Search of human proteins with 31657138

Search of human proteins with 31657138

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31657138 follicle stimulating hormone receptor isoform 1
precursor [Homo sapiens]
         (695 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31657138 follicle stimulating hormone receptor isoform 1 prec...  1394   0.0  
gi|31657136 follicle stimulating hormone receptor isoform 2 prec...  1163   0.0  
gi|106067657 luteinizing hormone/choriogonadotropin receptor pre...   683   0.0  
gi|64085121 thyroid stimulating hormone receptor isoform 1 precu...   630   e-180
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   205   1e-52
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   201   2e-51
gi|62912472 leucine-rich repeat-containing G protein-coupled rec...   174   2e-43
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   174   2e-43
gi|62912474 leucine-rich repeat-containing G protein-coupled rec...   174   2e-43
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo...   157   3e-38
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo...   155   2e-37
gi|217330610 thyroid stimulating hormone receptor isoform 3 prec...   124   3e-28
gi|64085161 thyroid stimulating hormone receptor isoform 2 precu...   124   3e-28
gi|4505445 neuropeptide Y receptor Y1 [Homo sapiens]                   83   1e-15
gi|71999131 opsin 3 [Homo sapiens]                                     77   5e-14
gi|4557859 somatostatin receptor 2 [Homo sapiens]                      74   5e-13
gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens]              74   5e-13
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]            74   5e-13
gi|5174593 melatonin receptor 1A [Homo sapiens]                        74   6e-13
gi|4505447 neuropeptide Y receptor Y2 [Homo sapiens]                   74   6e-13
gi|51317373 netrin-G1 ligand [Homo sapiens]                            72   1e-12
gi|15150803 opsin 4 isoform 1 [Homo sapiens]                           72   2e-12
gi|5921992 adenosine A2a receptor [Homo sapiens]                       72   2e-12
gi|4506527 rhodopsin [Homo sapiens]                                    71   4e-12
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          70   9e-12
gi|4759146 slit homolog 2 [Homo sapiens]                               69   1e-11
gi|23238240 angiotensin II receptor, type 2 [Homo sapiens]             68   2e-11
gi|11321571 slit homolog 3 [Homo sapiens]                              68   3e-11
gi|157426873 tachykinin receptor 2 [Homo sapiens]                      67   4e-11
gi|188528675 slit homolog 1 [Homo sapiens]                             67   4e-11

>gi|31657138 follicle stimulating hormone receptor isoform 1
           precursor [Homo sapiens]
          Length = 695

 Score = 1394 bits (3609), Expect = 0.0
 Identities = 695/695 (100%), Positives = 695/695 (100%)

Query: 1   MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV 60
           MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV
Sbjct: 1   MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV 60

Query: 61  IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP 120
           IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP
Sbjct: 61  IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP 120

Query: 121 NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN 180
           NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN
Sbjct: 121 NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN 180

Query: 181 GIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLEN 240
           GIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLEN
Sbjct: 181 GIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLEN 240

Query: 241 LKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQE 300
           LKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQE
Sbjct: 241 LKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQE 300

Query: 301 VDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM 360
           VDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM
Sbjct: 301 VDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM 360

Query: 361 GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS 420
           GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS
Sbjct: 361 GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS 420

Query: 421 VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK 480
           VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK
Sbjct: 421 VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK 480

Query: 481 VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL 540
           VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL
Sbjct: 481 VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL 540

Query: 541 AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP 600
           AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP
Sbjct: 541 AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP 600

Query: 601 LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS 660
           LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS
Sbjct: 601 LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS 660

Query: 661 TVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN 695
           TVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN
Sbjct: 661 TVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN 695


>gi|31657136 follicle stimulating hormone receptor isoform 2
           precursor [Homo sapiens]
          Length = 633

 Score = 1163 bits (3008), Expect = 0.0
 Identities = 602/695 (86%), Positives = 612/695 (88%), Gaps = 62/695 (8%)

Query: 1   MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV 60
           MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV
Sbjct: 1   MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV 60

Query: 61  IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP 120
           IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP
Sbjct: 61  IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP 120

Query: 121 NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN 180
           NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN
Sbjct: 121 NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN 180

Query: 181 GIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLEN 240
           G                        ++E+ N  F+G                        
Sbjct: 181 G------------------------IQEIHNCAFNGTQ---------------------- 194

Query: 241 LKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQE 300
           L +L      NL++LP                +     A+    +SELHPICNKSILRQE
Sbjct: 195 LDELNLSDNNNLEELP----------------NDVFHGASGPVILSELHPICNKSILRQE 238

Query: 301 VDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM 360
           VDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM
Sbjct: 239 VDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM 298

Query: 361 GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS 420
           GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS
Sbjct: 299 GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS 358

Query: 421 VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK 480
           VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK
Sbjct: 359 VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK 418

Query: 481 VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL 540
           VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL
Sbjct: 419 VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL 478

Query: 541 AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP 600
           AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP
Sbjct: 479 AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP 538

Query: 601 LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS 660
           LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS
Sbjct: 539 LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS 598

Query: 661 TVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN 695
           TVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN
Sbjct: 599 TVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN 633


>gi|106067657 luteinizing hormone/choriogonadotropin receptor
           precursor [Homo sapiens]
          Length = 699

 Score =  683 bits (1763), Expect = 0.0
 Identities = 348/620 (56%), Positives = 459/620 (74%), Gaps = 13/620 (2%)

Query: 58  LRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQ 117
           ++VI   AF G  ++ KIEISQ D LE IEA+ F NL  L EI I+   NL YI P AF 
Sbjct: 61  VKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFI 120

Query: 118 NLPNLQYLLISNTGIKHLPDVHKIHSLQK-VLLDIQDNINIHTIERNSFVGLSFESVILW 176
           NLP L+YL I NTGI+  PDV K+ S +   +L+I DN++I TI  N+F G++ ESV L 
Sbjct: 121 NLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK 180

Query: 177 LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSY 236
           L  NG +E+ + AFNGT L  L L +N +LE++ N  F GA+GP  LDIS T++ +LPSY
Sbjct: 181 LYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSY 240

Query: 237 GLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSI 296
           GLE++++L A S+Y+LKKLP+ E  V L+EA+LTYPSHCCAF N   +        +++ 
Sbjct: 241 GLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENF 300

Query: 297 LRQEVDYMTQARGQR--SSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFN 354
            +Q    + +   +   SS+  ++E S   G+D     ++Y  C       C+P+PDAFN
Sbjct: 301 SKQCESTVRKVNNKTLYSSMLAESELS---GWD-----YEYGFCLPKTP-RCAPEPDAFN 351

Query: 355 PCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIY 414
           PCEDIMGY+ LRVLIW I+ILAI GN+ VL +L TS+YKLTVPRFLMCNL+FAD C+G+Y
Sbjct: 352 PCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLY 411

Query: 415 LLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHA 474
           LLLIASVD  TK QY+N+AIDWQTG+GC  AGFFTVFASELSVYTLT ITLERWHTIT+A
Sbjct: 412 LLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYA 471

Query: 475 MQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSL 534
           + LD K++LRHA  +M+ GW+F+   A+ P+ G+S+YMKVSIC PMD+++ LSQ+Y++++
Sbjct: 472 IHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTI 531

Query: 535 LVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAIS 594
           L+LNV+AF +IC CYI IY  VRNP +++++ DT+IAK+MA+LIFTDF CMAPISFFAIS
Sbjct: 532 LILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAIS 591

Query: 595 ASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIY 654
           A+ KVPLITV+ +K+LLVLF+PINSCANPFLYAIFTK F+RDFF+LLSK GC + +A++Y
Sbjct: 592 AAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELY 651

Query: 655 RTETSSTVHNTHPRNGHCSS 674
           R +  S  + ++ +NG   S
Sbjct: 652 RRKDFS-AYTSNCKNGFTGS 670


>gi|64085121 thyroid stimulating hormone receptor isoform 1
           precursor [Homo sapiens]
          Length = 764

 Score =  630 bits (1625), Expect = e-180
 Identities = 344/703 (48%), Positives = 453/703 (64%), Gaps = 53/703 (7%)

Query: 5   LVSLLAFLSL-----GSGCHHRICHCSNRV-FLCQESKVTEIPSDLPRNAIELRFVLTKL 58
           L+ L+  L L     G GC    C C     F      +  IPS LP +   L+ + T L
Sbjct: 6   LLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPS-LPPSTQTLKLIETHL 64

Query: 59  RVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQN 118
           R I   AFS   ++ +I +S +  L+ +E+  F NL K+  I I    NL YI+P+A + 
Sbjct: 65  RTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKE 124

Query: 119 LPNLQYLLISNTGIKHLPDVHKIHSLQKV-LLDIQDNINIHTIERNSFVGLSFESVILWL 177
           LP L++L I NTG+K  PD+ K++S     +L+I DN  + +I  N+F GL  E++ L L
Sbjct: 125 LPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKL 184

Query: 178 NKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGA-SGPVILDISRTRIHSLPSY 236
             NG   +   AFNGT+LD + L+ N  L  +  D F G  SGP +LD+S+T + +LPS 
Sbjct: 185 YNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSK 244

Query: 237 GLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPI-CNKS 295
           GLE+LK+L AR+T+ LKKLP     + L  A L+YPSHCCAF N ++    L  + CN+S
Sbjct: 245 GLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNES 304

Query: 296 IL-----RQEVDYMTQARGQR--------------SSLAED--NESSYSRGFDMTYTE-- 332
            +     R+ V+ +     Q                S  +D  N + Y   F+    E  
Sbjct: 305 SMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEII 364

Query: 333 --------------------FDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFI 372
                               +DY +C +  D+ C+PK D FNPCEDIMGY  LR+++WF+
Sbjct: 365 GFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFV 424

Query: 373 SILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNY 432
           S+LA+ GN+ VL+IL TS YKL VPRFLMCNLAFAD C+G+YLLLIASVD++T S+Y+N+
Sbjct: 425 SLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNH 484

Query: 433 AIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVM 492
           AIDWQTG GC+ AGFFTVFASELSVYTLT ITLERW+ IT AM+LD K++LRHA ++MV 
Sbjct: 485 AIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVG 544

Query: 493 GWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHI 552
           GW+  F  AL P+ GISSY KVSICLPMD ++PL+  Y++ +L LN++AFV++C CY+ I
Sbjct: 545 GWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKI 604

Query: 553 YLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLV 612
           Y+TVRNP       DT+IAKRMA+LIFTDF+CMAPISF+A+SA L  PLITVS +KILLV
Sbjct: 605 YITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLV 664

Query: 613 LFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYR 655
           LF+P+NSCANPFLYAIFTK F+RD FILLSK G  + QAQ YR
Sbjct: 665 LFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYR 707


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  205 bits (522), Expect = 1e-52
 Identities = 160/614 (26%), Positives = 280/614 (45%), Gaps = 73/614 (11%)

Query: 50  ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNL- 108
           EL F    + VI  GAF G   L  I +  N  L  +    F NL  LH + I  A+ + 
Sbjct: 252 ELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP-LSFVGNSAFHNLSDLHSLVIRGASMVQ 310

Query: 109 -------------LYINPEAFQNLPN--------LQYLLISNTGIKHLPDVHKIHSLQKV 147
                        L +      ++PN        L+ L +S   I+ LP  +  H+L+++
Sbjct: 311 QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEI 370

Query: 148 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLE 207
            L  Q N  I+ I+  +F GL     IL L++N I EIH+ AF                 
Sbjct: 371 SL--QRN-QIYQIKEGTFQGL-ISLRILDLSRNLIHEIHSRAF----------------- 409

Query: 208 ELPNDVFHGASGPVI-LDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALME 266
                      GP+  LD+S   + S P+ GL  L +L+    + LK+    +  V L  
Sbjct: 410 --------ATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRS 461

Query: 267 ASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGF 326
            S+ Y   CCAF  W          C+        D   Q      S+A++  ++ +   
Sbjct: 462 LSVPYAYQCCAF--WG---------CDSYANLNTEDNSLQDH----SVAQEKGTADAANV 506

Query: 327 DMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVI 386
             T    ++      + + C+P   AF PCE ++G  ++R+ +WFI ++A+  N++V++ 
Sbjct: 507 TSTLENEEHSQ----IIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILT 562

Query: 387 LTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAG 446
              S   L   +  +  ++ ++L +GIY  ++  +D  +  ++  + I W+TG+GC  AG
Sbjct: 563 TFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAG 622

Query: 447 FFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIF 506
           F  VF+SE +++ L   T+ER  +    M+      L+      ++ ++ A  A  FP+F
Sbjct: 623 FLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLF 682

Query: 507 GISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSS 566
               Y    +CLP       S  + ++L++LN LAF+++   Y  +Y  +   ++ S +S
Sbjct: 683 HRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDL-SENS 741

Query: 567 DTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLY 626
            + + K +A LIFT+ +   P++FF+ +  +    I+    K + ++F P+ +C NP LY
Sbjct: 742 QSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLY 801

Query: 627 AIFTKNFRRDFFIL 640
             F   F+ D+ +L
Sbjct: 802 VFFNPKFKEDWKLL 815



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 60/203 (29%), Positives = 105/203 (51%), Gaps = 23/203 (11%)

Query: 73  EKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGI 132
           + ++IS N++ ++ E D F N P L E+++   N+L +I+P+A   L  L+ L + N  +
Sbjct: 60  QALDISMNNITQLPE-DAFKNFPFLEELQLA-GNDLSFIHPKALSGLKELKVLTLQNNQL 117

Query: 133 KHLPD--VHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIH-NCA 189
           K +P   +  + +LQ + LD     +I ++  +SF GL  +   LWL+ N + E+  +  
Sbjct: 118 KTVPSEAIRGLSALQSLRLDAN---HITSVPEDSFEGL-VQLRHLWLDDNSLTEVPVHPL 173

Query: 190 FNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSY---GLENLKKLRA 246
            N   L  L L+  N +  +P+  F   S  V+L +   +I SL  +   GL+NL+ L  
Sbjct: 174 SNLPTLQALTLA-LNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232

Query: 247 RSTYN--------LKKLPTLEKL 261
              YN        +K LP+L++L
Sbjct: 233 --NYNNLGEFPQAIKALPSLKEL 253



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 39/142 (27%), Positives = 58/142 (40%), Gaps = 14/142 (9%)

Query: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEE 208
           LDI  N NI  +  ++F    F    L L  N +  IH  A +G +  ++    NN L+ 
Sbjct: 62  LDISMN-NITQLPEDAFKNFPFLEE-LQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119

Query: 209 LPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLR----------ARSTYNLKKLPTL 258
           +P++   G S    L +    I S+P    E L +LR              + L  LPTL
Sbjct: 120 VPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179

Query: 259 EKLVALMEASLTYPSHCCAFAN 280
           + L   +    + P    AF N
Sbjct: 180 QALTLALNKISSIPDF--AFTN 199


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  201 bits (510), Expect = 2e-51
 Identities = 163/630 (25%), Positives = 286/630 (45%), Gaps = 62/630 (9%)

Query: 57  KLRVIQKGAFSGFGDLEKIEISQNDVLEVIEA-DVFSNLPKL--HEIRI----EKA---- 105
           ++  + K  F G   LE ++++ N++ E   A    SNL +L  H   I    EKA    
Sbjct: 221 RIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGN 280

Query: 106 ----------NNLLYINPEAFQNLPNLQYLLISNTG-IKHLPDVH-------------KI 141
                     N + ++   AFQ+LP L+ L ++    I   PD+              +I
Sbjct: 281 PSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQI 340

Query: 142 HSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNK-----NGIQEIHNCAFNGT-QL 195
            SL + + +   N+ +  +  N    L   SV   L K     N I EI    F     L
Sbjct: 341 SSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSL 400

Query: 196 DELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKL 255
             LNL+ N      PN  F      + LD+S   + S P  GL  L  L+    + L+ L
Sbjct: 401 RSLNLAWNKIAIIHPN-AFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSL 459

Query: 256 PTLEKLVALMEASLTYPSHCCAFA---NWRRQISELHPICNKSI--LRQEVDYMTQARGQ 310
            + E    L    + Y   CCAF    N  +  ++ +   N S+  L ++   M QA+ +
Sbjct: 460 ISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDE 519

Query: 311 RSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIW 370
           R               +    +F+ DL   +  V CSP P  F PCE ++   ++R+ +W
Sbjct: 520 RD-------------LEDFLLDFEEDL-KALHSVQCSPSPGPFKPCEHLLDGWLIRIGVW 565

Query: 371 FISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYH 430
            I++LA+T N +V   +  S   ++  + L+  +A  ++  G+   ++A VD  T   + 
Sbjct: 566 TIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFA 625

Query: 431 NYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVM 490
            +   W+ G GC   GF ++FASE SV+ LT   LER  ++ ++ + + K        ++
Sbjct: 626 RHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVII 685

Query: 491 VMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYI 550
           ++  + A   A  P+ G S Y    +CLP+    P +  Y+++L++LN L F+++   Y 
Sbjct: 686 LLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYT 745

Query: 551 HIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKIL 610
            +Y  +   ++  +  D  + K +A+L+FT+ +   P++F + S+ + +  I+    K +
Sbjct: 746 KLYCNLDKGDL-ENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFI 804

Query: 611 LVLFHPINSCANPFLYAIFTKNFRRDFFIL 640
           L++  P+ +C NP LY +F  +F+ D   L
Sbjct: 805 LLVVVPLPACLNPLLYILFNPHFKEDLVSL 834



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 65/223 (29%), Positives = 103/223 (46%), Gaps = 39/223 (17%)

Query: 23  CHCS--NRVFL---CQESKVTEIPS---------DLPRNAI---------------ELRF 53
           CHC    R+ L   C +  ++E+PS         DL  N I               ELR 
Sbjct: 38  CHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRL 97

Query: 54  VLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINP 113
               L  I KGAF+G   L K+ + QN+ L  +  +   NL  L  +R++ AN++ Y+ P
Sbjct: 98  AGNALTYIPKGAFTGLYSL-KVLMLQNNQLRHVPTEALQNLRSLQSLRLD-ANHISYVPP 155

Query: 114 EAFQNLPNLQYLLISNTGIKHLP--DVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFE 171
             F  L +L++L + +  +  +P      + +LQ + L +     IH I   +F  LS  
Sbjct: 156 SCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALN---KIHHIPDYAFGNLS-S 211

Query: 172 SVILWLNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLEELPNDV 213
            V+L L+ N I  +    F+G   L+ L+L+  NNL+E P  +
Sbjct: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLN-YNNLDEFPTAI 253


>gi|62912472 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 2 [Homo sapiens]
          Length = 915

 Score =  174 bits (442), Expect = 2e-43
 Identities = 154/634 (24%), Positives = 277/634 (43%), Gaps = 49/634 (7%)

Query: 50  ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLL 109
           EL F    ++ I + AF G   L+ I    N + + +    F  LPKLH + +  A ++ 
Sbjct: 209 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 267

Query: 110 YINPEAFQNLPNLQYLLISNTGIKHLPD-----VHKIHSLQKVLLDIQDNINIHTIERNS 164
              P+  +   +L+ L ++  GI+ LP      + ++  L+     I++  ++H  ++  
Sbjct: 268 EF-PD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLE 325

Query: 165 FVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVIL 223
            +GL           N I EI    F+  + L  L+LS N  +  +  + F      V L
Sbjct: 326 EIGLQH---------NRIWEIGADTFSQLSSLQALDLSWNA-IRSIHPEAFSTLHSLVKL 375

Query: 224 DISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAF----- 278
           D++  ++ +LP  GL  L  L+ +    L +  + +    L    + Y   CC +     
Sbjct: 376 DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCAS 435

Query: 279 ---ANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDY 335
              A+ + +  +LH           +D    ++     LA   E+ Y +  D    E + 
Sbjct: 436 FFKASGQWEAEDLH-----------LDDEESSKRPLGLLARQAENHYDQDLDELQLEMED 484

Query: 336 DLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKL 394
              +    V CSP P  F PCE +     +R+ +W I +L++  N +++L +       L
Sbjct: 485 SKPHP--SVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPL 542

Query: 395 TVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASE 454
              +F++  +A A+   GI   L+ASVD  T  Q+  Y   W+TG GC A GF  V  SE
Sbjct: 543 PPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSE 602

Query: 455 LSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKV 514
            SV  LT   ++   +++          L    + ++     A  AA  P+  +  Y   
Sbjct: 603 ASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGAS 662

Query: 515 SICLPM--DIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAK 572
            +CLP       P +  + ++L+++N   F+V+ G YI +Y  +   +   +  D  + +
Sbjct: 663 PLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVR 721

Query: 573 RMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKN 632
            +A LIF D L   P++F + ++ L +  +T    K +L++  P+ +C NP LY +F  +
Sbjct: 722 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPH 781

Query: 633 FRRDFFILLSKCG-----CYEMQAQIYRTETSST 661
           FR D   L  + G      Y    ++ ++   ST
Sbjct: 782 FRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDST 815



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 68/249 (27%), Positives = 101/249 (40%), Gaps = 34/249 (13%)

Query: 50  ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLL 109
           ELR     L  I   AFSG   L KI + QN+ L  I A+    LP L  +R++   NL+
Sbjct: 42  ELRLSGNHLSHIPGQAFSGLYSL-KILMLQNNQLGGIPAEALWELPSLQSLRLDA--NLI 98

Query: 110 YINPE-------------------------AFQNLPNLQYLLISNTGIKHLPDVHKIHSL 144
            + PE                         A  NLP LQ + ++   I H+PD    +  
Sbjct: 99  SLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLT 158

Query: 145 QKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNN 204
             V+L + +N  I  +  +SF GL      L LN N +QE         +L EL    NN
Sbjct: 159 SLVVLHLHNN-RIQHLGTHSFEGL-HNLETLDLNYNKLQEFPVAIRTLGRLQELGF-HNN 215

Query: 205 NLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARS---TYNLKKLPTLEKL 261
           N++ +P   F G      +      I  +     + L KL   S     ++++ P L+  
Sbjct: 216 NIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGT 275

Query: 262 VALMEASLT 270
            +L   +LT
Sbjct: 276 TSLEILTLT 284



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 41/165 (24%), Positives = 63/165 (38%), Gaps = 30/165 (18%)

Query: 106 NNLLYINPEAFQNLPNLQYLLISNTGIKHLPD--------------------------VH 139
           NNL  + P  F +L  L+ L +S   + H+P                           + 
Sbjct: 24  NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALW 83

Query: 140 KIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELN 199
           ++ SLQ + LD      I  +   SF GLS     LWL+ N + EI   A N     +  
Sbjct: 84  ELPSLQSLRLDAN---LISLVPERSFEGLS-SLRHLWLDDNALTEIPVRALNNLPALQAM 139

Query: 200 LSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKL 244
               N +  +P+  F   +  V+L +   RI  L ++  E L  L
Sbjct: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNL 184



 Score = 29.6 bits (65), Expect = 9.8
 Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 2/71 (2%)

Query: 177 LNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPS 235
           L+ N + E+    F+  + L+EL LS  N+L  +P   F G     IL +   ++  +P+
Sbjct: 21  LSMNNLTELQPGLFHHLRFLEELRLS-GNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79

Query: 236 YGLENLKKLRA 246
             L  L  L++
Sbjct: 80  EALWELPSLQS 90


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  174 bits (442), Expect = 2e-43
 Identities = 154/634 (24%), Positives = 277/634 (43%), Gaps = 49/634 (7%)

Query: 50  ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLL 109
           EL F    ++ I + AF G   L+ I    N + + +    F  LPKLH + +  A ++ 
Sbjct: 261 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 319

Query: 110 YINPEAFQNLPNLQYLLISNTGIKHLPD-----VHKIHSLQKVLLDIQDNINIHTIERNS 164
              P+  +   +L+ L ++  GI+ LP      + ++  L+     I++  ++H  ++  
Sbjct: 320 EF-PD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLE 377

Query: 165 FVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVIL 223
            +GL           N I EI    F+  + L  L+LS N  +  +  + F      V L
Sbjct: 378 EIGLQH---------NRIWEIGADTFSQLSSLQALDLSWNA-IRSIHPEAFSTLHSLVKL 427

Query: 224 DISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAF----- 278
           D++  ++ +LP  GL  L  L+ +    L +  + +    L    + Y   CC +     
Sbjct: 428 DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCAS 487

Query: 279 ---ANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDY 335
              A+ + +  +LH           +D    ++     LA   E+ Y +  D    E + 
Sbjct: 488 FFKASGQWEAEDLH-----------LDDEESSKRPLGLLARQAENHYDQDLDELQLEMED 536

Query: 336 DLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKL 394
              +    V CSP P  F PCE +     +R+ +W I +L++  N +++L +       L
Sbjct: 537 SKPHP--SVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPL 594

Query: 395 TVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASE 454
              +F++  +A A+   GI   L+ASVD  T  Q+  Y   W+TG GC A GF  V  SE
Sbjct: 595 PPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSE 654

Query: 455 LSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKV 514
            SV  LT   ++   +++          L    + ++     A  AA  P+  +  Y   
Sbjct: 655 ASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGAS 714

Query: 515 SICLPM--DIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAK 572
            +CLP       P +  + ++L+++N   F+V+ G YI +Y  +   +   +  D  + +
Sbjct: 715 PLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVR 773

Query: 573 RMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKN 632
            +A LIF D L   P++F + ++ L +  +T    K +L++  P+ +C NP LY +F  +
Sbjct: 774 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPH 833

Query: 633 FRRDFFILLSKCG-----CYEMQAQIYRTETSST 661
           FR D   L  + G      Y    ++ ++   ST
Sbjct: 834 FRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDST 867



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 72/303 (23%), Positives = 113/303 (37%), Gaps = 60/303 (19%)

Query: 23  CHCSNRVFL----CQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEIS 78
           CHC     +    C E  ++ +P DL      L   +  L  +Q G F     LE++ +S
Sbjct: 39  CHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLS 98

Query: 79  -----------------------QNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPE- 114
                                  QN+ L  I A+    LP L  +R++   NL+ + PE 
Sbjct: 99  GNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDA--NLISLVPER 156

Query: 115 ------------------------AFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLD 150
                                   A  NLP LQ + ++   I H+PD    +    V+L 
Sbjct: 157 SFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLH 216

Query: 151 IQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELP 210
           + +N  I  +  +SF GL      L LN N +QE         +L EL    NNN++ +P
Sbjct: 217 LHNN-RIQHLGTHSFEGL-HNLETLDLNYNKLQEFPVAIRTLGRLQELGF-HNNNIKAIP 273

Query: 211 NDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARS---TYNLKKLPTLEKLVALMEA 267
              F G      +      I  +     + L KL   S     ++++ P L+   +L   
Sbjct: 274 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEIL 333

Query: 268 SLT 270
           +LT
Sbjct: 334 TLT 336


>gi|62912474 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 3 [Homo sapiens]
          Length = 828

 Score =  174 bits (442), Expect = 2e-43
 Identities = 154/634 (24%), Positives = 277/634 (43%), Gaps = 49/634 (7%)

Query: 50  ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLL 109
           EL F    ++ I + AF G   L+ I    N + + +    F  LPKLH + +  A ++ 
Sbjct: 122 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 180

Query: 110 YINPEAFQNLPNLQYLLISNTGIKHLPD-----VHKIHSLQKVLLDIQDNINIHTIERNS 164
              P+  +   +L+ L ++  GI+ LP      + ++  L+     I++  ++H  ++  
Sbjct: 181 EF-PD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLE 238

Query: 165 FVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVIL 223
            +GL           N I EI    F+  + L  L+LS N  +  +  + F      V L
Sbjct: 239 EIGLQH---------NRIWEIGADTFSQLSSLQALDLSWNA-IRSIHPEAFSTLHSLVKL 288

Query: 224 DISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAF----- 278
           D++  ++ +LP  GL  L  L+ +    L +  + +    L    + Y   CC +     
Sbjct: 289 DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCAS 348

Query: 279 ---ANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDY 335
              A+ + +  +LH           +D    ++     LA   E+ Y +  D    E + 
Sbjct: 349 FFKASGQWEAEDLH-----------LDDEESSKRPLGLLARQAENHYDQDLDELQLEMED 397

Query: 336 DLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKL 394
              +    V CSP P  F PCE +     +R+ +W I +L++  N +++L +       L
Sbjct: 398 SKPHP--SVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPL 455

Query: 395 TVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASE 454
              +F++  +A A+   GI   L+ASVD  T  Q+  Y   W+TG GC A GF  V  SE
Sbjct: 456 PPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSE 515

Query: 455 LSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKV 514
            SV  LT   ++   +++          L    + ++     A  AA  P+  +  Y   
Sbjct: 516 ASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGAS 575

Query: 515 SICLPM--DIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAK 572
            +CLP       P +  + ++L+++N   F+V+ G YI +Y  +   +   +  D  + +
Sbjct: 576 PLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVR 634

Query: 573 RMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKN 632
            +A LIF D L   P++F + ++ L +  +T    K +L++  P+ +C NP LY +F  +
Sbjct: 635 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPH 694

Query: 633 FRRDFFILLSKCG-----CYEMQAQIYRTETSST 661
           FR D   L  + G      Y    ++ ++   ST
Sbjct: 695 FRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDST 728



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 50/215 (23%), Positives = 84/215 (39%), Gaps = 52/215 (24%)

Query: 106 NNLLYINPEAFQNLPNLQYLLISNTGIKHLPD--------------------------VH 139
           NNL  + P  F +L  L+ L +S   + H+P                           + 
Sbjct: 33  NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALW 92

Query: 140 KIHSLQKVLLDIQ--------------------DNINIHTIERNSFVGLSFESVILWLNK 179
           ++ SLQ + L+                       N NI  I   +F+G      I + + 
Sbjct: 93  ELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYD- 151

Query: 180 NGIQEIHNCAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGL 238
           N IQ +   AF    +L  L+L+   +++E P+    G +   IL ++R  I  LPS   
Sbjct: 152 NPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMC 209

Query: 239 ENLKKLRA--RSTYNLKKLPTLEKLVALMEASLTY 271
           + L +LR    S   +++LP+L +   L E  L +
Sbjct: 210 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQH 244



 Score = 29.6 bits (65), Expect = 9.8
 Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 2/71 (2%)

Query: 177 LNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPS 235
           L+ N + E+    F+  + L+EL LS  N+L  +P   F G     IL +   ++  +P+
Sbjct: 30  LSMNNLTELQPGLFHHLRFLEELRLS-GNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88

Query: 236 YGLENLKKLRA 246
             L  L  L++
Sbjct: 89  EALWELPSLQS 99


>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
           sapiens]
          Length = 757

 Score =  157 bits (397), Expect = 3e-38
 Identities = 150/627 (23%), Positives = 283/627 (45%), Gaps = 96/627 (15%)

Query: 33  QESKVTEIPSDLPRNAIELRFVL---TKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEAD 89
           Q + + ++P D  +N  +L+ +     K+  I   AF G   L K+ +S N +   ++  
Sbjct: 134 QWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRIT-FLKPG 192

Query: 90  VFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKV-L 148
           VF +L +L  + IE  N+L  I+P  F  L +L  L++ N  +  LPD      + ++  
Sbjct: 193 VFEDLHRLEWLIIED-NHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHW 251

Query: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLE 207
           LD++ N +IH +   +F+  S  +V++ + KN I  ++   F   Q LDEL+L  N    
Sbjct: 252 LDLEGN-HIHNLRNLTFISCSNLTVLV-MRKNKINHLNENTFAPLQKLDELDLGSN---- 305

Query: 208 ELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEA 267
                                +I +LP    ++LK+L                     + 
Sbjct: 306 ---------------------KIENLPPLIFKDLKELS--------------------QL 324

Query: 268 SLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARG---QRSSLAEDNESSYSR 324
           +L+Y                 +PI  + I   + DY+ + +    +   ++   +  +  
Sbjct: 325 NLSY-----------------NPI--QKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRP 365

Query: 325 GFDMTYTEFD-YDLCNEVVDV-TCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNII 382
             ++++  F  +  C     V +C P  D  +  E+++   I RV +W +S +   GNI 
Sbjct: 366 LMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIF 425

Query: 383 VLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGC 442
           V+ +    + +  +    + +L  AD  +GIYL +I   D+  + +Y+ +A  W     C
Sbjct: 426 VICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 485

Query: 443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAAL 502
              G   + ++E+SV  LT +TLE++  I +  +     + R   +V+++ WI  F  A 
Sbjct: 486 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCR-TITVLILIWITGFIVAF 544

Query: 503 FPI----FGISSYMKVSICLPM---DIDSPLSQLYVMSL-LVLNVLAFVVICGCYIHIYL 554
            P+    F  + Y    +C P+   D +S  +Q+Y +++ L +N+ AF++I   Y  ++ 
Sbjct: 545 IPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFY 604

Query: 555 TVRNPNIVSS------SSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI-TVSKA 607
           +V    I ++        +  +AKR   ++FTD LC  PI      + L+V +  T++  
Sbjct: 605 SVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSW 664

Query: 608 KILLVLFHPINSCANPFLYAIFTKNFR 634
            ++ +L  PINS  NP LY + T+ F+
Sbjct: 665 VVIFIL--PINSALNPILYTLTTRPFK 689


>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
           sapiens]
          Length = 754

 Score =  155 bits (391), Expect = 2e-37
 Identities = 153/609 (25%), Positives = 279/609 (45%), Gaps = 62/609 (10%)

Query: 70  GDLEKIEISQNDV---------LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP 120
           GDL+ + +  N+V         +  +   VF    KL +I ++  N + +I+ +AF  L 
Sbjct: 127 GDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQH-NCIRHISRKAFFGLC 185

Query: 121 NLQYLLISNTGIKHL-PDVHK-IHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLN 178
           NLQ L +++  I  L P + K +H L  ++LD  DN  I  I +  F GL+    +  +N
Sbjct: 186 NLQILYLNHNCITTLRPGIFKDLHQLTWLILD--DN-PITRISQRLFTGLNSLFFLSMVN 242

Query: 179 KNGIQEIHN--CAFNGTQLDELNLSD--NNNLEELPNDVFHGASGPVILDISRTRIHSLP 234
            N ++ +    CA    Q+ +LN  D   N ++ L N  F       +L + R +I  +P
Sbjct: 243 -NYLEALPKQMCA----QMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297

Query: 235 SY---GLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPI 291
                 L+NL +L   S    +  P L K + L++  L   S+   + + + Q   L  +
Sbjct: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQ-KLNLSSNPLMYLH-KNQFESLKQL 355

Query: 292 CNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEF-DYDLCNEVVDVT-CSPK 349
            +  + R E+  +             N   +    ++++  F ++  C+    V  C P 
Sbjct: 356 QSLDLERIEIPNI-------------NTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPL 402

Query: 350 PDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADL 409
            D  +  ED++  NILR+ +W I+ +   GN+ V+ + +  + + T     +  L  AD 
Sbjct: 403 TDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADC 462

Query: 410 CIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWH 469
            +G+YL  +   DI  + QY  YA+ W     C   GF  + ++E+SV  LT +TLE++ 
Sbjct: 463 LMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFL 522

Query: 470 TITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPI-----FGISSYMKVSICLPMDIDS 524
            I      + +   R  + +++  W+  F  A+ P      FG + Y K  +C P+  D 
Sbjct: 523 VIVFPFS-NIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFG-NFYGKNGVCFPLYYDQ 580

Query: 525 PL---SQLYVMSL-LVLNVLAFVVICGCYIHIYLTVRNPNIVSS------SSDTRIAKRM 574
                S+ Y + + L +N+LAF++I   YI ++ +++   + ++        +  +A R 
Sbjct: 581 TEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRF 640

Query: 575 AMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFR 634
             ++F+D +C  P+    I +  +V  I  +    +++ F P+NS  NP LY + T  F+
Sbjct: 641 FFIVFSDAICWIPVFVVKILSLFRVE-IPDTMTSWIVIFFLPVNSALNPILYTLTTNFFK 699

Query: 635 RDFFILLSK 643
                LL K
Sbjct: 700 DKLKQLLHK 708


>gi|217330610 thyroid stimulating hormone receptor isoform 3
           precursor [Homo sapiens]
          Length = 274

 Score =  124 bits (311), Expect = 3e-28
 Identities = 83/227 (36%), Positives = 120/227 (52%), Gaps = 9/227 (3%)

Query: 5   LVSLLAFLSL-----GSGCHHRICHCSNRV-FLCQESKVTEIPSDLPRNAIELRFVLTKL 58
           L+ L+  L L     G GC    C C     F      +  IPS LP +   L+ + T L
Sbjct: 6   LLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPS-LPPSTQTLKLIETHL 64

Query: 59  RVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQN 118
           R I   AFS   ++ +I +S +  L+ +E+  F NL K+  I I    NL YI+P+A + 
Sbjct: 65  RTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKE 124

Query: 119 LPNLQYLLISNTGIKHLPDVHKIHSLQ-KVLLDIQDNINIHTIERNSFVGLSFESVILWL 177
           LP L++L I NTG+K  PD+ K++S     +L+I DN  + +I  N+F GL  E++ L L
Sbjct: 125 LPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKL 184

Query: 178 NKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGA-SGPVIL 223
             NG   +   AFNGT+LD + L+ N  L  +  D F G  SGP +L
Sbjct: 185 YNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLL 231


>gi|64085161 thyroid stimulating hormone receptor isoform 2
           precursor [Homo sapiens]
          Length = 253

 Score =  124 bits (311), Expect = 3e-28
 Identities = 83/227 (36%), Positives = 120/227 (52%), Gaps = 9/227 (3%)

Query: 5   LVSLLAFLSL-----GSGCHHRICHCSNRV-FLCQESKVTEIPSDLPRNAIELRFVLTKL 58
           L+ L+  L L     G GC    C C     F      +  IPS LP +   L+ + T L
Sbjct: 6   LLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPS-LPPSTQTLKLIETHL 64

Query: 59  RVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQN 118
           R I   AFS   ++ +I +S +  L+ +E+  F NL K+  I I    NL YI+P+A + 
Sbjct: 65  RTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKE 124

Query: 119 LPNLQYLLISNTGIKHLPDVHKIHSLQ-KVLLDIQDNINIHTIERNSFVGLSFESVILWL 177
           LP L++L I NTG+K  PD+ K++S     +L+I DN  + +I  N+F GL  E++ L L
Sbjct: 125 LPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKL 184

Query: 178 NKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGA-SGPVIL 223
             NG   +   AFNGT+LD + L+ N  L  +  D F G  SGP +L
Sbjct: 185 YNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLL 231


>gi|4505445 neuropeptide Y receptor Y1 [Homo sapiens]
          Length = 384

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 78/318 (24%), Positives = 126/318 (39%), Gaps = 37/318 (11%)

Query: 372 ISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHN 431
           + IL ++GN+ +++I+   +    V   L+ NL+F+DL + I  L    V        + 
Sbjct: 50  VIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV--------YT 101

Query: 432 YAIDWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVM 490
               W  G A C    F    +  +S+++L  I +ER   I +      +   RHA   +
Sbjct: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR--GWRPNNRHAYVGI 159

Query: 491 VMGWIFAFAAAL------------FPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLN 538
            + W+ A A++L            F    + +Y    +C            Y   LLVL 
Sbjct: 160 AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ 219

Query: 539 V---LAFVVICGCYIHIYLTVRN-------PNIVSSSSDTRIAKRMAMLIFTDFLCMAPI 588
               L F+ IC   I+I L  RN        N   SS   RI   +  ++    +C  P+
Sbjct: 220 YFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPL 279

Query: 589 SFFAISASLKVPLITVSKAKILLVLFH---PINSCANPFLYAIFTKNFRRDFFILLSKCG 645
           + F         +I      +L +L H    I++C NP  Y    KNF+RD     + C 
Sbjct: 280 TIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCD 339

Query: 646 CYEMQAQIYRTETSSTVH 663
            +  +   Y T   ST+H
Sbjct: 340 -FRSRDDDYETIAMSTMH 356


>gi|71999131 opsin 3 [Homo sapiens]
          Length = 402

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 37/315 (11%)

Query: 345 TCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNL 404
           T SP P  F+P      Y  L +L+  I +L +  N++VLV+    Q   T    L+ N+
Sbjct: 29  TLSPAP-LFSPGT----YERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNI 83

Query: 405 AFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAIT 464
           + +DL + ++ +    V              W T  GC   GF       +S+ TLT + 
Sbjct: 84  SLSDLLVSLFGVTFTFVSCLRNGWV------WDT-VGCVWDGFSGSLFGIVSIATLTVLA 136

Query: 465 LERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDI-- 522
            ER+  + HA  ++     R    +    W+++ A A  P+ G + Y+     L   +  
Sbjct: 137 YERYIRVVHARVINFSWAWRAITYI----WLYSLAWAGAPLLGWNRYILDVHGLGCTVDW 192

Query: 523 ---DSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSS----------SSDTR 569
              D+  S   +   L   V+   VI  CY HI  ++R    V              + +
Sbjct: 193 KSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDLQTIQVIKILKYEKK 252

Query: 570 IAKRMAMLIFTDFLCMAP---ISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLY 626
           +AK   ++IFT  +C  P   I F  ++    +   T+S   I+  LF   N+  NP +Y
Sbjct: 253 LAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTIS---IVSYLFAKSNTVYNPVIY 309

Query: 627 AIFTKNFRRDFFILL 641
               + FRR    LL
Sbjct: 310 VFMIRKFRRSLLQLL 324


>gi|4557859 somatostatin receptor 2 [Homo sapiens]
          Length = 369

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 71/328 (21%), Positives = 140/328 (42%), Gaps = 36/328 (10%)

Query: 329 TYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILT 388
           T+    +DL   VV    S + +   P  D+    +L  + + + I+ + GN +V+ ++ 
Sbjct: 13  TWLSIPFDLNGSVVSTNTSNQTE---PYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVIL 69

Query: 389 TSQYKLTVPRFLMCNLAFAD--LCIGIYLLLIASVDIHTKSQYHNYAIDWQTG-AGCDAA 445
                 T+    + NLA AD    +G+  L +    +H           W  G A C   
Sbjct: 70  RYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVH-----------WPFGKAICRVV 118

Query: 446 GFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGW---------IF 496
                     S++ LT ++++R+  + H ++     + R A  + +  W         I 
Sbjct: 119 MTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIM 178

Query: 497 AFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTV 556
            +A      +G SS    +I  P +  +  +   + + ++  ++   +IC CY+ I + V
Sbjct: 179 IYAGLRSNQWGRSS---CTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKV 235

Query: 557 RNPNI-VSSS----SDTRIAKRMAMLIFTDFLCMAPISFFAISA-SLKVPLITVSKAKI- 609
           ++  I V SS    S+ ++ + +++++     C  P   F +S+ S+ +      K    
Sbjct: 236 KSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFD 295

Query: 610 LLVLFHPINSCANPFLYAIFTKNFRRDF 637
            +V+    NSCANP LYA  + NF++ F
Sbjct: 296 FVVVLTYANSCANPILYAFLSDNFKKSF 323


>gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens]
          Length = 318

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 67/293 (22%), Positives = 130/293 (44%), Gaps = 32/293 (10%)

Query: 371 FISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYH 430
           FI + AI GN++V+ ++  +    T   + + +LA AD+ +G+ ++ +A V +      H
Sbjct: 21  FIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIV-VSLGITIH 79

Query: 431 NYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVM 490
            Y+  + T           +  +  S+ +L AI ++R+  +   ++       R     +
Sbjct: 80  FYSCLFMT--------CLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLAL 131

Query: 491 VMGWIFAFAAALFPIFG-----ISSYMKVSICLPMDIDSPLSQLYVM--SLLVLNVLAFV 543
            + W+ +F   L P+FG      S Y +    L     S +   Y++  S L    +  V
Sbjct: 132 GLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLV 191

Query: 544 VICGCYIHIYLTVRNPNI--VSSSSDT--------RIAKRMAMLIFTDFLCMAPISFF-- 591
           V+C  Y+ I+  +RN     +S+S +T        + AK + +++F   L   P+S    
Sbjct: 192 VMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINC 251

Query: 592 AISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKC 644
            I  + +VP + +     + +L    NS  NP +YA   K F+  + ++L  C
Sbjct: 252 IIYFNGEVPQLVL----YMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC 300


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 68/262 (25%), Positives = 115/262 (43%), Gaps = 55/262 (20%)

Query: 3   LLLVSLLAFLSLGSGCHHRICHCSNRV--FLCQESKVTEIPSDLPRNAIELRFVLTKLRV 60
           +L  ++ A  S G      +C CSN+    +C    ++E+P  +P N   L  +   +++
Sbjct: 30  ILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQM 89

Query: 61  IQK------------------------GAFSGFGDLEKIEI------------------- 77
           IQ                         GAF+G   L  +E+                   
Sbjct: 90  IQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKL 149

Query: 78  ----SQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIK 133
                +N+ +E I +  F+ +P L  + + +   L YI+  AF+ L NL+YL +    IK
Sbjct: 150 RELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIK 209

Query: 134 HLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG- 192
            +P++  +  L++  L++  N +   I   SF GLS     LW+  + +  I   AF+G 
Sbjct: 210 DMPNLTPLVGLEE--LEMSGN-HFPEIRPGSFHGLS-SLKKLWVMNSQVSLIERNAFDGL 265

Query: 193 TQLDELNLSDNNNLEELPNDVF 214
             L ELNL+ +NNL  LP+D+F
Sbjct: 266 ASLVELNLA-HNNLSSLPHDLF 286



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 37/108 (34%), Positives = 52/108 (48%), Gaps = 4/108 (3%)

Query: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLE 207
           L++ +N NI  I+ ++F  L    V L L +N I++I   AFNG   L+ L L DN  L 
Sbjct: 80  LNLMEN-NIQMIQADTFRHLHHLEV-LQLGRNSIRQIEVGAFNGLASLNTLELFDNW-LT 136

Query: 208 ELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKL 255
            +P+  F   S    L +    I S+PSY    +  L       LKKL
Sbjct: 137 VIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKL 184


>gi|5174593 melatonin receptor 1A [Homo sapiens]
          Length = 350

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 62/314 (19%), Positives = 137/314 (43%), Gaps = 32/314 (10%)

Query: 365 LRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIH 424
           L  ++ F  ++ I GN++V++ +  ++         + +LA ADL + IY   +  + I 
Sbjct: 30  LACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIF 89

Query: 425 TKSQYHNYAIDWQTG-AGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQL 483
                      W  G   C  +GF    +   S++ +T I + R+  I H+++ D     
Sbjct: 90  NNG--------WNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSS 141

Query: 484 RHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLA-F 542
           +++   +++ W+   AA L P     +               +S  Y ++++V + L   
Sbjct: 142 KNSLCYVLLIWLLTLAAVL-PNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPM 200

Query: 543 VVICGCYIHIYLTV----------RNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFA 592
           +++  CY+ I++ V          R P +        +   +  ++F   +C AP++F  
Sbjct: 201 IIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFA--ICWAPLNFIG 258

Query: 593 ISASLKVPLITVSKAKILLVLFHPI---NSCANPFLYAIFTKNFRRDF-FILLSKCGCYE 648
           ++ +     +     + L V  + +   NSC N  +Y +  +NFR+++  I++S C    
Sbjct: 259 LAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLC---- 314

Query: 649 MQAQIYRTETSSTV 662
             A+++  ++S+ V
Sbjct: 315 -TARVFFVDSSNDV 327


>gi|4505447 neuropeptide Y receptor Y2 [Homo sapiens]
          Length = 381

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 79/335 (23%), Positives = 143/335 (42%), Gaps = 35/335 (10%)

Query: 348 PKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFA 407
           P+P+  +  + I    +L +    I +L + GN +V+ ++   +   TV  F + NLA A
Sbjct: 36  PEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVA 95

Query: 408 DLCIGIYLLLIASVDIHTKSQYHNYAIDWQTG-AGCDAAGFFTVFASELSVYTLTAITLE 466
           DL +    L             +    +W+ G   C    +    A ++S  TLT I L+
Sbjct: 96  DLLVNTLCLPFTLT--------YTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALD 147

Query: 467 RWHTITHAMQLDCKVQLRHAASVMVMGW-IFAFAAALFPIFGISSYM------KVSICL- 518
           R   I +   L+ K+  R +  ++ + W I A  A+   IF   S +      ++  C  
Sbjct: 148 RHRCIVY--HLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTE 205

Query: 519 --PMDIDSPLSQLY-VMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSD------TR 569
             P +  S    +Y + SLL+L VL   +I   Y  I+  ++N     +++D       +
Sbjct: 206 KWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQK 265

Query: 570 IAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSC---ANPFLY 626
             K +  ++    +   P+  F ++  +   ++ + + K++  +FH I  C   ANP LY
Sbjct: 266 TTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLY 325

Query: 627 AIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSST 661
                N+R+ F   LS   C E +     +E S T
Sbjct: 326 GWMNSNYRKAF---LSAFRC-EQRLDAIHSEVSVT 356


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 55/243 (22%)

Query: 22  ICHCSNRV--FLCQESKVTEIPS---------DLPRNAIE---------------LRFVL 55
           +C CSN+    +C    + E+P          +L  N I+               L+   
Sbjct: 50  VCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSR 109

Query: 56  TKLRVIQKGAFSGFGDLEKIEIS-----------------------QNDVLEVIEADVFS 92
             +R I+ GAF+G  +L  +E+                        +N+ +E I +  F+
Sbjct: 110 NHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFN 169

Query: 93  NLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQ 152
            +P L  + + +   L YI+  AF+ L NL+YL ++   ++ +P++  +  L +  LD+ 
Sbjct: 170 RIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDE--LDLS 227

Query: 153 DNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLEELPN 211
            N ++  I   SF GL      LW+ ++ IQ I   AF+  Q L E+NL+ +NNL  LP+
Sbjct: 228 GN-HLSAIRPGSFQGL-MHLQKLWMIQSQIQVIERNAFDNLQSLVEINLA-HNNLTLLPH 284

Query: 212 DVF 214
           D+F
Sbjct: 285 DLF 287



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 44/124 (35%), Positives = 59/124 (47%), Gaps = 4/124 (3%)

Query: 133 KHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG 192
           K+L +V    S    LL++ +N  I  I+ NSF  L     IL L++N I+ I   AFNG
Sbjct: 65  KNLREVPDGISTNTRLLNLHEN-QIQIIKVNSFKHLRHLE-ILQLSRNHIRTIEIGAFNG 122

Query: 193 -TQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYN 251
              L+ L L DN  L  +PN  F   S    L +    I S+PSY    +  LR      
Sbjct: 123 LANLNTLELFDNR-LTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGE 181

Query: 252 LKKL 255
           LK+L
Sbjct: 182 LKRL 185


>gi|15150803 opsin 4 isoform 1 [Homo sapiens]
          Length = 478

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 69/293 (23%), Positives = 118/293 (40%), Gaps = 30/293 (10%)

Query: 365 LRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIH 424
           L  +I  + +  + GN+ V+     S+   T     + NLA +D     +L+      + 
Sbjct: 73  LGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSD-----FLMSFTQAPVF 127

Query: 425 TKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLR 484
             S  +   +  +TG  C+   F        S+ TLTAI L+R+  IT  +        R
Sbjct: 128 FTSSLYKQWLFGETG--CEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKR 185

Query: 485 HAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDID----SPLSQLYVMSL-LVLNV 539
            AA V++  W++A A +L P FG S+Y+   +      D    +P  + Y M L   +  
Sbjct: 186 RAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFF 245

Query: 540 LAFVVICGCYIHIYLTVRNPNIVSSS------------------SDTRIAKRMAMLIFTD 581
           L  ++I  CYI I+  +R       +                  S+ ++AK M ++I   
Sbjct: 246 LPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLF 305

Query: 582 FLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFR 634
            L  AP S  A+ A      +       +  +    ++  NP +YAI    +R
Sbjct: 306 VLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 358


>gi|5921992 adenosine A2a receptor [Homo sapiens]
          Length = 412

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 79/350 (22%), Positives = 148/350 (42%), Gaps = 59/350 (16%)

Query: 359 IMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLI 418
           IMG ++   +   I++LAI GN++V   +  +     V  + + +LA AD+ +G+  +  
Sbjct: 3   IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI-- 60

Query: 419 ASVDIHTKSQYHNYAIDWQTGA-----GCDAAGFFTVFASELSVYTLTAITLERWHTITH 473
                        +AI   TG      GC     F +  ++ S+++L AI ++R+  I  
Sbjct: 61  ------------PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRI 108

Query: 474 AMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVS--------------ICLP 519
            ++ +  V    A  ++ + W+ +FA  L P+ G ++  +                 CL 
Sbjct: 109 PLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLF 168

Query: 520 MDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRN----------PNIVSSSS--- 566
            D+  P++ +   +     ++  +++ G Y+ I+L  R           P   + S+   
Sbjct: 169 EDV-VPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQK 227

Query: 567 DTRIAKRMAMLIFTDFLCMAPI------SFFAISASLKVPLITVSKAKILLVLFHPINSC 620
           +   AK +A+++    LC  P+      +FF    S   PL  +  A   +VL H  NS 
Sbjct: 228 EVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCS-HAPLWLMYLA---IVLSH-TNSV 282

Query: 621 ANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNG 670
            NPF+YA   + FR+ F  ++ +      Q       TS+ V   H  +G
Sbjct: 283 VNPFIYAYRIREFRQTFRKII-RSHVLRQQEPFKAAGTSARVLAAHGSDG 331


>gi|4506527 rhodopsin [Homo sapiens]
          Length = 348

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 66/321 (20%), Positives = 132/321 (41%), Gaps = 37/321 (11%)

Query: 362 YNILRVLIWFISILAITGNIIVLVILTTSQYKLTVP-RFLMCNLAFADLCIGIYLLLIAS 420
           +++L   ++ + +L    N + L + T    KL  P  +++ NLA ADL      +++  
Sbjct: 37  FSMLAAYMFLLIVLGFPINFLTLYV-TVQHKKLRTPLNYILLNLAVADL-----FMVLGG 90

Query: 421 VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK 480
                 +  H Y +   TG  C+  GFF     E+++++L  + +ER+  +   M  + +
Sbjct: 91  FTSTLYTSLHGYFVFGPTG--CNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMS-NFR 147

Query: 481 VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDID------SPLSQLYVMSL 534
               HA   +   W+ A A A  P+ G S Y+   +     ID         ++ +V+ +
Sbjct: 148 FGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYM 207

Query: 535 LVLN-VLAFVVICGCYIHIYLTVR------NPNIVSSSSDTRIAKRMAMLIFTDFLCMAP 587
            V++  +  ++I  CY  +  TV+        +  +  ++  + + + +++    +C  P
Sbjct: 208 FVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVP 267

Query: 588 IS-----FFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILL- 641
            +      F    S   P+     A      F    +  NP +Y +  K FR      + 
Sbjct: 268 YASVAFYIFTHQGSNFGPIFMTIPA-----FFAKSAAIYNPVIYIMMNKQFRNCMLTTIC 322

Query: 642 ---SKCGCYEMQAQIYRTETS 659
              +  G  E  A + +TETS
Sbjct: 323 CGKNPLGDDEASATVSKTETS 343


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 64/242 (26%), Positives = 108/242 (44%), Gaps = 55/242 (22%)

Query: 23  CHCSNRV--FLCQESKVTEIPSDLP---------RNAIE---------------LRFVLT 56
           C CSN+    +C    + E+P+ +P          N I+               L+    
Sbjct: 61  CSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKN 120

Query: 57  KLRVIQKGAFSGFGDLEKIEIS-----------------------QNDVLEVIEADVFSN 93
            +R I+ GAF+G   L  +E+                        +N+ +E I +  F+ 
Sbjct: 121 LVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNR 180

Query: 94  LPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQD 153
           +P L  + + +   L YI+  AF+ L NL+YL +    +K +P++  +  L++  L++  
Sbjct: 181 VPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEE--LELSG 238

Query: 154 NINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLEELPND 212
           N  +  I   SF GL+     LWL    +  I   AF+  + L+ELNLS +NNL  LP+D
Sbjct: 239 N-RLDLIRPGSFQGLT-SLRKLWLMHAQVATIERNAFDDLKSLEELNLS-HNNLMSLPHD 295

Query: 213 VF 214
           +F
Sbjct: 296 LF 297



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 37/108 (34%), Positives = 52/108 (48%), Gaps = 4/108 (3%)

Query: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNLE 207
           L++Q+N  I  I  ++F  L     IL L+KN +++I   AFNG   L+ L L DN  L 
Sbjct: 91  LNLQEN-GIQVIRTDTFKHLRHLE-ILQLSKNLVRKIEVGAFNGLPSLNTLELFDNR-LT 147

Query: 208 ELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKL 255
            +P   F   S    L +    I S+PSY    +  LR      LK+L
Sbjct: 148 TVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRL 195



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 23/95 (24%), Positives = 42/95 (44%), Gaps = 10/95 (10%)

Query: 177 LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSY 236
           L +NGIQ I    F   +  E+     N + ++    F+G      L++   R+ ++P+ 
Sbjct: 93  LQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQ 152

Query: 237 GLENLKKLR----------ARSTYNLKKLPTLEKL 261
             E L KLR          +  +Y   ++P+L +L
Sbjct: 153 AFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRL 187


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 13/148 (8%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C CSN +  C+   +TEIP++LP    E+R     ++VI  GAFS +  L +I++S N +
Sbjct: 277 CTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQI 336

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHL-----PD 137
            E +  D F  L  L+ + +   N +  +    F+ L +LQ LL++   I  L      D
Sbjct: 337 SE-LAPDAFQGLRSLNSL-VLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQD 394

Query: 138 VHKIHSLQKVLLDIQDNINIHTIERNSF 165
           +H ++     LL + DN  + TI + +F
Sbjct: 395 LHNLN-----LLSLYDN-KLQTIAKGTF 416



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 49/184 (26%), Positives = 78/184 (42%), Gaps = 7/184 (3%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C CS     C    +  +P ++PRN   L      +  I K  F+G   L  +++ +N +
Sbjct: 32  CSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKI 91

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPE-AFQNLPNLQYLLISNTGIKHLPDVHKI 141
              IE   F +L +L  +R+ +  N L + PE  F     L  L +S   I+ +P     
Sbjct: 92  -STIERGAFQDLKELERLRLNR--NHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFR 148

Query: 142 HSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNL 200
            ++    L +  N  I  IE  +F  L  +  +L LN N I  +   +FN   +L    L
Sbjct: 149 GAVDIKNLQLDYN-QISCIEDGAFRALR-DLEVLTLNNNNITRLSVASFNHMPKLRTFRL 206

Query: 201 SDNN 204
             NN
Sbjct: 207 HSNN 210



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 4/144 (2%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQ-KGAFSGFGDLEKIEISQND 81
           C C      C   K+ +IP  +P+   ELR    +  V++  G F     L KI  S N 
Sbjct: 510 CRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNK 569

Query: 82  VLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKI 141
           + + IE   F     ++EI +  +N L  +  + F+ L +L+ L++ +  I  + +   I
Sbjct: 570 ITD-IEEGAFEGASGVNEILL-TSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFI 627

Query: 142 HSLQKVLLDIQDNINIHTIERNSF 165
                 LL + DN  I T+   +F
Sbjct: 628 GLSSVRLLSLYDN-QITTVAPGAF 650



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 3/115 (2%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C C + V  C    +  +P  +PR+  EL     +  ++ K   S +  L  I++S N +
Sbjct: 731 CTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLTLIDLSNNRI 789

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 137
              +    FSN+ +L  + I   N L  I P  F  L +L+ L +    I  +P+
Sbjct: 790 -STLSNQSFSNMTQLLTL-ILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPE 842



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 30/87 (34%), Positives = 44/87 (50%), Gaps = 4/87 (4%)

Query: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNLE 207
           LD+  N NI  I +  F GL    V L L +N I  I   AF    +L+ L L+  N+L+
Sbjct: 60  LDLNGN-NITRITKTDFAGLRHLRV-LQLMENKISTIERGAFQDLKELERLRLN-RNHLQ 116

Query: 208 ELPNDVFHGASGPVILDISRTRIHSLP 234
             P  +F G +    LD+S  +I ++P
Sbjct: 117 LFPELLFLGTAKLYRLDLSENQIQAIP 143



 Score = 33.5 bits (75), Expect = 0.68
 Identities = 32/121 (26%), Positives = 49/121 (40%), Gaps = 7/121 (5%)

Query: 177 LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSY 236
           L+ N I E+   AF G +     +   N + ELP  +F G     +L ++  +I+ L   
Sbjct: 331 LSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 390

Query: 237 GLENLKKLRARSTYNLKKLPTLEK-----LVALMEASLTY-PSHCCAFANWRRQISELHP 290
             ++L  L   S Y+  KL T+ K     L A+    L   P  C     W       +P
Sbjct: 391 AFQDLHNLNLLSLYD-NKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNP 449

Query: 291 I 291
           I
Sbjct: 450 I 450



 Score = 29.6 bits (65), Expect = 9.8
 Identities = 32/137 (23%), Positives = 52/137 (37%), Gaps = 15/137 (10%)

Query: 178 NKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYG 237
           + N I +I   AF G       L  +N LE + + +F G      L +   RI  + +  
Sbjct: 566 SNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDS 625

Query: 238 LENLKKLRARSTYNLK-------KLPTLEKLVALMEASLTYPSHCCAFANW------RRQ 284
              L  +R  S Y+ +          TL  L  L    L  P +C  +  W      +++
Sbjct: 626 FIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTL--NLLANPFNCNCYLAWLGEWLRKKR 683

Query: 285 ISELHPICNKSILRQEV 301
           I   +P C K    +E+
Sbjct: 684 IVTGNPRCQKPYFLKEI 700


>gi|23238240 angiotensin II receptor, type 2 [Homo sapiens]
          Length = 363

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 70/318 (22%), Positives = 132/318 (41%), Gaps = 39/318 (12%)

Query: 339 NEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPR 398
           N    + CS KP   +        + + +L + I ++    NI+V+ +    +    V  
Sbjct: 28  NNESTLNCSQKPSDKH-------LDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSS 80

Query: 399 FLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTG-AGCDAAGFFTVFASELSV 457
             + NLA ADL      LL+A++ +   + Y++Y  DW  G   C   G F       S+
Sbjct: 81  IYIFNLAVADL------LLLATLPLW--ATYYSYRYDWLFGPVMCKVFGSFLTLNMFASI 132

Query: 458 YTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISS-----YM 512
           + +T ++++R+ ++ +   L  +     A+ ++ + W  A  ++L P F         Y+
Sbjct: 133 FFITCMSVDRYQSVIYPF-LSQRRNPWQASYIVPLVWCMACLSSL-PTFYFRDVRTIEYL 190

Query: 513 KVSICLPMDIDSPLSQLYVMSLLVLNVLAFVV----ICGCYIHIYLTVRNPNIVSSSSDT 568
            V+ C+        +Q      L+ N+L F++    I  CY  I   +   N    +  T
Sbjct: 191 GVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRIT 250

Query: 569 R--IAKRMAMLIFTDFLCMAP---------ISFFAISASLKVPLITVSKAKILLVLFHPI 617
           R  + K  A ++    +C  P         +++  +  S +V +  +  A    +L    
Sbjct: 251 RDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEV-IAVIDLALPFAILLGFT 309

Query: 618 NSCANPFLYAIFTKNFRR 635
           NSC NPFLY      F++
Sbjct: 310 NSCVNPFLYCFVGNRFQQ 327


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 47/147 (31%), Positives = 75/147 (51%), Gaps = 5/147 (3%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C CSN +  C+   + EIP++LP   +E+R     ++ I  GAF+ +  L++I+IS+N +
Sbjct: 284 CTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQI 343

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIH 142
            + I  D F  L  L  + +   N +  I    F  L +LQ LL++   I  L  V+   
Sbjct: 344 SD-IAPDAFQGLKSLTSL-VLYGNKITEIAKGLFDGLVSLQLLLLNANKINCL-RVNTFQ 400

Query: 143 SLQKV-LLDIQDNINIHTIERNSFVGL 168
            LQ + LL + DN  + TI +  F  L
Sbjct: 401 DLQNLNLLSLYDN-KLQTISKGLFAPL 426



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 55/175 (31%), Positives = 79/175 (45%), Gaps = 16/175 (9%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C CS     C    +  +P  +PRNA  L      +  I K  F+G  +L  + +  N V
Sbjct: 38  CTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQV 97

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPE-AFQNLPNLQYLLISNTGIKHLP----- 136
             VIE   F +L +L  +R+ K  N L + PE  FQ+ P L  L +S   I+ +P     
Sbjct: 98  -SVIERGAFQDLKQLERLRLNK--NKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFR 154

Query: 137 DVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFN 191
            +  + +LQ       DN +I  IE  +F  L  +  IL LN N I  I   +FN
Sbjct: 155 GITDVKNLQ------LDNNHISCIEDGAFRALR-DLEILTLNNNNISRILVTSFN 202



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 42/153 (27%), Positives = 66/153 (43%), Gaps = 4/153 (2%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQ-KGAFSGFGDLEKIEISQND 81
           C C   +  C   K+  IPS LP    +LR    ++ V++  G F    +L KI +S N 
Sbjct: 509 CRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNK 568

Query: 82  VLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKI 141
           + EV E   F     + E+ +   N L  ++   F+ L  L+ L++ +  I  + +    
Sbjct: 569 IKEVREG-AFDGAASVQELML-TGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFA 626

Query: 142 HSLQKVLLDIQDNINIHTIERNSFVGLSFESVI 174
                 LL + DN  I TI   +F  L   S I
Sbjct: 627 GLSSVRLLSLYDN-RITTITPGAFTTLVSLSTI 658



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 29/115 (25%), Positives = 48/115 (41%), Gaps = 3/115 (2%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C C   V  C    +  +P  +P++  EL      L  + +   S    L  I++S N +
Sbjct: 729 CTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR-ELSALRHLTLIDLSNNSI 787

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 137
             ++    FSN+  L  + I   N L  I   AF  L +L+ L +    I  +P+
Sbjct: 788 -SMLTNYTFSNMSHLSTL-ILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE 840



 Score = 36.6 bits (83), Expect = 0.081
 Identities = 35/137 (25%), Positives = 59/137 (43%), Gaps = 13/137 (9%)

Query: 177 LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSY 236
           L+ N I+E+   AF+G    +  +   N LE +   VF G SG   L +    I  + + 
Sbjct: 564 LSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSND 623

Query: 237 GLENLKKLRARSTYNLKKLPTL-----EKLVALMEAS-LTYPSHCCAFANW------RRQ 284
               L  +R  S Y+  ++ T+       LV+L   + L+ P +C     W      +R+
Sbjct: 624 TFAGLSSVRLLSLYD-NRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRR 682

Query: 285 ISELHPICNKSILRQEV 301
           I   +P C K    +E+
Sbjct: 683 IVSGNPRCQKPFFLKEI 699



 Score = 34.7 bits (78), Expect = 0.31
 Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 7/101 (6%)

Query: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNLE 207
           LD+  N NI  I +  F GL     +L L  N +  I   AF    QL+ L L+  N L+
Sbjct: 66  LDLDRN-NITRITKMDFAGLK-NLRVLHLEDNQVSVIERGAFQDLKQLERLRLN-KNKLQ 122

Query: 208 ELPNDVFHGASGPVILDISRTRIHSLPS---YGLENLKKLR 245
            LP  +F        LD+S  +I  +P     G+ ++K L+
Sbjct: 123 VLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQ 163


>gi|157426873 tachykinin receptor 2 [Homo sapiens]
          Length = 398

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 66/290 (22%), Positives = 117/290 (40%), Gaps = 28/290 (9%)

Query: 374 ILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYA 433
           ++A+TGN IV+ I+   +   TV  + + NLA ADLC+  +      V       Y ++ 
Sbjct: 45  LVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFV-------YASHN 97

Query: 434 IDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMG 493
           I +   A C     F + A  +S+Y++TAI  +R+  I H  Q   ++      +V+   
Sbjct: 98  IWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAGI 155

Query: 494 WIFAFAAALFPIFGISSYM-----KVSICLPMDIDSPLSQLY-VMSLLVLNVLAFVVICG 547
           W+ A A A    F  +  M     K  +  P D       LY ++ + ++  L   V+  
Sbjct: 156 WLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFV 215

Query: 548 CYIHIYLTV----------RNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASL 597
            Y  I LT+             N+    +  +  K M +++ T  +C  P   + I  S 
Sbjct: 216 AYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSF 275

Query: 598 KVPLIT---VSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKC 644
           +  +     + +  + L      ++  NP +Y      FR  F +    C
Sbjct: 276 QEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCC 325


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 50/158 (31%), Positives = 79/158 (50%), Gaps = 7/158 (4%)

Query: 13  SLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDL 72
           +L SG    +C CSN +  C+   +T IP++LP    E+R  L  ++ I  GAFS +  L
Sbjct: 276 TLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKL 335

Query: 73  EKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGI 132
            +I++S N + E I  D F  L  L+ + +   N +  +    F  L  LQ LL++   I
Sbjct: 336 RRIDLSNNQIAE-IAPDAFQGLRSLNSL-VLYGNKITDLPRGVFGGLYTLQLLLLNANKI 393

Query: 133 KHL-PDVHKIHSLQKV-LLDIQDNINIHTIERNSFVGL 168
             + PD      LQ + LL + DN  I ++ + +F  L
Sbjct: 394 NCIRPDA--FQDLQNLSLLSLYDN-KIQSLAKGTFTSL 428



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 8/191 (4%)

Query: 3   LLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQ 62
           L L+   A   LG+     +C C+     C  + +  IP ++PRN   L      +  I 
Sbjct: 18  LWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIH 77

Query: 63  KGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPE-AFQNLPN 121
           K  F+G   L  +++ +N +   +E   F ++ +L  +R+ +  N L++ PE  FQN   
Sbjct: 78  KNDFAGLKQLRVLQLMENQI-GAVERGAFDDMKELERLRLNR--NQLHMLPELLFQNNQA 134

Query: 122 LQYLLISNTGIKHLPDVHKIHSLQKVLLDIQ-DNINIHTIERNSFVGLSFESVILWLNKN 180
           L  L +S   I+ +P   K       L ++Q D   I  IE  +F  L    V L LN N
Sbjct: 135 LSRLDLSENAIQAIP--RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEV-LTLNNN 191

Query: 181 GIQEIHNCAFN 191
            I  I   +FN
Sbjct: 192 NITTIPVSSFN 202



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 7/150 (4%)

Query: 18  CHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQ-KGAFSGFGDLEKIE 76
           C H+ C C   V  C   K+T+IP  +P++  ELR    ++ +++  G F     L+KI 
Sbjct: 513 CPHK-CRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571

Query: 77  ISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLP 136
           +S N V E IE   F     + E+ +  AN L  I    F+ L  L+ L++ N  I  + 
Sbjct: 572 LSNNKVSE-IEDGAFEGAASVSELHL-TANQLESIRSGMFRGLDGLRTLMLRNNRISCIH 629

Query: 137 DVHKIHSLQKV-LLDIQDNINIHTIERNSF 165
           +      L+ V LL + DN  I T+   +F
Sbjct: 630 N-DSFTGLRNVRLLSLYDN-QITTVSPGAF 657



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 3/115 (2%)

Query: 23  CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 82
           C C + V  C    +  +P  +P+N  EL     +  ++  G  S F  L+ +++S N +
Sbjct: 738 CACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLV-PGQLSTFKYLQLVDLSNNKI 796

Query: 83  LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 137
             +  +  F+N+ +L  + I   N L  I P AFQ L +L+ L +    I  L +
Sbjct: 797 SSLSNSS-FTNMSQLTTL-ILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQE 849



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 32/101 (31%), Positives = 49/101 (48%), Gaps = 7/101 (6%)

Query: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNLE 207
           L++  N NI  I +N F GL  +  +L L +N I  +   AF+   +L+ L L+  N L 
Sbjct: 66  LELNGN-NITRIHKNDFAGLK-QLRVLQLMENQIGAVERGAFDDMKELERLRLN-RNQLH 122

Query: 208 ELPNDVFHGASGPVILDISRTRIHSLPS---YGLENLKKLR 245
            LP  +F        LD+S   I ++P     G  +LK L+
Sbjct: 123 MLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQ 163



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 37/141 (26%), Positives = 61/141 (43%), Gaps = 8/141 (5%)

Query: 118 NLPN-LQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGL-SFESVIL 175
           NLP  +  + +   GIK +P        +   +D+ +N  I  I  ++F GL S  S++L
Sbjct: 306 NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNN-QIAEIAPDAFQGLRSLNSLVL 364

Query: 176 WLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPS 235
           + NK  I ++    F G    +L L + N +  +  D F       +L +   +I SL  
Sbjct: 365 YGNK--ITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAK 422

Query: 236 YGLENLKKLRARSTYNLKKLP 256
                   LRA  T +L + P
Sbjct: 423 ---GTFTSLRAIQTLHLAQNP 440



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 4/59 (6%)

Query: 193 TQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPS---YGLENLKKLRARS 248
           T L ++NLS NN + E+ +  F GA+    L ++  ++ S+ S    GL+ L+ L  R+
Sbjct: 565 THLKKINLS-NNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRN 622


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.138    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,856,075
Number of Sequences: 37866
Number of extensions: 994953
Number of successful extensions: 5171
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 281
Number of HSP's successfully gapped in prelim test: 415
Number of HSP's that attempted gapping in prelim test: 3639
Number of HSP's gapped (non-prelim): 1203
length of query: 695
length of database: 18,247,518
effective HSP length: 109
effective length of query: 586
effective length of database: 14,120,124
effective search space: 8274392664
effective search space used: 8274392664
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.