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Search of human proteins with 7669550
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7669550 vinculin isoform meta-VCL [Homo sapiens]
(1134 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7669550 vinculin isoform meta-VCL [Homo sapiens] 2197 0.0
gi|4507877 vinculin isoform VCL [Homo sapiens] 1947 0.0
gi|55770846 catenin, alpha 2 [Homo sapiens] 135 2e-31
gi|55770844 catenin, alpha 1 [Homo sapiens] 114 7e-25
gi|188497718 catenin, alpha 3 [Homo sapiens] 107 5e-23
gi|188497716 catenin, alpha 3 [Homo sapiens] 107 5e-23
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 54 6e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 54 6e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 54 6e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 54 6e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 54 6e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 54 6e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 54 6e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 54 6e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 54 6e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 54 6e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 54 6e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 54 6e-07
gi|112420968 coiled-coil domain containing 158 [Homo sapiens] 52 4e-06
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 50 9e-06
gi|156938343 talin 2 [Homo sapiens] 50 2e-05
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 48 5e-05
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 48 5e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 48 6e-05
gi|33356148 formin-like 1 [Homo sapiens] 48 6e-05
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 48 6e-05
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 47 8e-05
gi|33188443 microfilament and actin filament cross-linker protei... 47 1e-04
gi|33188445 microfilament and actin filament cross-linker protei... 47 1e-04
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 46 2e-04
>gi|7669550 vinculin isoform meta-VCL [Homo sapiens]
Length = 1134
Score = 2197 bits (5693), Expect = 0.0
Identities = 1134/1134 (100%), Positives = 1134/1134 (100%)
Query: 1 MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE 60
MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE
Sbjct: 1 MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE 60
Query: 61 TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS 120
TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS
Sbjct: 61 TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS 120
Query: 121 DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ 180
DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ
Sbjct: 121 DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ 180
Query: 181 ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE 240
ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE
Sbjct: 181 ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE 240
Query: 241 INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR 300
INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR
Sbjct: 241 INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR 300
Query: 301 QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL 360
QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL
Sbjct: 301 QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL 360
Query: 361 DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE 420
DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE
Sbjct: 361 DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE 420
Query: 421 LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA 480
LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA
Sbjct: 421 LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA 480
Query: 481 VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD 540
VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD
Sbjct: 481 VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD 540
Query: 541 LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS 600
LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS
Sbjct: 541 LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS 600
Query: 601 DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG 660
DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG
Sbjct: 601 DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG 660
Query: 661 IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK 720
IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK
Sbjct: 661 IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK 720
Query: 721 SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR 780
SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR
Sbjct: 721 SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR 780
Query: 781 EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP 840
EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP
Sbjct: 781 EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP 840
Query: 841 DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM 900
DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM
Sbjct: 841 DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM 900
Query: 901 AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ 960
AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ
Sbjct: 901 AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ 960
Query: 961 PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK 1020
PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK
Sbjct: 961 PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK 1020
Query: 1021 DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS 1080
DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS
Sbjct: 1021 DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS 1080
Query: 1081 DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ 1134
DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ
Sbjct: 1081 DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ 1134
>gi|4507877 vinculin isoform VCL [Homo sapiens]
Length = 1066
Score = 1947 bits (5043), Expect = 0.0
Identities = 1032/1134 (91%), Positives = 1039/1134 (91%), Gaps = 68/1134 (5%)
Query: 1 MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE 60
MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE
Sbjct: 1 MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE 60
Query: 61 TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS 120
TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS
Sbjct: 61 TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS 120
Query: 121 DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ 180
DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ
Sbjct: 121 DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ 180
Query: 181 ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE 240
ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE
Sbjct: 181 ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE 240
Query: 241 INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR 300
INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR
Sbjct: 241 INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR 300
Query: 301 QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL 360
QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL
Sbjct: 301 QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL 360
Query: 361 DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE 420
DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE
Sbjct: 361 DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE 420
Query: 421 LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA 480
LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA
Sbjct: 421 LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA 480
Query: 481 VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD 540
VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD
Sbjct: 481 VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD 540
Query: 541 LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS 600
LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS
Sbjct: 541 LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS 600
Query: 601 DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG 660
DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG
Sbjct: 601 DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG 660
Query: 661 IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK 720
IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK
Sbjct: 661 IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK 720
Query: 721 SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR 780
SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR
Sbjct: 721 SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR 780
Query: 781 EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP 840
EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP
Sbjct: 781 EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP 840
Query: 841 DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM 900
DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM
Sbjct: 841 DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM 900
Query: 901 AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ 960
AARQLHDEARKWSSK G ++A A
Sbjct: 901 AARQLHDEARKWSSK--------GNDIIAAAK---------------------------- 924
Query: 961 PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK 1020
+L A S R S +I AK +A E++RL
Sbjct: 925 --RMALLMAEMS--RLVRGGSGTKRALIQCAKDIAKASDEVTRL---------------- 964
Query: 1021 DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS 1080
AKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS
Sbjct: 965 ------------AKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS 1012
Query: 1081 DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ 1134
DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ
Sbjct: 1013 DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ 1066
>gi|55770846 catenin, alpha 2 [Homo sapiens]
Length = 905
Score = 135 bits (341), Expect = 2e-31
Identities = 176/763 (23%), Positives = 299/763 (39%), Gaps = 114/763 (14%)
Query: 404 GEEQIRGALAEARKIAELCDDPKERDDILRSLGEISA-----LTSKLADLRRQGKGDSPE 458
G+E ++ AR+ EL DP RD++ + G + T+ A LR +
Sbjct: 180 GKEMVKLNYVAARRQQEL-KDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAATRA 238
Query: 459 ARALA-KQVATALQNLQTKTNRAVANSRPAKAAVHLE-GKIEQAQRWIDNPTV-DDRGVG 515
R KQV A+ + +N A A S +A H G++ A DN + D
Sbjct: 239 NRDYVFKQVQEAIAGI---SNAAQATSPTDEAKGHTGIGELAAALNEFDNKIILDPMTFS 295
Query: 516 QAAIRGLVAEGHRLANVMMGPY------------RQDLLAKCDRVDQLTAQLADLAARGE 563
+A R + E RL +++ G R+ ++A+C+ V Q L
Sbjct: 296 EARFRPSLEE--RLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNT 353
Query: 564 GESPQARAL---ASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAP 620
G + L ++ +DL+ ++++A+ +SD F +T P+ +L AA +
Sbjct: 354 GRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLETNVPLLVLIEAAKSG---- 409
Query: 621 NREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAAR 680
N +EV E A F H+ KL A A ++ N+ V+ ++ + L PQV++AA
Sbjct: 410 NEKEV-KEYAQVFREHANKLVEVANLACSISN-NEEGVKLVRMAATQIDSLCPQVINAAL 467
Query: 681 ILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVA 740
L P ++ A ++ + K+QW V +T VD+ L SE I +D++KC +A
Sbjct: 468 TLAARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIA 527
Query: 741 MANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMD 800
+ L A +I RA R++ + E+EN E + E V A+ LS+T+ P +
Sbjct: 528 LQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAE 587
Query: 801 -----AKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLT 855
+A++ N+ P + F+D+ + V +R+A + +R
Sbjct: 588 QVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKA--------------VLMIRTP 633
Query: 856 DELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSSK 915
+EL E R E D+ Q A ++ Q ++ ++ + +
Sbjct: 634 EELEDDSDFEQEDYDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQE 693
Query: 916 PGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHR 975
AEV DD +++++ Q + +
Sbjct: 694 KSKLDAEVA--------------------KWDDSGNDIIVL-----AKQMCMIMMEMTDF 728
Query: 976 EATKWSSKG-NDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAK 1034
K K +D+I AAK++A + M +L R
Sbjct: 729 TRGKGPLKNTSDVINAAKKIAEAGSRMDKLARA--------------------------- 761
Query: 1035 EVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHN 1094
VA QC D + +LL +RI QL I S VKA + + L+
Sbjct: 762 -VADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQA 820
Query: 1095 AQNLMQSVKETVREAEAASIKIRTDAGF------TLRWVRKTP 1131
A+NLM +V TV+ + AS K + G + W K P
Sbjct: 821 AKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAP 863
Score = 85.9 bits (211), Expect = 2e-16
Identities = 87/377 (23%), Positives = 159/377 (42%), Gaps = 25/377 (6%)
Query: 6 TRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPV--AAVQAAVSNLVRVGKETVQ 63
T T+E +LEP+ Q++ LV +G K A V A+V+ A N + G++ +
Sbjct: 21 TLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHVLAASVEQATQNFLEKGEQIAK 80
Query: 64 TTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLL 123
++D LK ++ A V + A+ DP S R ++ +R +LS + LL
Sbjct: 81 ESQD--LKEELVAAVEDVRKQGETMRIASSEFADDPCSSVKRGTMVRAARALLSAVTRLL 138
Query: 124 LTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELT 183
+ D A+V +++ K + E L + +DL K G M K+ + RQQEL
Sbjct: 139 ILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELK 198
Query: 184 HQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINE 243
R + + +K+ +L +A + F+ ++ + NR++ +++ I
Sbjct: 199 DPHCRDEMAAARGALKKNATMLYTASQAFL-----RHPDVAATRANRDYVFKQVQEAIAG 253
Query: 244 IIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDP----SASPGDAGEQAI 299
I Q TS ++A + AL D+K+ + DP A + E+ +
Sbjct: 254 ISNAAQATSPTDEAKGHTGIGELAAALNEFDNKI------ILDPMTFSEARFRPSLEERL 307
Query: 300 RQILDEAGKVGE-LCAGKERRE-ILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVS 357
I+ A + + C +RRE I+ C + Q + G +K ++
Sbjct: 308 ESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNTGRK----EKGDPLN 363
Query: 358 QGLDVLTAKVENAARKL 374
+D +T K + R+L
Sbjct: 364 IAIDKMTKKTRDLRRQL 380
>gi|55770844 catenin, alpha 1 [Homo sapiens]
Length = 906
Score = 114 bits (284), Expect = 7e-25
Identities = 85/305 (27%), Positives = 144/305 (47%), Gaps = 14/305 (4%)
Query: 538 RQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLK---DLKARMQEAMTQE 594
R+ ++A+C+ V Q L G ++ AL S + K DL+ ++++A+
Sbjct: 330 RERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDH 389
Query: 595 VSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTAN 654
VSD F +T P+ +L AA N +EV E A F H+ KL A A ++ N
Sbjct: 390 VSDSFLETNVPLLVLIEAAKNG----NEKEV-KEYAQVFREHANKLIEVANLACSISN-N 443
Query: 655 KSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVD 714
+ V+ ++ S L PQV++AA L P ++ A E+ + K QW V +T VD
Sbjct: 444 EEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVD 503
Query: 715 EAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENS 774
+ L SE I +D++KC +A+ L A +I RA R++ V E++N
Sbjct: 504 DITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNY 563
Query: 775 EDPKFREAVKAASDELSKTISPMVMD-----AKAVAGNISDPGLQKSFLDSGYRILGAVA 829
E + E V A+ LS T+ P + +A++ + + P + F+D+ + +
Sbjct: 564 EPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIR 623
Query: 830 KVREA 834
+R+A
Sbjct: 624 DIRKA 628
Score = 85.5 bits (210), Expect = 3e-16
Identities = 57/170 (33%), Positives = 83/170 (48%), Gaps = 14/170 (8%)
Query: 973 LHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRA--LIQCAKDIAKASDEVT 1030
L E +KW GNDII AK+M ++M EM+ RG K +I AK IA+A +
Sbjct: 698 LDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMD 757
Query: 1031 RLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKA---TMLGRTNISDEESEQA 1087
+L + +A C D + +LL +RI QL I S VKA + G +S +S +
Sbjct: 758 KLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMS 817
Query: 1088 TEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGF------TLRWVRKTP 1131
L+ A+NLM +V +TV+ + AS K + G + W K P
Sbjct: 818 ---LIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAP 864
Score = 76.6 bits (187), Expect = 1e-13
Identities = 85/378 (22%), Positives = 166/378 (43%), Gaps = 26/378 (6%)
Query: 6 TRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPV--AAVQAAVSNLVRVGKETVQ 63
T +E +LEP+ Q++ LV + +G + K A V A+V+ A N + G + +
Sbjct: 22 TLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAK 81
Query: 64 TTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLL 123
E Q LK ++ A V + AA DP S R ++ +R +LS + LL
Sbjct: 82 --ESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLL 139
Query: 124 LTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELT 183
+ D A+V K++ K + + + +DL K L P + K+ M +RQQEL
Sbjct: 140 ILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELK 199
Query: 184 HQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINE 243
HR + + +++ +P+L +A + + ++ + NR+ +++ +
Sbjct: 200 DVGHRDQMAAARGILQKNVPILYTASQACL-----QHPDVAAYKANRDLIYKQLQQAVTG 254
Query: 244 IIRVLQLTSWDE-DAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGD----AGEQA 298
I Q T+ D+ + AL + D ++ + DP + + + E+
Sbjct: 255 ISNAAQATASDDASQHQGGGGGELAYALNNFDKQI------IVDPLSFSEERFRPSLEER 308
Query: 299 IRQILDEAGKVGE-LCAGKERRE-ILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQV 356
+ I+ A + + C +RRE I+ C + Q + DL + G++ +++ +
Sbjct: 309 LESIISGAALMADSSCTRDDRRERIVAECNAVRQ---ALQDLLSEYMGNAG-RKERSDAL 364
Query: 357 SQGLDVLTAKVENAARKL 374
+ +D +T K + R+L
Sbjct: 365 NSAIDKMTKKTRDLRRQL 382
>gi|188497718 catenin, alpha 3 [Homo sapiens]
Length = 895
Score = 107 bits (268), Expect = 5e-23
Identities = 100/405 (24%), Positives = 176/405 (43%), Gaps = 32/405 (7%)
Query: 402 PEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARA 461
P ++I GA A KE +L S+ S +A L+ E +
Sbjct: 198 PNQRDEIAGARASL----------KENSPLLHSICSACLEHSDVASLKASKDTVCEEIQN 247
Query: 462 LAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWID-NP-TVDDRGVGQAAI 519
++ A Q +Q T + P A L +++ + I NP TV + + +
Sbjct: 248 ALNVISNASQGIQNMT------TPPEPQAATLGSALDELENLIVLNPLTVTEEEIRPSLE 301
Query: 520 RGLVA--EGHRL---ANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALAS 574
+ L A G L ++ +R+ ++A+C+ + Q L G+ ++ L
Sbjct: 302 KRLEAIISGAALLADSSCTRDLHRERIIAECNAIRQALQDLLSEYMNNAGKKERSNTLNI 361
Query: 575 QLQDSLK---DLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAA 631
L + K DL+ ++++A+ VSD F DTT P+ +L AA RE+ E AA
Sbjct: 362 ALDNMCKKTRDLRRQLRKAIIDHVSDSFLDTTVPLLVLIEAAKN-----GREKEIKEYAA 416
Query: 632 NFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAA 691
F H+ +L A A ++ T N+ ++ ++ + L PQ+++AA L P +QA
Sbjct: 417 IFHEHTSRLVEVANLACSMST-NEDGIKIVKIAANHLETLCPQIINAALALAARPKSQAV 475
Query: 692 YEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVA 751
E K W +++ +T VD+ L SE I +D++KC +A+ + L
Sbjct: 476 KNTMEMYKRTWENHIHVLTEAVDDITSIDDFLAVSESHILEDVNKCIIALRDQDADNLDR 535
Query: 752 GATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISP 796
A +I RA R+ + E+++ E + E V + L+ T+ P
Sbjct: 536 AAGAIRGRAARVAHIVTGEMDSYEPGAYTEGVMRNVNFLTSTVIP 580
Score = 78.2 bits (191), Expect = 4e-14
Identities = 51/146 (34%), Positives = 74/146 (50%), Gaps = 2/146 (1%)
Query: 973 LHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRA--LIQCAKDIAKASDEVT 1030
L E W NDII AK M ++M EM+ RG K +I AK I+++ +
Sbjct: 687 LDAEIEIWDDTSNDIIVLAKNMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISESGSRMD 746
Query: 1031 RLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEM 1090
LA+++A QC D + +LL E+I S QLKI S VKA + + +
Sbjct: 747 VLARQIANQCPDPSCKQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIMSALDSVTS 806
Query: 1091 LVHNAQNLMQSVKETVREAEAASIKI 1116
L+ A+NLM +V +TV+ + AS KI
Sbjct: 807 LIQAAKNLMNAVVQTVKMSYIASTKI 832
Score = 59.7 bits (143), Expect = 2e-08
Identities = 48/203 (23%), Positives = 93/203 (45%), Gaps = 3/203 (1%)
Query: 6 TRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPV-AAVQAAVSNLVRVGKETVQT 64
T T+E +LEP+ Q++ LV + K + + A+V+ A NL+ G++ Q
Sbjct: 20 TFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLASVEEATWNLLDKGEKIAQ- 78
Query: 65 TEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLL 124
E +LK ++ + +V L +A+ DP +P R+ ++ +R +L+ + LL+
Sbjct: 79 -EATVLKDELTASLEEVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLI 137
Query: 125 TFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTH 184
D +V +++ + V DL + LG + + + +RQQ+L
Sbjct: 138 LADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFKRQQDLKS 197
Query: 185 QEHRVMLVNSMNTVKELLPVLIS 207
R + + ++KE P+L S
Sbjct: 198 PNQRDEIAGARASLKENSPLLHS 220
>gi|188497716 catenin, alpha 3 [Homo sapiens]
Length = 895
Score = 107 bits (268), Expect = 5e-23
Identities = 100/405 (24%), Positives = 176/405 (43%), Gaps = 32/405 (7%)
Query: 402 PEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARA 461
P ++I GA A KE +L S+ S +A L+ E +
Sbjct: 198 PNQRDEIAGARASL----------KENSPLLHSICSACLEHSDVASLKASKDTVCEEIQN 247
Query: 462 LAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWID-NP-TVDDRGVGQAAI 519
++ A Q +Q T + P A L +++ + I NP TV + + +
Sbjct: 248 ALNVISNASQGIQNMT------TPPEPQAATLGSALDELENLIVLNPLTVTEEEIRPSLE 301
Query: 520 RGLVA--EGHRL---ANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALAS 574
+ L A G L ++ +R+ ++A+C+ + Q L G+ ++ L
Sbjct: 302 KRLEAIISGAALLADSSCTRDLHRERIIAECNAIRQALQDLLSEYMNNAGKKERSNTLNI 361
Query: 575 QLQDSLK---DLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAA 631
L + K DL+ ++++A+ VSD F DTT P+ +L AA RE+ E AA
Sbjct: 362 ALDNMCKKTRDLRRQLRKAIIDHVSDSFLDTTVPLLVLIEAAKN-----GREKEIKEYAA 416
Query: 632 NFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAA 691
F H+ +L A A ++ T N+ ++ ++ + L PQ+++AA L P +QA
Sbjct: 417 IFHEHTSRLVEVANLACSMST-NEDGIKIVKIAANHLETLCPQIINAALALAARPKSQAV 475
Query: 692 YEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVA 751
E K W +++ +T VD+ L SE I +D++KC +A+ + L
Sbjct: 476 KNTMEMYKRTWENHIHVLTEAVDDITSIDDFLAVSESHILEDVNKCIIALRDQDADNLDR 535
Query: 752 GATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISP 796
A +I RA R+ + E+++ E + E V + L+ T+ P
Sbjct: 536 AAGAIRGRAARVAHIVTGEMDSYEPGAYTEGVMRNVNFLTSTVIP 580
Score = 78.2 bits (191), Expect = 4e-14
Identities = 51/146 (34%), Positives = 74/146 (50%), Gaps = 2/146 (1%)
Query: 973 LHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRA--LIQCAKDIAKASDEVT 1030
L E W NDII AK M ++M EM+ RG K +I AK I+++ +
Sbjct: 687 LDAEIEIWDDTSNDIIVLAKNMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISESGSRMD 746
Query: 1031 RLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEM 1090
LA+++A QC D + +LL E+I S QLKI S VKA + + +
Sbjct: 747 VLARQIANQCPDPSCKQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIMSALDSVTS 806
Query: 1091 LVHNAQNLMQSVKETVREAEAASIKI 1116
L+ A+NLM +V +TV+ + AS KI
Sbjct: 807 LIQAAKNLMNAVVQTVKMSYIASTKI 832
Score = 59.7 bits (143), Expect = 2e-08
Identities = 48/203 (23%), Positives = 93/203 (45%), Gaps = 3/203 (1%)
Query: 6 TRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPV-AAVQAAVSNLVRVGKETVQT 64
T T+E +LEP+ Q++ LV + K + + A+V+ A NL+ G++ Q
Sbjct: 20 TFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLASVEEATWNLLDKGEKIAQ- 78
Query: 65 TEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLL 124
E +LK ++ + +V L +A+ DP +P R+ ++ +R +L+ + LL+
Sbjct: 79 -EATVLKDELTASLEEVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLI 137
Query: 125 TFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTH 184
D +V +++ + V DL + LG + + + +RQQ+L
Sbjct: 138 LADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFKRQQDLKS 197
Query: 185 QEHRVMLVNSMNTVKELLPVLIS 207
R + + ++KE P+L S
Sbjct: 198 PNQRDEIAGARASLKENSPLLHS 220
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 54.3 bits (129), Expect = 6e-07
Identities = 192/1035 (18%), Positives = 383/1035 (37%), Gaps = 154/1035 (14%)
Query: 142 LEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQEL-THQEHRVMLVNSMNTVKE 200
LE +T ++ +ED + + ++K K+++ER +L T+ ++ +K
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 201 LLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWAS 260
+IS +++ + + Q +E+ LK + +E +++ +E I LQ + +
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEK-LKRK---LEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 261 KDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERRE 320
K E ++ ALA +D ++ Q L+ G + +++ LD + + A K++R+
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISD--LQEDLD-SERAARNKAEKQKRD 1143
Query: 321 ILGTCKMLGQMTDQVAD-------LRARGQGSSPV---------------AMQKAQQVSQ 358
+ + L + D LRA+ + V + Q+ +Q
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 359 GLDVLTAKVENAARKLEAMTNSKQSIAKK-IDAAQNWLADPNGGPEGEEQIRGALAEARK 417
++ LT ++E R + +KQ++ K+ D A E E + + A+ ++
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 418 IAELCDDPKE-----RDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQN 472
+ C D + D + + E+ ++T L + +GK A LAK VA+
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGK-----AIKLAKDVASLSSQ 1316
Query: 473 LQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANV 532
LQ +R +++ K+ Q + + ++ D+ + + + N+
Sbjct: 1317 LQDTQELLQEETR---QKLNVSTKLRQLEE--ERNSLQDQLDEEMEAKQNLERHISTLNI 1371
Query: 533 MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMT 592
+ ++ L V+ L E + Q A+ D L+ K R+Q
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQ---- 1426
Query: 593 QEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGT 652
QE+ D+ D +L++ + ++ FD+ A +N S K ++A A
Sbjct: 1427 QELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEA--- 1476
Query: 653 ANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGL 712
ARE + +S AR L A E E +E +
Sbjct: 1477 --------------EAREKETKALSLARAL---EEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 713 VDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILL------- 765
D+ L+ S+ A++ +++ K + ++ ++ + N L
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 766 VAKREVENSEDPK-FREAVKAASDELSKTISPMVMDA---KAVAGNISDPGLQKSFLDSG 821
+ R+ +N E + + + EL + A K + G++ D LQ DS
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ---ADSA 1636
Query: 822 YRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEK 881
+ K Q Q DF Q L D A +
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDF--------QRELEDARA--------------------SR 1668
Query: 882 DEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPV 941
DE F K E + + QL ++ +++ A++ +AE A+ +G
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLA--AAERARKQADLEKEELAEELASSLSGRNA 1726
Query: 942 PPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAA---------- 991
D + E + + Q + A R+AT+ + + ++ +A
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 992 --------KRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCT-- 1041
K + + EM V+ S K + IA+ ++V + A+E KQ
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEARE--KQAATK 1842
Query: 1042 -----DKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQ 1096
DK+++ LLQV E ++ Q K + + + EE+E+ ++ + N +
Sbjct: 1843 SLKQKDKKLKEILLQV-EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Query: 1097 NLMQSVKETVREAEA 1111
L + + E EA
Sbjct: 1902 KLQRELDEATESNEA 1916
Score = 47.0 bits (110), Expect = 1e-04
Identities = 164/812 (20%), Positives = 326/812 (40%), Gaps = 105/812 (12%)
Query: 21 SHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILK--RDMPPAF 78
SH + E + +A+ +LT + + A +NL + K+T++ + R + A
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-NKQTLEKENADLAGELRVLGQAK 1247
Query: 79 IKVENACTKLVQAAQMLQSD-PYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRV 137
+VE+ KL Q LQS AR L D + + + +EAE K I++
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE-GKAIKL 1306
Query: 138 CKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDER---QQELTHQ-EHRVMLVN 193
K + + ++ +T E L T+ TK+ ++ +ER Q +L + E + L
Sbjct: 1307 AKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 194 SMNTVKELLPVLISAMKIFVTTKNSKNQG---IEEALKNRNFTVEKMSAEINEIIRVLQL 250
++T+ L ++ F +T + +G ++ ++N E+ +A +++ +
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 251 TSWDEDAWASKDTEAMKRALASIDSK---LNQAKGWLRDPSASPGDAGEQAIRQILDEAG 307
+ D D + ++ +++++ K +Q ++ S+ D ++A + ++
Sbjct: 1425 LQQELDDLVV-DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 308 KVGELCAGKE-----RREILGTCKML-GQMTDQVADLRARGQGSSPVAMQKAQQVSQGLD 361
K L E + E+ T KML +M D V+ G+ + K +Q ++
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-ME 1542
Query: 362 VLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAEL 421
+ ++E +L+A ++K + + A + G E + Q R E
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALK-------GQFERDLQARDEQNE------- 1588
Query: 422 CDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAV 481
++R + R L E ++L D R+Q A A K++ L++L+ + + A+
Sbjct: 1589 ----EKRRQLQRQLHEYE---TELEDERKQ----RALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 482 ANSRPA-KAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQ- 539
A K L+ +++ QR ++D + I E + A + Q
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 540 -DLLAKCDRV--------DQLTAQLAD-LAARG--EGESPQARALASQLQDSLKDLKARM 587
+ LA +R ++L +LA L+ R + E + A +QL++ L++ + M
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1752
Query: 588 QEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKA 647
EAM+ V T +L AT A E + + KL E
Sbjct: 1753 -EAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH---EME 1805
Query: 648 AAVGTANKSTVEGIQASVKTARELTPQVVSAAR------------------ILLRNPGNQ 689
AV + KST+ ++A + +L QV AR ILL+ +
Sbjct: 1806 GAVKSKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Query: 690 AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQML 749
E ++ + V+++ ++EA + ++A+ ++++LD + +N
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD--EATESNEAMGRE 1920
Query: 750 VAGATSIARRANRILLV------AKREVENSE 775
V S RR N V +R +EN++
Sbjct: 1921 VNALKSKLRRGNETSFVPSRRSGGRRVIENAD 1952
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 54.3 bits (129), Expect = 6e-07
Identities = 192/1035 (18%), Positives = 383/1035 (37%), Gaps = 154/1035 (14%)
Query: 142 LEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQEL-THQEHRVMLVNSMNTVKE 200
LE +T ++ +ED + + ++K K+++ER +L T+ ++ +K
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 201 LLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWAS 260
+IS +++ + + Q +E+ LK + +E +++ +E I LQ + +
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEK-LKRK---LEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 261 KDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERRE 320
K E ++ ALA +D ++ Q L+ G + +++ LD + + A K++R+
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISD--LQEDLD-SERAARNKAEKQKRD 1150
Query: 321 ILGTCKMLGQMTDQVAD-------LRARGQGSSPV---------------AMQKAQQVSQ 358
+ + L + D LRA+ + V + Q+ +Q
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 359 GLDVLTAKVENAARKLEAMTNSKQSIAKK-IDAAQNWLADPNGGPEGEEQIRGALAEARK 417
++ LT ++E R + +KQ++ K+ D A E E + + A+ ++
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 418 IAELCDDPKE-----RDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQN 472
+ C D + D + + E+ ++T L + +GK A LAK VA+
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGK-----AIKLAKDVASLSSQ 1323
Query: 473 LQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANV 532
LQ +R +++ K+ Q + + ++ D+ + + + N+
Sbjct: 1324 LQDTQELLQEETR---QKLNVSTKLRQLEE--ERNSLQDQLDEEMEAKQNLERHISTLNI 1378
Query: 533 MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMT 592
+ ++ L V+ L E + Q A+ D L+ K R+Q
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQ---- 1433
Query: 593 QEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGT 652
QE+ D+ D +L++ + ++ FD+ A +N S K ++A A
Sbjct: 1434 QELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEA--- 1483
Query: 653 ANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGL 712
ARE + +S AR L A E E +E +
Sbjct: 1484 --------------EAREKETKALSLARAL---EEALEAKEELERTNKMLKAEMEDLVSS 1526
Query: 713 VDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILL------- 765
D+ L+ S+ A++ +++ K + ++ ++ + N L
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 766 VAKREVENSEDPK-FREAVKAASDELSKTISPMVMDA---KAVAGNISDPGLQKSFLDSG 821
+ R+ +N E + + + EL + A K + G++ D LQ DS
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ---ADSA 1643
Query: 822 YRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEK 881
+ K Q Q DF Q L D A +
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDF--------QRELEDARA--------------------SR 1675
Query: 882 DEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPV 941
DE F K E + + QL ++ +++ A++ +AE A+ +G
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLA--AAERARKQADLEKEELAEELASSLSGRNA 1733
Query: 942 PPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAA---------- 991
D + E + + Q + A R+AT+ + + ++ +A
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 992 --------KRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCT-- 1041
K + + EM V+ S K + IA+ ++V + A+E KQ
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEARE--KQAATK 1849
Query: 1042 -----DKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQ 1096
DK+++ LLQV E ++ Q K + + + EE+E+ ++ + N +
Sbjct: 1850 SLKQKDKKLKEILLQV-EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Query: 1097 NLMQSVKETVREAEA 1111
L + + E EA
Sbjct: 1909 KLQRELDEATESNEA 1923
Score = 47.0 bits (110), Expect = 1e-04
Identities = 164/812 (20%), Positives = 326/812 (40%), Gaps = 105/812 (12%)
Query: 21 SHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILK--RDMPPAF 78
SH + E + +A+ +LT + + A +NL + K+T++ + R + A
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-NKQTLEKENADLAGELRVLGQAK 1254
Query: 79 IKVENACTKLVQAAQMLQSD-PYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRV 137
+VE+ KL Q LQS AR L D + + + +EAE K I++
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE-GKAIKL 1313
Query: 138 CKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDER---QQELTHQ-EHRVMLVN 193
K + + ++ +T E L T+ TK+ ++ +ER Q +L + E + L
Sbjct: 1314 AKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 194 SMNTVKELLPVLISAMKIFVTTKNSKNQG---IEEALKNRNFTVEKMSAEINEIIRVLQL 250
++T+ L ++ F +T + +G ++ ++N E+ +A +++ +
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 251 TSWDEDAWASKDTEAMKRALASIDSK---LNQAKGWLRDPSASPGDAGEQAIRQILDEAG 307
+ D D + ++ +++++ K +Q ++ S+ D ++A + ++
Sbjct: 1432 LQQELDDLVV-DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 308 KVGELCAGKE-----RREILGTCKML-GQMTDQVADLRARGQGSSPVAMQKAQQVSQGLD 361
K L E + E+ T KML +M D V+ G+ + K +Q ++
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-ME 1549
Query: 362 VLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAEL 421
+ ++E +L+A ++K + + A + G E + Q R E
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALK-------GQFERDLQARDEQNE------- 1595
Query: 422 CDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAV 481
++R + R L E ++L D R+Q A A K++ L++L+ + + A+
Sbjct: 1596 ----EKRRQLQRQLHEYE---TELEDERKQ----RALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 482 ANSRPA-KAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQ- 539
A K L+ +++ QR ++D + I E + A + Q
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 540 -DLLAKCDRV--------DQLTAQLAD-LAARG--EGESPQARALASQLQDSLKDLKARM 587
+ LA +R ++L +LA L+ R + E + A +QL++ L++ + M
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1759
Query: 588 QEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKA 647
EAM+ V T +L AT A E + + KL E
Sbjct: 1760 -EAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH---EME 1812
Query: 648 AAVGTANKSTVEGIQASVKTARELTPQVVSAAR------------------ILLRNPGNQ 689
AV + KST+ ++A + +L QV AR ILL+ +
Sbjct: 1813 GAVKSKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Query: 690 AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQML 749
E ++ + V+++ ++EA + ++A+ ++++LD + +N
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD--EATESNEAMGRE 1927
Query: 750 VAGATSIARRANRILLV------AKREVENSE 775
V S RR N V +R +EN++
Sbjct: 1928 VNALKSKLRRGNETSFVPSRRSGGRRVIENAD 1959
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 54.3 bits (129), Expect = 6e-07
Identities = 192/1035 (18%), Positives = 383/1035 (37%), Gaps = 154/1035 (14%)
Query: 142 LEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQEL-THQEHRVMLVNSMNTVKE 200
LE +T ++ +ED + + ++K K+++ER +L T+ ++ +K
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 201 LLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWAS 260
+IS +++ + + Q +E+ LK + +E +++ +E I LQ + +
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEK-LKRK---LEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 261 KDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERRE 320
K E ++ ALA +D ++ Q L+ G + +++ LD + + A K++R+
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISD--LQEDLD-SERAARNKAEKQKRD 1150
Query: 321 ILGTCKMLGQMTDQVAD-------LRARGQGSSPV---------------AMQKAQQVSQ 358
+ + L + D LRA+ + V + Q+ +Q
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 359 GLDVLTAKVENAARKLEAMTNSKQSIAKK-IDAAQNWLADPNGGPEGEEQIRGALAEARK 417
++ LT ++E R + +KQ++ K+ D A E E + + A+ ++
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 418 IAELCDDPKE-----RDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQN 472
+ C D + D + + E+ ++T L + +GK A LAK VA+
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGK-----AIKLAKDVASLSSQ 1323
Query: 473 LQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANV 532
LQ +R +++ K+ Q + + ++ D+ + + + N+
Sbjct: 1324 LQDTQELLQEETR---QKLNVSTKLRQLEE--ERNSLQDQLDEEMEAKQNLERHISTLNI 1378
Query: 533 MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMT 592
+ ++ L V+ L E + Q A+ D L+ K R+Q
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQ---- 1433
Query: 593 QEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGT 652
QE+ D+ D +L++ + ++ FD+ A +N S K ++A A
Sbjct: 1434 QELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEA--- 1483
Query: 653 ANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGL 712
ARE + +S AR L A E E +E +
Sbjct: 1484 --------------EAREKETKALSLARAL---EEALEAKEELERTNKMLKAEMEDLVSS 1526
Query: 713 VDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILL------- 765
D+ L+ S+ A++ +++ K + ++ ++ + N L
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 766 VAKREVENSEDPK-FREAVKAASDELSKTISPMVMDA---KAVAGNISDPGLQKSFLDSG 821
+ R+ +N E + + + EL + A K + G++ D LQ DS
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ---ADSA 1643
Query: 822 YRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEK 881
+ K Q Q DF Q L D A +
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDF--------QRELEDARA--------------------SR 1675
Query: 882 DEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPV 941
DE F K E + + QL ++ +++ A++ +AE A+ +G
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLA--AAERARKQADLEKEELAEELASSLSGRNA 1733
Query: 942 PPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAA---------- 991
D + E + + Q + A R+AT+ + + ++ +A
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 992 --------KRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCT-- 1041
K + + EM V+ S K + IA+ ++V + A+E KQ
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEARE--KQAATK 1849
Query: 1042 -----DKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQ 1096
DK+++ LLQV E ++ Q K + + + EE+E+ ++ + N +
Sbjct: 1850 SLKQKDKKLKEILLQV-EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Query: 1097 NLMQSVKETVREAEA 1111
L + + E EA
Sbjct: 1909 KLQRELDEATESNEA 1923
Score = 46.2 bits (108), Expect = 2e-04
Identities = 154/767 (20%), Positives = 311/767 (40%), Gaps = 97/767 (12%)
Query: 21 SHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILK--RDMPPAF 78
SH + E + +A+ +LT + + A +NL + K+T++ + R + A
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-NKQTLEKENADLAGELRVLGQAK 1254
Query: 79 IKVENACTKLVQAAQMLQSD-PYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRV 137
+VE+ KL Q LQS AR L D + + + +EAE K I++
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE-GKAIKL 1313
Query: 138 CKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDER---QQELTHQ-EHRVMLVN 193
K + + ++ +T E L T+ TK+ ++ +ER Q +L + E + L
Sbjct: 1314 AKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 194 SMNTVKELLPVLISAMKIFVTTKNSKNQG---IEEALKNRNFTVEKMSAEINEIIRVLQL 250
++T+ L ++ F +T + +G ++ ++N E+ +A +++ +
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 251 TSWDEDAWASKDTEAMKRALASIDSK---LNQAKGWLRDPSASPGDAGEQAIRQILDEAG 307
+ D D + ++ +++++ K +Q ++ S+ D ++A + ++
Sbjct: 1432 LQQELDDLVV-DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 308 KVGELCAGKE-----RREILGTCKML-GQMTDQVADLRARGQGSSPVAMQKAQQVSQGLD 361
K L E + E+ T KML +M D V+ G+ + K +Q ++
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-ME 1549
Query: 362 VLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAEL 421
+ ++E +L+A ++K + + A + G E + Q R E
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALK-------GQFERDLQARDEQNE------- 1595
Query: 422 CDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAV 481
++R + R L E ++L D R+Q A A K++ L++L+ + + A+
Sbjct: 1596 ----EKRRQLQRQLHEYE---TELEDERKQ----RALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 482 ANSRPA-KAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQ- 539
A K L+ +++ QR ++D + I E + A + Q
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 540 -DLLAKCDRV--------DQLTAQLAD-LAARG--EGESPQARALASQLQDSLKDLKARM 587
+ LA +R ++L +LA L+ R + E + A +QL++ L++ + M
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1759
Query: 588 QEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKA 647
EAM+ V T +L AT A E + + KL E
Sbjct: 1760 -EAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH---EME 1812
Query: 648 AAVGTANKSTVEGIQASVKTARELTPQVVSAAR------------------ILLRNPGNQ 689
AV + KST+ ++A + +L QV AR ILL+ +
Sbjct: 1813 GAVKSKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Query: 690 AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDK 736
E ++ + V+++ ++EA + ++A+ ++++LD+
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 54.3 bits (129), Expect = 6e-07
Identities = 192/1035 (18%), Positives = 383/1035 (37%), Gaps = 154/1035 (14%)
Query: 142 LEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQEL-THQEHRVMLVNSMNTVKE 200
LE +T ++ +ED + + ++K K+++ER +L T+ ++ +K
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 201 LLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWAS 260
+IS +++ + + Q +E+ LK + +E +++ +E I LQ + +
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEK-LKRK---LEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 261 KDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERRE 320
K E ++ ALA +D ++ Q L+ G + +++ LD + + A K++R+
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISD--LQEDLD-SERAARNKAEKQKRD 1143
Query: 321 ILGTCKMLGQMTDQVAD-------LRARGQGSSPV---------------AMQKAQQVSQ 358
+ + L + D LRA+ + V + Q+ +Q
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 359 GLDVLTAKVENAARKLEAMTNSKQSIAKK-IDAAQNWLADPNGGPEGEEQIRGALAEARK 417
++ LT ++E R + +KQ++ K+ D A E E + + A+ ++
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 418 IAELCDDPKE-----RDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQN 472
+ C D + D + + E+ ++T L + +GK A LAK VA+
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGK-----AIKLAKDVASLSSQ 1316
Query: 473 LQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANV 532
LQ +R +++ K+ Q + + ++ D+ + + + N+
Sbjct: 1317 LQDTQELLQEETR---QKLNVSTKLRQLEE--ERNSLQDQLDEEMEAKQNLERHISTLNI 1371
Query: 533 MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMT 592
+ ++ L V+ L E + Q A+ D L+ K R+Q
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQ---- 1426
Query: 593 QEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGT 652
QE+ D+ D +L++ + ++ FD+ A +N S K ++A A
Sbjct: 1427 QELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEA--- 1476
Query: 653 ANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGL 712
ARE + +S AR L A E E +E +
Sbjct: 1477 --------------EAREKETKALSLARAL---EEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 713 VDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILL------- 765
D+ L+ S+ A++ +++ K + ++ ++ + N L
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 766 VAKREVENSEDPK-FREAVKAASDELSKTISPMVMDA---KAVAGNISDPGLQKSFLDSG 821
+ R+ +N E + + + EL + A K + G++ D LQ DS
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ---ADSA 1636
Query: 822 YRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEK 881
+ K Q Q DF Q L D A +
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDF--------QRELEDARA--------------------SR 1668
Query: 882 DEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPV 941
DE F K E + + QL ++ +++ A++ +AE A+ +G
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLA--AAERARKQADLEKEELAEELASSLSGRNA 1726
Query: 942 PPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAA---------- 991
D + E + + Q + A R+AT+ + + ++ +A
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 992 --------KRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCT-- 1041
K + + EM V+ S K + IA+ ++V + A+E KQ
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEARE--KQAATK 1842
Query: 1042 -----DKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQ 1096
DK+++ LLQV E ++ Q K + + + EE+E+ ++ + N +
Sbjct: 1843 SLKQKDKKLKEILLQV-EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Query: 1097 NLMQSVKETVREAEA 1111
L + + E EA
Sbjct: 1902 KLQRELDEATESNEA 1916
Score = 46.2 bits (108), Expect = 2e-04
Identities = 154/767 (20%), Positives = 311/767 (40%), Gaps = 97/767 (12%)
Query: 21 SHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILK--RDMPPAF 78
SH + E + +A+ +LT + + A +NL + K+T++ + R + A
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-NKQTLEKENADLAGELRVLGQAK 1247
Query: 79 IKVENACTKLVQAAQMLQSD-PYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRV 137
+VE+ KL Q LQS AR L D + + + +EAE K I++
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE-GKAIKL 1306
Query: 138 CKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDER---QQELTHQ-EHRVMLVN 193
K + + ++ +T E L T+ TK+ ++ +ER Q +L + E + L
Sbjct: 1307 AKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 194 SMNTVKELLPVLISAMKIFVTTKNSKNQG---IEEALKNRNFTVEKMSAEINEIIRVLQL 250
++T+ L ++ F +T + +G ++ ++N E+ +A +++ +
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 251 TSWDEDAWASKDTEAMKRALASIDSK---LNQAKGWLRDPSASPGDAGEQAIRQILDEAG 307
+ D D + ++ +++++ K +Q ++ S+ D ++A + ++
Sbjct: 1425 LQQELDDLVV-DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 308 KVGELCAGKE-----RREILGTCKML-GQMTDQVADLRARGQGSSPVAMQKAQQVSQGLD 361
K L E + E+ T KML +M D V+ G+ + K +Q ++
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-ME 1542
Query: 362 VLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAEL 421
+ ++E +L+A ++K + + A + G E + Q R E
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALK-------GQFERDLQARDEQNE------- 1588
Query: 422 CDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAV 481
++R + R L E ++L D R+Q A A K++ L++L+ + + A+
Sbjct: 1589 ----EKRRQLQRQLHEYE---TELEDERKQ----RALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 482 ANSRPA-KAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQ- 539
A K L+ +++ QR ++D + I E + A + Q
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 540 -DLLAKCDRV--------DQLTAQLAD-LAARG--EGESPQARALASQLQDSLKDLKARM 587
+ LA +R ++L +LA L+ R + E + A +QL++ L++ + M
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1752
Query: 588 QEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKA 647
EAM+ V T +L AT A E + + KL E
Sbjct: 1753 -EAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH---EME 1805
Query: 648 AAVGTANKSTVEGIQASVKTARELTPQVVSAAR------------------ILLRNPGNQ 689
AV + KST+ ++A + +L QV AR ILL+ +
Sbjct: 1806 GAVKSKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Query: 690 AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDK 736
E ++ + V+++ ++EA + ++A+ ++++LD+
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 54.3 bits (129), Expect = 6e-07
Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)
Query: 224 EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
EE ++ V+ + I E ++ L+ +S E ++ EA +R+ I+ ++ +
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 282 GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
L G A GE QA+R +EA + + A + RR++ + Q
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1515
Query: 337 DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
+L +R + + A +K Q+ Q L+ L + E A R+L +Q+ ++ Q L
Sbjct: 1516 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1568
Query: 397 DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
E E Q + A + A K A+L RSL E ++L + +
Sbjct: 1569 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 457 PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
EA ++ L+ Q K N A+ A+ A E + E+A+R
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677
Query: 505 --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
+ V R + + + + +AEG + L A+ ++ +Q L + A
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 561 RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
R + E+ A +L+ L ++A M+ +A +E S S+ + +
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 608 LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
LA A +A + ++ +E AA + ++ AEK AA+G A + E
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1855
Query: 662 ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
+A + R L R L A E ++ +E+ GLV++
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 716 AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
+ + ++ A+K +K A ++ ++ + + A R + L A +R++
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 772 ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
E+ + REA + K++A +K+ L+ R+ V +
Sbjct: 1976 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 832 REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
R + E + QL+L E A + EEK F Q+
Sbjct: 2022 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2062
Query: 892 EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
+ + Q + QL EA +++ AE V AE +AA +
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2111
Query: 949 YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
E E L + + AAA+ L +EA + +++ AA R AEM +
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
+ T R Q +++ +E+ RL E + + Q
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2225
Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
V E + ++ Q++ LS +KA + + D+++ Q L A+ + Q +E R
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2283
Query: 1109 AEAA 1112
+ AA
Sbjct: 2284 SVAA 2287
Score = 31.2 bits (69), Expect = 5.8
Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)
Query: 330 QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
++ + A L + Q + A KAQ + ++ E R+ EA +++Q
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1416
Query: 390 AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
+ Q L E E Q + AEA + + L + + R L+ + GE+
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 440 ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
AL ++ + Q + EA L +QV Q ++ + A R +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 489 AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
A L + E+A+R + V+ Q A+ R A + R K ++
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1592
Query: 549 DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
++ AQL + A R + +A + + L+ + + EA+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 54.3 bits (129), Expect = 6e-07
Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)
Query: 224 EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
EE ++ V+ + I E ++ L+ +S E ++ EA +R+ I+ ++ +
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Query: 282 GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
L G A GE QA+R +EA + + A + RR++ + Q
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1519
Query: 337 DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
+L +R + + A +K Q+ Q L+ L + E A R+L +Q+ ++ Q L
Sbjct: 1520 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1572
Query: 397 DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
E E Q + A + A K A+L RSL E ++L + +
Sbjct: 1573 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1621
Query: 457 PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
EA ++ L+ Q K N A+ A+ A E + E+A+R
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1681
Query: 505 --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
+ V R + + + + +AEG + L A+ ++ +Q L + A
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741
Query: 561 RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
R + E+ A +L+ L ++A M+ +A +E S S+ + +
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1801
Query: 608 LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
LA A +A + ++ +E AA + ++ AEK AA+G A + E
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1859
Query: 662 ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
+A + R L R L A E ++ +E+ GLV++
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919
Query: 716 AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
+ + ++ A+K +K A ++ ++ + + A R + L A +R++
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979
Query: 772 ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
E+ + REA + K++A +K+ L+ R+ V +
Sbjct: 1980 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 832 REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
R + E + QL+L E A + EEK F Q+
Sbjct: 2026 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2066
Query: 892 EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
+ + Q + QL EA +++ AE V AE +AA +
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2115
Query: 949 YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
E E L + + AAA+ L +EA + +++ AA R AEM +
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175
Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
+ T R Q +++ +E+ RL E + + Q
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2229
Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
V E + ++ Q++ LS +KA + + D+++ Q L A+ + Q +E R
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2287
Query: 1109 AEAA 1112
+ AA
Sbjct: 2288 SVAA 2291
Score = 31.2 bits (69), Expect = 5.8
Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)
Query: 330 QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
++ + A L + Q + A KAQ + ++ E R+ EA +++Q
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1420
Query: 390 AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
+ Q L E E Q + AEA + + L + + R L+ + GE+
Sbjct: 1421 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1480
Query: 440 ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
AL ++ + Q + EA L +QV Q ++ + A R +
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 489 AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
A L + E+A+R + V+ Q A+ R A + R K ++
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1596
Query: 549 DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
++ AQL + A R + +A + + L+ + + EA+
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 54.3 bits (129), Expect = 6e-07
Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)
Query: 224 EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
EE ++ V+ + I E ++ L+ +S E ++ EA +R+ I+ ++ +
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 282 GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
L G A GE QA+R +EA + + A + RR++ + Q
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1515
Query: 337 DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
+L +R + + A +K Q+ Q L+ L + E A R+L +Q+ ++ Q L
Sbjct: 1516 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1568
Query: 397 DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
E E Q + A + A K A+L RSL E ++L + +
Sbjct: 1569 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 457 PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
EA ++ L+ Q K N A+ A+ A E + E+A+R
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677
Query: 505 --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
+ V R + + + + +AEG + L A+ ++ +Q L + A
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 561 RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
R + E+ A +L+ L ++A M+ +A +E S S+ + +
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 608 LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
LA A +A + ++ +E AA + ++ AEK AA+G A + E
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1855
Query: 662 ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
+A + R L R L A E ++ +E+ GLV++
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 716 AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
+ + ++ A+K +K A ++ ++ + + A R + L A +R++
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 772 ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
E+ + REA + K++A +K+ L+ R+ V +
Sbjct: 1976 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 832 REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
R + E + QL+L E A + EEK F Q+
Sbjct: 2022 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2062
Query: 892 EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
+ + Q + QL EA +++ AE V AE +AA +
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2111
Query: 949 YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
E E L + + AAA+ L +EA + +++ AA R AEM +
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
+ T R Q +++ +E+ RL E + + Q
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2225
Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
V E + ++ Q++ LS +KA + + D+++ Q L A+ + Q +E R
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2283
Query: 1109 AEAA 1112
+ AA
Sbjct: 2284 SVAA 2287
Score = 31.2 bits (69), Expect = 5.8
Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)
Query: 330 QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
++ + A L + Q + A KAQ + ++ E R+ EA +++Q
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1416
Query: 390 AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
+ Q L E E Q + AEA + + L + + R L+ + GE+
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 440 ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
AL ++ + Q + EA L +QV Q ++ + A R +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 489 AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
A L + E+A+R + V+ Q A+ R A + R K ++
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1592
Query: 549 DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
++ AQL + A R + +A + + L+ + + EA+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 54.3 bits (129), Expect = 6e-07
Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)
Query: 224 EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
EE ++ V+ + I E ++ L+ +S E ++ EA +R+ I+ ++ +
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Query: 282 GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
L G A GE QA+R +EA + + A + RR++ + Q
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1483
Query: 337 DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
+L +R + + A +K Q+ Q L+ L + E A R+L +Q+ ++ Q L
Sbjct: 1484 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1536
Query: 397 DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
E E Q + A + A K A+L RSL E ++L + +
Sbjct: 1537 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1585
Query: 457 PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
EA ++ L+ Q K N A+ A+ A E + E+A+R
Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1645
Query: 505 --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
+ V R + + + + +AEG + L A+ ++ +Q L + A
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705
Query: 561 RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
R + E+ A +L+ L ++A M+ +A +E S S+ + +
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1765
Query: 608 LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
LA A +A + ++ +E AA + ++ AEK AA+G A + E
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1823
Query: 662 ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
+A + R L R L A E ++ +E+ GLV++
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883
Query: 716 AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
+ + ++ A+K +K A ++ ++ + + A R + L A +R++
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943
Query: 772 ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
E+ + REA + K++A +K+ L+ R+ V +
Sbjct: 1944 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Query: 832 REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
R + E + QL+L E A + EEK F Q+
Sbjct: 1990 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2030
Query: 892 EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
+ + Q + QL EA +++ AE V AE +AA +
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2079
Query: 949 YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
E E L + + AAA+ L +EA + +++ AA R AEM +
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139
Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
+ T R Q +++ +E+ RL E + + Q
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2193
Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
V E + ++ Q++ LS +KA + + D+++ Q L A+ + Q +E R
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2251
Query: 1109 AEAA 1112
+ AA
Sbjct: 2252 SVAA 2255
Score = 31.2 bits (69), Expect = 5.8
Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)
Query: 330 QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
++ + A L + Q + A KAQ + ++ E R+ EA +++Q
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1384
Query: 390 AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
+ Q L E E Q + AEA + + L + + R L+ + GE+
Sbjct: 1385 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1444
Query: 440 ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
AL ++ + Q + EA L +QV Q ++ + A R +
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Query: 489 AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
A L + E+A+R + V+ Q A+ R A + R K ++
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1560
Query: 549 DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
++ AQL + A R + +A + + L+ + + EA+
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 54.3 bits (129), Expect = 6e-07
Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)
Query: 224 EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
EE ++ V+ + I E ++ L+ +S E ++ EA +R+ I+ ++ +
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 282 GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
L G A GE QA+R +EA + + A + RR++ + Q
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1652
Query: 337 DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
+L +R + + A +K Q+ Q L+ L + E A R+L +Q+ ++ Q L
Sbjct: 1653 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1705
Query: 397 DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
E E Q + A + A K A+L RSL E ++L + +
Sbjct: 1706 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1754
Query: 457 PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
EA ++ L+ Q K N A+ A+ A E + E+A+R
Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1814
Query: 505 --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
+ V R + + + + +AEG + L A+ ++ +Q L + A
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874
Query: 561 RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
R + E+ A +L+ L ++A M+ +A +E S S+ + +
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1934
Query: 608 LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
LA A +A + ++ +E AA + ++ AEK AA+G A + E
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1992
Query: 662 ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
+A + R L R L A E ++ +E+ GLV++
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052
Query: 716 AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
+ + ++ A+K +K A ++ ++ + + A R + L A +R++
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112
Query: 772 ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
E+ + REA + K++A +K+ L+ R+ V +
Sbjct: 2113 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 832 REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
R + E + QL+L E A + EEK F Q+
Sbjct: 2159 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2199
Query: 892 EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
+ + Q + QL EA +++ AE V AE +AA +
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2248
Query: 949 YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
E E L + + AAA+ L +EA + +++ AA R AEM +
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308
Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
+ T R Q +++ +E+ RL E + + Q
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2362
Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
V E + ++ Q++ LS +KA + + D+++ Q L A+ + Q +E R
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2420
Query: 1109 AEAA 1112
+ AA
Sbjct: 2421 SVAA 2424
Score = 31.2 bits (69), Expect = 5.8
Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)
Query: 330 QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
++ + A L + Q + A KAQ + ++ E R+ EA +++Q
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1553
Query: 390 AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
+ Q L E E Q + AEA + + L + + R L+ + GE+
Sbjct: 1554 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1613
Query: 440 ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
AL ++ + Q + EA L +QV Q ++ + A R +
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Query: 489 AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
A L + E+A+R + V+ Q A+ R A + R K ++
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1729
Query: 549 DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
++ AQL + A R + +A + + L+ + + EA+
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 54.3 bits (129), Expect = 6e-07
Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)
Query: 224 EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
EE ++ V+ + I E ++ L+ +S E ++ EA +R+ I+ ++ +
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 282 GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
L G A GE QA+R +EA + + A + RR++ + Q
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1493
Query: 337 DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
+L +R + + A +K Q+ Q L+ L + E A R+L +Q+ ++ Q L
Sbjct: 1494 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1546
Query: 397 DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
E E Q + A + A K A+L RSL E ++L + +
Sbjct: 1547 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1595
Query: 457 PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
EA ++ L+ Q K N A+ A+ A E + E+A+R
Sbjct: 1596 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1655
Query: 505 --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
+ V R + + + + +AEG + L A+ ++ +Q L + A
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1715
Query: 561 RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
R + E+ A +L+ L ++A M+ +A +E S S+ + +
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1775
Query: 608 LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
LA A +A + ++ +E AA + ++ AEK AA+G A + E
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1833
Query: 662 ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
+A + R L R L A E ++ +E+ GLV++
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893
Query: 716 AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
+ + ++ A+K +K A ++ ++ + + A R + L A +R++
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953
Query: 772 ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
E+ + REA + K++A +K+ L+ R+ V +
Sbjct: 1954 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Query: 832 REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
R + E + QL+L E A + EEK F Q+
Sbjct: 2000 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2040
Query: 892 EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
+ + Q + QL EA +++ AE V AE +AA +
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2089
Query: 949 YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
E E L + + AAA+ L +EA + +++ AA R AEM +
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149
Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
+ T R Q +++ +E+ RL E + + Q
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2203
Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
V E + ++ Q++ LS +KA + + D+++ Q L A+ + Q +E R
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2261
Query: 1109 AEAA 1112
+ AA
Sbjct: 2262 SVAA 2265
Score = 31.2 bits (69), Expect = 5.8
Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)
Query: 330 QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
++ + A L + Q + A KAQ + ++ E R+ EA +++Q
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1394
Query: 390 AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
+ Q L E E Q + AEA + + L + + R L+ + GE+
Sbjct: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454
Query: 440 ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
AL ++ + Q + EA L +QV Q ++ + A R +
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
Query: 489 AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
A L + E+A+R + V+ Q A+ R A + R K ++
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1570
Query: 549 DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
++ AQL + A R + +A + + L+ + + EA+
Sbjct: 1571 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 54.3 bits (129), Expect = 6e-07
Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)
Query: 224 EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
EE ++ V+ + I E ++ L+ +S E ++ EA +R+ I+ ++ +
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
Query: 282 GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
L G A GE QA+R +EA + + A + RR++ + Q
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1501
Query: 337 DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
+L +R + + A +K Q+ Q L+ L + E A R+L +Q+ ++ Q L
Sbjct: 1502 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1554
Query: 397 DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
E E Q + A + A K A+L RSL E ++L + +
Sbjct: 1555 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1603
Query: 457 PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
EA ++ L+ Q K N A+ A+ A E + E+A+R
Sbjct: 1604 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1663
Query: 505 --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
+ V R + + + + +AEG + L A+ ++ +Q L + A
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1723
Query: 561 RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
R + E+ A +L+ L ++A M+ +A +E S S+ + +
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1783
Query: 608 LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
LA A +A + ++ +E AA + ++ AEK AA+G A + E
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1841
Query: 662 ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
+A + R L R L A E ++ +E+ GLV++
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901
Query: 716 AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
+ + ++ A+K +K A ++ ++ + + A R + L A +R++
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961
Query: 772 ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
E+ + REA + K++A +K+ L+ R+ V +
Sbjct: 1962 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Query: 832 REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
R + E + QL+L E A + EEK F Q+
Sbjct: 2008 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2048
Query: 892 EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
+ + Q + QL EA +++ AE V AE +AA +
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2097
Query: 949 YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
E E L + + AAA+ L +EA + +++ AA R AEM +
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2157
Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
+ T R Q +++ +E+ RL E + + Q
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2211
Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
V E + ++ Q++ LS +KA + + D+++ Q L A+ + Q +E R
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2269
Query: 1109 AEAA 1112
+ AA
Sbjct: 2270 SVAA 2273
Score = 31.2 bits (69), Expect = 5.8
Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)
Query: 330 QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
++ + A L + Q + A KAQ + ++ E R+ EA +++Q
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1402
Query: 390 AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
+ Q L E E Q + AEA + + L + + R L+ + GE+
Sbjct: 1403 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1462
Query: 440 ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
AL ++ + Q + EA L +QV Q ++ + A R +
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522
Query: 489 AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
A L + E+A+R + V+ Q A+ R A + R K ++
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1578
Query: 549 DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
++ AQL + A R + +A + + L+ + + EA+
Sbjct: 1579 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1628
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 54.3 bits (129), Expect = 6e-07
Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)
Query: 224 EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
EE ++ V+ + I E ++ L+ +S E ++ EA +R+ I+ ++ +
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485
Query: 282 GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
L G A GE QA+R +EA + + A + RR++ + Q
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1542
Query: 337 DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
+L +R + + A +K Q+ Q L+ L + E A R+L +Q+ ++ Q L
Sbjct: 1543 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1595
Query: 397 DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
E E Q + A + A K A+L RSL E ++L + +
Sbjct: 1596 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1644
Query: 457 PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
EA ++ L+ Q K N A+ A+ A E + E+A+R
Sbjct: 1645 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1704
Query: 505 --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
+ V R + + + + +AEG + L A+ ++ +Q L + A
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1764
Query: 561 RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
R + E+ A +L+ L ++A M+ +A +E S S+ + +
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1824
Query: 608 LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
LA A +A + ++ +E AA + ++ AEK AA+G A + E
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1882
Query: 662 ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
+A + R L R L A E ++ +E+ GLV++
Sbjct: 1883 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942
Query: 716 AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
+ + ++ A+K +K A ++ ++ + + A R + L A +R++
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002
Query: 772 ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
E+ + REA + K++A +K+ L+ R+ V +
Sbjct: 2003 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
Query: 832 REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
R + E + QL+L E A + EEK F Q+
Sbjct: 2049 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2089
Query: 892 EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
+ + Q + QL EA +++ AE V AE +AA +
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2138
Query: 949 YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
E E L + + AAA+ L +EA + +++ AA R AEM +
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2198
Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
+ T R Q +++ +E+ RL E + + Q
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2252
Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
V E + ++ Q++ LS +KA + + D+++ Q L A+ + Q +E R
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2310
Query: 1109 AEAA 1112
+ AA
Sbjct: 2311 SVAA 2314
Score = 31.2 bits (69), Expect = 5.8
Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)
Query: 330 QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
++ + A L + Q + A KAQ + ++ E R+ EA +++Q
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1443
Query: 390 AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
+ Q L E E Q + AEA + + L + + R L+ + GE+
Sbjct: 1444 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1503
Query: 440 ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
AL ++ + Q + EA L +QV Q ++ + A R +
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563
Query: 489 AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
A L + E+A+R + V+ Q A+ R A + R K ++
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1619
Query: 549 DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
++ AQL + A R + +A + + L+ + + EA+
Sbjct: 1620 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669
>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
Length = 1113
Score = 51.6 bits (122), Expect = 4e-06
Identities = 146/794 (18%), Positives = 305/794 (38%), Gaps = 88/794 (11%)
Query: 10 ESILEPVAQQISHLVI-MHEEGEVDGK-------AIPDLTAPVAAVQAAVSNLVRVGKET 61
E +LE + Q+ L ++E E+ K ++ DL + +Q + + +
Sbjct: 77 ERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE 136
Query: 62 VQTTEDQILKRDMPPAFIKVENA-CTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS 120
Q+ ED L+ + ++E A C K ML+ + ++ G+L
Sbjct: 137 SQSQED--LRNQLQNTVHELEAAKCLK----EDMLKDSNTQIEQLRKMMLSHEGVLQEIR 190
Query: 121 DLLLTFDEAEVRKIIRV-CKGILEYLT----VAEVVETMEDLVTYTKN-LGPGMTKMAKM 174
+L+ F+EA +KI L + + +++++ ++ ++Y K + P ++ +
Sbjct: 191 SILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEAL 250
Query: 175 IDERQQELT-----HQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKN 229
E Q ++ HQ+ L++ L S+ + + S+ + I+E +N
Sbjct: 251 KSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARN 310
Query: 230 RNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSA 289
+N + +++ + L+ + TE +++ L +S+L +A+ S
Sbjct: 311 QNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQ 370
Query: 290 SPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVA 349
G+ +Q + + D + EL KE+ + L +T + LR +
Sbjct: 371 ESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSIT--IDHLRRELDNRN--- 425
Query: 350 MQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIR 409
+ Q++ L L ++ + + A K +K+ + L E +++
Sbjct: 426 -MEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQL-------ESTKEML 477
Query: 410 GALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATA 469
+ E ++ + ER IS LT+ L + R + + E L +V
Sbjct: 478 RKVVEELTAKKMTLESSER--------TISDLTTSLQEKERAIEATNAEITKLRSRVDLK 529
Query: 470 LQNLQTKTNRA--VANSRPAKAAVHL-----EGKIEQAQRWIDNPTVDDRGVGQAAIRGL 522
LQ LQ N + N + A+ L + IE ++ I+N T L
Sbjct: 530 LQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMT------------QL 577
Query: 523 VAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKD 582
V + R A M Q L K ++ +L +L + + + R L +++ D L+
Sbjct: 578 VGQHGRTAGAMQVEKAQ--LEK--EINDRRMELKELKILKDKKDAKIRELEARVSD-LEL 632
Query: 583 LKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGA 642
K ++ A ++ + V +LL T+ + N E ++ NF N S ++
Sbjct: 633 EKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEM 692
Query: 643 TAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQW 702
T K + +S +E + ++K+ + A + + T K
Sbjct: 693 TTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQ----------ITAKRGQ 742
Query: 703 IDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM-LVAGATSIARRAN 761
ID ++ ++EA+ + + +K++ K ++ + + +AG + R
Sbjct: 743 IDALQSKIQFLEEAMTN---ANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQE 799
Query: 762 RILLVAKREVENSE 775
R L K +V N E
Sbjct: 800 RRL---KEKVTNME 810
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 50.4 bits (119), Expect = 9e-06
Identities = 123/698 (17%), Positives = 281/698 (40%), Gaps = 109/698 (15%)
Query: 152 ETMEDLVTYTKNLGPGMTKMAKMIDERQQEL--THQEHRVMLVNSMNTVKELLPVLISAM 209
+T++DL + G+ K+ ++++ +L + ++ + + + ++L L +
Sbjct: 1009 QTLDDLQVEEDKVN-GLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQ 1067
Query: 210 KIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEI----------IRVLQ--LTSWDEDA 257
+ + +N K Q IEE LK + F + ++ A+I++ I+ LQ + +E+
Sbjct: 1068 ESIMDLENDKQQ-IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEI 1126
Query: 258 WAS--------KDTEAMKRALASIDSKLNQAKGWL--RDPSASPGDAGEQAIRQILDEAG 307
A K + R L I +L +A G + +A Q +R+ L+EA
Sbjct: 1127 EAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 308 KVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKV 367
E A R++ + LG+ D + ++ Q++ + L ++
Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQIDNLQRVK--------------QKLEKEKSELKMEI 1232
Query: 368 ENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGAL--AEAR---KIAELC 422
++ A +EA++ SK +I + ++ ++ E + Q+ L +AR + EL
Sbjct: 1233 DDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELS 1292
Query: 423 DDPKERDDILRSLGEI-SALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAV 481
+E++ ++ L + ALT +L +L+RQ + ++ A+A + ++ +
Sbjct: 1293 HRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL------ 1346
Query: 482 ANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDL 541
L + E+ Q +A ++ +++ + Y D
Sbjct: 1347 -----------LREQYEEEQE------------AKAELQRALSKANSEVAQWRTKYETDA 1383
Query: 542 LAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFSD 601
+ + + +++ +LA E + A + + SL+ K R+Q EV D+ D
Sbjct: 1384 IQRTEELEEAKKKLAQRLQEAEENTETANSKCA----SLEKTKQRLQ----GEVEDLMRD 1435
Query: 602 TTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGT---ANKSTV 658
+ AT N ++V E + +L A +++ ++ T ++
Sbjct: 1436 LE---RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAY 1492
Query: 659 EGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAID 718
E + ++T R L+ + + ET KN + EK LV++
Sbjct: 1493 EEVVDQLETLRRENKN--------LQEEISDLTEQIAETGKN--LQEAEKTKKLVEQ--- 1539
Query: 719 TKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVE--NSED 776
KS L + E ++ L+ + + +Q ++ + + +R ++ E+E
Sbjct: 1540 EKSDLQVALEEVEGSLEHEESKILRVQLEL-----SQVKSELDRKVIEKDEEIEQLKRNS 1594
Query: 777 PKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQ 814
+ EA+++ D ++ + + K + G++++ +Q
Sbjct: 1595 QRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQ 1632
Score = 37.7 bits (86), Expect = 0.062
Identities = 112/582 (19%), Positives = 207/582 (35%), Gaps = 79/582 (13%)
Query: 173 KMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNF 232
K DE+Q +L H + M + T L + + ++ Q + + L+
Sbjct: 1264 KAKDEQQTQLIHDLN--MQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR 1321
Query: 233 TVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPG 292
+E+ + N + LQ + D D + E + A A + L++A
Sbjct: 1322 QMEEETKAKNAMAHALQSSRHDCDL-LREQYEEEQEAKAELQRALSKANS---------- 1370
Query: 293 DAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQK 352
+ + + D + EL K K L Q Q A+ S +++K
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAK---------KKLAQRL-QEAEENTETANSKCASLEK 1420
Query: 353 AQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLAD-PNGGPEGEEQIRGA 411
+Q QG +VE+ R LE + ++ KK LA+ E + ++ A
Sbjct: 1421 TKQRLQG------EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAA 1474
Query: 412 LAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQ 471
E+R ++ ++ + + +L LRR+ K E L +Q+A +
Sbjct: 1475 QKESRSLST---------ELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGK 1525
Query: 472 NLQ--TKTNRAVANSRP--AKAAVHLEGKIEQAQRWIDNPTVD--------DRGV--GQA 517
NLQ KT + V + A +EG +E + I ++ DR V
Sbjct: 1526 NLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585
Query: 518 AIRGLVAEGHRLANVMMGPYRQDLLAKCDR----------VDQLTAQLADLAARGEGESP 567
I L R A + ++ ++ D ++++ QL +
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQK 1645
Query: 568 QARALASQLQDSL----------KDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPP 617
R + QL+DS +DLK ++ A+ + + + + +K +A+ T
Sbjct: 1646 HLRTVQGQLKDSQLHLDDALRSNEDLKEQL--AIVERRNGLLLEELEEMK-VALEQTERT 1702
Query: 618 DAPNREEVFD--ERAANFENHSGKLGATAEKAAA-VGTANKSTVEGIQASVKTARELTPQ 674
+ +E+ D +R + + L T +K A + IQ S +
Sbjct: 1703 RRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA 1762
Query: 675 VVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEA 716
+ AA + Q H E MK V+ + +DEA
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1804
Score = 32.7 bits (73), Expect = 2.0
Identities = 90/461 (19%), Positives = 176/461 (38%), Gaps = 50/461 (10%)
Query: 149 EVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISA 208
EVV+ +E L KNL ++ + + I E + L E LV K L V +
Sbjct: 1494 EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQ---EKSDLQVALEE 1550
Query: 209 MKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKR 268
++ + + SK ++ L +++ E +E I L+ S + EA++
Sbjct: 1551 VEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNS-------QRAAEALQS 1603
Query: 269 ALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKML 328
L D+++ LR GD E E+ G R++ T K L
Sbjct: 1604 VL---DAEIRSRNDALRLKKKMEGDLNEM-------------EIQLGHSNRQMAETQKHL 1647
Query: 329 GQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKI 388
+ Q+ D Q A++ + + + L ++ + +LE M + + +
Sbjct: 1648 RTVQGQLKD----SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTR 1703
Query: 389 DAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEI--------SA 440
++ L D + + +L +K E D + + ++ S+ E A
Sbjct: 1704 RLSEQELLDASDRVQLLHSQNTSLINTKKKLE-ADIAQCQAEVENSIQESRNAEEKAKKA 1762
Query: 441 LT--SKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIE 498
+T + +A+ ++ + S + K + +++LQ + + A K K+E
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE--AEQLALKGGKKQIQKLE 1820
Query: 499 QAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD---LLAKCDRVDQLTAQL 555
R ++N ++ G A++G + R M +D +L D VD+L A++
Sbjct: 1821 NRVRELENELDVEQKRGAEALKG-AHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKV 1879
Query: 556 ADLAARGEGESPQARALAS---QLQDSLKDLKARMQEAMTQ 593
+ E QA S ++Q L++ R A +Q
Sbjct: 1880 KSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQ 1920
>gi|156938343 talin 2 [Homo sapiens]
Length = 2542
Score = 49.7 bits (117), Expect = 2e-05
Identities = 148/764 (19%), Positives = 266/764 (34%), Gaps = 144/764 (18%)
Query: 165 GPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIE 224
GP + M +QQ + Q HR + P L SA + + T N+ ++
Sbjct: 462 GPETFNVGSMPSPQQQVMVGQMHRGHM-----------PPLTSAQQALMGTINTSMHAVQ 510
Query: 225 EA----------------LKNRNFTVEKMSAEINEI-----------IRVLQLTSWDEDA 257
+A + +R + K+ +EI V+ LT+ D
Sbjct: 511 QAQDDLSELDSLPPLGQDMASRVWVQNKVDESKHEIHSQVDAITAGTASVVNLTAGDP-- 568
Query: 258 WASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGD---AGEQAIRQILDEAGKVGELC- 313
A D A+ A+ +I S L + ++ +A D +GE +R AG V +L
Sbjct: 569 -ADTDYTAVGCAITTISSNLTEMSKGVKLLAALMDDEVGSGEDLLRAARTLAGAVSDLLK 627
Query: 314 -----AGKERREILGTCKMLGQMTDQVADLRARGQGSSP-----VAMQKAQQVSQGLDVL 363
+G+ R+ +L +GQ + + LR G+ + V M A+ V+ +L
Sbjct: 628 AVQPTSGEPRQTVLTAAGSIGQASGDL--LRQIGENETDERFQDVLMSLAKAVANAAAML 685
Query: 364 TAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCD 423
K +N A+ E + IA A + +A A+ ++
Sbjct: 686 VLKAKNVAQVAEDTVLQNRVIAAATQCALS--------------TSQLVACAKVVSPTIS 731
Query: 424 DPKERDDILRSLGEISALTSKLADLRRQGKGDSP---EARALAKQVATALQNLQTKTNRA 480
P ++ ++ + + + DS + A A V+ AL +L +
Sbjct: 732 SPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQVSAAASVVSQALHDLLQHVRQF 791
Query: 481 VANSRPAKAAVHLEGKIEQAQRWIDNPT------VDDRGVGQAAIRGLVAEGHRLANVMM 534
+ P G+ +QA I T + D G R L L N M
Sbjct: 792 ASRGEPI-------GRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSDLVNAMR 844
Query: 535 GPYRQD--------LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKAR 586
+ LLA + TA++ + AA+G +P+ +L+++ + L+
Sbjct: 845 SDAEAEIDMENSKKLLAAAKLLADSTARMVE-AAKGAAANPENEDQQQRLREAAEGLRVA 903
Query: 587 MQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEK 646
A + + L VAA A + + AA + +
Sbjct: 904 TNAAAQNAIKKKI------VNRLEVAAKQAAAAATQTIAASQNAAVSNKNPAAQQQLVQS 957
Query: 647 AAAVGTANKSTVEGIQASVKTARELTPQV----------------VSAARILLRNPGNQA 690
AV V+G++ S A +L+ Q+ VS+A+ + +QA
Sbjct: 958 CKAVADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQA 1017
Query: 691 AYEHF-ETMKNQWIDNVEKMTGL-----------VDEAIDT-----KSLLDASEEAIKKD 733
A + KN E T +D A++T L DA A++
Sbjct: 1018 AAMQLSQCAKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAKMAAVESQ 1077
Query: 734 LDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKT 793
L Q L + + ++ ++L A + E+ RE +A
Sbjct: 1078 LKPLPGETLEKCAQDLGSTSKAVGSSMAQLLTCAAQGNEHYTGVAARETAQA-------- 1129
Query: 794 ISPMVMDAKAVAGNISDPGLQKSFLDSGYRIL-GAVAKVREAFQ 836
+ + A+ VA + +DP + LDS ++ G+ ++EA Q
Sbjct: 1130 LKTLAQAARGVAASTTDPAAAHAMLDSARDVMEGSAMLIQEAKQ 1173
Score = 39.3 bits (90), Expect = 0.021
Identities = 26/94 (27%), Positives = 48/94 (51%)
Query: 748 MLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGN 807
+L++ A ++A A ++L AK + +ED + V AA+ + + + S +V AK V+
Sbjct: 670 VLMSLAKAVANAAAMLVLKAKNVAQVAEDTVLQNRVIAAATQCALSTSQLVACAKVVSPT 729
Query: 808 ISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPD 841
IS P Q+ +++G + +V A Q D
Sbjct: 730 ISSPVCQEQLIEAGKLVDRSVENCVRACQAATTD 763
Score = 38.1 bits (87), Expect = 0.048
Identities = 102/515 (19%), Positives = 179/515 (34%), Gaps = 88/515 (17%)
Query: 404 GEEQIRGALAEARKIAELCD-----DPKERDDILRSLGEISALTSKLADLRRQGKGDSPE 458
GE+ +R A A +++L + R +L + G I + L LR+ G+ ++ E
Sbjct: 608 GEDLLRAARTLAGAVSDLLKAVQPTSGEPRQTVLTAAGSIGQASGDL--LRQIGENETDE 665
Query: 459 ARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQA- 517
Q++ +AVAN AA L K + + ++ + +R + A
Sbjct: 666 R----------FQDVLMSLAKAVAN-----AAAMLVLKAKNVAQVAEDTVLQNRVIAAAT 710
Query: 518 ----AIRGLVAEGHRLANVMMGPYRQDLLAKC----DRVDQLTAQLADLAARGEGESPQA 569
+ LVA ++ + P Q+ L + DR + + A Q
Sbjct: 711 QCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQV 770
Query: 570 RALASQLQDSLKDLKARMQE-------------------AMTQEVSDVFSDTTTPIKLLA 610
A AS + +L DL +++ +T+ + D ++
Sbjct: 771 SAAASVVSQALHDLLQHVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQAR 830
Query: 611 VAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARE 670
V A A D N E + EN L A+ K +
Sbjct: 831 VLAQATSDLVNAMRSDAEAEIDMENSKKLL----------------------AAAKLLAD 868
Query: 671 LTPQVVSAARILLRNPGNQ-------AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLL 723
T ++V AA+ NP N+ A E N N K + + K
Sbjct: 869 STARMVEAAKGAAANPENEDQQQRLREAAEGLRVATNAAAQNAIKKKIVNRLEVAAKQAA 928
Query: 724 DASEEAIKKDLDKCKVAMANIQP---QMLVAGATSIARRANRILLVAKREVENSEDPKFR 780
A+ + I + A++N P Q LV ++A +++ + +ED +
Sbjct: 929 AAATQTIAASQN---AAVSNKNPAAQQQLVQSCKAVADHIPQLVQGVRGSQAQAEDLSAQ 985
Query: 781 EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP 840
A+ +S + S MV AKA +SD + ++A++R A Q
Sbjct: 986 LALIISSQNFLQPGSKMVSSAKAAVPTVSDQAAAMQLSQCAKNLATSLAELRTASQKAHE 1045
Query: 841 DFPPPPPD--LEQLR-LTDELAPPKPPLPEGEVPP 872
P D L ++ L +EL K E ++ P
Sbjct: 1046 ACGPMEIDSALNTVQTLKNELQDAKMAAVESQLKP 1080
Score = 34.7 bits (78), Expect = 0.53
Identities = 76/390 (19%), Positives = 160/390 (41%), Gaps = 58/390 (14%)
Query: 134 IIRVCKGILE--YLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQ--EHRV 189
I++ K ++E L V+ T + L ++ +T++A+++ L E +V
Sbjct: 2020 ILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPETQV 2079
Query: 190 MLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEE-ALKNRNFTVEKMSAEINEIIRVL 248
+L+N++ V + L LISA TK + ++ +++ ++ + M + +++ +
Sbjct: 2080 VLINAIKDVAKALSDLISA------TKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTV 2133
Query: 249 QLTSWDEDAWASKDTEAMKRALASIDSKLN--QAKGWLRDPSASPGDA--GEQAIRQILD 304
+ DE A++ T A++ + I +L Q+K + + ++SP ++ + I
Sbjct: 2134 KAVE-DE---ATRGTRALEATIECIKQELTVFQSKD-VPEKTSSPEESIRMTKGITMATA 2188
Query: 305 EAGKVGELC-----------AGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKA 353
+A G C + K ++L CK D ++R R A++
Sbjct: 2189 KAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTR-------ALRFG 2241
Query: 354 QQVSQG-LDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGAL 412
+ + G LD+L + + + +K++ A L
Sbjct: 2242 TECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQ--------------A 2287
Query: 413 AEARKIAELCD--DPK--ERDDILRSLGEISALTSKLADLRRQGK-GDSPEARALAKQVA 467
AEA K E D DP ++L + I A KL L+ + K + E +Q+
Sbjct: 2288 AEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQIL 2347
Query: 468 TALQNLQTKTNRAVANSRPAKAAVHLEGKI 497
A +++ T+ V ++ A+ + +GK+
Sbjct: 2348 EAAKSIAAATSALVKSASAAQRELVAQGKV 2377
Score = 30.4 bits (67), Expect = 10.0
Identities = 35/157 (22%), Positives = 64/157 (40%), Gaps = 23/157 (14%)
Query: 981 SSKGNDIIAAAKRMALLMAEMSRLVRGGSG--------TKRALIQCAKDIAKASDEVTRL 1032
+S + + AA+ A + +++ +V+ G+ T+ LI KD+AKA ++
Sbjct: 2039 ASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISA 2098
Query: 1033 AKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLV 1092
K A + D L + + T T L L TVKA ++E+ + T L
Sbjct: 2099 TKGAASKPVDDPSMYQLKGAAKVMVTNVTSL--LKTVKAV--------EDEATRGTRALE 2148
Query: 1093 HNAQNLMQSV-----KETVREAEAASIKIRTDAGFTL 1124
+ + Q + K+ + + IR G T+
Sbjct: 2149 ATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITM 2185
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 48.1 bits (113), Expect = 5e-05
Identities = 111/622 (17%), Positives = 246/622 (39%), Gaps = 90/622 (14%)
Query: 59 KETVQTTEDQI-LKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILS 117
KE + ED+ + ++ K+E+ C++L + L+ V + + +
Sbjct: 926 KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK---VK 982
Query: 118 GTSDLLLTFDEAEVRKIIRVCKGILE-YLTVAEVVETMEDLVTYTKNLGPGMTKMAKMID 176
++ + DE + K+ + K + E + + ++ ED V L K+ + +D
Sbjct: 983 NLTEEMAGLDET-IAKLTKEKKALQEAHQQTLDDLQAEEDKVN---TLTKAKIKLEQQVD 1038
Query: 177 ERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEK 236
+ + L ++ + + ++ ++L L A + + +N K Q ++E LK + F +
Sbjct: 1039 DLEGSL--EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ-LDEKLKKKEFEISN 1095
Query: 237 MSAEINEI----------IRVLQ--LTSWDED--------AWASKDTEAMKRALASIDSK 276
+ ++I + I+ LQ + +E+ A A K + R L I +
Sbjct: 1096 LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1155
Query: 277 LNQAKGWL--RDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQ 334
L +A G + +A Q +R+ L+EA E A R++ + LG+ D
Sbjct: 1156 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215
Query: 335 VADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNW 394
+ ++ Q++ + + ++++ A +E ++ +K ++ K ++
Sbjct: 1216 LQRVK--------------QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261
Query: 395 LADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKG 454
L++ E ++++ L R + E + R L E AL S+L+ +GK
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQ-----TESGEFSRQLDEKEALVSQLS----RGK- 1311
Query: 455 DSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVH----LEGKIEQAQRWIDNPTVD 510
+A +Q+ + L+ + A + +++ H L + E+ Q
Sbjct: 1312 -----QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE-------- 1358
Query: 511 DRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQAR 570
+A ++ +++ + Y D + + + +++ +LA E
Sbjct: 1359 ----SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 571 ALASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERA 630
A + SL+ K R+Q EV D+ D + A A N +++ E
Sbjct: 1415 AKCA----SLEKTKQRLQ----NEVEDLMLDVE---RTNAACAALDKKQRNFDKILAEWK 1463
Query: 631 ANFENHSGKLGATAEKAAAVGT 652
E +L A+ ++A ++GT
Sbjct: 1464 QKCEETHAELEASQKEARSLGT 1485
Score = 35.4 bits (80), Expect = 0.31
Identities = 62/297 (20%), Positives = 128/297 (43%), Gaps = 29/297 (9%)
Query: 308 KVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKV 367
K+ L E + + T K + ++ D A+ + +K + + + L +V
Sbjct: 841 KIKPLLKSAETEKEMATMK---EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 897
Query: 368 ENAARKL-EAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGAL-AEARKIAELCDD- 424
+ A L +A Q I KI + + E EE+I L A+ RK+ + C +
Sbjct: 898 QAEAEGLADAEERCDQLIKTKIQLEAK-IKEVTERAEDEEEINAELTAKKRKLEDECSEL 956
Query: 425 PKERDDILRSLGEISA-----------LTSKLADLRRQGKGDSPEARALAKQVATALQNL 473
K+ DD+ +L ++ LT ++A L + E +AL + L +L
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 474 QTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGH-RLANV 532
Q + ++ + KA + LE +++ + ++ + +A + EG +LA
Sbjct: 1017 QAEEDKV---NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK---LEGDLKLAQE 1070
Query: 533 MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQE 589
+ + +++ + ++++L ++ E E +AL QLQ +K+L+AR++E
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE----QALGIQLQKKIKELQARIEE 1123
Score = 34.7 bits (78), Expect = 0.53
Identities = 80/437 (18%), Positives = 155/437 (35%), Gaps = 79/437 (18%)
Query: 426 KERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSR 485
K +D++ +S + L K+ L ++ + +A A+ +A A + +
Sbjct: 864 KIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD----------Q 913
Query: 486 PAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDL---- 541
K + LE KI++ V +R + I + R ++D+
Sbjct: 914 LIKTKIQLEAKIKE---------VTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964
Query: 542 --LAKCDR--------VDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
LAK ++ V LT ++A L + + +AL Q +L DL+A +
Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024
Query: 592 T---------QEVSDVFSDTTTPIKL--------------LAVAATAPPDAPNREEVFDE 628
T Q+V D+ KL L +A + D N ++ DE
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 629 RAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGN 688
+ E L + E A+G + ++ +QA ++ E + A+R +
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE-EIEAERASRAKAEKQRS 1143
Query: 689 QAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM 748
+ E E + +E+ G I+ +A + +++DL++ + +
Sbjct: 1144 DLSRELEEIS-----ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1198
Query: 749 LVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNI 808
A S+A +I + ++ +L K S M M+ +A N+
Sbjct: 1199 RKKHADSVAELGEQI-----------------DNLQRVKQKLEKEKSEMKMEIDDLASNV 1241
Query: 809 SDPGLQKSFLDSGYRIL 825
K L+ R L
Sbjct: 1242 ETVSKAKGNLEKMCRTL 1258
Score = 34.3 bits (77), Expect = 0.69
Identities = 54/254 (21%), Positives = 98/254 (38%), Gaps = 45/254 (17%)
Query: 224 EEALKNRNFTVEK----MSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALA-------- 271
+E LK + VE+ + AEI E+ L+ T + +A +R
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1729
Query: 272 -----SIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCK 326
+++ ++Q +G + D +A E+A + I D A EL KE+ +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEEL--KKEQDTSAHLER 1787
Query: 327 MLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAA--------------- 371
M M V DL+ R + +A++ ++ Q L+ ++E
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847
Query: 372 ---RKLEAMTNSKQSIAKKIDAAQNWL--------ADPNGGPEGEEQIRGALAEARKIAE 420
R+++ +T + K I Q+ + + E EEQ LA+ RK+
Sbjct: 1848 KHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQH 1907
Query: 421 LCDDPKERDDILRS 434
++ +ER DI S
Sbjct: 1908 ELEEAEERADIAES 1921
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 48.1 bits (113), Expect = 5e-05
Identities = 111/622 (17%), Positives = 246/622 (39%), Gaps = 90/622 (14%)
Query: 59 KETVQTTEDQI-LKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILS 117
KE + ED+ + ++ K+E+ C++L + L+ V + + +
Sbjct: 926 KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK---VK 982
Query: 118 GTSDLLLTFDEAEVRKIIRVCKGILE-YLTVAEVVETMEDLVTYTKNLGPGMTKMAKMID 176
++ + DE + K+ + K + E + + ++ ED V L K+ + +D
Sbjct: 983 NLTEEMAGLDET-IAKLTKEKKALQEAHQQTLDDLQAEEDKVN---TLTKAKIKLEQQVD 1038
Query: 177 ERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEK 236
+ + L ++ + + ++ ++L L A + + +N K Q ++E LK + F +
Sbjct: 1039 DLEGSL--EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ-LDEKLKKKEFEISN 1095
Query: 237 MSAEINEI----------IRVLQ--LTSWDED--------AWASKDTEAMKRALASIDSK 276
+ ++I + I+ LQ + +E+ A A K + R L I +
Sbjct: 1096 LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1155
Query: 277 LNQAKGWL--RDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQ 334
L +A G + +A Q +R+ L+EA E A R++ + LG+ D
Sbjct: 1156 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215
Query: 335 VADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNW 394
+ ++ Q++ + + ++++ A +E ++ +K ++ K ++
Sbjct: 1216 LQRVK--------------QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261
Query: 395 LADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKG 454
L++ E ++++ L R + E + R L E AL S+L+ +GK
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQ-----TESGEFSRQLDEKEALVSQLS----RGK- 1311
Query: 455 DSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVH----LEGKIEQAQRWIDNPTVD 510
+A +Q+ + L+ + A + +++ H L + E+ Q
Sbjct: 1312 -----QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE-------- 1358
Query: 511 DRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQAR 570
+A ++ +++ + Y D + + + +++ +LA E
Sbjct: 1359 ----SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 571 ALASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERA 630
A + SL+ K R+Q EV D+ D + A A N +++ E
Sbjct: 1415 AKCA----SLEKTKQRLQ----NEVEDLMLDVE---RTNAACAALDKKQRNFDKILAEWK 1463
Query: 631 ANFENHSGKLGATAEKAAAVGT 652
E +L A+ ++A ++GT
Sbjct: 1464 QKCEETHAELEASQKEARSLGT 1485
Score = 35.4 bits (80), Expect = 0.31
Identities = 62/297 (20%), Positives = 128/297 (43%), Gaps = 29/297 (9%)
Query: 308 KVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKV 367
K+ L E + + T K + ++ D A+ + +K + + + L +V
Sbjct: 841 KIKPLLKSAETEKEMATMK---EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 897
Query: 368 ENAARKL-EAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGAL-AEARKIAELCDD- 424
+ A L +A Q I KI + + E EE+I L A+ RK+ + C +
Sbjct: 898 QAEAEGLADAEERCDQLIKTKIQLEAK-IKEVTERAEDEEEINAELTAKKRKLEDECSEL 956
Query: 425 PKERDDILRSLGEISA-----------LTSKLADLRRQGKGDSPEARALAKQVATALQNL 473
K+ DD+ +L ++ LT ++A L + E +AL + L +L
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 474 QTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGH-RLANV 532
Q + ++ + KA + LE +++ + ++ + +A + EG +LA
Sbjct: 1017 QAEEDKV---NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK---LEGDLKLAQE 1070
Query: 533 MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQE 589
+ + +++ + ++++L ++ E E +AL QLQ +K+L+AR++E
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE----QALGIQLQKKIKELQARIEE 1123
Score = 34.7 bits (78), Expect = 0.53
Identities = 80/437 (18%), Positives = 155/437 (35%), Gaps = 79/437 (18%)
Query: 426 KERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSR 485
K +D++ +S + L K+ L ++ + +A A+ +A A + +
Sbjct: 864 KIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD----------Q 913
Query: 486 PAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDL---- 541
K + LE KI++ V +R + I + R ++D+
Sbjct: 914 LIKTKIQLEAKIKE---------VTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964
Query: 542 --LAKCDR--------VDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
LAK ++ V LT ++A L + + +AL Q +L DL+A +
Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024
Query: 592 T---------QEVSDVFSDTTTPIKL--------------LAVAATAPPDAPNREEVFDE 628
T Q+V D+ KL L +A + D N ++ DE
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 629 RAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGN 688
+ E L + E A+G + ++ +QA ++ E + A+R +
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE-EIEAERASRAKAEKQRS 1143
Query: 689 QAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM 748
+ E E + +E+ G I+ +A + +++DL++ + +
Sbjct: 1144 DLSRELEEIS-----ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1198
Query: 749 LVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNI 808
A S+A +I + ++ +L K S M M+ +A N+
Sbjct: 1199 RKKHADSVAELGEQI-----------------DNLQRVKQKLEKEKSEMKMEIDDLASNV 1241
Query: 809 SDPGLQKSFLDSGYRIL 825
K L+ R L
Sbjct: 1242 ETVSKAKGNLEKMCRTL 1258
Score = 34.3 bits (77), Expect = 0.69
Identities = 54/254 (21%), Positives = 98/254 (38%), Gaps = 45/254 (17%)
Query: 224 EEALKNRNFTVEK----MSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALA-------- 271
+E LK + VE+ + AEI E+ L+ T + +A +R
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1729
Query: 272 -----SIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCK 326
+++ ++Q +G + D +A E+A + I D A EL KE+ +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEEL--KKEQDTSAHLER 1787
Query: 327 MLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAA--------------- 371
M M V DL+ R + +A++ ++ Q L+ ++E
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847
Query: 372 ---RKLEAMTNSKQSIAKKIDAAQNWL--------ADPNGGPEGEEQIRGALAEARKIAE 420
R+++ +T + K I Q+ + + E EEQ LA+ RK+
Sbjct: 1848 KHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQH 1907
Query: 421 LCDDPKERDDILRS 434
++ +ER DI S
Sbjct: 1908 ELEEAEERADIAES 1921
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 47.8 bits (112), Expect = 6e-05
Identities = 144/748 (19%), Positives = 279/748 (37%), Gaps = 95/748 (12%)
Query: 143 EYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLV---------- 192
E T E+ + L T +L + ++ IDE + +L +E +
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1105
Query: 193 --NSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQL 250
N++ V+EL + + F + K S+N+ A K + E++ A E+ L
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESEKASRNK----AEKQKRDLSEELEALKTELEDTLDT 1161
Query: 251 TSWDEDAWASKDTEA--MKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGK 308
T+ ++ ++ E +K+AL ++K ++A+ ++D A E+ Q+
Sbjct: 1162 TAAQQELRTKREQEVAELKKALEE-ETKNHEAQ--IQDMRQRHATALEELSEQLEQAKRF 1218
Query: 309 VGELCAGKE-----RREILGTCKMLGQ-----------MTDQVADLRAR---GQGSSPVA 349
L K+ +E+ K+L Q + QV +L A+ G
Sbjct: 1219 KANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVEL 1278
Query: 350 MQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEG-EEQI 408
+KA ++ LD ++ +E A +K S+ ++ Q L + +I
Sbjct: 1279 AEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRI 1338
Query: 409 RGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVAT 468
R E + E ++ +E L ++ AL S+LAD +++ D +L +
Sbjct: 1339 RQLEEEKNSLQEQQEEEEEARKNLEK--QVLALQSQLADTKKKVDDDLGTIESLEEAKKK 1396
Query: 469 ALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHR 528
L++ + + R A A LE + Q+ +D+ TVD Q A
Sbjct: 1397 LLKDAEALSQRL---EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVA---------- 1443
Query: 529 LANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQ 588
+L K + DQL A+ ++AR E +A A A + + L ++
Sbjct: 1444 ----------SNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 589 EAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNR------------EEVFDERAANFENH 636
EA+ E + F ++ + D + E+ +E E
Sbjct: 1494 EAL--EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 637 SGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGN-QAAYEHF 695
+L AT + + ++ + ++T E Q R+L++ +A E
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE---QNEEKKRLLIKQVRELEAELEDE 1608
Query: 696 ETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATS 755
+ + + +KM ID K L+A EA K D+ + +Q QM
Sbjct: 1609 RKQRALAVASKKKM------EIDLKD-LEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661
Query: 756 IARRANRILLVAKREVENSEDPKFREAVKAASDELS---KTISPMVMDAKAVAGNISDPG 812
RA+R + A+ + + + +EL+ + + +A I++
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 813 LQKS-FLDSGYRILGAVAKVREAFQPQE 839
KS LD R+ +A++ E + ++
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Score = 35.4 bits (80), Expect = 0.31
Identities = 66/310 (21%), Positives = 127/310 (40%), Gaps = 40/310 (12%)
Query: 316 KERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLE 375
++ +++L +L + +L A + K Q++ + L L ++VE + +
Sbjct: 880 RKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQ 939
Query: 376 AMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDD-PKERDDILRS 434
+ N K+ + I + L D G + Q+ AEA KI ++ ++ D +
Sbjct: 940 ILQNEKKKMQAHIQDLEEQL-DEEEGARQKLQLEKVTAEA-KIKKMEEEILLLEDQNSKF 997
Query: 435 LGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVAN-SRPAKAAVHL 493
+ E + ++A+ Q + +A+ LAK ++ K +++ K
Sbjct: 998 IKEKKLMEDRIAECSSQLAEEEEKAKNLAK--------IRNKQEVMISDLEERLKKEEKT 1049
Query: 494 EGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDR------ 547
++E+A+R +D T D + Q A + +L Q LA+ D
Sbjct: 1050 RQELEKAKRKLDGETTDLQ--DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 548 -----VDQLTAQLADL--------AARGEGE------SPQARALASQLQDSLKDLKARMQ 588
V +L AQ+A+L A+R + E S + AL ++L+D+L D A Q
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL-DTTAAQQ 1166
Query: 589 EAMTQEVSDV 598
E T+ +V
Sbjct: 1167 ELRTKREQEV 1176
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 47.8 bits (112), Expect = 6e-05
Identities = 56/229 (24%), Positives = 90/229 (39%), Gaps = 46/229 (20%)
Query: 690 AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEA------IKKDLDKCKVAMAN 743
A E ET KN ++++E++ V A+ T+ L DA E+ ++K L + + +
Sbjct: 386 ALLEDTET-KNAVLEHMEELQEQV--ALLTERLRDAENESMAKIAELEKQLSQARKELET 442
Query: 744 IQPQMLVAGATSIARR----------ANRILLVAKREVENSEDPKFREAVKAASDELSKT 793
++ + + A +RR A + +VE E+ ++ D +S
Sbjct: 443 LRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIE 502
Query: 794 ISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLR 853
I P+ + A G+ PG+ + A +P PPPPP L L
Sbjct: 503 ILPVAV-ATPSGGDAPTPGVPTG---------SPSPDLAPAAEPAPGAAPPPPPPLPGLP 552
Query: 854 LTDEL----------------APPKPPLPEGEVPPPRPPPPEEKDEEFP 886
E PP PPLP G++PPP PPPP + P
Sbjct: 553 SPQEAPPSAPPQAPPLPGSPEPPPAPPLP-GDLPPPPPPPPPPPGTDGP 600
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/47 (46%), Positives = 25/47 (53%), Gaps = 11/47 (23%)
Query: 837 PQEPDFPPPPPDLEQLRLTDELAPPKPPLP-----EGEVPPPRPPPP 878
P P+ PP PP L +L PP PP P +G VPPP PPPP
Sbjct: 569 PGSPEPPPAPP------LPGDLPPPPPPPPPPPGTDGPVPPPPPPPP 609
Score = 30.8 bits (68), Expect = 7.6
Identities = 31/115 (26%), Positives = 44/115 (38%), Gaps = 8/115 (6%)
Query: 859 APPKPPLPEGEVP--PPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSS-- 914
A +PP PE P P RP E K EE E+ ++ P + ++ A S
Sbjct: 455 ASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGG 514
Query: 915 ---KPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQPVNQPI 966
PG+P + A+ A A P PP + P+ PS P P+
Sbjct: 515 DAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQ-EAPPSAPPQAPPL 568
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 47.8 bits (112), Expect = 6e-05
Identities = 88/409 (21%), Positives = 159/409 (38%), Gaps = 63/409 (15%)
Query: 235 EKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDA 294
EK+ E+ IR L+ + A+ + EA + +++ + + +R+ S
Sbjct: 719 EKLQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASG 778
Query: 295 G------------EQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARG 342
G EQA + D ++ EL E C + + +A+ ARG
Sbjct: 779 GGGGDTTQLRAALEQAREDLRDRDSRLREL-------EAASACLDEARASRLLAEEEARG 831
Query: 343 QGSSPVAMQKAQ-QVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGG 401
+ ++A+ + S+ L+VL ++ A E + + + DAA+ +A+
Sbjct: 832 LRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAEL--- 888
Query: 402 PEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARA 461
P E+ R LAE R+ +E R ++ + E L + +LR + E A
Sbjct: 889 PAACEEARQGLAELREASEAL-----RQSVVPA-SEHRRLQEEALELRGRAASLEQEVVA 942
Query: 462 LAKQVATALQNLQTKTNRAVANSRPAKAA-------VHLEGKIEQAQRWIDNPTVD---- 510
K+ A L+ + +VA S + LEG++E+ R + + +
Sbjct: 943 TGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
Query: 511 ---------DRGVGQAAI-------RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQ 554
+R +A + RGL E R Q+ L K D+ +
Sbjct: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRA--QEALDKAKEKDKKITE 1060
Query: 555 LA-DLAARGEGESPQARALASQ----LQDSLKDLKARMQEAMTQEVSDV 598
L+ ++ E Q ALA+ L+D +KDL+ ++QEA S V
Sbjct: 1061 LSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVV 1109
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 47.4 bits (111), Expect = 8e-05
Identities = 83/390 (21%), Positives = 158/390 (40%), Gaps = 48/390 (12%)
Query: 154 MEDLVTYTKNLGPGMTKMAKM---IDERQQEL-THQEHRVMLVNSMNTVKELLPVLISAM 209
MEDL++ ++G + ++ K ++++ +E+ T E + + K L V + AM
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 210 KI-FVTTKNSKNQGIEEALKNRNFTVEKMSAEINE----------IIRVLQLTSWDEDAW 258
K F +++ EE K V +M AE+ + + L++ D +A
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Query: 259 ---ASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDA------GEQAIRQILDEAGKV 309
A+K+ + + L + +++ L D AS + E+ ++ + E ++
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685
Query: 310 GELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVEN 369
E A ER + + Q D++AD A G +A+++ +++ + L ++E
Sbjct: 1686 QEELAAAERAK-----RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE 1740
Query: 370 AARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERD 429
E + + + +ID L + E R L K EL +E +
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK--ELKVKLQEME 1798
Query: 430 DILRSL--GEISALTSKLADLRRQGKGDSPEARALAKQVATALQNL-------------- 473
++S I+AL +K+A L Q ++ E +A KQV + L
Sbjct: 1799 GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNA 1858
Query: 474 -QTKTNRAVANSRPAKAAVHLEGKIEQAQR 502
Q K A++R + LE E+AQR
Sbjct: 1859 EQYKDQADKASTRLKQLKRQLEEAEEEAQR 1888
Score = 43.5 bits (101), Expect = 0.001
Identities = 119/598 (19%), Positives = 234/598 (39%), Gaps = 82/598 (13%)
Query: 227 LKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRD 286
LK RN+ ++ ++ +++V S E+ +K+ E +K + K A+ L +
Sbjct: 820 LKLRNWQWWRLFTKVKPLLQV----SRQEEEMMAKEEELVK-----VREKQLAAENRLTE 870
Query: 287 PSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSS 346
+ + Q+ ++ ELCA E T K ++ + DL AR +
Sbjct: 871 METLQSQLMAEKL-QLQEQLQAETELCAEAEELRARLTAKKQ-ELEEICHDLEARVEEEE 928
Query: 347 P------VAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNG 400
+K QQ Q L+ + E+A +KL+ + ++ KK++ Q L D N
Sbjct: 929 ERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC 988
Query: 401 GPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEI-SALTSKLADLRRQGKGDSPEA 459
E++ L E R IAE + E ++ +SL ++ + + + DL + + + +
Sbjct: 989 KLAKEKK----LLEDR-IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQR 1043
Query: 460 RALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAI 519
+ L K L+ T + +A + A E K++ A++ + R +AA
Sbjct: 1044 QELEK-TRRKLEGDSTDLSDQIAELQAQIA----ELKMQLAKKEEELQAALARVEEEAAQ 1098
Query: 520 RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDS 579
+ + + R + ++DL ++ ++ Q DL GE + AL ++L+D+
Sbjct: 1099 KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL---GE----ELEALKTELEDT 1151
Query: 580 LKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGK 639
L D A QE ++ +V + T +A E E + HS
Sbjct: 1152 L-DSTAAQQELRSKREQEV----------NILKKTLEEEAKTHEAQIQEMR---QKHSQA 1197
Query: 640 LGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGN----------- 688
+ AE+ K ++ + +T ++ + ++LL+ G+
Sbjct: 1198 VEELAEQL----EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253
Query: 689 ----QAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANI 744
Q + E ++ + D V K+ +D S D+ + KD + + +
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDT 1313
Query: 745 QPQMLVAGATSIARRANRILLVAKREVENSEDPK--FREAV---KAASDELSKTISPM 797
Q + + NR L +++ ED K FRE + + A L K I+ +
Sbjct: 1314 Q---------ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Score = 38.5 bits (88), Expect = 0.037
Identities = 90/454 (19%), Positives = 187/454 (41%), Gaps = 67/454 (14%)
Query: 170 KMAKMIDERQQELTHQEHRVMLVN-SMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALK 228
++AK +E Q L E N ++ ++EL + + + + S+N+ A K
Sbjct: 1077 QLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNK----AEK 1132
Query: 229 NRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEA--MKRALASIDSKLNQAKGWLRD 286
+ E++ A E+ L T+ ++ + ++ E +K+ L ++K ++A+ +++
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE-EAKTHEAQ--IQE 1189
Query: 287 PSASPGDAGEQAIRQILDEAGKVGELCAGK-----ERREILGTCKMLGQ----------- 330
A E+ Q+ L K ER E+ K+L Q
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 331 MTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDA 390
+ Q+ +L+ + V + A +V++ L +++N L + + K A
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTK----LQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 391 AQNWLADPNGGPEGEEQIRGALAEARKIAELCDDP-------KERDDILRSLG-EISALT 442
++ L D +E+ R L+ + K+ ++ D+ +E ++ +L +I+ L
Sbjct: 1306 LESQLQDTQ--ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363
Query: 443 SKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVH--LEGKIEQA 500
+++AD++++ + DS A++V LQ K ++ K A + LE +
Sbjct: 1364 AQVADMKKKME-DSVGCLETAEEVKRKLQ----KDLEGLSQRHEEKVAAYDKLEKTKTRL 1418
Query: 501 QRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
Q+ +D+ VD Q+A +L K + DQL A+ ++A
Sbjct: 1419 QQELDDLLVDLDHQRQSAC--------------------NLEKKQKKFDQLLAEEKTISA 1458
Query: 561 RGEGESPQARALASQLQDSLKDLKARMQEAMTQE 594
+ E +A A A + + L ++EAM Q+
Sbjct: 1459 KYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 47.0 bits (110), Expect = 1e-04
Identities = 120/545 (22%), Positives = 210/545 (38%), Gaps = 107/545 (19%)
Query: 149 EVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISA 208
EV++ +E V Y +N G+ + A + Q L HQ A
Sbjct: 3497 EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQ-LLHQAE-------------------VA 3536
Query: 209 MKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDED----AWASKDTE 264
+ F+ K N G ++N+ + + + E+ QL D++ +DT+
Sbjct: 3537 QQEFLEVKQRVNSGCV-MMENKLEGIGQFHCRVREMFS--QLADLDDELDGMGAIGRDTD 3593
Query: 265 AMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGT 324
+++ + + LN+ D AS E R +L+E G + ++LG
Sbjct: 3594 SLQSQIEDVRLFLNKIHVLKLDIEAS-----EAECRHMLEEEGTL----------DLLGL 3638
Query: 325 CKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSI 384
+ L + Q L RG KA+Q + L++ +VE+ RKL+ + N +
Sbjct: 3639 KRELEALNKQCGKLTERG---------KARQ--EQLELTLGRVEDFYRKLKGL-NDATTA 3686
Query: 385 AKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERD-DILRSLGEISALTS 443
A++ +A Q W+ G E E I LA+ + + DP + + LG+ + S
Sbjct: 3687 AEEAEALQ-WVV----GTE-VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ-GLIQS 3739
Query: 444 KLADLRRQG-KGDSPEARA----LAKQVATALQNLQ--------------------TKTN 478
D QG + D E A L K+VA + LQ T
Sbjct: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
Query: 479 RAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYR 538
+AN +P A + Q Q+ + +DDR +A + L AEG R+A
Sbjct: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQR-LLDDR---KATVDMLQAEGGRIAQ------- 3848
Query: 539 QDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDV 598
A+ +++T QL L +R +A A QL+D L + A+ + +SD
Sbjct: 3849 ---SAELADREKITGQLESLESRWTELLSKAAARQKQLEDIL--VLAKQFHETAEPISDF 3903
Query: 599 FSDTTTPIKLLAVAATAPPDAPNREEVFDERA--ANFENHSGKLGATAEKAAAVGTANKS 656
S T KL A ++++ +A + ENH+ + + ++ +
Sbjct: 3904 LS--VTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSP 3961
Query: 657 TVEGI 661
+G+
Sbjct: 3962 AEQGV 3966
Score = 33.1 bits (74), Expect = 1.5
Identities = 53/245 (21%), Positives = 99/245 (40%), Gaps = 51/245 (20%)
Query: 354 QQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADP-----NGGPEGEEQ- 407
++++ + L KV +L+ ++ +WLAD N P E
Sbjct: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYK 3813
Query: 408 -IRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRR-QGKGDSPEAR----- 460
++ + E + + L DD K D+L++ G A +++LAD + G+ +S E+R
Sbjct: 3814 VVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELL 3873
Query: 461 --------------ALAKQ---VATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQ---- 499
LAKQ A + + + T + +ANS P KI+Q
Sbjct: 3874 SKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQT---AKIQQQIIR 3930
Query: 500 ---AQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLA 556
+ I+N D + V G L++ + P Q +L+ +++D L A+ +
Sbjct: 3931 HKALEEDIENHATD--------VHQAVKIGQSLSS-LTSPAEQGVLS--EKIDSLQARYS 3979
Query: 557 DLAAR 561
++ R
Sbjct: 3980 EIQDR 3984
Score = 32.3 bits (72), Expect = 2.6
Identities = 80/400 (20%), Positives = 153/400 (38%), Gaps = 79/400 (19%)
Query: 18 QQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPA 77
+Q+ ++++ ++ + I D ++ + ++N VG +T + + I + +
Sbjct: 3881 KQLEDILVLAKQFHETAEPISDF---LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEE- 3936
Query: 78 FIKVENACTKLVQAAQMLQS-DPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIR 136
+EN T + QA ++ QS + PA +G+LS D L +A +I
Sbjct: 3937 --DIENHATDVHQAVKIGQSLSSLTSPAE-------QGVLSEKIDSL----QARYSEIQD 3983
Query: 137 VC--KGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKM-IDERQQELTHQEHRVMLVN 193
C K L ++ ED V L K++ + + + +Q++ H++H L
Sbjct: 3984 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 4043
Query: 194 SMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE----INEIIRVLQ 249
+ V ++ + +++A+KN +++ + E I E + ++
Sbjct: 4044 NEEIV-------------------NRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIK 4084
Query: 250 LTSWDEDAWASKDTEAMKRA---LASIDSKLNQAKGWLRD------PSASPGDAGEQAI- 299
D +SK +++A S + GWLR+ S GEQ
Sbjct: 4085 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQ 4144
Query: 300 ---------------RQILDEAGKVG----ELCAGKERREILGTCKMLGQMTDQ---VAD 337
R +LD +V EL + R G K++ +Q V+D
Sbjct: 4145 FQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVSD 4201
Query: 338 LRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAM 377
+ A+Q++QQ Q D A V RKL A+
Sbjct: 4202 TIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 47.0 bits (110), Expect = 1e-04
Identities = 120/545 (22%), Positives = 210/545 (38%), Gaps = 107/545 (19%)
Query: 149 EVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISA 208
EV++ +E V Y +N G+ + A + Q L HQ A
Sbjct: 2995 EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQ-LLHQAE-------------------VA 3034
Query: 209 MKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDED----AWASKDTE 264
+ F+ K N G ++N+ + + + E+ QL D++ +DT+
Sbjct: 3035 QQEFLEVKQRVNSGCV-MMENKLEGIGQFHCRVREMFS--QLADLDDELDGMGAIGRDTD 3091
Query: 265 AMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGT 324
+++ + + LN+ D AS E R +L+E G + ++LG
Sbjct: 3092 SLQSQIEDVRLFLNKIHVLKLDIEAS-----EAECRHMLEEEGTL----------DLLGL 3136
Query: 325 CKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSI 384
+ L + Q L RG KA+Q + L++ +VE+ RKL+ + N +
Sbjct: 3137 KRELEALNKQCGKLTERG---------KARQ--EQLELTLGRVEDFYRKLKGL-NDATTA 3184
Query: 385 AKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERD-DILRSLGEISALTS 443
A++ +A Q W+ G E E I LA+ + + DP + + LG+ + S
Sbjct: 3185 AEEAEALQ-WVV----GTE-VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ-GLIQS 3237
Query: 444 KLADLRRQG-KGDSPEARA----LAKQVATALQNLQ--------------------TKTN 478
D QG + D E A L K+VA + LQ T
Sbjct: 3238 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3297
Query: 479 RAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYR 538
+AN +P A + Q Q+ + +DDR +A + L AEG R+A
Sbjct: 3298 ELIANQKPPSAEYKVVKAQIQEQKLLQR-LLDDR---KATVDMLQAEGGRIAQ------- 3346
Query: 539 QDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDV 598
A+ +++T QL L +R +A A QL+D L + A+ + +SD
Sbjct: 3347 ---SAELADREKITGQLESLESRWTELLSKAAARQKQLEDIL--VLAKQFHETAEPISDF 3401
Query: 599 FSDTTTPIKLLAVAATAPPDAPNREEVFDERA--ANFENHSGKLGATAEKAAAVGTANKS 656
S T KL A ++++ +A + ENH+ + + ++ +
Sbjct: 3402 LS--VTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSP 3459
Query: 657 TVEGI 661
+G+
Sbjct: 3460 AEQGV 3464
Score = 33.1 bits (74), Expect = 1.5
Identities = 53/245 (21%), Positives = 99/245 (40%), Gaps = 51/245 (20%)
Query: 354 QQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADP-----NGGPEGEEQ- 407
++++ + L KV +L+ ++ +WLAD N P E
Sbjct: 3252 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYK 3311
Query: 408 -IRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRR-QGKGDSPEAR----- 460
++ + E + + L DD K D+L++ G A +++LAD + G+ +S E+R
Sbjct: 3312 VVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELL 3371
Query: 461 --------------ALAKQ---VATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQ---- 499
LAKQ A + + + T + +ANS P KI+Q
Sbjct: 3372 SKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQT---AKIQQQIIR 3428
Query: 500 ---AQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLA 556
+ I+N D + V G L++ + P Q +L+ +++D L A+ +
Sbjct: 3429 HKALEEDIENHATD--------VHQAVKIGQSLSS-LTSPAEQGVLS--EKIDSLQARYS 3477
Query: 557 DLAAR 561
++ R
Sbjct: 3478 EIQDR 3482
Score = 32.3 bits (72), Expect = 2.6
Identities = 80/400 (20%), Positives = 153/400 (38%), Gaps = 79/400 (19%)
Query: 18 QQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPA 77
+Q+ ++++ ++ + I D ++ + ++N VG +T + + I + +
Sbjct: 3379 KQLEDILVLAKQFHETAEPISDF---LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEE- 3434
Query: 78 FIKVENACTKLVQAAQMLQS-DPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIR 136
+EN T + QA ++ QS + PA +G+LS D L +A +I
Sbjct: 3435 --DIENHATDVHQAVKIGQSLSSLTSPAE-------QGVLSEKIDSL----QARYSEIQD 3481
Query: 137 VC--KGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKM-IDERQQELTHQEHRVMLVN 193
C K L ++ ED V L K++ + + + +Q++ H++H L
Sbjct: 3482 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 3541
Query: 194 SMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE----INEIIRVLQ 249
+ V ++ + +++A+KN +++ + E I E + ++
Sbjct: 3542 NEEIV-------------------NRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIK 3582
Query: 250 LTSWDEDAWASKDTEAMKRA---LASIDSKLNQAKGWLRD------PSASPGDAGEQAI- 299
D +SK +++A S + GWLR+ S GEQ
Sbjct: 3583 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQ 3642
Query: 300 ---------------RQILDEAGKVG----ELCAGKERREILGTCKMLGQMTDQ---VAD 337
R +LD +V EL + R G K++ +Q V+D
Sbjct: 3643 FQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVSD 3699
Query: 338 LRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAM 377
+ A+Q++QQ Q D A V RKL A+
Sbjct: 3700 TIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 3739
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 46.2 bits (108), Expect = 2e-04
Identities = 107/624 (17%), Positives = 244/624 (39%), Gaps = 89/624 (14%)
Query: 56 RVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGI 115
++ + T + E++ + ++ K+E+ C++L + L+ V + +
Sbjct: 921 KIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK--- 977
Query: 116 LSGTSDLLLTFDEAEVRKIIRVCKGILE-YLTVAEVVETMEDLVTYTKNLGPGMTKMAKM 174
+ ++ + DE + K+ + K + E + + ++ ED V L TK+ +
Sbjct: 978 VKNLTEEMAGLDET-IAKLSKEKKALQETHQQTLDDLQAEEDKVNI---LTKAKTKLEQQ 1033
Query: 175 IDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTV 234
+D+ + L ++ + + ++ ++L L A + + +N K Q ++E L+ + F +
Sbjct: 1034 VDDLEGSL--EQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ-LDEKLEKKEFEI 1090
Query: 235 --------EKMSAEINEIIRVLQLTSWDED------------AWASKDTEAMKRALASID 274
++ + EI ++ +L + E+ A A K + R L I
Sbjct: 1091 SNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEIS 1150
Query: 275 SKLNQAKGWLRDPSA--SPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMT 332
+L +A G +A Q +R+ L+EA E R++ + LG+
Sbjct: 1151 ERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQI 1210
Query: 333 DQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQ 392
D + ++ Q++ + L + ++ + EA++ +K ++ K + +
Sbjct: 1211 DNLQRVK--------------QKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLE 1256
Query: 393 NWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQG 452
+ +++ E ++++ L R + E + R L E AL S+L
Sbjct: 1257 DQVSELKTKEEEQQRLINDLTAQRARLQ-----TEAGEYSRQLDEKDALVSQL------- 1304
Query: 453 KGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVH----LEGKIEQAQRWIDNPT 508
S +A +Q+ L+ +T A + +++ H L + E+ Q
Sbjct: 1305 ---SRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQE------ 1355
Query: 509 VDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQ 568
G+A ++ +++ + Y D + + + +++ +LA E
Sbjct: 1356 ------GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEA 1409
Query: 569 ARALASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDE 628
A + SL+ K R+Q EV D+ D + A A N ++V E
Sbjct: 1410 VNAKCA----SLEKTKQRLQ----NEVEDLMLDVE---RSNAACAALDKKQRNFDKVLSE 1458
Query: 629 RAANFENHSGKLGATAEKAAAVGT 652
+E +L A+ +++ ++ T
Sbjct: 1459 WKQKYEETQAELEASQKESRSLST 1482
Score = 38.5 bits (88), Expect = 0.037
Identities = 68/300 (22%), Positives = 129/300 (43%), Gaps = 35/300 (11%)
Query: 308 KVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKV 367
K+ L E + + T K Q T D A+ + +K + + + L +V
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTK---DELAKSEAKRKELEEKMVTLLKEKNDLQLQV 894
Query: 368 ENAARKL-EAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGAL-AEARKIAELCDD- 424
++ A L +A +Q I KI + + E EE+I L A+ RK+ + C +
Sbjct: 895 QSEADSLADAEERCEQLIKNKIQLEAK-IKEVTERAEEEEEINAELTAKKRKLEDECSEL 953
Query: 425 PKERDDILRSLGEISA-----------LTSKLADLRRQGKGDSPEARALAKQVATALQNL 473
K+ DD+ +L ++ LT ++A L S E +AL + L +L
Sbjct: 954 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013
Query: 474 QTKTNRA----VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRL 529
Q + ++ A ++ + LEG +EQ ++ R + A R L + +L
Sbjct: 1014 QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKL--------RMDLERAKRKLEGD-LKL 1064
Query: 530 ANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQE 589
A D +++++ ++++L ++ E E +A+ QLQ +K+L+AR++E
Sbjct: 1065 AQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDE----QAVEIQLQKKIKELQARIEE 1120
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,081,206
Number of Sequences: 37866
Number of extensions: 1985823
Number of successful extensions: 17742
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 505
Number of HSP's that attempted gapping in prelim test: 11688
Number of HSP's gapped (non-prelim): 3959
length of query: 1134
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1021
effective length of database: 13,968,660
effective search space: 14262001860
effective search space used: 14262001860
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.