Search of human proteins with 4504661

Search of human proteins with 4504661

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504661 interleukin 1 receptor accessory protein isoform 1
[Homo sapiens]
         (570 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504661 interleukin 1 receptor accessory protein isoform 1 [H...  1163   0.0  
gi|19882209 interleukin 1 receptor accessory protein isoform 2 [...   733   0.0  
gi|11225607 interleukin 1 receptor accessory protein-like 2 [Hom...   327   2e-89
gi|7657232 interleukin 1 receptor accessory protein-like 1 precu...   303   3e-82
gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]         194   1e-49
gi|4504657 interleukin 18 receptor accessory protein precursor [...   181   1e-45
gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [H...   170   4e-42
gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens]    156   4e-38
gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens]    153   5e-37
gi|27894334 interleukin 1 receptor, type II precursor [Homo sapi...    92   2e-18
gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens]    92   2e-18
gi|205277451 single Ig IL-1R-related molecule [Homo sapiens]           85   2e-16
gi|205277449 single Ig IL-1R-related molecule [Homo sapiens]           85   2e-16
gi|205277445 single Ig IL-1R-related molecule [Homo sapiens]           85   2e-16
gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [H...    82   2e-15
gi|20143971 toll-like receptor 6 [Homo sapiens]                        69   9e-12
gi|41350337 toll-like receptor 1 [Homo sapiens]                        63   8e-10
gi|19924149 toll-like receptor 4 precursor [Homo sapiens]              53   9e-07
gi|62865621 toll-like receptor 10 precursor [Homo sapiens]             52   1e-06
gi|62865618 toll-like receptor 10 precursor [Homo sapiens]             52   1e-06
gi|197276654 myeloid differentiation primary response gene 88 [H...    50   4e-06
gi|7706093 toll-like receptor 7 [Homo sapiens]                         50   6e-06
gi|19718734 toll-like receptor 2 [Homo sapiens]                        48   2e-05
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]     45   2e-04
gi|118572606 hemicentin 1 [Homo sapiens]                               44   3e-04
gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]      43   7e-04
gi|110349719 titin isoform N2-A [Homo sapiens]                         43   9e-04
gi|20302168 toll-like receptor 8 [Homo sapiens]                        42   0.001
gi|28373126 contactin 4 isoform c precursor [Homo sapiens]             40   0.008
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]             40   0.008

>gi|4504661 interleukin 1 receptor accessory protein isoform 1 [Homo
           sapiens]
          Length = 570

 Score = 1163 bits (3009), Expect = 0.0
 Identities = 570/570 (100%), Positives = 570/570 (100%)

Query: 1   MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 60
           MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST
Sbjct: 1   MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 60

Query: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120
           AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT
Sbjct: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120

Query: 121 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 180
           YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG
Sbjct: 121 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 180

Query: 181 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 240
           CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA
Sbjct: 181 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 240

Query: 241 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 300
           VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE
Sbjct: 241 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 300

Query: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL 360
           SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL
Sbjct: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL 360

Query: 361 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF 420
           ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF
Sbjct: 361 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF 420

Query: 421 VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL 480
           VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL
Sbjct: 421 VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL 480

Query: 481 LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK 540
           LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK
Sbjct: 481 LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK 540

Query: 541 QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV 570
           QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV
Sbjct: 541 QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV 570


>gi|19882209 interleukin 1 receptor accessory protein isoform 2
           [Homo sapiens]
          Length = 356

 Score =  733 bits (1892), Expect = 0.0
 Identities = 350/350 (100%), Positives = 350/350 (100%)

Query: 1   MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 60
           MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST
Sbjct: 1   MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 60

Query: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120
           AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT
Sbjct: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120

Query: 121 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 180
           YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG
Sbjct: 121 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 180

Query: 181 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 240
           CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA
Sbjct: 181 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 240

Query: 241 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 300
           VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE
Sbjct: 241 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 300

Query: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK 350
           SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK
Sbjct: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK 350


>gi|11225607 interleukin 1 receptor accessory protein-like 2 [Homo
           sapiens]
          Length = 686

 Score =  327 bits (838), Expect = 2e-89
 Identities = 209/587 (35%), Positives = 311/587 (52%), Gaps = 41/587 (6%)

Query: 1   MTLLWC-VVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYS 59
           + L+ C VVS     + + ++ + C DW +D ++       EP R+KC LF  +++ NYS
Sbjct: 7   LALVVCSVVSTNLKMVSKRNSVDGCIDWSVD-LKTYMALAGEPVRVKCALFYSYIRTNYS 65

Query: 60  TAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNT 119
           TA S GL L+WY  +   DLEEPI F   E R+SKE+D +WF      D+G YTC+LRN+
Sbjct: 66  TAQSTGLRLMWY--KNKGDLEEPIIFS--EVRMSKEEDSIWFHSAEAQDSGFYTCVLRNS 121

Query: 120 TYCSKVAFPLEVVQKDS--CFNSPMKLPVHKLYIEYGI----QRITCPNVDGYFPSSVKP 173
           TYC KV+  L V + +S  C+NS ++      Y+E       + I+CP++D +  S  +P
Sbjct: 122 TYCMKVSMSLTVAENESGLCYNSRIR------YLEKSEVTKRKEISCPDMDDFKKSDQEP 175

Query: 174 TITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKV 233
            + WY  C      + +I +G  L        + GNYTC + Y   G+    T  L V  
Sbjct: 176 DVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKY--EGKLVRRTTELKVTA 233

Query: 234 VGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDIT 293
           + + K    P+    N   V + + G+ L IPC  +F F  +S   ++W    K  +++ 
Sbjct: 234 LLTDKPP-KPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELA 292

Query: 294 IDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPA 353
             +   E         E   ++  I     E    +Y CH  +  G   K A V  +   
Sbjct: 293 GHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGR--KHASVLLRKKD 350

Query: 354 PRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYAR 413
             Y +ELA G GA  LL+V+L+V+Y  Y +E++LFYR HFG DET  D KEYD Y+SY +
Sbjct: 351 LIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTK 410

Query: 414 ---------NAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRL 464
                    N EEE+F L  L  VLE  +GYKL I +RD +P G   ++   ++++SRRL
Sbjct: 411 VDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRL 470

Query: 465 LVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKE----TKVKELKRAKTV 520
           ++VL+P+Y+L+   ++ EL++ L NM   G I VIL++   +K      +V+ LKR+  +
Sbjct: 471 IIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKL 530

Query: 521 LTVIKWKGEKSKYPQGRFWKQLQVAMPVKKS---PRRS--SSDEQGL 562
           L++IKWKG KS     +FWK L   MP+KK    PR     S EQGL
Sbjct: 531 LSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGL 577


>gi|7657232 interleukin 1 receptor accessory protein-like 1
           precursor [Homo sapiens]
          Length = 696

 Score =  303 bits (776), Expect = 3e-82
 Identities = 192/568 (33%), Positives = 294/568 (51%), Gaps = 30/568 (5%)

Query: 1   MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 60
           + LL+   +     + +  +++ C DW +D +++ QV   EP RIKC LF  +++ NYS 
Sbjct: 8   LILLYATFTQSLKVVTKRGSADGCTDWSID-IKKYQVLVGEPVRIKCALFYGYIRTNYSL 66

Query: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120
           A SAGL+L+WY +    D EEPI F    +R+SKE+D +WFRPTLL D+G Y C++RN+T
Sbjct: 67  AQSAGLSLMWYKSSGPGDFEEPIAF--DGSRMSKEEDSIWFRPTLLQDSGLYACVIRNST 124

Query: 121 YCSKVAFPLEVVQKDS--CFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWY 178
           YC KV+  L V + D+  C+NS MK    K  +    + I+C +++ +   + +P I WY
Sbjct: 125 YCMKVSISLTVGENDTGLCYNSKMKY-FEKAELSKS-KEISCRDIEDFLLPTREPEILWY 182

Query: 179 MGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPK 238
             C       +++ +   L        + GNYTC + Y   G     T  LTV    +P 
Sbjct: 183 KECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKY--GGFVVRRTTELTVT---APL 237

Query: 239 NAVPPVIHSPNDH--VVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDV 296
              PP +  P +    + E + G+   + C  +F +  D    ++W    K  +D+  + 
Sbjct: 238 TDKPPKLLYPMESKLTIQETQLGDSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENR 297

Query: 297 TINESISHSRTE-DETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPR 355
                I   +    E    I  I     E    +Y C+  +  G   + A V        
Sbjct: 298 VWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGR--RHASVLLHKRELM 355

Query: 356 YTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYAR-- 413
           YTVELA G GA +LL+V L+ +Y  Y +E++LFYR HFG +E   D K+YD Y+SY +  
Sbjct: 356 YTVELAGGLGAILLLLVCLVTIYKCYKIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVD 415

Query: 414 -------NAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLV 466
                    EEE F L  L  +LE  +GYKL I DRD +P G   ++    + +S+RL++
Sbjct: 416 PDQWNQETGEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLII 475

Query: 467 VLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVK----ETKVKELKRAKTVLT 522
           V++PNYV++   ++ EL+  L NM   G I VIL++   ++      +V+ LK    +LT
Sbjct: 476 VMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEVEALKHTIKLLT 535

Query: 523 VIKWKGEKSKYPQGRFWKQLQVAMPVKK 550
           VIKW G K      +FWK+LQ  MP K+
Sbjct: 536 VIKWHGPKCNKLNSKFWKRLQYEMPFKR 563


>gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]
          Length = 541

 Score =  194 bits (494), Expect = 1e-49
 Identities = 166/530 (31%), Positives = 250/530 (47%), Gaps = 49/530 (9%)

Query: 35  IQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTL-IWYWTRQDRDLEEPINFRLPENRIS 93
           I V E EP  +K          + S AH    T   WY +   ++  E +N R   +RI+
Sbjct: 28  ITVVEGEPFYLK--------HCSCSLAHEIETTTKSWYKSSGSQEHVE-LNPR-SSSRIA 77

Query: 94  KEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQ--KDSCFNSPMKLPVHKLYI 151
               VL F P  LNDTG+Y   ++N T   K    L V++  K SCF    +    K+  
Sbjct: 78  LHDCVLEFWPVELNDTGSYFFQMKNYTQKWK----LNVIRRNKHSCFTE--RQVTSKIVE 131

Query: 152 EYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPE-GMNLSFLIALISNNGNY 210
                +ITC N   Y+ + V  T + Y  C K+   NN  P    N  F      + G Y
Sbjct: 132 VKKFFQITCEN--SYYQTLVNST-SLYKNCKKLLLENNKNPTIKKNAEF-----EDQGYY 183

Query: 211 TCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYF 270
           +CV     NG+ F++T+T  + +V    N VP ++    +HV  E   G+ + + C    
Sbjct: 184 SCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVEL--GKNVRLNC---- 237

Query: 271 SFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSY 330
           S L++  + ++W    +   D  I       I     +    +++L I+ +   +L   Y
Sbjct: 238 SALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHA-SKVLRIENIGESNLNVLY 296

Query: 331 VCHARSAKGEVAKAAKVKQK-----VPAPRYTVELACGFGATVLLVVILIVVYHVYWLEM 385
            C   S  G   K+  + +K     +P   +T  +       ++ VV L+ V  +Y +++
Sbjct: 297 NCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAV-LILVAVVCLVTVCVIYRVDL 355

Query: 386 VLFYRAHFGTDETILDGKEYDIYVSYAR-----NAEEEEFVLLTLRGVLENEFGYKLCIF 440
           VLFYR     DET+ DGK YD +VSY +     N EE  F +  L  VLE  FGYKLCIF
Sbjct: 356 VLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIF 415

Query: 441 DRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVIL 500
           +RD +PGG V DE  S I+KSRRL++VLS +Y+    +   EL++GL        I +IL
Sbjct: 416 ERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYM--SNEVRYELESGLHEALVERKIKIIL 473

Query: 501 VQYKAVKE-TKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVK 549
           +++  V + T + +  +      V+KWK +KS     RFWK L   MP K
Sbjct: 474 IEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAK 523


>gi|4504657 interleukin 18 receptor accessory protein precursor
           [Homo sapiens]
          Length = 599

 Score =  181 bits (460), Expect = 1e-45
 Identities = 143/523 (27%), Positives = 244/523 (46%), Gaps = 57/523 (10%)

Query: 70  WYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLR------NTTYCS 123
           WY    + D  E I    P   I ++K  L F    +N++G+Y C  +      +   C 
Sbjct: 84  WYQQPSNGDPLEDIRKSYPH--IIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCV 141

Query: 124 KVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQ-RITCPNVDGYFPSSVKPTITWYMG-- 180
           K+   ++     SC  S      HK  +  G    I+CP++     +   P +TWY    
Sbjct: 142 KMILEVKPQTNASCEYSAS----HKQDLLLGSTGSISCPSLSCQSDAQ-SPAVTWYKNGK 196

Query: 181 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 240
              ++  N ++ + +          + G Y C  T  +   ++ +   + V+ +      
Sbjct: 197 LLSVERSNRIVVDEV-------YDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKL 249

Query: 241 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 300
            P ++    D +  E E G+ L I C   F F       + W I   K  D+  +V++ E
Sbjct: 250 KPDILDPVEDTL--EVELGKPLTISCKARFGFERVFNPVIKWYI---KDSDLEWEVSVPE 304

Query: 301 SISHSRT-EDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVE 359
           + S   T +DE   + + ++KVT  DL+R +VC  +++ G   ++ ++K+K    R  V 
Sbjct: 305 AKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEK----RGVVL 360

Query: 360 LACGFGATVLLVVILIVVYHVY--WLEMVLFYRAHFGTDETILDGKEYDIYVSYAR---- 413
           L    G    LV +L     +Y  W+E+VL YR +   D+T+ D K++D +VSYA+    
Sbjct: 361 LYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSF 420

Query: 414 ------NAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVV 467
                 +  EE   L     VLEN++GY LC+ +RD  PGG+  ++ +S I++SRR + +
Sbjct: 421 PSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFI 480

Query: 468 LSPNYVLQGTQALLELKAGLENMASRGNINVILVQ--YKAVKETKVKELKRAKTVLTVIK 525
           LSPNYV     ++ EL+A +        + +IL++  Y    E+    +K+A  VL  + 
Sbjct: 481 LSPNYV--NGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVT 538

Query: 526 WKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLK 568
           W+G KS  P  RFW +++  MPVK S        QG +++ L+
Sbjct: 539 WRGLKSVPPNSRFWAKMRYHMPVKNS--------QGFTWNQLR 573


>gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [Homo
           sapiens]
          Length = 556

 Score =  170 bits (430), Expect = 4e-42
 Identities = 139/519 (26%), Positives = 235/519 (45%), Gaps = 44/519 (8%)

Query: 67  TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 126
           T+ WY+++ ++ +  P   R   NR+     +L F P  + D+G YTC++R+ T+     
Sbjct: 45  TVDWYYSQTNKSI--PTQER---NRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGY 99

Query: 127 FPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQN 186
             + + +K S  N P  L    +       +I CP +D Y   +    + W+  C  +Q 
Sbjct: 100 ANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLY---NWTAPLEWFKNCQALQG 156

Query: 187 FNNVIPEGMNLSFLI---ALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPP 243
                    + SFL+    +  + G+YTC   + ENG  + +T T +  V      ++ P
Sbjct: 157 SRY----RAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFP 212

Query: 244 VIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDD-----ITIDVTI 298
           VI +P  + + E E G+   + C+  F         V W ++G K  D     I  +   
Sbjct: 213 VIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQ 272

Query: 299 NESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTV 358
           N+S S+          +L I  V  EDL   Y C A +  G      ++ +K P   +++
Sbjct: 273 NQSFSNGLA---CLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPIDHHSI 329

Query: 359 ELACGFGATVLLVV-ILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEE 417
                  +  L+++ +L+++  ++W+E  L +R      +T  DGK YD YV Y RN + 
Sbjct: 330 YCIIAVCSVFLMLINVLVIILKMFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKS 389

Query: 418 --------EEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLS 469
                   E FV   L  VLEN+ GY LCI+ RD LPG  V     + I+KSRR + +L+
Sbjct: 390 STDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILT 449

Query: 470 PNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKE-------LKRAKTVLT 522
           P  +    +   E +  L     + +  VIL++ +A+ E  + +       L+    V  
Sbjct: 450 PQ-ITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQG 508

Query: 523 VIKWKGE---KSKYPQGRFWKQLQVAMPV-KKSPRRSSS 557
            IKW+ +     +    +FWK ++  MPV  K PR++SS
Sbjct: 509 TIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIPRKASS 547


>gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens]
          Length = 575

 Score =  156 bits (395), Expect = 4e-38
 Identities = 136/513 (26%), Positives = 246/513 (47%), Gaps = 46/513 (8%)

Query: 63  SAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYC 122
           S  +++ WY        + P++ ++ ++RI +++  + F P    D+G Y C+++    C
Sbjct: 49  SGEVSVTWY----KNSSKIPVS-KIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSC 103

Query: 123 SKVAFPLEVVQKDSCFNSPMKLP----VHKLYIEYGIQ-RITCPNVDGYFPSS-VKPTIT 176
            ++   L V +K  C  S   LP     +K  +  G    +TC     +FP S V   I 
Sbjct: 104 HRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHL---HFPKSCVLGPIK 160

Query: 177 WYMGCYKIQNFNNVIPEGMNLSFLIALIS--NNGNYTCVVTYPENGRTFHLTRTLTVKVV 234
           WY  C +I+     + E      L++ +S  + GNY C      +G+ + +   +TV + 
Sbjct: 161 WYKDCNEIKGERFTVLE---TRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSIT 217

Query: 235 --GSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDI 292
                  +VP +I+ P +H + E + G  L++ C V  +   D+ N   W ++    DD 
Sbjct: 218 ERAGYGGSVPKIIY-PKNHSI-EVQLGTTLIVDCNV--TDTKDNTNLRCWRVNNTLVDDY 273

Query: 293 TIDVT-INESISH--SRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQ 349
             +   I E +    S  E    T  ++  +V  ED    ++CHA          A +  
Sbjct: 274 YDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAG------VSTAYIIL 327

Query: 350 KVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYV 409
           ++PAP +   L  G  A V + V ++ +Y+++ +++VL+YR+ F + ETI+DGK YD YV
Sbjct: 328 QLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYV 387

Query: 410 SYARNAEEEE------FVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRR 463
            Y +  +E +       VL  L  VLE + GYKL IF RD  PG  V +     ++  RR
Sbjct: 388 LYPKPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRR 447

Query: 464 LLVVLSPNYVLQG-TQALLELKAGLENMASRGNINVILVQYKAVKETKV--KELKRAKTV 520
           L+V++ P  +  G  + L E +  + +   +  + VIL++ + +++  V  + ++  K  
Sbjct: 448 LIVIVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQK 507

Query: 521 LTVIKWKG---EKSKYPQGRFWKQLQVAMPVKK 550
              I+W G   E+S+  + +FWK ++  MP ++
Sbjct: 508 HGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRR 540


>gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens]
          Length = 569

 Score =  153 bits (386), Expect = 5e-37
 Identities = 129/524 (24%), Positives = 241/524 (45%), Gaps = 51/524 (9%)

Query: 67  TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 126
           T+ WY      D + P++     +RI + K+ LWF P  + D+G+Y C++RN++YC ++ 
Sbjct: 54  TITWY----KDDSKTPVSTE-QASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIK 108

Query: 127 FPLEVVQKDS--CFNS----PMKLPVHKLYIEYGIQRITCPNVDGY-FPSSVKPTITWYM 179
              + V+ +   C+N+      KLPV       G   + CP ++ +   ++  P + WY 
Sbjct: 109 ISAKFVENEPNLCYNAQAIFKQKLPV------AGDGGLVCPYMEFFKNENNELPKLQWYK 162

Query: 180 GCYKIQNFNNVIPEGMNLSFLIALIS--NNGNYTCVVTYPENGRTFHLTRTLTVKVVGSP 237
            C K    +N+   G+    ++  ++  + GNYTC  +Y   G+ + +TR +    +   
Sbjct: 163 DC-KPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEEN 221

Query: 238 KNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGK--KPDDITID 295
           K   P ++   N+    E + G ++ + C V         +  +W  +G     DD  + 
Sbjct: 222 KPTRPVIVSPANE--TMEVDLGSQIQLICNVTGQL----SDIAYWKWNGSVIDEDDPVLG 275

Query: 296 VTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPR 355
                  + +     T   +L+I ++ S   K  + C A++  G    AA ++   P   
Sbjct: 276 EDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG--IDAAYIQLIYPVTN 333

Query: 356 YTVELACGFGATVLLVVILIVVYHVYWLEMVLFYR--AHFGTDETILDGKEYDIYVSYAR 413
           +   +        +++V  + +Y ++ +++VL+YR   +        DGK YD Y+ Y +
Sbjct: 334 FQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPK 393

Query: 414 NAEE------EEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVV 467
              E      + FV   L  VLE + GYKL I+ RD   G  + +     ++KSRRL+++
Sbjct: 394 TVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIII 453

Query: 468 L---SPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVK--ETKVKELKRAKTVLT 522
           L   +  +   G  +  E +  + N   +  I V+L++ + ++  E   + +K  K    
Sbjct: 454 LVRETSGFSWLGGSS--EEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHG 511

Query: 523 VIKWKGEKSKYPQG---RFWKQLQVAMPVKKSPRRSSSDEQGLS 563
            I+W G+ ++ PQ    RFWK ++  MPV++  R  SS  Q LS
Sbjct: 512 AIRWSGDFTQGPQSAKTRFWKNVRYHMPVQR--RSPSSKHQLLS 553


>gi|27894334 interleukin 1 receptor, type II precursor [Homo
           sapiens]
          Length = 398

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 73/318 (22%), Positives = 127/318 (39%), Gaps = 20/318 (6%)

Query: 20  ASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDL 79
           A+  C   G    R+ ++ E EP  ++CP   ++L  + S      + L W+     R +
Sbjct: 24  AARSCRFRGRHYKREFRL-EGEPVALRCPQVPYWLWASVSPR----INLTWHKNDSARTV 78

Query: 80  EEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFN 139
                    E R+  +   LW  P L  D+G Y C  RN +YC K++  L V +    F 
Sbjct: 79  PGE-----EETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFL 133

Query: 140 SPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSF 199
             +  P        G+  + CP++  +        I WY     +   N         + 
Sbjct: 134 PFISYPQILTLSTSGV--LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTH 191

Query: 200 LI---ALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEK 256
           L+     + + G Y CV+T+   G+ +++TR++ +++    +  + PVI SP   +    
Sbjct: 192 LLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVIISPLKTI--SA 248

Query: 257 EPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTE-DETRTQI 315
             G  L IPC V+          +WWT +    +       + E      +E +E   ++
Sbjct: 249 SLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEV 308

Query: 316 -LSIKKVTSEDLKRSYVC 332
            L    VT EDL   + C
Sbjct: 309 PLIFDPVTREDLHMDFKC 326


>gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens]
          Length = 398

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 73/318 (22%), Positives = 127/318 (39%), Gaps = 20/318 (6%)

Query: 20  ASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDL 79
           A+  C   G    R+ ++ E EP  ++CP   ++L  + S      + L W+     R +
Sbjct: 24  AARSCRFRGRHYKREFRL-EGEPVALRCPQVPYWLWASVSPR----INLTWHKNDSARTV 78

Query: 80  EEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFN 139
                    E R+  +   LW  P L  D+G Y C  RN +YC K++  L V +    F 
Sbjct: 79  PGE-----EETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFL 133

Query: 140 SPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSF 199
             +  P        G+  + CP++  +        I WY     +   N         + 
Sbjct: 134 PFISYPQILTLSTSGV--LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTH 191

Query: 200 LI---ALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEK 256
           L+     + + G Y CV+T+   G+ +++TR++ +++    +  + PVI SP   +    
Sbjct: 192 LLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVIISPLKTI--SA 248

Query: 257 EPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTE-DETRTQI 315
             G  L IPC V+          +WWT +    +       + E      +E +E   ++
Sbjct: 249 SLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEV 308

Query: 316 -LSIKKVTSEDLKRSYVC 332
            L    VT EDL   + C
Sbjct: 309 PLIFDPVTREDLHMDFKC 326


>gi|205277451 single Ig IL-1R-related molecule [Homo sapiens]
          Length = 410

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 87/323 (26%), Positives = 150/323 (46%), Gaps = 15/323 (4%)

Query: 243 PVIHSPNDHVVYEKEPGEELLIPCTVYF-SFLMDSRNEVWWTIDGKKPDDITIDVTINE- 300
           P   SP++  V     G  + + CT +  S    S   V W  DG  P  I    +++E 
Sbjct: 9   PDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGL-PLGIGGHYSLHEY 67

Query: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL 360
           S   +   +   + +L +  VTS ++  ++ C  ++       +  +++  P       L
Sbjct: 68  SWVKANLSEVLVSSVLGVN-VTSTEVYGAFTCSIQNIS---FSSFTLQRAGPTSHVAAVL 123

Query: 361 ACGFGATVLLVVILIVVYHVYW-LEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEE 419
           A      VLL ++L  + +V   L ++L+Y+  +G  E I DGK YD YVSY+   E+ +
Sbjct: 124 A---SLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVE-INDGKLYDAYVSYSDCPEDRK 179

Query: 420 FVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQG--T 477
           FV   L+  LE   GYKL + DRD LP    + + L  + + RRL+VVLS  ++ +   +
Sbjct: 180 FVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCS 239

Query: 478 QALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGR 537
            +  E    L  +  R        Q +      ++ L++ + ++T++ W+   S  P   
Sbjct: 240 HSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWR-PGSVTPSSD 298

Query: 538 FWKQLQVAMPVKKSPRRSSSDEQ 560
           FWK++Q+A+P K   R    D Q
Sbjct: 299 FWKEVQLALPRKVQYRPVEGDPQ 321


>gi|205277449 single Ig IL-1R-related molecule [Homo sapiens]
          Length = 410

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 87/323 (26%), Positives = 150/323 (46%), Gaps = 15/323 (4%)

Query: 243 PVIHSPNDHVVYEKEPGEELLIPCTVYF-SFLMDSRNEVWWTIDGKKPDDITIDVTINE- 300
           P   SP++  V     G  + + CT +  S    S   V W  DG  P  I    +++E 
Sbjct: 9   PDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGL-PLGIGGHYSLHEY 67

Query: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL 360
           S   +   +   + +L +  VTS ++  ++ C  ++       +  +++  P       L
Sbjct: 68  SWVKANLSEVLVSSVLGVN-VTSTEVYGAFTCSIQNIS---FSSFTLQRAGPTSHVAAVL 123

Query: 361 ACGFGATVLLVVILIVVYHVYW-LEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEE 419
           A      VLL ++L  + +V   L ++L+Y+  +G  E I DGK YD YVSY+   E+ +
Sbjct: 124 A---SLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVE-INDGKLYDAYVSYSDCPEDRK 179

Query: 420 FVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQG--T 477
           FV   L+  LE   GYKL + DRD LP    + + L  + + RRL+VVLS  ++ +   +
Sbjct: 180 FVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCS 239

Query: 478 QALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGR 537
            +  E    L  +  R        Q +      ++ L++ + ++T++ W+   S  P   
Sbjct: 240 HSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWR-PGSVTPSSD 298

Query: 538 FWKQLQVAMPVKKSPRRSSSDEQ 560
           FWK++Q+A+P K   R    D Q
Sbjct: 299 FWKEVQLALPRKVQYRPVEGDPQ 321


>gi|205277445 single Ig IL-1R-related molecule [Homo sapiens]
          Length = 410

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 87/323 (26%), Positives = 150/323 (46%), Gaps = 15/323 (4%)

Query: 243 PVIHSPNDHVVYEKEPGEELLIPCTVYF-SFLMDSRNEVWWTIDGKKPDDITIDVTINE- 300
           P   SP++  V     G  + + CT +  S    S   V W  DG  P  I    +++E 
Sbjct: 9   PDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGL-PLGIGGHYSLHEY 67

Query: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL 360
           S   +   +   + +L +  VTS ++  ++ C  ++       +  +++  P       L
Sbjct: 68  SWVKANLSEVLVSSVLGVN-VTSTEVYGAFTCSIQNIS---FSSFTLQRAGPTSHVAAVL 123

Query: 361 ACGFGATVLLVVILIVVYHVYW-LEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEE 419
           A      VLL ++L  + +V   L ++L+Y+  +G  E I DGK YD YVSY+   E+ +
Sbjct: 124 A---SLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVE-INDGKLYDAYVSYSDCPEDRK 179

Query: 420 FVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQG--T 477
           FV   L+  LE   GYKL + DRD LP    + + L  + + RRL+VVLS  ++ +   +
Sbjct: 180 FVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCS 239

Query: 478 QALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGR 537
            +  E    L  +  R        Q +      ++ L++ + ++T++ W+   S  P   
Sbjct: 240 HSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWR-PGSVTPSSD 298

Query: 538 FWKQLQVAMPVKKSPRRSSSDEQ 560
           FWK++Q+A+P K   R    D Q
Sbjct: 299 FWKEVQLALPRKVQYRPVEGDPQ 321


>gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [Homo
           sapiens]
          Length = 328

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 73/295 (24%), Positives = 126/295 (42%), Gaps = 23/295 (7%)

Query: 67  TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 126
           T+ WY+++ ++ +  P   R   NR+     +L F P  + D+G YTC++R+ T+     
Sbjct: 45  TVDWYYSQTNKSI--PTQER---NRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGY 99

Query: 127 FPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQN 186
             + + +K S  N P  L    +       +I CP +D Y   +    + W+  C  +Q 
Sbjct: 100 ANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLY---NWTAPLEWFKNCQALQG 156

Query: 187 FNNVIPEGMNLSFLI---ALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPP 243
                    + SFL+    +  + G+YTC   + ENG  + +T T +  V      ++ P
Sbjct: 157 SRY----RAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFP 212

Query: 244 VIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDD-----ITIDVTI 298
           VI +P  + + E E G+   + C+  F         V W ++G K  D     I  +   
Sbjct: 213 VIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQ 272

Query: 299 NESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPA 353
           N+S S+          +L I  V  EDL   Y C A +  G      ++ +K P+
Sbjct: 273 NQSFSNGLA---CLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPS 324


>gi|20143971 toll-like receptor 6 [Homo sapiens]
          Length = 796

 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 70/265 (26%), Positives = 124/265 (46%), Gaps = 41/265 (15%)

Query: 310 ETRTQILSIKKVTSEDLKR---SYVC-HARSAKGEVAKAAKVKQKVPAPRYTVELACGF- 364
           E R  + +I +V+SE L+    SY C +  S +G   K   +           EL+C   
Sbjct: 536 ELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMS----------ELSCNIT 585

Query: 365 ------GATVLLVVILIVVYHVY-----WLEMVLFY-----RAHFGTDETILDGKEYDIY 408
                 GAT+L++ + +    +Y     +L MV  +     RA     E +    ++  +
Sbjct: 586 LLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAF 645

Query: 409 VSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVL 468
           +SY+ +  +  +V   L   LE E   ++C+ +R+ +PG  + +  ++ I+KS + + VL
Sbjct: 646 ISYSEH--DSAWVKSELVPYLEKE-DIQICLHERNFVPGKSIVENIINCIEKSYKSIFVL 702

Query: 469 SPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKE----TKVKELKRAKTVLTVI 524
           SPN+V Q      EL     N+   G+ N+IL+  + + +     K  +LK   T  T +
Sbjct: 703 SPNFV-QSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYL 761

Query: 525 KWKGEKSKYPQGRFWKQLQVAMPVK 549
           +W  EKSK  +G FW  ++ A  +K
Sbjct: 762 QWPKEKSK--RGLFWANIRAAFNMK 784


>gi|41350337 toll-like receptor 1 [Homo sapiens]
          Length = 786

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 65/260 (25%), Positives = 121/260 (46%), Gaps = 41/260 (15%)

Query: 315 ILSIKKVTSEDLKR---SYVC-HARSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLL 370
           + +I +V+SE L+    SY C +  S +G + K   +           EL+C     ++ 
Sbjct: 536 VKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMS----------ELSCNITLLIVT 585

Query: 371 VVILIVVYHV------------YWLEMVLFY-----RAHFGTDETILDGKEYDIYVSYAR 413
           +V  ++V  V            ++L MV  +     RA     E +    ++  ++SY+ 
Sbjct: 586 IVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYS- 644

Query: 414 NAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYV 473
              +  +V   L   LE E G ++C+ +R+ +PG  + +  ++ I+KS + + VLSPN+V
Sbjct: 645 -GHDSFWVKNELLPNLEKE-GMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFV 702

Query: 474 LQGTQALLELKAGLENMASRGNINVILVQYKAVKETKV----KELKRAKTVLTVIKWKGE 529
            Q      EL     N+   G+ ++IL+  + + +  +     +LK      T ++W  E
Sbjct: 703 -QSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKE 761

Query: 530 KSKYPQGRFWKQLQVAMPVK 549
           KSK  +G FW  L+ A+ +K
Sbjct: 762 KSK--RGLFWANLRAAINIK 779


>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
          Length = 839

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 55/226 (24%), Positives = 105/226 (46%), Gaps = 24/226 (10%)

Query: 340 EVAKAAKVKQKVPAPRYTVELACGFGATVLLV---------VILIVVYHVYWLEMVLFYR 390
           E  + A    K   P  ++ + C    T++ V         V+ ++VY  Y+  M+L   
Sbjct: 605 ERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGC 664

Query: 391 AHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTL-RGVLENEFGYKLCIFDRDSLPG-G 448
             +G  E I     YD +V Y+  +++E++V   L + + E    ++LC+  RD +PG  
Sbjct: 665 IKYGRGENI-----YDAFVIYS--SQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVA 717

Query: 449 IVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKE 508
           I  +       KSR+++VV+S +++ Q    + E +             +I +  + V++
Sbjct: 718 IAANIIHEGFHKSRKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEK 776

Query: 509 TKVK---ELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKS 551
           T ++   EL R  +  T ++W  E S   +  FW++L+ A+   KS
Sbjct: 777 TLLRQQVELYRLLSRNTYLEW--EDSVLGRHIFWRRLRKALLDGKS 820


>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
          Length = 811

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 49/212 (23%), Positives = 97/212 (45%), Gaps = 27/212 (12%)

Query: 359 ELACGFGATVLLVVILIVVYHV------------YWLEMV-----LFYRAHFGTDETILD 401
           EL+C     ++ +V++++V  +            ++L M+      ++R    T E +  
Sbjct: 571 ELSCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKR 630

Query: 402 GKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKL-CIFDRDSLPGGIVTDETLSFIQK 460
              +  ++SY+ +  +  +V   L   LE E G  L C+++    PG  +++  +SFI+K
Sbjct: 631 NVRFHAFISYSEH--DSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEK 688

Query: 461 SRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVK----ETKVKELKR 516
           S + + VLSPN+V Q      E      N+    + ++IL+  + +      T+  +LK 
Sbjct: 689 SYKSIFVLSPNFV-QNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKA 747

Query: 517 AKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPV 548
                  ++W  ++ K   G FW  L+ A+ V
Sbjct: 748 LLEKKAYLEWPKDRRKC--GLFWANLRAAINV 777


>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
          Length = 811

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 49/212 (23%), Positives = 97/212 (45%), Gaps = 27/212 (12%)

Query: 359 ELACGFGATVLLVVILIVVYHV------------YWLEMV-----LFYRAHFGTDETILD 401
           EL+C     ++ +V++++V  +            ++L M+      ++R    T E +  
Sbjct: 571 ELSCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKR 630

Query: 402 GKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKL-CIFDRDSLPGGIVTDETLSFIQK 460
              +  ++SY+ +  +  +V   L   LE E G  L C+++    PG  +++  +SFI+K
Sbjct: 631 NVRFHAFISYSEH--DSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEK 688

Query: 461 SRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVK----ETKVKELKR 516
           S + + VLSPN+V Q      E      N+    + ++IL+  + +      T+  +LK 
Sbjct: 689 SYKSIFVLSPNFV-QNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKA 747

Query: 517 AKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPV 548
                  ++W  ++ K   G FW  L+ A+ V
Sbjct: 748 LLEKKAYLEWPKDRRKC--GLFWANLRAAINV 777


>gi|197276654 myeloid differentiation primary response gene 88 [Homo
           sapiens]
          Length = 309

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 41/145 (28%), Positives = 69/145 (47%), Gaps = 11/145 (7%)

Query: 403 KEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQK-S 461
           + +D ++ Y  +  + +FV   +R + +  +  KLC+ DRD LPG  V       I+K  
Sbjct: 172 ERFDAFICYCPS--DIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRC 229

Query: 462 RRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVL 521
           RR++VV+S +Y LQ  +   + K  L          +I ++YKA+K    KE       +
Sbjct: 230 RRMVVVVSDDY-LQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMK----KEFPSILRFI 284

Query: 522 TVIKWKGEKSKYPQGRFWKQLQVAM 546
           TV  +    +K     FW +L  A+
Sbjct: 285 TVCDYTNPCTK---SWFWTRLAKAL 306


>gi|7706093 toll-like receptor 7 [Homo sapiens]
          Length = 1049

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 42/187 (22%), Positives = 87/187 (46%), Gaps = 13/187 (6%)

Query: 369  LLVVILIVVYHVYWLEMVLFYRAHF------GTDETILDGKEYDIYVSY-ARNAEEEEFV 421
            L +++++   H+Y+ ++   Y  HF      G    I     YD ++ Y  ++    E+V
Sbjct: 851  LFLMVMMTASHLYFWDVWYIY--HFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWV 908

Query: 422  LLTLRGVLEN--EFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQA 479
            L  L   LE+  E  + LC+ +RD LPG  V +     IQ S++ + V++  Y       
Sbjct: 909  LAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFK 968

Query: 480  LLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFW 539
            +    +    M  + ++ +++   K  +++K  +L++     +V++W      +P   FW
Sbjct: 969  IAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPY--FW 1026

Query: 540  KQLQVAM 546
            + L+ A+
Sbjct: 1027 QCLKNAL 1033


>gi|19718734 toll-like receptor 2 [Homo sapiens]
          Length = 784

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 45/195 (23%), Positives = 88/195 (45%), Gaps = 14/195 (7%)

Query: 360 LACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKE--YDIYVSYA-RNAE 416
           + C     +LL  +L   +H  W   +++              +   YD +VSY+ R+A 
Sbjct: 594 MCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAY 653

Query: 417 EEEFVLLTLRGVLEN-EFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQ 475
             E +++     LEN    +KLC+  RD +PG  + D  +  I+KS + + VLS N+V +
Sbjct: 654 WVENLMVQ---ELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFV-K 709

Query: 476 GTQALLELKAGLENMASRGNINVILVQYKAVKETKVKE----LKRAKTVLTVIKWKGEKS 531
                 EL      +    N   IL+  + +++  + +    L++     T ++W  +++
Sbjct: 710 SEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEA 769

Query: 532 KYPQGRFWKQLQVAM 546
           +  +  FW  L+ A+
Sbjct: 770 Q--REGFWVNLRAAI 782


>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
          Length = 1032

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 40/157 (25%), Positives = 72/157 (45%), Gaps = 9/157 (5%)

Query: 394  GTDETILDGKEYDIYVSYARNAEE-EEFVLLTLRGVLEN---EFGYKLCIFDRDSLPGGI 449
            G DE   D   YD +V + +      ++V   LRG LE     +  +LC+ +RD LPG  
Sbjct: 862  GRDE---DALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKT 918

Query: 450  VTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKET 509
            + +   + +  SR+ L VL+    + G      L A    +  R ++ V+++     + +
Sbjct: 919  LFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRS 978

Query: 510  KVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAM 546
            +   L++     +V+ W  + S   Q  FW QL +A+
Sbjct: 979  RYVRLRQRLCRQSVLLWPHQPS--GQRSFWAQLGMAL 1013


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 63/265 (23%), Positives = 97/265 (36%), Gaps = 35/265 (13%)

Query: 91   RISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLY 150
            RI     +L    T + D G YTC++RN     +  F L V+        P  +      
Sbjct: 2434 RILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVL-------VPPHIVGENTL 2486

Query: 151  IEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQ--NFNNVIPEGMNLSFLIALISNNG 208
             +  ++      +      +  P ITW+     +Q    +++I  G  L      + + G
Sbjct: 2487 EDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTG 2546

Query: 209  NYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTV 268
             YTC+ + P      H +R+ ++ V  SP  A      +P D  V    P     + C  
Sbjct: 2547 RYTCLASSPAG----HKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS---LVCEA 2599

Query: 269  YFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRT-QILSIKKVTSEDLK 327
            Y          + W  DG          T  ES  + R     RT QIL+      ED  
Sbjct: 2600 Y----SYPPATITWFKDG----------TPLESNRNIRILPGGRTLQILN----AQEDNA 2641

Query: 328  RSYVCHARSAKGEVAKAAKVKQKVP 352
              Y C A +  GE+ K  +VK  +P
Sbjct: 2642 GRYSCVATNEAGEMIKHYEVKVYIP 2666



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 35/133 (26%), Positives = 55/133 (41%), Gaps = 12/133 (9%)

Query: 98   VLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQR 157
            +L    T + D G Y C+  NT   +K  F L V    S      +   +   +      
Sbjct: 2927 ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSE---NLTVVVNNFIS 2983

Query: 158  ITCPNVDGYFPSSVKPTITWYMGCYKIQNFNN--VIPEGMNLSFLIALISNNGNYTCVVT 215
            +TC  V G+ P    P ++W      I+   N  ++P G  L  + A +S+ G YTC+  
Sbjct: 2984 LTC-EVSGFPP----PDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAI 3038

Query: 216  YP--ENGRTFHLT 226
                E+ + F LT
Sbjct: 3039 NQAGESKKKFSLT 3051



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 70/312 (22%), Positives = 111/312 (35%), Gaps = 79/312 (25%)

Query: 67   TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 126
            +L WY   Q    ++ +N       I+     L  +   ++DTG YTC+  N     ++ 
Sbjct: 2705 SLSWYKDGQPLKSDDHVN-------IAANGHTLQIKEAQISDTGRYTCVASNIAGEDELD 2757

Query: 127  FPLEVV----------------------QKDSCFNSPMKLPVHKLYIEYGIQRITCPNVD 164
            F + +                        KD   N+P+ L     Y E            
Sbjct: 2758 FDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISL-----YCETN---------- 2802

Query: 165  GYFPSSVKPTITWYMGCYKIQNFNNVI--PEGMNLSFLIALISNNGNYTCVVTYPENGRT 222
                ++  PT+TWY   + + + + V+  P G  L    A + + G YTCV    E G  
Sbjct: 2803 ----AAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAV-NEAGED 2857

Query: 223  FHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKE--PGEELLIPCTVYFSFLMDSRNEV 280
               +    V+V+      VPP+I   N  +  E      +  LI C    S     RN  
Sbjct: 2858 ---SLQYDVRVL------VPPIIKGANSDLPEEVTVLVNKSALIEC--LSSGSPAPRNS- 2905

Query: 281  WWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGE 340
             W  DG+      ++   ++ +S+ R      TQI  I +         YVC A +  G 
Sbjct: 2906 -WQKDGQP----LLEDDHHKFLSNGRILQILNTQITDIGR---------YVCVAENTAGS 2951

Query: 341  VAKAAKVKQKVP 352
              K   +   VP
Sbjct: 2952 AKKYFNLNVHVP 2963



 Score = 37.4 bits (85), Expect = 0.037
 Identities = 39/180 (21%), Positives = 67/180 (37%), Gaps = 14/180 (7%)

Query: 72   WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV 131
            W + D    +P+N      +I     VL    TLL D G YTC+  N    ++    L V
Sbjct: 1860 WLKDD----QPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHV 1915

Query: 132  VQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNV- 190
             +  S  ++   L  ++  +     ++ C         +  P ITWY     +    ++ 
Sbjct: 1916 HEPPSLEDAGKML--NETVLVSNPVQLECKAA-----GNPVPVITWYKDNRLLSGSTSMT 1968

Query: 191  -IPEGMNLSFLIALISNNGNYTCVVTYPENG-RTFHLTRTLTVKVVGSPKNAVPPVIHSP 248
             +  G  +    A IS+ G Y CV          F+  +      +    N V  V+++P
Sbjct: 1969 FLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNP 2028



 Score = 37.4 bits (85), Expect = 0.037
 Identities = 40/140 (28%), Positives = 59/140 (42%), Gaps = 13/140 (9%)

Query: 107  NDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGY 166
            +D+GNYTC+  N    ++  + L +    S   + +   V  L  E     + C N +G 
Sbjct: 3217 SDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGEN--VELVC-NANG- 3272

Query: 167  FPSSVKPTITWYMGCYKIQNFNN----VIPEGMNLSFLIALISNNGNYTCVVTYP--ENG 220
             P+   P I W      I +       V   G  L+   AL S+ G YTCV T P  E  
Sbjct: 3273 IPT---PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEED 3329

Query: 221  RTFHLTRTLTVKVVGSPKNA 240
            R F+L   +T  + G+   A
Sbjct: 3330 RIFNLNVYVTPTIRGNKDEA 3349



 Score = 37.0 bits (84), Expect = 0.049
 Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 12/149 (8%)

Query: 92   ISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYI 151
            I  E  +L  +   ++DTG Y C+  N    +   + L V    S   +  + P +   +
Sbjct: 2341 ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGN-HRSPENISVV 2399

Query: 152  EYGIQRITCPNVDGYFPSSVK-PTITWYMGCYKIQNFNNV--IPEGMNLSFLIALISNNG 208
            E     +TC        S +  P+ITW+   + +   N+V  +  G  L  +   + + G
Sbjct: 2400 EKNSVSLTCE------ASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAG 2453

Query: 209  NYTCVV--TYPENGRTFHLTRTLTVKVVG 235
             YTCVV     E  + F L+  +   +VG
Sbjct: 2454 QYTCVVRNAAGEERKIFGLSVLVPPHIVG 2482



 Score = 36.2 bits (82), Expect = 0.083
 Identities = 61/254 (24%), Positives = 95/254 (37%), Gaps = 49/254 (19%)

Query: 106  LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDG 165
            ++D G Y C+  N+   +++ + L+V    S   S   + V    +     R+ C     
Sbjct: 1983 ISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV----VVNNPVRLECEARG- 2037

Query: 166  YFPSSVKPTITWYMGCYKIQNFNN---VIPEGMNLSFLIALISNNGNYTCVVTYPENGRT 222
              P+   P++TW      + +F+N   V+  G  L+   A IS+ G YTCV       + 
Sbjct: 2038 -IPA---PSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEK- 2092

Query: 223  FHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWW 282
                R + ++V       VPP I     +V        ELL                + W
Sbjct: 2093 ---QRDIDLRVY------VPPNIMGEEQNVSVLISQAVELLCQSDAI------PPPTLTW 2137

Query: 283  TIDG----KKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAK 338
              DG    KKP           SIS +R+       +L I+    +D  R Y C A +  
Sbjct: 2138 LKDGHPLLKKP---------GLSISENRS-------VLKIEDAQVQDTGR-YTCEATNVA 2180

Query: 339  GEVAKAAKVKQKVP 352
            G+  K   V   VP
Sbjct: 2181 GKTEKNYNVNIWVP 2194



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 34/147 (23%), Positives = 58/147 (39%), Gaps = 9/147 (6%)

Query: 106  LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDG 165
            ++D G YTC+  N    SK  F L V    S     +K    +      ++  T  +++ 
Sbjct: 3027 VSDGGEYTCIAINQAGESKKKFSLTVYVPPS-----IKDHDSESLSVVNVREGTSVSLEC 3081

Query: 166  YFPSSVKPTITWYMGCYKIQNFNNV--IPEGMNLSFLIALISNNGNYTC--VVTYPENGR 221
               +   P ITWY     I    +V  + +G  L    A +S+ G Y C  +     + +
Sbjct: 3082 ESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDK 3141

Query: 222  TFHLTRTLTVKVVGSPKNAVPPVIHSP 248
             FHL   +   + G  +  +   I +P
Sbjct: 3142 NFHLNVYVPPSIEGPEREVIVETISNP 3168



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 65/274 (23%), Positives = 99/274 (36%), Gaps = 48/274 (17%)

Query: 89   ENRISKEKDVLWFRPTLLNDTGNYTCMLRN------TTYCSKVAFPLEVVQKDSCFNSPM 142
            E+ +S     L       +D G YTC+  N      T     V  P  V   +  +N+  
Sbjct: 1216 EHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTF 1275

Query: 143  KLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFN---NVIPEGMNLSF 199
            +  V    IE+      CP        + KPTI W     ++       +++ +G  L  
Sbjct: 1276 QERVANQRIEF-----PCP-----AKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVI 1325

Query: 200  LIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPG 259
                  +NG Y CV    E G T    R   +KV       VPPVI         +KE  
Sbjct: 1326 ASVTPYDNGEYICVAV-NEAGTT---ERKYNLKV------HVPPVIK--------DKEQ- 1366

Query: 260  EELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRT-EDETRTQILSI 318
                       S L++    ++  ++G  P  I +    N  ++ S T +     +IL +
Sbjct: 1367 -------VTNVSVLLNQLTNLFCEVEG-TPSPIIMWYKDNVQVTESSTIQTVNNGKILKL 1418

Query: 319  KKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVP 352
             + T ED  R Y C A +  G   K   +   VP
Sbjct: 1419 FRATPEDAGR-YSCKAINIAGTSQKYFNIDVLVP 1451



 Score = 34.3 bits (77), Expect = 0.32
 Identities = 32/132 (24%), Positives = 55/132 (41%), Gaps = 14/132 (10%)

Query: 92   ISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYI 151
            I  +  +L  +   ++DTG Y C   N        F L V    S     ++ P  ++ +
Sbjct: 3108 ILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPS-----IEGPEREVIV 3162

Query: 152  EYGIQRITCP-NVDGYFPSSVKPTITWYMGCYKIQNFNN----VIPEGMNLSFLIALISN 206
            E     +T   +  G  P    PTI W     +I+N ++    ++  G  L    +  S+
Sbjct: 3163 ETISNPVTLTCDATGIPP----PTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSD 3218

Query: 207  NGNYTCVVTYPE 218
            +GNYTC+ +  E
Sbjct: 3219 SGNYTCIASNME 3230



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 31/115 (26%), Positives = 44/115 (38%), Gaps = 15/115 (13%)

Query: 106  LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRIT--CPNV 163
            +++TG Y CM  NT    K  F + V    +  +S +   V   Y    +Q I    PN 
Sbjct: 1797 VSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPN- 1855

Query: 164  DGYFPSSVKPTITWYMGCYKI---QNFNNVIPEGMNLSFLIALISNNGNYTCVVT 215
                     P+ITW      +   Q    +   G  L     L+ + G YTCV T
Sbjct: 1856 ---------PSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVAT 1901



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 64/290 (22%), Positives = 101/290 (34%), Gaps = 62/290 (21%)

Query: 72   WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV 131
            W +  R + E I  R+     S    + + +P    D G+YTCM  N    S  +  L V
Sbjct: 4112 WHKDGRAIVESIRQRVLS---SGSLQIAFVQP---GDAGHYTCMAANVAGSSSTSTKLTV 4165

Query: 132  VQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITW---------YMGCY 182
                     P        Y      +   P V    P+   P I W          +G Y
Sbjct: 4166 ------HVPPRIRSTEGHYTVNENSQAILPCVADGIPT---PAINWKKDNVLLANLLGKY 4216

Query: 183  KIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVP 242
              + +  +I E +       ++ ++G YTCV     N      T T+++ V     + +P
Sbjct: 4217 TAEPYGELILENV-------VLEDSGFYTCVA----NNAAGEDTHTVSLTV-----HVLP 4260

Query: 243  PVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESI 302
                 P D        GE+L + C      L     ++ W              T N +I
Sbjct: 4261 TFTELPGD---VSLNKGEQLRLSCKATGIPL----PKLTW--------------TFNNNI 4299

Query: 303  SHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVP 352
              +  +       L I++V+ ED   +YVC A ++ G V     V  K P
Sbjct: 4300 IPAHFDSVNGHSELVIERVSKED-SGTYVCTAENSVGFVKAIGFVYVKEP 4348



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 37/155 (23%), Positives = 59/155 (38%), Gaps = 23/155 (14%)

Query: 97   DVLWFRPTLLNDTGNYTCMLRNTT------YCSKVAFPLEVVQKDSCFNSPMKLPVHKLY 150
            +VL      + DTG YTC+  +        Y  +V  P  +   D     P  + V +  
Sbjct: 3582 EVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTD----EPRDITVLR-- 3635

Query: 151  IEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNV--IPEGMNLSFLIALISNNG 208
                 +++T        P    P ITW     ++Q    V  +  G  L    A + +  
Sbjct: 3636 ----NRQVTLECKSDAVP---PPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTA 3688

Query: 209  NYTCVVT--YPENGRTFHLTRTLTVKVVGSPKNAV 241
            NYTCV +    +  R F LT  +   + G P++ V
Sbjct: 3689 NYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLV 3723



 Score = 30.4 bits (67), Expect = 4.6
 Identities = 41/178 (23%), Positives = 61/178 (34%), Gaps = 27/178 (15%)

Query: 95   EKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYG 154
            E   L  +   + DTG Y CM  N     +    L+V    S    P  + V        
Sbjct: 3764 ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTV-----IVN 3818

Query: 155  IQRITCPNVDGYFPSSVKPTITWYMGCYKI-----QNFNNVIPEGMNLSFLIALISNNGN 209
            +Q        G      KP+I W    + +     QN   ++  G +L  +   + +   
Sbjct: 3819 VQTTLACEATGI----PKPSINWRKNGHLLNVDQNQNSYRLLSSG-SLVIISPSVDDTAT 3873

Query: 210  YTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCT 267
            Y C VT          T  LTV+V        P +   P D +V +  P    +I CT
Sbjct: 3874 YECTVT--NGAGDDKRTVDLTVQV-------PPSIADEPTDFLVTKHAPA---VITCT 3919


>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
          Length = 1349

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 61/213 (28%), Positives = 86/213 (40%), Gaps = 31/213 (14%)

Query: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120
           A+   LT  WYW  ++   +  +  R+   RI  +  ++ FR     D+G YTC+  N+ 
Sbjct: 254 AYPGNLTYTWYWQDENVYFQNDLKLRV---RILIDGTLIIFR-VKPEDSGKYTCVPSNSL 309

Query: 121 YCSKVAFPLEVVQKDS-CFNSPMKLPVHKLYIEYGIQR-ITCPNVDGYFPSSVKPTITWY 178
             S  A     VQ  +   N P   PV  +Y+  GI   I CP VD   P++V   + W 
Sbjct: 310 GRSPSASAYLTVQYPARVLNMP---PV--IYVPVGIHGYIRCP-VDAEPPATV---VKWN 360

Query: 179 MGCYKIQ---NFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVG 235
                +Q   N    + E  ++    A     G YTCV   P N        TL      
Sbjct: 361 KDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCV---PYN--------TLGTMGQS 409

Query: 236 SPKNAV--PPVIHSPNDHVVYEKEPGEELLIPC 266
           +P   V   P   +      Y +E G ELLIPC
Sbjct: 410 APARLVLKDPPYFTVLPGWEYRQEAGRELLIPC 442


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 68/265 (25%), Positives = 98/265 (36%), Gaps = 55/265 (20%)

Query: 107  NDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGY 166
            +D GNYTC+  N     +    L V +  S    P  L V              P  +  
Sbjct: 5865 SDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEV-------------LPGKNVT 5911

Query: 167  FPSSVKPT----ITWYMGCYKIQN-------FNNVIPEGMNLSFLIALISNNGNYTCVVT 215
            F S ++ T    + W+ G  ++         F + + E   L      IS +G YTCVV+
Sbjct: 5912 FTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAE---LELFNIDISQSGEYTCVVS 5968

Query: 216  YPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMD 275
               N      T  L VK   +        +   +DH V   EPG+ +++  T Y   L  
Sbjct: 5969 --NNAGQASCTTRLFVKEPAA-------FLKRLSDHSV---EPGKSIILEST-YTGTLPI 6015

Query: 276  SRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHAR 335
            S   V W  DG        ++T +E  +   TE   +T IL I   T  D  + Y C   
Sbjct: 6016 S---VTWKKDG-------FNITTSEKCNIVTTE---KTCILEILNSTKRDAGQ-YSCEIE 6061

Query: 336  SAKGEVAKAAKVKQKVPAPRYTVEL 360
            +  G     A V    P P +  EL
Sbjct: 6062 NEAGRDVCGALVSTLEP-PYFVTEL 6085



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 81/337 (24%), Positives = 135/337 (40%), Gaps = 67/337 (19%)

Query: 107  NDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGY 166
            +D+G+YTC+  N     + + PL V +  S    P  + V           +T  NV   
Sbjct: 7747 SDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDV-----------LTGTNVT-- 7793

Query: 167  FPSSVKPT----ITWYMGCYKI---QNFNNVIPEGM-NLSFLIALISNNGNYTCVVTYPE 218
            F S VK T    ++W+ G  ++      N  + + +  L       S +G YTC+V+  E
Sbjct: 7794 FTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVS-NE 7852

Query: 219  NGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRN 278
             G+    T  L +K       A    +   ND   Y  E G+ L++  T    F      
Sbjct: 7853 AGKA-SCTTHLYIK-------APAKFVKRLND---YSIEKGKPLILEGT----FTGTPPI 7897

Query: 279  EVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAK 338
             V W  +G       I+VT ++  + + TE   ++ IL I   T ED  + Y C+  +A 
Sbjct: 7898 SVTWKKNG-------INVTPSQRCNITTTE---KSAILEIPSSTVEDAGQ-YNCYIENAS 7946

Query: 339  GEVAKAAKVKQKVPAPRY------TVELACGFGATVLLVVILIVVYHVYW------LEMV 386
            G+ + +A++   +  P Y       V+++ G  A++   +       V W      L   
Sbjct: 7947 GKDSCSAQI--LILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPT 8004

Query: 387  LFYRAHFGTDETILDGKEYDI-----YVSYARNAEEE 418
              Y+ HF  +   L   + DI     Y+  A N+  E
Sbjct: 8005 TTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGE 8041



 Score = 33.9 bits (76), Expect = 0.41
 Identities = 40/165 (24%), Positives = 64/165 (38%), Gaps = 33/165 (20%)

Query: 66   LTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNT--TYCS 123
            +T+ WY  + D  L     +R      +     L F    +ND+G YTC   N+  T  S
Sbjct: 6108 ITVSWY--KGDTKLRPTPEYR---TYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASS 6162

Query: 124  KVAFPLEVVQKDSCFNSPMK-------LPVHKLYIEYGIQRITCPNVDGYFPSSVKPTIT 176
            K  F ++  Q    F   +K       LPV           +TC  ++G  P  V     
Sbjct: 6163 KTVFRIQERQLPPSFARQLKDIEQTVGLPV----------TLTC-RLNGSAPIQV----C 6207

Query: 177  WYMGCYKIQNFNNV----IPEGMNLSFLIALISNNGNYTCVVTYP 217
            WY     +++  N+    +     L  L   +S++G Y+C  + P
Sbjct: 6208 WYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNP 6252



 Score = 30.0 bits (66), Expect = 6.0
 Identities = 29/119 (24%), Positives = 47/119 (39%), Gaps = 13/119 (10%)

Query: 106  LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDG 165
            +ND GN+TC   N+      +  L V +  S    P    V             C  +  
Sbjct: 4177 MNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLP-------GSAVC--LKS 4227

Query: 166  YFPSSVKPTITWYMGCYKIQNFNN--VIPEGMNLSFLIALI--SNNGNYTCVVTYPENG 220
             F  S   TI W+ G  ++ +  +  +  E +  S  + L+  S++G YTC V+    G
Sbjct: 4228 TFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGG 4286


>gi|20302168 toll-like receptor 8 [Homo sapiens]
          Length = 1041

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 36/186 (19%), Positives = 81/186 (43%), Gaps = 19/186 (10%)

Query: 370  LVVILIVVYHVYWLEMVLFYRA---------HFGTDETILDGKEYDIYVSY-ARNAEEEE 419
            +V++  + +H+++ ++   Y              T +T      YD Y+SY  ++A   +
Sbjct: 841  MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTF-----YDAYISYDTKDASVTD 895

Query: 420  FVLLTLRGVLEN--EFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGT 477
            +V+  LR  LE   +    LC+ +RD  PG  + D  +  I +S++ + VL+  Y     
Sbjct: 896  WVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWN 955

Query: 478  QALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGR 537
                   A    M    ++ + ++    ++ ++   L++     ++++W        +G 
Sbjct: 956  FKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPK--AEGL 1013

Query: 538  FWKQLQ 543
            FW+ L+
Sbjct: 1014 FWQTLR 1019


>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
          Length = 698

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 52/196 (26%), Positives = 75/196 (38%), Gaps = 31/196 (15%)

Query: 87  LPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPV 146
           L  +RI  E+  L      L+D G Y C+  N          L V+     F+  +    
Sbjct: 29  LTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTL---- 84

Query: 147 HKLYIEYGIQRITCPNVDGYF------PSSVKPTITWYMGCYKI-QNFNNVIPEGMNLSF 199
                   ++R+T   V G         +S KP  TW  G   + +N    I E  NL  
Sbjct: 85  --------LKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRI 136

Query: 200 LIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPG 259
           +    S+ G+YTC+ T   +  T   T  L VK     +  VPP   S  D  V     G
Sbjct: 137 INVTKSDAGSYTCIAT--NHFGTASSTGNLVVK--DPTRVMVPP---SSMDVTV-----G 184

Query: 260 EELLIPCTVYFSFLMD 275
           E +++PC V     +D
Sbjct: 185 ESIVLPCQVTHDHSLD 200


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 52/196 (26%), Positives = 75/196 (38%), Gaps = 31/196 (15%)

Query: 87  LPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPV 146
           L  +RI  E+  L      L+D G Y C+  N          L V+     F+  +    
Sbjct: 357 LTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTL---- 412

Query: 147 HKLYIEYGIQRITCPNVDGYF------PSSVKPTITWYMGCYKI-QNFNNVIPEGMNLSF 199
                   ++R+T   V G         +S KP  TW  G   + +N    I E  NL  
Sbjct: 413 --------LKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRI 464

Query: 200 LIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPG 259
           +    S+ G+YTC+ T   +  T   T  L VK     +  VPP   S  D  V     G
Sbjct: 465 INVTKSDAGSYTCIAT--NHFGTASSTGNLVVK--DPTRVMVPP---SSMDVTV-----G 512

Query: 260 EELLIPCTVYFSFLMD 275
           E +++PC V     +D
Sbjct: 513 ESIVLPCQVTHDHSLD 528



 Score = 34.3 bits (77), Expect = 0.32
 Identities = 63/236 (26%), Positives = 89/236 (37%), Gaps = 31/236 (13%)

Query: 37  VFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEK 96
           +F  EP+ +  PL     K   +            W     D++  ++FR        E 
Sbjct: 27  IFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSV----VEG 82

Query: 97  DVLWFRPTLLNDTGNYTCMLRNT--TYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYG 154
            +L   P    D G Y C   N+  T  S+ A  L+    D+ F +  +  V    +  G
Sbjct: 83  SLLINNPNKTQDAGTYQCTATNSFGTIVSREA-KLQFAYLDN-FKTRTRSTVS---VRRG 137

Query: 155 IQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNN--VIPEGMNLSFLIALISNNGNYTC 212
              +    + G  P S + +  W    Y     N   V  E  NL       S+ GNYTC
Sbjct: 138 QGMVL---LCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTC 194

Query: 213 VVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTV 268
           VVT   N  T H       KV+G P    P ++   ND V+ E EP  E+  P TV
Sbjct: 195 VVT---NTVTNH-------KVLGPP---TPLILR--NDGVMGEYEPKIEVQFPETV 235


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,616,118
Number of Sequences: 37866
Number of extensions: 983861
Number of successful extensions: 2728
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 2415
Number of HSP's gapped (non-prelim): 302
length of query: 570
length of database: 18,247,518
effective HSP length: 108
effective length of query: 462
effective length of database: 14,157,990
effective search space: 6540991380
effective search space used: 6540991380
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.