Search of human proteins with 126131099

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|126131099 guanine nucleotide exchange factor p532 [Homo
sapiens]
         (4861 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]  9748   0.0  
gi|126032348 hect domain and RLD 2 [Homo sapiens]                     682   0.0  
gi|157738609 HECT domain containing 3 [Homo sapiens]                  196   4e-49
gi|7657152 hect domain and RLD 3 [Homo sapiens]                       181   1e-44
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]            170   4e-41
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]            170   4e-41
gi|4557445 regulator of chromosome condensation and BTB domain c...   153   5e-36
gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens]       151   2e-35
gi|61563742 hect domain and RLD 6 [Homo sapiens]                      150   4e-35
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo...   149   9e-35
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...   149   9e-35
gi|114520609 neural precursor cell expressed, developmentally do...   145   1e-33
gi|114520607 neural precursor cell expressed, developmentally do...   145   1e-33
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...   144   3e-33
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ...   140   4e-32
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...   139   5e-32
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]      139   5e-32
gi|110825982 hect domain and RLD 5 [Homo sapiens]                     139   7e-32
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...   137   3e-31
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...   137   3e-31
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ...   137   3e-31
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...   137   3e-31
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s...   135   8e-31
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i...   132   8e-30
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i...   132   8e-30
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s...   132   1e-29
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                     132   1e-29
gi|222352183 neural precursor cell expressed, developmentally do...   131   1e-29
gi|21361472 neural precursor cell expressed, developmentally dow...   131   1e-29
gi|222352094 neural precursor cell expressed, developmentally do...   131   1e-29

>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score = 9748 bits (25295), Expect = 0.0
 Identities = 4861/4861 (100%), Positives = 4861/4861 (100%)

Query: 1    MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGP 60
            MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGP
Sbjct: 1    MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGP 60

Query: 61   QLPDFERESLSSDEQDHYLDALLSSQLALAKMVCSDSPFAGALRKRLLVLQRVFYALSNK 120
            QLPDFERESLSSDEQDHYLDALLSSQLALAKMVCSDSPFAGALRKRLLVLQRVFYALSNK
Sbjct: 61   QLPDFERESLSSDEQDHYLDALLSSQLALAKMVCSDSPFAGALRKRLLVLQRVFYALSNK 120

Query: 121  YHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP 180
            YHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
Sbjct: 121  YHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP 180

Query: 181  VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGAD 240
            VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGAD
Sbjct: 181  VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGAD 240

Query: 241  TLGRRLASELLLGLAAQRGSLRYLLEWIEMALGASAVVHTMEKGKLLSSQEGMISFDCFM 300
            TLGRRLASELLLGLAAQRGSLRYLLEWIEMALGASAVVHTMEKGKLLSSQEGMISFDCFM
Sbjct: 241  TLGRRLASELLLGLAAQRGSLRYLLEWIEMALGASAVVHTMEKGKLLSSQEGMISFDCFM 300

Query: 301  TILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI 360
            TILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
Sbjct: 301  TILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI 360

Query: 361  QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVIST 420
            QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVIST
Sbjct: 361  QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVIST 420

Query: 421  DGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVF 480
            DGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVF
Sbjct: 421  DGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVF 480

Query: 481  SWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF 540
            SWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
Sbjct: 481  SWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF 540

Query: 541  GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTN 600
            GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTN
Sbjct: 541  GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTN 600

Query: 601  RVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIE 660
            RVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIE
Sbjct: 601  RVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIE 660

Query: 661  ELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI 720
            ELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI
Sbjct: 661  ELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI 720

Query: 721  QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLP 780
            QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLP
Sbjct: 721  QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLP 780

Query: 781  FPSSREHHSFLKLCLKLLSNHLALALAGGVATSILGRQAGPLRNLLFRLMDSTVPDEIQE 840
            FPSSREHHSFLKLCLKLLSNHLALALAGGVATSILGRQAGPLRNLLFRLMDSTVPDEIQE
Sbjct: 781  FPSSREHHSFLKLCLKLLSNHLALALAGGVATSILGRQAGPLRNLLFRLMDSTVPDEIQE 840

Query: 841  VVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA 900
            VVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA
Sbjct: 841  VVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA 900

Query: 901  SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAF 960
            SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAF
Sbjct: 901  SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAF 960

Query: 961  GELEKNSDKFLLGTSSSENSQPAHLHELLCSLQKQLLAFCHINNISENSSSVALLHKHLQ 1020
            GELEKNSDKFLLGTSSSENSQPAHLHELLCSLQKQLLAFCHINNISENSSSVALLHKHLQ
Sbjct: 961  GELEKNSDKFLLGTSSSENSQPAHLHELLCSLQKQLLAFCHINNISENSSSVALLHKHLQ 1020

Query: 1021 LLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP 1080
            LLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP
Sbjct: 1021 LLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP 1080

Query: 1081 LLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVD 1140
            LLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVD
Sbjct: 1081 LLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVD 1140

Query: 1141 LERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVEMDTPQLDKCMSCLLEVA 1200
            LERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVEMDTPQLDKCMSCLLEVA
Sbjct: 1141 LERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVEMDTPQLDKCMSCLLEVA 1200

Query: 1201 LSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLL 1260
            LSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLL
Sbjct: 1201 LSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLL 1260

Query: 1261 DTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRS 1320
            DTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRS
Sbjct: 1261 DTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRS 1320

Query: 1321 SSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEGHPEPEDEEEEREHEVM 1380
            SSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEGHPEPEDEEEEREHEVM
Sbjct: 1321 SSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEGHPEPEDEEEEREHEVM 1380

Query: 1381 TAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA 1440
            TAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA
Sbjct: 1381 TAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA 1440

Query: 1441 ACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVH 1500
            ACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVH
Sbjct: 1441 ACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVH 1500

Query: 1501 TSPNYRLIKSRSESDLSQPESDEEGYALSGRRNVDLDLAASHRKRGPMHSQLESLSDSWA 1560
            TSPNYRLIKSRSESDLSQPESDEEGYALSGRRNVDLDLAASHRKRGPMHSQLESLSDSWA
Sbjct: 1501 TSPNYRLIKSRSESDLSQPESDEEGYALSGRRNVDLDLAASHRKRGPMHSQLESLSDSWA 1560

Query: 1561 RLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSP 1620
            RLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSP
Sbjct: 1561 RLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSP 1620

Query: 1621 QASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQ 1680
            QASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQ
Sbjct: 1621 QASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQ 1680

Query: 1681 FLAGCFGLGTVGHTGGKGESGRLHHYQDGIRAAKRNIQIEIQVAVHKIYQQLSATLERAL 1740
            FLAGCFGLGTVGHTGGKGESGRLHHYQDGIRAAKRNIQIEIQVAVHKIYQQLSATLERAL
Sbjct: 1681 FLAGCFGLGTVGHTGGKGESGRLHHYQDGIRAAKRNIQIEIQVAVHKIYQQLSATLERAL 1740

Query: 1741 QANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLSQLCGTDTMLGQPLQLLP 1800
            QANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLSQLCGTDTMLGQPLQLLP
Sbjct: 1741 QANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLSQLCGTDTMLGQPLQLLP 1800

Query: 1801 KTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLLDLLCSQLKNLLSQTGVLH 1860
            KTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLLDLLCSQLKNLLSQTGVLH
Sbjct: 1801 KTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLLDLLCSQLKNLLSQTGVLH 1860

Query: 1861 MASFGEGEQEDGEEEEKKVDSSGETEKKDFRAALRKQHAAELHLGDFLVFLRRVVSSKAI 1920
            MASFGEGEQEDGEEEEKKVDSSGETEKKDFRAALRKQHAAELHLGDFLVFLRRVVSSKAI
Sbjct: 1861 MASFGEGEQEDGEEEEKKVDSSGETEKKDFRAALRKQHAAELHLGDFLVFLRRVVSSKAI 1920

Query: 1921 QSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMAQI 1980
            QSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMAQI
Sbjct: 1921 QSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMAQI 1980

Query: 1981 VERLFSLLSDCMWETPIAQAKHAIQIKEKEQEIKLQKQGELEEEDENLPIQEVSFDPEKA 2040
            VERLFSLLSDCMWETPIAQAKHAIQIKEKEQEIKLQKQGELEEEDENLPIQEVSFDPEKA
Sbjct: 1981 VERLFSLLSDCMWETPIAQAKHAIQIKEKEQEIKLQKQGELEEEDENLPIQEVSFDPEKA 2040

Query: 2041 QCCLVENGQILTHGSGGKGYGLASTGVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDF 2100
            QCCLVENGQILTHGSGGKGYGLASTGVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDF
Sbjct: 2041 QCCLVENGQILTHGSGGKGYGLASTGVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDF 2100

Query: 2101 NHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFTQGDFITCVLDMEARTISFGKNGEEPKLA 2160
            NHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFTQGDFITCVLDMEARTISFGKNGEEPKLA
Sbjct: 2101 NHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFTQGDFITCVLDMEARTISFGKNGEEPKLA 2160

Query: 2161 FEDVDAAELYPCVMFYSSNPGEKVKICDMQMRGTPRDLLPGDPICSPVAAVLAEATIQLI 2220
            FEDVDAAELYPCVMFYSSNPGEKVKICDMQMRGTPRDLLPGDPICSPVAAVLAEATIQLI
Sbjct: 2161 FEDVDAAELYPCVMFYSSNPGEKVKICDMQMRGTPRDLLPGDPICSPVAAVLAEATIQLI 2220

Query: 2221 RILHRTDRWTYCINKKMMERLHKIKICIKESGQKLKKSRSVQSREENEMREEKESKEEEK 2280
            RILHRTDRWTYCINKKMMERLHKIKICIKESGQKLKKSRSVQSREENEMREEKESKEEEK
Sbjct: 2221 RILHRTDRWTYCINKKMMERLHKIKICIKESGQKLKKSRSVQSREENEMREEKESKEEEK 2280

Query: 2281 GKHTRHGLADLSELQLRTLCIEVWPVLAVIGGVDAGLRVGGRCVHKQTGRHATLLGVVKE 2340
            GKHTRHGLADLSELQLRTLCIEVWPVLAVIGGVDAGLRVGGRCVHKQTGRHATLLGVVKE
Sbjct: 2281 GKHTRHGLADLSELQLRTLCIEVWPVLAVIGGVDAGLRVGGRCVHKQTGRHATLLGVVKE 2340

Query: 2341 GSTSAKVQWDEAEITISFPTFWSPSDTPLYNLEPCEPLPFDVARFRGLTASVLLDLTYLT 2400
            GSTSAKVQWDEAEITISFPTFWSPSDTPLYNLEPCEPLPFDVARFRGLTASVLLDLTYLT
Sbjct: 2341 GSTSAKVQWDEAEITISFPTFWSPSDTPLYNLEPCEPLPFDVARFRGLTASVLLDLTYLT 2400

Query: 2401 GVHEDMGKQSTKRHEKKHRHESEEKGDVEQKPESESALDMRTGLTSDDVKSQSTTSSKSE 2460
            GVHEDMGKQSTKRHEKKHRHESEEKGDVEQKPESESALDMRTGLTSDDVKSQSTTSSKSE
Sbjct: 2401 GVHEDMGKQSTKRHEKKHRHESEEKGDVEQKPESESALDMRTGLTSDDVKSQSTTSSKSE 2460

Query: 2461 NEIASFSLDPTLPSVESQHQITEGKRKNHEHMSKNHDVAQSEIRAVQLSYLYLGAMKSLS 2520
            NEIASFSLDPTLPSVESQHQITEGKRKNHEHMSKNHDVAQSEIRAVQLSYLYLGAMKSLS
Sbjct: 2461 NEIASFSLDPTLPSVESQHQITEGKRKNHEHMSKNHDVAQSEIRAVQLSYLYLGAMKSLS 2520

Query: 2521 ALLGCSKYAELLLIPKVLAENGHNSDCASSPVVHEDVEMRAALQFLMRHMVKRAVMRSPI 2580
            ALLGCSKYAELLLIPKVLAENGHNSDCASSPVVHEDVEMRAALQFLMRHMVKRAVMRSPI
Sbjct: 2521 ALLGCSKYAELLLIPKVLAENGHNSDCASSPVVHEDVEMRAALQFLMRHMVKRAVMRSPI 2580

Query: 2581 KRALGLADLERAQAMIYKLVVHGLLEDQFGGKIKQEIDQQAEESDPAQQAQTPVTTSPSA 2640
            KRALGLADLERAQAMIYKLVVHGLLEDQFGGKIKQEIDQQAEESDPAQQAQTPVTTSPSA
Sbjct: 2581 KRALGLADLERAQAMIYKLVVHGLLEDQFGGKIKQEIDQQAEESDPAQQAQTPVTTSPSA 2640

Query: 2641 SSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTTVLPTRRAQ 2700
            SSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTTVLPTRRAQ
Sbjct: 2641 SSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTTVLPTRRAQ 2700

Query: 2701 TPPISSLPTSPSDEVGRRQSLTSPDSQSARPANRTALSDPSSRLSTSPPPPAIAVPLLEM 2760
            TPPISSLPTSPSDEVGRRQSLTSPDSQSARPANRTALSDPSSRLSTSPPPPAIAVPLLEM
Sbjct: 2701 TPPISSLPTSPSDEVGRRQSLTSPDSQSARPANRTALSDPSSRLSTSPPPPAIAVPLLEM 2760

Query: 2761 GFSLRQIAKAMEATGARGEADAQNITVLAMWMIEHPGHEDEEEPQSGSTADSRPGAAVLG 2820
            GFSLRQIAKAMEATGARGEADAQNITVLAMWMIEHPGHEDEEEPQSGSTADSRPGAAVLG
Sbjct: 2761 GFSLRQIAKAMEATGARGEADAQNITVLAMWMIEHPGHEDEEEPQSGSTADSRPGAAVLG 2820

Query: 2821 SGGKSNDPCYLQSPGDIPSADAAEMEEGFSESPDNLDHTENAASGSGPSARGRSAVTRRH 2880
            SGGKSNDPCYLQSPGDIPSADAAEMEEGFSESPDNLDHTENAASGSGPSARGRSAVTRRH
Sbjct: 2821 SGGKSNDPCYLQSPGDIPSADAAEMEEGFSESPDNLDHTENAASGSGPSARGRSAVTRRH 2880

Query: 2881 KFDLAARTLLARAAGLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAME 2940
            KFDLAARTLLARAAGLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAME
Sbjct: 2881 KFDLAARTLLARAAGLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAME 2940

Query: 2941 AMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHP 3000
            AMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHP
Sbjct: 2941 AMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHP 3000

Query: 3001 GCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKG 3060
            GCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKG
Sbjct: 3001 GCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKG 3060

Query: 3061 QAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDP 3120
            QAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDP
Sbjct: 3061 QAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDP 3120

Query: 3121 LGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAA 3180
            LGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAA
Sbjct: 3121 LGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAA 3180

Query: 3181 AQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPS 3240
            AQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPS
Sbjct: 3181 AQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPS 3240

Query: 3241 AMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVN 3300
            AMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVN
Sbjct: 3241 AMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVN 3300

Query: 3301 LTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEK 3360
            LTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEK
Sbjct: 3301 LTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEK 3360

Query: 3361 KGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCS 3420
            KGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCS
Sbjct: 3361 KGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCS 3420

Query: 3421 FIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEES 3480
            FIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEES
Sbjct: 3421 FIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEES 3480

Query: 3481 LGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPAT 3540
            LGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPAT
Sbjct: 3481 LGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPAT 3540

Query: 3541 AWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVG 3600
            AWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVG
Sbjct: 3541 AWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVG 3600

Query: 3601 YFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDPTGHILMTCAKEDSVKLWGSISGCW 3660
            YFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDPTGHILMTCAKEDSVKLWGSISGCW
Sbjct: 3601 YFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDPTGHILMTCAKEDSVKLWGSISGCW 3660

Query: 3661 CCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGW 3720
            CCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGW
Sbjct: 3661 CCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGW 3720

Query: 3721 WEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGS 3780
            WEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGS
Sbjct: 3721 WEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGS 3780

Query: 3781 VLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVLVVNCTAEWAAANHVLATCRTALKQQG 3840
            VLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVLVVNCTAEWAAANHVLATCRTALKQQG
Sbjct: 3781 VLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVLVVNCTAEWAAANHVLATCRTALKQQG 3840

Query: 3841 VLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLL 3900
            VLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLL
Sbjct: 3841 VLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLL 3900

Query: 3901 CNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPE 3960
            CNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPE
Sbjct: 3901 CNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPE 3960

Query: 3961 DELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVP 4020
            DELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVP
Sbjct: 3961 DELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVP 4020

Query: 4021 AAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFV 4080
            AAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFV
Sbjct: 4021 AAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFV 4080

Query: 4081 VTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMS 4140
            VTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMS
Sbjct: 4081 VTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMS 4140

Query: 4141 CGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLA 4200
            CGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLA
Sbjct: 4141 CGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLA 4200

Query: 4201 VSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHV 4260
            VSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHV
Sbjct: 4201 VSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHV 4260

Query: 4261 YTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSE 4320
            YTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSE
Sbjct: 4261 YTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSE 4320

Query: 4321 GQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPD 4380
            GQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPD
Sbjct: 4321 GQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPD 4380

Query: 4381 TVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQ 4440
            TVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQ
Sbjct: 4381 TVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQ 4440

Query: 4441 GQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKL 4500
            GQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKL
Sbjct: 4441 GQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKL 4500

Query: 4501 NASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYN 4560
            NASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYN
Sbjct: 4501 NASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYN 4560

Query: 4561 RDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEE 4620
            RDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEE
Sbjct: 4561 RDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEE 4620

Query: 4621 VDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNR 4680
            VDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNR
Sbjct: 4621 VDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNR 4680

Query: 4681 KEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKK 4740
            KEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKK
Sbjct: 4681 KEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKK 4740

Query: 4741 VVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDR 4800
            VVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDR
Sbjct: 4741 VVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDR 4800

Query: 4801 PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTD 4860
            PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTD
Sbjct: 4801 PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTD 4860

Query: 4861 Y 4861
            Y
Sbjct: 4861 Y 4861


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score =  682 bits (1760), Expect = 0.0
 Identities = 404/1025 (39%), Positives = 570/1025 (55%), Gaps = 70/1025 (6%)

Query: 3850 MRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHH 3909
            + A ++ LP  LQ Q+ YE P V  G QL+HSP+ + L +LA  L LD L C        
Sbjct: 3813 LAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLELDTLPC-------- 3864

Query: 3910 QNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFT------VPDLEPVPEDEL 3963
              C         ++WAW   +    + A AL      P  F       + +L    E+  
Sbjct: 3865 --CA------ETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSENMD 3916

Query: 3964 VFLMDNSKWINGMDEQIMSWATSRPEDWHL--GGKCDVYLWGAGRHGQLAEA-GRNVMVP 4020
            V    +  +    DEQ++ W   RP+DW L  GG   +Y WG    GQL    G  V VP
Sbjct: 3917 VLHESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVP 3976

Query: 4021 AAAPSFSQAQ--QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQG 4078
                + +  +  Q+I G+   F + A+G + A G G+ GRLG G ++ +   T++ ++Q 
Sbjct: 3977 TPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQH 4036

Query: 4079 FVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQ 4138
              + ++  + G   H +AL+  GEV+SWG+ + GKLGHGN     RPR IE+L+G EVV 
Sbjct: 4037 VFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVD 4095

Query: 4139 MSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN-- 4196
            ++ G  HSA VT+ G L+T+G G YGRLG  ++ ++  P+ V AL+G+++  +ACG    
Sbjct: 4096 VAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDA 4155

Query: 4197 HTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTK 4256
             TL ++ D + VW++GDGDYGKLG G S     P KID L G+G+ KV CG+QFSVALTK
Sbjct: 4156 QTLCLTDDDT-VWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 4214

Query: 4257 DGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWG 4316
             G VYT+G+     L  G   +  RP+Q+  L G  +  +A G+ H +    +G+VY WG
Sbjct: 4215 SGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274

Query: 4317 SNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQL 4376
             N EGQLG G TN ++ P LV  LQGK V +++ G  H+ AW+           S P   
Sbjct: 4275 DNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS----------TSKPASA 4324

Query: 4377 G-LPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGT 4435
            G LP  VP +Y  L+E+ I  +R RL LL+H S+L      + +L    + S      G 
Sbjct: 4325 GKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDL----EGSLDETGLGP 4380

Query: 4436 WGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRK---------- 4485
              +    LR +L  +       + +  TMV+ + +GP + + RI  +  +          
Sbjct: 4381 -SVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDG 4439

Query: 4486 CKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVD 4545
             K +F Q+  ++       L LP R WKVK VGE  DD GG + ++I E+C+EL+ G+  
Sbjct: 4440 TKSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTP 4499

Query: 4546 LLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVW 4605
            LLI +PN   E G NRD +L +P+A    H   F+FLG+L+G+AIRT  PL L+LA  VW
Sbjct: 4500 LLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVW 4559

Query: 4606 KQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMV 4664
            KQL  + LT+ DL EVD  ++     +++I D+  T E F  M +P   F   SA G+ +
Sbjct: 4560 KQLAGMSLTIADLSEVDKDFIP---GLMYIRDNEATSEEFEAMSLP---FTVPSASGQDI 4613

Query: 4665 PIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLE 4724
             +        +T  NR EYV  AI YRLHE D QVAAVREGM+ +VPVPLLSL T  +LE
Sbjct: 4614 QL--SSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELE 4671

Query: 4725 QMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPA 4784
             MVCG P+I + +LK V  Y+ ++    L+QWFW  +E FSN ER LF+RFV GR+RLP 
Sbjct: 4672 TMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPR 4731

Query: 4785 NTADISQR-FQIMKVDR---PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSI 4840
              AD   R F I  +D+   P   LP S TCFF L+LP YS + V+ E+L+YAI+ C+SI
Sbjct: 4732 TIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSI 4791

Query: 4841 DMDNY 4845
            D D+Y
Sbjct: 4792 DTDDY 4796



 Score =  277 bits (708), Expect = 2e-73
 Identities = 160/382 (41%), Positives = 227/382 (59%), Gaps = 10/382 (2%)

Query: 3999 VYLWGAGRHGQLAEA-GRNVMVPAAAPSFSQAQ--QVICGQNCTFVIQANGTVLACGEGS 4055
            V++WG     QL    G  + VP+ + + S     QV  G    F +   G V ACGE +
Sbjct: 2961 VFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEAT 3020

Query: 4056 YGRLGQG-NSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKL 4114
             GRLG G +S  + +   I+AL  +VV ++    G   H+ ALT  G+VFSWG+GD GKL
Sbjct: 3021 NGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGKL 3079

Query: 4115 GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK 4174
            GH +     +PR IEAL+ + +  ++CG  HSA +TS G+L+T+G G+YGRLG G+ + +
Sbjct: 3080 GHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQ 3139

Query: 4175 KLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQK 4232
              P+ V  L G+++ QVACG     TLA++ +G +V+++GDGD+GKLG G S   + PQ 
Sbjct: 3140 LKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSWGDGDFGKLGRGGSEGCNIPQN 3198

Query: 4233 IDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVI 4292
            I+ L G G+ ++ CG QFS+ALTK G V+T+G+     L  G   +  +PQ +  L G  
Sbjct: 3199 IERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKK 3258

Query: 4293 IEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGR 4352
            I  VAVGA H LA+  +G VYAWG N  GQ G G T   R+PTLV GL+G+ + +++ G 
Sbjct: 3259 IVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGS 3318

Query: 4353 CHSAAWTAPPVPPRAPGVSVPL 4374
             HS AWT   V    P V  P+
Sbjct: 3319 SHSVAWTT--VDVATPSVHEPV 3338



 Score =  268 bits (686), Expect = 7e-71
 Identities = 233/720 (32%), Positives = 352/720 (48%), Gaps = 84/720 (11%)

Query: 455  RSIKKVSSSKGSDGHT-LAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQ---GPLQG 510
            R+I K+++   SDGH  LA    GEV+SWG GD G+LGHG++   + PK+I    G   G
Sbjct: 493  RNIVKIAAH--SDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAG 550

Query: 511  KVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--VGEVSC 568
            K VV ++ G  +SAA+T +GELYTWG G++GRLGHG S    IP LV  +    V +V+C
Sbjct: 551  KHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVAC 610

Query: 569  GS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSS 626
            GS  + T+A++++G+ VWS+G GD GKLG G ++    PK+IE LQ + + KV  GSQ S
Sbjct: 611  GSGDAQTLAVTENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669

Query: 627  LALTSTGQVYAWGCG--ACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDN 684
            +ALT  GQVY+WG G    LG G+ E     PKL+E L   +++DV+ G +HCLAL+ D+
Sbjct: 670  IALTKDGQVYSWGKGDNQRLGHGTEEHVRY-PKLLEGLQGKKVIDVAAGSTHCLALTEDS 728

Query: 685  EVYAWGNNSMGQCGQGNSTGPITKPKKVS--GLDGIAIQQISAGTSHSLAWTALPRDRQV 742
            EV++WG+N   QC Q   T  +TKP+  +  GLD   I  I+ G + S AW++       
Sbjct: 729  EVHSWGSND--QC-QHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSC--SEWS 783

Query: 743  VAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHL 802
            +    P+ VD+   TF  L   L +  + ++       +P  +E        L LL   L
Sbjct: 784  IGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGS---ADWPPPQEKECVAVATLNLLRLQL 840

Query: 803  ALALAGGVATSILGRQAG-----PLRNLLFRLMDST-VPDEIQEVVIETLSVGATMLLPP 856
              A++  V    LG   G      L+  +  L  S  V   +Q      L  G ++LLP 
Sbjct: 841  HAAISHQVDPEFLGLGLGSILLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPT 900

Query: 857  LRERMELLHSLLPQGPDRWE-SLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADLS 915
              ER   L +LLP      E ++S G+R  +D+++ SL     + S L  +  ++  D+ 
Sbjct: 901  AEERARALSALLPCAVSGNEVNISPGRRFMIDLLVGSLMADGGLESALHAAITAEIQDIE 960

Query: 916  S--VCTGYGNLSDQPYGTQSCHP----------DTHLAEI----------LMKTLLRNLG 953
            +         + +Q     + H           +T + E           L++ LLRN+ 
Sbjct: 961  AKKEAQKEKEIDEQEANASTFHRSRTPLDKDLINTGICESSGKQCLPLVQLIQQLLRNIA 1020

Query: 954  FYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLCSLQKQLLAFCH----INNISENS 1009
              T     ++ +      L        + A L +LL   Q+ L++  +    I   S+ S
Sbjct: 1021 SQTVARLKDVARRISS-CLDFEQHSRERSASL-DLLLRFQRLLISKLYPGESIGQTSDIS 1078

Query: 1010 SSV-----ALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYV---SAAGS 1061
            S       +LL K+  LL  H  DI   +A++   S W         +V Y+      G 
Sbjct: 1079 SPELMGVGSLLKKYTALLCTHIGDILPVAASIASTS-W-----RHFAEVAYIVEGDFTGV 1132

Query: 1062 MLCQIVNSLLLL--------PVSVARPLLSYLLDLLPPLDCLNRLLPAADLLEDQELQWP 1113
            +L ++V S++LL          + A PLL  LL+    LD  N L P  +  + +EL WP
Sbjct: 1133 LLPELVVSIVLLLSKNAGLMQEAGAVPLLGGLLE---HLDRFNHLAPGKERDDHEELAWP 1189



 Score =  264 bits (674), Expect = 2e-69
 Identities = 151/369 (40%), Positives = 222/369 (60%), Gaps = 13/369 (3%)

Query: 374  VYVWGSNSSHQL--VEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGS 431
            +Y WG N   QL  +EG + K+  P  A +      +  G+   F ++ DG + A G G+
Sbjct: 3954 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGA 4013

Query: 432  YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491
             GRLG+G + + ST   L    H  IKKV+ + G   H LA ++EGEV+SWG+ + GKLG
Sbjct: 4014 GGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGK-HCLALSSEGEVYSWGEAEDGKLG 4072

Query: 492  HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSR 551
            HGN S    P++I+  L+G  VV V+AG  HSA VT  G+LYTWG+G +GRLGH DS  +
Sbjct: 4073 HGNRSPCDRPRVIES-LRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQ 4131

Query: 552  NIPTLVKDISN--VGEVSCGS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKV 607
              P LV+ +    V +++CGS  + T+ L+ D  TVWS+G GD GKLG G ++    P  
Sbjct: 4132 LKPKLVEALQGHRVVDIACGSGDAQTLCLTDDD-TVWSWGDGDYGKLGRGGSDGCKVPMK 4190

Query: 608  IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAAT 665
            I++L G+ + KV  GSQ S+ALT +G VY WG G    LG GS +    RP+ ++ L   
Sbjct: 4191 IDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVR-RPRQVQGLQGK 4249

Query: 666  RIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISA 725
            +++ ++ G  HC+  + D EVY WG+N  GQ G G +T  I +P+ V+ L G  + +++ 
Sbjct: 4250 KVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDG-TTNAIQRPRLVAALQGKKVNRVAC 4308

Query: 726  GTSHSLAWT 734
            G++H+LAW+
Sbjct: 4309 GSAHTLAWS 4317



 Score =  254 bits (650), Expect = 1e-66
 Identities = 149/372 (40%), Positives = 221/372 (59%), Gaps = 12/372 (3%)

Query: 373  EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEA--GQYCTFVISTDGSVRACGKG 430
            +V+VWG N   QL      KI  P  + + S    ++   G    F ++ +G V ACG+ 
Sbjct: 2960 KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEA 3019

Query: 431  SYGRLGLGDSNNQSTL-KKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGK 489
            + GRLGLG S+    + +++T      +KKV+   G   H  A T +G+VFSWG+GD GK
Sbjct: 3020 TNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGR-HATALTVDGKVFSWGEGDDGK 3078

Query: 490  LGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSN 549
            LGH +      P+LI+  L+ K +  ++ G  HSAA+T  GELYTWG G++GRLGHGD+ 
Sbjct: 3079 LGHFSRMNCDKPRLIEA-LKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNT 3137

Query: 550  SRNIPTLVKDI--SNVGEVSCGS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKP 605
            ++  P +VK +    V +V+CGS  + T+AL+ +G  V+S+G GD GKLG G +     P
Sbjct: 3138 TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG-LVFSWGDGDFGKLGRGGSEGCNIP 3196

Query: 606  KVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLIEELAA 664
            + IE L G  + ++  G+Q SLALT +G V+ WG G     G  S+    +P+++E L  
Sbjct: 3197 QNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRG 3256

Query: 665  TRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQIS 724
             +IV V++G  HCLA++   +VYAWG+N  GQ G G +T    KP  V GL+G  I +++
Sbjct: 3257 KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTT-VNRKPTLVQGLEGQKITRVA 3315

Query: 725  AGTSHSLAWTAL 736
             G+SHS+AWT +
Sbjct: 3316 CGSSHSVAWTTV 3327



 Score =  215 bits (547), Expect = 1e-54
 Identities = 130/342 (38%), Positives = 195/342 (57%), Gaps = 30/342 (8%)

Query: 4031 QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVT-SCG 4089
            Q+ C +    ++  NG V              NSD L    V    QG     +V  +  
Sbjct: 455  QIACAEKRFLILSRNGRVYTQAY---------NSDTLAPQLV----QGLASRNIVKIAAH 501

Query: 4090 SDGHS-MALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEE----VVQMSCGFK 4144
            SDGH  +AL  +GEV+SWG GD G+LGHG++     P+ I A  G++    VV ++CG  
Sbjct: 502  SDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGST 561

Query: 4145 HSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVS 4202
            +SA +T++G+L+T+G G+YGRLG G++ ++ +P  V  L+G ++  VACG     TLAV+
Sbjct: 562  YSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVT 621

Query: 4203 ADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYT 4262
             +G  VW++GDGDYGKLG G S    +P+ I+ L  + + KV CG+QFS+ALTKDG VY+
Sbjct: 622  ENGQ-VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYS 680

Query: 4263 FGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQ 4322
            +G+     L  G   +   P+ +  L G  + DVA G+ H LAL  + +V++WGSN + Q
Sbjct: 681  WGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740

Query: 4323 LGLGHTNHVR----EPTLVTGLQGKNVRQISAGRCHSAAWTA 4360
                H + +R    EP  + GL  K++  I+ G   S AW++
Sbjct: 741  ----HFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 778



 Score =  164 bits (414), Expect = 3e-39
 Identities = 124/385 (32%), Positives = 179/385 (46%), Gaps = 36/385 (9%)

Query: 368  VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIE--AGQYCTFVISTDGSVR 425
            +S   EVY WG     +L  G +    +P++  S    + ++  AG   +  ++  G + 
Sbjct: 4054 LSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 4113

Query: 426  ACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGS-DGHTLAFTTEGEVFSWGD 484
              GKG YGRLG  DS +Q  LK    E  +  + V  + GS D  TL  T +  V+SWGD
Sbjct: 4114 TWGKGRYGRLGHSDSEDQ--LKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGD 4171

Query: 485  GDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544
            GDYGKLG G S   K P  I   L G  VV V  G + S A+T+ G +YTWG+GD+ RLG
Sbjct: 4172 GDYGKLGRGGSDGCKVPMKIDS-LTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG 4230

Query: 545  HGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRV 602
            HG  +    P  V+ +    V  ++ GS H +  ++DG  V+++G  D G+LG G TN +
Sbjct: 4231 HGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGE-VYTWGDNDEGQLGDGTTNAI 4289

Query: 603  YKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEEL 662
             +P+++ ALQG  + +V  GS  +L         AW        G   A    P     L
Sbjct: 4290 QRPRLVAALQGKKVNRVACGSAHTL---------AWSTSKPASAGKLPAQV--PMEYNHL 4338

Query: 663  AATRIVDVSIGDSHCLALSHDNEVYAWG------NNSMGQCGQGNSTGPITKPKKVSGLD 716
                I+ +    +  L L H +E++           S+ + G G S G  T       L 
Sbjct: 4339 QEIPIIALR---NRLLLLHHLSELFCPCIPMFDLEGSLDETGLGPSVGFDT-------LR 4388

Query: 717  GIAIQQISAGTSHSLAWTALPRDRQ 741
            GI I Q        +    + RDRQ
Sbjct: 4389 GILISQGKEAAFRKVVQATMVRDRQ 4413



 Score =  162 bits (411), Expect = 6e-39
 Identities = 123/402 (30%), Positives = 191/402 (47%), Gaps = 56/402 (13%)

Query: 3889 SLAVGLHLDQLL--CNPPV---PPHHQNCLPDPASWNPNEWAW-------LECFS----- 3931
            ++ V  HLD+L   C PP+   P  H+  L +   W    W +       ++C       
Sbjct: 393  AVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLANLG 452

Query: 3932 -TTIKAAEAL-----TNGAQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWAT 3985
             T I  AE        NG  + +++    L P             + + G+  + +    
Sbjct: 453  VTQIACAEKRFLILSRNGRVYTQAYNSDTLAP-------------QLVQGLASRNIVKIA 499

Query: 3986 SRPEDWH---LGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAP----SFSQAQ------QV 4032
            +  +  H   L    +VY WG G  G+L   G    VP   P    +FS  Q       +
Sbjct: 500  AHSDGHHYLALAATGEVYSWGCGDGGRL---GHGDTVPLEEPKVISAFSGKQAGKHVVHI 556

Query: 4033 ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS-D 4091
             CG   +  I A G +   G G+YGRLG G+S+D  +  +++ L+G  V  +  +CGS D
Sbjct: 557  ACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDV--ACGSGD 614

Query: 4092 GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 4151
              ++A+TE+G+V+SWGDGDYGKLG G SD  + P+ IE LQ  +VV++ CG + S  +T 
Sbjct: 615  AQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTK 674

Query: 4152 DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 4211
            DG+++++G GD  RLG G   + + P+ +  L+G ++  VA G  H LA++ D S V ++
Sbjct: 675  DGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTED-SEVHSW 733

Query: 4212 GDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVA 4253
            G  D  +        K  P  +  L    I  +ACG   S A
Sbjct: 734  GSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFA 775



 Score =  160 bits (404), Expect = 4e-38
 Identities = 109/340 (32%), Positives = 172/340 (50%), Gaps = 24/340 (7%)

Query: 437  LGDSNNQSTLKKLTFEPHRSIKKVSS-------SKGSDGHTLAFTTEGEVFSWGDGDYGK 489
            + DS N   L     E H   K+          ++  D  TL+    G ++ WG    G+
Sbjct: 3909 MADSENMDVLH----ESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQ 3964

Query: 490  LGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSN 549
            LG    +  K P   +     + V  +  G +   AVT DG+LY  G G  GRLG G + 
Sbjct: 3965 LGGIEGAKVKVPTPCEALATLRPVQLI-GGEQTLFAVTADGKLYATGYGAGGRLGIGGTE 4023

Query: 550  SRNIPTLVKDISNV----GEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKP 605
            S + PTL++ I +V      V+ G  H +ALS +G  V+S+G  ++GKLGHG+ +   +P
Sbjct: 4024 SVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGE-VYSWGEAEDGKLGHGNRSPCDRP 4082

Query: 606  KVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEA-TALRPKLIEELAA 664
            +VIE+L+G+ +  V AG   S  +T+ G +Y WG G     G S++   L+PKL+E L  
Sbjct: 4083 RVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQG 4142

Query: 665  TRIVDVSI--GDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQ 722
             R+VD++   GD+  L L+ D+ V++WG+   G+ G+G S G    P K+  L G+ + +
Sbjct: 4143 HRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDG-CKVPMKIDSLTGLGVVK 4201

Query: 723  ISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLR 762
            +  G+  S+   AL +   V  W +     L   +  H+R
Sbjct: 4202 VECGSQFSV---ALTKSGAVYTWGKGDYHRLGHGSDDHVR 4238



 Score =  154 bits (389), Expect = 2e-36
 Identities = 102/285 (35%), Positives = 148/285 (51%), Gaps = 20/285 (7%)

Query: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT------IEAGQYCTFVISTD 421
           ++ T EVY WG     +L  G    + +PK+  +FS  Q       I  G   +  I+ +
Sbjct: 510 LAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAE 569

Query: 422 GSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGS-DGHTLAFTTEGEVF 480
           G +   G+G+YGRLG G S +++    +     + +K +  + GS D  TLA T  G+V+
Sbjct: 570 GELYTWGRGNYGRLGHGSSEDEAI--PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVW 627

Query: 481 SWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF 540
           SWGDGDYGKLG G S   K PKLI+  LQ   VV V  G + S A+T+DG++Y+WG+GD 
Sbjct: 628 SWGDGDYGKLGRGGSDGCKTPKLIE-KLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDN 686

Query: 541 GRLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGD 598
            RLGHG       P L++ +    V +V+ GS+H +AL++D         G N +  H D
Sbjct: 687 QRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEV---HSWGSNDQCQHFD 743

Query: 599 TNRVYKPK--VIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCG 641
           T RV KP+   +  L    I  +  G   S A +S  +   W  G
Sbjct: 744 TLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSE---WSIG 785



 Score =  153 bits (386), Expect = 5e-36
 Identities = 105/280 (37%), Positives = 148/280 (52%), Gaps = 13/280 (4%)

Query: 464  KGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHS 523
            K + G   A T   +VF WG  D  +LG    S  K P   +  L    VV V+ G +  
Sbjct: 2946 KKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSE-TLSALNVVQVAGGSKSL 3004

Query: 524  AAVTEDGELYTWGEGDFGRLGHGDSNS-----RNIPTLVKDISNVGEVSCGSSHTIALSK 578
             AVT +G++Y  GE   GRLG G S+      R I  L   +     V  G  H  AL+ 
Sbjct: 3005 FAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTV 3064

Query: 579  DGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638
            DG+ V+S+G GD+GKLGH       KP++IEAL+   IR +  GS  S ALTS+G++Y W
Sbjct: 3065 DGK-VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTW 3123

Query: 639  GCG--ACLGCGSSEATALRPKLIEELAATRIVDVSIG--DSHCLALSHDNEVYAWGNNSM 694
            G G    LG G +  T L+PK+++ L   R++ V+ G  D+  LAL+ +  V++WG+   
Sbjct: 3124 GLGEYGRLGHGDN-TTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDF 3182

Query: 695  GQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
            G+ G+G S G    P+ +  L+G  + QI  G   SLA T
Sbjct: 3183 GKLGRGGSEG-CNIPQNIERLNGQGVCQIECGAQFSLALT 3221



 Score =  139 bits (350), Expect = 7e-32
 Identities = 96/273 (35%), Positives = 136/273 (49%), Gaps = 6/273 (2%)

Query: 4092 GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 4151
            G   A T   +VF WG  D  +LG     + + P   E L    VVQ++ G K    VT 
Sbjct: 2950 GLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTV 3009

Query: 4152 DGKLFTFGNGDYGRLGLGNTSNK-KLPERVTALEGYQIGQVA--CGLNHTLAVSADGSMV 4208
            +GK++  G    GRLGLG +S    +P ++TAL  Y + +VA   G  H  A++ DG  V
Sbjct: 3010 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGK-V 3068

Query: 4209 WAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRL 4268
            +++G+GD GKLG  +      P+ I+ L    I+ +ACG+  S ALT  G +YT+G    
Sbjct: 3069 FSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3128

Query: 4269 IGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAE--HTLALASNGDVYAWGSNSEGQLGLG 4326
              L  G      +P+ + VL G  +  VA G+    TLAL   G V++WG    G+LG G
Sbjct: 3129 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188

Query: 4327 HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWT 4359
             +     P  +  L G+ V QI  G   S A T
Sbjct: 3189 GSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 3221



 Score =  135 bits (341), Expect = 8e-31
 Identities = 72/208 (34%), Positives = 118/208 (56%), Gaps = 8/208 (3%)

Query: 3998 DVYLWGAGRHGQLAEAGRNVMVPAAAPSF---SQAQQVICGQN--CTFVIQANGTVLACG 4052
            ++Y WG G +G+L        +           +  QV CG     T  +   G V + G
Sbjct: 3119 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 3178

Query: 4053 EGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 4112
            +G +G+LG+G S+  ++   I  L G  V Q+   CG+   S+ALT+SG V++WG GDY 
Sbjct: 3179 DGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQ-FSLALTKSGVVWTWGKGDYF 3235

Query: 4113 KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 4172
            +LGHG+    R+P+ +E L+G+++V ++ G  H   VT  G+++ +G+ D+G+ G G T+
Sbjct: 3236 RLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTT 3295

Query: 4173 NKKLPERVTALEGYQIGQVACGLNHTLA 4200
              + P  V  LEG +I +VACG +H++A
Sbjct: 3296 VNRKPTLVQGLEGQKITRVACGSSHSVA 3323



 Score = 82.8 bits (203), Expect = 8e-15
 Identities = 78/308 (25%), Positives = 133/308 (43%), Gaps = 58/308 (18%)

Query: 16  LNSSWITEDSESIATREGVAVLYSKLVSNKEVV-------------PLPQQVLCLKGPQL 62
           L+S W+  D +   TR+G+  L++++V + E+V             P     +   G + 
Sbjct: 14  LDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPPRKDDSVEPSGTKK 73

Query: 63  PDFERESLSSDEQD--------------------------HYLDALLSSQLALAKMVCSD 96
            D   +    +E+                             L  L+  Q ALA    + 
Sbjct: 74  EDLNDKEKKDEEETPAPIYRAKSILDSWVWGKQPDVNELKECLSVLVKEQQALAVQSATT 133

Query: 97  SPFAGALRKRLLVLQRVFYALSNK-YHDKGKVKQQQHSPESSSGSADVHSVSERPRSS-T 154
           +  A  L++RL++L+R F AL+   + +  KVK +     S      V   S RP     
Sbjct: 134 TLSALRLKQRLVILERYFIALNRTVFQENVKVKWKS----SGISLPPVDKKSSRPAGKGV 189

Query: 155 DALIEMGVRTGLSLLFALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKI 214
           + L  +G R  LS  FA LR++W    SG    LC++++  +++ + +LP  SL +ES +
Sbjct: 190 EGLARVGSRAALSFAFAFLRRAWR---SGEDADLCSELLQESLDALRALPEASLFDESTV 246

Query: 215 PPMGLDCLSQVTTFLKGV-------TIPNSGADTL---GRRLASELLLGLAAQRGSLRYL 264
             + L+ + + T FL+ V       T    G  ++    + LA  +LL LA QRG+L  +
Sbjct: 247 SSVWLEVVERATRFLRSVVTGDVHGTPATKGPGSIPLQDQHLALAILLELAVQRGTLSQM 306

Query: 265 LEWIEMAL 272
           L  I + L
Sbjct: 307 LSAILLLL 314



 Score = 66.6 bits (161), Expect = 6e-10
 Identities = 45/139 (32%), Positives = 72/139 (51%), Gaps = 20/139 (14%)

Query: 4230 PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYT--FGQDRLIGLPEGRARNHNRPQQIPV 4287
            P + + L  +G+ ++AC  +  + L+++G VYT  +  D L             PQ +  
Sbjct: 442  PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTL------------APQLVQG 489

Query: 4288 LAGVIIEDVAVGAE--HTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQ---- 4341
            LA   I  +A  ++  H LALA+ G+VY+WG    G+LG G T  + EP +++       
Sbjct: 490  LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 549

Query: 4342 GKNVRQISAGRCHSAAWTA 4360
            GK+V  I+ G  +SAA TA
Sbjct: 550  GKHVVHIACGSTYSAAITA 568



 Score = 52.8 bits (125), Expect = 8e-06
 Identities = 48/196 (24%), Positives = 86/196 (43%), Gaps = 45/196 (22%)

Query: 1809 TALKVAST-RLLQILAITTGTYADKLSPKVVQSLLDLLCSQLKNLLSQTGVLHMASFGEG 1867
            TA+   ST  LLQ L ++ G +A+ +  +  ++L  LL                      
Sbjct: 1960 TAMMFTSTINLLQTLCLSAGVHAEIMQSEATKTLCGLL---------------------- 1997

Query: 1868 EQEDGEEEEKKVDSSGETEKKDF--RAALRKQHAAELHLGDFLVFLRRVVSSKAIQSKMA 1925
                     + +  SG T+K     R   R+QH +   LG    F+R +  +  +   ++
Sbjct: 1998 ---------RMLVESGTTDKTSSPNRLVYREQHRSWCTLG----FVRSIALTPQVCGALS 2044

Query: 1926 SPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMAQIVERLF 1985
            SP+W  +L+ +             +L+ ++LA+H+L+AVLP+ +       M  +VE+LF
Sbjct: 2045 SPQWITLLMKVVEGHAPF---TATSLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKLF 2101

Query: 1986 ----SLLSDCMWETPI 1997
                SLL+ C  + P+
Sbjct: 2102 DFLGSLLTTCSSDVPL 2117



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 56/225 (24%), Positives = 89/225 (39%), Gaps = 52/225 (23%)

Query: 2196 RDLLPGDPICSPVAAVLAEATIQLIRILHRTDRWTYCINKKMMERLHKIKICIKESGQKL 2255
            R + P   + +  ++ LAE  + L+R LH   +W   INK +  +L  I           
Sbjct: 2126 RRVRPQASLTATHSSTLAEEVVALLRTLHSLTQWNGLINKYINSQLRSI----------- 2174

Query: 2256 KKSRSVQSREENEMREEK---ESKEEEKGKHTRHGLADLSELQLRTLCIEVWPVLAVIGG 2312
              + S   R     + E    +S+  E G                     +  VLAVIGG
Sbjct: 2175 --THSFVGRPSEGAQLEDYFPDSENPEVGG--------------------LMAVLAVIGG 2212

Query: 2313 VDAGLRVGGRCVHKQTGRHATLLGVVKEGSTSAKVQWDEAEITISFPTFWSPSDTPLYNL 2372
            +D  LR+GG+ +H + G   T+  +  +G           +IT+ F    +    PL  L
Sbjct: 2213 IDGRLRLGGQVMHDEFG-EGTVTRITPKG-----------KITVQFSDMRTCRVCPLNQL 2260

Query: 2373 EPCEPLPFDVAR--FRGLTASVLLDLTYLTG--VHEDMGKQSTKR 2413
            +P   + F+V    F     SV   L  L G  + +   K+STK+
Sbjct: 2261 KPLPAVAFNVNNLPFTEPMLSVWAQLVNLAGSKLEKHKIKKSTKQ 2305



 Score = 42.4 bits (98), Expect = 0.011
 Identities = 41/137 (29%), Positives = 61/137 (44%), Gaps = 14/137 (10%)

Query: 2705 SSLPTSPSDEVGRRQSLTSPDS-QSARPANRTALSDPSSRLSTSPPPPA-IAVPLLEMGF 2762
            S+ P+SP  E       T+P + Q  RPA          R   SP P   I V L+EMGF
Sbjct: 2418 STHPSSPGFEDCSSSEATTPVAVQHIRPAR-------VKRRKQSPVPALPIVVQLMEMGF 2470

Query: 2763 SLRQIAKAMEA-TGARGEADA-QNITVLAMWMIEHPGHEDEEEPQSGSTADSRPGAAVLG 2820
            S R I  A+++ TGA G A +   +  L  W+++H   +  E   + + +D      V+ 
Sbjct: 2471 SRRNIEFALKSLTGASGNASSLPGVEALVGWLLDHSDIQVTELSDADTVSDEYSDEEVVE 2530

Query: 2821 SGGKSNDPCYLQSPGDI 2837
                 +D  Y  S G +
Sbjct: 2531 D---VDDAAYSMSTGAV 2544



 Score = 38.9 bits (89), Expect = 0.13
 Identities = 16/46 (34%), Positives = 29/46 (63%)

Query: 1138 LVDLERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVE 1183
            L+D ER + LL+G     +   +P+SP E + A W+++ +FS G++
Sbjct: 1302 LIDTERNLGLLLGLHASYLAMSTPLSPVEIECAKWLQSSIFSGGLQ 1347



 Score = 37.0 bits (84), Expect = 0.48
 Identities = 20/56 (35%), Positives = 29/56 (51%)

Query: 3366 LANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCSF 3421
            LA +LAAC   S L++ HR WA Q+L + L      +    + L +  G+ R  SF
Sbjct: 3753 LAASLAACAQLSALAASHRMWALQRLRKLLTTEFGQSININRLLGENDGETRALSF 3808


>gi|157738609 HECT domain containing 3 [Homo sapiens]
          Length = 861

 Score =  196 bits (499), Expect = 4e-49
 Identities = 127/351 (36%), Positives = 191/351 (54%), Gaps = 23/351 (6%)

Query: 4504 DLRLPSRA---WKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSP------NAT 4554
            D R P R    W+ K + EG  D GG F D++ +M +EL     D  +P P      N  
Sbjct: 517  DYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQG 576

Query: 4555 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLT 4614
               G  RD ++ NPS C D    +++++G LMG A+R K+ L L L   VWKQL    ++
Sbjct: 577  NGTGEARDMYVPNPS-CRD--FAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVS 633

Query: 4615 L-EDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLD-SFVGQSADGKMVPIIPGGNS 4672
              +D   VD + V+ L  +      G+ +E+F      + +F    +D ++V +IPGG  
Sbjct: 634  WSKDFPAVDSVLVKLLEVM-----EGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAG 688

Query: 4673 IPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPE 4732
            I + + +R  +++   + RL E   QVAA++ G+  +VP  +L LLT ++LE+ VCG PE
Sbjct: 689  IVVGYGDRSRFIQLVQKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPE 748

Query: 4733 ISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR 4792
            ++V+ L+K+ R+ + +     VQ+FW  L  F+NE+R  F+RFV+GRSRLPA       +
Sbjct: 749  VTVDALRKLTRFEDFEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPDK 808

Query: 4793 FQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMD 4843
                      D+LP S TC   L LP Y+S  V  E+LRYA  NC +ID D
Sbjct: 809  LGY----ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score =  181 bits (460), Expect = 1e-44
 Identities = 119/357 (33%), Positives = 188/357 (52%), Gaps = 17/357 (4%)

Query: 4002 WGAGRHGQLAEAGRNVMVPAAAPSFSQ--AQQVICGQNCTFVIQANGTVLACGEGSYGRL 4059
            W  G+ G        V  P      S    ++V CG N +  +  +G V  CG  + G+L
Sbjct: 7    WSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQL 66

Query: 4060 G---QGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG- 4115
            G   +GN  +      I AL    +  +  +CG + HS+AL++ G++FSWG G  G+LG 
Sbjct: 67   GHEREGNKPEQ-----IGALADQHIIHV--ACG-ESHSLALSDRGQLFSWGAGSDGQLGL 118

Query: 4116 HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SNK 4174
                D    PR I+ L  + ++Q+SCG  H   + +DG+ FT+G   +G+LGLG    ++
Sbjct: 119  MTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQ 178

Query: 4175 KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKID 4234
              P+RV +LEG  + QVA G  H+ A+S  G+ V+ +G  + G+LGL +   + SP  + 
Sbjct: 179  ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA-VFGWGMNNAGQLGLSDEKDRESPCHVK 237

Query: 4235 VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIE 4294
            +L    +  ++CG + +  LTK G V+TFG      L      +   P+++  L G  + 
Sbjct: 238  LLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVT 297

Query: 4295 DVAVGAEHTLALA-SNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISA 4350
             +A G +HTLA   S+G +YA+G  + GQLG GHT +V+ P+ V G    +  Q+SA
Sbjct: 298  QIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSA 354



 Score =  157 bits (396), Expect = 3e-37
 Identities = 111/331 (33%), Positives = 169/331 (51%), Gaps = 9/331 (2%)

Query: 4056 YGRLGQ-GNSDDLHVLTVISALQGFVVTQLV--TSCGSDGHSMALTESGEVFSWGDGDYG 4112
            Y  LGQ G S +L  +     + GF+  + V   +CG + HS+ L E GEV++ G    G
Sbjct: 6    YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGN-HSVFLLEDGEVYTCGLNTKG 64

Query: 4113 KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 4172
            +LGH       +P QI AL  + ++ ++CG  HS  ++  G+LF++G G  G+LGL  T 
Sbjct: 65   QLGHEREGN--KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 122

Query: 4173 NK-KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNS-TAKSSP 4230
            +   +P  +  L    I QV+CG  H LA++ADG   + +G   +G+LGLG    +++SP
Sbjct: 123  DSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF-FTWGKNSHGQLGLGKEFPSQASP 181

Query: 4231 QKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAG 4290
            Q++  L GI + +VA G   S AL+  G V+ +G +    L     ++   P  + +L  
Sbjct: 182  QRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRT 241

Query: 4291 VIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISA 4350
              +  ++ G EHT  L  +G V+ +G+ S GQLG    N    P  V  L G  V QI+ 
Sbjct: 242  QKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIAC 301

Query: 4351 GRCHSAAWTAPPVPPRAPGVSVPLQLGLPDT 4381
            GR H+ A+        A G     QLG   T
Sbjct: 302  GRQHTLAFVPSSGLIYAFGCGARGQLGTGHT 332



 Score =  139 bits (351), Expect = 5e-32
 Identities = 85/262 (32%), Positives = 132/262 (50%), Gaps = 8/262 (3%)

Query: 3977 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA--EAGRNVMVPAAAPSFSQAQ--QV 4032
            D+ I+  A        L  +  ++ WGAG  GQL       +V VP      +Q    QV
Sbjct: 83   DQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQV 142

Query: 4033 ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 4091
             CG      + A+G     G+ S+G+LG G           + +L+G  + Q+       
Sbjct: 143  SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---G 199

Query: 4092 GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 4151
             HS AL+ SG VF WG  + G+LG  +   +  P  ++ L+ ++VV +SCG +H+AV+T 
Sbjct: 200  AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTK 259

Query: 4152 DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 4211
             G +FTFG G  G+LG  + +++  P RV  L G ++ Q+ACG  HTLA      +++AF
Sbjct: 260  SGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAF 319

Query: 4212 GDGDYGKLGLGNSTAKSSPQKI 4233
            G G  G+LG G++     P  +
Sbjct: 320  GCGARGQLGTGHTCNVKCPSPV 341



 Score =  131 bits (330), Expect = 1e-29
 Identities = 92/314 (29%), Positives = 163/314 (51%), Gaps = 20/314 (6%)

Query: 432 YGRLGLGDSNNQSTLKKLTFEPH-------RSIKKVSSSKGSDGHTLAFTTEGEVFSWGD 484
           +G   LG     + L+ +  EP        RS+K+V+       H++    +GEV++ G 
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG---GNHSVFLLEDGEVYTCGL 60

Query: 485 GDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544
              G+LGH     +  P+ I G L  + ++ V+ G  HS A+++ G+L++WG G  G+LG
Sbjct: 61  NTKGQLGHEREGNK--PEQI-GALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117

Query: 545 -HGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHG-DTN 600
                +S  +P L++ ++   + +VSCG+ H +AL+ DG+  +++G   +G+LG G +  
Sbjct: 118 LMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ-FFTWGKNSHGQLGLGKEFP 176

Query: 601 RVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLI 659
               P+ + +L+G+ + +V AG   S AL+ +G V+ WG       G S E     P  +
Sbjct: 177 SQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHV 236

Query: 660 EELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIA 719
           + L   ++V +S G+ H   L+    V+ +G  S GQ G  +    +  P++V  L G  
Sbjct: 237 KLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVN-PRRVLELMGSE 295

Query: 720 IQQISAGTSHSLAW 733
           + QI+ G  H+LA+
Sbjct: 296 VTQIACGRQHTLAF 309



 Score =  130 bits (327), Expect = 3e-29
 Identities = 98/311 (31%), Positives = 158/311 (50%), Gaps = 23/311 (7%)

Query: 342 EVCRMASDYSR---TCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKL 398
           +VC   SD S     C    S+       + E  EVY  G N+  QL  G + +  +P+ 
Sbjct: 26  QVCGFISDRSVKEVACGGNHSV------FLLEDGEVYTCGLNTKGQL--GHEREGNKPEQ 77

Query: 399 APSFSDAQTIEA--GQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHR- 455
             + +D   I    G+  +  +S  G + + G GS G+LGL  + +   + +L  + ++ 
Sbjct: 78  IGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQ 137

Query: 456 SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNS-STQKYPKLIQGPLQGKVVV 514
           +I +VS     + H LA   +G+ F+WG   +G+LG G    +Q  P+ ++  L+G  + 
Sbjct: 138 TILQVSCG---NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLA 193

Query: 515 CVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSH 572
            V+AG  HS A++  G ++ WG  + G+LG  D   R  P  VK +    V  +SCG  H
Sbjct: 194 QVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEH 253

Query: 573 TIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLA-LTS 631
           T  L+K G  V++FG G  G+LGH   N    P+ +  L G  + ++  G Q +LA + S
Sbjct: 254 TAVLTKSGG-VFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPS 312

Query: 632 TGQVYAWGCGA 642
           +G +YA+GCGA
Sbjct: 313 SGLIYAFGCGA 323



 Score =  128 bits (321), Expect = 2e-28
 Identities = 101/360 (28%), Positives = 168/360 (46%), Gaps = 20/360 (5%)

Query: 377 WGSNSSHQ--LVEGTQEKILQPKLAPSFSDAQTIEA---GQYCTFVISTDGSVRACGKGS 431
           WG  S  Q  +    Q  + +P++    SD    E    G +  F++  DG V  CG  +
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLE-DGEVYTCGLNT 62

Query: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491
            G+LG     N+        + H     +      + H+LA +  G++FSWG G  G+LG
Sbjct: 63  KGQLGHEREGNKPEQIGALADQH-----IIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117

Query: 492 -HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHG-DSN 549
                 +   P+LIQ  L  + ++ VS G  H  A+  DG+ +TWG+   G+LG G +  
Sbjct: 118 LMTTEDSVAVPRLIQ-KLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFP 176

Query: 550 SRNIPTLVKDISNV--GEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKV 607
           S+  P  V+ +  +   +V+ G +H+ ALS  G  V+ +G  + G+LG  D      P  
Sbjct: 177 SQASPQRVRSLEGIPLAQVAAGGAHSFALSLSG-AVFGWGMNNAGQLGLSDEKDRESPCH 235

Query: 608 IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLIEELAATR 666
           ++ L+   +  +  G + +  LT +G V+ +G G+C   G  S    + P+ + EL  + 
Sbjct: 236 VKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSE 295

Query: 667 IVDVSIGDSHCLA-LSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISA 725
           +  ++ G  H LA +     +YA+G  + GQ G G+ T  +  P  V G       Q+SA
Sbjct: 296 VTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGH-TCNVKCPSPVKGYWAAHSGQLSA 354



 Score =  113 bits (282), Expect = 5e-24
 Identities = 71/250 (28%), Positives = 134/250 (53%), Gaps = 14/250 (5%)

Query: 368 VSETCEVYVWGSNSSHQL-VEGTQEKILQPKLAPSFSDAQTIEA--GQYCTFVISTDGSV 424
           +S+  +++ WG+ S  QL +  T++ +  P+L    +    ++   G +    ++ DG  
Sbjct: 99  LSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF 158

Query: 425 RACGKGSYGRLGLG-DSNNQSTLKKLTFEPHRSIKKVSSSKGSDG--HTLAFTTEGEVFS 481
              GK S+G+LGLG +  +Q++ +++     RS++ +  ++ + G  H+ A +  G VF 
Sbjct: 159 FTWGKNSHGQLGLGKEFPSQASPQRV-----RSLEGIPLAQVAAGGAHSFALSLSGAVFG 213

Query: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFG 541
           WG  + G+LG  +   ++ P  ++  L+ + VV +S G  H+A +T+ G ++T+G G  G
Sbjct: 214 WGMNNAGQLGLSDEKDRESPCHVK-LLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCG 272

Query: 542 RLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDT 599
           +LGH   N    P  V ++  S V +++CG  HT+A       +++FG G  G+LG G T
Sbjct: 273 QLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHT 332

Query: 600 NRVYKPKVIE 609
             V  P  ++
Sbjct: 333 CNVKCPSPVK 342



 Score =  107 bits (267), Expect = 3e-22
 Identities = 92/337 (27%), Positives = 150/337 (44%), Gaps = 23/337 (6%)

Query: 4504 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 4563
            DL+ P    KV   GE A DAGGV  +    + +EL   I  +            Y    
Sbjct: 726  DLKKPL---KVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMF---------TYYQDSN 773

Query: 4564 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDL 4623
             L+    C  EH   F  +GI  G+AI     +DLH    ++K+L  V   LEDL+E+  
Sbjct: 774  LLWFSDTCFVEHNW-FHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSP 832

Query: 4624 LYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADG--KMVPIIPGGNSIPLTFSNRK 4681
               ++L  +L         E   E   L+  + + + G  +   +IPGG+++ +   NR+
Sbjct: 833  TEGRSLQELLDYPG-----EDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQ 887

Query: 4682 EYVERAIEYRLH-EMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKK 4740
            E+V+  + Y     +     A   G   +    +L L    +L  M+ G    + E L++
Sbjct: 888  EFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEE 947

Query: 4741 VVRYR-EVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVD 4799
               Y+ +    H  V+ FW T  EF  E++  F+ F++G  R+P      S +  I    
Sbjct: 948  TAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPI-YGMASLQIVIQSTA 1006

Query: 4800 RPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 4836
               + LP + TC+  L LP YSS+ +++ RL  A++N
Sbjct: 1007 SGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDN 1043



 Score =  105 bits (263), Expect = 8e-22
 Identities = 80/260 (30%), Positives = 121/260 (46%), Gaps = 12/260 (4%)

Query: 482 WGDGDYGKLGHGNSSTQKYPKLIQ----GPLQGKVVVCVSAGYRHSAAVTEDGELYTWGE 537
           WG   Y  LG    ST     + +    G +  + V  V+ G  HS  + EDGE+YT G 
Sbjct: 4   WG---YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60

Query: 538 GDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHG 597
              G+LGH    ++          ++  V+CG SH++ALS  G+ ++S+G G +G+LG  
Sbjct: 61  NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQ-LFSWGAGSDGQLGLM 119

Query: 598 DT-NRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGAC--LGCGSSEATAL 654
            T + V  P++I+ L    I +V  G+   LAL + GQ + WG  +   LG G    +  
Sbjct: 120 TTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 179

Query: 655 RPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSG 714
            P+ +  L    +  V+ G +H  ALS    V+ WG N+ GQ G  +       P  V  
Sbjct: 180 SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDR-ESPCHVKL 238

Query: 715 LDGIAIQQISAGTSHSLAWT 734
           L    +  IS G  H+   T
Sbjct: 239 LRTQKVVYISCGEEHTAVLT 258



 Score = 69.7 bits (169), Expect = 7e-11
 Identities = 45/144 (31%), Positives = 68/144 (47%), Gaps = 4/144 (2%)

Query: 602 VYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEE 661
           V +P+V   +    +++V  G   S+ L   G+VY  G     G    E    +P+ I  
Sbjct: 22  VAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNT-KGQLGHEREGNKPEQIGA 80

Query: 662 LAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQ 721
           LA   I+ V+ G+SH LALS   ++++WG  S GQ G   +   +  P+ +  L+   I 
Sbjct: 81  LADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTIL 140

Query: 722 QISAGTSHSLAWTALPRDRQVVAW 745
           Q+S G  H L   AL  D Q   W
Sbjct: 141 QVSCGNWHCL---ALAADGQFFTW 161


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score =  170 bits (430), Expect = 4e-41
 Identities = 110/346 (31%), Positives = 176/346 (50%), Gaps = 14/346 (4%)

Query: 4002 WGAGRHGQLAEAGRN---VMVPAAAPSF--SQAQQVICGQNCTFVIQANGTVLACGEGSY 4056
            WG    GQL   G +   V+ P  +  F   + + V CG   T  +  +GTV  CG    
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 4057 GRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGH 4116
            G+LG   S       V    Q  V      SCG + H++AL + G+V++WG    G+LG 
Sbjct: 64   GQLGHEKSRKKPEQVVALDAQNIVAV----SCG-EAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 4117 -GNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK 4175
             G+ +  R PR I++L   ++VQ++CG+ HS  ++   ++F +G   YG+LGLG    K+
Sbjct: 119  VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQ 178

Query: 4176 L-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKID 4234
              P+ + +L G    QVA G  H+  ++  G+ ++ +G   +G+LGL +   +  P  + 
Sbjct: 179  TSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA-IFGWGRNKFGQLGLNDENDRYVPNLLK 237

Query: 4235 VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIE 4294
             L    I  + CG   + ALTK+G V+TFG      L      +   P+++  L G I+ 
Sbjct: 238  SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVT 297

Query: 4295 DVAVGAEHTLALA-SNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG 4339
            ++A G +HT A   S+G +Y++G    GQLG G T++ + P  V G
Sbjct: 298  EIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343



 Score =  161 bits (407), Expect = 2e-38
 Identities = 104/314 (33%), Positives = 164/314 (52%), Gaps = 8/314 (2%)

Query: 4048 VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 4106
            +L  G  S+G+LG G  D+  VL    +   F + + V   G    H++ + + G V++ 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKS--DFFINKRVRDVGCGLRHTVFVLDDGTVYTC 58

Query: 4107 GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 4166
            G  D G+LGH  S  +++P Q+ AL  + +V +SCG  H+  +   G+++ +G    G+L
Sbjct: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQL 116

Query: 4167 GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 4225
            GL G+    ++P  + +L   QI QVACG  H+LA+S   S V+ +G   YG+LGLG   
Sbjct: 117  GLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGTDC 175

Query: 4226 AK-SSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 4284
             K +SPQ +  L GI   +VA G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 176  KKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 4285 IPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKN 4344
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 236  LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 4345 VRQISAGRCHSAAW 4358
            V +I+ GR H++A+
Sbjct: 296  VTEIACGRQHTSAF 309



 Score =  148 bits (373), Expect = 1e-34
 Identities = 91/258 (35%), Positives = 136/258 (52%), Gaps = 7/258 (2%)

Query: 4106 WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 4163
            WG+  +G+LG G  D +    PR+ +    + V  + CG +H+  V  DG ++T G  D 
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 4164 GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 4222
            G+LG  +  ++K PE+V AL+   I  V+CG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLVG 120

Query: 4223 NSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGR-ARNHNR 4281
            +      P+ I  L  I I +VACG   S+AL+K   V+ +GQ++   L  G   +    
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180

Query: 4282 PQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQ 4341
            PQ +  L G+    VA G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 4342 GKNVRQISAGRCHSAAWT 4359
             + +  I  G  H+AA T
Sbjct: 241  SQKIVYICCGEDHTAALT 258



 Score =  140 bits (353), Expect = 3e-32
 Identities = 97/313 (30%), Positives = 162/313 (51%), Gaps = 15/313 (4%)

Query: 428 GKGSYGRLGLGDSNNQSTL--KKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDG 485
           G  S+G+LGLG  + +  L  +K  F  ++ ++ V        HT+    +G V++ G  
Sbjct: 5   GNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLR---HTVFVLDDGTVYTCGCN 61

Query: 486 DYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG- 544
           D G+LGH  S  +K P+ +   L  + +V VS G  H+ A+ + G++Y WG    G+LG 
Sbjct: 62  DLGQLGHEKS--RKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 545 HGDSNSRNIPTLVKDISNVG--EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHG-DTNR 601
            G      +P  +K +S++   +V+CG  H++ALSK    V+ +G    G+LG G D  +
Sbjct: 119 VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGTDCKK 177

Query: 602 VYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLIE 660
              P+++++L G+   +V AG   S  LT +G ++ WG       G + E     P L++
Sbjct: 178 QTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLK 237

Query: 661 ELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI 720
            L + +IV +  G+ H  AL+ +  V+ +G    GQ G  NST     P+KV  L G  +
Sbjct: 238 SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH-NSTSHEINPRKVFELMGSIV 296

Query: 721 QQISAGTSHSLAW 733
            +I+ G  H+ A+
Sbjct: 297 TEIACGRQHTSAF 309



 Score =  140 bits (352), Expect = 4e-32
 Identities = 80/242 (33%), Positives = 122/242 (50%), Gaps = 6/242 (2%)

Query: 3993 LGGKCDVYLWGAGRHGQLAEAGRN--VMVPAAAPSFSQAQ--QVICGQNCTFVIQANGTV 4048
            L  K  VY WG    GQL   G    + VP    S S  Q  QV CG   +  +     V
Sbjct: 99   LNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEV 158

Query: 4049 LACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGD 4108
               G+  YG+LG G   D    T    L+  +    +       HS  LT SG +F WG 
Sbjct: 159  FCWGQNKYGQLGLGT--DCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216

Query: 4109 GDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGL 4168
              +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G +FTFG G YG+LG 
Sbjct: 217  NKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276

Query: 4169 GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 4228
             +TS++  P +V  L G  + ++ACG  HT A       +++FG G  G+LG G+++ + 
Sbjct: 277  NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336

Query: 4229 SP 4230
            SP
Sbjct: 337  SP 338



 Score =  137 bits (344), Expect = 3e-31
 Identities = 99/349 (28%), Positives = 175/349 (50%), Gaps = 20/349 (5%)

Query: 377 WGSNSSHQLVEG--TQEKILQPKLAPSFSDAQTIEAG---QYCTFVISTDGSVRACGKGS 431
           WG+ S  QL  G   +E +L+P+ +  F + +  + G   ++  FV+  DG+V  CG   
Sbjct: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLD-DGTVYTCGCND 62

Query: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491
            G+LG     ++ + KK         + + +    + HTLA   +G+V++WG    G+LG
Sbjct: 63  LGQLG-----HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117

Query: 492 -HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHG-DSN 549
             G+    + P+ I+  L    +V V+ GY HS A+++  E++ WG+  +G+LG G D  
Sbjct: 118 LVGSEECIRVPRNIKS-LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCK 176

Query: 550 SRNIPTLVKDISNVG--EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKV 607
            +  P L+K +  +   +V+ G +H+  L+  G  ++ +G    G+LG  D N  Y P +
Sbjct: 177 KQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSG-AIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 608 IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLIEELAATR 666
           +++L+   I  +C G   + ALT  G V+ +G G     G +S +  + P+ + EL  + 
Sbjct: 236 LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 667 IVDVSIGDSHCLA-LSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSG 714
           + +++ G  H  A +     +Y++G    GQ G G ST     P  V G
Sbjct: 296 VTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG-STSNRKSPFTVKG 343



 Score =  133 bits (335), Expect = 4e-30
 Identities = 91/284 (32%), Positives = 143/284 (50%), Gaps = 14/284 (4%)

Query: 374 VYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYG 433
           VY  G N   QL      K  +  +A    +   +  G+  T  ++  G V A G  S G
Sbjct: 55  VYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDG 114

Query: 434 RLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG--HTLAFTTEGEVFSWGDGDYGKLG 491
           +LGL  S     + +      +S+  +   + + G  H+LA +   EVF WG   YG+LG
Sbjct: 115 QLGLVGSEECIRVPRNI----KSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170

Query: 492 HG-NSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNS 550
            G +   Q  P+L++  L G   + V+AG  HS  +T  G ++ WG   FG+LG  D N 
Sbjct: 171 LGTDCKKQTSPQLLKS-LLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229

Query: 551 RNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVI 608
           R +P L+K +    +  + CG  HT AL+K+G  V++FG G  G+LGH  T+    P+ +
Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTKEG-GVFTFGAGGYGQLGHNSTSHEINPRKV 288

Query: 609 EALQGMFIRKVCAGSQ-SSLALTSTGQVYAWGCG--ACLGCGSS 649
             L G  + ++  G Q +S  + S+G++Y++G G    LG GS+
Sbjct: 289 FELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST 332



 Score =  127 bits (320), Expect = 2e-28
 Identities = 78/246 (31%), Positives = 126/246 (51%), Gaps = 16/246 (6%)

Query: 373 EVYVWGSNSSHQL-VEGTQEKILQPKLAPSFSDAQTIEA--GQYCTFVISTDGSVRACGK 429
           +VY WG +S  QL + G++E I  P+   S SD Q ++   G Y +  +S    V   G+
Sbjct: 104 QVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQ 163

Query: 430 GSYGRLGLGDSNNQST----LKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDG 485
             YG+LGLG    + T    LK L   P   +           H+   T  G +F WG  
Sbjct: 164 NKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVA------AGGAHSFVLTLSGAIFGWGRN 217

Query: 486 DYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGH 545
            +G+LG  + + +  P L++  L+ + +V +  G  H+AA+T++G ++T+G G +G+LGH
Sbjct: 218 KFGQLGLNDENDRYVPNLLKS-LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276

Query: 546 GDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVY 603
             ++    P  V ++  S V E++CG  HT A       ++SFG G NG+LG G T+   
Sbjct: 277 NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336

Query: 604 KPKVIE 609
            P  ++
Sbjct: 337 SPFTVK 342



 Score =  119 bits (299), Expect = 6e-26
 Identities = 80/261 (30%), Positives = 124/261 (47%), Gaps = 14/261 (5%)

Query: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQG-----KVVVCVSAGYRHSAAVTEDGELYTWG 536
           WG+  +G+LG G    +    ++  P +      K V  V  G RH+  V +DG +YT G
Sbjct: 4   WGNASFGQLGLGGIDEE----IVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCG 59

Query: 537 EGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLG- 595
             D G+LGH  S  +    +  D  N+  VSCG +HT+AL+  G+ V+++G   +G+LG 
Sbjct: 60  CNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQ-VYAWGLDSDGQLGL 118

Query: 596 HGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCG--ACLGCGSSEATA 653
            G    +  P+ I++L  + I +V  G   SLAL+   +V+ WG      LG G+     
Sbjct: 119 VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQ 178

Query: 654 LRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVS 713
             P+L++ L     + V+ G +H   L+    ++ WG N  GQ G  N       P  + 
Sbjct: 179 TSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-NDENDRYVPNLLK 237

Query: 714 GLDGIAIQQISAGTSHSLAWT 734
            L    I  I  G  H+ A T
Sbjct: 238 SLRSQKIVYICCGEDHTAALT 258



 Score =  114 bits (285), Expect = 2e-24
 Identities = 71/225 (31%), Positives = 119/225 (52%), Gaps = 10/225 (4%)

Query: 3958 VPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAG--R 4015
            V  +E + +  N K ++  D QI+  A        L    +V+ WG  ++GQL      +
Sbjct: 119  VGSEECIRVPRNIKSLS--DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCK 176

Query: 4016 NVMVPAAAPSF--SQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVI 4073
                P    S       QV  G   +FV+  +G +   G   +G+LG  + +D +V  ++
Sbjct: 177  KQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLL 236

Query: 4074 SALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQG 4133
             +L+     ++V  C  + H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G
Sbjct: 237  KSLRS---QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMG 293

Query: 4134 EEVVQMSCGFKH-SAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLP 4177
              V +++CG +H SA V S G++++FG G  G+LG G+TSN+K P
Sbjct: 294  SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338



 Score =  103 bits (257), Expect = 4e-21
 Identities = 72/198 (36%), Positives = 108/198 (54%), Gaps = 14/198 (7%)

Query: 368 VSETCEVYVWGSNSSHQLVEGTQ-EKILQPKLAPSFSDA--QTIEAGQYCTFVISTDGSV 424
           +S+  EV+ WG N   QL  GT  +K   P+L  S        + AG   +FV++  G++
Sbjct: 152 LSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAI 211

Query: 425 RACGKGSYGRLGLGDSNNQ---STLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481
              G+  +G+LGL D N++   + LK L     RS K V    G D HT A T EG VF+
Sbjct: 212 FGWGRNKFGQLGLNDENDRYVPNLLKSL-----RSQKIVYICCGED-HTAALTKEGGVFT 265

Query: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRH-SAAVTEDGELYTWGEGDF 540
           +G G YG+LGH ++S +  P+ +   L G +V  ++ G +H SA V   G +Y++G G  
Sbjct: 266 FGAGGYGQLGHNSTSHEINPRKV-FELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGN 324

Query: 541 GRLGHGDSNSRNIPTLVK 558
           G+LG G +++R  P  VK
Sbjct: 325 GQLGTGSTSNRKSPFTVK 342



 Score = 82.8 bits (203), Expect = 8e-15
 Identities = 83/329 (25%), Positives = 147/329 (44%), Gaps = 22/329 (6%)

Query: 4513 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 4571
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 731  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 781

Query: 4572 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNS 4631
             D  L  F  +G++ G+AI     +DLH    ++K+L     +L+DL+E+     +++  
Sbjct: 782  EDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQ 839

Query: 4632 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 4689
            +L   +  I EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 840  LLDYPEDDI-EETFCLNFTITVENF----GATEVKELVLNGADTAVNKQNRQEFVDAYVD 894

Query: 4690 YRLHEMDRQV-AAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 4747
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 895  YIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 954

Query: 4748 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 4807
              +H  ++ FW    E   E++  F+ F++G  R+P      S +  I       + LP 
Sbjct: 955  WAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLKLVIQSTGGGEEYLPV 1013

Query: 4808 SQTCFFQLRLPPYSSQLVMAERLRYAINN 4836
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 1014 SHTCFNLLDLPKYTEKETLRSKLIQAIDH 1042


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score =  170 bits (430), Expect = 4e-41
 Identities = 110/346 (31%), Positives = 176/346 (50%), Gaps = 14/346 (4%)

Query: 4002 WGAGRHGQLAEAGRN---VMVPAAAPSF--SQAQQVICGQNCTFVIQANGTVLACGEGSY 4056
            WG    GQL   G +   V+ P  +  F   + + V CG   T  +  +GTV  CG    
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 4057 GRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGH 4116
            G+LG   S       V    Q  V      SCG + H++AL + G+V++WG    G+LG 
Sbjct: 64   GQLGHEKSRKKPEQVVALDAQNIVAV----SCG-EAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 4117 -GNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK 4175
             G+ +  R PR I++L   ++VQ++CG+ HS  ++   ++F +G   YG+LGLG    K+
Sbjct: 119  VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQ 178

Query: 4176 L-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKID 4234
              P+ + +L G    QVA G  H+  ++  G+ ++ +G   +G+LGL +   +  P  + 
Sbjct: 179  TSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA-IFGWGRNKFGQLGLNDENDRYVPNLLK 237

Query: 4235 VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIE 4294
             L    I  + CG   + ALTK+G V+TFG      L      +   P+++  L G I+ 
Sbjct: 238  SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVT 297

Query: 4295 DVAVGAEHTLALA-SNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG 4339
            ++A G +HT A   S+G +Y++G    GQLG G T++ + P  V G
Sbjct: 298  EIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343



 Score =  161 bits (407), Expect = 2e-38
 Identities = 104/314 (33%), Positives = 164/314 (52%), Gaps = 8/314 (2%)

Query: 4048 VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 4106
            +L  G  S+G+LG G  D+  VL    +   F + + V   G    H++ + + G V++ 
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKS--DFFINKRVRDVGCGLRHTVFVLDDGTVYTC 58

Query: 4107 GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 4166
            G  D G+LGH  S  +++P Q+ AL  + +V +SCG  H+  +   G+++ +G    G+L
Sbjct: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQL 116

Query: 4167 GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 4225
            GL G+    ++P  + +L   QI QVACG  H+LA+S   S V+ +G   YG+LGLG   
Sbjct: 117  GLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGTDC 175

Query: 4226 AK-SSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 4284
             K +SPQ +  L GI   +VA G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 176  KKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 4285 IPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKN 4344
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 236  LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 4345 VRQISAGRCHSAAW 4358
            V +I+ GR H++A+
Sbjct: 296  VTEIACGRQHTSAF 309



 Score =  148 bits (373), Expect = 1e-34
 Identities = 91/258 (35%), Positives = 136/258 (52%), Gaps = 7/258 (2%)

Query: 4106 WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 4163
            WG+  +G+LG G  D +    PR+ +    + V  + CG +H+  V  DG ++T G  D 
Sbjct: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 4164 GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 4222
            G+LG  +  ++K PE+V AL+   I  V+CG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLVG 120

Query: 4223 NSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGR-ARNHNR 4281
            +      P+ I  L  I I +VACG   S+AL+K   V+ +GQ++   L  G   +    
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180

Query: 4282 PQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQ 4341
            PQ +  L G+    VA G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 4342 GKNVRQISAGRCHSAAWT 4359
             + +  I  G  H+AA T
Sbjct: 241  SQKIVYICCGEDHTAALT 258



 Score =  140 bits (353), Expect = 3e-32
 Identities = 97/313 (30%), Positives = 162/313 (51%), Gaps = 15/313 (4%)

Query: 428 GKGSYGRLGLGDSNNQSTL--KKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDG 485
           G  S+G+LGLG  + +  L  +K  F  ++ ++ V        HT+    +G V++ G  
Sbjct: 5   GNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLR---HTVFVLDDGTVYTCGCN 61

Query: 486 DYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG- 544
           D G+LGH  S  +K P+ +   L  + +V VS G  H+ A+ + G++Y WG    G+LG 
Sbjct: 62  DLGQLGHEKS--RKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118

Query: 545 HGDSNSRNIPTLVKDISNVG--EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHG-DTNR 601
            G      +P  +K +S++   +V+CG  H++ALSK    V+ +G    G+LG G D  +
Sbjct: 119 VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGTDCKK 177

Query: 602 VYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLIE 660
              P+++++L G+   +V AG   S  LT +G ++ WG       G + E     P L++
Sbjct: 178 QTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLK 237

Query: 661 ELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI 720
            L + +IV +  G+ H  AL+ +  V+ +G    GQ G  NST     P+KV  L G  +
Sbjct: 238 SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH-NSTSHEINPRKVFELMGSIV 296

Query: 721 QQISAGTSHSLAW 733
            +I+ G  H+ A+
Sbjct: 297 TEIACGRQHTSAF 309



 Score =  140 bits (352), Expect = 4e-32
 Identities = 80/242 (33%), Positives = 122/242 (50%), Gaps = 6/242 (2%)

Query: 3993 LGGKCDVYLWGAGRHGQLAEAGRN--VMVPAAAPSFSQAQ--QVICGQNCTFVIQANGTV 4048
            L  K  VY WG    GQL   G    + VP    S S  Q  QV CG   +  +     V
Sbjct: 99   LNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEV 158

Query: 4049 LACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGD 4108
               G+  YG+LG G   D    T    L+  +    +       HS  LT SG +F WG 
Sbjct: 159  FCWGQNKYGQLGLGT--DCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216

Query: 4109 GDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGL 4168
              +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G +FTFG G YG+LG 
Sbjct: 217  NKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276

Query: 4169 GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 4228
             +TS++  P +V  L G  + ++ACG  HT A       +++FG G  G+LG G+++ + 
Sbjct: 277  NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336

Query: 4229 SP 4230
            SP
Sbjct: 337  SP 338



 Score =  137 bits (344), Expect = 3e-31
 Identities = 99/349 (28%), Positives = 175/349 (50%), Gaps = 20/349 (5%)

Query: 377 WGSNSSHQLVEG--TQEKILQPKLAPSFSDAQTIEAG---QYCTFVISTDGSVRACGKGS 431
           WG+ S  QL  G   +E +L+P+ +  F + +  + G   ++  FV+  DG+V  CG   
Sbjct: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLD-DGTVYTCGCND 62

Query: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491
            G+LG     ++ + KK         + + +    + HTLA   +G+V++WG    G+LG
Sbjct: 63  LGQLG-----HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117

Query: 492 -HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHG-DSN 549
             G+    + P+ I+  L    +V V+ GY HS A+++  E++ WG+  +G+LG G D  
Sbjct: 118 LVGSEECIRVPRNIKS-LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCK 176

Query: 550 SRNIPTLVKDISNVG--EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKV 607
            +  P L+K +  +   +V+ G +H+  L+  G  ++ +G    G+LG  D N  Y P +
Sbjct: 177 KQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSG-AIFGWGRNKFGQLGLNDENDRYVPNL 235

Query: 608 IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLIEELAATR 666
           +++L+   I  +C G   + ALT  G V+ +G G     G +S +  + P+ + EL  + 
Sbjct: 236 LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 667 IVDVSIGDSHCLA-LSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSG 714
           + +++ G  H  A +     +Y++G    GQ G G ST     P  V G
Sbjct: 296 VTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG-STSNRKSPFTVKG 343



 Score =  133 bits (335), Expect = 4e-30
 Identities = 91/284 (32%), Positives = 143/284 (50%), Gaps = 14/284 (4%)

Query: 374 VYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYG 433
           VY  G N   QL      K  +  +A    +   +  G+  T  ++  G V A G  S G
Sbjct: 55  VYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDG 114

Query: 434 RLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG--HTLAFTTEGEVFSWGDGDYGKLG 491
           +LGL  S     + +      +S+  +   + + G  H+LA +   EVF WG   YG+LG
Sbjct: 115 QLGLVGSEECIRVPRNI----KSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170

Query: 492 HG-NSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNS 550
            G +   Q  P+L++  L G   + V+AG  HS  +T  G ++ WG   FG+LG  D N 
Sbjct: 171 LGTDCKKQTSPQLLKS-LLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229

Query: 551 RNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVI 608
           R +P L+K +    +  + CG  HT AL+K+G  V++FG G  G+LGH  T+    P+ +
Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTKEG-GVFTFGAGGYGQLGHNSTSHEINPRKV 288

Query: 609 EALQGMFIRKVCAGSQ-SSLALTSTGQVYAWGCG--ACLGCGSS 649
             L G  + ++  G Q +S  + S+G++Y++G G    LG GS+
Sbjct: 289 FELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST 332



 Score =  127 bits (320), Expect = 2e-28
 Identities = 78/246 (31%), Positives = 126/246 (51%), Gaps = 16/246 (6%)

Query: 373 EVYVWGSNSSHQL-VEGTQEKILQPKLAPSFSDAQTIEA--GQYCTFVISTDGSVRACGK 429
           +VY WG +S  QL + G++E I  P+   S SD Q ++   G Y +  +S    V   G+
Sbjct: 104 QVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQ 163

Query: 430 GSYGRLGLGDSNNQST----LKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDG 485
             YG+LGLG    + T    LK L   P   +           H+   T  G +F WG  
Sbjct: 164 NKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVA------AGGAHSFVLTLSGAIFGWGRN 217

Query: 486 DYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGH 545
            +G+LG  + + +  P L++  L+ + +V +  G  H+AA+T++G ++T+G G +G+LGH
Sbjct: 218 KFGQLGLNDENDRYVPNLLKS-LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276

Query: 546 GDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVY 603
             ++    P  V ++  S V E++CG  HT A       ++SFG G NG+LG G T+   
Sbjct: 277 NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336

Query: 604 KPKVIE 609
            P  ++
Sbjct: 337 SPFTVK 342



 Score =  119 bits (299), Expect = 6e-26
 Identities = 80/261 (30%), Positives = 124/261 (47%), Gaps = 14/261 (5%)

Query: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQG-----KVVVCVSAGYRHSAAVTEDGELYTWG 536
           WG+  +G+LG G    +    ++  P +      K V  V  G RH+  V +DG +YT G
Sbjct: 4   WGNASFGQLGLGGIDEE----IVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCG 59

Query: 537 EGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLG- 595
             D G+LGH  S  +    +  D  N+  VSCG +HT+AL+  G+ V+++G   +G+LG 
Sbjct: 60  CNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQ-VYAWGLDSDGQLGL 118

Query: 596 HGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCG--ACLGCGSSEATA 653
            G    +  P+ I++L  + I +V  G   SLAL+   +V+ WG      LG G+     
Sbjct: 119 VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQ 178

Query: 654 LRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVS 713
             P+L++ L     + V+ G +H   L+    ++ WG N  GQ G  N       P  + 
Sbjct: 179 TSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-NDENDRYVPNLLK 237

Query: 714 GLDGIAIQQISAGTSHSLAWT 734
            L    I  I  G  H+ A T
Sbjct: 238 SLRSQKIVYICCGEDHTAALT 258



 Score =  114 bits (285), Expect = 2e-24
 Identities = 71/225 (31%), Positives = 119/225 (52%), Gaps = 10/225 (4%)

Query: 3958 VPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAG--R 4015
            V  +E + +  N K ++  D QI+  A        L    +V+ WG  ++GQL      +
Sbjct: 119  VGSEECIRVPRNIKSLS--DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCK 176

Query: 4016 NVMVPAAAPSF--SQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVI 4073
                P    S       QV  G   +FV+  +G +   G   +G+LG  + +D +V  ++
Sbjct: 177  KQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLL 236

Query: 4074 SALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQG 4133
             +L+     ++V  C  + H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G
Sbjct: 237  KSLRS---QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMG 293

Query: 4134 EEVVQMSCGFKH-SAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLP 4177
              V +++CG +H SA V S G++++FG G  G+LG G+TSN+K P
Sbjct: 294  SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338



 Score =  103 bits (257), Expect = 4e-21
 Identities = 72/198 (36%), Positives = 108/198 (54%), Gaps = 14/198 (7%)

Query: 368 VSETCEVYVWGSNSSHQLVEGTQ-EKILQPKLAPSFSDA--QTIEAGQYCTFVISTDGSV 424
           +S+  EV+ WG N   QL  GT  +K   P+L  S        + AG   +FV++  G++
Sbjct: 152 LSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAI 211

Query: 425 RACGKGSYGRLGLGDSNNQ---STLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481
              G+  +G+LGL D N++   + LK L     RS K V    G D HT A T EG VF+
Sbjct: 212 FGWGRNKFGQLGLNDENDRYVPNLLKSL-----RSQKIVYICCGED-HTAALTKEGGVFT 265

Query: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRH-SAAVTEDGELYTWGEGDF 540
           +G G YG+LGH ++S +  P+ +   L G +V  ++ G +H SA V   G +Y++G G  
Sbjct: 266 FGAGGYGQLGHNSTSHEINPRKV-FELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGN 324

Query: 541 GRLGHGDSNSRNIPTLVK 558
           G+LG G +++R  P  VK
Sbjct: 325 GQLGTGSTSNRKSPFTVK 342



 Score = 82.8 bits (203), Expect = 8e-15
 Identities = 83/329 (25%), Positives = 147/329 (44%), Gaps = 22/329 (6%)

Query: 4513 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 4571
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 739  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 789

Query: 4572 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNS 4631
             D  L  F  +G++ G+AI     +DLH    ++K+L     +L+DL+E+     +++  
Sbjct: 790  EDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQ 847

Query: 4632 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 4689
            +L   +  I EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 848  LLDYPEDDI-EETFCLNFTITVENF----GATEVKELVLNGADTAVNKQNRQEFVDAYVD 902

Query: 4690 YRLHEMDRQV-AAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 4747
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 903  YIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 962

Query: 4748 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 4807
              +H  ++ FW    E   E++  F+ F++G  R+P      S +  I       + LP 
Sbjct: 963  WAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLKLVIQSTGGGEEYLPV 1021

Query: 4808 SQTCFFQLRLPPYSSQLVMAERLRYAINN 4836
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 1022 SHTCFNLLDLPKYTEKETLRSKLIQAIDH 1050


>gi|4557445 regulator of chromosome condensation and BTB domain
            containing protein 2 [Homo sapiens]
          Length = 551

 Score =  153 bits (386), Expect = 5e-36
 Identities = 98/289 (33%), Positives = 148/289 (51%), Gaps = 6/289 (2%)

Query: 4045 NGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 4104
            N  +   G    G LG G+         + +L G  +  L  S GS  H +  T  GEVF
Sbjct: 64   NDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACL--SYGSGPHIVLATTEGEVF 121

Query: 4105 SWGDGDYGKLGHGNSDRQRRPRQIEA-LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 4163
            +WG   Y +LG+G ++    P  I   L  ++V++++CG  HS V+TSDG++F +G  + 
Sbjct: 122  TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181

Query: 4164 GRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 4222
            G++G G+T N+ +P RVT  L+   +  +ACG    +AV  D   V+ +G    G+LGLG
Sbjct: 182  GQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAV-VDTGEVYVWGYNGNGQLGLG 240

Query: 4223 NSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRP 4282
            NS  + +P ++  L GI +++VACG   ++ LT +G VY +G +    L  G   N + P
Sbjct: 241  NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYP 300

Query: 4283 QQIPVLAGVIIEDVAVGAEHT-LALASNGDVYAWGSNSEGQLGLGHTNH 4330
              + V    IIE  A  + HT  A    G VY WG      + L H  H
Sbjct: 301  TPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPHLTH 349



 Score =  145 bits (366), Expect = 1e-33
 Identities = 92/276 (33%), Positives = 156/276 (56%), Gaps = 8/276 (2%)

Query: 4089 GSDGHSMALTE-SGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF-KHS 4146
            GS G+ +  T  + E+F  G    G LG G+      PR++++L G+++  +S G   H 
Sbjct: 52   GSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHI 111

Query: 4147 AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGYQIGQVACGLNHTLAVSADG 4205
             + T++G++FT+G+  Y +LG G T++  +P  + T L   Q+ +VACG  H+L +++DG
Sbjct: 112  VLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDG 171

Query: 4206 SMVWAFGDGDYGKLGLGNSTAKSSPQKID-VLCGIGIKKVACGTQFSVALTKDGHVYTFG 4264
              V+A+G  + G++G G++  +  P+++   L    +  +ACG    +A+   G VY +G
Sbjct: 172  E-VFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230

Query: 4265 QDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLG 4324
             +    L  G + N   P ++  L G+ ++ VA G  HTL L   G VYAWG+NS GQLG
Sbjct: 231  YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290

Query: 4325 LGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTA 4360
             G+ ++   PT VT ++   + +I+A  CHS   +A
Sbjct: 291  TGNKSNQSYPTPVT-VEKDRIIEIAA--CHSTHTSA 323



 Score =  133 bits (334), Expect = 5e-30
 Identities = 88/259 (33%), Positives = 137/259 (52%), Gaps = 16/259 (6%)

Query: 465 GSDGHTLAFTT-EGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYR-H 522
           GS G+ + +TT   E+F  G    G LG G+  +   P+ +   L GK + C+S G   H
Sbjct: 52  GSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDS-LNGKKIACLSYGSGPH 110

Query: 523 SAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVK-DISN--VGEVSCGSSHTIALSKD 579
               T +GE++TWG   + +LG+G +N   +P  +  ++SN  V EV+CGS H++ L+ D
Sbjct: 111 IVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSD 170

Query: 580 GRTVWSFGGGDNGKLGHGDT-NRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638
           G  V+++G  ++G++G G T N+    +V   LQ   +  +  G    +A+  TG+VY W
Sbjct: 171 GE-VFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVW 229

Query: 639 GCGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQ 696
           G      LG G+S      P  +  L   R+  V+ G +H L L+ + +VYAWG NS GQ
Sbjct: 230 GYNGNGQLGLGNS-GNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQ 288

Query: 697 CGQGNSTG-----PITKPK 710
            G GN +      P+T  K
Sbjct: 289 LGTGNKSNQSYPTPVTVEK 307



 Score =  133 bits (334), Expect = 5e-30
 Identities = 93/272 (34%), Positives = 137/272 (50%), Gaps = 16/272 (5%)

Query: 428 GKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDY 487
           G    G LGLGD   QST++    +     K    S GS  H +  TTEGEVF+WG   Y
Sbjct: 71  GTNCCGCLGLGDV--QSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAY 128

Query: 488 GKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGD 547
            +LG+G ++    P  I   L  K V+ V+ G  HS  +T DGE++ WG  + G++G G 
Sbjct: 129 SQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGS 188

Query: 548 SNSRNIPTLVKDISN---VGEVSCGSSHTIALSKDGRT-VWSFGGGDNGKLGHGDTNRVY 603
           + ++ IP  V        V  ++CG    +A+   G   VW + G  NG+LG G++    
Sbjct: 189 TVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNG--NGQLGLGNSGNQP 246

Query: 604 KPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGAC--LGCGS-SEATALRPKLIE 660
            P  + ALQG+ +++V  G   +L LT  GQVYAWG  +   LG G+ S  +   P  +E
Sbjct: 247 TPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVE 306

Query: 661 ELAATRIVDVSIGDS--HCLALSHDNEVYAWG 690
           +    RI++++   S     A +    VY WG
Sbjct: 307 K---DRIIEIAACHSTHTSAAKTQGGHVYMWG 335



 Score =  129 bits (324), Expect = 7e-29
 Identities = 85/273 (31%), Positives = 140/273 (51%), Gaps = 9/273 (3%)

Query: 373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT--IEAGQYCTFVIST-DGSVRACGK 429
           E++V G+N    L  G  +  ++P+   S +  +   +  G     V++T +G V   G 
Sbjct: 66  EIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 125

Query: 430 GSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGK 489
            +Y +LG G +N+   L       + S K+V        H+L  T++GEVF+WG  + G+
Sbjct: 126 NAYSQLGNGTTNH--GLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQ 183

Query: 490 LGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSN 549
           +G G++  Q  P+ + G LQ KVVV ++ G     AV + GE+Y WG    G+LG G+S 
Sbjct: 184 VGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG 243

Query: 550 SRNIPTLVKDIS--NVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGD-TNRVYKPK 606
           ++  P  V  +    V  V+CG +HT+ L+ +G+ V+++G    G+LG G+ +N+ Y   
Sbjct: 244 NQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQ-VYAWGANSYGQLGTGNKSNQSYPTP 302

Query: 607 VIEALQGMFIRKVCAGSQSSLALTSTGQVYAWG 639
           V      +     C  + +S A T  G VY WG
Sbjct: 303 VTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335



 Score =  120 bits (302), Expect = 3e-26
 Identities = 75/220 (34%), Positives = 117/220 (53%), Gaps = 8/220 (3%)

Query: 3998 DVYLWGAGRHGQLAEAGRNV-MVPAAAPSFSQAQQVI---CGQNCTFVIQANGTVLACGE 4053
            +V+ WG   + QL     N  +VP    +    +QVI   CG   + V+ ++G V A G 
Sbjct: 119  EVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY 178

Query: 4054 GSYGRLGQGNSDDLHV-LTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 4112
             + G++G G++ +  +   V   LQ  VV  +  +CG     MA+ ++GEV+ WG    G
Sbjct: 179  NNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTI--ACGQMC-CMAVVDTGEVYVWGYNGNG 235

Query: 4113 KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 4172
            +LG GNS  Q  P ++ ALQG  V +++CG+ H+ V+T +G+++ +G   YG+LG GN S
Sbjct: 236  QLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKS 295

Query: 4173 NKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212
            N+  P  VT  +   I   AC   HT A    G  V+ +G
Sbjct: 296  NQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335



 Score = 92.0 bits (227), Expect = 1e-17
 Identities = 54/174 (31%), Positives = 82/174 (47%), Gaps = 6/174 (3%)

Query: 367 IVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQ---TIEAGQYCTFVISTDGS 423
           +++   EV+ WG N+S Q+  G+      P+        +   TI  GQ C   +   G 
Sbjct: 166 VLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGE 225

Query: 424 VRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWG 483
           V   G    G+LGLG+S NQ T  ++       +++V+       HTL  T EG+V++WG
Sbjct: 226 VYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGY---AHTLVLTDEGQVYAWG 282

Query: 484 DGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGE 537
              YG+LG GN S Q YP  +       + +        SAA T+ G +Y WG+
Sbjct: 283 ANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 43/127 (33%), Positives = 71/127 (55%), Gaps = 6/127 (4%)

Query: 592 GKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTST-GQVYAWGCGAC--LGCGS 648
           G LG GD     +P+ +++L G  I  +  GS   + L +T G+V+ WG  A   LG G+
Sbjct: 76  GCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGT 135

Query: 649 SEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTG-PIT 707
           +    +   +   L+  ++++V+ G  H L L+ D EV+AWG N+ GQ G G++   PI 
Sbjct: 136 TNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPI- 194

Query: 708 KPKKVSG 714
            P++V+G
Sbjct: 195 -PRRVTG 200



 Score = 57.0 bits (136), Expect = 4e-07
 Identities = 38/136 (27%), Positives = 68/136 (50%), Gaps = 10/136 (7%)

Query: 616 IRKVCA-GSQSSLALTST--GQVYAWG--CGACLGCGSSEATALRPKLIEELAATRIVDV 670
           IR+ C  GS  +  L +T   +++  G  C  CLG G  ++T + P+ ++ L   +I  +
Sbjct: 45  IRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQST-IEPRRLDSLNGKKIACL 103

Query: 671 SIGDS-HCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSH 729
           S G   H +  + + EV+ WG+N+  Q G G +   +      + L    + +++ G+ H
Sbjct: 104 SYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYH 163

Query: 730 SLAWTALPRDRQVVAW 745
           SL  T+   D +V AW
Sbjct: 164 SLVLTS---DGEVFAW 176


>gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens]
          Length = 3996

 Score =  151 bits (381), Expect = 2e-35
 Identities = 135/504 (26%), Positives = 223/504 (44%), Gaps = 59/504 (11%)

Query: 4380 DTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLL---NLSPNNQNSTSHYNAGTW 4436
            D   P+   L  V I ++R R  LL   +  + + +  L     +P   +S +       
Sbjct: 3496 DAADPRVACLLNVPIESLRLRFALLQSLNTTLETFFLPLVELRQTPMYTHSIAALLKEAK 3555

Query: 4437 GIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKP----IFVQ 4492
            G++    +  +  RV    + R+         +  P+IT+  +   G + +      F Q
Sbjct: 3556 GLIFYDTKVTVMNRVLNATVQRT-------ADHAAPEITLDPLEIVGGEIRASENSYFCQ 3608

Query: 4493 IARQVVKLNASDLRL-------PSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVD 4545
             ARQ+  + +S L +       P+ A+ ++  GE      G F   + ++C+EL++  + 
Sbjct: 3609 AARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLS 3668

Query: 4546 LLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVW 4605
            LL+  P++   V  N+ +++  PS           FLG L+G+AIR   PL L L P  W
Sbjct: 3669 LLLLCPSSA--VNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFW 3726

Query: 4606 KQLCCVPLTLE-DLEEVDLLYVQTLNSILHIEDSGITEESFHEMI--------------P 4650
            K L   PL  E DL+E D+L    +     I D    E    E+               P
Sbjct: 3727 KTLVGEPLDPEQDLQEADILTYNYVKKFESINDETELEALCAEIASQHLATESPDSPNKP 3786

Query: 4651 LDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQ--VAAVREGMSW 4708
               F   +  G+ V +   G  I + + N+  Y       RL E+     V AVR G+  
Sbjct: 3787 CCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAVRAGLGS 3846

Query: 4709 IVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EVDEQHQLVQWFWHTLEEFSNE 4767
            I+P+ LL++L+  ++E   CG+P I++E LK    Y+  + E  Q +++FW  LE F+ E
Sbjct: 3847 IIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQE 3906

Query: 4768 ERVLFMRFVSGRSRLP---------ANTADISQRFQIMKVDRPYDSL--PTS-----QTC 4811
            E   F++F   + R+P          +TA +      MK+  P  +   P S     +TC
Sbjct: 3907 ELCKFIKFACNQERIPFTCPCKDGGPDTAHVPP--YPMKIAPPDGTAGSPDSRYIRVETC 3964

Query: 4812 FFQLRLPPYSSQLVMAERLRYAIN 4835
             F ++LP YSS  +M E+LR AI+
Sbjct: 3965 MFMIKLPQYSSLEIMLEKLRCAIH 3988


>gi|61563742 hect domain and RLD 6 [Homo sapiens]
          Length = 1022

 Score =  150 bits (378), Expect = 4e-35
 Identities = 110/391 (28%), Positives = 190/391 (48%), Gaps = 18/391 (4%)

Query: 4031 QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS 4090
            Q   G+  + ++  N  VL+CG+ S G+LG+  +    +   I AL+  +V   + SCG 
Sbjct: 27   QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVD--LVSCGK 84

Query: 4091 DGHSMALTESGEVFSWGDGDYGKLGHGN-SDRQRRPRQIEALQGEEVVQMSCGFKHSAVV 4149
            + HS+A+   G VF+WG G  G+LG G   +    P++I  L   +++Q+SCG  HS  +
Sbjct: 85   E-HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLAL 143

Query: 4150 TSDGKLFTFGNGDYGRLGLGNT-SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMV 4208
            + D ++F++G   +G+LGLG    ++  P+RV +LEG  + QVA G  H+ A+S  G+  
Sbjct: 144  SKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTS- 202

Query: 4209 WAFGDGDYGKLGLGNSTA---KSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQ 4265
            + +G    G+L L         + P  +  L  +G+  ++CG   +  LT+DG V+TFG 
Sbjct: 203  FGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGD 262

Query: 4266 DRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLA-LASNGDVYAWGSNSEGQLG 4324
            +R   L          PQ +  + G ++  +  G+ HTLA + + G V ++G        
Sbjct: 263  NRSGQLGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSK 321

Query: 4325 LGHTNHVREPTLVTGLQGK------NVRQISAGRCHSAAWTAPPV-PPRAPGVSVPLQLG 4377
              H   + E   ++ L          V+ I AG   +   T       RAPG ++P    
Sbjct: 322  PTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPGKTLPEISR 381

Query: 4378 LPDTVPPQYGALREVSIHTVRARLRLLYHFS 4408
            +  ++  ++ A++  S     A+  +   FS
Sbjct: 382  ISQSMAEKWIAVKRRSTEHEMAKSEIRMIFS 412



 Score =  143 bits (360), Expect = 5e-33
 Identities = 95/281 (33%), Positives = 147/281 (52%), Gaps = 7/281 (2%)

Query: 4083 QLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCG 4142
            +L+ +   + HS+ L  +  V S GD   G+LG   + R   P  I+AL+   V  +SCG
Sbjct: 24   ELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCG 83

Query: 4143 FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKL-PERVTALEGYQIGQVACGLNHTLAV 4201
             +HS  V   G++F +G G  G+LG+G        P+++  L   +I QV+CG  H+LA+
Sbjct: 84   KEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLAL 143

Query: 4202 SADGSMVWAFGDGDYGKLGLGNS-TAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHV 4260
            S D S V+++G   +G+LGLG    +++SPQ++  L GI + +VA G   S AL+  G  
Sbjct: 144  SKD-SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTS 202

Query: 4261 YTFGQDRLIGLP-EGR--ARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGS 4317
            + +G +    L   GR      N+P  +  L  + +  ++ G  HT  L  +G V+ +G 
Sbjct: 203  FGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGD 262

Query: 4318 NSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAW 4358
            N  GQLG   T   R P LV  + G  V QI  G  H+ A+
Sbjct: 263  NRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAY 302



 Score =  130 bits (326), Expect = 4e-29
 Identities = 91/275 (33%), Positives = 143/275 (52%), Gaps = 16/275 (5%)

Query: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTE 528
           H+L   T   V S GD   G+LG   +   + P+ IQ  L+  +V  VS G  HS AV  
Sbjct: 34  HSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQA-LETLIVDLVSCGKEHSLAVCH 92

Query: 529 DGELYTWGEGDFGRLGHGDSNS-----RNIPTLVKDISNVGEVSCGSSHTIALSKDGRTV 583
            G ++ WG G  G+LG G+        + I TL  DI  + +VSCG  H++ALSKD + V
Sbjct: 93  KGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTL-NDIKII-QVSCGHYHSLALSKDSQ-V 149

Query: 584 WSFGGGDNGKLGHG-DTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGA 642
           +S+G   +G+LG G +      P+ + +L+G+ + +V AG   S AL+  G  + WG  +
Sbjct: 150 FSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNS 209

Query: 643 ----CLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCG 698
                L   +    + +P  +  L    +V +S GD+H   L+ D +V+ +G+N  GQ G
Sbjct: 210 AGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLG 269

Query: 699 QGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAW 733
             + T     P+ V  +DG+ + QI  G+ H+LA+
Sbjct: 270 Y-SPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAY 302



 Score =  129 bits (325), Expect = 5e-29
 Identities = 85/248 (34%), Positives = 133/248 (53%), Gaps = 6/248 (2%)

Query: 4117 GNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKL 4176
            G   R+ + R+     G E++Q + G +HS ++ ++ ++ + G+   G+LG       +L
Sbjct: 6    GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65

Query: 4177 PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS-SPQKIDV 4235
            PE + ALE   +  V+CG  H+LAV   G  V+A+G G  G+LG+G     S +P+KI  
Sbjct: 66   PEPIQALETLIVDLVSCGKEHSLAVCHKG-RVFAWGAGSEGQLGIGEFKEISFTPKKIMT 124

Query: 4236 LCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIPVLAGVIIE 4294
            L  I I +V+CG   S+AL+KD  V+++G++    L  G+   +   PQ++  L G+ + 
Sbjct: 125  LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLA 184

Query: 4295 DVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTN---HVREPTLVTGLQGKNVRQISAG 4351
             VA G  H+ AL+  G  + WGSNS GQL L   N      +P  V  L+   V  IS G
Sbjct: 185  QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG 244

Query: 4352 RCHSAAWT 4359
              H+A  T
Sbjct: 245  DAHTAVLT 252



 Score =  114 bits (285), Expect = 2e-24
 Identities = 109/376 (28%), Positives = 182/376 (48%), Gaps = 41/376 (10%)

Query: 378 GSNSSHQLVE-GTQE-KILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRL 435
           G NS  QL   G Q  ++ +P  A        +  G+  +  +   G V A G GS G+L
Sbjct: 48  GDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQL 107

Query: 436 GLGDSNNQSTLKKLTFEPHR-----SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKL 490
           G+G+       K+++F P +      IK +  S G   H+LA + + +VFSWG   +G+L
Sbjct: 108 GIGE------FKEISFTPKKIMTLNDIKIIQVSCGHY-HSLALSKDSQVFSWGKNSHGQL 160

Query: 491 GHGNS-STQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSN 549
           G G    +Q  P+ ++  L+G  +  V+AG  HS A++  G  + WG    G+L     N
Sbjct: 161 GLGKEFPSQASPQRVRS-LEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRN 219

Query: 550 ---SRNIPTLVKDISNVGEV--SCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYK 604
                N P  V  + N+G V  SCG +HT  L++DG+ V++FG   +G+LG+  T     
Sbjct: 220 VPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGK-VFTFGDNRSGQLGYSPTPEKRG 278

Query: 605 PKVIEALQGMFIRKVCAGSQSSLALT-STGQVYAWGCGACLGCGSSEATALRPKLIEE-- 661
           P+++E + G+ + ++  GS  +LA   +TGQV ++G G      S  +    P+ + E  
Sbjct: 279 PQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFGHGP-----SDTSKPTHPEALTENF 332

Query: 662 -----LAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLD 716
                ++A   VDV +   H  A ++ N V    + S  +   G +   I++  +     
Sbjct: 333 DISCLISAEDFVDVQV--KHIFAGTYANFVTTHQDTSSTR-APGKTLPEISRISQSMAEK 389

Query: 717 GIAIQQISAGTSHSLA 732
            IA+++ S  T H +A
Sbjct: 390 WIAVKRRS--TEHEMA 403



 Score =  111 bits (278), Expect = 2e-23
 Identities = 63/170 (37%), Positives = 94/170 (55%), Gaps = 3/170 (1%)

Query: 565 EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQ 624
           + + G  H++ L  + R V S G    G+LG     R   P+ I+AL+ + +  V  G +
Sbjct: 27  QAASGERHSLLLLTNHR-VLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKE 85

Query: 625 SSLALTSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSH 682
            SLA+   G+V+AWG G+   LG G  +  +  PK I  L   +I+ VS G  H LALS 
Sbjct: 86  HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSK 145

Query: 683 DNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732
           D++V++WG NS GQ G G        P++V  L+GI + Q++AG +HS A
Sbjct: 146 DSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA 195



 Score =  109 bits (272), Expect = 8e-23
 Identities = 73/224 (32%), Positives = 108/224 (48%), Gaps = 12/224 (5%)

Query: 3999 VYLWGAGRHGQL--AEAGRNVMVPAAAPSFSQAQ--QVICGQNCTFVIQANGTVLACGEG 4054
            V+ WGAG  GQL   E       P    + +  +  QV CG   +  +  +  V + G+ 
Sbjct: 96   VFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKN 155

Query: 4055 SYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGK 4113
            S+G+LG G           + +L+G  + Q+        HS AL+  G  F WG    G+
Sbjct: 156  SHGQLGLGKEFPSQASPQRVRSLEGIPLAQV---AAGGAHSFALSLCGTSFGWGSNSAGQ 212

Query: 4114 L---GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 4170
            L   G     +  +P  + AL+   VV +SCG  H+AV+T DGK+FTFG+   G+LG   
Sbjct: 213  LALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSP 272

Query: 4171 TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDG 4214
            T  K+ P+ V  ++G  + Q+ CG  HTLA       V +FG G
Sbjct: 273  TPEKRGPQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFGHG 315



 Score =  106 bits (264), Expect = 6e-22
 Identities = 68/232 (29%), Positives = 112/232 (48%), Gaps = 8/232 (3%)

Query: 510 GKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--VGEVS 567
           G  ++  ++G RHS  +  +  + + G+   G+LG   +    +P  ++ +    V  VS
Sbjct: 22  GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81

Query: 568 CGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRV-YKPKVIEALQGMFIRKVCAGSQSS 626
           CG  H++A+   GR V+++G G  G+LG G+   + + PK I  L  + I +V  G   S
Sbjct: 82  CGKEHSLAVCHKGR-VFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHS 140

Query: 627 LALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDN 684
           LAL+   QV++WG  +   LG G    +   P+ +  L    +  V+ G +H  ALS   
Sbjct: 141 LALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCG 200

Query: 685 EVYAWGNNSMGQCGQGNSTGPI--TKPKKVSGLDGIAIQQISAGTSHSLAWT 734
             + WG+NS GQ        P+   KP  V  L  + +  IS G +H+   T
Sbjct: 201 TSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLT 252



 Score =  103 bits (256), Expect = 5e-21
 Identities = 75/244 (30%), Positives = 127/244 (52%), Gaps = 20/244 (8%)

Query: 374 VYVWGSNSSHQLVEGTQEKI-LQPKLAPSFSDAQTIEA--GQYCTFVISTDGSVRACGKG 430
           V+ WG+ S  QL  G  ++I   PK   + +D + I+   G Y +  +S D  V + GK 
Sbjct: 96  VFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKN 155

Query: 431 SYGRLGLG-DSNNQSTLKKLTFEPHRSIKKVSSSKGSDG--HTLAFTTEGEVFSWGDGDY 487
           S+G+LGLG +  +Q++ +++     RS++ +  ++ + G  H+ A +  G  F WG    
Sbjct: 156 SHGQLGLGKEFPSQASPQRV-----RSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210

Query: 488 GKLGHG--NSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGH 545
           G+L     N   Q    L  G L+   VV +S G  H+A +T+DG+++T+G+   G+LG+
Sbjct: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270

Query: 546 GDSNSRNIPTLVKDISN-VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYK 604
             +  +  P LV+ I   V ++ CGS HT+A       V SFG G +      DT++   
Sbjct: 271 SPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHGPS------DTSKPTH 324

Query: 605 PKVI 608
           P+ +
Sbjct: 325 PEAL 328



 Score =  101 bits (252), Expect = 2e-20
 Identities = 88/317 (27%), Positives = 150/317 (47%), Gaps = 21/317 (6%)

Query: 388 GTQEKILQPKLAPSFSDAQTIEA--GQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQST 445
           G   + LQ +       A+ ++A  G+  + ++ T+  V +CG  S G+LG   +     
Sbjct: 6   GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65

Query: 446 LKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKY-PKLI 504
            + +       +  VS  K    H+LA   +G VF+WG G  G+LG G      + PK I
Sbjct: 66  PEPIQALETLIVDLVSCGK---EHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKI 122

Query: 505 QGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHG-DSNSRNIPTLVKDISNV 563
              L    ++ VS G+ HS A+++D ++++WG+   G+LG G +  S+  P  V+ +  +
Sbjct: 123 M-TLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGI 181

Query: 564 --GEVSCGSSHTIALSKDGRTVWSFGGGDN--GKLGHGDTN---RVYKPKVIEALQGMFI 616
              +V+ G +H+ ALS  G    SFG G N  G+L     N   +  KP  + AL+ + +
Sbjct: 182 PLAQVAAGGAHSFALSLCGT---SFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGV 238

Query: 617 RKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALR-PKLIEELAATRIVDVSIGDS 675
             +  G   +  LT  G+V+ +G       G S     R P+L+E +    +  +  G  
Sbjct: 239 VYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSY 297

Query: 676 HCLALSH-DNEVYAWGN 691
           H LA  H   +V ++G+
Sbjct: 298 HTLAYVHTTGQVVSFGH 314



 Score = 73.9 bits (180), Expect = 4e-12
 Identities = 84/353 (23%), Positives = 153/353 (43%), Gaps = 36/353 (10%)

Query: 4495 RQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNAT 4554
            RQ+ +  A+D     +   V+ + E   ++GGV  +    M +E+      + +      
Sbjct: 687  RQLSQAEATDF---CKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFM-----Y 738

Query: 4555 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLT 4614
             E+G      ++ P+    E    F F G+L G+++      +L     ++K+L     +
Sbjct: 739  PEMG----SCMWFPAKPKPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLDQKPS 793

Query: 4615 LEDLEEVDLLYVQTLNSILH-----IEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPG 4669
            LEDL+E+     ++L  +L      I D+     S H             D   V +IP 
Sbjct: 794  LEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHW------------DQNDVDLIPN 841

Query: 4670 GNSIPLTFSNRKEYVERAIEYRLHEMDRQV-AAVREGMSWIVPVPLLSLLTAKQLEQMVC 4728
            G SIP+  +N+++YV + I+Y  +   + V    + G   +    +L     ++L   + 
Sbjct: 842  GISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAII 901

Query: 4729 GMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTA 4787
            G  +   +  ++  +Y +   + H  +Q FW    + + +E+  F+ F++GR RL A   
Sbjct: 902  GNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHAR-- 959

Query: 4788 DISQRFQIMKVDRPYDSL--PTSQTCFFQLRLPPYSSQLVMAERLRYAINNCR 4838
             I +   + +    +     PTS TC   L LP YS+   M E L+ AINN R
Sbjct: 960  GIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNR 1012



 Score = 58.9 bits (141), Expect = 1e-07
 Identities = 56/205 (27%), Positives = 95/205 (46%), Gaps = 15/205 (7%)

Query: 368 VSETCEVYVWGSNSSHQLVEGTQ-EKILQPKLAPSFS--DAQTIEAGQYCTFVISTDGSV 424
           +S+  +V+ WG NS  QL  G +      P+   S        + AG   +F +S  G+ 
Sbjct: 143 LSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTS 202

Query: 425 RACGKGSYGRLGLGDSN-NQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWG 483
              G  S G+L L   N    + K L+    +++  V  S G D HT   T +G+VF++G
Sbjct: 203 FGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG-DAHTAVLTQDGKVFTFG 261

Query: 484 DGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRL 543
           D   G+LG+  +  ++ P+L++  + G +V  +  G  H+ A       Y    G     
Sbjct: 262 DNRSGQLGYSPTPEKRGPQLVE-RIDG-LVSQIDCGSYHTLA-------YVHTTGQVVSF 312

Query: 544 GHGDSNSRNIPTLVKDISNVGEVSC 568
           GHG S++   PT  + ++   ++SC
Sbjct: 313 GHGPSDTSK-PTHPEALTENFDISC 336



 Score = 47.8 bits (112), Expect = 3e-04
 Identities = 46/147 (31%), Positives = 70/147 (47%), Gaps = 22/147 (14%)

Query: 4002 WGAGRHGQLAEAGRNVMVPAAAPSFSQAQQ------VICGQNCTFVIQANGTVLACGEGS 4055
            WG+   GQLA +GRNV V +  P    A +      + CG   T V+  +G V   G+  
Sbjct: 205  WGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNR 264

Query: 4056 YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTE-SGEVFSWGDGDYGKL 4114
             G+LG   + +     ++  + G +V+Q+   CGS  H++A    +G+V S+        
Sbjct: 265  SGQLGYSPTPEKRGPQLVERIDG-LVSQI--DCGS-YHTLAYVHTTGQVVSF-------- 312

Query: 4115 GHGNSDRQRRPRQIEALQGEEVVQMSC 4141
            GHG SD   +P   EAL   E   +SC
Sbjct: 313  GHGPSDTS-KPTHPEAL--TENFDISC 336



 Score = 40.8 bits (94), Expect = 0.033
 Identities = 23/88 (26%), Positives = 44/88 (50%), Gaps = 3/88 (3%)

Query: 646 CGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCG-QGNSTG 704
           C  +++  L+ +         ++  + G+ H L L  ++ V + G+NS GQ G +G   G
Sbjct: 4   CWGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRG 63

Query: 705 PITKPKKVSGLDGIAIQQISAGTSHSLA 732
            +  P+ +  L+ + +  +S G  HSLA
Sbjct: 64  EL--PEPIQALETLIVDLVSCGKEHSLA 89


>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
            sapiens]
          Length = 815

 Score =  149 bits (375), Expect = 9e-35
 Identities = 105/335 (31%), Positives = 173/335 (51%), Gaps = 16/335 (4%)

Query: 4034 CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 4093
            CG   + V+  N  +   G  ++G+LG G+   +   T + AL+   V   + +CG + H
Sbjct: 42   CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVK--LAACGRN-H 98

Query: 4094 SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGE-EVVQMSCGFKHSAVVTSD 4152
            ++  TE G V++ G  + G+LG G+++ +     I     E ++ Q+S G   SA +T D
Sbjct: 99   TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158

Query: 4153 GKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212
            G+LF +G+   G++GL N SN  +P++VT   G  +  ++CG  H+  V+ DG + + FG
Sbjct: 159  GRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGEL-YVFG 215

Query: 4213 DGDYGKLGLGNSTAKS--SPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG 4270
            + + GKLGL N    +  +PQ +  +    I+ VACG + +V LT++  VYTFG  +   
Sbjct: 216  EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQ 273

Query: 4271 LPEGRAR-NHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLG--- 4326
            L  G      + P+ I  +    I  ++ G  HT  +   G +Y +G    G+LGLG   
Sbjct: 274  LGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333

Query: 4327 HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAP 4361
             TNH   PTL +      V+ ++ G CH   + AP
Sbjct: 334  FTNHF-IPTLCSNFLRFIVKLVACGGCHMVVFAAP 367



 Score =  146 bits (369), Expect = 4e-34
 Identities = 106/323 (32%), Positives = 167/323 (51%), Gaps = 17/323 (5%)

Query: 3995 GKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQV---ICGQNCTFVIQANGTVLAC 4051
            G   +Y++G+   GQL    ++ +         + ++V    CG+N T V    G V A 
Sbjct: 52   GNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYAT 111

Query: 4052 GEGSYGRLGQGNSDDLHVLTVISALQG-FVVTQLVTSCGSDGHSMALTESGEVFSWGDGD 4110
            G  + G+LG G++++ +   VIS       + QL  S GS+  S ALTE G +F WGD  
Sbjct: 112  GGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQL--SAGSN-TSAALTEDGRLFMWGDNS 168

Query: 4111 YGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 4170
             G++G  N      P+Q+    G+ V  +SCG+ HSA VT+DG+L+ FG  + G+LGL N
Sbjct: 169  EGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPN 226

Query: 4171 --TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 4228
                N + P+ V+ +   ++ QVACG  HT+ ++ +   V+ FG G +G+LGLG    ++
Sbjct: 227  QLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENA--VYTFGLGQFGQLGLGTFLFET 283

Query: 4229 S-PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDR--LIGLPEGRARNHNRPQQI 4285
            S P+ I+ +    I  ++CG   +  +T  G +YTFG  R   +GL      NH  P   
Sbjct: 284  SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLC 343

Query: 4286 PVLAGVIIEDVAVGAEHTLALAS 4308
                  I++ VA G  H +  A+
Sbjct: 344  SNFLRFIVKLVACGGCHMVVFAA 366



 Score =  143 bits (360), Expect = 5e-33
 Identities = 88/277 (31%), Positives = 150/277 (54%), Gaps = 10/277 (3%)

Query: 4087 SCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHS 4146
            SCG D HS  +T + +++ +G  ++G+LG G+     +P  ++AL+ E+V   +CG  H+
Sbjct: 41   SCG-DEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 4147 AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEG-YQIGQVACGLNHTLAVSADG 4205
             V T  G ++  G  + G+LGLG+T  +     ++     ++I Q++ G N + A++ DG
Sbjct: 100  LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 4206 SMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG- 4264
             + + +GD   G++GL N +    PQ++ +  G  +  ++CG   S  +T DG +Y FG 
Sbjct: 160  RL-FMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGE 216

Query: 4265 -QDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQL 4323
             ++  +GLP     NH  PQ +  +   +I+ VA G EHT+ L  N  VY +G    GQL
Sbjct: 217  PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQL 274

Query: 4324 GLG-HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWT 4359
            GLG       EP ++  ++ + +  IS G  H+A  T
Sbjct: 275  GLGTFLFETSEPKVIENIRDQTISYISCGENHTALIT 311



 Score =  111 bits (278), Expect = 2e-23
 Identities = 89/334 (26%), Positives = 157/334 (47%), Gaps = 13/334 (3%)

Query: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSD 467
           +  G   + V++ +  +   G  ++G+LGLG   ++S + K T       +KV  +    
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG---SKSAISKPTCVKALKPEKVKLAACGR 96

Query: 468 GHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
            HTL  T  G V++ G  + G+LG G++  +    +I        +  +SAG   SAA+T
Sbjct: 97  NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156

Query: 528 EDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFG 587
           EDG L+ WG+   G++G  + ++  +P  V     V  +SCG  H+  ++ DG  ++ FG
Sbjct: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGE-LYVFG 215

Query: 588 GGDNGKLGHGD--TNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCG--AC 643
             +NGKLG  +        P+++  +    I+  C G + ++ LT    VY +G G    
Sbjct: 216 EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVAC-GGEHTVVLTENA-VYTFGLGQFGQ 273

Query: 644 LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQG--N 701
           LG G+       PK+IE +    I  +S G++H   ++    +Y +G+   G+ G G  N
Sbjct: 274 LGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333

Query: 702 STGPITKPKKVSGLDGIAIQQISAGTSHSLAWTA 735
            T     P   S      ++ ++ G  H + + A
Sbjct: 334 FTNHFI-PTLCSNFLRFIVKLVACGGCHMVVFAA 366



 Score = 90.9 bits (224), Expect = 3e-17
 Identities = 70/228 (30%), Positives = 117/228 (51%), Gaps = 9/228 (3%)

Query: 512 VVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCG 569
           V V +S G  HSA VT + +LY +G  ++G+LG G  ++ + PT VK +    V   +CG
Sbjct: 36  VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95

Query: 570 SSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMF-IRKVCAGSQSSLA 628
            +HT+ +S +G  V++ GG + G+LG GDT       VI        I+++ AGS +S A
Sbjct: 96  RNHTL-VSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154

Query: 629 LTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVD-VSIGDSHCLALSHDNEVY 687
           LT  G+++ WG  +    G    + +   + +++   + V  +S G  H   ++ D E+Y
Sbjct: 155 LTEDGRLFMWGDNSEGQIGLKNVSNV--CVPQQVTIGKPVSWISCGYYHSAFVTTDGELY 212

Query: 688 AWGNNSMGQCGQGNS-TGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
            +G    G+ G  N   G    P+ VS +    I Q++ G  H++  T
Sbjct: 213 VFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLT 259



 Score = 87.4 bits (215), Expect = 3e-16
 Identities = 63/223 (28%), Positives = 109/223 (48%), Gaps = 13/223 (5%)

Query: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRAC 427
           ++E   +++WG NS  Q+       +  P+          I  G Y +  ++TDG +   
Sbjct: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVF 214

Query: 428 GKGSYGRLGLGDS--NNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDG 485
           G+   G+LGL +    N  T + ++  P + I+     +    HT+  T E  V+++G G
Sbjct: 215 GEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGE----HTVVLT-ENAVYTFGLG 269

Query: 486 DYGKLGHGNSSTQ-KYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544
            +G+LG G    +   PK+I+  ++ + +  +S G  H+A +T+ G +YT+G+G  G+LG
Sbjct: 270 QFGQLGLGTFLFETSEPKVIEN-IRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328

Query: 545 HGDSNSRN--IPTLVKDISN--VGEVSCGSSHTIALSKDGRTV 583
            G  N  N  IPTL  +     V  V+CG  H +  +   R V
Sbjct: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGV 371


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score =  149 bits (375), Expect = 9e-35
 Identities = 105/335 (31%), Positives = 173/335 (51%), Gaps = 16/335 (4%)

Query: 4034 CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 4093
            CG   + V+  N  +   G  ++G+LG G+   +   T + AL+   V   + +CG + H
Sbjct: 42   CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVK--LAACGRN-H 98

Query: 4094 SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGE-EVVQMSCGFKHSAVVTSD 4152
            ++  TE G V++ G  + G+LG G+++ +     I     E ++ Q+S G   SA +T D
Sbjct: 99   TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158

Query: 4153 GKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212
            G+LF +G+   G++GL N SN  +P++VT   G  +  ++CG  H+  V+ DG + + FG
Sbjct: 159  GRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGEL-YVFG 215

Query: 4213 DGDYGKLGLGNSTAKS--SPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG 4270
            + + GKLGL N    +  +PQ +  +    I+ VACG + +V LT++  VYTFG  +   
Sbjct: 216  EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQ 273

Query: 4271 LPEGRAR-NHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLG--- 4326
            L  G      + P+ I  +    I  ++ G  HT  +   G +Y +G    G+LGLG   
Sbjct: 274  LGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333

Query: 4327 HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAP 4361
             TNH   PTL +      V+ ++ G CH   + AP
Sbjct: 334  FTNHF-IPTLCSNFLRFIVKLVACGGCHMVVFAAP 367



 Score =  146 bits (369), Expect = 4e-34
 Identities = 106/323 (32%), Positives = 167/323 (51%), Gaps = 17/323 (5%)

Query: 3995 GKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQV---ICGQNCTFVIQANGTVLAC 4051
            G   +Y++G+   GQL    ++ +         + ++V    CG+N T V    G V A 
Sbjct: 52   GNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYAT 111

Query: 4052 GEGSYGRLGQGNSDDLHVLTVISALQG-FVVTQLVTSCGSDGHSMALTESGEVFSWGDGD 4110
            G  + G+LG G++++ +   VIS       + QL  S GS+  S ALTE G +F WGD  
Sbjct: 112  GGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQL--SAGSN-TSAALTEDGRLFMWGDNS 168

Query: 4111 YGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 4170
             G++G  N      P+Q+    G+ V  +SCG+ HSA VT+DG+L+ FG  + G+LGL N
Sbjct: 169  EGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPN 226

Query: 4171 --TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 4228
                N + P+ V+ +   ++ QVACG  HT+ ++ +   V+ FG G +G+LGLG    ++
Sbjct: 227  QLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENA--VYTFGLGQFGQLGLGTFLFET 283

Query: 4229 S-PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDR--LIGLPEGRARNHNRPQQI 4285
            S P+ I+ +    I  ++CG   +  +T  G +YTFG  R   +GL      NH  P   
Sbjct: 284  SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLC 343

Query: 4286 PVLAGVIIEDVAVGAEHTLALAS 4308
                  I++ VA G  H +  A+
Sbjct: 344  SNFLRFIVKLVACGGCHMVVFAA 366



 Score =  143 bits (360), Expect = 5e-33
 Identities = 88/277 (31%), Positives = 150/277 (54%), Gaps = 10/277 (3%)

Query: 4087 SCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHS 4146
            SCG D HS  +T + +++ +G  ++G+LG G+     +P  ++AL+ E+V   +CG  H+
Sbjct: 41   SCG-DEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 4147 AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEG-YQIGQVACGLNHTLAVSADG 4205
             V T  G ++  G  + G+LGLG+T  +     ++     ++I Q++ G N + A++ DG
Sbjct: 100  LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 4206 SMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG- 4264
             + + +GD   G++GL N +    PQ++ +  G  +  ++CG   S  +T DG +Y FG 
Sbjct: 160  RL-FMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGE 216

Query: 4265 -QDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQL 4323
             ++  +GLP     NH  PQ +  +   +I+ VA G EHT+ L  N  VY +G    GQL
Sbjct: 217  PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQL 274

Query: 4324 GLG-HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWT 4359
            GLG       EP ++  ++ + +  IS G  H+A  T
Sbjct: 275  GLGTFLFETSEPKVIENIRDQTISYISCGENHTALIT 311



 Score =  111 bits (278), Expect = 2e-23
 Identities = 89/334 (26%), Positives = 157/334 (47%), Gaps = 13/334 (3%)

Query: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSD 467
           +  G   + V++ +  +   G  ++G+LGLG   ++S + K T       +KV  +    
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG---SKSAISKPTCVKALKPEKVKLAACGR 96

Query: 468 GHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
            HTL  T  G V++ G  + G+LG G++  +    +I        +  +SAG   SAA+T
Sbjct: 97  NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156

Query: 528 EDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFG 587
           EDG L+ WG+   G++G  + ++  +P  V     V  +SCG  H+  ++ DG  ++ FG
Sbjct: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGE-LYVFG 215

Query: 588 GGDNGKLGHGD--TNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCG--AC 643
             +NGKLG  +        P+++  +    I+  C G + ++ LT    VY +G G    
Sbjct: 216 EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVAC-GGEHTVVLTENA-VYTFGLGQFGQ 273

Query: 644 LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQG--N 701
           LG G+       PK+IE +    I  +S G++H   ++    +Y +G+   G+ G G  N
Sbjct: 274 LGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333

Query: 702 STGPITKPKKVSGLDGIAIQQISAGTSHSLAWTA 735
            T     P   S      ++ ++ G  H + + A
Sbjct: 334 FTNHFI-PTLCSNFLRFIVKLVACGGCHMVVFAA 366



 Score = 90.9 bits (224), Expect = 3e-17
 Identities = 70/228 (30%), Positives = 117/228 (51%), Gaps = 9/228 (3%)

Query: 512 VVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCG 569
           V V +S G  HSA VT + +LY +G  ++G+LG G  ++ + PT VK +    V   +CG
Sbjct: 36  VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95

Query: 570 SSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMF-IRKVCAGSQSSLA 628
            +HT+ +S +G  V++ GG + G+LG GDT       VI        I+++ AGS +S A
Sbjct: 96  RNHTL-VSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154

Query: 629 LTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVD-VSIGDSHCLALSHDNEVY 687
           LT  G+++ WG  +    G    + +   + +++   + V  +S G  H   ++ D E+Y
Sbjct: 155 LTEDGRLFMWGDNSEGQIGLKNVSNV--CVPQQVTIGKPVSWISCGYYHSAFVTTDGELY 212

Query: 688 AWGNNSMGQCGQGNS-TGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
            +G    G+ G  N   G    P+ VS +    I Q++ G  H++  T
Sbjct: 213 VFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLT 259



 Score = 87.4 bits (215), Expect = 3e-16
 Identities = 63/223 (28%), Positives = 109/223 (48%), Gaps = 13/223 (5%)

Query: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRAC 427
           ++E   +++WG NS  Q+       +  P+          I  G Y +  ++TDG +   
Sbjct: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVF 214

Query: 428 GKGSYGRLGLGDS--NNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDG 485
           G+   G+LGL +    N  T + ++  P + I+     +    HT+  T E  V+++G G
Sbjct: 215 GEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGE----HTVVLT-ENAVYTFGLG 269

Query: 486 DYGKLGHGNSSTQ-KYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544
            +G+LG G    +   PK+I+  ++ + +  +S G  H+A +T+ G +YT+G+G  G+LG
Sbjct: 270 QFGQLGLGTFLFETSEPKVIEN-IRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328

Query: 545 HGDSNSRN--IPTLVKDISN--VGEVSCGSSHTIALSKDGRTV 583
            G  N  N  IPTL  +     V  V+CG  H +  +   R V
Sbjct: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGV 371



 Score = 33.1 bits (74), Expect = 6.9
 Identities = 17/58 (29%), Positives = 27/58 (46%), Gaps = 2/58 (3%)

Query: 1321 SSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEGHPEPEDEEEEREHE 1378
            + ++ W  + +D  + + +E       +   EMEE  E +  EG  E  D EEE E E
Sbjct: 697  AEKEEW--KKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKE 752


>gi|114520609 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score =  145 bits (366), Expect = 1e-33
 Identities = 103/355 (29%), Positives = 182/355 (51%), Gaps = 23/355 (6%)

Query: 4495 RQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNAT 4554
            R+++ +  +D  L +R W ++  GE   D GGV  +    + +E+      L   S    
Sbjct: 558  RRIMGVKRADF-LKARLW-IEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDN 615

Query: 4555 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLT 4614
              +  N      N   C ++HL  FKF+G + G+A+   K LD       +K +   P+T
Sbjct: 616  YTLQINP-----NSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPIT 670

Query: 4615 LEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIP 4674
            L D+E VD  Y  +L  IL   ++  TE     +I  + F GQ+   ++     GG+ I 
Sbjct: 671  LHDMESVDSEYYNSLRWIL---ENDPTELDLRFIIDEELF-GQTHQHELK---NGGSEIV 723

Query: 4675 LTFSNRKEYVERAIEYR-LHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEI 4733
            +T  N+KEY+   I++R ++ + +Q+AA +EG   ++P  L+ +    +LE ++CG+ ++
Sbjct: 724  VTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDV 783

Query: 4734 SVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPAN------T 4786
             V   ++  +Y+      HQ++QWFW  +    +E+R+  ++FV+G SR+P N       
Sbjct: 784  DVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYG 843

Query: 4787 ADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSID 4841
            ++  Q F + +   P + LP + TCF +L LPPY S   + ++L+ AI N +  D
Sbjct: 844  SNGPQSFTVEQWGTP-EKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 897


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score =  145 bits (366), Expect = 1e-33
 Identities = 103/355 (29%), Positives = 182/355 (51%), Gaps = 23/355 (6%)

Query: 4495 RQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNAT 4554
            R+++ +  +D  L +R W ++  GE   D GGV  +    + +E+      L   S    
Sbjct: 905  RRIMGVKRADF-LKARLW-IEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDN 962

Query: 4555 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLT 4614
              +  N      N   C ++HL  FKF+G + G+A+   K LD       +K +   P+T
Sbjct: 963  YTLQINP-----NSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPIT 1017

Query: 4615 LEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIP 4674
            L D+E VD  Y  +L  IL   ++  TE     +I  + F GQ+   ++     GG+ I 
Sbjct: 1018 LHDMESVDSEYYNSLRWIL---ENDPTELDLRFIIDEELF-GQTHQHELK---NGGSEIV 1070

Query: 4675 LTFSNRKEYVERAIEYR-LHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEI 4733
            +T  N+KEY+   I++R ++ + +Q+AA +EG   ++P  L+ +    +LE ++CG+ ++
Sbjct: 1071 VTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDV 1130

Query: 4734 SVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPAN------T 4786
             V   ++  +Y+      HQ++QWFW  +    +E+R+  ++FV+G SR+P N       
Sbjct: 1131 DVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYG 1190

Query: 4787 ADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSID 4841
            ++  Q F + +   P + LP + TCF +L LPPY S   + ++L+ AI N +  D
Sbjct: 1191 SNGPQSFTVEQWGTP-EKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1244


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
            sapiens]
          Length = 748

 Score =  144 bits (362), Expect = 3e-33
 Identities = 109/358 (30%), Positives = 174/358 (48%), Gaps = 32/358 (8%)

Query: 4489 IFVQIARQVVKLNASDLRLPSRAWK---VKLVGEGADDAGGVFDDTITEMCQELETGIVD 4545
            IF +  RQV+K+   DL      WK   +K  GE   D GGV  + +  +  E+      
Sbjct: 402  IFEESYRQVMKMRPKDL------WKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYG 455

Query: 4546 LLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVW 4605
            L   S +    +  N D      SA   EHL  F F+G +MG+A+     +D       +
Sbjct: 456  LFQYSRDDIYTLQINPD------SAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFY 509

Query: 4606 KQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVP 4665
            KQL    +TL+D+E VD     +L  IL  + +G+ + +F         V  +A G+++ 
Sbjct: 510  KQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTF--------CVEHNAYGEIIQ 561

Query: 4666 --IIPGGNSIPLTFSNRKEYVERAIEYR-LHEMDRQVAAVREGMSWIVPVPLLSLLTAKQ 4722
              + P G SIP+   N+KEYV   + +R L  ++ Q  A+++G + ++P  LL     K+
Sbjct: 562  HELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKE 621

Query: 4723 LEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRL 4782
            LE ++CG+ +I V   K   R +       +V+WFW  +E F  E R   ++FV+G SR+
Sbjct: 622  LELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRV 681

Query: 4783 PANTADISQ------RFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAI 4834
            P       Q       F I ++D   ++LP + TCF ++ +PPY S   + E+L  AI
Sbjct: 682  PLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAI 739


>gi|57242759 regulator of chromosome condensation (RCC1) and BTB (POZ)
            domain containing protein 1 [Homo sapiens]
          Length = 531

 Score =  140 bits (352), Expect = 4e-32
 Identities = 90/274 (32%), Positives = 155/274 (56%), Gaps = 7/274 (2%)

Query: 4090 SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF-KHSAV 4148
            S   ++ +T++ EVF +G      LG G++     P+++E L G+++  +S G   H  +
Sbjct: 30   SASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLL 89

Query: 4149 VTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGYQIGQVACGLNHTLAVSADGSM 4207
             T DG ++ +G+  Y +LG G T+    P +V T L   Q+ +VACG +H++A++ADG  
Sbjct: 90   STEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGE- 148

Query: 4208 VWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIG-IKKVACGTQFSVALTKDGHVYTFGQD 4266
            V+A+G  + G++G G++  + +P+K+     I  +  +ACG   S+A+  +G VY +G +
Sbjct: 149  VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYN 208

Query: 4267 RLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLG 4326
                L  G   N   P ++  L  V +  +  G  HTLAL   G +YAWG+N+ GQLG G
Sbjct: 209  GNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG 268

Query: 4327 HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTA 4360
            + N++  P  +  ++ + V +I+A  CHSA  +A
Sbjct: 269  NKNNLLSPAHIM-VEKERVVEIAA--CHSAHTSA 299



 Score =  136 bits (343), Expect = 4e-31
 Identities = 89/289 (30%), Positives = 147/289 (50%), Gaps = 6/289 (2%)

Query: 4045 NGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 4104
            N  V   G      LG G++    V   +  L G  +  L  S GS  H +  TE G V+
Sbjct: 40   NDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSL--SYGSGPHVLLSTEDGVVY 97

Query: 4105 SWGDGDYGKLGHGNSDRQRRPRQI-EALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 4163
            +WG   Y +LG+G +++   P Q+   L  ++VV+++CG  HS  + +DG++F +G  + 
Sbjct: 98   AWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNC 157

Query: 4164 GRLGLGNTSNKKLPERVT-ALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 4222
            G++G G+T+N+  P +VT  L   ++  +ACG   ++AV  +G  V+ +G    G+LGLG
Sbjct: 158  GQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGE-VYGWGYNGNGQLGLG 216

Query: 4223 NSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRP 4282
            N+  + +P ++  L  + + ++ CG   ++ALT +G +Y +G +    L  G   N   P
Sbjct: 217  NNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSP 276

Query: 4283 QQIPVLAGVIIEDVAVGAEHT-LALASNGDVYAWGSNSEGQLGLGHTNH 4330
              I V    ++E  A  + HT  A    G VY WG      + L H  H
Sbjct: 277  AHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVILPHLTH 325



 Score =  129 bits (324), Expect = 7e-29
 Identities = 86/282 (30%), Positives = 145/282 (51%), Gaps = 9/282 (3%)

Query: 364 DAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSF--SDAQTIEAGQYCTFVIST- 420
           +A  V++  EV+V+G N S+ L  G  +  L PK          +++  G     ++ST 
Sbjct: 33  EALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTE 92

Query: 421 DGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVF 480
           DG V A G   Y +LG G +N    +  +    +  IK+V        H++A   +GEVF
Sbjct: 93  DGVVYAWGHNGYSQLGNGTTNQG--IAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVF 150

Query: 481 SWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF 540
           +WG  + G++G G+++ Q  P+ +   L  K VV ++ G   S AV ++GE+Y WG    
Sbjct: 151 AWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGN 210

Query: 541 GRLGHGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGD 598
           G+LG G++ ++  P  V  + +  V ++ CG +HT+AL+ +G  ++++G    G+LG G+
Sbjct: 211 GQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEG-LLYAWGANTYGQLGTGN 269

Query: 599 TNRVYKPKVIEALQGMFIR-KVCAGSQSSLALTSTGQVYAWG 639
            N +  P  I   +   +    C  + +S A T  G VY WG
Sbjct: 270 KNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311



 Score =  123 bits (308), Expect = 5e-27
 Identities = 87/253 (34%), Positives = 128/253 (50%), Gaps = 10/253 (3%)

Query: 456 SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVC 515
           SI+K      S    L  T   EVF +G      LG G++ +   PK ++G L GK +  
Sbjct: 20  SIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEG-LCGKKIKS 78

Query: 516 VSAGYR-HSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKD---ISNVGEVSCGSS 571
           +S G   H    TEDG +Y WG   + +LG+G +N    P  V     I  V EV+CGS 
Sbjct: 79  LSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSH 138

Query: 572 HTIALSKDGRTVWSFGGGDNGKLGHGDT-NRVYKPKVIEALQGMFIRKVCAGSQSSLALT 630
           H++AL+ DG  V+++G  + G++G G T N+    KV   L    +  +  G  SS+A+ 
Sbjct: 139 HSMALAADGE-VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVL 197

Query: 631 STGQVYAWGC--GACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYA 688
             G+VY WG      LG G++    L P  +  L +  +  +  G +H LAL+ +  +YA
Sbjct: 198 DNGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYA 256

Query: 689 WGNNSMGQCGQGN 701
           WG N+ GQ G GN
Sbjct: 257 WGANTYGQLGTGN 269



 Score =  121 bits (303), Expect = 2e-26
 Identities = 80/259 (30%), Positives = 125/259 (48%), Gaps = 6/259 (2%)

Query: 437 LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSS 496
           LG  +NQSTL     E     K  S S GS  H L  T +G V++WG   Y +LG+G ++
Sbjct: 54  LGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN 113

Query: 497 TQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTL 556
               P  +   L  K VV V+ G  HS A+  DGE++ WG  + G++G G + ++  P  
Sbjct: 114 QGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRK 173

Query: 557 VKD---ISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQG 613
           V +   I  V  ++CG + ++A+  +G  V+ +G   NG+LG G+      P  + AL  
Sbjct: 174 VTNCLHIKRVVGIACGQTSSMAVLDNGE-VYGWGYNGNGQLGLGNNGNQLTPVRVAALHS 232

Query: 614 MFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIG 673
           + + ++  G   +LALT  G +YAWG       G+     L       +   R+V+++  
Sbjct: 233 VCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAAC 292

Query: 674 DS--HCLALSHDNEVYAWG 690
            S     A +    VY WG
Sbjct: 293 HSAHTSAAKTQGGHVYMWG 311



 Score =  108 bits (271), Expect = 1e-22
 Identities = 67/216 (31%), Positives = 114/216 (52%), Gaps = 10/216 (4%)

Query: 526 VTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTV 583
           VT++ E++ +G      LG GD+ S  +P  ++ +    +  +S GS   + LS +   V
Sbjct: 37  VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96

Query: 584 WSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKV---CAGSQSSLALTSTGQVYAWGC 640
           +++G     +LG+G TN+   P  ++    + I++V     GS  S+AL + G+V+AWG 
Sbjct: 97  YAWGHNGYSQLGNGTTNQGIAP--VQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGY 154

Query: 641 GAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCG 698
             C  +G GS+       K+   L   R+V ++ G +  +A+  + EVY WG N  GQ G
Sbjct: 155 NNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLG 214

Query: 699 QGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
            GN+   +T P +V+ L  + + QI  G +H+LA T
Sbjct: 215 LGNNGNQLT-PVRVAALHSVCVNQIVCGYAHTLALT 249



 Score =  105 bits (261), Expect = 1e-21
 Identities = 66/228 (28%), Positives = 104/228 (45%), Gaps = 26/228 (11%)

Query: 3999 VYLWGAGRHGQLAEAGRNVMVPAAAPS----FSQAQQVICGQNCTFVIQANGTVLACGEG 4054
            VY WG   + QL     N  +            Q  +V CG + +  + A+G V A G  
Sbjct: 96   VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYN 155

Query: 4055 SYGRLGQGNSDD----------LHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 4104
            + G++G G++ +          LH+  V+             +CG    SMA+ ++GEV+
Sbjct: 156  NCGQVGSGSTANQPTPRKVTNCLHIKRVVGI-----------ACGQTS-SMAVLDNGEVY 203

Query: 4105 SWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYG 4164
             WG    G+LG GN+  Q  P ++ AL    V Q+ CG+ H+  +T +G L+ +G   YG
Sbjct: 204  GWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYG 263

Query: 4165 RLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212
            +LG GN +N   P  +   +   +   AC   HT A    G  V+ +G
Sbjct: 264  QLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311



 Score = 75.1 bits (183), Expect = 2e-12
 Identities = 48/168 (28%), Positives = 76/168 (45%), Gaps = 6/168 (3%)

Query: 373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT---IEAGQYCTFVISTDGSVRACGK 429
           EV+ WG N+  Q+  G+      P+   +    +    I  GQ  +  +  +G V   G 
Sbjct: 148 EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGY 207

Query: 430 GSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGK 489
              G+LGLG++ NQ T  ++       + ++        HTLA T EG +++WG   YG+
Sbjct: 208 NGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYA---HTLALTDEGLLYAWGANTYGQ 264

Query: 490 LGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGE 537
           LG GN +    P  I    +  V +        SAA T+ G +Y WG+
Sbjct: 265 LGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312



 Score = 66.6 bits (161), Expect = 6e-10
 Identities = 48/141 (34%), Positives = 71/141 (50%), Gaps = 10/141 (7%)

Query: 616 IRKVCA-GSQSSLAL--TSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDV 670
           IRK C  G+ +S AL  T   +V+ +G     CLG G +++T L PK +E L   +I  +
Sbjct: 21  IRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQST-LVPKKLEGLCGKKIKSL 79

Query: 671 SIGDS-HCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSH 729
           S G   H L  + D  VYAWG+N   Q G G +   I   +  + L    + +++ G+ H
Sbjct: 80  SYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHH 139

Query: 730 SLAWTALPRDRQVVAWHRPYC 750
           S+   AL  D +V AW    C
Sbjct: 140 SM---ALAADGEVFAWGYNNC 157


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
          Length = 862

 Score =  139 bits (351), Expect = 5e-32
 Identities = 105/356 (29%), Positives = 177/356 (49%), Gaps = 24/356 (6%)

Query: 4487 KPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDL 4546
            K +F    +Q++  +  DLR   R W +   GE   D GGV  +    +  E+       
Sbjct: 514  KTLFEDSFQQIMSFSPQDLR--RRLWVI-FPGEEGLDYGGVAREWFFLLSHEV------- 563

Query: 4547 LIPSPNATAEVGYNRDRFLFNPSACLD-EHLMQFKFLGILMGVAIRTKKPLDLHLAPLVW 4605
            L P        G +      NP++ ++ +HL  F+F+G  + +A+   K +D   +   +
Sbjct: 564  LNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFY 623

Query: 4606 KQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVP 4665
            K++   P+ L+DLE +D    +  NS++ ++++ I E        +D  +    + K   
Sbjct: 624  KRILNKPVGLKDLESID---PEFYNSLIWVKENNIEECDLEMYFSVDKEI--LGEIKSHD 678

Query: 4666 IIPGGNSIPLTFSNRKEYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLE 4724
            + P G +I +T  N++EY+    E+RL   ++ Q  A  EG + I+P   L    AK+LE
Sbjct: 679  LKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELE 738

Query: 4725 QMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLP- 4783
             ++CGM EI +   ++   YR      + + WFW  ++E  NE+R+  ++FV+G  RLP 
Sbjct: 739  VLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPV 798

Query: 4784 ANTADI-----SQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAI 4834
               AD+      Q+F I KV +  + LP S TCF +L LPPY S   + E+L +AI
Sbjct: 799  GGFADLMGSNGPQKFCIEKVGKE-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI 853


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score =  139 bits (351), Expect = 5e-32
 Identities = 95/328 (28%), Positives = 158/328 (48%), Gaps = 20/328 (6%)

Query: 4518 GEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSA-CLDEHL 4576
            GE   DAGG+  +    + +E+   +  L   SP        +R  +  NPS+ C   HL
Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPG-------DRVTYTINPSSHCNPNHL 4104

Query: 4577 MQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIE 4636
              FKF+G ++  A+   + L+ +     +K +    +   D+E  D  + Q L  +L  +
Sbjct: 4105 SYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEND 4164

Query: 4637 DSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLH-EM 4695
             S +  +     +   + V +    ++  + P G +I +T  N+KEYV    + R+   +
Sbjct: 4165 VSTLGYD-----LTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAI 4219

Query: 4696 DRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQ 4755
             +Q+AA  EG   I+P  L+S+ T ++LE ++ G+P I ++ LK    Y +       +Q
Sbjct: 4220 RKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQ 4279

Query: 4756 WFWHTLEEFSNEERVLFMRFVSGRSRLP------ANTADISQRFQIMKVDRPYDSLPTSQ 4809
            WFW  L  F   +R  F++FV+G S++P          +  Q+FQI + DR  D LP++ 
Sbjct: 4280 WFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAH 4339

Query: 4810 TCFFQLRLPPYSSQLVMAERLRYAINNC 4837
            TCF QL LP Y S   +   L  AI  C
Sbjct: 4340 TCFNQLDLPAYESFEKLRHMLLLAIQEC 4367



 Score = 38.5 bits (88), Expect = 0.16
 Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 2/78 (2%)

Query: 2630 AQTPVTTSPSASSTTSFMSSSLEDTTTA--TTPVTDTETVPASESPGVMPLSLLRQMFSS 2687
            ++    +   ASSTT+  S++   TTTA  TTP   T   P + +P ++  + +  +  +
Sbjct: 3470 SEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVA 3529

Query: 2688 YPTTTVLPTRRAQTPPIS 2705
              TT   PT    T  IS
Sbjct: 3530 ASTTVTTPTTATTTVSIS 3547


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score =  139 bits (350), Expect = 7e-32
 Identities = 75/206 (36%), Positives = 116/206 (56%), Gaps = 4/206 (1%)

Query: 4031 QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNS-DDLHVLTVISALQGFVVTQLVTSCG 4089
            Q+ CG   +  +   G + A G+  +G+LG G          ++  L G  + Q+     
Sbjct: 142  QITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQI---SA 198

Query: 4090 SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVV 4149
             + HSMAL+ SG ++SWG  + G+LG G+++ +  P  IE L  ++V  ++CG  HSA++
Sbjct: 199  GEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALL 258

Query: 4150 TSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVW 4209
            T DG LFTFG G +G+LG  +T N+  P  V  L GY++ Q+ACG  HTLA  +D   V+
Sbjct: 259  TQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVF 318

Query: 4210 AFGDGDYGKLGLGNSTAKSSPQKIDV 4235
            +FG G  G+LG G +  +  P  + V
Sbjct: 319  SFGSGKDGQLGNGGTRDQLMPLPVKV 344



 Score =  125 bits (313), Expect = 1e-27
 Identities = 70/200 (35%), Positives = 117/200 (58%), Gaps = 3/200 (1%)

Query: 4131 LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SNKKLPERVTALEGYQIG 4189
            LQ ++++Q++CG  HS  ++  G+LF +G   +G+LG+G    +   P+ V  L G  + 
Sbjct: 135  LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194

Query: 4190 QVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQ 4249
            Q++ G  H++A+S  G+ ++++G  + G+LGLG++ +K  P  I+ L    ++ VACG  
Sbjct: 195  QISAGEAHSMALSMSGN-IYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGS 253

Query: 4250 FSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASN 4309
             S  LT+DG ++TFG  +   L     +N  RP  +  L G  +  +A G  HTLA  S+
Sbjct: 254  HSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSD 313

Query: 4310 -GDVYAWGSNSEGQLGLGHT 4328
             G V+++GS  +GQLG G T
Sbjct: 314  LGKVFSFGSGKDGQLGNGGT 333



 Score =  124 bits (312), Expect = 2e-27
 Identities = 92/341 (26%), Positives = 161/341 (47%), Gaps = 33/341 (9%)

Query: 307 RRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI---QTG 363
           RR+  S+A ++   +P ++      L+ +A  L   + R      + C SP  +   + G
Sbjct: 10  RRNGRSTAGKAAATQPAKSPGAQLWLFPSAAGLHRALLRRVEVTRQLCCSPGRLAVLERG 69

Query: 364 DAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGS 423
            A +          G+ +   +  G   KI             +++ G     ++S+DG 
Sbjct: 70  GAGVQVHQLLAGSGGARTPKCIKLGKNMKI------------HSVDQGAEHMLILSSDGK 117

Query: 424 VRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWG 483
                          + +N S +K L FE     KK+      D H+LA +  GE+F+WG
Sbjct: 118 PF-------------EYDNYS-MKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWG 163

Query: 484 DGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRL 543
              +G+LG G          I   L G  +  +SAG  HS A++  G +Y+WG+ + G+L
Sbjct: 164 QNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQL 223

Query: 544 GHGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNR 601
           G G + S++ P+L++ + N  V  V+CG SH+  L++DG  +++FG G +G+LGH  T  
Sbjct: 224 GLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDG-LLFTFGAGKHGQLGHNSTQN 282

Query: 602 VYKPKVIEALQGMFIRKVCAGSQSSLALTS-TGQVYAWGCG 641
             +P ++  L G  + ++  G   +LA  S  G+V+++G G
Sbjct: 283 ELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSG 323



 Score =  120 bits (301), Expect = 3e-26
 Identities = 69/228 (30%), Positives = 121/228 (53%), Gaps = 5/228 (2%)

Query: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSD 467
           I  G Y +  +S  G + A G+  +G+LG+G     +T  ++    H +   ++     +
Sbjct: 143 ITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIV--EHLAGVPLAQISAGE 200

Query: 468 GHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
            H++A +  G ++SWG  + G+LG G++ ++  P LI+G L  + V  V+ G  HSA +T
Sbjct: 201 AHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG-LDNQKVEFVACGGSHSALLT 259

Query: 528 EDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWS 585
           +DG L+T+G G  G+LGH  + +   P LV ++    V +++CG  HT+A   D   V+S
Sbjct: 260 QDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFS 319

Query: 586 FGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTG 633
           FG G +G+LG+G T     P  ++      ++     S+  L + + G
Sbjct: 320 FGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGG 367



 Score =  110 bits (276), Expect = 3e-23
 Identities = 69/239 (28%), Positives = 124/239 (51%), Gaps = 13/239 (5%)

Query: 4123 RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA 4182
            R P+ I+  +  ++  +  G +H  +++SDGK F + N     L   +   +K       
Sbjct: 86   RTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFESILQEK------- 138

Query: 4183 LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNS-TAKSSPQKIDVLCGIGI 4241
                +I Q+ CG  H+LA+S  G + +A+G   +G+LG+G    + ++PQ ++ L G+ +
Sbjct: 139  ----KIIQITCGDYHSLALSKGGEL-FAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPL 193

Query: 4242 KKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAE 4301
             +++ G   S+AL+  G++Y++G++    L  G   + + P  I  L    +E VA G  
Sbjct: 194  AQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGS 253

Query: 4302 HTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTA 4360
            H+  L  +G ++ +G+   GQLG   T +   P LV  L G  V QI+ GR H+ A+ +
Sbjct: 254  HSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312



 Score =  109 bits (273), Expect = 6e-23
 Identities = 82/294 (27%), Positives = 145/294 (49%), Gaps = 29/294 (9%)

Query: 455 RSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVV 514
           +++K  S  +G++ H L  +++G+ F +           ++ + K+ +  +  LQ K ++
Sbjct: 95  KNMKIHSVDQGAE-HMLILSSDGKPFEY-----------DNYSMKHLRF-ESILQEKKII 141

Query: 515 CVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDS-NSRNIPTLVKDISNV--GEVSCGSS 571
            ++ G  HS A+++ GEL+ WG+   G+LG G    S   P +V+ ++ V   ++S G +
Sbjct: 142 QITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEA 201

Query: 572 HTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTS 631
           H++ALS  G  ++S+G  + G+LG G T     P +IE L    +  V  G   S  LT 
Sbjct: 202 HSMALSMSGN-IYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQ 260

Query: 632 TGQVYAWGCGACLGCG-SSEATALRPKLIEELAATRIVDVSIGDSHCLALSHD-NEVYAW 689
            G ++ +G G     G +S    LRP L+ EL   R+  ++ G  H LA   D  +V+++
Sbjct: 261 DGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSF 320

Query: 690 GNNSMGQCGQGNSTGPITK-PKKVSGLDGIAIQ---------QISAGTSHSLAW 733
           G+   GQ G G +   +   P KVS  + + ++          I+ G    L W
Sbjct: 321 GSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQSILLW 374



 Score = 95.5 bits (236), Expect = 1e-18
 Identities = 58/193 (30%), Positives = 99/193 (51%), Gaps = 13/193 (6%)

Query: 4168 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 4227
            L  +   + P+ +   +  +I  V  G  H L +S+DG         +Y    + +   +
Sbjct: 79   LAGSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPF------EYDNYSMKHLRFE 132

Query: 4228 SSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA-RNHNRPQQIP 4286
            S  Q+  ++      ++ CG   S+AL+K G ++ +GQ+    L  GR   +   PQ + 
Sbjct: 133  SILQEKKII------QITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVE 186

Query: 4287 VLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVR 4346
             LAGV +  ++ G  H++AL+ +G++Y+WG N  GQLGLGHT    +P+L+ GL  + V 
Sbjct: 187  HLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVE 246

Query: 4347 QISAGRCHSAAWT 4359
             ++ G  HSA  T
Sbjct: 247  FVACGGSHSALLT 259



 Score = 94.4 bits (233), Expect = 3e-18
 Identities = 71/248 (28%), Positives = 124/248 (50%), Gaps = 19/248 (7%)

Query: 491 GHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNS 550
           G G + T K  KL +       +  V  G  H   ++ DG+ + +       L       
Sbjct: 81  GSGGARTPKCIKLGKN----MKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHL------- 129

Query: 551 RNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDT-NRVYKPKVIE 609
               +++++   + +++CG  H++ALSK G  ++++G   +G+LG G        P+++E
Sbjct: 130 -RFESILQE-KKIIQITCGDYHSLALSKGGE-LFAWGQNLHGQLGVGRKFPSTTTPQIVE 186

Query: 610 ALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRI 667
            L G+ + ++ AG   S+AL+ +G +Y+WG   C  LG G +E+    P LIE L   ++
Sbjct: 187 HLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKD-DPSLIEGLDNQKV 245

Query: 668 VDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGT 727
             V+ G SH   L+ D  ++ +G    GQ G  NST    +P  V+ L G  + QI+ G 
Sbjct: 246 EFVACGGSHSALLTQDGLLFTFGAGKHGQLGH-NSTQNELRPCLVAELVGYRVTQIACGR 304

Query: 728 SHSLAWTA 735
            H+LA+ +
Sbjct: 305 WHTLAYVS 312



 Score = 93.2 bits (230), Expect = 6e-18
 Identities = 57/186 (30%), Positives = 97/186 (52%), Gaps = 10/186 (5%)

Query: 3998 DVYLWGAGRHGQLAEAGR---NVMVPAAAPSFS--QAQQVICGQNCTFVIQANGTVLACG 4052
            +++ WG   HGQL   GR   +   P      +     Q+  G+  +  +  +G + + G
Sbjct: 158  ELFAWGQNLHGQLG-VGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWG 216

Query: 4053 EGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 4112
            +   G+LG G+++     ++I  L    V     +CG   HS  LT+ G +F++G G +G
Sbjct: 217  KNECGQLGLGHTESKDDPSLIEGLDNQKVE--FVACGG-SHSALLTQDGLLFTFGAGKHG 273

Query: 4113 KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD-GKLFTFGNGDYGRLGLGNT 4171
            +LGH ++  + RP  +  L G  V Q++CG  H+    SD GK+F+FG+G  G+LG G T
Sbjct: 274  QLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGT 333

Query: 4172 SNKKLP 4177
             ++ +P
Sbjct: 334  RDQLMP 339



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 61/238 (25%), Positives = 115/238 (48%), Gaps = 16/238 (6%)

Query: 340 FEEVCRMASDYSRTCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQ-EKILQPKL 398
           FE + +       TC    S+       +S+  E++ WG N   QL  G +      P++
Sbjct: 131 FESILQEKKIIQITCGDYHSLA------LSKGGELFAWGQNLHGQLGVGRKFPSTTTPQI 184

Query: 399 APSFSDAQT--IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRS 456
               +      I AG+  +  +S  G++ + GK   G+LGLG + ++     +    ++ 
Sbjct: 185 VEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQK 244

Query: 457 IKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCV 516
           ++ V+       H+   T +G +F++G G +G+LGH ++  +  P L+   L G  V  +
Sbjct: 245 VEFVACG---GSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLV-AELVGYRVTQI 300

Query: 517 SAGYRHSAAVTED-GELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHT 573
           + G  H+ A   D G+++++G G  G+LG+G +  + +P  VK +S+  E+    SHT
Sbjct: 301 ACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVK-VSSSEELKL-ESHT 356



 Score = 75.5 bits (184), Expect = 1e-12
 Identities = 66/264 (25%), Positives = 125/264 (47%), Gaps = 11/264 (4%)

Query: 4578 QFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIED 4637
            ++ F G+L G+++      +L     ++K+L     +LEDL+E+     + L ++L  +D
Sbjct: 766  RYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLL--DD 823

Query: 4638 SGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDR 4697
             G   ++F E+  +   V    D     +IP G+SI +  +N+++YV + I Y  ++  +
Sbjct: 824  EG---DNFEEVFYIHFNVHW--DRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVK 878

Query: 4698 QV-AAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQ 4755
             V    R G   +    ++ L   ++L+ ++ G  +   +  +K  RY    +  H  + 
Sbjct: 879  AVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIV 938

Query: 4756 WFWHTLEEFSNEERVLFMRFVSGRSRLPANTAD-ISQRFQIMKVDRPYDSLPTSQTCFFQ 4814
             FW    + + EE+  F+ F++G  RL     + +   F   +     D +  + TCF  
Sbjct: 939  MFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNERDPI-RALTCFSV 997

Query: 4815 LRLPPYSSQLVMAERLRYAINNCR 4838
            L LP YS+   + E L+ AINN R
Sbjct: 998  LFLPKYSTMETVEEALQEAINNNR 1021



 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 49/149 (32%), Positives = 73/149 (48%), Gaps = 13/149 (8%)

Query: 605 PKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAA 664
           PK I+  + M I  V  G++  L L+S G+ + +         +     LR + I  L  
Sbjct: 88  PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYD--------NYSMKHLRFESI--LQE 137

Query: 665 TRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQIS 724
            +I+ ++ GD H LALS   E++AWG N  GQ G G      T P+ V  L G+ + QIS
Sbjct: 138 KKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQIS 197

Query: 725 AGTSHSLAWTALPRDRQVVAWHRPYCVDL 753
           AG +HS+   AL     + +W +  C  L
Sbjct: 198 AGEAHSM---ALSMSGNIYSWGKNECGQL 223



 Score = 58.2 bits (139), Expect = 2e-07
 Identities = 41/146 (28%), Positives = 75/146 (51%), Gaps = 13/146 (8%)

Query: 3998 DVYLWGAGRHGQLAEAGRNVMVPAAAPSF------SQAQQVICGQNCTFVIQANGTVLAC 4051
            ++Y WG    GQL   G         PS        + + V CG + + ++  +G +   
Sbjct: 211  NIYSWGKNECGQL---GLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTF 267

Query: 4052 GEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMA-LTESGEVFSWGDGD 4110
            G G +G+LG  ++ +     +++ L G+ VTQ+  +CG   H++A +++ G+VFS+G G 
Sbjct: 268  GAGKHGQLGHNSTQNELRPCLVAELVGYRVTQI--ACGR-WHTLAYVSDLGKVFSFGSGK 324

Query: 4111 YGKLGHGNSDRQRRPRQIEALQGEEV 4136
             G+LG+G +  Q  P  ++    EE+
Sbjct: 325  DGQLGNGGTRDQLMPLPVKVSSSEEL 350


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
            sapiens]
          Length = 757

 Score =  137 bits (345), Expect = 3e-31
 Identities = 102/358 (28%), Positives = 176/358 (49%), Gaps = 29/358 (8%)

Query: 4489 IFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLI 4548
            IF +  RQ++K+   DL+   +   VK  GE   D GGV  + +  +C E+      L  
Sbjct: 408  IFEESYRQIMKMRPKDLK---KRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQ 464

Query: 4549 PSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQL 4608
             S +    +  N D  + NP     +HL  F F+G +MG+A+     ++       +KQL
Sbjct: 465  YSTDNIYMLQINPDSSI-NP-----DHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQL 518

Query: 4609 CCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVP--I 4666
               P+ L DLE VD    ++L  IL  + + + + +F         V  +A G+++   +
Sbjct: 519  LGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTF--------CVEHNAFGRILQHEL 570

Query: 4667 IPGGNSIPLTFSNRKEYVERAIEYR-LHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQ 4725
             P G ++P+T  N+KEYV   + +R +  ++ Q  A+++G + ++P  LL     K+LE 
Sbjct: 571  KPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELEL 630

Query: 4726 MVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLP-- 4783
            ++ G+ +I +   K   R +       +V+WFW  +E F  E R   ++FV+G +R+P  
Sbjct: 631  IIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQ 690

Query: 4784 ------ANTADISQR-FQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAI 4834
                   +T     R F I  +D   D+LP + TCF ++ +PPY S   + E+L  A+
Sbjct: 691  GFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAV 748


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
            sapiens]
          Length = 731

 Score =  137 bits (345), Expect = 3e-31
 Identities = 102/358 (28%), Positives = 176/358 (49%), Gaps = 29/358 (8%)

Query: 4489 IFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLI 4548
            IF +  RQ++K+   DL+   +   VK  GE   D GGV  + +  +C E+      L  
Sbjct: 382  IFEESYRQIMKMRPKDLK---KRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQ 438

Query: 4549 PSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQL 4608
             S +    +  N D  + NP     +HL  F F+G +MG+A+     ++       +KQL
Sbjct: 439  YSTDNIYMLQINPDSSI-NP-----DHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQL 492

Query: 4609 CCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVP--I 4666
               P+ L DLE VD    ++L  IL  + + + + +F         V  +A G+++   +
Sbjct: 493  LGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTF--------CVEHNAFGRILQHEL 544

Query: 4667 IPGGNSIPLTFSNRKEYVERAIEYR-LHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQ 4725
             P G ++P+T  N+KEYV   + +R +  ++ Q  A+++G + ++P  LL     K+LE 
Sbjct: 545  KPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELEL 604

Query: 4726 MVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLP-- 4783
            ++ G+ +I +   K   R +       +V+WFW  +E F  E R   ++FV+G +R+P  
Sbjct: 605  IIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQ 664

Query: 4784 ------ANTADISQR-FQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAI 4834
                   +T     R F I  +D   D+LP + TCF ++ +PPY S   + E+L  A+
Sbjct: 665  GFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAV 722


>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
            sapiens]
          Length = 596

 Score =  137 bits (344), Expect = 3e-31
 Identities = 74/169 (43%), Positives = 101/169 (59%), Gaps = 2/169 (1%)

Query: 4206 SMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQ 4265
            S+V+++GDGD+GKLG G S   + PQ I+ L G G+ ++ CG QF +ALTK G V+T+G+
Sbjct: 23   SLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 82

Query: 4266 DRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGL 4325
                 L      +  +PQ +  L G  I  VAVGA+H LA+  +G VYAWG N  GQ G 
Sbjct: 83   GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142

Query: 4326 GHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 4374
            G T   R+PTLV GL+G+ +  ++ G  HS AWT   V    P V  P+
Sbjct: 143  GTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT--VDVATPSVHEPV 189



 Score =  122 bits (305), Expect = 1e-26
 Identities = 67/153 (43%), Positives = 89/153 (58%), Gaps = 1/153 (0%)

Query: 4103 VFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGD 4162
            VFSWGDGD+GKLG G S+    P+ IE L G+ V Q+ CG +    +T  G ++T+G GD
Sbjct: 25   VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84

Query: 4163 YGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 4222
            Y RLG  +  + + P+ V  L G +I  VA G  H LAV  D   V+A+GD D+G+ G G
Sbjct: 85   YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAV-MDSGQVYAWGDNDHGQQGNG 143

Query: 4223 NSTAKSSPQKIDVLCGIGIKKVACGTQFSVALT 4255
             +T    P  +  L G  I  VACG+  SVA T
Sbjct: 144  TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176



 Score =  118 bits (295), Expect = 2e-25
 Identities = 64/155 (41%), Positives = 92/155 (59%), Gaps = 2/155 (1%)

Query: 583 VWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGA 642
           V+S+G GD GKLG G +     P+ IE L G  + ++  G+Q  LALT +G V+ WG G 
Sbjct: 25  VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84

Query: 643 CLGCGS-SEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGN 701
               G  S+    +P+++E L   +IV V++G  HCLA+    +VYAWG+N  GQ G G 
Sbjct: 85  YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGT 144

Query: 702 STGPITKPKKVSGLDGIAIQQISAGTSHSLAWTAL 736
           +T    KP  V GL+G  I  ++ G+SHS+AWT +
Sbjct: 145 TT-VNRKPTLVQGLEGQKIMCVACGSSHSVAWTTV 178



 Score =  113 bits (283), Expect = 4e-24
 Identities = 57/153 (37%), Positives = 96/153 (62%), Gaps = 3/153 (1%)

Query: 4048 VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 4107
            V + G+G +G+LG+G S+  ++   I  L G  V Q+   CG+    +ALT+SG V++WG
Sbjct: 25   VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQ-FLLALTKSGVVWTWG 81

Query: 4108 DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 4167
             GDY +LGH +    R+P+ +E L+G+++V ++ G +H   V   G+++ +G+ D+G+ G
Sbjct: 82   KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141

Query: 4168 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLA 4200
             G T+  + P  V  LEG +I  VACG +H++A
Sbjct: 142  NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVA 174



 Score =  110 bits (275), Expect = 3e-23
 Identities = 60/151 (39%), Positives = 90/151 (59%), Gaps = 4/151 (2%)

Query: 532 LYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVG--EVSCGSSHTIALSKDGRTVWSFGGG 589
           +++WG+GDFG+LG G S   NIP  ++ ++  G  ++ CG+   +AL+K G  VW++G G
Sbjct: 25  VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSG-VVWTWGKG 83

Query: 590 DNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS 649
           D  +LGH     V KP+V+E L+G  I  V  G+Q  LA+  +GQVYAWG       G+ 
Sbjct: 84  DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143

Query: 650 EATALR-PKLIEELAATRIVDVSIGDSHCLA 679
             T  R P L++ L   +I+ V+ G SH +A
Sbjct: 144 TTTVNRKPTLVQGLEGQKIMCVACGSSHSVA 174



 Score =  103 bits (256), Expect = 5e-21
 Identities = 58/158 (36%), Positives = 91/158 (57%), Gaps = 4/158 (2%)

Query: 476 EGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTW 535
           E  VFSWGDGD+GKLG G S     P+ I+  L G+ V  +  G +   A+T+ G ++TW
Sbjct: 22  ESLVFSWGDGDFGKLGRGGSEGCNIPQNIE-RLNGQGVCQIECGAQFLLALTKSGVVWTW 80

Query: 536 GEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGK 593
           G+GD+ RLGH        P +V+ +    +  V+ G+ H +A+   G+ V+++G  D+G+
Sbjct: 81  GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQ-VYAWGDNDHGQ 139

Query: 594 LGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTS 631
            G+G T    KP +++ L+G  I  V  GS  S+A T+
Sbjct: 140 QGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177



 Score = 93.2 bits (230), Expect = 6e-18
 Identities = 50/150 (33%), Positives = 85/150 (56%), Gaps = 6/150 (4%)

Query: 428 GKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDY 487
           G G +G+LG G S   +  + +     + + ++          LA T  G V++WG GDY
Sbjct: 29  GDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQ---FLLALTKSGVVWTWGKGDY 85

Query: 488 GKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGD 547
            +LGH +    + P++++G L+GK +V V+ G +H  AV + G++Y WG+ D G+ G+G 
Sbjct: 86  FRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGT 144

Query: 548 SNSRNIPTLVKDI--SNVGEVSCGSSHTIA 575
           +     PTLV+ +    +  V+CGSSH++A
Sbjct: 145 TTVNRKPTLVQGLEGQKIMCVACGSSHSVA 174



 Score = 83.2 bits (204), Expect = 6e-15
 Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 6/156 (3%)

Query: 3999 VYLWGAGRHGQLAEAGR---NVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGS 4055
            V+ WG G  G+L   G    N+       +     Q+ CG      +  +G V   G+G 
Sbjct: 25   VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84

Query: 4056 YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 4115
            Y RLG  +   +    V+  L+G  +  +        H +A+ +SG+V++WGD D+G+ G
Sbjct: 85   YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQ---HCLAVMDSGQVYAWGDNDHGQQG 141

Query: 4116 HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 4151
            +G +   R+P  ++ L+G++++ ++CG  HS   T+
Sbjct: 142  NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177



 Score = 73.9 bits (180), Expect = 4e-12
 Identities = 50/156 (32%), Positives = 75/156 (48%), Gaps = 6/156 (3%)

Query: 374 VYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT--IEAGQYCTFVISTDGSVRACGKGS 431
           V+ WG     +L  G  E    P+     +      IE G      ++  G V   GKG 
Sbjct: 25  VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84

Query: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491
           Y RLG    ++    K    E  R  K V  + G+  H LA    G+V++WGD D+G+ G
Sbjct: 85  YFRLG--HRSDVHVRKPQVVEGLRGKKIVHVAVGAQ-HCLAVMDSGQVYAWGDNDHGQQG 141

Query: 492 HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
           +G ++  + P L+QG L+G+ ++CV+ G  HS A T
Sbjct: 142 NGTTTVNRKPTLVQG-LEGQKIMCVACGSSHSVAWT 176



 Score = 35.4 bits (80), Expect = 1.4
 Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 1/53 (1%)

Query: 682 HDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
           +++ V++WG+   G+ G+G S G    P+ +  L+G  + QI  G    LA T
Sbjct: 21  YESLVFSWGDGDFGKLGRGGSEG-CNIPQNIERLNGQGVCQIECGAQFLLALT 72


>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
            protein ligase 1 [Homo sapiens]
          Length = 909

 Score =  137 bits (344), Expect = 3e-31
 Identities = 85/270 (31%), Positives = 146/270 (54%), Gaps = 13/270 (4%)

Query: 4574 EHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSIL 4633
            +HL  F+F G ++G+A+  ++ ++++     +K +  +P+  +D+  +D  Y + L  IL
Sbjct: 636  DHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWIL 695

Query: 4634 HIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRL- 4692
               D+ I++        +++ V  + +   VP+ PGG SI +T +N+ EYV+   E R+ 
Sbjct: 696  ---DNDISDLGLELTFSVETDVFGAMEE--VPLKPGGGSILVTQNNKAEYVQLVTELRMT 750

Query: 4693 HEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQH 4751
              +  Q+ A  +G    +P  L+ L    +LE ++ GMPEI V    K   Y    + + 
Sbjct: 751  RAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYERED 810

Query: 4752 QLVQWFWHTLEEFSNEERVLFMRFVSGRSRLP----ANTADIS--QRFQIMKVDRPYDSL 4805
             ++QWFW  +E+ + EERVL ++FV+G SR+P    AN    S  Q F I  V    + L
Sbjct: 811  PVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLL 870

Query: 4806 PTSQTCFFQLRLPPYSSQLVMAERLRYAIN 4835
            PTS TC   L+LP Y S+ ++ +RL  A++
Sbjct: 871  PTSSTCINMLKLPEYPSKEILKDRLLVALH 900


>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
            sapiens]
          Length = 1052

 Score =  135 bits (341), Expect = 8e-31
 Identities = 75/180 (41%), Positives = 104/180 (57%), Gaps = 3/180 (1%)

Query: 4196 NHTLAVSAD-GSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVAL 4254
            N+ L    + G +V+++GDGD+GKLG G S   + PQ I+ L G G+ ++ CG QF +AL
Sbjct: 664  NYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLAL 723

Query: 4255 TKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYA 4314
            TK G V+T+G+     L      +  +PQ +  L G  I  VAVGA+H LA+  +G VYA
Sbjct: 724  TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 783

Query: 4315 WGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 4374
            WG N  GQ G G T   R+P LV GL+G+ +  ++ G  HS AWT   V    P V  P+
Sbjct: 784  WGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDV--ATPSVHEPV 841



 Score =  123 bits (309), Expect = 4e-27
 Identities = 68/155 (43%), Positives = 90/155 (58%), Gaps = 1/155 (0%)

Query: 4101 GEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGN 4160
            G VFSWGDGD+GKLG G S+    P+ IE L G+ V Q+ CG +    +T  G ++T+G 
Sbjct: 675  GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734

Query: 4161 GDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLG 4220
            GDY RLG  +  + + P+ V  L G +I  VA G  H LAV  D   V+A+GD D+G+ G
Sbjct: 735  GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAV-MDSGQVYAWGDNDHGQQG 793

Query: 4221 LGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALT 4255
             G +T    P  +  L G  I  VACG+  SVA T
Sbjct: 794  NGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 828



 Score =  120 bits (300), Expect = 4e-26
 Identities = 72/184 (39%), Positives = 104/184 (56%), Gaps = 6/184 (3%)

Query: 558 KDISNVGEVSCG--SSHTIALSKD--GRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQG 613
           K + N   +S G  S +   L+K   G  V+S+G GD GKLG G +     P+ IE L G
Sbjct: 648 KSVGNWEYISTGKVSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNG 707

Query: 614 MFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGS-SEATALRPKLIEELAATRIVDVSI 672
             + ++  G+Q  LALT +G V+ WG G     G  S+    +P+++E L   +IV V++
Sbjct: 708 QGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAV 767

Query: 673 GDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732
           G  HCLA+    +VYAWG+N  GQ G G +T    KP  V GL+G  I  ++ G+SHS+A
Sbjct: 768 GAQHCLAVMDSGQVYAWGDNDHGQQGNGTTT-VNRKPMLVQGLEGQKIMCVACGSSHSVA 826

Query: 733 WTAL 736
           WT +
Sbjct: 827 WTTM 830



 Score =  115 bits (288), Expect = 1e-24
 Identities = 58/158 (36%), Positives = 98/158 (62%), Gaps = 3/158 (1%)

Query: 4043 QANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGE 4102
            +  G V + G+G +G+LG+G S+  ++   I  L G  V Q+   CG+    +ALT+SG 
Sbjct: 672  EMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQ-FLLALTKSGV 728

Query: 4103 VFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGD 4162
            V++WG GDY +LGH +    R+P+ +E L+G+++V ++ G +H   V   G+++ +G+ D
Sbjct: 729  VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 788

Query: 4163 YGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLA 4200
            +G+ G G T+  + P  V  LEG +I  VACG +H++A
Sbjct: 789  HGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVA 826



 Score =  112 bits (279), Expect = 1e-23
 Identities = 64/167 (38%), Positives = 94/167 (56%), Gaps = 4/167 (2%)

Query: 516 VSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVG--EVSCGSSHT 573
           VS  Y         G +++WG+GDFG+LG G S   NIP  ++ ++  G  ++ CG+   
Sbjct: 661 VSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFL 720

Query: 574 IALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTG 633
           +AL+K G  VW++G GD  +LGH     V KP+V+E L+G  I  V  G+Q  LA+  +G
Sbjct: 721 LALTKSG-VVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSG 779

Query: 634 QVYAWGCGACLGCGSSEATALR-PKLIEELAATRIVDVSIGDSHCLA 679
           QVYAWG       G+   T  R P L++ L   +I+ V+ G SH +A
Sbjct: 780 QVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVA 826



 Score = 92.4 bits (228), Expect = 1e-17
 Identities = 51/156 (32%), Positives = 87/156 (55%), Gaps = 6/156 (3%)

Query: 422 GSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481
           G V + G G +G+LG G S   +  + +     + + ++          LA T  G V++
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQ---FLLALTKSGVVWT 731

Query: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFG 541
           WG GDY +LGH +    + P++++G L+GK +V V+ G +H  AV + G++Y WG+ D G
Sbjct: 732 WGKGDYFRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHG 790

Query: 542 RLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSHTIA 575
           + G+G +     P LV+ +    +  V+CGSSH++A
Sbjct: 791 QQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVA 826



 Score = 84.7 bits (208), Expect = 2e-15
 Identities = 50/186 (26%), Positives = 92/186 (49%), Gaps = 14/186 (7%)

Query: 3977 DEQIMSW---ATSRPED-WHLGGKCD----VYLWGAGRHGQLAEAGR---NVMVPAAAPS 4025
            D+ + +W   +T +  D + L  KC+    V+ WG G  G+L   G    N+       +
Sbjct: 647  DKSVGNWEYISTGKVSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLN 706

Query: 4026 FSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLV 4085
                 Q+ CG      +  +G V   G+G Y RLG  +   +    V+  L+G  +  + 
Sbjct: 707  GQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVA 766

Query: 4086 TSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKH 4145
                   H +A+ +SG+V++WGD D+G+ G+G +   R+P  ++ L+G++++ ++CG  H
Sbjct: 767  VGAQ---HCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSH 823

Query: 4146 SAVVTS 4151
            S   T+
Sbjct: 824  SVAWTT 829



 Score = 73.9 bits (180), Expect = 4e-12
 Identities = 50/156 (32%), Positives = 75/156 (48%), Gaps = 6/156 (3%)

Query: 374 VYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT--IEAGQYCTFVISTDGSVRACGKGS 431
           V+ WG     +L  G  E    P+     +      IE G      ++  G V   GKG 
Sbjct: 677 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 736

Query: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491
           Y RLG    ++    K    E  R  K V  + G+  H LA    G+V++WGD D+G+ G
Sbjct: 737 YFRLG--HRSDVHVRKPQVVEGLRGKKIVHVAVGAQ-HCLAVMDSGQVYAWGDNDHGQQG 793

Query: 492 HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
           +G ++  + P L+QG L+G+ ++CV+ G  HS A T
Sbjct: 794 NGTTTVNRKPMLVQG-LEGQKIMCVACGSSHSVAWT 828


>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
            isoform 2 [Homo sapiens]
          Length = 431

 Score =  132 bits (332), Expect = 8e-30
 Identities = 104/358 (29%), Positives = 175/358 (48%), Gaps = 32/358 (8%)

Query: 4489 IFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLI 4548
            +F    +Q++ +   DLR   R   + + GE   D GG+  +    +  E+       L 
Sbjct: 85   LFEDSFQQIMNMKPYDLR---RRLYIIMRGEEGLDYGGIAREWFFLLSHEV-------LN 134

Query: 4549 PSPNATAEVGYNRDRFLFNPSACLD-EHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQ 4607
            P        G N      NP++ ++ +HL  F+F+G  + +A+   K +D       +K+
Sbjct: 135  PMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKR 194

Query: 4608 LCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSAD--GKMVP 4665
            +     TL+DLE +D    +  NSI+ I+++ + E        L+ +  Q  +  GK+  
Sbjct: 195  MLNKRPTLKDLESID---PEFYNSIVWIKENNLEE------CGLELYFIQDMEILGKVTT 245

Query: 4666 --IIPGGNSIPLTFSNRKEYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQ 4722
              +  GG SI +T  N++EY+    ++R    ++ Q  A  +G + + P+  L     K+
Sbjct: 246  HELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKE 305

Query: 4723 LEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRL 4782
            LE M+CGM EI +   +K   YR   +  + +QWFW  ++E  NE+R+  ++FV+G  RL
Sbjct: 306  LELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRL 365

Query: 4783 PAN------TADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAI 4834
            P         ++  Q+F I KV +    LP S TCF +L LPPY S   + E+L YAI
Sbjct: 366  PVGGFAELIGSNGPQKFCIDKVGKE-TWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422


>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
            isoform 1 [Homo sapiens]
          Length = 870

 Score =  132 bits (332), Expect = 8e-30
 Identities = 104/358 (29%), Positives = 175/358 (48%), Gaps = 32/358 (8%)

Query: 4489 IFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLI 4548
            +F    +Q++ +   DLR   R   + + GE   D GG+  +    +  E+       L 
Sbjct: 524  LFEDSFQQIMNMKPYDLR---RRLYIIMRGEEGLDYGGIAREWFFLLSHEV-------LN 573

Query: 4549 PSPNATAEVGYNRDRFLFNPSACLD-EHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQ 4607
            P        G N      NP++ ++ +HL  F+F+G  + +A+   K +D       +K+
Sbjct: 574  PMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKR 633

Query: 4608 LCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSAD--GKMVP 4665
            +     TL+DLE +D    +  NSI+ I+++ + E        L+ +  Q  +  GK+  
Sbjct: 634  MLNKRPTLKDLESID---PEFYNSIVWIKENNLEE------CGLELYFIQDMEILGKVTT 684

Query: 4666 --IIPGGNSIPLTFSNRKEYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQ 4722
              +  GG SI +T  N++EY+    ++R    ++ Q  A  +G + + P+  L     K+
Sbjct: 685  HELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKE 744

Query: 4723 LEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRL 4782
            LE M+CGM EI +   +K   YR   +  + +QWFW  ++E  NE+R+  ++FV+G  RL
Sbjct: 745  LELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRL 804

Query: 4783 PAN------TADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAI 4834
            P         ++  Q+F I KV +    LP S TCF +L LPPY S   + E+L YAI
Sbjct: 805  PVGGFAELIGSNGPQKFCIDKVGKE-TWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 861


>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
            sapiens]
          Length = 1102

 Score =  132 bits (331), Expect = 1e-29
 Identities = 74/180 (41%), Positives = 103/180 (57%), Gaps = 3/180 (1%)

Query: 4196 NHTLAVSAD-GSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVAL 4254
            N+ L    + G +V+++GDGD+GKLG G S   + PQ I+ L G G+ ++ CG QF +AL
Sbjct: 714  NYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLAL 773

Query: 4255 TKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYA 4314
            TK G V+T+G+     L      +  + Q +  L G  I  VAVGA+H LA+  +G VYA
Sbjct: 774  TKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 833

Query: 4315 WGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 4374
            WG N  GQ G G T   R+P LV GL+G+ +  ++ G  HS AWT   V    P V  P+
Sbjct: 834  WGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDV--ATPSVHEPV 891



 Score =  119 bits (299), Expect = 6e-26
 Identities = 67/155 (43%), Positives = 89/155 (57%), Gaps = 1/155 (0%)

Query: 4101 GEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGN 4160
            G VFSWGDGD+GKLG G S+    P+ IE L G+ V Q+ CG +    +T  G ++T+G 
Sbjct: 725  GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 784

Query: 4161 GDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLG 4220
            GDY RLG  +  + +  + V  L G +I  VA G  H LAV  D   V+A+GD D+G+ G
Sbjct: 785  GDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAV-MDSGQVYAWGDNDHGQQG 843

Query: 4221 LGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALT 4255
             G +T    P  +  L G  I  VACG+  SVA T
Sbjct: 844  NGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 878



 Score =  116 bits (290), Expect = 6e-25
 Identities = 71/184 (38%), Positives = 103/184 (55%), Gaps = 6/184 (3%)

Query: 558 KDISNVGEVSCG--SSHTIALSKD--GRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQG 613
           K + N   +S G  S +   L+K   G  V+S+G GD GKLG G +     P+ IE L G
Sbjct: 698 KSVGNWEYISTGKVSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNG 757

Query: 614 MFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGS-SEATALRPKLIEELAATRIVDVSI 672
             + ++  G+Q  LALT +G V+ WG G     G  S+    + +++E L   +IV V++
Sbjct: 758 QGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAV 817

Query: 673 GDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732
           G  HCLA+    +VYAWG+N  GQ G G +T    KP  V GL+G  I  ++ G+SHS+A
Sbjct: 818 GAQHCLAVMDSGQVYAWGDNDHGQQGNGTTT-VNRKPMLVQGLEGQKIMCVACGSSHSVA 876

Query: 733 WTAL 736
           WT +
Sbjct: 877 WTTM 880



 Score =  111 bits (278), Expect = 2e-23
 Identities = 57/158 (36%), Positives = 97/158 (61%), Gaps = 3/158 (1%)

Query: 4043 QANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGE 4102
            +  G V + G+G +G+LG+G S+  ++   I  L G  V Q+   CG+    +ALT+SG 
Sbjct: 722  EMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQ-FLLALTKSGV 778

Query: 4103 VFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGD 4162
            V++WG GDY +LGH +    R+ + +E L+G+++V ++ G +H   V   G+++ +G+ D
Sbjct: 779  VWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 838

Query: 4163 YGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLA 4200
            +G+ G G T+  + P  V  LEG +I  VACG +H++A
Sbjct: 839  HGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVA 876



 Score =  108 bits (269), Expect = 2e-22
 Identities = 63/167 (37%), Positives = 93/167 (55%), Gaps = 4/167 (2%)

Query: 516 VSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVG--EVSCGSSHT 573
           VS  Y         G +++WG+GDFG+LG G S   NIP  ++ ++  G  ++ CG+   
Sbjct: 711 VSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFL 770

Query: 574 IALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTG 633
           +AL+K G  VW++G GD  +LGH     V K +V+E L+G  I  V  G+Q  LA+  +G
Sbjct: 771 LALTKSG-VVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSG 829

Query: 634 QVYAWGCGACLGCGSSEATALR-PKLIEELAATRIVDVSIGDSHCLA 679
           QVYAWG       G+   T  R P L++ L   +I+ V+ G SH +A
Sbjct: 830 QVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVA 876



 Score = 88.6 bits (218), Expect = 1e-16
 Identities = 50/156 (32%), Positives = 86/156 (55%), Gaps = 6/156 (3%)

Query: 422 GSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481
           G V + G G +G+LG G S   +  + +     + + ++          LA T  G V++
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQ---FLLALTKSGVVWT 781

Query: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFG 541
           WG GDY +LGH +    +  ++++G L+GK +V V+ G +H  AV + G++Y WG+ D G
Sbjct: 782 WGKGDYFRLGHRSDVHVRKLQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHG 840

Query: 542 RLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSHTIA 575
           + G+G +     P LV+ +    +  V+CGSSH++A
Sbjct: 841 QQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVA 876



 Score = 87.4 bits (215), Expect = 3e-16
 Identities = 51/186 (27%), Positives = 93/186 (50%), Gaps = 14/186 (7%)

Query: 3977 DEQIMSW---ATSRPED-WHLGGKCD----VYLWGAGRHGQLAEAGR---NVMVPAAAPS 4025
            D+ + +W   +T +  D + L  KC+    V+ WG G  G+L   G    N+       +
Sbjct: 697  DKSVGNWEYISTGKVSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLN 756

Query: 4026 FSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLV 4085
                 Q+ CG      +  +G V   G+G Y RLG  +   +  L V+  L+G  +  + 
Sbjct: 757  GQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVA 816

Query: 4086 TSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKH 4145
                   H +A+ +SG+V++WGD D+G+ G+G +   R+P  ++ L+G++++ ++CG  H
Sbjct: 817  VGAQ---HCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSH 873

Query: 4146 SAVVTS 4151
            S   T+
Sbjct: 874  SVAWTT 879



 Score = 73.6 bits (179), Expect = 5e-12
 Identities = 50/156 (32%), Positives = 75/156 (48%), Gaps = 6/156 (3%)

Query: 374 VYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT--IEAGQYCTFVISTDGSVRACGKGS 431
           V+ WG     +L  G  E    P+     +      IE G      ++  G V   GKG 
Sbjct: 727 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 786

Query: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491
           Y RLG    ++    K    E  R  K V  + G+  H LA    G+V++WGD D+G+ G
Sbjct: 787 YFRLG--HRSDVHVRKLQVVEGLRGKKIVHVAVGAQ-HCLAVMDSGQVYAWGDNDHGQQG 843

Query: 492 HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
           +G ++  + P L+QG L+G+ ++CV+ G  HS A T
Sbjct: 844 NGTTTVNRKPMLVQG-LEGQKIMCVACGSSHSVAWT 878


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score =  132 bits (331), Expect = 1e-29
 Identities = 87/285 (30%), Positives = 146/285 (51%), Gaps = 22/285 (7%)

Query: 4088 CGSDGHSMALTESGEVFSW-----GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCG 4142
            C  + H   +T   E+++W     G   +G+LGHG+    R+P+ +E LQG+ + Q+SCG
Sbjct: 375  CAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCG 434

Query: 4143 FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKL--PERVTALEGYQIGQVACGLNHTLA 4200
               +  VT +G+L+ FG+  YG +G+   +  ++  P ++       + QV+CG NH + 
Sbjct: 435  DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 494

Query: 4201 VSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHV 4260
            ++ +   V+++G G+YG+LGL +     +PQK+DV   + I  V CG   +  LT+ G V
Sbjct: 495  LTRN-KEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKV 553

Query: 4261 YTFGQDRL--IGLPEGRAR--NHNRPQQIPV---------LAGVIIEDVAVGAEHTLALA 4307
               G +    +GL +  +   NH    ++P          L+   I  +A G  HT A+ 
Sbjct: 554  LACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAID 613

Query: 4308 SNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG-LQGKNVRQISAG 4351
              G +  +G N  GQLG+G+        L+ G L GK V ++S G
Sbjct: 614  ERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCG 658



 Score =  106 bits (264), Expect = 6e-22
 Identities = 91/358 (25%), Positives = 161/358 (44%), Gaps = 45/358 (12%)

Query: 3998 DVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTV-----LACG 4052
            +VY+WG G+                  S   A+QV  G     V+     +     +  G
Sbjct: 348  EVYVWGGGKS--------TPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGG 399

Query: 4053 EGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 4112
               +G+LG G+         +  LQG  + Q+  SCG D  ++ +T+ G+++++G   YG
Sbjct: 400  TKLHGQLGHGDKASYRQPKHVEKLQGKAIRQV--SCGDD-FTVCVTDEGQLYAFGSDYYG 456

Query: 4113 KLGHGNSDRQRRPRQIEALQ-----GEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 4167
             +G    D+   P  +E +Q        V Q+SCG  H  V+T + +++++G G+YGRLG
Sbjct: 457  CMG---VDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLG 513

Query: 4168 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTA- 4226
            L +  +   P++V   +   I  V CG + T  ++  G ++ A G  ++ KLGL    + 
Sbjct: 514  LDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVL-ACGLNEFNKLGLNQCMSG 572

Query: 4227 ------------KSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 4274
                         +S      L    I+ +A G   + A+ + G + TFG ++   L  G
Sbjct: 573  IINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVG 632

Query: 4275 RARNHNRPQQIPVLAGVI----IEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHT 4328
               N+ +   I +L G +    +  V+ G E T+A   +  ++AWG+   G+L +  T
Sbjct: 633  ---NYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPT 687



 Score =  104 bits (259), Expect = 2e-21
 Identities = 103/371 (27%), Positives = 164/371 (44%), Gaps = 49/371 (13%)

Query: 357 PDSIQTGDAPIV---SETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQY 413
           P S    +API    S T EVYVWG   S      T +K+    +  S   A+ + AG  
Sbjct: 329 PRSSTVTEAPIAVVTSRTSEVYVWGGGKS------TPQKL---DVIKSGCSARQVCAGNT 379

Query: 414 CTFVISTDGSVRAC-----GKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG 468
              V++ +  +        G   +G+LG GD  +    K +     ++I++VS     D 
Sbjct: 380 HFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCG---DD 436

Query: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQ-----GKVVVCVSAGYRHS 523
            T+  T EG+++++G   YG +G    +    P++++ P+Q        V  VS G  H 
Sbjct: 437 FTVCVTDEGQLYAFGSDYYGCMGVDKVAG---PEVLE-PMQLNFFLSNPVEQVSCGDNHV 492

Query: 524 AAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN---VGEVSCGSSHTIALSKDG 580
             +T + E+Y+WG G++GRLG         P  V D+     +  V CG   T  L++ G
Sbjct: 493 VVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKV-DVPKALIIVAVQCGCDGTFLLTQSG 551

Query: 581 RTVWSFGGGDNGKLG----------HGDTNRV-YKPKVIEALQGMF--IRKVCAGSQSSL 627
           + V + G  +  KLG          H   + V Y      A Q  F  IR +  G   + 
Sbjct: 552 K-VLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 610

Query: 628 ALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNE 685
           A+   G++  +GC  C  LG G+ +       L   L   +++ VS GD   +A + DN 
Sbjct: 611 AIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNH 670

Query: 686 VYAWGNNSMGQ 696
           ++AWGN   G+
Sbjct: 671 IFAWGNGGNGR 681



 Score =  103 bits (256), Expect = 5e-21
 Identities = 82/300 (27%), Positives = 143/300 (47%), Gaps = 28/300 (9%)

Query: 469 HTLAFTTEGEVFSW-----GDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHS 523
           H    T E E+++W     G   +G+LGHG+ ++ + PK ++  LQGK +  VS G   +
Sbjct: 380 HFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVE-KLQGKAIRQVSCGDDFT 438

Query: 524 AAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVK---DISN-VGEVSCGSSHTIALSKD 579
             VT++G+LY +G   +G +G        +   ++    +SN V +VSCG +H + L+++
Sbjct: 439 VCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRN 498

Query: 580 GRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYA-- 637
            + V+S+G G+ G+LG       Y P+ ++  + + I  V  G   +  LT +G+V A  
Sbjct: 499 -KEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACG 557

Query: 638 ------WGCGACL-GCGSSEATALRP-----KLIEELAATRIVDVSIGDSHCLALSHDNE 685
                  G   C+ G  + EA    P      L ++L+  +I  ++ G +H  A+     
Sbjct: 558 LNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGR 617

Query: 686 VYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAW 745
           +  +G N  GQ G GN    +        L G  + ++S G   ++A T    D  + AW
Sbjct: 618 LLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAAT---DDNHIFAW 674



 Score = 86.3 bits (212), Expect = 7e-16
 Identities = 66/241 (27%), Positives = 105/241 (43%), Gaps = 22/241 (9%)

Query: 358 DSIQTGDAPIV--SETCEVYVWGSNSSHQLVEGTQEKILQPKLA--PSFSDAQTIEAGQY 413
           + +  GD  +V  +   EVY WG     +L   ++E    P+    P       ++ G  
Sbjct: 483 EQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCD 542

Query: 414 CTFVISTDGSVRACGKGSYGRLGL-----GDSNNQSTLK-----KLTFEPHRSIKKVSSS 463
            TF+++  G V ACG   + +LGL     G  N+++  +       T     S  K+ + 
Sbjct: 543 GTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTI 602

Query: 464 KGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHS 523
                HT A    G + ++G    G+LG GN   +    L+ GPL GK V+ VS G   +
Sbjct: 603 APGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFT 662

Query: 524 AAVTEDGELYTWGEGDFGRLG-------HGDSNSRNIP-TLVKDISNVGEVSCGSSHTIA 575
            A T+D  ++ WG G  GRL        HG     + P  +   + +V ++SC   HTI 
Sbjct: 663 IAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTIL 722

Query: 576 L 576
           +
Sbjct: 723 I 723



 Score = 84.7 bits (208), Expect = 2e-15
 Identities = 58/211 (27%), Positives = 98/211 (46%), Gaps = 17/211 (8%)

Query: 523 SAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSH--TIALSKDG 580
           +   +   E+Y WG         G  ++     ++K   +  +V  G++H   + + K+ 
Sbjct: 340 AVVTSRTSEVYVWG---------GGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKEL 390

Query: 581 RTVWSFGGGD--NGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638
            T  +  GG   +G+LGHGD     +PK +E LQG  IR+V  G   ++ +T  GQ+YA+
Sbjct: 391 YTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAF 450

Query: 639 GCG--ACLGCGS-SEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMG 695
           G     C+G    +    L P  +    +  +  VS GD+H + L+ + EVY+WG    G
Sbjct: 451 GSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYG 510

Query: 696 QCGQGNSTGPITKPKKVSGLDGIAIQQISAG 726
           + G  +     T P+KV     + I  +  G
Sbjct: 511 RLGLDSEEDYYT-PQKVDVPKALIIVAVQCG 540



 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 74/311 (23%), Positives = 114/311 (36%), Gaps = 80/311 (25%)

Query: 367 IVSETCEVYVW-----GSNSSHQLVEGTQEKILQPKLAPSFSDA--QTIEAGQYCTFVIS 419
           +V+   E+Y W     G+    QL  G +    QPK          + +  G   T  ++
Sbjct: 383 VVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVT 442

Query: 420 TDGSVRACGKGSYGRLGLGDSNNQSTLK--KLTFEPHRSIKKVSSSKGSDGHTLAFTTEG 477
            +G + A G   YG +G+        L+  +L F     +++VS     D H +  T   
Sbjct: 443 DEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCG---DNHVVVLTRNK 499

Query: 478 EVFSWGDGDYGKLGHGNSSTQKYPKLIQGPL-------------------QGKVVVC--- 515
           EV+SWG G+YG+LG  +      P+ +  P                     GKV+ C   
Sbjct: 500 EVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLN 559

Query: 516 ------------------------------------------VSAGYRHSAAVTEDGELY 533
                                                     ++ G  H+AA+ E G L 
Sbjct: 560 EFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLL 619

Query: 534 TWGEGDFGRLGHGDSNSR---NIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGD 590
           T+G    G+LG G+   R   N+         V  VSCG   TIA + D   ++++G G 
Sbjct: 620 TFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNH-IFAWGNGG 678

Query: 591 NGKLGHGDTNR 601
           NG+L    T R
Sbjct: 679 NGRLAMTPTER 689



 Score = 42.0 bits (97), Expect = 0.015
 Identities = 38/133 (28%), Positives = 60/133 (45%), Gaps = 12/133 (9%)

Query: 4025 SFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGN-SDDLHVLTVISALQGFVVTQ 4083
            SF + + +  G+  T  I   G +L  G    G+LG GN    L +  +   L G  V +
Sbjct: 595  SFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIR 654

Query: 4084 LVTSCGSDGHSMALTESGEVFSWGDGDYGKLG-------HGNSDRQRRPRQIEALQGEEV 4136
            +  SCG D  ++A T+   +F+WG+G  G+L        HG+      PR I       V
Sbjct: 655  V--SCG-DEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG-SLHHV 710

Query: 4137 VQMSCGFKHSAVV 4149
              +SC   H+ ++
Sbjct: 711  PDLSCRGWHTILI 723


>gi|222352183 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  131 bits (330), Expect = 1e-29
 Identities = 99/361 (27%), Positives = 179/361 (49%), Gaps = 23/361 (6%)

Query: 4489 IFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLI 4548
            IF +  R+++ +   D+ L +R W ++   E   D GGV  +    + +E+      L  
Sbjct: 506  IFEESYRRIMSVKRPDV-LKARLW-IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFE 563

Query: 4549 PSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQL 4608
             S      +  N      N   C ++HL  F F+G + G+A+   K LD       +K +
Sbjct: 564  YSATDNYTLQINP-----NSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618

Query: 4609 CCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIP 4668
                +TL D+E VD  Y  +L  IL   ++  TE      I  ++F GQ+     V + P
Sbjct: 619  LGKQITLNDMESVDSEYYNSLKWIL---ENDPTELDLMFCIDEENF-GQT---YQVDLKP 671

Query: 4669 GGNSIPLTFSNRKEYVERAIEYR-LHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMV 4727
             G+ I +T  N++EY++  I++R ++ + +Q+ A  EG + ++P+ L+ +    +LE ++
Sbjct: 672  NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 731

Query: 4728 CGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPAN- 4785
            CG+ ++ V   ++   Y+      H ++QWFW  +     E+R+  ++FV+G SR+P N 
Sbjct: 732  CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791

Query: 4786 -----TADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSI 4840
                  ++  Q F I +   P + LP + TCF +L LPPY +   + E+L  A+ N +  
Sbjct: 792  FAELYGSNGPQLFTIEQWGSP-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850

Query: 4841 D 4841
            +
Sbjct: 851  E 851


>gi|21361472 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score =  131 bits (330), Expect = 1e-29
 Identities = 99/361 (27%), Positives = 179/361 (49%), Gaps = 23/361 (6%)

Query: 4489 IFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLI 4548
            IF +  R+++ +   D+ L +R W ++   E   D GGV  +    + +E+      L  
Sbjct: 607  IFEESYRRIMSVKRPDV-LKARLW-IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFE 664

Query: 4549 PSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQL 4608
             S      +  N      N   C ++HL  F F+G + G+A+   K LD       +K +
Sbjct: 665  YSATDNYTLQINP-----NSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 719

Query: 4609 CCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIP 4668
                +TL D+E VD  Y  +L  IL   ++  TE      I  ++F GQ+     V + P
Sbjct: 720  LGKQITLNDMESVDSEYYNSLKWIL---ENDPTELDLMFCIDEENF-GQT---YQVDLKP 772

Query: 4669 GGNSIPLTFSNRKEYVERAIEYR-LHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMV 4727
             G+ I +T  N++EY++  I++R ++ + +Q+ A  EG + ++P+ L+ +    +LE ++
Sbjct: 773  NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 832

Query: 4728 CGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPAN- 4785
            CG+ ++ V   ++   Y+      H ++QWFW  +     E+R+  ++FV+G SR+P N 
Sbjct: 833  CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 892

Query: 4786 -----TADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSI 4840
                  ++  Q F I +   P + LP + TCF +L LPPY +   + E+L  A+ N +  
Sbjct: 893  FAELYGSNGPQLFTIEQWGSP-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951

Query: 4841 D 4841
            +
Sbjct: 952  E 952


>gi|222352094 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  131 bits (330), Expect = 1e-29
 Identities = 99/361 (27%), Positives = 179/361 (49%), Gaps = 23/361 (6%)

Query: 4489 IFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLI 4548
            IF +  R+++ +   D+ L +R W ++   E   D GGV  +    + +E+      L  
Sbjct: 486  IFEESYRRIMSVKRPDV-LKARLW-IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFE 543

Query: 4549 PSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQL 4608
             S      +  N      N   C ++HL  F F+G + G+A+   K LD       +K +
Sbjct: 544  YSATDNYTLQINP-----NSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 598

Query: 4609 CCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIP 4668
                +TL D+E VD  Y  +L  IL   ++  TE      I  ++F GQ+     V + P
Sbjct: 599  LGKQITLNDMESVDSEYYNSLKWIL---ENDPTELDLMFCIDEENF-GQT---YQVDLKP 651

Query: 4669 GGNSIPLTFSNRKEYVERAIEYR-LHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMV 4727
             G+ I +T  N++EY++  I++R ++ + +Q+ A  EG + ++P+ L+ +    +LE ++
Sbjct: 652  NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 711

Query: 4728 CGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPAN- 4785
            CG+ ++ V   ++   Y+      H ++QWFW  +     E+R+  ++FV+G SR+P N 
Sbjct: 712  CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 771

Query: 4786 -----TADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSI 4840
                  ++  Q F I +   P + LP + TCF +L LPPY +   + E+L  A+ N +  
Sbjct: 772  FAELYGSNGPQLFTIEQWGSP-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830

Query: 4841 D 4841
            +
Sbjct: 831  E 831


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 191,984,817
Number of Sequences: 37866
Number of extensions: 9121227
Number of successful extensions: 51327
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 193
Number of HSP's successfully gapped in prelim test: 410
Number of HSP's that attempted gapping in prelim test: 39293
Number of HSP's gapped (non-prelim): 8769
length of query: 4861
length of database: 18,247,518
effective HSP length: 124
effective length of query: 4737
effective length of database: 13,552,134
effective search space: 64196458758
effective search space used: 64196458758
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 73 (32.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.