Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 211971072
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|211971072 FERM and PDZ domain containing 4 [Homo sapiens]
(1322 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|211971072 FERM and PDZ domain containing 4 [Homo sapiens] 2631 0.0
gi|89060961 PREDICTED: FERM and PDZ domain containing 3 [Homo sa... 511 e-144
gi|89059963 PREDICTED: FERM and PDZ domain containing 3 [Homo sa... 511 e-144
gi|239582741 FERM and PDZ domain containing 1 [Homo sapiens] 457 e-128
gi|239757877 PREDICTED: FERM and PDZ domain containing 3 [Homo s... 351 2e-96
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 69 4e-11
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 69 4e-11
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 62 3e-09
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 62 3e-09
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 62 3e-09
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 62 3e-09
gi|223029410 talin 1 [Homo sapiens] 57 2e-07
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 54 1e-06
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 54 1e-06
gi|10092691 tight junction protein 3 [Homo sapiens] 54 1e-06
gi|161016767 mucin 21 [Homo sapiens] 54 1e-06
gi|38788333 remodeling and spacing factor 1 [Homo sapiens] 52 5e-06
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 50 1e-05
gi|4759306 lin-7 homolog A [Homo sapiens] 50 2e-05
gi|112382257 InaD-like [Homo sapiens] 49 3e-05
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 48 5e-05
gi|148746189 multiple PDZ domain protein [Homo sapiens] 48 7e-05
gi|156938343 talin 2 [Homo sapiens] 47 2e-04
gi|42794779 myosin 18A isoform b [Homo sapiens] 46 2e-04
gi|28416946 myosin 18A isoform a [Homo sapiens] 46 2e-04
gi|157738639 tensin 4 [Homo sapiens] 46 3e-04
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 45 5e-04
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 45 6e-04
gi|114520609 neural precursor cell expressed, developmentally do... 44 0.001
gi|114520607 neural precursor cell expressed, developmentally do... 44 0.001
>gi|211971072 FERM and PDZ domain containing 4 [Homo sapiens]
Length = 1322
Score = 2631 bits (6819), Expect = 0.0
Identities = 1322/1322 (100%), Positives = 1322/1322 (100%)
Query: 1 MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIP 60
MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIP
Sbjct: 1 MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIP 60
Query: 61 FDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQI 120
FDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQI
Sbjct: 61 FDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQI 120
Query: 121 VMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRF 180
VMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRF
Sbjct: 121 VMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRF 180
Query: 181 SEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIK 240
SEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIK
Sbjct: 181 SEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIK 240
Query: 241 GIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRR 300
GIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRR
Sbjct: 241 GIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRR 300
Query: 301 DPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEW 360
DPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEW
Sbjct: 301 DPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEW 360
Query: 361 GLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYG 420
GLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYG
Sbjct: 361 GLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYG 420
Query: 421 GRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLV 480
GRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLV
Sbjct: 421 GRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLV 480
Query: 481 RVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETGPEN 540
RVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETGPEN
Sbjct: 481 RVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETGPEN 540
Query: 541 KGKHNLLGPDWNCIPQMTTFIGEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNA 600
KGKHNLLGPDWNCIPQMTTFIGEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNA
Sbjct: 541 KGKHNLLGPDWNCIPQMTTFIGEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNA 600
Query: 601 YSSDGLNQQLSQPGEAPCEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFAL 660
YSSDGLNQQLSQPGEAPCEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFAL
Sbjct: 601 YSSDGLNQQLSQPGEAPCEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFAL 660
Query: 661 DDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIG 720
DDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIG
Sbjct: 661 DDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIG 720
Query: 721 DVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDI 780
DVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDI
Sbjct: 721 DVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDI 780
Query: 781 IDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSL 840
IDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSL
Sbjct: 781 IDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSL 840
Query: 841 QNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYS 900
QNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYS
Sbjct: 841 QNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYS 900
Query: 901 PESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPA 960
PESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPA
Sbjct: 901 PESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPA 960
Query: 961 GGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVA 1020
GGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVA
Sbjct: 961 GGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVA 1020
Query: 1021 YSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFN 1080
YSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFN
Sbjct: 1021 YSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFN 1080
Query: 1081 LERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSD 1140
LERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSD
Sbjct: 1081 LERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSD 1140
Query: 1141 GSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMS 1200
GSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMS
Sbjct: 1141 GSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMS 1200
Query: 1201 SLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIP 1260
SLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIP
Sbjct: 1201 SLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIP 1260
Query: 1261 SEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKET 1320
SEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKET
Sbjct: 1261 SEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKET 1320
Query: 1321 TV 1322
TV
Sbjct: 1321 TV 1322
>gi|89060961 PREDICTED: FERM and PDZ domain containing 3 [Homo
sapiens]
Length = 1810
Score = 511 bits (1317), Expect = e-144
Identities = 265/477 (55%), Positives = 355/477 (74%), Gaps = 3/477 (0%)
Query: 48 RDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPG 107
++ F +H+ Q +D E Q+ R+V + RDP+ GFGFVAGSE+PVVVRSV PG
Sbjct: 26 QELFSSHVMQEESANDMECE--QLPAEILRQVTVHRDPIYGFGFVAGSERPVVVRSVRPG 83
Query: 108 GPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAK 167
GPSE KL+ GDQIV IN+E VS APRER+I+L+RS KE I+LTV+ + SPKSAFISAAK
Sbjct: 84 GPSENKLLAGDQIVAINEEDVSEAPRERLIELIRSAKEFIVLTVLHTHQSPKSAFISAAK 143
Query: 168 KARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIK 227
KA+L+SNPVKVRFSE+V + ++ +K +LL +PNVLKV+LENGQ KSF FD T++K
Sbjct: 144 KAKLRSNPVKVRFSEQVAVGETDAKMMKKEALLLIPNVLKVFLENGQIKSFTFDGRTTVK 203
Query: 228 DVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRI 287
DV+LTLQ++LS++ IEHF+L+LE K LLL +++ L V QR H M+CLFRI
Sbjct: 204 DVMLTLQDRLSLRFIEHFALVLEYAGPEQNHKFLLLQDKQPLAYVVQRTHYHGMKCLFRI 263
Query: 288 SFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQ 347
SF PKDP++LLRRDP AFEYLY+QS NDV++ERFG + K ++ L LAAL +YI T+
Sbjct: 264 SFFPKDPVELLRRDPAAFEYLYIQSRNDVIRERFGMDPKPEMLLGLAALHIYITVSATRP 323
Query: 348 TQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKV 407
+QKISLK +EKEWGLE FLP ++LQ +KEKN++K+LS +KA+Q G K SA+QAK+
Sbjct: 324 SQKISLKNVEKEWGLEPFLPPSLLQVIKEKNLRKSLSQQLKAHQTHPSCGTKGSAIQAKL 383
Query: 408 HYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHV 467
YL+ L++L + G +F T+ EK+S TLLVGPR+GISHVI+ KTNL +L++FS +
Sbjct: 384 QYLRILNELPTFTGVLFN-TVGLDEKQSATTLLVGPRHGISHVIDLKTNLTTVLSEFSKI 442
Query: 468 NRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFN 524
++I++F E + + RVE ++D KP+ LLME +A N ACL AGY RLL+DSR+ +F+
Sbjct: 443 SKIQLFRENQGVARVETSIMDAKPLVLLMEWPEATNFACLIAGYCRLLLDSRKMVFS 499
Score = 132 bits (332), Expect = 2e-30
Identities = 82/170 (48%), Positives = 109/170 (64%), Gaps = 6/170 (3%)
Query: 776 SSDDIIDLTSLPPPEGDDNEDDF-LLRSLNMAIAAPPPGFRD-SSDEEDSQSQAASFPED 833
S D+I+DL SLPPP ++ E++ SL AIAAPPPGFRD SSDE+D + +A E
Sbjct: 667 SRDNIVDLMSLPPPGSEEEEEEEDETTSLLPAIAAPPPGFRDNSSDEDDPKRRAVQSQEQ 726
Query: 834 KEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEE---QQTSDN 890
L DEIPV+LID+V T + LD+A+VSTL ALEAL+ SE+
Sbjct: 727 GRHLRGLLYDEIPVTLIDSVQTRTVRDHAQELDDALVSTLQALEALAASEDGPHPPPPQT 786
Query: 891 SGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATH 940
+G+ +L +PESS DSG+ETNSSE+T+ SE+ +A KQ +N + FLA H
Sbjct: 787 AGLIVLATITPESSLDSGHETNSSELTDMSEMMSAMKQHQN-TTYFLAQH 835
>gi|89059963 PREDICTED: FERM and PDZ domain containing 3 [Homo
sapiens]
Length = 1810
Score = 511 bits (1317), Expect = e-144
Identities = 265/477 (55%), Positives = 355/477 (74%), Gaps = 3/477 (0%)
Query: 48 RDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPG 107
++ F +H+ Q +D E Q+ R+V + RDP+ GFGFVAGSE+PVVVRSV PG
Sbjct: 26 QELFSSHVMQEESANDMECE--QLPAEILRQVTVHRDPIYGFGFVAGSERPVVVRSVRPG 83
Query: 108 GPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAK 167
GPSE KL+ GDQIV IN+E VS APRER+I+L+RS KE I+LTV+ + SPKSAFISAAK
Sbjct: 84 GPSENKLLAGDQIVAINEEDVSEAPRERLIELIRSAKEFIVLTVLHTHQSPKSAFISAAK 143
Query: 168 KARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIK 227
KA+L+SNPVKVRFSE+V + ++ +K +LL +PNVLKV+LENGQ KSF FD T++K
Sbjct: 144 KAKLRSNPVKVRFSEQVAVGETDAKMMKKEALLLIPNVLKVFLENGQIKSFTFDGRTTVK 203
Query: 228 DVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRI 287
DV+LTLQ++LS++ IEHF+L+LE K LLL +++ L V QR H M+CLFRI
Sbjct: 204 DVMLTLQDRLSLRFIEHFALVLEYAGPEQNHKFLLLQDKQPLAYVVQRTHYHGMKCLFRI 263
Query: 288 SFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQ 347
SF PKDP++LLRRDP AFEYLY+QS NDV++ERFG + K ++ L LAAL +YI T+
Sbjct: 264 SFFPKDPVELLRRDPAAFEYLYIQSRNDVIRERFGMDPKPEMLLGLAALHIYITVSATRP 323
Query: 348 TQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKV 407
+QKISLK +EKEWGLE FLP ++LQ +KEKN++K+LS +KA+Q G K SA+QAK+
Sbjct: 324 SQKISLKNVEKEWGLEPFLPPSLLQVIKEKNLRKSLSQQLKAHQTHPSCGTKGSAIQAKL 383
Query: 408 HYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHV 467
YL+ L++L + G +F T+ EK+S TLLVGPR+GISHVI+ KTNL +L++FS +
Sbjct: 384 QYLRILNELPTFTGVLFN-TVGLDEKQSATTLLVGPRHGISHVIDLKTNLTTVLSEFSKI 442
Query: 468 NRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFN 524
++I++F E + + RVE ++D KP+ LLME +A N ACL AGY RLL+DSR+ +F+
Sbjct: 443 SKIQLFRENQGVARVETSIMDAKPLVLLMEWPEATNFACLIAGYCRLLLDSRKMVFS 499
Score = 132 bits (332), Expect = 2e-30
Identities = 82/170 (48%), Positives = 109/170 (64%), Gaps = 6/170 (3%)
Query: 776 SSDDIIDLTSLPPPEGDDNEDDF-LLRSLNMAIAAPPPGFRD-SSDEEDSQSQAASFPED 833
S D+I+DL SLPPP ++ E++ SL AIAAPPPGFRD SSDE+D + +A E
Sbjct: 667 SRDNIVDLMSLPPPGSEEEEEEEDETTSLLPAIAAPPPGFRDNSSDEDDPKRRAVQSQEQ 726
Query: 834 KEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEE---QQTSDN 890
L DEIPV+LID+V T + LD+A+VSTL ALEAL+ SE+
Sbjct: 727 GRHLRGLLYDEIPVTLIDSVQTRTVRDHAQELDDALVSTLQALEALAASEDGPHPPPPQT 786
Query: 891 SGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATH 940
+G+ +L +PESS DSG+ETNSSE+T+ SE+ +A KQ +N + FLA H
Sbjct: 787 AGLIVLATITPESSLDSGHETNSSELTDMSEMMSAMKQHQN-TTYFLAQH 835
>gi|239582741 FERM and PDZ domain containing 1 [Homo sapiens]
Length = 1578
Score = 457 bits (1176), Expect = e-128
Identities = 238/482 (49%), Positives = 343/482 (71%), Gaps = 10/482 (2%)
Query: 62 DDPRLESCQIIPPAPRKVEMRRDPVL-GFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQI 120
D P Q + P V++ +D +L +GF P+ V +VT GG + GKL PGDQI
Sbjct: 41 DGPARNPTQTLIPVRHTVKIDKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQI 100
Query: 121 VMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPS-PKSAFISAAKKARLKSNPVKVR 179
+ +N+EP ER +D++R ++S+ +TV++ PKS+F++ K+ARLK+NPVKV
Sbjct: 101 LQMNNEPAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVH 160
Query: 180 FSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSI 239
F+EEV+I+G + NSLL MPNVLK+YLENGQTK+F+F+ +T++KD+ILT++EKLSI
Sbjct: 161 FAEEVLISGHS----QGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSI 216
Query: 240 KGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLR 299
+ IE+F+L LE++ + ++L LLHE+E + QV +R SH RCLFR+ FVPKDP+DLL+
Sbjct: 217 RSIEYFALALEEQY--SISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLK 274
Query: 300 RDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKE 359
DPVAFEYLY+QSC+DV+QERF E+K ALRLAAL + Q QKISLKYIEK+
Sbjct: 275 EDPVAFEYLYLQSCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKD 334
Query: 360 WGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKK--LSALQAKVHYLKFLSDLR 417
WG+E F+ +L++MK K+IKKA+S +K NQNL+ P +K +SA Q +++YL+ L +L+
Sbjct: 335 WGIENFISPTLLRNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELK 394
Query: 418 LYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEE 477
YGGR+F ATL+ ++ S + LLVG +YGIS VIN+K N+++ LA+F++++R+E+ E E
Sbjct: 395 TYGGRIFNATLMLQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESE 454
Query: 478 SLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETG 537
+ V++++ DVK +TLL+ES+ A +LACL AGYYRLLVD SIF K A + +
Sbjct: 455 KVSVVKVYLQDVKVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSA 514
Query: 538 PE 539
E
Sbjct: 515 EE 516
Score = 31.6 bits (70), Expect = 5.3
Identities = 14/15 (93%), Positives = 14/15 (93%)
Query: 995 MEMEPETMETKSVTD 1009
MEMEPETMETKSV D
Sbjct: 921 MEMEPETMETKSVID 935
>gi|239757877 PREDICTED: FERM and PDZ domain containing 3 [Homo
sapiens]
Length = 1662
Score = 351 bits (901), Expect = 2e-96
Identities = 203/448 (45%), Positives = 277/448 (61%), Gaps = 55/448 (12%)
Query: 77 RKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERV 136
R+V + RDP+ GFGFVAGSE+PVVVRSV PGGPSE KL+ GDQIV IN+E VS APRER+
Sbjct: 20 RQVTVHRDPIYGFGFVAGSERPVVVRSVRPGGPSENKLLAGDQIVAINEEDVSEAPRERL 79
Query: 137 IDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKD 196
I+L+RS KE I+LTV+ + SPKSAFISAAKKA+L+SNPVKVRFSE+V + ++ +K
Sbjct: 80 IELIRSAKEFIVLTVLHTHQSPKSAFISAAKKAKLRSNPVKVRFSEQVAVGETDAKMMKK 139
Query: 197 NSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGA 256
+LL +PNVLKV+LENGQ KSF FD T++KDV+LTLQ++LS++ IEHF+L+LE
Sbjct: 140 EALLLIPNVLKVFLENGQIKSFTFDGRTTVKDVMLTLQDRLSLRFIEHFALVLEYAGPEQ 199
Query: 257 GTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDV 316
K LLL +++ L V QR H M+CLFRISF PKDP++LLRRDP AFEYLY+Q
Sbjct: 200 NHKFLLLQDKQPLAYVVQRTHYHGMKCLFRISFFPKDPVELLRRDPAAFEYLYIQXXXXX 259
Query: 317 VQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKE 376
L+ ++ +L A Q + + T + L+Y+ L TF + VL +
Sbjct: 260 XXXIKEKNLRKSLSQQLKAHQTHPSCGTKGSAIQAKLQYLRILNELPTF--TGVLFNTVG 317
Query: 377 KNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSE 436
+ K++ + L LV P H + + DL+
Sbjct: 318 LDEKQSATTL------LVGPR----------HGISHVIDLK------------------- 342
Query: 437 VTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLM 496
TNL +L++FS +++I++F E + + RVE ++D KP+ LLM
Sbjct: 343 ------------------TNLTTVLSEFSKISKIQLFRENQGVARVETSIMDAKPLVLLM 384
Query: 497 ESSDAMNLACLTAGYYRLLVDSRRSIFN 524
E +A N ACL AGY RLL+DSR+ +F+
Sbjct: 385 EWPEATNFACLIAGYCRLLLDSRKMVFS 412
Score = 87.4 bits (215), Expect = 8e-17
Identities = 58/130 (44%), Positives = 80/130 (61%), Gaps = 9/130 (6%)
Query: 819 DEEDSQSQAASFPEDKEK-GSSLQN----DEIPVSLIDAVPTSAEGKCEKGLDNAVVSTL 873
D ++ Q++ P K GSS N DEIPV+LID+V T + LD+A+VSTL
Sbjct: 559 DSCKAKLQSSXGPSQSGKPGSSRDNILLYDEIPVTLIDSVQTRTVRDHAQELDDALVSTL 618
Query: 874 GALEALSVSEE---QQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSE 930
ALEAL+ SE+ +G+ +L +PESS DSG+ETNSSE+T+ SE+ +A KQ +
Sbjct: 619 QALEALAASEDGPHPPPPQTAGLIVLATITPESSLDSGHETNSSELTDMSEMMSAMKQHQ 678
Query: 931 NLSRMFLATH 940
N + FLA H
Sbjct: 679 N-TTYFLAQH 687
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 68.6 bits (166), Expect = 4e-11
Identities = 85/350 (24%), Positives = 156/350 (44%), Gaps = 39/350 (11%)
Query: 202 MPNVLKV--YLENGQTKS-----FRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQ-RT 253
M VLKV Y E+ + R +T ++ +I + + +K + + L R+
Sbjct: 55 MERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRS 114
Query: 254 EGAGTKLLLLHEQETLTQVTQR------PSSHKMRCLFRISFVPKDPIDLLRRDPVAFEY 307
E ++ LH ++ V ++ P K RI ++PK ++ D +
Sbjct: 115 E----EVHWLHVDMGVSSVREKYELAHPPEEWKYE--LRIRYLPKGFLNQFTEDKPTLNF 168
Query: 308 LYVQSCNDVVQERFGPELKYDIALRLAALQM---YIATVTTKQTQKISLKYIEKEWGLET 364
Y Q +D + E ++ +IAL+L L++ Y +K + + +EK+ GL+
Sbjct: 169 FYQQVKSDYMLE-IADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKR 227
Query: 365 FLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVF 424
F P ++L S+K K ++K + + N L+ ++ + + + LS + + F
Sbjct: 228 FFPKSLLDSVKAKTLRKLIQQTFRQFAN-------LNREESILKFFEILSPVYRFDKECF 280
Query: 425 KATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVEL 484
K L + S V L +GP GIS++ + N LADF+ V I+ +S E R +
Sbjct: 281 KCALGSSWIIS-VELAIGPEEGISYLTDKGCN-PTHLADFTQVQTIQ-YSNSEDKDRKGM 337
Query: 485 HVLDV----KPITLLMES-SDAMNLACLTAGYYRLLVDSRRSIFNMANKK 529
L + +P+T+ S + A N+A L GY RL+ + +S K+
Sbjct: 338 LQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKE 387
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 68.6 bits (166), Expect = 4e-11
Identities = 85/350 (24%), Positives = 156/350 (44%), Gaps = 39/350 (11%)
Query: 202 MPNVLKV--YLENGQTKS-----FRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQ-RT 253
M VLKV Y E+ + R +T ++ +I + + +K + + L R+
Sbjct: 33 MERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRS 92
Query: 254 EGAGTKLLLLHEQETLTQVTQR------PSSHKMRCLFRISFVPKDPIDLLRRDPVAFEY 307
E ++ LH ++ V ++ P K RI ++PK ++ D +
Sbjct: 93 E----EVHWLHVDMGVSSVREKYELAHPPEEWKYE--LRIRYLPKGFLNQFTEDKPTLNF 146
Query: 308 LYVQSCNDVVQERFGPELKYDIALRLAALQM---YIATVTTKQTQKISLKYIEKEWGLET 364
Y Q +D + E ++ +IAL+L L++ Y +K + + +EK+ GL+
Sbjct: 147 FYQQVKSDYMLE-IADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKR 205
Query: 365 FLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVF 424
F P ++L S+K K ++K + + N L+ ++ + + + LS + + F
Sbjct: 206 FFPKSLLDSVKAKTLRKLIQQTFRQFAN-------LNREESILKFFEILSPVYRFDKECF 258
Query: 425 KATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVEL 484
K L + S V L +GP GIS++ + N LADF+ V I+ +S E R +
Sbjct: 259 KCALGSSWIIS-VELAIGPEEGISYLTDKGCN-PTHLADFTQVQTIQ-YSNSEDKDRKGM 315
Query: 485 HVLDV----KPITLLMES-SDAMNLACLTAGYYRLLVDSRRSIFNMANKK 529
L + +P+T+ S + A N+A L GY RL+ + +S K+
Sbjct: 316 LQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKE 365
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 62.4 bits (150), Expect = 3e-09
Identities = 64/273 (23%), Positives = 128/273 (46%), Gaps = 28/273 (10%)
Query: 263 LHEQETLTQVTQRPSSHKMRCLFR----ISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQ 318
LH Q T+ +V + + +R I ++P+D ++ L+ D Y Y Q ND +Q
Sbjct: 105 LHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQ 164
Query: 319 ERFGPELKYDIALRLAALQM---YIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMK 375
R+ ++ +AL+L L++ + +K + + +EKE GL+ F P + +++K
Sbjct: 165 -RYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLK 223
Query: 376 EKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGG---RVFKATLVQAE 432
K +K + ++ ++L+ + +KF + L + ++ L+Q
Sbjct: 224 PKQFRKMIQQTF----------QQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGW 273
Query: 433 KRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPI 492
+ V L++GP+ GI + ++ LA+F + I EE ++L + + P
Sbjct: 274 NIT-VDLVIGPK-GIRQ-LTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGI-EGAPQ 329
Query: 493 TLLMESS---DAMNLACLTAGYYRLLVDSRRSI 522
L +++S +A N+A L GY RL + + S+
Sbjct: 330 ALSIKTSSLAEAENMADLIDGYCRLQGEHQGSL 362
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 62.4 bits (150), Expect = 3e-09
Identities = 64/273 (23%), Positives = 128/273 (46%), Gaps = 28/273 (10%)
Query: 263 LHEQETLTQVTQRPSSHKMRCLFR----ISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQ 318
LH Q T+ +V + + +R I ++P+D ++ L+ D Y Y Q ND +Q
Sbjct: 105 LHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQ 164
Query: 319 ERFGPELKYDIALRLAALQM---YIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMK 375
R+ ++ +AL+L L++ + +K + + +EKE GL+ F P + +++K
Sbjct: 165 -RYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLK 223
Query: 376 EKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGG---RVFKATLVQAE 432
K +K + ++ ++L+ + +KF + L + ++ L+Q
Sbjct: 224 PKQFRKMIQQTF----------QQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGW 273
Query: 433 KRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPI 492
+ V L++GP+ GI + ++ LA+F + I EE ++L + + P
Sbjct: 274 NIT-VDLVIGPK-GIRQ-LTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGI-EGAPQ 329
Query: 493 TLLMESS---DAMNLACLTAGYYRLLVDSRRSI 522
L +++S +A N+A L GY RL + + S+
Sbjct: 330 ALSIKTSSLAEAENMADLIDGYCRLQGEHQGSL 362
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 62.4 bits (150), Expect = 3e-09
Identities = 64/273 (23%), Positives = 128/273 (46%), Gaps = 28/273 (10%)
Query: 263 LHEQETLTQVTQRPSSHKMRCLFR----ISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQ 318
LH Q T+ +V + + +R I ++P+D ++ L+ D Y Y Q ND +Q
Sbjct: 105 LHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQ 164
Query: 319 ERFGPELKYDIALRLAALQM---YIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMK 375
R+ ++ +AL+L L++ + +K + + +EKE GL+ F P + +++K
Sbjct: 165 -RYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLK 223
Query: 376 EKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGG---RVFKATLVQAE 432
K +K + ++ ++L+ + +KF + L + ++ L+Q
Sbjct: 224 PKQFRKMIQQTF----------QQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGW 273
Query: 433 KRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPI 492
+ V L++GP+ GI + ++ LA+F + I EE ++L + + P
Sbjct: 274 NIT-VDLVIGPK-GIRQ-LTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGI-EGAPQ 329
Query: 493 TLLMESS---DAMNLACLTAGYYRLLVDSRRSI 522
L +++S +A N+A L GY RL + + S+
Sbjct: 330 ALSIKTSSLAEAENMADLIDGYCRLQGEHQGSL 362
>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 62.4 bits (150), Expect = 3e-09
Identities = 64/273 (23%), Positives = 128/273 (46%), Gaps = 28/273 (10%)
Query: 263 LHEQETLTQVTQRPSSHKMRCLFR----ISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQ 318
LH Q T+ +V + + +R I ++P+D ++ L+ D Y Y Q ND +Q
Sbjct: 105 LHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQ 164
Query: 319 ERFGPELKYDIALRLAALQM---YIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMK 375
R+ ++ +AL+L L++ + +K + + +EKE GL+ F P + +++K
Sbjct: 165 -RYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLK 223
Query: 376 EKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGG---RVFKATLVQAE 432
K +K + ++ ++L+ + +KF + L + ++ L+Q
Sbjct: 224 PKQFRKMIQQTF----------QQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGW 273
Query: 433 KRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPI 492
+ V L++GP+ GI + ++ LA+F + I EE ++L + + P
Sbjct: 274 NIT-VDLVIGPK-GIRQ-LTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGI-EGAPQ 329
Query: 493 TLLMESS---DAMNLACLTAGYYRLLVDSRRSI 522
L +++S +A N+A L GY RL + + S+
Sbjct: 330 ALSIKTSSLAEAENMADLIDGYCRLQGEHQGSL 362
>gi|223029410 talin 1 [Homo sapiens]
Length = 2541
Score = 56.6 bits (135), Expect = 2e-07
Identities = 81/343 (23%), Positives = 143/343 (41%), Gaps = 52/343 (15%)
Query: 206 LKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFS----LMLEQRTEGAGT--- 258
LK+ + +G K+ D S ++ D+++T+ ++ I + +S LM E++ E GT
Sbjct: 88 LKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKEEITGTLRK 147
Query: 259 -KLLL------------LHEQETL-------TQVTQRPSSHKMRCLFRISFVPKDPIDLL 298
K LL LH + L T Q H+ L R F +D
Sbjct: 148 DKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVD-- 205
Query: 299 RRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEK 358
RDPV LYVQ+ +D++ + +D A A Q I QK +++
Sbjct: 206 SRDPVQLNLLYVQARDDILNG--SHPVSFDKACEFAGFQCQI-QFGPHNEQKHKAGFLD- 261
Query: 359 EWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRL 418
L+ FLP + +K+K +K + +A++N ++S ++AKV Y+K L+
Sbjct: 262 ---LKDFLPK---EYVKQKGERK----IFQAHKNC----GQMSEIEAKVRYVKLARSLKT 307
Query: 419 YGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEES 478
YG F K V L+G ++ KT V + +++ R S
Sbjct: 308 YGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKR-----WAAS 362
Query: 479 LVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRS 521
L D + +++++ +A L AGY +++ ++S
Sbjct: 363 PKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKS 405
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 53.9 bits (128), Expect = 1e-06
Identities = 55/216 (25%), Positives = 89/216 (41%), Gaps = 53/216 (24%)
Query: 15 HRTKSSGWPPPSGTWGLSQVP--------PYGWEMTANRDGRDYFINHMTQAIPFDDP-- 64
H TK++ W P ++ P PYGWE + Y+++H+ Q F++P
Sbjct: 314 HNTKTTTWLDPR-LCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVE 372
Query: 65 ------RLESCQI--IPPAPRKVEMRRDP---------------VLGFGF-VAGSEKP-- 98
+L +I P K RDP +GFGF + G ++P
Sbjct: 373 EAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDE 432
Query: 99 -VVVRSVTPGGPS--EGKLIPGDQIVMINDEPVSAAPRERVIDLVR--SCKESILLTVIQ 153
+ V++V GP+ +GK+ PGD IV IN V V+ + + + + LT+ +
Sbjct: 433 FLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCR 492
Query: 154 PYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQ 189
YP P + +PV + +INGQ
Sbjct: 493 GYPLPDDS-----------EDPVVDIVAATPVINGQ 517
Score = 45.4 bits (106), Expect = 4e-04
Identities = 35/129 (27%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 64 PRLESCQI----IPPAPRKVEMRRDPVLGFGFVAGSEK--------PVVVRSVTPGGPSE 111
PRL ++ P P V ++R GFGFV + K P + V G P++
Sbjct: 833 PRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPAD 892
Query: 112 --GKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVI--QPYPSPKSAFISAAK 167
GKL GD I +N + + + ++ L++ ++ LTVI + + P S SA +
Sbjct: 893 RCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQ 952
Query: 168 KARLKSNPV 176
L+ P+
Sbjct: 953 SPALQHRPM 961
Score = 38.5 bits (88), Expect = 0.043
Identities = 26/77 (33%), Positives = 39/77 (50%), Gaps = 7/77 (9%)
Query: 79 VEMRRDPVLGFGFVAGSEKP----VVVRSVTPGGPS--EGKLIPGDQIVMINDEPVSAAP 132
VE+ R P GFGF K + + + GP+ +G++ GDQIV IN EP
Sbjct: 1022 VELERGP-RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT 1080
Query: 133 RERVIDLVRSCKESILL 149
R I+L+++ +LL
Sbjct: 1081 HTRAIELIQAGGNKVLL 1097
Score = 35.4 bits (80), Expect = 0.37
Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 17/109 (15%)
Query: 73 PPAPRKVEM-RRDPVLGFGF-VAGSEKP---VVVRSVTPGGPSE--GKLIPGDQIVMIND 125
PP + +++ R GFGF V G + P + + ++ P G +E G+L D+++ I+
Sbjct: 719 PPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDG 778
Query: 126 EPVSAAPRERVIDLVRSCKES--ILLTV--------IQPYPSPKSAFIS 164
PV ++V+DL+ + + +LLTV QP AFIS
Sbjct: 779 IPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFIS 827
Score = 32.0 bits (71), Expect = 4.0
Identities = 23/66 (34%), Positives = 30/66 (45%), Gaps = 12/66 (18%)
Query: 36 PYGWEMTANRDGRDYFINHMTQAIPFDDPRL-------ESCQ--IIPPAPRKVEMRRDPV 86
P WEM G YFI+H T+ + DPRL E C+ +P K+E DP
Sbjct: 296 PKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIE---DPQ 352
Query: 87 LGFGFV 92
G +V
Sbjct: 353 YGTYYV 358
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 53.9 bits (128), Expect = 1e-06
Identities = 55/216 (25%), Positives = 89/216 (41%), Gaps = 53/216 (24%)
Query: 15 HRTKSSGWPPPSGTWGLSQVP--------PYGWEMTANRDGRDYFINHMTQAIPFDDP-- 64
H TK++ W P ++ P PYGWE + Y+++H+ Q F++P
Sbjct: 314 HNTKTTTWLDPR-LCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVE 372
Query: 65 ------RLESCQI--IPPAPRKVEMRRDP---------------VLGFGF-VAGSEKP-- 98
+L +I P K RDP +GFGF + G ++P
Sbjct: 373 EAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDE 432
Query: 99 -VVVRSVTPGGPS--EGKLIPGDQIVMINDEPVSAAPRERVIDLVR--SCKESILLTVIQ 153
+ V++V GP+ +GK+ PGD IV IN V V+ + + + + LT+ +
Sbjct: 433 FLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCR 492
Query: 154 PYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQ 189
YP P + +PV + +INGQ
Sbjct: 493 GYPLPDDS-----------EDPVVDIVAATPVINGQ 517
Score = 45.4 bits (106), Expect = 4e-04
Identities = 35/129 (27%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 64 PRLESCQI----IPPAPRKVEMRRDPVLGFGFVAGSEK--------PVVVRSVTPGGPSE 111
PRL ++ P P V ++R GFGFV + K P + V G P++
Sbjct: 833 PRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPAD 892
Query: 112 --GKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVI--QPYPSPKSAFISAAK 167
GKL GD I +N + + + ++ L++ ++ LTVI + + P S SA +
Sbjct: 893 RCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQ 952
Query: 168 KARLKSNPV 176
L+ P+
Sbjct: 953 SPALQHRPM 961
Score = 38.5 bits (88), Expect = 0.043
Identities = 26/77 (33%), Positives = 39/77 (50%), Gaps = 7/77 (9%)
Query: 79 VEMRRDPVLGFGFVAGSEKP----VVVRSVTPGGPS--EGKLIPGDQIVMINDEPVSAAP 132
VE+ R P GFGF K + + + GP+ +G++ GDQIV IN EP
Sbjct: 1022 VELERGP-RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT 1080
Query: 133 RERVIDLVRSCKESILL 149
R I+L+++ +LL
Sbjct: 1081 HTRAIELIQAGGNKVLL 1097
Score = 35.4 bits (80), Expect = 0.37
Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 17/109 (15%)
Query: 73 PPAPRKVEM-RRDPVLGFGF-VAGSEKP---VVVRSVTPGGPSE--GKLIPGDQIVMIND 125
PP + +++ R GFGF V G + P + + ++ P G +E G+L D+++ I+
Sbjct: 719 PPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDG 778
Query: 126 EPVSAAPRERVIDLVRSCKES--ILLTV--------IQPYPSPKSAFIS 164
PV ++V+DL+ + + +LLTV QP AFIS
Sbjct: 779 IPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFIS 827
Score = 32.0 bits (71), Expect = 4.0
Identities = 23/66 (34%), Positives = 30/66 (45%), Gaps = 12/66 (18%)
Query: 36 PYGWEMTANRDGRDYFINHMTQAIPFDDPRL-------ESCQ--IIPPAPRKVEMRRDPV 86
P WEM G YFI+H T+ + DPRL E C+ +P K+E DP
Sbjct: 296 PKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIE---DPQ 352
Query: 87 LGFGFV 92
G +V
Sbjct: 353 YGTYYV 358
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 53.5 bits (127), Expect = 1e-06
Identities = 29/79 (36%), Positives = 45/79 (56%), Gaps = 5/79 (6%)
Query: 81 MRRDPVLGFGFV--AGSEKP---VVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRER 135
+ +DP GFG G ++P +VV V PGGP+EG+L GD IVM+N + A
Sbjct: 33 LSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENATSAF 92
Query: 136 VIDLVRSCKESILLTVIQP 154
I ++++C + +TV +P
Sbjct: 93 AIQILKTCTKMANITVKRP 111
Score = 37.7 bits (86), Expect = 0.074
Identities = 20/68 (29%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 74 PAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIP-GDQIVMINDEPVSAAP 132
P R V + +G G++ + V V G P++G+ I GDQI+ +ND P
Sbjct: 412 PDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLT 471
Query: 133 RERVIDLV 140
RE + +
Sbjct: 472 REEAVQFL 479
>gi|161016767 mucin 21 [Homo sapiens]
Length = 566
Score = 53.5 bits (127), Expect = 1e-06
Identities = 77/391 (19%), Positives = 138/391 (35%), Gaps = 30/391 (7%)
Query: 867 NAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQ 926
N+ ST + + + + E T + + S +SS + TNS T SSE +TA
Sbjct: 107 NSESSTTSSGASTATNSESSTPSSGASTATNSDSSTTSSGASTATNSDSSTTSSEASTAT 166
Query: 927 KQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPPKVVPS 986
+ T G ++ +S+ S+ + A AT+ + S
Sbjct: 167 NSESS------TTSSGASTATNSESSTVSSRASTATNSESSTTSSGASTATNSESRTT-S 219
Query: 987 KQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTG 1046
+ + E + + T+ S S A + T+ S + G G A + ++T
Sbjct: 220 NGAGTATNSESSTTSSGASTATNSESST-PSSGAGTATNSESSTTSSGAGTATNSESST- 277
Query: 1047 KKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSG 1106
G T E ++ G ++ +S+ +T + TA DS T G + +
Sbjct: 278 -VSSGISTVTNSESSTPSSGANTATNSESSTTSSGANTATNSDSS----TTSSGASTATN 332
Query: 1107 LEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLDNP 1166
E++T T AS E+ GA S S G T+ ++ +
Sbjct: 333 SESST--TSSGASTATNSESSTTSSGASTATNSGSSTTSSGTSTATNSESSTVSSGASTA 390
Query: 1167 EDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGS 1226
++SST + E SS S G + +S+ S+ +G T +
Sbjct: 391 TTSESSTTSSGASTATNSE--------------SSTVSSGASTATNSESSTTSSGANTAT 436
Query: 1227 SGSACATPVESPLCPSLGKHLIPDASGKGVN 1257
+ + T S G H ++ V+
Sbjct: 437 NSGSSVTSAGSGTAALTGMHTTSHSASTAVS 467
Score = 52.8 bits (125), Expect = 2e-06
Identities = 83/392 (21%), Positives = 151/392 (38%), Gaps = 27/392 (6%)
Query: 860 KCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNS--SEMT 917
K +KG + L LEA + S E TS N+G +++ + + +++ + T+S S T
Sbjct: 2 KMQKGNVLLMFGLLLHLEAATNSNETSTSANTGSSVISSGASTATNSGSSVTSSGVSTAT 61
Query: 918 ESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPAT 977
S T+ S + F T G + +S S+ + A AT
Sbjct: 62 ISGSSVTSNGVSIVTNSEFHTTSSGISTATNSEFSTVSSGISIATNSESSTTSSGASTAT 121
Query: 978 DLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGK 1037
+ PS + + + + + T+ S S A + T+ S + G
Sbjct: 122 N-SESSTPSSGASTATNSDSSTTSSGASTATNSDSST-TSSEASTATNSESSTTSSGAST 179
Query: 1038 APPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVAT 1097
A + ++T + TA E ++ G ++ +S+ +T N TA +S T
Sbjct: 180 ATNSESSTVSSR--ASTATNSESSTTSSGASTATNSESRTTSNGAGTATNSESS----TT 233
Query: 1098 EGGMAEKSGLEAATGKTFPRASGLGA---REAEGKEEGAPDGETSDGSGLGQGDRFLTDV 1154
G + + E++T +SG G E+ GA S+ S + G +T+
Sbjct: 234 SSGASTATNSESST-----PSSGAGTATNSESSTTSSGAGTATNSESSTVSSGISTVTNS 288
Query: 1155 TCASSAKDLDNPEDADSSTCDH-PSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSS 1213
++ + + +++SST + +D S SS S G + +S
Sbjct: 289 ESSTPSSGANTATNSESSTTSSGANTATNSDSSTTSSGASTATNSESSTTSSGASTATNS 348
Query: 1214 QGSSVDAGCGTG--------SSGSACATPVES 1237
+ S+ +G T SSG++ AT ES
Sbjct: 349 ESSTTSSGASTATNSGSSTTSSGTSTATNSES 380
>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
Length = 1441
Score = 51.6 bits (122), Expect = 5e-06
Identities = 80/361 (22%), Positives = 141/361 (39%), Gaps = 60/361 (16%)
Query: 736 LHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNE 795
L+D+ N D+ E EDE + G ++ + SD+ D + PP DD++
Sbjct: 1091 LNDLDSDSNLDEEESEDEFKISD----GSQDEFVV------SDENPDESEEDPPSNDDSD 1140
Query: 796 DDFLLRSLNMAIAAP----------PPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEI 845
DF R L + P P + S D+E+ +S+ E+ S +D+
Sbjct: 1141 TDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESE-----ENSRDSESDFSDDF 1195
Query: 846 PVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSS 905
++ + ++ ++ + S S+ Q S G I R + SS
Sbjct: 1196 SDDFVETRRRRSRRNQKRQIN---------YKEDSESDGSQKSLRRGKEIRRVHKRRLSS 1246
Query: 906 DSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPP 965
E+ S+ +E ELA K+S + + +T E + A+E+ E K L
Sbjct: 1247 SESEESYLSKNSEDDELAKESKRS--VRKRGRSTDE--YSEADEEEEEEEGKPSRKRLHR 1302
Query: 966 ---------KSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHM 1016
++H A +PA D P+V+PS+Q +P +E+ D+ + +
Sbjct: 1303 IETDEEESCDNAHGDANQPARDSQPRVLPSEQ-----ESTKKPYRIESDEEEDFENVGKV 1357
Query: 1017 GS-VAYSCTSKRKSKLADGEGKAPPNG--NTTGKKQQGTKTAEMEEEASGKFGTVSSRDS 1073
GS + YS L G++P N GK + ++T + AS + +
Sbjct: 1358 GSPLDYSLVD-----LPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGG 1412
Query: 1074 Q 1074
Q
Sbjct: 1413 Q 1413
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 50.1 bits (118), Expect = 1e-05
Identities = 74/428 (17%), Positives = 161/428 (37%), Gaps = 16/428 (3%)
Query: 816 DSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGA 875
DSSD DS S ++ D + S +D D+ +S D++ S
Sbjct: 562 DSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 621
Query: 876 LEALSVSEEQQT------SDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQS 929
++ S E + SD+S + SSDS N +NSS+ ++SS+ + + S
Sbjct: 622 SKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSS 681
Query: 930 ENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPPKVVPSKQL 989
++ + + +E +S + + S+ + +++ S
Sbjct: 682 DSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSS 741
Query: 990 LHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTGKKQ 1049
SD + + ++ +D + + S S S +D + + ++
Sbjct: 742 DSSDSSD-SSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS 800
Query: 1050 QGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSGLEA 1109
+ + ++S + SS S ++ + ++ DS +++G ++ S
Sbjct: 801 SDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSD 860
Query: 1110 ATGKTFPRASGLGAREAEGKE-----EGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLD 1164
++ + S + ++ + E + ++SD S D +D + +S + D
Sbjct: 861 SSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDS--SDSSNSSDSSDSS 918
Query: 1165 NPEDA--DSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGC 1222
N D+ S++ D+ + ++ S + SS S+ S SS +S D+
Sbjct: 919 NSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSD 978
Query: 1223 GTGSSGSA 1230
+ SS S+
Sbjct: 979 SSNSSDSS 986
Score = 45.4 bits (106), Expect = 4e-04
Identities = 82/498 (16%), Positives = 183/498 (36%), Gaps = 23/498 (4%)
Query: 742 AENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLR 801
+ ++ D+ + E S D + + + + S SSD D ++ N D
Sbjct: 689 SSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDS--DSSNSSDSSDSSNSSDSS-D 745
Query: 802 SLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKC 861
S + + ++ DSS+ DS + S SS ND S D+ +S
Sbjct: 746 SSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSS--DSSDSSNSSDS 803
Query: 862 EKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSE 921
D++ S ++ + S+ +SD+S + S S S G++++SS ++SS
Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSN 863
Query: 922 LATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPP 981
+ + S++ + ++ + E + S + SS + + ++D
Sbjct: 864 SSDSSDSSDSSN----SSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSN 919
Query: 982 KVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPN 1041
S+ SD+ + + S +D + + S S S +D +
Sbjct: 920 SSDSSESSNSSDNSNSSDSSNSSDS-SDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSD 978
Query: 1042 GNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGM 1101
+ + + +++ + + + SS S + N ++ DS +++
Sbjct: 979 SSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSD 1038
Query: 1102 AEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFL--------TD 1153
+ S + + + ++ + ++ + + ++SD S + +D
Sbjct: 1039 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSD 1098
Query: 1154 VTCASSAKDL-DNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQS 1212
+ +S + D D+ + +DSS + S ++ +S D + S S S
Sbjct: 1099 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS----SDSSDSSNSSDSSDSSESSDSS 1154
Query: 1213 SQGSSVDAGCGTGSSGSA 1230
S D+ + SS S+
Sbjct: 1155 DSSDSSDSSDSSDSSDSS 1172
Score = 43.9 bits (102), Expect = 0.001
Identities = 70/459 (15%), Positives = 171/459 (37%), Gaps = 23/459 (5%)
Query: 742 AENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLR 801
+ N+ D+ D + S + + + + + S +S D D S +G D++
Sbjct: 803 SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD--SSDSSDGSDSDSSNRSD 860
Query: 802 SLNMAIAAPPPGFRDSSDEEDSQ--SQAASFPEDKEKGSSLQNDEIPVS----LIDAVPT 855
S N + ++ +SSD DS +++++ + + +S +D S D+ +
Sbjct: 861 SSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNS 920
Query: 856 SAEGKCEKGLDNAVVS-------TLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSG 908
S + DN+ S + + ++ + S+ +SD+S + + SSDS
Sbjct: 921 SDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSS 980
Query: 909 NETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSS 968
N ++SS+ ++SS+ + + S + + ++ +S + SS
Sbjct: 981 NSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSS 1040
Query: 969 HALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRK 1028
+ + ++D S +S ++ ++ +D + S S
Sbjct: 1041 DSSDSSDSSD-------SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNS 1093
Query: 1029 SKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLS-TFNLERTAFR 1087
S +D + + ++ + + ++S + S DS + S + + ++
Sbjct: 1094 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDS 1153
Query: 1088 KDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQG 1147
DS +++ + S + + + + + ++ + + ++SD S
Sbjct: 1154 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1213
Query: 1148 DRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADES 1186
+ S+ D+ E +DSS S + +S
Sbjct: 1214 SDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDS 1252
Score = 40.4 bits (93), Expect = 0.011
Identities = 67/440 (15%), Positives = 165/440 (37%), Gaps = 23/440 (5%)
Query: 813 GFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVST 872
G DSSD + S S +S D S ++ S S++ D+ +
Sbjct: 545 GKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDS------DSSDSDSSDSSDSDSSDS 598
Query: 873 LGALEALSVSEEQQTSDNSGVAILRAYSPESSSDS--------GNETNSSEMTESSELAT 924
+ ++ S+ +SD+S + ++ S +S SDS +++NSS+ +++S+ +
Sbjct: 599 SNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSD 658
Query: 925 AQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHA--LAARPATDLPPK 982
+ S + + ++ +S + +SS + + ++D
Sbjct: 659 SSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDS 718
Query: 983 VVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNG 1042
+ S + ++ + +D + + S S S +D + +
Sbjct: 719 SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSD 778
Query: 1043 NTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMA 1102
++ + + ++S + +S DS S + ++ DS +++ +
Sbjct: 779 SSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNS 838
Query: 1103 EKS-----GLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCA 1157
S + + + R+ + ++ + + ++SD S + +D + +
Sbjct: 839 SDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSN-SSDSSDS 897
Query: 1158 SSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSS 1217
S++ D D+ + ++SS S ++ ES + D + S+ S S+ S
Sbjct: 898 SNSSDSDSSDSSNSSDSSDSSNSSDSSES-SNSSDNSNSSDSSNSSDSSDSSDSSNSSDS 956
Query: 1218 VDAGCGTGSSGSACATPVES 1237
++ + SS S+ + +S
Sbjct: 957 SNSSDSSNSSDSSDSNSSDS 976
Score = 37.7 bits (86), Expect = 0.074
Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 14/193 (7%)
Query: 742 AENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLR 801
+ N+ D+ D + S D + + + + S +S D D + N D
Sbjct: 1090 SSNSSDSSDSSDSSDSSDS--SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD---- 1143
Query: 802 SLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKC 861
S + + ++ DSSD DS + S SS +D S D+ +S
Sbjct: 1144 SSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS--DSSDSSDSSDS 1201
Query: 862 EKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPES-SSDSGNETNSSEMTESS 920
D++ S ++ S+ +SD+S + S S SSDS + +NSS+ ++SS
Sbjct: 1202 SDSSDSSDSS-----DSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSS 1256
Query: 921 ELATAQKQSENLS 933
+ + + S + S
Sbjct: 1257 DSSDSTSDSNDES 1269
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/81 (34%), Positives = 47/81 (58%), Gaps = 5/81 (6%)
Query: 76 PRKVEM-RRDPVLGFGFVAGSEK--PVVVRSVTPGGPSE--GKLIPGDQIVMINDEPVSA 130
PR VE+ + D LGF + G E+ P+ + + PGG +E G L GDQ++ +N V
Sbjct: 106 PRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
Query: 131 APRERVIDLVRSCKESILLTV 151
E+ ++L+++ K+S+ L V
Sbjct: 166 EHHEKAVELLKAAKDSVKLVV 186
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 48.9 bits (115), Expect = 3e-05
Identities = 26/67 (38%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 87 LGFGFVAGSEKPVVVRSVTPGG--PSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCK 144
LGFG V G VVVR++ PGG +G+L GD I+ I V E+V ++R+C
Sbjct: 258 LGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCG 317
Query: 145 ESILLTV 151
S+ + V
Sbjct: 318 NSVRMLV 324
Score = 35.0 bits (79), Expect = 0.48
Identities = 24/90 (26%), Positives = 42/90 (46%), Gaps = 6/90 (6%)
Query: 68 SCQIIPPAPRKVEMRRDPV-LGFGFVAGSEKP---VVVRSVTPGGPS--EGKLIPGDQIV 121
+C I+P +E+ + LG V G + P +V+ V G + +G+L GDQI+
Sbjct: 1427 TCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQIL 1486
Query: 122 MINDEPVSAAPRERVIDLVRSCKESILLTV 151
+N + + E I +R + + L V
Sbjct: 1487 EVNGVDLRNSSHEEAITALRQTPQKVRLVV 1516
Score = 32.3 bits (72), Expect = 3.1
Identities = 16/55 (29%), Positives = 31/55 (56%), Gaps = 2/55 (3%)
Query: 99 VVVRSVTPGGPSE--GKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTV 151
V + + GG ++ G+LI GDQI+ +N E + A +E V +++ + + L +
Sbjct: 1557 VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI 1611
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 48.1 bits (113), Expect = 5e-05
Identities = 49/191 (25%), Positives = 78/191 (40%), Gaps = 47/191 (24%)
Query: 15 HRTKSSGWPPPSGTWGLSQVP-------PYGWEMTANRDGRDYFINHMTQAIPFDDPRLE 67
H TK++ W P PYGWE + Y+++H+ + F++P LE
Sbjct: 323 HNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLE 382
Query: 68 SCQII-----------------PPAPRKVEMRRDPV---------------LGFGF-VAG 94
+ + + P K RD +GFGF + G
Sbjct: 383 AKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIG 442
Query: 95 SEKP---VVVRSVTPGGPS--EGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCK--ESI 147
++P + V+SV P GP+ +GK+ GD IV IN+ V V+ L +S +S+
Sbjct: 443 GDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSV 502
Query: 148 LLTVIQPYPSP 158
L + + YP P
Sbjct: 503 NLVLCRGYPLP 513
Score = 35.8 bits (81), Expect = 0.28
Identities = 20/63 (31%), Positives = 36/63 (57%), Gaps = 4/63 (6%)
Query: 82 RRDPVLGFGFVAGSE--KPVVVRSVTPGGPSE--GKLIPGDQIVMINDEPVSAAPRERVI 137
R + GF + G E +P+++ +V G ++ G+L PGD++V ++ PV+ VI
Sbjct: 783 RMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVI 842
Query: 138 DLV 140
DL+
Sbjct: 843 DLM 845
Score = 33.1 bits (74), Expect = 1.8
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 12/66 (18%)
Query: 36 PYGWEMTANRDGRDYFINHMTQAIPFDDPRL-------ESCQ--IIPPAPRKVEMRRDPV 86
P WEM G YFI+H T+ + DPRL E C+ +P K++ DP+
Sbjct: 305 PDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKID---DPI 361
Query: 87 LGFGFV 92
G +V
Sbjct: 362 YGTYYV 367
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 47.8 bits (112), Expect = 7e-05
Identities = 22/67 (32%), Positives = 38/67 (56%), Gaps = 2/67 (2%)
Query: 87 LGFGFVAGSEKPVVVRSVTPGGPSE--GKLIPGDQIVMINDEPVSAAPRERVIDLVRSCK 144
LGFG + G V+V+++ PGG ++ G+L GD I+ I D ++ E+V ++R C
Sbjct: 267 LGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCG 326
Query: 145 ESILLTV 151
+ L +
Sbjct: 327 NRVKLMI 333
Score = 45.4 bits (106), Expect = 4e-04
Identities = 22/77 (28%), Positives = 48/77 (62%), Gaps = 4/77 (5%)
Query: 99 VVVRSVTPGGPSE--GKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKE-SILLTVIQPY 155
+++RS+ PGG +E G+L+PGD+++ +ND + + E ++ ++ ++ + V +P
Sbjct: 728 IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPL 787
Query: 156 P-SPKSAFISAAKKARL 171
P SP+ ++SA + + L
Sbjct: 788 PLSPEEGYVSAKEDSFL 804
Score = 42.4 bits (98), Expect = 0.003
Identities = 24/78 (30%), Positives = 45/78 (57%), Gaps = 2/78 (2%)
Query: 99 VVVRSVTPGG--PSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYP 156
V+++S+T G ++G+L GDQI+ ++DE V P E+ I L+++ K ++ LT+ P
Sbjct: 1506 VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENP 1565
Query: 157 SPKSAFISAAKKARLKSN 174
++ +A + K N
Sbjct: 1566 DSQAVPSAAGAASGEKKN 1583
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 8/88 (9%)
Query: 73 PPAPRKVEMRRDPV-LGFGFVAG-----SEKPVVVRSVTPGGPS--EGKLIPGDQIVMIN 124
PP + + + R P LGF V G + P+ V++V G + +G+L GDQI+ +N
Sbjct: 1953 PPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVN 2012
Query: 125 DEPVSAAPRERVIDLVRSCKESILLTVI 152
+ + E + +++ K ++ L V+
Sbjct: 2013 GQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 40.4 bits (93), Expect = 0.011
Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 8/128 (6%)
Query: 56 TQAIPFDDPRLESCQIIPPAPRKVEMRRDPV-LGFGFVAGSEK---PVVVRSVTPGGPS- 110
T AI DP +C IIP +E+ + LG V GS+ +++ V G +
Sbjct: 1609 TPAIFASDPA--TCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAAC 1666
Query: 111 -EGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKA 169
+G+L GDQI+ +N + A + I+++R + + LT+ + K +
Sbjct: 1667 KDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTI 1726
Query: 170 RLKSNPVK 177
L+ P K
Sbjct: 1727 ELQKKPGK 1734
Score = 39.3 bits (90), Expect = 0.025
Identities = 31/101 (30%), Positives = 53/101 (52%), Gaps = 6/101 (5%)
Query: 79 VEMRRDPVLGFGF-VAG--SEKPVVVRSVTPGG--PSEGKLIPGDQIVMINDEPVSAAPR 133
+E+++ P G G + G ++ V V + GG ++G+L+ GDQI+M+N E V A +
Sbjct: 1726 IELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQ 1785
Query: 134 ERVIDLVRSCKESI-LLTVIQPYPSPKSAFISAAKKARLKS 173
E V L++ + S+ T S + S++KK L S
Sbjct: 1786 EAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALAS 1826
>gi|156938343 talin 2 [Homo sapiens]
Length = 2542
Score = 46.6 bits (109), Expect = 2e-04
Identities = 60/261 (22%), Positives = 111/261 (42%), Gaps = 42/261 (16%)
Query: 207 KVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLE----QRTEGAGT---- 258
K+ + +G K+ D S ++ ++++T+ ++ I E +SL+ E ++ EG GT
Sbjct: 91 KIRMLDGSVKTVMVDDSKTVGELLVTICSRIGITNYEEYSLIQETIEEKKEEGTGTLKKD 150
Query: 259 KLLLLHEQETLTQVTQRPSSHKMRCL-----FRISFVPKDPIDLLRR------------D 301
+ LL E++ + + + L FR V ++ LLRR D
Sbjct: 151 RTLLRDERKMEKLKAKLHTDDDLNWLDHSRTFREQGVDENETLLLRRKFFYSDQNVDSRD 210
Query: 302 PVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWG 361
PV LYVQ+ +D++ + ++ A Q I + + K+
Sbjct: 211 PVQLNLLYVQARDDILNGSH--PVSFEKACEFGGFQAQI-----QFGPHVEHKHKPGFLD 263
Query: 362 LETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGG 421
L+ FLP + +K++ +K + + ++N ++S ++AKV Y+K LR YG
Sbjct: 264 LKEFLPK---EYIKQRGAEK---RIFQEHKNC----GEMSEIEAKVKYVKLARSLRTYGV 313
Query: 422 RVFKATLVQAEKRSEVTLLVG 442
F K V L+G
Sbjct: 314 SFFLVKEKMKGKNKLVPRLLG 334
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 46.2 bits (108), Expect = 2e-04
Identities = 42/161 (26%), Positives = 69/161 (42%), Gaps = 26/161 (16%)
Query: 55 MTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVA--------GSEKPVVVRSVTP 106
+T+ P D + PP R++E++R P FGF G E R V
Sbjct: 197 VTKKFPVDLRLPPVVPLPPPTLRELELQRRPTGDFGFSLRRTTMLDRGPEGQACRRVVHF 256
Query: 107 GGPSEGK------LIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKS 160
P G L+PGD++V IN V + R+ +++++R +S+ L V QP P
Sbjct: 257 AEPGAGTKDLALGLVPGDRLVEINGHNVESKSRDEIVEMIRQSGDSVRLKV-QPIPE--- 312
Query: 161 AFISAAKKARLKS------NPVKVRFSEEVIINGQVSETVK 195
+S ++ L+S P + E++ +ET K
Sbjct: 313 --LSELSRSWLRSGEGPRREPSDAKTEEQIAAEEAWNETEK 351
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 46.2 bits (108), Expect = 2e-04
Identities = 42/161 (26%), Positives = 69/161 (42%), Gaps = 26/161 (16%)
Query: 55 MTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVA--------GSEKPVVVRSVTP 106
+T+ P D + PP R++E++R P FGF G E R V
Sbjct: 197 VTKKFPVDLRLPPVVPLPPPTLRELELQRRPTGDFGFSLRRTTMLDRGPEGQACRRVVHF 256
Query: 107 GGPSEGK------LIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKS 160
P G L+PGD++V IN V + R+ +++++R +S+ L V QP P
Sbjct: 257 AEPGAGTKDLALGLVPGDRLVEINGHNVESKSRDEIVEMIRQSGDSVRLKV-QPIPE--- 312
Query: 161 AFISAAKKARLKS------NPVKVRFSEEVIINGQVSETVK 195
+S ++ L+S P + E++ +ET K
Sbjct: 313 --LSELSRSWLRSGEGPRREPSDAKTEEQIAAEEAWNETEK 351
>gi|157738639 tensin 4 [Homo sapiens]
Length = 715
Score = 45.8 bits (107), Expect = 3e-04
Identities = 69/278 (24%), Positives = 109/278 (39%), Gaps = 39/278 (14%)
Query: 785 SLPPPEGDDNEDDFLLRSLNMAIAAPPPGFR----DSSDEEDSQSQAASFPEDKEKGSSL 840
+L PE D+ DF L SLN I P F+ + + +Q+ KE+ +L
Sbjct: 87 ALGTPEDLDSYIDFSLESLNQMILELDPTFQLLPPGTGGSQAELAQSTMSMRKKEESEAL 146
Query: 841 QNDEIPVSLIDAVPTSAEGKCEKGLDN----AVVSTLGALEA--LSVSEEQQTSDNSGVA 894
I V TSA +C G + +V G+L + L +S + S
Sbjct: 147 DIKYIEV-------TSARSRCHDGPQHCSSPSVTPPFGSLRSGGLLLSRDVPRETRS--- 196
Query: 895 ILRAYSPESSSDSGNETNSSE--MTESSELATAQKQSENLSRMFLATHEGY-HPLAEEQT 951
S ES SGN+ + + S L+ S ++S + + H L
Sbjct: 197 -----SSESLIFSGNQGRGHQRPLPPSEGLSPRPPNSPSISIPCMGSKASSPHGLGSPLV 251
Query: 952 EFPASKTPAGGLPPKSSH---ALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVT 1008
P + GGL P+ L+A P +D+ S+ LLHS + + + +S
Sbjct: 252 ASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPA 311
Query: 1009 DYFSKLH-MGSVAYSCT------SKRKSKLADGEGKAP 1039
+ S LH +GSV+ CT + R L G+ + P
Sbjct: 312 NSSSSLHSLGSVSL-CTRPSDFQAPRNPTLTMGQPRTP 348
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 45.1 bits (105), Expect = 5e-04
Identities = 22/54 (40%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 14 SHRTKSSGWPPPSGTWGLSQVP--PYGWEMTANRDGRDYFINHMTQAIPFDDPR 65
+H T+++ W P T G+ Q P P GWEM +G YF++H T+ F DPR
Sbjct: 424 NHNTRTTQWEDPR-TQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR 476
Score = 35.8 bits (81), Expect = 0.28
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 31 LSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMR 82
L +PP GWE + +GR Y++NH T+ ++DPR + P P EM+
Sbjct: 404 LGPLPP-GWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMK 453
Score = 33.5 bits (75), Expect = 1.4
Identities = 17/53 (32%), Positives = 26/53 (49%), Gaps = 9/53 (16%)
Query: 15 HRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLE 67
H TK++ W P +PP GWE + GR Y+++H T+ + P E
Sbjct: 321 HNTKTTTWERP--------LPP-GWEKRTDPRGRFYYVDHNTRTTTWQRPTAE 364
Score = 31.2 bits (69), Expect = 6.9
Identities = 25/76 (32%), Positives = 35/76 (46%), Gaps = 16/76 (21%)
Query: 23 PPPSGTWGL---SQVP---PYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAP 76
P SGT L +Q P P GWE +GR Y+++H T+ ++ P +PP
Sbjct: 284 PSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP-------LPPG- 335
Query: 77 RKVEMRRDPVLGFGFV 92
E R DP F +V
Sbjct: 336 --WEKRTDPRGRFYYV 349
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 44.7 bits (104), Expect = 6e-04
Identities = 23/66 (34%), Positives = 33/66 (50%), Gaps = 3/66 (4%)
Query: 14 SHRTKSSGWPPPSGTWGLSQVPPY--GWEMTANRDGRDYFINHMTQAIPFDDPRLESCQI 71
+H TK++ W P T GL P GWE+ R+G YF++H T+ F DPR +
Sbjct: 476 NHNTKTTQWEDPR-TQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSV 534
Query: 72 IPPAPR 77
P+
Sbjct: 535 TKGGPQ 540
Score = 41.2 bits (95), Expect = 0.007
Identities = 26/81 (32%), Positives = 36/81 (44%), Gaps = 7/81 (8%)
Query: 36 PYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGS 95
P GWE + R YF+NH T+ ++DPR + Q P P E+R FV +
Sbjct: 459 PPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHN 518
Query: 96 EKPVVVR-------SVTPGGP 109
+ + SVT GGP
Sbjct: 519 TRTTTFKDPRNGKSSVTKGGP 539
Score = 33.1 bits (74), Expect = 1.8
Identities = 17/49 (34%), Positives = 27/49 (55%), Gaps = 6/49 (12%)
Query: 36 PYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPA-PRKVEMRR 83
P GWE + GR Y+++H T+ ++ P Q +PP R+V+ RR
Sbjct: 352 PSGWEQRKDPHGRTYYVDHNTRTTTWERP-----QPLPPGWERRVDDRR 395
Score = 32.7 bits (73), Expect = 2.4
Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 7/54 (12%)
Query: 15 HRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLES 68
H T+++ W P Q P GWE + R Y+++H T+ + P +ES
Sbjct: 370 HNTRTTTWERP-------QPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMES 416
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 43.9 bits (102), Expect = 0.001
Identities = 25/75 (33%), Positives = 36/75 (48%), Gaps = 15/75 (20%)
Query: 15 HRTKSSGWPPP--------------SGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIP 60
H TK++ W P + L +PP GWE + DGR ++INH +
Sbjct: 442 HNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPP-GWEERTHTDGRIFYINHNIKRTQ 500
Query: 61 FDDPRLESCQIIPPA 75
++DPRLE+ I PA
Sbjct: 501 WEDPRLENVAITGPA 515
Score = 36.2 bits (82), Expect = 0.21
Identities = 14/32 (43%), Positives = 22/32 (68%)
Query: 36 PYGWEMTANRDGRDYFINHMTQAIPFDDPRLE 67
P GWE+ +GR +FI+H T+ ++DPRL+
Sbjct: 424 PKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLK 455
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 43.9 bits (102), Expect = 0.001
Identities = 25/75 (33%), Positives = 36/75 (48%), Gaps = 15/75 (20%)
Query: 15 HRTKSSGWPPP--------------SGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIP 60
H TK++ W P + L +PP GWE + DGR ++INH +
Sbjct: 789 HNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPP-GWEERTHTDGRIFYINHNIKRTQ 847
Query: 61 FDDPRLESCQIIPPA 75
++DPRLE+ I PA
Sbjct: 848 WEDPRLENVAITGPA 862
Score = 36.2 bits (82), Expect = 0.21
Identities = 14/32 (43%), Positives = 22/32 (68%)
Query: 36 PYGWEMTANRDGRDYFINHMTQAIPFDDPRLE 67
P GWE+ +GR +FI+H T+ ++DPRL+
Sbjct: 771 PKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLK 802
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,519,321
Number of Sequences: 37866
Number of extensions: 2629710
Number of successful extensions: 8037
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 189
Number of HSP's that attempted gapping in prelim test: 7351
Number of HSP's gapped (non-prelim): 716
length of query: 1322
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1208
effective length of database: 13,930,794
effective search space: 16828399152
effective search space used: 16828399152
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.