++L +LE S CI I ED
Sbjct: 1751 AVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISI-EDEMD 1809
Query: 1810 IEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNS 1869
+ PL G IA+YYY+ + T+++F L + L+ I+S+A EY ++P+RH+ED++
Sbjct: 1810 VAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLR 1869
Query: 1870 ELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLD 1929
+LA+ +P + N F+ PH K +LLLQAHLSR L + +DT+ +L +A+R+ QA +D
Sbjct: 1870 QLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSA-ELQSDTEEILSKAIRLIQACVD 1928
Query: 1930 VAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARG 1989
V ++ GWL L L QMV Q W KDS L LP+ + H+ K +G
Sbjct: 1929 VLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHI----------KRCTDKG 1978
Query: 1990 RTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDL 2049
S+ + E+ +D ++++ +L ++ F + P I
Sbjct: 1979 VESVFDIMEM------EDEERNALL--QLTDSQIADVARFCNRYPNI------------- 2017
Query: 2050 VEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPK 2109
ELS + D + + V+ V L+R + + + P FP+
Sbjct: 2018 -----ELSYEVVDKD--------SIRSGGPVVVLVQLER------EEEVTGPVIAPLFPQ 2058
Query: 2110 SKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGL 2169
++EGW++++G+ LI++KR+ ++ L F P G + YTLYFMSD Y+G
Sbjct: 2059 KREEGWWVVIGDAKSNSLISIKRL-TLQQKAKVKLDFVAP-ATGAHNYTLYFMSDAYMGC 2116
Query: 2170 DQQYDIYLNVTQA 2182
DQ+Y ++V +A
Sbjct: 2117 DQEYKFSVDVKEA 2129
>gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD protein,
partial [Homo sapiens]
Length = 1700
Score = 1504 bits (3895), Expect = 0.0
Identities = 777/1750 (44%), Positives = 1129/1750 (64%), Gaps = 63/1750 (3%)
Query: 436 KLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENM 495
K YEEV +P +P P EE+ + ++ L + Q F+G K LNRIQS ++ A T+EN+
Sbjct: 4 KGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENL 63
Query: 496 LICAPTGAGKTNIAMLTVLHEIRQHFQQ-GVIKKNEFKIVYVAPMKALAAEMTDYFSRRL 554
L+CAPTGAGKTN+A++ +L EI +H G I ++FKI+Y+APM++L EM F +RL
Sbjct: 64 LLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRL 123
Query: 555 EPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVH 614
GI V ELTGD QL K EI TQ++V TPEKWD++TRK G+ +Q+VRL++LDE+H
Sbjct: 124 ATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKG-GERTYTQLVRLIVLDEIH 182
Query: 615 LLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDG 674
LLH+DRGPVLE++VAR +R +E TQ +R++GLSATLPNY DVATFL V+P GLF+FD
Sbjct: 183 LLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDN 242
Query: 675 RFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHARNATVRTAMS 734
FRPVPL QT++GI +++ M+E+ YE +++ +QV+VFVH+R T +TA +
Sbjct: 243 SFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHA-GKNQVLVFVHSRKETGKTARA 301
Query: 735 LIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLV 794
+ + + F + + ++ +N ++++L P GF+IHHAGM R DR LV
Sbjct: 302 IRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLV 361
Query: 795 ENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAG 854
E+LF + HI+VLV TATLAWGVNLPAH VIIKGTQ+Y+ ++G + +LG LD++Q+ GRAG
Sbjct: 362 EDLFGDKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAG 421
Query: 855 RPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNAEIALGTVTNVEEAV 914
RPQ+D GEGI+IT+H +L +YL+LL Q+ PIESQ + L D LNAEI LG V N ++AV
Sbjct: 422 RPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAV 481
Query: 915 KWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTG 974
W+ Y YLY+RM +P YGISH + DP L + R LV LDK +++++++TG
Sbjct: 482 NWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTG 541
Query: 975 YFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEEL 1034
F T+LGR ASHYYI +T++T+N+L +E ++F + S + EF I VREEE EL
Sbjct: 542 NFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLEL 601
Query: 1035 DTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALF 1094
LL + +E KIN+LLQ +IS+ +++ F+L++D YV Q+A R++RA+F
Sbjct: 602 QKLLERV-PIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIF 660
Query: 1095 EIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKLKDM 1154
EI L + W +T + LNL K+IDKR+W PLRQF LP ++ ++E+K ++L D+
Sbjct: 661 EIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDL 720
Query: 1155 RKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHG 1214
+EIG ++ +G + + VH P + + +QPITR+ L+V L+I DF W+++VHG
Sbjct: 721 NHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHG 780
Query: 1215 TVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIFEPLPSQYYIRAVSD 1274
+ E +WI VED ++ I H EYFL K +++ L+ F +P+FEPLP QY+IR VSD
Sbjct: 781 S-SEAFWILVEDVDSEVILHHEYFLLKAKY--AQDEHLITFFVPVFEPLPPQYFIRVVSD 837
Query: 1275 RWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYN--FSHFNPVQT 1332
RWL E ++F+HLILPE++PP TELLDLQPLP++AL A+E+LY F FNP+QT
Sbjct: 838 RWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQT 897
Query: 1333 QIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDW 1392
Q+F+T+Y++D NV +GAPTGSGKT+ AE AI R+ + + VYI P++ + DW
Sbjct: 898 QVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITPMRLWQEQVYMDW 957
Query: 1393 KVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILII 1452
+ +++L KKV+ LTG+ + D+K + K ++I++TPEKWD +SR W+ R VQ + + ++
Sbjct: 958 YEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVV 1017
Query: 1453 DEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFN 1512
DE+HL+G E GPVLEVI SR +ISS E+P+RIV LS++L+NA+D+A WL FN
Sbjct: 1018 DEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLGCSATSTFN 1077
Query: 1513 FRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTA 1572
F P+VRPVPLE+HIQGF H R+ SM KP F AI HSP KPV++FV SR+QTRLTA
Sbjct: 1078 FHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVFHAITKHSPKKPVIVFVPSRKQTRLTA 1137
Query: 1573 LELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVE 1632
++++ A + +++L+ E+++ + + DS LK TL G+G H GL +R+ VE
Sbjct: 1138 IDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVE 1197
Query: 1633 ELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGR 1692
+LF + +QV++A+ +L WG+N AHLVII T YY+GK YVD+PI DVLQM+G A R
Sbjct: 1198 QLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANR 1257
Query: 1693 PQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALD 1752
P DD+G+ VI+ KKDF+KKFLYEP PVES L + DH NAEI TI +KQDA+D
Sbjct: 1258 PLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVD 1317
Query: 1753 YITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEP 1812
Y+TWT+ +RR+ NP+YYNL +SH ++ LS L+E++L +LE S CI I ED + P
Sbjct: 1318 YLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISI-EDEMDVAP 1376
Query: 1813 LTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELA 1872
L G IA+YYY+ + T+++F L + L+ I+S+A EY ++P+RH+ED++ +LA
Sbjct: 1377 LNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLA 1436
Query: 1873 KCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAA 1932
+ +P + N F+ PH K +LLLQAHLSR L + +DT+ +L +A+R+ QA +DV +
Sbjct: 1437 QKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSA-ELQSDTEEILSKAIRLIQACVDVLS 1495
Query: 1933 NQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTS 1992
+ GWL L L QMV Q W +DS L LP + LFK+ KG
Sbjct: 1496 SNGWLSPALAAMELAQMVTQAMWSEDSYLRRLPPFPS---GLFKRCTD--KG-------- 1542
Query: 1993 IESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEG 2052
+ES+ +++ + + + +S++ F + P I
Sbjct: 1543 VESVFDIMEMEDEERNALLQLTDSQI-----ADVARFCNRYPNI---------------- 1581
Query: 2053 HNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKD 2112
ELS + D + + V+ V L+R + + + P FP+ ++
Sbjct: 1582 --ELSYEVVDKD--------SIRSGGPVVVLVQLER------EEEVTGPVIAPLFPQKRE 1625
Query: 2113 EGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLDQQ 2172
EGW++++G+ LI++KR+ ++ L F P GR+ TLYFMSD Y+G DQ+
Sbjct: 1626 EGWWVVIGDAKSNSLISIKRL-TLQQKAKVKLDFVAPATGGRH-NTLYFMSDAYMGCDQE 1683
Query: 2173 YDIYLNVTQA 2182
Y ++V +A
Sbjct: 1684 YKFSVDVKEA 1693
>gi|130484567 HFM1 protein [Homo sapiens]
Length = 1435
Score = 330 bits (847), Expect = 7e-90
Identities = 231/664 (34%), Positives = 355/664 (53%), Gaps = 47/664 (7%)
Query: 1310 ITALGCKAYEALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNK 1369
+T + K F +FN +Q++ F L +TD N ++ APTGSGKTV ELAI R+ +
Sbjct: 264 VTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLME 323
Query: 1370 YPTS----KAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGD-VTPDMKSIAKADLI 1424
P K VY+AP+KAL +R DDWK + +G ELTGD V D+ I A +I
Sbjct: 324 VPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGP-IGLNCKELTGDTVMDDLFEIQHAHII 382
Query: 1425 VTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGEE-RGPVLEVIVSRTNFISS----- 1478
+TTPEKWD ++R W++ + VQ V + +IDE+H++ +E RGP LEV+VSR + S
Sbjct: 383 MTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTL 442
Query: 1479 ---HTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFR--PSVRPVPLEVHIQGFP--- 1530
T P+R V +S + NA D+A+WL+ + + S RPV L+ + GFP
Sbjct: 443 KNTSTAIPMRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSS 502
Query: 1531 GQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLN 1590
Q ++N I+ +S KP L+F ++R+ + A L+ +D K +
Sbjct: 503 NQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLV------KDAKFIMT 556
Query: 1591 MDERE-MENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTL 1649
+++++ ++ +VRDS L+ L G HHAG+ DRK VE F + VL TSTL
Sbjct: 557 VEQKQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTL 616
Query: 1650 AWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIK 1709
A GVN PAHLV+IK T +Y G + ++ TD+LQM+GRAGRPQFD AVI+
Sbjct: 617 AMGVNLPAHLVVIKSTMHYAGGL--FEEYSETDILQMIGRAGRPQFDTTATAVIMTRLST 674
Query: 1710 KDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSY 1769
+D Y + L VESSL L +HLNAEI TIT A+++I T + R + NPS+
Sbjct: 675 RDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSH 734
Query: 1770 YNLGD-VSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQT 1828
Y ++ D + L L K+L +L I++ ++ + +P GR+ ++YY+ +T
Sbjct: 735 YGFASGLNKDGIEAKLQELCLKNLNDLSSLDLIKM-DEGVNFKPTEAGRLMAWYYITFET 793
Query: 1829 VKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAK-------CLPIESNP 1881
VK F + + + +L+++++ +E+ D+ +R NE + L K P+E
Sbjct: 794 VKKFY-TISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPNRITIRFPMEGR- 851
Query: 1882 HSFDSPHTKAHLLLQAHLSRAMLPCPDY--DTDTKTVLDQALRVCQAMLD-VAANQGWLV 1938
+ K + L+QA L +P D+ DT + R+ + + D VAA +
Sbjct: 852 --IKTREMKVNCLIQAQL--GCIPIQDFALTQDTAKIFRHGSRITRWLSDFVAAQEKKFA 907
Query: 1939 TVLN 1942
+LN
Sbjct: 908 VLLN 911
Score = 318 bits (816), Expect = 3e-86
Identities = 243/756 (32%), Positives = 387/756 (51%), Gaps = 66/756 (8%)
Query: 471 FKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNE 530
FK N IQS F+ T+ N +ICAPTG+GKT + L + + + +
Sbjct: 275 FKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLL----MEVPLPWLN 330
Query: 531 FKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKS-EILRTQMLVTTPEKWD 589
KIVY+AP+KAL ++ D + + P+G+ KELTGD + EI +++TTPEKWD
Sbjct: 331 IKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWD 390
Query: 590 VVTRKSVGDVALSQIVRLLILDEVHLLH-EDRGPVLESIVAR--TLRQVE------STQS 640
+TRK D +L Q+VRL ++DEVH++ E+RGP LE +V+R T++ V ST
Sbjct: 391 SMTRKW-RDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAI 449
Query: 641 MIRILGLSATLPNYLDVATFLH--VNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLN 698
+R + +SAT+PN D+A +L P + L D RPV L + LG C++ +
Sbjct: 450 PMRFVAVSATIPNAEDIAEWLSDGERPAVCLKM-DESHRPVKLQKVVLGFPCSSNQTEFK 508
Query: 699 NMDEVCYE--NVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDY 756
+ Y+ +V++ +VF R + A L++ AK F T
Sbjct: 509 FDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAK-------FIMTVEQKQ 561
Query: 757 VLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGV 816
L +K R+ ++R++ DG + HHAGM DR +VE F+ G + VL T+TLA GV
Sbjct: 562 RL-QKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGV 620
Query: 817 NLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHY 876
NLPAH V+IK T YA G F + D++Q+ GRAGRPQFD +I+T Y
Sbjct: 621 NLPAHLVVIKSTMHYAG--GLFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRDKY 678
Query: 877 LTLLTQRNPIESQFLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGIS 936
+ +L R+ +ES L ++LNAEI L T+T+V AV+WI T LY+R NP YG +
Sbjct: 679 IQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYGFA 738
Query: 937 HKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTGYFSSTDLGRTASHYYIKYNTIE 996
+ + ++L ++ L +I+ +E F T+ GR + YYI + T++
Sbjct: 739 SGLNK--DGIEAKLQELCLKNLNDLSSLDLIKMDEGVN-FKPTEAGRLMAWYYITFETVK 795
Query: 997 TFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLS--NFCELSTP--GGVEN 1052
F + +T D+ +++ +EF I++R E + L+TL N + P G ++
Sbjct: 796 KFYTI-SGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPNRITIRFPMEGRIKT 854
Query: 1053 SYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRAL--FEIALRKRWPTMTYRLL 1110
K+N L+Q + + F+L D+A + ++ +RI R L F A K++ + L+
Sbjct: 855 REMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVAAQEKKFAVLLNSLI 914
Query: 1111 NLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVD------------KLKDMRKDE 1158
L+K +LW + S+ H+ +LE+ +T+ K+++ E
Sbjct: 915 -LAKCFRCKLW-------ENSL---HVSKQLEKIGITLSNAIVNAGLTSFKKIEETDARE 963
Query: 1159 IGHILH-HVNIGLKVKQCVHQIPSVMMEASIQPITR 1193
+ IL+ H G ++K+ V +P E ++ ITR
Sbjct: 964 LELILNRHPPFGTQIKETVMYLPK--YELKVEQITR 997
>gi|11560150 activating signal cointegrator 1 complex subunit 3
isoform b [Homo sapiens]
Length = 111
Score = 158 bits (399), Expect = 6e-38
Identities = 80/80 (100%), Positives = 80/80 (100%)
Query: 1 MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEK 60
MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEK
Sbjct: 1 MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEK 60
Query: 61 SKMQSINEDLKDILHAAKQI 80
SKMQSINEDLKDILHAAKQI
Sbjct: 61 SKMQSINEDLKDILHAAKQI 80
>gi|139394648 DNA polymerase theta [Homo sapiens]
Length = 2590
Score = 120 bits (302), Expect = 1e-26
Identities = 123/466 (26%), Positives = 213/466 (45%), Gaps = 68/466 (14%)
Query: 1344 NVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKK 1403
N++ APT +GKT+ AEL I + + KA++I P ++ +E+ + +E +G K
Sbjct: 110 NLVYSAPTSAGKTLVAELLILKRVLEM-RKKALFILPFVSVAKEKKYYLQSLFQE-VGIK 167
Query: 1404 VIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGE-ER 1462
V G +P + + D+ V T E+ +G+ N + + ++++DE+H+LG+ R
Sbjct: 168 VDGYMGSTSPS-RHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHR 226
Query: 1463 GPVLEVIVSRTNFI-----------SSHTEKPVRIVGLSTALANARDLADWLNIKQMGLF 1511
G +LE+++++ +I +S V+IVG+S L N +A WLN +
Sbjct: 227 GYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAEL---- 282
Query: 1512 NFRPSVRPVPLEVHIQ-GFPGQHYCPRMASMNKPAFQ-----------AIRSHSPAKPVL 1559
+ RPVPL ++ G ++ +P Q + VL
Sbjct: 283 -YHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVL 341
Query: 1560 IFVSSRRQTRLTALELIA------------FLATEEDPKQWLNMDEREMENIIATVR--- 1604
+F S++ A ++IA + E P + ++++E+ ++ +R
Sbjct: 342 LFCPSKKWCEKLA-DIIAREFYNLHHQAEGLVKPSECPP--VILEQKELLEVMDQLRRLP 398
Query: 1605 ---DSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVI 1661
DS L+ T+ +G+ HHAGL +R +E F ++VL ATSTL+ GVN PA VI
Sbjct: 399 SGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVI 458
Query: 1662 IKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPF 1721
I+ T + G+ I QM+GRAGR D G+++++ + +K L
Sbjct: 459 IR-TPIFGGR-----PLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSL 512
Query: 1722 -PVESSL--------LGVLSDHLNAEIAGGTITSKQDALDYITWTY 1758
PV S L G + + I GG ++ QD Y T+
Sbjct: 513 KPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTF 558
Score = 120 bits (300), Expect = 2e-26
Identities = 118/431 (27%), Positives = 203/431 (47%), Gaps = 74/431 (17%)
Query: 493 ENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSR 552
+N++ APT AGKT +A L +L + + ++K K +++ P ++A E Y
Sbjct: 109 KNLVYSAPTSAGKTLVAELLILKRVLE------MRK---KALFILPFVSVAKEKKYYLQS 159
Query: 553 RLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDE 612
+ +GI V G S+ + V T E+ + + + + + + ++ ++++DE
Sbjct: 160 LFQEVGIKVDGYMGSTSPSR-HFSSLDIAVCTIERANGLINRLIEENKMD-LLGMVVVDE 217
Query: 613 VHLLHED-RGPVLESIVARTL---RQVESTQS--------MIRILGLSATLPNYLDVATF 660
+H+L + RG +LE ++ + R+ S Q+ ++I+G+SATLPN VA++
Sbjct: 218 LHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASW 277
Query: 661 LHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANK---------------MQQLNNMDEV-- 703
L+ Y FRPVPL ++ +K N +Q + D V
Sbjct: 278 LNAELY------HTDFRPVPLLES---VKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVS 328
Query: 704 -CYENVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNCGHIP--FFFPTQGHDYVLAE 760
CYE + H V++F ++ + A + N H P++ +L +
Sbjct: 329 LCYETICDN----HSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQ 384
Query: 761 KQVQRSRNKQVREL-----------FPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCT 809
K++ + Q+R L P G + HHAG+ ++R+++E F G I+VL T
Sbjct: 385 KELLEVMD-QLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAAT 443
Query: 810 ATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITT 869
+TL+ GVNLPA VII+ T I+ + L IL Q+ GRAGR D GE I+I
Sbjct: 444 STLSSGVNLPARRVIIR-TPIFGGR-----PLDILTYKQMVGRAGRKGVDTVGESILICK 497
Query: 870 HDKLSHYLTLL 880
+ + S + LL
Sbjct: 498 NSEKSKGIALL 508
>gi|110556640 DNA helicase HEL308 [Homo sapiens]
Length = 1101
Score = 114 bits (284), Expect = 1e-24
Identities = 139/572 (24%), Positives = 240/572 (41%), Gaps = 89/572 (15%)
Query: 453 FEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFE-TAYNTNENMLICAPTGAGKTNIAML 511
F P ++DL FKG+++L Q + +N++ PT GKT +A +
Sbjct: 316 FYSLPSKVRDL----YAQFKGIEKLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEI 371
Query: 512 TVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLS 571
+L E+ +K+ ++ + P A+ E S LG V+E G S
Sbjct: 372 LMLQELL------CCRKD---VLMILPYVAIVQEKISGLSSFGIELGFFVEEYAG----S 418
Query: 572 KSEILRTQ------MLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVHLLHE-DRGPVL 624
K T+ + + T EK + + + + L+++DE+H++ E RG L
Sbjct: 419 KGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRIDSL-GLVVVDELHMIGEGSRGATL 477
Query: 625 ESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRPVPLGQT 684
E +A+ L ++TQ I+G+SATL N D+ FL ++ +FRPV L +
Sbjct: 478 EMTLAKILYTSKTTQ----IIGMSATLNNVEDLQKFLQAE------YYTSQFRPVELKEY 527
Query: 685 F--------LGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHARNATVRTAMSLI 736
+ K N M + + Y + LK++ H V + + +
Sbjct: 528 LKINDTIYEVDSKAENGMT-FSRLLNYKYSDTLKKMDPDHLVALVTEV--IPNYSCLVFC 584
Query: 737 ERAKNCGHIPFFFPTQGHDYVLAEKQVQRS---RNKQ----------VRELFPDGFSIHH 783
KNC ++ L K+ ++ +N + ++ P G + HH
Sbjct: 585 PSKKNCENVAEMICKFLSKEYLKHKEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHH 644
Query: 784 AGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGI 843
+G+ +R L+E +S G + + CT+TLA GVNLPA VI++ Y AK L
Sbjct: 645 SGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAP--YVAKE----FLKR 698
Query: 844 LDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIES-------QFLESLAD 896
Q+ GRAGR D GE I+I L L+T+ P+E+ +F + +
Sbjct: 699 NQYKQMIGRAGRAGIDTIGESILILQEKDKQQVLELITK--PLENCYSHLVQEFTKGIQT 756
Query: 897 NLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIE 956
+ I L TN+++ +++ T+ +G+ K + +L + + +
Sbjct: 757 LFLSLIGLKIATNLDDIYHFMNGTF-----------FGVQQKVLLKEKSLWEITVESLRY 805
Query: 957 VGRK--LDKAQMIRFEERTGY-FSSTDLGRTA 985
+ K L K + + EE Y F T LGR +
Sbjct: 806 LTEKGLLQKDTIYKSEEEVQYNFHITKLGRAS 837
Score = 113 bits (283), Expect = 2e-24
Identities = 127/520 (24%), Positives = 221/520 (42%), Gaps = 68/520 (13%)
Query: 1316 KAYEALYNFSH----FNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYP 1371
K E LY + H N VQ + N++ PT GKT+ AE+ + +
Sbjct: 331 KGIEKLYEWQHTCLTLNSVQERK---------NLIYSLPTSGGKTLVAEILMLQEL-LCC 380
Query: 1372 TSKAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDVT--PDMKSIAKADLIVTTPE 1429
+ I P A+V+E++ +LG V E G P K K L + T E
Sbjct: 381 RKDVLMILPYVAIVQEKISGLS-SFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIATIE 439
Query: 1430 KWDGVSRSWQNRNYVQQVTILIIDEIHLLGE-ERGPVLEVIVSRTNFISSHTEKPVRIVG 1488
K + S + + ++++DE+H++GE RG LE+ +++ + T K +I+G
Sbjct: 440 KGHSLVNSLIETGRIDSLGLVVVDELHMIGEGSRGATLEMTLAKILY----TSKTTQIIG 495
Query: 1489 LSTALANARDLADWLNIKQMGLFNFRP-------SVRPVPLEVHIQGFPGQ--------H 1533
+S L N DL +L + FRP + EV + G
Sbjct: 496 MSATLNNVEDLQKFLQAEYY-TSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYK 554
Query: 1534 YCPRMASMNKPAFQAIRSHS-PAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMD 1592
Y + M+ A+ + P L+F S++ A + FL+ K++L
Sbjct: 555 YSDTLKKMDPDHLVALVTEVIPNYSCLVFCPSKKNCENVAEMICKFLS-----KEYLKHK 609
Query: 1593 EREMENIIATVRDSN-------LKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIA 1645
E+E +I +++ LK T+ FG+ HH+GL +RK +EE + + +
Sbjct: 610 EKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTC 669
Query: 1646 TSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILV 1705
TSTLA GVN PA VI++ +R QM+GRAGR D G++++++
Sbjct: 670 TSTLAAGVNLPARRVILRAPYVAKEFLKR------NQYKQMIGRAGRAGIDTIGESILIL 723
Query: 1706 HDIKKDFYKKFLYEPFP------VESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYF 1759
+ K + + +P V+ G+ + L+ I T+ D ++ T+F
Sbjct: 724 QEKDKQQVLELITKPLENCYSHLVQEFTKGIQTLFLSL-IGLKIATNLDDIYHFMNGTFF 782
Query: 1760 FRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSY 1799
+ + +L +++ +S L +L EK L++ + Y
Sbjct: 783 GVQQKVLLKEKSLWEITVES----LRYLTEKGLLQKDTIY 818
>gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sapiens]
Length = 1042
Score = 111 bits (277), Expect = 9e-24
Identities = 118/417 (28%), Positives = 186/417 (44%), Gaps = 84/417 (20%)
Query: 1344 NVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKK 1403
+VL+ A T +GKTV AE AI + + ++ +P+KAL ++ + ++
Sbjct: 156 SVLVSAHTSAGKTVCAEYAIALALRE--KQRVIFTSPIKALSNQKYREMYEEFQD----- 208
Query: 1404 VIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRS--WQNRNYVQQVTILIIDEIHLLGE- 1460
V +TGDVT + A +V T E + RS ++ +++V +I DEIH + +
Sbjct: 209 VGLMTGDVTIN----PTASCLVMTTE----ILRSMLYRGSEVMREVAWVIFDEIHYMRDS 260
Query: 1461 ERGPVLE--VIVSRTNFISSHTEKPVRIVGLSTALANARDLADWL-NIKQMGLFNFRPSV 1517
ERG V E +I+ N V V LS + NAR A+W+ ++ +
Sbjct: 261 ERGVVWEETIILLPDN---------VHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDY 311
Query: 1518 RPVPLEVHI--QGFPGQHYCP------RMASMNKPAFQAIR----------------SHS 1553
RP PL+ +I G G H R + N A Q +R +
Sbjct: 312 RPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNT-AMQVLRDAGDLAKGDQKGRKGGTKG 370
Query: 1554 PA--------------KPVLIFVSSRRQTRLTALELIAF-LATEEDPKQWLNMDEREMEN 1598
P+ +PV+IF S++ AL++ T+E+ K M E N
Sbjct: 371 PSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKK----MVEEVFSN 426
Query: 1599 IIATVRDSNLKLT--------LAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLA 1650
I + D + KL L GIG+HH GL ++T+E LF ++ L AT T A
Sbjct: 427 AIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFA 486
Query: 1651 WGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHD 1707
G+N PA V+ +DGK R++ + +QM GRAGR DD+G +++V +
Sbjct: 487 MGINMPARTVLFTNARKFDGKDFRWIS--SGEYIQMSGRAGRRGMDDRGIVILMVDE 541
Score = 77.0 bits (188), Expect = 2e-13
Identities = 105/457 (22%), Positives = 185/457 (40%), Gaps = 85/457 (18%)
Query: 490 NTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDY 549
+ N+++L+ A T AGKT A + +R+ + ++++ +P+KAL+ +
Sbjct: 152 DNNQSVLVSAHTSAGKTVCAEYAIALALRE----------KQRVIFTSPIKALSNQKYRE 201
Query: 550 FSRRLEPLGIIVKELTGDMQLSKSE---ILRTQMLVTTPEKWDVVTRKSVGDVALSQIVR 606
+ +G+ +TGD+ ++ + ++ T++L + + V R+ V
Sbjct: 202 MYEEFQDVGL----MTGDVTINPTASCLVMTTEILRSMLYRGSEVMRE----------VA 247
Query: 607 LLILDEVHLLHE-DRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATF---LH 662
+I DE+H + + +RG V E + + + LSAT+PN A + LH
Sbjct: 248 WVIFDEIHYMRDSERGVVWEETIILL-------PDNVHYVFLSATIPNARQFAEWICHLH 300
Query: 663 VNP---------------YIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCY-- 705
P YI DG V F MQ L + ++
Sbjct: 301 KQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGD 360
Query: 706 -----------ENVLKQVKAGHQ-----VMVFVHARNATVRTAMSLIERAKNCGHIPFFF 749
NV K VK + V++F ++ A+ + + N
Sbjct: 361 QKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMV 420
Query: 750 PTQGHDYV--LAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLV 807
+ + L+++ + + + V L G IHH G+L + +E LFS G IK L
Sbjct: 421 EEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALF 480
Query: 808 CTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIII 867
T T A G+N+PA V+ + + K ++ G + +Q+ GRAGR D G +I+
Sbjct: 481 ATETFAMGINMPARTVLFTNARKFDGKDFRWISSG--EYIQMSGRAGRRGMDDRGI-VIL 537
Query: 868 TTHDKLSHYLTLLTQRNPIESQFLESLADNLNAEIAL 904
+K+S I Q L+ AD LN+ L
Sbjct: 538 MVDEKMS---------PTIGKQLLKGSADPLNSAFHL 565
>gi|239745928 PREDICTED: hypothetical protein XP_002343618 [Homo
sapiens]
Length = 299
Score = 105 bits (262), Expect = 5e-22
Identities = 53/135 (39%), Positives = 83/135 (61%), Gaps = 1/135 (0%)
Query: 1838 PECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQA 1897
P L+ I+S+A Y ++P++H+E++ +LA+ +P + N F+ PH K +LLLQA
Sbjct: 53 PRTKVRGLIEIISNAAGYENIPIQHHEENFLRQLAQKVPDKLNNPKFNDPHIKTNLLLQA 112
Query: 1898 HLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLK 1957
HLSR L + +DT+ +L +A+R+ QA +DV ++ GWL + L L QMV Q W K
Sbjct: 113 HLSRMQLSA-ELQSDTEEILSKAVRLVQACVDVLSSNGWLSSALAAMELAQMVTQAMWSK 171
Query: 1958 DSSLLTLPNIENHHL 1972
DS L LP+ + H+
Sbjct: 172 DSYLKQLPHFISEHI 186
Score = 58.5 bits (140), Expect = 7e-08
Identities = 27/72 (37%), Positives = 45/72 (62%), Gaps = 2/72 (2%)
Query: 2111 KDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLD 2170
++EGW++++G+ LI++KR+ ++ L F P G + YTLYFMSD Y+G D
Sbjct: 223 REEGWWVVIGDTKSNSLISIKRL-ILQQKAKVKLDFVAPAT-GAHNYTLYFMSDAYMGCD 280
Query: 2171 QQYDIYLNVTQA 2182
Q+Y ++V +A
Sbjct: 281 QEYKFSMDVKEA 292
Score = 48.1 bits (113), Expect = 9e-05
Identities = 35/154 (22%), Positives = 71/154 (46%), Gaps = 2/154 (1%)
Query: 1011 IFAIVSKAEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEM 1070
+ I+S A ++ I ++ E L L + + + K N+LLQ ++SR ++
Sbjct: 60 LIEIISNAAGYENIPIQHHEENFLRQLAQKVPDKLNNPKFNDPHIKTNLLLQAHLSRMQL 119
Query: 1071 DSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQF 1130
S L SD+ + A R+V+A ++ W + + L++++ + +W S L+Q
Sbjct: 120 -SAELQSDTEEILSKAVRLVQACVDVLSSNGWLSSALAAMELAQMVTQAMWSKDSYLKQL 178
Query: 1131 -SILPPHILTRLEEKKLTVDKLKDMRKDEIGHIL 1163
+ HI ++ +V + +M +E IL
Sbjct: 179 PHFISEHIKRCTDKGVKSVFDIMEMEDEERNTIL 212
>gi|67782311 superkiller viralicidic activity 2-like homolog [Homo
sapiens]
Length = 1246
Score = 104 bits (259), Expect = 1e-21
Identities = 112/419 (26%), Positives = 186/419 (44%), Gaps = 85/419 (20%)
Query: 1344 NVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKK 1403
+V + A T +GKTV AE AI + K+ T + +Y +P+KAL ++ D++ +
Sbjct: 327 SVFVAAHTSAGKTVVAEYAI-ALAQKHMT-RTIYTSPIKALSNQKFRDFRNTFGD----- 379
Query: 1404 VIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRS--WQNRNYVQQVTILIIDEIHLLGE- 1460
G +T D++ +A ++ T E + RS + + ++ + +I DE+H + +
Sbjct: 380 ----VGLLTGDVQLHPEASCLIMTTE----ILRSMLYSGSDVIRDLEWVIFDEVHYINDV 431
Query: 1461 ERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLN-IKQMGLFNFRPSVRP 1519
ERG V E ++ + H V I+ LS + NA + ADW+ +K+ ++ RP
Sbjct: 432 ERGVVWEEVLI---MLPDH----VSIILLSATVPNALEFADWIGRLKRRQIYVISTVTRP 484
Query: 1520 VPLEVHI--------QG-----------FPGQHYCPRMASMNKP---------AFQAIRS 1551
VPLE ++ QG F + Y + + + A Q
Sbjct: 485 VPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQ 544
Query: 1552 HSPAK------------------PVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDE 1593
PA+ PV++F SR + A L + T K +++
Sbjct: 545 GGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLF- 603
Query: 1594 REMENIIATVRDSNLKLT--------LAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIA 1645
++ +A +R S+ +L L G+G+HH+G+ ++ VE LF V+VL A
Sbjct: 604 --LQRCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFA 661
Query: 1646 TSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVIL 1704
T T A GVN PA V+ +DG T R D + +QM GRAGR D G ++L
Sbjct: 662 TETFAMGVNMPARTVVFDSMRKHDGSTFR--DLLPGEYVQMAGRAGRRGLDPTGTVILL 718
Score = 62.8 bits (151), Expect = 4e-09
Identities = 37/95 (38%), Positives = 53/95 (55%), Gaps = 2/95 (2%)
Query: 773 ELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYA 832
EL G +HH+G+L + +VE LFS G +KVL T T A GVN+PA V+ + +
Sbjct: 626 ELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHD 685
Query: 833 AKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIII 867
+F DL + +Q+ GRAGR D G I++
Sbjct: 686 G--STFRDLLPGEYVQMAGRAGRRGLDPTGTVILL 718
Score = 48.9 bits (115), Expect = 5e-05
Identities = 47/191 (24%), Positives = 90/191 (47%), Gaps = 29/191 (15%)
Query: 492 NENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFS 551
++++ + A T AGKT +A + + +K+ + +Y +P+KAL+ + F
Sbjct: 325 HDSVFVAAHTSAGKTVVAEYAI----------ALAQKHMTRTIYTSPIKALSNQKFRDFR 374
Query: 552 RRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILD 611
+G+ LTGD+QL + +++TT +++ + + + +I D
Sbjct: 375 NTFGDVGL----LTGDVQLHPEA---SCLIMTT----EILRSMLYSGSDVIRDLEWVIFD 423
Query: 612 EVHLLHE-DRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLF 670
EVH +++ +RG V E ++ V I+ LSAT+PN L+ A ++ ++
Sbjct: 424 EVHYINDVERGVVWEEVLIMLPDHVS-------IILLSATVPNALEFADWIGRLKRRQIY 476
Query: 671 FFDGRFRPVPL 681
RPVPL
Sbjct: 477 VISTVTRPVPL 487
>gi|239756904 PREDICTED: similar to SNRNP200 protein [Homo sapiens]
Length = 302
Score = 97.4 bits (241), Expect = 1e-19
Identities = 49/121 (40%), Positives = 76/121 (62%), Gaps = 1/121 (0%)
Query: 1852 AEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDT 1911
A Y ++P++H+E++ +LA+ +P + N F+ PH K +LLLQAHLSR L + +
Sbjct: 33 ATGYENIPIQHHEENFLRQLAQKVPDKLNNPKFNDPHIKTNLLLQAHLSRMQLSA-ELQS 91
Query: 1912 DTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHH 1971
DT+ +L +A+R+ QA +DV ++ GWL + L L QMV Q W KDS L LP+ + H
Sbjct: 92 DTEEILSKAVRLVQACVDVLSSNGWLSSALAAMELAQMVTQAMWSKDSYLKQLPHFISEH 151
Query: 1972 L 1972
+
Sbjct: 152 I 152
Score = 67.0 bits (162), Expect = 2e-10
Identities = 30/80 (37%), Positives = 50/80 (62%), Gaps = 2/80 (2%)
Query: 2103 VTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFM 2162
+ P FP+ ++EGW++++G+ LI++KR+ ++ L F P G + YTLYFM
Sbjct: 218 IAPLFPQKREEGWWVVIGDTKSNSLISIKRL-ILQQKAKVKLDFVAPAT-GAHNYTLYFM 275
Query: 2163 SDCYLGLDQQYDIYLNVTQA 2182
SD Y+G DQ+Y ++V +A
Sbjct: 276 SDAYMGCDQEYKFSMDVKEA 295
Score = 45.4 bits (106), Expect = 6e-04
Identities = 55/274 (20%), Positives = 117/274 (42%), Gaps = 34/274 (12%)
Query: 1018 AEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLIS 1077
A ++ I ++ E L L + + + K N+LLQ ++SR ++ S L S
Sbjct: 33 ATGYENIPIQHHEENFLRQLAQKVPDKLNNPKFNDPHIKTNLLLQAHLSRMQL-SAELQS 91
Query: 1078 DSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQF-SILPPH 1136
D+ + A R+V+A ++ W + + L++++ + +W S L+Q + H
Sbjct: 92 DTEEILSKAVRLVQACVDVLSSNGWLSSALAAMELAQMVTQAMWSKDSYLKQLPHFISEH 151
Query: 1137 ILTRLEEKKLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVL 1196
I ++ +V + +M +E IL + + V+ + SI+ V+
Sbjct: 152 IKRCTDKGVKSVFDIMEMEDEERNTILQLTDSQI--------TDEVVDKDSIRSGGPAVV 203
Query: 1197 RVTLSIYADFTWNDQVHGTVGEP---------WWIWVEDPTNDHIYHSEYFLALKKQVIS 1247
V L ++V G V P WW+ + D ++ + +++K+ ++
Sbjct: 204 LVQLE------REEEVTGPVIAPLFPQKREEGWWVVIGDTKSNSL------ISIKRLILQ 251
Query: 1248 KEAQL-LVFTIPIFEPLPSQYYIRAVSDRWLGAE 1280
++A++ L F P Y + +SD ++G +
Sbjct: 252 QKAKVKLDFVAPATG--AHNYTLYFMSDAYMGCD 283
>gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sapiens]
Length = 1712
Score = 60.1 bits (144), Expect = 2e-08
Identities = 32/97 (32%), Positives = 52/97 (53%), Gaps = 9/97 (9%)
Query: 767 RNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIK 826
+ ++++ L G HH+ M +++ LVE LF G+++V+ T TLA GVN+P +V+
Sbjct: 1249 KGEELKALAERGIGYHHSAMSFKEKQLVEILFRKGYLRVVTATGTLALGVNMPCKSVVFA 1308
Query: 827 GTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGE 863
+Y L L+ Q+ GRAGR D G+
Sbjct: 1309 QNSVY---------LDALNYRQMSGRAGRRGQDLMGD 1336
Score = 57.0 bits (136), Expect = 2e-07
Identities = 43/164 (26%), Positives = 80/164 (48%), Gaps = 16/164 (9%)
Query: 1344 NVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKK 1403
+ ++ APT SGKT A+ + +V + VY+AP KALV + + R + L
Sbjct: 780 SAVIVAPTSSGKTYASYYCMEKVLKESDDGVVVYVAPTKALVNQVAATVQNRFTKNLPSG 839
Query: 1404 VIELTGDVTPDMKSIA-KADLIVTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGEER 1462
+ L G T + + A +++T P ++ + + +N+V+++ +I DE+H LG E
Sbjct: 840 EV-LCGVFTREYRHDALNCQVLITVPACFEILLLAPHRQNWVKKIRYVIFDEVHCLGGEI 898
Query: 1463 GPVL---EVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWL 1503
G + +++ R F++ LS ++N L +WL
Sbjct: 899 GAEIWEHLLVMIRCPFLA-----------LSATISNPEHLTEWL 931
Score = 49.3 bits (116), Expect = 4e-05
Identities = 34/97 (35%), Positives = 47/97 (48%), Gaps = 11/97 (11%)
Query: 1604 RDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVII- 1662
+ LK GIG HH+ + ++++ VE LF ++V+ AT TLA GVN P V+
Sbjct: 1249 KGEELKALAERGIGYHHSAMSFKEKQLVEILFRKGYLRVVTATGTLALGVNMPCKSVVFA 1308
Query: 1663 KGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQG 1699
+ + Y D R QM GRAGR D G
Sbjct: 1309 QNSVYLDALNYR----------QMSGRAGRRGQDLMG 1335
Score = 45.4 bits (106), Expect = 6e-04
Identities = 49/168 (29%), Positives = 78/168 (46%), Gaps = 28/168 (16%)
Query: 492 NENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKAL----AAEMT 547
NE+ +I APT +GKT A + ++ + GV +VYVAP KAL AA +
Sbjct: 778 NESAVIVAPTSSGKT-YASYYCMEKVLKESDDGV-------VVYVAPTKALVNQVAATVQ 829
Query: 548 DYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRL 607
+ F++ L ++ T + + + L Q+L+T P ++++ + +I R
Sbjct: 830 NRFTKNLPSGEVLCGVFTREY---RHDALNCQVLITVPACFEILLLAPHRQNWVKKI-RY 885
Query: 608 LILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIR--ILGLSATLPN 653
+I DEVH L + G + E MIR L LSAT+ N
Sbjct: 886 VIFDEVHCLGGEIGAEI----------WEHLLVMIRCPFLALSATISN 923
>gi|6005872 SEC63-like protein [Homo sapiens]
Length = 760
Score = 54.7 bits (130), Expect = 1e-06
Identities = 38/123 (30%), Positives = 59/123 (47%), Gaps = 3/123 (2%)
Query: 2063 ADKRDDNKWIKLHADQEYVLQVSLQRVHFGF--HKGKPESCAVTPRFPKSKDEGWFLILG 2120
+D+ D K K + LQ S+QR K K + FP+ K E W+L +
Sbjct: 597 SDREQDEKQNKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIA 656
Query: 2121 EVDKRELIALK-RVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLDQQYDIYLNV 2179
+ ++ LI++ V +++ L F P PG Y YT++ SD Y+GLDQ + L V
Sbjct: 657 DRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEV 716
Query: 2180 TQA 2182
+A
Sbjct: 717 HEA 719
Score = 38.1 bits (87), Expect = 0.096
Identities = 54/242 (22%), Positives = 101/242 (41%), Gaps = 41/242 (16%)
Query: 1843 EELLSILSDAEEYT-----DLPVRHNEDHMNSELAK---CLPIESNPHSFDSPHT-KAHL 1893
+ L+ +L+ A E+ D R ++ + +L + + ++ N P++ KA +
Sbjct: 244 KRLIMVLAGASEFDPQYNKDATSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARV 303
Query: 1894 LLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDV-------AANQG-------WLVT 1939
LL +HL+R +P + D + +L + + Q M++V A N+ L +
Sbjct: 304 LLLSHLARMKIP-ETLEEDQQFMLKKCPALLQEMVNVICQLIVMARNREEREFRAPTLAS 362
Query: 1940 VLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPEL 1999
+ N L QM +QG S LL LP+IE +L K + I+++ +L
Sbjct: 363 LENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHK----------KYKIKTIQDL 412
Query: 2000 IHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVS 2059
+ H +E E K ++ L P + + I + D E N ++V
Sbjct: 413 VSLKESDRHTLLHFLEDE----KYEEVMAVLGSFPYVTMDIKSQVLDD---EDSNNITVG 465
Query: 2060 TL 2061
+L
Sbjct: 466 SL 467
>gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Homo
sapiens]
Length = 1706
Score = 54.3 bits (129), Expect = 1e-06
Identities = 31/94 (32%), Positives = 48/94 (51%), Gaps = 9/94 (9%)
Query: 769 KQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGT 828
K+++ L G HH+ M +++ VE LF G I+V+ T TLA G+++P +V+
Sbjct: 1235 KELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGIHMPCKSVVFAQD 1294
Query: 829 QIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFG 862
+Y L L+ Q+ GRAGR D G
Sbjct: 1295 SVY---------LDALNYRQMSGRAGRRGQDLLG 1319
Score = 53.9 bits (128), Expect = 2e-06
Identities = 46/171 (26%), Positives = 82/171 (47%), Gaps = 21/171 (12%)
Query: 1344 NVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKL--G 1401
+ ++ APT SGKT A+ + +V + VY+AP K+LV + + R + L G
Sbjct: 760 SAVIVAPTSSGKTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTLPAG 819
Query: 1402 KKVIELTGDVTPD-MKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGE 1460
+ L G T D ++ +++T PE ++ + + + +V+++ +I DE+H LG
Sbjct: 820 R---TLCGAFTRDYCHNVLNCQVLITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLGR 876
Query: 1461 ERGP---VLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWL-NIKQ 1507
E G L +++ R F+ LS + N L WL ++KQ
Sbjct: 877 EVGAKFWELLLVIIRCPFLV-----------LSATINNPNLLTKWLQSVKQ 916
Score = 53.9 bits (128), Expect = 2e-06
Identities = 41/131 (31%), Positives = 60/131 (45%), Gaps = 13/131 (9%)
Query: 1593 EREMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWG 1652
ER + + T LK GIG HH+ ++ ++++ VE LFV ++V+ AT TLA G
Sbjct: 1222 ERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALG 1281
Query: 1653 VNFPAHLVII-KGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKD 1711
++ P V+ + + Y D R QM GRAGR D G + DI
Sbjct: 1282 IHMPCKSVVFAQDSVYLDALNYR----------QMSGRAGRRGQDLLGN--VYFFDIPLP 1329
Query: 1712 FYKKFLYEPFP 1722
K+ L P
Sbjct: 1330 KIKRLLASSVP 1340
Score = 45.1 bits (105), Expect = 8e-04
Identities = 47/166 (28%), Positives = 76/166 (45%), Gaps = 24/166 (14%)
Query: 492 NENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKAL----AAEMT 547
NE+ +I APT +GKT A + ++ + GV +VYVAP K+L AA +
Sbjct: 758 NESAVIVAPTSSGKT-YASYYCMEKVLRESDVGV-------VVYVAPAKSLVGQVAATVE 809
Query: 548 DYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRL 607
+ F++ L + T D +L Q+L+T PE ++++ + +I R
Sbjct: 810 NRFTKTLPAGRTLCGAFTRDY---CHNVLNCQVLITVPECFEILLLAPHRQKWVERI-RY 865
Query: 608 LILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPN 653
+I DEVH L + G ++ +R L LSAT+ N
Sbjct: 866 VIFDEVHYLGREVGAKFWELLLVIIR--------CPFLVLSATINN 903
>gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo
sapiens]
Length = 491
Score = 49.3 bits (116), Expect = 4e-05
Identities = 71/337 (21%), Positives = 133/337 (39%), Gaps = 62/337 (18%)
Query: 495 MLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSRRL 554
+L APTG+GKT + +L +++Q +G F+ + ++P + LA+++ +
Sbjct: 97 LLASAPTGSGKTLAFSIPILMQLKQPANKG------FRALIISPTRELASQIHRELIKIS 150
Query: 555 EPLG----IIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLIL 610
E G +I K + + +LVTTP + + ++ + L+ V L++
Sbjct: 151 EGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDLAS-VEWLVV 209
Query: 611 DEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLF 670
DE L ED +A + T +R SAT DV + +N
Sbjct: 210 DESDKLFEDGKTGFRDQLASIF--LACTSHKVRRAMFSATFA--YDVEQWCKLN------ 259
Query: 671 FFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHARNATVR 730
L+N+ V V+ Q ++FV + +
Sbjct: 260 --------------------------LDNVISVSIGARNSAVETVEQELLFVGSETGKLL 293
Query: 731 TAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIH--HAGMLR 788
L+++ N + F + ++R++ + EL +G ++ HA +
Sbjct: 294 AMRELVKKGFNPPVLVFV------------QSIERAK-ELFHELIYEGINVDVIHAERTQ 340
Query: 789 QDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVII 825
Q R+ + F G I VL+CTA LA G++ ++I
Sbjct: 341 QQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVI 377
Score = 44.3 bits (103), Expect = 0.001
Identities = 90/387 (23%), Positives = 151/387 (39%), Gaps = 76/387 (19%)
Query: 1329 PVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSK---AVYIAPLKALV 1385
P+Q Q + H +L APTGSGKT+A + I K P +K A+ I+P + L
Sbjct: 82 PIQMQAIPVMLHGR-ELLASAPTGSGKTLAFSIPILMQL-KQPANKGFRALIISPTRELA 139
Query: 1386 RERMDDWKVRIEEKLGKKVIELTGDVTP----DMKSIAKADLIVTTPEKWDGVSRSWQNR 1441
++ ++I E G ++ + KS K D++VTTP + + +
Sbjct: 140 -SQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPG 198
Query: 1442 NYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLAD 1501
+ V L++DE L E+ ++ + F++ + K R + +T A D+
Sbjct: 199 IDLASVEWLVVDESDKLFEDGKTGFRDQLA-SIFLACTSHKVRRAMFSATF---AYDVEQ 254
Query: 1502 WLNIKQMGLFNFRPSVRPVPLEVHIQG--FPGQHYCPRMA--SMNKPAFQAIRSHSPAKP 1557
W + + + R +E Q F G +A + K F P
Sbjct: 255 WCKLNLDNVISVSIGARNSAVETVEQELLFVGSETGKLLAMRELVKKGFN--------PP 306
Query: 1558 VLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIG 1617
VL+FV S + + ELI + +N+D
Sbjct: 307 VLVFVQSIERAKELFHELI---------YEGINVD------------------------- 332
Query: 1618 MHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVD 1677
+ HA ++ R F K+ VLI T+ LA G++F ++I D
Sbjct: 333 VIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVIN------------YD 380
Query: 1678 FPITDV--LQMMGRAGRPQFDDQGKAV 1702
FP + V + +GR GR ++GKA+
Sbjct: 381 FPTSSVEYIHRIGRTGRA--GNKGKAI 405
>gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo
sapiens]
Length = 599
Score = 49.3 bits (116), Expect = 4e-05
Identities = 71/337 (21%), Positives = 133/337 (39%), Gaps = 62/337 (18%)
Query: 495 MLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSRRL 554
+L APTG+GKT + +L +++Q +G F+ + ++P + LA+++ +
Sbjct: 205 LLASAPTGSGKTLAFSIPILMQLKQPANKG------FRALIISPTRELASQIHRELIKIS 258
Query: 555 EPLG----IIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLIL 610
E G +I K + + +LVTTP + + ++ + L+ V L++
Sbjct: 259 EGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDLAS-VEWLVV 317
Query: 611 DEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLF 670
DE L ED +A + T +R SAT DV + +N
Sbjct: 318 DESDKLFEDGKTGFRDQLASIF--LACTSHKVRRAMFSATFA--YDVEQWCKLN------ 367
Query: 671 FFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHARNATVR 730
L+N+ V V+ Q ++FV + +
Sbjct: 368 --------------------------LDNVISVSIGARNSAVETVEQELLFVGSETGKLL 401
Query: 731 TAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIH--HAGMLR 788
L+++ N + F + ++R++ + EL +G ++ HA +
Sbjct: 402 AMRELVKKGFNPPVLVFV------------QSIERAK-ELFHELIYEGINVDVIHAERTQ 448
Query: 789 QDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVII 825
Q R+ + F G I VL+CTA LA G++ ++I
Sbjct: 449 QQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVI 485
Score = 44.3 bits (103), Expect = 0.001
Identities = 90/387 (23%), Positives = 151/387 (39%), Gaps = 76/387 (19%)
Query: 1329 PVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSK---AVYIAPLKALV 1385
P+Q Q + H +L APTGSGKT+A + I K P +K A+ I+P + L
Sbjct: 190 PIQMQAIPVMLHGR-ELLASAPTGSGKTLAFSIPILMQL-KQPANKGFRALIISPTRELA 247
Query: 1386 RERMDDWKVRIEEKLGKKVIELTGDVTP----DMKSIAKADLIVTTPEKWDGVSRSWQNR 1441
++ ++I E G ++ + KS K D++VTTP + + +
Sbjct: 248 -SQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPG 306
Query: 1442 NYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLAD 1501
+ V L++DE L E+ ++ + F++ + K R + +T A D+
Sbjct: 307 IDLASVEWLVVDESDKLFEDGKTGFRDQLA-SIFLACTSHKVRRAMFSATF---AYDVEQ 362
Query: 1502 WLNIKQMGLFNFRPSVRPVPLEVHIQG--FPGQHYCPRMA--SMNKPAFQAIRSHSPAKP 1557
W + + + R +E Q F G +A + K F P
Sbjct: 363 WCKLNLDNVISVSIGARNSAVETVEQELLFVGSETGKLLAMRELVKKGFN--------PP 414
Query: 1558 VLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIG 1617
VL+FV S + + ELI + +N+D
Sbjct: 415 VLVFVQSIERAKELFHELI---------YEGINVD------------------------- 440
Query: 1618 MHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVD 1677
+ HA ++ R F K+ VLI T+ LA G++F ++I D
Sbjct: 441 VIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVIN------------YD 488
Query: 1678 FPITDV--LQMMGRAGRPQFDDQGKAV 1702
FP + V + +GR GR ++GKA+
Sbjct: 489 FPTSSVEYIHRIGRTGRA--GNKGKAI 513
>gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I
[Homo sapiens]
Length = 925
Score = 46.2 bits (108), Expect = 4e-04
Identities = 34/125 (27%), Positives = 60/125 (48%), Gaps = 10/125 (8%)
Query: 493 ENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSR 552
+N +ICAPTG GKT +++L H +++ F QG + K+V+ A + + FS+
Sbjct: 258 KNTIICAPTGCGKTFVSLLICEHHLKK-FPQG----QKGKVVFFANQIPVYEQQKSVFSK 312
Query: 553 RLEPLGIIVKELTGDMQLS---KSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLI 609
E G V ++G + + + +++ TP+ +V G + I L+I
Sbjct: 313 YFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQ--ILVNNLKKGTIPSLSIFTLMI 370
Query: 610 LDEVH 614
DE H
Sbjct: 371 FDECH 375
>gi|74959747 Fanconi anemia, complementation group M [Homo sapiens]
Length = 2048
Score = 45.4 bits (106), Expect = 6e-04
Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 19/159 (11%)
Query: 494 NMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSRR 553
N L+C PTG GKT IA + V++ + F G K+V++AP K L + + +
Sbjct: 106 NTLVCLPTGLGKTFIAAV-VMYNFYRWFPSG-------KVVFMAPTKPLVTQQIEACYQV 157
Query: 554 LEPLGIIVKELTGDMQLS-KSEI-LRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILD 611
+ + E+TG Q S + EI ++L TP+ +V S G ++I + L++D
Sbjct: 158 MGIPQSHMAEMTGSTQASTRKEIWCSKRVLFLTPQV--MVNDLSRGACPAAEI-KCLVID 214
Query: 612 EVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSAT 650
E H + + +R++ + RIL LSAT
Sbjct: 215 EAH------KALGNYAYCQVVRELVKYTNHFRILALSAT 247
Score = 44.7 bits (104), Expect = 0.001
Identities = 18/48 (37%), Positives = 31/48 (64%)
Query: 1343 CNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMD 1390
CN L+ PTG GKT A + ++ + +P+ K V++AP K LV ++++
Sbjct: 105 CNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIE 152
>gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo
sapiens]
Length = 483
Score = 42.4 bits (98), Expect = 0.005
Identities = 95/414 (22%), Positives = 168/414 (40%), Gaps = 87/414 (21%)
Query: 491 TNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYF 550
+ ++L A G GK+ ++ +L + +KK+ + + + P + LA +++
Sbjct: 132 SGRDILARAKNGTGKSGAYLIPLLERLD-------LKKDNIQAMVIVPTRELALQVSQIC 184
Query: 551 SRRLEPLG-IIVKELTGDMQLSKSEILR----TQMLVTTPEKWDVVTRKSVGDVALSQIV 605
+ + +G V TG L + +I+R +++ TP + + +K V V V
Sbjct: 185 IQVSKHMGGAKVMATTGGTNL-RDDIMRLDDTVHVVIATPGRILDLIKKGVAKV---DHV 240
Query: 606 RLLILDEVH-LLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVN 664
++++LDE LL +D ++E I+ + + IL SAT P L V F++ +
Sbjct: 241 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQ-------ILLYSATFP--LSVQKFMNSH 291
Query: 665 PYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHA 724
K ++N M+E+ + V Q +V
Sbjct: 292 --------------------------LQKPYEINLMEELTLKGVT-------QYYAYVTE 318
Query: 725 RNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHA 784
R V +L R + I F +Q + + K++ +L F IH A
Sbjct: 319 RQK-VHCLNTLFSRLQINQSIIFCNSSQRVELLA----------KKISQLGYSCFYIH-A 366
Query: 785 GMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGIL 844
M ++ RN V + F NG + LVCT G+++ A V+I F L
Sbjct: 367 KMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVI---------NFDFPKLAET 417
Query: 845 DVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLT----LLTQRNPIESQFLESL 894
+ +I GR+GR F G I + T+D + + L T+ PI S +SL
Sbjct: 418 YLHRI-GRSGR--FGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSL 468
>gi|116812616 RecQ protein-like 4 [Homo sapiens]
Length = 1208
Score = 40.4 bits (93), Expect = 0.019
Identities = 108/482 (22%), Positives = 173/482 (35%), Gaps = 113/482 (23%)
Query: 1291 ILPERHP-PHTELLDLQPLPITALG---------CKAYEALYNFSH--FNPVQTQIFHTL 1338
++P P P LD LP+ +LG + ++AL H F P Q + +
Sbjct: 433 LVPSPQPVPEVPSLDPTVLPLYSLGPSGQLAETPAEVFQALEQLGHQAFRPGQERAVMRI 492
Query: 1339 YHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEE 1398
+ + LL PTG+GK++ +L + P V ++PL +L MDD +
Sbjct: 493 L-SGISTLLVLPTGAGKSLCYQLPALLYSRRSPCLTLV-VSPLLSL----MDDQVSGLPP 546
Query: 1399 KLGKKVIELTGDVTPDMKSI------AKADLIVTTPEKWDGVSRSWQNRNYVQQVTILII 1452
L I +G +S+ A+ +++ TPE G + V I
Sbjct: 547 CLKAACIH-SGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAG-GLPPAAQLPPVAFACI 604
Query: 1453 DEIHLLGEE----RGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQM 1508
DE H L + R L V + H +GL TA A R +D + Q
Sbjct: 605 DEAHCLSQWSHNFRPCYLRVCKVLRERMGVHC-----FLGL-TATATRRTASD---VAQH 655
Query: 1509 GLFNFRPSVR---PVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAK------PVL 1559
P + PVP +H+ SM++ QA+ + K ++
Sbjct: 656 LAVAEEPDLHGPAPVPTNLHLS-----------VSMDRDTDQALLTLLQGKRFQNLDSII 704
Query: 1560 IFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMH 1619
I+ + R T A L L P + E +
Sbjct: 705 IYCNRREDTERIAALLRTCLHAAWVPGSGGRAPKTTAE--------------------AY 744
Query: 1620 HAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFP-----AHLVIIKGTEYYDGKTRR 1674
HAG+ R+R+ V+ F+ +++V++AT G++ P HL + E Y
Sbjct: 745 HAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESY------ 798
Query: 1675 YVDFPITDVLQMMGRAGR------------PQFDDQGKAVILVHDIKKDF--YKKFLYEP 1720
+Q +GRAGR PQ +D + VH DF K+ +
Sbjct: 799 ---------VQAVGRAGRDGQPAHCHLFLQPQGEDLRELRRHVHADSTDFLAVKRLVQRV 849
Query: 1721 FP 1722
FP
Sbjct: 850 FP 851
>gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3
[Homo sapiens]
Length = 724
Score = 40.4 bits (93), Expect = 0.019
Identities = 62/233 (26%), Positives = 104/233 (44%), Gaps = 34/233 (14%)
Query: 448 PMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTN 507
P L+FEE + Q L+ +A G +L +Q +++ CA TG+GKT
Sbjct: 285 PAILTFEEANL-CQTLNN--NIAKAGYTKLTPVQKYSIPIIL-AGRDLMACAQTGSGKTA 340
Query: 508 IAMLTVLHEIRQHFQQGVIKKNEFK------IVYVAPMKALAAEMTDYFSRRLEPLGIIV 561
+L +L H I + FK + VAP + L ++ Y R G V
Sbjct: 341 AFLLPIL----AHMMHDGITASRFKELQEPECIIVAPTRELVNQI--YLEARKFSFGTCV 394
Query: 562 KELT--GDMQLSKS--EILR-TQMLVTTPEK-WDVVTRKSVGDVALSQIVRLLILDEV-H 614
+ + G QL S +I++ +L TP + D++ ++ +G L QI + L+LDE
Sbjct: 395 RAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIG---LKQI-KYLVLDEADR 450
Query: 615 LLHEDRGPVLESIVA-RTLRQVESTQSMIRILGLSATLPNYLD--VATFLHVN 664
+L GP ++ +++ + E Q+++ SAT P + A FL N
Sbjct: 451 MLDMGFGPEMKKLISCPGMPSKEQRQTLM----FSATFPEEIQRLAAEFLKSN 499
>gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1
[Homo sapiens]
Length = 724
Score = 40.4 bits (93), Expect = 0.019
Identities = 62/233 (26%), Positives = 104/233 (44%), Gaps = 34/233 (14%)
Query: 448 PMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTN 507
P L+FEE + Q L+ +A G +L +Q +++ CA TG+GKT
Sbjct: 285 PAILTFEEANL-CQTLNN--NIAKAGYTKLTPVQKYSIPIIL-AGRDLMACAQTGSGKTA 340
Query: 508 IAMLTVLHEIRQHFQQGVIKKNEFK------IVYVAPMKALAAEMTDYFSRRLEPLGIIV 561
+L +L H I + FK + VAP + L ++ Y R G V
Sbjct: 341 AFLLPIL----AHMMHDGITASRFKELQEPECIIVAPTRELVNQI--YLEARKFSFGTCV 394
Query: 562 KELT--GDMQLSKS--EILR-TQMLVTTPEK-WDVVTRKSVGDVALSQIVRLLILDEV-H 614
+ + G QL S +I++ +L TP + D++ ++ +G L QI + L+LDE
Sbjct: 395 RAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIG---LKQI-KYLVLDEADR 450
Query: 615 LLHEDRGPVLESIVA-RTLRQVESTQSMIRILGLSATLPNYLD--VATFLHVN 664
+L GP ++ +++ + E Q+++ SAT P + A FL N
Sbjct: 451 MLDMGFGPEMKKLISCPGMPSKEQRQTLM----FSATFPEEIQRLAAEFLKSN 499
>gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2
[Homo sapiens]
Length = 690
Score = 40.4 bits (93), Expect = 0.019
Identities = 62/233 (26%), Positives = 104/233 (44%), Gaps = 34/233 (14%)
Query: 448 PMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTN 507
P L+FEE + Q L+ +A G +L +Q +++ CA TG+GKT
Sbjct: 251 PAILTFEEANL-CQTLNN--NIAKAGYTKLTPVQKYSIPIIL-AGRDLMACAQTGSGKTA 306
Query: 508 IAMLTVLHEIRQHFQQGVIKKNEFK------IVYVAPMKALAAEMTDYFSRRLEPLGIIV 561
+L +L H I + FK + VAP + L ++ Y R G V
Sbjct: 307 AFLLPIL----AHMMHDGITASRFKELQEPECIIVAPTRELVNQI--YLEARKFSFGTCV 360
Query: 562 KELT--GDMQLSKS--EILR-TQMLVTTPEK-WDVVTRKSVGDVALSQIVRLLILDEV-H 614
+ + G QL S +I++ +L TP + D++ ++ +G L QI + L+LDE
Sbjct: 361 RAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIG---LKQI-KYLVLDEADR 416
Query: 615 LLHEDRGPVLESIVA-RTLRQVESTQSMIRILGLSATLPNYLD--VATFLHVN 664
+L GP ++ +++ + E Q+++ SAT P + A FL N
Sbjct: 417 MLDMGFGPEMKKLISCPGMPSKEQRQTLM----FSATFPEEIQRLAAEFLKSN 465
>gi|110735439 Werner syndrome protein [Homo sapiens]
Length = 1432
Score = 39.7 bits (91), Expect = 0.033
Identities = 70/339 (20%), Positives = 130/339 (38%), Gaps = 59/339 (17%)
Query: 1322 YNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPL 1381
+ S F PVQ ++ H++ + + TG GK++ F+ Y + I+PL
Sbjct: 544 FGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLC-----FQYPPVYVGKIGLVISPL 598
Query: 1382 KALVRERMDDWKVRIEEK--LGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQ 1439
+L+ +++ K+ LG E +V D+K + K ++ TPE G Q
Sbjct: 599 ISLMEDQVLQLKMSNIPACFLGSAQSE---NVLTDIK-LGKYRIVYVTPEYCSGNMGLLQ 654
Query: 1440 NRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDL 1499
+T++ +DE H + E + + ++ P+ + + + + D+
Sbjct: 655 QLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDI 714
Query: 1500 ADWLNIK--QMGLFNF-RPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAK 1556
LN++ Q+ F RP++ LEV + + +P SH +
Sbjct: 715 VRCLNLRNPQITCTGFDRPNLY---LEV-------RRKTGNILQDLQPFLVKTSSHWEFE 764
Query: 1557 -PVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFG 1615
P +I+ SR+ T + + +R NL
Sbjct: 765 GPTIIYCPSRKMT----------------------------QQVTGELRKLNL------S 790
Query: 1616 IGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVN 1654
G +HAG+ RK + FV ++Q +IAT G+N
Sbjct: 791 CGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGIN 829
>gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent
helicase, partial [Homo sapiens]
Length = 1140
Score = 39.7 bits (91), Expect = 0.033
Identities = 70/339 (20%), Positives = 130/339 (38%), Gaps = 59/339 (17%)
Query: 1322 YNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPL 1381
+ S F PVQ ++ H++ + + TG GK++ F+ Y + I+PL
Sbjct: 252 FGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLC-----FQYPPVYVGKIGLVISPL 306
Query: 1382 KALVRERMDDWKVRIEEK--LGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQ 1439
+L+ +++ K+ LG E +V D+K + K ++ TPE G Q
Sbjct: 307 ISLMEDQVLQLKMSNIPACFLGSAQSE---NVLTDIK-LGKYRIVYVTPEYCSGNMGLLQ 362
Query: 1440 NRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDL 1499
+T++ +DE H + E + + ++ P+ + + + + D+
Sbjct: 363 QLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDI 422
Query: 1500 ADWLNIK--QMGLFNF-RPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAK 1556
LN++ Q+ F RP++ LEV + + +P SH +
Sbjct: 423 VRCLNLRNPQITCTGFDRPNLY---LEV-------RRKTGNILQDLQPFLVKTSSHWEFE 472
Query: 1557 -PVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFG 1615
P +I+ SR+ T + + +R NL
Sbjct: 473 GPTIIYCPSRKMT----------------------------QQVTGELRKLNL------S 498
Query: 1616 IGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVN 1654
G +HAG+ RK + FV ++Q +IAT G+N
Sbjct: 499 CGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGIN 537
>gi|148612816 RecQ protein-like 5 isoform 1 [Homo sapiens]
Length = 991
Score = 38.5 bits (88), Expect = 0.074
Identities = 80/396 (20%), Positives = 147/396 (37%), Gaps = 111/396 (28%)
Query: 492 NENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDY-- 549
N+++ +C PTGAGK+ L L +G+ + V+P+ AL + D+
Sbjct: 45 NKDVFVCMPTGAGKSLCYQLPAL------LAKGI-------TIVVSPLIALIQDQVDHLL 91
Query: 550 -FSRRLEPLGIIV-----KELTGDMQLSKSEILRTQMLVTTPEKWDVVT-RKSVGDVALS 602
R+ L + KEL D++ K + T++L TPE + + ++ +
Sbjct: 92 TLKVRVSSLNSKLSAQERKELLADLEREKPQ---TKILYITPEMAASSSFQPTLNSLVSR 148
Query: 603 QIVRLLILDEVHLL----HEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYL--D 656
++ L++DE H + H+ R L L + S + L+AT + D
Sbjct: 149 HLLSYLVVDEAHCVSQWGHDFRPDYLR------LGALRSRLGHAPCVALTATATPQVQED 202
Query: 657 VATFLHVNPYIGLF---------FFDGRFRPV---PLGQTFLGIKCANKMQQLNNMDEVC 704
V LH+ + +F F+D +F+ + P G N+ + C
Sbjct: 203 VFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG----------------NLKDFC 246
Query: 705 YENVLKQVKAGHQ--VMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQ 762
+ + ++ G +V+ R A + A+ L R N
Sbjct: 247 LKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNA-------------------- 286
Query: 763 VQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHA 822
+HAG+ +R LV+N + + V+V T + GV+ A+
Sbjct: 287 -----------------KAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVD-KANV 328
Query: 823 VIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQF 858
+ I + G + + G GR G+P +
Sbjct: 329 RFVAHWNIAKSMAGYYQESGRA------GRDGKPSW 358
>gi|51242943 RecQ protein-like 5 isoform 3 [Homo sapiens]
Length = 410
Score = 38.5 bits (88), Expect = 0.074
Identities = 80/396 (20%), Positives = 147/396 (37%), Gaps = 111/396 (28%)
Query: 492 NENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDY-- 549
N+++ +C PTGAGK+ L L +G+ + V+P+ AL + D+
Sbjct: 45 NKDVFVCMPTGAGKSLCYQLPAL------LAKGI-------TIVVSPLIALIQDQVDHLL 91
Query: 550 -FSRRLEPLGIIV-----KELTGDMQLSKSEILRTQMLVTTPEKWDVVT-RKSVGDVALS 602
R+ L + KEL D++ K + T++L TPE + + ++ +
Sbjct: 92 TLKVRVSSLNSKLSAQERKELLADLEREKPQ---TKILYITPEMAASSSFQPTLNSLVSR 148
Query: 603 QIVRLLILDEVHLL----HEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYL--D 656
++ L++DE H + H+ R L L + S + L+AT + D
Sbjct: 149 HLLSYLVVDEAHCVSQWGHDFRPDYLR------LGALRSRLGHAPCVALTATATPQVQED 202
Query: 657 VATFLHVNPYIGLF---------FFDGRFRPV---PLGQTFLGIKCANKMQQLNNMDEVC 704
V LH+ + +F F+D +F+ + P G N+ + C
Sbjct: 203 VFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG----------------NLKDFC 246
Query: 705 YENVLKQVKAGHQ--VMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQ 762
+ + ++ G +V+ R A + A+ L R N
Sbjct: 247 LKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNA-------------------- 286
Query: 763 VQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHA 822
+HAG+ +R LV+N + + V+V T + GV+ A+
Sbjct: 287 -----------------KAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVD-KANV 328
Query: 823 VIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQF 858
+ I + G + + G GR G+P +
Sbjct: 329 RFVAHWNIAKSMAGYYQESGRA------GRDGKPSW 358
>gi|51242947 RecQ protein-like 5 isoform 2 [Homo sapiens]
Length = 435
Score = 38.5 bits (88), Expect = 0.074
Identities = 80/396 (20%), Positives = 147/396 (37%), Gaps = 111/396 (28%)
Query: 492 NENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDY-- 549
N+++ +C PTGAGK+ L L +G+ + V+P+ AL + D+
Sbjct: 45 NKDVFVCMPTGAGKSLCYQLPAL------LAKGI-------TIVVSPLIALIQDQVDHLL 91
Query: 550 -FSRRLEPLGIIV-----KELTGDMQLSKSEILRTQMLVTTPEKWDVVT-RKSVGDVALS 602
R+ L + KEL D++ K + T++L TPE + + ++ +
Sbjct: 92 TLKVRVSSLNSKLSAQERKELLADLEREKPQ---TKILYITPEMAASSSFQPTLNSLVSR 148
Query: 603 QIVRLLILDEVHLL----HEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYL--D 656
++ L++DE H + H+ R L L + S + L+AT + D
Sbjct: 149 HLLSYLVVDEAHCVSQWGHDFRPDYLR------LGALRSRLGHAPCVALTATATPQVQED 202
Query: 657 VATFLHVNPYIGLF---------FFDGRFRPV---PLGQTFLGIKCANKMQQLNNMDEVC 704
V LH+ + +F F+D +F+ + P G N+ + C
Sbjct: 203 VFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG----------------NLKDFC 246
Query: 705 YENVLKQVKAGHQ--VMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQ 762
+ + ++ G +V+ R A + A+ L R N
Sbjct: 247 LKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNA-------------------- 286
Query: 763 VQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHA 822
+HAG+ +R LV+N + + V+V T + GV+ A+
Sbjct: 287 -----------------KAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVD-KANV 328
Query: 823 VIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQF 858
+ I + G + + G GR G+P +
Sbjct: 329 RFVAHWNIAKSMAGYYQESGRA------GRDGKPSW 358
>gi|149408122 RNA helicase LGP2 [Homo sapiens]
Length = 678
Score = 38.1 bits (87), Expect = 0.096
Identities = 36/155 (23%), Positives = 75/155 (48%), Gaps = 10/155 (6%)
Query: 1344 NVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKK 1403
N+++ PTG+GKT AA R +K V + LV + ++++ ++ +
Sbjct: 19 NIIIWLPTGAGKTRAAAYVAKRHLETVDGAKVVVLVNRVHLVTQHGEEFRRMLDGRW--T 76
Query: 1404 VIELTGDVTP--DMKSIAKA-DLIVTTPEKWDGVSRSWQNRNYVQQV--TILIIDEIHLL 1458
V L+GD+ P +A+ DL++ T E S + +V+ +++++DE H
Sbjct: 77 VTTLSGDMGPRAGFGHLARCHDLLICTAELLQMALTSPEEEEHVELTVFSLIVVDECH-- 134
Query: 1459 GEERGPVLEVIVSRTNFISSHTEKPV-RIVGLSTA 1492
+ V VI+S+ + +P+ +++GL+ +
Sbjct: 135 HTHKDTVYNVIMSQYLELKLQRAQPLPQVLGLTAS 169
Score = 37.0 bits (84), Expect = 0.21
Identities = 44/174 (25%), Positives = 81/174 (46%), Gaps = 38/174 (21%)
Query: 493 ENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSR 552
+N++I PTGAGKT A + ++H + + K+V + L + + F R
Sbjct: 18 KNIIIWLPTGAGKTRAA----AYVAKRHLE----TVDGAKVVVLVNRVHLVTQHGEEFRR 69
Query: 553 RLEPLGIIVKELTGDM---------------QLSKSEILRTQMLVTTPEKWDVVTRKSVG 597
L+ V L+GDM + +E+L QM +T+PE+ + V
Sbjct: 70 MLDGRW-TVTTLSGDMGPRAGFGHLARCHDLLICTAELL--QMALTSPEEEEHVE----- 121
Query: 598 DVALSQIVRLLILDEVHLLHEDRGPVLESIVARTLR-QVESTQSMIRILGLSAT 650
+ L+++DE H H+D V I+++ L +++ Q + ++LGL+A+
Sbjct: 122 ----LTVFSLIVVDECHHTHKD--TVYNVIMSQYLELKLQRAQPLPQVLGLTAS 169
>gi|29294649 dicer1 [Homo sapiens]
Length = 1922
Score = 37.0 bits (84), Expect = 0.21
Identities = 39/165 (23%), Positives = 75/165 (45%), Gaps = 13/165 (7%)
Query: 492 NENMLICAPTGAGKTNIAML---TVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTD 548
+ N ++C TG+GKT IA+L + ++IR F + K+ F + + + +
Sbjct: 57 DHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNG-KRTVFLVNSANQVAQQVSAVRT 115
Query: 549 YFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLL 608
+ ++ + + + E + Q+L+ T + + G ++LS I LL
Sbjct: 116 HSDLKVGEYSNLEVNASWTKERWNQEFTKHQVLIMT--CYVALNVLKNGYLSLSDI-NLL 172
Query: 609 ILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPN 653
+ DE HL +L+ ++ E+ S RILGL+A++ N
Sbjct: 173 VFDECHL------AILDHPYREIMKLCENCPSCPRILGLTASILN 211
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,744,067
Number of Sequences: 37866
Number of extensions: 3493497
Number of successful extensions: 9389
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 9160
Number of HSP's gapped (non-prelim): 148
length of query: 2202
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2084
effective length of database: 13,779,330
effective search space: 28716123720
effective search space used: 28716123720
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.