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Search of human proteins with 4502181
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502181 aquaporin 4 isoform a [Homo sapiens]
(323 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502181 aquaporin 4 isoform a [Homo sapiens] 653 0.0
gi|4755125 aquaporin 4 isoform b [Homo sapiens] 604 e-173
gi|4502183 aquaporin 5 [Homo sapiens] 238 5e-63
gi|6912506 major intrinsic protein of lens fiber [Homo sapiens] 237 1e-62
gi|4502179 aquaporin 2 [Homo sapiens] 233 2e-61
gi|37694062 aquaporin 1 [Homo sapiens] 216 2e-56
gi|86792455 aquaporin 6 [Homo sapiens] 196 3e-50
gi|45446752 aquaporin 8 [Homo sapiens] 117 1e-26
gi|157266307 aquaporin 9 [Homo sapiens] 87 3e-17
gi|4826645 aquaporin 3 [Homo sapiens] 83 4e-16
gi|4502187 aquaporin 7 [Homo sapiens] 83 4e-16
gi|22538420 aquaporin 10 [Homo sapiens] 69 6e-12
gi|7019415 Sec61 alpha 1 subunit [Homo sapiens] 35 0.069
gi|83921614 cytochrome b5 outer mitochondrial membrane precursor... 35 0.069
gi|217330618 Sec61 alpha form 2 isoform b [Homo sapiens] 33 0.26
gi|217330616 Sec61 alpha form 2 isoform c [Homo sapiens] 33 0.26
gi|14589847 Sec61 alpha form 2 isoform a [Homo sapiens] 33 0.26
gi|40538880 aquaporin 12A [Homo sapiens] 33 0.45
gi|50593008 transmembrane BAX inhibitor motif containing 1 [Homo... 32 0.76
gi|156447037 aquaporin 12B [Homo sapiens] 32 0.76
gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Hom... 31 1.7
gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo ... 31 1.7
gi|39995086 solute carrier family 24 member 6 [Homo sapiens] 30 2.9
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 29 4.9
gi|60460889 Myb protein P42POP [Homo sapiens] 29 6.5
gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens] 29 6.5
>gi|4502181 aquaporin 4 isoform a [Homo sapiens]
Length = 323
Score = 653 bits (1685), Expect = 0.0
Identities = 323/323 (100%), Positives = 323/323 (100%)
Query: 1 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG 60
MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
Sbjct: 1 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG 60
Query: 61 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 120
GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
Sbjct: 61 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 120
Query: 121 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 180
AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
Sbjct: 121 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 180
Query: 181 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG 240
KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
Sbjct: 181 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG 240
Query: 241 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH 300
AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
Sbjct: 241 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH 300
Query: 301 VIDVDRGEEKKGKDQSGEVLSSV 323
VIDVDRGEEKKGKDQSGEVLSSV
Sbjct: 301 VIDVDRGEEKKGKDQSGEVLSSV 323
>gi|4755125 aquaporin 4 isoform b [Homo sapiens]
Length = 301
Score = 604 bits (1557), Expect = e-173
Identities = 301/301 (100%), Positives = 301/301 (100%)
Query: 23 MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA 82
MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA
Sbjct: 1 MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA 60
Query: 83 TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV 142
TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV
Sbjct: 61 TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV 120
Query: 143 GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL 202
GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL
Sbjct: 121 GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL 180
Query: 203 FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF 262
FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF
Sbjct: 181 FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF 240
Query: 263 KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS 322
KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS
Sbjct: 241 KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS 300
Query: 323 V 323
V
Sbjct: 301 V 301
>gi|4502183 aquaporin 5 [Homo sapiens]
Length = 265
Score = 238 bits (607), Expect = 5e-63
Identities = 132/263 (50%), Positives = 170/263 (64%), Gaps = 12/263 (4%)
Query: 27 KGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQ 86
K V + AF KAV AEFLA LIFV LGS + W LP ++ I+L FGL+I T+ Q
Sbjct: 3 KEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSA---LPT-ILQIALAFGLAIGTLAQ 58
Query: 87 CFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLG 146
G +SGGHINPA+T+A++ +IS+ ++ FY+AAQ +GAI GAGILY V P + G L
Sbjct: 59 ALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLA 118
Query: 147 VTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAIN 206
V ++ N T G ++VELI+TFQL IFAS DS+RT GS AL+IG SV +GHL I
Sbjct: 119 VNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIY 178
Query: 207 YTGASMNPARSFGPAVIMGNWE-NHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEA 265
+TG SMNPARSFGPAV+M + HW++WVGPI+GAVLA LY Y+ P+ +
Sbjct: 179 FTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPN-------SLS 231
Query: 266 FSKAAQQTKGSYMEVEDNRSQVE 288
S+ KG+Y ED Q E
Sbjct: 232 LSERVAIIKGTYEPDEDWEEQRE 254
>gi|6912506 major intrinsic protein of lens fiber [Homo sapiens]
Length = 263
Score = 237 bits (604), Expect = 1e-62
Identities = 113/255 (44%), Positives = 168/255 (65%), Gaps = 11/255 (4%)
Query: 33 AFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHIS 92
+FW+A+ AEF A L +V LGS++ W P P+ ++ +++ FGL++AT+VQ GHIS
Sbjct: 8 SFWRAIFAEFFATLFYVFFGLGSSLRWA----PGPLHVLQVAMAFGLALATLVQSVGHIS 63
Query: 93 GGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHG 152
G H+NPAVT A + ++S+ ++ Y+AAQ LGA+ GA +LY VTPP+V G L + +H
Sbjct: 64 GAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHP 123
Query: 153 NLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASM 212
++ G VE+ +T Q V IFA+ D +R GS+ALA+GFS+A+GHLF + YTGA M
Sbjct: 124 AVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGM 183
Query: 213 NPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQ 272
NPARSF PA++ GN+ NHW+YWVGPIIG L LY+++ P + ++ S+
Sbjct: 184 NPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRL-------KSISERLSV 236
Query: 273 TKGSYMEVEDNRSQV 287
KG+ +V + + +V
Sbjct: 237 LKGAKPDVSNGQPEV 251
>gi|4502179 aquaporin 2 [Homo sapiens]
Length = 271
Score = 233 bits (593), Expect = 2e-61
Identities = 114/222 (51%), Positives = 154/222 (69%), Gaps = 4/222 (1%)
Query: 33 AFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHIS 92
AF +AV AEFLA L+FV LGS +NW + LP ++ I++ FGL I T+VQ GHIS
Sbjct: 8 AFSRAVFAEFLATLLFVFFGLGSALNW---PQALP-SVLQIAMAFGLGIGTLVQALGHIS 63
Query: 93 GGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHG 152
G HINPAVTVA + +S+ ++ FY+AAQ LGA+ GA +L+ +TP + G L V +
Sbjct: 64 GAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSN 123
Query: 153 NLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASM 212
+ TAG + VEL +T QLV IFAS D +R + G+ AL+IGFSVA+GHL I+YTG SM
Sbjct: 124 STTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSM 183
Query: 213 NPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCP 254
NPARS PAV+ G +++HW++W+GP++GA+L LY YV P
Sbjct: 184 NPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFP 225
>gi|37694062 aquaporin 1 [Homo sapiens]
Length = 269
Score = 216 bits (550), Expect = 2e-56
Identities = 109/224 (48%), Positives = 148/224 (66%), Gaps = 3/224 (1%)
Query: 34 FWKAVTAEFLAMLIFVLLSLGSTINWG---GTEKPLPVDMVLISLCFGLSIATMVQCFGH 90
FW+AV AEFLA +FV +S+GS + + G + D V +SL FGLSIAT+ Q GH
Sbjct: 10 FWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGH 69
Query: 91 ISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMV 150
ISG H+NPAVT+ ++ + +ISI +++ YI AQC+GAI+ IL +T LG +
Sbjct: 70 ISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDL 129
Query: 151 HGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGA 210
+ +G GL +E+I T QLV + A+ D +R D+ GS LAIG SVA+GHL AI+YTG
Sbjct: 130 ADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGC 189
Query: 211 SMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCP 254
+NPARSFG AVI N+ NHWI+WVGP IG LA +Y+++ P
Sbjct: 190 GINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAP 233
>gi|86792455 aquaporin 6 [Homo sapiens]
Length = 282
Score = 196 bits (497), Expect = 3e-50
Identities = 103/228 (45%), Positives = 148/228 (64%), Gaps = 12/228 (5%)
Query: 35 WKAVT----AEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVL-ISLCFGLSIATMVQCFG 89
WKA++ AEFLA ++V +GS + W P + VL I++ F L A VQ
Sbjct: 20 WKAISRALFAEFLATGLYVFFGVGSVMRW-----PTALPSVLQIAITFNLVTAMAVQVTW 74
Query: 90 HISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTM 149
SG H NPAVT+A + IS+ ++V Y+AAQ +GA +GA +LY V P + LG+ +
Sbjct: 75 KASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINV 134
Query: 150 VHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTG 209
V +++ G + VEL++T QLV +FAS DS++T +GS A IG SVA+GHL I++TG
Sbjct: 135 VRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQT--SGSPATMIGISVALGHLIGIHFTG 192
Query: 210 ASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVE 257
SMNPARSFGPA+I+G + HW++WVGP++GA+LA +Y +V PD +
Sbjct: 193 CSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTK 240
>gi|45446752 aquaporin 8 [Homo sapiens]
Length = 261
Score = 117 bits (294), Expect = 1e-26
Identities = 74/221 (33%), Positives = 116/221 (52%), Gaps = 13/221 (5%)
Query: 30 WTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFG 89
W + F + E L +F+ + S I GT+ L + L GL IAT+ G
Sbjct: 30 WYERFVQPCLVELLGSALFIFIGCLSVIE-NGTDTGLLQPALAHGLALGLVIATL----G 84
Query: 90 HISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPP----SVVGGL 145
+ISGGH NPAV++A + +++ + Y +Q LG ++GA + V+P + G
Sbjct: 85 NISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAA 144
Query: 146 GVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-LAIGFSVAIGHLFA 204
VT+ AG L+ E+I+T L + +++T G +A +IGF+V + L
Sbjct: 145 FVTVQEQGQVAG-ALVAEIILTTLLALAVCMGAINEKTK--GPLAPFSIGFAVTVDILAG 201
Query: 205 INYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAG 245
+G MNPAR+FGPAV+ +W HWIYW+GP++ +L G
Sbjct: 202 GPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLLVG 242
>gi|157266307 aquaporin 9 [Homo sapiens]
Length = 295
Score = 86.7 bits (213), Expect = 3e-17
Identities = 77/269 (28%), Positives = 118/269 (43%), Gaps = 49/269 (18%)
Query: 36 KAVTAEFLAMLIFVLLSLG-------STINWGGTEKPLPVDMVLISLCFGLSIATMVQCF 88
K +EFL I ++L G S +GG ++ I++ F +++A +
Sbjct: 24 KETLSEFLGTFILIVLGCGCVAQAILSRGRFGG--------VITINVGFSMAVAMAIYVA 75
Query: 89 GHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGA----GILY---------- 134
G +SGGHINPAV++AM ++ K FY+ AQ LGA +GA GI Y
Sbjct: 76 GGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGK 135
Query: 135 -LVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDV-TGSIALA 192
L+ + + T L+ + +++ T L+ +FA DS+ G +A
Sbjct: 136 LLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIA 195
Query: 193 IG-FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNW---------ENHWIYWVGPIIG 240
IG + I +N +G +MNPAR P + + W WI VGP++G
Sbjct: 196 IGLLIIVIASSLGLN-SGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVG 254
Query: 241 AVLAGGLYEYVF-----CPDVEFKRRFKE 264
AV+ G +Y V PD FK E
Sbjct: 255 AVIGGLIYVLVIEIHHPEPDSVFKTEQSE 283
>gi|4826645 aquaporin 3 [Homo sapiens]
Length = 292
Score = 82.8 bits (203), Expect = 4e-16
Identities = 72/242 (29%), Positives = 107/242 (44%), Gaps = 38/242 (15%)
Query: 40 AEFLAMLIFVLLSLGST---INWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHI 96
AE L LI V+ GS + GT + I+L FG ++ + G +SG H+
Sbjct: 27 AECLGTLILVMFGCGSVAQVVLSRGTHG----GFLTINLAFGFAVTLGILIAGQVSGAHL 82
Query: 97 NPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILY---------------LVTPPSV 141
NPAVT AM + K Y AQ LGA +GAGI++ V+ P+
Sbjct: 83 NPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNG 142
Query: 142 VGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDV-TGSIALAIGFSV-AI 199
G+ T G+L +G + I T L+ + A D V G A +G V I
Sbjct: 143 TAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVI 202
Query: 200 GHLFAINYTGASMNPARSFGPAVI--MGNWEN-------HWIYW---VGPIIGAVLAGGL 247
G N +G ++NPAR FGP + + W + HW +W V P++G++ +
Sbjct: 203 GTSMGFN-SGYAVNPARDFGPRLFTALAGWGSAVFTTGQHW-WWVPIVSPLLGSIAGVFV 260
Query: 248 YE 249
Y+
Sbjct: 261 YQ 262
>gi|4502187 aquaporin 7 [Homo sapiens]
Length = 342
Score = 82.8 bits (203), Expect = 4e-16
Identities = 66/236 (27%), Positives = 104/236 (44%), Gaps = 29/236 (12%)
Query: 40 AEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPA 99
AEF++ + ++ LGS + +K + ++L FG + V G ISG H+N A
Sbjct: 39 AEFMSTYVMMVFGLGSVAHMVLNKKY--GSYLGVNLGFGFGVTMGVHVAGRISGAHMNAA 96
Query: 100 VTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILY---------------LVTPPSVVGG 144
VT A ++ K Y+ Q LG+ + A +Y +VT P G
Sbjct: 97 VTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAG 156
Query: 145 LGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTD-VTGSIALAIGFSVAIGHLF 203
+ T + ++T G L E +T L +FA D + + G+ AL IG V I +
Sbjct: 157 IFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILVVIIGVS 216
Query: 204 AINYTGASMNPARSFGPAV----------IMGNWEN-HWIYWVGPIIGAVLAGGLY 248
TG ++NP+R P + + N EN W+ V P++GA L G +Y
Sbjct: 217 LGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIY 272
>gi|22538420 aquaporin 10 [Homo sapiens]
Length = 301
Score = 68.9 bits (167), Expect = 6e-12
Identities = 58/244 (23%), Positives = 97/244 (39%), Gaps = 42/244 (17%)
Query: 40 AEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPA 99
AEFL + + +LL+ G+ T + + L L++ + G++SG H+NPA
Sbjct: 26 AEFLGVFVLMLLTQGAVAQ-AVTSGETKGNFFTMFLAGSLAVTIAIYVGGNVSGAHLNPA 84
Query: 100 VTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYL---------------VTPPSVVGG 144
++AM ++ K YI Q L A +G Y+ VT P
Sbjct: 85 FSLAMCIVGRLPWVKLPIYILVQLLSAFCASGATYVLYHDALQNYTGGNLTVTGPKETAS 144
Query: 145 LGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTD--------VTGSIALAIGFS 196
+ T L+ +G L +++ T L+ + A D + V G + LA+G S
Sbjct: 145 IFATYPAPYLSLNNGFLDQVLGTGMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLS 204
Query: 197 VAIGHLFAINYTGASMNPARSFGPAVI--MGNWENH---------WIYWVGPIIGAVLAG 245
+ G +NPAR GP + + W W+ V P++GA +
Sbjct: 205 MGAN-------CGIPLNPARDLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGT 257
Query: 246 GLYE 249
Y+
Sbjct: 258 ATYQ 261
Score = 28.9 bits (63), Expect = 6.5
Identities = 32/129 (24%), Positives = 49/129 (37%), Gaps = 33/129 (25%)
Query: 119 IAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASC 178
+A QCL +G +L L+T +V + GN FT+F
Sbjct: 20 LARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNF-----------------FTMF--- 59
Query: 179 DSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVI-MGNWENHWIYWVGP 237
+ GS+A+ I V N +GA +NPA S ++ W IY +
Sbjct: 60 ------LAGSLAVTIAIYV------GGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQ 107
Query: 238 IIGAVLAGG 246
++ A A G
Sbjct: 108 LLSAFCASG 116
>gi|7019415 Sec61 alpha 1 subunit [Homo sapiens]
Length = 476
Score = 35.4 bits (80), Expect = 0.069
Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Query: 110 ISIAKSVFYIAAQCLG--AIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGL--LVELI 165
I+I +S+ Y+ G + +GAGI L+T V GL V ++ L G+GL + L
Sbjct: 123 ITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLF 182
Query: 166 ITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFA 204
I + TI S T TG G +A+ HL A
Sbjct: 183 IATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLA 221
>gi|83921614 cytochrome b5 outer mitochondrial membrane precursor
[Homo sapiens]
Length = 150
Score = 35.4 bits (80), Expect = 0.069
Identities = 14/20 (70%), Positives = 15/20 (75%)
Query: 231 WIYWVGPIIGAVLAGGLYEY 250
W YW+ PIIGAVL G LY Y
Sbjct: 123 WAYWILPIIGAVLLGFLYRY 142
>gi|217330618 Sec61 alpha form 2 isoform b [Homo sapiens]
Length = 454
Score = 33.5 bits (75), Expect = 0.26
Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 4/99 (4%)
Query: 110 ISIAKSVFYIAAQCLG--AIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGL--LVELI 165
I+I +++ Y+ G A +GAGI L+ V GL V ++ L G+GL + L
Sbjct: 101 ITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLF 160
Query: 166 ITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFA 204
I + TI S T TG G +A+ HL A
Sbjct: 161 IATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLA 199
>gi|217330616 Sec61 alpha form 2 isoform c [Homo sapiens]
Length = 437
Score = 33.5 bits (75), Expect = 0.26
Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 4/99 (4%)
Query: 110 ISIAKSVFYIAAQCLG--AIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGL--LVELI 165
I+I +++ Y+ G A +GAGI L+ V GL V ++ L G+GL + L
Sbjct: 123 ITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLF 182
Query: 166 ITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFA 204
I + TI S T TG G +A+ HL A
Sbjct: 183 IATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLA 221
>gi|14589847 Sec61 alpha form 2 isoform a [Homo sapiens]
Length = 476
Score = 33.5 bits (75), Expect = 0.26
Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 4/99 (4%)
Query: 110 ISIAKSVFYIAAQCLG--AIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGL--LVELI 165
I+I +++ Y+ G A +GAGI L+ V GL V ++ L G+GL + L
Sbjct: 123 ITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLF 182
Query: 166 ITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFA 204
I + TI S T TG G +A+ HL A
Sbjct: 183 IATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLA 221
>gi|40538880 aquaporin 12A [Homo sapiens]
Length = 295
Score = 32.7 bits (73), Expect = 0.45
Identities = 46/189 (24%), Positives = 75/189 (39%), Gaps = 18/189 (9%)
Query: 71 VLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGA 130
+L++L F L +A V + G NP V++ + S+ ++ +AAQ LG
Sbjct: 59 LLLTLLFLLFLAHGVT----LDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAAC 114
Query: 131 GILYL-----VTPPSVVGGLGVTMVHGNLTAG--HGLLVELIITFQLVFTIFASCDSKRT 183
++ L ++ ++ L L HG LVE F T+ S
Sbjct: 115 TLMRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPA 174
Query: 184 DVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNW---ENHWIYWVGPIIG 240
++AL V + A +T A NPA + E +YW+GP+ G
Sbjct: 175 YSGPAVALL----VTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTG 230
Query: 241 AVLAGGLYE 249
VLA L++
Sbjct: 231 MVLAVLLHQ 239
>gi|50593008 transmembrane BAX inhibitor motif containing 1 [Homo
sapiens]
Length = 311
Score = 32.0 bits (71), Expect = 0.76
Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 9/82 (10%)
Query: 61 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 120
G + P +++L++L F ++ M G IS + AV +AM+ T +SI+ ++F
Sbjct: 156 GPRRRFPWNIILLTL-FTFAMGFMT---GTISSMYQTKAVIIAMIITAVVSISVTIFCFQ 211
Query: 121 AQ-----CLGAIIGAGILYLVT 137
+ C G GI+ LVT
Sbjct: 212 TKVDFTSCTGLFCVLGIVLLVT 233
>gi|156447037 aquaporin 12B [Homo sapiens]
Length = 307
Score = 32.0 bits (71), Expect = 0.76
Identities = 54/224 (24%), Positives = 85/224 (37%), Gaps = 22/224 (9%)
Query: 36 KAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGH 95
+AV A L + +L W G P +L++L F L +A V + G
Sbjct: 40 EAVGAVQLGACFLEMRTLVELGPWAGDFGP----DLLLTLLFLLFLAHGVT----LDGAS 91
Query: 96 INPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYL-----VTPPSVVGGLGVTMV 150
NP V++ + S+ ++ +AAQ LG + L ++ ++ L
Sbjct: 92 ANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQAACTLTRLCWAWELSDLHLLQSLMAQSC 151
Query: 151 HGNLTAG--HGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYT 208
L HG LVE F T+ S ++AL V + A +T
Sbjct: 152 SSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALL----VTVTAYTAGPFT 207
Query: 209 GASMNPARSFGPAVIMGNW---ENHWIYWVGPIIGAVLAGGLYE 249
A NPA + E +YW+GP+ G VLA L++
Sbjct: 208 SAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQ 251
>gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Homo
sapiens]
Length = 1134
Score = 30.8 bits (68), Expect = 1.7
Identities = 13/37 (35%), Positives = 22/37 (59%)
Query: 132 ILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITF 168
I+Y V PS+ G+T +H + AGH +V+ ++ F
Sbjct: 951 IIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQF 987
>gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo
sapiens]
Length = 1005
Score = 30.8 bits (68), Expect = 1.7
Identities = 13/37 (35%), Positives = 22/37 (59%)
Query: 132 ILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITF 168
I+Y V PS+ G+T +H + AGH +V+ ++ F
Sbjct: 822 IIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQF 858
>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
Length = 584
Score = 30.0 bits (66), Expect = 2.9
Identities = 24/84 (28%), Positives = 40/84 (47%), Gaps = 9/84 (10%)
Query: 112 IAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLV 171
+A S + A LGA+ GAG+L +VV G G+T++H + A +++ V
Sbjct: 159 VAFSDPHTAGLALGALFGAGVLV----TTVVAG-GITILHPFMAASRPFFRDIVFYMVAV 213
Query: 172 FTIFASCDSKRTDVTGSIALAIGF 195
F F R ++A A+G+
Sbjct: 214 FLTFLMLFRGRV----TLAWALGY 233
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 29.3 bits (64), Expect = 4.9
Identities = 29/90 (32%), Positives = 39/90 (43%), Gaps = 13/90 (14%)
Query: 145 LGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFA 204
LG M+ LT LV L ++ T FASC S S L IG +++ +LF
Sbjct: 536 LGSWMIR--LTVWFIFLVALFFNLLVILTTFASCTS-----LPSSKLFIGL-ISVSNLFM 587
Query: 205 INYTGASMNPARSFGPAVIMGNWENHWIYW 234
YTG +F AV G + I+W
Sbjct: 588 GIYTG-----ILTFLDAVSWGRFAEFGIWW 612
>gi|60460889 Myb protein P42POP [Homo sapiens]
Length = 399
Score = 28.9 bits (63), Expect = 6.5
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 257 EFKRRFKEAFSKAAQQTKGSYMEVEDNRS-QVETDDLILKPGV 298
+FKRR KE ++ T+G+ ED S + ET IL PGV
Sbjct: 82 DFKRRTKEKLARVPHSTQGAGPAAEDAFSAEEETIFAILGPGV 124
>gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens]
Length = 1090
Score = 28.9 bits (63), Expect = 6.5
Identities = 13/37 (35%), Positives = 21/37 (56%)
Query: 132 ILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITF 168
I+Y V PS G+T +H + AGH +V+ ++ F
Sbjct: 907 IIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDF 943
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,727,738
Number of Sequences: 37866
Number of extensions: 470615
Number of successful extensions: 1272
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1231
Number of HSP's gapped (non-prelim): 30
length of query: 323
length of database: 18,247,518
effective HSP length: 102
effective length of query: 221
effective length of database: 14,385,186
effective search space: 3179126106
effective search space used: 3179126106
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.