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Search of human proteins with 62988361
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62988361 absent in melanoma 1 [Homo sapiens]
(1723 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62988361 absent in melanoma 1 [Homo sapiens] 3473 0.0
gi|89886227 absent in melanoma 1-like [Homo sapiens] 480 e-135
gi|90403579 beta-gamma crystallin domain containing 3 [Homo sapi... 449 e-126
gi|4503063 crystallin, beta B2 [Homo sapiens] 105 4e-22
gi|4503061 crystallin, beta B1 [Homo sapiens] 98 6e-20
gi|148491057 crystallin, gamma A [Homo sapiens] 97 1e-19
gi|4503059 crystallin, beta A4 [Homo sapiens] 97 1e-19
gi|148491074 crystallin, gamma B [Homo sapiens] 97 2e-19
gi|8922120 crystallin, gamma S [Homo sapiens] 94 1e-18
gi|12056461 crystallin, beta A3 [Homo sapiens] 94 1e-18
gi|4758074 crystallin, beta B3 [Homo sapiens] 93 2e-18
gi|16936542 crystallin, beta A2 [Homo sapiens] 90 2e-17
gi|16936540 crystallin, beta A2 [Homo sapiens] 90 2e-17
gi|7019357 crystallin, beta A2 [Homo sapiens] 90 2e-17
gi|13377002 crystallin, gamma D [Homo sapiens] 89 5e-17
gi|10518338 crystallin, gamma C [Homo sapiens] 86 2e-16
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 77 1e-13
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 77 1e-13
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 77 2e-13
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 72 6e-12
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 72 6e-12
gi|21389517 gammaN-crystallin [Homo sapiens] 67 2e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 64 1e-09
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 63 2e-09
gi|163965366 nascent polypeptide-associated complex alpha subuni... 60 2e-08
gi|239743293 PREDICTED: mucin 12 [Homo sapiens] 58 9e-08
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 56 3e-07
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 56 3e-07
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 56 3e-07
gi|158854042 hypothetical protein LOC222183 [Homo sapiens] 56 3e-07
>gi|62988361 absent in melanoma 1 [Homo sapiens]
Length = 1723
Score = 3473 bits (9005), Expect = 0.0
Identities = 1723/1723 (100%), Positives = 1723/1723 (100%)
Query: 1 MEKRSSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVK 60
MEKRSSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVK
Sbjct: 1 MEKRSSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVK 60
Query: 61 SPRAALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAP 120
SPRAALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAP
Sbjct: 61 SPRAALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAP 120
Query: 121 PASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKR 180
PASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKR
Sbjct: 121 PASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKR 180
Query: 181 GPLPNHFNGRAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHV 240
GPLPNHFNGRAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHV
Sbjct: 181 GPLPNHFNGRAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHV 240
Query: 241 ELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASS 300
ELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASS
Sbjct: 241 ELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASS 300
Query: 301 KTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMN 360
KTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMN
Sbjct: 301 KTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMN 360
Query: 361 GDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVL 420
GDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVL
Sbjct: 361 GDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVL 420
Query: 421 ENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDT 480
ENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDT
Sbjct: 421 ENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDT 480
Query: 481 CVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSE 540
CVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSE
Sbjct: 481 CVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSE 540
Query: 541 CPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEE 600
CPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEE
Sbjct: 541 CPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEE 600
Query: 601 VLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLA 660
VLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLA
Sbjct: 601 VLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLA 660
Query: 661 TPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPMKRKKA 720
TPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPMKRKKA
Sbjct: 661 TPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPMKRKKA 720
Query: 721 RMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLR 780
RMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLR
Sbjct: 721 RMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLR 780
Query: 781 PKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNGGIKRSRLEKSALFSSLLS 840
PKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNGGIKRSRLEKSALFSSLLS
Sbjct: 781 PKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNGGIKRSRLEKSALFSSLLS 840
Query: 841 SLPQDKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTTEGAPPCGLNKEQSNLLPDNS 900
SLPQDKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTTEGAPPCGLNKEQSNLLPDNS
Sbjct: 841 SLPQDKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTTEGAPPCGLNKEQSNLLPDNS 900
Query: 901 LKVFNFNSSSTSHSSLKSPSHMEKYPQKEKTKEDLDSRSNLHLPETKFSELSKLKNDDME 960
LKVFNFNSSSTSHSSLKSPSHMEKYPQKEKTKEDLDSRSNLHLPETKFSELSKLKNDDME
Sbjct: 901 LKVFNFNSSSTSHSSLKSPSHMEKYPQKEKTKEDLDSRSNLHLPETKFSELSKLKNDDME 960
Query: 961 KANHIESVIKSNLPNCANSDTDFMGLFKSSRYDPSISFSGMSLSDTMTLRGSVQNKLNPR 1020
KANHIESVIKSNLPNCANSDTDFMGLFKSSRYDPSISFSGMSLSDTMTLRGSVQNKLNPR
Sbjct: 961 KANHIESVIKSNLPNCANSDTDFMGLFKSSRYDPSISFSGMSLSDTMTLRGSVQNKLNPR 1020
Query: 1021 PGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLE 1080
PGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLE
Sbjct: 1021 PGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLE 1080
Query: 1081 EGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSY 1140
EGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSY
Sbjct: 1081 EGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSY 1140
Query: 1141 FDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIG 1200
FDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIG
Sbjct: 1141 FDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIG 1200
Query: 1201 SMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPF 1260
SMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPF
Sbjct: 1201 SMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPF 1260
Query: 1261 TSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAH 1320
TSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAH
Sbjct: 1261 TSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAH 1320
Query: 1321 MIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILD 1380
MIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILD
Sbjct: 1321 MIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILD 1380
Query: 1381 KGFYTSFEDWGGKNCKISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHSQSFEETTSQID 1440
KGFYTSFEDWGGKNCKISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHSQSFEETTSQID
Sbjct: 1381 KGFYTSFEDWGGKNCKISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHSQSFEETTSQID 1440
Query: 1441 DSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGHYPCLSAMGCPPGATFKSLRFIDVEFS 1500
DSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGHYPCLSAMGCPPGATFKSLRFIDVEFS
Sbjct: 1441 DSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGHYPCLSAMGCPPGATFKSLRFIDVEFS 1500
Query: 1501 EPTIILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLL 1560
EPTIILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLL
Sbjct: 1501 EPTIILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLL 1560
Query: 1561 SPAEVPNWYEFSGCRQIGSLRPFVQKRIYFRLRNKATGLFMSTNGNLEDLKLLRIQVMED 1620
SPAEVPNWYEFSGCRQIGSLRPFVQKRIYFRLRNKATGLFMSTNGNLEDLKLLRIQVMED
Sbjct: 1561 SPAEVPNWYEFSGCRQIGSLRPFVQKRIYFRLRNKATGLFMSTNGNLEDLKLLRIQVMED 1620
Query: 1621 VGADDQIWIYQEGCIKCRIAEDCCLTIVGSLVTSGSKLGLALDQNADSQFWSLKSDGRIY 1680
VGADDQIWIYQEGCIKCRIAEDCCLTIVGSLVTSGSKLGLALDQNADSQFWSLKSDGRIY
Sbjct: 1621 VGADDQIWIYQEGCIKCRIAEDCCLTIVGSLVTSGSKLGLALDQNADSQFWSLKSDGRIY 1680
Query: 1681 SKLKPNLVLDIKGGTQYDQNHIILNTVSKEKFTQVWEAMVLYT 1723
SKLKPNLVLDIKGGTQYDQNHIILNTVSKEKFTQVWEAMVLYT
Sbjct: 1681 SKLKPNLVLDIKGGTQYDQNHIILNTVSKEKFTQVWEAMVLYT 1723
>gi|89886227 absent in melanoma 1-like [Homo sapiens]
Length = 616
Score = 480 bits (1236), Expect = e-135
Identities = 247/615 (40%), Positives = 369/615 (60%), Gaps = 10/615 (1%)
Query: 1107 PVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSYFDDTEEMQGFGVMQKTCSMKVHWGTW 1166
P IGS+R VV DY I LF+E G + + QG + S V G W
Sbjct: 12 PQGIGSLRRVVWDYSTPEISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLW 71
Query: 1167 LIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIGSMRPLKMGGRKVEFPTDPKVVVYEKP 1226
L+Y +P F+ P+ILEPGEYP W T +GS++P+++G VE P +P+ VVYE P
Sbjct: 72 LLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGEPRAVVYEAP 131
Query: 1227 FFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQY 1286
F+G+ E+ + + + E + HL SVGS++VL G WV YEK GF GHQY
Sbjct: 132 GFQGRSWEVSRDIYNL-----QQPEDSQSPHL--ASVGSLRVLGGCWVGYEKEGFRGHQY 184
Query: 1287 LLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDVLGIVANLK 1346
LLEEGEY DW WGGY+ L SLR I DF + ++++ +F +G ++V + +++
Sbjct: 185 LLEEGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDF--EGHGVEVSKALPDVE 242
Query: 1347 ETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNCKISSVQPICLD 1406
+G TQ+I+VLSGVWVAY+ F+GEQY+L+KG Y + EDWG N ++S+QP+
Sbjct: 243 LVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVLQV 302
Query: 1407 SFTGPRRRNQIHLFSEPQFQGHSQSFEETTSQIDDSFSTKSCRVSGGSWVVYDGENFTGN 1466
++I LFS P F G SFE+ + + SF +SCRV GGSW+++D NF G+
Sbjct: 303 GEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALPASFRPQSCRVHGGSWILFDETNFEGD 362
Query: 1467 QYVLEEGHYPCLSAMGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNL 1526
Q++L EG +P L+AMGC SL+ + + FSEP+I L+ E F+GK+IEL+ E +L
Sbjct: 363 QHILSEGEFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVRSL 422
Query: 1527 RSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCRQIGSLRPFVQK 1586
++ GFN + SV++ GGIWV E+ +RGRQ+L+ E+ NW +SG +++GSL P Q+
Sbjct: 423 QAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQRVGSLYPIKQR 482
Query: 1587 RIYFRLRNKATGLFMSTNGNLEDLKLLRIQVMEDVGADDQIWIYQEGCIKCRIAEDCCLT 1646
R+YFRL N A G F++ ++ED+K R+ V + IW Y++G +K ++A L
Sbjct: 483 RVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQ 542
Query: 1647 IVGSLVTSGSKLGLALDQNADSQFWSLKSDGRIYSKLKPNLVLDIKGGTQYDQNHIILNT 1706
++G + GSK+ L + Q WS+ G I S++ +LD+KGG YD++H++L
Sbjct: 543 VIGP-PSPGSKVVLWAESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWE 601
Query: 1707 VSKEKFTQVWEAMVL 1721
+++ +Q+W VL
Sbjct: 602 PDEDRASQIWTIHVL 616
Score = 141 bits (355), Expect = 6e-33
Identities = 123/429 (28%), Positives = 199/429 (46%), Gaps = 55/429 (12%)
Query: 1059 VVRGCWILYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIG--SIRHV 1116
V G W+LY +P FE LE GE S WG D S KP+ +G S+
Sbjct: 66 VSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSD-----PSVGSLKPMRLGCPSVEKP 120
Query: 1117 VQDYRVSHIDLFTEPEGLGILSSYFD--DTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGF 1174
+ V + + + ++ E+ Q + S++V G W+ YE+ GF
Sbjct: 121 GEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQS-PHLASVGSLRVLGGCWVGYEKEGF 179
Query: 1175 QGVPFILEPGEYPDLSFWDTEAAYIGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVE 1234
+G ++LE GEYPD S W + S+R + + +F DP VV++E FEG VE
Sbjct: 180 RGHQYLLEEGEYPDWSHWGGYDELLTSLRVI-----RTDF-GDPAVVLFEAMDFEGHGVE 233
Query: 1235 LETGM--CSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGE 1292
+ + V G T+ ++ VL G+WVAY++ GF+G QY+LE+G
Sbjct: 234 VSKALPDVELVQHGPSTQ--------------AIHVLSGVWVAYQEVGFSGEQYVLEKGV 279
Query: 1293 YRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSK---GSSIDVLGIVANLKETG 1349
YR+ + WG N L SL+P+L + + +F SK S D LG + ++
Sbjct: 280 YRNCEDWGAGNSTLASLQPVL-------QVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQ 332
Query: 1350 YGV----KTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGG-KNCKISSVQPIC 1404
+ + QS V G W+ ++ +F G+Q+IL +G + + G + + S+Q +
Sbjct: 333 AALPASFRPQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVLGSLQKVS 392
Query: 1405 LDSFTGPRRRNQIHLFSEPQFQGHS-QSFEETTSQIDDSFSTK--SCRVSGGSWVVYDGE 1461
L F+ P I L+ F+G + E S + F+ S R+ GG WV+ +
Sbjct: 393 L-HFSEP----SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHS 447
Query: 1462 NFTGNQYVL 1470
+F G Q+++
Sbjct: 448 DFRGRQWLV 456
Score = 125 bits (314), Expect = 4e-28
Identities = 108/397 (27%), Positives = 182/397 (45%), Gaps = 49/397 (12%)
Query: 1020 RPG--KVVIYSEPDVSEKCIEVFSDI------QDCSSWSLSPVILIKVVRGCWILYEQPN 1071
+PG + V+Y P + EV DI +D S L+ V ++V+ GCW+ YE+
Sbjct: 119 KPGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEG 178
Query: 1072 FEGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLF--T 1129
F GH LEEGE WG D L + S+R + D+ + LF
Sbjct: 179 FRGHQYLLEEGEYPDWSHWGGYDEL-------------LTSLRVIRTDFGDPAVVLFEAM 225
Query: 1130 EPEGLGI-LSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPD 1188
+ EG G+ +S D E +Q T ++ V G W+ Y+E GF G ++LE G Y +
Sbjct: 226 DFEGHGVEVSKALPDVELVQH---GPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRN 282
Query: 1189 LSFWDTEAAYIGSMRP-LKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGG 1247
W + + S++P L++G + F + K+ ++ +P F G E
Sbjct: 283 CEDWGAGNSTLASLQPVLQVGEHDLHFVS--KIQLFSRPDFLGDHFSFE----------- 329
Query: 1248 ETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGEYRDWKAWGGY-NGEL 1306
+ + A P S +V G W+ +++ F G Q++L EGE+ A G + L
Sbjct: 330 DDQAALPASFRP----QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVL 385
Query: 1307 QSLRPILGDFSNAHMIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVA 1366
SL+ + FS + +Y + F +G I++ V +L+ G+ S+ + G+WV
Sbjct: 386 GSLQKVSLHFSEPSIFLYGLECF--EGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVL 443
Query: 1367 YENPDFTGEQYILDKGFYTSFEDWGGKNCKISSVQPI 1403
E+ DF G Q+++ T++ + G ++ S+ PI
Sbjct: 444 CEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSLYPI 479
>gi|90403579 beta-gamma crystallin domain containing 3 [Homo sapiens]
Length = 1022
Score = 449 bits (1156), Expect = e-126
Identities = 288/790 (36%), Positives = 429/790 (54%), Gaps = 59/790 (7%)
Query: 949 SELSKLKNDDMEKANHIESVIKSNLPNCANSDTDFMGLFKS--SRY-----DPSISFSGM 1001
S+L+ + ++ A H ++++ + + F G+F+ S+Y P +
Sbjct: 275 SDLTSKLHSSLKSAYH--QYLQTSQSHSSEKGARFGGIFQEPVSKYFRVQDSPGRLSPFI 332
Query: 1002 SLSDTMTLRGSVQNKLNPRPGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVR 1061
D TLR NPRPGK+VIY + + K EV+ +I D +SWS +LIKVVR
Sbjct: 333 ENVDKQTLR------CNPRPGKMVIYDLHESTYKQ-EVYCNIPDATSWSFPNGVLIKVVR 385
Query: 1062 GCWILYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYR 1121
GCWILYE+P+F G LEEGE L+ W +++ RH + + ++GS++ V++D
Sbjct: 386 GCWILYEKPHFRGQKCVLEEGEKVLNRDWILQN--RRHPQ----RNFILGSLKRVLKDCS 439
Query: 1122 VSHIDLFTEPEGLGI---LSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVP 1178
+ I+LF + + + + EE+ + K+ S V G WL Y + F+G
Sbjct: 440 IPEIELFPQSDPACCPVYIQRAVPNLEELN----ISKSVSFTVKSGVWLAYPDINFKGQA 495
Query: 1179 FILEPGEYPDLSFWDTEAAYIGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETG 1238
+LE D ++ A + S+ PL+MGG KVE P + KV++YEKP F G+ E
Sbjct: 496 TVLEE----DHGLFEISTAEMKSLHPLQMGGLKVEMPMNLKVIIYEKPHFHGQAKEFSEH 551
Query: 1239 MCS---FVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGEYRD 1295
+ S F+ G+ F +GS++V+ G+WVAYEK F G Q+LLEEG++ D
Sbjct: 552 IDSVPNFLKNNGD-----------FHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFED 600
Query: 1296 WKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDVLGI-VANLKETGYGVKT 1354
A G + + S R + +F + + ++ E + S G ID+ +++L+E G+G KT
Sbjct: 601 SNACGALSSPILSFRYLQANFIESSVTLF-ESDLES-GKFIDITNQEISDLEEIGFGSKT 658
Query: 1355 QSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNCKISSVQPICLDSFTGPRRR 1414
+SI+V SGVWVAY+ F GEQYIL+KG Y F DWGG N I S++PI L+
Sbjct: 659 RSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPP 718
Query: 1415 NQIHLFSEPQFQGHSQSFEETTSQIDDSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGH 1474
+ + FS+P FQG F E TS + S S +V G W++Y E+ N VLEEG
Sbjct: 719 HLLKAFSKPGFQGECIDFTEETSDLT-SLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGL 777
Query: 1475 YPCLSAMGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNL---RSLGF 1531
Y L++ GCP + KSL+ ID F EP+I LF E +G+++ L E VN + L F
Sbjct: 778 YADLTSCGCP-ASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLE-EAVNSVLNKDLHF 835
Query: 1532 NTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCRQIGSLRPFVQKRIYFR 1591
TQ SV V G+W+ YE ++ GRQ LL P E+PNW FS + IGSLRP Q +Y R
Sbjct: 836 YTQ--SVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIR 893
Query: 1592 LRNKATGLFMSTNGNLEDLKLLRIQVMEDVGADDQIWIYQEGCIKCRIAEDCCLTIVGSL 1651
++N+A G +++ G+L D + + + G + QIW Y G K + A D CL ++G
Sbjct: 894 IKNRAQGEYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFKSK-ASDTCLDVIGGR 952
Query: 1652 VTSGSKLGLALDQNADSQFWSLKSDGRIYSKLKPNLVLDIKGGTQYDQNHIILNTVSKEK 1711
T G+K+ L + Q W L +G I S L LVLD+KGG D+ H+I+N + +
Sbjct: 953 DTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPLEGE 1012
Query: 1712 FTQVWEAMVL 1721
TQ W+ +L
Sbjct: 1013 ETQKWDIEIL 1022
>gi|4503063 crystallin, beta B2 [Homo sapiens]
Length = 205
Score = 105 bits (262), Expect = 4e-22
Identities = 66/189 (34%), Positives = 95/189 (50%), Gaps = 16/189 (8%)
Query: 1217 DPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAY 1276
+PK++++E+ F+G EL G C + E G E+A GS+ V G WV Y
Sbjct: 16 NPKIIIFEQENFQGHSHELN-GPCPNLKETG-VEKA-----------GSVLVQAGPWVGY 62
Query: 1277 EKPGFTGHQYLLEEGEYRDWKAWGGYN--GELQSLRPILGDFSNAHMIMYSEKNFGSKGS 1334
E+ G Q++ E+GEY W +W L SLRPI D +I+Y NF K
Sbjct: 63 EQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGKKM 122
Query: 1335 SIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKN 1394
I + V + GY K S+ V SG WV Y+ P + G QY+L+KG Y D+G +
Sbjct: 123 EI-IDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPH 181
Query: 1395 CKISSVQPI 1403
++ SV+ I
Sbjct: 182 PQVQSVRRI 190
Score = 89.7 bits (221), Expect = 2e-17
Identities = 53/163 (32%), Positives = 88/163 (53%), Gaps = 21/163 (12%)
Query: 1153 MQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAY--IGSMRPLKMGGR 1210
++K S+ V G W+ YE+ +G F+ E GEYP W + + S+RP+K+ +
Sbjct: 46 VEKAGSVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQ 105
Query: 1211 KVEFPTDPKVVVYEKPFFEGKCVEL-ETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVL 1269
+ K+++YE P F GK +E+ + + SF G + + V S++V
Sbjct: 106 ------EHKIILYENPNFTGKKMEIIDDDVPSFHAHGYQEK------------VSSVRVQ 147
Query: 1270 RGIWVAYEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPI 1312
G WV Y+ PG+ G QYLLE+G+Y+D +G + ++QS+R I
Sbjct: 148 SGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQVQSVRRI 190
Score = 89.0 bits (219), Expect = 4e-17
Identities = 57/171 (33%), Positives = 87/171 (50%), Gaps = 5/171 (2%)
Query: 1416 QIHLFSEPQFQGHSQSFEETTSQIDDSFSTK--SCRVSGGSWVVYDGENFTGNQYVLEEG 1473
+I +F + FQGHS + ++ K S V G WV Y+ N G Q+V E+G
Sbjct: 18 KIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWVGYEQANCKGEQFVFEKG 77
Query: 1474 HYPCLSAMGCPPGA-TFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETV-NLRSLGF 1531
YP + + SLR I V+ E IIL+E +F GKK+E+ + V + + G+
Sbjct: 78 EYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGKKMEIIDDDVPSFHAHGY 137
Query: 1532 NTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCR-QIGSLR 1581
++ SV+V G WV Y+Y YRG Q+LL + + +F Q+ S+R
Sbjct: 138 QEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQVQSVR 188
Score = 88.6 bits (218), Expect = 5e-17
Identities = 60/190 (31%), Positives = 96/190 (50%), Gaps = 14/190 (7%)
Query: 1318 NAHMIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQY 1377
N +I++ ++NF +G S ++ G NLKETG K S+ V +G WV YE + GEQ+
Sbjct: 16 NPKIIIFEQENF--QGHSHELNGPCPNLKETGVE-KAGSVLVQAGPWVGYEQANCKGEQF 72
Query: 1378 ILDKGFYTSFEDWGG--KNCKISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHSQSF--E 1433
+ +KG Y ++ W + +SS++PI +DS + ++I L+ P F G +
Sbjct: 73 VFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDS-----QEHKIILYENPNFTGKKMEIIDD 127
Query: 1434 ETTSQIDDSFSTK--SCRVSGGSWVVYDGENFTGNQYVLEEGHYPCLSAMGCPPGATFKS 1491
+ S + K S RV G+WV Y + G QY+LE+G Y S G P
Sbjct: 128 DVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQVQSV 187
Query: 1492 LRFIDVEFSE 1501
R D+++ +
Sbjct: 188 RRIRDMQWHQ 197
Score = 72.0 bits (175), Expect = 5e-12
Identities = 53/204 (25%), Positives = 87/204 (42%), Gaps = 16/204 (7%)
Query: 1004 SDTMTLRGSVQNKLNPRPGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGC 1063
SD T G Q+ LNP K++I+ + + E+ + + + V G
Sbjct: 3 SDHQTQAGKPQS-LNP---KIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGP 58
Query: 1064 WILYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVS 1123
W+ YEQ N +G E+GE W R + S +P+ + S H
Sbjct: 59 WVGYEQANCKGEQFVFEKGEYPRWDSWTSS---RRTDSLSSLRPIKVDSQEH-------- 107
Query: 1124 HIDLFTEPEGLGILSSYFDD-TEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILE 1182
I L+ P G DD G +K S++V GTW+ Y+ PG++G+ ++LE
Sbjct: 108 KIILYENPNFTGKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLE 167
Query: 1183 PGEYPDLSFWDTEAAYIGSMRPLK 1206
G+Y D S + + S+R ++
Sbjct: 168 KGDYKDSSDFGAPHPQVQSVRRIR 191
Score = 59.3 bits (142), Expect = 3e-08
Identities = 33/84 (39%), Positives = 46/84 (54%), Gaps = 4/84 (4%)
Query: 1502 PTIILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLS 1561
P II+FE+E+F+G ELN NL+ G + SV V G WV YE + +G QF+
Sbjct: 17 PKIIIFEQENFQGHSHELNGPCPNLKETGVE-KAGSVLVQAGPWVGYEQANCKGEQFVFE 75
Query: 1562 PAEVPNWYEFSGCRQ---IGSLRP 1582
E P W ++ R+ + SLRP
Sbjct: 76 KGEYPRWDSWTSSRRTDSLSSLRP 99
>gi|4503061 crystallin, beta B1 [Homo sapiens]
Length = 252
Score = 98.2 bits (243), Expect = 6e-20
Identities = 53/155 (34%), Positives = 84/155 (54%), Gaps = 19/155 (12%)
Query: 1158 SMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTE--AAYIGSMRPLKMGGRKVEFP 1215
S+ V G W+ +E+ F+G FILE GEYP + W + + + S RP+KM +
Sbjct: 93 SIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDAQ----- 147
Query: 1216 TDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVA 1275
+ K+ ++E F+G +E++ + G ++ VGS+KV G WV
Sbjct: 148 -EHKISLFEGANFKGNTIEIQGDDAPSLWVYGFSDR-----------VGSVKVSSGTWVG 195
Query: 1276 YEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLR 1310
Y+ PG+ G+QYLLE G++R W WG + ++QSLR
Sbjct: 196 YQYPGYRGYQYLLEPGDFRHWNEWGAFQPQMQSLR 230
Score = 97.1 bits (240), Expect = 1e-19
Identities = 60/190 (31%), Positives = 98/190 (51%), Gaps = 18/190 (9%)
Query: 1215 PTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWV 1274
P + ++VV+E F+G+ E +G CS + + G F V S+ V G WV
Sbjct: 56 PGNYRLVVFELENFQGRRAEF-SGECSNLADRG------------FDRVRSIIVSAGPWV 102
Query: 1275 AYEKPGFTGHQYLLEEGEYRDWKAWGGY--NGELQSLRPILGDFSNAHMIMYSEKNFGSK 1332
A+E+ F G ++LE+GEY W W + L S RPI D + ++ NF K
Sbjct: 103 AFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDAQEHKISLFEGANF--K 160
Query: 1333 GSSIDVLGIVA-NLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWG 1391
G++I++ G A +L G+ + S+ V SG WV Y+ P + G QY+L+ G + + +WG
Sbjct: 161 GNTIEIQGDDAPSLWVYGFSDRVGSVKVSSGTWVGYQYPGYRGYQYLLEPGDFRHWNEWG 220
Query: 1392 GKNCKISSVQ 1401
++ S++
Sbjct: 221 AFQPQMQSLR 230
Score = 94.0 bits (232), Expect = 1e-18
Identities = 61/182 (33%), Positives = 92/182 (50%), Gaps = 5/182 (2%)
Query: 1411 PRRRNQIHLFSEPQFQGHSQSFE-ETTSQIDDSFS-TKSCRVSGGSWVVYDGENFTGNQY 1468
P ++ +F FQG F E ++ D F +S VS G WV ++ NF G +
Sbjct: 55 PPGNYRLVVFELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMF 114
Query: 1469 VLEEGHYPCLSAMGCPPGAT-FKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETV-NL 1526
+LE+G YP + + S R I ++ E I LFE +FKG IE+ + +L
Sbjct: 115 ILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDAQEHKISLFEGANFKGNTIEIQGDDAPSL 174
Query: 1527 RSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCR-QIGSLRPFVQ 1585
GF+ ++ SV+V G WV Y+Y YRG Q+LL P + +W E+ + Q+ SLR
Sbjct: 175 WVYGFSDRVGSVKVSSGTWVGYQYPGYRGYQYLLEPGDFRHWNEWGAFQPQMQSLRRLRD 234
Query: 1586 KR 1587
K+
Sbjct: 235 KQ 236
Score = 69.7 bits (169), Expect = 2e-11
Identities = 49/202 (24%), Positives = 89/202 (44%), Gaps = 12/202 (5%)
Query: 1006 TMTLRGSVQNKLNPRPGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWI 1065
T+ + + +L P ++V++ + + E + + + V I V G W+
Sbjct: 43 TVPITSAKAAELPPGNYRLVVFELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWV 102
Query: 1066 LYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHI 1125
+EQ NF G LE+GE W SD+ + I+ Q++++S
Sbjct: 103 AFEQSNFRGEMFILEKGEYPRWNTWS--------SSYRSDRLMSFRPIKMDAQEHKIS-- 152
Query: 1126 DLFTEPEGLG-ILSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPG 1184
LF G + DD + +G + S+KV GTW+ Y+ PG++G ++LEPG
Sbjct: 153 -LFEGANFKGNTIEIQGDDAPSLWVYGFSDRVGSVKVSSGTWVGYQYPGYRGYQYLLEPG 211
Query: 1185 EYPDLSFWDTEAAYIGSMRPLK 1206
++ + W + S+R L+
Sbjct: 212 DFRHWNEWGAFQPQMQSLRRLR 233
>gi|148491057 crystallin, gamma A [Homo sapiens]
Length = 174
Score = 97.4 bits (241), Expect = 1e-19
Identities = 54/185 (29%), Positives = 93/185 (50%), Gaps = 17/185 (9%)
Query: 1219 KVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEK 1278
K+ YE F+G+C + + + F+ S++V G W+ YE+
Sbjct: 3 KITFYEDRDFQGRCYNCISDCPNL--------------RVYFSRCNSIRVDSGCWMLYER 48
Query: 1279 PGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDV 1338
P + GHQY L G+Y D++ W G + +QS R I+ S+ + +Y ++ +G ++
Sbjct: 49 PNYQGHQYFLRRGKYPDYQHWMGLSDSVQSCR-IIPHTSSHKLRLYERDDY--RGLMSEL 105
Query: 1339 LGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNCKIS 1398
A + E + S++VL G WV YE P++ G QY+L G Y + DWGG + K+
Sbjct: 106 TDDCACVPELFRLPEIYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGGADAKVG 165
Query: 1399 SVQPI 1403
S++ +
Sbjct: 166 SLRRV 170
Score = 84.7 bits (208), Expect = 7e-16
Identities = 51/155 (32%), Positives = 76/155 (49%), Gaps = 19/155 (12%)
Query: 1158 SMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIGSMRPLKMGGRKVEFPTD 1217
S++V G W++YE P +QG + L G+YPD W + + S R + +
Sbjct: 35 SIRVDSGCWMLYERPNYQGHQYFLRRGKYPDYQHWMGLSDSVQSCRI-------IPHTSS 87
Query: 1218 PKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYE 1277
K+ +YE+ + G EL T C+ V E E + S+ VL G WV YE
Sbjct: 88 HKLRLYERDDYRGLMSEL-TDDCACVPELFRLPE-----------IYSLHVLEGCWVLYE 135
Query: 1278 KPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPI 1312
P + G QYLL G+YR + WGG + ++ SLR +
Sbjct: 136 MPNYRGRQYLLRPGDYRRYHDWGGADAKVGSLRRV 170
Score = 83.2 bits (204), Expect = 2e-15
Identities = 55/169 (32%), Positives = 85/169 (50%), Gaps = 6/169 (3%)
Query: 1416 QIHLFSEPQFQGHSQSFEETTSQIDDSFST-KSCRVSGGSWVVYDGENFTGNQYVLEEGH 1474
+I + + FQG + + FS S RV G W++Y+ N+ G+QY L G
Sbjct: 3 KITFYEDRDFQGRCYNCISDCPNLRVYFSRCNSIRVDSGCWMLYERPNYQGHQYFLRRGK 62
Query: 1475 YPCLSA-MGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNLRSLGFNT 1533
YP MG +S R I S + L+ER+D++G EL + + L
Sbjct: 63 YPDYQHWMGLSDSV--QSCRIIP-HTSSHKLRLYERDDYRGLMSELTDDCACVPELFRLP 119
Query: 1534 QIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGC-RQIGSLR 1581
+I S+ V+ G WV YE +YRGRQ+LL P + ++++ G ++GSLR
Sbjct: 120 EIYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGGADAKVGSLR 168
Score = 75.9 bits (185), Expect = 3e-13
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 19/184 (10%)
Query: 1022 GKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLEE 1081
GK+ Y + D +C SD + + S I+V GCW+LYE+PN++GH L
Sbjct: 2 GKITFYEDRDFQGRCYNCISDCPNLRVY-FSRCNSIRVDSGCWMLYERPNYQGHQYFLRR 60
Query: 1082 GELELSGLW-GIEDILERHEEAESDKPVVIGSIRHVVQDYRVSH-IDLFTEPEGLGILSS 1139
G+ W G+ D ++ S R + + SH + L+ + G++S
Sbjct: 61 GKYPDYQHWMGLSDSVQ--------------SCRII--PHTSSHKLRLYERDDYRGLMSE 104
Query: 1140 YFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYI 1199
DD + + + S+ V G W++YE P ++G ++L PG+Y W A +
Sbjct: 105 LTDDCACVPELFRLPEIYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGGADAKV 164
Query: 1200 GSMR 1203
GS+R
Sbjct: 165 GSLR 168
>gi|4503059 crystallin, beta A4 [Homo sapiens]
Length = 196
Score = 97.1 bits (240), Expect = 1e-19
Identities = 67/184 (36%), Positives = 96/184 (52%), Gaps = 27/184 (14%)
Query: 1219 KVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEK 1278
K+VV+++ F+G+ E T C V+E G F +V S+KVL G WV +E
Sbjct: 13 KMVVWDEDGFQGRRHEF-TAECPSVLELG------------FETVRSLKVLSGAWVGFEH 59
Query: 1279 PGFTGHQYLLEEGEYRDWKAWGG---YNGE-LQSLRP-ILGDFSNAHMIMYSEKNF-GSK 1332
GF G QY+LE GEY W AWGG Y E L S RP + ++ + ++ ++NF G K
Sbjct: 60 AGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKK 119
Query: 1333 GSSIDVLGIVANLKETGY-GVKTQSINVLSGVWVAYENPDFTGEQYILD----KGFYTSF 1387
G D +L+ G+ G + S +V SG WV + P + G QY+L+ G Y F
Sbjct: 120 GELSD---DYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHHSGDYKHF 176
Query: 1388 EDWG 1391
+WG
Sbjct: 177 REWG 180
Score = 82.8 bits (203), Expect = 3e-15
Identities = 56/165 (33%), Positives = 78/165 (47%), Gaps = 26/165 (15%)
Query: 1158 SMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAY----IGSMRPLKMGGRKVE 1213
S+KV G W+ +E GFQG +ILE GEYP W AY + S RP +
Sbjct: 46 SLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHR-- 103
Query: 1214 FPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIW 1273
D ++ ++E+ F GK EL S G E E VGS V G W
Sbjct: 104 ---DSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNE-----------VGSFHVHSGAW 149
Query: 1274 VAYEKPGFTGHQYLLE----EGEYRDWKAWGGY--NGELQSLRPI 1312
V + PG+ G QY+LE G+Y+ ++ WG + ++QS+R I
Sbjct: 150 VCSQFPGYRGFQYVLECDHHSGDYKHFREWGSHAPTFQVQSIRRI 194
Score = 76.3 bits (186), Expect = 2e-13
Identities = 49/149 (32%), Positives = 77/149 (51%), Gaps = 7/149 (4%)
Query: 1419 LFSEPQFQGHSQSFE-ETTSQIDDSFST-KSCRVSGGSWVVYDGENFTGNQYVLEEGHYP 1476
++ E FQG F E S ++ F T +S +V G+WV ++ F G QY+LE G YP
Sbjct: 16 VWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYP 75
Query: 1477 CLSAMG---CPPGATFKSLR-FIDVEFSEPTIILFEREDFKGKKIELNAETVNLRSLGF- 1531
A G P S R + + +FE+E+F GKK EL+ + +L+++G+
Sbjct: 76 SWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWE 135
Query: 1532 NTQIRSVQVIGGIWVTYEYGSYRGRQFLL 1560
++ S V G WV ++ YRG Q++L
Sbjct: 136 GNEVGSFHVHSGAWVCSQFPGYRGFQYVL 164
Score = 68.6 bits (166), Expect = 5e-11
Identities = 44/163 (26%), Positives = 77/163 (47%), Gaps = 15/163 (9%)
Query: 1321 MIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILD 1380
M+++ E F +G + ++ E G+ +S+ VLSG WV +E+ F G+QYIL+
Sbjct: 14 MVVWDEDGF--QGRRHEFTAECPSVLELGFET-VRSLKVLSGAWVGFEHAGFQGQQYILE 70
Query: 1381 KGFYTSFEDWGGKNC----KISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHSQSFEETT 1436
+G Y S++ WGG +++S +P + R +++ +F + F G +
Sbjct: 71 RGEYPSWDAWGGNTAYPAERLTSFRPAACAN----HRDSRLTIFEQENFLGKKGELSDDY 126
Query: 1437 SQID----DSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGHY 1475
+ + S V G+WV + G QYVLE H+
Sbjct: 127 PSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHH 169
Score = 61.2 bits (147), Expect = 8e-09
Identities = 45/181 (24%), Positives = 73/181 (40%), Gaps = 13/181 (7%)
Query: 1021 PGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLE 1080
P K+V++ E + E ++ V +KV+ G W+ +E F+G LE
Sbjct: 11 PWKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAGFQGQQYILE 70
Query: 1081 EGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSY 1140
GE WG + E S +P ++R S + +F + LG
Sbjct: 71 RGEYPSWDAWG-GNTAYPAERLTSFRPAACA-------NHRDSRLTIFEQENFLGKKGEL 122
Query: 1141 FDDTEEMQGFG-VMQKTCSMKVHWGTWLIYEEPGFQGVPFILE----PGEYPDLSFWDTE 1195
DD +Q G + S VH G W+ + PG++G ++LE G+Y W +
Sbjct: 123 SDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHHSGDYKHFREWGSH 182
Query: 1196 A 1196
A
Sbjct: 183 A 183
Score = 58.9 bits (141), Expect = 4e-08
Identities = 26/84 (30%), Positives = 52/84 (61%), Gaps = 6/84 (7%)
Query: 1504 IILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPA 1563
+++++ + F+G++ E AE ++ LGF T +RS++V+ G WV +E+ ++G+Q++L
Sbjct: 14 MVVWDEDGFQGRRHEFTAECPSVLELGFET-VRSLKVLSGAWVGFEHAGFQGQQYILERG 72
Query: 1564 EVPNWYEFSG-----CRQIGSLRP 1582
E P+W + G ++ S RP
Sbjct: 73 EYPSWDAWGGNTAYPAERLTSFRP 96
>gi|148491074 crystallin, gamma B [Homo sapiens]
Length = 175
Score = 96.7 bits (239), Expect = 2e-19
Identities = 53/185 (28%), Positives = 87/185 (47%), Gaps = 16/185 (8%)
Query: 1219 KVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEK 1278
K+ YE F+G+ E T + F+ S++V G W+ YE+
Sbjct: 3 KITFYEDRAFQGRSYECTTDCPNLQPY--------------FSRCNSIRVESGCWMIYER 48
Query: 1279 PGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDV 1338
P + GHQY L GEY D++ W G + ++S I M +Y +G ++
Sbjct: 49 PNYQGHQYFLRRGEYPDYQQWMGLSDSIRSCCLIPPHSGAYRMKIYDRDEL--RGQMSEL 106
Query: 1339 LGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNCKIS 1398
++++ + + S+NVL G W+ YE P++ G QY+L G Y F DWG N K+
Sbjct: 107 TDDCISVQDRFHLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVG 166
Query: 1399 SVQPI 1403
S++ +
Sbjct: 167 SLRRV 171
Score = 86.7 bits (213), Expect = 2e-16
Identities = 53/158 (33%), Positives = 76/158 (48%), Gaps = 22/158 (13%)
Query: 1158 SMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIGS--MRPLKMGGRKVEFP 1215
S++V G W+IYE P +QG + L GEYPD W + I S + P G +++
Sbjct: 35 SIRVESGCWMIYERPNYQGHQYFLRRGEYPDYQQWMGLSDSIRSCCLIPPHSGAYRMK-- 92
Query: 1216 TDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVA 1275
+Y++ G+ EL T C V D T + S+ VL G W+
Sbjct: 93 ------IYDRDELRGQMSEL-TDDCISVQ-----------DRFHLTEIHSLNVLEGSWIL 134
Query: 1276 YEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPIL 1313
YE P + G QYLL GEYR + WG N ++ SLR ++
Sbjct: 135 YEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVM 172
Score = 84.3 bits (207), Expect = 9e-16
Identities = 50/169 (29%), Positives = 85/169 (50%), Gaps = 5/169 (2%)
Query: 1416 QIHLFSEPQFQGHSQSFEETTSQIDDSFST-KSCRVSGGSWVVYDGENFTGNQYVLEEGH 1474
+I + + FQG S + FS S RV G W++Y+ N+ G+QY L G
Sbjct: 3 KITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRRGE 62
Query: 1475 YPCLSA-MGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNLRSLGFNT 1533
YP MG + +S I + +++R++ +G+ EL + ++++ T
Sbjct: 63 YPDYQQWMGLSD--SIRSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFHLT 120
Query: 1534 QIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCR-QIGSLR 1581
+I S+ V+ G W+ YE +YRGRQ+LL P E + ++ ++GSLR
Sbjct: 121 EIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLR 169
Score = 73.2 bits (178), Expect = 2e-12
Identities = 48/183 (26%), Positives = 80/183 (43%), Gaps = 16/183 (8%)
Query: 1022 GKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLEE 1081
GK+ Y + + E +D + + S I+V GCW++YE+PN++GH L
Sbjct: 2 GKITFYEDRAFQGRSYECTTDCPNLQPY-FSRCNSIRVESGCWMIYERPNYQGHQYFLRR 60
Query: 1082 GELELSGLW-GIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSY 1140
GE W G+ D + S + + ++ E G +S
Sbjct: 61 GEYPDYQQWMGLSDSIR--------------SCCLIPPHSGAYRMKIYDRDELRGQMSEL 106
Query: 1141 FDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIG 1200
DD +Q + + S+ V G+W++YE P ++G ++L PGEY W A +G
Sbjct: 107 TDDCISVQDRFHLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVG 166
Query: 1201 SMR 1203
S+R
Sbjct: 167 SLR 169
Score = 72.8 bits (177), Expect = 3e-12
Identities = 49/178 (27%), Positives = 79/178 (44%), Gaps = 14/178 (7%)
Query: 1324 YSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGF 1383
Y ++ F +G S + NL+ Y + SI V SG W+ YE P++ G QY L +G
Sbjct: 7 YEDRAF--QGRSYECTTDCPNLQP--YFSRCNSIRVESGCWMIYERPNYQGHQYFLRRGE 62
Query: 1384 YTSFEDWGGKNCKISSVQPICL-DSFTGPRRRNQIHLFSEPQFQGHSQSFEETTSQIDDS 1442
Y ++ W G + S++ CL +G R + ++ + +G + + D
Sbjct: 63 YPDYQQWMGLS---DSIRSCCLIPPHSGAYR---MKIYDRDELRGQMSELTDDCISVQDR 116
Query: 1443 F---STKSCRVSGGSWVVYDGENFTGNQYVLEEGHYPCLSAMGCPPGATFKSLRFIDV 1497
F S V GSW++Y+ N+ G QY+L G Y G P R +D+
Sbjct: 117 FHLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVMDL 174
>gi|8922120 crystallin, gamma S [Homo sapiens]
Length = 178
Score = 94.0 bits (232), Expect = 1e-18
Identities = 56/188 (29%), Positives = 84/188 (44%), Gaps = 15/188 (7%)
Query: 1216 TDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVA 1275
T K+ YE F+G+ + + F H + S+KV G W
Sbjct: 4 TGTKITFYEDKNFQGRRYDCDCDCADF--------------HTYLSRCNSIKVEGGTWAV 49
Query: 1276 YEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSS 1335
YE+P F G+ Y+L +GEY +++ W G N L S R + + I EK S G
Sbjct: 50 YERPNFAGYMYILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFS-GQM 108
Query: 1336 IDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNC 1395
+ ++ E + + S VL GVW+ YE P++ G QY+LDK Y DWG +
Sbjct: 109 YETTEDCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASP 168
Query: 1396 KISSVQPI 1403
+ S + I
Sbjct: 169 AVQSFRRI 176
Score = 89.7 bits (221), Expect = 2e-17
Identities = 56/158 (35%), Positives = 78/158 (49%), Gaps = 21/158 (13%)
Query: 1158 SMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIGSMRPLKM--GGRKVEFP 1215
S+KV GTW +YE P F G +IL GEYP+ W + S R + + GG+
Sbjct: 39 SIKVEGGTWAVYERPNFAGYMYILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGGQY---- 94
Query: 1216 TDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVA 1275
K+ ++EK F G+ E T C +ME E + S KVL G+W+
Sbjct: 95 ---KIQIFEKGDFSGQMYET-TEDCPSIMEQFHMRE-----------IHSCKVLEGVWIF 139
Query: 1276 YEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPIL 1313
YE P + G QYLL++ EYR WG + +QS R I+
Sbjct: 140 YELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFRRIV 177
Score = 77.8 bits (190), Expect = 8e-14
Identities = 49/155 (31%), Positives = 74/155 (47%), Gaps = 11/155 (7%)
Query: 1324 YSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGF 1383
Y +KNF +G D A+ Y + SI V G W YE P+F G YIL +G
Sbjct: 11 YEDKNF--QGRRYDCDCDCADFHT--YLSRCNSIKVEGGTWAVYERPNFAGYMYILPQGE 66
Query: 1384 YTSFEDWGGKNCKISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHSQSFEETTSQIDDSF 1443
Y ++ W G N ++SS + + L S + +I +F + F G E I + F
Sbjct: 67 YPEYQRWMGLNDRLSSCRAVHLPS----GGQYKIQIFEKGDFSGQMYETTEDCPSIMEQF 122
Query: 1444 STK---SCRVSGGSWVVYDGENFTGNQYVLEEGHY 1475
+ SC+V G W+ Y+ N+ G QY+L++ Y
Sbjct: 123 HMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEY 157
Score = 74.3 bits (181), Expect = 9e-13
Identities = 46/163 (28%), Positives = 71/163 (43%), Gaps = 27/163 (16%)
Query: 1416 QIHLFSEPQFQGHSQSFEETTSQIDDSFST-KSCRVSGGSWVVYDGENFTGNQYVLEEGH 1474
+I + + FQG + + S S +V GG+W VY+ NF G Y+L +G
Sbjct: 7 KITFYEDKNFQGRRYDCDCDCADFHTYLSRCNSIKVEGGTWAVYERPNFAGYMYILPQGE 66
Query: 1475 YP-------------CLSAMGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNA 1521
YP A+ P G +K I +FE+ DF G+ E
Sbjct: 67 YPEYQRWMGLNDRLSSCRAVHLPSGGQYK-------------IQIFEKGDFSGQMYETTE 113
Query: 1522 ETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPAE 1564
+ ++ +I S +V+ G+W+ YE +YRGRQ+LL E
Sbjct: 114 DCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKE 156
Score = 53.9 bits (128), Expect = 1e-06
Identities = 48/182 (26%), Positives = 79/182 (43%), Gaps = 15/182 (8%)
Query: 1023 KVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLEEG 1082
K+ Y + + + + D D ++ LS IKV G W +YE+PNF G+ L +G
Sbjct: 7 KITFYEDKNFQGRRYDCDCDCADFHTY-LSRCNSIKVEGGTWAVYERPNFAGYMYILPQG 65
Query: 1083 ELELSGLW-GIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSYF 1141
E W G+ D L S + V + S Y+ I +F + + G +
Sbjct: 66 EYPEYQRWMGLNDRLS------SCRAVHLPS----GGQYK---IQIFEKGDFSGQMYETT 112
Query: 1142 DDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIGS 1201
+D + M++ S KV G W+ YE P ++G ++L+ EY W + + S
Sbjct: 113 EDCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQS 172
Query: 1202 MR 1203
R
Sbjct: 173 FR 174
Score = 39.7 bits (91), Expect = 0.026
Identities = 16/70 (22%), Positives = 38/70 (54%), Gaps = 2/70 (2%)
Query: 1504 IILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPA 1563
I +E ++F+G++ + + + + + + ++ S++V GG W YE ++ G ++L
Sbjct: 8 ITFYEDKNFQGRRYDCDCDCADFHT--YLSRCNSIKVEGGTWAVYERPNFAGYMYILPQG 65
Query: 1564 EVPNWYEFSG 1573
E P + + G
Sbjct: 66 EYPEYQRWMG 75
>gi|12056461 crystallin, beta A3 [Homo sapiens]
Length = 215
Score = 93.6 bits (231), Expect = 1e-18
Identities = 62/195 (31%), Positives = 95/195 (48%), Gaps = 26/195 (13%)
Query: 1219 KVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEK 1278
K+ +Y++ F+GK +E T C V E F +V S+KV G W+ YE
Sbjct: 32 KITIYDQENFQGKRMEF-TSSCPNVSERS------------FDNVRSLKVESGAWIGYEH 78
Query: 1279 PGFTGHQYLLEEGEYRDWKAWGGYNG----ELQSLRPIL-GDFSNAHMIMYSEKNFGSKG 1333
F G Q++LE GEY W AW G N L S RPI + + M ++ ++NF G
Sbjct: 79 TSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKMTIFEKENF--IG 136
Query: 1334 SSIDVLGIVANLKETG-YGVKTQSINVLSGVWVAYENPDFTGEQYILD----KGFYTSFE 1388
++ +L+ G + + S+ + SG WV Y+ P + G QYIL+ G Y +
Sbjct: 137 RQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWR 196
Query: 1389 DWGGKNCKISSVQPI 1403
+W G + + S +Q I
Sbjct: 197 EW-GSHAQTSQIQSI 210
Score = 92.8 bits (229), Expect = 3e-18
Identities = 58/165 (35%), Positives = 80/165 (48%), Gaps = 26/165 (15%)
Query: 1158 SMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAY----IGSMRPLKMGGRKVE 1213
S+KV G W+ YE F G FILE GEYP W AY + S RP+ K
Sbjct: 65 SLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSANHK-- 122
Query: 1214 FPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIW 1273
+ K+ ++EK F G+ E+ S G E VGSMK+ G W
Sbjct: 123 ---ESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNE-----------VGSMKIQSGAW 168
Query: 1274 VAYEKPGFTGHQYLLE----EGEYRDWKAWGGY--NGELQSLRPI 1312
V Y+ PG+ G+QY+LE G+Y+ W+ WG + ++QS+R I
Sbjct: 169 VCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRI 213
Score = 84.3 bits (207), Expect = 9e-16
Identities = 47/177 (26%), Positives = 90/177 (50%), Gaps = 11/177 (6%)
Query: 1416 QIHLFSEPQFQGHSQSFEETTSQIDD-SF-STKSCRVSGGSWVVYDGENFTGNQYVLEEG 1473
+I ++ + FQG F + + + SF + +S +V G+W+ Y+ +F G Q++LE G
Sbjct: 32 KITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERG 91
Query: 1474 HYPCLSAMGCPPGATFKSLR----FIDVEFSEPTIILFEREDFKGKKIELNAETVNLRSL 1529
YP A + L E + +FE+E+F G++ E++ + +L+++
Sbjct: 92 EYPRWDAWSGSNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEISDDYPSLQAM 151
Query: 1530 G-FNTQIRSVQVIGGIWVTYEYGSYRGRQFLLS----PAEVPNWYEFSGCRQIGSLR 1581
G FN ++ S+++ G WV Y+Y YRG Q++L + +W E+ Q ++
Sbjct: 152 GWFNNEVGSMKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQ 208
Score = 69.3 bits (168), Expect = 3e-11
Identities = 55/199 (27%), Positives = 84/199 (42%), Gaps = 18/199 (9%)
Query: 1008 TLRGSVQNKLNPRPG-----KVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRG 1062
TL + + NP PG K+ IY + + K +E S + S S V +KV G
Sbjct: 12 TLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVESG 71
Query: 1063 CWILYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRV 1122
WI YE +F G LE GE W + E S +P+ +++
Sbjct: 72 AWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAY-HIERLMSFRPICSA-------NHKE 123
Query: 1123 SHIDLFTEPEGLGILSSYFDDTEEMQGFG-VMQKTCSMKVHWGTWLIYEEPGFQGVPFIL 1181
S + +F + +G DD +Q G + SMK+ G W+ Y+ PG++G +IL
Sbjct: 124 SKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQYIL 183
Query: 1182 E----PGEYPDLSFWDTEA 1196
E G+Y W + A
Sbjct: 184 ECDHHGGDYKHWREWGSHA 202
>gi|4758074 crystallin, beta B3 [Homo sapiens]
Length = 211
Score = 93.2 bits (230), Expect = 2e-18
Identities = 58/187 (31%), Positives = 91/187 (48%), Gaps = 16/187 (8%)
Query: 1219 KVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEK 1278
KV++YE F+GK EL S D L VGS++V G W+A+E
Sbjct: 25 KVILYELENFQGKRCELSAECPSLT------------DSL-LEKVGSIQVESGPWLAFES 71
Query: 1279 PGFTGHQYLLEEGEYRDWKAWGGY--NGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSI 1336
F G Q++LE+G+Y W AW + L SLRP+ D + + ++ F + I
Sbjct: 72 RAFRGEQFVLEKGDYPRWDAWSNSRDSDSLLSLRPLNIDSPHHKLHLFENPAFSGRKMEI 131
Query: 1337 DVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNCK 1396
V V +L G+ + S+ ++G WV YE P + G QY+ ++G Y + +W +
Sbjct: 132 -VDDDVPSLWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRHWNEWDASQPQ 190
Query: 1397 ISSVQPI 1403
+ SV+ I
Sbjct: 191 LQSVRRI 197
Score = 90.9 bits (224), Expect = 1e-17
Identities = 51/163 (31%), Positives = 80/163 (49%), Gaps = 19/163 (11%)
Query: 1152 VMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDT--EAAYIGSMRPLKMGG 1209
+++K S++V G WL +E F+G F+LE G+YP W ++ + S+RPL +
Sbjct: 52 LLEKVGSIQVESGPWLAFESRAFRGEQFVLEKGDYPRWDAWSNSRDSDSLLSLRPLNIDS 111
Query: 1210 RKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVL 1269
K+ ++E P F G+ +E+ + G + V S++ +
Sbjct: 112 ------PHHKLHLFENPAFSGRKMEIVDDDVPSLWAHGFQDR-----------VASVRAI 154
Query: 1270 RGIWVAYEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPI 1312
G WV YE PG+ G QY+ E GEYR W W +LQS+R I
Sbjct: 155 NGTWVGYEFPGYRGRQYVFERGEYRHWNEWDASQPQLQSVRRI 197
Score = 88.2 bits (217), Expect = 6e-17
Identities = 54/171 (31%), Positives = 88/171 (51%), Gaps = 5/171 (2%)
Query: 1416 QIHLFSEPQFQGHSQSFEETTSQIDDSFSTK--SCRVSGGSWVVYDGENFTGNQYVLEEG 1473
++ L+ FQG + DS K S +V G W+ ++ F G Q+VLE+G
Sbjct: 25 KVILYELENFQGKRCELSAECPSLTDSLLEKVGSIQVESGPWLAFESRAFRGEQFVLEKG 84
Query: 1474 HYPCLSAMGCPPGA-TFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETV-NLRSLGF 1531
YP A + + SLR ++++ + LFE F G+K+E+ + V +L + GF
Sbjct: 85 DYPRWDAWSNSRDSDSLLSLRPLNIDSPHHKLHLFENPAFSGRKMEIVDDDVPSLWAHGF 144
Query: 1532 NTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCR-QIGSLR 1581
++ SV+ I G WV YE+ YRGRQ++ E +W E+ + Q+ S+R
Sbjct: 145 QDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRHWNEWDASQPQLQSVR 195
Score = 65.1 bits (157), Expect = 6e-10
Identities = 47/185 (25%), Positives = 78/185 (42%), Gaps = 12/185 (6%)
Query: 1023 KVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLEEG 1082
KV++Y + K E+ ++ + L V I+V G W+ +E F G LE+G
Sbjct: 25 KVILYELENFQGKRCELSAECPSLTDSLLEKVGSIQVESGPWLAFESRAFRGEQFVLEKG 84
Query: 1083 ELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGI-LSSYF 1141
+ W + S +P+ I S H + LF P G +
Sbjct: 85 DYPRWDAWSNS---RDSDSLLSLRPLNIDSPHH--------KLHLFENPAFSGRKMEIVD 133
Query: 1142 DDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIGS 1201
DD + G + S++ GTW+ YE PG++G ++ E GEY + WD + S
Sbjct: 134 DDVPSLWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRHWNEWDASQPQLQS 193
Query: 1202 MRPLK 1206
+R ++
Sbjct: 194 VRRIR 198
>gi|16936542 crystallin, beta A2 [Homo sapiens]
Length = 197
Score = 90.1 bits (222), Expect = 2e-17
Identities = 54/173 (31%), Positives = 91/173 (52%), Gaps = 20/173 (11%)
Query: 1215 PTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWV 1274
P + ++++ F+G+ L + + GG LP V S+KV G+WV
Sbjct: 9 PAPASLTLWDEEDFQGRRCRLLSDCANVCERGG----------LP--RVRSVKVENGVWV 56
Query: 1275 AYEKPGFTGHQYLLEEGEYRDWKAWGG----YNGELQSLRPIL-GDFSNAHMIMYSEKNF 1329
A+E P F G Q++LE+G+Y W AW G + +L S RP+L + +++ + ++ NF
Sbjct: 57 AFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNF 116
Query: 1330 GSKGSSIDVLGIVANLKETGYGVK-TQSINVLSGVWVAYENPDFTGEQYILDK 1381
+G D++ +L G+ K S+ V SG WVAY+ P + G QY+L++
Sbjct: 117 --QGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLER 167
Score = 84.0 bits (206), Expect = 1e-15
Identities = 60/198 (30%), Positives = 94/198 (47%), Gaps = 26/198 (13%)
Query: 1125 IDLFTEPEGLGILSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPG 1184
+ L+ E + G D + G + + S+KV G W+ +E P FQG FILE G
Sbjct: 14 LTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKG 73
Query: 1185 EYPDLSFWDTEAAY----IGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMC 1240
+YP S W +++ + S RP+ D +V ++E F+G +L
Sbjct: 74 DYPRWSAWSGSSSHNSNQLLSFRPVLCANH-----NDSRVTLFEGDNFQGCKFDLVDDYP 128
Query: 1241 SFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLE----EGEYRDW 1296
S G +++ VGS+KV G WVAY+ PG+ G+QY+LE GE+ +
Sbjct: 129 SLPSMGWASKD-----------VGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTY 177
Query: 1297 KAWG--GYNGELQSLRPI 1312
G + G+LQS+R +
Sbjct: 178 GELGTQAHTGQLQSIRRV 195
Score = 79.3 bits (194), Expect = 3e-14
Identities = 52/165 (31%), Positives = 81/165 (49%), Gaps = 14/165 (8%)
Query: 1319 AHMIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYI 1378
A + ++ E++F +G +L AN+ E G + +S+ V +GVWVA+E PDF G+Q+I
Sbjct: 12 ASLTLWDEEDF--QGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFI 69
Query: 1379 LDKGFYTSFEDWGGKNC----KISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHS----Q 1430
L+KG Y + W G + ++ S +P+ + R + LF FQG
Sbjct: 70 LEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSR----VTLFEGDNFQGCKFDLVD 125
Query: 1431 SFEETTSQIDDSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGHY 1475
+ S S S +VS G+WV Y + G QYVLE +
Sbjct: 126 DYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRH 170
Score = 71.2 bits (173), Expect = 8e-12
Identities = 46/150 (30%), Positives = 78/150 (52%), Gaps = 8/150 (5%)
Query: 1419 LFSEPQFQGHSQSFEETTSQIDDSFS---TKSCRVSGGSWVVYDGENFTGNQYVLEEGHY 1475
L+ E FQG + + + +S +V G WV ++ +F G Q++LE+G Y
Sbjct: 16 LWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDY 75
Query: 1476 PCLSA-MGCPPGATFKSLRFIDV---EFSEPTIILFEREDFKGKKIELNAETVNLRSLGF 1531
P SA G + + L F V ++ + LFE ++F+G K +L + +L S+G+
Sbjct: 76 PRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGW 135
Query: 1532 -NTQIRSVQVIGGIWVTYEYGSYRGRQFLL 1560
+ + S++V G WV Y+Y YRG Q++L
Sbjct: 136 ASKDVGSLKVSSGAWVAYQYPGYRGYQYVL 165
Score = 65.1 bits (157), Expect = 6e-10
Identities = 43/166 (25%), Positives = 70/166 (42%), Gaps = 10/166 (6%)
Query: 1019 PRPGKVVIYSEPDVSEKCIEVFSDIQD-CSSWSLSPVILIKVVRGCWILYEQPNFEGHSI 1077
P P + ++ E D + + SD + C L V +KV G W+ +E P+F+G
Sbjct: 9 PAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQF 68
Query: 1078 PLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGIL 1137
LE+G+ W + S +PV+ ++ S + LF G
Sbjct: 69 ILEKGDYPRWSAWS-GSSSHNSNQLLSFRPVLCA-------NHNDSRVTLFEGDNFQGCK 120
Query: 1138 SSYFDDTEEMQGFGVMQKTC-SMKVHWGTWLIYEEPGFQGVPFILE 1182
DD + G K S+KV G W+ Y+ PG++G ++LE
Sbjct: 121 FDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLE 166
Score = 63.2 bits (152), Expect = 2e-09
Identities = 29/85 (34%), Positives = 51/85 (60%), Gaps = 5/85 (5%)
Query: 1503 TIILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSP 1562
++ L++ EDF+G++ L ++ N+ G ++RSV+V G+WV +EY ++G+QF+L
Sbjct: 13 SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72
Query: 1563 AEVPNWYEFSG-----CRQIGSLRP 1582
+ P W +SG Q+ S RP
Sbjct: 73 GDYPRWSAWSGSSSHNSNQLLSFRP 97
>gi|16936540 crystallin, beta A2 [Homo sapiens]
Length = 197
Score = 90.1 bits (222), Expect = 2e-17
Identities = 54/173 (31%), Positives = 91/173 (52%), Gaps = 20/173 (11%)
Query: 1215 PTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWV 1274
P + ++++ F+G+ L + + GG LP V S+KV G+WV
Sbjct: 9 PAPASLTLWDEEDFQGRRCRLLSDCANVCERGG----------LP--RVRSVKVENGVWV 56
Query: 1275 AYEKPGFTGHQYLLEEGEYRDWKAWGG----YNGELQSLRPIL-GDFSNAHMIMYSEKNF 1329
A+E P F G Q++LE+G+Y W AW G + +L S RP+L + +++ + ++ NF
Sbjct: 57 AFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNF 116
Query: 1330 GSKGSSIDVLGIVANLKETGYGVK-TQSINVLSGVWVAYENPDFTGEQYILDK 1381
+G D++ +L G+ K S+ V SG WVAY+ P + G QY+L++
Sbjct: 117 --QGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLER 167
Score = 84.0 bits (206), Expect = 1e-15
Identities = 60/198 (30%), Positives = 94/198 (47%), Gaps = 26/198 (13%)
Query: 1125 IDLFTEPEGLGILSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPG 1184
+ L+ E + G D + G + + S+KV G W+ +E P FQG FILE G
Sbjct: 14 LTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKG 73
Query: 1185 EYPDLSFWDTEAAY----IGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMC 1240
+YP S W +++ + S RP+ D +V ++E F+G +L
Sbjct: 74 DYPRWSAWSGSSSHNSNQLLSFRPVLCANH-----NDSRVTLFEGDNFQGCKFDLVDDYP 128
Query: 1241 SFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLE----EGEYRDW 1296
S G +++ VGS+KV G WVAY+ PG+ G+QY+LE GE+ +
Sbjct: 129 SLPSMGWASKD-----------VGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTY 177
Query: 1297 KAWG--GYNGELQSLRPI 1312
G + G+LQS+R +
Sbjct: 178 GELGTQAHTGQLQSIRRV 195
Score = 79.3 bits (194), Expect = 3e-14
Identities = 52/165 (31%), Positives = 81/165 (49%), Gaps = 14/165 (8%)
Query: 1319 AHMIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYI 1378
A + ++ E++F +G +L AN+ E G + +S+ V +GVWVA+E PDF G+Q+I
Sbjct: 12 ASLTLWDEEDF--QGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFI 69
Query: 1379 LDKGFYTSFEDWGGKNC----KISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHS----Q 1430
L+KG Y + W G + ++ S +P+ + R + LF FQG
Sbjct: 70 LEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSR----VTLFEGDNFQGCKFDLVD 125
Query: 1431 SFEETTSQIDDSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGHY 1475
+ S S S +VS G+WV Y + G QYVLE +
Sbjct: 126 DYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRH 170
Score = 71.2 bits (173), Expect = 8e-12
Identities = 46/150 (30%), Positives = 78/150 (52%), Gaps = 8/150 (5%)
Query: 1419 LFSEPQFQGHSQSFEETTSQIDDSFS---TKSCRVSGGSWVVYDGENFTGNQYVLEEGHY 1475
L+ E FQG + + + +S +V G WV ++ +F G Q++LE+G Y
Sbjct: 16 LWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDY 75
Query: 1476 PCLSA-MGCPPGATFKSLRFIDV---EFSEPTIILFEREDFKGKKIELNAETVNLRSLGF 1531
P SA G + + L F V ++ + LFE ++F+G K +L + +L S+G+
Sbjct: 76 PRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGW 135
Query: 1532 -NTQIRSVQVIGGIWVTYEYGSYRGRQFLL 1560
+ + S++V G WV Y+Y YRG Q++L
Sbjct: 136 ASKDVGSLKVSSGAWVAYQYPGYRGYQYVL 165
Score = 65.1 bits (157), Expect = 6e-10
Identities = 43/166 (25%), Positives = 70/166 (42%), Gaps = 10/166 (6%)
Query: 1019 PRPGKVVIYSEPDVSEKCIEVFSDIQD-CSSWSLSPVILIKVVRGCWILYEQPNFEGHSI 1077
P P + ++ E D + + SD + C L V +KV G W+ +E P+F+G
Sbjct: 9 PAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQF 68
Query: 1078 PLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGIL 1137
LE+G+ W + S +PV+ ++ S + LF G
Sbjct: 69 ILEKGDYPRWSAWS-GSSSHNSNQLLSFRPVLCA-------NHNDSRVTLFEGDNFQGCK 120
Query: 1138 SSYFDDTEEMQGFGVMQKTC-SMKVHWGTWLIYEEPGFQGVPFILE 1182
DD + G K S+KV G W+ Y+ PG++G ++LE
Sbjct: 121 FDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLE 166
Score = 63.2 bits (152), Expect = 2e-09
Identities = 29/85 (34%), Positives = 51/85 (60%), Gaps = 5/85 (5%)
Query: 1503 TIILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSP 1562
++ L++ EDF+G++ L ++ N+ G ++RSV+V G+WV +EY ++G+QF+L
Sbjct: 13 SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72
Query: 1563 AEVPNWYEFSG-----CRQIGSLRP 1582
+ P W +SG Q+ S RP
Sbjct: 73 GDYPRWSAWSGSSSHNSNQLLSFRP 97
>gi|7019357 crystallin, beta A2 [Homo sapiens]
Length = 197
Score = 90.1 bits (222), Expect = 2e-17
Identities = 54/173 (31%), Positives = 91/173 (52%), Gaps = 20/173 (11%)
Query: 1215 PTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWV 1274
P + ++++ F+G+ L + + GG LP V S+KV G+WV
Sbjct: 9 PAPASLTLWDEEDFQGRRCRLLSDCANVCERGG----------LP--RVRSVKVENGVWV 56
Query: 1275 AYEKPGFTGHQYLLEEGEYRDWKAWGG----YNGELQSLRPIL-GDFSNAHMIMYSEKNF 1329
A+E P F G Q++LE+G+Y W AW G + +L S RP+L + +++ + ++ NF
Sbjct: 57 AFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNF 116
Query: 1330 GSKGSSIDVLGIVANLKETGYGVK-TQSINVLSGVWVAYENPDFTGEQYILDK 1381
+G D++ +L G+ K S+ V SG WVAY+ P + G QY+L++
Sbjct: 117 --QGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLER 167
Score = 84.0 bits (206), Expect = 1e-15
Identities = 60/198 (30%), Positives = 94/198 (47%), Gaps = 26/198 (13%)
Query: 1125 IDLFTEPEGLGILSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPG 1184
+ L+ E + G D + G + + S+KV G W+ +E P FQG FILE G
Sbjct: 14 LTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKG 73
Query: 1185 EYPDLSFWDTEAAY----IGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMC 1240
+YP S W +++ + S RP+ D +V ++E F+G +L
Sbjct: 74 DYPRWSAWSGSSSHNSNQLLSFRPVLCANH-----NDSRVTLFEGDNFQGCKFDLVDDYP 128
Query: 1241 SFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLE----EGEYRDW 1296
S G +++ VGS+KV G WVAY+ PG+ G+QY+LE GE+ +
Sbjct: 129 SLPSMGWASKD-----------VGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTY 177
Query: 1297 KAWG--GYNGELQSLRPI 1312
G + G+LQS+R +
Sbjct: 178 GELGTQAHTGQLQSIRRV 195
Score = 79.3 bits (194), Expect = 3e-14
Identities = 52/165 (31%), Positives = 81/165 (49%), Gaps = 14/165 (8%)
Query: 1319 AHMIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYI 1378
A + ++ E++F +G +L AN+ E G + +S+ V +GVWVA+E PDF G+Q+I
Sbjct: 12 ASLTLWDEEDF--QGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFI 69
Query: 1379 LDKGFYTSFEDWGGKNC----KISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHS----Q 1430
L+KG Y + W G + ++ S +P+ + R + LF FQG
Sbjct: 70 LEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSR----VTLFEGDNFQGCKFDLVD 125
Query: 1431 SFEETTSQIDDSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGHY 1475
+ S S S +VS G+WV Y + G QYVLE +
Sbjct: 126 DYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRH 170
Score = 71.2 bits (173), Expect = 8e-12
Identities = 46/150 (30%), Positives = 78/150 (52%), Gaps = 8/150 (5%)
Query: 1419 LFSEPQFQGHSQSFEETTSQIDDSFS---TKSCRVSGGSWVVYDGENFTGNQYVLEEGHY 1475
L+ E FQG + + + +S +V G WV ++ +F G Q++LE+G Y
Sbjct: 16 LWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDY 75
Query: 1476 PCLSA-MGCPPGATFKSLRFIDV---EFSEPTIILFEREDFKGKKIELNAETVNLRSLGF 1531
P SA G + + L F V ++ + LFE ++F+G K +L + +L S+G+
Sbjct: 76 PRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGW 135
Query: 1532 -NTQIRSVQVIGGIWVTYEYGSYRGRQFLL 1560
+ + S++V G WV Y+Y YRG Q++L
Sbjct: 136 ASKDVGSLKVSSGAWVAYQYPGYRGYQYVL 165
Score = 65.1 bits (157), Expect = 6e-10
Identities = 43/166 (25%), Positives = 70/166 (42%), Gaps = 10/166 (6%)
Query: 1019 PRPGKVVIYSEPDVSEKCIEVFSDIQD-CSSWSLSPVILIKVVRGCWILYEQPNFEGHSI 1077
P P + ++ E D + + SD + C L V +KV G W+ +E P+F+G
Sbjct: 9 PAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQF 68
Query: 1078 PLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGIL 1137
LE+G+ W + S +PV+ ++ S + LF G
Sbjct: 69 ILEKGDYPRWSAWS-GSSSHNSNQLLSFRPVLCA-------NHNDSRVTLFEGDNFQGCK 120
Query: 1138 SSYFDDTEEMQGFGVMQKTC-SMKVHWGTWLIYEEPGFQGVPFILE 1182
DD + G K S+KV G W+ Y+ PG++G ++LE
Sbjct: 121 FDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLE 166
Score = 63.2 bits (152), Expect = 2e-09
Identities = 29/85 (34%), Positives = 51/85 (60%), Gaps = 5/85 (5%)
Query: 1503 TIILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSP 1562
++ L++ EDF+G++ L ++ N+ G ++RSV+V G+WV +EY ++G+QF+L
Sbjct: 13 SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72
Query: 1563 AEVPNWYEFSG-----CRQIGSLRP 1582
+ P W +SG Q+ S RP
Sbjct: 73 GDYPRWSAWSGSSSHNSNQLLSFRP 97
>gi|13377002 crystallin, gamma D [Homo sapiens]
Length = 174
Score = 88.6 bits (218), Expect = 5e-17
Identities = 58/190 (30%), Positives = 95/190 (50%), Gaps = 27/190 (14%)
Query: 1219 KVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDH---LPFTS-VGSMKVLRGIWV 1274
K+ +YE F+G+ E CS DH P+ S S +V G W+
Sbjct: 3 KITLYEDRGFQGRHYE-----CS-------------SDHPNLQPYLSRCNSARVDSGCWM 44
Query: 1275 AYEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMI-MYSEKNFGSKG 1333
YE+P ++G QY L G+Y D + W G + ++S R I S +H I +Y +++ +G
Sbjct: 45 LYEQPNYSGLQYFLRRGDYADHQQWMGLSDSVRSCRLI--PHSGSHRIRLYEREDY--RG 100
Query: 1334 SSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGK 1393
I+ + L++ + S+NVL G WV YE ++ G QY+L G Y ++DWG
Sbjct: 101 QMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGAT 160
Query: 1394 NCKISSVQPI 1403
N ++ S++ +
Sbjct: 161 NARVGSLRRV 170
Score = 85.1 bits (209), Expect = 5e-16
Identities = 50/160 (31%), Positives = 78/160 (48%), Gaps = 20/160 (12%)
Query: 1158 SMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIGSMRPLKMGGRKVEFPTD 1217
S +V G W++YE+P + G+ + L G+Y D W + + S R + G
Sbjct: 35 SARVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWMGLSDSVRSCRLIPHSGSH------ 88
Query: 1218 PKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYE 1277
++ +YE+ + G+ +E T CS + D F + S+ VL G WV YE
Sbjct: 89 -RIRLYEREDYRGQMIEF-TEDCSCLQ-----------DRFRFNEIHSLNVLEGSWVLYE 135
Query: 1278 KPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFS 1317
+ G QYLL G+YR ++ WG N + SLR ++ DFS
Sbjct: 136 LSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVI-DFS 174
Score = 80.9 bits (198), Expect = 1e-14
Identities = 55/169 (32%), Positives = 82/169 (48%), Gaps = 6/169 (3%)
Query: 1416 QIHLFSEPQFQGHSQSFEETTSQIDDSFST-KSCRVSGGSWVVYDGENFTGNQYVLEEGH 1474
+I L+ + FQG + S S RV G W++Y+ N++G QY L G
Sbjct: 3 KITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRRGD 62
Query: 1475 YPCLSA-MGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNLRSLGFNT 1533
Y MG +S R I S I L+ERED++G+ IE + L+
Sbjct: 63 YADHQQWMGLSDSV--RSCRLIPHSGSH-RIRLYEREDYRGQMIEFTEDCSCLQDRFRFN 119
Query: 1534 QIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCR-QIGSLR 1581
+I S+ V+ G WV YE +YRGRQ+LL P + + ++ ++GSLR
Sbjct: 120 EIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLR 168
Score = 62.8 bits (151), Expect = 3e-09
Identities = 49/184 (26%), Positives = 81/184 (44%), Gaps = 19/184 (10%)
Query: 1022 GKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLEE 1081
GK+ +Y + + E SD + + LS +V GCW+LYEQPN+ G L
Sbjct: 2 GKITLYEDRGFQGRHYECSSDHPNLQPY-LSRCNSARVDSGCWMLYEQPNYSGLQYFLRR 60
Query: 1082 GELELSGLW-GIEDILERHEEAESDKPVVIGSIRHVVQDYRVSH-IDLFTEPEGLGILSS 1139
G+ W G+ D + S R + + SH I L+ + G +
Sbjct: 61 GDYADHQQWMGLSDSVR--------------SCRLI--PHSGSHRIRLYEREDYRGQMIE 104
Query: 1140 YFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYI 1199
+ +D +Q + S+ V G+W++YE ++G ++L PG+Y W A +
Sbjct: 105 FTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARV 164
Query: 1200 GSMR 1203
GS+R
Sbjct: 165 GSLR 168
>gi|10518338 crystallin, gamma C [Homo sapiens]
Length = 174
Score = 86.3 bits (212), Expect = 2e-16
Identities = 58/172 (33%), Positives = 86/172 (50%), Gaps = 6/172 (3%)
Query: 1416 QIHLFSEPQFQGHSQSFEETTSQIDDSFST-KSCRVSGGSWVVYDGENFTGNQYVLEEGH 1474
+I + + FQG S + FS S RV G W++Y+ N+ G QY+L G
Sbjct: 3 KITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRRGE 62
Query: 1475 YPCLSA-MGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNLRSLGFNT 1533
YP MG + +S I S + L+ERED KG +EL+ + +++ +
Sbjct: 63 YPDYQQWMGLSD--SIRSCCLIPQTVSH-RLRLYEREDHKGLMMELSEDCPSIQDRFHLS 119
Query: 1534 QIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGC-RQIGSLRPFV 1584
+IRS+ V+ G WV YE +YRGRQ+LL P E ++ + GSLR V
Sbjct: 120 EIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVV 171
Score = 85.9 bits (211), Expect = 3e-16
Identities = 52/185 (28%), Positives = 89/185 (48%), Gaps = 17/185 (9%)
Query: 1219 KVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEK 1278
K+ YE F+G+ E T + F+ S++V G W+ YE+
Sbjct: 3 KITFYEDRAFQGRSYETTTDCPNLQPY--------------FSRCNSIRVESGCWMLYER 48
Query: 1279 PGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDV 1338
P + G QYLL GEY D++ W G + ++S I S H + E+ KG +++
Sbjct: 49 PNYQGQQYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVS--HRLRLYERE-DHKGLMMEL 105
Query: 1339 LGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNCKIS 1398
++++ + + +S++VL G WV YE P++ G QY+L Y +DWG + K
Sbjct: 106 SEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAG 165
Query: 1399 SVQPI 1403
S++ +
Sbjct: 166 SLRRV 170
Score = 79.3 bits (194), Expect = 3e-14
Identities = 48/156 (30%), Positives = 73/156 (46%), Gaps = 19/156 (12%)
Query: 1158 SMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIGSMRPLKMGGRKVEFPTD 1217
S++V G W++YE P +QG ++L GEYPD W S+R + + V
Sbjct: 35 SIRVESGCWMLYERPNYQGQQYLLRRGEYPDYQQW---MGLSDSIRSCCLIPQTVSH--- 88
Query: 1218 PKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYE 1277
++ +YE+ +G +EL S D + + S+ VL G WV YE
Sbjct: 89 -RLRLYEREDHKGLMMELSEDCPSI------------QDRFHLSEIRSLHVLEGCWVLYE 135
Query: 1278 KPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPIL 1313
P + G QYLL EYR + WG + + SLR ++
Sbjct: 136 LPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVV 171
Score = 67.0 bits (162), Expect = 1e-10
Identities = 50/185 (27%), Positives = 80/185 (43%), Gaps = 21/185 (11%)
Query: 1022 GKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLEE 1081
GK+ Y + + E +D + + S I+V GCW+LYE+PN++G L
Sbjct: 2 GKITFYEDRAFQGRSYETTTDCPNLQPY-FSRCNSIRVESGCWMLYERPNYQGQQYLLRR 60
Query: 1082 GELELSGLW-GIEDILERHEEAESDKPVVIGSIRHV-VQDYRVSH-IDLFTEPEGLGILS 1138
GE W G+ D SIR + VSH + L+ + G++
Sbjct: 61 GEYPDYQQWMGLSD-----------------SIRSCCLIPQTVSHRLRLYEREDHKGLMM 103
Query: 1139 SYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEAAY 1198
+D +Q + + S+ V G W++YE P ++G ++L P EY W A
Sbjct: 104 ELSEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAK 163
Query: 1199 IGSMR 1203
GS+R
Sbjct: 164 AGSLR 168
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 77.0 bits (188), Expect = 1e-13
Identities = 202/963 (20%), Positives = 328/963 (34%), Gaps = 143/963 (14%)
Query: 5 SSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRA 64
+S ++G+ +S+ +D+E AA+ A+ + + + A++ +SPR
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAK--ALLQAKASGKTSQVGAASAPAKESPRK 384
Query: 65 ALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASG 124
+A +P K P G+ + Q S ++ + ++A + AP
Sbjct: 385 G------AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 125 PRAPAKESPPKRVPDPSPVTKGTAA-------------ESGEEA-----ARAIPRELPVK 166
APAKESP K P G AA S EE+ A A VK
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 167 SSSLLPEIKPEHK---------RGPLPNHFNG----RAEGGRSRELGRAAGAPGASDADG 213
P++KP GP+P G A+ G+ E ++ + +DG
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 214 -----LKPRNHFGVGRSTVTTKVTLPAK-------PKHVELNLKTP--------KNLDSL 253
+ P +G + PAK P V++ + P ++ DS
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 618
Query: 254 GNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLAK 313
+E P + + A KI +T + P+ T NT AS+K R +
Sbjct: 619 DSEEAPAAMTAAQAKPALKI-----PQTKACPKKT------NTTASAKVAPVRVGTQAPR 667
Query: 314 KAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEI--LPATRGMNGDSSENQALGP 371
KA P P E + ++ + SEEE L T G QA
Sbjct: 668 KAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG--------QAKSV 718
Query: 372 QPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIP 431
KA G L + A L + + + + DS+S E+ ++ A P
Sbjct: 719 GKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778
Query: 432 TTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPC 491
V T A P + S S+PG ++ +A A P V+ P+ + P
Sbjct: 779 AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK--VKPPVRN-PQ 835
Query: 492 TDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRS 551
++ P S + K +T P + S E SE + L QV+
Sbjct: 836 NSTVLARG------PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK- 888
Query: 552 FVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTA 611
P T + + + P R+ PT S A + +E S
Sbjct: 889 ---PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP--SAAQAGKQDDSGSSSEESDSDG 943
Query: 612 EL-AAKSGPQVI-----------PPASEKTLPIQAQSQGSRTPLMAESSPTNSPSS---- 655
E AA + QVI PA P QAQ+ + A S S SS
Sbjct: 944 EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESED 1003
Query: 656 -----GNHLATPQRPDQTVTNGQDSP-----ASLLNISAGSDDS-VFDSSSDMEKFTEII 704
TP VT P AS+ S+ + S + D T++
Sbjct: 1004 EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVS 1063
Query: 705 KQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMS 764
K+ + +P+ + ++ A A PP+ D V T P S
Sbjct: 1064 KK--NPASLPLTQAALKVLAQKASE-AQPPVARTQPSSGVDSAVGTL---------PATS 1111
Query: 765 PALHLMQNLDTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNG-- 822
P +Q T +PK +Q+ ++ +S+ E + + + +
Sbjct: 1112 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1171
Query: 823 -GIKRSRLEKSALFSSLLSSLPQDKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTTE 881
G SR E L + +D + +PS + ++ T T N SQ+S + P +
Sbjct: 1172 LGPTPSRTE--TLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPAN---SQASKATPKLD 1226
Query: 882 GAP 884
+P
Sbjct: 1227 SSP 1229
Score = 38.5 bits (88), Expect = 0.057
Identities = 144/743 (19%), Positives = 236/743 (31%), Gaps = 112/743 (15%)
Query: 16 SQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVASAAS 75
S TD G + P + A AA A KV + GG A
Sbjct: 206 SSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP----APGKVGDVTPQVKGGALPPAK 261
Query: 76 PESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRAPAKESPPK 135
KP ++ G + P S K + + A AP P A +PP
Sbjct: 262 RAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPG 321
Query: 136 RVPDPSPVTKGTAAESGEEA--------------------ARAIPRELPVKSSSLLPEIK 175
+ + TK E E+ A+A + V ++S +
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKES 381
Query: 176 PEHKRGPLPNHFNG----RAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKV 231
P P P G +A+ G+ E +++ SD++ P G++
Sbjct: 382 PRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE--ESDSEEEAPAQAKPSGKAPQVRAA 439
Query: 232 TLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIR 291
+ PAK + P + P + V G E+ R++S +D
Sbjct: 440 SAPAKESPRKGAAPAPP------RKTGPAAAQVQVGKQE------EDSRSSSEESDSDRE 487
Query: 292 GQRNTPASSKTFVGRAKLNLAKKAKEMEQ----------PEKKVMPNSPQNGVLVKETAI 341
A+ +G++ K A M P KV P +P V E
Sbjct: 488 ALAAMNAAQVKPLGKSP--QVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 545
Query: 342 ETKVTVSEEEI---LPATRGMNGDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIP 398
E+ S + +P + S L +P AG PVA +
Sbjct: 546 ESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG----PVAVQVKA 601
Query: 399 VK--DHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLP----PTAMPKPQHTFS 452
K D+ +E S++ADS+ A+ TK P TA K
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 453 DSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNN 512
+Q+P ++ S + S+PA + P D SE S
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGG----------TQRPAEDSSSSEE--------SDSEE 703
Query: 513 EKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVI----- 567
EK L G+ ++VG +QV++ +PV+ + + +
Sbjct: 704 EKTGLAVTVGQA----------KSVGKG------LQVKAASVPVKGSLGQGTAPVLPGKT 747
Query: 568 -PESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPAS 626
P ++V+ + S+E E S + A P + + + A AA P S
Sbjct: 748 GPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTIS 807
Query: 627 EKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAG- 685
+ A +Q + P +P + LA R +V + + A+ G
Sbjct: 808 APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLA---RGPASVPSVGKAVATAAQAQTGP 864
Query: 686 -SDDSVFDSSSDMEKFTEIIKQM 707
D + SD E+ E + Q+
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQV 887
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 77.0 bits (188), Expect = 1e-13
Identities = 202/963 (20%), Positives = 328/963 (34%), Gaps = 143/963 (14%)
Query: 5 SSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRA 64
+S ++G+ +S+ +D+E AA+ A+ + + + A++ +SPR
Sbjct: 250 ASQTKAGKPEEDSESSSEESSDSEEETPAAK--ALLQAKASGKTSQVGAASAPAKESPRK 307
Query: 65 ALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASG 124
+A +P K P G+ + Q S ++ + ++A + AP
Sbjct: 308 G------AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 361
Query: 125 PRAPAKESPPKRVPDPSPVTKGTAA-------------ESGEEA-----ARAIPRELPVK 166
APAKESP K P G AA S EE+ A A VK
Sbjct: 362 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 421
Query: 167 SSSLLPEIKPEHK---------RGPLPNHFNG----RAEGGRSRELGRAAGAPGASDADG 213
P++KP GP+P G A+ G+ E ++ + +DG
Sbjct: 422 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 481
Query: 214 -----LKPRNHFGVGRSTVTTKVTLPAK-------PKHVELNLKTP--------KNLDSL 253
+ P +G + PAK P V++ + P ++ DS
Sbjct: 482 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 541
Query: 254 GNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLAK 313
+E P + + A KI +T + P+ T NT AS+K R +
Sbjct: 542 DSEEAPAAMTAAQAKPALKI-----PQTKACPKKT------NTTASAKVAPVRVGTQAPR 590
Query: 314 KAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEI--LPATRGMNGDSSENQALGP 371
KA P P E + ++ + SEEE L T G QA
Sbjct: 591 KAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG--------QAKSV 641
Query: 372 QPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIP 431
KA G L + A L + + + + DS+S E+ ++ A P
Sbjct: 642 GKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 701
Query: 432 TTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPC 491
V T A P + S S+PG ++ +A A P V+ P+ + P
Sbjct: 702 AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK--VKPPVRN-PQ 758
Query: 492 TDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRS 551
++ P S + K +T P + S E SE + L QV+
Sbjct: 759 NSTVLARG------PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK- 811
Query: 552 FVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTA 611
P T + + + P R+ PT S A + +E S
Sbjct: 812 ---PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP--SAAQAGKQDDSGSSSEESDSDG 866
Query: 612 EL-AAKSGPQVI-----------PPASEKTLPIQAQSQGSRTPLMAESSPTNSPSS---- 655
E AA + QVI PA P QAQ+ + A S S SS
Sbjct: 867 EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESED 926
Query: 656 -----GNHLATPQRPDQTVTNGQDSP-----ASLLNISAGSDDS-VFDSSSDMEKFTEII 704
TP VT P AS+ S+ + S + D T++
Sbjct: 927 EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVS 986
Query: 705 KQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMS 764
K+ + +P+ + ++ A A PP+ D V T P S
Sbjct: 987 KK--NPASLPLTQAALKVLAQKASE-AQPPVARTQPSSGVDSAVGTL---------PATS 1034
Query: 765 PALHLMQNLDTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNG-- 822
P +Q T +PK +Q+ ++ +S+ E + + + +
Sbjct: 1035 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1094
Query: 823 -GIKRSRLEKSALFSSLLSSLPQDKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTTE 881
G SR E L + +D + +PS + ++ T T N SQ+S + P +
Sbjct: 1095 LGPTPSRTE--TLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPAN---SQASKATPKLD 1149
Query: 882 GAP 884
+P
Sbjct: 1150 SSP 1152
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 76.6 bits (187), Expect = 2e-13
Identities = 202/964 (20%), Positives = 328/964 (34%), Gaps = 144/964 (14%)
Query: 5 SSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRA 64
+S ++G+ +S+ +D+E AA+ A+ + + + A++ +SPR
Sbjct: 250 ASQTKAGKPEEDSESSSEESSDSEEETPAAK--ALLQAKASGKTSQVGAASAPAKESPRK 307
Query: 65 ALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASG 124
+A +P K P G+ + Q S ++ + ++A + AP
Sbjct: 308 G------AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 361
Query: 125 PRAPAKESPPKRVPDPSPVTKGTAA-------------ESGEEA-----ARAIPRELPVK 166
APAKESP K P G AA S EE+ A A VK
Sbjct: 362 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 421
Query: 167 SSSLLPEIKPEHK---------RGPLPNHFNG----RAEGGRSRELGRAAGAPGASDADG 213
P++KP GP+P G A+ G+ E ++ + +DG
Sbjct: 422 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 481
Query: 214 -----LKPRNHFGVGRSTVTTKVTLPAK-------PKHVELNLKTP--------KNLDSL 253
+ P +G + PAK P V++ + P ++ DS
Sbjct: 482 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 541
Query: 254 GNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLAK 313
+E P + + A KI +T + P+ T NT AS+K R +
Sbjct: 542 DSEEAPAAMTAAQAKPALKI-----PQTKACPKKT------NTTASAKVAPVRVGTQAPR 590
Query: 314 KAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEI--LPATRGMNGDSSENQALGP 371
KA P P E + ++ + SEEE L T G QA
Sbjct: 591 KAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG--------QAKSV 641
Query: 372 QPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIP 431
KA G L + A L + + + + DS+S E+ ++ A P
Sbjct: 642 GKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 701
Query: 432 TTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPC 491
V T A P + S S+PG ++ +A A P V+ P+ + P
Sbjct: 702 AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK--VKPPVRN-PQ 758
Query: 492 TDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRS 551
++ P S + K +T P + S E SE + L QV+
Sbjct: 759 NSTVLARG------PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK- 811
Query: 552 FVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTA 611
P T + + + P R+ PT S A + +E S
Sbjct: 812 ---PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP--SAAQAGKQDDSGSSSEESDSDG 866
Query: 612 EL-AAKSGPQVI-----------PPASEKTLPIQAQSQGSRTPLMAESSPTNSPSS---- 655
E AA + QVI PA P QAQ+ + A S S SS
Sbjct: 867 EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESED 926
Query: 656 -----GNHLATPQRPDQTVTNGQDSP-----ASLLNISAGSDDS-VFDSSSDMEKFTEII 704
TP VT P AS+ S+ + S + D T++
Sbjct: 927 EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVS 986
Query: 705 KQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMS 764
K+ + +P+ + ++ A A PP+ D V T P S
Sbjct: 987 KK--NPASLPLTQAALKVLAQKASE-AQPPVARTQPSSGVDSAVGTL---------PATS 1034
Query: 765 PALHLMQNLDTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNG-- 822
P +Q T +PK +Q+ ++ +S+ E + + + +
Sbjct: 1035 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1094
Query: 823 --GIKRSRLEKSALFSSLLSSLPQDKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTT 880
G SR E L + +D + +PS + ++ T T N SQ+S + P
Sbjct: 1095 LVGPTPSRTE--TLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPAN---SQASKATPKL 1149
Query: 881 EGAP 884
+ +P
Sbjct: 1150 DSSP 1153
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 71.6 bits (174), Expect = 6e-12
Identities = 173/783 (22%), Positives = 265/783 (33%), Gaps = 119/783 (15%)
Query: 5 SSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRA 64
+S ++G+ +S+ +D+E AA+ A+ + + + A++ +SPR
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAK--ALLQAKASGKTSQVGAASAPAKESPRK 384
Query: 65 ALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASG 124
+A +P K P G+ + Q S ++ + ++A + AP
Sbjct: 385 G------AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 125 PRAPAKESPPKRVPDPSPVTKGTAA-------------ESGEEA-----ARAIPRELPVK 166
APAKESP K P G AA S EE+ A A VK
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 167 SSSLLPEIKPEHK---------RGPLPNHFNG----RAEGGRSRELGRAAGAPGASDADG 213
P++KP GP+P G A+ G+ E ++ + +DG
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 214 -----LKPRNHFGVGRSTVTTKVTLPAK-------PKHVELNLKTP--------KNLDSL 253
+ P +G + PAK P V++ + P ++ DS
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 618
Query: 254 GNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLAK 313
+E P + + A KI +T + P+ T NT AS+K R +
Sbjct: 619 DSEEAPAAMTAAQAKPALKI-----PQTKACPKKT------NTTASAKVAPVRVGTQAPR 667
Query: 314 KAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEI--LPATRGMNGDSSENQALGP 371
KA P P E + ++ + SEEE L T G QA
Sbjct: 668 KAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG--------QAKSV 718
Query: 372 QPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIP 431
KA G L + A L + + + + DS+S E+ ++ A P
Sbjct: 719 GKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778
Query: 432 TTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPC 491
V T A P + S S+PG ++ +A A P V+ P+ + P
Sbjct: 779 AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK--VKPPVRN-PQ 835
Query: 492 TDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRS 551
++ P S + K +T P + S E SE + L QV+
Sbjct: 836 NSTVLARG------PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK- 888
Query: 552 FVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTA 611
P T + + + P R+ PT S A + +E S
Sbjct: 889 ---PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP--SAAQAGKQDDSGSSSEESDSDG 943
Query: 612 EL-AAKSGPQVI-----------PPASEKTLPIQAQSQGSRTPLMAESSPTNSPSS---- 655
E AA + QVI PA P QAQ+ + A S S SS
Sbjct: 944 EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESED 1003
Query: 656 -----GNHLATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSS--SDMEKFTEIIKQMD 708
TP VT P S S +SS SD +K Q+D
Sbjct: 1004 EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVD 1063
Query: 709 SAV 711
SAV
Sbjct: 1064 SAV 1066
Score = 38.5 bits (88), Expect = 0.057
Identities = 144/743 (19%), Positives = 236/743 (31%), Gaps = 112/743 (15%)
Query: 16 SQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVASAAS 75
S TD G + P + A AA A KV + GG A
Sbjct: 206 SSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP----APGKVGDVTPQVKGGALPPAK 261
Query: 76 PESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRAPAKESPPK 135
KP ++ G + P S K + + A AP P A +PP
Sbjct: 262 RAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPG 321
Query: 136 RVPDPSPVTKGTAAESGEEA--------------------ARAIPRELPVKSSSLLPEIK 175
+ + TK E E+ A+A + V ++S +
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKES 381
Query: 176 PEHKRGPLPNHFNG----RAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKV 231
P P P G +A+ G+ E +++ SD++ P G++
Sbjct: 382 PRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE--ESDSEEEAPAQAKPSGKAPQVRAA 439
Query: 232 TLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIR 291
+ PAK + P + P + V G E+ R++S +D
Sbjct: 440 SAPAKESPRKGAAPAPP------RKTGPAAAQVQVGKQE------EDSRSSSEESDSDRE 487
Query: 292 GQRNTPASSKTFVGRAKLNLAKKAKEMEQ----------PEKKVMPNSPQNGVLVKETAI 341
A+ +G++ K A M P KV P +P V E
Sbjct: 488 ALAAMNAAQVKPLGKSP--QVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 545
Query: 342 ETKVTVSEEEI---LPATRGMNGDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIP 398
E+ S + +P + S L +P AG PVA +
Sbjct: 546 ESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG----PVAVQVKA 601
Query: 399 VK--DHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLP----PTAMPKPQHTFS 452
K D+ +E S++ADS+ A+ TK P TA K
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 453 DSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNN 512
+Q+P ++ S + S+PA + P D SE S
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGG----------TQRPAEDSSSSEE--------SDSEE 703
Query: 513 EKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVI----- 567
EK L G+ ++VG +QV++ +PV+ + + +
Sbjct: 704 EKTGLAVTVGQA----------KSVGKG------LQVKAASVPVKGSLGQGTAPVLPGKT 747
Query: 568 -PESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPAS 626
P ++V+ + S+E E S + A P + + + A AA P S
Sbjct: 748 GPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTIS 807
Query: 627 EKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAG- 685
+ A +Q + P +P + LA R +V + + A+ G
Sbjct: 808 APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLA---RGPASVPSVGKAVATAAQAQTGP 864
Query: 686 -SDDSVFDSSSDMEKFTEIIKQM 707
D + SD E+ E + Q+
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQV 887
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 71.6 bits (174), Expect = 6e-12
Identities = 173/783 (22%), Positives = 265/783 (33%), Gaps = 119/783 (15%)
Query: 5 SSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRA 64
+S ++G+ +S+ +D+E AA+ A+ + + + A++ +SPR
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAK--ALLQAKASGKTSQVGAASAPAKESPRK 384
Query: 65 ALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASG 124
+A +P K P G+ + Q S ++ + ++A + AP
Sbjct: 385 G------AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 125 PRAPAKESPPKRVPDPSPVTKGTAA-------------ESGEEA-----ARAIPRELPVK 166
APAKESP K P G AA S EE+ A A VK
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 167 SSSLLPEIKPEHK---------RGPLPNHFNG----RAEGGRSRELGRAAGAPGASDADG 213
P++KP GP+P G A+ G+ E ++ + +DG
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 214 -----LKPRNHFGVGRSTVTTKVTLPAK-------PKHVELNLKTP--------KNLDSL 253
+ P +G + PAK P V++ + P ++ DS
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 618
Query: 254 GNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLAK 313
+E P + + A KI +T + P+ T NT AS+K R +
Sbjct: 619 DSEEAPAAMTAAQAKPALKI-----PQTKACPKKT------NTTASAKVAPVRVGTQAPR 667
Query: 314 KAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEI--LPATRGMNGDSSENQALGP 371
KA P P E + ++ + SEEE L T G QA
Sbjct: 668 KAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG--------QAKSV 718
Query: 372 QPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIP 431
KA G L + A L + + + + DS+S E+ ++ A P
Sbjct: 719 GKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778
Query: 432 TTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPC 491
V T A P + S S+PG ++ +A A P V+ P+ + P
Sbjct: 779 AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK--VKPPVRN-PQ 835
Query: 492 TDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRS 551
++ P S + K +T P + S E SE + L QV+
Sbjct: 836 NSTVLARG------PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK- 888
Query: 552 FVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTA 611
P T + + + P R+ PT S A + +E S
Sbjct: 889 ---PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP--SAAQAGKQDDSGSSSEESDSDG 943
Query: 612 EL-AAKSGPQVI-----------PPASEKTLPIQAQSQGSRTPLMAESSPTNSPSS---- 655
E AA + QVI PA P QAQ+ + A S S SS
Sbjct: 944 EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESED 1003
Query: 656 -----GNHLATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSS--SDMEKFTEIIKQMD 708
TP VT P S S +SS SD +K Q+D
Sbjct: 1004 EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVD 1063
Query: 709 SAV 711
SAV
Sbjct: 1064 SAV 1066
Score = 38.5 bits (88), Expect = 0.057
Identities = 144/743 (19%), Positives = 236/743 (31%), Gaps = 112/743 (15%)
Query: 16 SQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVASAAS 75
S TD G + P + A AA A KV + GG A
Sbjct: 206 SSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP----APGKVGDVTPQVKGGALPPAK 261
Query: 76 PESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRAPAKESPPK 135
KP ++ G + P S K + + A AP P A +PP
Sbjct: 262 RAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPG 321
Query: 136 RVPDPSPVTKGTAAESGEEA--------------------ARAIPRELPVKSSSLLPEIK 175
+ + TK E E+ A+A + V ++S +
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKES 381
Query: 176 PEHKRGPLPNHFNG----RAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKV 231
P P P G +A+ G+ E +++ SD++ P G++
Sbjct: 382 PRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE--ESDSEEEAPAQAKPSGKAPQVRAA 439
Query: 232 TLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIR 291
+ PAK + P + P + V G E+ R++S +D
Sbjct: 440 SAPAKESPRKGAAPAPP------RKTGPAAAQVQVGKQE------EDSRSSSEESDSDRE 487
Query: 292 GQRNTPASSKTFVGRAKLNLAKKAKEMEQ----------PEKKVMPNSPQNGVLVKETAI 341
A+ +G++ K A M P KV P +P V E
Sbjct: 488 ALAAMNAAQVKPLGKSP--QVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 545
Query: 342 ETKVTVSEEEI---LPATRGMNGDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIP 398
E+ S + +P + S L +P AG PVA +
Sbjct: 546 ESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG----PVAVQVKA 601
Query: 399 VK--DHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLP----PTAMPKPQHTFS 452
K D+ +E S++ADS+ A+ TK P TA K
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 453 DSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNN 512
+Q+P ++ S + S+PA + P D SE S
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGG----------TQRPAEDSSSSEE--------SDSEE 703
Query: 513 EKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVI----- 567
EK L G+ ++VG +QV++ +PV+ + + +
Sbjct: 704 EKTGLAVTVGQA----------KSVGKG------LQVKAASVPVKGSLGQGTAPVLPGKT 747
Query: 568 -PESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPAS 626
P ++V+ + S+E E S + A P + + + A AA P S
Sbjct: 748 GPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTIS 807
Query: 627 EKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAG- 685
+ A +Q + P +P + LA R +V + + A+ G
Sbjct: 808 APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLA---RGPASVPSVGKAVATAAQAQTGP 864
Query: 686 -SDDSVFDSSSDMEKFTEIIKQM 707
D + SD E+ E + Q+
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQV 887
>gi|21389517 gammaN-crystallin [Homo sapiens]
Length = 182
Score = 66.6 bits (161), Expect = 2e-10
Identities = 36/114 (31%), Positives = 56/114 (49%), Gaps = 6/114 (5%)
Query: 1121 RVSHIDLFTEPEGLGILSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFI 1180
R I L+ G F D + Q G M + S+ V G W+ + P F+G FI
Sbjct: 4 RSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFI 63
Query: 1181 LEPGEYPDLSFWDTEAAYIGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVE 1234
LE G+YPD W++ + ++GS RP+ M G ++ ++E F G+C+E
Sbjct: 64 LEHGDYPDFFRWNSHSDHMGSCRPVGMHGEHF------RLEIFEGCNFTGQCLE 111
Score = 63.5 bits (153), Expect = 2e-09
Identities = 35/126 (27%), Positives = 60/126 (47%), Gaps = 7/126 (5%)
Query: 1323 MYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKG 1382
+Y K+F G ++V G N ++ G+ + SI+V SG WV + +PDF G+Q+IL+ G
Sbjct: 10 LYEGKHF--TGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHG 67
Query: 1383 FYTSFEDWGGKNCKISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHSQSFEETTSQIDDS 1442
Y F W + + S +P+ + ++ +F F G F E + +
Sbjct: 68 DYPDFFRWNSHSDHMGSCRPVGMHG-----EHFRLEIFEGCNFTGQCLEFLEDSPFLQSR 122
Query: 1443 FSTKSC 1448
K+C
Sbjct: 123 GWVKNC 128
Score = 59.3 bits (142), Expect = 3e-08
Identities = 29/90 (32%), Positives = 51/90 (56%), Gaps = 1/90 (1%)
Query: 1504 IILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPA 1563
I L+E + F G+K+E+ + N + GF ++ S+ V G WV + + +RG+QF+L
Sbjct: 8 ITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHG 67
Query: 1564 EVPNWYEF-SGCRQIGSLRPFVQKRIYFRL 1592
+ P+++ + S +GS RP +FRL
Sbjct: 68 DYPDFFRWNSHSDHMGSCRPVGMHGEHFRL 97
Score = 50.8 bits (120), Expect = 1e-05
Identities = 28/94 (29%), Positives = 44/94 (46%), Gaps = 12/94 (12%)
Query: 1219 KVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEK 1278
K+ +YE F G+ +E+ G C + G V S+ V G WV +
Sbjct: 7 KITLYEGKHFTGQKLEV-FGDCDNFQDRGFMNR-----------VNSIHVESGAWVCFNH 54
Query: 1279 PGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPI 1312
P F G Q++LE G+Y D+ W ++ + S RP+
Sbjct: 55 PDFRGQQFILEHGDYPDFFRWNSHSDHMGSCRPV 88
Score = 40.8 bits (94), Expect = 0.011
Identities = 35/147 (23%), Positives = 65/147 (44%), Gaps = 7/147 (4%)
Query: 1412 RRRNQIHLFSEPQFQGHS-QSFEETTSQIDDSFSTK--SCRVSGGSWVVYDGENFTGNQY 1468
+R +I L+ F G + F + + D F + S V G+WV ++ +F G Q+
Sbjct: 3 QRSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQF 62
Query: 1469 VLEEGHYPCLSAMGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNLRS 1528
+LE G YP S R + + + +FE +F G+ +E ++ L+S
Sbjct: 63 ILEHGDYPDFFRWN-SHSDHMGSCRPVGMHGEHFRLEIFEGCNFTGQCLEFLEDSPFLQS 121
Query: 1529 LGF-NTQIRSVQVI--GGIWVTYEYGS 1552
G+ + +++V G W +G+
Sbjct: 122 RGWVKNCVNTIKVYGDGAAWSPRSFGA 148
Score = 37.4 bits (85), Expect = 0.13
Identities = 19/65 (29%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
Query: 1020 RPGKVVIYSEPDVSEKCIEVFSDIQDCSSWS-LSPVILIKVVRGCWILYEQPNFEGHSIP 1078
R GK+ +Y + + +EVF D + ++ V I V G W+ + P+F G
Sbjct: 4 RSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFI 63
Query: 1079 LEEGE 1083
LE G+
Sbjct: 64 LEHGD 68
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 64.3 bits (155), Expect = 1e-09
Identities = 134/630 (21%), Positives = 226/630 (35%), Gaps = 120/630 (19%)
Query: 2 EKRSSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKS 61
E++ + G+ + ++ G + E +S ++A ++ A + + A + + KS
Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEET-KSPPAEEAASPEKEAKSPVKEEAKSPAEAKS 532
Query: 62 PRAALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRS----RALEAV 117
P A SPE SP + +K PP A SP K + +S ++ E
Sbjct: 533 PEKEEAKSPAEVKSPEKAKSPA--------KEEAKSPPEAKSPEKEEAKSPAEVKSPEKA 584
Query: 118 PAPPASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLP-EIK- 175
+P ++PA+ P++ P EEA + PVK + P E+K
Sbjct: 585 KSPAKEEAKSPAEAKSPEKAKSPVK----------EEAKSPAEAKSPVKEEAKSPAEVKS 634
Query: 176 PEHKRGPLPNHFNGRAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPA 235
PE + P E +S E ++ A + K S V + P
Sbjct: 635 PEKAKSP-------TKEEAKSPEKAKSPEKEEAKSPEKAK---------SPVKAEAKSPE 678
Query: 236 KPKH-VELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPR--HTDIRG 292
K K V+ K+P+ S PV + + + + K SP + ++
Sbjct: 679 KAKSPVKAEAKSPEKAKS----------PVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728
Query: 293 QRNTPASSKTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEI 352
+ TP +K+ V +E + PEK SP+ + + E K EE
Sbjct: 729 EAKTPEKAKSPV----------KEEAKSPEK---AKSPEKAKTLDVKSPEAKTPAKEEAR 775
Query: 353 LPATRGMNGDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIPVK-DHKLLEKEDSE 411
PA D +A P K +V++ A P+K D K EKE +
Sbjct: 776 SPA------DKFPEKAKSPV-----KEEVKSP--------EKAKSPLKEDAKAPEKEIPK 816
Query: 412 AADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAP 471
+ KS V E ++ P V K+ P A + ++ +S + AP
Sbjct: 817 KEEVKSPVKE------EEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAP 870
Query: 472 APG-DVPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLST 530
P + K+ V+ P S + +E+ K P E +E+ + P T
Sbjct: 871 KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTP----EKEAPAKVEVKEDAKPKEKT 926
Query: 531 E---RSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPE 587
E + P+ ++ PS+ P E + PE + +E + E
Sbjct: 927 EVAKKEPDDAKAKEPSK----------PAE-----KKEAAPEKKDTKEEKA----KKPEE 967
Query: 588 VVSVASCAPPQEEVLGNEHSHCTAELAAKS 617
+ A ++ L E S AE A KS
Sbjct: 968 KPKTEAKAKEDDKTLSKEPSKPKAEKAEKS 997
Score = 35.0 bits (79), Expect = 0.63
Identities = 79/420 (18%), Positives = 148/420 (35%), Gaps = 61/420 (14%)
Query: 267 GNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLAKKAKEMEQPEKKVM 326
G TK E + + ++ + +PA +K+ + AK E++ PEK
Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS----PEKEEAKSPAEVKSPEKAKS 552
Query: 327 PNSPQNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQALGPQPNQDDKADVQTDAG 386
P + ++ E K EE PA S +A P +
Sbjct: 553 PAKEE-----AKSPPEAKSPEKEEAKSPAEV-----KSPEKAKSPAKEE----------- 591
Query: 387 CLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQ-------DIPTTVDTKDL 439
++ A A P K +++E A++KS V E A+ PT + K
Sbjct: 592 --AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP 649
Query: 440 PPTAMPKPQHTFSD--SQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVS 497
P+ + S ++SP ++ +P + +SP+ + K
Sbjct: 650 EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE----EAKSP 705
Query: 498 ENHKGCVLPVSRQNNE-KMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRSFVLPV 556
E K V ++ + K P+ E E P +SP ++ P + ++ L V
Sbjct: 706 EKAKSPVKEEAKSPEKAKSPVKE---EAKTP-EKAKSPVKEEAKSPEKAKSPEKAKTLDV 761
Query: 557 ESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAK 616
+S PE+ + + + PE +P +EEV E + + AK
Sbjct: 762 KS---------PEAKTPAKEEARSPADKFPEKAK----SPVKEEVKSPEKAKSPLKEDAK 808
Query: 617 SGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSP 676
+ + IP E P++ + + + P ATP+ ++ + +++P
Sbjct: 809 APEKEIPKKEEVKSPVKEEEKPQEVKV---KEPPKKAEEEKAPATPKTEEKKDSKKEEAP 865
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 63.2 bits (152), Expect = 2e-09
Identities = 135/629 (21%), Positives = 219/629 (34%), Gaps = 94/629 (14%)
Query: 5 SSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRA 64
+S ++G+ +S+ +D+E AA+ A+ + + + A++ +SPR
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAK--ALLQAKASGKTSQVGAASAPAKESPRK 384
Query: 65 ALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASG 124
+A +P K P G+ + Q S ++ + ++A + AP
Sbjct: 385 G------AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 125 PRAPAKESPPKRVPDPSPVTKGTAA-------------ESGEEA-----ARAIPRELPVK 166
APAKESP K P G AA S EE+ A A VK
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
Query: 167 SSSLLPEIKPEHK---------RGPLPNHFNG----RAEGGRSRELGRAAGAPGASDADG 213
P++KP GP+P G A+ G+ E ++ + +DG
Sbjct: 499 PLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 214 -----LKPRNHFGVGRSTVTTKVTLPAK-------PKHVELNLKTP--------KNLDSL 253
+ P +G + PAK P V++ + P ++ DS
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 618
Query: 254 GNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLAK 313
+E P + + A KI +T + P+ T NT AS+K R +
Sbjct: 619 DSEEAPAAMTAAQAKPALKI-----PQTKACPKKT------NTTASAKVAPVRVGTQAPR 667
Query: 314 KAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEI--LPATRGMNGDSSENQALGP 371
KA P P E + ++ + SEEE L T G QA
Sbjct: 668 KAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG--------QAKSV 718
Query: 372 QPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIP 431
KA G L + A L + + + + DS+S E+ ++ A P
Sbjct: 719 GKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 778
Query: 432 TTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPC 491
V T A P + S S+PG ++ +A A P V+ P+ + P
Sbjct: 779 AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK--VKPPVRN-PQ 835
Query: 492 TDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRS 551
++ P S + K +T P + S E SE + L QV+
Sbjct: 836 NSTVLARG------PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK- 888
Query: 552 FVLPVESTQDVSSQVIPESSEVREVQLPT 580
P T + + + P R+ PT
Sbjct: 889 ---PSGKTHQIRAALAPAKESPRKGAAPT 914
Score = 38.5 bits (88), Expect = 0.057
Identities = 144/743 (19%), Positives = 236/743 (31%), Gaps = 112/743 (15%)
Query: 16 SQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVASAAS 75
S TD G + P + A AA A KV + GG A
Sbjct: 206 SSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP----APGKVGDVTPQVKGGALPPAK 261
Query: 76 PESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRAPAKESPPK 135
KP ++ G + P S K + + A AP P A +PP
Sbjct: 262 RAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPG 321
Query: 136 RVPDPSPVTKGTAAESGEEA--------------------ARAIPRELPVKSSSLLPEIK 175
+ + TK E E+ A+A + V ++S +
Sbjct: 322 KAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKES 381
Query: 176 PEHKRGPLPNHFNG----RAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKV 231
P P P G +A+ G+ E +++ SD++ P G++
Sbjct: 382 PRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE--ESDSEEEAPAQAKPSGKAPQVRAA 439
Query: 232 TLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIR 291
+ PAK + P + P + V G E+ R++S +D
Sbjct: 440 SAPAKESPRKGAAPAPP------RKTGPAAAQVQVGKQE------EDSRSSSEESDSDRE 487
Query: 292 GQRNTPASSKTFVGRAKLNLAKKAKEMEQ----------PEKKVMPNSPQNGVLVKETAI 341
A+ +G++ K A M P KV P +P V E
Sbjct: 488 ALAAMNAAQVKPLGKSP--QVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 545
Query: 342 ETKVTVSEEEI---LPATRGMNGDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIP 398
E+ S + +P + S L +P AG PVA +
Sbjct: 546 ESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG----PVAVQVKA 601
Query: 399 VK--DHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLP----PTAMPKPQHTFS 452
K D+ +E S++ADS+ A+ TK P TA K
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 453 DSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNN 512
+Q+P ++ S + S+PA + P D SE S
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGG----------TQRPAEDSSSSEE--------SDSEE 703
Query: 513 EKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVI----- 567
EK L G+ ++VG +QV++ +PV+ + + +
Sbjct: 704 EKTGLAVTVGQA----------KSVGKG------LQVKAASVPVKGSLGQGTAPVLPGKT 747
Query: 568 -PESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPAS 626
P ++V+ + S+E E S + A P + + + A AA P S
Sbjct: 748 GPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTIS 807
Query: 627 EKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAG- 685
+ A +Q + P +P + LA R +V + + A+ G
Sbjct: 808 APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLA---RGPASVPSVGKAVATAAQAQTGP 864
Query: 686 -SDDSVFDSSSDMEKFTEIIKQM 707
D + SD E+ E + Q+
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQV 887
Score = 37.4 bits (85), Expect = 0.13
Identities = 38/155 (24%), Positives = 53/155 (34%), Gaps = 17/155 (10%)
Query: 16 SQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVASAAS 75
S K T + A +A+ +V AA + KVK P A
Sbjct: 784 SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARG 843
Query: 76 PESKPSPGT---------------KGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAP 120
P S PS G G ESD S++ + K G++ + A AP
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESD-SEEEAETLAQVKPSGKTHQIRAALAP 902
Query: 121 PASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEA 155
PR A +PP + PS G +SG +
Sbjct: 903 AKESPRKGAAPTPPGKT-GPSAAQAGKQDDSGSSS 936
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 59.7 bits (143), Expect = 2e-08
Identities = 175/788 (22%), Positives = 258/788 (32%), Gaps = 163/788 (20%)
Query: 48 AASDNASAEKKVKSPRAALDGGVASAASPESKPSP------GTKGQLRGESDRSKQPPPA 101
A S +S+ KK ++ A G+ ++ SP+ P+P KG S + PPA
Sbjct: 910 ALSMTSSSPKKARATPAPK--GIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPA 967
Query: 102 SSPTKRKG--RSRALEAVPAPPASGPRAP----AKESP-------------PKRVPDPSP 142
++P KG + + + P PPA+ P +P A SP PK P +P
Sbjct: 968 ATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATP 1027
Query: 143 VTKGTA--------AESGEEAARAIPRELPVKSSSLLPEIK-----PEHKRGPLPNHFNG 189
KG + + G AA +P+ P ++ LP K P K P P
Sbjct: 1028 FPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATP 1087
Query: 190 RA-EGGRSRELGRAAGAPGA----SDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNL 244
+ +GG + + A P A S GL H G TT P PK L
Sbjct: 1088 PSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAP----TTPAATPPSPKG---GL 1140
Query: 245 KTPKNLDSLGNEHNPFSQPVH-KGNTAT---KISLFENKRTNSSPRH----TDIRGQRNT 296
TP G P + P KG AT K + T SP+ +G T
Sbjct: 1141 ATPP---PKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1197
Query: 297 PASSKTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLV---KETAIETKVTVSEEEIL 353
PA++ K LA + + P SP+ G+ K T +
Sbjct: 1198 PAATPP---SPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG 1254
Query: 354 PATRGMNGDSSENQALGPQ-------------PNQDDKADVQTDAGCLSEPVASALIPVK 400
PAT G + A P PN G + P A P
Sbjct: 1255 PATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPA 1314
Query: 401 DHKLLEKEDSEAADSKSL---------------VLENVTDTAQDIPTTVDTKDLPPTAMP 445
K K L T +++ PTT +K+ P
Sbjct: 1315 ATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAA 1374
Query: 446 KPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPIS-----SFPCTDLKVSENH 500
P H + +P GP++ P+P P V P+S + P T +
Sbjct: 1375 TPSHKGGPAMTPPSPKRGPAI----PSPKGDPTSPAV-IPLSPKKAPATPVTREGAATPS 1429
Query: 501 KGCVLP--VSRQNNEKMPLLEL--GGETTP--------PLSTERSPE------------- 535
KG + P V+ + +K P GG TP P T SP+
Sbjct: 1430 KGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSS 1489
Query: 536 -----------------AVGSECPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQL 578
AV P V S P+ T + S+ P + +E +
Sbjct: 1490 PKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALI 1549
Query: 579 PTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAA-----KSGPQ----VIPPASEKT 629
P + P + P+E ++ A K P +IPPA
Sbjct: 1550 PPAMT-VPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSP 1608
Query: 630 LPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAGSDDS 689
P +A + + TP E P G TP P T ++ +DSP S +++ +
Sbjct: 1609 SPKEAPTPPAVTPPSPEKGPATPAPKG----TPTSPPVTPSSLKDSPTSPASVTCKMGAT 1664
Query: 690 VFDSSSDM 697
V +S +
Sbjct: 1665 VPQASKGL 1672
Score = 50.8 bits (120), Expect = 1e-05
Identities = 80/343 (23%), Positives = 119/343 (34%), Gaps = 55/343 (16%)
Query: 42 DEVAPNAASDNASAEKKVKSPRAALDGGVASAASPESKPS-PGTKGQLRGESDRSKQPPP 100
D +AP A + + +P+ AL + SP+ P+ P K S + PP
Sbjct: 1525 DPIAPTATLLSKKTPATL-APKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPP 1583
Query: 101 ASSPTKRKG-------------RSRALEAVPAPPASGPRAPAK---ESPPKRVPDPSPVT 144
A +P+ KG S + + P PPA P +P K PK P PVT
Sbjct: 1584 AVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVT 1643
Query: 145 KGTAAESGEEAA-------RAIP---RELPVKSSSLLPEIKPEHKRGPLPNH---FNGRA 191
+ +S A +P + LP K P E P P
Sbjct: 1644 PSSLKDSPTSPASVTCKMGATVPQASKGLPAKKG---PTALKEVLVAPAPESTPIITAPT 1700
Query: 192 EGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNLKTPKNLD 251
G + A P D +N STV LP + + KT K D
Sbjct: 1701 RKGPQTKKSSATSPPICPDPSA---KNGSKGPLSTVAPAPLLPVQKD----SSKTAKGKD 1753
Query: 252 SLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNL 311
+ + P + P K +T + FE + P + + P S L L
Sbjct: 1754 ASHSPKGPLAPPESKASTPLTAAAFE--KVLPKPESASVSAAPSPPVS---------LPL 1802
Query: 312 AKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILP 354
A P+++ +P+SP LV E+ + E+E+LP
Sbjct: 1803 APSPVPTLPPKQQFLPSSPG---LVLESPSKPLAPADEDELLP 1842
Score = 50.4 bits (119), Expect = 1e-05
Identities = 169/821 (20%), Positives = 277/821 (33%), Gaps = 162/821 (19%)
Query: 68 GGVASAASPESKPS------PGTKGQLRGESDRSKQPPPASSPTKRKG---------RSR 112
GG+A+ SP+ P+ P KG L S + PA++P KG
Sbjct: 1184 GGLATP-SPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPT 1242
Query: 113 ALEAVPAPPASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLP 172
A P P GP P PPK P P T P L
Sbjct: 1243 TPAATPPSPKGGPATP----PPKGAPTPPAATP------------------PSLKGGL-- 1278
Query: 173 EIKPEHKRGPLPNHFNGRA-EGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKV 231
P HK P P + +GG + + A P A+ K + T
Sbjct: 1279 -ATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPA 1337
Query: 232 TLPAKPKHVELNLKT-------PKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSS 284
P PK T P S P + P HKG A T S
Sbjct: 1338 VTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPA---------MTPPS 1388
Query: 285 P-RHTDIRGQRNTPASSKTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVL----VKET 339
P R I + P S A + L+ K K P + +P G L V
Sbjct: 1389 PKRGPAIPSPKGDPTSP------AVIPLSPK-KAPATPVTREGAATPSKGDLTPPAVTPV 1441
Query: 340 AIETKVTVSEEEILPATRGMNGD------SSENQALGPQPNQDDKADVQTDAGCLSEPVA 393
+++ S + PAT GD + + P P Q + A P+
Sbjct: 1442 SLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMG 1501
Query: 394 SALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKD--LPPT--------- 442
+ +P ++ + + + + T ++ P T+ K+ +PP
Sbjct: 1502 APTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKT 1561
Query: 443 -AMPKPQHTFSDSQSPAESSP---GPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSE 498
A+P P+ + S SSP PS AP+P ++ V SP T
Sbjct: 1562 PAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPT------ 1615
Query: 499 NHKGCVLPVSRQNNEKMPLLELGGETTPPL---STERSPEAVGS-ECPSRVLVQVRSFVL 554
V P S + P + G T+PP+ S + SP + S C V S L
Sbjct: 1616 --PPAVTPPSPEKGPATPAPK-GTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGL 1672
Query: 555 PVESTQDVSSQVI----PESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCT 610
P + +V+ PES+ + + PT P+ ++ +PP
Sbjct: 1673 PAKKGPTALKEVLVAPAPESTPI--ITAPT--RKGPQTKKSSATSPP-----------IC 1717
Query: 611 AELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVT 670
+ +AK+G + P+ + P+ +SS T +H +P+ P
Sbjct: 1718 PDPSAKNGSKG---------PLSTVAPAPLLPVQKDSSKTAKGKDASH--SPKGPLAPPE 1766
Query: 671 NGQDSPASLLNISAGSDDSVF----DSSSDMEKFTEIIKQMDSAVCMPMKRKKARMPNSP 726
+ +P ++A + + V +S + + + + K+ +P+SP
Sbjct: 1767 SKASTP-----LTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSP 1821
Query: 727 -----APHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNLDT--KSKL 779
+P + P ED L + P+ + G+ P ++ N+ T + +
Sbjct: 1822 GLVLESPSKPLAPADEDELLPLIPPEPISGGV-----------PFQSVLVNMPTPKSAGI 1870
Query: 780 RPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVT 820
SA+Q V + + T +S+ V PE+ ++++ T
Sbjct: 1871 PVPTPSAKQPVTKNNKGSGTESDSDESV-PELEEQDSTQAT 1910
Score = 44.7 bits (104), Expect = 8e-04
Identities = 147/726 (20%), Positives = 233/726 (32%), Gaps = 74/726 (10%)
Query: 22 SPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVASAASPES-KP 80
+P A P S A + APN A + K + AA+P S K
Sbjct: 1263 APTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKG 1322
Query: 81 SPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRAPAKESPPKRVPDP 140
SPGT PPP +PT + + P PA+ P + + P P
Sbjct: 1323 SPGT-------------PPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGP 1369
Query: 141 SPVTKGTAAESGEEAARAIPRELPV----KSSSLLPEIKP-EHKRGPLPNHFNGRAEGGR 195
+P + + G P+ P K P + P K+ P A
Sbjct: 1370 TPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPS 1429
Query: 196 SRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNLKTPKNLDSLGN 255
+L A P + G + TLPA PK + + +
Sbjct: 1430 KGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSS 1489
Query: 256 EHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLAKKA 315
+ P G + SSP+ TP+S + + L+KK
Sbjct: 1490 PKKAPATPAPMGAPTLPAVI------PSSPKEVPA-----TPSSRRDPIAPTATLLSKKT 1538
Query: 316 KEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQAL---GPQ 372
P++ ++P + K AI T E P+++ + + + P
Sbjct: 1539 PATLAPKEALIPPAMTVPSPKKTPAIPTP---KEAPATPSSKEASSPPAVTPSTYKGAPS 1595
Query: 373 PNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTA-QDIP 431
P + T P A+ P EK + A + VT ++ +D P
Sbjct: 1596 PKELLIPPAVTSPSPKEAPTPPAVTPPSP----EKGPATPAPKGTPTSPPVTPSSLKDSP 1651
Query: 432 TTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSL---SLSAPAPGDVPKDTCVQSPISS 488
T+ P + K T + + GP+ L APAP P + +P
Sbjct: 1652 TS------PASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTP---IITAPTRK 1702
Query: 489 FPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVG---SECPSRV 545
P T + + C P S +N K PL + P+ + S A G S P
Sbjct: 1703 GPQTKKSSATSPPICPDP-SAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGP 1761
Query: 546 LVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNE 605
L S T +V+P+ P+ + P S PP+++ L +
Sbjct: 1762 LAPPES-KASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPS- 1819
Query: 606 HSHCTAELAAKSGPQVIPPASEKTL----PIQAQSQGSRTPLMAESSPTNSPSSGNHLAT 661
+ L +S + + PA E L P + S G + + PT S+G + T
Sbjct: 1820 ----SPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPT-PKSAGIPVPT 1874
Query: 662 PQRPDQTVTNGQ------DSPASLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPM 715
P N + DS S+ + + + EI ++ S
Sbjct: 1875 PSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSR 1934
Query: 716 KRKKAR 721
KKAR
Sbjct: 1935 SEKKAR 1940
Score = 40.4 bits (93), Expect = 0.015
Identities = 76/335 (22%), Positives = 106/335 (31%), Gaps = 38/335 (11%)
Query: 373 PNQDDKADVQTDAGCLSEPVA---SALIPVKDHKLLEKEDSEA------------ADSKS 417
P + A T G LS PV+ ++ +P +DS A A + S
Sbjct: 809 PTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPS 868
Query: 418 LVL----ENVTDTAQDIPTTVDT-----KDLPPTAMPKPQHTFS-DSQSP--AESSPGPS 465
V + VT ++ PT K+ P T PK S S SP A ++P P
Sbjct: 869 AVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPK 928
Query: 466 LSLSAPAPGDVPKDTCVQSPI-SSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGET 524
++P+P P P P T P S + P + G
Sbjct: 929 GIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPK--GAP 986
Query: 525 TPPLSTERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSN 584
TPP +T SP+ G PS V P ++ P+ + P
Sbjct: 987 TPPAATPPSPKG-GPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKG 1045
Query: 585 EPEVVSVASCAP--PQEEVLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTP 642
P + AP P + + T L P P S K P +G+ P
Sbjct: 1046 SPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMP 1105
Query: 643 LMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPA 677
A PS LATP T P+
Sbjct: 1106 PAA-----TPPSPKGGLATPPHKGAPTTPAATPPS 1135
Score = 37.7 bits (86), Expect = 0.097
Identities = 74/317 (23%), Positives = 105/317 (33%), Gaps = 62/317 (19%)
Query: 393 ASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFS 452
A+ +P + +L + + A S L Q PT LPP P PQ
Sbjct: 5 ATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPT------LPPPCSPAPQQ--C 56
Query: 453 DSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNN 512
+ ++SP PS S A P +VP FP ++ G LP+
Sbjct: 57 PLSAANQASPFPSPSTIASTPLEVP-----------FP-------QSSSGTALPLGTAPE 98
Query: 513 EKMPLLELGGETTPP-----LSTERSPEAVGSECPSRVLVQV--------RSFVLPVEST 559
L L G P S +P G+ S L V +S P
Sbjct: 99 APTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLL 158
Query: 560 QDVSSQVIPESSEVREVQLPTCHSNEP---------EVVSVASCAPPQEEVLGNEHSHCT 610
S + ES V + P S EP EVV P ++ HC
Sbjct: 159 TSPPSVAVAESGSVITLSAPIAPS-EPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCV 217
Query: 611 AELAA-KSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTV 669
+A+ +SG +P +T P T L S + + L +PQ P
Sbjct: 218 TPMASIQSGVASLP----QTTP--------TTTLAIASPQVKDTTISSVLISPQNPGSLS 265
Query: 670 TNGQDSPASLLNISAGS 686
G SP + L++S S
Sbjct: 266 LKGPVSPPAALSLSTQS 282
Score = 37.4 bits (85), Expect = 0.13
Identities = 141/672 (20%), Positives = 208/672 (30%), Gaps = 110/672 (16%)
Query: 61 SPRAALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAP 120
+P+ A + S++ +++ +P KG S + PPA++P KG
Sbjct: 904 APKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKG----------- 952
Query: 121 PASGPRAPAKE---SPPKRVPDPSPVTKGTAAESGEEAARAIPRELP-----------VK 166
GP P+ + +PP P PSP KG A + A P P K
Sbjct: 953 ---GPATPSPKWAPTPPAATP-PSP--KGGPATPSPKGAPTPPAATPPSPKGGPATPSPK 1006
Query: 167 SSSLLPEIKPEHKRG-----PLPNHFNGRAEGGRSRELGRAA------GAPGASDADGLK 215
+ P + P +G P P + G A GAP A
Sbjct: 1007 GAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPS 1066
Query: 216 PRNHFGVG--RSTVTTKVTLPAKPKHVELNLKTPKN--LDSLGNEHNP---FSQPVHKGN 268
P+ + T P PK +PK + +P + P HKG
Sbjct: 1067 PKGGPATPSLKGAPTPPAATPPSPKGGPAT-PSPKGAPMPPAATPPSPKGGLATPPHKGA 1125
Query: 269 TATKISLFENKRTNSSPR----HTDIRGQRNTPASSKTFVGRAKLNLAKKAKEMEQPEKK 324
T + T SP+ +G TPA++ K LA +
Sbjct: 1126 PTTPAA------TPPSPKGGLATPPPKGAPTTPAATPP---SPKGGLATPPPKGAPTTPA 1176
Query: 325 VMPNSPQNGVLV---KETAIETKVTVSEEEILPATRGMNGDSSENQALGPQPNQDDKADV 381
P SP+ G+ K T + AT G + A P P K +
Sbjct: 1177 ATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSP----KGGL 1232
Query: 382 QTDA--GCLSEPVASALIPVKDHKLLEKEDS---EAADSKSLVLENVTDTAQDIP----- 431
T + G + P A+ P + + AA SL T + P
Sbjct: 1233 ATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVV 1292
Query: 432 TTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPI-SSFP 490
T K P T+ PK T PA + P P S P P P V P P
Sbjct: 1293 TPPSPKGGPATSPPKGAPT-----PPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTP 1347
Query: 491 CTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVR 550
+ G P S++ TPP +T PS R
Sbjct: 1348 TLPATTPSSKGGPTTPSSKEG------------PTPPAATPSHKGGPAMTPPS----PKR 1391
Query: 551 SFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCT 610
+P S VIP S ++ S PP + + + T
Sbjct: 1392 GPAIPSPKGDPTSPAVIPLSP--KKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPAT 1449
Query: 611 AELAAKSGPQVIPPASEKTLPIQAQSQGSRTP----LMAESSPTNSPSSGNHLATPQRPD 666
+ A K GP + TLP P + SSP +P++ + P P
Sbjct: 1450 S--APKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPA 1507
Query: 667 QTVTNGQDSPAS 678
++ ++ PA+
Sbjct: 1508 VIPSSPKEVPAT 1519
Score = 33.9 bits (76), Expect = 1.4
Identities = 51/207 (24%), Positives = 76/207 (36%), Gaps = 31/207 (14%)
Query: 480 TCVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGS 539
TCV P+SS P ++++ + + PV+ + L +PPL PE +
Sbjct: 461 TCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLP---DPEDL-K 516
Query: 540 ECPSRVLVQVRSFVLPVESTQDVSSQVIPESSE---VREVQLPTCHSNEPEVVSVASCAP 596
PS VLV+ P + Q +P S E Q +P V+ + AP
Sbjct: 517 NLPSSVLVK-----FPTQK----DLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAP 567
Query: 597 PQEEVLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSG 656
+ + S IP + E TL +S G P+ +S SP
Sbjct: 568 KN-----------SPSFQSTSSSPEIPLSPEATL--AKKSLGEPLPIGKPASSMTSPLGV 614
Query: 657 NHLATPQRPDQTVTNGQDSPASLLNIS 683
N A+ + D G DS LL S
Sbjct: 615 NSSASVIKTDSYA--GPDSAGPLLKSS 639
Score = 31.6 bits (70), Expect = 7.0
Identities = 60/276 (21%), Positives = 94/276 (34%), Gaps = 47/276 (17%)
Query: 427 AQDIPTTVDTKDLPPTAMPKPQH-----TFSDSQSPAESSP------GPSLSLSAPAPGD 475
A +IP +V + LPP P + + + +P SSP S +A + G
Sbjct: 727 APEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGT 786
Query: 476 VPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLS-----T 530
+ SP+ K KG P + N P+ + P S +
Sbjct: 787 LTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGS 846
Query: 531 ERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVS 590
+ SP S P P S V P S + V LP + P VV+
Sbjct: 847 KDSPATTHSPTP------------PSPKGAPTPSAVTPLSP--KGVTLPPKETPTPSVVN 892
Query: 591 V-------ASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPL 643
+ A+ AP Q L + + S + + K +P +G+ TP
Sbjct: 893 LPFPKEGPATPAPKQAPAL---------SMTSSSPKKARATPAPKGIPASPSPKGAPTPP 943
Query: 644 MA-ESSPTNSPSSGNHLATPQRPDQTVTNGQDSPAS 678
A SP P++ + P P T + + PA+
Sbjct: 944 AATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPAT 979
>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
Length = 5478
Score = 57.8 bits (138), Expect = 9e-08
Identities = 205/1014 (20%), Positives = 327/1014 (32%), Gaps = 101/1014 (9%)
Query: 71 ASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRA--LEAVPAPPASGPRAP 128
AS +P S S T G RGES S+ P ++ T G + L S PR+P
Sbjct: 3838 ASGTTPSSAHST-TSG--RGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSP 3894
Query: 129 AKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRGPLPNH-- 186
P + + T + S + + + L E + P
Sbjct: 3895 TTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETT 3954
Query: 187 -FNGRAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNLK 245
F RE + AS L + G + +T P P + L
Sbjct: 3955 VFPRSTTTSVRREEPTTFHSRPASTHTTLFTEDSTTSGLTEEST--AFPGSPASTQTGLP 4012
Query: 246 TPKNLDSLGNEHNPFSQPVHKGNTATKIS---------LFENKRTNSSPRHTD---IRGQ 293
LG E F P G+T TK+S + E+ + SP T+ + G
Sbjct: 4013 ATLTTADLGEESTTF--PSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGS 4070
Query: 294 RNTPASSK---TFVGR-----AKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKV 345
TP+ S+ TF A L+ A E + P + TA
Sbjct: 4071 PTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGS---THTTAFPDST 4127
Query: 346 TVSEEEILPATRGMNGDSSEN---------QALGPQPNQDDKADVQTDAGCL-SEPVASA 395
T S P T + S+E +LG Q + T+ L + + S
Sbjct: 4128 TTSGLSQEPTTSHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSG 4187
Query: 396 LI----PVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTF 451
L+ P A S S L+ + T Q P++ DT PP+ P
Sbjct: 4188 LVEASTPTHSSTGSLHTTLTPASSTSTGLQEESTTFQSWPSSSDTTPSPPSTTAVPVEVS 4247
Query: 452 SDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQN 511
+ S S+P S S+ G + T V S S G L +R
Sbjct: 4248 TTYHSRPSSTPTTHFSASSTTLGRSEESTTVHS------------SPGATGTALFPTRSA 4295
Query: 512 NEKMPLLELGGETTPPLSTERSPEAV--GSECPSRVLVQVRSFVLPVESTQDVSSQVIPE 569
+ +G TT P+S+ + GS + + + +F S S
Sbjct: 4296 TSVL----VGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTT 4351
Query: 570 SSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPASEKT 629
SS V E + T HS S+ + A P + TA ++ P +++ T
Sbjct: 4352 SSGVSE-ESTTSHSRPG---SMHTTAFPSSTTMPGVSQESTASHSS-------PGSTDTT 4400
Query: 630 LPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAGSDDS 689
L S GS T T SS T PD T +G ++ ++ S GS +
Sbjct: 4401 L-----SPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHT 4455
Query: 690 VFDSSSDMEKFTEIIKQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDPKVF 749
+ +Q +S K P P A +
Sbjct: 4456 TLSPAG------STTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSSTPTT 4509
Query: 750 TFGLGKKKESQPEMSPALHLMQNLDTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMP 809
F + E S +H + T + P R++ V + + ++ G+++ + P
Sbjct: 4510 HFSASSTTLGRSEESTTVH-SSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFP 4568
Query: 810 EINDKENR---DVTNGGIKRSRLEKSALFSSLLSSLPQDKIFSPSVTSVNTMTTAFSTSQ 866
E N R T+ + + +S L P SP T+ + +TS
Sbjct: 4569 ESNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSG 4628
Query: 867 NGSLSQSSVSQPTTEGAPPCGLNKEQSNLLPDNSLKVFNFNSSSTSHSSLKSPSHMEKYP 926
S +S S G S LL +++ + S T ++L +
Sbjct: 4629 RSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMET--TALPGSTTTPGLS 4686
Query: 927 QKEKTKEDLDSRSNLHLPETKFSELS-KLKNDDMEKANHIESVIKSNLPNCANSDTDFMG 985
+K T S + P T FS S L + H V + P+ A S T +
Sbjct: 4687 EKSTTFHSSPSST----PTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLV 4742
Query: 986 LFKSSRYDPSISFSGMSLSDTMTLRG-SVQNKLNPRPGKVVIYSEPDVSEKCIE 1038
++ + S M ++ T G S +++ + I S P + +E
Sbjct: 4743 EESTAYHSSPGSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVE 4796
Score = 51.6 bits (122), Expect = 7e-06
Identities = 151/744 (20%), Positives = 238/744 (31%), Gaps = 101/744 (13%)
Query: 234 PAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKIS---------LFENKRTNSS 284
P P + L LG E F P G+T TK+S + E+ + S
Sbjct: 1361 PGSPASTQTGLPATLTTADLGEESTTF--PSSSGSTGTKLSPARSTTSGLVGESTPSRLS 1418
Query: 285 PRHTD---IRGQRNTPASSK---TFVGR-----AKLNLAKKAKEMEQPEKKVMPNSPQNG 333
P T+ + G TP+ S+ TF A L+ A E + P +
Sbjct: 1419 PSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGS- 1477
Query: 334 VLVKETAIETKVTVSEEEILPATRGMNGDSSEN---------QALGPQPNQDDKADVQTD 384
TA T S+ P T + S+E +LG Q + T+
Sbjct: 1478 --THTTAFPDSTTTSDLSQEPTTSHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTE 1535
Query: 385 AGCL-SEPVASALI----PVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDL 439
L + + S L+ P A S S L+ + T Q P++ DT
Sbjct: 1536 TTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPS 1595
Query: 440 PPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSEN 499
PP P + S S+P S S+ G + T V S S
Sbjct: 1596 PPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHS------------SPG 1643
Query: 500 HKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAV--GSECPSRVLVQVRSFVLPVE 557
G L +R + +G TT P+S+ + GS + + + +F
Sbjct: 1644 ATGTALFPTRSATSVL----VGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPR 1699
Query: 558 STQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKS 617
S S SS V E + T HS S + A P + TA ++
Sbjct: 1700 SPDTTLSPASTTSSGVSE-ESTTSHSRPG---STHTTAFPGSTTMPGVSQESTASHSS-- 1753
Query: 618 GPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPA 677
P +++ TL S GS T T SS T PD T +G +
Sbjct: 1754 -----PGSTDTTL-----SPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEAS 1803
Query: 678 SLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHE 737
+ ++ S GS + + +Q +S K MP P A +
Sbjct: 1804 TPVHSSTGSPHTTLSPAG------STTRQGESTTFQSWPSSKDTMPAPPTTTSAFVELST 1857
Query: 738 DHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLRPKRASAEQSVLFKSLHT 797
F + E S +H + T + P R++ V + +
Sbjct: 1858 TSHGSPSSTPTTHFSASSTTLGRSEESTTVH-SSPVATATTPSPARSTTSGLVEESTAYH 1916
Query: 798 NTNGNSEPLVMPEINDKENRDV---TNGGIKRSRLEKSALFSSLLSSLPQDKIFSPSVTS 854
++ G+++ + PE + R T+ + +S L P SP T+
Sbjct: 1917 SSPGSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSTA 1976
Query: 855 VNTMTTAFSTSQNGSLSQSSVSQPTTEG------------------APPCGLNKEQSNLL 896
+ +TS S +S S G P ++ L
Sbjct: 1977 TTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTAL 2036
Query: 897 PDNSLKVFNFNSSSTSHSSLKSPS 920
P ++ S+T HSS +SP+
Sbjct: 2037 PGSTTTPGLSEKSTTFHSSPRSPA 2060
Score = 47.0 bits (110), Expect = 2e-04
Identities = 173/927 (18%), Positives = 284/927 (30%), Gaps = 141/927 (15%)
Query: 71 ASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRA--LEAVPAPPASGPRAP 128
AS +P S S T G RGES S+ P ++ T G + L S PR+P
Sbjct: 2755 ASGTTPSSAHST-TSG--RGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSP 2811
Query: 129 AKESPPKRVPDPSPVTKGTAAES-------------------GEEAARAIPRELPVKSSS 169
P + + T + S EE+ ++
Sbjct: 2812 TTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETT 2871
Query: 170 LLPEIKPEHKRGPLPNHFNGRAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTT 229
+ P RG P F+ R + + G ++
Sbjct: 2872 VFPRSTTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSGLTEES----------------- 2914
Query: 230 KVTLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKIS---------LFENKR 280
P P + L LG E F P G+T T +S + E+
Sbjct: 2915 -TAFPGSPASTQTGLPATLTTADLGEESTTF--PSSSGSTGTTLSPARSTTSGLVGESTP 2971
Query: 281 TNSSPRHTD---IRGQRNTPASSK---TFVGR-----AKLNLAKKAKEMEQPEKKVMPNS 329
+ SP T+ + G TP+ S+ TF A L+ A E +
Sbjct: 2972 SRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQ 3031
Query: 330 P-------------QNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQALGPQPNQD 376
P +G+ + TA + +E + P + + ++ P
Sbjct: 3032 PGSTHTTAFPDSTTTSGLSQEPTASHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDT 3091
Query: 377 DKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDT 436
+ + D ++ + A P A S S L+ + T Q P++ DT
Sbjct: 3092 ETTLLPDDT--ITSGLVEASTPTHSSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSDT 3149
Query: 437 KDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKV 496
PP P + S S+P S S+ G + T V S
Sbjct: 3150 TPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHS------------ 3197
Query: 497 SENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAV--GSECPSRVLVQVRSFVL 554
S G L +R + +G TT P+S+ + GS + + + +F
Sbjct: 3198 SPGATGTALFPTRSATSVL----VGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYS 3253
Query: 555 PVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELA 614
S S SS V E + T HS S + A P + TA +
Sbjct: 3254 SPRSPDTTLSPASTTSSGVSE-ESTTSHSRPG---STHTTAFPGSTTMPGVSQESTASHS 3309
Query: 615 AKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQD 674
+ P +++ TL S GS T T S T PD T +G
Sbjct: 3310 S-------PGSTDTTL-----SPGSTTASSLGPESTTFHSGPGSTETTLLPDNTTASGLL 3357
Query: 675 SPASLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPMKRKKARMPNSPAPHFAMPP 734
++ ++ S GS + + +Q +S K P P A
Sbjct: 3358 EASTPVHSSTGSPHTTLSPAG------STTRQGESTTFQSWPNSKDTTPAPPTTTSAFVE 3411
Query: 735 IHEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLRPKRASAEQSVLFKS 794
+ F + E S +H + T + P R++ V +
Sbjct: 3412 LSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVH-SSPVATATTPSPARSTTSGLVEEST 3470
Query: 795 LHTNTNGNSEPLVMPEINDKENR---DVTNGGIKRSRLEKSALFSSLLSSLPQDKIFSPS 851
+ ++ G+++ + PE + R T+ + + +S L P SP
Sbjct: 3471 TYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPG 3530
Query: 852 VTSVNTMTTAFSTSQNGSLSQSSVSQPTTEG------------------APPCGLNKEQS 893
T+ + +TS S +S S G P ++
Sbjct: 3531 STATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMET 3590
Query: 894 NLLPDNSLKVFNFNSSSTSHSSLKSPS 920
LP ++ S+T HSS +SP+
Sbjct: 3591 TALPGSTTTPGLSEKSTTFHSSPRSPA 3617
Score = 46.2 bits (108), Expect = 3e-04
Identities = 186/930 (20%), Positives = 281/930 (30%), Gaps = 171/930 (18%)
Query: 71 ASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRA--LEAVPAPPASGPRAP 128
AS +P S S T G RGES S+ P ++ T G + L S PR+P
Sbjct: 2281 ASGTTPSSAHST-TSG--RGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSP 2337
Query: 129 AKESPPKRVPDPSPVTKGTAAES-------------------GEEAARAIPRELPVKSSS 169
P + + T + S EE+ ++
Sbjct: 2338 TTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETT 2397
Query: 170 LLPEIKPEHKRGPLPNHFNGRAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTT 229
+ P RG P F+ R + + G ++
Sbjct: 2398 VFPRTPTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSGLTEES----------------- 2440
Query: 230 KVTLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKIS---------LFENKR 280
P P + L LG E F P G+T T +S + E+
Sbjct: 2441 -TAFPGSPASTQTGLPATLTTADLGEESTTF--PSSSGSTGTTLSPARSTTSGLVGESTP 2497
Query: 281 TNSSPRHTD---IRGQRNTPASSK---TFVGR-----AKLNLAKKAKEMEQPEKKVMPNS 329
+ SP T+ + G TP+ S+ TF A L+ A E +
Sbjct: 2498 SRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQ 2557
Query: 330 PQN-------------GVLVKETAIETKVTVSEEEILPATRGMNGDSSENQALGPQPNQD 376
P + G+ T + ++ +LPA+ +G S E+ P
Sbjct: 2558 PGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGST 2617
Query: 377 DKADVQTDAGCLS---EPVASALIPVKDHKLLEKEDSEA--------------------- 412
D A LS E P H L + + +
Sbjct: 2618 DTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTL 2677
Query: 413 --ADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSA 470
A S S L+ + T Q P + T PP+ P + S+P S+
Sbjct: 2678 SPASSTSPGLQGESTTFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASS 2737
Query: 471 PAPGDVPKDTCVQSPISSFPCTDLKVSENHKG-CVLPVSRQNNEKMPLLELGGETTPPLS 529
G K T S + T G SR + + L G TT P
Sbjct: 2738 TTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGL 2797
Query: 530 TERSPEAVGS-ECPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEV 588
+E S S P+ L S ++S + E S Q + HS
Sbjct: 2798 SEASTTFYSSPRSPTTTL-----------SPASMTSLGVGEESTTSRSQPGSTHS----T 2842
Query: 589 VSVASCAPP---QEEVLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMA 645
VS AS P +E S + E E+ ++ + T L
Sbjct: 2843 VSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRPASTHTTLFT 2902
Query: 646 ESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFT---- 701
E S T S + A P P T T PA+L G + + F SSS T
Sbjct: 2903 EDS-TTSGLTEESTAFPGSPASTQTG---LPATLTTADLGEESTTFPSSSGSTGTTLSPA 2958
Query: 702 -----EIIKQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKK 756
++ + + P + +P SP P + E K TF
Sbjct: 2959 RSTTSGLVGESTPSRLSPSSTETTTLPGSP----TTPSLSE---------KSTTF-YTSP 3004
Query: 757 KESQPEMSPALHLMQNLDTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKEN 816
+ +SPA + +S + + + F T + + EP
Sbjct: 3005 RSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTASHSSQGSTE 3064
Query: 817 RDVTNGGIKRSRL-EKSALFSSL-----LSSLPQDKIFS-------PSVTSV----NTMT 859
++ G S L ++S F S + LP D I S P+ +S T+T
Sbjct: 3065 ATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLT 3124
Query: 860 TAFSTS----QNGSLSQSSVSQPTTEGAPP 885
A STS + + QS S T +PP
Sbjct: 3125 PASSTSAGLQEESTTFQSWPSSSDTTPSPP 3154
Score = 44.3 bits (103), Expect = 0.001
Identities = 162/791 (20%), Positives = 260/791 (32%), Gaps = 91/791 (11%)
Query: 259 PFSQPVHKGNT--------ATKISLFENKRT-NSSPRHTDIRGQRNTPASSKTFVGRAKL 309
P + P+ G+T T L E T SSPR D +PAS+ T G ++
Sbjct: 4303 PTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTT---LSPAST-TSSGVSEE 4358
Query: 310 NLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQAL 369
+ ++ ++ GV + TA + ++ + P S+ +L
Sbjct: 4359 STTSHSRPGSMHTTAFPSSTTMPGVSQESTASHSSPGSTDTTLSPG-------STTASSL 4411
Query: 370 GPQPNQDDKADVQTDAGCLSE-PVASALIPVKD--HKLLEKEDSEAADSKSLVLENVTDT 426
GP+ + T+ L + AS L+ H + + + S + + T
Sbjct: 4412 GPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTT 4471
Query: 427 AQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPI 486
Q P + DT PPT + S S+P S S+ G + T V S
Sbjct: 4472 FQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSP 4531
Query: 487 SSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVL 546
+ T G V + ++ G T + G E
Sbjct: 4532 VATATTPSPARSTTSGLVEESTTYHSSP------GSTQTMHFPESNTTSGRGEE------ 4579
Query: 547 VQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEH 606
S +T +SS S+ V E PT + + P S A+ P
Sbjct: 4580 ----STTSHSSTTHTISSAPSTTSALVEE---PTSYHSSPG--STATTHFPDSSTTSGRS 4630
Query: 607 SHCTAELAAK--SGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQR 664
TA +++ +G V+P S ++ L+ ES T SP S + T
Sbjct: 4631 EESTASHSSQDATGTIVLPARSTTSV------------LLGES--TTSPISSGSMETTAL 4676
Query: 665 PDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPMKRKKARMPN 724
P T T G ++ + S S + S+S T + + +S A P
Sbjct: 4677 PGSTTTPGLSEKSTTFHSSPSSTPTTHFSASS----TTLGRSEESTTVHSSPVATATTP- 4731
Query: 725 SPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLRPKRA 784
SPA + E T PE S A + T
Sbjct: 4732 SPARSTTSGLVEESTAYHSSPGSTQTMHF-------PESSTASGRSEESRTSHSSTTHTI 4784
Query: 785 SAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNGGIKRSRLEKSALFSSLLSSLPQ 844
S+ S + T+ +S P + + E+ T+G + S S+ ++ ++ LP
Sbjct: 4785 SSPPSTTSALVEEPTSYHSSPGSIATTHFPES-STTSGRSEESTASHSSPDTNGITPLPA 4843
Query: 845 DKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTTEGAPPCGLNKEQSNLLPDNSLKVF 904
S + +T F S GS+ + S TT G S+ PD +L
Sbjct: 4844 HFTTSGRIAE----STTFYISP-GSMETTLASTATTPGLSAKSTILYSSSRSPDQTLSPA 4898
Query: 905 NFNSSS-----TSHSSLKSPSHMEKYPQKEKT----KEDLDSRSNLHLPETKFSELSKLK 955
+ SSS TS S +H +P T +E S ET S S
Sbjct: 4899 SMTSSSISGEPTSLYSQAESTHTTAFPASTTTSGLSQESTTFHSKPGSTETTLSPGSITT 4958
Query: 956 NDDMEKANHIESVIKSNLPNCANSDTDFMGLFKSS----RYDPSISFSGMSLSDTMTLRG 1011
+ ++ S S L + + T GL + S S + S S+TM++
Sbjct: 4959 SSFAQEFTTPHSQPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHS 5018
Query: 1012 SVQNKLNPRPG 1022
PG
Sbjct: 5019 QQSTPFPDSPG 5029
Score = 43.9 bits (102), Expect = 0.001
Identities = 211/1089 (19%), Positives = 340/1089 (31%), Gaps = 172/1089 (15%)
Query: 15 GSQKSTDSPG---ADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVA 71
GS +T SPG A + PES + E + AS + +P +
Sbjct: 1755 GSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHS------ 1808
Query: 72 SAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRAPAKE 131
S SP + SP +GES + P + + +PAPP +
Sbjct: 1809 STGSPHTTLSPAGSTTRQGESTTFQSWPSSK------------DTMPAPPTTTSAFVELS 1856
Query: 132 SPPKRVPDPSPVT-------------KGTAAESGEEAARAIPRELPVKSSSLLPEIKPEH 178
+ P +P T + T S A P +S L+ E H
Sbjct: 1857 TTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTAYH 1916
Query: 179 KRG--------PLPNHFNGRAEGGRSRELGRA---AGAPGASDADGLKPRNHFGVGRSTV 227
P + +GR+E R+ + P + A +P ++ ST
Sbjct: 1917 SSPGSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSTA 1976
Query: 228 TTKVTLPAKPK-HVELNLKTPKNLDSLGNEHNPF------------SQPVHKGNTATKIS 274
TT + E + + + D+ G P + P+ G+ T
Sbjct: 1977 TTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTAL 2036
Query: 275 LFENKRTNSSPRHTDIRGQRNTPAS-----SKTFVGRAKLNLAKKAKEMEQPEKKVMPNS 329
S + T +PA+ S T G ++ + ++ ++
Sbjct: 2037 PGSTTTPGLSEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDST 2096
Query: 330 PQNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQALGPQPNQDDKADVQTDAGCLS 389
G+ T + ++ +LPA+ +G S E+ P D A LS
Sbjct: 2097 TTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALS 2156
Query: 390 ---EPVASALIPVKDHKLLEKEDSEA-----------------------ADSKSLVLENV 423
E P H L + + + A S S L+
Sbjct: 2157 FGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGE 2216
Query: 424 TDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQ 483
+ Q P + T PP+ P + S+P S+ G K T
Sbjct: 2217 STAFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFH 2276
Query: 484 SPISSFPCTDLKVSENHKG-CVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGS-EC 541
S + T G SR + + L G TT P +E S S
Sbjct: 2277 SSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRS 2336
Query: 542 PSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPP---Q 598
P+ L S ++S + E S Q + HS VS AS P +
Sbjct: 2337 PTTTL-----------SPASMTSLGVGEESTTSRSQPGSTHS----TVSPASTTTPGLSE 2381
Query: 599 EEVLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNH 658
E S + E E+ ++ + T L E S T S +
Sbjct: 2382 ESTTVYSSSPGSTETTVFPRTPTTSVRGEEPTTFHSRPASTHTTLFTEDS-TTSGLTEES 2440
Query: 659 LATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFT---------EIIKQMDS 709
A P P T T PA+L G + + F SSS T ++ +
Sbjct: 2441 TAFPGSPASTQTG---LPATLTTADLGEESTTFPSSSGSTGTTLSPARSTTSGLVGESTP 2497
Query: 710 AVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHL 769
+ P + +P SP P + E K TF + +SPA
Sbjct: 2498 SRLSPSSTETTTLPGSP----TTPSLSE---------KSTTF-YTSPRSPDATLSPATTT 2543
Query: 770 MQNLDTKSKLRPKRASAEQSVLFK--------SLHTNTN----GNSEPLVMPEINDKENR 817
+ +S + + + F S H+ T+ G+++ ++P
Sbjct: 2544 SSGVSEESSTSHSQPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPA------S 2597
Query: 818 DVTNGGIKRSRLEKSALFS----------SLLSSLPQDKIFSPSVTSVNTMTTAFSTSQN 867
T+G + S S+ S + LS + F S S +T ST+ +
Sbjct: 2598 TTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSS 2657
Query: 868 GSLSQSSVSQPTTEGAPPCGLNKEQSNLLPDNSLKVFNFNSSSTSHSSLKSPSHMEKYPQ 927
G + ++S ++ G+P L+ S+ P + F + S + SP P
Sbjct: 2658 G-IVEASTRVHSSTGSPRTTLS-PASSTSPGLQGESTTFQTHPASTHTTPSPPSTATAPV 2715
Query: 928 KEKTKEDLDSRSNLHLPETKFSELSKLKNDDMEKAN--HIESVIKSNLPNCANSDTDFMG 985
+E T RS P T F S + EK+ H P+ A+S T G
Sbjct: 2716 EESTTY---HRSPGSTPTTHF-PASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRG 2771
Query: 986 LFKSSRYDP 994
+SR P
Sbjct: 2772 ESTTSRISP 2780
Score = 43.5 bits (101), Expect = 0.002
Identities = 169/853 (19%), Positives = 268/853 (31%), Gaps = 127/853 (14%)
Query: 68 GGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRA 127
G + PES + G RGE + + + + AL P S P +
Sbjct: 837 GSTQTMHFPESDTTSG-----RGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGS 891
Query: 128 PAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRGPLPNHF 187
A P + TA+ S ++A I LP +S++ + + E P+ +
Sbjct: 892 TATTHFPDSSTTSGRSEESTASHSSQDATGTIV--LPARSTTSV--LLGESTTSPISS-- 945
Query: 188 NGRAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNLKTP 247
G E PG++ GL R+ T + P+ L +P
Sbjct: 946 -GSME---------TTALPGSTTTPGLSERS------------TTFHSSPRSPATTL-SP 982
Query: 248 KNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRA 307
+ S G + G+T T + P T G +S + G
Sbjct: 983 ASTTSSGVSEESTTSRSRPGST----------HTTAFPDSTTTPGLSRHSTTSHSSPGST 1032
Query: 308 KLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQ 367
L + P ++ + +G +TA+ T + +T + S +
Sbjct: 1033 DTTLLPASTTTSGPSQESTTSHSSSGST--DTALSPGSTTALSFGQESTTFHSNPGSTHT 1090
Query: 368 ALGPQPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTA 427
L P D T +G + A V + A S S L+ +
Sbjct: 1091 TLFP--------DSTTSSG-----IVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAF 1137
Query: 428 QDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPIS 487
Q P + T PP+ P + S+P S+ G K T S
Sbjct: 1138 QTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPD 1197
Query: 488 SFPCTDLKVSENHKG-CVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGS-ECPSRV 545
+ T G SR + + L G TT P +E S S P+
Sbjct: 1198 ASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTT 1257
Query: 546 LVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPP---QEEVL 602
L S ++S + E S Q + HS VS AS P +E
Sbjct: 1258 L-----------SPASMTSLGVGEESTTSRSQPGSTHS----TVSPASTTTPGLSEESTT 1302
Query: 603 GNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATP 662
S + E E+ ++ + T L E S T S + A P
Sbjct: 1303 VYSSSRGSTETTVFPHSTTTSVHGEEPTTFHSRPASTHTTLFTEDS-TTSGLTEESTAFP 1361
Query: 663 QRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSD---------MEKFTEIIKQMDSAVCM 713
P T T PA+L G + + F SSS + ++ + +
Sbjct: 1362 GSPASTQTG---LPATLTTADLGEESTTFPSSSGSTGTKLSPARSTTSGLVGESTPSRLS 1418
Query: 714 PMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNL 773
P + +P SP P + E K TF + +SPA +
Sbjct: 1419 PSSTETTTLPGSP----TTPSLSE---------KSTTF-YTSPRSPDATLSPATTTSSGV 1464
Query: 774 DTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNGGIKRSRL-EKS 832
+S + + + F T ++ + EP ++ G S L ++S
Sbjct: 1465 SEESSTSHSQPGSTHTTAFPDSTTTSDLSQEPTTSHSSQGSTEATLSPGSTTASSLGQQS 1524
Query: 833 ALFSSL-----LSSLPQDKIFS-------PSVTSV----NTMTTAFSTS----QNGSLSQ 872
F S + LP D I S P+ +S T+T A STS + + Q
Sbjct: 1525 TTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSAGLQEESTTFQ 1584
Query: 873 SSVSQPTTEGAPP 885
S S T +PP
Sbjct: 1585 SWPSSSDTTPSPP 1597
Score = 40.4 bits (93), Expect = 0.015
Identities = 109/511 (21%), Positives = 166/511 (32%), Gaps = 74/511 (14%)
Query: 413 ADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPA 472
A S S L+ + Q P + T PP+ P + S+P S+
Sbjct: 3763 ASSTSPGLQGESTAFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTT 3822
Query: 473 PGDVPKDTCVQSPISSFPCTDLKVSENHKG-CVLPVSRQNNEKMPLLELGGETTPPLSTE 531
G K T S + T G SR + + L G TT P +E
Sbjct: 3823 SGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSE 3882
Query: 532 RSPEAVGS-ECPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVS 590
S S P+ L S ++S + E S Q + HS VS
Sbjct: 3883 ASTTFYSSPRSPTTTL-----------SPASMTSLGVGEESTTSRSQPGSTHS----TVS 3927
Query: 591 VASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPAS------EKTLPIQAQSQGSRTPLM 644
AS P L E + + + V P ++ E+ ++ + T L
Sbjct: 3928 PASTTTPG---LSEESTTVYSSSPGSTETTVFPRSTTTSVRREEPTTFHSRPASTHTTLF 3984
Query: 645 AESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSD-------- 696
E S T S + A P P T T PA+L G + + F SSS
Sbjct: 3985 TEDS-TTSGLTEESTAFPGSPASTQTG---LPATLTTADLGEESTTFPSSSGSTGTKLSP 4040
Query: 697 -MEKFTEIIKQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGK 755
+ ++ + + P + +P SP P + E K TF
Sbjct: 4041 ARSTTSGLVGESTPSRLSPSSTETTTLPGSP----TTPSLSE---------KSTTF-YTS 4086
Query: 756 KKESQPEMSPALHLMQNLDTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKE 815
+ +SPA + +S + + + F T + + EP
Sbjct: 4087 PRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSHSSQGST 4146
Query: 816 NRDVTNGGIKRSRL-EKSALFSSL-----LSSLPQDKIFS-------PSVTSV----NTM 858
++ G S L ++S F S + LP D I S P+ +S T+
Sbjct: 4147 EATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTL 4206
Query: 859 TTAFSTS----QNGSLSQSSVSQPTTEGAPP 885
T A STS + + QS S T +PP
Sbjct: 4207 TPASSTSTGLQEESTTFQSWPSSSDTTPSPP 4237
Score = 38.5 bits (88), Expect = 0.057
Identities = 77/385 (20%), Positives = 132/385 (34%), Gaps = 44/385 (11%)
Query: 346 TVSEEEILPATRGMNGDSSENQALGPQPNQDDKADVQTDAGCLSEPVAS-----ALIPVK 400
T S P ++ S+ +LGP+ T+ L + + A +PV
Sbjct: 693 TASHSSPGPTDTTLSPGSTTASSLGPEYTTFHSRPGSTETTLLPDNTTASGLLEASMPV- 751
Query: 401 DHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAES 460
H + + + S + + T P++ DT+ PPT + S S
Sbjct: 752 -HSSTRSPHTTLSPAGSTTRQGESTTFHSWPSSKDTRPAPPTTTSAFVEPSTTSHGSPSS 810
Query: 461 SPGPSLSLSAPAPGDVPKDTCVQSPISS-----FPCTDL------KVSENHKGCVLPVSR 509
P +S + G V + T S S FP +D + + +H +S
Sbjct: 811 IPTTHISARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISS 870
Query: 510 QNNEKMPLLELGGETTPPLSTERSPEAVG-SECPSRVLVQVRSFVLPV-ESTQDVSSQVI 567
+ L+E P S SP + + P RS S+QD + ++
Sbjct: 871 APSTTSALVE------EPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIV 924
Query: 568 PESSEVREVQLPTCHSNEPEVVSVASCA-PPQEEVLGNEHSHCTAELAAKSGPQVIPPAS 626
+ V L ++ S+ + A P G T + +S + PAS
Sbjct: 925 LPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSERSTTFHSSPRSPATTLSPAS 984
Query: 627 EKTLPIQAQSQGSR----------------TPLMAESSPTNSPSSGNHLATPQRPDQTVT 670
+ + +S SR TP ++ S T+ S G+ T P T T
Sbjct: 985 TTSSGVSEESTTSRSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGS-TDTTLLPASTTT 1043
Query: 671 NGQDSPASLLNISAGSDDSVFDSSS 695
+G ++ + S+GS D+ S
Sbjct: 1044 SGPSQESTTSHSSSGSTDTALSPGS 1068
Score = 35.8 bits (81), Expect = 0.37
Identities = 147/708 (20%), Positives = 237/708 (33%), Gaps = 72/708 (10%)
Query: 15 GSQKSTDSPG---ADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVA 71
GS +T SPG A + PES + E + AS + +P +
Sbjct: 4395 GSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHS------ 4448
Query: 72 SAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRAPAKE 131
S SP + SP +GES + P + T PAPP +
Sbjct: 4449 STGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTT------------PAPPTTTSAFVELS 4496
Query: 132 SPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRGPLPNHFNGRA 191
+ P +P T +A+ + + V SS + P R
Sbjct: 4497 TTSHGSPSSTPTTHFSASSTTLGRSE---ESTTVHSSPVATATTPSPARS---------T 4544
Query: 192 EGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNLKTPKNLD 251
G E +PG++ P ++ GR +T T + H + P
Sbjct: 4545 TSGLVEESTTYHSSPGSTQTMHF-PESNTTSGRGEEST--TSHSSTTHTISS--APSTTS 4599
Query: 252 SLGNEHNPFSQPVHKGNTATK----ISLFENKRTNSSPRHT--DIRGQRNTPASSKTFVG 305
+L E P S G+TAT S + S+ H+ D G PA S T V
Sbjct: 4600 ALVEE--PTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVL 4657
Query: 306 RAKLNLAKKAKEMEQPEKKVMPNSPQN-GVLVKETAIETKVTVSEEEILPATRGMNGDSS 364
+ + + E +P S G+ K T + + + A+ G S
Sbjct: 4658 LGESTTSPISSG--SMETTALPGSTTTPGLSEKSTTFHSSPSSTPTTHFSASSTTLGRSE 4715
Query: 365 ENQALGPQPNQDDKADV---QTDAGCLSEPVASALIPVKDHKLLEKEDSEAA---DSKSL 418
E+ + P T +G + E A P + E S A+ +
Sbjct: 4716 ESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPGSTQTMHFPESSTASGRSEESRT 4775
Query: 419 VLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPK 478
+ T T P+T PT+ + + + P ESS S + A P
Sbjct: 4776 SHSSTTHTISSPPSTTSALVEEPTSYHSSPGSIATTHFP-ESSTTSGRSEESTASHSSP- 4833
Query: 479 DTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLE--LGGETTPPLSTERSPEA 536
DT +P+ + T +++E+ + P S + L ++T S+ RSP+
Sbjct: 4834 DTNGITPLPAHFTTSGRIAESTTFYISPGSMETTLASTATTPGLSAKSTILYSSSRSPDQ 4893
Query: 537 V---GSECPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVAS 593
S S + + S EST + +S + + + T HS + S
Sbjct: 4894 TLSPASMTSSSISGEPTSLYSQAESTHTTAFPASTTTSGLSQ-ESTTFHSKPGSTETTLS 4952
Query: 594 CAPPQEEVLGNE----HSHCTAELAAKS-GPQVIPPASEKTLPIQAQSQGSRTPLMAESS 648
E HS + L+ S +P SE++ + + T + S
Sbjct: 4953 PGSITTSSFAQEFTTPHSQPGSALSTVSPASTTVPGLSEESTTFYSSPGSTETTAFSHS- 5011
Query: 649 PTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSD 696
N+ S + +TP PD PA+L G + + F SSSD
Sbjct: 5012 --NTMSIHSQQSTPF-PDSPGFTHTVLPATLTTTDIGQESTAFHSSSD 5056
Score = 35.0 bits (79), Expect = 0.63
Identities = 64/323 (19%), Positives = 112/323 (34%), Gaps = 43/323 (13%)
Query: 622 IPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLN 681
IP +++ TL S G+ TP T SS + T + PD T T+G ++ ++
Sbjct: 342 IPGSTDTTL-----SPGTTTPSSLGPESTTFHSSPGYTKTTRLPDNTTTSGLLEASTPVH 396
Query: 682 ISAGSDDSVFDSSS------DMEKFTEIIKQMDSAVCMPMKRKKARMPNSPAPHFAMPPI 735
S GS + SS + F D++ P A + S H +
Sbjct: 397 SSTGSPHTTLSPSSSTTHEGEPTTFQSWPSSKDTSPA-PSGTTSAFVKLSTTYHSSPSST 455
Query: 736 HEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLRPKRASAEQSVLFKSL 795
H + LG +ES P S + T + P R++ V +
Sbjct: 456 PTTHF------SASSTTLGHSEESTPVHS------SPVATATTPPPARSATSGHVEESTA 503
Query: 796 HTNTNGNSEPLVMPEIN----DKENRDVTNGGIKRSRLEKSALFSSLLSSLPQDKIFSPS 851
+ + G+++ + PE + E +G ++ + ++L + + S
Sbjct: 504 YHRSPGSTQTMHFPESSTTSGHSEESATFHGSTTHTKSSTPSTTAALAHTSYHSSLGSTE 563
Query: 852 VTSVNTMTTAFSTSQNGSLSQSSVSQPTTEGAP---------------PCGLNKEQSNLL 896
T +T S+ S SS T P P ++ L
Sbjct: 564 TTHFRDSSTISGRSEESKASHSSPDAMATTVLPAGSTPSVLVGDSTPSPISSGSMETTAL 623
Query: 897 PDNSLKVFNFNSSSTSHSSLKSP 919
P ++ K S+T +SS +SP
Sbjct: 624 PGSTTKPGLSEKSTTFYSSPRSP 646
Score = 33.1 bits (74), Expect = 2.4
Identities = 133/653 (20%), Positives = 213/653 (32%), Gaps = 101/653 (15%)
Query: 74 ASPESKPSPGTKGQLRGESDRSKQPPPASSPTKR-------KGRSRALEAVPAPPASGPR 126
+S ++ PSP + + E + P+S+PT GRS V + P +
Sbjct: 4228 SSSDTTPSPPSTTAVPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSPGATGT 4287
Query: 127 A--PAKESPPKRVPDP--SPVTKG---TAAESGEEAARAI----------PRE------- 162
A P + + V +P SP++ G T A G + PR
Sbjct: 4288 ALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSP 4347
Query: 163 LPVKSSSLLPEIKPEHKRGPLPNHFNGRAEG----GRSRELGRAAGAPGASDADGLKPRN 218
SS + E H R P H G S+E + +PG++D L P +
Sbjct: 4348 ASTTSSGVSEESTTSHSR-PGSMHTTAFPSSTTMPGVSQESTASHSSPGSTDTT-LSPGS 4405
Query: 219 HFGVGRSTVTTKVTLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFEN 278
+T T + P E L P N + G S PVH + +L
Sbjct: 4406 TTASSLGPEST--TFHSSPGSTETTL-LPDNTTASGLLEA--STPVHSSTGSPHTTLSPA 4460
Query: 279 KRTNSSPRHTDIRGQRN----TPASSKTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGV 334
T T + N TPA T +L+ P +S G
Sbjct: 4461 GSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGR 4520
Query: 335 LVKETAIETKVTVSEEEILPATRGMNGDSSENQALGPQPNQDDKA---DVQTDAGCLSEP 391
+ T + + + PA +G E+ P + T +G E
Sbjct: 4521 SEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESNTTSGRGEES 4580
Query: 392 VASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTF 451
S H S A + S ++E T + P + T P ++ +
Sbjct: 4581 TTS-------HSSTTHTISSAPSTTSALVEEPT-SYHSSPGSTATTHFPDSSTTSGRSEE 4632
Query: 452 SDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISS--FPCTDLKVSENHKGCVLPVSR 509
S + ++ + G ++ L A + V SPISS T L S G
Sbjct: 4633 STASHSSQDATG-TIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGL------ 4685
Query: 510 QNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVL----VQVRSFVLPVESTQDVSSQ 565
+EK +TP S +G S + V + P ST +S
Sbjct: 4686 --SEKSTTFHSSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARST---TSG 4740
Query: 566 VIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPA 625
++ ES+ T + PE +S A + E HS T +++ PP+
Sbjct: 4741 LVEESTAYHSSPGSTQTMHFPE----SSTASGRSEESRTSHSSTTHTISS-------PPS 4789
Query: 626 SEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPAS 678
+ L PT+ SS +AT P+ + T+G+ ++
Sbjct: 4790 TTSALV---------------EEPTSYHSSPGSIATTHFPESSTTSGRSEEST 4827
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 56.2 bits (134), Expect = 3e-07
Identities = 91/414 (21%), Positives = 149/414 (35%), Gaps = 60/414 (14%)
Query: 316 KEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEE-----------ILPATR------- 357
K + PE+K+ N P K+ + SEEE +PA R
Sbjct: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
Query: 358 --GMNGDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAAD- 414
+SS ++ +++D+ G + A+ P K DS + D
Sbjct: 119 AAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDE 178
Query: 415 ---SKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAP 471
++ + VT AQ + P A K + S S S + S +A
Sbjct: 179 PPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAAT 238
Query: 472 APGDVPKDTCV-QSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGG--ETTPPL 528
VPK V ++P+ + K S + + +K P+ G + PP
Sbjct: 239 PKKTVPKKQVVAKAPVKAATTPTRKSSSSEDS---SSDEEEEQKKPMKNKPGPYSSVPPP 295
Query: 529 STERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEV 588
S +++G++ P + + + + PVES++D S + +SS E + PT V
Sbjct: 296 SAPPPKKSLGTQPPKKAVEKQQ----PVESSEDSSDE--SDSSSEEEKKPPT-----KAV 344
Query: 589 VSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESS 648
VS A+ PP + S + +++ PA S P + S
Sbjct: 345 VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAG-------TTKNSSNKPAVTTKS 397
Query: 649 PTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFTE 702
P P++ P Q V GQ LL A S S +SSS E+ T+
Sbjct: 398 PAVKPAAA--------PKQPVGGGQ----KLLTRKADSSSSEEESSSSEEEKTK 439
Score = 41.2 bits (95), Expect = 0.009
Identities = 98/494 (19%), Positives = 176/494 (35%), Gaps = 77/494 (15%)
Query: 27 AELPESAARDDAVFDDEVAPNAAS----DNASAEKKVKSP----------RAALDGGVAS 72
A++PE + + + A+S D++ E++V+ P R L G A+
Sbjct: 61 AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA 120
Query: 73 AASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRAPAKES 132
A + ES S + E D+ KQP +KG P+A A ++
Sbjct: 121 AKASESSSSEESSDD-DDEEDQKKQP-------VQKGVK-------------PQAKAAKA 159
Query: 133 PPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRGPLPNHFNGRAE 192
PPK+ S + ++ E P+ PV +K + K P P +
Sbjct: 160 PPKKA--KSSDSDSDSSSEDEPPKNQKPKITPV-------TVKAQTKAPPKPARAAPKIA 210
Query: 193 GGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNLK---TPKN 249
G++ ++ + +SD + ++ T K T+P K + +K TP
Sbjct: 211 NGKAASSSSSSSSSSSSDDSEEE--------KAAATPKKTVPKKQVVAKAPVKAATTPTR 262
Query: 250 LDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKL 309
S + + + K K + + S+P G T K + +
Sbjct: 263 KSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLG---TQPPKKAVEKQQPV 319
Query: 310 NLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQAL 369
++ + + + P V+ K T TK +++ ++ + DSSE+
Sbjct: 320 ESSEDSSDESDSSSEEEKKPPTKAVVSKAT---TKPPPAKKAAESSSDSSDSDSSEDDEA 376
Query: 370 GPQP-----NQDDKADVQTDAGCLSEPVASALIPV-KDHKLLEKE------DSEAADSKS 417
+P N +K V T + + +P A+ PV KLL ++ + E++ S+
Sbjct: 377 PSKPAGTTKNSSNKPAVTTKSPAV-KPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEE 435
Query: 418 LVLENVTDTAQDIPTTVDTKDLPPTAMP---KPQHTFSDSQSPAESSPGPSLSLSAPAPG 474
+ + T + T LP P + + SDS S E S S P
Sbjct: 436 EKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQ 495
Query: 475 DVPKDTCVQSPISS 488
V P S+
Sbjct: 496 KVAGGAAPSKPASA 509
Score = 35.4 bits (80), Expect = 0.48
Identities = 96/456 (21%), Positives = 161/456 (35%), Gaps = 75/456 (16%)
Query: 267 GNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLA--KKAKEMEQPEKK 324
G A K S E+ + S D Q+ P K +AK A KKAK +
Sbjct: 117 GKAAAKAS--ESSSSEESSDDDDEEDQKKQPVQ-KGVKPQAKAAKAPPKKAKSSDSDSDS 173
Query: 325 VMPNSPQNGVLVKETAIETKVTVSE--EEILPATRGMNGDSSENQALGPQPNQDDKADVQ 382
+ P K T + K + A + NG ++ + + + D ++ +
Sbjct: 174 SSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEE 233
Query: 383 TDAGCLSEPVAS----ALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKD 438
A + V A PVK ++ S + DS S D ++
Sbjct: 234 KAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSS-----------------DEEE 276
Query: 439 LPPTAMPKPQHTFSDSQSPAESSPGPSLSL---SAPAPGD----------VPKDTCVQSP 485
+ + P ++ PGP S+ SAP P V K V+S
Sbjct: 277 --------------EQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESS 322
Query: 486 ISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRV 545
S +D E K V + K P + E++ S S E E PS+
Sbjct: 323 EDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSE--DDEAPSK- 379
Query: 546 LVQVRSFVLPVESTQDVSSQ--VIPESSEVREVQLP--TCHSNEPEVVSVASCAPPQEEV 601
P +T++ S++ V +S V+ P + + A + +EE
Sbjct: 380 ---------PAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEES 430
Query: 602 LGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSR-TPLMAESSPTNSPSSGNHLA 660
+E T ++ A + P+ A+ +LP + QGSR + ++SS + +
Sbjct: 431 SSSEEEK-TKKMVATTKPKATAKAA-LSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKS 488
Query: 661 TPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSD 696
++ Q V G +P+ + G +S SSSD
Sbjct: 489 AVKKKPQKVAGGA-APSKPASAKKGKAESSNSSSSD 523
Score = 34.7 bits (78), Expect = 0.82
Identities = 42/185 (22%), Positives = 75/185 (40%), Gaps = 22/185 (11%)
Query: 19 STDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGG---VASAAS 75
+T P A A+ S A + + + ++S E++ K+ ++A+ VA A+
Sbjct: 443 ATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAA 502
Query: 76 PESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRA-------P 128
P SKP+ KG + ES S +S + K + + AP A+G A
Sbjct: 503 P-SKPASAKKG--KAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKA 559
Query: 129 AKESPPKR---------VPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHK 179
AK S + V + K E+ +EA +++ +++ + P+ K K
Sbjct: 560 AKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEK 619
Query: 180 RGPLP 184
R P
Sbjct: 620 RASSP 624
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 56.2 bits (134), Expect = 3e-07
Identities = 45/183 (24%), Positives = 80/183 (43%), Gaps = 12/183 (6%)
Query: 10 SGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGG 69
S + G Q+ ++ A+AE E+ A+++ +++ A + A+ KV+ P A
Sbjct: 559 SEKEEGEQEEGETE-AEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPV 617
Query: 70 VASAASPESK-PSPGTKGQLRGESDRSKQP-------PPASSPTKRKGRSRALEAVPAPP 121
S + K P P + + +G+S K P P SP + KG+S ++ P
Sbjct: 618 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS---PV 674
Query: 122 ASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRG 181
++P +SP + + V KG E E+ + P+E V+ P+ PE K+
Sbjct: 675 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 734
Query: 182 PLP 184
P
Sbjct: 735 ESP 737
Score = 34.3 bits (77), Expect = 1.1
Identities = 79/370 (21%), Positives = 125/370 (33%), Gaps = 61/370 (16%)
Query: 54 SAEKKVKSPRA-----ALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRK 108
+AE+K + P A A A +PE K G K + G+ + ++ A S +
Sbjct: 491 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550
Query: 109 GRSRAL-----------EAVPAPPASGPRAPAKESPP-----------------KRVPDP 140
G S E A G A AKE +V P
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610
Query: 141 ----SPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHK-RGPLPN---HFNGRAE 192
SPV K E G+ P E K S +P+ E K + P+P G++
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVE--EKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 668
Query: 193 GGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKH--VELNLKTPKNL 250
+S +A S + K + G G + + PK VE + PK++
Sbjct: 669 VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDV 728
Query: 251 DSLGNEHNPFSQ----PVHKGNTATKISLFENKRTNSSPRHTDI-------RGQRNTPAS 299
+P + V + K+ L + + P + G S
Sbjct: 729 PEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGS 788
Query: 300 SKTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGM 359
K G K ++A E+E E +V + + G +E E V + ++ PA
Sbjct: 789 DKGAKGSRKEDIAVNG-EVEGKE-EVEQETKEKGSGREE---EKGVVTNGLDLSPADEKK 843
Query: 360 NGDSSENQAL 369
GD SE + +
Sbjct: 844 GGDKSEEKVV 853
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 56.2 bits (134), Expect = 3e-07
Identities = 45/183 (24%), Positives = 80/183 (43%), Gaps = 12/183 (6%)
Query: 10 SGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGG 69
S + G Q+ ++ A+AE E+ A+++ +++ A + A+ KV+ P A
Sbjct: 183 SEKEEGEQEEGETE-AEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPV 241
Query: 70 VASAASPESK-PSPGTKGQLRGESDRSKQP-------PPASSPTKRKGRSRALEAVPAPP 121
S + K P P + + +G+S K P P SP + KG+S ++ P
Sbjct: 242 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS---PV 298
Query: 122 ASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRG 181
++P +SP + + V KG E E+ + P+E V+ P+ PE K+
Sbjct: 299 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358
Query: 182 PLP 184
P
Sbjct: 359 ESP 361
Score = 34.3 bits (77), Expect = 1.1
Identities = 79/370 (21%), Positives = 125/370 (33%), Gaps = 61/370 (16%)
Query: 54 SAEKKVKSPRA-----ALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRK 108
+AE+K + P A A A +PE K G K + G+ + ++ A S +
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
Query: 109 GRSRAL-----------EAVPAPPASGPRAPAKESPP-----------------KRVPDP 140
G S E A G A AKE +V P
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
Query: 141 ----SPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHK-RGPLPN---HFNGRAE 192
SPV K E G+ P E K S +P+ E K + P+P G++
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVE--EKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 292
Query: 193 GGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKH--VELNLKTPKNL 250
+S +A S + K + G G + + PK VE + PK++
Sbjct: 293 VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDV 352
Query: 251 DSLGNEHNPFSQ----PVHKGNTATKISLFENKRTNSSPRHTDI-------RGQRNTPAS 299
+P + V + K+ L + + P + G S
Sbjct: 353 PEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGS 412
Query: 300 SKTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGM 359
K G K ++A E+E E +V + + G +E E V + ++ PA
Sbjct: 413 DKGAKGSRKEDIAVNG-EVEGKE-EVEQETKEKGSGREE---EKGVVTNGLDLSPADEKK 467
Query: 360 NGDSSENQAL 369
GD SE + +
Sbjct: 468 GGDKSEEKVV 477
>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
Length = 653
Score = 55.8 bits (133), Expect = 3e-07
Identities = 61/225 (27%), Positives = 85/225 (37%), Gaps = 20/225 (8%)
Query: 5 SSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNA-SAEKKVKSPR 63
S GRRS R S S+ SP + +S + ++P + + ++ R
Sbjct: 247 SPGRRSHRH--SSGSSHSPSLSSHYSDSRS------PSRLSPKHRDEGRKTGSQRSSGSR 298
Query: 64 AALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPP--ASSPTKRKGRSRALEAVPAPP 121
+ G + SP+ G + G S PP SSP+ R R +A A P PP
Sbjct: 299 SPSPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPSSPSPRV-RDKAAAAAPTPP 357
Query: 122 ASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRG 181
A G KESP R S G AA R R +SS+ P + +
Sbjct: 358 ARG-----KESPSPRSAPSSQGRGGRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPR 412
Query: 182 PLPNHFNGR--AEGGRSRELGRAAGAPGASDADGLKPRNHFGVGR 224
P P + R + S + G GAPG G R H G G+
Sbjct: 413 PAPPRGSSRSLSRARSSSDSGSGRGAPGPGPEPG-SERGHGGHGK 456
Score = 43.5 bits (101), Expect = 0.002
Identities = 47/197 (23%), Positives = 74/197 (37%), Gaps = 23/197 (11%)
Query: 6 SGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAA 65
+GRR RRR ++S S A P R P A S+ + + R++
Sbjct: 383 AGRRRRRRRRRRRSRSSASA----PRRRGRR--------RPRPAPPRGSS-RSLSRARSS 429
Query: 66 LDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGP 125
D G A P P PG++ G R+K+ PP R+R P+P A G
Sbjct: 430 SDSGSGRGA-PGPGPEPGSERGHGGHGKRAKERPP---------RARPASTSPSPGAHGR 479
Query: 126 RAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRGPLPN 185
R + R P P P + ++ + +R+ + S S P+ +
Sbjct: 480 RGGPEGKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGR 539
Query: 186 HFNGRAEGGRSRELGRA 202
+ AE R+R R+
Sbjct: 540 ARHSEAEATRARRRSRS 556
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,667,843
Number of Sequences: 37866
Number of extensions: 3848790
Number of successful extensions: 21318
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 124
Number of HSP's successfully gapped in prelim test: 1025
Number of HSP's that attempted gapping in prelim test: 15764
Number of HSP's gapped (non-prelim): 5046
length of query: 1723
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1607
effective length of database: 13,855,062
effective search space: 22265084634
effective search space used: 22265084634
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.