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Search of human proteins with 5031999
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031999 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 4 isoform a [Homo sapiens]
(359 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031999 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransf... 728 0.0
gi|5174677 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransf... 427 e-120
gi|28373099 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltrans... 332 2e-91
gi|110815855 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltran... 219 2e-57
gi|28373101 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltrans... 165 7e-41
gi|4506953 alpha-2,8-sialyltransferase 1 [Homo sapiens] 157 2e-38
gi|54234057 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltrans... 151 8e-37
gi|27765096 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [... 82 1e-15
gi|4506951 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [H... 82 1e-15
gi|5902082 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [H... 78 1e-14
gi|21264332 sialyltransferase 7A [Homo sapiens] 72 1e-12
gi|5454058 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [H... 69 8e-12
gi|192448440 sialyltransferase 7B [Homo sapiens] 67 3e-11
gi|109633046 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ... 66 6e-11
gi|109633044 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ... 66 6e-11
gi|13569938 sialyltransferase 7E [Homo sapiens] 65 7e-11
gi|28373092 sialyltransferase 7D isoform a [Homo sapiens] 65 9e-11
gi|4506949 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 i... 60 3e-09
gi|27765091 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 ... 60 3e-09
gi|5174697 alpha2,3-sialyltransferase VI [Homo sapiens] 59 5e-09
gi|28373086 sialyltransferase 6 isoform i [Homo sapiens] 58 1e-08
gi|28373082 sialyltransferase 6 isoform g [Homo sapiens] 58 1e-08
gi|28373078 sialyltransferase 6 isoform f [Homo sapiens] 58 1e-08
gi|28373070 sialyltransferase 6 isoform b [Homo sapiens] 58 1e-08
gi|28373068 sialyltransferase 6 isoform a [Homo sapiens] 58 1e-08
gi|5454060 sialyltransferase 6 isoform j [Homo sapiens] 58 1e-08
gi|215272345 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2... 56 4e-08
gi|26190610 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 ... 56 4e-08
gi|215272347 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2... 53 5e-07
gi|28373074 sialyltransferase 6 isoform d [Homo sapiens] 51 1e-06
>gi|5031999 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 4 isoform a [Homo sapiens]
Length = 359
Score = 728 bits (1879), Expect = 0.0
Identities = 359/359 (100%), Positives = 359/359 (100%)
Query: 1 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG 60
MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
Sbjct: 1 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG 60
Query: 61 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI 120
SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
Sbjct: 61 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI 120
Query: 121 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD 180
SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD
Sbjct: 121 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD 180
Query: 181 VGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV 240
VGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV
Sbjct: 181 VGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV 240
Query: 241 NALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF 300
NALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF
Sbjct: 241 NALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF 300
Query: 301 WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ 359
WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
Sbjct: 301 WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ 359
>gi|5174677 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 2 [Homo sapiens]
Length = 375
Score = 427 bits (1099), Expect = e-120
Identities = 211/371 (56%), Positives = 267/371 (71%), Gaps = 25/371 (6%)
Query: 6 KRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNS-------------- 51
+ W + ++LL++F +I+ EE ++ G RS VNS
Sbjct: 6 RSWMLAALTLLVVFLIFADISEIEE----EIGNSGGRGTIRSAVNSLHSKSNRAEVVING 61
Query: 52 --SDKIIRKAGSSIFQHNVEG----WKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPG 105
S ++ ++ SI +HN++ W+ N +L L IRK IL+FLDAE+D+SV+K + KPG
Sbjct: 62 SSSPAVVDRSNESI-KHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPG 120
Query: 106 DVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNF 165
D+IHY+ DR T+N+S +L+ LLP SP+KN+ F TCA+VGNSG+LL+S CG+EID+H+F
Sbjct: 121 DIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSF 180
Query: 166 VIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWI 225
VIRCNLAPV E+A DVG K+D +TMNPSV+QRAF N + REK + RL LN S+LWI
Sbjct: 181 VIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWI 240
Query: 226 PAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMY 285
PAFM +GG++ VEWVN LILK+ + VRTAYPSLRL+HAVRGYWLTNKV IKRP+TGLLMY
Sbjct: 241 PAFMARGGKERVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMY 300
Query: 286 TLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHN 345
TLATRFC +I+LYGFWPFP D N VKYHYYD LKY Y S ASPH MPLEFK L LH
Sbjct: 301 TLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHE 360
Query: 346 RGALKLTTGKC 356
+GALKLT G+C
Sbjct: 361 QGALKLTVGQC 371
>gi|28373099 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 4 isoform b [Homo sapiens]
Length = 168
Score = 332 bits (852), Expect = 2e-91
Identities = 168/168 (100%), Positives = 168/168 (100%)
Query: 1 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG 60
MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
Sbjct: 1 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG 60
Query: 61 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI 120
SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
Sbjct: 61 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI 120
Query: 121 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIR 168
SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIR
Sbjct: 121 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIR 168
>gi|110815855 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 3 [Homo sapiens]
Length = 380
Score = 219 bits (559), Expect = 2e-57
Identities = 116/297 (39%), Positives = 170/297 (57%), Gaps = 6/297 (2%)
Query: 65 QHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRR-TLNISHD 123
Q WK N + L R+ IL+ +D ++ S+ K+S + G ++HY + +IS++
Sbjct: 84 QEKPSKWKFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNN 143
Query: 124 LHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGT 183
SLLP+VSP+ N+ + CAVVGNSGIL S+CG+EID +FV RCN AP F DVG
Sbjct: 144 FRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGR 203
Query: 184 KSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNAL 243
K++ T NPS++++ + DR F L L+ ++LWIPAF +
Sbjct: 204 KTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDF 263
Query: 244 ILKNK--LKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFW 301
++++ LKV+ A+P ++ V YW + KR STG+LMYTLA+ C+EIHLYGFW
Sbjct: 264 FVEHRGQLKVQLAWPG-NIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFW 322
Query: 302 PFPKDLNGKA-VKYHYYDDLKYRYFSN-ASPHRMPLEFKTLNVLHNRGALKLTTGKC 356
PF D N + + YHYYD ++ + H++P EF+ L +H G KLT C
Sbjct: 323 PFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHC 379
>gi|28373101 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 5 [Homo sapiens]
Length = 376
Score = 165 bits (417), Expect = 7e-41
Identities = 96/287 (33%), Positives = 150/287 (52%), Gaps = 7/287 (2%)
Query: 71 WKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPE 130
W +N S + + + R +A + + + G + Y +D +I+ ++ + P+
Sbjct: 93 WAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPK 152
Query: 131 VSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVE-FAADVGTKSDFIT 189
P +FK CAVVGN GIL +S CG+EI+S +FV RCNL P+ E + DVG K+D +T
Sbjct: 153 DMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVT 212
Query: 190 MNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKL 249
+NPS++ F + E R F L + ++ + +PAF V ++ +
Sbjct: 213 VNPSIITERF--HKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFES 270
Query: 250 KVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNG 309
Y + + V YWL+ V KR STGL++ T A C+E+HL+GFW FP + +G
Sbjct: 271 PQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSG 330
Query: 310 KAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKC 356
+ +HYYD++K R H MP E LH+RG L++ TG C
Sbjct: 331 LYITHHYYDNVKPR----PGFHAMPSEIFNFLHLHSRGILRVHTGTC 373
>gi|4506953 alpha-2,8-sialyltransferase 1 [Homo sapiens]
Length = 356
Score = 157 bits (396), Expect = 2e-38
Identities = 92/288 (31%), Positives = 149/288 (51%), Gaps = 10/288 (3%)
Query: 71 WKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPE 130
W+ N + RK + D ++ K + G + Y + + I + +SL P+
Sbjct: 68 WRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQ 127
Query: 131 VSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVV-EFAADVGTKSDFIT 189
+P + K CAVVGN GIL S CG++ID NFV+RCNL P+ E+ DVG+KS +T
Sbjct: 128 ATPFQ-LPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGSKSQLVT 186
Query: 190 MNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKL 249
NPS++++ F R+ FV + + N S +++PAF +K G + V +
Sbjct: 187 ANPSIIRQRFQNLL--WSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLSDVGA 244
Query: 250 KVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNG 309
+ + + ++ +W + + KR STGL + + A C+E+ +YGFWPF +++
Sbjct: 245 NQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHE 304
Query: 310 KAVKYHYYDD-LKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKC 356
+ + +HYYD+ L + F H MP EF L LH GAL++ C
Sbjct: 305 QPISHHYYDNVLPFSGF-----HAMPEEFLQLWYLHKIGALRMQLDPC 347
>gi|54234057 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 6 [Homo sapiens]
Length = 398
Score = 151 bits (382), Expect = 8e-37
Identities = 84/287 (29%), Positives = 146/287 (50%), Gaps = 7/287 (2%)
Query: 71 WKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPE 130
WK + R + DA ++ V +++ G + Y ++ ++ + I ++ + P
Sbjct: 115 WKRQAEEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPV 174
Query: 131 VSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVV-EFAADVGTKSDFIT 189
P + + CAVVGN GIL S CG EID +FV RCNL P + + DVG+K++ +T
Sbjct: 175 SQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVT 234
Query: 190 MNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKL 249
+NPS++ +G + + + F+ ++ D+ +PAF + V + ++K
Sbjct: 235 INPSIITLKYGNLKEK--KALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKA 292
Query: 250 KVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNG 309
+ + + + + + +W T V R STGL++ ++A C + LYGFWPF K +
Sbjct: 293 RQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVED 352
Query: 310 KAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKC 356
V +HYYD+ ++ H+MP E+ + LH +G LKL KC
Sbjct: 353 IPVSHHYYDNKLPKH----GFHQMPKEYSQILQLHMKGILKLQFSKC 395
>gi|27765096 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
[Homo sapiens]
Length = 340
Score = 81.6 bits (200), Expect = 1e-15
Identities = 66/202 (32%), Positives = 95/202 (47%), Gaps = 22/202 (10%)
Query: 123 DLHSLLP-EVSPMKNRRF---KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFA 178
+L ++P V PM +R + CAVVGNSG L +S G EIDSH+FV+R N AP F
Sbjct: 119 ELFRVVPGNVDPMLEKRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFE 178
Query: 179 ADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVE 238
ADVGTK+ + P FR D + + + W+ + + G H
Sbjct: 179 ADVGTKTTHHLVYPE-------SFRELGDNVSMI-LVPFKTIDLEWVVSAITTGTISHTY 230
Query: 239 W-VNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHL 297
V A I + K+ +P+ I V WL + PSTG+L + CDE+ L
Sbjct: 231 IPVPAKIRVKQDKILIYHPA--FIKYVFDNWLQGHG--RYPSTGILSVIFSMHVCDEVDL 286
Query: 298 YGFWPFPKDLNGKAVKYHYYDD 319
YGF + K +HY+++
Sbjct: 287 YGF-----GADSKGNWHHYWEN 303
>gi|4506951 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [Homo
sapiens]
Length = 340
Score = 81.6 bits (200), Expect = 1e-15
Identities = 66/202 (32%), Positives = 95/202 (47%), Gaps = 22/202 (10%)
Query: 123 DLHSLLP-EVSPMKNRRF---KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFA 178
+L ++P V PM +R + CAVVGNSG L +S G EIDSH+FV+R N AP F
Sbjct: 119 ELFRVVPGNVDPMLEKRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFE 178
Query: 179 ADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVE 238
ADVGTK+ + P FR D + + + W+ + + G H
Sbjct: 179 ADVGTKTTHHLVYPE-------SFRELGDNVSMI-LVPFKTIDLEWVVSAITTGTISHTY 230
Query: 239 W-VNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHL 297
V A I + K+ +P+ I V WL + PSTG+L + CDE+ L
Sbjct: 231 IPVPAKIRVKQDKILIYHPA--FIKYVFDNWLQGHG--RYPSTGILSVIFSMHVCDEVDL 286
Query: 298 YGFWPFPKDLNGKAVKYHYYDD 319
YGF + K +HY+++
Sbjct: 287 YGF-----GADSKGNWHHYWEN 303
>gi|5902082 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [Homo
sapiens]
Length = 350
Score = 77.8 bits (190), Expect = 1e-14
Identities = 65/243 (26%), Positives = 112/243 (46%), Gaps = 22/243 (9%)
Query: 117 TLNISHDLHSLLPEVSPMKNR---RFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAP 173
T + L ++P +P + R + + CAVVGNSG L S G+++D HNF++R N AP
Sbjct: 124 TNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAP 183
Query: 174 VVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGG 233
V F DVG+++ M P +N FV + D +LWI + + G
Sbjct: 184 TVGFEQDVGSRTTHHFMYPE-------SAKNLPANVSFVLVPFKVLD-LLWIASALSTGQ 235
Query: 234 EKHV-EWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFC 292
+ V + + +K KV+ P+ + W + + PSTG+L+ A C
Sbjct: 236 IRFTYAPVKSFLRVDKEKVQIYNPA--FFKYIHDRWTEHHG--RYPSTGMLVLFFALHVC 291
Query: 293 DEIHLYGFWPFPKDLNGKAVKYHYYDDLKYR-YFSNASPHRMPLEFKTLNVLHNRGALKL 351
DE+++YGF + + +HY+++ +Y F H E +++L +++
Sbjct: 292 DEVNVYGF-----GADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEV 346
Query: 352 TTG 354
G
Sbjct: 347 YRG 349
>gi|21264332 sialyltransferase 7A [Homo sapiens]
Length = 600
Score = 71.6 bits (174), Expect = 1e-12
Identities = 68/245 (27%), Positives = 111/245 (45%), Gaps = 39/245 (15%)
Query: 133 PMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDF----- 187
P + R TCAVVGN GIL +S G+EIDSH++V R + A + + DVGT++ F
Sbjct: 356 PAGSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTA 415
Query: 188 ITMNPSVVQRAFGGFRNE--SDREKFVHRLSMLNDSVLWIPAFMVKGG--EKHVEWV--- 240
++ S++ GF+N +++H L D W+ A ++ K++ W
Sbjct: 416 FSLTQSLLILGNRGFKNVPLGKDVRYLHFLEGTRD-YEWLEALLMNQTVMSKNLFWFRHR 474
Query: 241 ------NALILKNKLKVRTAYPSLRLIHAVRGYWLTNKV------PIKRPSTGLLMYTLA 288
AL + L + + + ++ +L +K I RP+TG L+ A
Sbjct: 475 PQEAFREALHMDRYLLLHPDF-----LRYMKNRFLRSKTLDGAHWRIYRPTTGALLLLTA 529
Query: 289 TRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYR--YFSNASPHRMPLEFKTLNVLHNR 346
+ CD++ YGF + HYYD R ++ N H LE + LH+
Sbjct: 530 LQLCDQVSAYGF----ITEGHERFSDHYYDTSWKRLIFYIN---HDFKLEREVWKRLHDE 582
Query: 347 GALKL 351
G ++L
Sbjct: 583 GIIRL 587
>gi|5454058 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [Homo
sapiens]
Length = 329
Score = 68.6 bits (166), Expect = 8e-12
Identities = 64/228 (28%), Positives = 104/228 (45%), Gaps = 16/228 (7%)
Query: 134 MKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPS 193
+++ R + C VVGN L +S G I+ ++ VIR N APV + DVG+K+ TM
Sbjct: 108 IQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKT---TMRLF 164
Query: 194 VVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVE---WVNALIL--KNK 248
+ A + E++ + + ++ WI + +K V W ++ N
Sbjct: 165 YPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETIL--SDKKRVRKGFWKQPPLIWDVNP 222
Query: 249 LKVRTAYPSLRLIHAVRGYWLTNKVPIK---RPSTGLLMYTLATRFCDEIHLYGFWPFPK 305
++R P I A + L + P K +P+TGLL TLA CD +H+ GF +P
Sbjct: 223 KQIRILNPFFMEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGF-GYP- 280
Query: 306 DLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTT 353
D K HYY+ + + + S H + E + + GA+K T
Sbjct: 281 DAYNKKQTIHYYEQITLKSMA-GSGHNVSQEALAIKRMLEMGAIKNLT 327
>gi|192448440 sialyltransferase 7B [Homo sapiens]
Length = 374
Score = 66.6 bits (161), Expect = 3e-11
Identities = 68/236 (28%), Positives = 98/236 (41%), Gaps = 41/236 (17%)
Query: 142 CAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFI-----TMNPSVVQ 196
CAVVGN GIL S G ID+H++V R N A + F DVGTK+ F TM S+V
Sbjct: 151 CAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVS 210
Query: 197 RAFGGFRNESDREKF--------VHRLSMLNDSVLWIPA--FMVKGGEKHVEWVNALILK 246
GF + + + ML ++L +P + KG H +
Sbjct: 211 YWNLGFTSVPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPE---A 267
Query: 247 NKLKVRTAYPSLRLIHAVRGYWLTNKV------PIKRPSTGLLMYTLATRFCDEIHLYGF 300
+ K + +P I + +L +K+ + PSTG LM A CD++ YGF
Sbjct: 268 SASKFKLLHPD--FISYLTERFLKSKLINTHFGDLYMPSTGALMLLTALHTCDQVSAYGF 325
Query: 301 -----WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKL 351
W F HY+ + K + + H + LE LH G L+L
Sbjct: 326 ITSNYWKFSD---------HYF-ERKMKPLIFYANHDLSLEAALWRDLHKAGILQL 371
>gi|109633046 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
isoform 2 [Homo sapiens]
Length = 395
Score = 65.9 bits (159), Expect = 6e-11
Identities = 66/250 (26%), Positives = 100/250 (40%), Gaps = 30/250 (12%)
Query: 124 LHSLLPEVSPMKNRRFKTC---AVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD 180
L LLPE ++ + KTC V+G+ GIL E G ++ + VIR N APV ++
Sbjct: 151 LLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEH 210
Query: 181 VGTKSDFITMNPSVVQRA---------FGGFRNESDREKFVHRLSMLNDSVLWIPAFMVK 231
VG K+ P + F +S ++ + W+ F K
Sbjct: 211 VGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWK 270
Query: 232 G-------GEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLM 284
KH +N +I+K TA+ L+ +W +K P+ G++
Sbjct: 271 QVAEKIPLQPKHFRILNPVIIK-----ETAFDILQYSEPQSRFWGRDK---NVPTIGVIA 322
Query: 285 YTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLH 344
LAT CDE+ L G F DLN HY+D + + H + E K L L
Sbjct: 323 VVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLV 379
Query: 345 NRGALKLTTG 354
G +K +G
Sbjct: 380 KEGVVKDLSG 389
>gi|109633044 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
isoform 1 [Homo sapiens]
Length = 418
Score = 65.9 bits (159), Expect = 6e-11
Identities = 66/250 (26%), Positives = 100/250 (40%), Gaps = 30/250 (12%)
Query: 124 LHSLLPEVSPMKNRRFKTC---AVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD 180
L LLPE ++ + KTC V+G+ GIL E G ++ + VIR N APV ++
Sbjct: 174 LLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEH 233
Query: 181 VGTKSDFITMNPSVVQRA---------FGGFRNESDREKFVHRLSMLNDSVLWIPAFMVK 231
VG K+ P + F +S ++ + W+ F K
Sbjct: 234 VGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWK 293
Query: 232 G-------GEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLM 284
KH +N +I+K TA+ L+ +W +K P+ G++
Sbjct: 294 QVAEKIPLQPKHFRILNPVIIK-----ETAFDILQYSEPQSRFWGRDK---NVPTIGVIA 345
Query: 285 YTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLH 344
LAT CDE+ L G F DLN HY+D + + H + E K L L
Sbjct: 346 VVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLV 402
Query: 345 NRGALKLTTG 354
G +K +G
Sbjct: 403 KEGVVKDLSG 412
>gi|13569938 sialyltransferase 7E [Homo sapiens]
Length = 336
Score = 65.5 bits (158), Expect = 7e-11
Identities = 57/193 (29%), Positives = 82/193 (42%), Gaps = 27/193 (13%)
Query: 140 KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAF 199
+ CA+V +SG LL S G +ID VIR N AP + DVG ++ + S +QR
Sbjct: 94 RDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRI- 152
Query: 200 GGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLR 259
RN D + +S + W P+ ++ K + N +L L P L+
Sbjct: 153 --LRNRHD----LLNVSQGTVFIFWGPSSYMRRDGKGQVYNNLHLLSQVL------PRLK 200
Query: 260 LIHAVRGYWL------------TNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWP--FPK 305
R L K+ STG T+A CD I++YG P F +
Sbjct: 201 AFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVYGMVPPDFCR 260
Query: 306 DLNGKAVKYHYYD 318
D N +V YHYY+
Sbjct: 261 DPNHPSVPYHYYE 273
>gi|28373092 sialyltransferase 7D isoform a [Homo sapiens]
Length = 302
Score = 65.1 bits (157), Expect = 9e-11
Identities = 67/245 (27%), Positives = 106/245 (43%), Gaps = 33/245 (13%)
Query: 125 HSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
+S +P+ P+ ++CAVV +SG +L S G EIDS V R N AP V F ADVG +
Sbjct: 59 YSSVPDGKPLVREPCRSCAVVSSSGQMLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQR 118
Query: 185 SDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV-NAL 243
S ++ + V RN S H D++ +MV G +H++ V
Sbjct: 119 STLRVVSHTSVPLL---LRNYS------HYFQKARDTL-----YMVWGQGRHMDRVLGGR 164
Query: 244 ILKNKLKVRTAYPSLRL------IHAVRGYWLTNKVPIKRP------STGLLMYTLATRF 291
+ L++ YP L++ + A ++ R STG LA
Sbjct: 165 TYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALEL 224
Query: 292 CDEIHLYGFW--PFPKDLNGKAVKYHYYD----DLKYRYFSNASPHRMPLEFKTLNVLHN 345
C+EI +YG + ++ + +V YHY++ D Y ++ R F T + +
Sbjct: 225 CEEIVVYGMVSDSYCREKSHPSVPYHYFEKGRLDECQMYLAHEQAPRSAHRFITEKAVFS 284
Query: 346 RGALK 350
R A K
Sbjct: 285 RWAKK 289
>gi|4506949 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
isoform a [Homo sapiens]
Length = 406
Score = 60.1 bits (144), Expect = 3e-09
Identities = 50/194 (25%), Positives = 82/194 (42%), Gaps = 40/194 (20%)
Query: 142 CAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGG 201
CAVV ++G L S+ G+EID H+ V+R N AP F DVGTK+ MN +V
Sbjct: 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV------ 237
Query: 202 FRNESDREKFVHRLSMLNDSVL--WIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLR 259
EK + S+ N+ +L W P+ K + + N Y + R
Sbjct: 238 -----TTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNN-------YKTYR 285
Query: 260 LIHAVRGYWL-----------------TNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWP 302
+H + +++ ++ PS+G+L + CD++ +Y F P
Sbjct: 286 KLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLP 345
Query: 303 FPKDLNGKAVKYHY 316
+ + V Y+Y
Sbjct: 346 SKRKTD---VCYYY 356
>gi|27765091 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
isoform a [Homo sapiens]
Length = 406
Score = 60.1 bits (144), Expect = 3e-09
Identities = 50/194 (25%), Positives = 82/194 (42%), Gaps = 40/194 (20%)
Query: 142 CAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGG 201
CAVV ++G L S+ G+EID H+ V+R N AP F DVGTK+ MN +V
Sbjct: 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV------ 237
Query: 202 FRNESDREKFVHRLSMLNDSVL--WIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLR 259
EK + S+ N+ +L W P+ K + + N Y + R
Sbjct: 238 -----TTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNN-------YKTYR 285
Query: 260 LIHAVRGYWL-----------------TNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWP 302
+H + +++ ++ PS+G+L + CD++ +Y F P
Sbjct: 286 KLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLP 345
Query: 303 FPKDLNGKAVKYHY 316
+ + V Y+Y
Sbjct: 346 SKRKTD---VCYYY 356
>gi|5174697 alpha2,3-sialyltransferase VI [Homo sapiens]
Length = 331
Score = 59.3 bits (142), Expect = 5e-09
Identities = 56/220 (25%), Positives = 90/220 (40%), Gaps = 46/220 (20%)
Query: 140 KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAF 199
K C VVGN G+L + G++IDS++ +IR N PV+ +VG ++ F P V
Sbjct: 116 KKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESV---- 171
Query: 200 GGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAY--PS 257
F + ++ + + AF + W+ L++ +K+ + P+
Sbjct: 172 -----------FSDPIHNDPNTTVILTAFK----PHDLRWLLELLMGDKINTNGFWKKPA 216
Query: 258 LRLIH-------------AVRGYWL--------TNKVPIKRPSTGLLMYTLATRFCDEIH 296
L LI+ Y L N+ P K P+TG++ TLA C E+H
Sbjct: 217 LNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKP-KHPTTGIIAITLAFYICHEVH 275
Query: 297 LYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLE 336
L GF DL HYY + + + H + E
Sbjct: 276 LAGFKYNFSDLKS---PLHYYGNATMSLMNKNAYHNVTAE 312
>gi|28373086 sialyltransferase 6 isoform i [Homo sapiens]
Length = 413
Score = 58.2 bits (139), Expect = 1e-08
Identities = 56/230 (24%), Positives = 94/230 (40%), Gaps = 24/230 (10%)
Query: 125 HSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
+ L P + ++ RR C +VGN G+L + G ID ++ V+R N APV F DVG+K
Sbjct: 184 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 240
Query: 185 SDF-ITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFM----VKGGEKHVEW 239
+ IT +QR + +R+ W+ + V + +
Sbjct: 241 TTLRITYPEGAMQRP-----EQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKS 295
Query: 240 VNALILKNKLKVRTAYP------SLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCD 293
V + K ++R P + LI L + I P+ G + T+A CD
Sbjct: 296 VATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNI--PTLGSVAVTMALHGCD 353
Query: 294 EIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVL 343
E+ + G F D++ HYY+ ++ + H + E + L L
Sbjct: 354 EVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 400
>gi|28373082 sialyltransferase 6 isoform g [Homo sapiens]
Length = 359
Score = 58.2 bits (139), Expect = 1e-08
Identities = 56/230 (24%), Positives = 94/230 (40%), Gaps = 24/230 (10%)
Query: 125 HSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
+ L P + ++ RR C +VGN G+L + G ID ++ V+R N APV F DVG+K
Sbjct: 130 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 186
Query: 185 SDF-ITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFM----VKGGEKHVEW 239
+ IT +QR + +R+ W+ + V + +
Sbjct: 187 TTLRITYPEGAMQRP-----EQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKS 241
Query: 240 VNALILKNKLKVRTAYP------SLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCD 293
V + K ++R P + LI L + I P+ G + T+A CD
Sbjct: 242 VATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNI--PTLGSVAVTMALHGCD 299
Query: 294 EIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVL 343
E+ + G F D++ HYY+ ++ + H + E + L L
Sbjct: 300 EVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 346
>gi|28373078 sialyltransferase 6 isoform f [Homo sapiens]
Length = 429
Score = 58.2 bits (139), Expect = 1e-08
Identities = 56/230 (24%), Positives = 94/230 (40%), Gaps = 24/230 (10%)
Query: 125 HSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
+ L P + ++ RR C +VGN G+L + G ID ++ V+R N APV F DVG+K
Sbjct: 200 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 256
Query: 185 SDF-ITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFM----VKGGEKHVEW 239
+ IT +QR + +R+ W+ + V + +
Sbjct: 257 TTLRITYPEGAMQRP-----EQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKS 311
Query: 240 VNALILKNKLKVRTAYP------SLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCD 293
V + K ++R P + LI L + I P+ G + T+A CD
Sbjct: 312 VATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNI--PTLGSVAVTMALHGCD 369
Query: 294 EIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVL 343
E+ + G F D++ HYY+ ++ + H + E + L L
Sbjct: 370 EVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 416
>gi|28373070 sialyltransferase 6 isoform b [Homo sapiens]
Length = 390
Score = 58.2 bits (139), Expect = 1e-08
Identities = 56/230 (24%), Positives = 94/230 (40%), Gaps = 24/230 (10%)
Query: 125 HSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
+ L P + ++ RR C +VGN G+L + G ID ++ V+R N APV F DVG+K
Sbjct: 161 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 217
Query: 185 SDF-ITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFM----VKGGEKHVEW 239
+ IT +QR + +R+ W+ + V + +
Sbjct: 218 TTLRITYPEGAMQRP-----EQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKS 272
Query: 240 VNALILKNKLKVRTAYP------SLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCD 293
V + K ++R P + LI L + I P+ G + T+A CD
Sbjct: 273 VATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNI--PTLGSVAVTMALHGCD 330
Query: 294 EIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVL 343
E+ + G F D++ HYY+ ++ + H + E + L L
Sbjct: 331 EVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 377
>gi|28373068 sialyltransferase 6 isoform a [Homo sapiens]
Length = 444
Score = 58.2 bits (139), Expect = 1e-08
Identities = 56/230 (24%), Positives = 94/230 (40%), Gaps = 24/230 (10%)
Query: 125 HSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
+ L P + ++ RR C +VGN G+L + G ID ++ V+R N APV F DVG+K
Sbjct: 215 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 271
Query: 185 SDF-ITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFM----VKGGEKHVEW 239
+ IT +QR + +R+ W+ + V + +
Sbjct: 272 TTLRITYPEGAMQRP-----EQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKS 326
Query: 240 VNALILKNKLKVRTAYP------SLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCD 293
V + K ++R P + LI L + I P+ G + T+A CD
Sbjct: 327 VATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNI--PTLGSVAVTMALHGCD 384
Query: 294 EIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVL 343
E+ + G F D++ HYY+ ++ + H + E + L L
Sbjct: 385 EVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 431
>gi|5454060 sialyltransferase 6 isoform j [Homo sapiens]
Length = 375
Score = 58.2 bits (139), Expect = 1e-08
Identities = 56/230 (24%), Positives = 94/230 (40%), Gaps = 24/230 (10%)
Query: 125 HSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
+ L P + ++ RR C +VGN G+L + G ID ++ V+R N APV F DVG+K
Sbjct: 146 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 202
Query: 185 SDF-ITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFM----VKGGEKHVEW 239
+ IT +QR + +R+ W+ + V + +
Sbjct: 203 TTLRITYPEGAMQRP-----EQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKS 257
Query: 240 VNALILKNKLKVRTAYP------SLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCD 293
V + K ++R P + LI L + I P+ G + T+A CD
Sbjct: 258 VATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNI--PTLGSVAVTMALHGCD 315
Query: 294 EIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVL 343
E+ + G F D++ HYY+ ++ + H + E + L L
Sbjct: 316 EVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 362
>gi|215272345 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
isoform a [Homo sapiens]
Length = 529
Score = 56.2 bits (134), Expect = 4e-08
Identities = 53/213 (24%), Positives = 90/213 (42%), Gaps = 38/213 (17%)
Query: 127 LLPEV--SPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
L+P V S + R ++CAVV ++G +L+S G+EIDSH+ V+R N AP + DVG K
Sbjct: 279 LVPAVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNK 338
Query: 185 SDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALI 244
+ +N ++ F + S + + V W PA + +N
Sbjct: 339 TTIRIINSQILTNPSHHFIDSSLYKDVI--------LVAWDPA-------PYSANLNLWY 383
Query: 245 LKNKLKVRTAYPSLRLIHAVRGYWLTN-----------------KVPIKRPSTGLLMYTL 287
K + T Y R + + +++ + K+ PS+G + +
Sbjct: 384 KKPDYNLFTPYIQHRQRNPNQPFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILI 443
Query: 288 ATRFCDEIHLYGFWPFPKDLNGKAVKYH--YYD 318
C E+H+Y + P + + YH YYD
Sbjct: 444 MMSMCREVHVYEYIPSVRQT--ELCHYHELYYD 474
>gi|26190610 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
isoform a [Homo sapiens]
Length = 529
Score = 56.2 bits (134), Expect = 4e-08
Identities = 53/213 (24%), Positives = 90/213 (42%), Gaps = 38/213 (17%)
Query: 127 LLPEV--SPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
L+P V S + R ++CAVV ++G +L+S G+EIDSH+ V+R N AP + DVG K
Sbjct: 279 LVPAVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNK 338
Query: 185 SDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALI 244
+ +N ++ F + S + + V W PA + +N
Sbjct: 339 TTIRIINSQILTNPSHHFIDSSLYKDVI--------LVAWDPA-------PYSANLNLWY 383
Query: 245 LKNKLKVRTAYPSLRLIHAVRGYWLTN-----------------KVPIKRPSTGLLMYTL 287
K + T Y R + + +++ + K+ PS+G + +
Sbjct: 384 KKPDYNLFTPYIQHRQRNPNQPFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILI 443
Query: 288 ATRFCDEIHLYGFWPFPKDLNGKAVKYH--YYD 318
C E+H+Y + P + + YH YYD
Sbjct: 444 MMSMCREVHVYEYIPSVRQT--ELCHYHELYYD 474
>gi|215272347 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
isoform b [Homo sapiens]
Length = 466
Score = 52.8 bits (125), Expect = 5e-07
Identities = 28/71 (39%), Positives = 44/71 (61%), Gaps = 2/71 (2%)
Query: 127 LLPEV--SPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
L+P V S + R ++CAVV ++G +L+S G+EIDSH+ V+R N AP + DVG K
Sbjct: 279 LVPAVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNK 338
Query: 185 SDFITMNPSVV 195
+ +N ++
Sbjct: 339 TTIRIINSQIL 349
>gi|28373074 sialyltransferase 6 isoform d [Homo sapiens]
Length = 277
Score = 51.2 bits (121), Expect = 1e-06
Identities = 28/74 (37%), Positives = 41/74 (55%), Gaps = 4/74 (5%)
Query: 125 HSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTK 184
+ L P + ++ RR C +VGN G+L + G ID ++ V+R N APV F DVG+K
Sbjct: 146 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 202
Query: 185 SDF-ITMNPSVVQR 197
+ IT +QR
Sbjct: 203 TTLRITYPEGAMQR 216
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,719,691
Number of Sequences: 37866
Number of extensions: 525370
Number of successful extensions: 931
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 854
Number of HSP's gapped (non-prelim): 55
length of query: 359
length of database: 18,247,518
effective HSP length: 103
effective length of query: 256
effective length of database: 14,347,320
effective search space: 3672913920
effective search space used: 3672913920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.