BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3 isoform 1 [Homo sapiens] (1059 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 2143 0.0 gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 2108 0.0 gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 1113 0.0 gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 951 0.0 gi|109150416 peroxidasin [Homo sapiens] 222 1e-57 gi|126517478 peroxidasin homolog-like [Homo sapiens] 212 2e-54 gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 159 1e-38 gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 159 1e-38 gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 155 2e-37 gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 153 7e-37 gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 149 2e-35 gi|198041768 synleurin [Homo sapiens] 147 7e-35 gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 145 2e-34 gi|225579152 insulin-like growth factor binding protein, acid la... 141 4e-33 gi|4826772 insulin-like growth factor binding protein, acid labi... 141 4e-33 gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 135 3e-31 gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 133 8e-31 gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 131 3e-30 gi|51317373 netrin-G1 ligand [Homo sapiens] 126 9e-29 gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 125 2e-28 gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 125 3e-28 gi|19743806 roundabout 1 isoform b [Homo sapiens] 124 4e-28 gi|4506569 roundabout 1 isoform a [Homo sapiens] 124 4e-28 gi|4758460 glycoprotein V (platelet) [Homo sapiens] 124 6e-28 gi|118572606 hemicentin 1 [Homo sapiens] 123 8e-28 gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 121 3e-27 gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 120 5e-27 gi|157694513 leucine-rich repeat-containing G protein-coupled re... 120 5e-27 gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 120 7e-27 gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 120 7e-27 >gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3 isoform 1 [Homo sapiens] Length = 1059 Score = 2143 bits (5552), Expect = 0.0 Identities = 1059/1059 (100%), Positives = 1059/1059 (100%) Query: 1 MVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS 60 MVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS Sbjct: 1 MVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS 60 Query: 61 ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT 120 ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT Sbjct: 61 ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT 120 Query: 121 SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA 180 SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA Sbjct: 121 SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA 180 Query: 181 LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 240 LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN Sbjct: 181 LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 240 Query: 241 RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS 300 RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS Sbjct: 241 RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS 300 Query: 301 LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN 360 LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN Sbjct: 301 LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN 360 Query: 361 AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG 420 AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG Sbjct: 361 AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG 420 Query: 421 RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL 480 RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL Sbjct: 421 RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL 480 Query: 481 LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN 540 LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN Sbjct: 481 LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN 540 Query: 541 MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV 600 MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV Sbjct: 541 MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV 600 Query: 601 FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA 660 FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA Sbjct: 601 FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA 660 Query: 661 GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV 720 GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV Sbjct: 661 GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV 720 Query: 721 RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC 780 RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC Sbjct: 721 RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC 780 Query: 781 SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT 840 SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT Sbjct: 781 SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT 840 Query: 841 CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY 900 CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY Sbjct: 841 CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY 900 Query: 901 EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL 960 EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL Sbjct: 901 EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL 960 Query: 961 DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG 1020 DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG Sbjct: 961 DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG 1020 Query: 1021 SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT 1059 SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT Sbjct: 1021 SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT 1059 >gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3 isoform 2 [Homo sapiens] Length = 1119 Score = 2108 bits (5462), Expect = 0.0 Identities = 1041/1044 (99%), Positives = 1043/1044 (99%) Query: 16 ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVE 75 ++R DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVE Sbjct: 76 VARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVE 135 Query: 76 ILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL 135 ILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL Sbjct: 136 ILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL 195 Query: 136 VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195 VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM Sbjct: 196 VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255 Query: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE Sbjct: 256 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 315 Query: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 315 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI Sbjct: 316 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 375 Query: 316 EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 375 EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK Sbjct: 376 EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 435 Query: 376 LQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDD 435 LQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDD Sbjct: 436 LQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDD 495 Query: 436 FPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQ 495 FPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQ Sbjct: 496 FPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQ 555 Query: 496 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR 555 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR Sbjct: 556 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR 615 Query: 556 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS Sbjct: 616 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 675 Query: 616 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS 675 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS Sbjct: 676 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS 735 Query: 676 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 735 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM Sbjct: 736 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 795 Query: 736 TAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIP 795 TAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIP Sbjct: 796 TAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIP 855 Query: 796 SYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAAT 855 SYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAAT Sbjct: 856 SYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAAT 915 Query: 856 DLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH 915 DLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH Sbjct: 916 DLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH 975 Query: 916 PSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSN 975 PSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSN Sbjct: 976 PSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSN 1035 Query: 976 SFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEEN 1035 SFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEEN Sbjct: 1036 SFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEEN 1095 Query: 1036 HICTFKQTLENYRTPNFQSYDLDT 1059 HICTFKQTLENYRTPNFQSYDLDT Sbjct: 1096 HICTFKQTLENYRTPNFQSYDLDT 1119 >gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2 [Homo sapiens] Length = 1065 Score = 1113 bits (2880), Expect = 0.0 Identities = 568/902 (62%), Positives = 705/902 (78%), Gaps = 13/902 (1%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79 D SHNRLS S S Q+L+EVK+N NEL IP G ++NITLLSL N I EI + Sbjct: 81 DFSHNRLSNWNISLES--QTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQ 138 Query: 80 HLKEFQSLETLDLSSNNISELQTA-FPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLK 138 L+ + +LE+LDLSSN ISE++T+ FP +QLKYL L++NR+T++E G FDNL+++LLV+K Sbjct: 139 ALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVK 198 Query: 139 LNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGA 198 LNRNR+S IPPK+FKLP LQ LEL RN+IK V+GLTFQGL +L+SLKMQRNG++KL DGA Sbjct: 199 LNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGA 258 Query: 199 FWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL 258 F+GL+NME L+L+HNNLT + KGWLYGL MLQ+L++SQNAI RISPDAWEFCQ+LSELDL Sbjct: 259 FFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDL 318 Query: 259 TFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDM 318 ++N L+RLD+S+F+GLSLL L++G+NRV++IAD FR LS+L+TLDL+NNEISW IED Sbjct: 319 SYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDA 378 Query: 319 NGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 378 + AF+GL L +LILQGN+I+SITKKAF GL++LEHLDL++NAIMS+Q NAFSQ L++ Sbjct: 379 SEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH-LKE 437 Query: 379 LHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPK 438 L LNTSSLLCDC LKWL QW+ +NNFQ VN SCAHP+ L G+SI V FVCDDF K Sbjct: 438 LILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLK 497 Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 PQI PET A++G N++ C+A SSSDSPM+ W+KD+E+L+D + EN+ Q GE Sbjct: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558 +EYT+IL L V F EGKYQC+++NHFGS+YS KAKLTVN +PSF KTPMDLTIR GA Sbjct: 558 ALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGA 617 Query: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618 MARLECAA GHPAPQI+WQKDGGTDFPAARERRMHVMPEDDVFFI +VKIED+G+YSC A Sbjct: 618 MARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMA 677 Query: 619 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 678 QN+AG +SANA+LTVLETPSF+RPL D+TVT+GETAVLQCIAGGSP P+LNWTKDD PL+ Sbjct: 678 QNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLL 737 Query: 679 VTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAP 738 VTERHFFAA NQLLIIVD+ + DAGKYTC MSNTLGTERG++ L+VI +P CDS Q ++ Sbjct: 738 VTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQ-SSI 796 Query: 739 SLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYL 798 +DDGW TVG+VII VVCCVVGTSL+WV++IYH RR+NED SITNT+E NLPADIPSYL Sbjct: 797 GHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYL 856 Query: 799 SSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHI--DNSSEADVEAATD 856 SSQGTL++ Q+GY +SE+GSH Q + + +GT I D A++ + T Sbjct: 857 SSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTR 916 Query: 857 LFLCPFLGSTGPMYLK---GNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPC 913 + CP+ L ++ P ETY P T ++ PS ++ +P Sbjct: 917 EY-CPYTYIAEEDVLDQTLSSLMVQMPKETYLV--HPPQDTTALESLIPSANREPSAFPT 973 Query: 914 SH 915 +H Sbjct: 974 NH 975 Score = 67.4 bits (163), Expect = 7e-11 Identities = 56/239 (23%), Positives = 108/239 (45%), Gaps = 30/239 (12%) Query: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIV 74 H+ +L NR+ ++ + L SLR +K+ N + + + N Sbjct: 216 HLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLN------------ 263 Query: 75 EILPEHLKEFQSLETLDLSSNNISELQTA--FPALQLKYLYLNSNRVTSMEPGYFDNLAN 132 ++E L+L NN++ + + L+ LY++ N + + P ++ Sbjct: 264 -----------NMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWE-FCQ 311 Query: 133 TLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 191 L L L+ N+++ + F L L+ L L N++ ++ F+ L L++L ++ N + Sbjct: 312 RLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEI 371 Query: 192 TKLMDG---AFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAW 247 + ++ AF GL+++ L L N + ITK GL L+ L L+ NAI I +A+ Sbjct: 372 SWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF 430 >gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1 [Homo sapiens] Length = 1093 Score = 951 bits (2459), Expect = 0.0 Identities = 515/984 (52%), Positives = 666/984 (67%), Gaps = 38/984 (3%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79 +LS+N+LS I + L +L+EV LNNNEL +P+LG S+++ L L N+I + Sbjct: 74 NLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGS 133 Query: 80 HLKEFQSLETLDLSSNNISELQ-TAFP-ALQLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137 LK + SLE LDLS NNI+E++ T FP +K L L NR+ ++E G FD L+ +LL L Sbjct: 134 QLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTL 193 Query: 138 KLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDG 197 +L++NRI+ +P + FKLP+L L+LNRN+I+ ++GLTFQGL +L+ LK+QRN ++KL DG Sbjct: 194 RLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDG 253 Query: 198 AFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELD 257 AFWGLS M +L L++N+L E+ G LYGL L +LHLS N+I RI W FCQKL EL Sbjct: 254 AFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELV 313 Query: 258 LTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIED 317 L+FN+L+RLD+ S LS L+ L + +N +S+IA+ AF+GL SL+ LDL +NEIS TIED Sbjct: 314 LSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373 Query: 318 MNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQ 377 +GAFSGLD L +L L GN+I+S+ K+AF+GL+ LEHL+L NAI S+Q +AF +MK L+ Sbjct: 374 TSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLK 433 Query: 378 QLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFP 437 +LH+++ S LCDCQLKWLP W+ Q+FV A+CAHP+ LKG+SIF+V P+ FVCDDF Sbjct: 434 ELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFL 493 Query: 438 KPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGG 497 KPQI QPET A+ G ++ F CSAASSS SPMTFAWKKDNE+L +A+MEN+ H+ AQ G Sbjct: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553 Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAG 557 EVMEYTTIL LR+V F EG+YQCVI+NHFGS+YS KA+LTVN+LPSFTKTP D+TIR Sbjct: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTT 613 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 MARLECAA GHP PQIAWQKDGGTDFPAARERRMHVMP+DDVFFI DVKI+D GVYSCT Sbjct: 614 TMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCT 673 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 AQNSAGSISANATLTVLETPS + PL DR V+ GET LQC A G+PPP++ W K D PL Sbjct: 674 AQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPL 733 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTA 737 +TERH NQLL++ + DAG+YTCEMSNTLGTER + +LSV+P C Sbjct: 734 SLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRK----- 788 Query: 738 PSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSY 797 DG TVG+ IAVV +V TSLVWV IIY TR+++E+ S+TNTDET +P D+PSY Sbjct: 789 -----DG-TTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSY 842 Query: 798 LSSQGTLADRQDGYVSSESGSH-HQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAATD 856 LSSQGTL+DRQ+ V +E G + + S+G H H + + A + Sbjct: 843 LSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSA 902 Query: 857 LFLCPFL------GSTGPMYLK--GNVYGSD---PFETYHTGCSPDPRTVLMDHYEPSYI 905 P+ G+ GP ++ G V SD + Y G + P+ V D +PS Sbjct: 903 YHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAP 962 Query: 906 KKKE----------CYPCSHPSEESCERSFSNISWPSHVRKLL---NTSYSHNEGPGMKN 952 E + CS + SC ++ +H R L + +G G + Sbjct: 963 NGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSS 1022 Query: 953 LCLNKSSLDFSANPEPASVASSNS 976 L + S +PAS +S S Sbjct: 1023 WTLARLYHPDSTELQPASSLTSGS 1046 Score = 124 bits (311), Expect = 5e-28 Identities = 156/648 (24%), Positives = 261/648 (40%), Gaps = 108/648 (16%) Query: 16 ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPV--SANITLLSLAGNRI 73 +++ DL+ NR+ I+ + L SL +KL N + + + G + + +L L N + Sbjct: 213 LTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTD-GAFWGLSKMHVLHLEYNSL 271 Query: 74 VEILPEHLKEFQSLETLDLSSNNISELQTAFPAL--QLKYLYLNSNRVTSMEPGYFDNLA 131 VE+ L +L L LS+N+I+ + + +L L L+ N +T ++ L Sbjct: 272 VEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAEL- 330 Query: 132 NTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNG 190 ++L VL+L+ N IS I FK L L+ L+L+ N+I +G Sbjct: 331 SSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI---------------------SG 369 Query: 191 VTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC 250 + GAF GL ++ L L N + + K GL L+ L+L NAI + DA Sbjct: 370 TIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDA---- 425 Query: 251 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 310 F+ + L LHI ++ S++ DC + L Sbjct: 426 --------------------FVKMKNLKELHISSD--SFLCDCQLKWLP----------- 452 Query: 311 ISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALE-HLDLSDNAIMSLQGNA 369 W I M AF L+G I S+ ++F D L+ + M++ G Sbjct: 453 -PWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVG-- 509 Query: 370 FSQMKKLQQLHLNTSSLLCDCQLKWLP--QWVAENNFQSFVNASCAHPQLLKGRSIF--- 424 K ++ SS W + + + ++FV+ ++++ +I Sbjct: 510 ----KDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLR 565 Query: 425 -----------AVSPDGFVCDDFPKPQITV-------QPETQSAIKGSNLSFICSAASSS 466 V + F K ++TV + I+ + ++ + AA+ Sbjct: 566 QVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGH 625 Query: 467 DSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNH 526 +P AW+KD A E H VM + + +V+ G Y C N Sbjct: 626 PNPQ-IAWQKDGGTDFPAARERRMH-------VMPDDDVFFITDVKIDDAGVYSCTAQNS 677 Query: 527 FGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPA 586 G S S A LTV PS D + G L+C A G+P P+I W K D P Sbjct: 678 AG-SISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKG---DRPL 733 Query: 587 ARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVL 634 + R H+ P++ + + +V ED G Y+C N+ G+ A++ L+VL Sbjct: 734 SLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVL 781 Score = 44.7 bits (104), Expect = 5e-04 Identities = 37/115 (32%), Positives = 62/115 (53%), Gaps = 6/115 (5%) Query: 9 SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELE-TIPNLGPVSA---NIT 64 SL L +S LSHN +S I + L+SLR + L++NE+ TI + + +++ Sbjct: 326 SLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLS 385 Query: 65 LLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAFPALQ-LKYLYLNSN 117 L+L GN+I + + LE L+L N I +Q AF ++ LK L+++S+ Sbjct: 386 KLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSD 440 >gi|109150416 peroxidasin [Homo sapiens] Length = 1479 Score = 222 bits (566), Expect = 1e-57 Identities = 153/505 (30%), Positives = 247/505 (48%), Gaps = 37/505 (7%) Query: 232 LHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIA 291 +HL A+ ++P S LDL FN + + +F L LNTL + NN++ I Sbjct: 50 MHLLLEAVPAVAPQT-------SILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIP 102 Query: 292 DCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDA 351 AF L +LK L L NEI +I+ AF GL L +L L N+I ++ +F L Sbjct: 103 SGAFEDLENLKYLYLYKNEIQ-SIDRQ--AFKGLASLEQLYLHFNQIETLDPDSFQHLPK 159 Query: 352 LEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQ----WVAENNFQSF 407 LE L L +N I L F+ ++ +++L L++++L CDC++ WL + N Q+ Sbjct: 160 LERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAA 219 Query: 408 VNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSD 467 A C +P+ ++GRS+ ++P+ C+ +P+IT +P+ G+ + F C A + Sbjct: 220 --AICEYPRRIQGRSVATITPEELNCE---RPRITSEPQDADVTSGNTVYFTCRA-EGNP 273 Query: 468 SPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHF 527 P + +NEL + ++ +L G L ++ + +G YQC+ N Sbjct: 274 KPEIIWLRNNNEL--SMKTDSRLNLLDDG--------TLMIQNTQETDQGIYQCMAKNVA 323 Query: 528 GSSYSVKAKLTV---NMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDF 584 G + + L P+F P + + G LEC+A GHP P+I+W + T Sbjct: 324 GEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPL 383 Query: 585 PAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLL 644 P + R+++ P ++ I +V D G Y+C+A N+ S+ A A + V P F Sbjct: 384 PV--DPRVNITPSGGLY-IQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQ 440 Query: 645 DRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGK 704 DR V +G+T QC A G+PPP + WTK S L V RH + L I + D G+ Sbjct: 441 DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLR-ISGVALHDQGQ 499 Query: 705 YTCEMSNTLGTERGNVRLSVIPTPT 729 Y C+ N +G+++ L+V P T Sbjct: 500 YECQAVNIIGSQKVVAHLTVQPRVT 524 Score = 157 bits (398), Expect = 4e-38 Identities = 158/592 (26%), Positives = 245/592 (41%), Gaps = 65/592 (10%) Query: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 243 L ++ N + ++ GAF L N+ L L++N + I G L L+ L+L +N I I Sbjct: 67 LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126 Query: 244 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 303 A++ L +L L FN + LD SF L L L + NNR++++ F L S+K Sbjct: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKR 186 Query: 304 LDLKNN------EISWTI-------EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLD 350 L L +N EI W E N + + + R I QG + +IT + Sbjct: 187 LRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRI-QGRSVATITPEELNCER 245 Query: 351 ALEHLDLSDNAIMS---------LQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP----- 396 + D + S +GN ++ L+ + N S+ D +L L Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLR--NNNELSMKTDSRLNLLDDGTLM 303 Query: 397 ----QWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIK 452 Q + +Q + + + SP +P +QP+ + Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP--------ARPTFVIQPQNTEVLV 355 Query: 453 GSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVE 512 G +++ CSA + P +W + + ++ ++ GG L ++ V Sbjct: 356 GESVTLECSA--TGHPPPRISWTRGDRT--PLPVDPRVNITPSGG--------LYIQNVV 403 Query: 513 FASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAP 572 G+Y C +N+ S ++ A + V LP FT TP D + G +C A G+P P Sbjct: 404 QGDSGEYACSATNNIDSVHAT-AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPP 462 Query: 573 QIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLT 632 IAW K GG+ R H++ I V + D G Y C A N GS A LT Sbjct: 463 VIAWTK-GGSQLSVDRR---HLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLT 518 Query: 633 VLE--TPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTER-HFFAAGN 689 V TP F D TV G L C + G P P + W KD + VTE F + Sbjct: 519 VQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG--VQVTESGKFHISPE 576 Query: 690 QLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-IPTPTCDSPQMTAPSL 740 L I D +DAG+Y C NT+G+ ++ LSV +P + + A S+ Sbjct: 577 GFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSI 628 Score = 71.2 bits (173), Expect = 5e-12 Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 4/144 (2%) Query: 100 LQTAFPAL--QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQ 156 L A PA+ Q L L NR+ ++PG F L N L L LN N+I IP F+ L Sbjct: 53 LLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRN-LNTLLLNNNQIKRIPSGAFEDLEN 111 Query: 157 LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT 216 L++L L +N+I+++D F+GL +L+ L + N + L +F L +E L L +N +T Sbjct: 112 LKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRIT 171 Query: 217 EITKGWLYGLLMLQELHLSQNAIN 240 + G L ++ L L N ++ Sbjct: 172 HLVPGTFNHLESMKRLRLDSNTLH 195 Score = 55.5 bits (132), Expect = 3e-07 Identities = 44/129 (34%), Positives = 71/129 (55%), Gaps = 6/129 (4%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEIL 77 DL NR+ I+ + L++L + LNNN+++ IP+ G N+ L L N I I Sbjct: 68 DLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPS-GAFEDLENLKYLYLYKNEIQSID 126 Query: 78 PEHLKEFQSLETLDLSSNNISELQ-TAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL 135 + K SLE L L N I L +F L +L+ L+L++NR+T + PG F++L ++ Sbjct: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL-ESMK 185 Query: 136 VLKLNRNRI 144 L+L+ N + Sbjct: 186 RLRLDSNTL 194 >gi|126517478 peroxidasin homolog-like [Homo sapiens] Length = 1463 Score = 212 bits (539), Expect = 2e-54 Identities = 144/481 (29%), Positives = 234/481 (48%), Gaps = 28/481 (5%) Query: 251 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 310 Q+ + LDL FN + + S+F L LNTL + NN + I+ AF GL +L L L NE Sbjct: 50 QQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109 Query: 311 ISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF 370 I + F GL L L + N++ + + F L LE L L +N + + +F Sbjct: 110 IHALDKQ---TFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSF 166 Query: 371 SQMKKLQQLHLNTSSLLCDCQLKWLPQWVA--ENNFQSFVNASCAHPQLLKGRSIFAVSP 428 S + L++L L++++L+CDC L WL + + + + A+C +P+ L GR++ +V+ Sbjct: 167 SNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTV 226 Query: 429 DGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMEN 488 + F C P+IT +P+ G+ + F C A + + W +N H ++E+ Sbjct: 227 EEFNCQ---SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEI--IWIHNN---HSLDLED 278 Query: 489 YAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML---PSF 545 L V + T++ +R + +G YQC+ N G + + A L + L PSF Sbjct: 279 DTRL-----NVFDDGTLM-IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSF 332 Query: 546 TKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVD 605 P D + G LEC A GHP P I W +D G + +R HV + ++ + Sbjct: 333 VIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSR----HVATSSGL-YLQN 387 Query: 606 VKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPP 665 + D G ++C A NS G++ A A + V P F D+ V + C A G+PP Sbjct: 388 ITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPP 447 Query: 666 PKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVI 725 P + WTK L V +H + L I + D G+Y C+ ++LG ++ +V+L+V Sbjct: 448 PVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ-HDQGQYECQAVSSLGVKKVSVQLTVK 506 Query: 726 P 726 P Sbjct: 507 P 507 Score = 128 bits (321), Expect = 3e-29 Identities = 145/600 (24%), Positives = 231/600 (38%), Gaps = 92/600 (15%) Query: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219 L+L N+I+ + G F+ L L +L + N + K+ AF GL N+ L L N + + Sbjct: 55 LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114 Query: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 279 K GL+ L+ L++ N + + P+ TF L RL+ Sbjct: 115 KQTFKGLISLEHLYIHFNQLEMLQPE-------------TFGDLLRLE-----------R 150 Query: 280 LHIGNNRVSYIADCAFRGLSSLKTLDLKNN------EISWTIEDMNG--------AFSGL 325 L + NN++S I +F L SLK L L +N ++ W E + G A + Sbjct: 151 LFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATC 210 Query: 326 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF--------SQMKKLQ 377 + RRL G + S+T + F + D + S GN + ++ Sbjct: 211 EYPRRL--HGRAVASVTVEEFNCQSPRITFEPQDVEVPS--GNTVYFTCRAEGNPKPEII 266 Query: 378 QLHLNTS-SLLCDCQLKWLPQWVA---------ENNFQSFVNASCAHPQLLKGRSIFAVS 427 +H N S L D +L + +Q S + ++ Sbjct: 267 WIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSL 326 Query: 428 PDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEME 487 P KP +QP+ + G++ + C A +T W +DN L E++ Sbjct: 327 P--------AKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLIT--WTRDNGL----ELD 372 Query: 488 NYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTK 547 H+ G L L+ + G++ C +N G+ + A + V P FT Sbjct: 373 GSRHVATSSG--------LYLQNITQRDHGRFTCHANNSHGTVQAA-ANIIVQAPPQFTV 423 Query: 548 TPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVK 607 TP D + C A G+P P I W K GG P + H + I Sbjct: 424 TPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGG-QLPVEGQ---HTVLSSGTLRIDRAA 479 Query: 608 IEDIGVYSCTAQNSAG--SISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPP 665 D G Y C A +S G +S T+ F + D +V G+ + C A G P Sbjct: 480 QHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQ 539 Query: 666 PKLNWTKDDSPLVVTERHFFAAGNQ-LLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724 P + W K+ + +TE F ++ L I D+ D G+Y C N+ G N+ L+V Sbjct: 540 PIITWNKEG--VQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597 Score = 90.1 bits (222), Expect = 1e-17 Identities = 97/414 (23%), Positives = 162/414 (39%), Gaps = 65/414 (15%) Query: 331 LILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDC 390 L L+ NRIR I AF L L L L++N I + NAF ++ L L+L + + Sbjct: 55 LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114 Query: 391 QLKWLPQWVAENNFQSFVNASCAHPQ----LLKGRSIFAVSPDGFVCDDFPKPQITVQPE 446 + + E+ + F P+ LL+ +F Sbjct: 115 KQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLF---------------------- 152 Query: 447 TQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEM-------ENYA-HLRAQGGE 498 + + LS I + + S+ + N L+ D ++ + +A H Q Sbjct: 153 ----LHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAA 208 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558 EY L R V + ++ C P T P D+ + +G Sbjct: 209 TCEYPRRLHGRAVASVTVEEFNC-------------------QSPRITFEPQDVEVPSGN 249 Query: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618 C A G+P P+I W + + + R++V +D I + + D GVY C A Sbjct: 250 TVYFTCRAEGNPKPEIIWIHNNHS-LDLEDDTRLNVF-DDGTLMIRNTRESDQGVYQCMA 307 Query: 619 QNSAGSISANATL----TVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDD 674 +NSAG + + ++ PSF+ D V G + L+C+A G P P + WT+D+ Sbjct: 308 RNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDN 367 Query: 675 SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 + RH A + L + + D G++TC +N+ GT + + V P Sbjct: 368 GLELDGSRH--VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPP 419 Score = 61.2 bits (147), Expect = 5e-09 Identities = 44/142 (30%), Positives = 79/142 (55%), Gaps = 4/142 (2%) Query: 53 IPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LK 110 + ++ V T+L L NRI EI K+ ++L TL L++N+I ++ + AF L+ L Sbjct: 42 LDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLL 101 Query: 111 YLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKN 169 YLYL N + +++ F L +L L ++ N++ + P+ F L +L+ L L+ NK+ Sbjct: 102 YLYLYKNEIHALDKQTFKGLI-SLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSK 160 Query: 170 VDGLTFQGLGALKSLKMQRNGV 191 + +F L +LK L++ N + Sbjct: 161 IPAGSFSNLDSLKRLRLDSNAL 182 Score = 50.4 bits (119), Expect = 9e-06 Identities = 41/128 (32%), Positives = 66/128 (51%), Gaps = 4/128 (3%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEILP 78 DL NR+ I S+ L++L + LNNN + I N N+ L L N I + Sbjct: 56 DLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDK 115 Query: 79 EHLKEFQSLETLDLSSNNISELQ--TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLV 136 + K SLE L + N + LQ T L+L+ L+L++N+++ + G F NL ++L Sbjct: 116 QTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNL-DSLKR 174 Query: 137 LKLNRNRI 144 L+L+ N + Sbjct: 175 LRLDSNAL 182 >gi|205277468 leucine rich repeat containing 15 isoform a [Homo sapiens] Length = 587 Score = 159 bits (402), Expect = 1e-38 Identities = 128/437 (29%), Positives = 218/437 (49%), Gaps = 23/437 (5%) Query: 23 HNRLSFIKASSMSHLQSLREVKLNNNELETIP-----NLGPVSANITLLSLAGNRIVEIL 77 + ++ + S ++ +L +++ NEL I NLG ++ LSLA N++ ++L Sbjct: 68 NTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLG----SLRYLSLANNKL-QVL 122 Query: 78 PEHLKE-FQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTL 134 P L + SLE+L LSSN + ++Q A LK L L+ N + + G FD+L L Sbjct: 123 PIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-L 181 Query: 135 LVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 193 L L +N ++ I P++F+ L LQ L L N++ ++ TF GL L+ L +Q+N + Sbjct: 182 TKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGL 241 Query: 194 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 253 L G F N++ L L +N+++++ L L L L N++ +S + L Sbjct: 242 LSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNL 301 Query: 254 SELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISW 313 EL L NH+S L D+ F L L L + N++S+I+ AF GL+ L+ L L N Sbjct: 302 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN---- 357 Query: 314 TIEDMNG-AFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQ 372 ++D++G F L L+ + LQ NR+R + F ++ L + L +N + +L F Sbjct: 358 ALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDH 417 Query: 373 MKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNA--SCAHPQLLKGRSIFAVSPDG 430 + KL +L L + CD + L W+ N + + C P ++G+S+ ++ + Sbjct: 418 LGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNV 477 Query: 431 FVCDDFPKPQITVQPET 447 V P++ PET Sbjct: 478 AV-PSVHVPEVPSYPET 493 Score = 143 bits (361), Expect = 7e-34 Identities = 110/348 (31%), Positives = 172/348 (49%), Gaps = 9/348 (2%) Query: 42 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 101 +V+ + +P P+ N L + I E+ +L L + N +S + Sbjct: 42 QVECTGARIVAVPT--PLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRIT 99 Query: 102 T-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQ 158 AF L L+YL L +N++ + G F L ++L L L+ N++ I P F + L+ Sbjct: 100 PGAFRNLGSLRYLSLANNKLQVLPIGLFQGL-DSLESLLLSSNQLLQIQPAHFSQCSNLK 158 Query: 159 HLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEI 218 L+L+ N ++ + F L L L + +N +T + F L N+++L+L N LT+I Sbjct: 159 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 218 Query: 219 TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN 278 G GL+ LQEL L QN I +SP + L L L+ NH+S+L S F+ L LN Sbjct: 219 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 278 Query: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338 L + N + ++ F + +L+ L L +N IS ++ D FS L +L+ LIL N+I Sbjct: 279 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS-SLPD--NVFSNLRQLQVLILSRNQI 335 Query: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386 I+ AF GL L L L NA+ L GN F + LQ + L + L Sbjct: 336 SFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 383 Score = 140 bits (352), Expect = 8e-33 Identities = 112/381 (29%), Positives = 183/381 (48%), Gaps = 9/381 (2%) Query: 9 SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSL 68 S C S+ + + R+ + + SL+ + + EL P L +SA I L + Sbjct: 33 SECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLN-ISALIAL-RI 90 Query: 69 AGNRIVEILPEHLKEFQSLETLDLSSNNISELQTA-FPALQ-LKYLYLNSNRVTSMEPGY 126 N + I P + SL L L++N + L F L L+ L L+SN++ ++P + Sbjct: 91 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 150 Query: 127 FDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLK 185 F +N L L+L+ N + IP F L L L L +N + ++ FQ LG L+ L+ Sbjct: 151 FSQCSN-LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 209 Query: 186 MQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPD 245 + N +T + G F GL N++ L L N + ++ G + LQ L+LS N I+++ P Sbjct: 210 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 269 Query: 246 AWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLD 305 + +L+ L L N L L F + L L + +N +S + D F L L+ L Sbjct: 270 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLI 329 Query: 306 LKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSL 365 L N+IS+ GAF+GL +LR L L N ++ + F L L+++ L +N + L Sbjct: 330 LSRNQISFISP---GAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQL 386 Query: 366 QGNAFSQMKKLQQLHLNTSSL 386 GN F+ + L + L + L Sbjct: 387 PGNIFANVNGLMAIQLQNNQL 407 Score = 119 bits (297), Expect = 2e-26 Identities = 108/345 (31%), Positives = 164/345 (47%), Gaps = 34/345 (9%) Query: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEILPE 79 + N LS I + +L SLR + L NN+L+ +P L ++ L L+ N++++I P Sbjct: 90 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149 Query: 80 HLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVL 137 H + +L+ L L N++ + AF L L L L N +T + P F +L N L VL Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN-LQVL 208 Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196 +L NR++ IP F L LQ L L +N+I + F L+ L + N +++L Sbjct: 209 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 268 Query: 197 GAFWGLSNMEILQLDHNNLTEITKG-----------WLY-------------GLLMLQEL 232 F L + L L N+L E++ G WLY L LQ L Sbjct: 269 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 328 Query: 233 HLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIAD 292 LS+N I+ ISP A+ +L EL L N L LD + F L+ L + + NNR+ + Sbjct: 329 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 388 Query: 293 CAFRGLSSLKTLDLKNNEISWTIEDMN-GAFSGLDKLRRLILQGN 336 F ++ L + L+NN+ +E++ G F L KL L L N Sbjct: 389 NIFANVNGLMAIQLQNNQ----LENLPLGIFDHLGKLCELRLYDN 429 >gi|18677767 leucine rich repeat containing 15 isoform b [Homo sapiens] Length = 581 Score = 159 bits (402), Expect = 1e-38 Identities = 128/437 (29%), Positives = 218/437 (49%), Gaps = 23/437 (5%) Query: 23 HNRLSFIKASSMSHLQSLREVKLNNNELETIP-----NLGPVSANITLLSLAGNRIVEIL 77 + ++ + S ++ +L +++ NEL I NLG ++ LSLA N++ ++L Sbjct: 62 NTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLG----SLRYLSLANNKL-QVL 116 Query: 78 PEHLKE-FQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTL 134 P L + SLE+L LSSN + ++Q A LK L L+ N + + G FD+L L Sbjct: 117 PIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-L 175 Query: 135 LVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 193 L L +N ++ I P++F+ L LQ L L N++ ++ TF GL L+ L +Q+N + Sbjct: 176 TKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGL 235 Query: 194 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 253 L G F N++ L L +N+++++ L L L L N++ +S + L Sbjct: 236 LSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNL 295 Query: 254 SELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISW 313 EL L NH+S L D+ F L L L + N++S+I+ AF GL+ L+ L L N Sbjct: 296 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN---- 351 Query: 314 TIEDMNG-AFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQ 372 ++D++G F L L+ + LQ NR+R + F ++ L + L +N + +L F Sbjct: 352 ALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDH 411 Query: 373 MKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNA--SCAHPQLLKGRSIFAVSPDG 430 + KL +L L + CD + L W+ N + + C P ++G+S+ ++ + Sbjct: 412 LGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNV 471 Query: 431 FVCDDFPKPQITVQPET 447 V P++ PET Sbjct: 472 AV-PSVHVPEVPSYPET 487 Score = 143 bits (361), Expect = 7e-34 Identities = 110/348 (31%), Positives = 172/348 (49%), Gaps = 9/348 (2%) Query: 42 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 101 +V+ + +P P+ N L + I E+ +L L + N +S + Sbjct: 36 QVECTGARIVAVPT--PLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRIT 93 Query: 102 T-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQ 158 AF L L+YL L +N++ + G F L ++L L L+ N++ I P F + L+ Sbjct: 94 PGAFRNLGSLRYLSLANNKLQVLPIGLFQGL-DSLESLLLSSNQLLQIQPAHFSQCSNLK 152 Query: 159 HLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEI 218 L+L+ N ++ + F L L L + +N +T + F L N+++L+L N LT+I Sbjct: 153 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 212 Query: 219 TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN 278 G GL+ LQEL L QN I +SP + L L L+ NH+S+L S F+ L LN Sbjct: 213 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 272 Query: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338 L + N + ++ F + +L+ L L +N IS ++ D FS L +L+ LIL N+I Sbjct: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS-SLPD--NVFSNLRQLQVLILSRNQI 329 Query: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386 I+ AF GL L L L NA+ L GN F + LQ + L + L Sbjct: 330 SFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 377 Score = 140 bits (352), Expect = 8e-33 Identities = 112/381 (29%), Positives = 183/381 (48%), Gaps = 9/381 (2%) Query: 9 SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSL 68 S C S+ + + R+ + + SL+ + + EL P L +SA I L + Sbjct: 27 SECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLN-ISALIAL-RI 84 Query: 69 AGNRIVEILPEHLKEFQSLETLDLSSNNISELQTA-FPALQ-LKYLYLNSNRVTSMEPGY 126 N + I P + SL L L++N + L F L L+ L L+SN++ ++P + Sbjct: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144 Query: 127 FDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLK 185 F +N L L+L+ N + IP F L L L L +N + ++ FQ LG L+ L+ Sbjct: 145 FSQCSN-LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203 Query: 186 MQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPD 245 + N +T + G F GL N++ L L N + ++ G + LQ L+LS N I+++ P Sbjct: 204 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263 Query: 246 AWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLD 305 + +L+ L L N L L F + L L + +N +S + D F L L+ L Sbjct: 264 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLI 323 Query: 306 LKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSL 365 L N+IS+ GAF+GL +LR L L N ++ + F L L+++ L +N + L Sbjct: 324 LSRNQISFISP---GAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQL 380 Query: 366 QGNAFSQMKKLQQLHLNTSSL 386 GN F+ + L + L + L Sbjct: 381 PGNIFANVNGLMAIQLQNNQL 401 Score = 119 bits (297), Expect = 2e-26 Identities = 108/345 (31%), Positives = 164/345 (47%), Gaps = 34/345 (9%) Query: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEILPE 79 + N LS I + +L SLR + L NN+L+ +P L ++ L L+ N++++I P Sbjct: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143 Query: 80 HLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVL 137 H + +L+ L L N++ + AF L L L L N +T + P F +L N L VL Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN-LQVL 202 Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196 +L NR++ IP F L LQ L L +N+I + F L+ L + N +++L Sbjct: 203 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 262 Query: 197 GAFWGLSNMEILQLDHNNLTEITKG-----------WLY-------------GLLMLQEL 232 F L + L L N+L E++ G WLY L LQ L Sbjct: 263 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 322 Query: 233 HLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIAD 292 LS+N I+ ISP A+ +L EL L N L LD + F L+ L + + NNR+ + Sbjct: 323 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 382 Query: 293 CAFRGLSSLKTLDLKNNEISWTIEDMN-GAFSGLDKLRRLILQGN 336 F ++ L + L+NN+ +E++ G F L KL L L N Sbjct: 383 NIFANVNGLMAIQLQNNQ----LENLPLGIFDHLGKLCELRLYDN 423 >gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo sapiens] Length = 593 Score = 155 bits (391), Expect = 2e-37 Identities = 158/499 (31%), Positives = 240/499 (48%), Gaps = 37/499 (7%) Query: 68 LAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQ--LKYLYLNSNRVTSMEPG 125 L G+R +E +P L E LDLS N + LQ + L+ L L+ N+++++EPG Sbjct: 45 LCGHRQLEAVPGGLP--LDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPG 102 Query: 126 YFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSL 184 F L +LL L+L NR+ + P +F L L L+L N+I F LG+L+ L Sbjct: 103 AFHGL-QSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKL 161 Query: 185 KMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 244 ++ N + + GAF GL+ + L L+ NL+ + L L L L L + I R+ Sbjct: 162 EVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPA 221 Query: 245 DAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 303 A +L EL++ + L LD S +GL+L ++L I +S + A LS L+ Sbjct: 222 GALRGLGQLKELEIHLWPSLEALDPGSLVGLNL-SSLAITRCNLSSVPFQALYHLSFLRV 280 Query: 304 LDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIM 363 LDL N IS S L +L+ L L G + SI AF GL A LD++DNA+ Sbjct: 281 LDLSQNPISAIPARR---LSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 337 Query: 364 SLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 423 +L+ AF KL L L+ + L CDC+L WL + +F +CA P ++G+S+ Sbjct: 338 TLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDF-GMSPPACAGPHHVQGKSL 396 Query: 424 FAVS----PDGFVCDDFPKPQITVQ--PETQSAIKGSNLSFICSAASSSDSPMTFAWKKD 477 S P F C KP + + P A +G + F CS D T +W + Sbjct: 397 KEFSDILPPGHFTC----KPALIRKSGPRWVIAEEGGHAVFSCS--GDGDPAPTVSWMRP 450 Query: 478 NELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKL 537 H A + +R V+E T L +R V+ G Y CV+SN G+ S++ L Sbjct: 451 ----HGAWLGRAGRVR-----VLEDGT-LEIRSVQLRDRGAYVCVVSNVAGND-SLRTWL 499 Query: 538 TVNML--PSFTKTPMDLTI 554 V + P+ T + ++T+ Sbjct: 500 EVIQVEPPNGTLSDPNITV 518 Score = 97.4 bits (241), Expect = 6e-20 Identities = 93/298 (31%), Positives = 141/298 (47%), Gaps = 7/298 (2%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILP 78 DLS NRL ++ +S L L+E+ L+ N+L T+ P ++ L L GNR+ + P Sbjct: 66 DLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGP 125 Query: 79 EHLKEFQSLETLDLSSNNI-SELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLV 136 +L LDL N I L AF L L+ L + N + + PG F LA L Sbjct: 126 GVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAK-LST 184 Query: 137 LKLNRNRISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195 L L R +S +P + +LP L L L I + +GLG LK L++ + + Sbjct: 185 LTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEAL 244 Query: 196 D-GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLS 254 D G+ GL N+ L + NL+ + LY L L+ L LSQN I+ I +L Sbjct: 245 DPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQ 303 Query: 255 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS 312 EL L+ L+ + +F GL+ + L + +N + + + AF L TL L N ++ Sbjct: 304 ELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361 Score = 94.4 bits (233), Expect = 5e-19 Identities = 125/478 (26%), Positives = 185/478 (38%), Gaps = 57/478 (11%) Query: 206 EILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 265 E+L L N L + +G L L +LQEL LS N ++ + P A+ Q L L L N L Sbjct: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122 Query: 266 LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGL 325 + F GLS L L + N++ D AF L SL+ L++ +N + + GAF+GL Sbjct: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAP---GAFAGL 179 Query: 326 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLH----- 380 KL L L+ + ++ A L AL L L + I L A + +L++L Sbjct: 180 AKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWP 239 Query: 381 ------------LNTSSL-LCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVS 427 LN SSL + C L +P FQ+ + S L I A+ Sbjct: 240 SLEALDPGSLVGLNLSSLAITRCNLSSVP-------FQALYHLSFLRVLDLSQNPISAIP 292 Query: 428 PDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEM- 486 P + +Q + + G+ L+ I + A + DN L E Sbjct: 293 ARRL------SPLVRLQ---ELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETA 343 Query: 487 ----ENYAHLRAQGGEVM---EYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 539 + LR G + +LRLR C +H S+K + Sbjct: 344 FPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGK-SLKEFSDI 402 Query: 540 NMLPSFT--------KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERR 591 FT P + G A C+ G PAP ++W + G R R Sbjct: 403 LPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAGR 460 Query: 592 MHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT 649 + V+ ED I V++ D G Y C N AG+ S L V++ L D +T Sbjct: 461 VRVL-EDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNIT 517 Score = 39.7 bits (91), Expect = 0.015 Identities = 25/95 (26%), Positives = 36/95 (37%), Gaps = 4/95 (4%) Query: 650 KGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEM 709 +G AV C G P P ++W + + + L I + D G Y C + Sbjct: 427 EGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVV 486 Query: 710 SNTLGTERGNVRLSVI----PTPTCDSPQMTAPSL 740 SN G + L VI P T P +T P + Sbjct: 487 SNVAGNDSLRTWLEVIQVEPPNGTLSDPNITVPGI 521 Score = 34.3 bits (77), Expect = 0.64 Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 5/110 (4%) Query: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP--NLGPVSANITLLSLAGNR 72 ++S ++ LS + ++ HL LR + L+ N + IP L P+ + L L+G Sbjct: 253 NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPL-VRLQELRLSGAC 311 Query: 73 IVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVT 120 + I + LD++ N + L +TAFP+ +L L L+ N +T Sbjct: 312 LTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361 >gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo sapiens] Length = 606 Score = 153 bits (387), Expect = 7e-37 Identities = 154/525 (29%), Positives = 232/525 (44%), Gaps = 56/525 (10%) Query: 41 REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 100 + V + L IP P+ I L L+ NR+ + PE + LE +DLS N I+ Sbjct: 39 KSVSCHRRRLIAIPEGIPIETKI--LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIA-- 94 Query: 101 QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 159 ++EPG F+NL N L L+L NR+ +P +F L L Sbjct: 95 --------------------NVEPGAFNNLFN-LRSLRLKGNRLKLVPLGVFTGLSNLTK 133 Query: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219 L+++ NKI + FQ L LKSL++ N + + AF GL ++E L L+ NLT + Sbjct: 134 LDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVP 193 Query: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTF-NHLSRLDDSSFLGLSLLN 278 L L L LHL IN + A++ L L++ + L + +S GL+L Sbjct: 194 TEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNL-T 252 Query: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338 +L + N +S + AF+ L L L+L N IS TIE G FS L +L+ L + G ++ Sbjct: 253 SLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPIS-TIEA--GMFSDLIRLQELHIVGAQL 309 Query: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398 R+I +F GL L L++S N + +L+ N FS + L+ L +N + L CDC+L W+ Q Sbjct: 310 RTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQR 369 Query: 399 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDG----FVCDDFPKPQITVQPETQSAI-KG 453 F CA P ++ RS F C KP+I + + +G Sbjct: 370 QPTLQFGG-QQPMCAGPDTIRERSFKDFHSTALSFYFTC---KKPKIREKKLQHLLVDEG 425 Query: 454 SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEF 513 + CSA D +W + A + G L +R + Sbjct: 426 QTVQLECSA--DGDPQPVISWVTPRRRFITTKSNGRATVLGDG--------TLEIRFAQD 475 Query: 514 ASEGKYQCVISNHFGSSYSVKAKLTVNMLPS-----FTKTPMDLT 553 G Y C+ SN G+ + A LTV S +TPM +T Sbjct: 476 QDSGMYVCIASNAAGND-TFTASLTVKGFASDRFLYANRTPMYMT 519 Score = 77.4 bits (189), Expect = 7e-14 Identities = 77/305 (25%), Positives = 135/305 (44%), Gaps = 21/305 (6%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILP 78 DLS NRL + L E+ L++N + + P N+ L L GNR+ + Sbjct: 63 DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPL 122 Query: 79 EHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPG-----YFDNLANT 133 +L LD+S N I + L Y++ + + + S+E G Y + A + Sbjct: 123 GVFTGLSNLTKLDISENKI--------VILLDYMFQDLHNLKSLEVGDNDLVYISHRAFS 174 Query: 134 LLV----LKLNRNRISAIPPK-MFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 188 L+ L L + ++A+P + + L L L L I N+ F+ L LK L++ Sbjct: 175 GLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDY 234 Query: 189 NGVTKLMD-GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAW 247 + +M + +GL N+ L + + NL+ + L+ L L+LS N I+ I + Sbjct: 235 WPLLDMMPANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMF 293 Query: 248 EFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLK 307 +L EL + L ++ SF GL L L++ N + + + F +L+ L + Sbjct: 294 SDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSIN 353 Query: 308 NNEIS 312 NN ++ Sbjct: 354 NNPLA 358 Score = 51.6 bits (122), Expect = 4e-06 Identities = 57/235 (24%), Positives = 107/235 (45%), Gaps = 13/235 (5%) Query: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITL--LSLAG 70 L ++++ D+S N++ + L +L+ +++ +N+L I + S ++L L+L Sbjct: 128 LSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRA-FSGLLSLEQLTLEK 186 Query: 71 NRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPG--- 125 + + E L +SL +L L NI+ + AF L LK+L ++ + M P Sbjct: 187 CNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSL 246 Query: 126 YFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSL 184 Y NL + L + +S +P FK L L HL L+ N I ++ F L L+ L Sbjct: 247 YGLNLTS----LSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQEL 302 Query: 185 KMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAI 239 + + + +F GL + +L + N L + + L+ L ++ N + Sbjct: 303 HIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357 Score = 42.0 bits (97), Expect = 0.003 Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 1/82 (1%) Query: 552 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611 L + G +LEC+A G P P I+W R V+ D I + +D Sbjct: 420 LLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLG-DGTLEIRFAQDQDS 478 Query: 612 GVYSCTAQNSAGSISANATLTV 633 G+Y C A N+AG+ + A+LTV Sbjct: 479 GMYVCIASNAAGNDTFTASLTV 500 Score = 41.2 bits (95), Expect = 0.005 Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 2/79 (2%) Query: 648 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAA--GNQLLIIVDSDVSDAGKY 705 V +G+T L+C A G P P ++W + T+ + A G+ L I + D+G Y Sbjct: 422 VDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMY 481 Query: 706 TCEMSNTLGTERGNVRLSV 724 C SN G + L+V Sbjct: 482 VCIASNAAGNDTFTASLTV 500 >gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo sapiens] Length = 592 Score = 149 bits (375), Expect = 2e-35 Identities = 148/514 (28%), Positives = 234/514 (45%), Gaps = 47/514 (9%) Query: 41 REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 100 R V L +P+ + A LL L+ NRI + P L +LE LDLS N I+ + Sbjct: 36 RAVACTRRRLTAVPD--GIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHV 93 Query: 101 QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQH 159 EPG F NL L VL+L N++ IPP +F +L L Sbjct: 94 ----------------------EPGAFANLPR-LRVLRLRGNQLKLIPPGVFTRLDNLTL 130 Query: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219 L+L+ NK+ + TFQ L +L+ L++ N + + AF GL +E L L+ NLT ++ Sbjct: 131 LDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALS 190 Query: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLN 278 L L L L L AI + + L L++ + L + S GL+L Sbjct: 191 GESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNL-T 249 Query: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338 +L + + ++ + A R + L L+L +N IS G+F L +LR L L G + Sbjct: 250 SLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTV---PRGSFRDLVRLRELHLAGALL 306 Query: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398 + +AF GL + L+LS+N + +L+ + F + L+ L ++ + L CDC+L W+ Q Sbjct: 307 AVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQR 366 Query: 399 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDF--PKPQITVQP-ETQSAIKGSN 455 NF + A CA P ++G ++ + PD + + F KP+I + + +A G + Sbjct: 367 RKTLNFDGRLPA-CATPAEVRGDALRNL-PDSVLFEYFVCRKPKIRERRLQRVTATAGED 424 Query: 456 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515 + F+C A + T AW A A + G L +++ Sbjct: 425 VRFLCRA--EGEPAPTVAWVTPQHRPVTATSAGRARVLPGG--------TLEIQDARPQD 474 Query: 516 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP 549 G Y CV SN G + + A LTV P+ +TP Sbjct: 475 SGTYTCVASN-AGGNDTYFATLTVRPEPAANRTP 507 Score = 98.6 bits (244), Expect = 3e-20 Identities = 79/279 (28%), Positives = 150/279 (53%), Gaps = 9/279 (3%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILP 78 DLS N ++ ++ + ++L LR ++L N+L+ I P + N+TLL L+ N++V +L Sbjct: 84 DLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLD 143 Query: 79 EHLKEFQSLETLDLSSNNISEL-QTAFPA-LQLKYLYLNSNRVTSMEPGYFDNLANTLLV 136 ++ SL L++ N++ + + AF L L+ L L +T++ +L +L Sbjct: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHL-RSLGA 202 Query: 137 LKLNRNRISAIPPKMF-KLPQLQHLEL-NRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 194 L+L I+++ + F +LP L HLE+ N ++ V + +GL L SL + +T + Sbjct: 203 LRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-LTSLSVTHTNITAV 261 Query: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLS 254 A +++ L L HN ++ + +G L+ L+ELHL+ + + P A+ +++ Sbjct: 262 PAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIR 321 Query: 255 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC 293 L+L+ N LS L++S+F ++ L TL + N ++ DC Sbjct: 322 LLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA--CDC 358 Score = 52.4 bits (124), Expect = 2e-06 Identities = 31/87 (35%), Positives = 41/87 (47%), Gaps = 1/87 (1%) Query: 552 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611 +T AG R C A G PAP +AW A R V+P I D + +D Sbjct: 417 VTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLP-GGTLEIQDARPQDS 475 Query: 612 GVYSCTAQNSAGSISANATLTVLETPS 638 G Y+C A N+ G+ + ATLTV P+ Sbjct: 476 GTYTCVASNAGGNDTYFATLTVRPEPA 502 Score = 40.0 bits (92), Expect = 0.012 Identities = 30/88 (34%), Positives = 37/88 (42%), Gaps = 4/88 (4%) Query: 647 TVTKGETAVLQCIAGGSPPPKLNW-TKDDSPLVVTE--RHFFAAGNQLLIIVDSDVSDAG 703 T T GE C A G P P + W T P+ T R G L I D+ D+G Sbjct: 418 TATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEI-QDARPQDSG 476 Query: 704 KYTCEMSNTLGTERGNVRLSVIPTPTCD 731 YTC SN G + L+V P P + Sbjct: 477 TYTCVASNAGGNDTYFATLTVRPEPAAN 504 Score = 32.3 bits (72), Expect = 2.4 Identities = 24/85 (28%), Positives = 39/85 (45%), Gaps = 1/85 (1%) Query: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRI 73 H++ +LSHN +S + S L LRE+ L L + P I LL+L+ N + Sbjct: 271 HLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLL 330 Query: 74 VEILPEHLKEFQSLETLDLSSNNIS 98 + +LETL + N ++ Sbjct: 331 STLEESTFHSVNTLETLRVDGNPLA 355 >gi|198041768 synleurin [Homo sapiens] Length = 622 Score = 147 bits (370), Expect = 7e-35 Identities = 124/397 (31%), Positives = 190/397 (47%), Gaps = 38/397 (9%) Query: 32 SSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLD 91 SS+ L + R++ N L +IP P S L L GN I I L SL L Sbjct: 33 SSVCQLCTGRQINCRNLGLSSIPKNFPEST--VFLYLTGNNISYINESELTGLHSLVALY 90 Query: 92 LSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPP 149 L ++NI + AF L+ L +L+LN+N + ++PG F L N L L L N++S +P Sbjct: 91 LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLN-LRNLYLQYNQVSFVPR 149 Query: 150 KMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEIL 208 +F L +Q+L L RN++ + TF G+ AL+ L + N + ++ + F L N+ L Sbjct: 150 GVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACL 209 Query: 209 QLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDD 268 L NNLT++ L L+ L LS N I I P A Sbjct: 210 YLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFA---------------------- 247 Query: 269 SSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNG-AFSGLDK 327 F GL+ L L + N+R+ + F G+++LK L L +N+ +E++N FS L Sbjct: 248 --FKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHND----LENLNSDTFSLLKN 301 Query: 328 LRRLILQGNRIRSITKKAFTGLDA-LEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386 L L L NRI SI F + A L+ L+LS N + +L + L L N++ Sbjct: 302 LIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPW 361 Query: 387 LCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 423 C+C+L L W+A + +N C +P ++GR++ Sbjct: 362 ECNCKLLGLRDWLASSAIT--LNIYCQNPPSMRGRAL 396 Score = 72.0 bits (175), Expect = 3e-12 Identities = 61/199 (30%), Positives = 101/199 (50%), Gaps = 6/199 (3%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG-PVSANITLLSLAGNRIVEILP 78 +L NRL+ + + + + +LR + L+NN + I G N+ L L N + ++ Sbjct: 162 NLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPS 221 Query: 79 EHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLV 136 + +SL L LS N I +Q AF L L+YL L ++R+ ++ F + N L Sbjct: 222 NAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGI-NNLKH 280 Query: 137 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGA-LKSLKMQRNGVTKL 194 L L+ N + + F L L +L+L+RN+I ++D TF+ +GA LK L + N +T L Sbjct: 281 LILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTAL 340 Query: 195 MDGAFWGLSNMEILQLDHN 213 LS++ LQ + N Sbjct: 341 HPRVLKPLSSLIHLQANSN 359 >gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] Length = 620 Score = 145 bits (366), Expect = 2e-34 Identities = 141/466 (30%), Positives = 225/466 (48%), Gaps = 43/466 (9%) Query: 90 LDLSSNNISELQ----TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRIS 145 LDL N I L +FP L+ L LN N V+++EPG F+NL N L L L NR+ Sbjct: 76 LDLGKNRIKTLNQDEFASFP--HLEELELNENIVSAVEPGAFNNLFN-LRTLGLRSNRLK 132 Query: 146 AIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSN 204 IP +F L L L+++ NKI + FQ L LKSL++ N + + AF GL++ Sbjct: 133 LIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNS 192 Query: 205 MEILQLDHNNLTEITK---GWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT-F 260 +E L L+ NLT I L+GL++L+ HL+ NAI S ++ +L L+++ + Sbjct: 193 LEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYS---FKRLYRLKVLEISHW 249 Query: 261 NHLSRLDDSSFLGLSL--LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDM 318 +L + + GL+L L+ H V Y+A R L L+ L+L N IS TIE Sbjct: 250 PYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLA---VRHLVYLRFLNLSYNPIS-TIE-- 303 Query: 319 NGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 378 L +L+ + L G ++ + AF GL+ L L++S N + +L+ + F + L+ Sbjct: 304 GSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLET 363 Query: 379 LHLNTSSLLCDCQLKWL--PQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDF 436 L L+++ L CDC+L W+ +W N Q +CA P+ ++G+ F PD + + F Sbjct: 364 LILDSNPLACDCRLLWVFRRRWRLNFNRQ---QPTCATPEFVQGKE-FKDFPDVLLPNYF 419 Query: 437 PKPQITVQPETQSAI---KGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 493 + ++ + +G + F+C A D P W + L A+ + Sbjct: 420 TCRRARIRDRKAQQVFVDEGHTVQFVCRA--DGDPPPAILWLSPRKHLVSAKSNGRLTVF 477 Query: 494 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 539 G L +R + G Y C+ +N G + S+ A L V Sbjct: 478 PDG--------TLEVRYAQVQDNGTYLCIAAN-AGGNDSMPAHLHV 514 Score = 86.7 bits (213), Expect = 1e-16 Identities = 77/302 (25%), Positives = 149/302 (49%), Gaps = 29/302 (9%) Query: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNR 72 H+ +L+ N +S ++ + ++L +LR + L +N L+ IP LG + +N+T L ++ N+ Sbjct: 96 HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP-LGVFTGLSNLTKLDISENK 154 Query: 73 IVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNL 130 IV +L ++ +L++L++ N++ + AF L L+ L L +TS+ +L Sbjct: 155 IVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHL 214 Query: 131 ANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNG 190 + L+VL+L I+AI FK L R K+ + + Sbjct: 215 -HGLIVLRLRHLNINAIRDYSFK-------RLYRLKVLEISHWPY--------------- 251 Query: 191 VTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC 250 + + +GL N+ L + H NLT + + L+ L+ L+LS N I+ I Sbjct: 252 LDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHEL 310 Query: 251 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 310 +L E+ L L+ ++ +F GL+ L L++ N+++ + + F + +L+TL L +N Sbjct: 311 LRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNP 370 Query: 311 IS 312 ++ Sbjct: 371 LA 372 Score = 76.6 bits (187), Expect = 1e-13 Identities = 105/470 (22%), Positives = 176/470 (37%), Gaps = 73/470 (15%) Query: 207 ILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRL 266 +L L N + + + L+EL L++N ++ + P A+ L L L N L + Sbjct: 75 LLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLI 134 Query: 267 DDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLD 326 F GLS L L I N++ + D F+ L +LK+L++ +N++ + + AFSGL+ Sbjct: 135 PLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYI---SHRAFSGLN 191 Query: 327 KLRRLILQGNRIRSITKKAFT---GLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLH--- 380 L +L L+ + SI +A + GL L L+ NAI ++K L+ H Sbjct: 192 SLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPY 251 Query: 381 -----------LNTSSL-LCDCQLKWLPQWVAEN-----------NFQSFVNASCAHPQL 417 LN +SL + C L +P + N S + S H L Sbjct: 252 LDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELL 311 Query: 418 ------LKGRSIFAVSPDGF-------VCDDFPKPQITVQPETQSAIKGSNLSFICSAAS 464 L G + V P F V + T++ ++ + S Sbjct: 312 RLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371 Query: 465 SSDSPMTFAWKKDNELLHDAEMENYAHLR-AQGGEVMEYTTILRLREVEFASEGKYQCVI 523 + D + + +++ L + + A QG E ++ +L + Sbjct: 372 ACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVL----------------L 415 Query: 524 SNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTD 583 N+F T + + + G + C A G P P I W Sbjct: 416 PNYF----------TCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHL 465 Query: 584 FPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 633 A R+ V P D + +++D G Y C A N+ G+ S A L V Sbjct: 466 VSAKSNGRLTVFP-DGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 514 Score = 49.3 bits (116), Expect = 2e-05 Identities = 58/230 (25%), Positives = 101/230 (43%), Gaps = 27/230 (11%) Query: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSAN-ITLLSLAGN 71 L ++++ D+S N++ + L +L+ +++ +N+L I + N + L+L Sbjct: 142 LSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKC 201 Query: 72 RIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFD 128 + I E L L L L NI+ ++ +F L +LK L ++ + +M P Sbjct: 202 NLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLY 261 Query: 129 NLANT----------------------LLVLKLNRNRISAIPPKMF-KLPQLQHLELNRN 165 L T L L L+ N IS I M +L +LQ ++L Sbjct: 262 GLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGG 321 Query: 166 KIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNL 215 ++ V+ F+GL L+ L + N +T L + F + N+E L LD N L Sbjct: 322 QLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371 Score = 36.2 bits (82), Expect = 0.17 Identities = 18/58 (31%), Positives = 34/58 (58%) Query: 329 RRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386 R L L NRI+++ + F LE L+L++N + +++ AF+ + L+ L L ++ L Sbjct: 74 RLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL 131 Score = 32.3 bits (72), Expect = 2.4 Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 6/81 (7%) Query: 648 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH----FFAAGNQLLIIVDSDVSDAG 703 V +G T C A G PPP + W LV + + F G L + + V D G Sbjct: 436 VDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGT--LEVRYAQVQDNG 493 Query: 704 KYTCEMSNTLGTERGNVRLSV 724 Y C +N G + L V Sbjct: 494 TYLCIAANAGGNDSMPAHLHV 514 >gi|225579152 insulin-like growth factor binding protein, acid labile subunit isoform 1 precursor [Homo sapiens] Length = 643 Score = 141 bits (355), Expect = 4e-33 Identities = 126/442 (28%), Positives = 201/442 (45%), Gaps = 54/442 (12%) Query: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-------------NLG-------PVS 60 L N+L + + +H +L + L+NN L + NLG P + Sbjct: 167 LERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA 226 Query: 61 A-----NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAFPAL-QLKYLY 113 A ++ L LAGNR+ + P L LDLS N + ++ F L +L+ LY Sbjct: 227 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 286 Query: 114 LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDG 172 L+ N + ++ PG F L L L L+ NR++ + F L L+ L L+ N I ++ Sbjct: 287 LDRNLIAAVAPGAFLGL-KALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRP 345 Query: 173 LTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQEL 232 TF+ L L+ L++ N + +L + +F GL +E+L LDHN L E+ G GL + + Sbjct: 346 RTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVM 405 Query: 233 HLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIAD 292 +LS N + + + KL L L + L R+ +F GLS L L + +N + I + Sbjct: 406 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 465 Query: 293 CAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDAL 352 + GL+ L LDL +N+++ + F GL KL L+L NR+ + A L Sbjct: 466 QSLWGLAELLELDLTSNQLTHLPHRL---FQGLGKLEYLLLSRNRLAELPADALGPLQRA 522 Query: 353 EHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLL--------------------CDCQL 392 LD+S N + +L + + + +L+ L L +SL C C L Sbjct: 523 FWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPL 582 Query: 393 KWLPQWVAEN--NFQSFVNASC 412 K L + +N FV A C Sbjct: 583 KALRDFALQNPSAVPRFVQAIC 604 Score = 134 bits (337), Expect = 5e-31 Identities = 97/295 (32%), Positives = 155/295 (52%), Gaps = 6/295 (2%) Query: 93 SSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK-M 151 SS N++ L P + L+L+ N ++S+ P F NL++ L L L ++ ++ P+ + Sbjct: 99 SSRNLTRLPDGVPG-GTQALWLDGNNLSSVPPAAFQNLSS-LGFLNLQGGQLGSLEPQAL 156 Query: 152 FKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 211 L L HL L RN+++++ TF AL SL + N +++L DG F GL ++ L L Sbjct: 157 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 216 Query: 212 HNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF 271 N+L + GL L+EL L+ N + + P + +L ELDL+ N L + + F Sbjct: 217 WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVF 276 Query: 272 LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRL 331 + L L L++ N ++ +A AF GL +L+ LDL +N ++ +ED F GL LR L Sbjct: 277 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVL 333 Query: 332 ILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386 L N I S+ + F L LE L L N I L +F + +L+ L L+ + L Sbjct: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL 388 Score = 97.1 bits (240), Expect = 8e-20 Identities = 79/269 (29%), Positives = 127/269 (47%), Gaps = 27/269 (10%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79 DLSHNR++ + + L LR +L L+ N I + P Sbjct: 310 DLSHNRVAGLLEDTFPGLLGLR-----------------------VLRLSHNAIASLRPR 346 Query: 80 HLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137 K+ LE L L N I +L + +F L QL+ L L+ N++ ++ G F L N + V+ Sbjct: 347 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN-VAVM 405 Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196 L+ N + +P ++F+ L +L L L + + + TF GL L+ L ++ NG+ + + Sbjct: 406 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 465 Query: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256 + WGL+ + L L N LT + GL L+ L LS+N + + DA Q+ L Sbjct: 466 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 525 Query: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNN 285 D++ N L L +S L L L + NN Sbjct: 526 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 554 Score = 58.9 bits (141), Expect = 2e-08 Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 31/237 (13%) Query: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN---LGPVSANITLLSLA 69 L + L HNR+ + S L L + L++N+L+ + LG N+ +++L+ Sbjct: 351 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG--LTNVAVMNLS 408 Query: 70 GNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYF 127 GN + + + + L +L L + + ++ F L L+ L+L N + +E Sbjct: 409 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE---- 464 Query: 128 DNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 187 ++ L +L L+L N++ ++ FQGLG L+ L + Sbjct: 465 --------------------EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLS 504 Query: 188 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 244 RN + +L A L L + HN L + L L L+ L L N++ +P Sbjct: 505 RNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 561 Score = 32.0 bits (71), Expect = 3.2 Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGN 71 D+SHNRL + S ++ L LR + L NN L T P + L L GN Sbjct: 526 DVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT---PQPPGLERLWLEGN 574 >gi|4826772 insulin-like growth factor binding protein, acid labile subunit isoform 2 precursor [Homo sapiens] Length = 605 Score = 141 bits (355), Expect = 4e-33 Identities = 126/442 (28%), Positives = 201/442 (45%), Gaps = 54/442 (12%) Query: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-------------NLG-------PVS 60 L N+L + + +H +L + L+NN L + NLG P + Sbjct: 129 LERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA 188 Query: 61 A-----NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAFPAL-QLKYLY 113 A ++ L LAGNR+ + P L LDLS N + ++ F L +L+ LY Sbjct: 189 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 248 Query: 114 LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDG 172 L+ N + ++ PG F L L L L+ NR++ + F L L+ L L+ N I ++ Sbjct: 249 LDRNLIAAVAPGAFLGL-KALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRP 307 Query: 173 LTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQEL 232 TF+ L L+ L++ N + +L + +F GL +E+L LDHN L E+ G GL + + Sbjct: 308 RTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVM 367 Query: 233 HLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIAD 292 +LS N + + + KL L L + L R+ +F GLS L L + +N + I + Sbjct: 368 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 427 Query: 293 CAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDAL 352 + GL+ L LDL +N+++ + F GL KL L+L NR+ + A L Sbjct: 428 QSLWGLAELLELDLTSNQLTHLPHRL---FQGLGKLEYLLLSRNRLAELPADALGPLQRA 484 Query: 353 EHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLL--------------------CDCQL 392 LD+S N + +L + + + +L+ L L +SL C C L Sbjct: 485 FWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPL 544 Query: 393 KWLPQWVAEN--NFQSFVNASC 412 K L + +N FV A C Sbjct: 545 KALRDFALQNPSAVPRFVQAIC 566 Score = 134 bits (337), Expect = 5e-31 Identities = 97/295 (32%), Positives = 155/295 (52%), Gaps = 6/295 (2%) Query: 93 SSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK-M 151 SS N++ L P + L+L+ N ++S+ P F NL++ L L L ++ ++ P+ + Sbjct: 61 SSRNLTRLPDGVPG-GTQALWLDGNNLSSVPPAAFQNLSS-LGFLNLQGGQLGSLEPQAL 118 Query: 152 FKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 211 L L HL L RN+++++ TF AL SL + N +++L DG F GL ++ L L Sbjct: 119 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 178 Query: 212 HNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF 271 N+L + GL L+EL L+ N + + P + +L ELDL+ N L + + F Sbjct: 179 WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVF 238 Query: 272 LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRL 331 + L L L++ N ++ +A AF GL +L+ LDL +N ++ +ED F GL LR L Sbjct: 239 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVL 295 Query: 332 ILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386 L N I S+ + F L LE L L N I L +F + +L+ L L+ + L Sbjct: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL 350 Score = 97.1 bits (240), Expect = 8e-20 Identities = 79/269 (29%), Positives = 127/269 (47%), Gaps = 27/269 (10%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79 DLSHNR++ + + L LR +L L+ N I + P Sbjct: 272 DLSHNRVAGLLEDTFPGLLGLR-----------------------VLRLSHNAIASLRPR 308 Query: 80 HLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137 K+ LE L L N I +L + +F L QL+ L L+ N++ ++ G F L N + V+ Sbjct: 309 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN-VAVM 367 Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196 L+ N + +P ++F+ L +L L L + + + TF GL L+ L ++ NG+ + + Sbjct: 368 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 427 Query: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256 + WGL+ + L L N LT + GL L+ L LS+N + + DA Q+ L Sbjct: 428 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 487 Query: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNN 285 D++ N L L +S L L L + NN Sbjct: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 516 Score = 58.9 bits (141), Expect = 2e-08 Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 31/237 (13%) Query: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN---LGPVSANITLLSLA 69 L + L HNR+ + S L L + L++N+L+ + LG N+ +++L+ Sbjct: 313 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG--LTNVAVMNLS 370 Query: 70 GNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYF 127 GN + + + + L +L L + + ++ F L L+ L+L N + +E Sbjct: 371 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE---- 426 Query: 128 DNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 187 ++ L +L L+L N++ ++ FQGLG L+ L + Sbjct: 427 --------------------EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLS 466 Query: 188 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 244 RN + +L A L L + HN L + L L L+ L L N++ +P Sbjct: 467 RNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523 Score = 32.0 bits (71), Expect = 3.2 Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGN 71 D+SHNRL + S ++ L LR + L NN L T P + L L GN Sbjct: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT---PQPPGLERLWLEGN 536 >gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] Length = 545 Score = 135 bits (339), Expect = 3e-31 Identities = 108/376 (28%), Positives = 180/376 (47%), Gaps = 8/376 (2%) Query: 62 NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRV 119 N+T + ++ + P+ LE L+++ ++ L T F L L L LN N + Sbjct: 74 NLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNML 133 Query: 120 TSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGL 178 ++ G F +LA L L L N++ A+P ++F+ L L+ L L +N + + F L Sbjct: 134 EALPEGLFQHLA-ALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192 Query: 179 GALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNA 238 +L++LK+ N ++ L G F L +++ L LD NN++E+ L L+ L L +NA Sbjct: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA 252 Query: 239 INRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGL 298 I + + L+ L L +N L L F L L + +N++ +A+ F L Sbjct: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312 Query: 299 SSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLS 358 S+L++L L N I+ G F L++L +L L N + ++ F L LE L LS Sbjct: 313 SNLRSLMLSYNAITHLPA---GIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLS 369 Query: 359 DNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSF-VNASCAHPQL 417 N + +L F L L L+ + CDC L +L W+ + + + CA P Sbjct: 370 KNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAY 429 Query: 418 LKGRSIFAVSPDGFVC 433 LKG+ + A++ VC Sbjct: 430 LKGQVVPALNEKQLVC 445 Score = 103 bits (257), Expect = 9e-22 Identities = 95/297 (31%), Positives = 149/297 (50%), Gaps = 9/297 (3%) Query: 20 DLSHNRLSFIKASS--MSHLQSLREVKLNNNELETIPN-LGPVSANITLLSLAGNRIVEI 76 DL SF+ S+ S+L SL ++ LN N LE +P L A + L L GN++ + Sbjct: 101 DLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQL-QA 159 Query: 77 LPEHL-KEFQSLETLDLSSNNISEL--QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANT 133 LP L + L+TL+L+ N +++L + P L+ L L++N ++ + G F L + Sbjct: 160 LPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGS- 218 Query: 134 LLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVT 192 L L L+ N IS +PP++F +L L+ L L RN I ++ F LG L L +Q N + Sbjct: 219 LQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLR 278 Query: 193 KLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQK 252 L G F + L L HN L + +G L L+ L LS NAI + + ++ Sbjct: 279 VLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEE 338 Query: 253 LSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309 L +L L N+L+ L + F LS L L + N+++ + + F +L L L N Sbjct: 339 LVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395 Score = 97.8 bits (242), Expect = 5e-20 Identities = 82/277 (29%), Positives = 130/277 (46%), Gaps = 6/277 (2%) Query: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGN 71 L + + L+ N L + HL +L + L N+L+ +P L ++ L+LA N Sbjct: 120 LTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN 179 Query: 72 RIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDN 129 + ++ E SL+TL LS+N +S L Q F L L+ L+L+SN ++ + P F Sbjct: 180 LLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQ 239 Query: 130 LANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 188 L L L L RN I+ +P +F L L L L N ++ + F L L + Sbjct: 240 LF-CLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTH 298 Query: 189 NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWE 248 N + + +G F LSN+ L L +N +T + G L L +L+L N + + P ++ Sbjct: 299 NQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQ 358 Query: 249 FCQKLSELDLTFNHLSRLDDSSF-LGLSLLNTLHIGN 284 KL L L+ N L+ L + F +L N GN Sbjct: 359 NLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395 Score = 71.6 bits (174), Expect = 4e-12 Identities = 54/205 (26%), Positives = 96/205 (46%), Gaps = 3/205 (1%) Query: 182 KSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINR 241 K++ T L AF N+ + + L + GL L++L ++ ++ Sbjct: 52 KNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLN 111 Query: 242 ISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSL 301 +S + + L +L L FN L L + F L+ L +LH+ N++ + F+ L+ L Sbjct: 112 LSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHL 171 Query: 302 KTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNA 361 KTL+L N ++ E++ F L L+ L L N + + + F L +L+ L L N Sbjct: 172 KTLNLAQNLLAQLPEEL---FHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNN 228 Query: 362 IMSLQGNAFSQMKKLQQLHLNTSSL 386 I L FSQ+ L++L L +++ Sbjct: 229 ISELPPQVFSQLFCLERLWLQRNAI 253 >gi|122937309 leucine rich repeat containing 4B [Homo sapiens] Length = 713 Score = 133 bits (335), Expect = 8e-31 Identities = 107/378 (28%), Positives = 171/378 (45%), Gaps = 35/378 (9%) Query: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 243 L +Q NG+ + F L ++EILQL N + +I G GL L L L N + + Sbjct: 91 LNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVP 150 Query: 244 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGN-NRVSYIADCAFRGLSSLK 302 A+E+ KL EL L N + + +F + L L +G R+ YI++ AF GL +L+ Sbjct: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLR 210 Query: 303 TL--------DLKNNEISWTIEDMN-----------GAFSGLDKLRRLILQGNRIRSITK 343 L D+ N +E++ G+F GL LR+L L ++ +I + Sbjct: 211 YLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIER 270 Query: 344 KAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN- 402 AF L +LE L+LS N +MSL + F+ + +L+++HLN + C+C + WL W+ E Sbjct: 271 NAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETV 330 Query: 403 NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSA 462 + A C P LKGR I + F C P I P + +G C Sbjct: 331 PSNTTCCARCHAPAGLKGRYIGELDQSHFTC---YAPVIVEPPTDLNVTEGMAAELKCRT 387 Query: 463 ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 522 +S S N L + + + R + + + T L V G+Y C+ Sbjct: 388 GTSMTSV--------NWLTPNGTLMTHGSYRVRISVLHDGT--LNFTNVTVQDTGQYTCM 437 Query: 523 ISNHFGSSYSVKAKLTVN 540 ++N G++ + A L V+ Sbjct: 438 VTNSAGNT-TASATLNVS 454 Score = 67.4 bits (163), Expect = 7e-11 Identities = 61/223 (27%), Positives = 105/223 (47%), Gaps = 8/223 (3%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRIVEIL 77 +L N + I+ + HL+ L ++L+ N + I +G + ++ L L NR+ + Sbjct: 92 NLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKI-EVGAFNGLPSLNTLELFDNRLTTVP 150 Query: 78 PEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFDNLANTL 134 + + L L L +N I + + AF + L+ L L R+ + F+ L N L Sbjct: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN-L 209 Query: 135 LVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 194 L L + IP + L +L+ LEL+ N++ + +FQGL +L+ L + V + Sbjct: 210 RYLNLGMCNLKDIP-NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATI 268 Query: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQN 237 AF L ++E L L HNNL + L L+ +HL+ N Sbjct: 269 ERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311 Score = 48.1 bits (113), Expect = 4e-05 Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 1/91 (1%) Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 602 P + P DL + G A L+C G + W GT R + D Sbjct: 364 PVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422 Query: 603 IVDVKIEDIGVYSCTAQNSAGSISANATLTV 633 +V ++D G Y+C NSAG+ +A+ATL V Sbjct: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453 Score = 37.4 bits (85), Expect = 0.075 Identities = 25/91 (27%), Positives = 40/91 (43%), Gaps = 4/91 (4%) Query: 637 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH---FFAAGNQLLI 693 P + P D VT+G A L+C G S +NW + L+ + + L Sbjct: 364 PVIVEPPTDLNVTEGMAAELKCRTGTSMT-SVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422 Query: 694 IVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724 + V D G+YTC ++N+ G + L+V Sbjct: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453 Score = 33.5 bits (75), Expect = 1.1 Identities = 30/111 (27%), Positives = 47/111 (42%), Gaps = 25/111 (22%) Query: 9 SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSL 68 +L L + +LS NRL I+ S L SLR++ L + ++ TI Sbjct: 224 NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIER------------- 270 Query: 69 AGNRIVEILPEHLKEFQSLETLDLSSNNISEL--QTAFPALQLKYLYLNSN 117 + +SLE L+LS NN+ L P +L+ ++LN N Sbjct: 271 ----------NAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311 >gi|76880480 hypothetical protein LOC9865 [Homo sapiens] Length = 811 Score = 131 bits (330), Expect = 3e-30 Identities = 115/396 (29%), Positives = 185/396 (46%), Gaps = 20/396 (5%) Query: 68 LAGNRIVEILPE--HLKEFQSLETLDLSSNNISELQTAFPAL---QLKYLYLNSNRVTSM 122 L NR + ++P+ L + T L N I+ + TAF QL+ L L N++ S+ Sbjct: 40 LCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNI-TAFDFHRLGQLRRLDLQYNQIRSL 98 Query: 123 EPGYFDNLANTLLVLKLNRNRISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGAL 181 P F+ L+ L L L N + A+ P + L +L+ L N N+I + +F+GL +L Sbjct: 99 HPKTFEKLSR-LEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESL 157 Query: 182 KSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINR 241 L++ N + L D F L N+ L L+ N + + K L L+ L+LS N + Sbjct: 158 VKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQP 217 Query: 242 ISPDAWEFC--QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLS 299 A F + LS L L+ N+L L F L L L + N+++++A AF GL Sbjct: 218 SLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLE 277 Query: 300 SLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSD 359 +L+ L L+ N +S + L L L L GN + ++ F L L L L + Sbjct: 278 ALRELRLEGNRLS---QLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRN 334 Query: 360 NAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQS---FVNASCAHPQ 416 NA+ +L G+ F+ L +L L+ + CDC+L+ L +W+ + + Q V C HP Sbjct: 335 NALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPP 394 Query: 417 LLKGRSIFAVS----PDGFVCDDFPKPQITVQPETQ 448 L+G+ + + +G D P +T Q Sbjct: 395 ALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQ 430 Score = 94.7 bits (234), Expect = 4e-19 Identities = 89/313 (28%), Positives = 132/313 (42%), Gaps = 29/313 (9%) Query: 8 FSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP--NLGPVSANITL 65 F L + R DL +N++ + + L L E+ L NN L+ + L P+ + + Sbjct: 77 FDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLR-KLRI 135 Query: 66 LSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSME 123 L GN I + + +SL L L N + L A P L YL+L SNR+ + Sbjct: 136 LYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLG 195 Query: 124 PGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKS 183 F L L L L+ N + P L+H TF L +L S Sbjct: 196 KNAFAQLGK-LRFLNLSANELQ---------PSLRH------------AATFAPLRSLSS 233 Query: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 243 L + N + L F L + +L L N LT + +GL L+EL L N ++++ Sbjct: 234 LILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLP 293 Query: 244 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 303 E L LDL+ N LS L ++F L L L + NN +S ++ F +L Sbjct: 294 TALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYR 353 Query: 304 LDLKNNEISWTIE 316 LDL N WT + Sbjct: 354 LDLDGN--GWTCD 364 >gi|51317373 netrin-G1 ligand [Homo sapiens] Length = 640 Score = 126 bits (317), Expect = 9e-29 Identities = 121/428 (28%), Positives = 191/428 (44%), Gaps = 33/428 (7%) Query: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219 L L+ N+I+ + +F+ L L+ L++ RN + + GAF GL+N+ L+L N LT I Sbjct: 81 LNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIP 140 Query: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLN 278 G L L+EL L N I I A+ L LDL LS + + +F GLS L Sbjct: 141 NGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLR 200 Query: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338 L++ + I + L L LDL N +S G+F GL L++L + ++I Sbjct: 201 YLNLAMCNLREIPN--LTPLIKLDELDLSGNHLS---AIRPGSFQGLMHLQKLWMIQSQI 255 Query: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398 + I + AF L +L ++L+ N + L + F+ + L+++HL+ + C+C + WL W Sbjct: 256 QVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWW 315 Query: 399 VAE-NNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLS 457 + + + A C P LKGR I + + F C P I P + +G Sbjct: 316 IKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC---YAPVIVEPPADLNVTEGMAAE 372 Query: 458 FICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEG 517 C A++S S +++ + H A A L L V G Sbjct: 373 LKCRASTSLTS-VSWITPNGTVMTHGAYKVRIAVLS---------DGTLNFTNVTVQDTG 422 Query: 518 KYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDL--TIRAGAM------ARLECAAVGH 569 Y C++SN G++ A T+N+ + T TP T+ M AR VG Sbjct: 423 MYTCMVSNSVGNT---TASATLNVTAA-TTTPFSYFSTVTVETMEPSQDEARTTDNNVG- 477 Query: 570 PAPQIAWQ 577 P P + W+ Sbjct: 478 PTPVVDWE 485 Score = 87.8 bits (216), Expect = 5e-17 Identities = 78/271 (28%), Positives = 130/271 (47%), Gaps = 36/271 (13%) Query: 59 VSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNR 118 +S N LL+L N+I I K + LE L LS N+I Sbjct: 74 ISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHI--------------------- 112 Query: 119 VTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQG 177 ++E G F+ LAN L L+L NR++ IP F L +L+ L L N I+++ F Sbjct: 113 -RTIEIGAFNGLAN-LNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNR 170 Query: 178 LGALKSLKM-QRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQ 236 + +L+ L + + ++ + +GAF GLSN+ L L NL EI L L+ L EL LS Sbjct: 171 IPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSG 228 Query: 237 NAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFR 296 N ++ I P +++ L +L + + + ++ ++F L L +++ +N ++ + F Sbjct: 229 NHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFT 288 Query: 297 GLSSLKTLDLKNNE---------ISWTIEDM 318 L L+ + L +N +SW I+DM Sbjct: 289 PLHHLERIHLHHNPWNCNCDILWLSWWIKDM 319 Score = 72.8 bits (177), Expect = 2e-12 Identities = 67/226 (29%), Positives = 110/226 (48%), Gaps = 8/226 (3%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEIL 77 +L N++ IK +S HL+ L ++L+ N + TI +G + AN+ L L NR+ I Sbjct: 82 NLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTI-EIGAFNGLANLNTLELFDNRLTTIP 140 Query: 78 PEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFDNLANTL 134 L+ L L +N I + + AF + L+ L L R++ + G F+ L+N L Sbjct: 141 NGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSN-L 199 Query: 135 LVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 194 L L + IP + L +L L+L+ N + + +FQGL L+ L M ++ + + Sbjct: 200 RYLNLAMCNLREIP-NLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVI 258 Query: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 240 AF L ++ + L HNNLT + L L+ +HL N N Sbjct: 259 ERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWN 304 Score = 59.3 bits (142), Expect = 2e-08 Identities = 51/205 (24%), Positives = 92/205 (44%), Gaps = 30/205 (14%) Query: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----NLGPVSANITLLSL 68 L +++ +L NRL+ I + +L L+E+ L NN +E+IP N P + L L Sbjct: 123 LANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGEL 182 Query: 69 AGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFD 128 R+ I + +L L+L+ N+ E+ P ++L L L+ N ++++ PG F Sbjct: 183 --KRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQ 240 Query: 129 NLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 188 L + LQ L + +++I+ ++ F L +L + + Sbjct: 241 GLMH------------------------LQKLWMIQSQIQVIERNAFDNLQSLVEINLAH 276 Query: 189 NGVTKLMDGAFWGLSNMEILQLDHN 213 N +T L F L ++E + L HN Sbjct: 277 NNLTLLPHDLFTPLHHLERIHLHHN 301 Score = 48.9 bits (115), Expect = 3e-05 Identities = 33/132 (25%), Positives = 54/132 (40%), Gaps = 5/132 (3%) Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 602 P + P DL + G A L+C A ++W GT + + D Sbjct: 354 PVIVEPPADLNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412 Query: 603 IVDVKIEDIGVYSCTAQNSAGSISANATLTV---LETP-SFLRPLLDRTVTKGETAVLQC 658 +V ++D G+Y+C NS G+ +A+ATL V TP S+ + T+ + Sbjct: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTT 472 Query: 659 IAGGSPPPKLNW 670 P P ++W Sbjct: 473 DNNVGPTPVVDW 484 Score = 35.8 bits (81), Expect = 0.22 Identities = 25/96 (26%), Positives = 41/96 (42%), Gaps = 4/96 (4%) Query: 637 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH---FFAAGNQLLI 693 P + P D VT+G A L+C A S ++W + ++ + + L Sbjct: 354 PVIVEPPADLNVTEGMAAELKCRASTSLT-SVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412 Query: 694 IVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 + V D G YTC +SN++G + L+V T Sbjct: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATT 448 >gi|62912470 leucine-rich repeat-containing G protein-coupled receptor 6 isoform 1 [Homo sapiens] Length = 967 Score = 125 bits (315), Expect = 2e-28 Identities = 84/263 (31%), Positives = 134/263 (50%), Gaps = 8/263 (3%) Query: 121 SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLG 179 S PG D L L L+ N ++ + P +F L L+ L L+ N + ++ G F GL Sbjct: 58 SAVPGDLDPLT---AYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLY 114 Query: 180 ALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAI 239 +LK L +Q N + + A W L +++ L+LD N ++ + + GL L+ L L NA+ Sbjct: 115 SLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 174 Query: 240 NRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLS 299 I A L + L N +S + D +F L+ L LH+ NNR+ ++ +F GL Sbjct: 175 TEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLH 234 Query: 300 SLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSD 359 +L+TLDL N+ +++ A L +L+ L N I++I +KAF G L+ + D Sbjct: 235 NLETLDLNYNK----LQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYD 290 Query: 360 NAIMSLQGNAFSQMKKLQQLHLN 382 N I + +AF + KL L LN Sbjct: 291 NPIQFVGRSAFQYLPKLHTLSLN 313 Score = 123 bits (308), Expect = 1e-27 Identities = 113/374 (30%), Positives = 184/374 (49%), Gaps = 18/374 (4%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIVEILP 78 DLS N L+ ++ HL+ L E++L+ N L IP ++ +L L N++ I Sbjct: 72 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 131 Query: 79 EHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLV 136 E L E SL++L L +N IS + + +F L L++L+L+ N +T + +NL L Sbjct: 132 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP-ALQA 190 Query: 137 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195 + L NRIS IP F+ L L L L+ N+I+++ +F+GL L++L + N + + Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF- 249 Query: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255 A L ++ L +NN+ I + G +LQ +H N I + A+++ KL Sbjct: 250 PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309 Query: 256 LDLTFNHLSRLDDSSF---LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS 312 L L +D F G + L L + + + + L L+ L+L +N+I Sbjct: 310 LSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI- 364 Query: 313 WTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQ 372 E++ + KL + LQ NRI I F+ L +L+ LDLS NAI S+ AFS Sbjct: 365 ---EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420 Query: 373 MKKLQQLHLNTSSL 386 + L +L L + L Sbjct: 421 LHSLVKLDLTDNQL 434 Score = 85.5 bits (210), Expect = 2e-16 Identities = 79/293 (26%), Positives = 137/293 (46%), Gaps = 12/293 (4%) Query: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 79 L N L+ I ++++L +L+ + L N + IP+ + ++ +L L NRI + Sbjct: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228 Query: 80 HLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL-VL 137 + +LETLDL+ N + E A L +L+ L ++N + ++ F + N LL + Sbjct: 229 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MGNPLLQTI 286 Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196 N I + F+ LP+L L LN + + +G +L+ L + R G+ L Sbjct: 287 HFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS 345 Query: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256 G L + +L+L HN + E+ L+ L+E+ L N I I D + L L Sbjct: 346 GMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 403 Query: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309 DL++N + + +F L L L + +N+++ + GL L L LK N Sbjct: 404 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 453 Score = 57.4 bits (137), Expect = 7e-08 Identities = 66/245 (26%), Positives = 109/245 (44%), Gaps = 32/245 (13%) Query: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NLGPVSANITLL---S 67 L +NR+ + S L +L + LN N+L+ P LG + NI + + Sbjct: 217 LHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKA 276 Query: 68 LAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAFPALQ----LKYLYL 114 GN +++ + + FQ L L LS N ++Q FP L+ L+ L L Sbjct: 277 FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-FPDLKGTTSLEILTL 335 Query: 115 NSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLT 174 + + G L L VL+L+ N+I +P + + +L+ + L N+I + T Sbjct: 336 TRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADT 393 Query: 175 FQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ---E 231 F L +L++L + N + + AF L ++ L L N LT + L GL+ L+ Sbjct: 394 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 453 Query: 232 LHLSQ 236 L LSQ Sbjct: 454 LALSQ 458 >gi|62912472 leucine-rich repeat-containing G protein-coupled receptor 6 isoform 2 [Homo sapiens] Length = 915 Score = 125 bits (313), Expect = 3e-28 Identities = 115/378 (30%), Positives = 186/378 (49%), Gaps = 18/378 (4%) Query: 16 ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIV 74 IS DLS N L+ ++ HL+ L E++L+ N L IP ++ +L L N++ Sbjct: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75 Query: 75 EILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLAN 132 I E L E SL++L L +N IS + + +F L L++L+L+ N +T + +NL Sbjct: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP- 134 Query: 133 TLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 191 L + L NRIS IP F+ L L L L+ N+I+++ +F+GL L++L + N + Sbjct: 135 ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 194 Query: 192 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 251 + A L ++ L +NN+ I + G +LQ +H N I + A+++ Sbjct: 195 QEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLP 253 Query: 252 KLSELDLTFNHLSRLDDSSF---LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKN 308 KL L L +D F G + L L + + + + L L+ L+L + Sbjct: 254 KLHTLSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 309 Query: 309 NEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN 368 N+I E++ + KL + LQ NRI I F+ L +L+ LDLS NAI S+ Sbjct: 310 NQI----EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364 Query: 369 AFSQMKKLQQLHLNTSSL 386 AFS + L +L L + L Sbjct: 365 AFSTLHSLVKLDLTDNQL 382 Score = 85.5 bits (210), Expect = 2e-16 Identities = 79/293 (26%), Positives = 137/293 (46%), Gaps = 12/293 (4%) Query: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 79 L N L+ I ++++L +L+ + L N + IP+ + ++ +L L NRI + Sbjct: 117 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 176 Query: 80 HLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL-VL 137 + +LETLDL+ N + E A L +L+ L ++N + ++ F + N LL + Sbjct: 177 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MGNPLLQTI 234 Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196 N I + F+ LP+L L LN + + +G +L+ L + R G+ L Sbjct: 235 HFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS 293 Query: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256 G L + +L+L HN + E+ L+ L+E+ L N I I D + L L Sbjct: 294 GMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 351 Query: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309 DL++N + + +F L L L + +N+++ + GL L L LK N Sbjct: 352 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 401 Score = 73.6 bits (179), Expect = 9e-13 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 3/160 (1%) Query: 227 LMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNR 286 +++ LS N + + P + + L EL L+ NHLS + +F GL L L + NN+ Sbjct: 14 IIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 73 Query: 287 VSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAF 346 + I A L SL++L L N IS E +F GL LR L L N + I +A Sbjct: 74 LGGIPAEALWELPSLQSLRLDANLISLVPE---RSFEGLSSLRHLWLDDNALTEIPVRAL 130 Query: 347 TGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386 L AL+ + L+ N I + AF + L LHL+ + + Sbjct: 131 NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRI 170 Score = 57.4 bits (137), Expect = 7e-08 Identities = 66/245 (26%), Positives = 109/245 (44%), Gaps = 32/245 (13%) Query: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NLGPVSANITLL---S 67 L +NR+ + S L +L + LN N+L+ P LG + NI + + Sbjct: 165 LHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKA 224 Query: 68 LAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAFPALQ----LKYLYL 114 GN +++ + + FQ L L LS N ++Q FP L+ L+ L L Sbjct: 225 FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-FPDLKGTTSLEILTL 283 Query: 115 NSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLT 174 + + G L L VL+L+ N+I +P + + +L+ + L N+I + T Sbjct: 284 TRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADT 341 Query: 175 FQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ---E 231 F L +L++L + N + + AF L ++ L L N LT + L GL+ L+ Sbjct: 342 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 401 Query: 232 LHLSQ 236 L LSQ Sbjct: 402 LALSQ 406 >gi|19743806 roundabout 1 isoform b [Homo sapiens] Length = 1612 Score = 124 bits (312), Expect = 4e-28 Identities = 81/252 (32%), Positives = 118/252 (46%), Gaps = 23/252 (9%) Query: 471 TFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSS 530 T +WKKD L D + + +GG++M + + GKY CV +N G Sbjct: 162 TISWKKDGSPLDDKD----ERITIRGGKLM-------ITYTRKSDAGKYVCVGTNMVGER 210 Query: 531 YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARER 590 S A+LTV PSF K P +L + A +C A G P P + W+KD G + P +R Sbjct: 211 ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR-- 267 Query: 591 RMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK 650 + + +D I V D+G Y+C A+N G A+ATLTV E P F+ D+ V Sbjct: 268 --YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL 325 Query: 651 GETAVLQCIAGGSPPPKLNWTKDDSPLVV-------TERHFFAAGNQLLIIVDSDVSDAG 703 G T QC A G+P P + W ++ S ++ + F + L I + SD G Sbjct: 326 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 385 Query: 704 KYTCEMSNTLGT 715 Y C+ N G+ Sbjct: 386 YYICQTLNVAGS 397 Score = 111 bits (278), Expect = 3e-24 Identities = 86/298 (28%), Positives = 124/298 (41%), Gaps = 13/298 (4%) Query: 434 DDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 493 +DFP P+I P KG + C A T W K E + + + +H Sbjct: 25 EDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 81 Query: 494 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML-PSFTKTPMDL 552 + + I+ R+ EG Y CV N+ G + S A L V +L F + P D+ Sbjct: 82 LLPSGSLFFLRIVHGRKSR-PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 140 Query: 553 TIRAGAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611 + G A +EC GHP P I+W+KDG ++ + I + D Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDA 196 Query: 612 GVYSCTAQNSAGSISAN-ATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNW 670 G Y C N G + A LTVLE PSF++ + VT ++A +C A G P P + W Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256 Query: 671 TKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 KDD L + + + L I D G YTC N +G + L+V P Sbjct: 257 RKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312 Score = 109 bits (272), Expect = 2e-23 Identities = 90/321 (28%), Positives = 131/321 (40%), Gaps = 35/321 (10%) Query: 438 KPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGG 497 +P +P + + F C A D T W+KD D E+ + Sbjct: 222 RPSFVKRPSNLAVTVDDSAEFKCEARG--DPVPTVRWRKD-----DGELPKSRY------ 268 Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAG 557 E+ + T L++R+V G Y CV N G + A LTV P F P D + G Sbjct: 269 EIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKA-EASATLTVQEPPHFVVKPRDQVVALG 326 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDF-----PAARERRMHVMPEDDVFFIVDVKIEDIG 612 +C A G+P P I W+++G + P R V D+ I +V+ D+G Sbjct: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVG 385 Query: 613 VYSCTAQNSAGSISANATLTVLET------PSFLRPLLDRTVTKGETAVLQCIAGGSPPP 666 Y C N AGSI A L V + P + +++TV T VL C+A GSP P Sbjct: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 445 Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-- 724 + W KD + + N +L I + + D G+YTC S G + + V Sbjct: 446 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 505 Query: 725 ------IPTPTCDSPQMTAPS 739 P PT + +APS Sbjct: 506 FGVPVQPPRPTDPNLIPSAPS 526 Score = 96.3 bits (238), Expect = 1e-19 Identities = 75/212 (35%), Positives = 102/212 (48%), Gaps = 14/212 (6%) Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDG---GTDFPAARERRMHVMPEDD 599 P + P DL + G A L C A G P P I W K G TD R RM ++P Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87 Query: 600 VFFIVDV----KIEDIGVYSCTAQNSAG-SISANATLTV-LETPSFLRPLLDRTVTKGET 653 +FF+ V D GVY C A+N G ++S NA+L V + F + D V GE Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147 Query: 654 AVLQC-IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712 AV++C G P P ++W KD SPL + G +L+I + SDAGKY C +N Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY-TRKSDAGKYVCVGTNM 206 Query: 713 LGTERGNV-RLSVIPTPT-CDSPQMTAPSLDD 742 +G V L+V+ P+ P A ++DD Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDD 238 >gi|4506569 roundabout 1 isoform a [Homo sapiens] Length = 1651 Score = 124 bits (312), Expect = 4e-28 Identities = 81/252 (32%), Positives = 118/252 (46%), Gaps = 23/252 (9%) Query: 471 TFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSS 530 T +WKKD L D + + +GG++M + + GKY CV +N G Sbjct: 201 TISWKKDGSPLDDKD----ERITIRGGKLM-------ITYTRKSDAGKYVCVGTNMVGER 249 Query: 531 YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARER 590 S A+LTV PSF K P +L + A +C A G P P + W+KD G + P +R Sbjct: 250 ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR-- 306 Query: 591 RMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK 650 + + +D I V D+G Y+C A+N G A+ATLTV E P F+ D+ V Sbjct: 307 --YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL 364 Query: 651 GETAVLQCIAGGSPPPKLNWTKDDSPLVV-------TERHFFAAGNQLLIIVDSDVSDAG 703 G T QC A G+P P + W ++ S ++ + F + L I + SD G Sbjct: 365 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 424 Query: 704 KYTCEMSNTLGT 715 Y C+ N G+ Sbjct: 425 YYICQTLNVAGS 436 Score = 111 bits (278), Expect = 3e-24 Identities = 86/298 (28%), Positives = 124/298 (41%), Gaps = 13/298 (4%) Query: 434 DDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 493 +DFP P+I P KG + C A T W K E + + + +H Sbjct: 64 EDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 120 Query: 494 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML-PSFTKTPMDL 552 + + I+ R+ EG Y CV N+ G + S A L V +L F + P D+ Sbjct: 121 LLPSGSLFFLRIVHGRKSR-PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 179 Query: 553 TIRAGAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611 + G A +EC GHP P I+W+KDG ++ + I + D Sbjct: 180 MVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDA 235 Query: 612 GVYSCTAQNSAGSISAN-ATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNW 670 G Y C N G + A LTVLE PSF++ + VT ++A +C A G P P + W Sbjct: 236 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 295 Query: 671 TKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 KDD L + + + L I D G YTC N +G + L+V P Sbjct: 296 RKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351 Score = 109 bits (272), Expect = 2e-23 Identities = 90/321 (28%), Positives = 131/321 (40%), Gaps = 35/321 (10%) Query: 438 KPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGG 497 +P +P + + F C A D T W+KD D E+ + Sbjct: 261 RPSFVKRPSNLAVTVDDSAEFKCEARG--DPVPTVRWRKD-----DGELPKSRY------ 307 Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAG 557 E+ + T L++R+V G Y CV N G + A LTV P F P D + G Sbjct: 308 EIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKA-EASATLTVQEPPHFVVKPRDQVVALG 365 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDF-----PAARERRMHVMPEDDVFFIVDVKIEDIG 612 +C A G+P P I W+++G + P R V D+ I +V+ D+G Sbjct: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVG 424 Query: 613 VYSCTAQNSAGSISANATLTVLET------PSFLRPLLDRTVTKGETAVLQCIAGGSPPP 666 Y C N AGSI A L V + P + +++TV T VL C+A GSP P Sbjct: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 484 Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-- 724 + W KD + + N +L I + + D G+YTC S G + + V Sbjct: 485 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 544 Query: 725 ------IPTPTCDSPQMTAPS 739 P PT + +APS Sbjct: 545 FGVPVQPPRPTDPNLIPSAPS 565 Score = 96.3 bits (238), Expect = 1e-19 Identities = 75/212 (35%), Positives = 102/212 (48%), Gaps = 14/212 (6%) Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDG---GTDFPAARERRMHVMPEDD 599 P + P DL + G A L C A G P P I W K G TD R RM ++P Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 126 Query: 600 VFFIVDV----KIEDIGVYSCTAQNSAG-SISANATLTV-LETPSFLRPLLDRTVTKGET 653 +FF+ V D GVY C A+N G ++S NA+L V + F + D V GE Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186 Query: 654 AVLQC-IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712 AV++C G P P ++W KD SPL + G +L+I + SDAGKY C +N Sbjct: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY-TRKSDAGKYVCVGTNM 245 Query: 713 LGTERGNV-RLSVIPTPT-CDSPQMTAPSLDD 742 +G V L+V+ P+ P A ++DD Sbjct: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDD 277 >gi|4758460 glycoprotein V (platelet) [Homo sapiens] Length = 560 Score = 124 bits (310), Expect = 6e-28 Identities = 105/379 (27%), Positives = 183/379 (48%), Gaps = 9/379 (2%) Query: 29 IKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSL 87 +++ S S + L+ + ++++ + + P + L L+ N+I + L + L Sbjct: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124 Query: 88 ETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRIS 145 E L L N + + Q F L L+ L LN N++ + F NL N L +L L+ N ++ Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLEN-LKLLDLSGNNLT 183 Query: 146 AIPPKMFKLP-QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSN 204 +P + +L+ L L+ N++ ++D LGAL L+ RN + + GAF L N Sbjct: 184 HLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPN 243 Query: 205 MEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLS 264 + L L N+L + L L L +N + + + L EL L L Sbjct: 244 LSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLR 303 Query: 265 RLDDSSFLGLSLLNTLHIG-NNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFS 323 L ++F LS L L + + R+S + AF+GL L+ L L +N ++ + D G Sbjct: 304 TLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLT-ALPD--GLLR 360 Query: 324 GLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNT 383 GL KLR++ L+ NR+R++ + F L +LE + L N + +L G+ F + +L ++ L Sbjct: 361 GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH 420 Query: 384 SSLLCDCQLKWLPQWVAEN 402 +S CDC L W+ ++ Sbjct: 421 NSWRCDCGLGPFLGWLRQH 439 Score = 102 bits (253), Expect = 2e-21 Identities = 86/302 (28%), Positives = 136/302 (45%), Gaps = 32/302 (10%) Query: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEILPE 79 L HN L I + L +L+E+ LN N+L+ +P +L N+ LL L+GN + + Sbjct: 129 LDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKG 188 Query: 80 HLKEFQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137 L LE L L SN + L + L L + N + S+ PG FD L N L L Sbjct: 189 LLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPN-LSSL 247 Query: 138 KLNRNRISAIPPKMF-------------------------KLPQLQHLELNRNKIKNVDG 172 L+RN ++ +P +F ++ LQ L LNR +++ + Sbjct: 248 TLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPA 307 Query: 173 LTFQGLGALKSLKMQRN-GVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQE 231 F+ L L+ L + + ++ L GAF GL +++L L N LT + G L GL L++ Sbjct: 308 AAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQ 367 Query: 232 LHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIA 291 + L +N + + + L + L N L L F L L + +G+N S+ Sbjct: 368 VSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN--SWRC 425 Query: 292 DC 293 DC Sbjct: 426 DC 427 >gi|118572606 hemicentin 1 [Homo sapiens] Length = 5635 Score = 123 bits (309), Expect = 8e-28 Identities = 87/292 (29%), Positives = 130/292 (44%), Gaps = 17/292 (5%) Query: 437 PKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQG 496 P P I V P + G C S+ D +T W++++ D + A +R Sbjct: 519 PPPVIQV-PNNVTVTPGERAVLTCLIISAVDYNLT--WQRNDR---DVRLAEPARIRTLA 572 Query: 497 GEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRA 556 +E L+ V+F G+Y C++S+ GSS + LTV P T P + + Sbjct: 573 NLSLE------LKSVKFNDAGEYHCMVSSEGGSS-AASVFLTVQEPPKVTVMPKNQSFTG 625 Query: 557 GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616 G+ + C+A G+P P+IAW + + R R M D FI + +D G+Y C Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYR----MTSDGTLFIKNAAPKDAGIYGC 681 Query: 617 TAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSP 676 A NSAG+ N+TL +E P + + V G+ V++C G PPP++ W K D Sbjct: 682 LASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLE 741 Query: 677 LVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 L + LL I ++ DAG YTC N G G + L V P Sbjct: 742 LRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPP 793 Score = 120 bits (301), Expect = 7e-27 Identities = 82/288 (28%), Positives = 128/288 (44%), Gaps = 19/288 (6%) Query: 446 ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 505 E + I + +S C +++ P T W KD L ++ L GG V Sbjct: 2785 EAKDVIINNPISLYCE--TNAAPPPTLTWYKDGHPLTSSDKV----LILPGGRV------ 2832 Query: 506 LRLREVEFASEGKYQCVISNHFGSS---YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARL 562 L++ + G+Y CV N G Y V+ + + + + P ++T+ A + Sbjct: 2833 LQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALI 2892 Query: 563 ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 622 EC + G PAP+ +WQKDG P + + + I++ +I DIG Y C A+N+A Sbjct: 2893 ECLSSGSPAPRNSWQKDGQ---PLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTA 2949 Query: 623 GSISANATLTVLETPSFLRPLLDR-TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTE 681 GS L V PS + P + TV L C G PPP L+W K++ P+ + Sbjct: 2950 GSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNT 3009 Query: 682 RHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 G + L I+ + VSD G+YTC N G + L+V P+ Sbjct: 3010 NTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057 Score = 120 bits (300), Expect = 9e-27 Identities = 80/283 (28%), Positives = 132/283 (46%), Gaps = 21/283 (7%) Query: 452 KGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREV 511 +G ++S C P T W KD L ++A+G E+++ IL+L+ + Sbjct: 2306 RGKSISLECEVQGIP--PPTVTWMKDGHPL----------IKAKGVEILDEGHILQLKNI 2353 Query: 512 EFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT---KTPMDLTIRAGAMARLECAAVG 568 + G+Y CV N G + K L+V+ PS ++P ++++ L C A G Sbjct: 2354 HVSDTGRYVCVAVNVAGMT-DKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASG 2412 Query: 569 HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628 P P I W KDG +P + + ++ + ++ +ED G Y+C +N+AG Sbjct: 2413 IPLPSITWFKDG---WPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKI 2469 Query: 629 ATLTVLETPSFL--RPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFA 686 L+VL P + L D V + ++ L C G+P P++ W KD PL E H Sbjct: 2470 FGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHII 2529 Query: 687 AGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 +G + L I + V G+YTC S+ G + + L+V +PT Sbjct: 2530 SGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPT 2572 Score = 113 bits (282), Expect = 1e-24 Identities = 87/331 (26%), Positives = 145/331 (43%), Gaps = 24/331 (7%) Query: 445 PETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTT 504 PE + ++ + + ++ P T AW K+++ +EN L + ++ + Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK-----RIENSDSLEVR---ILSGGS 3207 Query: 505 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIRAGAMARL 562 L++ + + G Y C+ SN G + L++ + PS + P D+++ G L Sbjct: 3208 KLQIARSQHSDSGNYTCIASNMEGKAQKYYF-LSIQVPPSVAGAEIPSDVSVLLGENVEL 3266 Query: 563 ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 622 C A G P P I W KDG + R+ V I D G Y+C A N A Sbjct: 3267 VCNANGIPTPLIQWLKDG-KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPA 3325 Query: 623 GSISANATLTVLETPSFL--RPLLDRTVTKGETAV-LQCIAGGSPPPKLNWTKDDSPLVV 679 G L V TP+ + ++ +T +T++ ++C A G+PPP++NW K+ PL + Sbjct: 3326 GEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPL 3385 Query: 680 TERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPS 739 + A Q++ IV + VSD YTC SN G + + L V P D+ T Sbjct: 3386 SSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEI 3445 Query: 740 LDDDGWATVGVVIIAVVCCVVGT---SLVWV 767 G +T ++ C GT S+ W+ Sbjct: 3446 TVLKGSST------SMACITDGTPAPSMAWL 3470 Score = 112 bits (281), Expect = 1e-24 Identities = 78/280 (27%), Positives = 130/280 (46%), Gaps = 30/280 (10%) Query: 471 TFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSS 530 + +W KD + L + +++ ++ A G L+++E + + G+Y CV SN G Sbjct: 2705 SLSWYKDGQPL---KSDDHVNIAANGHT-------LQIKEAQISDTGRYTCVASNIAGED 2754 Query: 531 YSVKAKLTVNMLPSFTKT----PMDLTIRAGAMA--------RLECAAVGHPAPQIAWQK 578 + + + + PSF K M T R G L C P P + W K Sbjct: 2755 -ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYK 2813 Query: 579 DGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPS 638 DG P ++ ++P V I K+ED G Y+C A N AG S + VL P Sbjct: 2814 DG---HPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870 Query: 639 FLRPLLDR----TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLII 694 D TV ++A+++C++ GSP P+ +W KD PL+ + H F + ++L I Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQI 2930 Query: 695 VDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQ 734 +++ ++D G+Y C NT G+ + L+V P+ P+ Sbjct: 2931 LNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970 Score = 111 bits (277), Expect = 4e-24 Identities = 77/278 (27%), Positives = 125/278 (44%), Gaps = 16/278 (5%) Query: 460 CSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKY 519 C AA + +T W KDN LL + + + R Q I+ + + + G Y Sbjct: 1942 CKAAGNPVPVIT--WYKDNRLLSGSTSMTFLN-RGQ---------IIDIESAQISDAGIY 1989 Query: 520 QCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKD 579 +CV N G++ + L V++ PS + + + + RLEC A G PAP + W KD Sbjct: 1990 KCVAINSAGAT-ELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKD 2048 Query: 580 GGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF 639 G ++ + V+ + + +I D G Y+C A N+AG + L V P+ Sbjct: 2049 GSP--VSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNI 2106 Query: 640 LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDV 699 + + +V + L C + PPP L W KD PL+ + +L I D+ V Sbjct: 2107 MGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQV 2166 Query: 700 SDAGKYTCEMSNTLGTERGNVRLSV-IPTPTCDSPQMT 736 D G+YTCE +N G N +++ +P S ++T Sbjct: 2167 QDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELT 2204 Score = 109 bits (273), Expect = 1e-23 Identities = 78/289 (26%), Positives = 125/289 (43%), Gaps = 19/289 (6%) Query: 445 PETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTT 504 P S + G N+ +C+A + +P+ W KD + + E E + A G + Y Sbjct: 3253 PSDVSVLLGENVELVCNA-NGIPTPL-IQWLKDGKPIASGETERI-RVSANGSTLNIYGA 3309 Query: 505 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD---LTIRAGAMAR 561 + + GKY CV +N G + L V + P+ + L Sbjct: 3310 LT-------SDTGKYTCVATNPAGEEDRI-FNLNVYVTPTIRGNKDEAEKLMTLVDTSIN 3361 Query: 562 LECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNS 621 +EC A G P PQI W K+G P + ++ V IV ++ D+ VY+C A N Sbjct: 3362 IECRATGTPPPQINWLKNG---LPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNR 3418 Query: 622 AGSISANATLTVLETPSFLRPL--LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVV 679 AG + + L V P+ + + TV KG + + CI G+P P + W +D PL + Sbjct: 3419 AGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGL 3478 Query: 680 TERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 + +L ++ ++ D+GKYTC SN G + L V+ P Sbjct: 3479 DAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP 3527 Score = 103 bits (258), Expect = 7e-22 Identities = 85/291 (29%), Positives = 122/291 (41%), Gaps = 17/291 (5%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P I QP I + + C A + +T W+K+ ++ + N+A L + G Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFIT--WQKEGINVNTSG-RNHAVLPSGG-- 4042 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558 L++ G Y CV N G++ K KL V + P + + I Sbjct: 4043 -------LQISRAVREDAGTYMCVAQNPAGTALG-KIKLNVQVPPVISPHLKEYVIAVDK 4094 Query: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618 L C A G P P I W KDG + R+R + I V+ D G Y+C A Sbjct: 4095 PITLSCEADGLPPPDITWHKDGRAIVESIRQRVL----SSGSLQIAFVQPGDAGHYTCMA 4150 Query: 619 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 678 N AGS S + LTV P TV + A+L C+A G P P +NW KD+ L Sbjct: 4151 ANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLA 4210 Query: 679 VTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 + A LI+ + + D+G YTC +N G + V L+V PT Sbjct: 4211 NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPT 4261 Score = 103 bits (256), Expect = 1e-21 Identities = 73/281 (25%), Positives = 117/281 (41%), Gaps = 12/281 (4%) Query: 448 QSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILR 507 QS + N S + + W+KD +L N+A ++E L Sbjct: 3720 QSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAG----NHARY-----SILE-NGFLH 3769 Query: 508 LREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAV 567 ++ G+Y C+ +N G+ + L V++ PS P ++T+ L C A Sbjct: 3770 IQSAHVTDTGRYLCMATNAAGTDRR-RIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEAT 3828 Query: 568 GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISA 627 G P P I W+K+G + + + + I+ ++D Y CT N AG Sbjct: 3829 GIPKPSINWRKNGHL-LNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKR 3887 Query: 628 NATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAA 687 LTV PS D VTK AV+ C A G P P ++WTK+ L+ + Sbjct: 3888 TVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRIL 3947 Query: 688 GNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 + + I+ + ++ AG+YTC N G+ +V L V P Sbjct: 3948 SSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPP 3988 Score = 102 bits (254), Expect = 2e-21 Identities = 78/287 (27%), Positives = 118/287 (41%), Gaps = 20/287 (6%) Query: 446 ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 505 E S I + L C A+ MT W KD L + GGEV Sbjct: 3536 EEISVIVNNPLELTCIASGIPAPKMT--WMKDGRPLPQTDQVQ----TLGGGEV------ 3583 Query: 506 LRLREVEFASEGKYQCVISNHFGSS---YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARL 562 LR+ + G+Y C+ S+ G Y V+ + N+ + T P D+T+ L Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNI--AGTDEPRDITVLRNRQVTL 3641 Query: 563 ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 622 EC + P P I W ++G R+ ++ I + + D Y+C A N A Sbjct: 3642 ECKSDAVPPPVITWLRNGER---LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIA 3698 Query: 623 GSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTER 682 G + LTV P+ + ++ VL+CIA G P P++ W KD + L Sbjct: 3699 GKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHA 3758 Query: 683 HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 + N L I + V+D G+Y C +N GT+R + L V P+ Sbjct: 3759 RYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPS 3805 Score = 102 bits (254), Expect = 2e-21 Identities = 78/256 (30%), Positives = 107/256 (41%), Gaps = 18/256 (7%) Query: 474 WKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSV 533 WKKDN LL + G E L L V G Y CV +N G Sbjct: 4202 WKKDNVLLANL----------LGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHT 4251 Query: 534 KAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMH 593 LTV++LP+FT+ P D+++ G RL C A G P P++ W + PA Sbjct: 4252 -VSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNI-IPA----HFD 4305 Query: 594 VMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK-GE 652 + I V ED G Y CTA+NS G + A + V E P F + G Sbjct: 4306 SVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGG 4365 Query: 653 TAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712 A+L C G P P + W + + ++ R GN L I + DAG YTC +N Sbjct: 4366 NAILNCEVKGDPTPTIQWNRKGVDIEISHR-IRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424 Query: 713 LGTERGNVRLSVIPTP 728 G ++ L++ P Sbjct: 4425 AGVVERSMSLTLQSPP 4440 Score = 102 bits (253), Expect = 2e-21 Identities = 77/285 (27%), Positives = 119/285 (41%), Gaps = 19/285 (6%) Query: 455 NLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFA 514 N S + SS +W+KD + L +E+ H G IL++ + Sbjct: 2887 NKSALIECLSSGSPAPRNSWQKDGQPL----LEDDHHKFLSNGR------ILQILNTQIT 2936 Query: 515 SEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD-LTIRAGAMARLECAAVGHPAPQ 573 G+Y CV N GS+ L V++ PS + LT+ L C G P P Sbjct: 2937 DIGRYVCVAENTAGSAKKY-FNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPD 2995 Query: 574 IAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 633 ++W K+ + P ++P I+ K+ D G Y+C A N AG +LTV Sbjct: 2996 LSWLKN---EQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052 Query: 634 LETPSFL----RPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGN 689 PS L V +G + L+C + PPP + W K+ + + A Sbjct: 3053 YVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG 3112 Query: 690 QLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQ 734 Q+L I ++VSD G+Y C N G + N L+V P+ + P+ Sbjct: 3113 QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPE 3157 Score = 101 bits (252), Expect = 3e-21 Identities = 69/210 (32%), Positives = 101/210 (48%), Gaps = 8/210 (3%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 L++ V+ G Y C+ +N GSS S KLTV++ P T T+ + A L C Sbjct: 4133 LQIAFVQPGDAGHYTCMAANVAGSS-STSTKLTVHVPPRIRSTEGHYTVNENSQAILPCV 4191 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G P P I W+KD + A + + +V +ED G Y+C A N+AG Sbjct: 4192 ADGIPTPAINWKKD---NVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGED 4248 Query: 626 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685 + +LTV P+F D ++ KGE L C A G P PKL WT +++ + HF Sbjct: 4249 THTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN---IIPAHFD 4305 Query: 686 AA-GNQLLIIVDSDVSDAGKYTCEMSNTLG 714 + G+ L+I D+G Y C N++G Sbjct: 4306 SVNGHSELVIERVSKEDSGTYVCTAENSVG 4335 Score = 98.2 bits (243), Expect = 4e-20 Identities = 63/245 (25%), Positives = 107/245 (43%), Gaps = 9/245 (3%) Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIR 555 E+++ +L L+ +G+YQC +SN G + KLT+ + PS D+++ Sbjct: 1502 ELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQ-AKDIKLTIYIPPSIKGGNVTTDISVL 1560 Query: 556 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615 ++ +LEC G P P I W KDG P + + + I ++ D Y+ Sbjct: 1561 INSLIKLECETRGLPMPAITWYKDGQ---PIMSSSQALYIDKGQYLHIPRAQVSDSATYT 1617 Query: 616 CTAQNSAGSISANATLTVLETPSF---LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTK 672 C N AG+ + + V P L L++ V + L+C A G+P P L W K Sbjct: 1618 CHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLK 1677 Query: 673 DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732 D P+ + AG + L I+ + D G+Y C ++ G + + V+ P + Sbjct: 1678 DGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEG 1737 Query: 733 PQMTA 737 T+ Sbjct: 1738 GDETS 1742 Score = 97.4 bits (241), Expect = 6e-20 Identities = 77/297 (25%), Positives = 122/297 (41%), Gaps = 21/297 (7%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P I + + S + + +C S + P T W KD L L+ G Sbjct: 2104 PNIMGEEQNVSVLISQAVELLCQ--SDAIPPPTLTWLKDGHPL----------LKKPGLS 2151 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSS---YSVKAKLTVNMLPSFTKTPMDLTIR 555 + E ++L++ + + G+Y C +N G + Y+V + N+ S T LT+ Sbjct: 2152 ISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELT--QLTVI 2209 Query: 556 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615 G + L C + G P P + W+K G + R + ++ I + D +YS Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGR-VRILSGGRQLQISIAEKSDAALYS 2268 Query: 616 CTAQNSAGSISANATLTVLETPSFLRPLLDRT---VTKGETAVLQCIAGGSPPPKLNWTK 672 C A N AG+ L V P+ T VT+G++ L+C G PPP + W K Sbjct: 2269 CVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMK 2328 Query: 673 DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 D PL+ + +L + + VSD G+Y C N G LSV P+ Sbjct: 2329 DGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPS 2385 Score = 96.7 bits (239), Expect = 1e-19 Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 23/303 (7%) Query: 445 PETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTT 504 PE S ++ +++S C A+ +T W KD + N + + G Sbjct: 2393 PENISVVEKNSVSLTCEASGIPLPSIT--WFKDG---WPVSLSNSVRILSGG-------R 2440 Query: 505 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIRAGAMARL 562 +LRL + G+Y CV+ N G + L+V + P T D+ ++ L Sbjct: 2441 MLRLMQTTMEDAGQYTCVVRNAAGEERKIFG-LSVLVPPHIVGENTLEDVKVKEKQSVTL 2499 Query: 563 ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 622 C G+P P+I W KDG P + H++ I +V++ G Y+C A + A Sbjct: 2500 TCEVTGNPVPEITWHKDGQ---PLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPA 2556 Query: 623 GSISANATLTVLETPSFLRPLLDR-----TVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 G S + +L V +P+ D TV L C A PP + W KD +PL Sbjct: 2557 GHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPL 2616 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTA 737 G + L I+++ +AG+Y+C +N G + + V P + + Sbjct: 2617 ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWG 2676 Query: 738 PSL 740 P L Sbjct: 2677 PGL 2679 Score = 96.7 bits (239), Expect = 1e-19 Identities = 78/297 (26%), Positives = 119/297 (40%), Gaps = 15/297 (5%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P I P + I + C A + W+K+ LL+ + +N L + G Sbjct: 3804 PSIAPGPTNMTVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSL 3861 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558 V+ ++ Y+C ++N G LTV + PS P D + A Sbjct: 3862 VIISPSV--------DDTATYECTVTNGAGDDKRT-VDLTVQVPPSIADEPTDFLVTKHA 3912 Query: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618 A + C A G P P I W K+G P R+ I+ ++ G Y+C A Sbjct: 3913 PAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRIL---SSGAIEILATQLNHAGRYTCVA 3969 Query: 619 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 678 +N+AGS + TL V E P + V +L C A G+P P + W K+ + Sbjct: 3970 RNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVN 4029 Query: 679 VTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 735 + R+ + L I + DAG Y C N GT G ++L+V P SP + Sbjct: 4030 TSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNV-QVPPVISPHL 4085 Score = 95.5 bits (236), Expect = 2e-19 Identities = 78/318 (24%), Positives = 138/318 (43%), Gaps = 25/318 (7%) Query: 422 SIFAVSPDGFVCDDFPKPQIT---VQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDN 478 ++ + F D + P I P + + +L+ C AA + +T W KD Sbjct: 1622 NVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILT--WLKDG 1679 Query: 479 ELLHDAEMENYAHLRAQ-GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKL 537 ++ ++R + GG+ +E I+ +E++ G+Y CV ++ G +K ++ Sbjct: 1680 -----VPVKANDNIRIEAGGKKLE---IMSAQEID---RGQYICVATSVAGEK-EIKYEV 1727 Query: 538 TVNMLPSFT--KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVM 595 V + P+ + + L+C G P P I W KDG ++ Sbjct: 1728 DVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQL---IDERDGFKIL 1784 Query: 596 PEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRP-LLDRTVTKGETA 654 I ++ + G+Y C A N+AG +TV P+ L +R V K + Sbjct: 1785 LNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844 Query: 655 VLQCIAGGSPPPKLNWTKDDSPLVVTERHF-FAAGNQLLIIVDSDVSDAGKYTCEMSNTL 713 LQCIA G P P + W KDD P+ + + + ++L I + + DAG+YTC +N Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA 1904 Query: 714 GTERGNVRLSVIPTPTCD 731 G + +++L V P+ + Sbjct: 1905 GETQQHIQLHVHEPPSLE 1922 Score = 95.5 bits (236), Expect = 2e-19 Identities = 72/266 (27%), Positives = 121/266 (45%), Gaps = 20/266 (7%) Query: 469 PMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFG 528 P T W KD +L+ + + G +++ L + + + ++ G Y+C+ +N G Sbjct: 1763 PPTIMWLKDGQLIDERD----------GFKILLNGRKLVIAQAQVSNTGLYRCMAANTAG 1812 Query: 529 SSYSVKAKLTVNMLPSFTKTPMD--LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPA 586 + + ++TV++ P+ + + + ++ +A L+C A G P P I W KD D P Sbjct: 1813 D-HKKEFEVTVHVPPTIKSSGLSERVVVKYKPVA-LQCIANGIPNPSITWLKD---DQPV 1867 Query: 587 -ARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF--LRPL 643 + + + V I +ED G Y+C A N+AG + L V E PS + Sbjct: 1868 NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKM 1927 Query: 644 LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAG 703 L+ TV L+C A G+P P + W KD+ L + F Q++ I + +SDAG Sbjct: 1928 LNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAG 1987 Query: 704 KYTCEMSNTLGTERGNVRLSVIPTPT 729 Y C N+ G L V P+ Sbjct: 1988 IYKCVAINSAGATELFYSLQVHVAPS 2013 Score = 94.0 bits (232), Expect = 7e-19 Identities = 79/307 (25%), Positives = 122/307 (39%), Gaps = 36/307 (11%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLH------DAEMENYAHL 492 P I + S I+G ++ C A S + + W K EL+ A + ++ Sbjct: 981 PTIQHGQQILSTIEGIPVTLPCKA--SGNPKPSVIWSKKGELISTSSAKFSAGADGSLYV 1038 Query: 493 RAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF------- 545 + GGE G+Y C +N G + K +LTV + P Sbjct: 1039 VSPGGE----------------ESGEYVCTATNTAGYAKR-KVQLTVYVRPRVFGDQRGL 1081 Query: 546 -TKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIV 604 P+++++ AG L C P P I W K+ P + H I Sbjct: 1082 SQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPR---HTFLPSGSMKIT 1138 Query: 605 DVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSP 664 + + D G+Y C A N AG+++ L V P R V G+ + C A G+P Sbjct: 1139 ETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTP 1198 Query: 665 PPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724 P + W+K S ++V H + + L I + SDAG YTC +N GT+ + L V Sbjct: 1199 LPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHV 1258 Query: 725 IPTPTCD 731 PT + Sbjct: 1259 QEPPTVE 1265 Score = 93.6 bits (231), Expect = 9e-19 Identities = 72/269 (26%), Positives = 113/269 (42%), Gaps = 27/269 (10%) Query: 474 WKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSV 533 W KD + L + E AH GG ++ T V+ G+Y C+ S+ G S Sbjct: 2513 WHKDGQPLQEDE----AHHIISGGRFLQITN------VQVPHTGRYTCLASSPAGHK-SR 2561 Query: 534 KAKLTVNMLPSFTKT-----PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAAR 588 L V + P+ P D+T+ + L C A +P I W KDG P Sbjct: 2562 SFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGT---PLES 2618 Query: 589 ERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLL---- 644 R + ++P I++ + ++ G YSC A N AG + + + V P + L Sbjct: 2619 NRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPG 2678 Query: 645 ----DRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS 700 + + T L+C A P L+W KD PL + AA L I ++ +S Sbjct: 2679 LSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQIS 2738 Query: 701 DAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 D G+YTC SN G + + +++ P+ Sbjct: 2739 DTGRYTCVASNIAGEDELDFDVNIQVPPS 2767 Score = 93.2 bits (230), Expect = 1e-18 Identities = 67/218 (30%), Positives = 93/218 (42%), Gaps = 5/218 (2%) Query: 517 GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 576 G+Y CV N GS++ L V+ P P +L + L C A G P+P I W Sbjct: 3963 GRYTCVARNAAGSAHR-HVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITW 4021 Query: 577 QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET 636 QK+G + R V+P + V+ ED G Y C AQN AG+ L V Sbjct: 4022 QKEGINVNTSGRNHA--VLPSGGLQISRAVR-EDAGTYMCVAQNPAGTALGKIKLNVQVP 4078 Query: 637 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVD 696 P L + + + L C A G PPP + W KD +V + R + L I Sbjct: 4079 PVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAF- 4137 Query: 697 SDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQ 734 DAG YTC +N G+ + +L+V P S + Sbjct: 4138 VQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTE 4175 Score = 89.7 bits (221), Expect = 1e-17 Identities = 63/228 (27%), Positives = 98/228 (42%), Gaps = 7/228 (3%) Query: 505 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLTIRAGAMARL 562 IL+L G+Y C N G+S + V + P+ T P ++++ L Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQKY-FNIDVLVPPTIIGTNFPNEVSVVLNRDVAL 1473 Query: 563 ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 622 EC G P P I W KDG F + + ++ V + + + D G Y CT N+A Sbjct: 1474 ECQVKGTPFPDIHWFKDGKPLFLG--DPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAA 1531 Query: 623 GSISANATLTVLETPSFL--RPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVT 680 G + + LT+ PS D +V L+C G P P + W KD P++ + Sbjct: 1532 GKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSS 1591 Query: 681 ERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 + + Q L I + VSD+ YTC ++N GT + + V P Sbjct: 1592 SQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPP 1639 Score = 89.4 bits (220), Expect = 2e-17 Identities = 65/244 (26%), Positives = 104/244 (42%), Gaps = 12/244 (4%) Query: 505 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLEC 564 +L+++E + G Y CV N G + K L V P F + P D+++ G+ L C Sbjct: 756 LLKIQETQDLDAGDYTCVAINEAGRATG-KITLDVGSPPVFIQEPADVSMEIGSNVTLPC 814 Query: 565 AAVGHPAPQIAWQK-DGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAG 623 G+P P I W++ D F FI+++ D G Y C A+N G Sbjct: 815 YVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFG 874 Query: 624 SISANATLTVLETPSFLRPLLD-----RTVTKGETAVLQC-IAGGSPPPKLNWTKDDSPL 677 I + T+TV + PL+ V +G+ L C + G+P P+ W K+ S + Sbjct: 875 KIQSETTVTVT---GLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN-SAM 930 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTA 737 ++ + + L I + D G+YTC SN GT + V PT Q Sbjct: 931 LLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL 990 Query: 738 PSLD 741 +++ Sbjct: 991 STIE 994 Score = 89.0 bits (219), Expect = 2e-17 Identities = 71/290 (24%), Positives = 119/290 (41%), Gaps = 21/290 (7%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P++TV P+ QS GS +S +CSA + AW ++ + + ++ + G Sbjct: 612 PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKI--AWTVNDMFI----VGSHRYRMTSDGT 665 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558 + ++ G Y C+ SN G+ + L P +L + G Sbjct: 666 LF-------IKNAAPKDAGIYGCLASNSAGTDKQ-NSTLRYIEAPKLMVVQSELLVALGD 717 Query: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618 + +EC G P PQ+ W K D + + P + I + + D G Y+C A Sbjct: 718 ITVMECKTSGIPPPQVKWFKG---DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVA 774 Query: 619 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 678 N AG + TL V P F++ D ++ G L C G P P + W + D+ + Sbjct: 775 INEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI 834 Query: 679 VTERHFFAAGNQL----LIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724 + ++ +QL L I++ SD G Y CE N G + ++V Sbjct: 835 FSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV 884 Score = 79.3 bits (194), Expect = 2e-14 Identities = 74/306 (24%), Positives = 125/306 (40%), Gaps = 23/306 (7%) Query: 430 GFVCDDFPKPQITVQ-PETQSAIKGSNLSFICSAASSSDSPMTFAWKK-DNELLHDA--E 485 G + D P + +Q P S GSN++ C + T W++ DN + Sbjct: 783 GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEP--TIKWRRLDNMPIFSRPFS 840 Query: 486 MENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML--P 543 + + + LR T L + + + +G Y C N FG S + +TV L P Sbjct: 841 VSSISQLR---------TGALFILNLWASDKGTYICEAENQFGKIQS-ETTVTVTGLVAP 890 Query: 544 SFTKTPMDLTIRAGAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 602 +P + G L C + G+P P+ W K+ + + D Sbjct: 891 LIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAM----LLQNPYITVRSDGSLH 946 Query: 603 IVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGG 662 I V+++D G Y+C A N AG+ + ++ V P+ + +G L C A G Sbjct: 947 IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASG 1006 Query: 663 SPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRL 722 +P P + W+K + + F A + L +V ++G+Y C +NT G + V+L Sbjct: 1007 NPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQL 1066 Query: 723 SVIPTP 728 +V P Sbjct: 1067 TVYVRP 1072 Score = 76.3 bits (186), Expect = 1e-13 Identities = 72/300 (24%), Positives = 113/300 (37%), Gaps = 33/300 (11%) Query: 450 AIKGSNL---------SFICSAASSSDSPM-TFAWKKDNELLHDAEMENYAHLRAQGGEV 499 +IKG N+ S I + PM W KD + + + Y Sbjct: 1547 SIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALY---------- 1596 Query: 500 MEYTTILRLREVEFASEGKYQCVISNHFGS---SYSVKAKLTVNMLPSFTKTPMDLTIRA 556 ++ L + + + Y C ++N G+ S+ V + M+ TP++ + Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPP-MIEGNLATPLNKQVVI 1655 Query: 557 GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616 LEC A G+P+P + W KDG P + + I+ + D G Y C Sbjct: 1656 AHSLTLECKAAGNPSPILTWLKDG---VPVKANDNIRIEAGGKKLEIMSAQEIDRGQYIC 1712 Query: 617 TAQNSAGSISANATLTVLETPSFLRPLLDRT----VTKGETAVLQCIAGGSPPPKLNWTK 672 A + AG + VL P+ D T V L C GSPPP + W K Sbjct: 1713 VATSVAGEKEIKYEVDVLVPPAIEGG--DETSYFIVMVNNLLELDCHVTGSPPPTIMWLK 1770 Query: 673 DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732 D + + + L+I + VS+ G Y C +NT G + ++V PT S Sbjct: 1771 DGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKS 1830 Score = 74.7 bits (182), Expect = 4e-13 Identities = 68/278 (24%), Positives = 103/278 (37%), Gaps = 21/278 (7%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P T P S KG L C A +T W +N ++ AH + G Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLT--WTFNNNIIP-------AHFDSVNGH 4310 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT-PMDLTIRAG 557 + L + V G Y C N G ++ + V P F P + G Sbjct: 4311 -----SELVIERVSKEDSGTYVCTAENSVGFVKAI-GFVYVKEPPVFKGDYPSNWIEPLG 4364 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 A L C G P P I W + G + R R++ + I ED G Y+C Sbjct: 4365 GNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLG----NGSLAIYGTVNEDAGDYTCV 4420 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 A N AG + + +LT+ P ++ + G +L C A G P P + W++ + Sbjct: 4421 ATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSI 4480 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGT 715 +R N L I D+ D ++ C N +G+ Sbjct: 4481 SWDDR-VNVLSNNSLYIADAQKEDTSEFECVARNLMGS 4517 Score = 67.0 bits (162), Expect = 9e-11 Identities = 70/298 (23%), Positives = 117/298 (39%), Gaps = 22/298 (7%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P+I P+ G + C+A + +T++ K + +L D E H+ G Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWS-KGGSTMLVDGEH----HVSNPDGT 1225 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIR- 555 L + + + G Y CV +N G+ + L V P+ + P + T + Sbjct: 1226 -------LSIDQATPSDAGIYTCVATNIAGTD-ETEITLHVQEPPTVEDLEPPYNTTFQE 1277 Query: 556 --AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGV 613 A C A G P P I W +G RE + ++ + + I V D G Sbjct: 1278 RVANQRIEFPCPAKGTPKPTIKWLHNGRE--LTGREPGISILEDGTLLVIASVTPYDNGE 1335 Query: 614 YSCTAQNSAGSISANATLTVLETPSFL--RPLLDRTVTKGETAVLQCIAGGSPPPKLNWT 671 Y C A N AG+ L V P + + +V + L C G+P P + W Sbjct: 1336 YICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY 1395 Query: 672 KDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 KD+ + + ++L + + DAG+Y+C+ N GT + + V+ PT Sbjct: 1396 KDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPT 1453 Score = 60.1 bits (144), Expect = 1e-08 Identities = 55/216 (25%), Positives = 92/216 (42%), Gaps = 17/216 (7%) Query: 603 IVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGG 662 I V + D G Y C A +SAG+ A V E P ++ + TVT GE AVL C+ Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIIS 545 Query: 663 SPPPKLNWTKDDSPLVVTE-RHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVR 721 + L W ++D + + E N L + +DAG+Y C +S+ G+ +V Sbjct: 546 AVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF 605 Query: 722 LSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVG---TSLVWVV-----IIYHT 773 L+V + P++T + + G ++++C G + W V + H Sbjct: 606 LTV-----QEPPKVTVMPKNQ---SFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHR 657 Query: 774 RRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQD 809 R D ++ + A I L+S D+Q+ Sbjct: 658 YRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQN 693 Score = 58.5 bits (140), Expect = 3e-08 Identities = 35/117 (29%), Positives = 54/117 (46%), Gaps = 5/117 (4%) Query: 517 GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 576 G Y CV +N G LT+ P T P++ I AG L C A G P P I W Sbjct: 4415 GDYTCVATNEAGV-VERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473 Query: 577 QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 633 + G + + + R++V+ + ++ I D + ED + C A+N GS+ + V Sbjct: 4474 SRQGHS---ISWDDRVNVLSNNSLY-IADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526 >gi|15029530 leucine rich repeat containing 4 [Homo sapiens] Length = 653 Score = 121 bits (304), Expect = 3e-27 Identities = 104/375 (27%), Positives = 171/375 (45%), Gaps = 21/375 (5%) Query: 158 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 217 ++L L N I+ + TF+ L L+ L++ RN + ++ GAF GL+++ L+L N LT Sbjct: 78 RYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTV 137 Query: 218 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSL 276 I G L L+EL L N I I A+ L LDL L + + +F GL Sbjct: 138 IPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFN 197 Query: 277 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 336 L L++G + + + L L+ L++ N E G+F GL L++L + + Sbjct: 198 LKYLNLGMCNIKDMPNLT--PLVGLEELEMSGNHFP---EIRPGSFHGLSSLKKLWVMNS 252 Query: 337 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP 396 ++ I + AF GL +L L+L+ N + SL + F+ ++ L +LHL+ + CDC + WL Sbjct: 253 QVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLA 312 Query: 397 QWVAEN-NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSN 455 W+ E S C P ++GR + V F C P I P + +G Sbjct: 313 WWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCS---APFIMDAPRDLNISEGRM 369 Query: 456 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515 C S + W LL + + ++A + + + T L V + Sbjct: 370 AELKCRTPPMS----SVKW-----LLPNGTVLSHASRHPRISVLNDGT--LNFSHVLLSD 418 Query: 516 EGKYQCVISNHFGSS 530 G Y C+++N G+S Sbjct: 419 TGVYTCMVTNVAGNS 433 Score = 67.8 bits (164), Expect = 5e-11 Identities = 62/222 (27%), Positives = 93/222 (41%), Gaps = 48/222 (21%) Query: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79 +L N L+ I + + +L LRE+ L NN +E+IP S A NR+ ++ Sbjct: 129 ELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIP------------SYAFNRVPSLMRL 176 Query: 80 HLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLK 138 L E + LE + + AF L LKYL L + M Sbjct: 177 DLGELKKLEYIS---------EGAFEGLFNLKYLNLGMCNIKDM---------------- 211 Query: 139 LNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGA 198 P + L L+ LE++ N + +F GL +LK L + + V+ + A Sbjct: 212 ----------PNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNA 261 Query: 199 FWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 240 F GL+++ L L HNNL+ + L L ELHL N N Sbjct: 262 FDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWN 303 Score = 52.4 bits (124), Expect = 2e-06 Identities = 71/272 (26%), Positives = 107/272 (39%), Gaps = 47/272 (17%) Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFP-AARERRMHVMPEDDVF 601 P P DL I G MA L+C P + W GT A+R R+ V+ + + Sbjct: 353 PFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLSHASRHPRISVLNDGTLN 410 Query: 602 FIVDVKIEDIGVYSCTAQNSAGSISANATLTV----LETPSFLRPLLDRTVTKGETAVLQ 657 F V + D GVY+C N AG+ +A+A L V L T ++ TVT T + Sbjct: 411 FS-HVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNY---SFFTTVTVETTEI-- 464 Query: 658 CIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTER 717 SP + T+ P+ T + A YT + + T R Sbjct: 465 -----SPE---DTTRKYKPVPTTSTGYQPA-----------------YTTSTTVLIQTTR 499 Query: 718 GNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRN 777 +++V T T D Q SLD+ T +II V + +++ Y R+R+ Sbjct: 500 VPKQVAVPATDTTDKMQ---TSLDEVMKTT--KIIIGCFVAVTLLAAAMLIVFYKLRKRH 554 Query: 778 EDCSITNTDET----NLPADIPSYLSSQGTLA 805 + S T + DIP+ S+ T A Sbjct: 555 QQRSTVTAARTVEIIQVDEDIPAATSAAATAA 586 >gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3874 Score = 120 bits (302), Expect = 5e-27 Identities = 86/291 (29%), Positives = 129/291 (44%), Gaps = 15/291 (5%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P I P ++ ++ ++++ C A S P +W K ++ + G Sbjct: 695 PNIEPGPVNKAVLENASVTLECLA--SGVPPPDVSWFKGHQPVSSW----------MGVT 742 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-MDLTIRAG 557 V +LR+ + + + G Y+CV SN GS+ ++ L VN+ P T P + + Sbjct: 743 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGST-ELRYGLRVNVPPRITLPPSLPGPVLVN 801 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 RL C A G P+P + W KDG PA + V P V + + D G YSC Sbjct: 802 TPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG-LQVFPGGRVLTLASARASDSGRYSCV 860 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 A ++ G + L V PS L L+ +V E+ L+C + PPP L+W KD PL Sbjct: 861 AVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL 920 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 +A LL + +DV DAG YTCE N G + L+V P Sbjct: 921 EPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAP 971 Score = 114 bits (285), Expect = 5e-25 Identities = 77/269 (28%), Positives = 120/269 (44%), Gaps = 18/269 (6%) Query: 473 AWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS 532 +W+KD + L E H+ A G +L L + + A EG Y C SN G+S S Sbjct: 1004 SWRKDGQPL-PGEGAGLQHVSAVG-------RLLYLGQAQLAQEGTYTCECSNVVGNS-S 1054 Query: 533 VKAKLTVNMLPSFT---KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARE 589 +L V++ P + P +++ +A LEC A G P P + W++DG P E Sbjct: 1055 QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ---PVGAE 1111 Query: 590 RRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF---LRPLLDR 646 + + + + + G YSC A+N AG L+VL P L PL + Sbjct: 1112 LGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI 1171 Query: 647 TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYT 706 T L C A G PPP + W + + P+ E + AG +L + + D+G Y+ Sbjct: 1172 TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYS 1231 Query: 707 CEMSNTLGTERGNVRLSVIPTPTCDSPQM 735 C SN G R N + V+ P+ ++ + Sbjct: 1232 CLASNEAGEARRNFSVEVLVPPSIENEDL 1260 Score = 106 bits (265), Expect = 1e-22 Identities = 83/292 (28%), Positives = 133/292 (45%), Gaps = 22/292 (7%) Query: 444 QPETQ-SAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEY 502 +P TQ S ++ + C+A P T W++D + + AE+ G ++ Sbjct: 1072 EPPTQVSVVQDGVATLECNATGKP--PPTVTWERDGQPV-GAEL---------GLQLQNQ 1119 Query: 503 TTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAM--- 559 L + + A G+Y CV N G + K +L+V + P LT A+ Sbjct: 1120 GQSLHVERAQAAHTGRYSCVAENLAGRAER-KFELSVLVPPELIGDLDPLTNITAALHSP 1178 Query: 560 ARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQ 619 L C A+G P P I W + + P + +++ + + + +D G+YSC A Sbjct: 1179 LTLLCEAMGIPPPAIRWFRG---EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 1235 Query: 620 NSAGSISANATLTVLETPSFLRPLLDRT--VTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 N AG N ++ VL PS L+ V G+TA L C G P PKL W KD PL Sbjct: 1236 NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1295 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 + H + LL ++ +++S AG Y+C +N +G + + +LSV+ PT Sbjct: 1296 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT 1347 Score = 106 bits (265), Expect = 1e-22 Identities = 71/242 (29%), Positives = 111/242 (45%), Gaps = 9/242 (3%) Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD-LTIRA 556 +V+E +L++ E A Y CV N GS+ + L V + P ++ +T Sbjct: 1702 QVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT-LRVQVPPRIAGLDLEQVTAIL 1760 Query: 557 GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616 + L C HP P++ W KD + + ++P + ++ D G+Y+C Sbjct: 1761 NSSVSLPCDVHAHPNPEVTWYKDSQA---LSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 1817 Query: 617 TAQNSAGSISANATLTVLETPSFLR----PLLDRTVTKGETAVLQCIAGGSPPPKLNWTK 672 A N+AG L+VL P+F + P V G+ AVL C P P + W K Sbjct: 1818 EALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK 1877 Query: 673 DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732 D PLV+ +R G Q L I ++ VSD G Y+C++SN G L+V PT ++ Sbjct: 1878 DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFEN 1937 Query: 733 PQ 734 P+ Sbjct: 1938 PK 1939 Score = 106 bits (264), Expect = 1e-22 Identities = 69/234 (29%), Positives = 107/234 (45%), Gaps = 15/234 (6%) Query: 505 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML--PSFTKTPMDLTIRA--GAMA 560 +L++ + + G Y C+ SN G + + +V +L PS ++ I+ G A Sbjct: 1216 MLKMTQTQEQDSGLYSCLASNEAGEA---RRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 1272 Query: 561 RLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQN 620 L C GHP P++ W KDG P AR H+ P+ + ++ + G YSC A N Sbjct: 1273 HLMCNVTGHPQPKLTWFKDGR---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1329 Query: 621 SAGSISANATLTVLETPSFLRPLLDR-----TVTKGETAVLQCIAGGSPPPKLNWTKDDS 675 + G + + L+VL P+ L D TVT L C A P P + W KD + Sbjct: 1330 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1389 Query: 676 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 P + G L I+++ DAG+YTC ++N LG N + V+ P+ Sbjct: 1390 PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1443 Score = 105 bits (261), Expect = 3e-22 Identities = 122/478 (25%), Positives = 184/478 (38%), Gaps = 75/478 (15%) Query: 386 LLCDCQLKWLPQ--WVAENNFQSFVNASCAHPQLLKGR-----SIFAVSPDGFVCDDF-- 436 LLCD Q P W + + + + ++L+ R + A SP G + F Sbjct: 2324 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 2383 Query: 437 --PKPQITVQPETQSAIKG---SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAH 491 P V P + G L CS + +T W +D +L + AH Sbjct: 2384 RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT--WHRDGIVLQED-----AH 2436 Query: 492 LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD 551 + E L+L+ + A G Y C N GS+ SV ++ ++ +P+ P Sbjct: 2437 T-----QFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTVPTIRSGPPA 2490 Query: 552 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611 + + A L C A G PAP ++W+KD P R R ++PE + I V +D Sbjct: 2491 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP--RSPRFEILPEGSLR-IQPVLAQDA 2547 Query: 612 GVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWT 671 G Y C A NSAGS L VLE P+ + T+T A+L C A GSP P + W Sbjct: 2548 GHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWW 2607 Query: 672 KDDSPL--VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 KD L + + + + L++ D+ ++ C +SN +G +++V PT Sbjct: 2608 KDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2667 Query: 730 CDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETN 789 DD TV ++ V+ C T Sbjct: 2668 I---------ADDQTDFTVTMMAPVVLTC---------------------------HSTG 2691 Query: 790 LPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSS 847 +PA S+ + L R GY S SG+ G LP H TC NS+ Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGYRVSPSGALE-------IGQALPIHAGRYTCSARNSA 2742 Score = 104 bits (260), Expect = 4e-22 Identities = 67/209 (32%), Positives = 97/209 (46%), Gaps = 6/209 (2%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 LR+ G Y C+ N GS+ K +L V + P DL+ G+ A L C Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMG-KTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2869 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G P P I W KDG + E + + P ++ + +++ +D G Y+CTA+N+ G Sbjct: 2870 ARGSPEPNITWDKDGQP--VSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRA 2926 Query: 626 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685 LT+L P F DR++ G+ L+C A GSP P++ WT +D P VTE Sbjct: 2927 RRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP--VTEGVSE 2984 Query: 686 AAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714 G L D+G Y C N +G Sbjct: 2985 QDGGSTLQRAAVSREDSGTYVCWAENRVG 3013 Score = 104 bits (259), Expect = 5e-22 Identities = 71/212 (33%), Positives = 92/212 (43%), Gaps = 5/212 (2%) Query: 517 GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 576 G+Y C N G ++ LTV P P + A L C A G P P I W Sbjct: 2732 GRYTCSARNSAGVAHK-HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW 2790 Query: 577 QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET 636 QK+G A V+P + I ED G Y C A+NSAGS L V Sbjct: 2791 QKEG---LNVATGVSTQVLPGGQLR-IAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVP 2846 Query: 637 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVD 696 P L D + T+G A L C A GSP P + W KD P+ E F + L++ + Sbjct: 2847 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKN 2906 Query: 697 SDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 + DAG YTC N +G R V L+++ P Sbjct: 2907 LEGQDAGTYTCTAENAVGRARRRVHLTILVLP 2938 Score = 93.2 bits (230), Expect = 1e-18 Identities = 83/294 (28%), Positives = 125/294 (42%), Gaps = 25/294 (8%) Query: 446 ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 505 ET S + GS L C S +P T W KD + + + ++GG Sbjct: 1941 ETVSQVAGSPLVLTCDV-SGVPAP-TVTWLKDRMPVESSAVHGVV---SRGGR------- 1988 Query: 506 LRLREVEFASEGKYQCVISNHFGSSYS--VKAKLTVNMLPSFTKTPMDLTIRAGAMARLE 563 L+L ++ A G Y CV N + V A L + S + + + G RL+ Sbjct: 1989 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS-SGVAREHHVLEGQEVRLD 2047 Query: 564 CAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIV--DVKIEDIGVYSCTAQNS 621 C A G P P +AW KDG P ++ H+ D +V ++ D G Y+C A N Sbjct: 2048 CEADGQPPPDVAWLKDGS---PLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNP 2104 Query: 622 AGSISANATLTVLETPSFLRPLLDRTVT----KGETAVLQCIAGGSPPPKLNWTKDDSPL 677 AG + T+ VL P+ ++ D + T GE + C GSPP ++W KD PL Sbjct: 2105 AGEDARLHTVNVLVPPT-IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL 2163 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCD 731 +++R L I ++DAG +TC ++ G N L V P + Sbjct: 2164 PLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE 2217 Score = 92.4 bits (228), Expect = 2e-18 Identities = 69/227 (30%), Positives = 101/227 (44%), Gaps = 7/227 (3%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 L++ +V+ EG Y C +N G S A L V + P+ P++ + A LEC Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECL 717 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G P P ++W K P + + V + V I ++ D G Y C A N AGS Sbjct: 718 ASGVPPPDVSWFKGHQ---PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 774 Query: 626 SANATLTVLETPSF-LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL--VVTER 682 L V P L P L V L C A G+P P L W KD +P+ T Sbjct: 775 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 834 Query: 683 HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 G ++L + + SD+G+Y+C + +G +R +V L V P+ Sbjct: 835 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 881 Score = 90.9 bits (224), Expect = 6e-18 Identities = 78/272 (28%), Positives = 120/272 (44%), Gaps = 18/272 (6%) Query: 463 ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 522 AS S P+ WK +L D ++ QG + + L L +++CV Sbjct: 2596 ASGSPKPLVVWWKDGQKL--DFRLQ-------QGAYRLLPSNALLLTAPGPQDSAQFECV 2646 Query: 523 ISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGT 582 +SN G ++ + ++TV++ P+ D T+ A L C + G PAP ++W K G Sbjct: 2647 VSNEVGEAHRLY-QVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 2705 Query: 583 DFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRP 642 AR V P + + I G Y+C+A+NSAG + LTV +P ++P Sbjct: 2706 --LGARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFLTVQASP-VVKP 2761 Query: 643 L--LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS 700 L + R V + E +L C A G P P + W K+ + G QL I + Sbjct: 2762 LPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRI-AHASPE 2819 Query: 701 DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732 DAG Y C N+ G+ G RL V P ++ Sbjct: 2820 DAGNYLCIAKNSAGSAMGKTRLVVQVPPVIEN 2851 Score = 89.7 bits (221), Expect = 1e-17 Identities = 76/294 (25%), Positives = 112/294 (38%), Gaps = 18/294 (6%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P I + S + +++ C S + P +W KD L E HL A Sbjct: 880 PSILGEELNVSVVANESVALECQ--SHAMPPPVLSWWKDGRPL---EPRPGVHLSAD--- 931 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT-KTPMDLTIRAG 557 +L++ + G Y C N G S L V + P F + LT+R G Sbjct: 932 ----KALLQVDRADVWDAGHYTCEALNQAGRSEK-HYNLNVWVAPVFPLRESHTLTVREG 986 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 L C G P P+I+W+KD G P HV + ++ ++ G Y+C Sbjct: 987 HPTSLSCECRGVPFPKISWRKD-GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 1045 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRT---VTKGETAVLQCIAGGSPPPKLNWTKDD 674 N G+ S + L V P P T V + A L+C A G PPP + W +D Sbjct: 1046 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDG 1105 Query: 675 SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 P+ Q L + + + G+Y+C N G LSV+ P Sbjct: 1106 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP 1159 Score = 86.3 bits (212), Expect = 1e-16 Identities = 74/300 (24%), Positives = 120/300 (40%), Gaps = 43/300 (14%) Query: 456 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515 +S IC A + +T W KD A E +++ G T L++ + Sbjct: 1368 ISLICEALAFPSPNIT--WMKDG-----APFEASRNIQLLPG-----THGLQILNAQKED 1415 Query: 516 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-------MDLTIRAGAMARLECAAVG 568 G+Y CV++N G + + V + PS +K ++ + + LEC + Sbjct: 1416 AGQYTCVVTNELGEAVK-NYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 1474 Query: 569 HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628 P P I W KDG P R+ V+ E + I ++ D G Y C A N AG + Sbjct: 1475 VPPPTIRWYKDGQ---PVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD 1531 Query: 629 ATLTVLETPSFLR--------PLLDRT------------VTKGETAVLQCIAGGSPPPKL 668 + + P F + +L R + + A L C PPP L Sbjct: 1532 FNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL 1591 Query: 669 NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 W ++D PL + G ++L I +AG+Y+C+ SN +G + + L V+ P Sbjct: 1592 TWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 1651 Score = 84.3 bits (207), Expect = 5e-16 Identities = 62/223 (27%), Positives = 95/223 (42%), Gaps = 2/223 (0%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 LR++ V G Y C+ SN GS + L V P+ +P +LT+ A A L C Sbjct: 2537 LRIQPVLAQDAGHYLCLASNSAGSDRQGR-DLRVLEPPAIAPSPSNLTLTAHTPALLPCE 2595 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G P P + W KDG ++ ++P + + +D + C N G Sbjct: 2596 ASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP-QDSAQFECVVSNEVGEA 2654 Query: 626 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685 +TV P+ D TVT VL C + G P P ++W+K + L + Sbjct: 2655 HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYR 2714 Query: 686 AAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 + + L I + AG+YTC N+ G +V L+V +P Sbjct: 2715 VSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP 2757 Score = 83.2 bits (204), Expect = 1e-15 Identities = 82/311 (26%), Positives = 121/311 (38%), Gaps = 26/311 (8%) Query: 425 AVSPDGFVCDDFP-----KPQITVQPET-QSAIKGSNLSFICSAASSSDSPMTFAWKKDN 478 A SP G DF P I ET + A+ +L + A +P W KD Sbjct: 291 AFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP-NITWFKDG 349 Query: 479 ELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLT 538 LL + Y +GG L+L + + G Y C SN G++ +L Sbjct: 350 ALLPTSTKVVYT----RGGRQ------LQLGRAQSSDAGVYTCKASNAVGAAEKA-TRLD 398 Query: 539 VNMLPSFTKT---PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVM 595 V + P+ P + AG LEC A GHP+P ++W +G P A + Sbjct: 399 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG---LPVAESNESRLE 455 Query: 596 PEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFL--RPLLDRTVTKGET 653 + V + G+YSC A + AG ++ V P L L T G+ Sbjct: 456 TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQP 515 Query: 654 AVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTL 713 L C A GSP P + W ++ P A+ L I ++ +G + C+ +N Sbjct: 516 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 575 Query: 714 GTERGNVRLSV 724 GT V +SV Sbjct: 576 GTAGAEVEVSV 586 Score = 83.2 bits (204), Expect = 1e-15 Identities = 83/320 (25%), Positives = 124/320 (38%), Gaps = 40/320 (12%) Query: 425 AVSPDGFVCDDFPKPQITVQPETQSA--------IKGSNLSFICSAASSSDSPMTFAWKK 476 A SP G +F Q+ V P + ++GS + C A P+ +W K Sbjct: 2195 AASPAGVADRNFTL-QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVP-LPLV-SWMK 2251 Query: 477 DNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAK 536 D E L +E QG L+L V G Y CV + G + + Sbjct: 2252 DGEPLLSQSLE-------QGPS-------LQLEAVGAGDSGTYSCVAVSEAGEARR-HFQ 2296 Query: 537 LTVNMLPSFTKT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHV 594 LTV P + P +L++ GA L C A G P P I W KDG R Sbjct: 2297 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATR 2356 Query: 595 MPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT--KGE 652 + +++ D G+Y+C A++ AG+I + + V P+ + P R V Sbjct: 2357 V----------LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG 2406 Query: 653 TAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712 VL+C P PK+ W +D L F + L + +D+G Y+C N Sbjct: 2407 QLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 2466 Query: 713 LGTERGNVRLSVIPTPTCDS 732 G+ R+ + PT S Sbjct: 2467 AGSTSVAFRVEIHTVPTIRS 2486 Score = 80.9 bits (198), Expect = 6e-15 Identities = 56/183 (30%), Positives = 79/183 (43%), Gaps = 14/183 (7%) Query: 556 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615 AGA L+C G P PQ+ W KD P + V + V I + D G Y Sbjct: 231 AGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPH--LQVQEDGQVLRITGSHVGDEGRYQ 288 Query: 616 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQ-------CIAGGSPPPKL 668 C A + AG + + L V P+ + GE AV++ C A G P P + Sbjct: 289 CVAFSPAGQQARDFQLRVHAPPTIWG-----SNETGEVAVMEDHLVQLLCEARGVPTPNI 343 Query: 669 NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 W KD + L + + + G + L + + SDAG YTC+ SN +G RL V P Sbjct: 344 TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP 403 Query: 729 TCD 731 T + Sbjct: 404 TIE 406 Score = 79.7 bits (195), Expect = 1e-14 Identities = 76/299 (25%), Positives = 108/299 (36%), Gaps = 21/299 (7%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P T P +S G L C AA S +P W ++ + + E GG Sbjct: 2938 PVFTTLPGDRSLRLGDRLWLRC-AARGSPTPR-IGWTVNDRPVTEGVSEQ------DGGS 2989 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR-AG 557 ++ + R G Y C N G + +V + V P + G Sbjct: 2990 TLQRAAVSR------EDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQGEAFSYLVEPVG 3042 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 +L+C G P P I W KDG P H + ++ I + +D G Y C Sbjct: 3043 GSIQLDCVVRGDPVPDIHWIKDG---LPLRGSHLRHQL-QNGSLTIHRTERDDAGRYQCL 3098 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 A+N G L + P F D TV G+ L+C A G P P + W + PL Sbjct: 3099 AENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3158 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMT 736 + R + L + + + DAG Y C N LG+ L V P MT Sbjct: 3159 RAS-RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMT 3216 Score = 74.7 bits (182), Expect = 4e-13 Identities = 67/264 (25%), Positives = 107/264 (40%), Gaps = 27/264 (10%) Query: 496 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS-VKAKLTVNMLPSFTKTPMDL-- 552 G +V T L + VE G + C +N G++ + V+ + P + P+ Sbjct: 544 GVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYH 603 Query: 553 -------TIRAGAMARLECAAVGHPAPQIA--WQKDGG-----TDFPAARERRMHVMPED 598 + A + HP P + W G T P A + +P Sbjct: 604 WGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVA-----YSLPPP 658 Query: 599 DVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQC 658 I V + D G+Y+C A N AG L VL P+ +++ V + + L+C Sbjct: 659 --LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLEC 716 Query: 659 IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTE-- 716 +A G PPP ++W K P+ + ++L I + +SDAG Y C SN G+ Sbjct: 717 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 776 Query: 717 RGNVRLSVIPTPTCDSPQMTAPSL 740 R +R++V P T P + P L Sbjct: 777 RYGLRVNVPPRITL-PPSLPGPVL 799 Score = 72.4 bits (176), Expect = 2e-12 Identities = 58/228 (25%), Positives = 93/228 (40%), Gaps = 21/228 (9%) Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLTIR 555 +V E +LR+ EG+YQCV + G + +L V+ P+ + ++ + Sbjct: 266 QVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVM 324 Query: 556 AGAMARLECAAVGHPAPQIAWQKDGG-----TDFPAARERRMHVMPEDDVFFIVDVKIED 610 + +L C A G P P I W KDG T R R + + D Sbjct: 325 EDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGR--------AQSSD 376 Query: 611 IGVYSCTAQNSAGSISANATLTVLETPSFL----RPLLDRTVTKGETAVLQCIAGGSPPP 666 GVY+C A N+ G+ L V P+ RP + + V G L+C+A G P P Sbjct: 377 AGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA-GRPVALECVARGHPSP 435 Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714 L+W + P+ + +L + + +G Y+C S+ G Sbjct: 436 TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG 483 Score = 72.0 bits (175), Expect = 3e-12 Identities = 73/296 (24%), Positives = 114/296 (38%), Gaps = 41/296 (13%) Query: 469 PMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFG 528 P T W KD + + + +V+ +L+++ + + G+Y CV +N G Sbjct: 1477 PPTIRWYKDGQPVTPSSRL----------QVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1526 Query: 529 SSYSVKAKLTVNMLPSFTKT----------PMDLTIRAGAM----------ARLECAAVG 568 + + + P F K + R G A L C Sbjct: 1527 ED-DQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNA 1585 Query: 569 HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628 P P + W ++ D P + + V+ V I V+ E+ G YSC A N G + Sbjct: 1586 IPPPDLTWYRE---DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1642 Query: 629 ATLTVLETPSFL---RPLLDR-TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHF 684 L VL P L L++ TV T LQC A G+P P ++W ++ P + R Sbjct: 1643 YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQ 1702 Query: 685 FAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT---CDSPQMTA 737 Q+L + ++V+DA Y C N G+ L V P D Q+TA Sbjct: 1703 VLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1758 Score = 71.2 bits (173), Expect = 5e-12 Identities = 72/268 (26%), Positives = 99/268 (36%), Gaps = 31/268 (11%) Query: 492 LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD 551 L Q G + L L V A G Y+C +N GS+ S +AKL V + PS + Sbjct: 45 LHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST-SRRAKLVVYVPPSIREDGRK 103 Query: 552 LTIR--AGAMARLECAAVGHPAPQIAWQKDG------------GTDFPAARERRMHVMPE 597 + AG LEC A G P P+I W KD G D + ++ E Sbjct: 104 ANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 163 Query: 598 DDVFFIVDVKIEDIGVYSC----TAQNSAGSISANATLTVLETPSFLRPLLDRTV----- 648 ++ G +AQ A + A TP P +V Sbjct: 164 GQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGA 223 Query: 649 ------TKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHF-FAAGNQLLIIVDSDVSD 701 G LQC G P P++ WTKD P++ H Q+L I S V D Sbjct: 224 AQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGD 283 Query: 702 AGKYTCEMSNTLGTERGNVRLSVIPTPT 729 G+Y C + G + + +L V PT Sbjct: 284 EGRYQCVAFSPAGQQARDFQLRVHAPPT 311 Score = 60.5 bits (145), Expect = 8e-09 Identities = 38/112 (33%), Positives = 52/112 (46%), Gaps = 4/112 (3%) Query: 564 CAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAG 623 C G P PQ+ W+K G + P + + V+ E +F + V D G Y C A N G Sbjct: 24 CGTHGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLF-LASVSPADSGDYECQATNEVG 81 Query: 624 SISANATLTVLETPSFLRPLLDRTVT--KGETAVLQCIAGGSPPPKLNWTKD 673 S S A L V PS V+ G++ L+C A G P P++ W KD Sbjct: 82 STSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKD 133 Score = 31.2 bits (69), Expect = 5.4 Identities = 18/73 (24%), Positives = 33/73 (45%), Gaps = 1/73 (1%) Query: 658 CIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQ-LLIIVDSDVSDAGKYTCEMSNTLGTE 716 C G+P P++ W K S + + A + L + +D+G Y C+ +N +G+ Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83 Query: 717 RGNVRLSVIPTPT 729 +L V P+ Sbjct: 84 SRRAKLVVYVPPS 96 >gi|157694513 leucine-rich repeat-containing G protein-coupled receptor 4 [Homo sapiens] Length = 951 Score = 120 bits (302), Expect = 5e-27 Identities = 103/391 (26%), Positives = 178/391 (45%), Gaps = 49/391 (12%) Query: 41 REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 100 R V + L +P +SA L ++ N I ++ + K F LE L L+ N++S + Sbjct: 39 RRVDCSGKGLTAVPE--GLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFI 96 Query: 101 QT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQL 157 A L +LK L L +N++ ++ L+ L L+L+ N I+++P F+ L QL Sbjct: 97 HPKALSGLKELKVLTLQNNQLKTVPSEAIRGLS-ALQSLRLDANHITSVPEDSFEGLVQL 155 Query: 158 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 217 +HL L+ N + V L L++L + N ++ + D AF LS++ +L L +N + Sbjct: 156 RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRS 215 Query: 218 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 277 +++ GL L+ L L+ N + P A + L EL N +S + D +F G LL Sbjct: 216 LSQHCFDGLDNLETLDLNYNNLGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLL 274 Query: 278 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNG----------------- 320 T+H+ +N +S++ + AF LS L +L ++ + ++ G Sbjct: 275 RTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSI 334 Query: 321 -------------------------AFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHL 355 +F+G L + LQ N+I I + F GL +L L Sbjct: 335 PNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRIL 394 Query: 356 DLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386 DLS N I + AF+ + + L ++ + L Sbjct: 395 DLSRNLIHEIHSRAFATLGPITNLDVSFNEL 425 Score = 112 bits (281), Expect = 1e-24 Identities = 75/252 (29%), Positives = 120/252 (47%), Gaps = 5/252 (1%) Query: 137 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195 L ++ N I+ +P FK P L+ L+L N + + GL LK L +Q N + + Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121 Query: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255 A GLS ++ L+LD N++T + + GL+ L+ L L N++ + L Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQA 181 Query: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 315 L L N +S + D +F LS L LH+ NN++ ++ F GL +L+TLDL N + Sbjct: 182 LTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG--- 238 Query: 316 EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 375 + A L L+ L N I I AF G L + L DN + + +AF + Sbjct: 239 -EFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSD 297 Query: 376 LQQLHLNTSSLL 387 L L + +S++ Sbjct: 298 LHSLVIRGASMV 309 Score = 104 bits (260), Expect = 4e-22 Identities = 117/436 (26%), Positives = 187/436 (42%), Gaps = 83/436 (19%) Query: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN--LGPVSANITL------------- 65 L+ N LSFI ++S L+ L+ + L NN+L+T+P+ + +SA +L Sbjct: 88 LAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPED 147 Query: 66 ----------LSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLY 113 L L N + E+ L +L+ L L+ N IS + AF L L L+ Sbjct: 148 SFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLH 207 Query: 114 LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGL 173 L++N++ S+ FD L N L L LN N + P + LP L+ L + N I + Sbjct: 208 LHNNKIRSLSQHCFDGLDN-LETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDG 266 Query: 174 TFQGLGALKSLKMQRNGVTKLMDGAFWGLSNM-----------------------EILQL 210 F G L+++ + N ++ + + AF LS++ E L L Sbjct: 267 AFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTL 326 Query: 211 DHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSS 270 ++ I ML+ L LS N I + ++ C L E+ L N + ++ + + Sbjct: 327 TGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGT 384 Query: 271 FLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI-SWTIEDMNGAFSGLDKLR 329 F GL L L + N + I AF L + LD+ NE+ S+ E +NG L Sbjct: 385 FQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNG-------LN 437 Query: 330 RLILQGN-------------RIRSITKK------AFTGLDALEHLDLSDNAIMSLQGNAF 370 +L L GN +RS++ AF G D+ +L+ DN SLQ ++ Sbjct: 438 QLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLNTEDN---SLQDHSV 494 Query: 371 SQMKKLQQLHLNTSSL 386 +Q K TS+L Sbjct: 495 AQEKGTADAANVTSTL 510 Score = 90.1 bits (222), Expect = 1e-17 Identities = 76/272 (27%), Positives = 121/272 (44%), Gaps = 17/272 (6%) Query: 158 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 217 Q L+++ N I + F+ L+ L++ N ++ + A GL +++L L +N L Sbjct: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119 Query: 218 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 277 + + GL LQ L L N I + D++E +L L L N L+ + L L Sbjct: 120 VPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179 Query: 278 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNR 337 L + N++S I D AF LSSL L L NN+I + F GLD L L L N Sbjct: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH---CFDGLDNLETLDLNYNN 236 Query: 338 IRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQ 397 + +A L +L+ L N+I + AF L+ +HL + L Sbjct: 237 LGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPL----------S 285 Query: 398 WVAENNFQSFVNASCAHPQLLKGRSIFAVSPD 429 +V + +F N S H +++G S+ P+ Sbjct: 286 FVGNS---AFHNLSDLHSLVIRGASMVQQFPN 314 >gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] Length = 5065 Score = 120 bits (301), Expect = 7e-27 Identities = 86/291 (29%), Positives = 129/291 (44%), Gaps = 15/291 (5%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P I P ++ ++ ++++ C A S P +W K ++ + G Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLA--SGVPPPDVSWFKGHQPVSSW----------MGVT 1933 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-MDLTIRAG 557 V +LR+ + + + G Y+CV SN GS+ ++ L VN+ P T P + + Sbjct: 1934 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGST-ELRYGLRVNVPPRITLPPSLPGPVLVN 1992 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 RL C A G P+P + W KDG PA + V P V + + D G YSC Sbjct: 1993 TPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG-LQVFPGGRVLTLASARASDSGRYSCV 2051 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 A ++ G + L V PS L L+ +V E+ L+C + PPP L+W KD PL Sbjct: 2052 AVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL 2111 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 +A LL + +DV DAG YTCE N G + L+V P Sbjct: 2112 EPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP 2162 Score = 114 bits (285), Expect = 5e-25 Identities = 77/269 (28%), Positives = 120/269 (44%), Gaps = 18/269 (6%) Query: 473 AWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS 532 +W+KD + L E H+ A G +L L + + A EG Y C SN G+S S Sbjct: 2195 SWRKDGQPL-PGEGAGLQHVSAVG-------RLLYLGQAQLAQEGTYTCECSNVVGNS-S 2245 Query: 533 VKAKLTVNMLPSFT---KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARE 589 +L V++ P + P +++ +A LEC A G P P + W++DG P E Sbjct: 2246 QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ---PVGAE 2302 Query: 590 RRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF---LRPLLDR 646 + + + + + G YSC A+N AG L+VL P L PL + Sbjct: 2303 LGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI 2362 Query: 647 TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYT 706 T L C A G PPP + W + + P+ E + AG +L + + D+G Y+ Sbjct: 2363 TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYS 2422 Query: 707 CEMSNTLGTERGNVRLSVIPTPTCDSPQM 735 C SN G R N + V+ P+ ++ + Sbjct: 2423 CLASNEAGEARRNFSVEVLVPPSIENEDL 2451 Score = 106 bits (265), Expect = 1e-22 Identities = 83/292 (28%), Positives = 133/292 (45%), Gaps = 22/292 (7%) Query: 444 QPETQ-SAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEY 502 +P TQ S ++ + C+A P T W++D + + AE+ G ++ Sbjct: 2263 EPPTQVSVVQDGVATLECNATGKP--PPTVTWERDGQPV-GAEL---------GLQLQNQ 2310 Query: 503 TTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAM--- 559 L + + A G+Y CV N G + K +L+V + P LT A+ Sbjct: 2311 GQSLHVERAQAAHTGRYSCVAENLAGRAER-KFELSVLVPPELIGDLDPLTNITAALHSP 2369 Query: 560 ARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQ 619 L C A+G P P I W + + P + +++ + + + +D G+YSC A Sbjct: 2370 LTLLCEAMGIPPPAIRWFRG---EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 2426 Query: 620 NSAGSISANATLTVLETPSFLRPLLDRT--VTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 N AG N ++ VL PS L+ V G+TA L C G P PKL W KD PL Sbjct: 2427 NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 2486 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 + H + LL ++ +++S AG Y+C +N +G + + +LSV+ PT Sbjct: 2487 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT 2538 Score = 106 bits (265), Expect = 1e-22 Identities = 71/242 (29%), Positives = 111/242 (45%), Gaps = 9/242 (3%) Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD-LTIRA 556 +V+E +L++ E A Y CV N GS+ + L V + P ++ +T Sbjct: 2893 QVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT-LRVQVPPRIAGLDLEQVTAIL 2951 Query: 557 GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616 + L C HP P++ W KD + + ++P + ++ D G+Y+C Sbjct: 2952 NSSVSLPCDVHAHPNPEVTWYKDSQA---LSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 3008 Query: 617 TAQNSAGSISANATLTVLETPSFLR----PLLDRTVTKGETAVLQCIAGGSPPPKLNWTK 672 A N+AG L+VL P+F + P V G+ AVL C P P + W K Sbjct: 3009 EALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK 3068 Query: 673 DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732 D PLV+ +R G Q L I ++ VSD G Y+C++SN G L+V PT ++ Sbjct: 3069 DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFEN 3128 Query: 733 PQ 734 P+ Sbjct: 3129 PK 3130 Score = 106 bits (264), Expect = 1e-22 Identities = 69/234 (29%), Positives = 107/234 (45%), Gaps = 15/234 (6%) Query: 505 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML--PSFTKTPMDLTIRA--GAMA 560 +L++ + + G Y C+ SN G + + +V +L PS ++ I+ G A Sbjct: 2407 MLKMTQTQEQDSGLYSCLASNEAGEA---RRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 2463 Query: 561 RLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQN 620 L C GHP P++ W KDG P AR H+ P+ + ++ + G YSC A N Sbjct: 2464 HLMCNVTGHPQPKLTWFKDGR---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 2520 Query: 621 SAGSISANATLTVLETPSFLRPLLDR-----TVTKGETAVLQCIAGGSPPPKLNWTKDDS 675 + G + + L+VL P+ L D TVT L C A P P + W KD + Sbjct: 2521 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 2580 Query: 676 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 P + G L I+++ DAG+YTC ++N LG N + V+ P+ Sbjct: 2581 PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 2634 Score = 105 bits (261), Expect = 3e-22 Identities = 122/478 (25%), Positives = 184/478 (38%), Gaps = 75/478 (15%) Query: 386 LLCDCQLKWLPQ--WVAENNFQSFVNASCAHPQLLKGR-----SIFAVSPDGFVCDDF-- 436 LLCD Q P W + + + + ++L+ R + A SP G + F Sbjct: 3515 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 3574 Query: 437 --PKPQITVQPETQSAIKG---SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAH 491 P V P + G L CS + +T W +D +L + AH Sbjct: 3575 RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT--WHRDGIVLQED-----AH 3627 Query: 492 LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD 551 + E L+L+ + A G Y C N GS+ SV ++ ++ +P+ P Sbjct: 3628 T-----QFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTVPTIRSGPPA 3681 Query: 552 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611 + + A L C A G PAP ++W+KD P R R ++PE + I V +D Sbjct: 3682 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP--RSPRFEILPEGSLR-IQPVLAQDA 3738 Query: 612 GVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWT 671 G Y C A NSAGS L VLE P+ + T+T A+L C A GSP P + W Sbjct: 3739 GHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWW 3798 Query: 672 KDDSPL--VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 KD L + + + + L++ D+ ++ C +SN +G +++V PT Sbjct: 3799 KDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 3858 Query: 730 CDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETN 789 DD TV ++ V+ C T Sbjct: 3859 I---------ADDQTDFTVTMMAPVVLTC---------------------------HSTG 3882 Query: 790 LPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSS 847 +PA S+ + L R GY S SG+ G LP H TC NS+ Sbjct: 3883 IPAPTVSWSKAGAQLGARGSGYRVSPSGALE-------IGQALPIHAGRYTCSARNSA 3933 Score = 104 bits (260), Expect = 4e-22 Identities = 67/209 (32%), Positives = 97/209 (46%), Gaps = 6/209 (2%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 LR+ G Y C+ N GS+ K +L V + P DL+ G+ A L C Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMG-KTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK 4060 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G P P I W KDG + E + + P ++ + +++ +D G Y+CTA+N+ G Sbjct: 4061 ARGSPEPNITWDKDGQP--VSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRA 4117 Query: 626 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685 LT+L P F DR++ G+ L+C A GSP P++ WT +D P VTE Sbjct: 4118 RRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP--VTEGVSE 4175 Query: 686 AAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714 G L D+G Y C N +G Sbjct: 4176 QDGGSTLQRAAVSREDSGTYVCWAENRVG 4204 Score = 104 bits (259), Expect = 5e-22 Identities = 87/296 (29%), Positives = 121/296 (40%), Gaps = 29/296 (9%) Query: 451 IKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLRE 510 + G N S C A + +T+ +E LH Q G + L L Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKGPSSEPLH-----------GQPGVAVLEEGSLFLAS 1267 Query: 511 VEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR--AGAMARLECAAVG 568 V A G Y+C +N GS+ S +AKL V + PS + + AG LEC A G Sbjct: 1268 VSPADSGDYECQATNEVGST-SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANG 1326 Query: 569 HPAPQIAWQKDG------------GTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616 P P+I W KD G D + ++ E ++ D G+YSC Sbjct: 1327 FPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSC 1386 Query: 617 TAQNSAGSISANATLTVLETPSFLRPLLDRTV--TKGETAVLQCIAGGSPPPKLNWTKDD 674 A+N AG+ + L VL PS L + V G LQC G P P++ WTKD Sbjct: 1387 RAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDR 1446 Query: 675 SPLVVTERHF-FAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 P++ H Q+L I S V D G+Y C + G + + +L V PT Sbjct: 1447 QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 1502 Score = 104 bits (259), Expect = 5e-22 Identities = 71/212 (33%), Positives = 92/212 (43%), Gaps = 5/212 (2%) Query: 517 GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 576 G+Y C N G ++ LTV P P + A L C A G P P I W Sbjct: 3923 GRYTCSARNSAGVAHK-HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW 3981 Query: 577 QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET 636 QK+G A V+P + I ED G Y C A+NSAGS L V Sbjct: 3982 QKEG---LNVATGVSTQVLPGGQLR-IAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVP 4037 Query: 637 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVD 696 P L D + T+G A L C A GSP P + W KD P+ E F + L++ + Sbjct: 4038 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKN 4097 Query: 697 SDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 + DAG YTC N +G R V L+++ P Sbjct: 4098 LEGQDAGTYTCTAENAVGRARRRVHLTILVLP 4129 Score = 102 bits (253), Expect = 2e-21 Identities = 75/231 (32%), Positives = 102/231 (44%), Gaps = 12/231 (5%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 LR+ + G Y C N G + S + +L V P T+ P D+T+ G A L C Sbjct: 750 LRIPAAQERDAGTYTCRAVNELGDA-SAEIQLAVGHAPQLTELPRDVTVELGRSALLACR 808 Query: 566 AVGHPAPQIAWQK-DG---GTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNS 621 A G P P + W++ DG G A R R P+ V F V ED Y C A+N Sbjct: 809 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSR-QPDSGVLFFESVAPEDQAPYVCEARNV 867 Query: 622 AGSISANATLTVL--ETPSFLRPLLDRTVTKGETAVLQCIA-GGSPPPKLNWTKDDSPLV 678 G + A A L V P V +G+ L CI G P P+ +W KD PL Sbjct: 868 FGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP 927 Query: 679 VTERHFFAAGNQLLIIVDSDVSD-AGKYTCEMSNTLGTERGNVRLSVIPTP 728 RH A L + D + + AG+Y+C +NT G++ +V L V P Sbjct: 928 PGSRHSIRADGSLHL--DRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 976 Score = 97.4 bits (241), Expect = 6e-20 Identities = 73/229 (31%), Positives = 105/229 (45%), Gaps = 17/229 (7%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 LRL +V+ G Y+C SN GS+ S + L V + P P L + G L C Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSA-SHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCV 1142 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G+P PQ++W KDG + R P+ V F ++ D G Y C A NSAG Sbjct: 1143 AEGNPEPQLSWSKDG-----VVLQGR---GPQGSVHFAA-IRTSDAGRYRCEASNSAGVD 1193 Query: 626 SANATLTVLETPSF----LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTE 681 + L VLE P + LL+R GE A L C A G+P P++ W K S + Sbjct: 1194 AWEVELRVLEPPHWGADETSGLLERVA--GENASLPCPARGTPKPQVTWRKGPSSEPLHG 1251 Query: 682 RHFFAAGNQ-LLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 + A + L + +D+G Y C+ +N +G+ +L V P+ Sbjct: 1252 QPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPS 1300 Score = 96.3 bits (238), Expect = 1e-19 Identities = 78/293 (26%), Positives = 118/293 (40%), Gaps = 29/293 (9%) Query: 437 PKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQG 496 P P +TV P + + S ++P W +D + L A Sbjct: 522 PAPNVTVSPGETAVL---------SCRVLGEAPYNLTWVRD-----------WRVLPAST 561 Query: 497 GEVMEYTTI-LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR 555 G V + + L + + G+YQCV SN G + + L V P + Sbjct: 562 GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA-SVWLLVREAPQVSIHTSSQHFS 620 Query: 556 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615 G ++ C+A G+P P I+W ++ + R+HV + + I V ED G YS Sbjct: 621 QGVEVKVSCSASGYPTPHISWSRESQA---LQEDSRIHVDAQGTLI-IQGVAPEDAGNYS 676 Query: 616 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS 675 C A N G+ TL + PS V GE AVL C A G PPP++ W + Sbjct: 677 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 736 Query: 676 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 +++ + + L I + DAG YTC N LG ++L+V P Sbjct: 737 EMILAPE---GSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 786 Score = 94.7 bits (234), Expect = 4e-19 Identities = 78/290 (26%), Positives = 119/290 (41%), Gaps = 16/290 (5%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 PQ+T P + G + C A P T W++ + + R++ + Sbjct: 786 PQLTELPRDVTVELGRSALLACRATGRP--PPTVTWRRGDGQPLGLRLGAGRGSRSRQPD 843 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV--NMLPSFTKTPMDLTIRA 556 + +L V + Y C N FG +A+L V + P + + + Sbjct: 844 ----SGVLFFESVAPEDQAPYVCEARNVFGK-VQAEARLIVTGHAPPQIASSAPTVRVLE 898 Query: 557 GAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615 G L C + G P P+ W KDG P +R H + D + E G YS Sbjct: 899 GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSR----HSIRADGSLHLDRALQEHAGRYS 954 Query: 616 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVT-KGETAVLQCIAGGSPPPKLNWTKDD 674 C A N+AGS + L V++ P + P +T +G A L C+A G P P + WTK+ Sbjct: 955 CVATNTAGSQHRDVEL-VVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 1013 Query: 675 SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724 + L H+ + L+I DAG Y C +NT+G +RLSV Sbjct: 1014 NALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063 Score = 93.2 bits (230), Expect = 1e-18 Identities = 83/294 (28%), Positives = 125/294 (42%), Gaps = 25/294 (8%) Query: 446 ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 505 ET S + GS L C S +P T W KD + + + ++GG Sbjct: 3132 ETVSQVAGSPLVLTCDV-SGVPAP-TVTWLKDRMPVESSAVHGVV---SRGGR------- 3179 Query: 506 LRLREVEFASEGKYQCVISNHFGSSYS--VKAKLTVNMLPSFTKTPMDLTIRAGAMARLE 563 L+L ++ A G Y CV N + V A L + S + + + G RL+ Sbjct: 3180 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS-SGVAREHHVLEGQEVRLD 3238 Query: 564 CAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIV--DVKIEDIGVYSCTAQNS 621 C A G P P +AW KDG P ++ H+ D +V ++ D G Y+C A N Sbjct: 3239 CEADGQPPPDVAWLKDGS---PLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNP 3295 Query: 622 AGSISANATLTVLETPSFLRPLLDRTVT----KGETAVLQCIAGGSPPPKLNWTKDDSPL 677 AG + T+ VL P+ ++ D + T GE + C GSPP ++W KD PL Sbjct: 3296 AGEDARLHTVNVLVPPT-IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL 3354 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCD 731 +++R L I ++DAG +TC ++ G N L V P + Sbjct: 3355 PLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE 3408 Score = 92.4 bits (228), Expect = 2e-18 Identities = 69/227 (30%), Positives = 101/227 (44%), Gaps = 7/227 (3%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 L++ +V+ EG Y C +N G S A L V + P+ P++ + A LEC Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECL 1908 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G P P ++W K P + + V + V I ++ D G Y C A N AGS Sbjct: 1909 ASGVPPPDVSWFKGHQ---PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 1965 Query: 626 SANATLTVLETPSF-LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL--VVTER 682 L V P L P L V L C A G+P P L W KD +P+ T Sbjct: 1966 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 2025 Query: 683 HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 G ++L + + SD+G+Y+C + +G +R +V L V P+ Sbjct: 2026 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 2072 Score = 90.9 bits (224), Expect = 6e-18 Identities = 78/272 (28%), Positives = 120/272 (44%), Gaps = 18/272 (6%) Query: 463 ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 522 AS S P+ WK +L D ++ QG + + L L +++CV Sbjct: 3787 ASGSPKPLVVWWKDGQKL--DFRLQ-------QGAYRLLPSNALLLTAPGPQDSAQFECV 3837 Query: 523 ISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGT 582 +SN G ++ + ++TV++ P+ D T+ A L C + G PAP ++W K G Sbjct: 3838 VSNEVGEAHRLY-QVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 3896 Query: 583 DFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRP 642 AR V P + + I G Y+C+A+NSAG + LTV +P ++P Sbjct: 3897 --LGARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFLTVQASP-VVKP 3952 Query: 643 L--LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS 700 L + R V + E +L C A G P P + W K+ + G QL I + Sbjct: 3953 LPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRI-AHASPE 4010 Query: 701 DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732 DAG Y C N+ G+ G RL V P ++ Sbjct: 4011 DAGNYLCIAKNSAGSAMGKTRLVVQVPPVIEN 4042 Score = 89.7 bits (221), Expect = 1e-17 Identities = 76/294 (25%), Positives = 112/294 (38%), Gaps = 18/294 (6%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P I + S + +++ C S + P +W KD L E HL A Sbjct: 2071 PSILGEELNVSVVANESVALECQ--SHAMPPPVLSWWKDGRPL---EPRPGVHLSAD--- 2122 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT-KTPMDLTIRAG 557 +L++ + G Y C N G S L V + P F + LT+R G Sbjct: 2123 ----KALLQVDRADVWDAGHYTCEALNQAGHSEK-HYNLNVWVAPVFPLRESHTLTVREG 2177 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 L C G P P+I+W+KD G P HV + ++ ++ G Y+C Sbjct: 2178 HPTSLSCECRGVPFPKISWRKD-GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 2236 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRT---VTKGETAVLQCIAGGSPPPKLNWTKDD 674 N G+ S + L V P P T V + A L+C A G PPP + W +D Sbjct: 2237 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDG 2296 Query: 675 SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 P+ Q L + + + G+Y+C N G LSV+ P Sbjct: 2297 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP 2350 Score = 86.3 bits (212), Expect = 1e-16 Identities = 74/300 (24%), Positives = 120/300 (40%), Gaps = 43/300 (14%) Query: 456 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515 +S IC A + +T W KD A E +++ G T L++ + Sbjct: 2559 ISLICEALAFPSPNIT--WMKDG-----APFEASRNIQLLPG-----THGLQILNAQKED 2606 Query: 516 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-------MDLTIRAGAMARLECAAVG 568 G+Y CV++N G + + V + PS +K ++ + + LEC + Sbjct: 2607 AGQYTCVVTNELGEAVK-NYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 2665 Query: 569 HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628 P P I W KDG P R+ V+ E + I ++ D G Y C A N AG + Sbjct: 2666 VPPPTIRWYKDGQ---PVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD 2722 Query: 629 ATLTVLETPSFLR--------PLLDRT------------VTKGETAVLQCIAGGSPPPKL 668 + + P F + +L R + + A L C PPP L Sbjct: 2723 FNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL 2782 Query: 669 NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 W ++D PL + G ++L I +AG+Y+C+ SN +G + + L V+ P Sbjct: 2783 TWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 2842 Score = 85.1 bits (209), Expect = 3e-16 Identities = 79/296 (26%), Positives = 116/296 (39%), Gaps = 34/296 (11%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 PQ+++ +Q +G + CSA S +P +W ++++ L + ++ H+ AQG Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSA-SGYPTPH-ISWSRESQALQE---DSRIHVDAQG-- 660 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558 L ++ V G Y C +N G+ L PS + + + G Sbjct: 661 ------TLIIQGVAPEDAGNYSCQATNEVGTDQET-VTLYYTDPPSVSAVNAVVLVAVGE 713 Query: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618 A L C A G P P++ W + GG + A E I + D G Y+C A Sbjct: 714 EAVLVCEASGVPPPRVIWYR-GGLEMILAPEGS-----SSGKLRIPAAQERDAGTYTCRA 767 Query: 619 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTK-DDSPL 677 N G SA L V P D TV G +A+L C A G PPP + W + D PL Sbjct: 768 VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPL 827 Query: 678 VVTERHFFAAG---------NQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724 + AG + +L D Y CE N G + RL V Sbjct: 828 GLR----LGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879 Score = 84.3 bits (207), Expect = 5e-16 Identities = 62/223 (27%), Positives = 95/223 (42%), Gaps = 2/223 (0%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 LR++ V G Y C+ SN GS + L V P+ +P +LT+ A A L C Sbjct: 3728 LRIQPVLAQDAGHYLCLASNSAGSDRQGR-DLRVLEPPAIAPSPSNLTLTAHTPALLPCE 3786 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G P P + W KDG ++ ++P + + +D + C N G Sbjct: 3787 ASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP-QDSAQFECVVSNEVGEA 3845 Query: 626 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685 +TV P+ D TVT VL C + G P P ++W+K + L + Sbjct: 3846 HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYR 3905 Query: 686 AAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 + + L I + AG+YTC N+ G +V L+V +P Sbjct: 3906 VSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP 3948 Score = 83.2 bits (204), Expect = 1e-15 Identities = 67/245 (27%), Positives = 99/245 (40%), Gaps = 17/245 (6%) Query: 496 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLT 553 G +++ L ++ G Y C N G++ L V PS ++ Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR-DFHLLVLTPPSVLGAGAAQEVL 1419 Query: 554 IRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGV 613 AGA L+C G P PQ+ W KD P + V + V I + D G Sbjct: 1420 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPH--LQVQEDGQVLRITGSHVGDEGR 1477 Query: 614 YSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQ-------CIAGGSPPP 666 Y C A + AG + + L V P+ + GE AV++ C A G P P Sbjct: 1478 YQCVAFSPAGQQARDFQLRVHAPPTIWG-----SNETGEVAVMEDHLVQLLCEARGVPTP 1532 Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIP 726 + W KD + L + + + G + L + + SDAG YTC+ SN +G RL V Sbjct: 1533 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 1592 Query: 727 TPTCD 731 PT + Sbjct: 1593 PPTIE 1597 Score = 83.2 bits (204), Expect = 1e-15 Identities = 82/311 (26%), Positives = 121/311 (38%), Gaps = 26/311 (8%) Query: 425 AVSPDGFVCDDFP-----KPQITVQPET-QSAIKGSNLSFICSAASSSDSPMTFAWKKDN 478 A SP G DF P I ET + A+ +L + A +P W KD Sbjct: 1482 AFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP-NITWFKDG 1540 Query: 479 ELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLT 538 LL + Y +GG L+L + + G Y C SN G++ +L Sbjct: 1541 ALLPTSTKVVYT----RGGRQ------LQLGRAQSSDAGVYTCKASNAVGAAEKA-TRLD 1589 Query: 539 VNMLPSFTKT---PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVM 595 V + P+ P + AG LEC A GHP+P ++W +G P A + Sbjct: 1590 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG---LPVAESNESRLE 1646 Query: 596 PEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFL--RPLLDRTVTKGET 653 + V + G+YSC A + AG ++ V P L L T G+ Sbjct: 1647 TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQP 1706 Query: 654 AVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTL 713 L C A GSP P + W ++ P A+ L I ++ +G + C+ +N Sbjct: 1707 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 1766 Query: 714 GTERGNVRLSV 724 GT V +SV Sbjct: 1767 GTAGAEVEVSV 1777 Score = 83.2 bits (204), Expect = 1e-15 Identities = 83/320 (25%), Positives = 124/320 (38%), Gaps = 40/320 (12%) Query: 425 AVSPDGFVCDDFPKPQITVQPETQSA--------IKGSNLSFICSAASSSDSPMTFAWKK 476 A SP G +F Q+ V P + ++GS + C A P+ +W K Sbjct: 3386 AASPAGVADRNFTL-QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVP-LPLV-SWMK 3442 Query: 477 DNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAK 536 D E L +E QG L+L V G Y CV + G + + Sbjct: 3443 DGEPLLSQSLE-------QGPS-------LQLEAVGAGDSGTYSCVAVSEAGEARR-HFQ 3487 Query: 537 LTVNMLPSFTKT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHV 594 LTV P + P +L++ GA L C A G P P I W KDG R Sbjct: 3488 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATR 3547 Query: 595 MPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT--KGE 652 + +++ D G+Y+C A++ AG+I + + V P+ + P R V Sbjct: 3548 V----------LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG 3597 Query: 653 TAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712 VL+C P PK+ W +D L F + L + +D+G Y+C N Sbjct: 3598 QLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 3657 Query: 713 LGTERGNVRLSVIPTPTCDS 732 G+ R+ + PT S Sbjct: 3658 AGSTSVAFRVEIHTVPTIRS 3677 Score = 80.9 bits (198), Expect = 6e-15 Identities = 68/248 (27%), Positives = 105/248 (42%), Gaps = 13/248 (5%) Query: 483 DAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML 542 +A + H + G E ILR + E EG Y+C + G+ + KA++ V Sbjct: 464 EARLGEERHFQESGNSSWE---ILRASKAE---EGTYECTAVSRAGTGRA-KAQIVVTDP 516 Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 602 P ++T+ G A L C +G + W +D PA+ R + D Sbjct: 517 PPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRV-LPASTGRVAQLA--DLSLE 573 Query: 603 IVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGG 662 I + D G Y C A N+ G A+ L V E P + ++G + C A G Sbjct: 574 ISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASG 633 Query: 663 SPPPKLNWTKDDSPLVVTER-HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVR 721 P P ++W+++ L R H A G LII DAG Y+C+ +N +GT++ V Sbjct: 634 YPTPHISWSRESQALQEDSRIHVDAQGT--LIIQGVAPEDAGNYSCQATNEVGTDQETVT 691 Query: 722 LSVIPTPT 729 L P+ Sbjct: 692 LYYTDPPS 699 Score = 79.7 bits (195), Expect = 1e-14 Identities = 76/299 (25%), Positives = 108/299 (36%), Gaps = 21/299 (7%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P T P +S G L C AA S +P W ++ + + E GG Sbjct: 4129 PVFTTLPGDRSLRLGDRLWLRC-AARGSPTPR-IGWTVNDRPVTEGVSEQ------DGGS 4180 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR-AG 557 ++ + R G Y C N G + +V + V P + G Sbjct: 4181 TLQRAAVSR------EDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQGEAFSYLVEPVG 4233 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 +L+C G P P I W KDG P H + ++ I + +D G Y C Sbjct: 4234 GSIQLDCVVRGDPVPDIHWIKDG---LPLRGSHLRHQL-QNGSLTIHRTERDDAGRYQCL 4289 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 A+N G L + P F D TV G+ L+C A G P P + W + PL Sbjct: 4290 AENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 4349 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMT 736 + R + L + + + DAG Y C N LG+ L V P MT Sbjct: 4350 RAS-RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMT 4407 Score = 74.7 bits (182), Expect = 4e-13 Identities = 67/264 (25%), Positives = 107/264 (40%), Gaps = 27/264 (10%) Query: 496 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS-VKAKLTVNMLPSFTKTPMDL-- 552 G +V T L + VE G + C +N G++ + V+ + P + P+ Sbjct: 1735 GVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYH 1794 Query: 553 -------TIRAGAMARLECAAVGHPAPQIA--WQKDGG-----TDFPAARERRMHVMPED 598 + A + HP P + W G T P A + +P Sbjct: 1795 WGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVA-----YSLPPP 1849 Query: 599 DVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQC 658 I V + D G+Y+C A N AG L VL P+ +++ V + + L+C Sbjct: 1850 --LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLEC 1907 Query: 659 IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTE-- 716 +A G PPP ++W K P+ + ++L I + +SDAG Y C SN G+ Sbjct: 1908 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 1967 Query: 717 RGNVRLSVIPTPTCDSPQMTAPSL 740 R +R++V P T P + P L Sbjct: 1968 RYGLRVNVPPRITL-PPSLPGPVL 1990 Score = 72.4 bits (176), Expect = 2e-12 Identities = 58/228 (25%), Positives = 93/228 (40%), Gaps = 21/228 (9%) Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLTIR 555 +V E +LR+ EG+YQCV + G + +L V+ P+ + ++ + Sbjct: 1457 QVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVM 1515 Query: 556 AGAMARLECAAVGHPAPQIAWQKDGG-----TDFPAARERRMHVMPEDDVFFIVDVKIED 610 + +L C A G P P I W KDG T R R + + D Sbjct: 1516 EDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGR--------AQSSD 1567 Query: 611 IGVYSCTAQNSAGSISANATLTVLETPSFL----RPLLDRTVTKGETAVLQCIAGGSPPP 666 GVY+C A N+ G+ L V P+ RP + + V G L+C+A G P P Sbjct: 1568 AGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA-GRPVALECVARGHPSP 1626 Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714 L+W + P+ + +L + + +G Y+C S+ G Sbjct: 1627 TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG 1674 Score = 72.0 bits (175), Expect = 3e-12 Identities = 73/296 (24%), Positives = 114/296 (38%), Gaps = 41/296 (13%) Query: 469 PMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFG 528 P T W KD + + + +V+ +L+++ + + G+Y CV +N G Sbjct: 2668 PPTIRWYKDGQPVTPSSRL----------QVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 2717 Query: 529 SSYSVKAKLTVNMLPSFTKT----------PMDLTIRAGAM----------ARLECAAVG 568 + + + P F K + R G A L C Sbjct: 2718 ED-DQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNA 2776 Query: 569 HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628 P P + W ++ D P + + V+ V I V+ E+ G YSC A N G + Sbjct: 2777 IPPPDLTWYRE---DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 2833 Query: 629 ATLTVLETPSFL---RPLLDR-TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHF 684 L VL P L L++ TV T LQC A G+P P ++W ++ P + R Sbjct: 2834 YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQ 2893 Query: 685 FAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT---CDSPQMTA 737 Q+L + ++V+DA Y C N G+ L V P D Q+TA Sbjct: 2894 VLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 2949 >gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3783 Score = 120 bits (301), Expect = 7e-27 Identities = 86/291 (29%), Positives = 129/291 (44%), Gaps = 15/291 (5%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P I P ++ ++ ++++ C A S P +W K ++ + G Sbjct: 604 PNIEPGPVNKAVLENASVTLECLA--SGVPPPDVSWFKGHQPVSSW----------MGVT 651 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-MDLTIRAG 557 V +LR+ + + + G Y+CV SN GS+ ++ L VN+ P T P + + Sbjct: 652 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGST-ELRYGLRVNVPPRITLPPSLPGPVLVN 710 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 RL C A G P+P + W KDG PA + V P V + + D G YSC Sbjct: 711 TPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG-LQVFPGGRVLTLASARASDSGRYSCV 769 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 A ++ G + L V PS L L+ +V E+ L+C + PPP L+W KD PL Sbjct: 770 AVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL 829 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 +A LL + +DV DAG YTCE N G + L+V P Sbjct: 830 EPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP 880 Score = 114 bits (285), Expect = 5e-25 Identities = 77/269 (28%), Positives = 120/269 (44%), Gaps = 18/269 (6%) Query: 473 AWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS 532 +W+KD + L E H+ A G +L L + + A EG Y C SN G+S S Sbjct: 913 SWRKDGQPL-PGEGAGLQHVSAVG-------RLLYLGQAQLAQEGTYTCECSNVVGNS-S 963 Query: 533 VKAKLTVNMLPSFT---KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARE 589 +L V++ P + P +++ +A LEC A G P P + W++DG P E Sbjct: 964 QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ---PVGAE 1020 Query: 590 RRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF---LRPLLDR 646 + + + + + G YSC A+N AG L+VL P L PL + Sbjct: 1021 LGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI 1080 Query: 647 TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYT 706 T L C A G PPP + W + + P+ E + AG +L + + D+G Y+ Sbjct: 1081 TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYS 1140 Query: 707 CEMSNTLGTERGNVRLSVIPTPTCDSPQM 735 C SN G R N + V+ P+ ++ + Sbjct: 1141 CLASNEAGEARRNFSVEVLVPPSIENEDL 1169 Score = 107 bits (268), Expect = 5e-23 Identities = 75/255 (29%), Positives = 113/255 (44%), Gaps = 24/255 (9%) Query: 505 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML--PSFTKTPMDLTIRA--GAMA 560 +L++ + + G Y C+ SN G + + +V +L PS ++ I+ G A Sbjct: 1125 MLKMTQTQEQDSGLYSCLASNEAGEA---RRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 1181 Query: 561 RLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQN 620 L C GHP P++ W KDG P AR H+ P+ + ++ + G YSC A N Sbjct: 1182 HLMCNVTGHPQPKLTWFKDGR---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1238 Query: 621 SAGSISANATLTVLETPSFLRPLLDR-----TVTKGETAVLQCIAGGSPPPKLNWTKDDS 675 + G + + L+VL P+ L D TVT L C A P P + W KD + Sbjct: 1239 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1298 Query: 676 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 735 P + G L I+++ DAG+YTC ++N LG N + V+ P+ Sbjct: 1299 PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--- 1355 Query: 736 TAPSLDDDGWATVGV 750 DD A VGV Sbjct: 1356 ------DDPLAEVGV 1364 Score = 106 bits (265), Expect = 1e-22 Identities = 83/292 (28%), Positives = 133/292 (45%), Gaps = 22/292 (7%) Query: 444 QPETQ-SAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEY 502 +P TQ S ++ + C+A P T W++D + + AE+ G ++ Sbjct: 981 EPPTQVSVVQDGVATLECNATGKP--PPTVTWERDGQPV-GAEL---------GLQLQNQ 1028 Query: 503 TTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAM--- 559 L + + A G+Y CV N G + K +L+V + P LT A+ Sbjct: 1029 GQSLHVERAQAAHTGRYSCVAENLAGRAER-KFELSVLVPPELIGDLDPLTNITAALHSP 1087 Query: 560 ARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQ 619 L C A+G P P I W + + P + +++ + + + +D G+YSC A Sbjct: 1088 LTLLCEAMGIPPPAIRWFRG---EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 1144 Query: 620 NSAGSISANATLTVLETPSFLRPLLDRT--VTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 N AG N ++ VL PS L+ V G+TA L C G P PKL W KD PL Sbjct: 1145 NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1204 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 + H + LL ++ +++S AG Y+C +N +G + + +LSV+ PT Sbjct: 1205 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT 1256 Score = 106 bits (265), Expect = 1e-22 Identities = 71/242 (29%), Positives = 111/242 (45%), Gaps = 9/242 (3%) Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD-LTIRA 556 +V+E +L++ E A Y CV N GS+ + L V + P ++ +T Sbjct: 1611 QVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT-LRVQVPPRIAGLDLEQVTAIL 1669 Query: 557 GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616 + L C HP P++ W KD + + ++P + ++ D G+Y+C Sbjct: 1670 NSSVSLPCDVHAHPNPEVTWYKDSQA---LSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 1726 Query: 617 TAQNSAGSISANATLTVLETPSFLR----PLLDRTVTKGETAVLQCIAGGSPPPKLNWTK 672 A N+AG L+VL P+F + P V G+ AVL C P P + W K Sbjct: 1727 EALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK 1786 Query: 673 DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732 D PLV+ +R G Q L I ++ VSD G Y+C++SN G L+V PT ++ Sbjct: 1787 DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFEN 1846 Query: 733 PQ 734 P+ Sbjct: 1847 PK 1848 Score = 105 bits (261), Expect = 3e-22 Identities = 122/478 (25%), Positives = 184/478 (38%), Gaps = 75/478 (15%) Query: 386 LLCDCQLKWLPQ--WVAENNFQSFVNASCAHPQLLKGR-----SIFAVSPDGFVCDDF-- 436 LLCD Q P W + + + + ++L+ R + A SP G + F Sbjct: 2233 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 2292 Query: 437 --PKPQITVQPETQSAIKG---SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAH 491 P V P + G L CS + +T W +D +L + AH Sbjct: 2293 RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT--WHRDGIVLQED-----AH 2345 Query: 492 LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD 551 + E L+L+ + A G Y C N GS+ SV ++ ++ +P+ P Sbjct: 2346 T-----QFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTVPTIRSGPPA 2399 Query: 552 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611 + + A L C A G PAP ++W+KD P R R ++PE + I V +D Sbjct: 2400 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP--RSPRFEILPEGSLR-IQPVLAQDA 2456 Query: 612 GVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWT 671 G Y C A NSAGS L VLE P+ + T+T A+L C A GSP P + W Sbjct: 2457 GHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWW 2516 Query: 672 KDDSPL--VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 KD L + + + + L++ D+ ++ C +SN +G +++V PT Sbjct: 2517 KDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2576 Query: 730 CDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETN 789 DD TV ++ V+ C T Sbjct: 2577 I---------ADDQTDFTVTMMAPVVLTC---------------------------HSTG 2600 Query: 790 LPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSS 847 +PA S+ + L R GY S SG+ G LP H TC NS+ Sbjct: 2601 IPAPTVSWSKAGAQLGARGSGYRVSPSGALE-------IGQALPIHAGRYTCSARNSA 2651 Score = 104 bits (260), Expect = 4e-22 Identities = 67/209 (32%), Positives = 97/209 (46%), Gaps = 6/209 (2%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 LR+ G Y C+ N GS+ K +L V + P DL+ G+ A L C Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMG-KTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2778 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G P P I W KDG + E + + P ++ + +++ +D G Y+CTA+N+ G Sbjct: 2779 ARGSPEPNITWDKDGQP--VSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRA 2835 Query: 626 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685 LT+L P F DR++ G+ L+C A GSP P++ WT +D P VTE Sbjct: 2836 RRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP--VTEGVSE 2893 Query: 686 AAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714 G L D+G Y C N +G Sbjct: 2894 QDGGSTLQRAAVSREDSGTYVCWAENRVG 2922 Score = 104 bits (259), Expect = 5e-22 Identities = 71/212 (33%), Positives = 92/212 (43%), Gaps = 5/212 (2%) Query: 517 GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 576 G+Y C N G ++ LTV P P + A L C A G P P I W Sbjct: 2641 GRYTCSARNSAGVAHK-HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW 2699 Query: 577 QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET 636 QK+G A V+P + I ED G Y C A+NSAGS L V Sbjct: 2700 QKEG---LNVATGVSTQVLPGGQLR-IAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVP 2755 Query: 637 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVD 696 P L D + T+G A L C A GSP P + W KD P+ E F + L++ + Sbjct: 2756 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKN 2815 Query: 697 SDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 + DAG YTC N +G R V L+++ P Sbjct: 2816 LEGQDAGTYTCTAENAVGRARRRVHLTILVLP 2847 Score = 93.2 bits (230), Expect = 1e-18 Identities = 83/294 (28%), Positives = 125/294 (42%), Gaps = 25/294 (8%) Query: 446 ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 505 ET S + GS L C S +P T W KD + + + ++GG Sbjct: 1850 ETVSQVAGSPLVLTCDV-SGVPAP-TVTWLKDRMPVESSAVHGVV---SRGGR------- 1897 Query: 506 LRLREVEFASEGKYQCVISNHFGSSYS--VKAKLTVNMLPSFTKTPMDLTIRAGAMARLE 563 L+L ++ A G Y CV N + V A L + S + + + G RL+ Sbjct: 1898 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS-SGVAREHHVLEGQEVRLD 1956 Query: 564 CAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIV--DVKIEDIGVYSCTAQNS 621 C A G P P +AW KDG P ++ H+ D +V ++ D G Y+C A N Sbjct: 1957 CEADGQPPPDVAWLKDGS---PLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNP 2013 Query: 622 AGSISANATLTVLETPSFLRPLLDRTVT----KGETAVLQCIAGGSPPPKLNWTKDDSPL 677 AG + T+ VL P+ ++ D + T GE + C GSPP ++W KD PL Sbjct: 2014 AGEDARLHTVNVLVPPT-IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL 2072 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCD 731 +++R L I ++DAG +TC ++ G N L V P + Sbjct: 2073 PLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE 2126 Score = 92.4 bits (228), Expect = 2e-18 Identities = 69/227 (30%), Positives = 101/227 (44%), Gaps = 7/227 (3%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 L++ +V+ EG Y C +N G S A L V + P+ P++ + A LEC Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECL 626 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G P P ++W K P + + V + V I ++ D G Y C A N AGS Sbjct: 627 ASGVPPPDVSWFKGHQ---PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 683 Query: 626 SANATLTVLETPSF-LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL--VVTER 682 L V P L P L V L C A G+P P L W KD +P+ T Sbjct: 684 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 743 Query: 683 HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729 G ++L + + SD+G+Y+C + +G +R +V L V P+ Sbjct: 744 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 790 Score = 92.0 bits (227), Expect = 3e-18 Identities = 77/294 (26%), Positives = 113/294 (38%), Gaps = 18/294 (6%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P I + S + +++ C S + P +W KD L E HL A Sbjct: 789 PSILGEELNVSVVANESVALECQ--SHAMPPPVLSWWKDGRPL---EPRPGVHLSAD--- 840 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT-KTPMDLTIRAG 557 +L++ + G Y C N G S L V + P F + LT+R G Sbjct: 841 ----KALLQVDRADVWDAGHYTCEALNQAGHSEK-HYNLNVWVAPVFPLRESHTLTVREG 895 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 RL C G P P+I+W+KD G P HV + ++ ++ G Y+C Sbjct: 896 HPTRLSCECRGVPFPKISWRKD-GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 954 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRT---VTKGETAVLQCIAGGSPPPKLNWTKDD 674 N G+ S + L V P P T V + A L+C A G PPP + W +D Sbjct: 955 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDG 1014 Query: 675 SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 P+ Q L + + + G+Y+C N G LSV+ P Sbjct: 1015 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP 1068 Score = 90.9 bits (224), Expect = 6e-18 Identities = 78/272 (28%), Positives = 120/272 (44%), Gaps = 18/272 (6%) Query: 463 ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 522 AS S P+ WK +L D ++ QG + + L L +++CV Sbjct: 2505 ASGSPKPLVVWWKDGQKL--DFRLQ-------QGAYRLLPSNALLLTAPGPQDSAQFECV 2555 Query: 523 ISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGT 582 +SN G ++ + ++TV++ P+ D T+ A L C + G PAP ++W K G Sbjct: 2556 VSNEVGEAHRLY-QVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 2614 Query: 583 DFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRP 642 AR V P + + I G Y+C+A+NSAG + LTV +P ++P Sbjct: 2615 --LGARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFLTVQASP-VVKP 2670 Query: 643 L--LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS 700 L + R V + E +L C A G P P + W K+ + G QL I + Sbjct: 2671 LPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRI-AHASPE 2728 Query: 701 DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732 DAG Y C N+ G+ G RL V P ++ Sbjct: 2729 DAGNYLCIAKNSAGSAMGKTRLVVQVPPVIEN 2760 Score = 86.3 bits (212), Expect = 1e-16 Identities = 74/300 (24%), Positives = 120/300 (40%), Gaps = 43/300 (14%) Query: 456 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515 +S IC A + +T W KD A E +++ G T L++ + Sbjct: 1277 ISLICEALAFPSPNIT--WMKDG-----APFEASRNIQLLPG-----THGLQILNAQKED 1324 Query: 516 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-------MDLTIRAGAMARLECAAVG 568 G+Y CV++N G + + V + PS +K ++ + + LEC + Sbjct: 1325 AGQYTCVVTNELGEAVK-NYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWA 1383 Query: 569 HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628 P P I W KDG P R+ V+ E + I ++ D G Y C A N AG + Sbjct: 1384 VPPPTIRWYKDGQ---PVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD 1440 Query: 629 ATLTVLETPSFLR--------PLLDRT------------VTKGETAVLQCIAGGSPPPKL 668 + + P F + +L R + + A L C PPP L Sbjct: 1441 FNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL 1500 Query: 669 NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 W ++D PL + G ++L I +AG+Y+C+ SN +G + + L V+ P Sbjct: 1501 TWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 1560 Score = 84.3 bits (207), Expect = 5e-16 Identities = 62/223 (27%), Positives = 95/223 (42%), Gaps = 2/223 (0%) Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565 LR++ V G Y C+ SN GS + L V P+ +P +LT+ A A L C Sbjct: 2446 LRIQPVLAQDAGHYLCLASNSAGSDRQGR-DLRVLEPPAIAPSPSNLTLTAHTPALLPCE 2504 Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625 A G P P + W KDG ++ ++P + + +D + C N G Sbjct: 2505 ASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP-QDSAQFECVVSNEVGEA 2563 Query: 626 SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685 +TV P+ D TVT VL C + G P P ++W+K + L + Sbjct: 2564 HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYR 2623 Query: 686 AAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728 + + L I + AG+YTC N+ G +V L+V +P Sbjct: 2624 VSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP 2666 Score = 83.2 bits (204), Expect = 1e-15 Identities = 67/245 (27%), Positives = 99/245 (40%), Gaps = 17/245 (6%) Query: 496 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLT 553 G +++ L ++ G Y C N G++ L V PS ++ Sbjct: 79 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR-DFHLLVLTPPSVLGAGAAQEVL 137 Query: 554 IRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGV 613 AGA L+C G P PQ+ W KD P + V + V I + D G Sbjct: 138 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPH--LQVQEDGQVLRITGSHVGDEGR 195 Query: 614 YSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQ-------CIAGGSPPP 666 Y C A + AG + + L V P+ + GE AV++ C A G P P Sbjct: 196 YQCVAFSPAGQQARDFQLRVHAPPTIWG-----SNETGEVAVMEDHLVQLLCEARGVPTP 250 Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIP 726 + W KD + L + + + G + L + + SDAG YTC+ SN +G RL V Sbjct: 251 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 310 Query: 727 TPTCD 731 PT + Sbjct: 311 PPTIE 315 Score = 83.2 bits (204), Expect = 1e-15 Identities = 82/311 (26%), Positives = 121/311 (38%), Gaps = 26/311 (8%) Query: 425 AVSPDGFVCDDFP-----KPQITVQPET-QSAIKGSNLSFICSAASSSDSPMTFAWKKDN 478 A SP G DF P I ET + A+ +L + A +P W KD Sbjct: 200 AFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP-NITWFKDG 258 Query: 479 ELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLT 538 LL + Y +GG L+L + + G Y C SN G++ +L Sbjct: 259 ALLPTSTKVVYT----RGGRQ------LQLGRAQSSDAGVYTCKASNAVGAAEKA-TRLD 307 Query: 539 VNMLPSFTKT---PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVM 595 V + P+ P + AG LEC A GHP+P ++W +G P A + Sbjct: 308 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG---LPVAESNESRLE 364 Query: 596 PEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFL--RPLLDRTVTKGET 653 + V + G+YSC A + AG ++ V P L L T G+ Sbjct: 365 TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQP 424 Query: 654 AVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTL 713 L C A GSP P + W ++ P A+ L I ++ +G + C+ +N Sbjct: 425 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 484 Query: 714 GTERGNVRLSV 724 GT V +SV Sbjct: 485 GTAGAEVEVSV 495 Score = 83.2 bits (204), Expect = 1e-15 Identities = 83/320 (25%), Positives = 124/320 (38%), Gaps = 40/320 (12%) Query: 425 AVSPDGFVCDDFPKPQITVQPETQSA--------IKGSNLSFICSAASSSDSPMTFAWKK 476 A SP G +F Q+ V P + ++GS + C A P+ +W K Sbjct: 2104 AASPAGVADRNFTL-QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVP-LPLV-SWMK 2160 Query: 477 DNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAK 536 D E L +E QG L+L V G Y CV + G + + Sbjct: 2161 DGEPLLSQSLE-------QGPS-------LQLEAVGAGDSGTYSCVAVSEAGEARR-HFQ 2205 Query: 537 LTVNMLPSFTKT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHV 594 LTV P + P +L++ GA L C A G P P I W KDG R Sbjct: 2206 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATR 2265 Query: 595 MPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT--KGE 652 + +++ D G+Y+C A++ AG+I + + V P+ + P R V Sbjct: 2266 V----------LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG 2315 Query: 653 TAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712 VL+C P PK+ W +D L F + L + +D+G Y+C N Sbjct: 2316 QLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 2375 Query: 713 LGTERGNVRLSVIPTPTCDS 732 G+ R+ + PT S Sbjct: 2376 AGSTSVAFRVEIHTVPTIRS 2395 Score = 82.8 bits (203), Expect = 2e-15 Identities = 59/189 (31%), Positives = 80/189 (42%), Gaps = 15/189 (7%) Query: 556 AGAMARLECAAVGHPAPQIAWQKDG------------GTDFPAARERRMHVMPEDDVFFI 603 AG LEC A G P P+I W KD G D + ++ E Sbjct: 32 AGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHF 91 Query: 604 VDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTV--TKGETAVLQCIAG 661 ++ D G+YSC A+N AG+ + L VL PS L + V G LQC Sbjct: 92 PRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTS 151 Query: 662 GSPPPKLNWTKDDSPLVVTERHF-FAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV 720 G P P++ WTKD P++ H Q+L I S V D G+Y C + G + + Sbjct: 152 GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDF 211 Query: 721 RLSVIPTPT 729 +L V PT Sbjct: 212 QLRVHAPPT 220 Score = 79.7 bits (195), Expect = 1e-14 Identities = 76/299 (25%), Positives = 108/299 (36%), Gaps = 21/299 (7%) Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498 P T P +S G L C AA S +P W ++ + + E GG Sbjct: 2847 PVFTTLPGDRSLRLGDRLWLRC-AARGSPTPR-IGWTVNDRPVTEGVSEQ------DGGS 2898 Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR-AG 557 ++ + R G Y C N G + +V + V P + G Sbjct: 2899 TLQRAAVSR------EDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQGEAFSYLVEPVG 2951 Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617 +L+C G P P I W KDG P H + ++ I + +D G Y C Sbjct: 2952 GSIQLDCVVRGDPVPDIHWIKDG---LPLRGSHLRHQL-QNGSLTIRRTERDDAGRYQCL 3007 Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677 A+N G L + P F D TV G+ L+C A G P P + W + PL Sbjct: 3008 AENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3067 Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMT 736 + R + L + + + DAG Y C N LG+ L V P MT Sbjct: 3068 RAS-RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMT 3125 Score = 74.7 bits (182), Expect = 4e-13 Identities = 67/264 (25%), Positives = 107/264 (40%), Gaps = 27/264 (10%) Query: 496 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS-VKAKLTVNMLPSFTKTPMDL-- 552 G +V T L + VE G + C +N G++ + V+ + P + P+ Sbjct: 453 GVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYH 512 Query: 553 -------TIRAGAMARLECAAVGHPAPQIA--WQKDGG-----TDFPAARERRMHVMPED 598 + A + HP P + W G T P A + +P Sbjct: 513 WGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVA-----YSLPPP 567 Query: 599 DVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQC 658 I V + D G+Y+C A N AG L VL P+ +++ V + + L+C Sbjct: 568 --LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLEC 625 Query: 659 IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTE-- 716 +A G PPP ++W K P+ + ++L I + +SDAG Y C SN G+ Sbjct: 626 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 685 Query: 717 RGNVRLSVIPTPTCDSPQMTAPSL 740 R +R++V P T P + P L Sbjct: 686 RYGLRVNVPPRITL-PPSLPGPVL 708 Score = 72.4 bits (176), Expect = 2e-12 Identities = 58/228 (25%), Positives = 93/228 (40%), Gaps = 21/228 (9%) Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLTIR 555 +V E +LR+ EG+YQCV + G + +L V+ P+ + ++ + Sbjct: 175 QVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVM 233 Query: 556 AGAMARLECAAVGHPAPQIAWQKDGG-----TDFPAARERRMHVMPEDDVFFIVDVKIED 610 + +L C A G P P I W KDG T R R + + D Sbjct: 234 EDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGR--------AQSSD 285 Query: 611 IGVYSCTAQNSAGSISANATLTVLETPSFL----RPLLDRTVTKGETAVLQCIAGGSPPP 666 GVY+C A N+ G+ L V P+ RP + + V G L+C+A G P P Sbjct: 286 AGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA-GRPVALECVARGHPSP 344 Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714 L+W + P+ + +L + + +G Y+C S+ G Sbjct: 345 TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG 392 Score = 72.4 bits (176), Expect = 2e-12 Identities = 81/333 (24%), Positives = 131/333 (39%), Gaps = 45/333 (13%) Query: 432 VCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAH 491 + D P ++ V+ E ++ + S L+ C S + P T W KD + + + Sbjct: 1353 ISKDDPLAEVGVK-EVKTKVN-STLTLECE--SWAVPPPTIRWYKDGQPVTPSSRL---- 1404 Query: 492 LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT--- 548 +V+ +L+++ + + G+Y CV +N G + + + P F K Sbjct: 1405 ------QVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNVLIQVPPMFQKVGDF 1457 Query: 549 -------PMDLTIRAGAM----------ARLECAAVGHPAPQIAWQKDGGTDFPAARERR 591 + R G A L C P P + W ++ D P + Sbjct: 1458 SAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE---DQPLSAGDE 1514 Query: 592 MHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFL---RPLLDR-T 647 + V+ V I V+ E+ G YSC A N G + L VL P L L++ T Sbjct: 1515 VSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVT 1574 Query: 648 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTC 707 V T LQC A G+P P ++W ++ P + R Q+L + ++V+DA Y C Sbjct: 1575 VNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMC 1634 Query: 708 EMSNTLGTERGNVRLSVIPTPT---CDSPQMTA 737 N G+ L V P D Q+TA Sbjct: 1635 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1667 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.133 0.396 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 41,463,178 Number of Sequences: 37866 Number of extensions: 1928290 Number of successful extensions: 13996 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 421 Number of HSP's successfully gapped in prelim test: 264 Number of HSP's that attempted gapping in prelim test: 4894 Number of HSP's gapped (non-prelim): 3986 length of query: 1059 length of database: 18,247,518 effective HSP length: 113 effective length of query: 946 effective length of database: 13,968,660 effective search space: 13214352360 effective search space used: 13214352360 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.