Search of human proteins with 126517478

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|126517478 peroxidasin homolog-like [Homo sapiens]
         (1463 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|126517478 peroxidasin homolog-like [Homo sapiens]                 3015   0.0  
gi|109150416 peroxidasin [Homo sapiens]                              1819   0.0  
gi|28558982 thyroid peroxidase isoform a [Homo sapiens]               474   e-133
gi|28558988 thyroid peroxidase isoform d [Homo sapiens]               474   e-133
gi|4503595 eosinophil peroxidase [Homo sapiens]                       450   e-126
gi|4557759 myeloperoxidase [Homo sapiens]                             438   e-122
gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens]    398   e-110
gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens]   395   e-109
gi|28558984 thyroid peroxidase isoform b [Homo sapiens]               393   e-109
gi|28558990 thyroid peroxidase isoform e [Homo sapiens]               224   5e-58
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   220   9e-57
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...   212   2e-54
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...   212   2e-54
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...   199   2e-50
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     193   1e-48
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      193   1e-48
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    188   4e-47
gi|224994171 roundabout 1 isoform c [Homo sapiens]                    188   4e-47
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...   188   4e-47
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ...   188   4e-47
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...   185   3e-46
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   184   7e-46
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   184   7e-46
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   175   3e-43
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]        174   4e-43
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   174   6e-43
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   174   7e-43
gi|118572606 hemicentin 1 [Homo sapiens]                              174   7e-43
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi...   158   4e-38
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]      153   1e-36

>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 3015 bits (7816), Expect = 0.0
 Identities = 1463/1463 (100%), Positives = 1463/1463 (100%)

Query: 1    MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFN 60
            MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFN
Sbjct: 1    MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFN 60

Query: 61   RIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKG 120
            RIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKG
Sbjct: 61   RIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKG 120

Query: 121  LISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSN 180
            LISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSN
Sbjct: 121  LISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSN 180

Query: 181  ALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEP 240
            ALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEP
Sbjct: 181  ALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEP 240

Query: 241  QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ 300
            QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ
Sbjct: 241  QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ 300

Query: 301  GVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPL 360
            GVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPL
Sbjct: 301  GVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPL 360

Query: 361  ITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQ 420
            ITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQ
Sbjct: 361  ITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQ 420

Query: 421  FTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ 480
            FTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ
Sbjct: 421  FTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ 480

Query: 481  HDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQP 540
            HDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQP
Sbjct: 481  HDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQP 540

Query: 541  IITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAI 600
            IITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAI
Sbjct: 541  IITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAI 600

Query: 601  QGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMAR 660
            QGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMAR
Sbjct: 601  QGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMAR 660

Query: 661  AGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSN 720
            AGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSN
Sbjct: 661  AGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSN 720

Query: 721  RCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPP 780
            RCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPP
Sbjct: 721  RCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPP 780

Query: 781  RLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDP 840
            RLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDP
Sbjct: 781  RLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDP 840

Query: 841  PCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVY 900
            PCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVY
Sbjct: 841  PCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVY 900

Query: 901  GSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHR 960
            GSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHR
Sbjct: 901  GSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHR 960

Query: 961  ANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPK 1020
            ANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPK
Sbjct: 961  ANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPK 1020

Query: 1021 VLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLP 1080
            VLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLP
Sbjct: 1021 VLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLP 1080

Query: 1081 FHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAAT 1140
            FHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAAT
Sbjct: 1081 FHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAAT 1140

Query: 1141 IIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPAL 1200
            IIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPAL
Sbjct: 1141 IIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPAL 1200

Query: 1201 MVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDN 1260
            MVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDN
Sbjct: 1201 MVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDN 1260

Query: 1261 GDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRS 1320
            GDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRS
Sbjct: 1261 GDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRS 1320

Query: 1321 AQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALR 1380
            AQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALR
Sbjct: 1321 AQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALR 1380

Query: 1381 EQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPE 1440
            EQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPE
Sbjct: 1381 EQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPE 1440

Query: 1441 LVKGTCCPVCRDRGMPSDSPEKR 1463
            LVKGTCCPVCRDRGMPSDSPEKR
Sbjct: 1441 LVKGTCCPVCRDRGMPSDSPEKR 1463


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 1819 bits (4711), Expect = 0.0
 Identities = 888/1458 (60%), Positives = 1090/1458 (74%), Gaps = 17/1458 (1%)

Query: 5    LFC-WTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIR 63
            LFC W TL ++A    PG  CPSRCLCF++TVRCMHL+L+ +P V  QT++LDLRFNRIR
Sbjct: 18   LFCAWGTLAVVAQ--KPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIR 75

Query: 64   EIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLIS 123
            EI   AF++L+NLNTLLLNNN I++I   AFE LENL YLYLYKNEI ++D+Q FKGL S
Sbjct: 76   EIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLAS 135

Query: 124  LEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALV 183
            LE LY+HFNQ+E L P++F  L +LERLFLHNN+++ +  G+F++L+S+KRLRLDSN L 
Sbjct: 136  LEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLH 195

Query: 184  CDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDV 243
            CDC+++WL +LL+ +A+ G+ QAAA CEYPRR+ GR+VA++T EE NC+ PRIT EPQD 
Sbjct: 196  CDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDA 255

Query: 244  EVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVY 303
            +V SGNTVYFTCRAEGNPKPEIIW+ NN+ L ++ D+RLN+ DDGTLMI+NT+E+DQG+Y
Sbjct: 256  DVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIY 315

Query: 304  QCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITW 363
            QCMA+N AGE KTQ   LRY   PA+P+FVIQPQ+TEVL+G S TLEC ATGHP P I+W
Sbjct: 316  QCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISW 375

Query: 364  TRDNG--LELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQF 421
            TR +   L +D   ++  S GLY+QN+ Q D G + C A N+  +V A A IIVQA PQF
Sbjct: 376  TRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQF 435

Query: 422  TVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQH 481
            TVTP+D+VV+E   V++ CEA GNPPPVI WTK G QL V+ +H VLSSGTLRI   A H
Sbjct: 436  TVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALH 495

Query: 482  DQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPI 541
            DQGQYECQAV+ +G +KV   LTV+P+   VF  +P DT+VEVG N+ + C +QGEP+P 
Sbjct: 496  DQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPA 555

Query: 542  ITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQ 601
            ITWNK+GVQ+TESGKFH+  EG LTI D G  D GRYECVARN+ G A  +M L+V    
Sbjct: 556  ITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPD 615

Query: 602  GRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARA 661
              + GD FV +SI++A+  VD AINSTR HLF  +P + +DLLA F YPRDP  VE ARA
Sbjct: 616  VSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARA 675

Query: 662  GEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNR 721
            GEIFE TLQLI+E V+ GL VDL G  + YNDLVSP+ L+LIANLSGCTA R + NCS+ 
Sbjct: 676  GEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDM 735

Query: 722  CFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLP-VGSRQPLPPP 780
            CFH KYR HDGTCNNLQ P WGA+LTAF RLL+  Y +G   PRG+    + +   LP P
Sbjct: 736  CFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMP 795

Query: 781  RLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDP 840
            RLV+T       VTPD  +T MLM WG FL+HDLD TV ALS ARFSDG+ CS+VC+NDP
Sbjct: 796  RLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDP 855

Query: 841  PCFPMNTRHADPRG-THAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNV 899
            PCF +     D R  + A CM F RSSP C SG  S  ++SVY REQINQ T+YID SNV
Sbjct: 856  PCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNV 915

Query: 900  YGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESP--CFLAG 957
            YGS+E E++++RD +  RGLL+ G     SGKPLLPF+TGPPTEC R E ESP  CFLAG
Sbjct: 916  YGSTEHEARSIRDLASHRGLLRQGIV-QRSGKPLLPFATGPPTECMRDENESPIPCFLAG 974

Query: 958  DHRANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHW 1017
            DHRANE L L +MHTLWFREHNR+ATEL  LNPHW+G+T+Y E RKIVGAE+QHITY HW
Sbjct: 975  DHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHW 1034

Query: 1018 LPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEG 1077
            LPK+LG+ G R L  Y GY+P +NAGI N+FATAAFRFGHTL+NP+LYRL+     I++ 
Sbjct: 1035 LPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQD 1094

Query: 1078 HLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDS 1137
            HLP HKA FSP RI+ EGGIDP+LRGLFGVA K R PS LL+ ELT+RLFS A++ A+D 
Sbjct: 1095 HLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDL 1154

Query: 1138 AATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLW 1197
            AA  IQRGRDHGIPPY D+RV+CNL++   FEDL+NEIK+ EIR+KL++LYGS  +IDL+
Sbjct: 1155 AAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLF 1214

Query: 1198 PALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVL 1257
            PAL+VEDL+PG+R+GPTLMCL  TQF+RLRDGDR WYENPGVF+PAQLTQ+KQ SL+R+L
Sbjct: 1215 PALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQTSLARIL 1274

Query: 1258 CDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQK 1317
            CDN D+I +VQ+DVF  AE+P  Y +C EIP+VDLRVWQDCC DCR+RGQF A +   + 
Sbjct: 1275 CDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCRTRGQFNAFSYHFRG 1334

Query: 1318 KRSAQYSYPVDKDMELSHLRSRQQDKI-YVGEDARNVTVLAKTKF----SQDFSTFAAEI 1372
            +RS ++SY  DK  + +  R R+   +   GE   N T    T+     + DF  F  E+
Sbjct: 1335 RRSLEFSYQEDKPTKKT--RPRKIPSVGRQGEHLSNSTSAFSTRSDASGTNDFREFVLEM 1392

Query: 1373 QETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICP 1432
            Q+TIT LR QI KLE+RL    C D  G       +W K+ CT C C+ GQVTC VE CP
Sbjct: 1393 QKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECKDGQVTCFVEACP 1452

Query: 1433 PAPCPSPELVKGTCCPVC 1450
            PA C  P  + G CCPVC
Sbjct: 1453 PATCAVPVNIPGACCPVC 1470


>gi|28558982 thyroid peroxidase isoform a [Homo sapiens]
          Length = 933

 Score =  474 bits (1220), Expect = e-133
 Identities = 274/704 (38%), Positives = 391/704 (55%), Gaps = 27/704 (3%)

Query: 612  SSILDAVQR-VDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQ 670
            SS+L+  +R VD+A+ +T +    ++   S   L  F    +P    +ARA EI E ++Q
Sbjct: 40   SSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQ 99

Query: 671  LIRERVKQGLTVDLEGKEFRY-NDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRA 729
             ++ +V      +L+ ++ ++  D +S   LS+IAN+SGC      P C N C   KYR 
Sbjct: 100  AMKRKV------NLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRP 153

Query: 730  HDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLP-VGSRQPLPPPRLVA--TV 786
              G CNN   P WGA+ TA AR L P Y DG   PRG     + +  PLPP R V    +
Sbjct: 154  ITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVI 213

Query: 787  WARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMN 846
                  VT D  Y+ +LM WG +++HD+  T  + S A F  G  C   C N  PCFP+ 
Sbjct: 214  QVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQ 273

Query: 847  TRHADPRGTHAPCMLFARSSPACASGRPSA---TVDSVYAREQINQQTAYIDGSNVYGSS 903
                        C+ F RSS AC +G   A    + +   R+Q+N  T+++D S VYGSS
Sbjct: 274  LPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSS 333

Query: 904  ERESQALRDPSVPRGLLKTGFPWPPSGKPLLPF-STGPPTECARQ-----EQESPCFLAG 957
                + LR+ +   GLL+       SG+  LPF     P  CA +     E   PCFLAG
Sbjct: 334  PALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAG 393

Query: 958  DHRANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHW 1017
            D RA+E  +L A+HTLW REHNR+A  L ALN HW  + VYQEARK+VGA  Q IT   +
Sbjct: 394  DGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDY 453

Query: 1018 LPKVLGDPGTRMLRG-YRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISE 1076
            +P++LG    +   G Y GY+   N  + N F+TAAFRFGH  I+P++ RL+A+  E  +
Sbjct: 454  IPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQEHPD 513

Query: 1077 GHLP---FHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSA 1133
              LP    H+A FSP  +++ GG+DP++RGL    AK +    L++ ELT+RLF  + S+
Sbjct: 514  --LPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSS 571

Query: 1134 AVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGD 1193
             +D A+  +QRGRDHG+P Y ++R FC L  ++   DL   I    +  K+  LY  P +
Sbjct: 572  TLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDN 631

Query: 1194 IDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASL 1253
            ID+W   + E+ +P  R GP   CL   Q + LRDGD FW+EN  VFT AQ  +L++ SL
Sbjct: 632  IDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSL 691

Query: 1254 SRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQD 1297
            SRV+CDN   + +V  D F   ++P+D+ +C  I  ++L  W++
Sbjct: 692  SRVICDN-TGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRE 734


>gi|28558988 thyroid peroxidase isoform d [Homo sapiens]
          Length = 889

 Score =  474 bits (1220), Expect = e-133
 Identities = 274/704 (38%), Positives = 391/704 (55%), Gaps = 27/704 (3%)

Query: 612  SSILDAVQR-VDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQ 670
            SS+L+  +R VD+A+ +T +    ++   S   L  F    +P    +ARA EI E ++Q
Sbjct: 40   SSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQ 99

Query: 671  LIRERVKQGLTVDLEGKEFRY-NDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRA 729
             ++ +V      +L+ ++ ++  D +S   LS+IAN+SGC      P C N C   KYR 
Sbjct: 100  AMKRKV------NLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRP 153

Query: 730  HDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLP-VGSRQPLPPPRLVA--TV 786
              G CNN   P WGA+ TA AR L P Y DG   PRG     + +  PLPP R V    +
Sbjct: 154  ITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVI 213

Query: 787  WARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMN 846
                  VT D  Y+ +LM WG +++HD+  T  + S A F  G  C   C N  PCFP+ 
Sbjct: 214  QVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQ 273

Query: 847  TRHADPRGTHAPCMLFARSSPACASGRPSA---TVDSVYAREQINQQTAYIDGSNVYGSS 903
                        C+ F RSS AC +G   A    + +   R+Q+N  T+++D S VYGSS
Sbjct: 274  LPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSS 333

Query: 904  ERESQALRDPSVPRGLLKTGFPWPPSGKPLLPF-STGPPTECARQ-----EQESPCFLAG 957
                + LR+ +   GLL+       SG+  LPF     P  CA +     E   PCFLAG
Sbjct: 334  PALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAG 393

Query: 958  DHRANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHW 1017
            D RA+E  +L A+HTLW REHNR+A  L ALN HW  + VYQEARK+VGA  Q IT   +
Sbjct: 394  DGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDY 453

Query: 1018 LPKVLGDPGTRMLRG-YRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISE 1076
            +P++LG    +   G Y GY+   N  + N F+TAAFRFGH  I+P++ RL+A+  E  +
Sbjct: 454  IPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQEHPD 513

Query: 1077 GHLP---FHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSA 1133
              LP    H+A FSP  +++ GG+DP++RGL    AK +    L++ ELT+RLF  + S+
Sbjct: 514  --LPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSS 571

Query: 1134 AVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGD 1193
             +D A+  +QRGRDHG+P Y ++R FC L  ++   DL   I    +  K+  LY  P +
Sbjct: 572  TLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDN 631

Query: 1194 IDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASL 1253
            ID+W   + E+ +P  R GP   CL   Q + LRDGD FW+EN  VFT AQ  +L++ SL
Sbjct: 632  IDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSL 691

Query: 1254 SRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQD 1297
            SRV+CDN   + +V  D F   ++P+D+ +C  I  ++L  W++
Sbjct: 692  SRVICDN-TGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRE 734


>gi|4503595 eosinophil peroxidase [Homo sapiens]
          Length = 715

 Score =  450 bits (1157), Expect = e-126
 Identities = 272/703 (38%), Positives = 374/703 (53%), Gaps = 36/703 (5%)

Query: 610  VESSIL-----DAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVE--MARAG 662
            VE+S+L     +A   VD+A N T++ +  +    S+  +    Y + P+     + RA 
Sbjct: 31   VETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAA 90

Query: 663  EIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRC 722
            +     L L+ E+++           F   D+++   L L++  SGC  R     CS+  
Sbjct: 91   DYMHVALGLLEEKLQPQ-----RSGPFNVTDVLTEPQLRLLSQASGCALRDQAERCSD-- 143

Query: 723  FHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQP--LPPP 780
               KYR   G CNN ++P  GA+  A AR L   Y DG+  P G   P   R    LP  
Sbjct: 144  ---KYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGW-TPSRRRNGFLLPLV 199

Query: 781  RLVATVWARAA--AVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTN 838
            R V+    R     +T D     M M WG F++HDLD +  + +   F+ G  C   C  
Sbjct: 200  RAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQ 259

Query: 839  DPPCFPMNTRHADPR-GTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGS 897
             PPCFP+     DPR      C+ F RS+P+C   +          R QIN  T+++D S
Sbjct: 260  LPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRV-------RNQINALTSFVDAS 312

Query: 898  NVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQES--PCFL 955
             VYGS    S  LR+ +   GLL     +  +G+ LLPF       C    + +  PCFL
Sbjct: 313  MVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFL 372

Query: 956  AGDHRANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYS 1015
            AGD R+ E   LAAMHTL+ REHNR+ATEL  LNP W G+ +Y EARKI+GA +Q ITY 
Sbjct: 373  AGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYR 432

Query: 1016 HWLPKVLGDPGTRMLRG-YRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATL-GE 1073
             +LP VLG    R   G YRGY  NV+  + N F T AFRFGHT++ P ++RL++     
Sbjct: 433  DFLPLVLGKARARRTLGHYRGYCSNVDPRVANVF-TLAFRFGHTMLQPFMFRLDSQYRAS 491

Query: 1074 ISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSA 1133
                H+P   A F+  RI+ EGGIDP+LRGL    AK      +L  EL  RLF      
Sbjct: 492  APNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRI 551

Query: 1134 AVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGD 1193
             +D AA  +QR RDHG+P Y  +R FC L+  +N   L   +K+ ++ +K   LYG+P +
Sbjct: 552  GLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDN 611

Query: 1194 IDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASL 1253
            ID+W   + E L+PG RVGP L CLF  QF+R RDGDRFW++  GVFT  Q   L + SL
Sbjct: 612  IDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSRISL 671

Query: 1254 SRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQ 1296
            SR++CDN   I  V  D+F    YP+ ++NCS IP+++L  W+
Sbjct: 672  SRIICDN-TGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWR 713


>gi|4557759 myeloperoxidase [Homo sapiens]
          Length = 745

 Score =  438 bits (1127), Expect = e-122
 Identities = 262/698 (37%), Positives = 370/698 (53%), Gaps = 26/698 (3%)

Query: 610  VESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMA--RAGEIFEH 667
            V SS+ +A Q VD A    R  +  +    S+  +    Y + P+       RA +    
Sbjct: 62   VLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHV 121

Query: 668  TLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKY 727
             L L+  +++      L  + F   D+++P  L++++  SGC  +     C  +    KY
Sbjct: 122  ALDLLERKLRS-----LWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQ---DKY 173

Query: 728  RAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQ-PLPPPRLVATV 786
            R   G CNN + PT GA+  AF R L   Y DG   P G    V     P+   R V+  
Sbjct: 174  RTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNE 233

Query: 787  WARAAA--VTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFP 844
              R     +TPD   + M M WG  L+HDLD T    + A F  G  C + C   PPCFP
Sbjct: 234  IVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFP 293

Query: 845  MNTRHADPR-GTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSS 903
            +     DPR    A C+ F RS PAC          ++  R QIN  T+++D S VYGS 
Sbjct: 294  LKIPPNDPRIKNQADCIPFFRSCPACPGS-------NITIRNQINALTSFVDASMVYGSE 346

Query: 904  ERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQES--PCFLAGDHRA 961
            E  ++ LR+ S   GLL     +  +G+ LLPF       C    + +  PCFLAGD R+
Sbjct: 347  EPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRS 406

Query: 962  NEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKV 1021
            +E   L +MHTL  REHNR+ATEL +LNP W+G  +YQEARKIVGA +Q ITY  +LP V
Sbjct: 407  SEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLV 466

Query: 1022 LGDPGTRM-LRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEG-HL 1079
            LG    R  L  YR YN +V+  I N F T AFR+GHTLI P ++RL+     +     +
Sbjct: 467  LGPTAMRKYLPTYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNRYQPMEPNPRV 525

Query: 1080 PFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAA 1139
            P  +  F+  R++ EGGIDP+LRGL    AK    + +   E+ +RLF       +D  A
Sbjct: 526  PLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPA 585

Query: 1140 TIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPA 1199
              +QR RDHG+P Y  +R FC L   +    L   +++ ++ +KL + YG+P +ID+W  
Sbjct: 586  LNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMG 645

Query: 1200 LMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCD 1259
             + E L    RVGP L C+  TQF++LRDGDRFW+EN GVF+  Q   L Q SL R++CD
Sbjct: 646  GVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICD 705

Query: 1260 NGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQD 1297
            N       + ++F+   YP+D++NCS +P ++L  W++
Sbjct: 706  NTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 743


>gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens]
          Length = 712

 Score =  398 bits (1022), Expect = e-110
 Identities = 250/646 (38%), Positives = 349/646 (54%), Gaps = 34/646 (5%)

Query: 660  RAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCS 719
            R G+++E +L+ +R++       D           +   SLSL     GC A  P+  C 
Sbjct: 86   RNGQVWEESLKRLRQKASLTNVTDPS---------LDLTSLSLEV---GCGAPAPVVRC- 132

Query: 720  NRCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQ--PL 777
            + C  + YR   G CNN ++P  GAA  A AR L   Y DG+  P G   P  +R   PL
Sbjct: 133  DPC--SPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGW-TPGKTRNGFPL 189

Query: 778  PPPRLVAT--VWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPA-LSTARFSDGRPCSS 834
            P  R V+   V         D + + + M WG  ++HDLD      L ++ +S  + C  
Sbjct: 190  PLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQ-CDE 248

Query: 835  VCTNDPPCFPMNTRHADPR-GTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAY 893
             C     CFP+     DP+ GT   CM F R+   C    P+    S+ AREQIN  T++
Sbjct: 249  YCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVC----PTPPYKSL-AREQINALTSF 303

Query: 894  IDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECA--RQEQES 951
            +D S VY S    +  LR+ S P GL+         G P LP+ +  P+ C         
Sbjct: 304  LDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTTARV 363

Query: 952  PCFLAGDHRANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQH 1011
            PCFLAGD RA+EH+ LA  HTL+ REHNR+A EL  LNP W+G  +YQEARKI+GA +Q 
Sbjct: 364  PCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQI 423

Query: 1012 ITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATL 1071
            IT+  +LP +LGD   + +  Y+GY+ +V+  I N F T AFRFGH  +   ++RL+   
Sbjct: 424  ITFRDYLPILLGDHMQKWIPPYQGYSESVDPRISNVF-TFAFRFGHLEVPSSMFRLDENY 482

Query: 1072 GEIS-EGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAA 1130
                 E  LP H   F+  R++K+GGIDP++RGL    +K    + +++ EL  +LF   
Sbjct: 483  QPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPT 542

Query: 1131 YSA-AVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYG 1189
            +     D AA   QR RDHG P Y  +R FC+L+  +  E+L   +K   + +KL  LYG
Sbjct: 543  HRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYG 602

Query: 1190 SPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLK 1249
            +P +ID+W   + E L+   RVGP L CL   QFQ++RDGDRFW+ENPGVFT  Q   L+
Sbjct: 603  TPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQ 662

Query: 1250 QASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVW 1295
            + S SR++CDN   I +V  D F    YP D+++CS I K+DL  W
Sbjct: 663  KMSFSRLVCDN-TRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPW 707


>gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens]
          Length = 629

 Score =  395 bits (1015), Expect = e-109
 Identities = 240/598 (40%), Positives = 330/598 (55%), Gaps = 22/598 (3%)

Query: 708  GCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGL 767
            GC A  P+  C + C  + YR   G CNN ++P  GAA  A AR L   Y DG+  P G 
Sbjct: 39   GCGAPAPVVRC-DPC--SPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGW 95

Query: 768  GLPVGSRQ--PLPPPRLVAT--VWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPA-LS 822
              P  +R   PLP  R V+   V         D + + + M WG  ++HDLD      L 
Sbjct: 96   -TPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELG 154

Query: 823  TARFSDGRPCSSVCTNDPPCFPMNTRHADPR-GTHAPCMLFARSSPACASGRPSATVDSV 881
            ++ +S  + C   C     CFP+     DP+ GT   CM F R+   C    P+    S+
Sbjct: 155  SSEYSKAQ-CDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVC----PTPPYKSL 209

Query: 882  YAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPP 941
             AREQIN  T+++D S VY S    +  LR+ S P GL+         G P LP+ +  P
Sbjct: 210  -AREQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKP 268

Query: 942  TECA--RQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQ 999
            + C         PCFLAGD RA+EH+ LA  HTL+ REHNR+A EL  LNP W+G  +YQ
Sbjct: 269  SPCEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQ 328

Query: 1000 EARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTL 1059
            EARKI+GA +Q IT+  +LP +LGD   + +  Y+GY+ +V+  I N F T AFRFGH  
Sbjct: 329  EARKILGAFVQIITFRDYLPILLGDHMQKWIPPYQGYSESVDPRISNVF-TFAFRFGHLE 387

Query: 1060 INPILYRLNATLGEIS-EGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLL 1118
            +   ++RL+        E  LP H   F+  R++K+GGIDP++RGL    +K    + ++
Sbjct: 388  VPSSMFRLDENYQPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMM 447

Query: 1119 SPELTQRLFSAAYSA-AVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKD 1177
            + EL  +LF   +     D AA   QR RDHG P Y  +R FC+L+  +  E+L   +K 
Sbjct: 448  TGELRNKLFQPTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKS 507

Query: 1178 SEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENP 1237
              + +KL  LYG+P +ID+W   + E L+   RVGP L CL   QFQ++RDGDRFW+ENP
Sbjct: 508  KMLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENP 567

Query: 1238 GVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVW 1295
            GVFT  Q   L++ S SR++CDN   I +V  D F    YP D+++CS I K+DL  W
Sbjct: 568  GVFTNEQKDSLQKMSFSRLVCDN-TRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPW 624


>gi|28558984 thyroid peroxidase isoform b [Homo sapiens]
          Length = 876

 Score =  393 bits (1009), Expect = e-109
 Identities = 250/701 (35%), Positives = 353/701 (50%), Gaps = 78/701 (11%)

Query: 612  SSILDAVQR-VDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQ 670
            SS+L+  +R VD+A+ +T +    ++   S   L  F    +P    +ARA EI E ++Q
Sbjct: 40   SSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQ 99

Query: 671  LIRERVKQGLTVDLEGKEFRY-NDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRA 729
             ++ +V      +L+ ++ ++  D +S   LS+IAN+SGC      P C N C   KYR 
Sbjct: 100  AMKRKV------NLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRP 153

Query: 730  HDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLP-VGSRQPLPPPRLVA--TV 786
              G CNN   P WGA+ TA AR L P Y DG   PRG     + +  PLPP R V    +
Sbjct: 154  ITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVI 213

Query: 787  WARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMN 846
                  VT D  Y+ +LM WG +++HD+  T  + S A F  G  C   C N  PCFP+ 
Sbjct: 214  QVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQ 273

Query: 847  TRHADPRGTHAPCMLFARSSPACASGRPSA---TVDSVYAREQINQQTAYIDGSNVYGSS 903
                        C+ F RSS AC +G   A    + +   R+Q+N  T+++D S VYGSS
Sbjct: 274  LPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSS 333

Query: 904  ERESQALRDPSVPRGLLKTGFPWPPSGKPLLPF-STGPPTECARQ-----EQESPCFLAG 957
                + LR+ +   GLL+       SG+  LPF     P  CA +     E   PCFLAG
Sbjct: 334  PALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAG 393

Query: 958  DHRANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHW 1017
            D RA+E  +L A+HTLW REHNR+A  L ALN HW  + VYQEARK+VGA  Q IT   +
Sbjct: 394  DGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDY 453

Query: 1018 LPKVLGDPGTRMLRG-YRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISE 1076
            +P++LG    +   G Y GY+   N  + N F+TAAFRFGH  I+P++ RL+A+  E   
Sbjct: 454  IPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQE--- 510

Query: 1077 GHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVD 1136
                                  P L GL+                L Q  FS        
Sbjct: 511  ---------------------HPDLPGLW----------------LHQAFFSPW------ 527

Query: 1137 SAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDL 1196
               T+++ G       Y ++R FC L  ++   DL   I    +  K+  LY  P +ID+
Sbjct: 528  ---TLLRGG-------YNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDNIDV 577

Query: 1197 WPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRV 1256
            W   + E+ +P  R GP   CL   Q + LRDGD FW+EN  VFT AQ  +L++ SLSRV
Sbjct: 578  WLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSLSRV 637

Query: 1257 LCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQD 1297
            +CDN   + +V  D F   ++P+D+ +C  I  ++L  W++
Sbjct: 638  ICDN-TGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRE 677


>gi|28558990 thyroid peroxidase isoform e [Homo sapiens]
          Length = 760

 Score =  224 bits (571), Expect = 5e-58
 Identities = 116/293 (39%), Positives = 176/293 (60%), Gaps = 7/293 (2%)

Query: 1009 LQHITYSHWLPKVLGDPGTRMLRG-YRGYNPNVNAGIINSFATAAFRFGHTLINPILYRL 1067
            +Q IT   ++P++LG    +   G Y GY+   N  + N F+TAAFRFGH  I+P++ RL
Sbjct: 272  IQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRL 331

Query: 1068 NATLGEISEGHLP---FHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQ 1124
            +A+  E  +  LP    H+A FSP  +++ GG+DP++RGL    AK +    L++ ELT+
Sbjct: 332  DASFQEHPD--LPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTE 389

Query: 1125 RLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKL 1184
            RLF  + S+ +D A+  +QRGRDHG+P Y ++R FC L  ++   DL   I    +  K+
Sbjct: 390  RLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKI 449

Query: 1185 RKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQ 1244
              LY  P +ID+W   + E+ +P  R GP   CL   Q + LRDGD FW+EN  VFT AQ
Sbjct: 450  LDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQ 509

Query: 1245 LTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQD 1297
              +L++ SLSRV+CDN   + +V  D F   ++P+D+ +C  I  ++L  W++
Sbjct: 510  RRELEKHSLSRVICDN-TGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRE 561



 Score =  138 bits (348), Expect = 3e-32
 Identities = 86/239 (35%), Positives = 123/239 (51%), Gaps = 11/239 (4%)

Query: 612 SSILDAVQR-VDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQ 670
           SS+L+  +R VD+A+ +T +    ++   S   L  F    +P    +ARA EI E ++Q
Sbjct: 40  SSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQ 99

Query: 671 LIRERVKQGLTVDLEGKEFRY-NDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRA 729
            ++ +      V+L+ ++ ++  D +S   LS+IAN+SGC      P C N C   KYR 
Sbjct: 100 AMKRK------VNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRP 153

Query: 730 HDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLP-VGSRQPLPPPRLVA--TV 786
             G CNN   P WGA+ TA AR L P Y DG   PRG     + +  PLPP R V    +
Sbjct: 154 ITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVI 213

Query: 787 WARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPM 845
                 VT D  Y+ +LM WG +++HD+  T  + S A F  G  C   C N  PCFP+
Sbjct: 214 QVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPI 272


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score =  220 bits (560), Expect = 9e-57
 Identities = 152/489 (31%), Positives = 229/489 (46%), Gaps = 40/489 (8%)

Query: 50  QQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109
           Q+   L L FN +  +   +  +L +L+ L L++N I  I+  AF+GL +L  L L  NE
Sbjct: 307 QKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNE 366

Query: 110 IHALDKQT---FKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSF 166
           I    + T   F GL SL  L +  N+++ +    F  L  LE L L  N +  +   +F
Sbjct: 367 ISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAF 426

Query: 167 SNLDSLKRLRLDSNALVCDCDLMWL-----GELLQGFAQHGHTQAAATCEYPRRLHGRAV 221
             + +LK L + S++ +CDC L WL     G +LQ F         ATC +P  L G+++
Sbjct: 427 VKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFV-------TATCAHPESLKGQSI 479

Query: 222 ASVTVEEFNCQS---PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEII--WIHNNHSL-- 274
            SV  E F C     P+I  +P+      G  + FTC A  +    +   W  +N  L  
Sbjct: 480 FSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTN 539

Query: 275 -DLEDDTRLNVFDDGTLM-------IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSL 326
            D+E+   ++   DG +M       +R      +G YQC+  N  G   +  A L  + L
Sbjct: 540 ADMENFVHVHA-QDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL 598

Query: 327 PAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSR----HVATSSG 382
           P   SF   P D  +   T   LEC ATGHP+P I W +D G +   +R    HV     
Sbjct: 599 P---SFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDD 655

Query: 383 LY-LQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCE 441
           ++ + ++   D G ++C A NS G++ A A + V   P   V  +D+VV     V   C+
Sbjct: 656 VFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCK 715

Query: 442 ADGNPPPVIVWTKTGGQLPV-EGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVS 500
           A GNPPP I W K    L + E  H    +  L +      D G+Y C+  ++LG ++  
Sbjct: 716 ATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAH 775

Query: 501 VQLTVKPKA 509
            QL+V P A
Sbjct: 776 SQLSVLPAA 784



 Score =  106 bits (265), Expect = 1e-22
 Identities = 82/294 (27%), Positives = 117/294 (39%), Gaps = 22/294 (7%)

Query: 329 KPSFVIQPQDTEVLIGTSTTLECMATGHPHPLIT--WTRDNGL----ELDGSRHVATSSG 382
           KP  + QP+ T  ++G      C A       +T  W +DN +    +++   HV    G
Sbjct: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553

Query: 383 --------LYLQNITQRDHGRFTCHANNSHG-TVQAAANIIVQAPPQFTVTPKDQVVLEE 433
                   L+L+ +T    GR+ C   N  G T    A + V   P FT TP D  +   
Sbjct: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTT 613

Query: 434 HAVEWLCEADGNPPPVIVWTKTGG-QLPVEGQ---HTVLSSGTLRIDRAAQHDQGQYECQ 489
                 C A G+P P I W K GG   P   +   H +       I      D G Y C 
Sbjct: 614 TMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCT 673

Query: 490 AVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGV 549
           A +S G    +  LTV      V     +D  V VG+ + + C A G P P ITW K   
Sbjct: 674 AQNSAGSISANATLTVLETPSLVVPL--EDRVVSVGETVALQCKATGNPPPRITWFKGDR 731

Query: 550 QITESGKFHV-DDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQG 602
            ++ + + H+  D   L + +    D GRY C   N+ G    +  L+V    G
Sbjct: 732 PLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAG 785



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 47/151 (31%), Positives = 76/151 (50%), Gaps = 6/151 (3%)

Query: 38  MHLMLDHIPQVPQQT------TVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISR 91
           + L  + I Q+P +       T LDL  NRIR I G  F+ L +L  L L  N+I K++ 
Sbjct: 193 LRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTD 252

Query: 92  NAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERL 151
            AF GL  +  L+L  N +  ++  +  GL +L  L++  N +  +  + +    +L  L
Sbjct: 253 GAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHEL 312

Query: 152 FLHNNKLSKIPAGSFSNLDSLKRLRLDSNAL 182
            L  N L+++   S + L SL  LRL  N++
Sbjct: 313 VLSFNNLTRLDEESLAELSSLSVLRLSHNSI 343



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 46/165 (27%), Positives = 81/165 (49%), Gaps = 3/165 (1%)

Query: 20  PGLPCPSRCLCFKSTVRCMHLMLDHIP-QVPQQTTVLDLRFNRIREIPGSAFKKLKNLNT 78
           P  PC + C C   ++ C    L  +P  +P  T  L+L +N++ EI  + F+ L NL  
Sbjct: 37  PRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQE 96

Query: 79  LLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQ 138
           + LNNN +  +  +      +++ L+L  N+I +++    K  +SLE L +  N +  ++
Sbjct: 97  VYLNNNELTAVP-SLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVR 155

Query: 139 PETFGDLLRLERLFLHNNKLSKIPAGSFSNLD-SLKRLRLDSNAL 182
              F     ++ L L  N++  +  G+F  L  SL  LRL  N +
Sbjct: 156 NTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRI 200



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 48/131 (36%), Positives = 68/131 (51%), Gaps = 2/131 (1%)

Query: 54  VLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLE-NLLYLYLYKNEIHA 112
           VLDL  N I E+  + F     +  L L  N I  +   AF+GL  +LL L L KN I  
Sbjct: 143 VLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQ 202

Query: 113 LDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSL 172
           L  + FK L  L  L ++ N++ +++  TF  L  LE L L  N +SK+  G+F  L  +
Sbjct: 203 LPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKM 261

Query: 173 KRLRLDSNALV 183
             L L+ N+LV
Sbjct: 262 HVLHLEYNSLV 272


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score =  212 bits (539), Expect = 2e-54
 Identities = 144/481 (29%), Positives = 234/481 (48%), Gaps = 28/481 (5%)

Query: 50  QQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109
           Q+ + LDL FN +  +  S+F  L  LNTL + NN +  I+  AF GL +L  L L  NE
Sbjct: 311 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 370

Query: 110 IHALDKQ---TFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSF 166
           I    +     F GL  L  L +  N++  +  + F  L  LE L L +N +  +   +F
Sbjct: 371 ISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF 430

Query: 167 SNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTV 226
           S +  L++L L++++L+CDC L WL + +     +  +   A+C +P+ L GR++ +V+ 
Sbjct: 431 SQMKKLQQLHLNTSSLLCDCQLKWLPQWVA--ENNFQSFVNASCAHPQLLKGRSIFAVSP 488

Query: 227 EEFNCQ---SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEI--IWIHNN---HSLDLED 278
           + F C     P+IT +P+      G+ + F C A  +    +   W  +N   H  ++E+
Sbjct: 489 DGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMEN 548

Query: 279 DTRL-----NVFDDGTLM-IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSF 332
              L      V +  T++ +R    + +G YQC+  N  G + +  A L  + L   PSF
Sbjct: 549 YAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML---PSF 605

Query: 333 VIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSR----HVATSSGL-YLQN 387
              P D  +  G    LEC A GHP P I W +D G +   +R    HV     + ++ +
Sbjct: 606 TKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVD 665

Query: 388 ITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPP 447
           +   D G ++C A NS G++ A A + V   P F     D+ V +       C A G+PP
Sbjct: 666 VKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPP 725

Query: 448 PVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ-HDQGQYECQAVSSLGVKKVSVQLTVK 506
           P + WTK    L V  +H   +   L I   +   D G+Y C+  ++LG ++ +V+L+V 
Sbjct: 726 PKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVI 785

Query: 507 P 507
           P
Sbjct: 786 P 786



 Score =  128 bits (321), Expect = 5e-29
 Identities = 143/600 (23%), Positives = 230/600 (38%), Gaps = 92/600 (15%)

Query: 55  LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114
           L+L  N+I+ + G  F+ L  L +L +  N + K+   AF GL N+  L L  N +  + 
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279

Query: 115 KQTFKGLISLEHLYIHFNQLEMLQPE-------------TFGDLLRLE-----------R 150
           K    GL+ L+ L++  N +  + P+             TF  L RL+            
Sbjct: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 339

Query: 151 LFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATC 210
           L + NN++S I   +F  L SLK L L +N      ++ W  E + G        A +  
Sbjct: 340 LHIGNNRVSYIADCAFRGLSSLKTLDLKNN------EISWTIEDMNG--------AFSGL 385

Query: 211 EYPRRL--HGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWI 268
           +  RRL   G  + S+T + F         +  D  + S          +GN   ++  +
Sbjct: 386 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMS---------LQGNAFSQMKKL 436

Query: 269 HNNH--SLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSL 326
              H  +  L  D +L                 +  +Q     S    +       ++  
Sbjct: 437 QQLHLNTSSLLCDCQLKWLPQWVA---------ENNFQSFVNASCAHPQLLKGRSIFAVS 487

Query: 327 P--------AKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLIT--WTRDNGL----ELD 372
           P         KP   +QP+    + G++ +  C A       +T  W +DN L    E++
Sbjct: 488 PDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEME 547

Query: 373 GSRHVATSSG--------LYLQNITQRDHGRFTCHANNSHGTVQAA-ANIIVQAPPQFTV 423
              H+    G        L L+ +     G++ C  +N  G+  +  A + V   P FT 
Sbjct: 548 NYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTK 607

Query: 424 TPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGG-QLPVEGQ---HTVLSSGTLRIDRAA 479
           TP D  +         C A G+P P I W K GG   P   +   H +       I    
Sbjct: 608 TPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVK 667

Query: 480 QHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQ 539
             D G Y C A +S G   +S   T+       F +   D +V  G+   + C A G P 
Sbjct: 668 IEDIGVYSCTAQNSAG--SISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPP 725

Query: 540 PIITWNKEG--VQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
           P + W K+   + +TE   F   ++  L I D+   D G+Y C   N+ G    N+ L+V
Sbjct: 726 PKLNWTKDDSPLVVTERHFFAAGNQ-LLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 784



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 97/414 (23%), Positives = 162/414 (39%), Gaps = 65/414 (15%)

Query: 55  LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114
           L L+ NRIR I   AF  L  L  L L++N I  +  NAF  ++ L  L+L  + +    
Sbjct: 391 LILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDC 450

Query: 115 KQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLF---------------------- 152
           +  +      E+ +  F       P+    LL+   +F                      
Sbjct: 451 QLKWLPQWVAENNFQSFVNASCAHPQ----LLKGRSIFAVSPDGFVCDDFPKPQITVQPE 506

Query: 153 ----LHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAA 208
               +  + LS I + + S+   +       N L+ D ++       + +A H   Q   
Sbjct: 507 TQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEM-------ENYA-HLRAQGGE 558

Query: 209 TCEYPRRLHGRAVASVTVEEFNC-------------------QSPRITFEPQDVEVPSGN 249
             EY   L  R V   +  ++ C                     P  T  P D+ + +G 
Sbjct: 559 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 618

Query: 250 TVYFTCRAEGNPKPEIIWIHNNHS-LDLEDDTRLNVF-DDGTLMIRNTRESDQGVYQCMA 307
                C A G+P P+I W  +  +      + R++V  +D    I + +  D GVY C A
Sbjct: 619 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 678

Query: 308 RNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDN 367
           +NSAG     + +    ++   PSF+    D  V  G +  L+C+A G P P + WT+D+
Sbjct: 679 QNSAGSISANATL----TVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDD 734

Query: 368 GLELDGSRH--VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPP 419
              +   RH   A +  L + +    D G++TC  +N+ GT +    + V   P
Sbjct: 735 SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 788



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 51/162 (31%), Positives = 81/162 (50%), Gaps = 5/162 (3%)

Query: 23  PCPSRCLCFKSTVRCMHLMLDHIPQ-VPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLL 81
           PCP+ C C    + C    L  +P+ +P     LDL  NR+  I  S+   L++L  + L
Sbjct: 46  PCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKL 105

Query: 82  NNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPET 141
           NNN +  I  N      N+  L L  N I  +  +  K   SLE L +  N +  LQ  T
Sbjct: 106 NNNELETIP-NLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ--T 162

Query: 142 FGDLLRLERLFLHNNKLSKIPAGSFSNL-DSLKRLRLDSNAL 182
               L+L+ L+L++N+++ +  G F NL ++L  L+L+ N +
Sbjct: 163 AFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRI 204


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score =  212 bits (539), Expect = 2e-54
 Identities = 144/481 (29%), Positives = 234/481 (48%), Gaps = 28/481 (5%)

Query: 50  QQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109
           Q+ + LDL FN +  +  S+F  L  LNTL + NN +  I+  AF GL +L  L L  NE
Sbjct: 251 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 310

Query: 110 IHALDKQ---TFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSF 166
           I    +     F GL  L  L +  N++  +  + F  L  LE L L +N +  +   +F
Sbjct: 311 ISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF 370

Query: 167 SNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTV 226
           S +  L++L L++++L+CDC L WL + +     +  +   A+C +P+ L GR++ +V+ 
Sbjct: 371 SQMKKLQQLHLNTSSLLCDCQLKWLPQWVA--ENNFQSFVNASCAHPQLLKGRSIFAVSP 428

Query: 227 EEFNCQ---SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEI--IWIHNN---HSLDLED 278
           + F C     P+IT +P+      G+ + F C A  +    +   W  +N   H  ++E+
Sbjct: 429 DGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMEN 488

Query: 279 DTRL-----NVFDDGTLM-IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSF 332
              L      V +  T++ +R    + +G YQC+  N  G + +  A L  + L   PSF
Sbjct: 489 YAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML---PSF 545

Query: 333 VIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSR----HVATSSGL-YLQN 387
              P D  +  G    LEC A GHP P I W +D G +   +R    HV     + ++ +
Sbjct: 546 TKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVD 605

Query: 388 ITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPP 447
           +   D G ++C A NS G++ A A + V   P F     D+ V +       C A G+PP
Sbjct: 606 VKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPP 665

Query: 448 PVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ-HDQGQYECQAVSSLGVKKVSVQLTVK 506
           P + WTK    L V  +H   +   L I   +   D G+Y C+  ++LG ++ +V+L+V 
Sbjct: 666 PKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVI 725

Query: 507 P 507
           P
Sbjct: 726 P 726



 Score =  128 bits (321), Expect = 5e-29
 Identities = 143/600 (23%), Positives = 230/600 (38%), Gaps = 92/600 (15%)

Query: 55  LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114
           L+L  N+I+ + G  F+ L  L +L +  N + K+   AF GL N+  L L  N +  + 
Sbjct: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219

Query: 115 KQTFKGLISLEHLYIHFNQLEMLQPE-------------TFGDLLRLE-----------R 150
           K    GL+ L+ L++  N +  + P+             TF  L RL+            
Sbjct: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 279

Query: 151 LFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATC 210
           L + NN++S I   +F  L SLK L L +N      ++ W  E + G        A +  
Sbjct: 280 LHIGNNRVSYIADCAFRGLSSLKTLDLKNN------EISWTIEDMNG--------AFSGL 325

Query: 211 EYPRRL--HGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWI 268
           +  RRL   G  + S+T + F         +  D  + S          +GN   ++  +
Sbjct: 326 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMS---------LQGNAFSQMKKL 376

Query: 269 HNNH--SLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSL 326
              H  +  L  D +L                 +  +Q     S    +       ++  
Sbjct: 377 QQLHLNTSSLLCDCQLKWLPQWVA---------ENNFQSFVNASCAHPQLLKGRSIFAVS 427

Query: 327 P--------AKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLIT--WTRDNGL----ELD 372
           P         KP   +QP+    + G++ +  C A       +T  W +DN L    E++
Sbjct: 428 PDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEME 487

Query: 373 GSRHVATSSG--------LYLQNITQRDHGRFTCHANNSHGTVQAA-ANIIVQAPPQFTV 423
              H+    G        L L+ +     G++ C  +N  G+  +  A + V   P FT 
Sbjct: 488 NYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTK 547

Query: 424 TPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGG-QLPVEGQ---HTVLSSGTLRIDRAA 479
           TP D  +         C A G+P P I W K GG   P   +   H +       I    
Sbjct: 548 TPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVK 607

Query: 480 QHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQ 539
             D G Y C A +S G   +S   T+       F +   D +V  G+   + C A G P 
Sbjct: 608 IEDIGVYSCTAQNSAG--SISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPP 665

Query: 540 PIITWNKEG--VQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
           P + W K+   + +TE   F   ++  L I D+   D G+Y C   N+ G    N+ L+V
Sbjct: 666 PKLNWTKDDSPLVVTERHFFAAGNQ-LLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 97/414 (23%), Positives = 162/414 (39%), Gaps = 65/414 (15%)

Query: 55  LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114
           L L+ NRIR I   AF  L  L  L L++N I  +  NAF  ++ L  L+L  + +    
Sbjct: 331 LILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDC 390

Query: 115 KQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLF---------------------- 152
           +  +      E+ +  F       P+    LL+   +F                      
Sbjct: 391 QLKWLPQWVAENNFQSFVNASCAHPQ----LLKGRSIFAVSPDGFVCDDFPKPQITVQPE 446

Query: 153 ----LHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAA 208
               +  + LS I + + S+   +       N L+ D ++       + +A H   Q   
Sbjct: 447 TQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEM-------ENYA-HLRAQGGE 498

Query: 209 TCEYPRRLHGRAVASVTVEEFNC-------------------QSPRITFEPQDVEVPSGN 249
             EY   L  R V   +  ++ C                     P  T  P D+ + +G 
Sbjct: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558

Query: 250 TVYFTCRAEGNPKPEIIWIHNNHS-LDLEDDTRLNVF-DDGTLMIRNTRESDQGVYQCMA 307
                C A G+P P+I W  +  +      + R++V  +D    I + +  D GVY C A
Sbjct: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618

Query: 308 RNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDN 367
           +NSAG     + +    ++   PSF+    D  V  G +  L+C+A G P P + WT+D+
Sbjct: 619 QNSAGSISANATL----TVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDD 674

Query: 368 GLELDGSRH--VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPP 419
              +   RH   A +  L + +    D G++TC  +N+ GT +    + V   P
Sbjct: 675 SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 44/142 (30%), Positives = 79/142 (55%), Gaps = 4/142 (2%)

Query: 42  LDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLL 101
           + ++  V    T+L L  NRI EI     K+ ++L TL L++N+I ++ + AF  L+ L 
Sbjct: 53  IPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LK 110

Query: 102 YLYLYKNEIHALDKQTFKGLI-SLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSK 160
           YLYL  N + +++   F  L  +L  L ++ N++  + P+ F  L +L+ L L+ NK+  
Sbjct: 111 YLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKN 169

Query: 161 IPAGSFSNLDSLKRLRLDSNAL 182
           +   +F  L +LK L++  N +
Sbjct: 170 VDGLTFQGLGALKSLKMQRNGV 191



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 41/128 (32%), Positives = 66/128 (51%), Gaps = 4/128 (3%)

Query: 56  DLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDK 115
           DL  NR+  I  S+   L++L  + LNNN +  I  N      N+  L L  N I  +  
Sbjct: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEILP 78

Query: 116 QTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNL-DSLKR 174
           +  K   SLE L +  N +  LQ  T    L+L+ L+L++N+++ +  G F NL ++L  
Sbjct: 79  EHLKEFQSLETLDLSSNNISELQ--TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLV 136

Query: 175 LRLDSNAL 182
           L+L+ N +
Sbjct: 137 LKLNRNRI 144


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score =  199 bits (505), Expect = 2e-50
 Identities = 145/480 (30%), Positives = 230/480 (47%), Gaps = 31/480 (6%)

Query: 50  QQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109
           Q+ + LDL +N++  +  SAF  L  L  L L +N +  I+   F  L NL  L L  NE
Sbjct: 311 QRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNE 370

Query: 110 IH-ALD--KQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSF 166
           I  A++   + F GL SL  L +  NQ++ +  + F  L  LE L L+NN +  I   +F
Sbjct: 371 ISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF 430

Query: 167 SNLDSLKRLRLDSNALVCDCDLMWLGE-LLQGFAQHGHTQAAATCEYPRRLHGRAVASVT 225
           S    LK L L++++L+CDC L WL + L+    QH       +C +P  L G+++ +V 
Sbjct: 431 SQTH-LKELILNTSSLLCDCHLKWLLQWLVDNNFQHS---VNVSCAHPEWLAGQSILNVD 486

Query: 226 VEEFNCQS---PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEI--IWIHNNHSL-DLEDD 279
           +++F C     P+I   P+ +    G  V  TC A  +    +  +W  ++  L D++ +
Sbjct: 487 LKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTE 546

Query: 280 TRLNVFDDG--------TLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPS 331
             +  +            L + N   +D+G YQC+  N  G   +Q A L  + +P   S
Sbjct: 547 NFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMP---S 603

Query: 332 FVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSR----HVATSSGLY-LQ 386
           F+  P D  +  G    LEC A GHP P I+W +D G +   +R    HV     ++ + 
Sbjct: 604 FLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIA 663

Query: 387 NITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNP 446
           N+   D G ++C A N+ G + A A++ V   P F    +D+ V         C A G+P
Sbjct: 664 NVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSP 723

Query: 447 PPVIVWTKTGGQLPVEGQHTVLSSGTLR-IDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
            P + WTK  G L V  +H   ++  L  I  A   D G+Y C   ++LG ++  + L V
Sbjct: 724 APRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 78/289 (26%), Positives = 115/289 (39%), Gaps = 22/289 (7%)

Query: 329 KPSFVIQPQDTEVLIGTSTTLECMA-TGHPHPLIT-WTRDNGLELD------------GS 374
           KP     P+    L G + TL C A +    P+ T W +D+ +  D              
Sbjct: 497 KPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAG 556

Query: 375 RHVATSSGLYLQNITQRDHGRFTCHANNSHGT-VQAAANIIVQAPPQFTVTPKDQVVLEE 433
             +  +S L+L N+   D G++ C   N  G+     A + V   P F  TP D  +   
Sbjct: 557 EALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTG 616

Query: 434 HAVEWLCEADGNPPPVIVWTKTGG-QLPVEGQ---HTVLSSGTLRIDRAAQHDQGQYECQ 489
                 C A+G+P P I W K GG   P   +   H +       I      D G Y C 
Sbjct: 617 AMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCM 676

Query: 490 AVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKE-G 548
           A ++ G    +  LTV       F +  +D +V  G+   + C A G P P + W K+ G
Sbjct: 677 AQNTAGGLSANASLTVLETPS--FIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDG 734

Query: 549 VQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
             +     F       L I DAG  D G+Y C+  N+ G    +++L V
Sbjct: 735 PLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783



 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 60/202 (29%), Positives = 99/202 (49%), Gaps = 12/202 (5%)

Query: 222 ASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHS-LDLEDDT 280
           A +TV E     P     P D+ + +G      C AEG+P P+I W  +  +      + 
Sbjct: 594 AKLTVNEM----PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARER 649

Query: 281 RLNVF-DDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDT 339
           R++V  +D    I N +  D G+Y CMA+N+AG     +++    ++   PSF+   +D 
Sbjct: 650 RMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASL----TVLETPSFIRPLEDK 705

Query: 340 EVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRH--VATSSGLYLQNITQRDHGRFT 397
            V  G +  L+C+A G P P + WT+D+G  L   RH   A +  L + +    D G++T
Sbjct: 706 TVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYT 765

Query: 398 CHANNSHGTVQAAANIIVQAPP 419
           C  +N+ GT +    + V + P
Sbjct: 766 CIMSNTLGTERGHIYLNVISSP 787



 Score = 87.4 bits (215), Expect = 9e-17
 Identities = 132/568 (23%), Positives = 214/568 (37%), Gaps = 64/568 (11%)

Query: 51  QTTVLDLRFNRIREIPGSAFKKLKN-LNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109
           Q   L+L  NRI  +    F  L + L  + LN N +  I    F+ L +L +L L +N 
Sbjct: 168 QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNR 226

Query: 110 IHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNL 169
           I  ++  TF+GL SL  L +  N +  L+   F  L  +E L L +N L+++  G    L
Sbjct: 227 IKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGL 286

Query: 170 DSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTV-EE 228
             L++L +  NA+       W  E  Q  ++   +    T     RL   A   +++ E 
Sbjct: 287 RMLQQLYVSQNAIERISPDAW--EFCQRLSELDLSYNQLT-----RLDESAFVGLSLLER 339

Query: 229 FNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLN-VFDD 287
            N    R+T     V     N      R       EI W   + S      T L  +   
Sbjct: 340 LNLGDNRVTHIADGVFRFLSNLQTLDLRNN-----EISWAIEDASEAFAGLTSLTKLILQ 394

Query: 288 GTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTST 347
           G  +   T+++  G+          E+     +   + +  + +   Q    E+++ TS+
Sbjct: 395 GNQIKSITKKAFIGL----------ESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSS 444

Query: 348 TL-ECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGT 406
            L +C    H   L+ W  DN  +   +   A    L  Q+I   D   F C        
Sbjct: 445 LLCDC----HLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDF----- 495

Query: 407 VQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEA--DGNPPPVIVWTKTGGQL-PVEG 463
                       PQ    P+  + L    V   C A    + P   VW K    L  V+ 
Sbjct: 496 ----------LKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDT 545

Query: 464 QHTVLS----------SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVF 513
           ++ V            +  L +      D+G+Y+C   +  G    S +  +    +  F
Sbjct: 546 ENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFG-SNYSQKAKLTVNEMPSF 604

Query: 514 TQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEG---VQITESGKFHV-DDEGTLTIYD 569
            + P D ++  G    + C A+G P P I+W K+G          + HV  ++    I +
Sbjct: 605 LKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIAN 664

Query: 570 AGFPDQGRYECVARNSFGLAVTNMFLTV 597
               D G Y C+A+N+ G    N  LTV
Sbjct: 665 VKIEDMGIYSCMAQNTAGGLSANASLTV 692



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 47/158 (29%), Positives = 83/158 (52%), Gaps = 10/158 (6%)

Query: 33  STVRCMHLMLDHIPQVPQQTTV-------LDLRFNRIREIPGSAFKKLKNLNTLLLNNNH 85
           S +  + L+ + IP++  Q          LDL  N I EI  S+F +++ L  L L+NN 
Sbjct: 120 SNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNR 178

Query: 86  IRKISRNAFEGLEN-LLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGD 144
           I  +    F+ L + LL + L +N +  +  + FK L  L+ L +  N++++++  TF  
Sbjct: 179 ITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQG 237

Query: 145 LLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNAL 182
           L  L  L +  N +SK+  G+F  L++++ L L+ N L
Sbjct: 238 LDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNL 275


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  193 bits (490), Expect = 1e-48
 Identities = 126/373 (33%), Positives = 185/373 (49%), Gaps = 21/373 (5%)

Query: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
           P DV V  G      C+   G+P+P I W  +   LD + D R+ +   G LMI  TR+S
Sbjct: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKS 194

Query: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
           D G Y C+  N  GE +++ A L   ++  +PSFV +P +  V +  S   +C A G P 
Sbjct: 195 DAGKYVCVGTNMVGERESEVAEL---TVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251

Query: 359 PLITWTRDNGLELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
           P + W +D+G EL  SR+ +     L ++ +T  D G +TC A N  G  +A+A + VQ 
Sbjct: 252 PTVRWRKDDG-ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 310

Query: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EGQHTVLS 469
           PP F V P+DQVV     V + CEA GNP P I W + G Q  +          + +V  
Sbjct: 311 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 370

Query: 470 SGTLRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLT--VKPKALAVFTQLPQDTSVEVG 525
           +G L I    + D G Y CQ ++  G  + K  +++T  +  +   V  Q P + +V V 
Sbjct: 371 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 430

Query: 526 KNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGRYECVARN 584
               +SC A G P P I W K+GV + T+  +    + G L I  A   D GRY C+A  
Sbjct: 431 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 490

Query: 585 SFGLAVTNMFLTV 597
             G A  + ++ V
Sbjct: 491 PSGEATWSAYIEV 503



 Score =  185 bits (469), Expect = 3e-46
 Identities = 123/386 (31%), Positives = 179/386 (46%), Gaps = 24/386 (6%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290
           PRI   P D+ V  G      C+AEG P P I W      ++ + DD R +  +   G+L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
               I + R+S  D+GVY C+ARN  GEA + +A L  + L  +  F   P D  V +G 
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL--RDDFRQNPSDVMVAVGE 146

Query: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR-DHGRFTCHANNS 403
              +EC    GHP P I+W +D     D    +    G  +   T++ D G++ C   N 
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206

Query: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
            G  ++  A + V   P F   P +  V  + + E+ CEA G+P P + W K  G+LP +
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-K 265

Query: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV 522
            ++ +    TL+I +    D G Y C A + +G  + S  LTV+      F   P+D  V
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP--PHFVVKPRDQVV 323

Query: 523 EVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFPD 574
            +G+ +   C A G PQP I W +EG Q           S +F V   G LTI +    D
Sbjct: 324 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 383

Query: 575 QGRYECVARNSFGLAVTNMFLTVTAI 600
            G Y C   N  G  +T  +L VT +
Sbjct: 384 VGYYICQTLNVAGSIITKAYLEVTDV 409



 Score =  128 bits (321), Expect = 5e-29
 Identities = 91/318 (28%), Positives = 142/318 (44%), Gaps = 27/318 (8%)

Query: 221 VASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDT 280
           VA +TV E     P     P ++ V   ++  F C A G+P P + W  ++  L     +
Sbjct: 214 VAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKS 266

Query: 281 RLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE 340
           R  + DD TL IR     D G Y C+A N  G+A+  + +    ++   P FV++P+D  
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL----TVQEPPHFVVKPRDQV 322

Query: 341 VLIGTSTTLECMATGHPHPLITWTRDNGLEL--------DGSRHVATSSG-LYLQNITQR 391
           V +G + T +C ATG+P P I W R+    L          SR   + +G L + N+ + 
Sbjct: 323 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 382

Query: 392 DHGRFTCHANNSHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGN 445
           D G + C   N  G++   A + V      + PP     P +Q V  +      C A G+
Sbjct: 383 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 442

Query: 446 PPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLT 504
           P P I+W K G  +  +      L +G L+I  A   D G+Y C A +  G    S  + 
Sbjct: 443 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 502

Query: 505 VKPKALAVFTQLPQDTSV 522
           V+   + V    P D ++
Sbjct: 503 VQEFGVPVQPPRPTDPNL 520



 Score = 90.9 bits (224), Expect = 8e-18
 Identities = 68/207 (32%), Positives = 95/207 (45%), Gaps = 14/207 (6%)

Query: 220 AVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL--- 276
           A A++TV+E     P    +P+D  V  G TV F C A GNP+P I W        L   
Sbjct: 302 ASATLTVQE----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357

Query: 277 ---EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFV 333
              +  +R +V   G L I N + SD G Y C   N AG   T++ +     +  +P  V
Sbjct: 358 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417

Query: 334 IQ--PQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL-ELDGSRHVATSSG-LYLQNIT 389
           I+  P +  V +  +  L C+ATG P P I W +D  L     SR     +G L ++   
Sbjct: 418 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477

Query: 390 QRDHGRFTCHANNSHGTVQAAANIIVQ 416
             D GR+TC A+   G    +A I VQ
Sbjct: 478 LGDTGRYTCIASTPSGEATWSAYIEVQ 504



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 13/182 (7%)

Query: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE-----GQHTVLSSGT 472
           PP+    P D +V +       C+A+G P P I W K G ++  +         +L SG+
Sbjct: 28  PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87

Query: 473 ---LRI--DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALA-VFTQLPQDTSVEVGK 526
              LRI   R ++ D+G Y C A + LG + VS   +++   L   F Q P D  V VG+
Sbjct: 88  LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 527 NINISCH-AQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + C   +G P+P I+W K+G  + +  +      G L I      D G+Y CV  N 
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206

Query: 586 FG 587
            G
Sbjct: 207 VG 208


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  193 bits (490), Expect = 1e-48
 Identities = 126/373 (33%), Positives = 185/373 (49%), Gaps = 21/373 (5%)

Query: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
           P DV V  G      C+   G+P+P I W  +   LD + D R+ +   G LMI  TR+S
Sbjct: 176 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKS 233

Query: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
           D G Y C+  N  GE +++ A L   ++  +PSFV +P +  V +  S   +C A G P 
Sbjct: 234 DAGKYVCVGTNMVGERESEVAEL---TVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 290

Query: 359 PLITWTRDNGLELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
           P + W +D+G EL  SR+ +     L ++ +T  D G +TC A N  G  +A+A + VQ 
Sbjct: 291 PTVRWRKDDG-ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 349

Query: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EGQHTVLS 469
           PP F V P+DQVV     V + CEA GNP P I W + G Q  +          + +V  
Sbjct: 350 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 409

Query: 470 SGTLRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLT--VKPKALAVFTQLPQDTSVEVG 525
           +G L I    + D G Y CQ ++  G  + K  +++T  +  +   V  Q P + +V V 
Sbjct: 410 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 469

Query: 526 KNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGRYECVARN 584
               +SC A G P P I W K+GV + T+  +    + G L I  A   D GRY C+A  
Sbjct: 470 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 529

Query: 585 SFGLAVTNMFLTV 597
             G A  + ++ V
Sbjct: 530 PSGEATWSAYIEV 542



 Score =  185 bits (469), Expect = 3e-46
 Identities = 123/386 (31%), Positives = 179/386 (46%), Gaps = 24/386 (6%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290
           PRI   P D+ V  G      C+AEG P P I W      ++ + DD R +  +   G+L
Sbjct: 68  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127

Query: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
               I + R+S  D+GVY C+ARN  GEA + +A L  + L  +  F   P D  V +G 
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL--RDDFRQNPSDVMVAVGE 185

Query: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR-DHGRFTCHANNS 403
              +EC    GHP P I+W +D     D    +    G  +   T++ D G++ C   N 
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 245

Query: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
            G  ++  A + V   P F   P +  V  + + E+ CEA G+P P + W K  G+LP +
Sbjct: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-K 304

Query: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV 522
            ++ +    TL+I +    D G Y C A + +G  + S  LTV+      F   P+D  V
Sbjct: 305 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP--PHFVVKPRDQVV 362

Query: 523 EVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFPD 574
            +G+ +   C A G PQP I W +EG Q           S +F V   G LTI +    D
Sbjct: 363 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 422

Query: 575 QGRYECVARNSFGLAVTNMFLTVTAI 600
            G Y C   N  G  +T  +L VT +
Sbjct: 423 VGYYICQTLNVAGSIITKAYLEVTDV 448



 Score =  128 bits (321), Expect = 5e-29
 Identities = 91/318 (28%), Positives = 142/318 (44%), Gaps = 27/318 (8%)

Query: 221 VASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDT 280
           VA +TV E     P     P ++ V   ++  F C A G+P P + W  ++  L     +
Sbjct: 253 VAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKS 305

Query: 281 RLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE 340
           R  + DD TL IR     D G Y C+A N  G+A+  + +    ++   P FV++P+D  
Sbjct: 306 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL----TVQEPPHFVVKPRDQV 361

Query: 341 VLIGTSTTLECMATGHPHPLITWTRDNGLEL--------DGSRHVATSSG-LYLQNITQR 391
           V +G + T +C ATG+P P I W R+    L          SR   + +G L + N+ + 
Sbjct: 362 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 421

Query: 392 DHGRFTCHANNSHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGN 445
           D G + C   N  G++   A + V      + PP     P +Q V  +      C A G+
Sbjct: 422 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 481

Query: 446 PPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLT 504
           P P I+W K G  +  +      L +G L+I  A   D G+Y C A +  G    S  + 
Sbjct: 482 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 541

Query: 505 VKPKALAVFTQLPQDTSV 522
           V+   + V    P D ++
Sbjct: 542 VQEFGVPVQPPRPTDPNL 559



 Score = 90.9 bits (224), Expect = 8e-18
 Identities = 68/207 (32%), Positives = 95/207 (45%), Gaps = 14/207 (6%)

Query: 220 AVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL--- 276
           A A++TV+E     P    +P+D  V  G TV F C A GNP+P I W        L   
Sbjct: 341 ASATLTVQE----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 396

Query: 277 ---EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFV 333
              +  +R +V   G L I N + SD G Y C   N AG   T++ +     +  +P  V
Sbjct: 397 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 456

Query: 334 IQ--PQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL-ELDGSRHVATSSG-LYLQNIT 389
           I+  P +  V +  +  L C+ATG P P I W +D  L     SR     +G L ++   
Sbjct: 457 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 516

Query: 390 QRDHGRFTCHANNSHGTVQAAANIIVQ 416
             D GR+TC A+   G    +A I VQ
Sbjct: 517 LGDTGRYTCIASTPSGEATWSAYIEVQ 543



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 61/210 (29%), Positives = 95/210 (45%), Gaps = 15/210 (7%)

Query: 392 DHGRFTCHANNSHGTVQAAANIIVQA--PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPV 449
           DHG     ++N   ++    + + Q   PP+    P D +V +       C+A+G P P 
Sbjct: 39  DHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT 98

Query: 450 IVWTKTGGQLPVE-----GQHTVLSSGT---LRI--DRAAQHDQGQYECQAVSSLGVKKV 499
           I W K G ++  +         +L SG+   LRI   R ++ D+G Y C A + LG + V
Sbjct: 99  IEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG-EAV 157

Query: 500 SVQLTVKPKALA-VFTQLPQDTSVEVGKNINISCH-AQGEPQPIITWNKEGVQITESGKF 557
           S   +++   L   F Q P D  V VG+   + C   +G P+P I+W K+G  + +  + 
Sbjct: 158 SHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER 217

Query: 558 HVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
                G L I      D G+Y CV  N  G
Sbjct: 218 ITIRGGKLMITYTRKSDAGKYVCVGTNMVG 247


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  188 bits (477), Expect = 4e-47
 Identities = 126/376 (33%), Positives = 185/376 (49%), Gaps = 24/376 (6%)

Query: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
           P DV V  G      C+   G+P+P I W  +   LD + D R+ +   G LMI  TR+S
Sbjct: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKS 194

Query: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
           D G Y C+  N  GE +++ A L   ++  +PSFV +P +  V +  S   +C A G P 
Sbjct: 195 DAGKYVCVGTNMVGERESEVAEL---TVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251

Query: 359 PLITWTRDNGLELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
           P + W +D+G EL  SR+ +     L ++ +T  D G +TC A N  G  +A+A + VQ 
Sbjct: 252 PTVRWRKDDG-ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310

Query: 418 ---PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EGQHT 466
              PP F V P+DQVV     V + CEA GNP P I W + G Q  +          + +
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370

Query: 467 VLSSGTLRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLT--VKPKALAVFTQLPQDTSV 522
           V  +G L I    + D G Y CQ ++  G  + K  +++T  +  +   V  Q P + +V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430

Query: 523 EVGKNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGRYECV 581
            V     +SC A G P P I W K+GV + T+  +    + G L I  A   D GRY C+
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 490

Query: 582 ARNSFGLAVTNMFLTV 597
           A    G A  + ++ V
Sbjct: 491 ASTPSGEATWSAYIEV 506



 Score =  184 bits (467), Expect = 5e-46
 Identities = 123/387 (31%), Positives = 180/387 (46%), Gaps = 23/387 (5%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290
           PRI   P D+ V  G      C+AEG P P I W      ++ + DD R +  +   G+L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
               I + R+S  D+GVY C+ARN  GEA + +A L  + L  +  F   P D  V +G 
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL--RDDFRQNPSDVMVAVGE 146

Query: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR-DHGRFTCHANNS 403
              +EC    GHP P I+W +D     D    +    G  +   T++ D G++ C   N 
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206

Query: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
            G  ++  A + V   P F   P +  V  + + E+ CEA G+P P + W K  G+LP +
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-K 265

Query: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAV-FTQLPQDTS 521
            ++ +    TL+I +    D G Y C A + +G  + S  LTV+  +    F   P+D  
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV 325

Query: 522 VEVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFP 573
           V +G+ +   C A G PQP I W +EG Q           S +F V   G LTI +    
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385

Query: 574 DQGRYECVARNSFGLAVTNMFLTVTAI 600
           D G Y C   N  G  +T  +L VT +
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDV 412



 Score =  128 bits (322), Expect = 4e-29
 Identities = 94/318 (29%), Positives = 141/318 (44%), Gaps = 24/318 (7%)

Query: 221 VASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDT 280
           VA +TV E     P     P ++ V   ++  F C A G+P P + W  ++  L     +
Sbjct: 214 VAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKS 266

Query: 281 RLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE 340
           R  + DD TL IR     D G Y C+A N  G+A+  SA L        P FV++P+D  
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQVGSEPPHFVVKPRDQV 325

Query: 341 VLIGTSTTLECMATGHPHPLITWTRDNGLEL--------DGSRHVATSSG-LYLQNITQR 391
           V +G + T +C ATG+P P I W R+    L          SR   + +G L + N+ + 
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385

Query: 392 DHGRFTCHANNSHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGN 445
           D G + C   N  G++   A + V      + PP     P +Q V  +      C A G+
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445

Query: 446 PPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLT 504
           P P I+W K G  +  +      L +G L+I  A   D G+Y C A +  G    S  + 
Sbjct: 446 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 505

Query: 505 VKPKALAVFTQLPQDTSV 522
           V+   + V    P D ++
Sbjct: 506 VQEFGVPVQPPRPTDPNL 523



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 68/210 (32%), Positives = 96/210 (45%), Gaps = 11/210 (5%)

Query: 218 GRAVASVTVE-EFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL 276
           G+A AS T+  +   + P    +P+D  V  G TV F C A GNP+P I W        L
Sbjct: 298 GKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLL 357

Query: 277 ------EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKP 330
                 +  +R +V   G L I N + SD G Y C   N AG   T++ +     +  +P
Sbjct: 358 FSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417

Query: 331 SFVIQ--PQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL-ELDGSRHVATSSG-LYLQ 386
             VI+  P +  V +  +  L C+ATG P P I W +D  L     SR     +G L ++
Sbjct: 418 PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477

Query: 387 NITQRDHGRFTCHANNSHGTVQAAANIIVQ 416
                D GR+TC A+   G    +A I VQ
Sbjct: 478 YAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 13/182 (7%)

Query: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE-----GQHTVLSSGT 472
           PP+    P D +V +       C+A+G P P I W K G ++  +         +L SG+
Sbjct: 28  PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87

Query: 473 ---LRI--DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALA-VFTQLPQDTSVEVGK 526
              LRI   R ++ D+G Y C A + LG + VS   +++   L   F Q P D  V VG+
Sbjct: 88  LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 527 NINISCH-AQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + C   +G P+P I+W K+G  + +  +      G L I      D G+Y CV  N 
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206

Query: 586 FG 587
            G
Sbjct: 207 VG 208


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score =  188 bits (477), Expect = 4e-47
 Identities = 126/376 (33%), Positives = 185/376 (49%), Gaps = 24/376 (6%)

Query: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
           P DV V  G      C+   G+P+P I W  +   LD + D R+ +   G LMI  TR+S
Sbjct: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKS 194

Query: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
           D G Y C+  N  GE +++ A L   ++  +PSFV +P +  V +  S   +C A G P 
Sbjct: 195 DAGKYVCVGTNMVGERESEVAEL---TVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251

Query: 359 PLITWTRDNGLELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
           P + W +D+G EL  SR+ +     L ++ +T  D G +TC A N  G  +A+A + VQ 
Sbjct: 252 PTVRWRKDDG-ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310

Query: 418 ---PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EGQHT 466
              PP F V P+DQVV     V + CEA GNP P I W + G Q  +          + +
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370

Query: 467 VLSSGTLRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLT--VKPKALAVFTQLPQDTSV 522
           V  +G L I    + D G Y CQ ++  G  + K  +++T  +  +   V  Q P + +V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430

Query: 523 EVGKNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGRYECV 581
            V     +SC A G P P I W K+GV + T+  +    + G L I  A   D GRY C+
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 490

Query: 582 ARNSFGLAVTNMFLTV 597
           A    G A  + ++ V
Sbjct: 491 ASTPSGEATWSAYIEV 506



 Score =  184 bits (467), Expect = 5e-46
 Identities = 123/387 (31%), Positives = 180/387 (46%), Gaps = 23/387 (5%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290
           PRI   P D+ V  G      C+AEG P P I W      ++ + DD R +  +   G+L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
               I + R+S  D+GVY C+ARN  GEA + +A L  + L  +  F   P D  V +G 
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL--RDDFRQNPSDVMVAVGE 146

Query: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR-DHGRFTCHANNS 403
              +EC    GHP P I+W +D     D    +    G  +   T++ D G++ C   N 
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206

Query: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
            G  ++  A + V   P F   P +  V  + + E+ CEA G+P P + W K  G+LP +
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-K 265

Query: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAV-FTQLPQDTS 521
            ++ +    TL+I +    D G Y C A + +G  + S  LTV+  +    F   P+D  
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV 325

Query: 522 VEVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFP 573
           V +G+ +   C A G PQP I W +EG Q           S +F V   G LTI +    
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385

Query: 574 DQGRYECVARNSFGLAVTNMFLTVTAI 600
           D G Y C   N  G  +T  +L VT +
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDV 412



 Score =  128 bits (322), Expect = 4e-29
 Identities = 94/318 (29%), Positives = 141/318 (44%), Gaps = 24/318 (7%)

Query: 221 VASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDT 280
           VA +TV E     P     P ++ V   ++  F C A G+P P + W  ++  L     +
Sbjct: 214 VAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKS 266

Query: 281 RLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE 340
           R  + DD TL IR     D G Y C+A N  G+A+  SA L        P FV++P+D  
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQVGSEPPHFVVKPRDQV 325

Query: 341 VLIGTSTTLECMATGHPHPLITWTRDNGLEL--------DGSRHVATSSG-LYLQNITQR 391
           V +G + T +C ATG+P P I W R+    L          SR   + +G L + N+ + 
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385

Query: 392 DHGRFTCHANNSHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGN 445
           D G + C   N  G++   A + V      + PP     P +Q V  +      C A G+
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445

Query: 446 PPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLT 504
           P P I+W K G  +  +      L +G L+I  A   D G+Y C A +  G    S  + 
Sbjct: 446 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 505

Query: 505 VKPKALAVFTQLPQDTSV 522
           V+   + V    P D ++
Sbjct: 506 VQEFGVPVQPPRPTDPNL 523



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 68/210 (32%), Positives = 96/210 (45%), Gaps = 11/210 (5%)

Query: 218 GRAVASVTVE-EFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL 276
           G+A AS T+  +   + P    +P+D  V  G TV F C A GNP+P I W        L
Sbjct: 298 GKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLL 357

Query: 277 ------EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKP 330
                 +  +R +V   G L I N + SD G Y C   N AG   T++ +     +  +P
Sbjct: 358 FSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417

Query: 331 SFVIQ--PQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL-ELDGSRHVATSSG-LYLQ 386
             VI+  P +  V +  +  L C+ATG P P I W +D  L     SR     +G L ++
Sbjct: 418 PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477

Query: 387 NITQRDHGRFTCHANNSHGTVQAAANIIVQ 416
                D GR+TC A+   G    +A I VQ
Sbjct: 478 YAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 13/182 (7%)

Query: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE-----GQHTVLSSGT 472
           PP+    P D +V +       C+A+G P P I W K G ++  +         +L SG+
Sbjct: 28  PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87

Query: 473 ---LRI--DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALA-VFTQLPQDTSVEVGK 526
              LRI   R ++ D+G Y C A + LG + VS   +++   L   F Q P D  V VG+
Sbjct: 88  LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 527 NINISCH-AQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + C   +G P+P I+W K+G  + +  +      G L I      D G+Y CV  N 
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206

Query: 586 FG 587
            G
Sbjct: 207 VG 208


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score =  188 bits (477), Expect = 4e-47
 Identities = 126/376 (33%), Positives = 185/376 (49%), Gaps = 24/376 (6%)

Query: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
           P DV V  G      C+   G+P+P I W  +   LD + D R+ +   G LMI  TR+S
Sbjct: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKS 194

Query: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
           D G Y C+  N  GE +++ A L   ++  +PSFV +P +  V +  S   +C A G P 
Sbjct: 195 DAGKYVCVGTNMVGERESEVAEL---TVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251

Query: 359 PLITWTRDNGLELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
           P + W +D+G EL  SR+ +     L ++ +T  D G +TC A N  G  +A+A + VQ 
Sbjct: 252 PTVRWRKDDG-ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310

Query: 418 ---PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EGQHT 466
              PP F V P+DQVV     V + CEA GNP P I W + G Q  +          + +
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370

Query: 467 VLSSGTLRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLT--VKPKALAVFTQLPQDTSV 522
           V  +G L I    + D G Y CQ ++  G  + K  +++T  +  +   V  Q P + +V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430

Query: 523 EVGKNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGRYECV 581
            V     +SC A G P P I W K+GV + T+  +    + G L I  A   D GRY C+
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 490

Query: 582 ARNSFGLAVTNMFLTV 597
           A    G A  + ++ V
Sbjct: 491 ASTPSGEATWSAYIEV 506



 Score =  184 bits (467), Expect = 5e-46
 Identities = 123/387 (31%), Positives = 180/387 (46%), Gaps = 23/387 (5%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290
           PRI   P D+ V  G      C+AEG P P I W      ++ + DD R +  +   G+L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
               I + R+S  D+GVY C+ARN  GEA + +A L  + L  +  F   P D  V +G 
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL--RDDFRQNPSDVMVAVGE 146

Query: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR-DHGRFTCHANNS 403
              +EC    GHP P I+W +D     D    +    G  +   T++ D G++ C   N 
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206

Query: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
            G  ++  A + V   P F   P +  V  + + E+ CEA G+P P + W K  G+LP +
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-K 265

Query: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAV-FTQLPQDTS 521
            ++ +    TL+I +    D G Y C A + +G  + S  LTV+  +    F   P+D  
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV 325

Query: 522 VEVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFP 573
           V +G+ +   C A G PQP I W +EG Q           S +F V   G LTI +    
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385

Query: 574 DQGRYECVARNSFGLAVTNMFLTVTAI 600
           D G Y C   N  G  +T  +L VT +
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDV 412



 Score =  128 bits (322), Expect = 4e-29
 Identities = 94/318 (29%), Positives = 141/318 (44%), Gaps = 24/318 (7%)

Query: 221 VASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDT 280
           VA +TV E     P     P ++ V   ++  F C A G+P P + W  ++  L     +
Sbjct: 214 VAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKS 266

Query: 281 RLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE 340
           R  + DD TL IR     D G Y C+A N  G+A+  SA L        P FV++P+D  
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQVGSEPPHFVVKPRDQV 325

Query: 341 VLIGTSTTLECMATGHPHPLITWTRDNGLEL--------DGSRHVATSSG-LYLQNITQR 391
           V +G + T +C ATG+P P I W R+    L          SR   + +G L + N+ + 
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385

Query: 392 DHGRFTCHANNSHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGN 445
           D G + C   N  G++   A + V      + PP     P +Q V  +      C A G+
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445

Query: 446 PPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLT 504
           P P I+W K G  +  +      L +G L+I  A   D G+Y C A +  G    S  + 
Sbjct: 446 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 505

Query: 505 VKPKALAVFTQLPQDTSV 522
           V+   + V    P D ++
Sbjct: 506 VQEFGVPVQPPRPTDPNL 523



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 68/210 (32%), Positives = 96/210 (45%), Gaps = 11/210 (5%)

Query: 218 GRAVASVTVE-EFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL 276
           G+A AS T+  +   + P    +P+D  V  G TV F C A GNP+P I W        L
Sbjct: 298 GKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLL 357

Query: 277 ------EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKP 330
                 +  +R +V   G L I N + SD G Y C   N AG   T++ +     +  +P
Sbjct: 358 FSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417

Query: 331 SFVIQ--PQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL-ELDGSRHVATSSG-LYLQ 386
             VI+  P +  V +  +  L C+ATG P P I W +D  L     SR     +G L ++
Sbjct: 418 PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477

Query: 387 NITQRDHGRFTCHANNSHGTVQAAANIIVQ 416
                D GR+TC A+   G    +A I VQ
Sbjct: 478 YAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 13/182 (7%)

Query: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE-----GQHTVLSSGT 472
           PP+    P D +V +       C+A+G P P I W K G ++  +         +L SG+
Sbjct: 28  PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87

Query: 473 ---LRI--DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALA-VFTQLPQDTSVEVGK 526
              LRI   R ++ D+G Y C A + LG + VS   +++   L   F Q P D  V VG+
Sbjct: 88  LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 527 NINISCH-AQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + C   +G P+P I+W K+G  + +  +      G L I      D G+Y CV  N 
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206

Query: 586 FG 587
            G
Sbjct: 207 VG 208


>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
           sapiens]
          Length = 1615

 Score =  188 bits (477), Expect = 4e-47
 Identities = 126/376 (33%), Positives = 185/376 (49%), Gaps = 24/376 (6%)

Query: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
           P DV V  G      C+   G+P+P I W  +   LD + D R+ +   G LMI  TR+S
Sbjct: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKS 194

Query: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
           D G Y C+  N  GE +++ A L   ++  +PSFV +P +  V +  S   +C A G P 
Sbjct: 195 DAGKYVCVGTNMVGERESEVAEL---TVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251

Query: 359 PLITWTRDNGLELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
           P + W +D+G EL  SR+ +     L ++ +T  D G +TC A N  G  +A+A + VQ 
Sbjct: 252 PTVRWRKDDG-ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310

Query: 418 ---PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EGQHT 466
              PP F V P+DQVV     V + CEA GNP P I W + G Q  +          + +
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370

Query: 467 VLSSGTLRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLT--VKPKALAVFTQLPQDTSV 522
           V  +G L I    + D G Y CQ ++  G  + K  +++T  +  +   V  Q P + +V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430

Query: 523 EVGKNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGRYECV 581
            V     +SC A G P P I W K+GV + T+  +    + G L I  A   D GRY C+
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 490

Query: 582 ARNSFGLAVTNMFLTV 597
           A    G A  + ++ V
Sbjct: 491 ASTPSGEATWSAYIEV 506



 Score =  184 bits (467), Expect = 5e-46
 Identities = 123/387 (31%), Positives = 180/387 (46%), Gaps = 23/387 (5%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290
           PRI   P D+ V  G      C+AEG P P I W      ++ + DD R +  +   G+L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
               I + R+S  D+GVY C+ARN  GEA + +A L  + L  +  F   P D  V +G 
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL--RDDFRQNPSDVMVAVGE 146

Query: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR-DHGRFTCHANNS 403
              +EC    GHP P I+W +D     D    +    G  +   T++ D G++ C   N 
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206

Query: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
            G  ++  A + V   P F   P +  V  + + E+ CEA G+P P + W K  G+LP +
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-K 265

Query: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAV-FTQLPQDTS 521
            ++ +    TL+I +    D G Y C A + +G  + S  LTV+  +    F   P+D  
Sbjct: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV 325

Query: 522 VEVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFP 573
           V +G+ +   C A G PQP I W +EG Q           S +F V   G LTI +    
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385

Query: 574 DQGRYECVARNSFGLAVTNMFLTVTAI 600
           D G Y C   N  G  +T  +L VT +
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDV 412



 Score =  128 bits (322), Expect = 4e-29
 Identities = 94/318 (29%), Positives = 141/318 (44%), Gaps = 24/318 (7%)

Query: 221 VASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDT 280
           VA +TV E     P     P ++ V   ++  F C A G+P P + W  ++  L     +
Sbjct: 214 VAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKS 266

Query: 281 RLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE 340
           R  + DD TL IR     D G Y C+A N  G+A+  SA L        P FV++P+D  
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQVGSEPPHFVVKPRDQV 325

Query: 341 VLIGTSTTLECMATGHPHPLITWTRDNGLEL--------DGSRHVATSSG-LYLQNITQR 391
           V +G + T +C ATG+P P I W R+    L          SR   + +G L + N+ + 
Sbjct: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385

Query: 392 DHGRFTCHANNSHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGN 445
           D G + C   N  G++   A + V      + PP     P +Q V  +      C A G+
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445

Query: 446 PPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLT 504
           P P I+W K G  +  +      L +G L+I  A   D G+Y C A +  G    S  + 
Sbjct: 446 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 505

Query: 505 VKPKALAVFTQLPQDTSV 522
           V+   + V    P D ++
Sbjct: 506 VQEFGVPVQPPRPTDPNL 523



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 68/210 (32%), Positives = 96/210 (45%), Gaps = 11/210 (5%)

Query: 218 GRAVASVTVE-EFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL 276
           G+A AS T+  +   + P    +P+D  V  G TV F C A GNP+P I W        L
Sbjct: 298 GKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLL 357

Query: 277 ------EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKP 330
                 +  +R +V   G L I N + SD G Y C   N AG   T++ +     +  +P
Sbjct: 358 FSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417

Query: 331 SFVIQ--PQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL-ELDGSRHVATSSG-LYLQ 386
             VI+  P +  V +  +  L C+ATG P P I W +D  L     SR     +G L ++
Sbjct: 418 PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477

Query: 387 NITQRDHGRFTCHANNSHGTVQAAANIIVQ 416
                D GR+TC A+   G    +A I VQ
Sbjct: 478 YAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 13/182 (7%)

Query: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE-----GQHTVLSSGT 472
           PP+    P D +V +       C+A+G P P I W K G ++  +         +L SG+
Sbjct: 28  PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87

Query: 473 ---LRI--DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALA-VFTQLPQDTSVEVGK 526
              LRI   R ++ D+G Y C A + LG + VS   +++   L   F Q P D  V VG+
Sbjct: 88  LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 527 NINISCH-AQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + C   +G P+P I+W K+G  + +  +      G L I      D G+Y CV  N 
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206

Query: 586 FG 587
            G
Sbjct: 207 VG 208


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
           sapiens]
          Length = 1386

 Score =  185 bits (469), Expect = 3e-46
 Identities = 116/370 (31%), Positives = 180/370 (48%), Gaps = 19/370 (5%)

Query: 240 PQDVEVPSGNTVYFTC-RAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
           P +V V  G      C    G+P+P + W  +   L  E++ R+ +   G LM+ +T +S
Sbjct: 172 PGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLK-EEEGRITI-RGGKLMMSHTLKS 229

Query: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
           D G+Y C+A N AGE ++ +A +       +PSF+ +P +  VL     T  C   G P 
Sbjct: 230 DAGMYVCVASNMAGERESAAAEVMVLE---RPSFLRRPVNQVVLADAPVTFLCEVKGDPP 286

Query: 359 PLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAP 418
           P + W +++G    G   + +   L++ +++  D G +TC A NS G  +A+ ++ V  P
Sbjct: 287 PRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346

Query: 419 PQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQ--------LPVEGQHTVLSS 470
           PQ    P+DQ+     +V + CE  GNPPP I W K G Q        L   G+ +V   
Sbjct: 347 PQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPR 406

Query: 471 GTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKAL----AVFTQLPQDTSVEVGK 526
           G L I    + D G Y CQAVS  G       L +K  +L     V  Q P + ++ +G 
Sbjct: 407 GQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGS 466

Query: 527 NINISCHAQGEPQPIITWNKEGVQIT-ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
           ++ + C   G PQP + W K+G  +  +  +F     GTL I +    D G Y CVA++S
Sbjct: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSS 526

Query: 586 FGLAVTNMFL 595
            G A  + +L
Sbjct: 527 TGEATWSGWL 536



 Score =  182 bits (461), Expect = 3e-45
 Identities = 125/383 (32%), Positives = 184/383 (48%), Gaps = 24/383 (6%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSL-DLEDDTRLN--VFDDGTL 290
           PRI  +P D+ V  G      CRAEG P+P I W  N   +  + +D R +  +   G L
Sbjct: 64  PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123

Query: 291 ----MIRNTR-ESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
               ++   R   D+GVY C+ARN  G A +++A L  + L  +  F   P +  V +G 
Sbjct: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVL--RDDFRQSPGNVVVAVGE 181

Query: 346 STTLECM-ATGHPHPLITWTRDNG-LELDGSRHVATSSGLYLQNITQRDHGRFTCHANNS 403
              LEC+   GHP P ++W +D   L+ +  R       L + +  + D G + C A+N 
Sbjct: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNM 241

Query: 404 HGTVQ-AAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
            G  + AAA ++V   P F   P +QVVL +  V +LCE  G+PPP + W K  G+LP  
Sbjct: 242 AGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT- 300

Query: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV 522
           G++ + S  +L I   +  D+G Y C A +S+G  + S  L+V      V TQ PQD   
Sbjct: 301 GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV-TQ-PQDQMA 358

Query: 523 EVGKNINISCHAQGEPQPIITWNKEGVQI--------TESGKFHVDDEGTLTIYDAGFPD 574
             G+++   C  +G P P I W KEG Q+          +G+F V   G L I      D
Sbjct: 359 APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGD 418

Query: 575 QGRYECVARNSFGLAVTNMFLTV 597
            G Y C A +  G  +    L +
Sbjct: 419 AGYYVCQAVSVAGSILAKALLEI 441



 Score =  111 bits (278), Expect = 4e-24
 Identities = 79/289 (27%), Positives = 121/289 (41%), Gaps = 23/289 (7%)

Query: 223 SVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRL 282
           S   E    + P     P +  V +   V F C  +G+P P + W   +  L      R 
Sbjct: 247 SAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL---PTGRY 303

Query: 283 NVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVL 342
            +  D +L I +    D+G Y C+A NS G A+   ++    S+   P  V QPQD    
Sbjct: 304 EIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSL----SVHVPPQLVTQPQDQMAA 359

Query: 343 IGTSTTLECMATGHPHPLITWTRD---------NGLELDGSRHVATSSGLYLQNITQRDH 393
            G S   +C   G+P P I W ++           L+  G   V+    L +  + + D 
Sbjct: 360 PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419

Query: 394 GRFTCHANNSHGTVQAAANIIVQA------PPQFTVTPKDQVVLEEHAVEWLCEADGNPP 447
           G + C A +  G++ A A + ++       PP     P +Q ++   +V   C   GNP 
Sbjct: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQ 479

Query: 448 PVIVWTKTGGQLPVEG-QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLG 495
           P + W K G  L  +  Q   +++GTL I    + D G Y C A SS G
Sbjct: 480 PSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTG 528



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 81/285 (28%), Positives = 120/285 (42%), Gaps = 18/285 (6%)

Query: 328 AKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLEL-------DGSRHVATS 380
           A P  V QP D  V  G   TL C A G P P I W + NG  +          R +  S
Sbjct: 62  AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYK-NGARVATVREDPRAHRLLLPS 120

Query: 381 SGLYLQNI-----TQRDHGRFTCHANNSHGTVQA--AANIIVQAPPQFTVTPKDQVV-LE 432
             L+   I      + D G +TC A N  G   +  A+  +      F  +P + VV + 
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG 180

Query: 433 EHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVS 492
           E AV       G+P P + W K G +L  E     +  G L +    + D G Y C A S
Sbjct: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVA-S 239

Query: 493 SLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQIT 552
           ++  ++ S    V       F + P +  V     +   C  +G+P P + W KE  ++ 
Sbjct: 240 NMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL- 298

Query: 553 ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
            +G++ +  + +L I      D+G Y CVA NS G A  +  L+V
Sbjct: 299 PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV 343



 Score = 60.8 bits (146), Expect = 9e-09
 Identities = 42/122 (34%), Positives = 58/122 (47%), Gaps = 19/122 (15%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
           P I   P +  +  G++V+  CR  GNP+P + W  +   L   DD +     +GTL I 
Sbjct: 451 PVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQ-GDDLQFKTMANGTLYIA 509

Query: 294 NTRESDQGVYQCMARNSAGEAKTQSAMLRY--------------SSLPAKPSFVIQPQDT 339
           N +E D G Y C+A++S GEA T S  L+               SS P  PS   QP  T
Sbjct: 510 NVQEMDMGFYSCVAKSSTGEA-TWSGWLKMREDWGVSPDPPTEPSSPPGAPS---QPVVT 565

Query: 340 EV 341
           E+
Sbjct: 566 EI 567



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 36/115 (31%), Positives = 51/115 (44%), Gaps = 16/115 (13%)

Query: 509 ALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQIT---ESGKFH--VDDEG 563
           A+    + P D  V  G+   + C A+G P+P I W K G ++    E  + H  +   G
Sbjct: 62  AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121

Query: 564 TLTI-----YDAGFPDQGRYECVARNSFGLAVT-NMFLTVTAIQGRQAGDDFVES 612
            L            PD+G Y CVARN  G A + N  L V  ++     DDF +S
Sbjct: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLR-----DDFRQS 171


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  184 bits (466), Expect = 7e-46
 Identities = 117/373 (31%), Positives = 179/373 (47%), Gaps = 19/373 (5%)

Query: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
           P DV V +G      C+   G+P+P I W  +   +D + + R+++   G LMI NTR+S
Sbjct: 155 PTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRID-DKEERISI-RGGKLMISNTRKS 212

Query: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
           D G+Y C+  N  GE  +  A L   ++  +P+F+ +P +  VL   +    C   G P 
Sbjct: 213 DAGMYTCVGTNMVGERDSDPAEL---TVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 269

Query: 359 PLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAP 418
           P + W +D+     G   +     L ++     D G + C A N  G ++A+A + V+AP
Sbjct: 270 PTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 329

Query: 419 PQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQ---LPVEGQH-----TVLSS 470
           PQF V P+DQ+V +   V + CE  GNP P + W K G Q    P + Q      +V  +
Sbjct: 330 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 389

Query: 471 GTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV----KPKALAVFTQLPQDTSVEVGK 526
           G L I    + D G Y CQA++  G      QL V      +   +  Q P + ++ V  
Sbjct: 390 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 449

Query: 527 NINISCHAQGEPQPIITWNKEGVQIT-ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + C A G+P P+I+W KEG        +  + ++GTL I +    D G Y CVA +S
Sbjct: 450 TALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSS 509

Query: 586 FGLAVTNMFLTVT 598
            G    +  L VT
Sbjct: 510 SGETSWSAVLDVT 522



 Score =  181 bits (459), Expect = 5e-45
 Identities = 129/386 (33%), Positives = 177/386 (45%), Gaps = 24/386 (6%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290
           PRI   P DV V  G      C+AEG P P I W  +   ++ + DD R +  +   G+L
Sbjct: 47  PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 106

Query: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
               I + R S  D+G Y C+ARN  GEA +++A L  + L  +  F   P D  V  G 
Sbjct: 107 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALL--RDDFRQNPTDVVVAAGE 164

Query: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSG-LYLQNITQRDHGRFTCHANNS 403
              LEC    GHP P I W +D     D    ++   G L + N  + D G +TC   N 
Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM 224

Query: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
            G   +  A + V   P F   P +QVVLEE AVE+ C+  G+P P + W K    LP  
Sbjct: 225 VGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP-R 283

Query: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV 522
           G++ +    TLRI +    D+G Y C A + +G  + S  LTV  +A   F   P+D  V
Sbjct: 284 GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVRPRDQIV 341

Query: 523 EVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFPD 574
             G+ +   C  +G PQP + W KEG Q           + +  V   G LTI +    D
Sbjct: 342 AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSD 401

Query: 575 QGRYECVARNSFGLAVTNMFLTVTAI 600
            G Y C A    G  +    L VT +
Sbjct: 402 AGYYICQALTVAGSILAKAQLEVTDV 427



 Score =  125 bits (313), Expect = 4e-28
 Identities = 83/290 (28%), Positives = 131/290 (45%), Gaps = 23/290 (7%)

Query: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM 291
           + P     P +  V     V F C+ +G+P+P + W  ++  L      R ++ DD TL 
Sbjct: 239 ERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL---PRGRYDIKDDYTLR 295

Query: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351
           I+ T  +D+G Y C+A N  G+ +  + +    ++ A P FV++P+D  V  G + T  C
Sbjct: 296 IKKTMSTDEGTYMCIAENRVGKMEASATL----TVRAPPQFVVRPRDQIVAQGRTVTFPC 351

Query: 352 MATGHPHPLITWTRDNGLEL---------DGSRHVATSSGLYLQNITQRDHGRFTCHANN 402
              G+P P + W ++    L         +    V+ +  L + NI + D G + C A  
Sbjct: 352 ETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALT 411

Query: 403 SHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTG 456
             G++ A A + V      + PP     P +Q +  +      C+A G+P PVI W K G
Sbjct: 412 VAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG 471

Query: 457 GQLP-VEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
              P  + + T+   GTL+I      D G Y C A SS G    S  L V
Sbjct: 472 FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 521



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 56/182 (30%), Positives = 83/182 (45%), Gaps = 13/182 (7%)

Query: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE-----GQHTVLSSGT 472
           PP+    P D +V +       C+A+G P P I W K G ++  +         +L SG+
Sbjct: 46  PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105

Query: 473 ---LRI--DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALA-VFTQLPQDTSVEVGK 526
              LRI   R ++ D+G Y C A + LG + VS   +++   L   F Q P D  V  G+
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLG-EAVSRNASLEVALLRDDFRQNPTDVVVAAGE 164

Query: 527 NINISCH-AQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + C   +G P+P I W K+ V+I +  +      G L I +    D G Y CV  N 
Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM 224

Query: 586 FG 587
            G
Sbjct: 225 VG 226


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  184 bits (466), Expect = 7e-46
 Identities = 117/373 (31%), Positives = 179/373 (47%), Gaps = 19/373 (5%)

Query: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
           P DV V +G      C+   G+P+P I W  +   +D + + R+++   G LMI NTR+S
Sbjct: 139 PTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRID-DKEERISI-RGGKLMISNTRKS 196

Query: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
           D G+Y C+  N  GE  +  A L   ++  +P+F+ +P +  VL   +    C   G P 
Sbjct: 197 DAGMYTCVGTNMVGERDSDPAEL---TVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 253

Query: 359 PLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAP 418
           P + W +D+     G   +     L ++     D G + C A N  G ++A+A + V+AP
Sbjct: 254 PTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 313

Query: 419 PQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQ---LPVEGQH-----TVLSS 470
           PQF V P+DQ+V +   V + CE  GNP P + W K G Q    P + Q      +V  +
Sbjct: 314 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373

Query: 471 GTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV----KPKALAVFTQLPQDTSVEVGK 526
           G L I    + D G Y CQA++  G      QL V      +   +  Q P + ++ V  
Sbjct: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 433

Query: 527 NINISCHAQGEPQPIITWNKEGVQIT-ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + C A G+P P+I+W KEG        +  + ++GTL I +    D G Y CVA +S
Sbjct: 434 TALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSS 493

Query: 586 FGLAVTNMFLTVT 598
            G    +  L VT
Sbjct: 494 SGETSWSAVLDVT 506



 Score =  181 bits (459), Expect = 5e-45
 Identities = 129/386 (33%), Positives = 177/386 (45%), Gaps = 24/386 (6%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290
           PRI   P DV V  G      C+AEG P P I W  +   ++ + DD R +  +   G+L
Sbjct: 31  PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90

Query: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
               I + R S  D+G Y C+ARN  GEA +++A L  + L  +  F   P D  V  G 
Sbjct: 91  FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALL--RDDFRQNPTDVVVAAGE 148

Query: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSG-LYLQNITQRDHGRFTCHANNS 403
              LEC    GHP P I W +D     D    ++   G L + N  + D G +TC   N 
Sbjct: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM 208

Query: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
            G   +  A + V   P F   P +QVVLEE AVE+ C+  G+P P + W K    LP  
Sbjct: 209 VGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP-R 267

Query: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV 522
           G++ +    TLRI +    D+G Y C A + +G  + S  LTV  +A   F   P+D  V
Sbjct: 268 GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVRPRDQIV 325

Query: 523 EVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFPD 574
             G+ +   C  +G PQP + W KEG Q           + +  V   G LTI +    D
Sbjct: 326 AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSD 385

Query: 575 QGRYECVARNSFGLAVTNMFLTVTAI 600
            G Y C A    G  +    L VT +
Sbjct: 386 AGYYICQALTVAGSILAKAQLEVTDV 411



 Score =  125 bits (313), Expect = 4e-28
 Identities = 83/290 (28%), Positives = 131/290 (45%), Gaps = 23/290 (7%)

Query: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM 291
           + P     P +  V     V F C+ +G+P+P + W  ++  L      R ++ DD TL 
Sbjct: 223 ERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL---PRGRYDIKDDYTLR 279

Query: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351
           I+ T  +D+G Y C+A N  G+ +  + +    ++ A P FV++P+D  V  G + T  C
Sbjct: 280 IKKTMSTDEGTYMCIAENRVGKMEASATL----TVRAPPQFVVRPRDQIVAQGRTVTFPC 335

Query: 352 MATGHPHPLITWTRDNGLEL---------DGSRHVATSSGLYLQNITQRDHGRFTCHANN 402
              G+P P + W ++    L         +    V+ +  L + NI + D G + C A  
Sbjct: 336 ETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALT 395

Query: 403 SHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTG 456
             G++ A A + V      + PP     P +Q +  +      C+A G+P PVI W K G
Sbjct: 396 VAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG 455

Query: 457 GQLP-VEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
              P  + + T+   GTL+I      D G Y C A SS G    S  L V
Sbjct: 456 FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 56/182 (30%), Positives = 83/182 (45%), Gaps = 13/182 (7%)

Query: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE-----GQHTVLSSGT 472
           PP+    P D +V +       C+A+G P P I W K G ++  +         +L SG+
Sbjct: 30  PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89

Query: 473 ---LRI--DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALA-VFTQLPQDTSVEVGK 526
              LRI   R ++ D+G Y C A + LG + VS   +++   L   F Q P D  V  G+
Sbjct: 90  LFFLRIVHGRRSKPDEGSYVCVARNYLG-EAVSRNASLEVALLRDDFRQNPTDVVVAAGE 148

Query: 527 NINISCH-AQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + C   +G P+P I W K+ V+I +  +      G L I +    D G Y CV  N 
Sbjct: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM 208

Query: 586 FG 587
            G
Sbjct: 209 VG 210


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  175 bits (443), Expect = 3e-43
 Identities = 124/388 (31%), Positives = 169/388 (43%), Gaps = 22/388 (5%)

Query: 225  TVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNV 284
            TV  +    P ++     V V  G      C A G P P +IW      + L  +     
Sbjct: 689  TVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--- 745

Query: 285  FDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIG 344
               G L I   +E D G Y C A N  G+A  +  +    ++   P     P+D  V +G
Sbjct: 746  -SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL----AVGHAPQLTELPRDVTVELG 800

Query: 345  TSTTLECMATGHPHPLITWTRDNGLELD-------GSRHVATSSG-LYLQNITQRDHGRF 396
             S  L C ATG P P +TW R +G  L        GSR     SG L+ +++   D   +
Sbjct: 801  RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 860

Query: 397  TCHANNSHGTVQAAANIIV--QAPPQFTVTPKDQVVLEEHAVEWLCEA-DGNPPPVIVWT 453
             C A N  G VQA A +IV   APPQ   +     VLE   V   C    G P P   W 
Sbjct: 861  VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWL 920

Query: 454  KTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVF 513
            K G  LP   +H++ + G+L +DRA Q   G+Y C A ++ G +   V+L V+       
Sbjct: 921  KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHP 980

Query: 514  TQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGK-FHVDDEGTLTIYDAGF 572
            T     T+   G   ++ C A G P P ITW KE   +T  G  ++V  EGTL I     
Sbjct: 981  TATHHITNE--GVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSA 1038

Query: 573  PDQGRYECVARNSFGLAVTNMFLTVTAI 600
             D G Y C A N+ G +   M L+V  +
Sbjct: 1039 QDAGAYVCTATNTVGFSSQEMRLSVNRL 1066



 Score =  174 bits (441), Expect = 6e-43
 Identities = 119/416 (28%), Positives = 186/416 (44%), Gaps = 44/416 (10%)

Query: 242  DVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQG 301
            D+    G+  +  C+A G+P+P I W  +   +   +  +  +   G L+++N    D G
Sbjct: 4046 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEG-KFTIQPSGELLVKNLEGQDAG 4104

Query: 302  VYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLI 361
             Y C A N+ G A+ +  +    ++   P F   P D  + +G    L C A G P P I
Sbjct: 4105 TYTCTAENAVGRARRRVHL----TILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRI 4160

Query: 362  TWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQF 421
             WT ++    +G       S L    +++ D G + C A N  G  QA + + V+  P  
Sbjct: 4161 GWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-- 4218

Query: 422  TVTPKDQVVLEEHAVEWL-----------CEADGNPPPVIVWTKTGGQLPVEGQHT--VL 468
                    VL+  A  +L           C   G+P P I W K G  LP+ G H    L
Sbjct: 4219 --------VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDG--LPLRGSHLRHQL 4268

Query: 469  SSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNI 528
             +G+L I R  + D G+Y+C A + +GV K  V L ++  +  VF   PQD +V  G ++
Sbjct: 4269 QNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQ--SAPVFQVEPQDMTVRSGDDV 4326

Query: 529  NISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGL 588
             + C A GEP P I W + G  +  S +     +G+L + +    D G Y+CVA N  G 
Sbjct: 4327 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGS 4386

Query: 589  AVTNMFLTVT------------AIQGRQAGDDFVESSILDAVQRVDSAINSTRRHL 632
            A    FL V              I GR+ G   + +S++       S+I+S+ RH+
Sbjct: 4387 ATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSVMQEAHSGVSSIHSSIRHV 4442



 Score =  165 bits (417), Expect = 3e-40
 Identities = 119/370 (32%), Positives = 159/370 (42%), Gaps = 14/370 (3%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P I   P  V V    T    C+A+G P P + W  +   LD     R  +  +G+L I+
Sbjct: 3673 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD-PRSPRFEILPEGSLRIQ 3731

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMA 353
                 D G Y C+A NSAG  + Q   LR    PA       P +  +   T   L C A
Sbjct: 3732 PVLAQDAGHYLCLASNSAGSDR-QGRDLRVLEPPA---IAPSPSNLTLTAHTPALLPCEA 3787

Query: 354  TGHPHPLITWTRDNGLELD-----GSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQ 408
            +G P PL+ W +D G +LD     G+  +  S+ L L     +D  +F C  +N  G   
Sbjct: 3788 SGSPKPLVVWWKD-GQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH 3846

Query: 409  AAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQ-HTV 467
                + V  PP       D  V     V   C + G P P + W+K G QL   G  + V
Sbjct: 3847 RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRV 3906

Query: 468  LSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKN 527
              SG L I +A     G+Y C A +S GV    V LTV  +A  V   LP        + 
Sbjct: 3907 SPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTV--QASPVVKPLPSVVRAVAEEE 3964

Query: 528  INISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
            + + C A G P+P ITW KEG+ +       V   G L I  A   D G Y C+A+NS G
Sbjct: 3965 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAG 4024

Query: 588  LAVTNMFLTV 597
             A+    L V
Sbjct: 4025 SAMGKTRLVV 4034



 Score =  164 bits (416), Expect = 4e-40
 Identities = 114/389 (29%), Positives = 170/389 (43%), Gaps = 21/389 (5%)

Query: 218 GRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE 277
           GRA A + V +     P++   P +V V  G T   +CR  G     + W+ +   L   
Sbjct: 505 GRAKAQIVVTD---PPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 560

Query: 278 DDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQ 337
              R+    D +L I     +D G YQC+A N+ G  +    +L    +   P   I   
Sbjct: 561 TG-RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL----VREAPQVSIHTS 615

Query: 338 DTEVLIGTSTTLECMATGHPHPLITWTRDN-GLELDGSRHVATSSGLYLQNITQRDHGRF 396
                 G    + C A+G+P P I+W+R++  L+ D   HV     L +Q +   D G +
Sbjct: 616 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 675

Query: 397 TCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTG 456
           +C A N  GT Q    +    PP  +      +V        +CEA G PPP ++W + G
Sbjct: 676 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 735

Query: 457 GQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQL 516
            ++ +  + +  SSG LRI  A + D G Y C+AV+ LG     +QL V        T+L
Sbjct: 736 LEMILAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV--GHAPQLTEL 791

Query: 517 PQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQ-------ITESGKFHVDDEGTLTIYD 569
           P+D +VE+G++  ++C A G P P +TW +   Q            +    D G L    
Sbjct: 792 PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFES 851

Query: 570 AGFPDQGRYECVARNSFGLAVTNMFLTVT 598
               DQ  Y C ARN FG       L VT
Sbjct: 852 VAPEDQAPYVCEARNVFGKVQAEARLIVT 880



 Score =  155 bits (391), Expect = 4e-37
 Identities = 107/373 (28%), Positives = 159/373 (42%), Gaps = 10/373 (2%)

Query: 232  QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLNVFDDGTL 290
            + P I   P ++ + +       C A G+PKP ++W  +   LD         +     L
Sbjct: 3762 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNAL 3821

Query: 291  MIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLE 350
            ++      D   ++C+  N  GEA      L   ++   P+      D  V +     L 
Sbjct: 3822 LLTAPGPQDSAQFECVVSNEVGEAHR----LYQVTVHVPPTIADDQTDFTVTMMAPVVLT 3877

Query: 351  CMATGHPHPLITWTRDNG-LELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQ 408
            C +TG P P ++W++    L   GS + V+ S  L +        GR+TC A NS G   
Sbjct: 3878 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 3937

Query: 409  AAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVL 468
                + VQA P     P     + E  V   CEA G P P I W K G  +       VL
Sbjct: 3938 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVL 3997

Query: 469  SSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNI 528
              G LRI  A+  D G Y C A +S G      +L V+   + +   LP D S   G + 
Sbjct: 3998 PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV-IENGLP-DLSTTEGSHA 4055

Query: 529  NISCHAQGEPQPIITWNKEGVQIT-ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
             + C A+G P+P ITW+K+G  ++   GKF +   G L + +    D G Y C A N+ G
Sbjct: 4056 FLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG 4115

Query: 588  LAVTNMFLTVTAI 600
             A   + LT+  +
Sbjct: 4116 RARRRVHLTILVL 4128



 Score =  151 bits (382), Expect = 4e-36
 Identities = 102/353 (28%), Positives = 160/353 (45%), Gaps = 17/353 (4%)

Query: 255  CRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT-LMIRNTRESDQGVYQCMARNSAGE 313
            C  E  P P+I W  +   + L++D      + G  L ++    +D G Y C ARN+AG 
Sbjct: 3603 CSVEAEPAPKITW--HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS 3660

Query: 314  AKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDG 373
                  +     +   P+    P    V +  +  L C A G P PL++W +D  + LD 
Sbjct: 3661 TSVAFRV----EIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR-VPLDP 3715

Query: 374  SR---HVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVV 430
                  +     L +Q +  +D G + C A+NS G+ +   ++ V  PP    +P +  +
Sbjct: 3716 RSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTL 3775

Query: 431  LEEHAVEWLCEADGNPPPVIVWTKTGGQLPV---EGQHTVLSSGTLRIDRAAQHDQGQYE 487
                     CEA G+P P++VW K G +L     +G + +L S  L +      D  Q+E
Sbjct: 3776 TAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFE 3835

Query: 488  CQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKE 547
            C   + +G      Q+TV         Q   D +V +   + ++CH+ G P P ++W+K 
Sbjct: 3836 CVVSNEVGEAHRLYQVTVHVPPTIADDQ--TDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 3893

Query: 548  GVQITESGK-FHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTA 599
            G Q+   G  + V   G L I  A     GRY C ARNS G+A  ++FLTV A
Sbjct: 3894 GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQA 3946



 Score =  150 bits (378), Expect = 1e-35
 Identities = 115/435 (26%), Positives = 173/435 (39%), Gaps = 66/435 (15%)

Query: 222  ASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHS-----LDL 276
            AS  ++     +P++T  P+DV V  G +    CRA G P P + W   +       L  
Sbjct: 774  ASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGA 833

Query: 277  EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQP 336
               +R    D G L   +    DQ  Y C ARN  G+ + ++ ++     P  P      
Sbjct: 834  GRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP--PQIASSA 891

Query: 337  QDTEVLIGTSTTLECMA-TGHPHPLITWTRDNGLELDGSRHVATSSG-LYLQNITQRDHG 394
                VL G   +L C+   G P P   W +D      GSRH   + G L+L    Q   G
Sbjct: 892  PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAG 951

Query: 395  RFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTK 454
            R++C A N+ G+      ++VQ PP+   T    +  E       C A G P P I WTK
Sbjct: 952  RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTK 1011

Query: 455  TGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVF 513
                L   G H  V   GTL I + +  D G Y C A +++G     ++L+V   AL+ +
Sbjct: 1012 ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKY 1071

Query: 514  --------------------------------------------TQLPQDT-------SV 522
                                                         Q+P           V
Sbjct: 1072 VWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKV 1131

Query: 523  EVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVA 582
             VG+ ++++C A+G P+P ++W+K+GV +   G      +G++        D GRY C A
Sbjct: 1132 LVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG-----PQGSVHFAAIRTSDAGRYRCEA 1186

Query: 583  RNSFGLAVTNMFLTV 597
             NS G+    + L V
Sbjct: 1187 SNSAGVDAWEVELRV 1201



 Score =  145 bits (366), Expect = 3e-34
 Identities = 104/366 (28%), Positives = 161/366 (43%), Gaps = 24/366 (6%)

Query: 247  SGNTVYFTCRAEGNPKPEIIWIHNNH-------------SLDLEDDTRLNVFDDG-TLMI 292
            +G ++   C A G P PEI+W+ +                L         + D+G +L  
Sbjct: 1314 AGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHF 1373

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECM 352
               +E D G+Y C A N AG A+    +L  +  P         Q+   L G    L+C 
Sbjct: 1374 PRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT--PPSVLGAGAAQEVLGLAGADVELQCW 1431

Query: 353  ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR---DHGRFTCHANNSHGTVQA 409
             +G P P + WT+D    L G  H+       +  IT     D GR+ C A +  G    
Sbjct: 1432 TSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQAR 1491

Query: 410  AANIIVQAPPQFTVTPK--DQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV 467
               + V APP    + +  +  V+E+H V+ LCEA G P P I W K G  LP   +   
Sbjct: 1492 DFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY 1551

Query: 468  LSSGT-LRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVK-PKALAVFTQLPQDTSVEVG 525
               G  L++ RA   D G Y C+A +++G  + + +L V  P  +      P       G
Sbjct: 1552 TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG 1611

Query: 526  KNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGT-LTIYDAGFPDQGRYECVARN 584
            + + + C A+G P P ++W+ EG+ + ES +  ++ +G+ L +   G    G Y CVA +
Sbjct: 1612 RPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASS 1671

Query: 585  SFGLAV 590
              G AV
Sbjct: 1672 PAGEAV 1677



 Score =  144 bits (363), Expect = 6e-34
 Identities = 105/365 (28%), Positives = 155/365 (42%), Gaps = 17/365 (4%)

Query: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM 291
           ++P+++          G  V  +C A G P P I W  +  S  L++D+R++V   GTL+
Sbjct: 606 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW--SRESQALQEDSRIHVDAQGTLI 663

Query: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351
           I+     D G Y C A N  G    Q  +  Y + P  PS         V +G    L C
Sbjct: 664 IQGVAPEDAGNYSCQATNEVGT--DQETVTLYYTDP--PSVSAVNAVVLVAVGEEAVLVC 719

Query: 352 MATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAA 411
            A+G P P + W R  GLE+  +   ++S  L +    +RD G +TC A N  G   A  
Sbjct: 720 EASGVPPPRVIWYR-GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEI 778

Query: 412 NIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EG 463
            + V   PQ T  P+D  V    +    C A G PPP + W +  GQ P+          
Sbjct: 779 QLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGAGRGS 837

Query: 464 QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVE 523
           +     SG L  +  A  DQ  Y C+A +  G  +   +L V   A            V 
Sbjct: 838 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 897

Query: 524 VGKNINISCHA-QGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVA 582
            G+ +++ C    G P P   W K+G  +    +  +  +G+L +  A     GRY CVA
Sbjct: 898 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA 957

Query: 583 RNSFG 587
            N+ G
Sbjct: 958 TNTAG 962



 Score =  137 bits (346), Expect = 6e-32
 Identities = 105/371 (28%), Positives = 152/371 (40%), Gaps = 28/371 (7%)

Query: 243  VEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGV 302
            +E  +G      C A G PKP++ W     S  L     + V ++G+L + +   +D G 
Sbjct: 1216 LERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGD 1275

Query: 303  YQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEV--LIGTSTTLECMATGHPHPL 360
            Y+C A N  G    ++ ++ Y      PS     +   V  + G S TLEC A G P P 
Sbjct: 1276 YECQATNEVGSTSRRAKLVVY----VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE 1331

Query: 361  ITWTRDNGL-----------------ELDGSRHVATSSGLYLQNITQRDHGRFTCHANNS 403
            I W +D  L                 ++ G R +     L+   I + D G ++C A N 
Sbjct: 1332 IVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQ 1391

Query: 404  HGTVQAAANIIVQAPPQFTVTPKDQVV--LEEHAVEWLCEADGNPPPVIVWTKTGGQLPV 461
             GT Q   +++V  PP        Q V  L    VE  C   G P P + WTK    +  
Sbjct: 1392 AGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP 1451

Query: 462  EGQHTVLSSG--TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQD 519
             G H  +      LRI  +   D+G+Y+C A S  G +    QL V        +    +
Sbjct: 1452 GGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGE 1511

Query: 520  TSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRY 578
             +V     + + C A+G P P ITW K+G  +  S K      G  L +  A   D G Y
Sbjct: 1512 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVY 1571

Query: 579  ECVARNSFGLA 589
             C A N+ G A
Sbjct: 1572 TCKASNAVGAA 1582



 Score =  137 bits (346), Expect = 6e-32
 Identities = 110/355 (30%), Positives = 158/355 (44%), Gaps = 29/355 (8%)

Query: 245  VPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVF-DDGTLMIRNTRESDQGVY 303
            V  G  V   C A+G P P++ W+ +   L  +    L  + D G+L+++  R SD G Y
Sbjct: 3229 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 3288

Query: 304  QCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLI---GTSTTLECMATGHPHPL 360
             C+A N AGE     A L   ++   P+       +  L+   G   T+ C   G P   
Sbjct: 3289 TCVAHNPAGE----DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH 3344

Query: 361  ITWTRDNGLELDGS-RHVATSSG--LYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
            ++W +D GL L  S R +   SG  L +  +   D G FTC A +  G       + VQ 
Sbjct: 3345 VSWLKD-GLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV 3403

Query: 418  PPQFTVTP--KDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG-TLR 474
            PP         D VV+    VE  CEA G P P++ W K G  L  +     L  G +L+
Sbjct: 3404 PPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS----LEQGPSLQ 3459

Query: 475  IDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHA 534
            ++     D G Y C AVS  G  +   QLTV        +  P + S+  G  + + C A
Sbjct: 3460 LEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDA 3519

Query: 535  QGEPQPIITWNKEGVQITESGKFHVDDEGT--LTIYDAGFPDQGRYECVARNSFG 587
            QG PQP ITW+K+G  +T   +   +   T  L + DAG      Y C+A +  G
Sbjct: 3520 QGTPQPNITWHKDGQALT---RLENNSRATRVLRVRDAGL-----YTCLAESPAG 3566



 Score =  135 bits (340), Expect = 3e-31
 Identities = 112/369 (30%), Positives = 160/369 (43%), Gaps = 24/369 (6%)

Query: 244  EVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMIRNTRESDQGV 302
            E+   N  Y  C     P P++ W   +  L   D+  ++V   G  L I   R  + G 
Sbjct: 2761 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE--VSVLQGGRVLQIPLVRAENAGR 2818

Query: 303  YQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDT---EVLIGTSTT--LECMATGHP 357
            Y C A N  GE       L Y  L   P  ++   +    EV +  S+T  L+C A G+P
Sbjct: 2819 YSCKASNEVGED-----WLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNP 2873

Query: 358  HPLITWTRDNGLELDGS-RHVATSSGLYLQNITQR--DHGRFTCHANNSHGTVQAAANII 414
             P I+W + NGL    S R      G  LQ  T    D   + C A N  G+ +    + 
Sbjct: 2874 VPTISWLQ-NGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLR 2932

Query: 415  VQAPPQFTVTPKDQVV-LEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGT- 472
            VQ PP+      +QV  +   +V   C+   +P P + W K    L + G+   L  GT 
Sbjct: 2933 VQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSL-GEEVFLLPGTH 2991

Query: 473  -LRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKALAVFTQLPQD-TSVEVGKNIN 529
             L++ RA   D G Y C+A+++ G  +  VQL+V  P A     + PQD   V VG    
Sbjct: 2992 TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAV 3051

Query: 530  ISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFGL 588
            +SC     P+P +TW K+G  +  + +      G  L I +A   D+G Y C   N  G 
Sbjct: 3052 LSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 3111

Query: 589  AVTNMFLTV 597
            AV    LTV
Sbjct: 3112 AVRTFTLTV 3120



 Score =  135 bits (339), Expect = 4e-31
 Identities = 108/378 (28%), Positives = 160/378 (42%), Gaps = 31/378 (8%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM-IRNTRE 297
            E   + V  G+    +C   G P P+I W  +   L  E     +V   G L+ +   + 
Sbjct: 2168 ESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQL 2227

Query: 298  SDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHP 357
            + +G Y C   N  G + +Q   L     P        P    V+     TLEC ATG P
Sbjct: 2228 AQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP 2286

Query: 358  HPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDH---------GRFTCHANNSHGTVQ 408
             P +TW RD        + V    GL LQN  Q  H         GR++C A N  G  +
Sbjct: 2287 PPTVTWERD-------GQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAE 2339

Query: 409  AAANIIVQAPPQF--TVTPKDQVVLEEHA-VEWLCEADGNPPPVIVWTKTGGQLPVE-GQ 464
                + V  PP+    + P   +    H+ +  LCEA G PPP I W +  G+ PV  G+
Sbjct: 2340 RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGE 2397

Query: 465  HTVLSSG--TLRIDRAAQHDQGQYECQAVSSLGV--KKVSVQLTVKPKALAVFTQLPQDT 520
             T L +G   L++ +  + D G Y C A +  G   +  SV++ V P        L +  
Sbjct: 2398 DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS--IENEDLEEVI 2455

Query: 521  SVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGT-LTIYDAGFPDQGRYE 579
             V  G+  ++ C+  G PQP +TW K+G  +      H+  +G  L +  A     G Y 
Sbjct: 2456 KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYS 2515

Query: 580  CVARNSFGLAVTNMFLTV 597
            C+A N+ G    +  L+V
Sbjct: 2516 CIAANAVGEKTKHFQLSV 2533



 Score =  134 bits (338), Expect = 5e-31
 Identities = 108/353 (30%), Positives = 152/353 (43%), Gaps = 29/353 (8%)

Query: 255  CRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEA 314
            C A G P P I W      +   +DT L +     L +  T+E D G+Y C+A N AGEA
Sbjct: 2374 CEAMGIPPPAIRWFRGEEPVSPGEDTYL-LAGGWMLKMTQTQEQDSGLYSCLASNEAGEA 2432

Query: 315  KTQSAMLRYSSLPAKPSFVIQPQDTE----VLIGTSTTLECMATGHPHPLITWTRDNGLE 370
            +   ++     +   PS  I+ +D E    VL G +  L C  TGHP P +TW +D    
Sbjct: 2433 RRNFSV----EVLVPPS--IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 2486

Query: 371  LDGSRHVATSSGLYLQNITQR--DHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQ 428
              G  H  +  G+ LQ +       G ++C A N+ G       + V   P      +D 
Sbjct: 2487 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDS 2546

Query: 429  -----VVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV-LSSGT--LRIDRAAQ 480
                  V   + +  +CEA   P P I W K G   P E    + L  GT  L+I  A +
Sbjct: 2547 ADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--PFEASRNIQLLPGTHGLQILNAQK 2604

Query: 481  HDQGQYECQAVSSLG--VKKVSVQLTVKP---KALAVFTQLPQDTSVEVGKNINISCHAQ 535
             D GQY C   + LG  VK   V++ + P   K   +     ++   +V   + + C + 
Sbjct: 2605 EDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW 2664

Query: 536  GEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFG 587
              P P I W K+G  +T S +  V  EG  L I      D GRY CVA N  G
Sbjct: 2665 AVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 2717



 Score =  133 bits (335), Expect = 1e-30
 Identities = 100/362 (27%), Positives = 159/362 (43%), Gaps = 28/362 (7%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
            +P ++ +  G  +   C A+G P+P I W  +  +L     TRL   ++ +   R  R  
Sbjct: 3501 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-----TRL---ENNSRATRVLRVR 3552

Query: 299  DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTS---TTLECMATG 355
            D G+Y C+A + AG A  +S  +R  +    P  ++ P+    ++G +     LEC    
Sbjct: 3553 DAGLYTCLAESPAG-AIEKSFRVRVQA----PPNIVGPRGPRFVVGLAPGQLVLECSVEA 3607

Query: 356  HPHPLITWTRDNGLELDGSRHV---ATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAAN 412
             P P ITW RD G+ L    H         L LQ ++  D G ++C A N+ G+   A  
Sbjct: 3608 EPAPKITWHRD-GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666

Query: 413  IIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL-PVEGQHTVLSSG 471
            + +   P     P    V         C+ADG P P++ W K    L P   +  +L  G
Sbjct: 3667 VEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG 3726

Query: 472  TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKALAVFTQLPQDTSVEVGKNINI 530
            +LRI      D G Y C A +S G  +    L V +P A+A     P + ++       +
Sbjct: 3727 SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIA---PSPSNLTLTAHTPALL 3783

Query: 531  SCHAQGEPQPIITWNKEGVQI---TESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
             C A G P+P++ W K+G ++    + G + +     L +   G  D  ++ECV  N  G
Sbjct: 3784 PCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG 3843

Query: 588  LA 589
             A
Sbjct: 3844 EA 3845



 Score =  130 bits (326), Expect = 1e-29
 Identities = 109/375 (29%), Positives = 159/375 (42%), Gaps = 19/375 (5%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P I   P +  V    +V   C A G P P++ W   +  +       ++V D   L I 
Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV-DGRVLRIE 1944

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE--VLIGTSTTLEC 351
              + SD G Y+C+A N AG     S  LRY      P  +  P      VL+ T   L C
Sbjct: 1945 QAQLSDAGSYRCVASNVAG-----STELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTC 1999

Query: 352  MATGHPHPLITWTRD-NGLELDGSRHVATSSG---LYLQNITQRDHGRFTCHANNSHGTV 407
             ATG P P + W +D N +   G+  +    G   L L +    D GR++C A ++ G  
Sbjct: 2000 NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 2059

Query: 408  QAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL-PVEGQHT 466
            +    + V  PP       +  V+   +V   C++   PPPV+ W K G  L P  G H 
Sbjct: 2060 RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL 2119

Query: 467  VLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDT-SVEVG 525
                  L++DRA   D G Y C+A++  G  +    L V      VF      T +V  G
Sbjct: 2120 SADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV--WVAPVFPLRESHTLTVREG 2177

Query: 526  KNINISCHAQGEPQPIITWNKEGVQI--TESGKFHVDDEGTLT-IYDAGFPDQGRYECVA 582
               ++SC  +G P P I+W K+G  +    +G  HV   G L  +  A    +G Y C  
Sbjct: 2178 HPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC 2237

Query: 583  RNSFGLAVTNMFLTV 597
             N  G +  ++ L V
Sbjct: 2238 SNVVGNSSQDLQLEV 2252



 Score =  129 bits (324), Expect = 2e-29
 Identities = 116/470 (24%), Positives = 192/470 (40%), Gaps = 52/470 (11%)

Query: 241  QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ 300
            ++V V   N +   C A   P P I W+ +    +   + +L     G L I N ++ D 
Sbjct: 2549 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDA 2607

Query: 301  GVYQCMARNSAGEAKTQ---SAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHP 357
            G Y C+  N  GEA        ++  S     P   +  ++ +  + ++ TLEC +   P
Sbjct: 2608 GQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVP 2667

Query: 358  HPLITWTRDNGLELDGSRHVATSSG--LYLQNITQRDHGRFTCHANNSHGTVQAAANIIV 415
             P I W +D       SR      G  L +Q     D GR+ C A N  G      N+++
Sbjct: 2668 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 2727

Query: 416  QAPPQFT---------------------VTPKDQVVLEEHAVEWLCEADGNPPPVIVWTK 454
            Q PP F                      VT   ++V E +     C+ +  PPP + W +
Sbjct: 2728 QVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV-ENNPAYLYCDTNAIPPPDLTWYR 2786

Query: 455  TGGQLPVEGQHTVLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV--KPKALA 511
                L    + +VL  G  L+I      + G+Y C+A + +G   +  +L V   P  L 
Sbjct: 2787 EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILG 2846

Query: 512  VFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDA 570
               +L ++ +V     +++ C A G P P I+W + G+  + S +  V ++G  L +  A
Sbjct: 2847 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTA 2906

Query: 571  GFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRR 630
               D   Y CVA N  G A   +F     +  R AG D         +++V + +NS+  
Sbjct: 2907 EVADAASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLD---------LEQVTAILNSSVS 2956

Query: 631  HLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIF----EHTLQLIRERV 676
                   H + ++     + +D   + +    E+F     HTLQL R R+
Sbjct: 2957 LPCDVHAHPNPEVT----WYKDSQALSLGE--EVFLLPGTHTLQLGRARL 3000



 Score =  128 bits (322), Expect = 4e-29
 Identities = 108/398 (27%), Positives = 169/398 (42%), Gaps = 31/398 (7%)

Query: 234  PRIT-FEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMI 292
            PRI   + + V     ++V   C    +P PE+ W  ++ +L L ++  L +    TL +
Sbjct: 2937 PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFL-LPGTHTLQL 2995

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE----VLIGTSTT 348
               R SD G+Y C A N+AG    +   L   S+   P+F   P+  +    V +G    
Sbjct: 2996 GRARLSDSGMYTCEALNAAG----RDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAV 3051

Query: 349  LECMATGHPHPLITWTRDNGLELDGSRHVATSSG--LYLQNITQRDHGRFTCHANNSHGT 406
            L C     P P +TW +D    +   R  A   G  L +Q     D G ++C  +N  G 
Sbjct: 3052 LSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 3111

Query: 407  VQAAANIIVQAPPQFTVTPKDQVV--LEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQ 464
                  + VQ PP F   PK + V  +    +   C+  G P P + W K   ++PVE  
Sbjct: 3112 AVRTFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK--DRMPVESS 3168

Query: 465  --HTVLS-SGTLRIDRAAQHDQGQYECQAVSSLGV--KKVSVQLTVKPKALAVFTQLPQD 519
              H V+S  G L++ R      G Y C A ++     K   V + V P+  +  + + ++
Sbjct: 3169 AVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS--SGVARE 3226

Query: 520  TSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVD---DEGTLTIYDAGFPDQG 576
              V  G+ + + C A G+P P + W K+G  + +    H+    D G+L +      D G
Sbjct: 3227 HHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAG 3286

Query: 577  RYECVARNSFG----LAVTNMFLTVTAIQGRQAGDDFV 610
             Y CVA N  G    L   N+ +  T  QG       V
Sbjct: 3287 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLV 3324



 Score =  125 bits (315), Expect = 2e-28
 Identities = 100/372 (26%), Positives = 153/372 (41%), Gaps = 17/372 (4%)

Query: 237  TFEPQDVEVPS---GNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            TFE    E  S   G+ +  TC   G P P + W+ +   ++        V   G L + 
Sbjct: 3125 TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVE-SSAVHGVVSRGGRLQLS 3183

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMA 353
              + +  G Y C+A N+  EA+    +    +   + S V +  +  VL G    L+C A
Sbjct: 3184 RLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAR--EHHVLEGQEVRLDCEA 3241

Query: 354  TGHPHPLITWTRDNG-LELDGSRHVA---TSSGLYLQNITQRDHGRFTCHANNSHGTVQA 409
             G P P + W +D   L  D   H+        L L+ +   D G +TC A+N  G    
Sbjct: 3242 DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDAR 3301

Query: 410  AANIIVQAPPQFTVTPKDQVVLEEHA---VEWLCEADGNPPPVIVWTKTGGQLPVEGQHT 466
               + V  PP           L       V  +C   G+PP  + W K G  LP+  +  
Sbjct: 3302 LHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTL 3361

Query: 467  VLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVG 525
            +  SG TLRI +    D G + C A S  GV   +  L V+   +    +   D  V  G
Sbjct: 3362 LHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRG 3421

Query: 526  KNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + + C A+G P P+++W K+G  +       ++   +L +   G  D G Y CVA + 
Sbjct: 3422 SLVELPCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSE 3478

Query: 586  FGLAVTNMFLTV 597
             G A  +  LTV
Sbjct: 3479 AGEARRHFQLTV 3490



 Score =  124 bits (311), Expect = 7e-28
 Identities = 104/389 (26%), Positives = 159/389 (40%), Gaps = 32/389 (8%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P++   P+ ++V  G  +   C AEGNP+P++ W  +   L             G++   
Sbjct: 1120 PQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG-------PQGSVHFA 1172

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMA 353
              R SD G Y+C A NSAG        LR    P   +        E + G + +L C A
Sbjct: 1173 AIRTSDAGRYRCEASNSAG-VDAWEVELRVLEPPHWGADETSGL-LERVAGENASLPCPA 1230

Query: 354  TGHPHPLITWTRDNGLE-LDGSRHVAT--SSGLYLQNITQRDHGRFTCHANNSHGTVQAA 410
             G P P +TW +    E L G   VA      L+L +++  D G + C A N  G+    
Sbjct: 1231 RGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRR 1290

Query: 411  ANIIVQAPPQFTVTPKDQVV--LEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE------ 462
            A ++V  PP      +   V  +   ++   C+A+G P P IVW K    + V       
Sbjct: 1291 AKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGY 1350

Query: 463  ---------GQHTVLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAV 512
                     G H +L  G +L   R  + D G Y C+A +  G  +    L V      +
Sbjct: 1351 GWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVL 1410

Query: 513  FTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESG-KFHVDDEG-TLTIYDA 570
                 Q+     G ++ + C   G P P + W K+   +   G    V ++G  L I  +
Sbjct: 1411 GAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGS 1470

Query: 571  GFPDQGRYECVARNSFGLAVTNMFLTVTA 599
               D+GRY+CVA +  G    +  L V A
Sbjct: 1471 HVGDEGRYQCVAFSPAGQQARDFQLRVHA 1499



 Score =  120 bits (301), Expect = 1e-26
 Identities = 108/369 (29%), Positives = 163/369 (44%), Gaps = 19/369 (5%)

Query: 241  QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMIRNTRESD 299
            Q+V   +G  V   C   G P P++ W  +   + L     L V +DG  L I  +   D
Sbjct: 1416 QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGD 1474

Query: 300  QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLE--CMATGHP 357
            +G YQC+A + AG+ + +   LR   + A P+     +  EV +     ++  C A G P
Sbjct: 1475 EGRYQCVAFSPAGQ-QARDFQLR---VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 1530

Query: 358  HPLITWTRDNGLELDGSRHVATSSGLYLQ--NITQRDHGRFTCHANNSHGTVQAAANIIV 415
             P ITW +D  L    ++ V T  G  LQ       D G +TC A+N+ G  + A  + V
Sbjct: 1531 TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 1590

Query: 416  QAPPQFTVTPKDQVVLEEHA---VEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGT 472
              PP          V++  A   V   C A G+P P + W   G  +    +  + + G+
Sbjct: 1591 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS 1650

Query: 473  -LRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNIN 529
             LR++   +   G Y C A S  G  V + SV++ V P+ L V   L Q T++ VG+ + 
Sbjct: 1651 VLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLL-VAEGLGQVTTI-VGQPLE 1708

Query: 530  ISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFGL 588
            + C A G P P I W + G    E     V  +G TL I        G + C A N  G 
Sbjct: 1709 LPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGT 1768

Query: 589  AVTNMFLTV 597
            A   + ++V
Sbjct: 1769 AGAEVEVSV 1777



 Score =  119 bits (299), Expect = 2e-26
 Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 13/305 (4%)

Query: 290  LMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTL 349
            L I      D+G+Y C A N AGE+K + A+     +   P+    P +  VL   S TL
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVAL----KVLVPPNIEPGPVNKAVLENASVTL 1905

Query: 350  ECMATGHPHPLITWTRDNGLELDGSRHVATSSG--LYLQNITQRDHGRFTCHANNSHGTV 407
            EC+A+G P P ++W + +           +  G  L ++     D G + C A+N  G+ 
Sbjct: 1906 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 1965

Query: 408  QAAANIIVQAPPQFTVTPK-DQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLP---VEG 463
            +    + V  PP+ T+ P     VL    V   C A G P P ++W K G  +      G
Sbjct: 1966 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 2025

Query: 464  QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVE 523
                     L +  A   D G+Y C AVS++G  +  V L V      +  +L  + SV 
Sbjct: 2026 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEEL--NVSVV 2083

Query: 524  VGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVD-DEGTLTIYDAGFPDQGRYECVA 582
              +++ + C +   P P+++W K+G  +      H+  D+  L +  A   D G Y C A
Sbjct: 2084 ANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA 2143

Query: 583  RNSFG 587
             N  G
Sbjct: 2144 LNQAG 2148



 Score =  119 bits (297), Expect = 3e-26
 Identities = 96/374 (25%), Positives = 158/374 (42%), Gaps = 22/374 (5%)

Query: 248  GNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMA 307
            G  V   C   G+P   + W+ +   L L   T L+     TL I   + +D G++ C+A
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHG-SGHTLRISKVQLADAGIFTCVA 3386

Query: 308  RNSAGEAKTQSAMLRYSSLPAKPSFVIQP----QDTEVLIGTSTTLECMATGHPHPLITW 363
             + AG A       R  +L  +   V++P     D  V+ G+   L C A G P PL++W
Sbjct: 3387 ASPAGVAD------RNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW 3440

Query: 364  TRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTV 423
             +D    L  S+ +     L L+ +   D G ++C A +  G  +    + V  PP    
Sbjct: 3441 MKDGEPLL--SQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIED 3498

Query: 424  T--PKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQH 481
            +  P +  +     +E LC+A G P P I W K G  L    ++   ++  LR+      
Sbjct: 3499 SGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-TRLENNSRATRVLRV-----R 3552

Query: 482  DQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPI 541
            D G Y C A S  G  + S ++ V+     V  + P+         + + C  + EP P 
Sbjct: 3553 DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPK 3612

Query: 542  ITWNKEGVQITESGKFHVDDEGT-LTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAI 600
            ITW+++G+ + E       + G  L +      D G Y C ARN+ G       + +  +
Sbjct: 3613 ITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV 3672

Query: 601  QGRQAGDDFVESSI 614
               ++G   V  S+
Sbjct: 3673 PTIRSGPPAVNVSV 3686



 Score =  116 bits (291), Expect = 1e-25
 Identities = 85/279 (30%), Positives = 123/279 (44%), Gaps = 17/279 (6%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMI 292
            P  T  P D  +  G+ ++  C A G+P P I W  N+  +       ++  D G TL  
Sbjct: 4129 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQR 4184

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLI---GTSTTL 349
                  D G Y C A N  G  +TQ+     S +  K + V+Q +    L+   G S  L
Sbjct: 4185 AAVSREDSGTYVCWAENRVG--RTQAV----SFVHVKEAPVLQGEAFSYLVEPVGGSIQL 4238

Query: 350  ECMATGHPHPLITWTRDNGLELDGS--RHVATSSGLYLQNITQRDHGRFTCHANNSHGTV 407
            +C+  G P P I W +D GL L GS  RH   +  L +    + D GR+ C A N  G  
Sbjct: 4239 DCVVRGDPVPDIHWIKD-GLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVA 4297

Query: 408  QAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV 467
            +    +++Q+ P F V P+D  V     V   C+A G P P I W + G  L    +   
Sbjct: 4298 KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 4357

Query: 468  LSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVK 506
            L  G+L ++     D G Y+C A + LG       L V+
Sbjct: 4358 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396



 Score =  115 bits (288), Expect = 3e-25
 Identities = 95/331 (28%), Positives = 139/331 (41%), Gaps = 30/331 (9%)

Query: 288  GTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTST 347
            G+L +   +  D G Y+C A N AG A  +  +     +   P     P+  +VL+G + 
Sbjct: 1082 GSLRLAQVQVGDSGHYECTASNPAGSASHRYVL----GVQVPPQVQPGPRVLKVLVGEAL 1137

Query: 348  TLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTV 407
             L C+A G+P P ++W++D G+ L G         ++   I   D GR+ C A+NS G  
Sbjct: 1138 DLNCVAEGNPEPQLSWSKD-GVVLQGR---GPQGSVHFAAIRTSDAGRYRCEASNSAGVD 1193

Query: 408  QAAANIIVQAPPQFTVTPKDQVVLEEHAVE---WLCEADGNPPPVIVWTKTGGQLPVEGQ 464
                 + V  PP +    +   +LE  A E     C A G P P + W K     P+ GQ
Sbjct: 1194 AWEVELRVLEPPHWG-ADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQ 1252

Query: 465  H--TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV 522
                VL  G+L +   +  D G YECQA + +G      +L V             + S 
Sbjct: 1253 PGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSG 1312

Query: 523  EVGKNINISCHAQGEPQPIITWNKE----GVQITESG---KFHVDDEGTLTIYDAG---- 571
              G+++ + C A G P P I W K+    GV +  +G          G   + D G    
Sbjct: 1313 MAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLH 1372

Query: 572  FP-----DQGRYECVARNSFGLAVTNMFLTV 597
            FP     D G Y C A N  G A  +  L V
Sbjct: 1373 FPRIQEGDSGLYSCRAENQAGTAQRDFHLLV 1403



 Score =  114 bits (285), Expect = 7e-25
 Identities = 86/310 (27%), Positives = 140/310 (45%), Gaps = 14/310 (4%)

Query: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351
           I    ++++G Y+C A + AG  + ++ ++    +   P  ++   +  V  G +  L C
Sbjct: 483 ILRASKAEEGTYECTAVSRAGTGRAKAQIV----VTDPPPQLVPAPNVTVSPGETAVLSC 538

Query: 352 MATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQ--NITQRDHGRFTCHANNSHGTVQA 409
              G     +TW RD  +    +  VA  + L L+   I   D GR+ C A+N++G  +A
Sbjct: 539 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 598

Query: 410 AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLS 469
           +  ++V+  PQ ++    Q   +   V+  C A G P P I W++    L  + +  V +
Sbjct: 599 SVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 658

Query: 470 SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQL--TVKPKALAVFTQLPQDTSVEVGKN 527
            GTL I   A  D G Y CQA + +G  + +V L  T  P   AV   +     V VG+ 
Sbjct: 659 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV----LVAVGEE 714

Query: 528 INISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
             + C A G P P + W + G+++  + +      G L I  A   D G Y C A N  G
Sbjct: 715 AVLVCEASGVPPPRVIWYRGGLEMILAPE--GSSSGKLRIPAAQERDAGTYTCRAVNELG 772

Query: 588 LAVTNMFLTV 597
            A   + L V
Sbjct: 773 DASAEIQLAV 782



 Score =  105 bits (263), Expect = 2e-22
 Identities = 102/387 (26%), Positives = 143/387 (36%), Gaps = 68/387 (17%)

Query: 203  HTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPK 262
            H       + P R+H  A   +T E      P                    C A G P 
Sbjct: 965  HRDVELVVQVPPRIHPTATHHITNEGVPASLP--------------------CVASGVPA 1004

Query: 263  PEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLR 322
            P I W    ++L        NV  +GTL+I      D G Y C A N+ G + +Q   L 
Sbjct: 1005 PTITWTKETNALTSRGP-HYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS-SQEMRLS 1062

Query: 323  YSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSG 382
             + L A   +V                             W  + GL   GS        
Sbjct: 1063 VNRL-ALSKYV-----------------------------W-EEYGLLPSGS-------- 1083

Query: 383  LYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEA 442
            L L  +   D G + C A+N  G+      + VQ PPQ    P+   VL   A++  C A
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVA 1143

Query: 443  DGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQ 502
            +GNP P + W+K G  L   G       G++        D G+Y C+A +S GV    V+
Sbjct: 1144 EGNPEPQLSWSKDGVVLQGRG-----PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVE 1198

Query: 503  LTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGK--FHVD 560
            L V         +         G+N ++ C A+G P+P +TW K        G+    V 
Sbjct: 1199 LRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVL 1258

Query: 561  DEGTLTIYDAGFPDQGRYECVARNSFG 587
            +EG+L +      D G YEC A N  G
Sbjct: 1259 EEGSLFLASVSPADSGDYECQATNEVG 1285



 Score =  105 bits (263), Expect = 2e-22
 Identities = 99/374 (26%), Positives = 156/374 (41%), Gaps = 39/374 (10%)

Query: 240  PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299
            P  V+  +G  V   C A G+P P + W H    +   +++RL   D   L + +  E+ 
Sbjct: 1603 PYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET-DGSVLRLESPGEAS 1661

Query: 300  QGVYQCMARNSAGEAKTQSAMLRYS-SLPAKPSFVIQPQDTEV--LIGTSTTLECMATGH 356
             G+Y C+A + AGE     A+L+YS  +   P  ++     +V  ++G    L C A+G 
Sbjct: 1662 SGLYSCVASSPAGE-----AVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGS 1716

Query: 357  PHPLITWTRDN--GLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANII 414
            P P I W ++     EL G +  +  + L++ ++     G F C A N  GT  A   + 
Sbjct: 1717 PVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVS 1776

Query: 415  VQ---APPQFTVTPKDQVVLEEHAVEW--LCE--------ADGNPPPVIVWTKTGGQLPV 461
            V    AP    V         EH   +   C+        A   PP V  W   G    +
Sbjct: 1777 VHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS---L 1833

Query: 462  EGQHTVLSSG-----TLRIDRAAQHDQGQYECQAVSSLGVKK--VSVQLTVKPKALAVFT 514
             G+ T +         L+I++    D+G Y C A +  G  K  V++++ V P       
Sbjct: 1834 WGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN----IE 1889

Query: 515  QLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFP 573
              P + +V    ++ + C A G P P ++W K    ++      V  +G  L I  A   
Sbjct: 1890 PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLS 1949

Query: 574  DQGRYECVARNSFG 587
            D G Y CVA N  G
Sbjct: 1950 DAGSYRCVASNVAG 1963



 Score =  101 bits (252), Expect = 5e-21
 Identities = 79/275 (28%), Positives = 116/275 (42%), Gaps = 13/275 (4%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG--TLMIRNTR 296
            E  +V V   + V   C A G P P I W  +   L         V+  G   L +   +
Sbjct: 1508 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKV---VYTRGGRQLQLGRAQ 1564

Query: 297  ESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGH 356
             SD GVY C A N+ G A+  + +  Y   P       +P   + + G    LEC+A GH
Sbjct: 1565 SSDAGVYTCKASNAVGAAEKATRLDVYVP-PTIEGAGGRPYVVKAVAGRPVALECVARGH 1623

Query: 357  PHPLITWTRDNGL---ELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANI 413
            P P ++W  + GL   E + SR     S L L++  +   G ++C A++  G      ++
Sbjct: 1624 PSPTLSWHHE-GLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSV 1682

Query: 414  IVQAPPQFTVTP--KDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG 471
             VQ PPQ  V         +    +E  C+A G+P P I W + G          V S G
Sbjct: 1683 EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG 1742

Query: 472  -TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
             TL ID       G + CQA +  G     V+++V
Sbjct: 1743 TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 1777



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 31/89 (34%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 233  SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMI 292
            +P    EPQD+ V SG+ V   C+A G P P I W+       L    RL    DG+L +
Sbjct: 4308 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQ--PLRASRRLRTLPDGSLWL 4365

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAML 321
             N    D G Y C+A N  G A  ++ ++
Sbjct: 4366 ENVETGDAGTYDCVAHNLLGSATARAFLV 4394


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score =  174 bits (442), Expect = 4e-43
 Identities = 124/385 (32%), Positives = 168/385 (43%), Gaps = 22/385 (5%)

Query: 225 TVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNV 284
           TV  +    P ++     V V  G      C A G P P +IW      + L  +     
Sbjct: 572 TVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--- 628

Query: 285 FDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIG 344
              G L I   +E D G Y C A N  G+A  +  +    ++   P     P+D  V +G
Sbjct: 629 -SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL----AVGHAPQLTELPRDVTVELG 683

Query: 345 TSTTLECMATGHPHPLITWTRDNGLELD-------GSRHVATSSG-LYLQNITQRDHGRF 396
            S  L C ATG P P +TW R +G  L        GSR     SG L+ +++   D   +
Sbjct: 684 RSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 743

Query: 397 TCHANNSHGTVQAAANIIV--QAPPQFTVTPKDQVVLEEHAVEWLC-EADGNPPPVIVWT 453
            C A N  G VQA A +IV   APPQ   +     VLE   V   C    G P P   W 
Sbjct: 744 VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWL 803

Query: 454 KTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVF 513
           K G  LP   +H++ + G+L +DRA Q   G+Y C A ++ G +   V+L V+       
Sbjct: 804 KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHP 863

Query: 514 TQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESG-KFHVDDEGTLTIYDAGF 572
           T     T+   G   ++ C A G P P ITW KE   +T  G  ++V  EGTL I     
Sbjct: 864 TATHHITN--EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSA 921

Query: 573 PDQGRYECVARNSFGLAVTNMFLTV 597
            D G Y C A N+ G +   M L+V
Sbjct: 922 QDAGAYVCTATNTVGFSSQEMRLSV 946



 Score =  167 bits (424), Expect = 5e-41
 Identities = 112/396 (28%), Positives = 168/396 (42%), Gaps = 19/396 (4%)

Query: 222  ASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHS-----LDL 276
            AS  ++     +P++T  P+DV V  G +    CRA G P P + W   +       L  
Sbjct: 657  ASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGA 716

Query: 277  EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQP 336
               +R    D G L   +    DQ  Y C ARN  G+ + ++ ++     P  P      
Sbjct: 717  GRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP--PQIASSA 774

Query: 337  QDTEVLIGTSTTLECMA-TGHPHPLITWTRDNGLELDGSRHVATSSG-LYLQNITQRDHG 394
                VL G   +L C+   G P P   W +D      GSRH   + G L+L    Q   G
Sbjct: 775  PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAG 834

Query: 395  RFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTK 454
            R++C A N+ G+      ++VQ PP+   T    +  E       C A G P P I WTK
Sbjct: 835  RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTK 894

Query: 455  TGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVF 513
                L   G H  V   GTL I + +  D G Y C A +++G     ++L+V  K     
Sbjct: 895  ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHM 954

Query: 514  -----TQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITE-SGKFHVDDEGTLTI 567
                   +P   + + G+ + + C A+G P P++TW K+   +   + ++ +   G+L +
Sbjct: 955  NGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRL 1014

Query: 568  YDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGR 603
                  D G YEC A N  G A       V  +QGR
Sbjct: 1015 AQVQVGDSGHYECTASNPAGSASHRY---VLGVQGR 1047



 Score =  164 bits (416), Expect = 4e-40
 Identities = 114/389 (29%), Positives = 170/389 (43%), Gaps = 21/389 (5%)

Query: 218 GRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE 277
           GRA A + V +     P++   P +V V  G T   +CR  G     + W+ +   L   
Sbjct: 388 GRAKAQIVVTD---PPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 443

Query: 278 DDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQ 337
              R+    D +L I     +D G YQC+A N+ G  +    +L    +   P   I   
Sbjct: 444 TG-RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL----VREAPQVSIHTS 498

Query: 338 DTEVLIGTSTTLECMATGHPHPLITWTRDN-GLELDGSRHVATSSGLYLQNITQRDHGRF 396
                 G    + C A+G+P P I+W+R++  L+ D   HV     L +Q +   D G +
Sbjct: 499 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 558

Query: 397 TCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTG 456
           +C A N  GT Q    +    PP  +      +V        +CEA G PPP ++W + G
Sbjct: 559 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 618

Query: 457 GQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQL 516
            ++ +  + +  SSG LRI  A + D G Y C+AV+ LG     +QL V        T+L
Sbjct: 619 LEMILAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV--GHAPQLTEL 674

Query: 517 PQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQ-------ITESGKFHVDDEGTLTIYD 569
           P+D +VE+G++  ++C A G P P +TW +   Q            +    D G L    
Sbjct: 675 PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFES 734

Query: 570 AGFPDQGRYECVARNSFGLAVTNMFLTVT 598
               DQ  Y C ARN FG       L VT
Sbjct: 735 VAPEDQAPYVCEARNVFGKVQAEARLIVT 763



 Score =  144 bits (363), Expect = 6e-34
 Identities = 105/365 (28%), Positives = 155/365 (42%), Gaps = 17/365 (4%)

Query: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM 291
           ++P+++          G  V  +C A G P P I W  +  S  L++D+R++V   GTL+
Sbjct: 489 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW--SRESQALQEDSRIHVDAQGTLI 546

Query: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351
           I+     D G Y C A N  G    Q  +  Y + P  PS         V +G    L C
Sbjct: 547 IQGVAPEDAGNYSCQATNEVGT--DQETVTLYYTDP--PSVSAVNAVVLVAVGEEAVLVC 602

Query: 352 MATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAA 411
            A+G P P + W R  GLE+  +   ++S  L +    +RD G +TC A N  G   A  
Sbjct: 603 EASGVPPPRVIWYR-GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEI 661

Query: 412 NIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EG 463
            + V   PQ T  P+D  V    +    C A G PPP + W +  GQ P+          
Sbjct: 662 QLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGAGRGS 720

Query: 464 QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVE 523
           +     SG L  +  A  DQ  Y C+A +  G  +   +L V   A            V 
Sbjct: 721 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 780

Query: 524 VGKNINISCHA-QGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVA 582
            G+ +++ C    G P P   W K+G  +    +  +  +G+L +  A     GRY CVA
Sbjct: 781 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA 840

Query: 583 RNSFG 587
            N+ G
Sbjct: 841 TNTAG 845



 Score =  114 bits (285), Expect = 7e-25
 Identities = 86/310 (27%), Positives = 140/310 (45%), Gaps = 14/310 (4%)

Query: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351
           I    ++++G Y+C A + AG  + ++ ++    +   P  ++   +  V  G +  L C
Sbjct: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIV----VTDPPPQLVPAPNVTVSPGETAVLSC 421

Query: 352 MATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQ--NITQRDHGRFTCHANNSHGTVQA 409
              G     +TW RD  +    +  VA  + L L+   I   D GR+ C A+N++G  +A
Sbjct: 422 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 481

Query: 410 AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLS 469
           +  ++V+  PQ ++    Q   +   V+  C A G P P I W++    L  + +  V +
Sbjct: 482 SVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 541

Query: 470 SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQL--TVKPKALAVFTQLPQDTSVEVGKN 527
            GTL I   A  D G Y CQA + +G  + +V L  T  P   AV   +     V VG+ 
Sbjct: 542 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV----LVAVGEE 597

Query: 528 INISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
             + C A G P P + W + G+++  + +      G L I  A   D G Y C A N  G
Sbjct: 598 AVLVCEASGVPPPRVIWYRGGLEMILAPE--GSSSGKLRIPAAQERDAGTYTCRAVNELG 655

Query: 588 LAVTNMFLTV 597
            A   + L V
Sbjct: 656 DASAEIQLAV 665



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 28/110 (25%), Positives = 44/110 (40%), Gaps = 1/110 (0%)

Query: 240  PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299
            P  V   +G  V   C A+G+P P + W  ++  +      R  +   G+L +   +  D
Sbjct: 963  PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP-PITNRYGLLPSGSLRLAQVQVGD 1021

Query: 300  QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTL 349
             G Y+C A N AG A  +  +        +P  +  P     L G S  L
Sbjct: 1022 SGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPL 1071


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  174 bits (441), Expect = 6e-43
 Identities = 119/416 (28%), Positives = 186/416 (44%), Gaps = 44/416 (10%)

Query: 242  DVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQG 301
            D+    G+  +  C+A G+P+P I W  +   +   +  +  +   G L+++N    D G
Sbjct: 2855 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEG-KFTIQPSGELLVKNLEGQDAG 2913

Query: 302  VYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLI 361
             Y C A N+ G A+ +  +    ++   P F   P D  + +G    L C A G P P I
Sbjct: 2914 TYTCTAENAVGRARRRVHL----TILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRI 2969

Query: 362  TWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQF 421
             WT ++    +G       S L    +++ D G + C A N  G  QA + + V+  P  
Sbjct: 2970 GWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-- 3027

Query: 422  TVTPKDQVVLEEHAVEWL-----------CEADGNPPPVIVWTKTGGQLPVEGQHT--VL 468
                    VL+  A  +L           C   G+P P I W K G  LP+ G H    L
Sbjct: 3028 --------VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDG--LPLRGSHLRHQL 3077

Query: 469  SSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNI 528
             +G+L I R  + D G+Y+C A + +GV K  V L ++  +  VF   PQD +V  G ++
Sbjct: 3078 QNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQ--SAPVFQVEPQDMTVRSGDDV 3135

Query: 529  NISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGL 588
             + C A GEP P I W + G  +  S +     +G+L + +    D G Y+CVA N  G 
Sbjct: 3136 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGS 3195

Query: 589  AVTNMFLTVT------------AIQGRQAGDDFVESSILDAVQRVDSAINSTRRHL 632
            A    FL V              I GR+ G   + +S++       S+I+S+ RH+
Sbjct: 3196 ATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSVMQEAHSGVSSIHSSIRHV 3251



 Score =  165 bits (417), Expect = 3e-40
 Identities = 119/370 (32%), Positives = 159/370 (42%), Gaps = 14/370 (3%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P I   P  V V    T    C+A+G P P + W  +   LD     R  +  +G+L I+
Sbjct: 2482 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD-PRSPRFEILPEGSLRIQ 2540

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMA 353
                 D G Y C+A NSAG  + Q   LR    PA       P +  +   T   L C A
Sbjct: 2541 PVLAQDAGHYLCLASNSAGSDR-QGRDLRVLEPPA---IAPSPSNLTLTAHTPALLPCEA 2596

Query: 354  TGHPHPLITWTRDNGLELD-----GSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQ 408
            +G P PL+ W +D G +LD     G+  +  S+ L L     +D  +F C  +N  G   
Sbjct: 2597 SGSPKPLVVWWKD-GQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH 2655

Query: 409  AAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQ-HTV 467
                + V  PP       D  V     V   C + G P P + W+K G QL   G  + V
Sbjct: 2656 RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRV 2715

Query: 468  LSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKN 527
              SG L I +A     G+Y C A +S GV    V LTV  +A  V   LP        + 
Sbjct: 2716 SPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTV--QASPVVKPLPSVVRAVAEEE 2773

Query: 528  INISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
            + + C A G P+P ITW KEG+ +       V   G L I  A   D G Y C+A+NS G
Sbjct: 2774 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAG 2833

Query: 588  LAVTNMFLTV 597
             A+    L V
Sbjct: 2834 SAMGKTRLVV 2843



 Score =  155 bits (391), Expect = 4e-37
 Identities = 107/373 (28%), Positives = 159/373 (42%), Gaps = 10/373 (2%)

Query: 232  QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLNVFDDGTL 290
            + P I   P ++ + +       C A G+PKP ++W  +   LD         +     L
Sbjct: 2571 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNAL 2630

Query: 291  MIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLE 350
            ++      D   ++C+  N  GEA      L   ++   P+      D  V +     L 
Sbjct: 2631 LLTAPGPQDSAQFECVVSNEVGEAHR----LYQVTVHVPPTIADDQTDFTVTMMAPVVLT 2686

Query: 351  CMATGHPHPLITWTRDNG-LELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQ 408
            C +TG P P ++W++    L   GS + V+ S  L +        GR+TC A NS G   
Sbjct: 2687 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2746

Query: 409  AAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVL 468
                + VQA P     P     + E  V   CEA G P P I W K G  +       VL
Sbjct: 2747 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVL 2806

Query: 469  SSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNI 528
              G LRI  A+  D G Y C A +S G      +L V+   + +   LP D S   G + 
Sbjct: 2807 PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV-IENGLP-DLSTTEGSHA 2864

Query: 529  NISCHAQGEPQPIITWNKEGVQIT-ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
             + C A+G P+P ITW+K+G  ++   GKF +   G L + +    D G Y C A N+ G
Sbjct: 2865 FLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG 2924

Query: 588  LAVTNMFLTVTAI 600
             A   + LT+  +
Sbjct: 2925 RARRRVHLTILVL 2937



 Score =  151 bits (382), Expect = 4e-36
 Identities = 102/353 (28%), Positives = 160/353 (45%), Gaps = 17/353 (4%)

Query: 255  CRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT-LMIRNTRESDQGVYQCMARNSAGE 313
            C  E  P P+I W  +   + L++D      + G  L ++    +D G Y C ARN+AG 
Sbjct: 2412 CSVEAEPAPKITW--HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS 2469

Query: 314  AKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDG 373
                  +     +   P+    P    V +  +  L C A G P PL++W +D  + LD 
Sbjct: 2470 TSVAFRV----EIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR-VPLDP 2524

Query: 374  SR---HVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVV 430
                  +     L +Q +  +D G + C A+NS G+ +   ++ V  PP    +P +  +
Sbjct: 2525 RSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTL 2584

Query: 431  LEEHAVEWLCEADGNPPPVIVWTKTGGQLPV---EGQHTVLSSGTLRIDRAAQHDQGQYE 487
                     CEA G+P P++VW K G +L     +G + +L S  L +      D  Q+E
Sbjct: 2585 TAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFE 2644

Query: 488  CQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKE 547
            C   + +G      Q+TV         Q   D +V +   + ++CH+ G P P ++W+K 
Sbjct: 2645 CVVSNEVGEAHRLYQVTVHVPPTIADDQ--TDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2702

Query: 548  GVQITESGK-FHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTA 599
            G Q+   G  + V   G L I  A     GRY C ARNS G+A  ++FLTV A
Sbjct: 2703 GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQA 2755



 Score =  137 bits (346), Expect = 6e-32
 Identities = 110/355 (30%), Positives = 158/355 (44%), Gaps = 29/355 (8%)

Query: 245  VPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVF-DDGTLMIRNTRESDQGVY 303
            V  G  V   C A+G P P++ W+ +   L  +    L  + D G+L+++  R SD G Y
Sbjct: 2038 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 2097

Query: 304  QCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLI---GTSTTLECMATGHPHPL 360
             C+A N AGE     A L   ++   P+       +  L+   G   T+ C   G P   
Sbjct: 2098 TCVAHNPAGE----DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH 2153

Query: 361  ITWTRDNGLELDGS-RHVATSSG--LYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
            ++W +D GL L  S R +   SG  L +  +   D G FTC A +  G       + VQ 
Sbjct: 2154 VSWLKD-GLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV 2212

Query: 418  PPQFTVTP--KDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG-TLR 474
            PP         D VV+    VE  CEA G P P++ W K G  L  +     L  G +L+
Sbjct: 2213 PPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS----LEQGPSLQ 2268

Query: 475  IDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHA 534
            ++     D G Y C AVS  G  +   QLTV        +  P + S+  G  + + C A
Sbjct: 2269 LEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDA 2328

Query: 535  QGEPQPIITWNKEGVQITESGKFHVDDEGT--LTIYDAGFPDQGRYECVARNSFG 587
            QG PQP ITW+K+G  +T   +   +   T  L + DAG      Y C+A +  G
Sbjct: 2329 QGTPQPNITWHKDGQALT---RLENNSRATRVLRVRDAGL-----YTCLAESPAG 2375



 Score =  135 bits (340), Expect = 3e-31
 Identities = 112/369 (30%), Positives = 160/369 (43%), Gaps = 24/369 (6%)

Query: 244  EVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMIRNTRESDQGV 302
            E+   N  Y  C     P P++ W   +  L   D+  ++V   G  L I   R  + G 
Sbjct: 1570 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE--VSVLQGGRVLQIPLVRAENAGR 1627

Query: 303  YQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDT---EVLIGTSTT--LECMATGHP 357
            Y C A N  GE       L Y  L   P  ++   +    EV +  S+T  L+C A G+P
Sbjct: 1628 YSCKASNEVGED-----WLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNP 1682

Query: 358  HPLITWTRDNGLELDGS-RHVATSSGLYLQNITQR--DHGRFTCHANNSHGTVQAAANII 414
             P I+W + NGL    S R      G  LQ  T    D   + C A N  G+ +    + 
Sbjct: 1683 VPTISWLQ-NGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLR 1741

Query: 415  VQAPPQFTVTPKDQVV-LEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGT- 472
            VQ PP+      +QV  +   +V   C+   +P P + W K    L + G+   L  GT 
Sbjct: 1742 VQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSL-GEEVFLLPGTH 1800

Query: 473  -LRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKALAVFTQLPQD-TSVEVGKNIN 529
             L++ RA   D G Y C+A+++ G  +  VQL+V  P A     + PQD   V VG    
Sbjct: 1801 TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAV 1860

Query: 530  ISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFGL 588
            +SC     P+P +TW K+G  +  + +      G  L I +A   D+G Y C   N  G 
Sbjct: 1861 LSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1920

Query: 589  AVTNMFLTV 597
            AV    LTV
Sbjct: 1921 AVRTFTLTV 1929



 Score =  135 bits (339), Expect = 4e-31
 Identities = 108/378 (28%), Positives = 160/378 (42%), Gaps = 31/378 (8%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM-IRNTRE 297
            E   + V  G+    +C   G P P+I W  +   L  E     +V   G L+ +   + 
Sbjct: 977  ESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQL 1036

Query: 298  SDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHP 357
            + +G Y C   N  G + +Q   L     P        P    V+     TLEC ATG P
Sbjct: 1037 AQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP 1095

Query: 358  HPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDH---------GRFTCHANNSHGTVQ 408
             P +TW RD        + V    GL LQN  Q  H         GR++C A N  G  +
Sbjct: 1096 PPTVTWERD-------GQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAE 1148

Query: 409  AAANIIVQAPPQF--TVTPKDQVVLEEHA-VEWLCEADGNPPPVIVWTKTGGQLPVE-GQ 464
                + V  PP+    + P   +    H+ +  LCEA G PPP I W +  G+ PV  G+
Sbjct: 1149 RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGE 1206

Query: 465  HTVLSSG--TLRIDRAAQHDQGQYECQAVSSLGV--KKVSVQLTVKPKALAVFTQLPQDT 520
             T L +G   L++ +  + D G Y C A +  G   +  SV++ V P        L +  
Sbjct: 1207 DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS--IENEDLEEVI 1264

Query: 521  SVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGT-LTIYDAGFPDQGRYE 579
             V  G+  ++ C+  G PQP +TW K+G  +      H+  +G  L +  A     G Y 
Sbjct: 1265 KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYS 1324

Query: 580  CVARNSFGLAVTNMFLTV 597
            C+A N+ G    +  L+V
Sbjct: 1325 CIAANAVGEKTKHFQLSV 1342



 Score =  134 bits (338), Expect = 5e-31
 Identities = 108/353 (30%), Positives = 152/353 (43%), Gaps = 29/353 (8%)

Query: 255  CRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEA 314
            C A G P P I W      +   +DT L +     L +  T+E D G+Y C+A N AGEA
Sbjct: 1183 CEAMGIPPPAIRWFRGEEPVSPGEDTYL-LAGGWMLKMTQTQEQDSGLYSCLASNEAGEA 1241

Query: 315  KTQSAMLRYSSLPAKPSFVIQPQDTE----VLIGTSTTLECMATGHPHPLITWTRDNGLE 370
            +   ++     +   PS  I+ +D E    VL G +  L C  TGHP P +TW +D    
Sbjct: 1242 RRNFSV----EVLVPPS--IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1295

Query: 371  LDGSRHVATSSGLYLQNITQR--DHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQ 428
              G  H  +  G+ LQ +       G ++C A N+ G       + V   P      +D 
Sbjct: 1296 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDS 1355

Query: 429  -----VVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV-LSSGT--LRIDRAAQ 480
                  V   + +  +CEA   P P I W K G   P E    + L  GT  L+I  A +
Sbjct: 1356 ADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--PFEASRNIQLLPGTHGLQILNAQK 1413

Query: 481  HDQGQYECQAVSSLG--VKKVSVQLTVKP---KALAVFTQLPQDTSVEVGKNINISCHAQ 535
             D GQY C   + LG  VK   V++ + P   K   +     ++   +V   + + C + 
Sbjct: 1414 EDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW 1473

Query: 536  GEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFG 587
              P P I W K+G  +T S +  V  EG  L I      D GRY CVA N  G
Sbjct: 1474 AVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1526



 Score =  133 bits (335), Expect = 1e-30
 Identities = 100/362 (27%), Positives = 159/362 (43%), Gaps = 28/362 (7%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
            +P ++ +  G  +   C A+G P+P I W  +  +L     TRL   ++ +   R  R  
Sbjct: 2310 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-----TRL---ENNSRATRVLRVR 2361

Query: 299  DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTS---TTLECMATG 355
            D G+Y C+A + AG A  +S  +R  +    P  ++ P+    ++G +     LEC    
Sbjct: 2362 DAGLYTCLAESPAG-AIEKSFRVRVQA----PPNIVGPRGPRFVVGLAPGQLVLECSVEA 2416

Query: 356  HPHPLITWTRDNGLELDGSRHV---ATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAAN 412
             P P ITW RD G+ L    H         L LQ ++  D G ++C A N+ G+   A  
Sbjct: 2417 EPAPKITWHRD-GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475

Query: 413  IIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL-PVEGQHTVLSSG 471
            + +   P     P    V         C+ADG P P++ W K    L P   +  +L  G
Sbjct: 2476 VEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG 2535

Query: 472  TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKALAVFTQLPQDTSVEVGKNINI 530
            +LRI      D G Y C A +S G  +    L V +P A+A     P + ++       +
Sbjct: 2536 SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIA---PSPSNLTLTAHTPALL 2592

Query: 531  SCHAQGEPQPIITWNKEGVQI---TESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
             C A G P+P++ W K+G ++    + G + +     L +   G  D  ++ECV  N  G
Sbjct: 2593 PCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG 2652

Query: 588  LA 589
             A
Sbjct: 2653 EA 2654



 Score =  131 bits (329), Expect = 5e-30
 Identities = 103/377 (27%), Positives = 159/377 (42%), Gaps = 33/377 (8%)

Query: 247 SGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCM 306
           +G ++   C A G P PEI+W+ +   + +        +D G   +   R  D+G     
Sbjct: 110 AGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHF 169

Query: 307 ARNSAGEAKTQSAMLRYS-----------------------SLPAKPSFVIQPQDTEV-- 341
            R   G +  + A    S                       S PA PS +      EV  
Sbjct: 170 PRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLG 229

Query: 342 LIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR---DHGRFTC 398
           L G    L+C  +G P P + WT+D    L G  H+       +  IT     D GR+ C
Sbjct: 230 LAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQC 289

Query: 399 HANNSHGTVQAAANIIVQAPPQFTVTPK--DQVVLEEHAVEWLCEADGNPPPVIVWTKTG 456
            A +  G       + V APP    + +  +  V+E+H V+ LCEA G P P I W K G
Sbjct: 290 VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 349

Query: 457 GQLPVEGQHTVLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKALAVFT 514
             LP   +      G  L++ RA   D G Y C+A +++G  + + +L V  P  +    
Sbjct: 350 ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAG 409

Query: 515 QLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGT-LTIYDAGFP 573
             P       G+ + + C A+G P P ++W+ EG+ + ES +  ++ +G+ L +   G  
Sbjct: 410 GRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEA 469

Query: 574 DQGRYECVARNSFGLAV 590
             G Y CVA +  G AV
Sbjct: 470 SSGLYSCVASSPAGEAV 486



 Score =  130 bits (326), Expect = 1e-29
 Identities = 109/375 (29%), Positives = 159/375 (42%), Gaps = 19/375 (5%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P I   P +  V    +V   C A G P P++ W   +  +       ++V D   L I 
Sbjct: 695  PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV-DGRVLRIE 753

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE--VLIGTSTTLEC 351
              + SD G Y+C+A N AG     S  LRY      P  +  P      VL+ T   L C
Sbjct: 754  QAQLSDAGSYRCVASNVAG-----STELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTC 808

Query: 352  MATGHPHPLITWTRD-NGLELDGSRHVATSSG---LYLQNITQRDHGRFTCHANNSHGTV 407
             ATG P P + W +D N +   G+  +    G   L L +    D GR++C A ++ G  
Sbjct: 809  NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 868

Query: 408  QAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL-PVEGQHT 466
            +    + V  PP       +  V+   +V   C++   PPPV+ W K G  L P  G H 
Sbjct: 869  RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL 928

Query: 467  VLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDT-SVEVG 525
                  L++DRA   D G Y C+A++  G  +    L V      VF      T +V  G
Sbjct: 929  SADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNV--WVAPVFPLRESHTLTVREG 986

Query: 526  KNINISCHAQGEPQPIITWNKEGVQI--TESGKFHVDDEGTLT-IYDAGFPDQGRYECVA 582
               ++SC  +G P P I+W K+G  +    +G  HV   G L  +  A    +G Y C  
Sbjct: 987  HPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC 1046

Query: 583  RNSFGLAVTNMFLTV 597
             N  G +  ++ L V
Sbjct: 1047 SNVVGNSSQDLQLEV 1061



 Score =  129 bits (324), Expect = 2e-29
 Identities = 116/470 (24%), Positives = 192/470 (40%), Gaps = 52/470 (11%)

Query: 241  QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ 300
            ++V V   N +   C A   P P I W+ +    +   + +L     G L I N ++ D 
Sbjct: 1358 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDA 1416

Query: 301  GVYQCMARNSAGEAKTQ---SAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHP 357
            G Y C+  N  GEA        ++  S     P   +  ++ +  + ++ TLEC +   P
Sbjct: 1417 GQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVP 1476

Query: 358  HPLITWTRDNGLELDGSRHVATSSG--LYLQNITQRDHGRFTCHANNSHGTVQAAANIIV 415
             P I W +D       SR      G  L +Q     D GR+ C A N  G      N+++
Sbjct: 1477 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1536

Query: 416  QAPPQFT---------------------VTPKDQVVLEEHAVEWLCEADGNPPPVIVWTK 454
            Q PP F                      VT   ++V E +     C+ +  PPP + W +
Sbjct: 1537 QVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV-ENNPAYLYCDTNAIPPPDLTWYR 1595

Query: 455  TGGQLPVEGQHTVLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV--KPKALA 511
                L    + +VL  G  L+I      + G+Y C+A + +G   +  +L V   P  L 
Sbjct: 1596 EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILG 1655

Query: 512  VFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDA 570
               +L ++ +V     +++ C A G P P I+W + G+  + S +  V ++G  L +  A
Sbjct: 1656 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTA 1715

Query: 571  GFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRR 630
               D   Y CVA N  G A   +F     +  R AG D         +++V + +NS+  
Sbjct: 1716 EVADAASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLD---------LEQVTAILNSSVS 1765

Query: 631  HLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIF----EHTLQLIRERV 676
                   H + ++     + +D   + +    E+F     HTLQL R R+
Sbjct: 1766 LPCDVHAHPNPEVT----WYKDSQALSLGE--EVFLLPGTHTLQLGRARL 1809



 Score =  128 bits (322), Expect = 4e-29
 Identities = 108/398 (27%), Positives = 169/398 (42%), Gaps = 31/398 (7%)

Query: 234  PRIT-FEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMI 292
            PRI   + + V     ++V   C    +P PE+ W  ++ +L L ++  L +    TL +
Sbjct: 1746 PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFL-LPGTHTLQL 1804

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE----VLIGTSTT 348
               R SD G+Y C A N+AG    +   L   S+   P+F   P+  +    V +G    
Sbjct: 1805 GRARLSDSGMYTCEALNAAG----RDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAV 1860

Query: 349  LECMATGHPHPLITWTRDNGLELDGSRHVATSSG--LYLQNITQRDHGRFTCHANNSHGT 406
            L C     P P +TW +D    +   R  A   G  L +Q     D G ++C  +N  G 
Sbjct: 1861 LSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1920

Query: 407  VQAAANIIVQAPPQFTVTPKDQVV--LEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQ 464
                  + VQ PP F   PK + V  +    +   C+  G P P + W K   ++PVE  
Sbjct: 1921 AVRTFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK--DRMPVESS 1977

Query: 465  --HTVLS-SGTLRIDRAAQHDQGQYECQAVSSLGV--KKVSVQLTVKPKALAVFTQLPQD 519
              H V+S  G L++ R      G Y C A ++     K   V + V P+  +  + + ++
Sbjct: 1978 AVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS--SGVARE 2035

Query: 520  TSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVD---DEGTLTIYDAGFPDQG 576
              V  G+ + + C A G+P P + W K+G  + +    H+    D G+L +      D G
Sbjct: 2036 HHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAG 2095

Query: 577  RYECVARNSFG----LAVTNMFLTVTAIQGRQAGDDFV 610
             Y CVA N  G    L   N+ +  T  QG       V
Sbjct: 2096 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLV 2133



 Score =  125 bits (315), Expect = 2e-28
 Identities = 100/372 (26%), Positives = 153/372 (41%), Gaps = 17/372 (4%)

Query: 237  TFEPQDVEVPS---GNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            TFE    E  S   G+ +  TC   G P P + W+ +   ++        V   G L + 
Sbjct: 1934 TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVE-SSAVHGVVSRGGRLQLS 1992

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMA 353
              + +  G Y C+A N+  EA+    +    +   + S V +  +  VL G    L+C A
Sbjct: 1993 RLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAR--EHHVLEGQEVRLDCEA 2050

Query: 354  TGHPHPLITWTRDNG-LELDGSRHVA---TSSGLYLQNITQRDHGRFTCHANNSHGTVQA 409
             G P P + W +D   L  D   H+        L L+ +   D G +TC A+N  G    
Sbjct: 2051 DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDAR 2110

Query: 410  AANIIVQAPPQFTVTPKDQVVLEEHA---VEWLCEADGNPPPVIVWTKTGGQLPVEGQHT 466
               + V  PP           L       V  +C   G+PP  + W K G  LP+  +  
Sbjct: 2111 LHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTL 2170

Query: 467  VLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVG 525
            +  SG TLRI +    D G + C A S  GV   +  L V+   +    +   D  V  G
Sbjct: 2171 LHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRG 2230

Query: 526  KNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + + C A+G P P+++W K+G  +       ++   +L +   G  D G Y CVA + 
Sbjct: 2231 SLVELPCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSE 2287

Query: 586  FGLAVTNMFLTV 597
             G A  +  LTV
Sbjct: 2288 AGEARRHFQLTV 2299



 Score =  120 bits (301), Expect = 1e-26
 Identities = 108/369 (29%), Positives = 163/369 (44%), Gaps = 19/369 (5%)

Query: 241 QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMIRNTRESD 299
           Q+V   +G  V   C   G P P++ W  +   + L     L V +DG  L I  +   D
Sbjct: 225 QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGD 283

Query: 300 QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLE--CMATGHP 357
           +G YQC+A + AG+ + +   LR   + A P+     +  EV +     ++  C A G P
Sbjct: 284 EGRYQCVAFSPAGQ-QARDFQLR---VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 339

Query: 358 HPLITWTRDNGLELDGSRHVATSSGLYLQ--NITQRDHGRFTCHANNSHGTVQAAANIIV 415
            P ITW +D  L    ++ V T  G  LQ       D G +TC A+N+ G  + A  + V
Sbjct: 340 TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 399

Query: 416 QAPPQFTVTPKDQVVLEEHA---VEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGT 472
             PP          V++  A   V   C A G+P P + W   G  +    +  + + G+
Sbjct: 400 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS 459

Query: 473 -LRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNIN 529
            LR++   +   G Y C A S  G  V + SV++ V P+ L V   L Q T++ VG+ + 
Sbjct: 460 VLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLL-VAEGLGQVTTI-VGQPLE 517

Query: 530 ISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFGL 588
           + C A G P P I W + G    E     V  +G TL I        G + C A N  G 
Sbjct: 518 LPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGT 577

Query: 589 AVTNMFLTV 597
           A   + ++V
Sbjct: 578 AGAEVEVSV 586



 Score =  120 bits (300), Expect = 1e-26
 Identities = 87/315 (27%), Positives = 137/315 (43%), Gaps = 13/315 (4%)

Query: 290 LMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTL 349
           L I      D+G+Y C A N AGE+K + A+     +   P+    P +  VL   S TL
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVAL----KVLVPPNIEPGPVNKAVLENASVTL 714

Query: 350 ECMATGHPHPLITWTRDNGLELDGSRHVATSSG--LYLQNITQRDHGRFTCHANNSHGTV 407
           EC+A+G P P ++W + +           +  G  L ++     D G + C A+N  G+ 
Sbjct: 715 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 774

Query: 408 QAAANIIVQAPPQFTVTPK-DQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLP---VEG 463
           +    + V  PP+ T+ P     VL    V   C A G P P ++W K G  +      G
Sbjct: 775 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 834

Query: 464 QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVE 523
                    L +  A   D G+Y C AVS++G  +  V L V      +  +L  + SV 
Sbjct: 835 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEEL--NVSVV 892

Query: 524 VGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVD-DEGTLTIYDAGFPDQGRYECVA 582
             +++ + C +   P P+++W K+G  +      H+  D+  L +  A   D G Y C A
Sbjct: 893 ANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA 952

Query: 583 RNSFGLAVTNMFLTV 597
            N  G +  +  L V
Sbjct: 953 LNQAGRSEKHYNLNV 967



 Score =  119 bits (297), Expect = 3e-26
 Identities = 96/374 (25%), Positives = 158/374 (42%), Gaps = 22/374 (5%)

Query: 248  GNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMA 307
            G  V   C   G+P   + W+ +   L L   T L+     TL I   + +D G++ C+A
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHG-SGHTLRISKVQLADAGIFTCVA 2195

Query: 308  RNSAGEAKTQSAMLRYSSLPAKPSFVIQP----QDTEVLIGTSTTLECMATGHPHPLITW 363
             + AG A       R  +L  +   V++P     D  V+ G+   L C A G P PL++W
Sbjct: 2196 ASPAGVAD------RNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW 2249

Query: 364  TRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTV 423
             +D    L  S+ +     L L+ +   D G ++C A +  G  +    + V  PP    
Sbjct: 2250 MKDGEPLL--SQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIED 2307

Query: 424  T--PKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQH 481
            +  P +  +     +E LC+A G P P I W K G  L    ++   ++  LR+      
Sbjct: 2308 SGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-TRLENNSRATRVLRV-----R 2361

Query: 482  DQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPI 541
            D G Y C A S  G  + S ++ V+     V  + P+         + + C  + EP P 
Sbjct: 2362 DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPK 2421

Query: 542  ITWNKEGVQITESGKFHVDDEGT-LTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAI 600
            ITW+++G+ + E       + G  L +      D G Y C ARN+ G       + +  +
Sbjct: 2422 ITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV 2481

Query: 601  QGRQAGDDFVESSI 614
               ++G   V  S+
Sbjct: 2482 PTIRSGPPAVNVSV 2495



 Score =  116 bits (291), Expect = 1e-25
 Identities = 85/279 (30%), Positives = 123/279 (44%), Gaps = 17/279 (6%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMI 292
            P  T  P D  +  G+ ++  C A G+P P I W  N+  +       ++  D G TL  
Sbjct: 2938 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQR 2993

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLI---GTSTTL 349
                  D G Y C A N  G  +TQ+     S +  K + V+Q +    L+   G S  L
Sbjct: 2994 AAVSREDSGTYVCWAENRVG--RTQAV----SFVHVKEAPVLQGEAFSYLVEPVGGSIQL 3047

Query: 350  ECMATGHPHPLITWTRDNGLELDGS--RHVATSSGLYLQNITQRDHGRFTCHANNSHGTV 407
            +C+  G P P I W +D GL L GS  RH   +  L +    + D GR+ C A N  G  
Sbjct: 3048 DCVVRGDPVPDIHWIKD-GLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVA 3106

Query: 408  QAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV 467
            +    +++Q+ P F V P+D  V     V   C+A G P P I W + G  L    +   
Sbjct: 3107 KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 3166

Query: 468  LSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVK 506
            L  G+L ++     D G Y+C A + LG       L V+
Sbjct: 3167 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205



 Score =  107 bits (268), Expect = 6e-23
 Identities = 98/372 (26%), Positives = 141/372 (37%), Gaps = 41/372 (11%)

Query: 255 CRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEA 314
           C   G PKP++ W     S  L     + V ++G+L + +   +D G Y+C A N  G  
Sbjct: 24  CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83

Query: 315 KTQSAMLRYSSLPAKPSFVIQPQDTEV--LIGTSTTLECMATGHPHPLITWTRDNGL--- 369
             ++ ++ Y      PS     +   V  + G S TLEC A G P P I W +D  L   
Sbjct: 84  SRRAKLVVY----VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGV 139

Query: 370 --------------ELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTV---QAAAN 412
                         ++ G R +     L+   I     GR    A  S  T     A   
Sbjct: 140 PLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLA 199

Query: 413 IIVQAPPQFTVTP------------KDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLP 460
              Q P     +P            ++ + L    VE  C   G P P + WTK    + 
Sbjct: 200 GFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVL 259

Query: 461 VEGQHTVLSSG--TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQ 518
             G H  +      LRI  +   D+G+Y+C A S  G +    QL V        +    
Sbjct: 260 PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETG 319

Query: 519 DTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGR 577
           + +V     + + C A+G P P ITW K+G  +  S K      G  L +  A   D G 
Sbjct: 320 EVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV 379

Query: 578 YECVARNSFGLA 589
           Y C A N+ G A
Sbjct: 380 YTCKASNAVGAA 391



 Score =  105 bits (263), Expect = 2e-22
 Identities = 99/374 (26%), Positives = 156/374 (41%), Gaps = 39/374 (10%)

Query: 240 PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299
           P  V+  +G  V   C A G+P P + W H    +   +++RL   D   L + +  E+ 
Sbjct: 412 PYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET-DGSVLRLESPGEAS 470

Query: 300 QGVYQCMARNSAGEAKTQSAMLRYS-SLPAKPSFVIQPQDTEV--LIGTSTTLECMATGH 356
            G+Y C+A + AGE     A+L+YS  +   P  ++     +V  ++G    L C A+G 
Sbjct: 471 SGLYSCVASSPAGE-----AVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGS 525

Query: 357 PHPLITWTRDN--GLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANII 414
           P P I W ++     EL G +  +  + L++ ++     G F C A N  GT  A   + 
Sbjct: 526 PVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVS 585

Query: 415 VQ---APPQFTVTPKDQVVLEEHAVEW--LCE--------ADGNPPPVIVWTKTGGQLPV 461
           V    AP    V         EH   +   C+        A   PP V  W   G    +
Sbjct: 586 VHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS---L 642

Query: 462 EGQHTVLSSG-----TLRIDRAAQHDQGQYECQAVSSLGVKK--VSVQLTVKPKALAVFT 514
            G+ T +         L+I++    D+G Y C A +  G  K  V++++ V P       
Sbjct: 643 WGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN----IE 698

Query: 515 QLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFP 573
             P + +V    ++ + C A G P P ++W K    ++      V  +G  L I  A   
Sbjct: 699 PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLS 758

Query: 574 DQGRYECVARNSFG 587
           D G Y CVA N  G
Sbjct: 759 DAGSYRCVASNVAG 772



 Score =  101 bits (252), Expect = 5e-21
 Identities = 79/275 (28%), Positives = 116/275 (42%), Gaps = 13/275 (4%)

Query: 239 EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG--TLMIRNTR 296
           E  +V V   + V   C A G P P I W  +   L         V+  G   L +   +
Sbjct: 317 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKV---VYTRGGRQLQLGRAQ 373

Query: 297 ESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGH 356
            SD GVY C A N+ G A+  + +  Y   P       +P   + + G    LEC+A GH
Sbjct: 374 SSDAGVYTCKASNAVGAAEKATRLDVYVP-PTIEGAGGRPYVVKAVAGRPVALECVARGH 432

Query: 357 PHPLITWTRDNGL---ELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANI 413
           P P ++W  + GL   E + SR     S L L++  +   G ++C A++  G      ++
Sbjct: 433 PSPTLSWHHE-GLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSV 491

Query: 414 IVQAPPQFTVTP--KDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG 471
            VQ PPQ  V         +    +E  C+A G+P P I W + G          V S G
Sbjct: 492 EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG 551

Query: 472 -TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
            TL ID       G + CQA +  G     V+++V
Sbjct: 552 TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 586



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 74/291 (25%), Positives = 108/291 (37%), Gaps = 48/291 (16%)

Query: 351 CMATGHPHPLITWTRDNGLE-LDGSRHVAT--SSGLYLQNITQRDHGRFTCHANNSHGTV 407
           C   G P P +TW +    E L G   VA      L+L +++  D G + C A N  G+ 
Sbjct: 24  CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83

Query: 408 QAAANIIVQAPPQFTVTPKDQVV--LEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE--- 462
              A ++V  PP      +   V  +   ++   C+A+G P P IVW K    + V    
Sbjct: 84  SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGW 143

Query: 463 ------------GQHTVLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKA 509
                       G H +L  G +L   R      G+   QA  S   K            
Sbjct: 144 AGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTK------APWXAG 197

Query: 510 LAVFTQLP-------------------QDTSVEVGKNINISCHAQGEPQPIITWNKEGVQ 550
           LA F Q P                   Q+     G ++ + C   G P P + W K+   
Sbjct: 198 LAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQP 257

Query: 551 ITESGK-FHVDDEG-TLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTA 599
           +   G    V ++G  L I  +   D+GRY+CVA +  G    +  L V A
Sbjct: 258 VLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHA 308



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 31/89 (34%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 233  SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMI 292
            +P    EPQD+ V SG+ V   C+A G P P I W+       L    RL    DG+L +
Sbjct: 3117 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQ--PLRASRRLRTLPDGSLWL 3174

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAML 321
             N    D G Y C+A N  G A  ++ ++
Sbjct: 3175 ENVETGDAGTYDCVAHNLLGSATARAFLV 3203


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  174 bits (440), Expect = 7e-43
 Identities = 119/416 (28%), Positives = 186/416 (44%), Gaps = 44/416 (10%)

Query: 242  DVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQG 301
            D+    G+  +  C+A G+P+P I W  +   +   +  +  +   G L+++N    D G
Sbjct: 2764 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEG-KFTIQPSGELLVKNLEGQDAG 2822

Query: 302  VYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLI 361
             Y C A N+ G A+ +  +    ++   P F   P D  + +G    L C A G P P I
Sbjct: 2823 TYTCTAENAVGRARRRVHL----TILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRI 2878

Query: 362  TWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQF 421
             WT ++    +G       S L    +++ D G + C A N  G  QA + + V+  P  
Sbjct: 2879 GWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-- 2936

Query: 422  TVTPKDQVVLEEHAVEWL-----------CEADGNPPPVIVWTKTGGQLPVEGQHT--VL 468
                    VL+  A  +L           C   G+P P I W K G  LP+ G H    L
Sbjct: 2937 --------VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDG--LPLRGSHLRHQL 2986

Query: 469  SSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNI 528
             +G+L I R  + D G+Y+C A + +GV K  V L ++  +  VF   PQD +V  G ++
Sbjct: 2987 QNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQ--SAPVFQVEPQDMTVRSGDDV 3044

Query: 529  NISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGL 588
             + C A GEP P I W + G  +  S +     +G+L + +    D G Y+CVA N  G 
Sbjct: 3045 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGS 3104

Query: 589  AVTNMFLTVT------------AIQGRQAGDDFVESSILDAVQRVDSAINSTRRHL 632
            A    FL V              I GR+ G   + +S++       S+I+S+ RH+
Sbjct: 3105 ATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSVMQEAHSGVSSIHSSIRHV 3160



 Score =  165 bits (417), Expect = 3e-40
 Identities = 119/370 (32%), Positives = 159/370 (42%), Gaps = 14/370 (3%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P I   P  V V    T    C+A+G P P + W  +   LD     R  +  +G+L I+
Sbjct: 2391 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD-PRSPRFEILPEGSLRIQ 2449

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMA 353
                 D G Y C+A NSAG  + Q   LR    PA       P +  +   T   L C A
Sbjct: 2450 PVLAQDAGHYLCLASNSAGSDR-QGRDLRVLEPPA---IAPSPSNLTLTAHTPALLPCEA 2505

Query: 354  TGHPHPLITWTRDNGLELD-----GSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQ 408
            +G P PL+ W +D G +LD     G+  +  S+ L L     +D  +F C  +N  G   
Sbjct: 2506 SGSPKPLVVWWKD-GQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH 2564

Query: 409  AAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQ-HTV 467
                + V  PP       D  V     V   C + G P P + W+K G QL   G  + V
Sbjct: 2565 RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRV 2624

Query: 468  LSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKN 527
              SG L I +A     G+Y C A +S GV    V LTV  +A  V   LP        + 
Sbjct: 2625 SPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTV--QASPVVKPLPSVVRAVAEEE 2682

Query: 528  INISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
            + + C A G P+P ITW KEG+ +       V   G L I  A   D G Y C+A+NS G
Sbjct: 2683 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAG 2742

Query: 588  LAVTNMFLTV 597
             A+    L V
Sbjct: 2743 SAMGKTRLVV 2752



 Score =  155 bits (391), Expect = 4e-37
 Identities = 107/373 (28%), Positives = 159/373 (42%), Gaps = 10/373 (2%)

Query: 232  QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLNVFDDGTL 290
            + P I   P ++ + +       C A G+PKP ++W  +   LD         +     L
Sbjct: 2480 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNAL 2539

Query: 291  MIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLE 350
            ++      D   ++C+  N  GEA      L   ++   P+      D  V +     L 
Sbjct: 2540 LLTAPGPQDSAQFECVVSNEVGEAHR----LYQVTVHVPPTIADDQTDFTVTMMAPVVLT 2595

Query: 351  CMATGHPHPLITWTRDNG-LELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQ 408
            C +TG P P ++W++    L   GS + V+ S  L +        GR+TC A NS G   
Sbjct: 2596 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2655

Query: 409  AAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVL 468
                + VQA P     P     + E  V   CEA G P P I W K G  +       VL
Sbjct: 2656 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVL 2715

Query: 469  SSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNI 528
              G LRI  A+  D G Y C A +S G      +L V+   + +   LP D S   G + 
Sbjct: 2716 PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV-IENGLP-DLSTTEGSHA 2773

Query: 529  NISCHAQGEPQPIITWNKEGVQIT-ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
             + C A+G P+P ITW+K+G  ++   GKF +   G L + +    D G Y C A N+ G
Sbjct: 2774 FLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG 2833

Query: 588  LAVTNMFLTVTAI 600
             A   + LT+  +
Sbjct: 2834 RARRRVHLTILVL 2846



 Score =  151 bits (382), Expect = 4e-36
 Identities = 102/353 (28%), Positives = 160/353 (45%), Gaps = 17/353 (4%)

Query: 255  CRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT-LMIRNTRESDQGVYQCMARNSAGE 313
            C  E  P P+I W  +   + L++D      + G  L ++    +D G Y C ARN+AG 
Sbjct: 2321 CSVEAEPAPKITW--HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS 2378

Query: 314  AKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDG 373
                  +     +   P+    P    V +  +  L C A G P PL++W +D  + LD 
Sbjct: 2379 TSVAFRV----EIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR-VPLDP 2433

Query: 374  SR---HVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVV 430
                  +     L +Q +  +D G + C A+NS G+ +   ++ V  PP    +P +  +
Sbjct: 2434 RSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTL 2493

Query: 431  LEEHAVEWLCEADGNPPPVIVWTKTGGQLPV---EGQHTVLSSGTLRIDRAAQHDQGQYE 487
                     CEA G+P P++VW K G +L     +G + +L S  L +      D  Q+E
Sbjct: 2494 TAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFE 2553

Query: 488  CQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKE 547
            C   + +G      Q+TV         Q   D +V +   + ++CH+ G P P ++W+K 
Sbjct: 2554 CVVSNEVGEAHRLYQVTVHVPPTIADDQ--TDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2611

Query: 548  GVQITESGK-FHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTA 599
            G Q+   G  + V   G L I  A     GRY C ARNS G+A  ++FLTV A
Sbjct: 2612 GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQA 2664



 Score =  145 bits (366), Expect = 3e-34
 Identities = 104/366 (28%), Positives = 161/366 (43%), Gaps = 24/366 (6%)

Query: 247 SGNTVYFTCRAEGNPKPEIIWIHNNH-------------SLDLEDDTRLNVFDDG-TLMI 292
           +G ++   C A G P PEI+W+ +                L         + D+G +L  
Sbjct: 32  AGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHF 91

Query: 293 RNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECM 352
              +E D G+Y C A N AG A+    +L  +  P         Q+   L G    L+C 
Sbjct: 92  PRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT--PPSVLGAGAAQEVLGLAGADVELQCW 149

Query: 353 ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR---DHGRFTCHANNSHGTVQA 409
            +G P P + WT+D    L G  H+       +  IT     D GR+ C A +  G    
Sbjct: 150 TSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQAR 209

Query: 410 AANIIVQAPPQFTVTPK--DQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV 467
              + V APP    + +  +  V+E+H V+ LCEA G P P I W K G  LP   +   
Sbjct: 210 DFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY 269

Query: 468 LSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKALAVFTQLPQDTSVEVG 525
              G  L++ RA   D G Y C+A +++G  + + +L V  P  +      P       G
Sbjct: 270 TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG 329

Query: 526 KNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGT-LTIYDAGFPDQGRYECVARN 584
           + + + C A+G P P ++W+ EG+ + ES +  ++ +G+ L +   G    G Y CVA +
Sbjct: 330 RPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASS 389

Query: 585 SFGLAV 590
             G AV
Sbjct: 390 PAGEAV 395



 Score =  137 bits (346), Expect = 6e-32
 Identities = 110/355 (30%), Positives = 158/355 (44%), Gaps = 29/355 (8%)

Query: 245  VPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVF-DDGTLMIRNTRESDQGVY 303
            V  G  V   C A+G P P++ W+ +   L  +    L  + D G+L+++  R SD G Y
Sbjct: 1947 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 2006

Query: 304  QCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLI---GTSTTLECMATGHPHPL 360
             C+A N AGE     A L   ++   P+       +  L+   G   T+ C   G P   
Sbjct: 2007 TCVAHNPAGE----DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH 2062

Query: 361  ITWTRDNGLELDGS-RHVATSSG--LYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
            ++W +D GL L  S R +   SG  L +  +   D G FTC A +  G       + VQ 
Sbjct: 2063 VSWLKD-GLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV 2121

Query: 418  PPQFTVTP--KDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG-TLR 474
            PP         D VV+    VE  CEA G P P++ W K G  L  +     L  G +L+
Sbjct: 2122 PPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS----LEQGPSLQ 2177

Query: 475  IDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHA 534
            ++     D G Y C AVS  G  +   QLTV        +  P + S+  G  + + C A
Sbjct: 2178 LEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDA 2237

Query: 535  QGEPQPIITWNKEGVQITESGKFHVDDEGT--LTIYDAGFPDQGRYECVARNSFG 587
            QG PQP ITW+K+G  +T   +   +   T  L + DAG      Y C+A +  G
Sbjct: 2238 QGTPQPNITWHKDGQALT---RLENNSRATRVLRVRDAGL-----YTCLAESPAG 2284



 Score =  135 bits (340), Expect = 3e-31
 Identities = 112/369 (30%), Positives = 160/369 (43%), Gaps = 24/369 (6%)

Query: 244  EVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMIRNTRESDQGV 302
            E+   N  Y  C     P P++ W   +  L   D+  ++V   G  L I   R  + G 
Sbjct: 1479 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE--VSVLQGGRVLQIPLVRAENAGR 1536

Query: 303  YQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDT---EVLIGTSTT--LECMATGHP 357
            Y C A N  GE       L Y  L   P  ++   +    EV +  S+T  L+C A G+P
Sbjct: 1537 YSCKASNEVGED-----WLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNP 1591

Query: 358  HPLITWTRDNGLELDGS-RHVATSSGLYLQNITQR--DHGRFTCHANNSHGTVQAAANII 414
             P I+W + NGL    S R      G  LQ  T    D   + C A N  G+ +    + 
Sbjct: 1592 VPTISWLQ-NGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLR 1650

Query: 415  VQAPPQFTVTPKDQVV-LEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGT- 472
            VQ PP+      +QV  +   +V   C+   +P P + W K    L + G+   L  GT 
Sbjct: 1651 VQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSL-GEEVFLLPGTH 1709

Query: 473  -LRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKALAVFTQLPQD-TSVEVGKNIN 529
             L++ RA   D G Y C+A+++ G  +  VQL+V  P A     + PQD   V VG    
Sbjct: 1710 TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAV 1769

Query: 530  ISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFGL 588
            +SC     P+P +TW K+G  +  + +      G  L I +A   D+G Y C   N  G 
Sbjct: 1770 LSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1829

Query: 589  AVTNMFLTV 597
            AV    LTV
Sbjct: 1830 AVRTFTLTV 1838



 Score =  135 bits (339), Expect = 4e-31
 Identities = 108/378 (28%), Positives = 160/378 (42%), Gaps = 31/378 (8%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM-IRNTRE 297
            E   + V  G+    +C   G P P+I W  +   L  E     +V   G L+ +   + 
Sbjct: 886  ESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQL 945

Query: 298  SDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHP 357
            + +G Y C   N  G + +Q   L     P        P    V+     TLEC ATG P
Sbjct: 946  AQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP 1004

Query: 358  HPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDH---------GRFTCHANNSHGTVQ 408
             P +TW RD        + V    GL LQN  Q  H         GR++C A N  G  +
Sbjct: 1005 PPTVTWERD-------GQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAE 1057

Query: 409  AAANIIVQAPPQF--TVTPKDQVVLEEHA-VEWLCEADGNPPPVIVWTKTGGQLPVE-GQ 464
                + V  PP+    + P   +    H+ +  LCEA G PPP I W +  G+ PV  G+
Sbjct: 1058 RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGE 1115

Query: 465  HTVLSSG--TLRIDRAAQHDQGQYECQAVSSLGV--KKVSVQLTVKPKALAVFTQLPQDT 520
             T L +G   L++ +  + D G Y C A +  G   +  SV++ V P        L +  
Sbjct: 1116 DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS--IENEDLEEVI 1173

Query: 521  SVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGT-LTIYDAGFPDQGRYE 579
             V  G+  ++ C+  G PQP +TW K+G  +      H+  +G  L +  A     G Y 
Sbjct: 1174 KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYS 1233

Query: 580  CVARNSFGLAVTNMFLTV 597
            C+A N+ G    +  L+V
Sbjct: 1234 CIAANAVGEKTKHFQLSV 1251



 Score =  135 bits (339), Expect = 4e-31
 Identities = 108/353 (30%), Positives = 152/353 (43%), Gaps = 29/353 (8%)

Query: 255  CRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEA 314
            C A G P P I W      +   +DT L +     L +  T+E D G+Y C+A N AGEA
Sbjct: 1092 CEAMGIPPPAIRWFRGEEPVSPGEDTYL-LAGGWMLKMTQTQEQDSGLYSCLASNEAGEA 1150

Query: 315  KTQSAMLRYSSLPAKPSFVIQPQDTE----VLIGTSTTLECMATGHPHPLITWTRDNGLE 370
            +   ++     +   PS  I+ +D E    VL G +  L C  TGHP P +TW +D    
Sbjct: 1151 RRNFSV----EVLVPPS--IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1204

Query: 371  LDGSRHVATSSGLYLQNITQR--DHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQ 428
              G  H  +  G+ LQ +       G ++C A N+ G       + V   P      +D 
Sbjct: 1205 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDS 1264

Query: 429  -----VVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV-LSSGT--LRIDRAAQ 480
                  V   + +  +CEA   P P I W K G   P E    + L  GT  L+I  A +
Sbjct: 1265 ADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--PFEASRNIQLLPGTHGLQILNAQK 1322

Query: 481  HDQGQYECQAVSSLG--VKKVSVQLTVKP---KALAVFTQLPQDTSVEVGKNINISCHAQ 535
             D GQY C   + LG  VK   V++ + P   K   +     ++   +V   + + C + 
Sbjct: 1323 EDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESW 1382

Query: 536  GEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFG 587
              P P I W K+G  +T S +  V  EG  L I      D GRY CVA N  G
Sbjct: 1383 AVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1435



 Score =  133 bits (335), Expect = 1e-30
 Identities = 100/362 (27%), Positives = 159/362 (43%), Gaps = 28/362 (7%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
            +P ++ +  G  +   C A+G P+P I W  +  +L     TRL   ++ +   R  R  
Sbjct: 2219 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-----TRL---ENNSRATRVLRVR 2270

Query: 299  DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTS---TTLECMATG 355
            D G+Y C+A + AG A  +S  +R  +    P  ++ P+    ++G +     LEC    
Sbjct: 2271 DAGLYTCLAESPAG-AIEKSFRVRVQA----PPNIVGPRGPRFVVGLAPGQLVLECSVEA 2325

Query: 356  HPHPLITWTRDNGLELDGSRHV---ATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAAN 412
             P P ITW RD G+ L    H         L LQ ++  D G ++C A N+ G+   A  
Sbjct: 2326 EPAPKITWHRD-GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384

Query: 413  IIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL-PVEGQHTVLSSG 471
            + +   P     P    V         C+ADG P P++ W K    L P   +  +L  G
Sbjct: 2385 VEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG 2444

Query: 472  TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKALAVFTQLPQDTSVEVGKNINI 530
            +LRI      D G Y C A +S G  +    L V +P A+A     P + ++       +
Sbjct: 2445 SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIA---PSPSNLTLTAHTPALL 2501

Query: 531  SCHAQGEPQPIITWNKEGVQI---TESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
             C A G P+P++ W K+G ++    + G + +     L +   G  D  ++ECV  N  G
Sbjct: 2502 PCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG 2561

Query: 588  LA 589
             A
Sbjct: 2562 EA 2563



 Score =  129 bits (325), Expect = 2e-29
 Identities = 109/375 (29%), Positives = 158/375 (42%), Gaps = 19/375 (5%)

Query: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
           P I   P +  V    +V   C A G P P++ W   +  +       ++V D   L I 
Sbjct: 604 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV-DGRVLRIE 662

Query: 294 NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE--VLIGTSTTLEC 351
             + SD G Y+C+A N AG     S  LRY      P  +  P      VL+ T   L C
Sbjct: 663 QAQLSDAGSYRCVASNVAG-----STELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTC 717

Query: 352 MATGHPHPLITWTRD-NGLELDGSRHVATSSG---LYLQNITQRDHGRFTCHANNSHGTV 407
            ATG P P + W +D N +   G+  +    G   L L +    D GR++C A ++ G  
Sbjct: 718 NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 777

Query: 408 QAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL-PVEGQHT 466
           +    + V  PP       +  V+   +V   C++   PPPV+ W K G  L P  G H 
Sbjct: 778 RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL 837

Query: 467 VLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDT-SVEVG 525
                 L++DRA   D G Y C+A++  G  +    L V      VF      T +V  G
Sbjct: 838 SADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV--WVAPVFPLRESHTLTVREG 895

Query: 526 KNINISCHAQGEPQPIITWNKEGVQI--TESGKFHVDDEGTLT-IYDAGFPDQGRYECVA 582
               +SC  +G P P I+W K+G  +    +G  HV   G L  +  A    +G Y C  
Sbjct: 896 HPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC 955

Query: 583 RNSFGLAVTNMFLTV 597
            N  G +  ++ L V
Sbjct: 956 SNVVGNSSQDLQLEV 970



 Score =  129 bits (325), Expect = 2e-29
 Identities = 116/470 (24%), Positives = 192/470 (40%), Gaps = 52/470 (11%)

Query: 241  QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ 300
            ++V V   N +   C A   P P I W+ +    +   + +L     G L I N ++ D 
Sbjct: 1267 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDA 1325

Query: 301  GVYQCMARNSAGEAKTQ---SAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHP 357
            G Y C+  N  GEA        ++  S     P   +  ++ +  + ++ TLEC +   P
Sbjct: 1326 GQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVP 1385

Query: 358  HPLITWTRDNGLELDGSRHVATSSG--LYLQNITQRDHGRFTCHANNSHGTVQAAANIIV 415
             P I W +D       SR      G  L +Q     D GR+ C A N  G      N+++
Sbjct: 1386 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1445

Query: 416  QAPPQFT---------------------VTPKDQVVLEEHAVEWLCEADGNPPPVIVWTK 454
            Q PP F                      VT   ++V E +     C+ +  PPP + W +
Sbjct: 1446 QVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV-ENNPAYLYCDTNAIPPPDLTWYR 1504

Query: 455  TGGQLPVEGQHTVLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV--KPKALA 511
                L    + +VL  G  L+I      + G+Y C+A + +G   +  +L V   P  L 
Sbjct: 1505 EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILG 1564

Query: 512  VFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDA 570
               +L ++ +V     +++ C A G P P I+W + G+  + S +  V ++G  L +  A
Sbjct: 1565 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTA 1624

Query: 571  GFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRR 630
               D   Y CVA N  G A   +F     +  R AG D         +++V + +NS+  
Sbjct: 1625 EVADAASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLD---------LEQVTAILNSSVS 1674

Query: 631  HLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIF----EHTLQLIRERV 676
                   H + ++     + +D   + +    E+F     HTLQL R R+
Sbjct: 1675 LPCDVHAHPNPEVT----WYKDSQALSLGE--EVFLLPGTHTLQLGRARL 1718



 Score =  128 bits (322), Expect = 4e-29
 Identities = 108/398 (27%), Positives = 169/398 (42%), Gaps = 31/398 (7%)

Query: 234  PRIT-FEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMI 292
            PRI   + + V     ++V   C    +P PE+ W  ++ +L L ++  L +    TL +
Sbjct: 1655 PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFL-LPGTHTLQL 1713

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE----VLIGTSTT 348
               R SD G+Y C A N+AG    +   L   S+   P+F   P+  +    V +G    
Sbjct: 1714 GRARLSDSGMYTCEALNAAG----RDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAV 1769

Query: 349  LECMATGHPHPLITWTRDNGLELDGSRHVATSSG--LYLQNITQRDHGRFTCHANNSHGT 406
            L C     P P +TW +D    +   R  A   G  L +Q     D G ++C  +N  G 
Sbjct: 1770 LSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1829

Query: 407  VQAAANIIVQAPPQFTVTPKDQVV--LEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQ 464
                  + VQ PP F   PK + V  +    +   C+  G P P + W K   ++PVE  
Sbjct: 1830 AVRTFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK--DRMPVESS 1886

Query: 465  --HTVLS-SGTLRIDRAAQHDQGQYECQAVSSLGV--KKVSVQLTVKPKALAVFTQLPQD 519
              H V+S  G L++ R      G Y C A ++     K   V + V P+  +  + + ++
Sbjct: 1887 AVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS--SGVARE 1944

Query: 520  TSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVD---DEGTLTIYDAGFPDQG 576
              V  G+ + + C A G+P P + W K+G  + +    H+    D G+L +      D G
Sbjct: 1945 HHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAG 2004

Query: 577  RYECVARNSFG----LAVTNMFLTVTAIQGRQAGDDFV 610
             Y CVA N  G    L   N+ +  T  QG       V
Sbjct: 2005 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLV 2042



 Score =  125 bits (315), Expect = 2e-28
 Identities = 100/372 (26%), Positives = 153/372 (41%), Gaps = 17/372 (4%)

Query: 237  TFEPQDVEVPS---GNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            TFE    E  S   G+ +  TC   G P P + W+ +   ++        V   G L + 
Sbjct: 1843 TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVE-SSAVHGVVSRGGRLQLS 1901

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMA 353
              + +  G Y C+A N+  EA+    +    +   + S V +  +  VL G    L+C A
Sbjct: 1902 RLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAR--EHHVLEGQEVRLDCEA 1959

Query: 354  TGHPHPLITWTRDNG-LELDGSRHVA---TSSGLYLQNITQRDHGRFTCHANNSHGTVQA 409
             G P P + W +D   L  D   H+        L L+ +   D G +TC A+N  G    
Sbjct: 1960 DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDAR 2019

Query: 410  AANIIVQAPPQFTVTPKDQVVLEEHA---VEWLCEADGNPPPVIVWTKTGGQLPVEGQHT 466
               + V  PP           L       V  +C   G+PP  + W K G  LP+  +  
Sbjct: 2020 LHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTL 2079

Query: 467  VLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVG 525
            +  SG TLRI +    D G + C A S  GV   +  L V+   +    +   D  V  G
Sbjct: 2080 LHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRG 2139

Query: 526  KNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
              + + C A+G P P+++W K+G  +       ++   +L +   G  D G Y CVA + 
Sbjct: 2140 SLVELPCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSE 2196

Query: 586  FGLAVTNMFLTV 597
             G A  +  LTV
Sbjct: 2197 AGEARRHFQLTV 2208



 Score =  120 bits (301), Expect = 1e-26
 Identities = 108/369 (29%), Positives = 163/369 (44%), Gaps = 19/369 (5%)

Query: 241 QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMIRNTRESD 299
           Q+V   +G  V   C   G P P++ W  +   + L     L V +DG  L I  +   D
Sbjct: 134 QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGD 192

Query: 300 QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLE--CMATGHP 357
           +G YQC+A + AG+ + +   LR   + A P+     +  EV +     ++  C A G P
Sbjct: 193 EGRYQCVAFSPAGQ-QARDFQLR---VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 248

Query: 358 HPLITWTRDNGLELDGSRHVATSSGLYLQ--NITQRDHGRFTCHANNSHGTVQAAANIIV 415
            P ITW +D  L    ++ V T  G  LQ       D G +TC A+N+ G  + A  + V
Sbjct: 249 TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 308

Query: 416 QAPPQFTVTPKDQVVLEEHA---VEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGT 472
             PP          V++  A   V   C A G+P P + W   G  +    +  + + G+
Sbjct: 309 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS 368

Query: 473 -LRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNIN 529
            LR++   +   G Y C A S  G  V + SV++ V P+ L V   L Q T++ VG+ + 
Sbjct: 369 VLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLL-VAEGLGQVTTI-VGQPLE 426

Query: 530 ISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFGL 588
           + C A G P P I W + G    E     V  +G TL I        G + C A N  G 
Sbjct: 427 LPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGT 486

Query: 589 AVTNMFLTV 597
           A   + ++V
Sbjct: 487 AGAEVEVSV 495



 Score =  119 bits (299), Expect = 2e-26
 Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 13/305 (4%)

Query: 290 LMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTL 349
           L I      D+G+Y C A N AGE+K + A+     +   P+    P +  VL   S TL
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVAL----KVLVPPNIEPGPVNKAVLENASVTL 623

Query: 350 ECMATGHPHPLITWTRDNGLELDGSRHVATSSG--LYLQNITQRDHGRFTCHANNSHGTV 407
           EC+A+G P P ++W + +           +  G  L ++     D G + C A+N  G+ 
Sbjct: 624 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 683

Query: 408 QAAANIIVQAPPQFTVTPK-DQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLP---VEG 463
           +    + V  PP+ T+ P     VL    V   C A G P P ++W K G  +      G
Sbjct: 684 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 743

Query: 464 QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVE 523
                    L +  A   D G+Y C AVS++G  +  V L V      +  +L  + SV 
Sbjct: 744 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEEL--NVSVV 801

Query: 524 VGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVD-DEGTLTIYDAGFPDQGRYECVA 582
             +++ + C +   P P+++W K+G  +      H+  D+  L +  A   D G Y C A
Sbjct: 802 ANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA 861

Query: 583 RNSFG 587
            N  G
Sbjct: 862 LNQAG 866



 Score =  119 bits (297), Expect = 3e-26
 Identities = 96/374 (25%), Positives = 158/374 (42%), Gaps = 22/374 (5%)

Query: 248  GNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMA 307
            G  V   C   G+P   + W+ +   L L   T L+     TL I   + +D G++ C+A
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHG-SGHTLRISKVQLADAGIFTCVA 2104

Query: 308  RNSAGEAKTQSAMLRYSSLPAKPSFVIQP----QDTEVLIGTSTTLECMATGHPHPLITW 363
             + AG A       R  +L  +   V++P     D  V+ G+   L C A G P PL++W
Sbjct: 2105 ASPAGVAD------RNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW 2158

Query: 364  TRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTV 423
             +D    L  S+ +     L L+ +   D G ++C A +  G  +    + V  PP    
Sbjct: 2159 MKDGEPLL--SQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIED 2216

Query: 424  T--PKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQH 481
            +  P +  +     +E LC+A G P P I W K G  L    ++   ++  LR+      
Sbjct: 2217 SGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-TRLENNSRATRVLRV-----R 2270

Query: 482  DQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPI 541
            D G Y C A S  G  + S ++ V+     V  + P+         + + C  + EP P 
Sbjct: 2271 DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPK 2330

Query: 542  ITWNKEGVQITESGKFHVDDEGT-LTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAI 600
            ITW+++G+ + E       + G  L +      D G Y C ARN+ G       + +  +
Sbjct: 2331 ITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV 2390

Query: 601  QGRQAGDDFVESSI 614
               ++G   V  S+
Sbjct: 2391 PTIRSGPPAVNVSV 2404



 Score =  117 bits (292), Expect = 1e-25
 Identities = 85/279 (30%), Positives = 124/279 (44%), Gaps = 17/279 (6%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMI 292
            P  T  P D  +  G+ ++  C A G+P P I W  N+  +       ++  D G TL  
Sbjct: 2847 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQR 2902

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLI---GTSTTL 349
                  D G Y C A N  G  +TQ+     S +  K + V+Q +    L+   G S  L
Sbjct: 2903 AAVSREDSGTYVCWAENRVG--RTQAV----SFVHVKEAPVLQGEAFSYLVEPVGGSIQL 2956

Query: 350  ECMATGHPHPLITWTRDNGLELDGS--RHVATSSGLYLQNITQRDHGRFTCHANNSHGTV 407
            +C+  G P P I W +D GL L GS  RH   +  L ++   + D GR+ C A N  G  
Sbjct: 2957 DCVVRGDPVPDIHWIKD-GLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVA 3015

Query: 408  QAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV 467
            +    +++Q+ P F V P+D  V     V   C+A G P P I W + G  L    +   
Sbjct: 3016 KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 3075

Query: 468  LSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVK 506
            L  G+L ++     D G Y+C A + LG       L V+
Sbjct: 3076 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114



 Score =  105 bits (263), Expect = 2e-22
 Identities = 99/374 (26%), Positives = 156/374 (41%), Gaps = 39/374 (10%)

Query: 240 PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299
           P  V+  +G  V   C A G+P P + W H    +   +++RL   D   L + +  E+ 
Sbjct: 321 PYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET-DGSVLRLESPGEAS 379

Query: 300 QGVYQCMARNSAGEAKTQSAMLRYS-SLPAKPSFVIQPQDTEV--LIGTSTTLECMATGH 356
            G+Y C+A + AGE     A+L+YS  +   P  ++     +V  ++G    L C A+G 
Sbjct: 380 SGLYSCVASSPAGE-----AVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGS 434

Query: 357 PHPLITWTRDN--GLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANII 414
           P P I W ++     EL G +  +  + L++ ++     G F C A N  GT  A   + 
Sbjct: 435 PVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVS 494

Query: 415 VQ---APPQFTVTPKDQVVLEEHAVEW--LCE--------ADGNPPPVIVWTKTGGQLPV 461
           V    AP    V         EH   +   C+        A   PP V  W   G    +
Sbjct: 495 VHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS---L 551

Query: 462 EGQHTVLSSG-----TLRIDRAAQHDQGQYECQAVSSLGVKK--VSVQLTVKPKALAVFT 514
            G+ T +         L+I++    D+G Y C A +  G  K  V++++ V P       
Sbjct: 552 WGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN----IE 607

Query: 515 QLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFP 573
             P + +V    ++ + C A G P P ++W K    ++      V  +G  L I  A   
Sbjct: 608 PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLS 667

Query: 574 DQGRYECVARNSFG 587
           D G Y CVA N  G
Sbjct: 668 DAGSYRCVASNVAG 681



 Score =  101 bits (252), Expect = 5e-21
 Identities = 79/275 (28%), Positives = 116/275 (42%), Gaps = 13/275 (4%)

Query: 239 EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG--TLMIRNTR 296
           E  +V V   + V   C A G P P I W  +   L         V+  G   L +   +
Sbjct: 226 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKV---VYTRGGRQLQLGRAQ 282

Query: 297 ESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGH 356
            SD GVY C A N+ G A+  + +  Y   P       +P   + + G    LEC+A GH
Sbjct: 283 SSDAGVYTCKASNAVGAAEKATRLDVYVP-PTIEGAGGRPYVVKAVAGRPVALECVARGH 341

Query: 357 PHPLITWTRDNGL---ELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANI 413
           P P ++W  + GL   E + SR     S L L++  +   G ++C A++  G      ++
Sbjct: 342 PSPTLSWHHE-GLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSV 400

Query: 414 IVQAPPQFTVTP--KDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG 471
            VQ PPQ  V         +    +E  C+A G+P P I W + G          V S G
Sbjct: 401 EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG 460

Query: 472 -TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
            TL ID       G + CQA +  G     V+++V
Sbjct: 461 TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 495



 Score =  101 bits (251), Expect = 6e-21
 Identities = 80/270 (29%), Positives = 110/270 (40%), Gaps = 22/270 (8%)

Query: 342 LIGTSTTLECMATGHPHPLITWTRDNGL-----------------ELDGSRHVATSSGLY 384
           + G S TLEC A G P P I W +D  L                 ++ G R +     L+
Sbjct: 31  MAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLH 90

Query: 385 LQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVV--LEEHAVEWLCEA 442
              I + D G ++C A N  GT Q   +++V  PP        Q V  L    VE  C  
Sbjct: 91  FPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWT 150

Query: 443 DGNPPPVIVWTKTGGQLPVEGQHTVLSSG--TLRIDRAAQHDQGQYECQAVSSLGVKKVS 500
            G P P + WTK    +   G H  +      LRI  +   D+G+Y+C A S  G +   
Sbjct: 151 SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD 210

Query: 501 VQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVD 560
            QL V        +    + +V     + + C A+G P P ITW K+G  +  S K    
Sbjct: 211 FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYT 270

Query: 561 DEG-TLTIYDAGFPDQGRYECVARNSFGLA 589
             G  L +  A   D G Y C A N+ G A
Sbjct: 271 RGGRQLQLGRAQSSDAGVYTCKASNAVGAA 300



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 48/178 (26%), Positives = 72/178 (40%), Gaps = 18/178 (10%)

Query: 440 CEADGNPPPVIVWTKTGGQLPVE---------------GQHTVLSSG-TLRIDRAAQHDQ 483
           C+A+G P P IVW K    + V                G H +L  G +L   R  + D 
Sbjct: 40  CDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDS 99

Query: 484 GQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIIT 543
           G Y C+A +  G  +    L V      +     Q+     G ++ + C   G P P + 
Sbjct: 100 GLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVE 159

Query: 544 WNKEGVQITESGK-FHVDDEG-TLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTA 599
           W K+   +   G    V ++G  L I  +   D+GRY+CVA +  G    +  L V A
Sbjct: 160 WTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHA 217



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 31/89 (34%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 233  SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMI 292
            +P    EPQD+ V SG+ V   C+A G P P I W+       L    RL    DG+L +
Sbjct: 3026 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQ--PLRASRRLRTLPDGSLWL 3083

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAML 321
             N    D G Y C+A N  G A  ++ ++
Sbjct: 3084 ENVETGDAGTYDCVAHNLLGSATARAFLV 3112


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  174 bits (440), Expect = 7e-43
 Identities = 122/369 (33%), Positives = 162/369 (43%), Gaps = 14/369 (3%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P I  EP D  V        TC A G P P I W  N   L L       +   G + I 
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL-LPRGDGYRILSSGAIEIL 3955

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE--VLIGTSTTLEC 351
             T+ +  G Y C+ARN+AG A       R+ +L      VIQPQ +E  V++     L C
Sbjct: 3956 ATQLNHAGRYTCVARNAAGSAH------RHVTLHVHEPPVIQPQPSELHVILNNPILLPC 4009

Query: 352  MATGHPHPLITWTRDN-GLELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQA 409
             ATG P P ITW ++   +   G  H V  S GL +    + D G + C A N  GT   
Sbjct: 4010 EATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALG 4069

Query: 410  AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLS 469
               + VQ PP  +   K+ V+  +  +   CEADG PPP I W K G  +    +  VLS
Sbjct: 4070 KIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLS 4129

Query: 470  SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNIN 529
            SG+L+I      D G Y C A +  G    S +LTV        T+     +V       
Sbjct: 4130 SGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTE--GHYTVNENSQAI 4187

Query: 530  ISCHAQGEPQPIITWNKEGVQITE-SGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGL 588
            + C A G P P I W K+ V +    GK+  +  G L + +    D G Y CVA N+ G 
Sbjct: 4188 LPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGE 4247

Query: 589  AVTNMFLTV 597
                + LTV
Sbjct: 4248 DTHTVSLTV 4256



 Score =  173 bits (438), Expect = 1e-42
 Identities = 121/369 (32%), Positives = 171/369 (46%), Gaps = 12/369 (3%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL-EDDTRLNVFDDGTLMI 292
            P I   P ++ V         C A G PKP I W  N H L++ ++     +   G+L+I
Sbjct: 3804 PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVI 3863

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECM 352
             +    D   Y+C   N AG+ K    +    ++   PS   +P D  V       + C 
Sbjct: 3864 ISPSVDDTATYECTVTNGAGDDKRTVDL----TVQVPPSIADEPTDFLVTKHAPAVITCT 3919

Query: 353  ATGHPHPLITWTRDNGLEL--DGSRHVATSSGLYLQNITQRDH-GRFTCHANNSHGTVQA 409
            A+G P P I WT+ NG+ L   G  +   SSG      TQ +H GR+TC A N+ G+   
Sbjct: 3920 ASGVPFPSIHWTK-NGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHR 3978

Query: 410  AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQ-HTVL 468
               + V  PP     P +  V+  + +   CEA G P P I W K G  +   G+ H VL
Sbjct: 3979 HVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVL 4038

Query: 469  SSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNI 528
             SG L+I RA + D G Y C A +  G     ++L V  +   V +   ++  + V K I
Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNV--QVPPVISPHLKEYVIAVDKPI 4096

Query: 529  NISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGL 588
             +SC A G P P ITW+K+G  I ES +  V   G+L I      D G Y C+A N  G 
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS 4156

Query: 589  AVTNMFLTV 597
            + T+  LTV
Sbjct: 4157 SSTSTKLTV 4165



 Score =  167 bits (423), Expect = 7e-41
 Identities = 121/369 (32%), Positives = 173/369 (46%), Gaps = 17/369 (4%)

Query: 237  TFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT-LMIRNT 295
            T EP+D+ V     V   C+++  P P I W+ N   L  +   R+ +   G  L I N 
Sbjct: 3625 TDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERL--QATPRVRILSGGRYLQINNA 3682

Query: 296  RESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATG 355
               D   Y C+A N AG  KT    +   ++P  P+    PQ   +L+  ST LEC+A G
Sbjct: 3683 DLGDTANYTCVASNIAG--KTTREFILTVNVP--PNIKGGPQSLVILLNKSTVLECIAEG 3738

Query: 356  HPHPLITWTRDNG-LELDGSRHVATSSG-LYLQNITQRDHGRFTCHANNSHGTVQAAANI 413
             P P ITW +D   L  + +R+    +G L++Q+    D GR+ C A N+ GT +   ++
Sbjct: 3739 VPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDL 3798

Query: 414  IVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV---EGQHTVLSS 470
             V  PP     P +  V+        CEA G P P I W K G  L V   +  + +LSS
Sbjct: 3799 QVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSS 3858

Query: 471  GTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVK-PKALAVFTQLPQDTSVEVGKNIN 529
            G+L I   +  D   YEC   +  G  K +V LTV+ P ++A     P D  V       
Sbjct: 3859 GSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIA---DEPTDFLVTKHAPAV 3915

Query: 530  ISCHAQGEPQPIITWNKEGVQITESGK-FHVDDEGTLTIYDAGFPDQGRYECVARNSFGL 588
            I+C A G P P I W K G+++   G  + +   G + I        GRY CVARN+ G 
Sbjct: 3916 ITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGS 3975

Query: 589  AVTNMFLTV 597
            A  ++ L V
Sbjct: 3976 AHRHVTLHV 3984



 Score =  167 bits (422), Expect = 9e-41
 Identities = 114/356 (32%), Positives = 165/356 (46%), Gaps = 10/356 (2%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSL-DLEDDTRLNVFDDGTLMI 292
            PRI        V   +     C A+G P P I W  +N  L +L        +  G L++
Sbjct: 4169 PRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPY--GELIL 4226

Query: 293  RNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECM 352
             N    D G Y C+A N+AGE  T +  L    LP   +F   P D  +  G    L C 
Sbjct: 4227 ENVVLEDSGFYTCVANNAAGE-DTHTVSLTVHVLP---TFTELPGDVSLNKGEQLRLSCK 4282

Query: 353  ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAAN 412
            ATG P P +TWT +N +       V   S L ++ +++ D G + C A NS G V+A   
Sbjct: 4283 ATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGF 4342

Query: 413  IIVQAPPQFTVT-PKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG 471
            + V+ PP F    P + +          CE  G+P P I W + G  + +  +   L +G
Sbjct: 4343 VYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNG 4402

Query: 472  TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINIS 531
            +L I      D G Y C A +  GV + S+ LT++     + T  P +T +  G  I ++
Sbjct: 4403 SLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPP--IITLEPVETVINAGGKIILN 4460

Query: 532  CHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
            C A GEPQP ITW+++G  I+   + +V    +L I DA   D   +ECVARN  G
Sbjct: 4461 CQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516



 Score =  164 bits (416), Expect = 4e-40
 Identities = 119/364 (32%), Positives = 178/364 (48%), Gaps = 26/364 (7%)

Query: 241  QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ 300
            +++ V   N +  TC   G P P++ W+ N   + L  +T L V    TL I   + SD 
Sbjct: 2972 ENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNT-LIVPGGRTLQIIRAKVSDG 3030

Query: 301  GVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLI------GTSTTLECMAT 354
            G Y C+A N AGE+K + ++  Y      PS  I+  D+E L       GTS +LEC + 
Sbjct: 3031 GEYTCIAINQAGESKKKFSLTVY----VPPS--IKDHDSESLSVVNVREGTSVSLECESN 3084

Query: 355  GHPHPLITWTRDNGLELDGSRHV---ATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAA 411
              P P+ITW + NG  +  S HV   A    L+++     D G++ C A N  G      
Sbjct: 3085 AVPPPVITWYK-NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNF 3143

Query: 412  NIIVQAPPQFTVTPKDQVVLE--EHAVEWLCEADGNPPPVIVWTKTGGQLPVEG--QHTV 467
            ++ V  PP     P+ +V++E   + V   C+A G PPP I W K   ++      +  +
Sbjct: 3144 HLNVYVPPSIE-GPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRI 3202

Query: 468  LSSGT-LRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGK 526
            LS G+ L+I R+   D G Y C A +  G  +    L+++        ++P D SV +G+
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGE 3262

Query: 527  NINISCHAQGEPQPIITWNKEGVQIT--ESGKFHVDDEG-TLTIYDAGFPDQGRYECVAR 583
            N+ + C+A G P P+I W K+G  I   E+ +  V   G TL IY A   D G+Y CVA 
Sbjct: 3263 NVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVAT 3322

Query: 584  NSFG 587
            N  G
Sbjct: 3323 NPAG 3326



 Score =  164 bits (415), Expect = 6e-40
 Identities = 118/386 (30%), Positives = 172/386 (44%), Gaps = 16/386 (4%)

Query: 221  VASVTVEEFNCQ---SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE 277
            +A  T  EF       P I   PQ + +    +    C AEG P P I W   + ++   
Sbjct: 3697 IAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITW-RKDGAVLAG 3755

Query: 278  DDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQ 337
            +  R ++ ++G L I++   +D G Y CMA N+AG  + +  +     +   PS    P 
Sbjct: 3756 NHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDL----QVHVPPSIAPGPT 3811

Query: 338  DTEVLIGTSTTLECMATGHPHPLITWTRDNGL----ELDGSRHVATSSGLYLQNITQRDH 393
            +  V++   TTL C ATG P P I W ++  L    +   S  + +S  L + + +  D 
Sbjct: 3812 NMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 3871

Query: 394  GRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWT 453
              + C   N  G  +   ++ VQ PP     P D +V +       C A G P P I WT
Sbjct: 3872 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3931

Query: 454  KTGGQLPVEGQ-HTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAV 512
            K G +L   G  + +LSSG + I     +  G+Y C A ++ G     V L V      V
Sbjct: 3932 KNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEP--PV 3989

Query: 513  FTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFH-VDDEGTLTIYDAG 571
                P +  V +   I + C A G P P ITW KEG+ +  SG+ H V   G L I  A 
Sbjct: 3990 IQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAV 4049

Query: 572  FPDQGRYECVARNSFGLAVTNMFLTV 597
              D G Y CVA+N  G A+  + L V
Sbjct: 4050 REDAGTYMCVAQNPAGTALGKIKLNV 4075



 Score =  159 bits (403), Expect = 1e-38
 Identities = 115/371 (30%), Positives = 164/371 (44%), Gaps = 23/371 (6%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P I    Q +    G  V   C+A GNPKP +IW      +      + +   DG+L + 
Sbjct: 981  PTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSS-AKFSAGADGSLYVV 1039

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFV--------IQPQDTEVLIGT 345
            +    + G Y C A N+AG AK +  +  Y     +P            +P +  VL G 
Sbjct: 1040 SPGGEESGEYVCTATNTAGYAKRKVQLTVY----VRPRVFGDQRGLSQDKPVEISVLAGE 1095

Query: 346  STTLECMATGHPHPLITWTRDNGLELDGS-RHVATSSG-LYLQNITQRDHGRFTCHANNS 403
              TL C     P P+ITW ++  L    S RH    SG + +      D G + C A N 
Sbjct: 1096 EVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNI 1155

Query: 404  HGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEG 463
             G V  A  + V  PP+    PK   V     V+  C A G P PVI W+K G  + V+G
Sbjct: 1156 AGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDG 1215

Query: 464  QHTVLS-SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV 522
            +H V +  GTL ID+A   D G Y C A +  G  +  + L V+        + P +T+ 
Sbjct: 1216 EHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTF 1275

Query: 523  E---VGKNINISCHAQGEPQPIITWNKEGVQIT--ESGKFHVDDEGTLTIYDAGFP-DQG 576
            +     + I   C A+G P+P I W   G ++T  E G   + ++GTL +  +  P D G
Sbjct: 1276 QERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPG-ISILEDGTLLVIASVTPYDNG 1334

Query: 577  RYECVARNSFG 587
             Y CVA N  G
Sbjct: 1335 EYICVAVNEAG 1345



 Score =  158 bits (399), Expect = 4e-38
 Identities = 112/359 (31%), Positives = 160/359 (44%), Gaps = 15/359 (4%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
            +P ++ V +G  V   C  +  P P I W      +      R      G++ I  TR S
Sbjct: 1085 KPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLIS-PFSPRHTFLPSGSMKITETRTS 1143

Query: 299  DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
            D G+Y C+A N AG   TQ+  L   ++   P     P+  +V +G    + C A G P 
Sbjct: 1144 DSGMYLCVATNIAGNV-TQAVKL---NVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPL 1199

Query: 359  PLITWTRDNGLEL-DGSRHVATSSG-LYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQ 416
            P+ITW++     L DG  HV+   G L +   T  D G +TC A N  GT +    + VQ
Sbjct: 1200 PVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQ 1259

Query: 417  APPQFT-VTPKDQVVLEEHA----VEWLCEADGNPPPVIVWTKTGGQLPV-EGQHTVLSS 470
             PP    + P      +E      +E+ C A G P P I W   G +L   E   ++L  
Sbjct: 1260 EPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILED 1319

Query: 471  GTLR-IDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNIN 529
            GTL  I     +D G+Y C AV+  G  +    L V    +    +   + SV + +  N
Sbjct: 1320 GTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTN 1379

Query: 530  ISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFG 587
            + C  +G P PII W K+ VQ+TES      + G  L ++ A   D GRY C A N  G
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAG 1438



 Score =  157 bits (397), Expect = 7e-38
 Identities = 108/362 (29%), Positives = 164/362 (45%), Gaps = 19/362 (5%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT-LMIRNTRE 297
            E   + V  GN +   C + G P P +IW      +  +   R+ +   G  L I    +
Sbjct: 2202 ELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEK 2261

Query: 298  SDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHP 357
            SD  +Y C+A N AG AK +  +  Y   P   +    P +  V  G S +LEC   G P
Sbjct: 2262 SDAALYSCVASNVAGTAKKEYNLQVYIR-PTITNSGSHPTEIIVTRGKSISLECEVQGIP 2320

Query: 358  HPLITWTRDN-------GLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAA 410
             P +TW +D        G+E+    H+     L L+NI   D GR+ C A N  G     
Sbjct: 2321 PPTVTWMKDGHPLIKAKGVEILDEGHI-----LQLKNIHVSDTGRYVCVAVNVAGMTDKK 2375

Query: 411  ANIIVQAPPQFTV---TPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV 467
             ++ V APP       +P++  V+E+++V   CEA G P P I W K G  + +     +
Sbjct: 2376 YDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRI 2435

Query: 468  LSSGT-LRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGK 526
            LS G  LR+ +    D GQY C   ++ G ++    L+V      V     +D  V+  +
Sbjct: 2436 LSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQ 2495

Query: 527  NINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGT-LTIYDAGFPDQGRYECVARNS 585
            ++ ++C   G P P ITW+K+G  + E    H+   G  L I +   P  GRY C+A + 
Sbjct: 2496 SVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSP 2555

Query: 586  FG 587
             G
Sbjct: 2556 AG 2557



 Score =  157 bits (396), Expect = 9e-38
 Identities = 105/350 (30%), Positives = 156/350 (44%), Gaps = 12/350 (3%)

Query: 251  VYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNS 310
            +  +C A+G P P+I W  +  ++   +  R  V   G+L I   +  D G Y CMA N 
Sbjct: 4096 ITLSCEADGLPPPDITWHKDGRAI--VESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANV 4153

Query: 311  AGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL- 369
            AG + T + +    ++   P          V   +   L C+A G P P I W +DN L 
Sbjct: 4154 AGSSSTSTKL----TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLL 4209

Query: 370  -ELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQ 428
              L G         L L+N+   D G +TC ANN+ G      ++ V   P FT  P D 
Sbjct: 4210 ANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDV 4269

Query: 429  VVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYEC 488
             + +   +   C+A G P P + WT     +P     +V     L I+R ++ D G Y C
Sbjct: 4270 SLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFD-SVNGHSELVIERVSKEDSGTYVC 4328

Query: 489  QAVSSLG-VKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKE 547
             A +S+G VK +      +P         P +    +G N  ++C  +G+P P I WN++
Sbjct: 4329 TAENSVGFVKAIGFVYVKEPPVFK--GDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRK 4386

Query: 548  GVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
            GV I  S +      G+L IY     D G Y CVA N  G+   +M LT+
Sbjct: 4387 GVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTL 4436



 Score =  156 bits (394), Expect = 2e-37
 Identities = 106/392 (27%), Positives = 173/392 (44%), Gaps = 21/392 (5%)

Query: 218 GRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE 277
           GRA     V E     P +   P +V V  G     TC         + W  N+  + L 
Sbjct: 508 GRAQTFFDVSE----PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLA 563

Query: 278 DDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQ 337
           +  R+    + +L +++ + +D G Y CM  +  G     SA   + ++   P   + P+
Sbjct: 564 EPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGG----SSAASVFLTVQEPPKVTVMPK 619

Query: 338 DTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSG-LYLQNITQRDHGRF 396
           +     G+  ++ C ATG+P P I WT ++   +   R+  TS G L+++N   +D G +
Sbjct: 620 NQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIY 679

Query: 397 TCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTG 456
            C A+NS GT +  + +     P+  V   + +V         C+  G PPP + W K  
Sbjct: 680 GCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFK-- 737

Query: 457 GQLPVEGQHTVLSS---GTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVF 513
           G L +     ++     G L+I      D G Y C A++  G  + + ++T+   +  VF
Sbjct: 738 GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG--RATGKITLDVGSPPVF 795

Query: 514 TQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDD-----EGTLTIY 568
            Q P D S+E+G N+ + C+ QG P+P I W +       S  F V        G L I 
Sbjct: 796 IQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFIL 855

Query: 569 DAGFPDQGRYECVARNSFGLAVTNMFLTVTAI 600
           +    D+G Y C A N FG   +   +TVT +
Sbjct: 856 NLWASDKGTYICEAENQFGKIQSETTVTVTGL 887



 Score =  155 bits (392), Expect = 3e-37
 Identities = 109/396 (27%), Positives = 181/396 (45%), Gaps = 20/396 (5%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P+I   P+ ++V  G  V   C A+G P P I W     ++ ++ +  ++   DGTL I 
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSN-PDGTLSID 1229

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDT---EVLIGTSTTLE 350
                SD G+Y C+A N AG  +T+  +  +   P     +  P +T   E +        
Sbjct: 1230 QATPSDAGIYTCVATNIAGTDETEITL--HVQEPPTVEDLEPPYNTTFQERVANQRIEFP 1287

Query: 351  CMATGHPHPLITWTRDNGLELDGSRH----VATSSGLYLQNITQRDHGRFTCHANNSHGT 406
            C A G P P I W   NG EL G       +   + L + ++T  D+G + C A N  GT
Sbjct: 1288 CPAKGTPKPTIKWLH-NGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT 1346

Query: 407  VQAAANIIVQAPPQFTVTPKDQV----VLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
             +   N+ V  PP   +  K+QV    VL        CE +G P P+I+W K   Q+   
Sbjct: 1347 TERKYNLKVHVPP--VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTES 1404

Query: 463  GQHTVLSSGT-LRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTS 521
                 +++G  L++ RA   D G+Y C+A++  G  +    + V      + T  P + S
Sbjct: 1405 STIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVS 1464

Query: 522  VEVGKNINISCHAQGEPQPIITWNKEG--VQITESGKFHVDDEGTLTIYDAGFPDQGRYE 579
            V + +++ + C  +G P P I W K+G  + + +     +D    L + +A   D+GRY+
Sbjct: 1465 VVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQ 1524

Query: 580  CVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSIL 615
            C   N+ G    ++ LT+      + G+   + S+L
Sbjct: 1525 CTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVL 1560



 Score =  154 bits (390), Expect = 5e-37
 Identities = 111/383 (28%), Positives = 180/383 (46%), Gaps = 27/383 (7%)

Query: 233  SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM- 291
            +P I+     V V   N V   C A G P P + W+ +   +       L V   G ++ 
Sbjct: 2011 APSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVS-SFSNGLQVLSGGRILA 2069

Query: 292  IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351
            + + + SD G Y C+A N+AGE +    +  Y      P+ + + Q+  VLI  +  L C
Sbjct: 2070 LTSAQISDTGRYTCVAVNAAGEKQRDIDLRVY----VPPNIMGEEQNVSVLISQAVELLC 2125

Query: 352  MATGHPHPLITWTRDN-------GLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSH 404
             +   P P +TW +D        GL +  +R V     L +++   +D GR+TC A N  
Sbjct: 2126 QSDAIPPPTLTWLKDGHPLLKKPGLSISENRSV-----LKIEDAQVQDTGRYTCEATNVA 2180

Query: 405  GTVQAAANIIVQAPPQFTVTPK--DQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
            G  +   N+ +  PP    + +     V+E + +  LCE+ G PPP ++W K G  +  +
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTD 2240

Query: 463  --GQHTVLSSG-TLRIDRAAQHDQGQYECQA--VSSLGVKKVSVQLTVKPKALAVFTQLP 517
              G+  +LS G  L+I  A + D   Y C A  V+    K+ ++Q+ ++P  +      P
Sbjct: 2241 SMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRP-TITNSGSHP 2299

Query: 518  QDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQG 576
             +  V  GK+I++ C  QG P P +TW K+G  + ++    + DEG  L + +    D G
Sbjct: 2300 TEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTG 2359

Query: 577  RYECVARNSFGLAVTNMFLTVTA 599
            RY CVA N  G+      L+V A
Sbjct: 2360 RYVCVAVNVAGMTDKKYDLSVHA 2382



 Score =  152 bits (383), Expect = 3e-36
 Identities = 110/368 (29%), Positives = 166/368 (45%), Gaps = 14/368 (3%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMIRNTRE 297
            E +DV +   N +   C     P P + W  + H L   D  ++ +   G  L I   + 
Sbjct: 2785 EAKDVII--NNPISLYCETNAAPPPTLTWYKDGHPLTSSD--KVLILPGGRVLQIPRAKV 2840

Query: 298  SDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHP 357
             D G Y C+A N AGE   Q  +        K +    P++  VL+  S  +EC+++G P
Sbjct: 2841 EDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSP 2900

Query: 358  HPLITWTRDNGLELDGSRHVATSSGLYLQ--NITQRDHGRFTCHANNSHGTVQAAANIIV 415
             P  +W +D    L+   H   S+G  LQ  N    D GR+ C A N+ G+ +   N+ V
Sbjct: 2901 APRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNV 2960

Query: 416  QAPPQFTVTPKDQ--VVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG-T 472
              PP   + PK +   V+  + +   CE  G PPP + W K    + +     ++  G T
Sbjct: 2961 HVPPS-VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRT 3019

Query: 473  LRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINI 530
            L+I RA   D G+Y C A++  G   KK S+ + V P      ++     +V  G ++++
Sbjct: 3020 LQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSL 3079

Query: 531  SCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFGLA 589
             C +   P P+ITW K G  ITES    +  +G  L I  A   D G+Y C A N  G  
Sbjct: 3080 ECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRD 3139

Query: 590  VTNMFLTV 597
              N  L V
Sbjct: 3140 DKNFHLNV 3147



 Score =  151 bits (382), Expect = 4e-36
 Identities = 118/423 (27%), Positives = 188/423 (44%), Gaps = 20/423 (4%)

Query: 218  GRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE 277
            GRA   +T++  +   P    EP DV +  G+ V   C  +G P+P I W   ++     
Sbjct: 779  GRATGKITLDVGS--PPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFS 836

Query: 278  DD---TRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVI 334
                 + ++    G L I N   SD+G Y C A N  G+ ++++ +   + L A P   I
Sbjct: 837  RPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVT-VTGLVA-PLIGI 894

Query: 335  QPQDTEVLIGTSTTLEC-MATGHPHPLITWTRDNGLELDGSRHVATSSG-LYLQNITQRD 392
             P    V+ G   TL C +  G+P P   W +++ + L        S G L+++ +  +D
Sbjct: 895  SPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQD 954

Query: 393  HGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVW 452
             G +TC A+N  GT     +++V   P      +    +E   V   C+A GNP P ++W
Sbjct: 955  GGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIW 1014

Query: 453  TKTGGQLPV-EGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLT--VKPKA 509
            +K G  +     + +  + G+L +      + G+Y C A ++ G  K  VQLT  V+P+ 
Sbjct: 1015 SKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRV 1074

Query: 510  LAVFTQLPQDTSVEV----GKNINISCHAQGEPQPIITWNKEGVQITESGKFHVD-DEGT 564
                  L QD  VE+    G+ + + C  +  P PIITW KE   I+     H     G+
Sbjct: 1075 FGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGS 1134

Query: 565  LTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSA 624
            + I +    D G Y CVA N  G     + L V      Q G   ++   +   QRVD  
Sbjct: 1135 MKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLK---VQVGQRVDIP 1191

Query: 625  INS 627
             N+
Sbjct: 1192 CNA 1194



 Score =  151 bits (381), Expect = 5e-36
 Identities = 115/370 (31%), Positives = 154/370 (41%), Gaps = 14/370 (3%)

Query: 232  QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM 291
            + P I  +P ++ V   N +   C A G P P I W     +++        V   G L 
Sbjct: 3986 EPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHA-VLPSGGLQ 4044

Query: 292  IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTS--TTL 349
            I      D G Y C+A+N AG A      L    L  +   VI P   E +I      TL
Sbjct: 4045 ISRAVREDAGTYMCVAQNPAGTA------LGKIKLNVQVPPVISPHLKEYVIAVDKPITL 4098

Query: 350  ECMATGHPHPLITWTRDNGLELDGSRHVATSSG-LYLQNITQRDHGRFTCHANNSHGTVQ 408
             C A G P P ITW +D    ++  R    SSG L +  +   D G +TC A N  G+  
Sbjct: 4099 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158

Query: 409  AAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLP-VEGQHTV 467
             +  + V  PP+   T     V E       C ADG P P I W K    L  + G++T 
Sbjct: 4159 TSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA 4218

Query: 468  LSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKN 527
               G L ++     D G Y C A ++ G    +V LTV    L  FT+LP D S+  G+ 
Sbjct: 4219 EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV--HVLPTFTELPGDVSLNKGEQ 4276

Query: 528  INISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
            + +SC A G P P +TW      I  +    V+    L I      D G Y C A NS G
Sbjct: 4277 LRLSCKATGIPLPKLTWTFNN-NIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVG 4335

Query: 588  LAVTNMFLTV 597
                  F+ V
Sbjct: 4336 FVKAIGFVYV 4345



 Score =  147 bits (370), Expect = 1e-34
 Identities = 108/378 (28%), Positives = 160/378 (42%), Gaps = 14/378 (3%)

Query: 249  NTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT-LMIRNTRESDQGVYQCMA 307
            N V  TC A G P P I W+ N+  ++  D   + +   G+ L I  ++ SD G Y C+A
Sbjct: 3167 NPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIA 3226

Query: 308  RNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDN 367
             N  G+A  Q        +P   +    P D  VL+G +  L C A G P PLI W +D 
Sbjct: 3227 SNMEGKA--QKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDG 3284

Query: 368  ----GLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTV 423
                  E +  R  A  S L +      D G++TC A N  G      N+ V   P    
Sbjct: 3285 KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRG 3344

Query: 424  TPKDQ----VVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG-TLRIDRA 478
              KD+    + L + ++   C A G PPP I W K G  LP+     +L++G  +RI RA
Sbjct: 3345 N-KDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRA 3403

Query: 479  AQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEP 538
               D   Y C A +  GV      L V        +   ++ +V  G + +++C   G P
Sbjct: 3404 QVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTP 3463

Query: 539  QPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
             P + W ++G  +       V   G  L +  A   D G+Y C+A N  G    +  L V
Sbjct: 3464 APSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKV 3523

Query: 598  TAIQGRQAGDDFVESSIL 615
                     ++  E S++
Sbjct: 3524 LEPPHINGSEEHEEISVI 3541



 Score =  145 bits (366), Expect = 3e-34
 Identities = 118/358 (32%), Positives = 167/358 (46%), Gaps = 32/358 (8%)

Query: 249  NTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM-IRNTRESDQGVYQCMA 307
            N V   C+A GNP P I W  +N  L     T +   + G ++ I + + SD G+Y+C+A
Sbjct: 1936 NPVQLECKAAGNPVPVITWYKDNRLLS--GSTSMTFLNRGQIIDIESAQISDAGIYKCVA 1993

Query: 308  RNSAGEAKTQSAMLRYS-SLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRD 366
             NSAG  +     L YS  +   PS         V++     LEC A G P P +TW +D
Sbjct: 1994 INSAGATE-----LFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKD 2048

Query: 367  --------NGLE-LDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
                    NGL+ L G R +A +S          D GR+TC A N+ G  Q   ++ V  
Sbjct: 2049 GSPVSSFSNGLQVLSGGRILALTSAQI------SDTGRYTCVAVNAAGEKQRDIDLRVYV 2102

Query: 418  PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQ-LPVEGQHTVLSSGTLRID 476
            PP      ++  VL   AVE LC++D  PPP + W K G   L   G     +   L+I+
Sbjct: 2103 PPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIE 2162

Query: 477  RAAQHDQGQYECQAVSSLG--VKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHA 534
             A   D G+Y C+A +  G   K  +V + V P  +    +L Q T +E G  I++ C +
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPN-IGGSDELTQLTVIE-GNLISLLCES 2220

Query: 535  QGEPQPIITWNKEGVQI-TES-GKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFGLA 589
             G P P + W K+G  + T+S G+  +   G  L I  A   D   Y CVA N  G A
Sbjct: 2221 SGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTA 2278



 Score =  144 bits (363), Expect = 6e-34
 Identities = 105/368 (28%), Positives = 157/368 (42%), Gaps = 17/368 (4%)

Query: 239  EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
            E +++ V   N +  TC A G P P++ W+ +   L   D  +  +     L I   +  
Sbjct: 3534 EHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQ-TLGGGEVLRISTAQVE 3592

Query: 299  DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
            D G Y C+A + AG+       L    +P   +   +P+D  VL     TLEC +   P 
Sbjct: 3593 DTGRYTCLASSPAGD--DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPP 3650

Query: 359  PLITWTRDNGLELDGSRHVATSSG---LYLQNITQRDHGRFTCHANNSHGTVQAAANIIV 415
            P+ITW R NG  L  +  V   SG   L + N    D   +TC A+N  G       + V
Sbjct: 3651 PVITWLR-NGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTV 3709

Query: 416  QAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLP-VEGQHTVLSSGTLR 474
              PP     P+  V+L   +    C A+G P P I W K G  L     ++++L +G L 
Sbjct: 3710 NVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLH 3769

Query: 475  IDRAAQHDQGQYECQAVSSLGV--KKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISC 532
            I  A   D G+Y C A ++ G   +++ +Q+ V P         P + +V V     ++C
Sbjct: 3770 IQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPS----IAPGPTNMTVIVNVQTTLAC 3825

Query: 533  HAQGEPQPIITWNKEGVQIT---ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLA 589
             A G P+P I W K G  +        + +   G+L I      D   YEC   N  G  
Sbjct: 3826 EATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDD 3885

Query: 590  VTNMFLTV 597
               + LTV
Sbjct: 3886 KRTVDLTV 3893



 Score =  143 bits (361), Expect = 1e-33
 Identities = 114/382 (29%), Positives = 166/382 (43%), Gaps = 24/382 (6%)

Query: 218 GRAVASV--TVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLD 275
           G + ASV  TV+E     P++T  P++     G+ V   C A G PKP+I W  N+  + 
Sbjct: 598 GSSAASVFLTVQE----PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVND--MF 651

Query: 276 LEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQ 335
           +    R  +  DGTL I+N    D G+Y C+A NSAG  K Q++ LRY      P  ++ 
Sbjct: 652 IVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDK-QNSTLRYIE---APKLMVV 707

Query: 336 PQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR---D 392
             +  V +G  T +EC  +G P P + W + + LEL  S  +     L L  I +    D
Sbjct: 708 QSELLVALGDITVMECKTSGIPPPQVKWFKGD-LELRPSTFLIIDPLLGLLKIQETQDLD 766

Query: 393 HGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVW 452
            G +TC A N  G       + V +PP F   P D  +     V   C   G P P I W
Sbjct: 767 AGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW 826

Query: 453 TKTGGQLPVEGQHTVLSS------GTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVK 506
            +    +P+  +   +SS      G L I      D+G Y C+A +  G  +    +TV 
Sbjct: 827 RRL-DNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVT 885

Query: 507 PKALAVFTQLPQDTSVEVGKNINISCH-AQGEPQPIITWNKEGVQITESGKFHVDDEGTL 565
                +    P   +V  G+ + + C    G P P   W K    + ++    V  +G+L
Sbjct: 886 GLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSL 945

Query: 566 TIYDAGFPDQGRYECVARNSFG 587
            I      D G Y CVA N  G
Sbjct: 946 HIERVQLQDGGEYTCVASNVAG 967



 Score =  143 bits (360), Expect = 1e-33
 Identities = 107/374 (28%), Positives = 162/374 (43%), Gaps = 27/374 (7%)

Query: 240  PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMIRNTRES 298
            P+DV V   +     C A   P   I W  +     LE +  + +   G TL I N +E 
Sbjct: 2582 PEDVTVILNSPTSLVCEAYSYPPATITWFKD--GTPLESNRNIRILPGGRTLQILNAQED 2639

Query: 299  DQGVYQCMARNSAGE-AKTQSAMLRYSSLPAKPSF---VIQPQDTEVLIGTSTTLECMAT 354
            + G Y C+A N AGE  K     +    +  K       + P++ ++ +  + TLEC A 
Sbjct: 2640 NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699

Query: 355  GHPHPLITWTRDNGLELDGSRHV---ATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAA 411
              P   ++W +D G  L    HV   A    L ++     D GR+TC A+N  G  +   
Sbjct: 2700 AIPSASLSWYKD-GQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDF 2758

Query: 412  NIIVQAPPQFTV------------TPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL 459
            ++ +Q PP F                + + V+  + +   CE +  PPP + W K G  L
Sbjct: 2759 DVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818

Query: 460  PVEGQHTVLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKV--SVQLTVKPKALAVFTQL 516
                +  +L  G  L+I RA   D G+Y C AV+  G   +   V++ V P      + L
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDL 2878

Query: 517  PQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQ 575
            P++ +V V K+  I C + G P P  +W K+G  + E         G  L I +    D 
Sbjct: 2879 PEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDI 2938

Query: 576  GRYECVARNSFGLA 589
            GRY CVA N+ G A
Sbjct: 2939 GRYVCVAENTAGSA 2952



 Score =  141 bits (355), Expect = 5e-33
 Identities = 108/357 (30%), Positives = 163/357 (45%), Gaps = 12/357 (3%)

Query: 240  PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMIRNTRES 298
            P DV V  G  V   C A G P P I W+ +   +   +  R+ V  +G TL I     S
Sbjct: 3253 PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTS 3312

Query: 299  DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
            D G Y C+A N AGE + +   L     P       + +    L+ TS  +EC ATG P 
Sbjct: 3313 DTGKYTCVATNPAGE-EDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371

Query: 359  PLITWTRDNGLELDGSRHV---ATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIV 415
            P I W + NGL L  S H+   A    + +      D   +TC A+N  G      N+ V
Sbjct: 3372 PQINWLK-NGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQV 3430

Query: 416  QAPPQF--TVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG-T 472
             APP    ++  ++  VL+  +    C  DG P P + W + G  L ++   TV + G  
Sbjct: 3431 FAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMV 3490

Query: 473  LRIDRAAQHDQGQYECQAVSSLG-VKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINIS 531
            L++ +A   D G+Y C A +  G V K  +   ++P  +   ++  ++ SV V   + ++
Sbjct: 3491 LQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHIN-GSEEHEEISVIVNNPLELT 3549

Query: 532  CHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFG 587
            C A G P P +TW K+G  + ++ +      G  L I  A   D GRY C+A +  G
Sbjct: 3550 CIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAG 3606



 Score =  133 bits (334), Expect = 1e-30
 Identities = 102/374 (27%), Positives = 163/374 (43%), Gaps = 15/374 (4%)

Query: 251  VYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNS 310
            V   C A G P P I W+ ++  ++              L I  T   D G Y C+A N+
Sbjct: 1844 VALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903

Query: 311  AGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLE 370
            AGE + Q   L     P+         +T VL+     LEC A G+P P+ITW +DN L 
Sbjct: 1904 AGETQ-QHIQLHVHEPPSLEDAGKMLNET-VLVSNPVQLECKAAGNPVPVITWYKDNRL- 1960

Query: 371  LDGSRHVA---TSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKD 427
            L GS  +        + +++    D G + C A NS G  +   ++ V   P  + +   
Sbjct: 1961 LSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNM 2020

Query: 428  QVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL-PVEGQHTVLSSGTLRIDRAAQ-HDQGQ 485
              V+  + V   CEA G P P + W K G  +        VLS G +    +AQ  D G+
Sbjct: 2021 VAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGR 2080

Query: 486  YECQAVSSLGVKK--VSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIIT 543
            Y C AV++ G K+  + +++ V P  +       Q+ SV + + + + C +   P P +T
Sbjct: 2081 YTCVAVNAAGEKQRDIDLRVYVPPNIMGE----EQNVSVLISQAVELLCQSDAIPPPTLT 2136

Query: 544  WNKEGVQITESGKFHV-DDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQG 602
            W K+G  + +     + ++   L I DA   D GRY C A N  G    N  + +     
Sbjct: 2137 WLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPN 2196

Query: 603  RQAGDDFVESSILD 616
                D+  + ++++
Sbjct: 2197 IGGSDELTQLTVIE 2210



 Score =  132 bits (333), Expect = 2e-30
 Identities = 103/368 (27%), Positives = 170/368 (46%), Gaps = 19/368 (5%)

Query: 240  PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299
            P + +V   +++   C+A GNP P + W+ +   +   D+ R+       L I + +E D
Sbjct: 1648 PLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEA-GGKKLEIMSAQEID 1706

Query: 300  QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE---VLIGTSTTLECMATGH 356
            +G Y C+A + AGE +     ++Y      P  +    +T    V++     L+C  TG 
Sbjct: 1707 RGQYICVATSVAGEKE-----IKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGS 1761

Query: 357  PHPLITWTRDNGL--ELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANII 414
            P P I W +D  L  E DG + +     L +      + G + C A N+ G  +    + 
Sbjct: 1762 PPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVT 1821

Query: 415  VQAPPQFTVTP-KDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL-PVEGQHTVLSSG- 471
            V  PP    +   ++VV++   V   C A+G P P I W K    +   +G   + SSG 
Sbjct: 1822 VHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGR 1881

Query: 472  TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKALAVFTQLPQDTSVEVGKNINI 530
             L+I +    D G+Y C A ++ G  +  +QL V +P +L    ++  +T V V   + +
Sbjct: 1882 VLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNET-VLVSNPVQL 1940

Query: 531  SCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFGLA 589
             C A G P P+ITW K+   ++ S      + G  + I  A   D G Y+CVA NS G  
Sbjct: 1941 ECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAG-- 1998

Query: 590  VTNMFLTV 597
             T +F ++
Sbjct: 1999 ATELFYSL 2006



 Score =  131 bits (329), Expect = 5e-30
 Identities = 97/354 (27%), Positives = 155/354 (43%), Gaps = 12/354 (3%)

Query: 242  DVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQG 301
            D+ V   + +   C   G P P I W  +   + +     L +     L I   + SD  
Sbjct: 1556 DISVLINSLIKLECETRGLPMPAITWYKDGQPI-MSSSQALYIDKGQYLHIPRAQVSDSA 1614

Query: 302  VYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLI 361
             Y C   N AG A+    +  Y   P     +  P + +V+I  S TLEC A G+P P++
Sbjct: 1615 TYTCHVANVAGTAEKSFHVDVYVP-PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPIL 1673

Query: 362  TWTRDNGLELDGSRHVATSSG---LYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAP 418
            TW +D G+ +  + ++   +G   L + +  + D G++ C A +  G  +    + V  P
Sbjct: 1674 TWLKD-GVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVP 1732

Query: 419  PQFTVTPKDQ--VVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV-EGQHTVLSSGTLRI 475
            P      +    +V+  + +E  C   G+PPP I+W K G  +   +G   +L+   L I
Sbjct: 1733 PAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVI 1792

Query: 476  DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQ 535
             +A   + G Y C A ++ G  K   ++TV        + L +   V+  K + + C A 
Sbjct: 1793 AQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKY-KPVALQCIAN 1851

Query: 536  GEPQPIITWNKEGVQI-TESGKFHVDDEG-TLTIYDAGFPDQGRYECVARNSFG 587
            G P P ITW K+   + T  G   +   G  L I      D GRY CVA N+ G
Sbjct: 1852 GIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAG 1905



 Score =  131 bits (329), Expect = 5e-30
 Identities = 106/372 (28%), Positives = 164/372 (44%), Gaps = 28/372 (7%)

Query: 241  QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ 300
            +DV+V    +V  TC   GNP PEI W  +   L  ED+    +     L I N +    
Sbjct: 2487 EDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ-EDEAHHIISGGRFLQITNVQVPHT 2545

Query: 301  GVYQCMARNSAGEAKTQSAMLRYSSLP--AKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
            G Y C+A + AG  K++S  L     P  A       P+D  V++ + T+L C A  +P 
Sbjct: 2546 GRYTCLASSPAGH-KSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPP 2604

Query: 359  PLITWTRDNGLELDGSRHVATSSG---LYLQNITQRDHGRFTCHANNSHGTVQAAANIIV 415
              ITW +D G  L+ +R++    G   L + N  + + GR++C A N  G +     + V
Sbjct: 2605 ATITWFKD-GTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKV 2663

Query: 416  QAPPQFT--------VTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTV 467
              PP           ++PK+  +   + +   CEA   P   + W K G  L  +    +
Sbjct: 2664 YIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNI 2723

Query: 468  LSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVK-PKALAVFTQLPQ--DT--- 520
             ++G TL+I  A   D G+Y C A +  G  ++   + ++ P +     ++    DT   
Sbjct: 2724 AANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRN 2783

Query: 521  ----SVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQ 575
                 V +   I++ C     P P +TW K+G  +T S K  +   G  L I  A   D 
Sbjct: 2784 GEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDA 2843

Query: 576  GRYECVARNSFG 587
            GRY CVA N  G
Sbjct: 2844 GRYTCVAVNEAG 2855



 Score =  126 bits (316), Expect = 2e-28
 Identities = 99/364 (27%), Positives = 158/364 (43%), Gaps = 13/364 (3%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P I  E Q+V V     V   C+++  P P + W+ + H L  +    ++  +   L I 
Sbjct: 2104 PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISE-NRSVLKIE 2162

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMA 353
            + +  D G Y C A N AG  KT+        +P       +     V+ G   +L C +
Sbjct: 2163 DAQVQDTGRYTCEATNVAG--KTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCES 2220

Query: 354  TGHPHPLITWTRDNGLEL-DGSRHVATSSG---LYLQNITQRDHGRFTCHANNSHGTVQA 409
            +G P P + W +     L D    V   SG   L +    + D   ++C A+N  GT + 
Sbjct: 2221 SGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKK 2280

Query: 410  AANIIVQAPPQFTVT---PKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHT 466
              N+ V   P  T +   P + +V    ++   CE  G PPP + W K G  L       
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE 2340

Query: 467  VLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKALAVFTQLPQDTSVEV 524
            +L  G  L++      D G+Y C AV+  G+      L+V  P ++    + P++ SV  
Sbjct: 2341 ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVE 2400

Query: 525  GKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-TLTIYDAGFPDQGRYECVAR 583
              +++++C A G P P ITW K+G  ++ S    +   G  L +      D G+Y CV R
Sbjct: 2401 KNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVR 2460

Query: 584  NSFG 587
            N+ G
Sbjct: 2461 NAAG 2464



 Score =  124 bits (310), Expect = 9e-28
 Identities = 87/312 (27%), Positives = 137/312 (43%), Gaps = 15/312 (4%)

Query: 234  PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
            P  T  P DV +  G  +  +C+A G P P++ W  NN+ +    D+   V     L+I 
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS---VNGHSELVIE 4316

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAK---PSFVIQPQDTEVLIGTSTTLE 350
               + D G Y C A NS G  K    +        K   PS  I+P      +G +  L 
Sbjct: 4317 RVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEP------LGGNAILN 4370

Query: 351  CMATGHPHPLITWTRDNGLELDGSRHVAT--SSGLYLQNITQRDHGRFTCHANNSHGTVQ 408
            C   G P P I W R  G++++ S  +    +  L +      D G +TC A N  G V+
Sbjct: 4371 CEVKGDPTPTIQWNR-KGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVE 4429

Query: 409  AAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVL 468
             + ++ +Q+PP  T+ P + V+     +   C+A G P P I W++ G  +  + +  VL
Sbjct: 4430 RSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVL 4489

Query: 469  SSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNI 528
            S+ +L I  A + D  ++EC A + +G   V V + V+           +  SV  GK I
Sbjct: 4490 SNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGI 4549

Query: 529  NISCHAQGEPQP 540
                    +P P
Sbjct: 4550 QKRSRLCNQPLP 4561



 Score =  120 bits (301), Expect = 1e-26
 Identities = 91/306 (29%), Positives = 136/306 (44%), Gaps = 14/306 (4%)

Query: 298 SDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHP 357
           SD+G Y+C+A +SAG  + Q+    +  +   P  +  P +  V  G    L C+     
Sbjct: 492 SDEGFYECIAVSSAGTGRAQT----FFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAV 547

Query: 358 HPLITWTR-DNGLELDGSRHVATSSGLYLQ--NITQRDHGRFTCHANNSHGTVQAAANII 414
              +TW R D  + L     + T + L L+  ++   D G + C  ++  G+  A+  + 
Sbjct: 548 DYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLT 607

Query: 415 VQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLR 474
           VQ PP+ TV PK+Q       V  +C A G P P I WT     +    ++ + S GTL 
Sbjct: 608 VQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLF 667

Query: 475 IDRAAQHDQGQYECQAVSSLGVKKVSVQLTV--KPKALAVFTQLPQDTSVEVGKNINISC 532
           I  AA  D G Y C A +S G  K +  L     PK + V ++L     V +G    + C
Sbjct: 668 IKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSEL----LVALGDITVMEC 723

Query: 533 HAQGEPQPIITWNKEGVQITESGKFHVDD-EGTLTIYDAGFPDQGRYECVARNSFGLAVT 591
              G P P + W K  +++  S    +D   G L I +    D G Y CVA N  G A  
Sbjct: 724 KTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATG 783

Query: 592 NMFLTV 597
            + L V
Sbjct: 784 KITLDV 789



 Score =  119 bits (297), Expect = 3e-26
 Identities = 108/380 (28%), Positives = 160/380 (42%), Gaps = 30/380 (7%)

Query: 240  PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG-TLMIRNTRES 298
            P++V++   NT+   C A   P   + W  +     L+ D  +N+  +G TL I+  + S
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQ--PLKSDDHVNIAANGHTLQIKEAQIS 2738

Query: 299  DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSF-----VIQPQDT-------EVLIGTS 346
            D G Y C+A N AGE +    +    ++   PSF     +    DT       +V+I   
Sbjct: 2739 DTGRYTCVASNIAGEDELDFDV----NIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNP 2794

Query: 347  TTLECMATGHPHPLITWTRDNGLELDGSRHVATSSG---LYLQNITQRDHGRFTCHANNS 403
             +L C     P P +TW +D G  L  S  V    G   L +      D GR+TC A N 
Sbjct: 2795 ISLYCETNAAPPPTLTWYKD-GHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNE 2853

Query: 404  HGTVQAAANIIVQAPPQF----TVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL 459
             G      ++ V  PP      +  P++  VL   +    C + G+P P   W K G  L
Sbjct: 2854 AGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL 2913

Query: 460  PVEGQHTVLSSG-TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQ 518
              +  H  LS+G  L+I      D G+Y C A ++ G  K    L V     +V     +
Sbjct: 2914 LEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPP-SVIGPKSE 2972

Query: 519  DTSVEVGKNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGR 577
            + +V V   I+++C   G P P ++W K    I   +    V    TL I  A   D G 
Sbjct: 2973 NLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGE 3032

Query: 578  YECVARNSFGLAVTNMFLTV 597
            Y C+A N  G +     LTV
Sbjct: 3033 YTCIAINQAGESKKKFSLTV 3052



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 66/235 (28%), Positives = 101/235 (42%), Gaps = 10/235 (4%)

Query: 367 NGLELDGSRHVATSSGLYLQ--NITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVT 424
           NG+ L   +++  S+ + L    +T  D G + C A +S GT +A     V  PP     
Sbjct: 466 NGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQV 525

Query: 425 PKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGG--QLPVEGQHTVLSSGTLRIDRAAQHD 482
           P +  V         C         + W +     +L    +   L++ +L +     +D
Sbjct: 526 PNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFND 585

Query: 483 QGQYECQAVSSLGVKKVSVQLTVK--PKALAVFTQLPQDTSVEVGKNINISCHAQGEPQP 540
            G+Y C   S  G    SV LTV+  PK     T +P++ S   G  ++I C A G P+P
Sbjct: 586 AGEYHCMVSSEGGSSAASVFLTVQEPPKV----TVMPKNQSFTGGSEVSIMCSATGYPKP 641

Query: 541 IITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFL 595
            I W    + I  S ++ +  +GTL I +A   D G Y C+A NS G    N  L
Sbjct: 642 KIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 41/160 (25%), Positives = 67/160 (41%), Gaps = 4/160 (2%)

Query: 440 CEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKV 499
           C  D   P  + + + G  L V+      +S  L I +    D+G YEC AVSS G  + 
Sbjct: 451 CSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRA 510

Query: 500 SVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITW--NKEGVQITESGKF 557
                V      +  Q+P + +V  G+   ++C         +TW  N   V++ E  + 
Sbjct: 511 QTFFDVSEPPPVI--QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARI 568

Query: 558 HVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
                 +L +    F D G Y C+  +  G +  ++FLTV
Sbjct: 569 RTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTV 608


>gi|134244585 putative neuronal cell adhesion molecule [Homo
           sapiens]
          Length = 814

 Score =  158 bits (399), Expect = 4e-38
 Identities = 122/389 (31%), Positives = 177/389 (45%), Gaps = 38/389 (9%)

Query: 239 EPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTR-- 296
           EP D     G  +   CR EG P   I W  N   ++L + T   +  +G+LMIR+ R  
Sbjct: 47  EPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNG--VELPESTHSTLLANGSLMIRHFRLE 104

Query: 297 ----ESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECM 352
                SD+G Y+C+A+N  G   ++ A ++ +++     F + PQ T    G     +C 
Sbjct: 105 PGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMS---DFHVHPQATVGEEGGVARFQCQ 161

Query: 353 ATGHPHPLITWTRDN-GLELDGSRHVATSSG-LYLQNITQRDHGRFTCHANN------SH 404
             G P PLITW ++   ++ D  R+     G L +  +   D G F C A+N      SH
Sbjct: 162 IHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISH 221

Query: 405 G---TVQAAAN------IIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKT 455
           G   TV  + +       I+  P   T+T     VLE       C A GNP P++ W++ 
Sbjct: 222 GARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLE-------CVATGNPRPIVSWSRL 274

Query: 456 GGQ-LPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFT 514
            G+ + VEG   VL +G L I        G Y C A       + + Q  +  +A A F 
Sbjct: 275 DGRPIGVEGIQ-VLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFV 333

Query: 515 QLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHV-DDEGTLTIYDAGFP 573
           Q PQ  S   G     +C AQGEP P +TW K G  +   G   + ++  TLTI   G  
Sbjct: 334 QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393

Query: 574 DQGRYECVARNSFGLAVTNMFLTVTAIQG 602
           D+  Y+CVA NS G +  +  LTV   +G
Sbjct: 394 DEAIYQCVAENSAGSSQASARLTVLWAEG 422



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 74/272 (27%), Positives = 117/272 (43%), Gaps = 19/272 (6%)

Query: 328 AKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRH--VATSSGLYL 385
           A+ +F ++P D   + G    L+C   G P   ITW R NG+EL  S H  +  +  L +
Sbjct: 40  AELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITW-RKNGVELPESTHSTLLANGSLMI 98

Query: 386 QNI------TQRDHGRFTCHANNSHG-TVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEW 438
           ++       +  D G + C A N  G  V   A I       F V P+  V  E     +
Sbjct: 99  RHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARF 158

Query: 439 LCEADGNPPPVIVWTKTGGQLPVEGQ-HTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVK 497
            C+  G P P+I W K    +  + + +T+L  G L+I      D G + C A +   ++
Sbjct: 159 QCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIR 218

Query: 498 -KVSVQLTVKPKALAVFTQL-----PQDTSVEVGKNINISCHAQGEPQPIITWNK-EGVQ 550
                +LTV       + +      P++ ++ V +   + C A G P+PI++W++ +G  
Sbjct: 219 ISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRP 278

Query: 551 ITESGKFHVDDEGTLTIYDAGFPDQGRYECVA 582
           I   G   V   G L I D      G Y C A
Sbjct: 279 IGVEG-IQVLGTGNLIISDVTVQHSGVYVCAA 309



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 55/179 (30%), Positives = 85/179 (47%), Gaps = 8/179 (4%)

Query: 421 FTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDR--- 477
           F V P D V +    +   C  +G PP  I W K G +LP     T+L++G+L I     
Sbjct: 44  FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103

Query: 478 ---AAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHA 534
               +  D+G YEC A +  G+  VS +  ++   ++ F   PQ T  E G      C  
Sbjct: 104 EPGGSPSDEGDYECVAQNRFGL-VVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQI 162

Query: 535 QGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTN 592
            G P+P+ITW K  V I T++ ++ +  +G L I      D G + CVA N   + +++
Sbjct: 163 HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISH 221



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 57/188 (30%), Positives = 82/188 (43%), Gaps = 10/188 (5%)

Query: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIH-NNHSLDLEDDTRLNVFDDGTL 290
           + P I   P+++ +    T    C A GNP+P + W   +   + +E    + V   G L
Sbjct: 236 KEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEG---IQVLGTGNL 292

Query: 291 MIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLE 350
           +I +      GVY C A N  G    ++A  R   + A   FV  PQ      GT+    
Sbjct: 293 IISDVTVQHSGVYVC-AANRPGTRVRRTAQGRL-VVQAPAEFVQHPQSISRPAGTTAMFT 350

Query: 351 CMATGHPHPLITWTRDNGLELDGSRHVA---TSSGLYLQNITQRDHGRFTCHANNSHGTV 407
           C A G P P +TW + NG  L    HV     +S L +  I   D   + C A NS G+ 
Sbjct: 351 CQAQGEPPPHVTWLK-NGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSS 409

Query: 408 QAAANIIV 415
           QA+A + V
Sbjct: 410 QASARLTV 417



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 40/114 (35%), Positives = 56/114 (49%), Gaps = 5/114 (4%)

Query: 240 PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299
           PQ +  P+G T  FTC+A+G P P + W+ N   L      RL   ++ TL I      D
Sbjct: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK-NNNSTLTISGIGPED 394

Query: 300 QGVYQCMARNSAG--EAKTQSAMLRYSSLPAKPSFV--IQPQDTEVLIGTSTTL 349
           + +YQC+A NSAG  +A  +  +L    LP  P  V  +    TEV +  S  L
Sbjct: 395 EAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPL 448


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score =  153 bits (387), Expect = 1e-36
 Identities = 102/357 (28%), Positives = 163/357 (45%), Gaps = 23/357 (6%)

Query: 252  YFTCRAEGNPKPEIIWIHNNHSLDLED--DTRLNVFDDGTLMIRNTRESDQGVYQCMARN 309
            +F CRAEG P PE++WI  ++         +R+ V  +GTL IRN R SD   + C+ARN
Sbjct: 2258 HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARN 2317

Query: 310  SAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVL--IGTSTTLECMATGHPHPLITWTRDN 367
              GE+      L    +  +P+F   P + +++  +G ST L C   G+P P I W   N
Sbjct: 2318 EGGES-VLVVQLEVLEMLRRPTFR-NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPN 2375

Query: 368  GLELDGSRH-----VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANI-IVQAPPQF 421
            G             +A++    +   T+ D G++ C A N  G ++    + I Q P   
Sbjct: 2376 GTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVIL 2435

Query: 422  TVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL----PVEGQHTVLSSGTLRIDR 477
            T  P     +   ++   C +DG P P I WT   G +     + G++ +  +GTL I  
Sbjct: 2436 TYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKE 2495

Query: 478  AAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGE 537
            A  +D+G Y C+A +S+G   ++V + +      +  + P+      G    + C A G 
Sbjct: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGV 2555

Query: 538  PQPIITWNKEGVQITES-------GKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
            P+P ITW      +  +       G   +  +GTL I +    D G Y+C A+N  G
Sbjct: 2556 PKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612



 Score =  150 bits (378), Expect = 1e-35
 Identities = 109/368 (29%), Positives = 165/368 (44%), Gaps = 29/368 (7%)

Query: 245  VPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL---EDDTRLNVFDDGTLMIRNTRESDQG 301
            +P+ +  +  C A GNP P I W      LDL   + ++R+ V  +GTL I+     D+G
Sbjct: 1660 IPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRG 1719

Query: 302  VYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLI--GTSTTLECMATGHPHP 359
             Y C A N  G       +    S+ + P  +++ +  E+ +  G++  L+C A G P P
Sbjct: 1720 QYLCSASNLFGTDHLHVTL----SVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSP 1775

Query: 360  LITWTRDNGLEL----DGSRH--VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANI 413
             +TW   N   +     GSR   V     L L N++  D G + C A+N  G       I
Sbjct: 1776 TVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKI 1835

Query: 414  IVQAPPQFTVTPKDQVVLEE--HAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHT----- 466
             V A P   +  + QV++     +++  C A G P P + W  + G      Q T     
Sbjct: 1836 QVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLF 1895

Query: 467  VLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALA--VFTQLPQDTSVEV 524
            + S+GTL I   A  D+G YEC A SS G ++  V LT++ +  +  +     + T V  
Sbjct: 1896 LFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNF 1955

Query: 525  GKNINISCHAQGEPQPIITWNKEGVQITE-----SGKFHVDDEGTLTIYDAGFPDQGRYE 579
            G  + ++C A GEP+P I W      + +         HV   G+L I      D G Y 
Sbjct: 1956 GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYL 2015

Query: 580  CVARNSFG 587
            CVARN  G
Sbjct: 2016 CVARNKMG 2023



 Score =  146 bits (368), Expect = 2e-34
 Identities = 112/390 (28%), Positives = 181/390 (46%), Gaps = 39/390 (10%)

Query: 241  QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLED---DTRLNVFDDGTLMIRNTRE 297
            +++ V SG+TV   CRAEG P P + WI  N ++  E      +  V  DGTL++ N   
Sbjct: 1753 KEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSI 1812

Query: 298  SDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT---STTLECMAT 354
             D+G Y+C+A N  G+    S +++   + A P  VI  Q  +V++GT   S  L C A 
Sbjct: 1813 YDRGFYKCVASNPGGQ---DSLLVKIQVIAAPP--VILEQRRQVIVGTWGESLKLPCTAK 1867

Query: 355  GHPHPLITWTRDNG-----LELDGSRHVATSSG-LYLQNITQRDHGRFTCHANNSHGTVQ 408
            G P P + W   +G     L+   S+    S+G LY++N+   D G + C A +S G+ +
Sbjct: 1868 GTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSER 1927

Query: 409  AAANII----VQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQ 464
                +     V +P     + K   V     +   C A G P P I+W +   +  V+ Q
Sbjct: 1928 RVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMW-RLPSKAVVDQQ 1986

Query: 465  HTVLS------SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQ 518
            H V S      +G+L I    + D G Y C A + +G   + + ++++ K   +  +   
Sbjct: 1987 HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF 2046

Query: 519  DTSVEVGKNINISCHAQGEPQPIITWN-------KEGVQITESG----KFHVDDEGTLTI 567
               V  GK+  + C A G P P I+W+          +Q  +SG    ++ + + GTL  
Sbjct: 2047 RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF 2106

Query: 568  YDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
               G  ++G Y C A+N+ G     + LTV
Sbjct: 2107 NKVGVAEEGDYTCYAQNTLGKDEMKVHLTV 2136



 Score =  140 bits (353), Expect = 9e-33
 Identities = 101/368 (27%), Positives = 170/368 (46%), Gaps = 32/368 (8%)

Query: 248  GNTVYFTCRAEGNPKPEIIWIHNNHS--LDLE-DDTRLNVFDDGTLMIRNTRESDQGVYQ 304
            G ++   C A+G P+P + W+ ++ +    L+  +++L +F +GTL IRN   SD+G Y+
Sbjct: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYE 1916

Query: 305  CMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQD-TEVLIGTSTTLECMATGHPHPLITW 363
            C+A +S G  + +  ML        P      Q  TEV  G    L C ATG P P I W
Sbjct: 1917 CIATSSTGSER-RVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMW 1975

Query: 364  TRDNGLELDGSR------HVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
               +   +D         HV  +  L++ ++T++D G + C A N  G      ++ ++ 
Sbjct: 1976 RLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRL 2035

Query: 418  PPQFTVTPKD---QVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEG----------- 463
             P   +  K    + VL     +  C+A G+P P I W+   G +               
Sbjct: 2036 KPA-KIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTR 2094

Query: 464  QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVE 523
            ++T+ ++GTL  ++    ++G Y C A ++LG  ++ V LTV   A  +      +  ++
Sbjct: 2095 RYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIK 2154

Query: 524  VGKNINISCHAQGEPQPIITW---NKEGVQIT-ESGKFHVDDEGTLTIYDAGFPDQGRYE 579
             G    + C   G+P+P I W   + + +  + +   FH +  G+LTI      D G Y 
Sbjct: 2155 AGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHAN--GSLTINKVKLLDSGEYV 2212

Query: 580  CVARNSFG 587
            CVARN  G
Sbjct: 2213 CVARNPSG 2220



 Score =  135 bits (339), Expect = 4e-31
 Identities = 154/658 (23%), Positives = 241/658 (36%), Gaps = 120/658 (18%)

Query: 21  GLPCPSRCLCFKST-VRCMHLMLDHIPQ-VPQQTTVLDLRFNRIREIPGSAFKKLKNLNT 78
           G  CP RC C+  T V C    L  IP  +P     ++L +N +  +  + F  L  L  
Sbjct: 26  GKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLEL 85

Query: 79  LLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQ 138
           L+L++N I  I    F  L+ L  L +  N++  L K TF GL SL  L++  N +E + 
Sbjct: 86  LMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFIN 145

Query: 139 PETFGDL--LRL------------------------------ERLFLHNNKLSKIPAGSF 166
           PE F  L  LRL                              + L+L +N L+ +P    
Sbjct: 146 PEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMV 205

Query: 167 SNLDSLKRLRLDSNALVCDCDLMWLGELLQ---------GFAQHGHTQAAATCEYPRRLH 217
           S +  L  L L  N   CDC L WL + +Q                 Q    C  PR   
Sbjct: 206 SYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSK 265

Query: 218 GRAVASVTVEEFNCQSPRIT------------------FEPQDVEVPSGNTVYFTCRAEG 259
           G+ +A V+   F C  P I                     PQ    P G+         G
Sbjct: 266 GKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSG 325

Query: 260 NPKPEIIWIHNNH-----SLDLEDDTRLNVFDDGTLMIRNTRESD-QGVYQCMARNSAGE 313
           N    +  I         +   E+D  +      T ++ N      Q V+Q +A  S   
Sbjct: 326 NEANMVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSP 385

Query: 314 ---------AKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWT 364
                    ++T     +Y  +  KP  +             T +E      P    +W 
Sbjct: 386 LILERSHLLSETPQLYYKYKQVAPKPEDIF------------TNIEADLRADP----SWL 429

Query: 365 RDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVT 424
             + + L  +R   T S L +Q            +++++  T+  A    V+   ++T+ 
Sbjct: 430 MQDQISLQLNRTATTFSTLQIQ------------YSSDAQITLPRAEMRPVK--HKWTMI 475

Query: 425 PKDQVVLEEH------AVEWLCEADGNPPPVIVWTKTGGQ------LPVEGQHTVLSSGT 472
            +D     EH       V   C   G+P P + W    G       +  +G+  +  SG 
Sbjct: 476 SRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGK 535

Query: 473 LRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISC 532
           L +  A   D G Y C + +      ++ ++TV    +  + +     +V +G+ +++ C
Sbjct: 536 LELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPC 595

Query: 533 HAQGEPQPIITWNKEG--VQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGL 588
           H+ G P   I+W   G  V    S    V + GTL I      DQG Y CVA N  G+
Sbjct: 596 HSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGV 653



 Score =  134 bits (337), Expect = 6e-31
 Identities = 99/384 (25%), Positives = 167/384 (43%), Gaps = 32/384 (8%)

Query: 245  VPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQ 304
            + +G+T    C   G+PKP+I W+  ++ +      R     +G+L I   +  D G Y 
Sbjct: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYV 2212

Query: 305  CMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTT------LECMATGHPH 358
            C+ARN +G+       +    + +KP  +        +I  +         +C A G P 
Sbjct: 2213 CVARNPSGD----DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPS 2268

Query: 359  PLITWTRDNGLELD----GSRHVATSSG-LYLQNITQRDHGRFTCHANNSHGTVQAAANI 413
            P + W   + + L     GSR     +G L ++N+   D   F C A N  G       +
Sbjct: 2269 PEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQL 2328

Query: 414  IV---QAPPQFTVTPKDQVVLE-EHAVEWLCEADGNPPPVIVWTKTGGQL----PVEGQH 465
             V      P F     +++V +   +    C  DGNPPP I+W    G      P   Q+
Sbjct: 2329 EVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQY 2388

Query: 466  TVLSSGTLRIDRAAQHDQGQYECQAVSSLGV--KKVSVQLTVKPKALAVFTQLPQDTSVE 523
             + S+G+  I +  + D G+Y C A + +G   K V +++  KP    + T  P      
Sbjct: 2389 LIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKP---VILTYAPGTVKGI 2445

Query: 524  VGKNINISCHAQGEPQPIITWNKEGVQITE----SGKFHVDDEGTLTIYDAGFPDQGRYE 579
             G+++++ C + G P+P I W      + +    +GK+ + D GTL I +A   D+G Y 
Sbjct: 2446 SGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYI 2505

Query: 580  CVARNSFGLAVTNMFLTVTAIQGR 603
            C A+NS G  +  + + + A   R
Sbjct: 2506 CKAQNSVGHTLITVPVMIVAYPPR 2529



 Score =  105 bits (261), Expect = 4e-22
 Identities = 101/365 (27%), Positives = 158/365 (43%), Gaps = 38/365 (10%)

Query: 257  AEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKT 316
            AE   KPE+  +       L + T L    DG    +NT++SD        +    EA T
Sbjct: 1584 AEKGKKPEVSMLATT---GLSEATTLVSDWDGQ---KNTKKSD------FDKKPVQEATT 1631

Query: 317  QSAMLRYSSLPA----KPSFVIQPQDTEVLIGTSTT-LECMATGHPHPLITWTR-DNGLE 370
             S +L + SL      KP  V     +  +   S   L C A G+P P I WTR  +GL+
Sbjct: 1632 -SKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLD 1690

Query: 371  LDGSRH-----VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANI-IVQAPPQFTVT 424
            L   +      V  +  L +Q +  +D G++ C A+N  GT      + +V  PP+    
Sbjct: 1691 LSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILER 1750

Query: 425  PKDQVVLEEHA-VEWLCEADGNPPPVIVWTKTGGQLPVEG-----QHTVLSSGTLRIDRA 478
               ++ +   + VE  C A+G P P + W      +  E      Q  V   GTL +   
Sbjct: 1751 RTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNL 1810

Query: 479  AQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEP 538
            + +D+G Y+C A +  G   + V++ V      +  Q  Q      G+++ + C A+G P
Sbjct: 1811 SIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTP 1870

Query: 539  QPIITW------NKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTN 592
            QP + W        + +Q T S K  +   GTL I +    D+G YEC+A +S G     
Sbjct: 1871 QPSVYWVLSDGTEVKPLQFTNS-KLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRV 1929

Query: 593  MFLTV 597
            + LT+
Sbjct: 1930 VMLTM 1934



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 56/192 (29%), Positives = 88/192 (45%), Gaps = 16/192 (8%)

Query: 236  ITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIW-IHNNHSLDL-EDDTRLNVFDDGTLMIR 293
            +T+ P  V+  SG ++   C ++G PKP I W + + + +D  + + +  + D+GTL+I+
Sbjct: 2435 LTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIK 2494

Query: 294  NTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQ--PQDTEVLIGTSTTLEC 351
                 D+G Y C A+NS G       ++    + A P  +    P+      G +  L C
Sbjct: 2495 EATAYDRGNYICKAQNSVGHTLITVPVM----IVAYPPRITNRPPRSIVTRTGAAFQLHC 2550

Query: 352  MATGHPHPLITWTR-DNGL-------ELDGSRHVATSSGLYLQNITQRDHGRFTCHANNS 403
            +A G P P ITW   D+ L          GS  +     L +QN    D G + C A N 
Sbjct: 2551 VALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNP 2610

Query: 404  HGTVQAAANIIV 415
             G+  AA  I V
Sbjct: 2611 LGSDYAATYIQV 2622



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 67/265 (25%), Positives = 103/265 (38%), Gaps = 25/265 (9%)

Query: 261 PKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAM 320
           PKPE I+   N   DL  D    + D  +L +  T  +    +  +    + +A  Q  +
Sbjct: 409 PKPEDIF--TNIEADLRADPSWLMQDQISLQLNRTATT----FSTLQIQYSSDA--QITL 460

Query: 321 LRYSSLPAKPSFVIQPQDTE------VLIGTSTTLECMATGHPHPLITWTRDNGLEL--- 371
            R    P K  + +  +D        VL+G +  L C   G P P + W   +G ++   
Sbjct: 461 PRAEMRPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAP 520

Query: 372 ----DGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAP--PQFTVTP 425
               DG   +  S  L LQ     D G + C ++N          I V  P    +    
Sbjct: 521 YVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENG 580

Query: 426 KDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHT--VLSSGTLRIDRAAQHDQ 483
               V     ++  C + G P   I W   G  +  +      VL++GTLRI +    DQ
Sbjct: 581 IHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQ 640

Query: 484 GQYECQAVSSLGVKKVSVQLTVKPK 508
           G Y C A +  GV  +  Q++VK K
Sbjct: 641 GYYRCVAANPSGVDFLIFQVSVKMK 665



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 10/87 (11%)

Query: 234  PRITFEP-QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSL-------DLEDDTRLNVF 285
            PRIT  P + +   +G      C A G PKPEI W   +HSL             +L++ 
Sbjct: 2528 PRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL- 2586

Query: 286  DDGTLMIRNTRESDQGVYQCMARNSAG 312
              GTL+I+N + SD G+Y+C A+N  G
Sbjct: 2587 -QGTLVIQNPQTSDSGIYKCTAKNPLG 2612



 Score = 40.0 bits (92), Expect = 0.016
 Identities = 24/79 (30%), Positives = 39/79 (49%), Gaps = 5/79 (6%)

Query: 530  ISCHAQGEPQPIITWNK--EGVQIT---ESGKFHVDDEGTLTIYDAGFPDQGRYECVARN 584
            + C A G P P I W +   G+ ++   ++ +  V   GTL+I      D+G+Y C A N
Sbjct: 1668 LPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASN 1727

Query: 585  SFGLAVTNMFLTVTAIQGR 603
             FG    ++ L+V +   R
Sbjct: 1728 LFGTDHLHVTLSVVSYPPR 1746


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,351,937
Number of Sequences: 37866
Number of extensions: 2984325
Number of successful extensions: 18518
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 452
Number of HSP's successfully gapped in prelim test: 240
Number of HSP's that attempted gapping in prelim test: 8107
Number of HSP's gapped (non-prelim): 4272
length of query: 1463
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1348
effective length of database: 13,892,928
effective search space: 18727666944
effective search space used: 18727666944
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.