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Search of human proteins with 33350928
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33350928 disabled homolog 1 [Homo sapiens]
(555 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33350928 disabled homolog 1 [Homo sapiens] 1119 0.0
gi|148491082 disabled homolog 2 [Homo sapiens] 231 2e-60
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom... 77 4e-14
gi|54144629 numb homolog isoform 4 [Homo sapiens] 65 2e-10
gi|54144627 numb homolog isoform 2 [Homo sapiens] 63 6e-10
gi|132626790 low density lipoprotein receptor adaptor protein 1 ... 62 2e-09
gi|4508017 zinc finger protein 207 isoform a [Homo sapiens] 61 3e-09
gi|20070356 numb homolog isoform 3 [Homo sapiens] 57 3e-08
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens] 57 3e-08
gi|150170670 piccolo isoform 2 [Homo sapiens] 57 4e-08
gi|150378539 piccolo isoform 1 [Homo sapiens] 57 4e-08
gi|148612835 zinc finger protein 207 isoform c [Homo sapiens] 56 1e-07
gi|54144625 numb homolog isoform 1 [Homo sapiens] 55 1e-07
gi|10863899 numb homolog (Drosophila)-like [Homo sapiens] 54 3e-07
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s... 54 4e-07
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 54 4e-07
gi|222418647 mucin 7, secreted precursor [Homo sapiens] 54 5e-07
gi|222418649 mucin 7, secreted precursor [Homo sapiens] 54 5e-07
gi|222418645 mucin 7, secreted precursor [Homo sapiens] 54 5e-07
gi|50511947 cajalin 2 isoform b [Homo sapiens] 51 2e-06
gi|50511945 cajalin 2 isoform a [Homo sapiens] 51 2e-06
gi|10047134 cajalin 2 isoform c [Homo sapiens] 51 2e-06
gi|26051278 nuclear pore membrane protein 121 [Homo sapiens] 50 7e-06
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 49 1e-05
gi|73808090 zinc finger protein 207 isoform b [Homo sapiens] 48 2e-05
gi|222352122 hypothetical protein LOC284297 [Homo sapiens] 47 5e-05
gi|239743232 PREDICTED: hypothetical protein XP_002342775 [Homo ... 47 5e-05
gi|163965366 nascent polypeptide-associated complex alpha subuni... 47 5e-05
gi|47132519 Ras association and pleckstrin homology domains 1 is... 47 6e-05
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho... 47 6e-05
>gi|33350928 disabled homolog 1 [Homo sapiens]
Length = 555
Score = 1119 bits (2895), Expect = 0.0
Identities = 555/555 (100%), Positives = 555/555 (100%)
Query: 1 MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKL 60
MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKL
Sbjct: 1 MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKL 60
Query: 61 CQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDI 120
CQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDI
Sbjct: 61 CQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDI 120
Query: 121 TDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQC 180
TDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQC
Sbjct: 121 TDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQC 180
Query: 181 EQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPV 240
EQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPV
Sbjct: 181 EQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPV 240
Query: 241 SAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGY 300
SAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGY
Sbjct: 241 SAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGY 300
Query: 301 VAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQ 360
VAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQ
Sbjct: 301 VAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQ 360
Query: 361 FPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQM 420
FPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQM
Sbjct: 361 FPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQM 420
Query: 421 AQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTN 480
AQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTN
Sbjct: 421 AQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTN 480
Query: 481 SPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEP 540
SPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEP
Sbjct: 481 SPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEP 540
Query: 541 SGEPSGDNISPQAGS 555
SGEPSGDNISPQAGS
Sbjct: 541 SGEPSGDNISPQAGS 555
>gi|148491082 disabled homolog 2 [Homo sapiens]
Length = 770
Score = 231 bits (588), Expect = 2e-60
Identities = 175/550 (31%), Positives = 258/550 (46%), Gaps = 97/550 (17%)
Query: 4 ETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQD 63
+ + Q A K +KK+ +KKG ++++ L+ RFKG+GV+YKAKLIGID+V ARGDK+ QD
Sbjct: 13 QPDQQAAPKAPSKKE-KKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQD 71
Query: 64 SMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDH 123
SMMKLKG+ A RS+G+HKQ+I++ IS GIKI DEKTG ++H H V++IS+IA+D+TD+
Sbjct: 72 SMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDN 131
Query: 124 RAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQA 183
RAFGYVCG EG H+F AIKT Q AEP+++DL+DLFQ+IY +K++EE +KK + + +A
Sbjct: 132 RAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIE---EASKA 188
Query: 184 VYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSAV 243
V E G E + + D ++ S V
Sbjct: 189 V-------------------ENGSEALM-------------------ILDDQTNKLKSGV 210
Query: 244 TQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAM 303
Q++LFGDMSTPPD+ S P D + + + + + PF T + S +
Sbjct: 211 DQMDLFGDMSTPPDLNS---PTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPR 267
Query: 304 GAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPP 363
SF + A + P P P+ T Q P
Sbjct: 268 PTPQASFLPENAF------------------SANLNFFPTPNPDPFRDDPF-TQPDQSTP 308
Query: 364 AAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQP 423
++F ++ TPL+ P D Q D+ + GK Q AQ
Sbjct: 309 SSFDSLKS-PDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGK------QEAQA 361
Query: 424 PPVP-SRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQL--------NLTPVTS 474
P P S QP++ + N V + L +L
Sbjct: 362 GPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQ 421
Query: 475 TTPSTNSPPTPAPRQSSPS---KSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQAS 531
++P + P P+ + P +++ S A+D DIF AP S+ S
Sbjct: 422 SSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIF--------------APPVSEPS 467
Query: 532 SNSDPFGEPS 541
+ P G+P+
Sbjct: 468 GQASPTGQPT 477
Score = 102 bits (254), Expect = 9e-22
Identities = 109/333 (32%), Positives = 140/333 (42%), Gaps = 70/333 (21%)
Query: 257 DITSPPTPATPGDAFIPSSSQTL-PASADVFSSVPFGTAAVPSG-YVAMGAVLPSFWGQQ 314
DI +PP G A L P D+F + +A P G V +G V +
Sbjct: 457 DIFAPPVSEPSGQASPTGQPTALQPNPLDLFKT----SAPAPVGPLVGLGGVTVTLPQAG 512
Query: 315 PLVQQQMVMGAQPPVAQ-VMPGAQPIAWGQPGLF---PATQ---QPWPTVAGQFPPAAFM 367
P +V P +A M G QP + QP +F PA QP P A PP +
Sbjct: 513 PWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTPPPVPVV 572
Query: 368 --------------------PTQT-VMPLPAAMFQGP-------LTPLATVPG------- 392
P Q+ + P PA Q P +TP P
Sbjct: 573 WGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRAGPPKDI 632
Query: 393 TSDS-TRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFN-KV 450
+SD+ T P DK + + KE FKDFQ+ QPP VP+RK +Q S + T AF+SYFN KV
Sbjct: 633 SSDAFTALDPLGDKEIKDV-KEMFKDFQLRQPPAVPARKGEQTS-SGTLSAFASYFNSKV 690
Query: 451 GVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFE 510
G+ Q+ D DDFD +QL N PP PAPRQ S + +TD+ FE
Sbjct: 691 GIPQENADHDDFDANQL--------LNKINEPPKPAPRQVSLPVTK-------STDNAFE 735
Query: 511 EGFESPSKSEEQEAPDGSQASSNS---DPFGEP 540
F S Q + SQ S+ DPFG P
Sbjct: 736 NPFFKDSFGSSQASVASSQPVSSEMYRDPFGNP 768
>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
sapiens]
Length = 304
Score = 77.0 bits (188), Expect = 4e-14
Identities = 71/277 (25%), Positives = 119/277 (42%), Gaps = 27/277 (9%)
Query: 19 SRKKGQD--RSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGAR 76
SRKK + + L K F + Y AK +G EV +G ++ +D++ KLK +
Sbjct: 6 SRKKDKTWMHTPEALSKHF----IPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKK 61
Query: 77 SKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVC--GKEG 134
S+G+ K+ L IS G+KI + KT +QH+ +H IS+ A D TD R F ++C +
Sbjct: 62 SEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESN 121
Query: 135 NHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVE 194
H + + AE + L + F L Y R+ LE KD + + + L++ ++
Sbjct: 122 KHLCYVFDSEKCAEEITLTIGQAFDLAY----RKFLE-SGGKDVETRKQI--AGLQKRIQ 174
Query: 195 DPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMST 254
D + + + ++D E + I QV P ++F +
Sbjct: 175 DLETENMELK---NKVQDLENQLRITQVSAP---------PAGSMTPKSPSTDIFDMIPF 222
Query: 255 PPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPF 291
P P G P S++ D+F + PF
Sbjct: 223 SPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPF 259
>gi|54144629 numb homolog isoform 4 [Homo sapiens]
Length = 592
Score = 65.1 bits (157), Expect = 2e-10
Identities = 115/542 (21%), Positives = 198/542 (36%), Gaps = 85/542 (15%)
Query: 38 EGVR-----YKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFG 92
EGVR + K +G EV +RG +C+D++ +LK G+ K L +S
Sbjct: 30 EGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAT-------GKKAVKAVLWVSAD 82
Query: 93 GIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGN------HRFVAIKTAQA 146
G+++ DEKT L + ++S+ A D RAF Y+C ++G H F+A+K
Sbjct: 83 GLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYIC-RDGTTRRWICHCFMAVK---- 137
Query: 147 AEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAG 206
D + LE+K +++K+C F+A
Sbjct: 138 ------DTGERLSHAVGCAFAACLERKQKREKECGVTA-----------------TFDAS 174
Query: 207 HEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPAT 266
R T E ++V T+ ++ ++ K + + + S+ + P+P++
Sbjct: 175 ----RTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSS 230
Query: 267 PGDAFIPSSSQTLPASADVFSSVPFGTAAVPS--------GYVAMGAVLPSFWGQQPLVQ 318
P P+S T + ++P A + G+ A+ + F Q L
Sbjct: 231 PTS---PTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRI 287
Query: 319 QQMVMGAQP----PVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMP 374
++ Q P+ +P + A L + T F A TV+
Sbjct: 288 NELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVA 347
Query: 375 LPAAMFQGP---LTPLATVPGTSDS--TRSSPQTDKPRQKMGKETFKDFQMAQPPPV-PS 428
+ FQG + A PG + R+ + D+ +++ K A P+ P
Sbjct: 348 PQSPTFQGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPV 407
Query: 429 RKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPR 488
+P P T S+ S + + Q P S P N P PAP
Sbjct: 408 LQPPPP--TAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSY-PVANGMPYPAPN 464
Query: 489 QS----SPSKSSAS---HASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPS 541
+PS+ A+ A P +SPS +Q P +S+ + PF +P
Sbjct: 465 VPVVGITPSQMVANVFGTAGHPQA----AHPHQSPSLVRQQTFPHYEASSATTSPFFKPP 520
Query: 542 GE 543
+
Sbjct: 521 AQ 522
>gi|54144627 numb homolog isoform 2 [Homo sapiens]
Length = 603
Score = 63.2 bits (152), Expect = 6e-10
Identities = 117/546 (21%), Positives = 200/546 (36%), Gaps = 82/546 (15%)
Query: 38 EGVR-----YKAKLIGIDEVSAARGDKLCQDSMMKLKG---VVAGARSK-GEHKQKIFLT 88
EGVR + K +G EV +RG +C+D++ +LK G K G+ K L
Sbjct: 30 EGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLW 89
Query: 89 ISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGN------HRFVAIK 142
+S G+++ DEKT L + ++S+ A D RAF Y+C ++G H F+A+K
Sbjct: 90 VSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYIC-RDGTTRRWICHCFMAVK 148
Query: 143 TAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIV 202
D + LE+K +++K+C
Sbjct: 149 ----------DTGERLSHAVGCAFAACLERKQKREKECGVTA-----------------T 181
Query: 203 FEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPP 262
F+A R T E ++V T+ ++ ++ K + + + S+ + P
Sbjct: 182 FDAS----RTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAP 237
Query: 263 TPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPS--------GYVAMGAVLPSFWGQQ 314
+P++P P+S T + ++P A + G+ A+ + F Q
Sbjct: 238 SPSSPTS---PTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQL 294
Query: 315 PLVQQQMVMGAQP----PVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQ 370
L ++ Q P+ +P + A L + T F A
Sbjct: 295 SLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPV 354
Query: 371 TVMPLPAAMFQGP---LTPLATVPGTSDS--TRSSPQTDKPRQKMGKETFKDFQMAQPPP 425
TV+ + FQG + A PG + R+ + D+ +++ K A P
Sbjct: 355 TVVAPQSPTFQGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAP 414
Query: 426 V-PSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPT 484
+ P +P P T S+ S + + Q P S P N P
Sbjct: 415 LQPVLQPPPP--TAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSY-PVANGMPY 471
Query: 485 PAPRQS----SPSKSSAS---HASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPF 537
PAP +PS+ A+ A P +SPS +Q P +S+ + PF
Sbjct: 472 PAPNVPVVGITPSQMVANVFGTAGHPQA----AHPHQSPSLVRQQTFPHYEASSATTSPF 527
Query: 538 GEPSGE 543
+P +
Sbjct: 528 FKPPAQ 533
>gi|132626790 low density lipoprotein receptor adaptor protein 1
[Homo sapiens]
Length = 308
Score = 61.6 bits (148), Expect = 2e-09
Identities = 42/150 (28%), Positives = 77/150 (51%), Gaps = 10/150 (6%)
Query: 38 EGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIF 97
EG+ + K +G+ V +G++L S +K +VA A++ G+ QK+ L +S GI +
Sbjct: 44 EGMLFSLKYLGMTLVEQPKGEEL---SAAAIKRIVATAKASGKKLQKVTLKVSPRGIILT 100
Query: 98 DEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGN-----HRFVAIKTAQAAEPVIL 152
D T L + +++ ISY D + F Y+ + N H F+ K + A+ V L
Sbjct: 101 DNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTK-RKMAQAVTL 159
Query: 153 DLRDLFQLIYELKQREELEKKAQKDKQCEQ 182
+ F++ +E Q + E+K ++DK ++
Sbjct: 160 TVAQAFKVAFEFWQVSK-EEKEKRDKASQE 188
>gi|4508017 zinc finger protein 207 isoform a [Homo sapiens]
Length = 478
Score = 60.8 bits (146), Expect = 3e-09
Identities = 72/305 (23%), Positives = 114/305 (37%), Gaps = 52/305 (17%)
Query: 261 PPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQ 320
PP P PG P +P + +P +P G + MG ++P G PL+
Sbjct: 148 PPVPGAPG--MPPGIPPLMPGVPPLMPGMPPVMPGMPPGMMPMGGMMPPGPGIPPLM-PG 204
Query: 321 MVMGAQPPVAQVMPGAQPIAWGQ----PGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLP 376
M G PPV + PG P+ Q PG+ P TV PP T+ + P
Sbjct: 205 MPPGMPPPVPR--PGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPV----TKPLFP-S 257
Query: 377 AAMFQGPLTPLATVPGTSDSTRSS-----PQTDKPRQKMGKETFKDFQMAQPPPVPSRKP 431
A P+T +T S+S +S P T + + + DF+ P + +P
Sbjct: 258 AGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEP 317
Query: 432 DQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPA--PRQ 489
+P+ +++ +S TSTT ST + P + +
Sbjct: 318 PKPTFPAYTQSTAS--------------------------TTSTTNSTAAKPAASITSKP 351
Query: 490 SSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNI 549
++ + +SA+ +DI E + ++ P QA P G P P G +
Sbjct: 352 ATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQA-----PIGNPPVGPIGGMM 406
Query: 550 SPQAG 554
PQ G
Sbjct: 407 PPQPG 411
Score = 31.6 bits (70), Expect = 2.0
Identities = 33/127 (25%), Positives = 51/127 (40%), Gaps = 15/127 (11%)
Query: 253 STPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYV-AMGAVLPSFW 311
STP T PP P P A+ S++ T +S TAA P+ + + A L +
Sbjct: 309 STPATTTEPPKPTFP--AYTQSTAST--------TSTTNSTAAKPAASITSKPATLTTTS 358
Query: 312 GQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQT 371
L+ + + AQ+ + + +PG P P + G PP +P Q
Sbjct: 359 ATSKLIHPDEDISLEERRAQLPKYQRNLP--RPGQAPIGNPPVGPIGGMMPPQPGIPQQQ 416
Query: 372 VM--PLP 376
M P+P
Sbjct: 417 GMRPPMP 423
>gi|20070356 numb homolog isoform 3 [Homo sapiens]
Length = 640
Score = 57.4 bits (137), Expect = 3e-08
Identities = 44/145 (30%), Positives = 69/145 (47%), Gaps = 21/145 (14%)
Query: 38 EGVR-----YKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFG 92
EGVR + K +G EV +RG +C+D++ +LK G+ K L +S
Sbjct: 30 EGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAT-------GKKAVKAVLWVSAD 82
Query: 93 GIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGN------HRFVAIKTAQA 146
G+++ DEKT L + ++S+ A D RAF Y+C ++G H F+A+K
Sbjct: 83 GLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYIC-RDGTTRRWICHCFMAVK--DT 139
Query: 147 AEPVILDLRDLFQLIYELKQREELE 171
E + + F E KQ+ E E
Sbjct: 140 GERLSHAVGCAFAACLERKQKREKE 164
>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
Length = 788
Score = 57.4 bits (137), Expect = 3e-08
Identities = 83/335 (24%), Positives = 123/335 (36%), Gaps = 40/335 (11%)
Query: 164 LKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVP 223
+K + +++ Q+ +Q Q + Q L++ + Q + + + + I Q P
Sbjct: 221 IKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQ------QQQQQALQAQPPIQQPP 274
Query: 224 TSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLP--A 281
Q + P SQ + Q PP P A + +P SQT P +
Sbjct: 275 MQQPQP-----PPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVS 329
Query: 282 SADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAW 341
A T P +V V+ QQP VQ Q+ Q Q AQ +A
Sbjct: 330 QAQALPGQMLYTQP-PLKFVRAPMVV-----QQPPVQPQVQQ--QQTAVQTAQAAQMVAP 381
Query: 342 GQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSP 401
G + A Q + +FPP T V +P++ P+A V +S SSP
Sbjct: 382 GVQMITEALAQGGMHIRARFPP-----TTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSP 436
Query: 402 QTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDD 461
+ Q Q PPP PS +P QPS S S G A
Sbjct: 437 SPGQQVQTP--------QSMPPPPQPSPQPGQPSSQPNSNVSS------GPAPSPSSFLP 482
Query: 462 FDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSS 496
Q + +PVT+ TP S P+P P + + SS
Sbjct: 483 SPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSS 517
Score = 42.7 bits (99), Expect = 9e-04
Identities = 62/273 (22%), Positives = 97/273 (35%), Gaps = 55/273 (20%)
Query: 314 QPLVQQQMVMGAQPPVAQVMPGA------------------QPIAWGQPGLFPATQQPWP 355
QP +QQ + QPP +Q +P P+A QP P Q P
Sbjct: 267 QPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQP 326
Query: 356 TVA-GQFPPAAFMPTQTVMPL---PAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMG 411
V+ Q P + TQ + P + Q P+ P T+ T + Q P +M
Sbjct: 327 LVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMI 386
Query: 412 KETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTP 471
E M + +R P +++ + S + +AQ +SQ +L
Sbjct: 387 TEALAQGGMH----IRARFPPTTAVSAIPSS-SIPLGRQPMAQ---------VSQSSLPM 432
Query: 472 VTSTTP--------STNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQE 523
++S +P S PP P+P+ PS S+ S SPS
Sbjct: 433 LSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA--------PSPSSFLPSP 484
Query: 524 APDGSQA---SSNSDPFGEPSGEPSGDNISPQA 553
+P SQ+ + F PS P ++P +
Sbjct: 485 SPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSS 517
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 57.0 bits (136), Expect = 4e-08
Identities = 110/465 (23%), Positives = 165/465 (35%), Gaps = 93/465 (20%)
Query: 138 FVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPV 197
F++ A +A +++ + F LI + + +E K QK Q EQ + I++ ++
Sbjct: 156 FLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQP 215
Query: 198 YQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKS--QPVSAVTQ--------LE 247
+ I + G P RDP ++ + +SQ+ E + P +P+ TQ L
Sbjct: 216 PKPIPKQQG--PGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLP 273
Query: 248 LFGDMSTP--------------PDITSP-------PTPATPGDAFIPSSSQTLPASADVF 286
L D S P P + SP PTP P A P ++ P
Sbjct: 274 LQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKP-PAQQPGHEKSQPG----- 327
Query: 287 SSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGL 346
P A PSG A P +P VQ G P AQ + A+P A
Sbjct: 328 ---PAKPPAQPSGLTKPLAQQPGT--VKPPVQPP---GTTKPPAQPLGPAKPPAQQTGSE 379
Query: 347 FPATQQPWPTVAGQFPPAAFMPTQTVMPL-PAAMFQGPLTPLATVPGTSDSTRSSPQTDK 405
P+++QP P Q P P Q P P G PLA PG ++ T
Sbjct: 380 KPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKT 439
Query: 406 PRQK------------MGKETFKDFQMAQPP---PVPSRKPDQPSLTCTSEAFSSYFNKV 450
P Q+ GK + + +PP P P++ P Q +
Sbjct: 440 PVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQ---------------QP 484
Query: 451 GVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFE 510
G A+ Q S P + PP P + PS P+ +
Sbjct: 485 GPAKPPP-------QQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ----Q 533
Query: 511 EGFESPSKSEEQEAPDGSQASSNSDPFGEP-SGEP-SGDNISPQA 553
G P S +Q +P A ++ P + SG+P +SP A
Sbjct: 534 PGSAKP--SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSA 576
Score = 37.4 bits (85), Expect = 0.036
Identities = 91/383 (23%), Positives = 128/383 (33%), Gaps = 87/383 (22%)
Query: 230 GVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSS---QTLPASADVF 286
GV P QP A + G TP + P +P A P+ + Q P
Sbjct: 396 GVGKTPAQQPGPAKPPTQQVG---TPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQ 452
Query: 287 SSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGL 346
+ P T+A +G + LP A+PP Q P P QPG
Sbjct: 453 QAGPGKTSAQQTGPTKPPSQLPG--------------PAKPPPQQPGPAKPPPQ--QPGS 496
Query: 347 F-PATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDK 405
P +QQP T PP P Q P+ G P + PG++ + P K
Sbjct: 497 AKPPSQQPGSTK----PP----PQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548
Query: 406 PRQKMGKETFKDFQMAQP--PPVPSRKPDQP----------SLTCTSEAF-----SSYFN 448
P + + +P PP S QP L T+E + FN
Sbjct: 549 PSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFN 608
Query: 449 KVGVAQDTD---------------------DCDDFDISQLNLTPVTS-----------TT 476
Q T +C +L PV S TT
Sbjct: 609 TCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTT 668
Query: 477 PSTNSPPTPAPRQSSPSKSSA-----SHASDP-TTDDIFEEGFESPSKSEEQEAPDGSQA 530
S S +P P+Q+SP K +A S A +P + ++ S S + + P + +
Sbjct: 669 TSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADS 728
Query: 531 SSNSDPFGEPSGEPSGDNISPQA 553
S P EPS PS + +P A
Sbjct: 729 LSKPAPPKEPS-VPSEQDKAPVA 750
Score = 32.7 bits (73), Expect = 0.89
Identities = 77/344 (22%), Positives = 119/344 (34%), Gaps = 61/344 (17%)
Query: 235 PKSQPVSAVTQLELFGDMSTPPDITSP--PTPATPGDAFIPSSSQTLPASADVFSSVPFG 292
P QP SA + G PP P P+P PG PS P SA + P
Sbjct: 490 PPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQ---PGSAKPSAQQP-- 544
Query: 293 TAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGA---------------- 336
+ A PS + V + G+ PL + A+ P +Q +P
Sbjct: 545 SPAKPSAQQSTKPVSQTGSGK-PLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPE 603
Query: 337 ----------QPIAWGQPGLFPATQ----QPWPTVAGQFPPAAFMPTQTVMPLPAAMFQG 382
Q G P + W + Q A + P+P++
Sbjct: 604 KANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRAL---GGDLAPVPSS---- 656
Query: 383 PLTPLATVPGTSDS--TRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTS 440
P L T P T+ S ++SSPQ + K +D A P P QP+L +
Sbjct: 657 PQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP 716
Query: 441 EAFSSYFNKV-GVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASH 499
A + + +++ + S+ + PV P P+ P+ S
Sbjct: 717 SAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPK-------QPKMVKPTTDLVSS 769
Query: 500 ASDPTTDDIFEEGFESPSKSEEQEAP----DGSQASSNSDPFGE 539
+S T DI + S++EE+ P D ++ S + P GE
Sbjct: 770 SSATTKPDI--PSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGE 811
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 57.0 bits (136), Expect = 4e-08
Identities = 110/465 (23%), Positives = 165/465 (35%), Gaps = 93/465 (20%)
Query: 138 FVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPV 197
F++ A +A +++ + F LI + + +E K QK Q EQ + I++ ++
Sbjct: 156 FLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQP 215
Query: 198 YQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKS--QPVSAVTQ--------LE 247
+ I + G P RDP ++ + +SQ+ E + P +P+ TQ L
Sbjct: 216 PKPIPKQQG--PGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLP 273
Query: 248 LFGDMSTP--------------PDITSP-------PTPATPGDAFIPSSSQTLPASADVF 286
L D S P P + SP PTP P A P ++ P
Sbjct: 274 LQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKP-PAQQPGHEKSQPG----- 327
Query: 287 SSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGL 346
P A PSG A P +P VQ G P AQ + A+P A
Sbjct: 328 ---PAKPPAQPSGLTKPLAQQPGT--VKPPVQPP---GTTKPPAQPLGPAKPPAQQTGSE 379
Query: 347 FPATQQPWPTVAGQFPPAAFMPTQTVMPL-PAAMFQGPLTPLATVPGTSDSTRSSPQTDK 405
P+++QP P Q P P Q P P G PLA PG ++ T
Sbjct: 380 KPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKT 439
Query: 406 PRQK------------MGKETFKDFQMAQPP---PVPSRKPDQPSLTCTSEAFSSYFNKV 450
P Q+ GK + + +PP P P++ P Q +
Sbjct: 440 PVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQ---------------QP 484
Query: 451 GVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFE 510
G A+ Q S P + PP P + PS P+ +
Sbjct: 485 GPAKPPP-------QQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ----Q 533
Query: 511 EGFESPSKSEEQEAPDGSQASSNSDPFGEP-SGEP-SGDNISPQA 553
G P S +Q +P A ++ P + SG+P +SP A
Sbjct: 534 PGSAKP--SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSA 576
Score = 37.4 bits (85), Expect = 0.036
Identities = 91/383 (23%), Positives = 128/383 (33%), Gaps = 87/383 (22%)
Query: 230 GVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSS---QTLPASADVF 286
GV P QP A + G TP + P +P A P+ + Q P
Sbjct: 396 GVGKTPAQQPGPAKPPTQQVG---TPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQ 452
Query: 287 SSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGL 346
+ P T+A +G + LP A+PP Q P P QPG
Sbjct: 453 QAGPGKTSAQQTGPTKPPSQLPG--------------PAKPPPQQPGPAKPPPQ--QPGS 496
Query: 347 F-PATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDK 405
P +QQP T PP P Q P+ G P + PG++ + P K
Sbjct: 497 AKPPSQQPGSTK----PP----PQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548
Query: 406 PRQKMGKETFKDFQMAQP--PPVPSRKPDQP----------SLTCTSEAF-----SSYFN 448
P + + +P PP S QP L T+E + FN
Sbjct: 549 PSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFN 608
Query: 449 KVGVAQDTD---------------------DCDDFDISQLNLTPVTS-----------TT 476
Q T +C +L PV S TT
Sbjct: 609 TCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTT 668
Query: 477 PSTNSPPTPAPRQSSPSKSSA-----SHASDP-TTDDIFEEGFESPSKSEEQEAPDGSQA 530
S S +P P+Q+SP K +A S A +P + ++ S S + + P + +
Sbjct: 669 TSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADS 728
Query: 531 SSNSDPFGEPSGEPSGDNISPQA 553
S P EPS PS + +P A
Sbjct: 729 LSKPAPPKEPS-VPSEQDKAPVA 750
Score = 32.7 bits (73), Expect = 0.89
Identities = 77/344 (22%), Positives = 119/344 (34%), Gaps = 61/344 (17%)
Query: 235 PKSQPVSAVTQLELFGDMSTPPDITSP--PTPATPGDAFIPSSSQTLPASADVFSSVPFG 292
P QP SA + G PP P P+P PG PS P SA + P
Sbjct: 490 PPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQ---PGSAKPSAQQP-- 544
Query: 293 TAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGA---------------- 336
+ A PS + V + G+ PL + A+ P +Q +P
Sbjct: 545 SPAKPSAQQSTKPVSQTGSGK-PLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPE 603
Query: 337 ----------QPIAWGQPGLFPATQ----QPWPTVAGQFPPAAFMPTQTVMPLPAAMFQG 382
Q G P + W + Q A + P+P++
Sbjct: 604 KANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRAL---GGDLAPVPSS---- 656
Query: 383 PLTPLATVPGTSDS--TRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTS 440
P L T P T+ S ++SSPQ + K +D A P P QP+L +
Sbjct: 657 PQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP 716
Query: 441 EAFSSYFNKV-GVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASH 499
A + + +++ + S+ + PV P P+ P+ S
Sbjct: 717 SAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPK-------QPKMVKPTTDLVSS 769
Query: 500 ASDPTTDDIFEEGFESPSKSEEQEAP----DGSQASSNSDPFGE 539
+S T DI + S++EE+ P D ++ S + P GE
Sbjct: 770 SSATTKPDI--PSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGE 811
>gi|148612835 zinc finger protein 207 isoform c [Homo sapiens]
Length = 494
Score = 55.8 bits (133), Expect = 1e-07
Identities = 76/317 (23%), Positives = 114/317 (35%), Gaps = 60/317 (18%)
Query: 261 PPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQ 320
PP P PG P +P + +P +P G SF G+ ++
Sbjct: 148 PPVPGAPG--MPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMG 205
Query: 321 MVMGAQPPVAQVMPG---AQPIAWGQPGLFPATQQPWPTVAG--QFPPAAFMPTQTVMPL 375
+M P + +MPG P +PG+ P TQ + G PPA PT TV P
Sbjct: 206 GMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPA---PTATV-PA 261
Query: 376 PAAMFQGPLTPLA---TVPGTSDSTRSS-------------PQTDKPRQKMGKETFKDFQ 419
P PL P A P TS ST SS P T + + + DF+
Sbjct: 262 PQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFK 321
Query: 420 MAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPST 479
P + +P +P+ +++ +S TSTT ST
Sbjct: 322 PLNSTPATTTEPPKPTFPAYTQSTAS--------------------------TTSTTNST 355
Query: 480 NSPPTPA--PRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPF 537
+ P + + ++ + +SA+ +DI E + ++ P QA P
Sbjct: 356 AAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQA-----PI 410
Query: 538 GEPSGEPSGDNISPQAG 554
G P P G + PQ G
Sbjct: 411 GNPPVGPIGGMMPPQPG 427
Score = 31.6 bits (70), Expect = 2.0
Identities = 33/127 (25%), Positives = 51/127 (40%), Gaps = 15/127 (11%)
Query: 253 STPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYV-AMGAVLPSFW 311
STP T PP P P A+ S++ T +S TAA P+ + + A L +
Sbjct: 325 STPATTTEPPKPTFP--AYTQSTAST--------TSTTNSTAAKPAASITSKPATLTTTS 374
Query: 312 GQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQT 371
L+ + + AQ+ + + +PG P P + G PP +P Q
Sbjct: 375 ATSKLIHPDEDISLEERRAQLPKYQRNLP--RPGQAPIGNPPVGPIGGMMPPQPGIPQQQ 432
Query: 372 VM--PLP 376
M P+P
Sbjct: 433 GMRPPMP 439
>gi|54144625 numb homolog isoform 1 [Homo sapiens]
Length = 651
Score = 55.5 bits (132), Expect = 1e-07
Identities = 46/149 (30%), Positives = 71/149 (47%), Gaps = 18/149 (12%)
Query: 38 EGVR-----YKAKLIGIDEVSAARGDKLCQDSMMKLKG---VVAGARSK-GEHKQKIFLT 88
EGVR + K +G EV +RG +C+D++ +LK G K G+ K L
Sbjct: 30 EGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLW 89
Query: 89 ISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGN------HRFVAIK 142
+S G+++ DEKT L + ++S+ A D RAF Y+C ++G H F+A+K
Sbjct: 90 VSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYIC-RDGTTRRWICHCFMAVK 148
Query: 143 TAQAAEPVILDLRDLFQLIYELKQREELE 171
E + + F E KQ+ E E
Sbjct: 149 --DTGERLSHAVGCAFAACLERKQKREKE 175
>gi|10863899 numb homolog (Drosophila)-like [Homo sapiens]
Length = 609
Score = 54.3 bits (129), Expect = 3e-07
Identities = 39/136 (28%), Positives = 66/136 (48%), Gaps = 16/136 (11%)
Query: 42 YKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKT 101
+ + +G EV +RG +C+D++ KLK + G K L +S G+++ D+KT
Sbjct: 80 FPVRYLGHVEVEESRGMHVCEDAVKKLKAM-------GRKSVKSVLWVSADGLRVVDDKT 132
Query: 102 GALQHHHAVHEISYIAKDITDHRAFGYVCGKEGN------HRFVAIKTAQAAEPVILDLR 155
L + ++S+ A D +AF Y+C ++G H F+A+K + E + +
Sbjct: 133 KDLLVDQTIEKVSFCAPDRNLDKAFSYIC-RDGTTRRWICHCFLALK--DSGERLSHAVG 189
Query: 156 DLFQLIYELKQREELE 171
F E KQR E E
Sbjct: 190 CAFAACLERKQRREKE 205
>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
sapiens]
Length = 4911
Score = 53.9 bits (128), Expect = 4e-07
Identities = 77/355 (21%), Positives = 128/355 (36%), Gaps = 45/355 (12%)
Query: 223 PTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPAS 282
PTS + V+ P++ P D + + PP+P F P SS + P S
Sbjct: 1838 PTSTSSDDVFVKPQAPPPPPAPSRIPIQDSLSQAQTSQPPSP----QVFSPGSSNSRPPS 1893
Query: 283 A-DVFSSVPFGTAAVPSGY--------VAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVM 333
D ++ + P G+ + P +PL + PV +
Sbjct: 1894 PMDPYAKMVGTPRPPPVGHSFSRRNSAAPVENCTPLSSVSRPLQMNETTANRPSPVRDLC 1953
Query: 334 PGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGT 393
+ P P P P + QFP + + V+ A +GP+ GT
Sbjct: 1954 SSSTTN--NDPYAKPP-DTPRPVMTDQFPKSLGLSRSPVVSEQTA--KGPIAA-----GT 2003
Query: 394 SDS-TRSSPQTDKPRQKMGKETFKDFQMAQPP----PVPSRKPDQPSLTCTSEAFSSYFN 448
SD T+ SP+ D +++ +++ + P P P + P QP + +
Sbjct: 2004 SDHFTKPSPRADVFQRQRIPDSYARPLLTPAPLDSGPGPFKTPMQPPPSSQDP-----YG 2058
Query: 449 KVGVAQDTDDCDDFDISQLNLTPVT------STTPSTNSPPTPAPRQSS----PSK--SS 496
V A D ++ L P+ S P + P TP P + PS+ S
Sbjct: 2059 SVSQASRRLSVDPYERPALTPRPIDNFSHNQSNDPYSQPPLTPHPAVNESFAHPSRAFSQ 2118
Query: 497 ASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISP 551
S PT+ D + + +P + + A SN+DP+ +P G P + P
Sbjct: 2119 PGTISRPTSQDPYSQPPGTPRPVVDSYSQSSGTARSNTDPYSQPPGTPRPTTVDP 2173
Score = 36.6 bits (83), Expect = 0.062
Identities = 55/248 (22%), Positives = 76/248 (30%), Gaps = 35/248 (14%)
Query: 325 AQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFM-PTQTVMPLPAAMFQGP 383
++ PV PIA G F Q P ++ P T PL + GP
Sbjct: 1985 SRSPVVSEQTAKGPIAAGTSDHFTKPSPRADVFQRQRIPDSYARPLLTPAPLDSG--PGP 2042
Query: 384 L-TPLATVPGTSDSTRSSPQ---------------TDKPRQKMGKETFKDFQMAQPPPVP 427
TP+ P + D S Q T +P D +QPP P
Sbjct: 2043 FKTPMQPPPSSQDPYGSVSQASRRLSVDPYERPALTPRPIDNFSHNQSND-PYSQPPLTP 2101
Query: 428 -----------SRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTT 476
SR QP + Y G + D SQ + T ++T
Sbjct: 2102 HPAVNESFAHPSRAFSQPGTISRPTSQDPYSQPPGTPRPVVD----SYSQSSGTARSNTD 2157
Query: 477 PSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDP 536
P + P TP P P T D+F + S+ P G+ S P
Sbjct: 2158 PYSQPPGTPRPTTVDPYSQQPQTPRPSTQTDLFVTPVTNQRHSDPYAHPPGTPRPGISVP 2217
Query: 537 FGEPSGEP 544
+ +P P
Sbjct: 2218 YSQPPATP 2225
Score = 29.6 bits (65), Expect = 7.6
Identities = 18/63 (28%), Positives = 29/63 (46%), Gaps = 1/63 (1%)
Query: 239 PVSAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPS 298
P++ +Q + FG T D+ P P + G +F SS+ + + FS V VP+
Sbjct: 2303 PMTPRSQSDSFGTSQTAHDVADQPRPGSEG-SFCASSNSPMHSQGQQFSGVSQLPGPVPT 2361
Query: 299 GYV 301
V
Sbjct: 2362 SGV 2364
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 53.9 bits (128), Expect = 4e-07
Identities = 58/220 (26%), Positives = 76/220 (34%), Gaps = 46/220 (20%)
Query: 314 QPLVQQQMVMGAQPPVAQVMPGA------------------QPIAWGQPGLFPATQQPWP 355
QP +QQ + QPP +Q +P P+A QP P Q P
Sbjct: 267 QPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQP 326
Query: 356 TVA-GQFPPAAFMPTQTVMPL---PAAMFQGPLTPLA---------------TVPGTSDS 396
V+ Q P + TQ + P + Q P+ P PG S
Sbjct: 327 LVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVS 386
Query: 397 TRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDT 456
S P P +T Q PPP PS +P QPS S S G A
Sbjct: 387 QSSLPMLSSPSPGQQVQTP---QSMPPPPQPSPQPGQPSSQPNSNVSS------GPAPSP 437
Query: 457 DDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSS 496
Q + +PVT+ TP S P+P P + + SS
Sbjct: 438 SSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSS 477
>gi|222418647 mucin 7, secreted precursor [Homo sapiens]
Length = 377
Score = 53.5 bits (127), Expect = 5e-07
Identities = 67/304 (22%), Positives = 108/304 (35%), Gaps = 31/304 (10%)
Query: 253 STPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWG 312
+ PP +P P D + TL A+ + SV F +A+ + LP
Sbjct: 79 NNPPKFPNPHQPPKHPDKNSSVVNPTLVATTQI-PSVTFPSASTKITTLPNVTFLPQ--- 134
Query: 313 QQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTV 372
+ + + VA + P P P P+ PP++ P +T
Sbjct: 135 NATTISSRENVNTSSSVATLAPVNSPAPQDT-----TAAPPTPSATTPAPPSSSAPPETT 189
Query: 373 M--PLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRK 430
P P+A Q P P ++ P + + +P P + PP +
Sbjct: 190 AAPPTPSATTQAP--PSSSAPPETTAAPPTPPATTPAPPS----------SSAPPETTAA 237
Query: 431 PDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQS 490
P PS T + SS + T D S + P T+ P T S TPAP S
Sbjct: 238 PPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSS 297
Query: 491 -SPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASS---NSDPFGEPSGEPSG 546
+P +++A+ + P + +P SE AP +S + +P+ P
Sbjct: 298 PAPQETTAAPITTPNSSPT----TLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAPGQ 353
Query: 547 DNIS 550
+ IS
Sbjct: 354 NKIS 357
>gi|222418649 mucin 7, secreted precursor [Homo sapiens]
Length = 377
Score = 53.5 bits (127), Expect = 5e-07
Identities = 67/304 (22%), Positives = 108/304 (35%), Gaps = 31/304 (10%)
Query: 253 STPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWG 312
+ PP +P P D + TL A+ + SV F +A+ + LP
Sbjct: 79 NNPPKFPNPHQPPKHPDKNSSVVNPTLVATTQI-PSVTFPSASTKITTLPNVTFLPQ--- 134
Query: 313 QQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTV 372
+ + + VA + P P P P+ PP++ P +T
Sbjct: 135 NATTISSRENVNTSSSVATLAPVNSPAPQDT-----TAAPPTPSATTPAPPSSSAPPETT 189
Query: 373 M--PLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRK 430
P P+A Q P P ++ P + + +P P + PP +
Sbjct: 190 AAPPTPSATTQAP--PSSSAPPETTAAPPTPPATTPAPPS----------SSAPPETTAA 237
Query: 431 PDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQS 490
P PS T + SS + T D S + P T+ P T S TPAP S
Sbjct: 238 PPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSS 297
Query: 491 -SPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASS---NSDPFGEPSGEPSG 546
+P +++A+ + P + +P SE AP +S + +P+ P
Sbjct: 298 PAPQETTAAPITTPNSSPT----TLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAPGQ 353
Query: 547 DNIS 550
+ IS
Sbjct: 354 NKIS 357
>gi|222418645 mucin 7, secreted precursor [Homo sapiens]
Length = 377
Score = 53.5 bits (127), Expect = 5e-07
Identities = 67/304 (22%), Positives = 108/304 (35%), Gaps = 31/304 (10%)
Query: 253 STPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWG 312
+ PP +P P D + TL A+ + SV F +A+ + LP
Sbjct: 79 NNPPKFPNPHQPPKHPDKNSSVVNPTLVATTQI-PSVTFPSASTKITTLPNVTFLPQ--- 134
Query: 313 QQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTV 372
+ + + VA + P P P P+ PP++ P +T
Sbjct: 135 NATTISSRENVNTSSSVATLAPVNSPAPQDT-----TAAPPTPSATTPAPPSSSAPPETT 189
Query: 373 M--PLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRK 430
P P+A Q P P ++ P + + +P P + PP +
Sbjct: 190 AAPPTPSATTQAP--PSSSAPPETTAAPPTPPATTPAPPS----------SSAPPETTAA 237
Query: 431 PDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQS 490
P PS T + SS + T D S + P T+ P T S TPAP S
Sbjct: 238 PPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSS 297
Query: 491 -SPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASS---NSDPFGEPSGEPSG 546
+P +++A+ + P + +P SE AP +S + +P+ P
Sbjct: 298 PAPQETTAAPITTPNSSPT----TLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAPGQ 353
Query: 547 DNIS 550
+ IS
Sbjct: 354 NKIS 357
>gi|50511947 cajalin 2 isoform b [Homo sapiens]
Length = 510
Score = 51.2 bits (121), Expect = 2e-06
Identities = 34/127 (26%), Positives = 58/127 (45%), Gaps = 4/127 (3%)
Query: 42 YKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKT 101
YKA +G + RG + QD+ K++ + + + I L++S+ G+K D
Sbjct: 312 YKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATN 371
Query: 102 GALQHHHAVHEISYIAKDITDHRAFGYVC-GKEGNHRFVAIKTA---QAAEPVILDLRDL 157
+ H + IS A+D D F Y+ + NH + + TA A +IL L
Sbjct: 372 KNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQA 431
Query: 158 FQLIYEL 164
F++ Y+L
Sbjct: 432 FEVAYQL 438
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 51.2 bits (121), Expect = 2e-06
Identities = 34/127 (26%), Positives = 58/127 (45%), Gaps = 4/127 (3%)
Query: 42 YKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKT 101
YKA +G + RG + QD+ K++ + + + I L++S+ G+K D
Sbjct: 1062 YKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATN 1121
Query: 102 GALQHHHAVHEISYIAKDITDHRAFGYVC-GKEGNHRFVAIKTA---QAAEPVILDLRDL 157
+ H + IS A+D D F Y+ + NH + + TA A +IL L
Sbjct: 1122 KNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQA 1181
Query: 158 FQLIYEL 164
F++ Y+L
Sbjct: 1182 FEVAYQL 1188
>gi|10047134 cajalin 2 isoform c [Homo sapiens]
Length = 414
Score = 51.2 bits (121), Expect = 2e-06
Identities = 34/127 (26%), Positives = 58/127 (45%), Gaps = 4/127 (3%)
Query: 42 YKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKT 101
YKA +G + RG + QD+ K++ + + + I L++S+ G+K D
Sbjct: 228 YKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATN 287
Query: 102 GALQHHHAVHEISYIAKDITDHRAFGYVC-GKEGNHRFVAIKTA---QAAEPVILDLRDL 157
+ H + IS A+D D F Y+ + NH + + TA A +IL L
Sbjct: 288 KNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQA 347
Query: 158 FQLIYEL 164
F++ Y+L
Sbjct: 348 FEVAYQL 354
>gi|26051278 nuclear pore membrane protein 121 [Homo sapiens]
Length = 984
Score = 49.7 bits (117), Expect = 7e-06
Identities = 82/361 (22%), Positives = 131/361 (36%), Gaps = 52/361 (14%)
Query: 218 NIYQVPTSQKKEGVYDVPKSQPVSAVTQL---------ELFGDMSTPPDITSPPTPATPG 268
++ + P + + +P + P S T L E M TPP + PP P + G
Sbjct: 296 SVTETPPITQPSFTFTLPAAAPASPPTSLLAPSTNPLLESLKKMQTPPSL--PPCPESAG 353
Query: 269 ----DAFIPSSSQTLPASADVFSSVPFGTAAVPS----------GYVAMGAVLPSFWGQQ 314
+A P + +L + S P G PS G + +++P+ +
Sbjct: 354 AATTEALSPPKTPSLLPPLGLSQSGPPGLLPSPSFDSKPPTTLLGLIPAPSMVPATDTKA 413
Query: 315 PLVQQQMVMGAQPPVAQVMPGAQP---IAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQT 371
P Q A P A P P +G P++ P A PP F P T
Sbjct: 414 PPTLQAET--ATKPQATSAPSPAPKQSFLFGTQNTSPSS--PAAPAASSAPPM-FKPIFT 468
Query: 372 VMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKP 431
P +GP P +V T+ S+ S P T + F P+P+
Sbjct: 469 APPKSEK--EGPTPPGPSVTATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFF 526
Query: 432 DQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSS 491
Q + T+ ++ G+A T + P+TS +PST+S PA
Sbjct: 527 KQTTTPATAPTTTAPLF-TGLASATSA----------VAPITSASPSTDSASKPAFGFGI 575
Query: 492 PSKSSASHASDPTTDDIFEEG--FESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNI 549
S SS+S ++ +T + F +P S P A + FG+P P+ +
Sbjct: 576 NSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTP----AMGSIFQFGKPPALPTTTTV 631
Query: 550 S 550
+
Sbjct: 632 T 632
Score = 43.5 bits (101), Expect = 5e-04
Identities = 82/345 (23%), Positives = 123/345 (35%), Gaps = 70/345 (20%)
Query: 248 LFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVL 307
L + +T P TS P+PA P +F+ + T P+S + P ++A P +
Sbjct: 417 LQAETATKPQATSAPSPA-PKQSFLFGTQNTSPSSP----AAPAASSAPP--------MF 463
Query: 308 PSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFM 367
+ P +++ P V P + + P Q P + PPA+
Sbjct: 464 KPIFTAPPKSEKEGPTPPGPSVTATAPSSSSLPTTTSTTAPTFQ---PVFSSMGPPAS-- 518
Query: 368 PTQTVMPLPAAMFQGPLTPLATVPGTSDS---------------TRSSPQTD---KPRQK 409
+PLPA F+ TP AT P T+ T +SP TD KP
Sbjct: 519 -----VPLPAPFFKQTTTP-ATAPTTTAPLFTGLASATSAVAPITSASPSTDSASKPAFG 572
Query: 410 MGKETFKDFQM--------AQPPPVPSRKPDQPSLTCTSEAFSSY-FNKVGVAQDTDDCD 460
G + + A P P + + T S + F K T
Sbjct: 573 FGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVT 632
Query: 461 DFDISQLNLTPVTSTTPSTN------SPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFE 514
F S P +++ + + + T AP SS + S+ S PT F F
Sbjct: 633 TFSQSLHTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPT----FNIPFG 688
Query: 515 SPSKSEEQEAPDGSQASSNSDP-FGEPSGEPSG---DNISPQAGS 555
S +KS P S +N P FG G+P G ++P GS
Sbjct: 689 SSAKS-----PLPSYPGANPQPAFGAAEGQPPGAAKPALAPSFGS 728
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 48.9 bits (115), Expect = 1e-05
Identities = 84/363 (23%), Positives = 122/363 (33%), Gaps = 41/363 (11%)
Query: 213 PETEENIYQVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPP--DITSPPTPATPGDA 270
PET +I P P++ P A L+ + +PP + +PP A P A
Sbjct: 581 PETPSSIATPP-----------PQAPPALASPPLQ---GLPSPPLSPLATPPPQAPPXLA 626
Query: 271 FIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVA 330
P + P ++ S + + P+ P P VQ A PPV+
Sbjct: 627 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 686
Query: 331 QVMPGAQPIAWGQPGLF--PATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLA 388
P A P + P L P P P + P+A P Q PL A Q P +P A
Sbjct: 687 ---PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPA 743
Query: 389 TVPGTSDST---RSSPQTDKPRQKMGKETFKDFQMA-------QPPPVPSRKPDQ--PSL 436
+ P + +T R P P ++ M+ Q PP + P Q PS
Sbjct: 744 SPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSP 803
Query: 437 TCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSS 496
+ + + + + P+ PS + PT + P+
Sbjct: 804 PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGP 863
Query: 497 ASHASDPTTDDIFEEGFESP---SKSEEQEAPD--GSQASSNSDP---FGEPSGEPSGDN 548
+ S P G P S S PD G +S+ S P G SG G
Sbjct: 864 DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAA 923
Query: 549 ISP 551
SP
Sbjct: 924 ASP 926
Score = 44.7 bits (104), Expect = 2e-04
Identities = 71/310 (22%), Positives = 104/310 (33%), Gaps = 43/310 (13%)
Query: 255 PPDITSPPTPATPGDAFIP---------SSSQTLPASADVFSSVPFGTAAVPSGYVAMGA 305
PP +T+PP A P IP S S P S SS+ T+ G + A
Sbjct: 369 PPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSL---GSPTLQA 425
Query: 306 VLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIA--WGQPGLFPATQQPWPTVAGQFPP 363
SF P Q + P A P + P+ P P P V+ P
Sbjct: 426 T-HSFLTMSPRQTQASLTSPSRP-ASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSP 483
Query: 364 AAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQP 423
P Q + L + Q PL+ L P + S+ + P P + ++ P
Sbjct: 484 LTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAP 543
Query: 424 PPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPP 483
PP+ T ++ + + +T C Q +P+T+ P T S
Sbjct: 544 PPLQ---------TASAPLTTPHL-------ETPPCPAPCPLQAPPSPLTTPPPETPSSI 587
Query: 484 TPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGE 543
P Q+ P+ AS P +G SP S P + P P
Sbjct: 588 ATPPPQAPPAL-----ASPPL------QGLPSPPLSPLATPPPQAPPXLALPPLQAPPSP 636
Query: 544 PSGDNISPQA 553
P+ +SP A
Sbjct: 637 PASPPLSPLA 646
Score = 32.3 bits (72), Expect = 1.2
Identities = 43/179 (24%), Positives = 62/179 (34%), Gaps = 26/179 (14%)
Query: 235 PKSQPVSAVTQLELFGDMSTPPDITSPPTPATPG-DAFIPSSSQTL---PASADVFSSVP 290
P++ PV A L++ P + +P P TPG D + TL P S P
Sbjct: 829 PQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSP 888
Query: 291 FGTAAVP--SGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQ----P 344
T + P +G+ + P + + PP A+ + P AW + P
Sbjct: 889 SSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAE-LAACHPAAWSRGPAPP 947
Query: 345 GLF---PATQQPWPTVAGQFPPAAFMP------TQTVMPLPAAMFQGPLTPLATVPGTS 394
F P PWP G ++ P P A+ GP PGTS
Sbjct: 948 LAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGP------SPGTS 1000
>gi|73808090 zinc finger protein 207 isoform b [Homo sapiens]
Length = 463
Score = 48.1 bits (113), Expect = 2e-05
Identities = 69/301 (22%), Positives = 106/301 (35%), Gaps = 59/301 (19%)
Query: 261 PPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQ 320
PP P PG P +P + +P +P G SF G+ ++
Sbjct: 148 PPVPGAPG--MPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMG 205
Query: 321 MVMGAQPPVAQVMPG---AQPIAWGQPGLFPATQQPWPTVAG--QFPPAAFMPTQTVMPL 375
+M P + +MPG P +PG+ P TQ + G PPA PT TV P
Sbjct: 206 GMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPA---PTATV-PA 261
Query: 376 PAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPS 435
P PL P A G + + P DF+ P + +P +P+
Sbjct: 262 PQPPVTKPLFPSA---GQAQAAVQGP------------VGTDFKPLNSTPATTTEPPKPT 306
Query: 436 LTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPA--PRQSSPS 493
+++ +S TSTT ST + P + + ++ +
Sbjct: 307 FPAYTQSTAS--------------------------TTSTTNSTAAKPAASITSKPATLT 340
Query: 494 KSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQA 553
+SA+ +DI E + ++ P QA P G P P G + PQ
Sbjct: 341 TTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQA-----PIGNPPVGPIGGMMPPQP 395
Query: 554 G 554
G
Sbjct: 396 G 396
Score = 31.6 bits (70), Expect = 2.0
Identities = 33/127 (25%), Positives = 51/127 (40%), Gaps = 15/127 (11%)
Query: 253 STPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYV-AMGAVLPSFW 311
STP T PP P P A+ S++ T +S TAA P+ + + A L +
Sbjct: 294 STPATTTEPPKPTFP--AYTQSTAST--------TSTTNSTAAKPAASITSKPATLTTTS 343
Query: 312 GQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQT 371
L+ + + AQ+ + + +PG P P + G PP +P Q
Sbjct: 344 ATSKLIHPDEDISLEERRAQLPKYQRNLP--RPGQAPIGNPPVGPIGGMMPPQPGIPQQQ 401
Query: 372 VM--PLP 376
M P+P
Sbjct: 402 GMRPPMP 408
>gi|222352122 hypothetical protein LOC284297 [Homo sapiens]
Length = 1573
Score = 47.0 bits (110), Expect = 5e-05
Identities = 79/346 (22%), Positives = 117/346 (33%), Gaps = 36/346 (10%)
Query: 221 QVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPAT-PGDAFIPSSSQTL 279
QVP S + P S VS + S PD + P P T P P TL
Sbjct: 1117 QVPESDTTPDLDTTPYSSTVS---------EYSRSPDPSPSPHPTTTPDPTMAPDPITTL 1167
Query: 280 -PASADVFSSVPFGTAAVPSGYVAMGAVLPS-FWGQQPLVQQQMVMGAQPPVAQVMPGAQ 337
P F + P T + ++P QP + P P Q
Sbjct: 1168 NPTVTPHFPTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTT--ITHSTMIPDPTTTP--Q 1223
Query: 338 PIAWGQPGLFPATQQPWPTVAGQ---FPPAAFMPTQTVMPLPAAMFQGPLTPLATV---P 391
P QP P + P PT + +P T P P Q P T P
Sbjct: 1224 PFTTMQPTTTPHSTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTMQPTTMPHPTTTPHP 1283
Query: 392 GTSDSTRSSPQ-TDKPRQKMGKE-TFKDFQMAQPPPVPSRKPDQPSLTCTS--------E 441
T+ ++P T P M + T + P P + P P + T
Sbjct: 1284 TTTPHPTTTPHPTTTPHPTMTPDPTTTPYPTTTPDPTTTPHPTTPDPSSTPVITTVSLPT 1343
Query: 442 AFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHAS 501
+ + + +A ++ P TST+ P+PA +SSPS+SS + +
Sbjct: 1344 SLGTELSSPTLAPTVKPSLHPQLTFTAPAPHTSTSQIPTLEPSPA-LESSPSRSSTATSM 1402
Query: 502 DP-TTDDIFEEGFESPSKS--EEQEAPDGSQASSNSDPFGEPSGEP 544
DP +T+D +SP+ + S + + DP P+ P
Sbjct: 1403 DPLSTEDFKPPRSQSPNLTPPPTHTPHSASDLTVSPDPLLSPTAHP 1448
Score = 31.2 bits (69), Expect = 2.6
Identities = 62/270 (22%), Positives = 92/270 (34%), Gaps = 45/270 (16%)
Query: 259 TSPPTPAT--------PGDAFIPSSSQTL-PASA---DVFSSVPFGTAAVPSGYVAMGAV 306
T+PPTP+ PG A SS+ L P SA + S P + P
Sbjct: 1002 TAPPTPSPGPSASPGPPGPALTSDSSRELTPHSALTSEATSDAPDTSPPTPD-------- 1053
Query: 307 LPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAF 366
P+ L+ P + V+P P + P PT+ +
Sbjct: 1054 -PASRTNPDLILTSPDFALSTPDSSVVPALTP---------EPSPTPLPTLPKELTSDPS 1103
Query: 367 MPTQ--TVMPLPAAMFQGPLTP-LATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQP 423
P++ ++ P + + TP L T P +S + S D P T D MA
Sbjct: 1104 TPSEVTSLSPTSEQVPESDTTPDLDTTPYSSTVSEYSRSPD-PSPSPHPTTTPDPTMAPD 1162
Query: 424 P------PVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTP 477
P V P P T T + + + T I+ + P +TTP
Sbjct: 1163 PITTLNPTVTPHFPTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTITHSTMIPDPTTTP 1222
Query: 478 S--TNSPPTPAPRQSSPSKSSASHASDPTT 505
T PT P ++P ++ H PTT
Sbjct: 1223 QPFTTMQPTTTPHSTTPHPTTTPH---PTT 1249
Score = 29.3 bits (64), Expect = 9.9
Identities = 44/180 (24%), Positives = 60/180 (33%), Gaps = 30/180 (16%)
Query: 387 LATVPGTS-DSTRSSPQTDKPRQKMGKETFK------DFQMAQPPPVP----SRKPDQPS 435
LAT P S ++ T K KM K T K QPP +P SR P
Sbjct: 600 LATKPSASVTASVLEKTTTKAPGKMPKSTKKWVTKNAKRPTTQPPVMPTTKHSRAQSPPD 659
Query: 436 LTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVT-------STTPSTNSPPTPAPR 488
LT + A T + S+ P T S T +T +P P R
Sbjct: 660 LTSQTTAAL-----------TTEASRRPTSEFTRRPTTEAPQRWTSHTTATLTPQAPRER 708
Query: 489 QSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDN 548
+ + T + + S E P+GS S DP PS +G++
Sbjct: 709 TTKTMAMLTTQGPQEMTSESTIKSIPQASLEPSAEIPEGS-PESPKDPAPSPSVSTTGES 767
>gi|239743232 PREDICTED: hypothetical protein XP_002342775 [Homo
sapiens]
Length = 834
Score = 47.0 bits (110), Expect = 5e-05
Identities = 82/367 (22%), Positives = 129/367 (35%), Gaps = 64/367 (17%)
Query: 218 NIYQVPTSQKKEGVYDVPKSQPVSAVTQL---------ELFGDMSTPPDITSPPTPATPG 268
++ + P + + +P + P S T L E M TPP + PP P + G
Sbjct: 145 SVTETPPITQPSFTFTLPAAAPASPPTSLLAPSTNPLLESLKKMQTPPSL--PPCPESAG 202
Query: 269 ----DAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMG 324
+A P + L + S P G +PS PSF P ++
Sbjct: 203 AATTEALSPPKTPNLLPPLGLSQSGPPGL--LPS---------PSFDSNPPTTLLGLIPA 251
Query: 325 AQ---------PPVAQVMPGAQPIAWGQPGLFP------ATQQPWPTVAGQFPPAAFMPT 369
PP Q +P A P P TQ P+ PAA +
Sbjct: 252 PSMVPATDTKAPPTLQAETTTKPQATSAPSPAPKQSFLFGTQNTSPSSPAA--PAASSAS 309
Query: 370 QTVMPL----PAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPP 425
P+ P + +GP P +V T+ S+ S P T + F P
Sbjct: 310 PMFKPIFTAPPKSEKEGPTPPGPSVSATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVP 369
Query: 426 VPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTP 485
+P+ Q + T+ ++ G+A T + P+TS +PST+S P
Sbjct: 370 LPAPFFKQTTTPATAPTTTAPLF-TGLASATSA----------VAPITSASPSTDSASKP 418
Query: 486 APRQSSPSKSSASHASDPTTDDIFEEG--FESPSKSEEQEAPDGSQASSNSDPFGEPSGE 543
A S SS+S ++ +T + F +P S P A + FG+P
Sbjct: 419 AFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTP----AMGSIFQFGKPPAL 474
Query: 544 PSGDNIS 550
P+ ++
Sbjct: 475 PTTTTVT 481
Score = 43.9 bits (102), Expect = 4e-04
Identities = 84/345 (24%), Positives = 122/345 (35%), Gaps = 70/345 (20%)
Query: 248 LFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVL 307
L + +T P TS P+PA P +F+ + T P+S A P+ A
Sbjct: 266 LQAETTTKPQATSAPSPA-PKQSFLFGTQNTSPSSP-----------AAPAASSASPMFK 313
Query: 308 PSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFM 367
P F P +++ P V+ P + + P Q P + PPA+
Sbjct: 314 PIFTAP-PKSEKEGPTPPGPSVSATAPSSSSLPTTTSTTAPTFQ---PVFSSMGPPAS-- 367
Query: 368 PTQTVMPLPAAMFQGPLTPLATVPGTSDS---------------TRSSPQTD---KPRQK 409
+PLPA F+ TP AT P T+ T +SP TD KP
Sbjct: 368 -----VPLPAPFFKQTTTP-ATAPTTTAPLFTGLASATSAVAPITSASPSTDSASKPAFG 421
Query: 410 MGKETFKDFQM--------AQPPPVPSRKPDQPSLTCTSEAFSSY-FNKVGVAQDTDDCD 460
G + + A P P + + T S + F K T
Sbjct: 422 FGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVT 481
Query: 461 DFDISQLNLTPVTSTTPSTN------SPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFE 514
F S P +++ + + + T AP SS + S+ S PT F F
Sbjct: 482 TFSQSLPTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPT----FNIPFG 537
Query: 515 SPSKSEEQEAPDGSQASSNSDP-FGEPSGEPSG---DNISPQAGS 555
S +KS P S +N P FG G+P G ++P GS
Sbjct: 538 SSAKS-----PLPSYPGANPQPAFGAAEGQPPGAAKPALTPSFGS 577
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 47.0 bits (110), Expect = 5e-05
Identities = 87/370 (23%), Positives = 119/370 (32%), Gaps = 64/370 (17%)
Query: 223 PTSQKKEGVYDVPKSQPVS-AVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPA 281
P S K PK P A T G TPP +P PA + P + TLPA
Sbjct: 1294 PPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPS--PKGTPTLPA 1351
Query: 282 SADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAW 341
+ P T + G A PS G + G P + P + +
Sbjct: 1352 TTPSSKGGPT-TPSSKEGPTPPAAT-PSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIP 1409
Query: 342 GQPGLFPATQ-----QPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLA----TVPG 392
P PAT P+ PPA + P +A GP TP + T+P
Sbjct: 1410 LSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPA 1469
Query: 393 ----------------TSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPS-----RKP 431
TS S + +P T P MG T + P VP+ R P
Sbjct: 1470 VTPPSPKEPPAPKQVATSSSPKKAPATPAP---MGAPTLPAVIPSSPKEVPATPSSRRDP 1526
Query: 432 DQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPT-PAPRQS 490
P+ T S+ + + L P T PS P P P+++
Sbjct: 1527 IAPTATLLSKKTPATL----------------APKEALIPPAMTVPSPKKTPAIPTPKEA 1570
Query: 491 SPSKSSASHASDPTTDDIFEEGFESP---------SKSEEQEAPDGSQASSNSDPFGEPS 541
+ SS +S P +G SP + +EAP + S G +
Sbjct: 1571 PATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPAT 1630
Query: 542 GEPSGDNISP 551
P G SP
Sbjct: 1631 PAPKGTPTSP 1640
Score = 45.1 bits (105), Expect = 2e-04
Identities = 77/305 (25%), Positives = 100/305 (32%), Gaps = 50/305 (16%)
Query: 254 TPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGY-VAMGAVLPSFWG 312
TPP +T P +P P + T PA+ +P G A LPS G
Sbjct: 1010 TPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKG 1069
Query: 313 QQPLVQQQMVMGAQPPVAQVMPG-----AQPIAWGQPGLFPATQQPWPTVAGQFPPAAFM 367
+ GA P A P A P G P + PA P P PP
Sbjct: 1070 GP---ATPSLKGAPTPPAATPPSPKGGPATPSPKGAP-MPPAATPPSPKGGLATPPHKGA 1125
Query: 368 PTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVP 427
PT PAA P LAT P T +P P K G +A PP P
Sbjct: 1126 PT-----TPAATPPSPKGGLATPPPKGAPT--TPAATPPSPKGG--------LATPP--P 1168
Query: 428 SRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAP 487
P P+ T S K G+A +P + T +PP+P
Sbjct: 1169 KGAPTTPAATPPSP-------KGGLATP--------------SPKGAPTTPAATPPSPKG 1207
Query: 488 RQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDP-FGEPSGEPSG 546
++PS A + T + G +PS P + S P P G P+
Sbjct: 1208 GLATPSPKGAP-TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTP 1266
Query: 547 DNISP 551
+P
Sbjct: 1267 PAATP 1271
Score = 45.1 bits (105), Expect = 2e-04
Identities = 80/318 (25%), Positives = 114/318 (35%), Gaps = 62/318 (19%)
Query: 209 PIRDPETEENIYQVPTSQKKEGVYDVPKSQPVS-AVTQLELFGDMSTPPDITSPPTPATP 267
P P + P S K+ PK P S AV L +TP TP+
Sbjct: 1372 PAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSK- 1430
Query: 268 GD----AFIPSSSQTLPASADVFSSVPFGTAAVPS--GYVAMGAVLPSFWGQQPLVQQQM 321
GD A P S + PA+ S P G A PS G + AV P ++P +Q+
Sbjct: 1431 GDLTPPAVTPVSLKKAPAT-----SAPKGGPATPSSKGDPTLPAVTPPS-PKEPPAPKQV 1484
Query: 322 VMGAQPPVAQVMPGAQ------PIAWGQPGLFPATQQ-------PWPTVAGQFPPAAFMP 368
+ P A P + P PAT P T+ + PA P
Sbjct: 1485 ATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAP 1544
Query: 369 TQTVMPLPAAMFQGP-LTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDF----QMAQP 423
+ ++P PA P TP P + +T SS + P + T+K ++ P
Sbjct: 1545 KEALIP-PAMTVPSPKKTPAIPTPKEAPATPSSKEASSP-PAVTPSTYKGAPSPKELLIP 1602
Query: 424 P----PVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPST 479
P P P P P++T S + G A TP TP T
Sbjct: 1603 PAVTSPSPKEAPTPPAVTPPSP-------EKGPA----------------TPAPKGTP-T 1638
Query: 480 NSPPTPAPRQSSPSKSSA 497
+ P TP+ + SP+ ++
Sbjct: 1639 SPPVTPSSLKDSPTSPAS 1656
Score = 41.6 bits (96), Expect = 0.002
Identities = 81/359 (22%), Positives = 113/359 (31%), Gaps = 60/359 (16%)
Query: 223 PTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPAS 282
P S KK PK P + ++ + TPP PP P + P + PA
Sbjct: 1440 PVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAP 1499
Query: 283 AD------VFSSVPFGTAAVPSGY---VAMGAVLPS------FWGQQPLVQQQMVMGAQ- 326
V S P A PS +A A L S ++ L+ M + +
Sbjct: 1500 MGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPK 1559
Query: 327 -------PPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQF-PPAAFMPTQTVMPLPAA 378
P A P ++ A P + P+T + P+ PPA P+ P P A
Sbjct: 1560 KTPAIPTPKEAPATPSSKE-ASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPA 1618
Query: 379 MF-----QGPLTPLATVPGTSDSTRSSPQTDKPRQ---------------------KMGK 412
+ +GP TP TS S D P K G
Sbjct: 1619 VTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGP 1678
Query: 413 ETFKDFQMAQPPP------VPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQ 466
K+ +A P P+RK Q T S A S A++ ++
Sbjct: 1679 TALKEVLVAPAPESTPIITAPTRKGPQ---TKKSSATSPPICPDPSAKNGSKGPLSTVAP 1735
Query: 467 LNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAP 525
L PV + T + P S AS P T FE+ P + AP
Sbjct: 1736 APLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAP 1794
Score = 40.8 bits (94), Expect = 0.003
Identities = 83/348 (23%), Positives = 112/348 (32%), Gaps = 48/348 (13%)
Query: 223 PTSQKKEGVYDVPKSQPVS-AVTQLELFGDMSTPPDITSPPTP-ATPGDAFIPSSSQTLP 280
P S K PK P+ A T G ++TPP +P TP ATP P P
Sbjct: 1087 PPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPS---PKGGLATP 1143
Query: 281 ASADVFSSVPFGTAAVPSGYVA----MGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGA 336
+ P T P G +A GA P+ P + + P A P A
Sbjct: 1144 PPKGA-PTTPAATPPSPKGGLATPPPKGA--PTTPAATPPSPKGGLATPSPKGAPTTPAA 1200
Query: 337 QPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDS 396
P + + GL + + PT PP+ T P A P TP AT P
Sbjct: 1201 TPPS-PKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGA-----PTTPAATPPSPKGG 1254
Query: 397 TRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDT 456
+ P P +A PP P+ +T S K G A
Sbjct: 1255 PATPPPKGAPTPPAATPPSLKGGLATPP--HKGAPNPAVVTPPSP-------KGGPATSP 1305
Query: 457 DDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASD------PTTDDIFE 510
TP +T PS P P + +P+ + + S P T +
Sbjct: 1306 PKGAP--------TPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSK 1357
Query: 511 EGFESPSKSEEQEAPDGSQASSNSDPFGEPSGE-------PSGDNISP 551
G +PS E P + + PS + P GD SP
Sbjct: 1358 GGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSP 1405
Score = 32.3 bits (72), Expect = 1.2
Identities = 66/300 (22%), Positives = 101/300 (33%), Gaps = 70/300 (23%)
Query: 253 STPPD--ITSPPTPATPGDA-FIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPS 309
S PD I + +P +P +A F+P +S + S D ++ T P G AV P
Sbjct: 814 SAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTP- 872
Query: 310 FWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPAT----QQPWPTVAGQFPPAA 365
L + + + PP P + + + G PAT Q P ++ P A
Sbjct: 873 ------LSPKGVTL---PPKETPTPSVVNLPFPKEG--PATPAPKQAPALSMTSSSPKKA 921
Query: 366 -FMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPP 424
P +P + P P AT P S + P T P+ + A P
Sbjct: 922 RATPAPKGIPASPSPKGAPTPPAATPP----SPKGGPATPSPK-------WAPTPPAATP 970
Query: 425 PVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPT 484
P P P PS P + TP +PP+
Sbjct: 971 PSPKGGPATPS-----------------------------------PKGAPTPPAATPPS 995
Query: 485 PAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEP 544
P ++PS A + P +G SP+ + + A++ P G P+ P
Sbjct: 996 PKGGPATPSPKGA--PTPPAVTPPSPKG--SPAATPFPKGASTPPAATPPSPKGSPAATP 1051
Score = 29.3 bits (64), Expect = 9.9
Identities = 67/325 (20%), Positives = 110/325 (33%), Gaps = 55/325 (16%)
Query: 254 TPPDITSPPT---PATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSF 310
TPP +T P PATP P+S P+S P A+V MGA +P
Sbjct: 1615 TPPAVTPPSPEKGPATPAPKGTPTSPPVTPSS---LKDSPTSPASVTC---KMGATVPQ- 1667
Query: 311 WGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFM--- 367
+ L ++ + + P + PI P T++ T P +
Sbjct: 1668 -ASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGS 1726
Query: 368 --PTQTVMPLPAAMFQ-----------------GPLTP---LATVPGTSDS-TRSSPQTD 404
P TV P P Q GPL P A+ P T+ + + P+ +
Sbjct: 1727 KGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPE 1786
Query: 405 KPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDI 464
+A P PVP+ P Q L + +K D D+ +
Sbjct: 1787 SASVSAAPSPPVSLPLA-PSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDEL----L 1841
Query: 465 SQLNLTPVTSTTPS----TNSP---------PTPAPRQSSPSKSSASHASDPTTDDIFEE 511
+ P++ P N P PTP+ +Q + S + + + E
Sbjct: 1842 PLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPEL 1901
Query: 512 GFESPSKSEEQEAPDGSQASSNSDP 536
+ +++ Q+A + A + +P
Sbjct: 1902 EEQDSTQATTQQAQLAAAAEIDEEP 1926
>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
1 [Homo sapiens]
Length = 1250
Score = 46.6 bits (109), Expect = 6e-05
Identities = 71/312 (22%), Positives = 99/312 (31%), Gaps = 61/312 (19%)
Query: 239 PVSAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAV-- 296
P + Q++ ++ P PP PA P T+PA + P T A
Sbjct: 745 PPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPP 804
Query: 297 ---------------PSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAW 341
P+ Y+ P P + +Q A+PP + + P +
Sbjct: 805 TPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVV-- 862
Query: 342 GQPGLFPATQQPWPTVAGQFPPAAFMP---TQTVMPLPAAMFQGPLTPLATVPGTSDSTR 398
+A QFPP P +Q + P+PA + + P S+
Sbjct: 863 -------------KQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSI 909
Query: 399 SSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDD 458
P D P E+ F P PVP+ P P A T D
Sbjct: 910 PVPSPDFPPPP--PESSLVFPPPPPSPVPAPPPPPPP----------------TASPTPD 951
Query: 459 CDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASD--PTTDDI---FEEGF 513
S T TS+ PPTP S S S A H P+ D + F
Sbjct: 952 KSG---SPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPA 1008
Query: 514 ESPSKSEEQEAP 525
ES S S+E P
Sbjct: 1009 ESGSPSKETLPP 1020
Score = 33.5 bits (75), Expect = 0.52
Identities = 65/276 (23%), Positives = 93/276 (33%), Gaps = 57/276 (20%)
Query: 255 PPDITSPPTPATPGDAFIPSSSQTLPASADV------FSSVP-FGTAAVPSGYVAMGAVL 307
PP PP P P P SQ+ P++ +S++ A+ SG +
Sbjct: 630 PPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTP 689
Query: 308 PSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAG--QF---- 361
P Q V+ Q+++ PP V P P PG A +P P QF
Sbjct: 690 PVMQSQS--VKPQILV---PPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPP 744
Query: 362 PPAAFMPTQTVM-----------PLPAAM-FQGPLTPLATVPGTSDS-------TRSSPQ 402
PP Q + P+PA + Q P PL T+P + + T+++P
Sbjct: 745 PPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPP 804
Query: 403 TDKPRQKMGKE--TFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCD 460
T P K+ F + PP P P+L + C
Sbjct: 805 TPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTL----------------PKQQSFCA 848
Query: 461 DFDISQLNLTP--VTSTTPSTNSPPTPAPRQSSPSK 494
S L+ P V PPTP +S P K
Sbjct: 849 KPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLK 884
>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
sapiens]
Length = 1560
Score = 46.6 bits (109), Expect = 6e-05
Identities = 80/333 (24%), Positives = 110/333 (33%), Gaps = 50/333 (15%)
Query: 231 VYDVPKSQP-VSAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASAD--VFS 287
V P++ P VS L L + P P A P A P S L +S + V
Sbjct: 621 VQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLG 680
Query: 288 SVPFGTAAVPSGYVAMGAVLPSFWGQQPL--------VQQQMVMGAQPPVAQVMPGAQPI 339
P T ++ LP QQPL V +++ A PP P A P+
Sbjct: 681 QPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAP-ATPV 739
Query: 340 AWGQPGLFPAT--QQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDST 397
A G GL P Q P A Q P AA + P+ Q PL +P +
Sbjct: 740 AKGA-GLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTR 798
Query: 398 RSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKP-DQPSLTCTSEAFSSYFNKVGVAQDT 456
S +P+ +++PP P P P T N++GV
Sbjct: 799 PPSRPPSRPQ-----------SVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVP--- 844
Query: 457 DDCDDFDISQLNLTPVTSTTPSTNSPPTPAPR-QSSPSKS---SASHASDPTTDDIFEEG 512
P ++ P+ PP P R QS P + A H +T
Sbjct: 845 -------------PPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASS 891
Query: 513 FESPSKSEEQEAPDGSQASSNSDPFGEPSGEPS 545
E+ S+ AP S P P P+
Sbjct: 892 SETSSR---LPAPTPSDFQLQFPPSQGPHKSPT 921
Score = 31.2 bits (69), Expect = 2.6
Identities = 56/228 (24%), Positives = 78/228 (34%), Gaps = 49/228 (21%)
Query: 343 QPGLFPAT---QQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRS 399
QP PAT +P P PP M P PAA + PL GT+
Sbjct: 1332 QPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPL-------GTAPHCPR 1384
Query: 400 SPQTDKPRQKMGKETFKDFQMA------QPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVA 453
P R+ +G + A P P+P++ EA S ++
Sbjct: 1385 LPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAK---------VDEATSGLIRELAAV 1435
Query: 454 QDTDDCDDFDISQLNLT-----PVTSTTPSTNSPPTPAP--------RQSSPSKSSASHA 500
+D ++ Q L P S T P AP + SP AS +
Sbjct: 1436 ED-------ELYQRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFS 1488
Query: 501 SDPTTDDIFEEGFESPSKS--EEQEAPDGSQASS--NSDPFGEPSGEP 544
SD DD E +S S Q+AP + A S ++ G P+ P
Sbjct: 1489 SDSPQDDTLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGTPASPP 1536
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,090,627
Number of Sequences: 37866
Number of extensions: 1450759
Number of successful extensions: 11028
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 95
Number of HSP's successfully gapped in prelim test: 687
Number of HSP's that attempted gapping in prelim test: 8215
Number of HSP's gapped (non-prelim): 2603
length of query: 555
length of database: 18,247,518
effective HSP length: 107
effective length of query: 448
effective length of database: 14,195,856
effective search space: 6359743488
effective search space used: 6359743488
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.