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Search of human proteins with 34452695
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34452695 amiloride-sensitive cation channel 1, neuronal
isoform 1 [Homo sapiens]
(563 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo... 1165 0.0
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor... 780 0.0
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo... 598 e-171
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo... 577 e-164
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ... 472 e-133
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ... 472 e-133
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ... 472 e-133
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo... 417 e-116
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo... 391 e-109
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho... 202 7e-52
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi... 154 2e-37
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ... 149 9e-36
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ... 149 9e-36
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H... 149 9e-36
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi... 119 7e-27
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ... 115 1e-25
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1... 115 1e-25
gi|169168451 PREDICTED: hypothetical protein [Homo sapiens] 36 0.11
gi|169168160 PREDICTED: hypothetical protein [Homo sapiens] 36 0.11
gi|169167373 PREDICTED: hypothetical protein [Homo sapiens] 36 0.11
gi|239754305 PREDICTED: hypothetical protein XP_002345935 [Homo ... 35 0.14
gi|239748844 PREDICTED: hypothetical protein XP_002346836 [Homo ... 35 0.14
gi|239742871 PREDICTED: hypothetical protein XP_002342668 [Homo ... 35 0.14
gi|188497630 hypothetical protein LOC55571 [Homo sapiens] 35 0.24
gi|239754110 PREDICTED: hypothetical protein XP_002345881 [Homo ... 34 0.31
gi|239750574 PREDICTED: hypothetical protein [Homo sapiens] 34 0.41
gi|169205732 PREDICTED: hypothetical protein [Homo sapiens] 34 0.41
gi|239755981 PREDICTED: hypothetical protein XP_002344766 [Homo ... 33 0.91
gi|239755873 PREDICTED: hypothetical protein [Homo sapiens] 33 0.91
gi|239750506 PREDICTED: hypothetical protein XP_002347417 [Homo ... 33 0.91
>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
1 [Homo sapiens]
Length = 563
Score = 1165 bits (3015), Expect = 0.0
Identities = 563/563 (100%), Positives = 563/563 (100%)
Query: 1 MSRIGGAGLPAAALTGPGRFRMAREEPAPAALAAAGQPGGGRGGERALQGPGVARRGRPS 60
MSRIGGAGLPAAALTGPGRFRMAREEPAPAALAAAGQPGGGRGGERALQGPGVARRGRPS
Sbjct: 1 MSRIGGAGLPAAALTGPGRFRMAREEPAPAALAAAGQPGGGRGGERALQGPGVARRGRPS 60
Query: 61 LSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRV 120
LSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRV
Sbjct: 61 LSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRV 120
Query: 121 HREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEP 180
HREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEP
Sbjct: 121 HREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEP 180
Query: 181 RRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFTK 240
RRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFTK
Sbjct: 181 RRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFTK 240
Query: 241 YGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIH 300
YGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIH
Sbjct: 241 YGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIH 300
Query: 301 SQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRI 360
SQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRI
Sbjct: 301 SQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRI 360
Query: 361 DCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRY 420
DCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRY
Sbjct: 361 DCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRY 420
Query: 421 NKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALL 480
NKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALL
Sbjct: 421 NKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALL 480
Query: 481 GDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHS 540
GDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHS
Sbjct: 481 GDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHS 540
Query: 541 ETISHTVNVPLQTTLGTLEEIAC 563
ETISHTVNVPLQTTLGTLEEIAC
Sbjct: 541 ETISHTVNVPLQTTLGTLEEIAC 563
>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
[Homo sapiens]
Length = 512
Score = 780 bits (2015), Expect = 0.0
Identities = 397/504 (78%), Positives = 425/504 (84%), Gaps = 23/504 (4%)
Query: 66 LHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRVHREWS 125
LHG+RH+ G RR LW +AF S GLLL SS R+ Y+ S+ T+V +
Sbjct: 26 LHGIRHIFV----YGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVA 81
Query: 126 RQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPN------RTARPLVSELLRGDE 179
+ L FPAVT+CN N RF RL+ DLY+AG L LL N A P V E LR
Sbjct: 82 QSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALR--- 138
Query: 180 PRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFT 239
+ A+F+ + P+ F + F+ R+GH L+DM+L CK++G+ CG +F++VFT
Sbjct: 139 -------QKANFKHY-KPKQFSMLE--FLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFT 188
Query: 240 KYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQI 299
KYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQI
Sbjct: 189 KYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQI 248
Query: 300 HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACR 359
HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACR
Sbjct: 249 HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACR 308
Query: 360 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 419
IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR
Sbjct: 309 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 368
Query: 420 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 479
YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL
Sbjct: 369 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 428
Query: 480 LGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNH 539
LGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNH
Sbjct: 429 LGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNH 488
Query: 540 SETISHTVNVPLQTTLGTLEEIAC 563
SETISHTVNVPLQTTLGTLEEIAC
Sbjct: 489 SETISHTVNVPLQTTLGTLEEIAC 512
>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
b [Homo sapiens]
Length = 528
Score = 598 bits (1543), Expect = e-171
Identities = 307/517 (59%), Positives = 364/517 (70%), Gaps = 26/517 (5%)
Query: 62 SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRVH 121
S + LHGL H+ + + +RALW L F S +LL + R+ Y+ + T++
Sbjct: 23 SSSTLHGLAHIFSYERLS----LKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLD 78
Query: 122 REWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPR 181
+ QL FPAVT+CN N RF ++SK DLY+AG L LL R + + DE +
Sbjct: 79 EVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALL----NNRYEIPDTQMADEKQ 134
Query: 182 RQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFTKY 241
+ + A+FR F P+ F F DR GH + DMLLSC +RGE+C +F VFT+Y
Sbjct: 135 LEILQDKANFRSF-KPKPFN--MREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRY 191
Query: 242 GKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHS 301
GKCY FNSG DG+P L T+KGGTGNGLEIMLDIQQDEYLP+WGET+ET+FEAG+KVQIHS
Sbjct: 192 GKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHS 251
Query: 302 QSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMG--LDFFPVYSITACR 359
Q EPPFI +LGFGVAPGFQTFVA QEQRL YLPPPWG C++ M LDFF YSITACR
Sbjct: 252 QDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACR 311
Query: 360 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 419
IDCETRY+VENCNCRMVHMPGDAP+CTPEQ+KECA+PAL L EKD YC+C PCNLTR
Sbjct: 312 IDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTR 371
Query: 420 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 479
Y KELSMVKIPSK SAKYL KKFNKSE+YI ENILVLDIFFE LNYETIEQKKAYE+A L
Sbjct: 372 YGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431
Query: 480 LGDIGGQMGLFIGASILTILELFDYIYELIKEKLL--DLLGKEEDEGSHDENV------- 530
LGDIGGQMGLFIGASILT+LELFDY YE+IK KL KE S D+ V
Sbjct: 432 LGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDV 491
Query: 531 ---STCDTMPNHSETISHTVNV-PLQTTLGTLEEIAC 563
+ C+++ H +++ N+ P GT E+ C
Sbjct: 492 KRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 528
>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
a [Homo sapiens]
Length = 574
Score = 577 bits (1486), Expect = e-164
Identities = 307/563 (54%), Positives = 364/563 (64%), Gaps = 72/563 (12%)
Query: 62 SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRVH 121
S + LHGL H+ + + +RALW L F S +LL + R+ Y+ + T++
Sbjct: 23 SSSTLHGLAHIFSYERLS----LKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLD 78
Query: 122 REWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPR 181
+ QL FPAVT+CN N RF ++SK DLY+AG L LL R + + DE +
Sbjct: 79 EVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALL----NNRYEIPDTQMADEKQ 134
Query: 182 RQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFTKY 241
+ + A+FR F P+ F F DR GH + DMLLSC +RGE+C +F VFT+Y
Sbjct: 135 LEILQDKANFRSF-KPKPFN--MREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRY 191
Query: 242 GKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHS 301
GKCY FNSG DG+P L T+KGGTGNGLEIMLDIQQDEYLP+WGET+ET+FEAG+KVQIHS
Sbjct: 192 GKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHS 251
Query: 302 QSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMG--LDFFPVYSITACR 359
Q EPPFI +LGFGVAPGFQTFVA QEQRL YLPPPWG C++ M LDFF YSITACR
Sbjct: 252 QDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACR 311
Query: 360 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 419
IDCETRY+VENCNCRMVHMPGDAP+CTPEQ+KECA+PAL L EKD YC+C PCNLTR
Sbjct: 312 IDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTR 371
Query: 420 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 479
Y KELSMVKIPSK SAKYL KKFNKSE+YI ENILVLDIFFE LNYETIEQKKAYE+A L
Sbjct: 372 YGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431
Query: 480 ----------------------------------------------LGDIGGQMGLFIGA 493
LGDIGGQMGLFIGA
Sbjct: 432 LGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGA 491
Query: 494 SILTILELFDYIYELIKEKLL--DLLGKEEDEGSHDENV----------STCDTMPNHSE 541
SILT+LELFDY YE+IK KL KE S D+ V + C+++ H
Sbjct: 492 SILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPA 551
Query: 542 TISHTVNV-PLQTTLGTLEEIAC 563
+++ N+ P GT E+ C
Sbjct: 552 GMTYAANILPHHPARGTFEDFTC 574
>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
sapiens]
Length = 531
Score = 472 bits (1215), Expect = e-133
Identities = 242/515 (46%), Positives = 321/515 (62%), Gaps = 39/515 (7%)
Query: 50 GPGVARRGRPSL----SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSS 105
GP ARR + S +HGL H+ G RR +W A S L +
Sbjct: 6 GPEEARRPASDIRVFASNCSMHGLGHVFG----PGSLSLRRGMWAAAVVLSVATFLYQVA 61
Query: 106 NRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNR 165
R+ Y+ F T + S +L FPAVT+CN NPLR RL+ DL++AG L L P
Sbjct: 62 ERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAE 121
Query: 166 TARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYR 225
A + L R P F+P F+ A R GH L+DMLL C++R
Sbjct: 122 HAA-FLRALGRPPAPPG-----------FMPSPTFD--MAQLYARAGHSLDDMLLDCRFR 167
Query: 226 GELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGE 285
G+ CGP NF+++FT+ GKCY FNSG DG LLTT +GG GNGL+IMLD+QQ+EYLP+W +
Sbjct: 168 GQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRD 227
Query: 286 TEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEM 345
EET FE G++VQIHSQ EPP I +LG GV+PG+QTFV+ Q+Q+L++LPPPWG+C S+ +
Sbjct: 228 NEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASL 287
Query: 346 GLDF---------------FPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQH 390
++ P Y++ CR+ CETRY+ C CRMV+MPGD P C+P+Q+
Sbjct: 288 NPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQY 347
Query: 391 KECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYIS 450
K CA PA+ + KDS C C PC TRY KELSMV+IPS+ +A++L +K N+SE YI+
Sbjct: 348 KNCAHPAIDAMLRKDS--CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIA 405
Query: 451 ENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIK 510
EN+L LDIFFEALNYET+EQKKAYE++ LLGDIGGQMGLFIGAS+LTILE+ DY+ E+ +
Sbjct: 406 ENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFR 465
Query: 511 EKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISH 545
+K+L + H + + +H + H
Sbjct: 466 DKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPH 500
>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
sapiens]
Length = 549
Score = 472 bits (1215), Expect = e-133
Identities = 242/515 (46%), Positives = 321/515 (62%), Gaps = 39/515 (7%)
Query: 50 GPGVARRGRPSL----SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSS 105
GP ARR + S +HGL H+ G RR +W A S L +
Sbjct: 6 GPEEARRPASDIRVFASNCSMHGLGHVFG----PGSLSLRRGMWAAAVVLSVATFLYQVA 61
Query: 106 NRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNR 165
R+ Y+ F T + S +L FPAVT+CN NPLR RL+ DL++AG L L P
Sbjct: 62 ERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAE 121
Query: 166 TARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYR 225
A + L R P F+P F+ A R GH L+DMLL C++R
Sbjct: 122 HAA-FLRALGRPPAPPG-----------FMPSPTFD--MAQLYARAGHSLDDMLLDCRFR 167
Query: 226 GELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGE 285
G+ CGP NF+++FT+ GKCY FNSG DG LLTT +GG GNGL+IMLD+QQ+EYLP+W +
Sbjct: 168 GQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRD 227
Query: 286 TEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEM 345
EET FE G++VQIHSQ EPP I +LG GV+PG+QTFV+ Q+Q+L++LPPPWG+C S+ +
Sbjct: 228 NEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASL 287
Query: 346 GLDF---------------FPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQH 390
++ P Y++ CR+ CETRY+ C CRMV+MPGD P C+P+Q+
Sbjct: 288 NPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQY 347
Query: 391 KECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYIS 450
K CA PA+ + KDS C C PC TRY KELSMV+IPS+ +A++L +K N+SE YI+
Sbjct: 348 KNCAHPAIDAMLRKDS--CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIA 405
Query: 451 ENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIK 510
EN+L LDIFFEALNYET+EQKKAYE++ LLGDIGGQMGLFIGAS+LTILE+ DY+ E+ +
Sbjct: 406 ENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFR 465
Query: 511 EKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISH 545
+K+L + H + + +H + H
Sbjct: 466 DKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPH 500
>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
sapiens]
Length = 543
Score = 472 bits (1214), Expect = e-133
Identities = 242/514 (47%), Positives = 325/514 (63%), Gaps = 40/514 (7%)
Query: 50 GPGVARRGRPSL----SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSS 105
GP ARR + S +HGL H+ G RR +W A S L +
Sbjct: 6 GPEEARRPASDIRVFASNCSMHGLGHVFG----PGSLSLRRGMWAAAVVLSVATFLYQVA 61
Query: 106 NRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNR 165
R+ Y+ F T + S +L FPAVT+CN NPLR RL+ DL++AG L L P
Sbjct: 62 ERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAE 121
Query: 166 TARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYR 225
A + L R P F+P F+ A R GH L+DMLL C++R
Sbjct: 122 HAA-FLRALGRPPAPPG-----------FMPSPTFD--MAQLYARAGHSLDDMLLDCRFR 167
Query: 226 GELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGE 285
G+ CGP NF+++FT+ GKCY FNSG DG LLTT +GG GNGL+IMLD+QQ+EYLP+W +
Sbjct: 168 GQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRD 227
Query: 286 TEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEM 345
EET FE G++VQIHSQ EPP I +LG GV+PG+QTFV+ Q+Q+L++LPPPWG+C S+ +
Sbjct: 228 NEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASL 287
Query: 346 GLDF---------------FPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQH 390
++ P Y++ CR+ CETRY+ C CRMV+MPGD P C+P+Q+
Sbjct: 288 NPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQY 347
Query: 391 KECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYIS 450
K CA PA+ + KDS C C PC TRY KELSMV+IPS+ +A++L +K N+SE YI+
Sbjct: 348 KNCAHPAIDAMLRKDS--CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIA 405
Query: 451 ENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIK 510
EN+L LDIFFEALNYET+EQKKAYE++ LLGDIGGQMGLFIGAS+LTILE+ DY+ E+ +
Sbjct: 406 ENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFR 465
Query: 511 EKLLDLLGKEEDEGSHDE-NVSTCDTMPNHSETI 543
+K+L + H N+++ ++ H +++
Sbjct: 466 DKVLGYFWNRQHSQRHSSTNLTSHPSLCRHQDSL 499
>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
sapiens]
Length = 666
Score = 417 bits (1071), Expect = e-116
Identities = 229/480 (47%), Positives = 295/480 (61%), Gaps = 39/480 (8%)
Query: 43 GGERALQG---PGVARRGRPSL-SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFG 98
G E++L G PG A R + S + LHGL C G RR LW LA TS
Sbjct: 151 GDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACG----PGPHGLRRTLWALALLTSLA 206
Query: 99 LLLSWSSNRLLYWLSFPSHTRVHREWSRQLP-FPAVTVCNNNPLRFPRLSKGDLYYAGHW 157
L ++ +L+ P + + FPAVT+CN N R LS D+++ +
Sbjct: 207 AFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANL 266
Query: 158 LGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLED 217
GL +R LR EP + D ++R GHQL D
Sbjct: 267 TGLPPKDRDGHRAAG--LRYPEP------DMVD----------------ILNRTGHQLAD 302
Query: 218 MLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQD 277
ML SC + G C NFS V+T+YGKCY FN+ D + L + GG G+GLEIMLDIQQ+
Sbjct: 303 MLKSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQE 360
Query: 278 EYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPW 337
EYLPIW ET ET+FEAG++VQIHSQ EPP+I +LGFGV+PGFQTFV+ QEQRLTYLP PW
Sbjct: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420
Query: 338 GECRSS----EMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKEC 393
G CR+ E L + YS++ACR+ CE +++ C+CRMVHMPG+ C P + EC
Sbjct: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIEC 480
Query: 394 AEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENI 453
A+ L L C C TPCNLTRY KE+SMV+IP++ SA+YL +K+N++E YI EN
Sbjct: 481 ADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 540
Query: 454 LVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKL 513
LVLD+FFEAL E +EQ+ AY ++ALLGD+GGQMGLFIGASILT+LE+ DYIYE+ ++L
Sbjct: 541 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 600
>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
sapiens]
Length = 647
Score = 391 bits (1005), Expect = e-109
Identities = 222/480 (46%), Positives = 285/480 (59%), Gaps = 58/480 (12%)
Query: 43 GGERALQG---PGVARRGRPSL-SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFG 98
G E++L G PG A R + S + LHGL C G RR LW LA TS
Sbjct: 151 GDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACG----PGPHGLRRTLWALALLTSLA 206
Query: 99 LLLSWSSNRLLYWLSFPSHTRVHREWSRQLP-FPAVTVCNNNPLRFPRLSKGDLYYAGHW 157
L ++ +L+ P + + FPAVT+CN N R LS D+++ +
Sbjct: 207 AFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANL 266
Query: 158 LGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLED 217
GL +R LR EP + D ++R GHQL D
Sbjct: 267 TGLPPKDRDGHRAAG--LRYPEP------DMVD----------------ILNRTGHQLAD 302
Query: 218 MLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQD 277
ML SC + G C NFS V+T+YGKCY FN+ D + L + GG G+GLEIMLDIQQ+
Sbjct: 303 MLKSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQE 360
Query: 278 EYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPW 337
EYLPIW ET ET+FEAG++VQIHSQ EPP+I +LGFGV+PGFQTFV+ QEQRLTYLP PW
Sbjct: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420
Query: 338 GECRSS----EMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKEC 393
G CR+ E L + YS++ACR+ CE +++ C+CRMVHMP
Sbjct: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPDS------------ 468
Query: 394 AEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENI 453
L C C TPCNLTRY KE+SMV+IP++ SA+YL +K+N++E YI EN
Sbjct: 469 -------LGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 521
Query: 454 LVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKL 513
LVLD+FFEAL E +EQ+ AY ++ALLGD+GGQMGLFIGASILT+LE+ DYIYE+ ++L
Sbjct: 522 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 581
>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
sapiens]
Length = 505
Score = 202 bits (514), Expect = 7e-52
Identities = 134/453 (29%), Positives = 222/453 (49%), Gaps = 45/453 (9%)
Query: 67 HGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRVHREWSR 126
HG+ ++ R+ RR LW++ S L+ RLL + ++P+ T + ++
Sbjct: 48 HGIHNIVQNRSKI-----RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVE 102
Query: 127 QLPFPAVTVCNNNPLRFPRLSK-GDLYYAGHWLGLLLPNRTARPLVSELLRGDE--PRRQ 183
++ FPAVT CN N + ++K G +++ H +VS++L E
Sbjct: 103 KMEFPAVTFCNLNRFQTDAVAKFGVIFFLWH-------------IVSKVLHLQEITANST 149
Query: 184 WFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDM-LLSCKYRGELCGPHNFSSVFTKYG 242
R+ DF H F+ G L + LL C++ G+ C P +F+ VFT+YG
Sbjct: 150 GSREATDFAA----SHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYG 205
Query: 243 KCYMFNSGE--DGKPLLTTVKGGTGNGLEIMLDIQQDEYL--PIWGETEETTFEAGVKVQ 298
C+ FN GE K ++ +G GL ++ ++ Q+ + P G + AG+
Sbjct: 206 NCFTFNHGETLQAKRKVSV----SGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFV 256
Query: 299 IHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITAC 358
IHS + P LG G V ++ + + PWGEC + + L F YS + C
Sbjct: 257 IHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPN-IKLQNFSSYSTSGC 315
Query: 359 RIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKD-----SNYCLCRT 413
+C+ ++I + C C +PG C +++ C P L + KD ++ C
Sbjct: 316 LKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPV 375
Query: 414 PCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKA 473
C Y +S PS+ + KYL KK N+S KYI EN++ ++I + LNY+ +Q+KA
Sbjct: 376 SCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKA 435
Query: 474 YEVAALLGDIGGQMGLFIGASILTILELFDYIY 506
V+ LL D+GGQ+GLF GAS++TI+E+ +Y++
Sbjct: 436 VSVSELLADLGGQLGLFCGASLITIIEIIEYLF 468
>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
sapiens]
Length = 640
Score = 154 bits (389), Expect = 2e-37
Identities = 100/356 (28%), Positives = 171/356 (48%), Gaps = 26/356 (7%)
Query: 216 EDMLLSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDI 274
E M+L+C + E C NF+S+F YG CY+FN G K L + GT GL+++LDI
Sbjct: 243 EQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKAL-PSANPGTEFGLKLILDI 301
Query: 275 QQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLP 334
Q++Y+P T AGV++ +H Q PFI++ G G +T + +L +
Sbjct: 302 GQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMG 355
Query: 335 PPWGEC--RSSEMGL-----DFFPVYSITACRIDCETRYIVENCNCR--MVHMPGDAPFC 385
P+ C SE+ + D+ YSI AC C +++ NCNC + +P +C
Sbjct: 356 EPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYC 415
Query: 386 TPEQHKECAEPALGL---LAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYL---- 438
+ A L +A++++ +C+ CN T+Y +SM PS+ S ++
Sbjct: 416 NNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVL 475
Query: 439 --EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASIL 496
E+ + + + I+ L+I+F+ NY TIE+ A + LL ++GGQ G ++G S+L
Sbjct: 476 SQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVL 535
Query: 497 TILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQ 552
++E + I + + ++ L+ + S P +E + N Q
Sbjct: 536 CLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQ 591
>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
[Homo sapiens]
Length = 728
Score = 149 bits (375), Expect = 9e-36
Identities = 118/512 (23%), Positives = 220/512 (42%), Gaps = 88/512 (17%)
Query: 85 RRALWVLAFCTSFGLLLSWSSNRLL-YWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRF 143
+ A W + + +FG++ W L + S+P ++ S +L FPAVT+C NP R+
Sbjct: 142 KTAFWAVLWLCTFGMMY-WQFGLLFGEYFSYPVSLNINLN-SDKLVFPAVTICTLNPYRY 199
Query: 144 PRLSKG-------------DLYYAGHWLGLLLPNRTARPL-------------------- 170
P + + DLY + L+ +R+ R L
Sbjct: 200 PEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGA 259
Query: 171 -----VSELLRGDEPRRQWFRKLADFRLFLPPR---------------------HFEGIS 204
V+ LR + P+ W F+L + H+ I
Sbjct: 260 RRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL 319
Query: 205 AAFMDRLGHQLEDML----LSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTT 259
+ + L ED L +C++ C N+S YG CY FN + +++
Sbjct: 320 SRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSS 379
Query: 260 VKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGF 319
+ G NGL +ML +Q++++P+ G +V +H Q EP F+ + GF + PG
Sbjct: 380 MPG-INNGLSLMLRAEQNDFIPLLSTV------TGARVMVHGQDEPAFMDDGGFNLRPGV 432
Query: 320 QTFVATQEQRLTYLPPPWGECRSSEMGL---DFFPV-YSITACRIDCETRYIVENCNCRM 375
+T ++ +++ L L +G+C + + + +P Y+ C C +++ C C
Sbjct: 433 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAY 492
Query: 376 VHMPG--DAPFCTPEQHKECAEPALGLLAEKDSNY--CL--CRTPCNLTRYNKELSMVKI 429
+ P + +C +H L + S++ C CR PC++T Y +
Sbjct: 493 IFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRW 552
Query: 430 PSKTSAKYLEKKFNKSEKYISEN----ILVLDIFFEALNYETIEQKKAYEVAALLGDIGG 485
PS TS +++ + ++ Y N + ++IFF+ LNY+T + + + LL ++G
Sbjct: 553 PSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGS 612
Query: 486 QMGLFIGASILTILELFDYIYELIKEKLLDLL 517
Q L+ G+S+L+++E+ + +++L+ L LL
Sbjct: 613 QWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 644
>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
[Homo sapiens]
Length = 692
Score = 149 bits (375), Expect = 9e-36
Identities = 118/512 (23%), Positives = 220/512 (42%), Gaps = 88/512 (17%)
Query: 85 RRALWVLAFCTSFGLLLSWSSNRLL-YWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRF 143
+ A W + + +FG++ W L + S+P ++ S +L FPAVT+C NP R+
Sbjct: 106 KTAFWAVLWLCTFGMMY-WQFGLLFGEYFSYPVSLNINLN-SDKLVFPAVTICTLNPYRY 163
Query: 144 PRLSKG-------------DLYYAGHWLGLLLPNRTARPL-------------------- 170
P + + DLY + L+ +R+ R L
Sbjct: 164 PEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGA 223
Query: 171 -----VSELLRGDEPRRQWFRKLADFRLFLPPR---------------------HFEGIS 204
V+ LR + P+ W F+L + H+ I
Sbjct: 224 RRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL 283
Query: 205 AAFMDRLGHQLEDML----LSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTT 259
+ + L ED L +C++ C N+S YG CY FN + +++
Sbjct: 284 SRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSS 343
Query: 260 VKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGF 319
+ G NGL +ML +Q++++P+ G +V +H Q EP F+ + GF + PG
Sbjct: 344 MPG-INNGLSLMLRAEQNDFIPLLSTV------TGARVMVHGQDEPAFMDDGGFNLRPGV 396
Query: 320 QTFVATQEQRLTYLPPPWGECRSSEMGL---DFFPV-YSITACRIDCETRYIVENCNCRM 375
+T ++ +++ L L +G+C + + + +P Y+ C C +++ C C
Sbjct: 397 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAY 456
Query: 376 VHMPG--DAPFCTPEQHKECAEPALGLLAEKDSNY--CL--CRTPCNLTRYNKELSMVKI 429
+ P + +C +H L + S++ C CR PC++T Y +
Sbjct: 457 IFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRW 516
Query: 430 PSKTSAKYLEKKFNKSEKYISEN----ILVLDIFFEALNYETIEQKKAYEVAALLGDIGG 485
PS TS +++ + ++ Y N + ++IFF+ LNY+T + + + LL ++G
Sbjct: 517 PSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGS 576
Query: 486 QMGLFIGASILTILELFDYIYELIKEKLLDLL 517
Q L+ G+S+L+++E+ + +++L+ L LL
Sbjct: 577 QWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 608
>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
sapiens]
Length = 669
Score = 149 bits (375), Expect = 9e-36
Identities = 118/512 (23%), Positives = 220/512 (42%), Gaps = 88/512 (17%)
Query: 85 RRALWVLAFCTSFGLLLSWSSNRLL-YWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRF 143
+ A W + + +FG++ W L + S+P ++ S +L FPAVT+C NP R+
Sbjct: 83 KTAFWAVLWLCTFGMMY-WQFGLLFGEYFSYPVSLNINLN-SDKLVFPAVTICTLNPYRY 140
Query: 144 PRLSKG-------------DLYYAGHWLGLLLPNRTARPL-------------------- 170
P + + DLY + L+ +R+ R L
Sbjct: 141 PEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGA 200
Query: 171 -----VSELLRGDEPRRQWFRKLADFRLFLPPR---------------------HFEGIS 204
V+ LR + P+ W F+L + H+ I
Sbjct: 201 RRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL 260
Query: 205 AAFMDRLGHQLEDML----LSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTT 259
+ + L ED L +C++ C N+S YG CY FN + +++
Sbjct: 261 SRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSS 320
Query: 260 VKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGF 319
+ G NGL +ML +Q++++P+ G +V +H Q EP F+ + GF + PG
Sbjct: 321 MPG-INNGLSLMLRAEQNDFIPLLSTV------TGARVMVHGQDEPAFMDDGGFNLRPGV 373
Query: 320 QTFVATQEQRLTYLPPPWGECRSSEMGL---DFFPV-YSITACRIDCETRYIVENCNCRM 375
+T ++ +++ L L +G+C + + + +P Y+ C C +++ C C
Sbjct: 374 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAY 433
Query: 376 VHMPG--DAPFCTPEQHKECAEPALGLLAEKDSNY--CL--CRTPCNLTRYNKELSMVKI 429
+ P + +C +H L + S++ C CR PC++T Y +
Sbjct: 434 IFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRW 493
Query: 430 PSKTSAKYLEKKFNKSEKYISEN----ILVLDIFFEALNYETIEQKKAYEVAALLGDIGG 485
PS TS +++ + ++ Y N + ++IFF+ LNY+T + + + LL ++G
Sbjct: 494 PSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGS 553
Query: 486 QMGLFIGASILTILELFDYIYELIKEKLLDLL 517
Q L+ G+S+L+++E+ + +++L+ L LL
Sbjct: 554 QWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 585
>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
sapiens]
Length = 649
Score = 119 bits (298), Expect = 7e-27
Identities = 83/321 (25%), Positives = 147/321 (45%), Gaps = 40/321 (12%)
Query: 211 LGHQLEDMLLSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLE 269
+ + E++L++C + G C NF+ +G CY FN+ E+ + +L+T GG+ GL+
Sbjct: 249 MSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNREN-ETILSTSMGGSEYGLQ 307
Query: 270 IMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQR 329
++L I ++EY P G KV IH Q E PF++++G + T +
Sbjct: 308 VILYINEEEYNPF------LVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTE 361
Query: 330 LTYLPPPWGECRSSEMGLD------FFPVYSITACRIDCETRYIVENCNCRMVH--MPGD 381
L P+ +C +E G D + YS+ C C +VE C C +P
Sbjct: 362 SFKLSEPYSQC--TEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPA 419
Query: 382 APFCTPEQHKECA----EPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKY 437
A +C +QH + + E+ +C+ C+ + S+ + PS S K+
Sbjct: 420 ANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKW 479
Query: 438 L------------EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGG 485
L KK NK++ + L IF++ LN +I + A + LL + GG
Sbjct: 480 LLPVLTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANSIEMLLSNFGG 533
Query: 486 QMGLFIGASILTILELFDYIY 506
Q+GL++ S++ ++E+ + +
Sbjct: 534 QLGLWMSCSVVCVIEIIEVFF 554
Score = 38.5 bits (88), Expect = 0.017
Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 8/95 (8%)
Query: 49 QGPGVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRL 108
Q P + R HG R + R RR LW+ T+ L+L W L
Sbjct: 21 QAPTIKELMRWYCLNTNTHGCRRIVVSRGRL-----RRLLWIGFTLTAVALIL-WQCALL 74
Query: 109 LYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRF 143
++ SF + + + R+L FPAVT+CN NP ++
Sbjct: 75 VF--SFYTVSVSIKVHFRKLDFPAVTICNINPYKY 107
>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
[Homo sapiens]
Length = 638
Score = 115 bits (288), Expect = 1e-25
Identities = 79/321 (24%), Positives = 147/321 (45%), Gaps = 28/321 (8%)
Query: 203 ISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTTVK 261
+ AA+ D G Q +LSC Y G C F + YG CY + + T +
Sbjct: 244 LPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDG------VWTAQR 297
Query: 262 GGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQT 321
G +G+ ++L ++Q +LP+ AG++V +H ++ PF+ F V PG +
Sbjct: 298 PGITHGVGLVLRVEQQPHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEA 351
Query: 322 FVATQEQRLTYLPPPWGECRSSEMGLDFFPV----YSITACRIDCETRYIVENCNCRM-V 376
++ +E + L P+G C + G++ + Y+ AC + C + +VE C+C +
Sbjct: 352 TISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYL 411
Query: 377 H-MPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRT----PCNLTRYNKELSMVKIPS 431
H +P A +C+ +H L + +++ C + PC + + + PS
Sbjct: 412 HPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPS 471
Query: 432 KTSAKYL-----EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQ 486
SA + E+ ++ ++I ++ LNY ++E+ Y V LL +G
Sbjct: 472 AKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSL 531
Query: 487 MGLFIGASILTILELFDYIYE 507
L+ GAS+L++LEL + + +
Sbjct: 532 CSLWFGASVLSLLELLELLLD 552
>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
[Homo sapiens]
Length = 704
Score = 115 bits (288), Expect = 1e-25
Identities = 79/321 (24%), Positives = 147/321 (45%), Gaps = 28/321 (8%)
Query: 203 ISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTTVK 261
+ AA+ D G Q +LSC Y G C F + YG CY + + T +
Sbjct: 310 LPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDG------VWTAQR 363
Query: 262 GGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQT 321
G +G+ ++L ++Q +LP+ AG++V +H ++ PF+ F V PG +
Sbjct: 364 PGITHGVGLVLRVEQQPHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEA 417
Query: 322 FVATQEQRLTYLPPPWGECRSSEMGLDFFPV----YSITACRIDCETRYIVENCNCRM-V 376
++ +E + L P+G C + G++ + Y+ AC + C + +VE C+C +
Sbjct: 418 TISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYL 477
Query: 377 H-MPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRT----PCNLTRYNKELSMVKIPS 431
H +P A +C+ +H L + +++ C + PC + + + PS
Sbjct: 478 HPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPS 537
Query: 432 KTSAKYL-----EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQ 486
SA + E+ ++ ++I ++ LNY ++E+ Y V LL +G
Sbjct: 538 AKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSL 597
Query: 487 MGLFIGASILTILELFDYIYE 507
L+ GAS+L++LEL + + +
Sbjct: 598 CSLWFGASVLSLLELLELLLD 618
>gi|169168451 PREDICTED: hypothetical protein [Homo sapiens]
Length = 148
Score = 35.8 bits (81), Expect = 0.11
Identities = 26/62 (41%), Positives = 31/62 (50%), Gaps = 16/62 (25%)
Query: 15 TGPGRFRMA-REEPAPA--------------ALAAAGQP-GGGRGGERALQGPGVARRGR 58
TGPG FR A R++P PA A AG+P GGGRG Q P + +R R
Sbjct: 23 TGPGAFRKASRQDPRPAWGGGGGSPFLRNQVKQAVAGRPLGGGRGQGCTAQVPPLLQRPR 82
Query: 59 PS 60
PS
Sbjct: 83 PS 84
>gi|169168160 PREDICTED: hypothetical protein [Homo sapiens]
Length = 148
Score = 35.8 bits (81), Expect = 0.11
Identities = 26/62 (41%), Positives = 31/62 (50%), Gaps = 16/62 (25%)
Query: 15 TGPGRFRMA-REEPAPA--------------ALAAAGQP-GGGRGGERALQGPGVARRGR 58
TGPG FR A R++P PA A AG+P GGGRG Q P + +R R
Sbjct: 23 TGPGAFRKASRQDPRPAWGGGGGSPFLRNQVKQAVAGRPLGGGRGQGCTAQVPPLLQRPR 82
Query: 59 PS 60
PS
Sbjct: 83 PS 84
>gi|169167373 PREDICTED: hypothetical protein [Homo sapiens]
Length = 148
Score = 35.8 bits (81), Expect = 0.11
Identities = 26/62 (41%), Positives = 31/62 (50%), Gaps = 16/62 (25%)
Query: 15 TGPGRFRMA-REEPAPA--------------ALAAAGQP-GGGRGGERALQGPGVARRGR 58
TGPG FR A R++P PA A AG+P GGGRG Q P + +R R
Sbjct: 23 TGPGAFRKASRQDPRPAWGGGGGSPFLRNQVKQAVAGRPLGGGRGQGCTAQVPPLLQRPR 82
Query: 59 PS 60
PS
Sbjct: 83 PS 84
>gi|239754305 PREDICTED: hypothetical protein XP_002345935 [Homo
sapiens]
Length = 156
Score = 35.4 bits (80), Expect = 0.14
Identities = 23/55 (41%), Positives = 27/55 (49%)
Query: 6 GAGLPAAALTGPGRFRMAREEPAPAALAAAGQPGGGRGGERALQGPGVARRGRPS 60
GAG A PG +A AA+AAAG G GR G + PG+A GR S
Sbjct: 97 GAGAGAVPKAMPGAVAVAVAAGGVAAVAAAGAEGRGRVGGQLRALPGLAAGGRAS 151
>gi|239748844 PREDICTED: hypothetical protein XP_002346836 [Homo
sapiens]
Length = 156
Score = 35.4 bits (80), Expect = 0.14
Identities = 23/55 (41%), Positives = 27/55 (49%)
Query: 6 GAGLPAAALTGPGRFRMAREEPAPAALAAAGQPGGGRGGERALQGPGVARRGRPS 60
GAG A PG +A AA+AAAG G GR G + PG+A GR S
Sbjct: 97 GAGAGAVPKAMPGAVAVAVAAGGVAAVAAAGAEGRGRVGGQLRALPGLAAGGRAS 151
>gi|239742871 PREDICTED: hypothetical protein XP_002342668 [Homo
sapiens]
Length = 156
Score = 35.4 bits (80), Expect = 0.14
Identities = 23/55 (41%), Positives = 27/55 (49%)
Query: 6 GAGLPAAALTGPGRFRMAREEPAPAALAAAGQPGGGRGGERALQGPGVARRGRPS 60
GAG A PG +A AA+AAAG G GR G + PG+A GR S
Sbjct: 97 GAGAGAVPKAMPGAVAVAVAAGGVAAVAAAGAEGRGRVGGQLRALPGLAAGGRAS 151
>gi|188497630 hypothetical protein LOC55571 [Homo sapiens]
Length = 510
Score = 34.7 bits (78), Expect = 0.24
Identities = 26/84 (30%), Positives = 36/84 (42%), Gaps = 5/84 (5%)
Query: 5 GGAGLPAAALTGPGRFRMAREEPAPAALAAAGQPGGGRGGE----RALQGPGVARRGRPS 60
GGA + L R +RE A+ + G GGGRGG GPG GR S
Sbjct: 4 GGASAASGRLLTAAEQRGSREAAGSASRSGFGGSGGGRGGASGPGSGSGGPG-GPAGRMS 62
Query: 61 LSRAKLHGLRHMCAGRTAAGGSFQ 84
L+ +L L + + G +F+
Sbjct: 63 LTPKELSSLLSIISEEAGGGSTFE 86
>gi|239754110 PREDICTED: hypothetical protein XP_002345881 [Homo
sapiens]
Length = 284
Score = 34.3 bits (77), Expect = 0.31
Identities = 29/74 (39%), Positives = 34/74 (45%), Gaps = 8/74 (10%)
Query: 5 GGAGLPAAALT-----GPGRFRMAREEPAPAALAAAGQPGGGRGGER-ALQGPGVARRGR 58
G A LPAAA T GPG A + + A G GGG GG R + +G G RG
Sbjct: 140 GAATLPAAAATTTALDGPGAGGGAERGGSGRSSAGGGGGGGGGGGGRGSRRGRGGGERGG 199
Query: 59 PSLS--RAKLHGLR 70
P R +L LR
Sbjct: 200 PRAQAVRRRLSALR 213
>gi|239750574 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1297
Score = 33.9 bits (76), Expect = 0.41
Identities = 32/96 (33%), Positives = 35/96 (36%), Gaps = 16/96 (16%)
Query: 5 GGAGLPAAALTGP-----------GRFRMAREEPAPAALAAAGQPGGGR--GGERALQGP 51
GGA AA GP R R R A+AAAG+ G G GG R G
Sbjct: 826 GGARGGGAAAGGPLAGAVVQRMRQRRVRAGRRRVGARAVAAAGRQGAGAGGGGRRVRHGH 885
Query: 52 GVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRA 87
G G L RA RH+ AA R A
Sbjct: 886 G---HGAAVLQRAPCRQQRHLAPAAAAAAAQGVRAA 918
>gi|169205732 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1297
Score = 33.9 bits (76), Expect = 0.41
Identities = 32/96 (33%), Positives = 35/96 (36%), Gaps = 16/96 (16%)
Query: 5 GGAGLPAAALTGP-----------GRFRMAREEPAPAALAAAGQPGGGR--GGERALQGP 51
GGA AA GP R R R A+AAAG+ G G GG R G
Sbjct: 826 GGARGGGAAAGGPLAGAVVQRMRQRRVRAGRRRVGARAVAAAGRQGAGAGGGGRRVRHGH 885
Query: 52 GVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRA 87
G G L RA RH+ AA R A
Sbjct: 886 G---HGAAVLQRAPCRQQRHLAPAAAAAAAQGVRAA 918
>gi|239755981 PREDICTED: hypothetical protein XP_002344766 [Homo
sapiens]
Length = 307
Score = 32.7 bits (73), Expect = 0.91
Identities = 23/58 (39%), Positives = 29/58 (50%), Gaps = 7/58 (12%)
Query: 6 GAGLPAAALTGPGRFRMA---REEPAPAALAAAGQPGGGRGGERALQGPGVARRGRPS 60
G GLP+AA P R + R +PA ++AG G R + L GPG GRPS
Sbjct: 115 GPGLPSAAAARPARKTLTCQPRSIESPATASSAGCGSGPRVPQVRLLGPG----GRPS 168
>gi|239755873 PREDICTED: hypothetical protein [Homo sapiens]
Length = 577
Score = 32.7 bits (73), Expect = 0.91
Identities = 25/74 (33%), Positives = 29/74 (39%), Gaps = 9/74 (12%)
Query: 6 GAGL--------PAAALTG-PGRFRMAREEPAPAALAAAGQPGGGRGGERALQGPGVARR 56
GAGL PA AL G P R R P A Q G G +++ QGP
Sbjct: 277 GAGLRSKIWQLGPAGALRGRPRRKRYPEAGRVPGARVQEPQRGAGEQKDQSAQGPAAQPH 336
Query: 57 GRPSLSRAKLHGLR 70
RP + K G R
Sbjct: 337 PRPGILMLKTFGCR 350
>gi|239750506 PREDICTED: hypothetical protein XP_002347417 [Homo
sapiens]
Length = 325
Score = 32.7 bits (73), Expect = 0.91
Identities = 23/58 (39%), Positives = 29/58 (50%), Gaps = 7/58 (12%)
Query: 6 GAGLPAAALTGPGRFRMA---REEPAPAALAAAGQPGGGRGGERALQGPGVARRGRPS 60
G GLP+AA P R + R +PA ++AG G R + L GPG GRPS
Sbjct: 133 GPGLPSAAAARPARKTLTCQPRSIESPATASSAGCGSGPRVPQVRLLGPG----GRPS 186
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,441,966
Number of Sequences: 37866
Number of extensions: 1244251
Number of successful extensions: 4636
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 4460
Number of HSP's gapped (non-prelim): 164
length of query: 563
length of database: 18,247,518
effective HSP length: 107
effective length of query: 456
effective length of database: 14,195,856
effective search space: 6473310336
effective search space used: 6473310336
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.