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Search of human proteins with 205277423
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|205277423 immunoglobulin superfamily, member 9 isoform b
[Homo sapiens]
(1163 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|205277423 immunoglobulin superfamily, member 9 isoform b [Hom... 2379 0.0
gi|205277425 immunoglobulin superfamily, member 9 isoform a [Hom... 2365 0.0
gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens] 733 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 135 2e-31
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 134 5e-31
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 134 5e-31
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 130 9e-30
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 125 3e-28
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 125 3e-28
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 125 3e-28
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 124 5e-28
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 122 2e-27
gi|222352127 sidekick 2 [Homo sapiens] 120 1e-26
gi|157311649 neogenin homolog 1 [Homo sapiens] 120 1e-26
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 117 5e-26
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 117 5e-26
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 117 5e-26
gi|109150416 peroxidasin [Homo sapiens] 117 5e-26
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 115 2e-25
gi|83281200 protogenin [Homo sapiens] 115 2e-25
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 115 2e-25
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 113 1e-24
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 111 5e-24
gi|19743806 roundabout 1 isoform b [Homo sapiens] 110 6e-24
gi|4506569 roundabout 1 isoform a [Homo sapiens] 110 6e-24
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 110 6e-24
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 110 8e-24
gi|224994173 roundabout 1 isoform d [Homo sapiens] 108 3e-23
gi|224994171 roundabout 1 isoform c [Homo sapiens] 108 3e-23
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 108 3e-23
>gi|205277423 immunoglobulin superfamily, member 9 isoform b [Homo
sapiens]
Length = 1163
Score = 2379 bits (6166), Expect = 0.0
Identities = 1163/1163 (100%), Positives = 1163/1163 (100%)
Query: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60
MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF
Sbjct: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60
Query: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120
GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED
Sbjct: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120
Query: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180
DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG
Sbjct: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180
Query: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240
QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA
Sbjct: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240
Query: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300
SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT
Sbjct: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300
Query: 301 CVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT 360
CVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT
Sbjct: 301 CVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGT 360
Query: 361 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420
EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL
Sbjct: 361 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420
Query: 421 LIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA 480
LIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA
Sbjct: 421 LIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA 480
Query: 481 TSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD 540
TSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD
Sbjct: 481 TSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD 540
Query: 541 WVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLP 600
WVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLP
Sbjct: 541 WVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLP 600
Query: 601 PTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAG 660
PTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAG
Sbjct: 601 PTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAG 660
Query: 661 TETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVL 720
TETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVL
Sbjct: 661 TETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVL 720
Query: 721 AGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSG 780
AGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSG
Sbjct: 721 AGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSG 780
Query: 781 SPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMG 840
SPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMG
Sbjct: 781 SPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMG 840
Query: 841 PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSP 900
PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSP
Sbjct: 841 PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSP 900
Query: 901 LPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVS 960
LPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVS
Sbjct: 901 LPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVS 960
Query: 961 PRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRP 1020
PRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRP
Sbjct: 961 PRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRP 1020
Query: 1021 PSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDM 1080
PSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDM
Sbjct: 1021 PSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDM 1080
Query: 1081 ELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRR 1140
ELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRR
Sbjct: 1081 ELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRR 1140
Query: 1141 DATRARLPAYRQPVPHPEQATLL 1163
DATRARLPAYRQPVPHPEQATLL
Sbjct: 1141 DATRARLPAYRQPVPHPEQATLL 1163
>gi|205277425 immunoglobulin superfamily, member 9 isoform a [Homo
sapiens]
Length = 1179
Score = 2365 bits (6128), Expect = 0.0
Identities = 1162/1179 (98%), Positives = 1162/1179 (98%), Gaps = 16/1179 (1%)
Query: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60
MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF
Sbjct: 1 MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF 60
Query: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120
GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED
Sbjct: 61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPED 120
Query: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180
DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG
Sbjct: 121 DFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG 180
Query: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240
QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA
Sbjct: 181 QGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA 240
Query: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300
SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT
Sbjct: 241 SQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYT 300
Query: 301 CVPSNGLLHPPSASAYLTVLC----------------MPGVIRCPVRANPPLLFVSWTKD 344
CVPSNGLLHPPSASAYLTVL MPGVIRCPVRANPPLLFVSWTKD
Sbjct: 301 CVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKD 360
Query: 345 GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 404
GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF
Sbjct: 361 GKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF 420
Query: 405 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA 464
IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA
Sbjct: 421 IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA 480
Query: 465 HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS 524
HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS
Sbjct: 481 HGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFS 540
Query: 525 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 584
VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL
Sbjct: 541 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 600
Query: 585 SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG 644
SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG
Sbjct: 601 SAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEG 660
Query: 645 RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 704
RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV
Sbjct: 661 RQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEV 720
Query: 705 YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI 764
YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI
Sbjct: 721 YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLI 780
Query: 765 FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL 824
FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL
Sbjct: 781 FSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPL 840
Query: 825 PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI 884
PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI
Sbjct: 841 PLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCI 900
Query: 885 EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 944
EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR
Sbjct: 901 EDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 960
Query: 945 CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS 1004
CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS
Sbjct: 961 CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS 1020
Query: 1005 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT 1064
LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT
Sbjct: 1021 LTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNT 1080
Query: 1065 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA 1124
SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA
Sbjct: 1081 SVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEA 1140
Query: 1125 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL 1163
RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL
Sbjct: 1141 RCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL 1179
>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
Length = 1349
Score = 733 bits (1891), Expect = 0.0
Identities = 437/1026 (42%), Positives = 568/1026 (55%), Gaps = 85/1026 (8%)
Query: 1 MVWCLGLAVLSLVISQGADGRG----KPEVVSVVGRAGESVVLGCDLLPPA-GRPPLHVI 55
M+W + + S++ ++G G + E V RAGESVVL CD++ P G+PP +V+
Sbjct: 1 MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV 60
Query: 56 EWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ 115
EW +FG +PIFI+FG Y P +DP+Y GR L ASL++E +R EDQGWYEC+V LDQ
Sbjct: 61 EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ 120
Query: 116 HIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGK 175
D F NGSWVHLT+N+PP F ETPP +E +E +T+ C A G+P P VTW G
Sbjct: 121 QY--DTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGT 178
Query: 176 DLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKN 235
LG G+ QV +G+L + V R G YTC+A S +G A H T LLV GPP IV PP+N
Sbjct: 179 LLG-ASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPEN 237
Query: 236 STVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDD 295
TVN SQD L C AEAYP NLTY+W+ + NV+ + L+ RVRIL+DG+L + +P+D
Sbjct: 238 ITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPED 297
Query: 296 AGCYTCVPSNGLLHPPSASAYLTV------LCMP----------GVIRCPVRANPPLLFV 339
+G YTCVPSN L PSASAYLTV L MP G IRCPV A PP V
Sbjct: 298 SGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVV 357
Query: 340 SWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 399
W KDG+ LQ++K GW+ +GS+ I E+ALG Y+C PYN+LGT G S R++LK
Sbjct: 358 KWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLK 417
Query: 400 APPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRP 459
PP F P EY QE GRELLIPC+A GDP PV++W KVG+ + + + SL R
Sbjct: 418 DPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRA 477
Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGY 519
L+KE HG WEC A+N V + ST++ V+GTSPH +V V ANVSWEPG+DGGY
Sbjct: 478 LSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGY 537
Query: 520 LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPF 579
Q FSVW KR HDW+SL VP G + LLV L+P T YQFSVLAQNKLG+ F
Sbjct: 538 EQTFSVW----MKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAF 593
Query: 580 SEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDG 639
SE+V P T P + T PPR L+A RT +GVLL W PP +D
Sbjct: 594 SEVVTVNTLAFPITTPEPLVLVT-------PPRCLIANRTQQGVLLSWLPPANHSFPIDR 646
Query: 640 YVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVST 699
Y++E R ++ WE+LD + GTE E L +D YEFR++A +S+PSN A VS+
Sbjct: 647 YIMEFRV-AERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSS 705
Query: 700 SGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQ 759
+ +++P L +PVLAG+V +CFL A+L S LA C +N++R + +RK+
Sbjct: 706 T--DIFPQPDLTEDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKK--- 760
Query: 760 DPPLIFSPTGKS-AAPSALGSGSPDSVAKLKL-------QGSPVP------------SLR 799
DPPL + KS +P + G SP+S+ L+ QG P SL
Sbjct: 761 DPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLY 820
Query: 800 QSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRT 859
+ + S + P+E I RGPDGRFVM P P +S R + P
Sbjct: 821 KKTKRAISSKKYSVAKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFA 880
Query: 860 PAQRLARSFDCSSSSPSGAPQPLCI----EDISPVA-------PPPA----APPSPLPGP 904
+ F S P + ++P++ PPPA P L GP
Sbjct: 881 EETDMYPEFRQSDEENEDPLVPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGP 940
Query: 905 GPLLQYLSL------PFFREMNVDGDWPPLEEPSPA---APPDYMDTRRCPTSSFLRSPE 955
G L L P R + + L SP PP Y+ P SS + SP
Sbjct: 941 GGLEGRLQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPP 1000
Query: 956 TPPVSP 961
P P
Sbjct: 1001 LPTEGP 1006
Score = 35.4 bits (80), Expect = 0.32
Identities = 81/314 (25%), Positives = 105/314 (33%), Gaps = 56/314 (17%)
Query: 777 LGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSP--HPDPPSSRGP------LPLEP 828
L S SP V V S S++ P T P HP P G LPL
Sbjct: 970 LSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENASNSTLPLTQ 1029
Query: 829 ICRG-----PDGR--FVMG----PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS-PS 876
G P GR F G P + P + + E P L R +S P+
Sbjct: 1030 TPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGLPPTSLQVPA 1089
Query: 877 GAPQPLCIE------DISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEE 930
P L +E SP P APP+ P+ +S R + P L
Sbjct: 1090 AYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPY 1149
Query: 931 PSPAAPPDY-------MDTRRCPTSSFLRSPETPPVSPRE------SLPGAVVGAGATAE 977
P PA P + +DTR + P SPR+ SL V+ +
Sbjct: 1150 PEPAEPGAHGGPSTFGLDTR------WYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSP 1203
Query: 978 PPYTALADWT------LRERLLPGLLPAAPRGSLTSQ-----SSGRGSASFLRPPSTAPS 1026
+ L+ T R R PGLL A +T Q S R S PS +
Sbjct: 1204 LTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSR 1263
Query: 1027 AGGSYLSPAPGDTS 1040
+G PA G T+
Sbjct: 1264 SGSPSYRPAMGFTT 1277
Score = 33.1 bits (74), Expect = 1.6
Identities = 77/307 (25%), Positives = 107/307 (34%), Gaps = 50/307 (16%)
Query: 599 LPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPE--LVPKRLDGYV-LEGRQGSQG----- 650
LPP ++P L P GL PRG+ PP VP G + LE +G G
Sbjct: 1061 LPPCDVPESLQPKAGL-----PRGL-----PPTSLQVPAAYPGILSLEAPKGWAGKSPGR 1110
Query: 651 WEVLDPAVAGTETELLVP----GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYP 706
V P A + + P G ++ + ++P ST GL+
Sbjct: 1111 GPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPYPEPAEPGAHGGPSTFGLD--- 1167
Query: 707 SRTQLPGLLPQPVLAGVVGGVCFLGVAVL----VSILAGCLLNRRRAARRRRKRLRQDPP 762
+R P P+P L VL +S L L+ R + R R P
Sbjct: 1168 TRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPG 1227
Query: 763 LIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTP--------SPH 814
L+ + A S + P +V+ + S QS G P+ P + +
Sbjct: 1228 LL-----QQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSRSGSPSYRPAMGFTTLATGY 1282
Query: 815 PDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSS 874
P PP GP P P D V G T + R+G E P TP L S
Sbjct: 1283 PSPPP--GPAPAGP----GDSLDVFGQTPS--PRRTGEELLRPETPPPTLPTSGKLQRDR 1334
Query: 875 PSGAPQP 881
P+ A P
Sbjct: 1335 PAPATSP 1341
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 135 bits (341), Expect = 2e-31
Identities = 135/509 (26%), Positives = 214/509 (42%), Gaps = 61/509 (11%)
Query: 20 GRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDP 79
G +P ++V+ ++ D +PP VI WLR G L +PR+
Sbjct: 3624 GTDEPRDITVLRNRQVTLECKSDAVPPP------VITWLRNGERLQA-------TPRV-- 3668
Query: 80 DYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ 139
R+ L G LQI + D Y C + + LTVN PP +
Sbjct: 3669 ----RI-LSGGRYLQINNADLGDTANYTCVASNIAGKTTREFI-------LTVNVPPNIK 3716
Query: 140 ETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVER 198
P +++ + V L C+A G P P +TW+ G L + + +NG L I+
Sbjct: 3717 GGPQSLVILLNKSTV-LECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHV 3775
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLT 258
+G Y C A++ G+ L V PP I P N TV + +LAC A P +
Sbjct: 3776 TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIP-KPS 3834
Query: 259 YSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------L 307
+W + N ++ ++ + Q R+L GSL +++ DD Y C +NG +
Sbjct: 3835 INW-RKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTV 3893
Query: 308 LHPPS----ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGS 363
PPS + +L P VI C + P + WTK+G L L + G+ + G+
Sbjct: 3894 QVPPSIADEPTDFLVTKHAPAVITC-TASGVPFPSIHWTKNGIRL-LPRGDGYRILSSGA 3951
Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423
+ I + G Y+C N+ G+A V PP +P E + + +L+P
Sbjct: 3952 IEILATQLNHAGRYTCVARNAAGSAHRHVTLHV--HEPPVIQPQPSELHV-ILNNPILLP 4008
Query: 424 CSAQGDPPPVVSWTKVGRGL----QGQAQVDSNSSLILRPLTKEAHGHWECSASN----A 475
C A G P P ++W K G + + A + S I R + ++A G + C A N A
Sbjct: 4009 CEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDA-GTYMCVAQNPAGTA 4067
Query: 476 VARVATSTNVYVLGTSPHVVTNVSVVALP 504
+ ++ + V + SPH+ V V P
Sbjct: 4068 LGKIKLNVQVPPV-ISPHLKEYVIAVDKP 4095
Score = 127 bits (319), Expect = 6e-29
Identities = 107/378 (28%), Positives = 168/378 (44%), Gaps = 30/378 (7%)
Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQV 186
V L V+ PP Q P + L V P+ L C A G+P P +TW+ G ++ G+ +
Sbjct: 3980 VTLHVHEPPVIQPQP-SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVL 4038
Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
+G L+I R R +G Y C A + G+A +L V PPVI K + + ++L
Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITL 4098
Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
+C A+ P +W +D + R R+L GSL++ QP DAG YTC+ +N
Sbjct: 4099 SCEADGLPPP-DITWHKDGRAIVE----SIRQRVLSSGSLQIAFVQPGDAGHYTCMAAN- 4152
Query: 307 LLHPPSASAYLTVLCMP----------------GVIRCPVRANPPLLFVSWTKDGKALQL 350
+ S S LTV P ++ C V P ++W KD L
Sbjct: 4153 VAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAINWKKD-NVLLA 4210
Query: 351 DKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE 410
+ ++ G LI+ + G Y+C N+ G + + + P F E P +
Sbjct: 4211 NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGE--DTHTVSLTVHVLPTFTELPGD 4268
Query: 411 EYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ-AQVDSNSSLILRPLTKEAHGHWE 469
+ G +L + C A G P P ++WT + V+ +S L++ ++KE G +
Sbjct: 4269 VSLNK-GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYV 4327
Query: 470 CSASNAVARVATSTNVYV 487
C+A N+V V VYV
Sbjct: 4328 CTAENSVGFVKAIGFVYV 4345
Score = 124 bits (311), Expect = 5e-28
Identities = 100/363 (27%), Positives = 168/363 (46%), Gaps = 31/363 (8%)
Query: 152 EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASST 211
+P+TL C A G P P +TW G+ + + Q + +G+L+I V+ G +G YTC A++
Sbjct: 4094 KPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANV 4153
Query: 212 EGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHI 271
GS++ +T+L V PP I + TVN + L C A+ P +W +DN+ +
Sbjct: 4154 AGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTP-AINWKKDNV---LL 4209
Query: 272 SRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL---LHPPSASAYL--TVLCMPG-- 324
+ L + G L L +D+G YTCV +N H S + ++ T +PG
Sbjct: 4210 ANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDV 4269
Query: 325 ------VIRCPVRANP-PLLFVSWTKDGKAL--QLDKFPGWSQGTEGSLIIALGNEDALG 375
+R +A PL ++WT + + D G S+ L+I +++ G
Sbjct: 4270 SLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSE-----LVIERVSKEDSG 4324
Query: 376 EYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVS 435
Y CT NS+G + V +K PP F + + +G ++ C +GDP P +
Sbjct: 4325 TYVCTAENSVGFV--KAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQ 4382
Query: 436 WTKVGRGLQGQAQVD--SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPH 493
W + G ++ ++ N SL + E G + C A+N V S ++ + SP
Sbjct: 4383 WNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTL--QSPP 4440
Query: 494 VVT 496
++T
Sbjct: 4441 IIT 4443
Score = 123 bits (308), Expect = 1e-27
Identities = 110/424 (25%), Positives = 173/424 (40%), Gaps = 41/424 (9%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R R+ SLQI ++ D G Y C + ++ + LTV+ PP+ + T
Sbjct: 4124 RQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG-------SSSTSTKLTVHVPPRIRSTE- 4175
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN-GTLRIRRVERGSSG 202
V E L CVA G P P + WK L G+ + G L + V SG
Sbjct: 4176 GHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSG 4235
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262
YTC A++ G TH L V P P + ++N + + L+C A P F
Sbjct: 4236 FYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTF 4295
Query: 263 QDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL-----------LHPP 311
+NI H + ++++ +D+G Y C N + PP
Sbjct: 4296 NNNIIPAHFDSVNGHSELVIE------RVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP 4349
Query: 312 S-----ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366
S ++ L ++ C V+ +P + W + G +++ Q GSL I
Sbjct: 4350 VFKGDYPSNWIEPLGGNAILNCEVKGDPTPT-IQWNRKGVDIEISH--RIRQLGNGSLAI 4406
Query: 367 -ALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 425
NEDA G+Y+C N G S + L++PP P E G ++++ C
Sbjct: 4407 YGTVNEDA-GDYTCVATNEAGVVERS--MSLTLQSPPIITLEPVETVIN-AGGKIILNCQ 4462
Query: 426 AQGDPPPVVSWTKVGRGLQGQAQVD--SNSSLILRPLTKEAHGHWECSASNAVARVATST 483
A G+P P ++W++ G + +V+ SN+SL + KE +EC A N + V
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522
Query: 484 NVYV 487
V V
Sbjct: 4523 PVIV 4526
Score = 110 bits (274), Expect = 1e-23
Identities = 113/446 (25%), Positives = 180/446 (40%), Gaps = 47/446 (10%)
Query: 92 SLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANG-SWVHLTVNSPPQFQETPPAVLEVQE 150
+L I + + D+G+YEC I G + V+ PP + P V V
Sbjct: 483 NLDIAKVTLSDEGFYEC--------IAVSSAGTGRAQTFFDVSEPPPVIQVPNNVT-VTP 533
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKD--LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208
E L C+ + ++TW+ +D L + + N +L ++ V+ +G Y C
Sbjct: 534 GERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMV 593
Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV 268
SS GS+ + L V PP + V PKN + +VS+ C A YP +W +++ +
Sbjct: 594 SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYP-KPKIAWTVNDMFI 652
Query: 269 FHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------LLHPPS----A 313
R R+ DG+L + P DAG Y C+ SN + P
Sbjct: 653 VG----SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQ 708
Query: 314 SAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDA 373
S L L V+ C PP V W K L+ F G L I +
Sbjct: 709 SELLVALGDITVMECKTSGIPPPQ-VKWFKGDLELRPSTFL-IIDPLLGLLKIQETQDLD 766
Query: 374 LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPV 433
G+Y+C N G A V +PP FI+ P + E+G + +PC QG P P
Sbjct: 767 AGDYTCVAINEAGRATGKITLDV--GSPPVFIQEP-ADVSMEIGSNVTLPCYVQGYPEPT 823
Query: 434 VSWTKVGR--------GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485
+ W ++ + +Q+ + + IL L G + C A N ++ + T V
Sbjct: 824 IKWRRLDNMPIFSRPFSVSSISQLRTGALFILN-LWASDKGTYICEAENQFGKIQSETTV 882
Query: 486 YVLG-TSPHVVTNVSVVALPKGANVS 510
V G +P + + SV + +G ++
Sbjct: 883 TVTGLVAPLIGISPSVANVIEGQQLT 908
Score = 107 bits (266), Expect = 9e-23
Identities = 110/432 (25%), Positives = 176/432 (40%), Gaps = 55/432 (12%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-----LTVNSPPQFQET 141
L G L I +V + G Y C AN + H +TV+ PP + +
Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMA------------ANTAGDHKKEFEVTVHVPPTIKSS 1831
Query: 142 PPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERG 199
+ V + +PV L+C+A G P P +TW + + QG +++Q+ L+I +
Sbjct: 1832 GLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLE 1891
Query: 200 SSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPK--NSTVNASQDVSLACHAEAYPANL 257
+G YTC A++ G QL V PP + K N TV S V L C A P +
Sbjct: 1892 DAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPV 1951
Query: 258 TYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNGL--------- 307
+W++DN + + L G + + + Q DAG Y CV N
Sbjct: 1952 -ITWYKDN----RLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSL 2006
Query: 308 -LH-PPSASAYLTVLCMPGVIRCPVR-----ANPPLLFVSWTKDGKALQLDKFPGWSQGT 360
+H PS S ++ + V+ PVR P ++W KDG + F Q
Sbjct: 2007 QVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLTWLKDGS--PVSSFSNGLQVL 2062
Query: 361 EGSLIIALGNEDA--LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGR 418
G I+AL + G Y+C N+ G RV + P I ++ + +
Sbjct: 2063 SGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV---PPNIMGEEQNVSVLISQ 2119
Query: 419 ELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWECSASNA 475
+ + C + PPP ++W K G L G + ++ S L + + G + C A+N
Sbjct: 2120 AVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNV 2179
Query: 476 VARVATSTNVYV 487
+ + NV +
Sbjct: 2180 AGKTEKNYNVNI 2191
Score = 106 bits (264), Expect = 1e-22
Identities = 132/499 (26%), Positives = 193/499 (38%), Gaps = 62/499 (12%)
Query: 25 EVVSVVG-RAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
E +SVV R G SV L C+ + P VI W + G ++ +
Sbjct: 3064 ESLSVVNVREGTSVSLECE----SNAVPPPVITWYKNGRMITESTHVEI----------- 3108
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
L G L I+ V D G Y CR ++ D N HL V PP +
Sbjct: 3109 ---LADGQMLHIKKAEVSDTGQYVCRAI----NVAGRDDKN---FHLNVYVPPSIEGPER 3158
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNG--TLRIRRVERGS 200
V+ PVTL C A G P P + W K + +V++ +G L+I R +
Sbjct: 3159 EVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSD 3218
Query: 201 SGVYTCQASSTEGSATHATQLLVLGPPVIVVP--PKNSTVNASQDVSLACHAEAYPANLT 258
SG YTC AS+ EG A L + PP + P + +V ++V L C+A P L
Sbjct: 3219 SGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL- 3277
Query: 259 YSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-----------G 306
W +D + S R+R+ +GS L + D G YTCV +N
Sbjct: 3278 IQWLKDGKPI--ASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335
Query: 307 LLHPPS-------ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG 359
+ P+ A +T++ I C PP ++W K+G L L
Sbjct: 3336 VYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQ-INWLKNGLPLPLSSHIRLLAA 3394
Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF-IERPKEEYFQEVGR 418
+ I+ D + Y+C N G +V APP EE G
Sbjct: 3395 GQVIRIVRAQVSD-VAVYTCVASNRAGVDNKHYNLQVF--APPNMDNSMGTEEITVLKGS 3451
Query: 419 ELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD-SNSSLILRPLTKEAH--GHWECSASNA 475
+ C G P P ++W + G+ L A + S ++L+ L E G + C ASN
Sbjct: 3452 STSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNE 3511
Query: 476 VARVATSTNVYVLGTSPHV 494
V+ + VL PH+
Sbjct: 3512 AGEVSKHFILKVL-EPPHI 3529
Score = 105 bits (261), Expect = 3e-22
Identities = 135/510 (26%), Positives = 206/510 (40%), Gaps = 81/510 (15%)
Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
PE +SVV + SV L C+ A PL I W + G+ P+ + S RI
Sbjct: 2393 PENISVVEK--NSVSLTCE----ASGIPLPSITWFKDGW--PVSLS---NSVRI------ 2435
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ-ETP 142
L G L++ +ED G Y C V E+ G L+V PP E
Sbjct: 2436 ---LSGGRMLRLMQTTMEDAGQYTCVV---RNAAGEERKIFG----LSVLVPPHIVGENT 2485
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSS 201
++V+E + VTL C G+P+P +TW G+ L + + + G L+I V+ +
Sbjct: 2486 LEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHT 2545
Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIV-----VPPKNSTVNASQDVSLACHAEAYPAN 256
G YTC ASS G + + L V P I P++ TV + SL C A +YP
Sbjct: 2546 GRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPP- 2604
Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDG-SLRLLATQPDDAGCYTCVPSN---GLLHPPS 312
T +WF+D + +RIL G +L++L Q D+AG Y+CV +N ++
Sbjct: 2605 ATITWFKDGTPL----ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYE 2660
Query: 313 ASAYLTVLCMPGVIRCP--------VRANP-----------PLLFVSWTKDGKALQLDKF 353
Y+ + G + P ++ N P +SW KDG+ L+ D
Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDH 2720
Query: 354 PGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPPAFIERPKEEY 412
+ +L I G Y+C N AG + V ++ PP+F + +
Sbjct: 2721 VNIAANGH-TLQIKEAQISDTGRYTCVASN---IAGEDELDFDVNIQVPPSFQKLWEIGN 2776
Query: 413 FQEVGRE-----------LLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILR 458
+ GR + + C PPP ++W K G L +V L +
Sbjct: 2777 MLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIP 2836
Query: 459 PLTKEAHGHWECSASNAVARVATSTNVYVL 488
E G + C A N + +V VL
Sbjct: 2837 RAKVEDAGRYTCVAVNEAGEDSLQYDVRVL 2866
Score = 104 bits (260), Expect = 4e-22
Identities = 113/414 (27%), Positives = 164/414 (39%), Gaps = 42/414 (10%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146
L +G + IE ++ D G Y+C A + L V+ P + V
Sbjct: 1970 LNRGQIIDIESAQISDAGIYKCVAI-------NSAGATELFYSLQVHVAPSISGSNNMVA 2022
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSGVY 204
V PV L C ARG P P +TW G + +QV +G L + + +G Y
Sbjct: 2023 VVVN-NPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRY 2081
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
TC A + G L V PP I+ +N +V SQ V L C ++A P T +W +D
Sbjct: 2082 TCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPP-TLTWLKD 2140
Query: 265 NINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312
H +P + I + S L++ Q D G YTC +N + PP+
Sbjct: 2141 G----HPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPN 2196
Query: 313 --ASAYLTVLCMPG----VIRCPVRANPPLLFVSWTKDGKALQLDKFPG---WSQGTEGS 363
S LT L + + C PP + W K G + D S G +
Sbjct: 2197 IGGSDELTQLTVIEGNLISLLCESSGIPPPNLI-WKKKGSPVLTDSMGRVRILSGGRQLQ 2255
Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423
+ IA ++ AL YSC N GTA +V ++ E G+ + +
Sbjct: 2256 ISIAEKSDAAL--YSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLE 2313
Query: 424 CSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWECSASN 474
C QG PPP V+W K G L +G +D L L+ + G + C A N
Sbjct: 2314 CEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVN 2367
Score = 98.2 bits (243), Expect = 4e-20
Identities = 124/497 (24%), Positives = 193/497 (38%), Gaps = 63/497 (12%)
Query: 22 GKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDY 81
G E+ + G + L C+ +G PP ++I W + G SP + D
Sbjct: 2199 GSDELTQLTVIEGNLISLLCE---SSGIPPPNLI-WKKKG------------SPVLT-DS 2241
Query: 82 VGRVR-LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQE 140
+GRVR L G LQI D Y C V + ++ ++ T+ +
Sbjct: 2242 MGRVRILSGGRQLQISIAEKSDAALYSC-VASNVAGTAKKEYNLQVYIRPTITN----SG 2296
Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERG 199
+ P + V + ++L C +G P P VTW G L + +G + G L+++ +
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVS 2356
Query: 200 SSGVYTCQASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPAN 256
+G Y C A + G L V PP I+ P+N +V VSL C A P
Sbjct: 2357 DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLP 2416
Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDG-SLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
+ +WF+D V L VRIL G LRL+ T +DAG YTCV N
Sbjct: 2417 -SITWFKDGWPV----SLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG 2471
Query: 316 YLTVLCMPGVI------------------RCPVRANPPLLFVSWTKDGKALQLDKFPGWS 357
L+VL P ++ C V N P+ ++W KDG+ LQ D+
Sbjct: 2472 -LSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGN-PVPEITWHKDGQPLQEDEA---H 2526
Query: 358 QGTEGSLIIALGNEDA--LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI--ERPKEEYF 413
G + + N G Y+C + G S V + A + + E+
Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586
Query: 414 QEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWEC 470
+ + C A PP ++W K G L+ + +L + ++ G + C
Sbjct: 2587 VILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSC 2646
Query: 471 SASNAVARVATSTNVYV 487
A+N + V V
Sbjct: 2647 VATNEAGEMIKHYEVKV 2663
Score = 97.1 bits (240), Expect = 9e-20
Identities = 105/416 (25%), Positives = 165/416 (39%), Gaps = 55/416 (13%)
Query: 128 VHLTVNSPPQ-------FQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQ- 179
V LTV P+ + P + V E VTL C + P P +TW + +
Sbjct: 1064 VQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPF 1123
Query: 180 GQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN 239
+ +G+++I SG+Y C A++ G+ T A +L V PP I PK+ V
Sbjct: 1124 SPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQ 1183
Query: 240 ASQDVSLACHAEAYPANLTYSWFQDNINVF-----HISRLQPRVRILVDGSLRLLATQPD 294
Q V + C+A+ P + +W + + H+S DG+L + P
Sbjct: 1184 VGQRVDIPCNAQGTPLPV-ITWSKGGSTMLVDGEHHVSN--------PDGTLSIDQATPS 1234
Query: 295 DAGCYTCVPSNGL-------------------LHPPSASAYLTVLCMPGV-IRCPVRANP 334
DAG YTCV +N L PP + + + + CP + P
Sbjct: 1235 DAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP 1294
Query: 335 PLLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPV 393
+ W +G+ L + PG S +G+ L+IA GEY C N GT
Sbjct: 1295 KPT-IKWLHNGREL-TGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYN 1352
Query: 394 TRVLLKAPPAFIERPKEEYFQEVGRELL-IPCSAQGDPPPVVSWTKVGRGLQGQAQVDS- 451
+V PP ++ + + +L + C +G P P++ W K + + + +
Sbjct: 1353 LKV--HVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 452 NSSLILR--PLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN----VSVV 501
N+ IL+ T E G + C A N N+ VL + TN VSVV
Sbjct: 1411 NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVV 1466
Score = 96.7 bits (239), Expect = 1e-19
Identities = 100/375 (26%), Positives = 155/375 (41%), Gaps = 35/375 (9%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP---AVL 146
G +LQI +V D G Y C + + F+ LTV PP ++ +V+
Sbjct: 3017 GRTLQIIRAKVSDGGEYTC-IAINQAGESKKKFS------LTVYVPPSIKDHDSESLSVV 3069
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG-QGQVQVQNGTLRIRRVERGSSGVYT 205
V+E V+L C + P P +TW G+ + + ++ L I++ E +G Y
Sbjct: 3070 NVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYV 3129
Query: 206 CQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA-SQDVSLACHAEAYPANLTYSWFQD 264
C+A + G L V PP I P + V S V+L C A P T +W ++
Sbjct: 3130 CRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPP-TIAWLKN 3188
Query: 265 NINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312
+ + + L+ VRIL GS L++ +Q D+G YTC+ SN + PPS
Sbjct: 3189 HKRIENSDSLE--VRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPS 3246
Query: 313 AS-----AYLTVLCMPGV-IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366
+ + ++VL V + C P L + W KDGK + + GS +
Sbjct: 3247 VAGAEIPSDVSVLLGENVELVCNANGIPTPL-IQWLKDGKPIASGETERIRVSANGSTLN 3305
Query: 367 ALGN-EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 425
G G+Y+C N G V + + E+ V + I C
Sbjct: 3306 IYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECR 3365
Query: 426 AQGDPPPVVSWTKVG 440
A G PPP ++W K G
Sbjct: 3366 ATGTPPPQINWLKNG 3380
Score = 94.4 bits (233), Expect = 6e-19
Identities = 116/415 (27%), Positives = 167/415 (40%), Gaps = 52/415 (12%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGS-WVHLTVNSPPQFQETPP-AVLE 147
G LQ+ ED G Y C I ++ S L V PP + +
Sbjct: 3488 GMVLQLLKAETEDSGKYTC--------IASNEAGEVSKHFILKVLEPPHINGSEEHEEIS 3539
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSGVYT 205
V P+ L C+A G P P +TW G+ L Q QVQ G LRI + +G YT
Sbjct: 3540 VIVNNPLELTCIASGIPAPKMTWMKDGRPLPQ-TDQVQTLGGGEVLRISTAQVEDTGRYT 3598
Query: 206 CQASSTEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
C ASS G + V PP I P++ TV ++ V+L C ++A P + +W +
Sbjct: 3599 CLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV-ITWLR 3657
Query: 264 DNINVFHISRLQ--PRVRILVDGS-LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVL 320
+ RLQ PRVRIL G L++ D YTCV SN + + LTV
Sbjct: 3658 NG------ERLQATPRVRILSGGRYLQINNADLGDTANYTCVASN-IAGKTTREFILTVN 3710
Query: 321 CMPG----------------VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364
P V+ C + P ++W KDG A+ +S G L
Sbjct: 3711 VPPNIKGGPQSLVILLNKSTVLEC-IAEGVPTPRITWRKDG-AVLAGNHARYSILENGFL 3768
Query: 365 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424
I + G Y C N+ GT +V PP+ P V + + C
Sbjct: 3769 HIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV--HVPPSIAPGP-TNMTVIVNVQTTLAC 3825
Query: 425 SAQGDPPPVVSWTKVGRGL-----QGQAQVDSNSSLILRPLTKEAHGHWECSASN 474
A G P P ++W K G L Q ++ S+ SL++ + + +EC+ +N
Sbjct: 3826 EATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTN 3880
Score = 89.7 bits (221), Expect = 1e-17
Identities = 121/503 (24%), Positives = 192/503 (38%), Gaps = 61/503 (12%)
Query: 27 VSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID-------- 78
++ GRA + L P + P V + LP ++Q G P I
Sbjct: 775 INEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQ-GYPEPTIKWRRLDNMP 833
Query: 79 ----PDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFAN-GSWVHLTVN 133
P V + + +L I L D+G Y C E+ F S +TV
Sbjct: 834 IFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA--------ENQFGKIQSETTVTVT 885
Query: 134 S-PPQFQETPPAVLEVQELEPVTLRC-VARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTL 191
P+V V E + +TL C + G+P+P W L Q +G+L
Sbjct: 886 GLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSL 945
Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAE 251
I RV+ G YTC AS+ G+ T ++V P I + + V+L C A
Sbjct: 946 HIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKAS 1005
Query: 252 AYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPP 311
P + W + IS + DGSL +++ +++G Y C +N +
Sbjct: 1006 GNP-KPSVIWSKKG---ELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGY-A 1060
Query: 312 SASAYLTVLCMPGV------------------------IRCPVRANPPLLFVSWTKDGKA 347
LTV P V + C V++ PP + ++W K+ +
Sbjct: 1061 KRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI-ITWAKETQL 1119
Query: 348 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 407
+ P + GS+ I G Y C N G + ++ + PP
Sbjct: 1120 IS-PFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNV--TQAVKLNVHVPPKIQRG 1176
Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDS-NSSLILRPLTKEA 464
PK Q VG+ + IPC+AQG P PV++W+K G + G+ V + + +L + T
Sbjct: 1177 PKHLKVQ-VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 465 HGHWECSASNAVARVATSTNVYV 487
G + C A+N T ++V
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHV 1258
Score = 87.8 bits (216), Expect = 5e-17
Identities = 109/439 (24%), Positives = 170/439 (38%), Gaps = 49/439 (11%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R+R SL+++ ++ D G Y C V + ++ + V LTV PP+ P
Sbjct: 567 RIRTLANLSLELKSVKFNDAGEYHCMV-------SSEGGSSAASVFLTVQEPPKVTVMPK 619
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGV 203
E V++ C A G P P + W + + +GTL I+ +G+
Sbjct: 620 NQSFTGGSE-VSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGI 678
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
Y C AS++ G+ + L + P ++V V + C P WF+
Sbjct: 679 YGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPP-QVKWFK 737
Query: 264 DNINVFHISRLQPRVRILVD---GSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV- 319
++ L+P +++D G L++ TQ DAG YTCV N A+ +T+
Sbjct: 738 GDL------ELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAIN---EAGRATGKITLD 788
Query: 320 -------LCMPGVIRCPVRANPPL-LFVSWTKDG--KALQLDKFP---------GWSQGT 360
+ P + + +N L +V + K +LD P SQ
Sbjct: 789 VGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLR 848
Query: 361 EGSLIIALGNEDALGEYSCTPYNSLG-TAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
G+L I G Y C N G + VT L AP I + G++
Sbjct: 849 TGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIE--GQQ 906
Query: 420 LLIPCS-AQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 476
L +PC+ G+P P W K L V S+ SL + + + G + C ASN
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVA 966
Query: 477 A--RVATSTNVYVLGTSPH 493
TS V+VL T H
Sbjct: 967 GTNNKTTSVVVHVLPTIQH 985
Score = 84.7 bits (208), Expect = 5e-16
Identities = 85/322 (26%), Positives = 133/322 (41%), Gaps = 33/322 (10%)
Query: 82 VGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQET 141
+G+ + L +E + +ED G+Y C + ED V LTV+ P F E
Sbjct: 4213 LGKYTAEPYGELILENVVLEDSGFYTC---VANNAAGEDTHT----VSLTVHVLPTFTEL 4265
Query: 142 PPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSS 201
P V + + E + L C A G PLP +TW + V + L I RV + S
Sbjct: 4266 PGDV-SLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVN-GHSELVIERVSKEDS 4323
Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVP-PKNSTVNASQDVSLACHAEAYPANLTYS 260
G Y C A ++ G + V PPV P N + L C + P T
Sbjct: 4324 GTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTP-TIQ 4382
Query: 261 WFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLH 309
W + +++ + R+R L +GSL + T +DAG YTCV +N L
Sbjct: 4383 WNRKGVDI----EISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQS 4438
Query: 310 PP--SASAYLTVLCMPG--VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
PP + TV+ G ++ C P ++W++ G ++ D + + SL
Sbjct: 4439 PPIITLEPVETVINAGGKIILNCQATGEPQPT-ITWSRQGHSISWD--DRVNVLSNNSLY 4495
Query: 366 IALGNEDALGEYSCTPYNSLGT 387
IA ++ E+ C N +G+
Sbjct: 4496 IADAQKEDTSEFECVARNLMGS 4517
Score = 79.3 bits (194), Expect = 2e-14
Identities = 107/467 (22%), Positives = 166/467 (35%), Gaps = 70/467 (14%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETP-PAV 145
+ G L++ ED G Y C+ + + + ++ V PP T P
Sbjct: 1410 VNNGKILKLFRATPEDAGRYSCKAINIAG-------TSQKYFNIDVLVPPTIIGTNFPNE 1462
Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV--QNGTLRIRRVERGSSGV 203
+ V V L C +G+P P + W GK L G V++ + L ++ R G
Sbjct: 1463 VSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGR 1522
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVS--------LACHAEAYPA 255
Y C S+ G +L I +PP N + D+S L C P
Sbjct: 1523 YQCTVSNAAGKQAKDIKL------TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPM 1576
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGS--LRLLATQPDDAGCYTCVPSN-------- 305
+W++D + S+ + +D L + Q D+ YTC +N
Sbjct: 1577 P-AITWYKDGQPIMSSSQ-----ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKS 1630
Query: 306 ---GLLHPPSASAYL-------TVLCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFP 354
+ PP L V+ + C NP P+L +W KDG ++ +
Sbjct: 1631 FHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPIL--TWLKDGVPVKANDNI 1688
Query: 355 GWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPPAFIERPKEEYF 413
G + L I E G+Y C + AG + V + PPA + YF
Sbjct: 1689 RIEAGGK-KLEIMSAQEIDRGQYICV---ATSVAGEKEIKYEVDVLVPPAIEGGDETSYF 1744
Query: 414 QEVGRELL-IPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEAHGHWE 469
+ LL + C G PPP + W K G+ + G + + L++ G +
Sbjct: 1745 IVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYR 1804
Query: 470 CSASNAV--------ARVATSTNVYVLGTSPHVVTNVSVVALPKGAN 508
C A+N V + G S VV VAL AN
Sbjct: 1805 CMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIAN 1851
Score = 79.0 bits (193), Expect = 3e-14
Identities = 108/415 (26%), Positives = 166/415 (40%), Gaps = 51/415 (12%)
Query: 151 LEPVTLRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQAS 209
L+P + C S LP +R G LG Q + + L I +V G Y C A
Sbjct: 444 LQPGQIPCSV-DSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAV 502
Query: 210 STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC-HAEAYPANLTYSWFQDNINV 268
S+ G+ T V PP ++ P N TV + L C A NLT+ ++ +
Sbjct: 503 SSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRL 562
Query: 269 FHISRLQPRVRILVDGSLRLLATQPDDAGCYTC-VPSNGLLHPPSASAYLTVLCMPGVIR 327
R+R L + SL L + + +DAG Y C V S G +AS +LTV P V
Sbjct: 563 AE----PARIRTLANLSLELKSVKFNDAGEYHCMVSSEG--GSSAASVFLTVQEPPKVTV 616
Query: 328 CPVR---------------ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNED 372
P P ++WT + + + + ++G+L I
Sbjct: 617 MPKNQSFTGGSEVSIMCSATGYPKPKIAWTVND--MFIVGSHRYRMTSDGTLFIKNAAPK 674
Query: 373 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPP 432
G Y C NS GT + R ++AP + + E +G ++ C G PPP
Sbjct: 675 DAGIYGCLASNSAGTDKQNSTLR-YIEAPKLMV--VQSELLVALGDITVMECKTSGIPPP 731
Query: 433 VVSWTKVGRGLQGQAQVDSNSSLILRPL--------TKEAH-GHWECSASNAVARVATST 483
V W K G ++ ++ LI+ PL T++ G + C A N R AT
Sbjct: 732 QVKWFK------GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGR-ATGK 784
Query: 484 NVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVW----YTPLAKRP 534
+G+ P + + V++ G+NV+ P + GY + W P+ RP
Sbjct: 785 ITLDVGSPPVFIQEPADVSMEIGSNVTL-PCYVQGYPEPTIKWRRLDNMPIFSRP 838
Score = 77.4 bits (189), Expect = 7e-14
Identities = 128/550 (23%), Positives = 204/550 (37%), Gaps = 98/550 (17%)
Query: 17 GADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPR 76
G G PE V+V+ + S+V PPA I W + G L +
Sbjct: 2575 GVGSDGNPEDVTVILNSPTSLVCEAYSYPPA------TITWFKDGTPLESNRNIRI---- 2624
Query: 77 IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS-- 134
L G +LQI + ++ G Y C + A H V
Sbjct: 2625 ----------LPGGRTLQILNAQEDNAGRYSCVA---------TNEAGEMIKHYEVKVYI 2665
Query: 135 PPQFQE-------TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
PP + P ++++ +TL C A P ++W G+ L
Sbjct: 2666 PPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA 2725
Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPV---------IVVPPKNST 237
NG TL+I+ + +G YTC AS+ G + + PP ++ +N
Sbjct: 2726 NGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGE 2785
Query: 238 ---VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQP 293
V + +SL C A P T +W++D H +V IL G L++ +
Sbjct: 2786 AKDVIINNPISLYCETNAAPPP-TLTWYKDG----HPLTSSDKVLILPGGRVLQIPRAKV 2840
Query: 294 DDAGCYTCVPSNG-----------LLHPPSASAY-------LTVLCMPGVIRCPVRANPP 335
+DAG YTCV N +L PP +TVL + + + P
Sbjct: 2841 EDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSP 2900
Query: 336 LLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDA-LGEYSCTPYNSLGTAGPSPVT 394
SW KDG+ L D + + G ++ L + +G Y C N+ G+A
Sbjct: 2901 APRNSWQKDGQPLLEDDHHKFL--SNGRILQILNTQITDIGRYVCVAENTAGSA--KKYF 2956
Query: 395 RVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSS 454
+ + PP+ I E V + + C G PPP +SW L+ + + N++
Sbjct: 2957 NLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSW------LKNEQPIKLNTN 3010
Query: 455 LILRPLTKEAH---------GHWECSASNAV--ARVATSTNVYV-LGTSPHVVTNVSVVA 502
++ P + G + C A N ++ S VYV H ++SVV
Sbjct: 3011 TLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVN 3070
Query: 503 LPKGANVSWE 512
+ +G +VS E
Sbjct: 3071 VREGTSVSLE 3080
Score = 47.4 bits (111), Expect = 8e-05
Identities = 52/215 (24%), Positives = 83/215 (38%), Gaps = 33/215 (15%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G + +L C++ P I+W R G +D + R+R SL
Sbjct: 4364 GGNAILNCEVKGD----PTPTIQWNRKG---------------VDIEISHRIRQLGNGSL 4404
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I G ED G Y C V + + E + LT+ SPP P + +
Sbjct: 4405 AIYGTVNEDAGDYTC-VATNEAGVVERSMS------LTLQSPPIITLEPVETV-INAGGK 4456
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEG 213
+ L C A G P P +TW +G + + N +L I ++ + + C A + G
Sbjct: 4457 IILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516
Query: 214 SATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248
S +LV P ++ V S +A + S+ C
Sbjct: 4517 S------VLVRVPVIVQVHGGFSQWSAWRACSVTC 4545
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 134 bits (337), Expect = 5e-31
Identities = 169/660 (25%), Positives = 252/660 (38%), Gaps = 99/660 (15%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP L C RG P P + WK + + ++ ++ G L I
Sbjct: 151 FRQNPTDVV-VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNT 209
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G+YTC ++ G + +L V P + P N V + V C + P
Sbjct: 210 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 269
Query: 256 NLTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSA 313
T W +D+ ++ PR R I D +LR+ T D G Y C+ N + A
Sbjct: 270 P-TVRWKKDDADL-------PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRV-GKMEA 320
Query: 314 SAYLTVLCMPG-VIR---------------CPVRANP-PLLFVSWTKDGKALQLDKFPGW 356
SA LTV P V+R C + NP P +F W K+G L FP
Sbjct: 321 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF--WQKEGSQNLL--FPNQ 376
Query: 357 SQ--------GTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFI 405
Q G L I G Y C T S+ VT VL PP I
Sbjct: 377 PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII 436
Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG---RGLQGQAQVDSNSSLILRPLTK 462
+ V L+ C A GDP PV+SW K G G +A + +L ++ L
Sbjct: 437 LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 496
Query: 463 EAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-------------KGANV 509
G + C A+++ + S + V + + N + LP +
Sbjct: 497 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 556
Query: 510 SWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVL 569
SW+PG G + + + + W ++A V V GL+P+T Y F V
Sbjct: 557 SWQPGTPGTLPASAYI----IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVR 612
Query: 570 AQNKLG---SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVR-------T 619
A N G P S+ V + +P A G+ ++ L G V VR T
Sbjct: 613 AINPQGLSDPSPMSDPVRTQ----DISPPAQGVDHRQVQKEL----GDVLVRLHNPVVLT 664
Query: 620 PRGVLLHWDPPELVPKRLDGYVL-----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDV 674
P V + W + P+ + GY + G Q + W+ LD V TE ++ L K V
Sbjct: 665 PTTVQVTW-TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP-TERSAVLVNLKKGV 722
Query: 675 LYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAV 734
YE ++ + F S + V T+ + P PQ V VG ++V
Sbjct: 723 TYEIKVRPYFNEFQGMDSESKTVRTT--------EEAPSAPPQSVTVLTVGSYNSTSISV 774
Score = 97.8 bits (242), Expect = 5e-20
Identities = 139/607 (22%), Positives = 219/607 (36%), Gaps = 78/607 (12%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P V+ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 46 PPRIVEHPSDVI-VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G G Y C A + G A +A+ + L P + V A +
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 164
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
L C T W +D + I + R+ I G L + T+ DAG YTCV
Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKV---RIDDKEERISIR-GGKLMISNTRKSDAGMYTCV 220
Query: 303 PSNGLLHPPSASAYLTVLCMPGVIRCPVR---------------ANPPLLFVSWTKDGKA 347
+N + S A LTV P +R P+ P V W KD
Sbjct: 221 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 280
Query: 348 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 407
L ++ + +L I G Y C N +G S V +APP F+ R
Sbjct: 281 LPRGRY---DIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVR 335
Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG----------RGLQGQAQVDSNSSLIL 457
P+++ + GR + PC +G+P P V W K G + + V L +
Sbjct: 336 PRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 394
Query: 458 RPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDG 517
+ + G++ C A + + V + + L AN + DG
Sbjct: 395 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDV---LTDRPPPIILQGPANQTL--AVDG 449
Query: 518 GYLQRFSVWYTPLAKRPDRMHHDWVS----------LAVPVGAAHLLVPGLQPHTQYQFS 567
L + PL W+ A L + L+ ++
Sbjct: 450 TALLKCKATGDPLPV------ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 503
Query: 568 VLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHW 627
+A + G +S ++ G + +++P P S P+ V T V L W
Sbjct: 504 CVATSSSGETSWSAVLDVTESG---ATISKNYDLSDLPGPPSKPQ--VTDVTKNSVTLSW 558
Query: 628 DPPELVPKRLDGYVLE--GRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAG 685
P Y++E + S W+ + V T V GL + +Y F + A
Sbjct: 559 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV--KTTLYTVRGLRPNTIYLFMVRAINP 616
Query: 686 SFVSDPS 692
+SDPS
Sbjct: 617 QGLSDPS 623
Score = 85.5 bits (210), Expect = 3e-16
Identities = 104/391 (26%), Positives = 147/391 (37%), Gaps = 50/391 (12%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
VV AGE +L C PP G P I W + RID D R+ +
Sbjct: 158 VVVAAGEPAILECQ--PPRGHPE-PTIYWKKD-------------KVRID-DKEERISI- 199
Query: 89 KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEV 148
+G L I R D G Y C + D LTV P F P + +
Sbjct: 200 RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP------AELTVFERPTFLRRPINQVVL 253
Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208
+E E V RC +G P P V WK DL +G+ ++ + TLRI++ G Y C A
Sbjct: 254 EE-EAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK-DDYTLRIKKTMSTDEGTYMCIA 311
Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN- 267
+ G + L V PP VV P++ V + V+ C + P + + + N
Sbjct: 312 ENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNL 371
Query: 268 VFHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC---VPSNGLLHPP--SASAYLTVL 320
+F QP R V G L + Q DAG Y C + +L + LT
Sbjct: 372 LFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 431
Query: 321 CMPGVIRCPVR---------------ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
P +++ P PL +SW K+G + P + +G+L
Sbjct: 432 PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP-GRDPRATIQEQGTLQ 490
Query: 366 IALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396
I G Y+C +S G S V V
Sbjct: 491 IKNLRISDTGTYTCVATSSSGETSWSAVLDV 521
Score = 37.4 bits (85), Expect = 0.084
Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 16/88 (18%)
Query: 23 KPEVVSVVGRAGESVVL-GCDLLP-PAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPD 80
+P + + G A +++ + G LL A PL VI WL+ GF P DP
Sbjct: 431 RPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP----------GRDP- 479
Query: 81 YVGRVRLQKGASLQIEGLRVEDQGWYEC 108
R +Q+ +LQI+ LR+ D G Y C
Sbjct: 480 ---RATIQEQGTLQIKNLRISDTGTYTC 504
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 134 bits (337), Expect = 5e-31
Identities = 169/660 (25%), Positives = 252/660 (38%), Gaps = 99/660 (15%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP L C RG P P + WK + + ++ ++ G L I
Sbjct: 135 FRQNPTDVV-VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNT 193
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G+YTC ++ G + +L V P + P N V + V C + P
Sbjct: 194 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 253
Query: 256 NLTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSA 313
T W +D+ ++ PR R I D +LR+ T D G Y C+ N + A
Sbjct: 254 P-TVRWKKDDADL-------PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRV-GKMEA 304
Query: 314 SAYLTVLCMPG-VIR---------------CPVRANP-PLLFVSWTKDGKALQLDKFPGW 356
SA LTV P V+R C + NP P +F W K+G L FP
Sbjct: 305 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF--WQKEGSQNLL--FPNQ 360
Query: 357 SQ--------GTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFI 405
Q G L I G Y C T S+ VT VL PP I
Sbjct: 361 PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII 420
Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG---RGLQGQAQVDSNSSLILRPLTK 462
+ V L+ C A GDP PV+SW K G G +A + +L ++ L
Sbjct: 421 LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 480
Query: 463 EAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-------------KGANV 509
G + C A+++ + S + V + + N + LP +
Sbjct: 481 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 540
Query: 510 SWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVL 569
SW+PG G + + + + W ++A V V GL+P+T Y F V
Sbjct: 541 SWQPGTPGTLPASAYI----IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVR 596
Query: 570 AQNKLG---SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVR-------T 619
A N G P S+ V + +P A G+ ++ L G V VR T
Sbjct: 597 AINPQGLSDPSPMSDPVRTQ----DISPPAQGVDHRQVQKEL----GDVLVRLHNPVVLT 648
Query: 620 PRGVLLHWDPPELVPKRLDGYVL-----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDV 674
P V + W + P+ + GY + G Q + W+ LD V TE ++ L K V
Sbjct: 649 PTTVQVTW-TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP-TERSAVLVNLKKGV 706
Query: 675 LYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAV 734
YE ++ + F S + V T+ + P PQ V VG ++V
Sbjct: 707 TYEIKVRPYFNEFQGMDSESKTVRTT--------EEAPSAPPQSVTVLTVGSYNSTSISV 758
Score = 97.8 bits (242), Expect = 5e-20
Identities = 139/607 (22%), Positives = 219/607 (36%), Gaps = 78/607 (12%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P V+ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 30 PPRIVEHPSDVI-VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G G Y C A + G A +A+ + L P + V A +
Sbjct: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 148
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
L C T W +D + I + R+ I G L + T+ DAG YTCV
Sbjct: 149 PAILECQPPRGHPEPTIYWKKDKV---RIDDKEERISIR-GGKLMISNTRKSDAGMYTCV 204
Query: 303 PSNGLLHPPSASAYLTVLCMPGVIRCPVR---------------ANPPLLFVSWTKDGKA 347
+N + S A LTV P +R P+ P V W KD
Sbjct: 205 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 264
Query: 348 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 407
L ++ + +L I G Y C N +G S V +APP F+ R
Sbjct: 265 LPRGRY---DIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVR 319
Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG----------RGLQGQAQVDSNSSLIL 457
P+++ + GR + PC +G+P P V W K G + + V L +
Sbjct: 320 PRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378
Query: 458 RPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDG 517
+ + G++ C A + + V + + L AN + DG
Sbjct: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDV---LTDRPPPIILQGPANQTL--AVDG 433
Query: 518 GYLQRFSVWYTPLAKRPDRMHHDWVS----------LAVPVGAAHLLVPGLQPHTQYQFS 567
L + PL W+ A L + L+ ++
Sbjct: 434 TALLKCKATGDPLPV------ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487
Query: 568 VLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHW 627
+A + G +S ++ G + +++P P S P+ V T V L W
Sbjct: 488 CVATSSSGETSWSAVLDVTESG---ATISKNYDLSDLPGPPSKPQ--VTDVTKNSVTLSW 542
Query: 628 DPPELVPKRLDGYVLE--GRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAG 685
P Y++E + S W+ + V T V GL + +Y F + A
Sbjct: 543 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV--KTTLYTVRGLRPNTIYLFMVRAINP 600
Query: 686 SFVSDPS 692
+SDPS
Sbjct: 601 QGLSDPS 607
Score = 85.5 bits (210), Expect = 3e-16
Identities = 104/391 (26%), Positives = 147/391 (37%), Gaps = 50/391 (12%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
VV AGE +L C PP G P I W + RID D R+ +
Sbjct: 142 VVVAAGEPAILECQ--PPRGHPE-PTIYWKKD-------------KVRID-DKEERISI- 183
Query: 89 KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEV 148
+G L I R D G Y C + D LTV P F P + +
Sbjct: 184 RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP------AELTVFERPTFLRRPINQVVL 237
Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA 208
+E E V RC +G P P V WK DL +G+ ++ + TLRI++ G Y C A
Sbjct: 238 EE-EAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK-DDYTLRIKKTMSTDEGTYMCIA 295
Query: 209 SSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN- 267
+ G + L V PP VV P++ V + V+ C + P + + + N
Sbjct: 296 ENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNL 355
Query: 268 VFHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC---VPSNGLLHPP--SASAYLTVL 320
+F QP R V G L + Q DAG Y C + +L + LT
Sbjct: 356 LFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 415
Query: 321 CMPGVIRCPVR---------------ANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
P +++ P PL +SW K+G + P + +G+L
Sbjct: 416 PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP-GRDPRATIQEQGTLQ 474
Query: 366 IALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396
I G Y+C +S G S V V
Sbjct: 475 IKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
Score = 37.4 bits (85), Expect = 0.084
Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 16/88 (18%)
Query: 23 KPEVVSVVGRAGESVVL-GCDLLP-PAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPD 80
+P + + G A +++ + G LL A PL VI WL+ GF P DP
Sbjct: 415 RPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFP----------GRDP- 463
Query: 81 YVGRVRLQKGASLQIEGLRVEDQGWYEC 108
R +Q+ +LQI+ LR+ D G Y C
Sbjct: 464 ---RATIQEQGTLQIKNLRISDTGTYTC 488
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 130 bits (326), Expect = 9e-30
Identities = 178/725 (24%), Positives = 282/725 (38%), Gaps = 108/725 (14%)
Query: 154 VTLRCVARGSP-LPHVTWKLRGKDL--GQGQGQVQVQNGTLRIRRV-----ERGSSGVYT 205
V L C A +P + WK G L G + + Q+ NG+L I+ + + G+Y
Sbjct: 57 VLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQ 116
Query: 206 CQASSTEGSA--THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
C+AS + + + ++ V GP + ++ T V L C P T W +
Sbjct: 117 CEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMP-TIHWQK 175
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMP 323
+ ++ I RV +L G+L++ QP D G Y C N A + +L P
Sbjct: 176 NQQDLTPIPG-DSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDP 234
Query: 324 G----------------------VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTE 361
G V+ C V PP F +W + + +QL + +S
Sbjct: 235 GLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSF-TWLRGEEVIQL-RSKKYSLLGG 292
Query: 362 GSLIIALGNEDALGEYSC-TPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420
+L+I+ +D G Y+C Y + + + +T + PP F+ P Y E ++
Sbjct: 293 SNLLISNVTDDDSGMYTCVVTYKNENISASAELT---VLVPPWFLNHPSNLYAYE-SMDI 348
Query: 421 LIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR 478
C+ G P P V+W K G + Q+ S+L + + K G ++C A N
Sbjct: 349 EFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGN 408
Query: 479 VATSTNVY----------VLGTSPHVVTNVSVVALPKGANVSWEPGFDG-GYLQRFSVWY 527
TS + VL ++P V V V+ + +SW P + G +Q F+V++
Sbjct: 409 AQTSAQLIVPKPAIPSSSVLPSAPRDV--VPVLVSSRFVRLSWRPPAEAKGNIQTFTVFF 466
Query: 528 TPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAP 587
+ +R + G+ L V L+P Y F V+A N+ G G S+ + A
Sbjct: 467 SREGDNRERALN-----TTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521
Query: 588 EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRT-PRGVLLHWDPPELVPKRLDGYVLEGRQ 646
+ P ++P P+ L AV T P +L+ W+PP + GY L +
Sbjct: 522 Q-----------PELQVPGPV---ENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTE 567
Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNT---------A 695
S G E + V G +L GL K Y R +A+ G VS T A
Sbjct: 568 VSTGKE-QNIEVDGLSYKL--EGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSA 624
Query: 696 NVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRK 755
LEV SR+ LP P +G G + G + R+ RR
Sbjct: 625 PPQNVSLEVVNSRSIKVSWLPPP--SGTQNG-----------FITGYKIRHRKTTRRGEM 671
Query: 756 RLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHP 815
+ L + TG GS V+ + + G+ PS + + S P
Sbjct: 672 ETLEPNNLWYLFTGLEK-----GSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVP 726
Query: 816 DPPSS 820
D PSS
Sbjct: 727 DQPSS 731
Score = 76.3 bits (186), Expect = 2e-13
Identities = 187/772 (24%), Positives = 286/772 (37%), Gaps = 118/772 (15%)
Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGF-LLPIFIQFGLYSPRIDPDYVGRVR 86
SV G++V+L C+++ P+ I W + L PI P V
Sbjct: 148 SVTAFMGDTVLLKCEVIGE----PMPTIHWQKNQQDLTPI------------PGDSRVVV 191
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP------QFQE 140
L GA LQI L+ D G Y C P G+ + + S P F +
Sbjct: 192 LPSGA-LQISRLQPGDIGIYRCSA-----RNPASS-RTGNEAEVRILSDPGLHRQLYFLQ 244
Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVER 198
P V+ ++ + V L C G P P TW LRG+++ Q + + G L I V
Sbjct: 245 RPSNVVAIEGKDAV-LECCVSGYPPPSFTW-LRGEEVIQLRSKKYSLLGGSNLLISNVTD 302
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLT 258
SG+YTC + + + + +L VL PP + P N S D+ C P T
Sbjct: 303 DDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP-T 361
Query: 259 YSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN---------GLLH 309
+W ++ V Q I+ +LR+L D G Y CV N L+
Sbjct: 362 VNWMKNGDVVIPSDYFQ----IVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV 417
Query: 310 PPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKA---LQL----------DKFPGW 356
P A +VL PV + + +SW +A +Q ++
Sbjct: 418 PKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERAL 477
Query: 357 SQGTEGSLIIALGN--EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQ 414
+ GSL + +GN +A+ + YN G S +V + P + P E Q
Sbjct: 478 NTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQ-PELQVPGPVEN-LQ 535
Query: 415 EVG---RELLI----PCSAQGDPPPVVSW----TKVGRGLQGQAQVDSNSSLILRPLTKE 463
V +LI P A G PV + T+V G + +VD S L L K
Sbjct: 536 AVSTSPTSILITWEPPAYANG---PVQGYRLFCTEVSTGKEQNIEVD-GLSYKLEGLKKF 591
Query: 464 AHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSV-VALPKGANVSWEP---GFD 516
A N ++ ++ V+ S NVS+ V + VSW P G
Sbjct: 592 TEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQ 651
Query: 517 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGS 576
G++ + + + +R + + P +L GL+ +QY F V A G+
Sbjct: 652 NGFITGYKIRHRKTTRRGE------METLEPNNLWYLFT-GLEKGSQYSFQVSAMTVNGT 704
Query: 577 GPFSE-IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635
GP S PE L +++P P L +++ W PP
Sbjct: 705 GPPSNWYTAETPEN--------DLDESQVP---DQPSSLHVRPQTNCIIMSWTPPLNPNI 753
Query: 636 RLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVS--DP 691
+ GY++ GS E + V + + L Y L AF AG V +
Sbjct: 754 VVRGYIIGYGVGSPYAETV--RVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYES 811
Query: 692 SNTANVS--TSGLEVYPSRTQLPGLLPQ---PVLAGV-VGGVCFLGVAVLVS 737
+ T +++ T ++ YP P +P P+L V V V AV VS
Sbjct: 812 ATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVS 863
Score = 41.6 bits (96), Expect = 0.004
Identities = 114/537 (21%), Positives = 175/537 (32%), Gaps = 104/537 (19%)
Query: 557 GLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVA 616
GL+P+T Y+FSV+ S +S + T AAP P ++ +
Sbjct: 909 GLKPNTMYEFSVMVTKNRRSSTWSMTAHAT-----TYEAAPTSAPKDLTV-------ITR 956
Query: 617 VRTPRGVLLHWDPPELVPKRLDGYV----LEGRQGSQGWEVLDPAVAGTETELLVPGLIK 672
PR V++ W PP ++ Y+ L+ W + ++G + L
Sbjct: 957 EGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDW--IMETISGDRLTHQIMDLNL 1014
Query: 673 DVLYEFRL--------------VAFAGSFVSDPSNTAN-----------------VSTSG 701
D +Y FR+ + F V P AN + S
Sbjct: 1015 DTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRST 1074
Query: 702 LEVYPSRTQLP---GLLPQPVLAGVVGGVCFLGV-AVLVSILAGCLLNRRRAARRRRKRL 757
L P P + PQ +V V +GV VLV ++ + RR +A++R+KR
Sbjct: 1075 LNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRA 1134
Query: 758 RQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDP 817
P + ++ P+ R S + TP H
Sbjct: 1135 THSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQS 1194
Query: 818 PSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSP-- 875
+ G G D + R A R P +L D S++P
Sbjct: 1195 ETQLGSKSTSH--SGQDTE-----EAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAV 1247
Query: 876 -SGAPQPLCIEDISPVAPPPAAPPSPLPG-PGPLLQYLSLPFFREMNVD----------- 922
S P P A P PSP G P P +P F ++VD
Sbjct: 1248 VSAIPVPTL-----ESAQYPGILPSPTCGYPHPQFTLRPVP-FPTLSVDRGFGAGRSQSV 1301
Query: 923 GDWPPLEEPS--PAAPPDYMDTRRCPTSSF----------LRS---PETPP----VSPRE 963
+ P ++P P + P++ + P+ + LRS P PP + P+
Sbjct: 1302 SEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKV 1361
Query: 964 SLPGAVVGAGATAEPPYTALADWTL----RERLLPGLLPAAPRGSLTSQSSGRGSAS 1016
+ G T + A L R LLP +P AP S S SA+
Sbjct: 1362 PYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSAN 1418
Score = 36.2 bits (82), Expect = 0.19
Identities = 24/96 (25%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 490 TSPHVVTNVSVVALPKGANVSWEPGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPV 548
++P +T ++ P+ VSW+P + G + + ++YT P DW+ +
Sbjct: 946 SAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPI---DDWIMETISG 1002
Query: 549 GAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVL 584
+ L T Y F + A+N G GP S+ +L
Sbjct: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPIL 1038
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 125 bits (313), Expect = 3e-28
Identities = 133/492 (27%), Positives = 191/492 (38%), Gaps = 63/492 (12%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86
VVG A +VL C + P I W R G +L QF
Sbjct: 2400 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 2440
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144
++G LQ++ L D G Y C + A + V + +++ P + PPA
Sbjct: 2441 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 2490
Query: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203
V V + L C A G P P V+W+ L + ++ G+LRI+ V +G
Sbjct: 2491 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2549
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
Y C AS++ GS L VL PP I P N T+ A L C A P L W
Sbjct: 2550 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 2609
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL----------LHPPSA 313
F + Q R+L +L L A P D+ + CV SN + +H P
Sbjct: 2610 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2667
Query: 314 SA-----YLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368
A + + P V+ C P VSW+K G L + G+ G+L I
Sbjct: 2668 IADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEIGQ 2725
Query: 369 GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPCSAQ 427
G Y+C+ NS G A V L + + +P + V E+L+PC A
Sbjct: 2726 ALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2781
Query: 428 GDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485
G P P ++W K G + QV L + + E G++ C A N+ T +
Sbjct: 2782 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2841
Query: 486 YVLGTSPHVVTN 497
V P V+ N
Sbjct: 2842 VV--QVPPVIEN 2851
Score = 116 bits (290), Expect = 1e-25
Identities = 109/386 (28%), Positives = 161/386 (41%), Gaps = 37/386 (9%)
Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
V LTV + P + P V V E E V L C A G P P +TW+ G ++ G +
Sbjct: 2749 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 2807
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
G LRI +G Y C A ++ GSA T+L+V PPVI + + L
Sbjct: 2808 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 2867
Query: 248 CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
C A P N+T W +D V S + + I G L + + DAG YTC N
Sbjct: 2868 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 2922
Query: 307 LLHPPSASAYLTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQL 350
+ +LT+L +P +RC R +P + WT + + +
Sbjct: 2923 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 2979
Query: 351 DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408
G S+ GS + A+ ED+ G Y C N +G V+ V +K P
Sbjct: 2980 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 3033
Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 466
+ VG + + C +GDP P + W K G L+G N SL + ++ G
Sbjct: 3034 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAG 3093
Query: 467 HWECSASNAVARVATSTNVYVLGTSP 492
++C A N + VA + VL ++P
Sbjct: 3094 RYQCLAENEMG-VAKKVVILVLQSAP 3118
Score = 108 bits (270), Expect = 3e-23
Identities = 121/487 (24%), Positives = 190/487 (39%), Gaps = 64/487 (13%)
Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
P VV V A E V+L C+ A P I W + G + +
Sbjct: 2763 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 2802
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142
++ G L+I ED G Y C I ++ + L V PP +
Sbjct: 2803 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 2853
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201
P L E L C ARGSP P++TW G+ + +G+ +Q +G L ++ +E +
Sbjct: 2854 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 2912
Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261
G YTC A + G A L +L PV P + ++ + L C A P
Sbjct: 2913 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2972
Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSAS------- 314
D +S +L+ A +D+G Y C N + + S
Sbjct: 2973 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 3026
Query: 315 --------AYLTVLCMPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364
+YL V + G I+ C VR +P + + W KDG L+ Q GSL
Sbjct: 3027 PVLQGEAFSYL-VEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSL 3082
Query: 365 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424
I D G Y C N +G A V ++L++ P F P++ + G ++ + C
Sbjct: 3083 TIHRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 3139
Query: 425 SAQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATS 482
A G+P P + W + G+ L+ ++ + + SL L + G ++C A N +
Sbjct: 3140 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 3199
Query: 483 TNVYVLG 489
+ V G
Sbjct: 3200 AFLVVRG 3206
Score = 108 bits (269), Expect = 4e-23
Identities = 119/448 (26%), Positives = 180/448 (40%), Gaps = 63/448 (14%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139
L +G LQI+ +V D G Y C + +D ++ + PP FQ
Sbjct: 1498 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 1550
Query: 140 ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
E V E +E+ P L C P P +TW + L G +Q
Sbjct: 1551 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 1610
Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242
G L+I V ++G Y+C+AS+ G +LLVL PPVI+ + TVNAS
Sbjct: 1611 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 1670
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301
VSL C A P T SW Q+ + PR+++L DG L++ + DA Y C
Sbjct: 1671 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 1725
Query: 302 VPSN-----------GLLHPPSASA----YLTVLCMPGV-IRCPVRANPPLLFVSWTKDG 345
V N + PP + +T + V + C V A+P V+W KD
Sbjct: 1726 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWYKDS 1784
Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
+AL L + GT +L + G Y+C N+ G + ++ + PPAF
Sbjct: 1785 QALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPPAFR 1841
Query: 406 ERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRP 459
+ P+ + VG + ++ C P P V+W K G+ L Q + L ++
Sbjct: 1842 QAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 1901
Query: 460 LTKEAHGHWECSASNAVARVATSTNVYV 487
G + C SN + + V
Sbjct: 1902 AQVSDKGLYSCKVSNVAGEAVRTFTLTV 1929
Score = 106 bits (264), Expect = 1e-22
Identities = 145/506 (28%), Positives = 211/506 (41%), Gaps = 81/506 (16%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92
G+ V L C+ G+PP V WL+ G SP + D +R G S
Sbjct: 2041 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 2083
Query: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150
L ++GLR D G Y C H P + A V++ V PP ++ L +
Sbjct: 2084 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 2136
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209
E VT+ C RGSP HV+W G L Q + +G TLRI +V+ +G++TC A+
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2196
Query: 210 STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
S G A L V PPV+ V + V V L C A P L SW +D
Sbjct: 2197 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 2255
Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPP--SAS 314
+ S Q SL+L A D+G Y+CV + ++ PP S
Sbjct: 2256 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2308
Query: 315 AYLTVLCM----PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGN 370
T L + P + C + P ++W KDG+A L + S+ T L
Sbjct: 2309 GQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLRV 2360
Query: 371 EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSAQ 427
DA G Y+C + G S RV ++APP + P+ F VG +L++ CS +
Sbjct: 2361 RDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSVE 2415
Query: 428 GDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 484
+P P ++W + G LQ A + L L+ L+ G + C+A NA + +
Sbjct: 2416 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475
Query: 485 VYVLGTSPHVVTNVSVVALPKGANVS 510
V + H V + + P NVS
Sbjct: 2476 VEI-----HTVPTIR--SGPPAVNVS 2494
Score = 103 bits (257), Expect = 1e-21
Identities = 137/498 (27%), Positives = 188/498 (37%), Gaps = 76/498 (15%)
Query: 26 VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85
V V A +V L C PA P+ I WL+ G LP SPR+
Sbjct: 1661 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 1703
Query: 86 RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140
L+ G LQ+ V D Y C + E+ + + L V PP+ E
Sbjct: 1704 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 1754
Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198
A+L V+L C P P VTW + L G+ +V + GT L++ R
Sbjct: 1755 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 1809
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254
SG+YTC+A + G QL VL PP P+ V L+C +A P
Sbjct: 1810 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1869
Query: 255 ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-------- 305
T +W++D + L R + L G L + Q D G Y+C SN
Sbjct: 1870 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRT 1924
Query: 306 --------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-W 356
P V P V+ C V + P V+W KD ++ G
Sbjct: 1925 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGVV 1983
Query: 357 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 416
S+G G L ++ G Y+C N+ A V VL+ AP E+
Sbjct: 1984 SRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVLE 2040
Query: 417 GRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWEC 470
G+E+ + C A G PPP V+W K G L GQ SL+L+ L G + C
Sbjct: 2041 GQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2099
Query: 471 SASNAVARVATSTNVYVL 488
A N A V VL
Sbjct: 2100 VAHNPAGEDARLHTVNVL 2117
Score = 102 bits (253), Expect = 3e-21
Identities = 113/430 (26%), Positives = 172/430 (40%), Gaps = 47/430 (10%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147
G L + ++ +G Y C + + +D + L V+ PPQ PP +
Sbjct: 1026 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 1078
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206
V + TL C A G P P VTW+ G+ +G G Q+Q Q +L + R + +G Y+C
Sbjct: 1079 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1138
Query: 207 QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
A + G A +L VL PP ++ P N T ++L C A P WF+
Sbjct: 1139 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 1197
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312
V S + + L++ TQ D+G Y+C+ SN +L PPS
Sbjct: 1198 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS 1254
Query: 313 -----ASAYLTVL-CMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
+ VL + C V +P P L +W KDG+ L + +G L+
Sbjct: 1255 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVLL 1310
Query: 366 IAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGRELL 421
L N + G YSC N++G VLL AP + EE V +
Sbjct: 1311 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPIS 1369
Query: 422 IPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVAR 478
+ C A P P ++W K G + + L + KE G + C +N +
Sbjct: 1370 LICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE 1429
Query: 479 VATSTNVYVL 488
+ +V VL
Sbjct: 1430 AVKNYHVEVL 1439
Score = 101 bits (252), Expect = 4e-21
Identities = 121/434 (27%), Positives = 177/434 (40%), Gaps = 59/434 (13%)
Query: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150
A LQ++ V D G Y C L+Q + N L V P F L V+E
Sbjct: 933 ALLQVDRADVWDAGHYTCEA--LNQAGRSEKHYN-----LNVWVAPVFPLRESHTLTVRE 985
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207
P +L C RG P P ++W+ G+ L G+G G V L + + + G YTC+
Sbjct: 986 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 1045
Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264
S+ G+++ QL V PP I P + T V+ QD +L C+A P T +W +D
Sbjct: 1046 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 1104
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSA 313
V LQ + + SL + Q G Y+CV N +L PP
Sbjct: 1105 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1161
Query: 314 SAYL-------TVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366
L L P + C PP + W + + + PG E + ++
Sbjct: 1162 IGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYLL 1211
Query: 367 ALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV-G 417
A G E G YSC N G A + VL+ PP+ EE + + G
Sbjct: 1212 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDG 1269
Query: 418 RELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSASN 474
+ + C+ G P P ++W K GR L +G A S ++L+ L + GH+ C A+N
Sbjct: 1270 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1329
Query: 475 AVARVATSTNVYVL 488
AV + VL
Sbjct: 1330 AVGEKTKHFQLSVL 1343
Score = 100 bits (249), Expect = 8e-21
Identities = 142/551 (25%), Positives = 216/551 (39%), Gaps = 63/551 (11%)
Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146
+ G L+I G V D+G Y+C V F DF L V++PP + +
Sbjct: 269 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 321
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205
V E V L C ARG P P++TW G L V + G L++ R + +GVYT
Sbjct: 322 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 381
Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262
C+AS+ G+A AT+L V PP I P A + V+L C A +P+ T SW
Sbjct: 382 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 440
Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN---------------- 305
+ + V + R+ DGS LRL + +G Y+CV S+
Sbjct: 441 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 496
Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGK-ALQLDKFPGWSQGTEGS 363
LL T++ P + C + P+ + W ++G+ A +L SQGT +
Sbjct: 497 PQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGT--T 553
Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423
L I D G ++C N GTAG V + P +E P +Y P
Sbjct: 554 LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFP 613
Query: 424 CS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-----HGHW 468
+ A PP V W G L G+ + + PL E G +
Sbjct: 614 AACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 672
Query: 469 ECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYT 528
C+A+N + VL P++ A+ + A+V+ E G S W+
Sbjct: 673 TCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVS-WF- 729
Query: 529 PLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAP 587
+ + W+ + V V L + Q + +A N GS + ++ P
Sbjct: 730 ----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP 785
Query: 588 EGLPTTPAAPG 598
+ P+ PG
Sbjct: 786 PRITLPPSLPG 796
Score = 95.5 bits (236), Expect = 3e-19
Identities = 131/517 (25%), Positives = 201/517 (38%), Gaps = 77/517 (14%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70
V+ + + P+++ G + ++G L P A P+ I+WL+ G
Sbjct: 486 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 536
Query: 71 GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130
R + G +G +L I+ + ++ G + C+ + G+ V +
Sbjct: 537 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 584
Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173
+V+ E P VLEV + C V RG P P + W
Sbjct: 585 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 639
Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231
G G+ G + L+I +V+ G+YTC A++ G + L VL PP I
Sbjct: 640 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 699
Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290
P N V + V+L C A P SWF+ + V V + VDG LR+
Sbjct: 700 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 754
Query: 291 TQPDDAGCYTCVPSN---------GL-LHPPSASAYLTVLCMPGVIRCPVR-----ANPP 335
Q DAG Y CV SN GL ++ P L P ++ PVR P
Sbjct: 755 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 814
Query: 336 LLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPVT 394
+ W KDG + PG G L +A G YSC +++G V
Sbjct: 815 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 874
Query: 395 RVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNS 453
+V + PP+ + +E V E + + C + PPPV+SW K GR L+ + V ++
Sbjct: 875 QVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 930
Query: 454 SLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 487
L + + GH+ C A N R N+ V
Sbjct: 931 DKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNV 967
Score = 94.4 bits (233), Expect = 6e-19
Identities = 128/513 (24%), Positives = 195/513 (38%), Gaps = 83/513 (16%)
Query: 16 QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75
Q A R P VSVV L C+ G+PP + W R G P+ + GL
Sbjct: 1066 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 1114
Query: 76 RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134
+LQ +G SL +E + G Y C L L+V
Sbjct: 1115 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 1157
Query: 135 PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191
PP+ P + P+TL C A G P P + W + + G+ + G L
Sbjct: 1158 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 1217
Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249
++ + + SG+Y+C AS+ G A + VL PP I + Q L C+
Sbjct: 1218 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1277
Query: 250 AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303
+P +WF+D + HIS DG L ++L AG Y+C+
Sbjct: 1278 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 1327
Query: 304 SNGLLHPPSASAYLTVLCMPGVI---------RCPVRANPPLLFV-----------SWTK 343
+N + + L+VL P ++ V N P+ + +W K
Sbjct: 1328 ANAV-GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1386
Query: 344 DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
DG + + GT G I+ EDA G+Y+C N LG A + VL+ PP+
Sbjct: 1387 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 1443
Query: 404 FI------ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 455
E +E +V L + C + PPP + W K G+ + + QV L
Sbjct: 1444 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 1503
Query: 456 I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 487
+ ++P G + C A+N NV +
Sbjct: 1504 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1536
Score = 92.8 bits (229), Expect = 2e-18
Identities = 114/432 (26%), Positives = 163/432 (37%), Gaps = 55/432 (12%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147
G L+IE ++ D G Y C + A + + L VN PP+ P
Sbjct: 747 GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 797
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204
V PV L C A G+P P + W G + G +QV G L + SG Y
Sbjct: 798 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 857
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
+C A S G L V PP I+ N +V A++ V+L C + A P + SW++D
Sbjct: 858 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 916
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSN---------------G 306
L+PR + + LL DAG YTC N
Sbjct: 917 G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVA 970
Query: 307 LLHPPSASAYLTVL-CMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG--- 362
+ P S LTV P + C R P +SW KDG+ L PG G +
Sbjct: 971 PVFPLRESHTLTVREGHPTSLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHVSA 1024
Query: 363 -SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
++ LG G Y+C N +G + V + A P +
Sbjct: 1025 VGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV 1084
Query: 420 LLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASNAV 476
+ C+A G PPP V+W + G+ G + Q+ + + + AH G + C A N
Sbjct: 1085 ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLA 1144
Query: 477 ARVATSTNVYVL 488
R + VL
Sbjct: 1145 GRAERKFELSVL 1156
Score = 81.6 bits (200), Expect = 4e-15
Identities = 189/772 (24%), Positives = 269/772 (34%), Gaps = 158/772 (20%)
Query: 145 VLEVQELEPVTLR-------CVARGSPLPHVTWKL--RGKDLGQGQGQVQVQNGTLRIRR 195
VLE++ L V L C G+P P VTW+ + L G ++ G+L +
Sbjct: 4 VLEIKGLGDVALTVGLEAGGCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLAS 63
Query: 196 VERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVSLACHAEAY 253
V SG Y CQA++ GS + +L+V PP I + + V+ A Q ++L C A +
Sbjct: 64 VSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGF 123
Query: 254 P---------ANLT--------YSW-----------FQDNINVFHISRLQP----RVRIL 281
P A L Y W D H R+QP R
Sbjct: 124 PVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQ 183
Query: 282 VDGSLRLLATQPDDAGCYTCVPSNGLLHPPS------ASAYLTVLCMPGV---IRCPVRA 332
GS + A + P+ PP+ A A VL + G ++C +
Sbjct: 184 AGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQC-WTS 242
Query: 333 NPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNE-DALGEYSCTPYNSLGTAGPS 391
P V WTKD + + L P +G ++ G+ G Y C ++ G
Sbjct: 243 GVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD 301
Query: 392 PVTRVLLKAPPAFIERPKEEYFQEVGRELLIP--CSAQGDPPPVVSWTKVGRGLQGQAQV 449
RV APP I E V + L+ C A+G P P ++W K G L +V
Sbjct: 302 FQLRV--HAPPT-IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKV 358
Query: 450 ---DSNSSLILRPLTKEAHGHWECSASNAV--ARVATSTNVYVLGTSPHVVTNVSVVALP 504
L L G + C ASNAV A AT +VYV T VV
Sbjct: 359 VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV 418
Query: 505 KGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY 564
G V+ E G S W HH+ +PV ++ + +
Sbjct: 419 AGRPVALECVARGHPSPTLS-W-----------HHE----GLPVAESN------ESRLET 456
Query: 565 QFSVL---AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPR 621
SVL + + SG +S V S+P G + ++PP L GL V T
Sbjct: 457 DGSVLRLESPGEASSGLYS-CVASSPAGEAVLQYS---VEVQVPPQLLVAEGLGQVTTIV 512
Query: 622 GVLLHWDPPELVPKRLDGYVLEGRQ----GSQGWEVLDPAVAGTETELLVPGLIKDVLYE 677
G P EL P + G + Q G E+ VA T L + + D
Sbjct: 513 G-----QPLEL-PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELD---- 562
Query: 678 FRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVS 737
+G F +N A + + +EV PG+L P+ G G S
Sbjct: 563 -----HSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI------GQYHWGXEHHSS 611
Query: 738 ILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPS 797
A C DPP+ P G SP S
Sbjct: 612 FPAAC-----------------DPPVHRGWGAHPKPPLVEGWCSPGS------------- 641
Query: 798 LRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQER 849
LWG+P G P + PP PL +E + +G + T A + +
Sbjct: 642 -----LWGEPTGIPVAYSLPP----PLQIEKVDLRDEGIYTCAATNLAGESK 684
Score = 63.9 bits (154), Expect = 8e-10
Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142
R +LQ G SL I +D G Y+C + E++ V + V S P FQ
Sbjct: 3074 RHQLQNG-SLTIHRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 3123
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
P + V+ + V LRC A G P P + W G+ L + + +G+L + VE G +G
Sbjct: 3124 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3183
Query: 203 VYTCQASSTEGSATHATQLLVLGPP 227
Y C A + GSAT L+V G P
Sbjct: 3184 TYDCVAHNLLGSATARAFLVVRGEP 3208
Score = 56.2 bits (134), Expect = 2e-07
Identities = 97/438 (22%), Positives = 156/438 (35%), Gaps = 70/438 (15%)
Query: 93 LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP----AVLE 147
LQI + ED G Y C V L + + H+ V PP + P V E
Sbjct: 1406 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLGEVGVKE 1457
Query: 148 VQEL--EPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204
V+ +TL C + P P + W G+ + QV + L+I+ + SG Y
Sbjct: 1458 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 1517
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244
C A++ G +L+ PP+ S + +
Sbjct: 1518 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1577
Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303
L C A P +W++++ + V +L G L++ + ++AG Y+C
Sbjct: 1578 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 1632
Query: 304 SNG-----------LLHPP-------SASAYLTVLCMPGV-IRCPVRANPPLLFVSWTKD 344
SN +L PP +TV V ++CP N P+ +SW ++
Sbjct: 1633 SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTISWLQN 1691
Query: 345 GKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
G L P +G ++ ++ Y C N G+A RV + PP
Sbjct: 1692 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPR 1747
Query: 404 FIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPL 460
E+ + + +PC P P V+W K + L +V +L L
Sbjct: 1748 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1807
Query: 461 TKEAHGHWECSASNAVAR 478
G + C A NA R
Sbjct: 1808 RLSDSGMYTCEALNAAGR 1825
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 125 bits (313), Expect = 3e-28
Identities = 133/492 (27%), Positives = 191/492 (38%), Gaps = 63/492 (12%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86
VVG A +VL C + P I W R G +L QF
Sbjct: 3591 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 3631
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144
++G LQ++ L D G Y C + A + V + +++ P + PPA
Sbjct: 3632 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 3681
Query: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203
V V + L C A G P P V+W+ L + ++ G+LRI+ V +G
Sbjct: 3682 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 3740
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
Y C AS++ GS L VL PP I P N T+ A L C A P L W
Sbjct: 3741 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 3800
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL----------LHPPSA 313
F + Q R+L +L L A P D+ + CV SN + +H P
Sbjct: 3801 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 3858
Query: 314 SA-----YLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368
A + + P V+ C P VSW+K G L + G+ G+L I
Sbjct: 3859 IADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEIGQ 3916
Query: 369 GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPCSAQ 427
G Y+C+ NS G A V L + + +P + V E+L+PC A
Sbjct: 3917 ALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 3972
Query: 428 GDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485
G P P ++W K G + QV L + + E G++ C A N+ T +
Sbjct: 3973 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 4032
Query: 486 YVLGTSPHVVTN 497
V P V+ N
Sbjct: 4033 VV--QVPPVIEN 4042
Score = 116 bits (290), Expect = 1e-25
Identities = 109/386 (28%), Positives = 161/386 (41%), Gaps = 37/386 (9%)
Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
V LTV + P + P V V E E V L C A G P P +TW+ G ++ G +
Sbjct: 3940 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 3998
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
G LRI +G Y C A ++ GSA T+L+V PPVI + + L
Sbjct: 3999 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 4058
Query: 248 CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
C A P N+T W +D V S + + I G L + + DAG YTC N
Sbjct: 4059 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 4113
Query: 307 LLHPPSASAYLTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQL 350
+ +LT+L +P +RC R +P + WT + + +
Sbjct: 4114 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 4170
Query: 351 DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408
G S+ GS + A+ ED+ G Y C N +G V+ V +K P
Sbjct: 4171 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 4224
Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 466
+ VG + + C +GDP P + W K G L+G N SL + ++ G
Sbjct: 4225 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAG 4284
Query: 467 HWECSASNAVARVATSTNVYVLGTSP 492
++C A N + VA + VL ++P
Sbjct: 4285 RYQCLAENEMG-VAKKVVILVLQSAP 4309
Score = 113 bits (283), Expect = 9e-25
Identities = 140/526 (26%), Positives = 199/526 (37%), Gaps = 102/526 (19%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G S +L C GRPP + W R G P+ ++ G R R L
Sbjct: 800 GRSALLACRA---TGRPP-PTVTWRR-GDGQPLGLRLGAGRG-------SRSRQPDSGVL 847
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
E + EDQ Y C + + + + + +T ++PPQ + P V V E +P
Sbjct: 848 FFESVAPEDQAPYVCEARNVFGKVQAE-----ARLIVTGHAPPQIASSAPTV-RVLEGQP 901
Query: 154 VTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTE 212
V+L C+ G PLP W G+ L G +G+L + R + +G Y+C A++T
Sbjct: 902 VSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTA 961
Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV---- 268
GS +L+V PP I + N SL C A PA T +W ++ +
Sbjct: 962 GSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP-TITWTKETNALTSRG 1020
Query: 269 --FHISR------LQPRVR--------------------------------------ILV 282
+++S+ QP + +L
Sbjct: 1021 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLP 1080
Query: 283 DGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSAS---AYLTVLCMPGV-IR 327
GSLRL Q D+G Y C SN G+ PP L VL + +
Sbjct: 1081 SGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLN 1140
Query: 328 CPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLG 386
C NP P L SW+KDG LQ +G +GS+ A G Y C NS G
Sbjct: 1141 CVAEGNPEPQL--SWSKDGVVLQ-------GRGPQGSVHFAAIRTSDAGRYRCEASNSAG 1191
Query: 387 TAGPSPVTRVLLKAPPAFIERPKEEYFQEV-GRELLIPCSAQGDPPPVVSWTK--VGRGL 443
RVL PP + + V G +PC A+G P P V+W K L
Sbjct: 1192 VDAWEVELRVL--EPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPL 1249
Query: 444 QGQ--AQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 487
GQ V SL L ++ G +EC A+N V + + V
Sbjct: 1250 HGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295
Score = 108 bits (271), Expect = 2e-23
Identities = 137/493 (27%), Positives = 192/493 (38%), Gaps = 53/493 (10%)
Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
+V G AG+S+ L CD A P+ I WL+ L+ + + + Y + VG RL
Sbjct: 1309 NVSGMAGQSLTLECD----ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 1364
Query: 88 -QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146
+G SL ++ D G Y CR + DF HL V +PP A
Sbjct: 1365 LDEGQSLHFPRIQEGDSGLYSCRAEN-QAGTAQRDF------HLLVLTPPSVLGAG-AAQ 1416
Query: 147 EVQELE--PVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSG 202
EV L V L+C G P P V W + + G +QVQ LRI G G
Sbjct: 1417 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 1476
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQD--VSLACHAEAYPA-NLTY 259
Y C A S G QL V PP I + V +D V L C A P N+T
Sbjct: 1477 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT- 1535
Query: 260 SWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------LL 308
WF+D + +++ V L+L Q DAG YTC SN +
Sbjct: 1536 -WFKDGALLPTSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 1591
Query: 309 HPPSAS-------AYLTVLCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGT 360
PP+ V P + C R +P P L SW +G L + + T
Sbjct: 1592 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEG--LPVAESNESRLET 1647
Query: 361 EGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
+GS++ + E + G YSC + G A V + P + + VG+
Sbjct: 1648 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV-PPQLLVAEGLGQVTTIVGQP 1706
Query: 420 LLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 476
L +PC A G P P + W + GR L G ++L + + + G + C A+N
Sbjct: 1707 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 1766
Query: 477 ARVATSTNVYVLG 489
V V G
Sbjct: 1767 GTAGAEVEVSVHG 1779
Score = 108 bits (270), Expect = 3e-23
Identities = 121/487 (24%), Positives = 190/487 (39%), Gaps = 64/487 (13%)
Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
P VV V A E V+L C+ A P I W + G + +
Sbjct: 3954 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 3993
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142
++ G L+I ED G Y C I ++ + L V PP +
Sbjct: 3994 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 4044
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201
P L E L C ARGSP P++TW G+ + +G+ +Q +G L ++ +E +
Sbjct: 4045 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 4103
Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261
G YTC A + G A L +L PV P + ++ + L C A P
Sbjct: 4104 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 4163
Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSAS------- 314
D +S +L+ A +D+G Y C N + + S
Sbjct: 4164 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 4217
Query: 315 --------AYLTVLCMPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364
+YL V + G I+ C VR +P + + W KDG L+ Q GSL
Sbjct: 4218 PVLQGEAFSYL-VEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSL 4273
Query: 365 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424
I D G Y C N +G A V ++L++ P F P++ + G ++ + C
Sbjct: 4274 TIHRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 4330
Query: 425 SAQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATS 482
A G+P P + W + G+ L+ ++ + + SL L + G ++C A N +
Sbjct: 4331 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 4390
Query: 483 TNVYVLG 489
+ V G
Sbjct: 4391 AFLVVRG 4397
Score = 108 bits (269), Expect = 4e-23
Identities = 119/448 (26%), Positives = 180/448 (40%), Gaps = 63/448 (14%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139
L +G LQI+ +V D G Y C + +D ++ + PP FQ
Sbjct: 2689 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 2741
Query: 140 ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
E V E +E+ P L C P P +TW + L G +Q
Sbjct: 2742 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 2801
Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242
G L+I V ++G Y+C+AS+ G +LLVL PPVI+ + TVNAS
Sbjct: 2802 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 2861
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301
VSL C A P T SW Q+ + PR+++L DG L++ + DA Y C
Sbjct: 2862 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 2916
Query: 302 VPSN-----------GLLHPPSASA----YLTVLCMPGV-IRCPVRANPPLLFVSWTKDG 345
V N + PP + +T + V + C V A+P V+W KD
Sbjct: 2917 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWYKDS 2975
Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
+AL L + GT +L + G Y+C N+ G + ++ + PPAF
Sbjct: 2976 QALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPPAFR 3032
Query: 406 ERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRP 459
+ P+ + VG + ++ C P P V+W K G+ L Q + L ++
Sbjct: 3033 QAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 3092
Query: 460 LTKEAHGHWECSASNAVARVATSTNVYV 487
G + C SN + + V
Sbjct: 3093 AQVSDKGLYSCKVSNVAGEAVRTFTLTV 3120
Score = 106 bits (264), Expect = 1e-22
Identities = 111/419 (26%), Positives = 166/419 (39%), Gaps = 45/419 (10%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R+ + +L I+G+ ED G Y C+ + + V L PP
Sbjct: 653 RIHVDAQGTLIIQGVAPEDAGNYSCQA-------TNEVGTDQETVTLYYTDPPSVSAVNA 705
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQG-QGQVQVQNGTLRIRRVERGSSG 202
VL V E L C A G P P V W G ++ +G +G LRI + +G
Sbjct: 706 VVL-VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---SSGKLRIPAAQERDAG 761
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262
YTC+A + G A+ QL V P + P++ TV + LAC A P T +W
Sbjct: 762 TYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP-TVTWR 820
Query: 263 QDNINVFHI---SRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-------------- 305
+ + + + R R G L + P+D Y C N
Sbjct: 821 RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 880
Query: 306 GLLHPPSASAYLTVLCMPGV---IRCPVRANPPLLFVSWTKDGKALQLDKFPG--WSQGT 360
G P AS+ TV + G + C V A PL W KDG+ L PG S
Sbjct: 881 GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP----PGSRHSIRA 936
Query: 361 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420
+GSL + ++ G YSC N+ G+ ++++ PP I + G
Sbjct: 937 DGSLHLDRALQEHAGRYSCVATNTAGSQHRD--VELVVQVPPR-IHPTATHHITNEGVPA 993
Query: 421 LIPCSAQGDPPPVVSWTKVGRGLQGQA---QVDSNSSLILRPLTKEAHGHWECSASNAV 476
+PC A G P P ++WTK L + V +L++ + + G + C+A+N V
Sbjct: 994 SLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 1052
Score = 106 bits (264), Expect = 1e-22
Identities = 145/506 (28%), Positives = 211/506 (41%), Gaps = 81/506 (16%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92
G+ V L C+ G+PP V WL+ G SP + D +R G S
Sbjct: 3232 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 3274
Query: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150
L ++GLR D G Y C H P + A V++ V PP ++ L +
Sbjct: 3275 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 3327
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209
E VT+ C RGSP HV+W G L Q + +G TLRI +V+ +G++TC A+
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 3387
Query: 210 STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
S G A L V PPV+ V + V V L C A P L SW +D
Sbjct: 3388 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 3446
Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPP--SAS 314
+ S Q SL+L A D+G Y+CV + ++ PP S
Sbjct: 3447 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 3499
Query: 315 AYLTVLCM----PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGN 370
T L + P + C + P ++W KDG+A L + S+ T L
Sbjct: 3500 GQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLRV 3551
Query: 371 EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSAQ 427
DA G Y+C + G S RV ++APP + P+ F VG +L++ CS +
Sbjct: 3552 RDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSVE 3606
Query: 428 GDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 484
+P P ++W + G LQ A + L L+ L+ G + C+A NA + +
Sbjct: 3607 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666
Query: 485 VYVLGTSPHVVTNVSVVALPKGANVS 510
V + H V + + P NVS
Sbjct: 3667 VEI-----HTVPTIR--SGPPAVNVS 3685
Score = 103 bits (257), Expect = 1e-21
Identities = 137/498 (27%), Positives = 188/498 (37%), Gaps = 76/498 (15%)
Query: 26 VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85
V V A +V L C PA P+ I WL+ G LP SPR+
Sbjct: 2852 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 2894
Query: 86 RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140
L+ G LQ+ V D Y C + E+ + + L V PP+ E
Sbjct: 2895 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 2945
Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198
A+L V+L C P P VTW + L G+ +V + GT L++ R
Sbjct: 2946 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 3000
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254
SG+YTC+A + G QL VL PP P+ V L+C +A P
Sbjct: 3001 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 3060
Query: 255 ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-------- 305
T +W++D + L R + L G L + Q D G Y+C SN
Sbjct: 3061 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRT 3115
Query: 306 --------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-W 356
P V P V+ C V + P V+W KD ++ G
Sbjct: 3116 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGVV 3174
Query: 357 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 416
S+G G L ++ G Y+C N+ A V VL+ AP E+
Sbjct: 3175 SRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVLE 3231
Query: 417 GRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWEC 470
G+E+ + C A G PPP V+W K G L GQ SL+L+ L G + C
Sbjct: 3232 GQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 3290
Query: 471 SASNAVARVATSTNVYVL 488
A N A V VL
Sbjct: 3291 VAHNPAGEDARLHTVNVL 3308
Score = 103 bits (256), Expect = 1e-21
Identities = 120/434 (27%), Positives = 175/434 (40%), Gaps = 59/434 (13%)
Query: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150
A LQ++ V D G Y C H E + WV P F L V+E
Sbjct: 2124 ALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNVWV------APVFPLRESHTLTVRE 2176
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207
P +L C RG P P ++W+ G+ L G+G G V L + + + G YTC+
Sbjct: 2177 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 2236
Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264
S+ G+++ QL V PP I P + T V+ QD +L C+A P T +W +D
Sbjct: 2237 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 2295
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSA 313
V LQ + + SL + Q G Y+CV N +L PP
Sbjct: 2296 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 2352
Query: 314 SAYL-------TVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366
L L P + C PP + W + + + PG E + ++
Sbjct: 2353 IGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYLL 2402
Query: 367 ALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV-G 417
A G E G YSC N G A + VL+ PP+ EE + + G
Sbjct: 2403 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDG 2460
Query: 418 RELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSASN 474
+ + C+ G P P ++W K GR L +G A S ++L+ L + GH+ C A+N
Sbjct: 2461 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 2520
Query: 475 AVARVATSTNVYVL 488
AV + VL
Sbjct: 2521 AVGEKTKHFQLSVL 2534
Score = 102 bits (254), Expect = 2e-21
Identities = 221/888 (24%), Positives = 320/888 (36%), Gaps = 153/888 (17%)
Query: 14 ISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLY 73
+ G G + + G A VLG + PP +P V++ L L + G
Sbjct: 1089 VQVGDSGHYECTASNPAGSASHRYVLGVQV-PPQVQPGPRVLKVLVGEALDLNCVAEGNP 1147
Query: 74 SPRIDPDYVGRVRLQKG--ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHL 130
P++ G V +G S+ +R D G Y C + +W V L
Sbjct: 1148 EPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEA--------SNSAGVDAWEVEL 1199
Query: 131 TVNSPPQF-QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKL--RGKDLGQGQGQVQVQ 187
V PP + + +LE E +L C ARG+P P VTW+ + L G ++
Sbjct: 1200 RVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLE 1259
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVS 245
G+L + V SG Y CQA++ GS + +L+V PP I + + V+ A Q ++
Sbjct: 1260 EGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLT 1319
Query: 246 LACHAEAYPANLTYSWFQDNINV----------FHISRLQPRVRILVD--GSLRLLATQP 293
L C A +P W +D V + + Q L+D SL Q
Sbjct: 1320 LECDANGFPVP-EIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQE 1378
Query: 294 DDAGCYTCVPSNG-----------LLHPPS---ASAYLTVLCMPGV---IRCPVRANPPL 336
D+G Y+C N +L PPS A A VL + G ++C + P
Sbjct: 1379 GDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQC-WTSGVPT 1437
Query: 337 LFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNE-DALGEYSCTPYNSLGTAGPSPVTR 395
V WTKD + + L P +G ++ G+ G Y C ++ G R
Sbjct: 1438 PQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLR 1496
Query: 396 VLLKAPPAFIERPKEEYFQEVGRELLIP--CSAQGDPPPVVSWTKVGRGLQGQAQV---D 450
V APP I E V + L+ C A+G P P ++W K G L +V
Sbjct: 1497 V--HAPPT-IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTR 1553
Query: 451 SNSSLILRPLTKEAHGHWECSASNAV--ARVATSTNVYVLGTSPHVVTNVSVVALPKGAN 508
L L G + C ASNAV A AT +VYV T VV G
Sbjct: 1554 GGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRP 1613
Query: 509 VSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 568
V+ E G S W HH+ +PV ++ + + SV
Sbjct: 1614 VALECVARGHPSPTLS-W-----------HHE----GLPVAESN------ESRLETDGSV 1651
Query: 569 L---AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLL 625
L + + SG +S V S+P G + ++PP L GL V T G
Sbjct: 1652 LRLESPGEASSGLYS-CVASSPAGEAVLQYS---VEVQVPPQLLVAEGLGQVTTIVG--- 1704
Query: 626 HWDPPELVPKRLDGYVLEGRQ----GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLV 681
P EL P + G + Q G E+ VA T L + + D
Sbjct: 1705 --QPLEL-PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELD-------- 1753
Query: 682 AFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAG 741
+G F +N A + + +EV PG+L P+ G G S A
Sbjct: 1754 -HSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI------GQYHWGXEHHSSFPAA 1806
Query: 742 CLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQS 801
C DPP+ P G SP S
Sbjct: 1807 C-----------------DPPVHRGWGAHPKPPLVEGWCSPGS----------------- 1832
Query: 802 LLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQER 849
LWG+P G P + PP PL +E + +G + T A + +
Sbjct: 1833 -LWGEPTGIPVAYSLPP----PLQIEKVDLRDEGIYTCAATNLAGESK 1875
Score = 102 bits (253), Expect = 3e-21
Identities = 113/430 (26%), Positives = 172/430 (40%), Gaps = 47/430 (10%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147
G L + ++ +G Y C + + +D + L V+ PPQ PP +
Sbjct: 2217 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 2269
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206
V + TL C A G P P VTW+ G+ +G G Q+Q Q +L + R + +G Y+C
Sbjct: 2270 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 2329
Query: 207 QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
A + G A +L VL PP ++ P N T ++L C A P WF+
Sbjct: 2330 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 2388
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312
V S + + L++ TQ D+G Y+C+ SN +L PPS
Sbjct: 2389 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS 2445
Query: 313 -----ASAYLTVL-CMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
+ VL + C V +P P L +W KDG+ L + +G L+
Sbjct: 2446 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVLL 2501
Query: 366 IAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGRELL 421
L N + G YSC N++G VLL AP + EE V +
Sbjct: 2502 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPIS 2560
Query: 422 IPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVAR 478
+ C A P P ++W K G + + L + KE G + C +N +
Sbjct: 2561 LICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE 2620
Query: 479 VATSTNVYVL 488
+ +V VL
Sbjct: 2621 AVKNYHVEVL 2630
Score = 100 bits (249), Expect = 8e-21
Identities = 142/551 (25%), Positives = 216/551 (39%), Gaps = 63/551 (11%)
Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146
+ G L+I G V D+G Y+C V F DF L V++PP + +
Sbjct: 1460 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 1512
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205
V E V L C ARG P P++TW G L V + G L++ R + +GVYT
Sbjct: 1513 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 1572
Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262
C+AS+ G+A AT+L V PP I P A + V+L C A +P+ T SW
Sbjct: 1573 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 1631
Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN---------------- 305
+ + V + R+ DGS LRL + +G Y+CV S+
Sbjct: 1632 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 1687
Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGK-ALQLDKFPGWSQGTEGS 363
LL T++ P + C + P+ + W ++G+ A +L SQGT +
Sbjct: 1688 PQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGT--T 1744
Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423
L I D G ++C N GTAG V + P +E P +Y P
Sbjct: 1745 LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFP 1804
Query: 424 CS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-----HGHW 468
+ A PP V W G L G+ + + PL E G +
Sbjct: 1805 AACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 1863
Query: 469 ECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYT 528
C+A+N + VL P++ A+ + A+V+ E G S W+
Sbjct: 1864 TCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVS-WF- 1920
Query: 529 PLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAP 587
+ + W+ + V V L + Q + +A N GS + ++ P
Sbjct: 1921 ----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP 1976
Query: 588 EGLPTTPAAPG 598
+ P+ PG
Sbjct: 1977 PRITLPPSLPG 1987
Score = 97.1 bits (240), Expect = 9e-20
Identities = 105/367 (28%), Positives = 151/367 (41%), Gaps = 44/367 (11%)
Query: 152 EPVTLRCVARGSPLPHVTWKLRGKD-LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASS 210
+P+ + C S LP RG+ LG+ + + N + I R + G Y C A S
Sbjct: 442 QPLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 500
Query: 211 TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACH--AEAYPANLTYSWFQDNINV 268
G+ Q++V PP +VP N TV+ + L+C EA P NLT W +D
Sbjct: 501 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA-PYNLT--WVRD---- 553
Query: 269 FHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPG 324
R+ P RV L D SL + P D G Y CV SN AS +L V P
Sbjct: 554 ---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA-NGVTRASVWLLVREAPQ 609
Query: 325 V----------------IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII-A 367
V + C + P +SW+++ +ALQ D +G+LII
Sbjct: 610 VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDS--RIHVDAQGTLIIQG 666
Query: 368 LGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQ 427
+ EDA G YSC N +GT T L P + VG E ++ C A
Sbjct: 667 VAPEDA-GNYSCQATNEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 722
Query: 428 GDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 487
G PPP V W + G + + S+ L + + G + C A N + + + V
Sbjct: 723 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 782
Query: 488 LGTSPHV 494
G +P +
Sbjct: 783 -GHAPQL 788
Score = 96.7 bits (239), Expect = 1e-19
Identities = 138/535 (25%), Positives = 194/535 (36%), Gaps = 86/535 (16%)
Query: 14 ISQGADGRGKPEVV------------SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFG 61
+S+ GR K ++V +V GE+ VL C +L G P + + W+R
Sbjct: 499 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL---GEAPYN-LTWVR-- 552
Query: 62 FLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDD 121
R+ P GRV SL+I G+ D G Y+C
Sbjct: 553 ------------DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA----------S 590
Query: 122 FANG---SWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG 178
ANG + V L V PQ + Q +E V + C A G P PH++W + L
Sbjct: 591 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQAL- 648
Query: 179 QGQGQVQVQ-NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNST 237
Q ++ V GTL I+ V +G Y+CQA++ G+ L PP +
Sbjct: 649 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 708
Query: 238 VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAG 297
V ++ L C A P W++ + + L P G LR+ A Q DAG
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMI----LAPEGS--SSGKLRIPAAQERDAG 761
Query: 298 CYTCVPSNGLLHPPSASAYLTV----------------LCMPGVIRCPVRANPPLLFVSW 341
YTC N L SA L V L ++ C PP V+W
Sbjct: 762 TYTCRAVNE-LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTW 819
Query: 342 TK-DGKALQLDKFPGWS----QGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396
+ DG+ L L G Q G L + Y C N G V
Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879
Query: 397 LLKAPPAFIERPKEEYFQEVGRELLIPCSA-QGDPPPVVSWTKVGRGLQ--GQAQVDSNS 453
APP E G+ + +PC G P P W K GR L + + ++
Sbjct: 880 TGHAPPQIASSAPTVRVLE-GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 938
Query: 454 SLILRPLTKEAHGHWECSASNAVARVATSTNVYVL------GTSPHVVTNVSVVA 502
SL L +E G + C A+N + V T+ H +TN V A
Sbjct: 939 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPA 993
Score = 95.1 bits (235), Expect = 3e-19
Identities = 112/392 (28%), Positives = 153/392 (39%), Gaps = 65/392 (16%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH---LTVNSPPQFQETPP 143
L SL++ ++V D G YEC GS H L V PPQ Q P
Sbjct: 1078 LLPSGSLRLAQVQVGDSGHYECTA----------SNPAGSASHRYVLGVQVPPQVQ-PGP 1126
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGV 203
VL+V E + L CVA G+P P ++W G L QG+G G++ + +G
Sbjct: 1127 RVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVL-QGRG----PQGSVHFAAIRTSDAGR 1181
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVN--ASQDVSLACHAEAYPANLTYSW 261
Y C+AS++ G +L VL PP + + A ++ SL C A P
Sbjct: 1182 YRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWR 1241
Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLC 321
+ H QP V +L +GSL L + P D+G Y C +N + S A L V
Sbjct: 1242 KGPSSEPLH---GQPGVAVLEEGSLFLASVSPADSGDYECQATNE-VGSTSRRAKLVVYV 1297
Query: 322 MPGVIRCPVRANP-----------------PLLFVSWTKDGKALQLDKFP------GWSQ 358
P + +AN P+ + W KD QL P GW
Sbjct: 1298 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA---QLVGVPLGWAGYGWDL 1354
Query: 359 G----------TEG-SLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI-E 406
G EG SL E G YSC N GTA +L+ PP+ +
Sbjct: 1355 GWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRD--FHLLVLTPPSVLGA 1412
Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTK 438
+E G ++ + C G P P V WTK
Sbjct: 1413 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444
Score = 94.4 bits (233), Expect = 6e-19
Identities = 115/432 (26%), Positives = 163/432 (37%), Gaps = 55/432 (12%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147
G L+IE ++ D G Y C + A + + L VN PP+ P
Sbjct: 1938 GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 1988
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204
V PV L C A G+P P + W G + G +QV G L + SG Y
Sbjct: 1989 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 2048
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
+C A S G L V PP I+ N +V A++ V+L C + A P + SW++D
Sbjct: 2049 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 2107
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSNGLLH------------ 309
L+PR + + LL DAG YTC N H
Sbjct: 2108 G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA 2161
Query: 310 ---PPSASAYLTVL-CMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG--- 362
P S LTV P + C R P +SW KDG+ L PG G +
Sbjct: 2162 PVFPLRESHTLTVREGHPTSLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHVSA 2215
Query: 363 -SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
++ LG G Y+C N +G + V + A P +
Sbjct: 2216 VGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV 2275
Query: 420 LLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASNAV 476
+ C+A G PPP V+W + G+ G + Q+ + + + AH G + C A N
Sbjct: 2276 ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLA 2335
Query: 477 ARVATSTNVYVL 488
R + VL
Sbjct: 2336 GRAERKFELSVL 2347
Score = 94.4 bits (233), Expect = 6e-19
Identities = 128/513 (24%), Positives = 195/513 (38%), Gaps = 83/513 (16%)
Query: 16 QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75
Q A R P VSVV L C+ G+PP + W R G P+ + GL
Sbjct: 2257 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 2305
Query: 76 RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134
+LQ +G SL +E + G Y C L L+V
Sbjct: 2306 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 2348
Query: 135 PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191
PP+ P + P+TL C A G P P + W + + G+ + G L
Sbjct: 2349 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 2408
Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249
++ + + SG+Y+C AS+ G A + VL PP I + Q L C+
Sbjct: 2409 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 2468
Query: 250 AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303
+P +WF+D + HIS DG L ++L AG Y+C+
Sbjct: 2469 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 2518
Query: 304 SNGLLHPPSASAYLTVLCMPGVI---------RCPVRANPPLLFV-----------SWTK 343
+N + + L+VL P ++ V N P+ + +W K
Sbjct: 2519 ANAV-GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 2577
Query: 344 DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
DG + + GT G I+ EDA G+Y+C N LG A + VL+ PP+
Sbjct: 2578 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 2634
Query: 404 FI------ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 455
E +E +V L + C + PPP + W K G+ + + QV L
Sbjct: 2635 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 2694
Query: 456 I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 487
+ ++P G + C A+N NV +
Sbjct: 2695 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 2727
Score = 94.0 bits (232), Expect = 8e-19
Identities = 96/344 (27%), Positives = 141/344 (40%), Gaps = 50/344 (14%)
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
+G+LR+ +V+ G SG Y C AS+ GSA+H L V PP + P+ V + + L
Sbjct: 1081 SGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLN 1140
Query: 248 CHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG- 306
C AE P SW +D + LQ R GS+ A + DAG Y C SN
Sbjct: 1141 CVAEGNP-EPQLSWSKDGV------VLQGRG---PQGSVHFAAIRTSDAGRYRCEASNSA 1190
Query: 307 ----------LLHPPSASAYLTVLCMPGV------IRCPVRANPPLLFVSWTKDGKALQL 350
+L PP A T + V + CP R P V+W K + L
Sbjct: 1191 GVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQ-VTWRKGPSSEPL 1249
Query: 351 DKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE 410
PG + EGSL +A + G+Y C N +G+ S ++++ PP+ E ++
Sbjct: 1250 HGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST--SRRAKLVVYVPPSIREDGRK 1307
Query: 411 EYFQEV-GRELLIPCSAQGDPPPVVSWTK-----------VGRG-------LQGQAQVDS 451
+ G+ L + C A G P P + W K G G + G +D
Sbjct: 1308 ANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 1367
Query: 452 NSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVV 495
SL + + G + C A N ++ VL T P V+
Sbjct: 1368 GQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL-TPPSVL 1410
Score = 93.6 bits (231), Expect = 1e-18
Identities = 130/517 (25%), Positives = 200/517 (38%), Gaps = 77/517 (14%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70
V+ + + P+++ G + ++G L P A P+ I+WL+ G
Sbjct: 1677 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 1727
Query: 71 GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130
R + G +G +L I+ + ++ G + C+ + G+ V +
Sbjct: 1728 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 1775
Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173
+V+ E P VLEV + C V RG P P + W
Sbjct: 1776 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 1830
Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231
G G+ G + L+I +V+ G+YTC A++ G + L VL PP I
Sbjct: 1831 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 1890
Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290
P N V + V+L C A P SWF+ + V V + VDG LR+
Sbjct: 1891 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 1945
Query: 291 TQPDDAGCYTCVPSN---------GL-LHPPSASAYLTVLCMPGVIRCPVR-----ANPP 335
Q DAG Y CV SN GL ++ P L P ++ PVR P
Sbjct: 1946 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 2005
Query: 336 LLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPVT 394
+ W KDG + PG G L +A G YSC +++G V
Sbjct: 2006 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 2065
Query: 395 RVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNS 453
+V + PP+ + +E V E + + C + PPPV+SW K GR L+ + V ++
Sbjct: 2066 QVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 2121
Query: 454 SLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 487
L + + GH+ C A N N+ V
Sbjct: 2122 DKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 2158
Score = 92.4 bits (228), Expect = 2e-18
Identities = 131/490 (26%), Positives = 187/490 (38%), Gaps = 110/490 (22%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
V+ GE VL C+ +G PP VI W R G + +
Sbjct: 707 VLVAVGEEAVLVCEA---SGVPPPRVI-WYRGGLEM--------------------ILAP 742
Query: 89 KGAS---LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAV 145
+G+S L+I + D G Y CR + E A+ + L V PQ E P V
Sbjct: 743 EGSSSGKLRIPAAQERDAGTYTCRA------VNELGDASAE-IQLAVGHAPQLTELPRDV 795
Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKLR-----GKDLGQGQGQV--QVQNGTLRIRRVER 198
V+ L C A G P P VTW+ G LG G+G Q +G L V
Sbjct: 796 T-VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 854
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPAN 256
Y C+A + G +L+V G PP I V Q VSL C A
Sbjct: 855 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 914
Query: 257 LTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSN--GLLHP-- 310
W +D L P R I DGSL L + AG Y+CV +N G H
Sbjct: 915 PERHWLKDG------RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV 968
Query: 311 -----------PSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG 359
P+A+ ++T +P + C V + P ++WTK+ AL + P ++
Sbjct: 969 ELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALT-SRGPHYNVS 1026
Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
EG+L+IA + G Y CT N++G + V A ++ ++E G
Sbjct: 1027 KEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYV-------WEEYG-- 1077
Query: 420 LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARV 479
L+P + SL L + GH+EC+ASN
Sbjct: 1078 -LLP----------------------------SGSLRLAQVQVGDSGHYECTASNP---A 1105
Query: 480 ATSTNVYVLG 489
++++ YVLG
Sbjct: 1106 GSASHRYVLG 1115
Score = 63.9 bits (154), Expect = 8e-10
Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142
R +LQ G SL I +D G Y+C + E++ V + V S P FQ
Sbjct: 4265 RHQLQNG-SLTIHRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 4314
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
P + V+ + V LRC A G P P + W G+ L + + +G+L + VE G +G
Sbjct: 4315 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 4374
Query: 203 VYTCQASSTEGSATHATQLLVLGPP 227
Y C A + GSAT L+V G P
Sbjct: 4375 TYDCVAHNLLGSATARAFLVVRGEP 4399
Score = 56.2 bits (134), Expect = 2e-07
Identities = 97/438 (22%), Positives = 156/438 (35%), Gaps = 70/438 (15%)
Query: 93 LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP----AVLE 147
LQI + ED G Y C V L + + H+ V PP + P V E
Sbjct: 2597 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLGEVGVKE 2648
Query: 148 VQEL--EPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204
V+ +TL C + P P + W G+ + QV + L+I+ + SG Y
Sbjct: 2649 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 2708
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244
C A++ G +L+ PP+ S + +
Sbjct: 2709 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 2768
Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303
L C A P +W++++ + V +L G L++ + ++AG Y+C
Sbjct: 2769 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 2823
Query: 304 SNG-----------LLHPP-------SASAYLTVLCMPGV-IRCPVRANPPLLFVSWTKD 344
SN +L PP +TV V ++CP N P+ +SW ++
Sbjct: 2824 SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTISWLQN 2882
Query: 345 GKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
G L P +G ++ ++ Y C N G+A RV + PP
Sbjct: 2883 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPR 2938
Query: 404 FIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPL 460
E+ + + +PC P P V+W K + L +V +L L
Sbjct: 2939 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 2998
Query: 461 TKEAHGHWECSASNAVAR 478
G + C A NA R
Sbjct: 2999 RLSDSGMYTCEALNAAGR 3016
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 125 bits (313), Expect = 3e-28
Identities = 133/492 (27%), Positives = 191/492 (38%), Gaps = 63/492 (12%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLP--IFIQFGLYSPRIDPDYVGRVR 86
VVG A +VL C + P I W R G +L QF
Sbjct: 2309 VVGLAPGQLVLECSV----EAEPAPKITWHRDGIVLQEDAHTQFP--------------- 2349
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV--HLTVNSPPQFQETPPA 144
++G LQ++ L D G Y C + A + V + +++ P + PPA
Sbjct: 2350 -ERGRFLQLQALSTADSGDYSCTA---------RNAAGSTSVAFRVEIHTVPTIRSGPPA 2399
Query: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSGV 203
V V + L C A G P P V+W+ L + ++ G+LRI+ V +G
Sbjct: 2400 V-NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2458
Query: 204 YTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
Y C AS++ GS L VL PP I P N T+ A L C A P L W
Sbjct: 2459 YLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 2518
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGL----------LHPPSA 313
F + Q R+L +L L A P D+ + CV SN + +H P
Sbjct: 2519 GQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2576
Query: 314 SA-----YLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368
A + + P V+ C P VSW+K G L + G+ G+L I
Sbjct: 2577 IADDQTDFTVTMMAPVVLTCH-STGIPAPTVSWSKAGAQLGA-RGSGYRVSPSGALEIGQ 2634
Query: 369 GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG-RELLIPCSAQ 427
G Y+C+ NS G A V L + + +P + V E+L+PC A
Sbjct: 2635 ALPIHAGRYTCSARNSAGVAH----KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2690
Query: 428 GDPPPVVSWTKVGRGLQG--QAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485
G P P ++W K G + QV L + + E G++ C A N+ T +
Sbjct: 2691 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2750
Query: 486 YVLGTSPHVVTN 497
V P V+ N
Sbjct: 2751 VV--QVPPVIEN 2760
Score = 118 bits (295), Expect = 4e-26
Identities = 110/386 (28%), Positives = 162/386 (41%), Gaps = 37/386 (9%)
Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
V LTV + P + P V V E E V L C A G P P +TW+ G ++ G +
Sbjct: 2658 VFLTVQASPVVKPLPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 2716
Query: 188 NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
G LRI +G Y C A ++ GSA T+L+V PPVI + + L
Sbjct: 2717 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 2776
Query: 248 CHAEAYP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG 306
C A P N+T W +D V S + + I G L + + DAG YTC N
Sbjct: 2777 CKARGSPEPNIT--WDKDGQPV---SGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENA 2831
Query: 307 LLHPPSASAYLTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQL 350
+ +LT+L +P +RC R +P + WT + + +
Sbjct: 2832 -VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPR-IGWTVNDRPVT- 2888
Query: 351 DKFPGWSQGTEGSLI--IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408
G S+ GS + A+ ED+ G Y C N +G V+ V +K P
Sbjct: 2889 ---EGVSEQDGGSTLQRAAVSREDS-GTYVCWAENRVGRT--QAVSFVHVKEAPVLQGEA 2942
Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ--AQVDSNSSLILRPLTKEAHG 466
+ VG + + C +GDP P + W K G L+G N SL +R ++ G
Sbjct: 2943 FSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAG 3002
Query: 467 HWECSASNAVARVATSTNVYVLGTSP 492
++C A N + VA + VL ++P
Sbjct: 3003 RYQCLAENEMG-VAKKVVILVLQSAP 3027
Score = 108 bits (271), Expect = 2e-23
Identities = 137/493 (27%), Positives = 192/493 (38%), Gaps = 53/493 (10%)
Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
+V G AG+S+ L CD A P+ I WL+ L+ + + + Y + VG RL
Sbjct: 27 NVSGMAGQSLTLECD----ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 82
Query: 88 -QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL 146
+G SL ++ D G Y CR + DF HL V +PP A
Sbjct: 83 LDEGQSLHFPRIQEGDSGLYSCRAEN-QAGTAQRDF------HLLVLTPPSVLGAG-AAQ 134
Query: 147 EVQELE--PVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG--TLRIRRVERGSSG 202
EV L V L+C G P P V W + + G +QVQ LRI G G
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 194
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQD--VSLACHAEAYPA-NLTY 259
Y C A S G QL V PP I + V +D V L C A P N+T
Sbjct: 195 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT- 253
Query: 260 SWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNG-----------LL 308
WF+D + +++ V L+L Q DAG YTC SN +
Sbjct: 254 -WFKDGALLPTSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 309
Query: 309 HPPSAS-------AYLTVLCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGT 360
PP+ V P + C R +P P L SW +G L + + T
Sbjct: 310 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEG--LPVAESNESRLET 365
Query: 361 EGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
+GS++ + E + G YSC + G A V + P + + VG+
Sbjct: 366 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV-PPQLLVAEGLGQVTTIVGQP 424
Query: 420 LLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 476
L +PC A G P P + W + GR L G ++L + + + G + C A+N
Sbjct: 425 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 484
Query: 477 ARVATSTNVYVLG 489
V V G
Sbjct: 485 GTAGAEVEVSVHG 497
Score = 108 bits (271), Expect = 2e-23
Identities = 121/487 (24%), Positives = 190/487 (39%), Gaps = 64/487 (13%)
Query: 24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83
P VV V A E V+L C+ A P I W + G + +
Sbjct: 2672 PSVVRAV--AEEEVLLPCE----ASGIPRPTITWQKEGLNVATGVS-------------- 2711
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETP 142
++ G L+I ED G Y C I ++ + L V PP +
Sbjct: 2712 -TQVLPGGQLRIAHASPEDAGNYLC--------IAKNSAGSAMGKTRLVVQVPPVIENGL 2762
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSS 201
P L E L C ARGSP P++TW G+ + +G+ +Q +G L ++ +E +
Sbjct: 2763 PD-LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 2821
Query: 202 GVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSW 261
G YTC A + G A L +L PV P + ++ + L C A P
Sbjct: 2822 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2881
Query: 262 FQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSAS------- 314
D +S +L+ A +D+G Y C N + + S
Sbjct: 2882 VNDRPVTEGVSEQDG------GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 2935
Query: 315 --------AYLTVLCMPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSL 364
+YL V + G I+ C VR +P + + W KDG L+ Q GSL
Sbjct: 2936 PVLQGEAFSYL-VEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPLRGSHLRHQLQN--GSL 2991
Query: 365 IIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424
I D G Y C N +G A V ++L++ P F P++ + G ++ + C
Sbjct: 2992 TIRRTERDDAGRYQCLAENEMGVA--KKVVILVLQSAPVFQVEPQDMTVRS-GDDVALRC 3048
Query: 425 SAQGDPPPVVSWTKVGRGLQGQAQVDS--NSSLILRPLTKEAHGHWECSASNAVARVATS 482
A G+P P + W + G+ L+ ++ + + SL L + G ++C A N +
Sbjct: 3049 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATAR 3108
Query: 483 TNVYVLG 489
+ V G
Sbjct: 3109 AFLVVRG 3115
Score = 108 bits (269), Expect = 4e-23
Identities = 119/448 (26%), Positives = 180/448 (40%), Gaps = 63/448 (14%)
Query: 87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ------- 139
L +G LQI+ +V D G Y C + +D ++ + PP FQ
Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD-------FNVLIQVPPMFQKVGDFSA 1459
Query: 140 ---------ETPPAVLEVQEL---EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
E V E +E+ P L C P P +TW + L G +Q
Sbjct: 1460 AFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ 1519
Query: 188 NG-TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPP----KNSTVNASQ 242
G L+I V ++G Y+C+AS+ G +LLVL PPVI+ + TVNAS
Sbjct: 1520 GGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS 1579
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTC 301
VSL C A P T SW Q+ + PR+++L DG L++ + DA Y C
Sbjct: 1580 TVSLQCPALGNPVP-TISWLQNGLPF----SPSPRLQVLEDGQVLQVSTAEVADAASYMC 1634
Query: 302 VPSN-----------GLLHPPSASA----YLTVLCMPGV-IRCPVRANPPLLFVSWTKDG 345
V N + PP + +T + V + C V A+P V+W KD
Sbjct: 1635 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPN-PEVTWYKDS 1693
Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
+AL L + GT +L + G Y+C N+ G + ++ + PPAF
Sbjct: 1694 QALSLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGR--DQKLVQLSVLVPPAFR 1750
Query: 406 ERPK---EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRP 459
+ P+ + VG + ++ C P P V+W K G+ L Q + L ++
Sbjct: 1751 QAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQE 1810
Query: 460 LTKEAHGHWECSASNAVARVATSTNVYV 487
G + C SN + + V
Sbjct: 1811 AQVSDKGLYSCKVSNVAGEAVRTFTLTV 1838
Score = 106 bits (264), Expect = 1e-22
Identities = 145/506 (28%), Positives = 211/506 (41%), Gaps = 81/506 (16%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGAS 92
G+ V L C+ G+PP V WL+ G SP + D +R G S
Sbjct: 1950 GQEVRLDCEA---DGQPPPDVA-WLKDG------------SP-LGQDMGPHLRFYLDGGS 1992
Query: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPA--VLEVQE 150
L ++GLR D G Y C H P + A V++ V PP ++ L +
Sbjct: 1993 LVLKGLRASDAGAYTCVA-----HNPAGEDARLHTVNVLV--PPTIKQGADGSGTLVSRP 2045
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TLRIRRVERGSSGVYTCQAS 209
E VT+ C RGSP HV+W G L Q + +G TLRI +V+ +G++TC A+
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2105
Query: 210 STEGSATHATQLLVLGPPVI--VVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
S G A L V PPV+ V + V V L C A P L SW +D
Sbjct: 2106 SPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLV-SWMKDGEP 2164
Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPP--SAS 314
+ S Q SL+L A D+G Y+CV + ++ PP S
Sbjct: 2165 LLSQSLEQ-------GPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2217
Query: 315 AYLTVLCM----PGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGN 370
T L + P + C + P ++W KDG+A L + S+ T L
Sbjct: 2218 GQPTELSLTPGAPMELLCDAQGTPQ-PNITWHKDGQA--LTRLENNSRATR-----VLRV 2269
Query: 371 EDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVG---RELLIPCSAQ 427
DA G Y+C + G S RV ++APP + P+ F VG +L++ CS +
Sbjct: 2270 RDA-GLYTCLAESPAGAIEKS--FRVRVQAPPNIV-GPRGPRF-VVGLAPGQLVLECSVE 2324
Query: 428 GDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVARVATSTN 484
+P P ++W + G LQ A + L L+ L+ G + C+A NA + +
Sbjct: 2325 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384
Query: 485 VYVLGTSPHVVTNVSVVALPKGANVS 510
V + H V + + P NVS
Sbjct: 2385 VEI-----HTVPTIR--SGPPAVNVS 2403
Score = 103 bits (257), Expect = 1e-21
Identities = 137/498 (27%), Positives = 188/498 (37%), Gaps = 76/498 (15%)
Query: 26 VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRV 85
V V A +V L C PA P+ I WL+ G LP SPR+
Sbjct: 1570 VEEVTVNASSTVSLQC----PALGNPVPTISWLQNG--LPFSP-----SPRLQV------ 1612
Query: 86 RLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQ----E 140
L+ G LQ+ V D Y C + E+ + + L V PP+ E
Sbjct: 1613 -LEDGQVLQVSTAEVADAASYMC--------VAENQAGSAEKLFTLRVQVPPRIAGLDLE 1663
Query: 141 TPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT--LRIRRVER 198
A+L V+L C P P VTW + L G+ +V + GT L++ R
Sbjct: 1664 QVTAILN----SSVSLPCDVHAHPNPEVTWYKDSQALSLGE-EVFLLPGTHTLQLGRARL 1718
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNS----TVNASQDVSLACHAEAYP 254
SG+YTC+A + G QL VL PP P+ V L+C +A P
Sbjct: 1719 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1778
Query: 255 ANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN-------- 305
T +W++D + L R + L G L + Q D G Y+C SN
Sbjct: 1779 -EPTVTWYKDGQPLV----LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRT 1833
Query: 306 --------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-W 356
P V P V+ C V + P V+W KD ++ G
Sbjct: 1834 FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAPTVTWLKDRMPVESSAVHGVV 1892
Query: 357 SQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 416
S+G G L ++ G Y+C N+ A V VL+ AP E+
Sbjct: 1893 SRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLV-APRIRSSGVAREHHVLE 1949
Query: 417 GRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD------SNSSLILRPLTKEAHGHWEC 470
G+E+ + C A G PPP V+W K G L GQ SL+L+ L G + C
Sbjct: 1950 GQEVRLDCEADGQPPPDVAWLKDGSPL-GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2008
Query: 471 SASNAVARVATSTNVYVL 488
A N A V VL
Sbjct: 2009 VAHNPAGEDARLHTVNVL 2026
Score = 102 bits (254), Expect = 2e-21
Identities = 120/434 (27%), Positives = 174/434 (40%), Gaps = 59/434 (13%)
Query: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQE 150
A LQ++ V D G Y C H E + WV P F L V+E
Sbjct: 842 ALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNVWV------APVFPLRESHTLTVRE 894
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDL-GQGQG--QVQVQNGTLRIRRVERGSSGVYTCQ 207
P L C RG P P ++W+ G+ L G+G G V L + + + G YTC+
Sbjct: 895 GHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 954
Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNST-VNASQD--VSLACHAEAYPANLTYSWFQD 264
S+ G+++ QL V PP I P + T V+ QD +L C+A P T +W +D
Sbjct: 955 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP-TVTWERD 1013
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPSA 313
V LQ + + SL + Q G Y+CV N +L PP
Sbjct: 1014 GQPVGAELGLQLQNQ---GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1070
Query: 314 SAYL-------TVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII 366
L L P + C PP + W + + + PG E + ++
Sbjct: 1071 IGDLDPLTNITAALHSPLTLLCEAMGIPPPA-IRWFRGEEPVS----PG-----EDTYLL 1120
Query: 367 ALG--------NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV-G 417
A G E G YSC N G A + VL+ PP+ EE + + G
Sbjct: 1121 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDG 1178
Query: 418 RELLIPCSAQGDPPPVVSWTKVGRGL-QGQAQVDSNSSLILRPL--TKEAHGHWECSASN 474
+ + C+ G P P ++W K GR L +G A S ++L+ L + GH+ C A+N
Sbjct: 1179 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1238
Query: 475 AVARVATSTNVYVL 488
AV + VL
Sbjct: 1239 AVGEKTKHFQLSVL 1252
Score = 102 bits (253), Expect = 3e-21
Identities = 113/430 (26%), Positives = 172/430 (40%), Gaps = 47/430 (10%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ--ETPPAVLE 147
G L + ++ +G Y C + + +D + L V+ PPQ PP +
Sbjct: 935 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQD-------LQLEVHVPPQIAGPREPPTQVS 987
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTC 206
V + TL C A G P P VTW+ G+ +G G Q+Q Q +L + R + +G Y+C
Sbjct: 988 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1047
Query: 207 QASSTEGSATHATQLLVLGPPVIV---VPPKNSTVNASQDVSLACHAEAYPANLTYSWFQ 263
A + G A +L VL PP ++ P N T ++L C A P WF+
Sbjct: 1048 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP-AIRWFR 1106
Query: 264 DNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN-----------GLLHPPS 312
V S + + L++ TQ D+G Y+C+ SN +L PPS
Sbjct: 1107 GEEPV---SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPS 1163
Query: 313 -----ASAYLTVL-CMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
+ VL + C V +P P L +W KDG+ L + +G L+
Sbjct: 1164 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFKDGRPLA--RGDAHHISPDGVLL 1219
Query: 366 IAL-GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAF---IERPKEEYFQEVGRELL 421
L N + G YSC N++G VLL AP + EE V +
Sbjct: 1220 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLL-APTILGGAEDSADEEVTVTVNNPIS 1278
Query: 422 IPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNAVAR 478
+ C A P P ++W K G + + L + KE G + C +N +
Sbjct: 1279 LICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE 1338
Query: 479 VATSTNVYVL 488
+ +V VL
Sbjct: 1339 AVKNYHVEVL 1348
Score = 100 bits (249), Expect = 8e-21
Identities = 142/551 (25%), Positives = 216/551 (39%), Gaps = 63/551 (11%)
Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETPPAVL 146
+ G L+I G V D+G Y+C V F DF L V++PP + +
Sbjct: 178 EDGQVLRITGSHVGDEGRYQC-VAFSPAGQQARDF------QLRVHAPPTIWGSNETGEV 230
Query: 147 EVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGT-LRIRRVERGSSGVYT 205
V E V L C ARG P P++TW G L V + G L++ R + +GVYT
Sbjct: 231 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 290
Query: 206 CQASSTEGSATHATQLLVLGPPVIVVP---PKNSTVNASQDVSLACHAEAYPANLTYSWF 262
C+AS+ G+A AT+L V PP I P A + V+L C A +P+ T SW
Sbjct: 291 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP-TLSWH 349
Query: 263 QDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSN---------------- 305
+ + V + R+ DGS LRL + +G Y+CV S+
Sbjct: 350 HEGLPVAESN----ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVP 405
Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGK-ALQLDKFPGWSQGTEGS 363
LL T++ P + C + P+ + W ++G+ A +L SQGT +
Sbjct: 406 PQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQWLQNGRPAEELAGVQVASQGT--T 462
Query: 364 LIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIP 423
L I D G ++C N GTAG V + P +E P +Y P
Sbjct: 463 LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFP 522
Query: 424 CS----------AQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEA-----HGHW 468
+ A PP V W G L G+ + + PL E G +
Sbjct: 523 AACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 581
Query: 469 ECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYT 528
C+A+N + VL P++ A+ + A+V+ E G S W+
Sbjct: 582 TCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVS-WF- 638
Query: 529 PLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAP 587
+ + W+ + V V L + Q + +A N GS + ++ P
Sbjct: 639 ----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP 694
Query: 588 EGLPTTPAAPG 598
+ P+ PG
Sbjct: 695 PRITLPPSLPG 705
Score = 94.7 bits (234), Expect = 4e-19
Identities = 128/513 (24%), Positives = 195/513 (38%), Gaps = 83/513 (16%)
Query: 16 QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75
Q A R P VSVV L C+ G+PP + W R G P+ + GL
Sbjct: 975 QIAGPREPPTQVSVVQDG--VATLECNA---TGKPP-PTVTWERDG--QPVGAELGL--- 1023
Query: 76 RIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNS 134
+LQ +G SL +E + G Y C L L+V
Sbjct: 1024 ----------QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK-------FELSVLV 1066
Query: 135 PPQF--QETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG-TL 191
PP+ P + P+TL C A G P P + W + + G+ + G L
Sbjct: 1067 PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWML 1126
Query: 192 RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNA--SQDVSLACH 249
++ + + SG+Y+C AS+ G A + VL PP I + Q L C+
Sbjct: 1127 KMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1186
Query: 250 AEAYPANLTYSWFQDNI-----NVFHISRLQPRVRILVDGSL-RLLATQPDDAGCYTCVP 303
+P +WF+D + HIS DG L ++L AG Y+C+
Sbjct: 1187 VTGHPQP-KLTWFKDGRPLARGDAHHISP---------DGVLLQVLQANLSSAGHYSCIA 1236
Query: 304 SNGLLHPPSASAYLTVLCMPGVI---------RCPVRANPPLLFV-----------SWTK 343
+N + + L+VL P ++ V N P+ + +W K
Sbjct: 1237 ANAV-GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1295
Query: 344 DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
DG + + GT G I+ EDA G+Y+C N LG A + VL+ PP+
Sbjct: 1296 DGAPFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLI--PPS 1352
Query: 404 F------IERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSL 455
E +E +V L + C + PPP + W K G+ + + QV L
Sbjct: 1353 ISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL 1412
Query: 456 I-LRPLTKEAHGHWECSASNAVARVATSTNVYV 487
+ ++P G + C A+N NV +
Sbjct: 1413 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1445
Score = 94.0 bits (232), Expect = 8e-19
Identities = 115/432 (26%), Positives = 163/432 (37%), Gaps = 55/432 (12%)
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH--LTVNSPPQFQETPPAVLE 147
G L+IE ++ D G Y C + A + + L VN PP+ P
Sbjct: 656 GRVLRIEQAQLSDAGSYRCVA---------SNVAGSTELRYGLRVNVPPRITLPPSLPGP 706
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLG-QGQGQVQVQNG--TLRIRRVERGSSGVY 204
V PV L C A G+P P + W G + G +QV G L + SG Y
Sbjct: 707 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 766
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
+C A S G L V PP I+ N +V A++ V+L C + A P + SW++D
Sbjct: 767 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWKD 825
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPD---DAGCYTCVPSNGLLH------------ 309
L+PR + + LL DAG YTC N H
Sbjct: 826 G------RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA 879
Query: 310 ---PPSASAYLTVL-CMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG--- 362
P S LTV P + C R P +SW KDG+ L PG G +
Sbjct: 880 PVFPLRESHTLTVREGHPTRLSCECR-GVPFPKISWRKDGQPL-----PGEGAGLQHVSA 933
Query: 363 -SLIIALGNEDAL--GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
++ LG G Y+C N +G + V + A P +
Sbjct: 934 VGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV 993
Query: 420 LLIPCSAQGDPPPVVSWTKVGR--GLQGQAQVDSNSSLILRPLTKEAH-GHWECSASNAV 476
+ C+A G PPP V+W + G+ G + Q+ + + + AH G + C A N
Sbjct: 994 ATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLA 1053
Query: 477 ARVATSTNVYVL 488
R + VL
Sbjct: 1054 GRAERKFELSVL 1065
Score = 93.6 bits (231), Expect = 1e-18
Identities = 130/517 (25%), Positives = 200/517 (38%), Gaps = 77/517 (14%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPP--AGRPPLHVIEWLRFGFLLPIFIQF 70
V+ + + P+++ G + ++G L P A P+ I+WL+ G
Sbjct: 395 VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------- 445
Query: 71 GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130
R + G +G +L I+ + ++ G + C+ + G+ V +
Sbjct: 446 -----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-------TNEAGTAGAEVEV 493
Query: 131 TVNSPPQFQETPPAVLEV---------QELEPVTLRC---VARG---SPLPHVT--WKLR 173
+V+ E P VLEV + C V RG P P + W
Sbjct: 494 SVHG-----EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 548
Query: 174 GKDLGQGQGQVQVQN--GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVV 231
G G+ G + L+I +V+ G+YTC A++ G + L VL PP I
Sbjct: 549 GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP 608
Query: 232 PPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLA 290
P N V + V+L C A P SWF+ + V V + VDG LR+
Sbjct: 609 GPVNKAVLENASVTLECLASGVPPP-DVSWFKGHQPV----SSWMGVTVSVDGRVLRIEQ 663
Query: 291 TQPDDAGCYTCVPSN---------GL-LHPPSASAYLTVLCMPGVIRCPVR-----ANPP 335
Q DAG Y CV SN GL ++ P L P ++ PVR P
Sbjct: 664 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAP 723
Query: 336 LLFVSWTKDGKALQLDKFPGWSQGTEGS-LIIALGNEDALGEYSCTPYNSLGTAGPSPVT 394
+ W KDG + PG G L +A G YSC +++G V
Sbjct: 724 SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 783
Query: 395 RVLLKAPPAFIERPKEEYFQEVGRE-LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNS 453
+V + PP+ + +E V E + + C + PPPV+SW K GR L+ + V ++
Sbjct: 784 QVHM--PPSIL--GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 839
Query: 454 SLILRPLTKE---AHGHWECSASNAVARVATSTNVYV 487
L + + GH+ C A N N+ V
Sbjct: 840 DKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 876
Score = 63.9 bits (154), Expect = 8e-10
Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 11/145 (7%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTV-NSPPQFQETP 142
R +LQ G SL I +D G Y+C + E++ V + V S P FQ
Sbjct: 2983 RHQLQNG-SLTIRRTERDDAGRYQC--------LAENEMGVAKKVVILVLQSAPVFQ-VE 3032
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
P + V+ + V LRC A G P P + W G+ L + + +G+L + VE G +G
Sbjct: 3033 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAG 3092
Query: 203 VYTCQASSTEGSATHATQLLVLGPP 227
Y C A + GSAT L+V G P
Sbjct: 3093 TYDCVAHNLLGSATARAFLVVRGEP 3117
Score = 57.8 bits (138), Expect = 6e-08
Identities = 97/438 (22%), Positives = 159/438 (36%), Gaps = 70/438 (15%)
Query: 93 LQIEGLRVEDQGWYECRVFF-LDQHIPEDDFANGSWVHLTVNSPPQFQETPP-AVLEVQE 150
LQI + ED G Y C V L + + H+ V PP + P A + V+E
Sbjct: 1315 LQILNAQKEDAGQYTCVVTNELGEAVKN--------YHVEVLIPPSISKDDPLAEVGVKE 1366
Query: 151 LEP-----VTLRCVARGSPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVY 204
++ +TL C + P P + W G+ + QV + L+I+ + SG Y
Sbjct: 1367 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRY 1426
Query: 205 TCQASSTEGSATHATQLLVLGPPVIVVPPKNST--------------------VNASQDV 244
C A++ G +L+ PP+ S + +
Sbjct: 1427 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1486
Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVP 303
L C A P +W++++ + V +L G L++ + ++AG Y+C
Sbjct: 1487 YLYCDTNAIPPP-DLTWYREDQPL----SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA 1541
Query: 304 SNG-----------LLHPP-------SASAYLTVLCMPGV-IRCPVRANPPLLFVSWTKD 344
SN +L PP +TV V ++CP N P+ +SW ++
Sbjct: 1542 SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN-PVPTISWLQN 1600
Query: 345 GKALQLDKFPGWSQGTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA 403
G L P +G ++ ++ Y C N G+A RV + PP
Sbjct: 1601 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPR 1656
Query: 404 FIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPL 460
E+ + + +PC P P V+W K + L +V +L L
Sbjct: 1657 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1716
Query: 461 TKEAHGHWECSASNAVAR 478
G + C A NA R
Sbjct: 1717 RLSDSGMYTCEALNAAGR 1734
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 124 bits (311), Expect = 5e-28
Identities = 141/499 (28%), Positives = 204/499 (40%), Gaps = 83/499 (16%)
Query: 29 VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
V+ GE VL C+ +G PP VI W R G + +
Sbjct: 590 VLVAVGEEAVLVCEA---SGVPPPRVI-WYRGGLEM--------------------ILAP 625
Query: 89 KGAS---LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAV 145
+G+S L+I + D G Y CR + E A+ + L V PQ E P V
Sbjct: 626 EGSSSGKLRIPAAQERDAGTYTCRA------VNELGDASAE-IQLAVGHAPQLTELPRDV 678
Query: 146 LEVQELEPVTLRCVARGSPLPHVTWKLR-----GKDLGQGQGQV--QVQNGTLRIRRVER 198
V+ L C A G P P VTW+ G LG G+G Q +G L V
Sbjct: 679 T-VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 737
Query: 199 GSSGVYTCQASSTEGSATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPAN 256
Y C+A + G +L+V G PP I V Q VSL C A
Sbjct: 738 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 797
Query: 257 LTYSWFQDNINVFHISRLQPRVR--ILVDGSLRLLATQPDDAGCYTCVPSN--GLLHP-- 310
W +D L P R I DGSL L + AG Y+CV +N G H
Sbjct: 798 PERHWLKDG------RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV 851
Query: 311 -----------PSASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG 359
P+A+ ++T +P + C V + P ++WTK+ AL + P ++
Sbjct: 852 ELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTITWTKETNALT-SRGPHYNVS 909
Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE------EYF 413
EG+L+IA + G Y CT N++G + S R+ + P +
Sbjct: 910 KEGTLLIAQPSAQDAGAYVCTATNTVGFS--SQEMRLSVNTKPRIHMNGSRNANVPLQVT 967
Query: 414 QEVGRELLIPCSAQGDPPPVVSWTKVGR---GLQGQAQVDSNSSLILRPLTKEAHGHWEC 470
+ G E+ + C A+G PPP+V+WTK R + + + + SL L + GH+EC
Sbjct: 968 AKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYEC 1027
Query: 471 SASNAVARVATSTNVYVLG 489
+ASN ++++ YVLG
Sbjct: 1028 TASNP---AGSASHRYVLG 1043
Score = 97.1 bits (240), Expect = 9e-20
Identities = 105/367 (28%), Positives = 151/367 (41%), Gaps = 44/367 (11%)
Query: 152 EPVTLRCVARGSPLPHVTWKLRGKD-LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASS 210
+P+ + C S LP RG+ LG+ + + N + I R + G Y C A S
Sbjct: 325 QPLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 383
Query: 211 TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACH--AEAYPANLTYSWFQDNINV 268
G+ Q++V PP +VP N TV+ + L+C EA P NLT W +D
Sbjct: 384 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA-PYNLT--WVRD---- 436
Query: 269 FHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPG 324
R+ P RV L D SL + P D G Y CV SN AS +L V P
Sbjct: 437 ---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA-NGVTRASVWLLVREAPQ 492
Query: 325 V----------------IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLII-A 367
V + C + P +SW+++ +ALQ D +G+LII
Sbjct: 493 VSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDS--RIHVDAQGTLIIQG 549
Query: 368 LGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQ 427
+ EDA G YSC N +GT T L P + VG E ++ C A
Sbjct: 550 VAPEDA-GNYSCQATNEVGT---DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 605
Query: 428 GDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYV 487
G PPP V W + G + + S+ L + + G + C A N + + + V
Sbjct: 606 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665
Query: 488 LGTSPHV 494
G +P +
Sbjct: 666 -GHAPQL 671
Score = 96.7 bits (239), Expect = 1e-19
Identities = 138/535 (25%), Positives = 194/535 (36%), Gaps = 86/535 (16%)
Query: 14 ISQGADGRGKPEVV------------SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFG 61
+S+ GR K ++V +V GE+ VL C +L G P + + W+R
Sbjct: 382 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL---GEAPYN-LTWVR-- 435
Query: 62 FLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDD 121
R+ P GRV SL+I G+ D G Y+C
Sbjct: 436 ------------DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA----------S 473
Query: 122 FANG---SWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG 178
ANG + V L V PQ + Q +E V + C A G P PH++W + L
Sbjct: 474 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQAL- 531
Query: 179 QGQGQVQVQ-NGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNST 237
Q ++ V GTL I+ V +G Y+CQA++ G+ L PP +
Sbjct: 532 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 591
Query: 238 VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAG 297
V ++ L C A P W++ + + L P G LR+ A Q DAG
Sbjct: 592 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMI----LAPEGS--SSGKLRIPAAQERDAG 644
Query: 298 CYTCVPSNGLLHPPSASAYLTV----------------LCMPGVIRCPVRANPPLLFVSW 341
YTC N L SA L V L ++ C PP V+W
Sbjct: 645 TYTCRAVNE-LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTW 702
Query: 342 TK-DGKALQLDKFPGWS----QGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396
+ DG+ L L G Q G L + Y C N G V
Sbjct: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
Query: 397 LLKAPPAFIERPKEEYFQEVGRELLIPCSA-QGDPPPVVSWTKVGRGLQ--GQAQVDSNS 453
APP E G+ + +PC G P P W K GR L + + ++
Sbjct: 763 TGHAPPQIASSAPTVRVLE-GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG 821
Query: 454 SLILRPLTKEAHGHWECSASNAVARVATSTNVYVL------GTSPHVVTNVSVVA 502
SL L +E G + C A+N + V T+ H +TN V A
Sbjct: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPA 876
Score = 53.5 bits (127), Expect = 1e-06
Identities = 36/105 (34%), Positives = 54/105 (51%), Gaps = 7/105 (6%)
Query: 128 VHLTVNSPPQFQ------ETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQ 181
+ L+VN+ P+ P + + E VTL C A+GSP P VTW + +
Sbjct: 942 MRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT 1001
Query: 182 GQVQV-QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLG 225
+ + +G+LR+ +V+ G SG Y C AS+ GSA+H L V G
Sbjct: 1002 NRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQG 1046
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 122 bits (306), Expect = 2e-27
Identities = 268/1142 (23%), Positives = 402/1142 (35%), Gaps = 203/1142 (17%)
Query: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
+VV GE VL C +PP G P V W + G L + GR+ +
Sbjct: 174 NVVVAVGEPAVLEC--VPPRGHPEPSV-SWRKDGARLK--------------EEEGRITI 216
Query: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLE 147
+ G + L+ D G Y C + + + V P F P +
Sbjct: 217 RGGKLMMSHTLK-SDAGMYVCVASNMAGE------RESAAAEVMVLERPSFLRRPVNQVV 269
Query: 148 VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQ 207
+ + PVT C +G P P + W+ +L G+ +++ + +L I V G YTC
Sbjct: 270 LADA-PVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDH-SLWIGHVSAEDEGTYTCV 327
Query: 208 ASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
A ++ G A + L V PP +V P++ + V+ C + P + W ++
Sbjct: 328 AENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIF-WQKEGSQ 386
Query: 268 V--FHISRLQPRVRILVD--GSLRLLATQPDDAGCYTC--------VPSNGLLHPPSAS- 314
V F LQP R V G L + A Q DAG Y C + + LL AS
Sbjct: 387 VLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASL 446
Query: 315 -----------AYLTVLCMPGV-IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEG 362
A T++ V + C V NP V W KDG+ LQ D + G
Sbjct: 447 DGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPS-VRWKKDGQWLQGDDLQ-FKTMANG 504
Query: 363 SLIIALGNEDALGEYSCTPYNSLGTA------------GPSPVTRVLLKAPPAFIERPKE 410
+L IA E +G YSC +S G A G SP +PP P +
Sbjct: 505 TLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPG---APSQ 561
Query: 411 EYFQEVGRELLI----PCSAQG-----------DPPPVVSWTKVGRGLQGQAQVDSNSSL 455
E+ + + P G P +W V G+Q + S
Sbjct: 562 PVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSG--- 618
Query: 456 ILRPLT-----KEAHGHWECSASNAVARVATSTNVYVLGTSPH----------------- 493
L+P T A G W S + V S V +SP
Sbjct: 619 -LQPNTIYLFLVRAVGAWGLSEPSPV-----SEPVRTQDSSPSRPVEDPWRGQQGLAEVA 672
Query: 494 VVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHL 553
V +V P+ VSW +Q F V + P+ + L P + +
Sbjct: 673 VRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAG--PEGGSWTMLDLQSPSQQSTV 730
Query: 554 LVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPR 612
L GL P TQ Q V AQ + G G S + S PE P+ PP+
Sbjct: 731 L-RGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPS----------------GPPQ 773
Query: 613 GLVAVRTPRG---VLLHWDPPELVPKRLDGYVLEGR---QGSQGWEVLDPAVAGTETELL 666
G+ G + + W+PP +P + +G + E + G++ L+ + AG +
Sbjct: 774 GVAVALGGDGNSSITVSWEPP--LPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAM 831
Query: 667 VPGLIKDVLYEFRLVAFAGSFVSDPSNTANVS-------TSGLEVYPS-RTQLPGLLPQP 718
+ GL+ +LY + A + V PS V GLEV +L +L +P
Sbjct: 832 LRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREP 891
Query: 719 VLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALG 778
G C A+L+ + A RR++++ F+ T + P + G
Sbjct: 892 AFLAGSGAAC---GALLLGLCAALYW------RRKQRKELSHYTASFAYTPAVSFPHSEG 942
Query: 779 SGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFV 838
S + L +P L S W P+ +PS +P S P P PD R+
Sbjct: 943 LSGASSRPPMGLGPAPYSWLADS--WPHPSRSPSAQ-EPRGS--CCPSNP---DPDDRYY 994
Query: 839 MGPTVAAPQERSGREQAEPR--------TPAQRLARSFDCS-SSSPSG--------APQP 881
++ ++ R A P PA ++F PSG AP
Sbjct: 995 NEAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPE 1054
Query: 882 LCIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEE 930
D PV P P LP P P + LS E ++G P EE
Sbjct: 1055 WSQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCE-LSCLEGPEEELEGSSEP-EE 1112
Query: 931 PSPAAPPDYMDTRRCPTSSFLRSP---ETPPVSPRESLPGAVVGAGATAEPPYTALADWT 987
P P T + L +P ETP +P + +PP
Sbjct: 1113 WCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPH 1172
Query: 988 LRERLLPGLLPAAPRGSLTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPE 1047
L + +P +P P L+ G A A +LSP+P +++ ++
Sbjct: 1173 LHQ--MPRRVPLGPSSPLSVSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAPGR 1230
Query: 1048 RW 1049
W
Sbjct: 1231 TW 1232
Score = 118 bits (296), Expect = 3e-26
Identities = 153/596 (25%), Positives = 240/596 (40%), Gaps = 90/596 (15%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F+++P V+ V EP L CV RG P P V+W+ G L + +G++ ++ G L +
Sbjct: 168 FRQSPGNVV-VAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHT 226
Query: 197 ERGSSGVYTCQASSTEGS-ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G+Y C AS+ G + A +++VL P + P N V A V+ C + P
Sbjct: 227 LKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPP 286
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
W +++ + R I D SL + +D G YTCV N + AS
Sbjct: 287 P-RLRWRKEDGEL-----PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENS-VGRAEASG 339
Query: 316 YLTV-------------LCMPG---VIRCPVRANPPLLFVSWTKDGKALQLDKFPG---- 355
L+V + PG +C + NPP + W K+G + L FP
Sbjct: 340 SLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPA-IFWQKEGSQVLL--FPSQSLQ 396
Query: 356 ----WSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRV----LLKAPPAFIER 407
+S G L I G Y C + G+ + + L PP ++
Sbjct: 397 PTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQG 456
Query: 408 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQG---QAQVDSNSSLILRPLTKEA 464
P + +G + +PC G+P P V W K G+ LQG Q + +N +L + + +
Sbjct: 457 PANQTL-VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMD 515
Query: 465 HGHWECSASNAVARVATSTNVYV---LGTSPHVVTNVS----------VVALPKGA-NVS 510
G + C A ++ S + + G SP T S V + K + ++
Sbjct: 516 MGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLT 575
Query: 511 WEPGFDGGYLQRFSV--WYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 568
W+P G V ++P A + W ++A V V GLQP+T Y F V
Sbjct: 576 WKPNPQTGAAVTSYVIEAFSPAA------GNTWRTVADGVQLETHTVSGLQPNTIYLFLV 629
Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL--VAVRT------- 619
A G S + E + T ++P P + P +GL VAVR
Sbjct: 630 RAVGAWGLSEPSPV----SEPVRTQDSSPSRP---VEDPWRGQQGLAEVAVRLQEPIVLG 682
Query: 620 PRGVLLHW---DPPELVPKRLDGYVLEGRQGSQGWEVLD---PAVAGTETELLVPG 669
PR + + W P +LV + + G +G W +LD P+ T L PG
Sbjct: 683 PRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGG-SWTMLDLQSPSQQSTVLRGLPPG 737
Score = 117 bits (292), Expect = 8e-26
Identities = 156/621 (25%), Positives = 244/621 (39%), Gaps = 72/621 (11%)
Query: 118 PEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDL 177
P D NGS V ++ P+ E PP +L V EP TL C A G P P++ W G +
Sbjct: 47 PGDPSLNGSRVG-PEDAMPRIVEQPPDLL-VSRGEPATLPCRAEGRPRPNIEWYKNGARV 104
Query: 178 GQGQ-----GQVQVQNGTLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLG 225
+ ++ + +G L R+ G GVYTC A + G+A +A+ + +
Sbjct: 105 ATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVL 164
Query: 226 PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS 285
P N V + L C + SW +D + + R+ I G
Sbjct: 165 RDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGA---RLKEEEGRITIR-GGK 220
Query: 286 LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVR----ANPPLLF--- 338
L + T DAG Y CV SN SA+A + VL P +R PV A+ P+ F
Sbjct: 221 LMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCE 280
Query: 339 --------VSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGP 390
+ W K+ L ++ ++ SL I + + G Y+C NS+G A
Sbjct: 281 VKGDPPPRLRWRKEDGELPTGRY---EIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEA 337
Query: 391 SPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVG--------RG 442
S V PP + +P+++ G + C +G+PPP + W K G +
Sbjct: 338 SGSLSV--HVPPQLVTQPQDQ-MAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQS 394
Query: 443 LQ--GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTS-----PHVV 495
LQ G+ V L + + + G++ C A + + + + G S P ++
Sbjct: 395 LQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVIL 454
Query: 496 TNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLV 555
+ L G++V W P G Q W K + D + L +
Sbjct: 455 QGPANQTLVLGSSV-WLPCRVTGNPQPSVRW----KKDGQWLQGDDLQFKTMANGT-LYI 508
Query: 556 PGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTE-IPPPLSPPRGL 614
+Q +S +A++ G +S L E +P PPTE PP +P + +
Sbjct: 509 ANVQEMDMGFYSCVAKSSTGEATWSG-WLKMREDWGVSPD----PPTEPSSPPGAPSQPV 563
Query: 615 VAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQG--WE-VLDPAVAGTETELLVPGLI 671
V T + L W P + YV+E + G W V D T T V GL
Sbjct: 564 VTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHT---VSGLQ 620
Query: 672 KDVLYEFRLVAFAGSFVSDPS 692
+ +Y F + A +S+PS
Sbjct: 621 PNTIYLFLVRAVGAWGLSEPS 641
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 120 bits (300), Expect = 1e-26
Identities = 157/603 (26%), Positives = 239/603 (39%), Gaps = 102/603 (16%)
Query: 154 VTLRCVARGSPLP--HVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA--- 208
VTL CVA PL H+ WK G L G + N L I +G Y C+A
Sbjct: 233 VTLECVANARPLIKLHIIWKKDGVLLSGG---ISDHNRRLTIPNPTGSDAGYYECEAVLR 289
Query: 209 SSTEGSATHATQLLVLGPPVIVVPP-KNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267
SS+ S L VL PP V P ++ T + V + C A+ P + +W++D
Sbjct: 290 SSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPP-SITWYKDAA- 347
Query: 268 VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCM-PGVI 326
V + +L R R DG L++ PDD G + C N S YL V + P +
Sbjct: 348 VVEVEKLT-RFRQRNDGGLQISGLVPDDTGMFQCFARNAA-GEVQTSTYLAVTSIAPNIT 405
Query: 327 RCPV---------------RANPPLLFVSWTKDGKALQLD--KFPGWSQGTEGSLIIALG 369
R P+ + P ++W K + L + P ++ GSL+I+
Sbjct: 406 RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPT 465
Query: 370 NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGD 429
+ G Y+C NS G S V + I +P ++ G + + C D
Sbjct: 466 HISDAGTYTCLATNSRGVDEASADLVVWARTR---ITKPPQDQSVIKGTQASMVCGVTHD 522
Query: 430 PPPVVS--WTKVGRGLQGQA----QVDSNSSLILRPLTKEAHGHWECSASNAVARVATST 483
P + W K G L ++ ++D N SL + G + C +A + S
Sbjct: 523 PRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSA 582
Query: 484 NVYV--LGTSP-HVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD 540
++ V L +P H V +S V + N++W FDG +PL + M +
Sbjct: 583 HLRVRQLPHAPEHPVATLSTVER-RAINLTWTKPFDGN---------SPLIRYILEMSEN 632
Query: 541 ---WVSLAVPVG--AAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV--LSAPEGLPTT 593
W L V A + V GL P YQF + A N +G G FS+ +S PE
Sbjct: 633 NAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPE----- 687
Query: 594 PAAPGLPPTEIPPPLSPPRGLVAV-RTPRGVLLHWDPPELVPKR--LDGYVLEG-----R 645
PP +PP+ ++A RT + +++ W PP + L GY++
Sbjct: 688 -----------EPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLP 736
Query: 646 QGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVY 705
G Q + D V LL+ LI YE + A+ +++GL VY
Sbjct: 737 VGYQFKNITDADV----NNLLLEDLIIWTNYEIEVAAY--------------NSAGLGVY 778
Query: 706 PSR 708
S+
Sbjct: 779 SSK 781
Score = 89.0 bits (219), Expect = 2e-17
Identities = 129/541 (23%), Positives = 202/541 (37%), Gaps = 72/541 (13%)
Query: 102 DQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVAR 161
D G+YEC +P G++ L+V PPQF + P + + + V + C A+
Sbjct: 278 DAGYYECEAVLRSSSVPS--VVRGAY--LSVLEPPQFVKEPERHITAEMEKVVDIPCQAK 333
Query: 162 GSPLPHVTWKLRGKDLGQGQGQV-----QVQNGTLRIRRVERGSSGVYTCQASSTEGSAT 216
G P P +TW KD + + Q +G L+I + +G++ C A + G
Sbjct: 334 GVPPPSITWY---KDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQ 390
Query: 217 HATQLLVLG-PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQ 275
+T L V P I P +STV V LAC P +W + + S
Sbjct: 391 TSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP-RPAITWQKGERILASGSVQL 449
Query: 276 PRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIR-------- 327
PR L GSL + T DAG YTC+ +N ASA L V + +
Sbjct: 450 PRFTPLESGSLLISPTHISDAGTYTCLATNS-RGVDEASADLVVWARTRITKPPQDQSVI 508
Query: 328 --------CPVRANPPL-LFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYS 378
C V +P + + W KDG L + P GSL I+ +G Y+
Sbjct: 509 KGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYT 568
Query: 379 CTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSA--QGDPPPV--- 433
C ++ G S RV + P E P R + + + G+ P +
Sbjct: 569 CRVISAGGNDSRSAHLRV--RQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYI 626
Query: 434 -------VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR--VATSTN 484
WT + + +A +S+ ++ L + A N V + + T
Sbjct: 627 LEMSENNAPWTVLLASVDPKA-----TSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTE 681
Query: 485 VYVLGTSPHVVTNVSVVA---LPKGANVSWEP-------GFDGGYLQRFSVWYTPLAKRP 534
L P +V+A + + W+P G GY+ R+ + P+ +
Sbjct: 682 RVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQF 741
Query: 535 DRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLS-APEGLPTT 593
+ +LL+ L T Y+ V A N G G +S V +G+PT
Sbjct: 742 KNI--------TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTV 793
Query: 594 P 594
P
Sbjct: 794 P 794
Score = 85.1 bits (209), Expect = 4e-16
Identities = 131/559 (23%), Positives = 207/559 (37%), Gaps = 72/559 (12%)
Query: 164 PLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLV 223
P P VTW G+ + TL I +G Y QA + + +Q +
Sbjct: 141 PQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPIT 200
Query: 224 L------GP-----PVIVVPPKNSTVNA-SQDVSLACHAEAYP-ANLTYSWFQDNINVFH 270
L GP P I++PPKN++V A + +V+L C A A P L W +D + +
Sbjct: 201 LTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLL-- 258
Query: 271 ISRLQPRVRILVDGSLRLLATQP--DDAGCYTCVPSNGLLHPPSA--SAYLTVLCMPGVI 326
+ D + RL P DAG Y C PS AYL+VL P +
Sbjct: 259 -------SGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFV 311
Query: 327 R-----------------CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALG 369
+ C + PP ++W KD ++++K + Q +G L I+
Sbjct: 312 KEPERHITAEMEKVVDIPCQAKGVPP-PSITWYKDAAVVEVEKLTRFRQRNDGGLQISGL 370
Query: 370 NEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGD 429
D G + C N+ G S V AP I R + G +++ C G
Sbjct: 371 VPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPN--ITRGPLDSTVIDGMSVVLACETSGA 428
Query: 430 PPPVVSWTKVGRGL-QGQAQVD-----SNSSLILRPLTKEAHGHWECSASNAVARVATST 483
P P ++W K R L G Q+ + SL++ P G + C A+N+ S
Sbjct: 429 PRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 488
Query: 484 NVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVS 543
++ V+ + ++ KG S G V + P + + W
Sbjct: 489 DL-VVWARTRITKPPQDQSVIKGTQASMVCG----------VTHDPRV----TIRYIWEK 533
Query: 544 LAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTE 603
+G L + S +G+ ++ V+SA + L +
Sbjct: 534 DGATLGTESHPRIRLDRNGSLHISQTWSGDIGT--YTCRVISAG---GNDSRSAHLRVRQ 588
Query: 604 IPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTET 663
+P P ++ R + L W P L Y+LE + + W VL +V T
Sbjct: 589 LPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKAT 648
Query: 664 ELLVPGLIKDVLYEFRLVA 682
+ V GL+ Y+FRL A
Sbjct: 649 SVTVKGLVPARSYQFRLCA 667
Score = 80.1 bits (196), Expect = 1e-14
Identities = 75/277 (27%), Positives = 119/277 (42%), Gaps = 21/277 (7%)
Query: 77 IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136
++ + + R R + LQI GL +D G ++C F E + +L V S
Sbjct: 349 VEVEKLTRFRQRNDGGLQISGLVPDDTGMFQC---FARNAAGEVQTS----TYLAVTSIA 401
Query: 137 QFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQV----QVQNGTLR 192
P V + V L C G+P P +TW+ + L G Q+ +++G+L
Sbjct: 402 PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL 461
Query: 193 IRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEA 252
I +G YTC A+++ G + L+V I PP++ +V S+ C
Sbjct: 462 ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTH 521
Query: 253 YP-ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTC-VPSNGLLHP 310
P + Y W +D + + PR+R+ +GSL + T D G YTC V S G
Sbjct: 522 DPRVTIRYIWEKDGATLG--TESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG--GN 577
Query: 311 PSASAYLTVLCMPGVIRCPVRANPPL----LFVSWTK 343
S SA+L V +P PV + + ++WTK
Sbjct: 578 DSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTK 614
Score = 52.8 bits (125), Expect = 2e-06
Identities = 41/122 (33%), Positives = 52/122 (42%), Gaps = 16/122 (13%)
Query: 509 VSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSV 568
+SWEPG DG R+ YT + S +V A+ +V L+P T Y+F V
Sbjct: 1420 LSWEPGSDGLSPVRY---YTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRV 1476
Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628
A N +G FSE E L T AAP PT + V T VL+ W
Sbjct: 1477 KATNDIGDSEFSE----ESESLTTLQAAPDEAPTILS---------VTPHTTTSVLIRWQ 1523
Query: 629 PP 630
PP
Sbjct: 1524 PP 1525
Score = 42.7 bits (99), Expect = 0.002
Identities = 52/200 (26%), Positives = 76/200 (38%), Gaps = 41/200 (20%)
Query: 508 NVSWE-PGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAH-----LLVPGLQPH 561
NVSWE P F G L+ + + Y P + D VS V V L V L
Sbjct: 1741 NVSWEAPQFPNGILEGYRLVYEPCSPV------DGVSKIVTVDVKGNSPLWLKVKDLAEG 1794
Query: 562 TQYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620
Y+F + A+ V + P EG P P P + VR
Sbjct: 1795 VTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVP-----------------IIVRYS 1837
Query: 621 RGVLLHWDPPELVPKRLDGYVLEGRQGSQG-WEVL---DPAVAGTET---ELLVPGLIKD 673
+ +HW + + YV+E R +G W++L P + T ++L PG
Sbjct: 1838 SAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPG---- 1893
Query: 674 VLYEFRLVAFAGSFVSDPSN 693
V Y+FR++A PS+
Sbjct: 1894 VSYDFRVIAVNDYGFGTPSS 1913
Score = 37.7 bits (86), Expect = 0.064
Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 21/131 (16%)
Query: 557 GLQPHTQYQFSVLAQNKLGSGPFSE--IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL 614
GL+P + Y F + AQ + G G +E +V + P P+ P + ++
Sbjct: 1364 GLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDV---------- 1413
Query: 615 VAVRTPRGVLLHWDPPE--LVPKRLDGYVLEGRQGSQG-WEVLDPAVAGTETELLVPGLI 671
R VLL W+P L P R Y ++ R+ G W + +V+ + +V L
Sbjct: 1414 ----RARSVLLSWEPGSDGLSPVRY--YTIQTRELPSGRWALHSASVSHNASSFIVDRLK 1467
Query: 672 KDVLYEFRLVA 682
Y+FR+ A
Sbjct: 1468 PFTSYKFRVKA 1478
Score = 34.7 bits (78), Expect = 0.54
Identities = 37/142 (26%), Positives = 60/142 (42%), Gaps = 17/142 (11%)
Query: 555 VPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGL 614
+ L+ T+Y+ V A N +GSGP+S+ V+ T + P PT +
Sbjct: 1162 IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGR-----TRESVPSSGPTNVS--------- 1207
Query: 615 VAVRTPRGVLLHW-DPPELVPKRLD-GYVLEGRQGSQGWEVLDPAVAGTET-ELLVPGLI 671
T +L+ W + PE L GY + ++ + V G + + GL
Sbjct: 1208 ALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG 1267
Query: 672 KDVLYEFRLVAFAGSFVSDPSN 693
K VLYE +++AF PS+
Sbjct: 1268 KYVLYEVQVLAFTRIGDGSPSH 1289
Score = 34.3 bits (77), Expect = 0.71
Identities = 33/146 (22%), Positives = 57/146 (39%), Gaps = 20/146 (13%)
Query: 492 PHVVTNVSVVAL-PKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWV---SLAVP 547
P TN+ + + P+ + + PG+DG S W +W+ L+
Sbjct: 993 PGPPTNLGISNIGPRSVTLQFRPGYDGK--TSISRWLVEAQVGVVGEGEEWLLIHQLSNE 1050
Query: 548 VGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPP 607
A + VP L P T Y F + N +G+ P P+ P+ + + PP
Sbjct: 1051 PDARSMEVPDLNPFTCYSFRMRQVNIVGTSP------------PSQPSRK-IQTLQAPPD 1097
Query: 608 LSPPRGLVAVRTPRGVLLHWDP-PEL 632
++P + + + L W P PE+
Sbjct: 1098 MAPANVSLRTASETSLWLRWMPLPEM 1123
Score = 34.3 bits (77), Expect = 0.71
Identities = 47/159 (29%), Positives = 62/159 (38%), Gaps = 21/159 (13%)
Query: 558 LQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAV 617
L +T Y SV A N G GP S P T AAP P + L
Sbjct: 1690 LTGYTAYMVSVAAFNAAGDGP-----RSTPTQGQTQQAAPSAPSSVKFSEL--------- 1735
Query: 618 RTPRGVLLHWDPPELVPKRLDGY--VLEGRQGSQG-WEVLDPAVAG-TETELLVPGLIKD 673
T V + W+ P+ L+GY V E G +++ V G + L V L +
Sbjct: 1736 -TTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEG 1794
Query: 674 VLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLP 712
V Y FR+ A +F P ANV+T E P +P
Sbjct: 1795 VTYRFRI--RAKTFTYGPEIEANVTTGPGEGAPGPPGVP 1831
Score = 33.9 bits (76), Expect = 0.93
Identities = 46/184 (25%), Positives = 69/184 (37%), Gaps = 25/184 (13%)
Query: 503 LPKGANVSW-EPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPH 561
L VSW EPG G L + + + + R+ H +P V GL
Sbjct: 907 LDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTH-----YLPNVTLEYRVTGLTAL 961
Query: 562 TQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPR 621
T Y V A G G S +S+ G+P P PG PPT + ++ PR
Sbjct: 962 TTYTIEVAAMTSKGQGQVSASTISS--GVP--PELPG-PPTNLG---------ISNIGPR 1007
Query: 622 GVLLHWDPPELVPKRLDGYVLEGRQGSQG----WEVLDPAVAGTETELL-VPGLIKDVLY 676
V L + P + +++E + G G W ++ + + VP L Y
Sbjct: 1008 SVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCY 1067
Query: 677 EFRL 680
FR+
Sbjct: 1068 SFRM 1071
Score = 31.2 bits (69), Expect = 6.0
Identities = 49/181 (27%), Positives = 68/181 (37%), Gaps = 23/181 (12%)
Query: 325 VIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQ---GTEGSLIIALGNEDALGEYSCTP 381
VIR P A+ P V+W +DG+ K P S+ E +L+I G Y
Sbjct: 131 VIRAPRIASFPQPQVTWFRDGR-----KIPPSSRIAITLENTLVILSTVAPDAGRYYVQA 185
Query: 382 YNSLG----TAGPSPVTRVLLKAP-----PAFIERPKEEYFQEVGRELLIPCSAQGDP-- 430
N T+ P +T + P P I PK E+ + C A P
Sbjct: 186 VNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLI 245
Query: 431 PPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSA---SNAVARVATSTNVYV 487
+ W K G L G D N L + T G++EC A S++V V + V
Sbjct: 246 KLHIIWKKDGVLLSGGIS-DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 304
Query: 488 L 488
L
Sbjct: 305 L 305
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 120 bits (300), Expect = 1e-26
Identities = 179/714 (25%), Positives = 268/714 (37%), Gaps = 116/714 (16%)
Query: 25 EVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGR 84
E V + G SV+L C A P IEW + G L + + D R
Sbjct: 58 EPVDTLSVRGSSVILNCS----AYSEPSPKIEWKKDGTFLNL----------VSDD---R 100
Query: 85 VRLQKGASLQIEGL-----RVEDQGWYEC--RVFFLDQHIPEDDFANGSWVHLTVNSPPQ 137
+L SL I + D+G+Y+C V L I L V P+
Sbjct: 101 RQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRT-------AKLIVAGLPR 153
Query: 138 FQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVE 197
F P V L C +P V W+ + L +++ +G L I
Sbjct: 154 FTSQPEPS-SVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNAT 212
Query: 198 RGSSGVYTCQASST-EGSATHATQLLVLGPP------VIVVPPKNSTVNASQDVSLACHA 250
G G+Y C S + +L VL P V + P QDV L C A
Sbjct: 213 EGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVA 272
Query: 251 EAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310
P T W ++ + S R+ +L GSL + DDAG Y C+ NG
Sbjct: 273 SGLPTP-TIKWMKNEEALDTES--SERLVLLAGGSLEISDVTEDDAGTYFCIADNGN-ET 328
Query: 311 PSASAYLTVLCMPGVIRCPVR---------------ANPPLLFVSWTKDGK-ALQLDKFP 354
A A LTV P ++ P P V W K+G + D F
Sbjct: 329 IEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFK 388
Query: 355 GWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPA---FIERPKEE 411
+ L + +E G Y C N +G A +L AP P++
Sbjct: 389 IVKEHNLQVLGLVKSDE---GFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDV 445
Query: 412 YFQEVGRELL-----IPCS-AQGDPPPV-VSWTKVGRGLQ--------GQAQVDSNSSL- 455
V + P S GD V +TK G + G+ QV + +
Sbjct: 446 VASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMP 505
Query: 456 ----ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSW 511
I R + + HG E S+A RV T V + G +P++ + A P V+W
Sbjct: 506 ATVYIFRVMAQNKHGSGE---SSAPLRVETQPEVQLPGPAPNLR---AYAASPTSITVTW 559
Query: 512 EPGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLA 570
E G G +Q + ++Y + K D+ V V + + GL+ +T+Y F V+A
Sbjct: 560 ETPVSGNGEIQNYKLYY--MEKGTDKEQD------VDVSSHSYTINGLKKYTEYSFRVVA 611
Query: 571 QNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPP 630
NK G G +S P+ T + P+ P LS + VR + +++HW PP
Sbjct: 612 YNKHGPG------VSTPDVAVRTLSDV---PSAAPQNLS-----LEVRNSKSIMIHWQPP 657
Query: 631 ELVPK--RLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682
+ ++ GY + R+ S+ +V + V+GT+ L+ GL + Y FR+ A
Sbjct: 658 APATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAA 711
Score = 107 bits (267), Expect = 7e-23
Identities = 150/607 (24%), Positives = 225/607 (37%), Gaps = 84/607 (13%)
Query: 134 SPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGK--DLGQGQGQVQVQNGTL 191
+P F P L V+ V L C A P P + WK G +L + + +G+L
Sbjct: 51 TPFYFLVEPVDTLSVRG-SSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSL 109
Query: 192 RIRRV-----ERGSSGVYTCQAS--STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDV 244
I V + G Y C A+ S + +L+V G P P+ S+V A +
Sbjct: 110 FISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNA 169
Query: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPS 304
L C A W Q+ + L RV L G L + D G Y CV
Sbjct: 170 ILNCEVNADLVPFV-RWEQNRQPLL----LDDRVIKLPSGMLVISNATEGDGGLYRCVVE 224
Query: 305 NG------------LLHPPSASAYLTVLCMPG----------VIRCPVRANPPLLFVSWT 342
+G +L P + L L P V+ C V + P + W
Sbjct: 225 SGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPC-VASGLPTPTIKWM 283
Query: 343 KDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPP 402
K+ +AL + GSL I+ ED G Y C N G + ++A P
Sbjct: 284 KNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADN--GNETIEAQAELTVQAQP 341
Query: 403 AFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPL 460
F+++P Y E +++ C G P P V W K G + ++ +L + L
Sbjct: 342 EFLKQPTNIYAHE-SMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGL 400
Query: 461 TKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN--------VSVVALPKGANVSWE 512
K G ++C A N V + +L +P V+ + + ++W
Sbjct: 401 VKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWR 460
Query: 513 -PGFDG-GYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLA 570
P D G +SV+YT +R+ + G + + L P T Y F V+A
Sbjct: 461 TPASDPHGDNLTYSVFYTKEGIARERVEN-----TSHPGEMQVTIQNLMPATVYIFRVMA 515
Query: 571 QNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPP 630
QNK GSG SAP + T P ++P P R A +P + + W+ P
Sbjct: 516 QNKHGSGE-----SSAPLRVETQ------PEVQLPGPAPNLRAYAA--SPTSITVTWETP 562
Query: 631 ELVPKRLDGYVL----EGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAF--A 684
+ Y L +G Q +V + + GL K Y FR+VA+
Sbjct: 563 VSGNGEIQNYKLYYMEKGTDKEQDVDV-------SSHSYTINGLKKYTEYSFRVVAYNKH 615
Query: 685 GSFVSDP 691
G VS P
Sbjct: 616 GPGVSTP 622
Score = 57.0 bits (136), Expect = 1e-07
Identities = 125/563 (22%), Positives = 218/563 (38%), Gaps = 105/563 (18%)
Query: 208 ASSTEGSATHA--TQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDN 265
A++ GSA + + P +V P ++ V L C A + P+ W +D
Sbjct: 32 AAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSP-KIEWKKDG 90
Query: 266 INVFHISRLQPRVRILVDGSLRLLAT------QPDDAGCYTCVPS-NGLLHPPSASAYLT 318
+ +S R ++L DGSL + +PD+ G Y CV + L S +A L
Sbjct: 91 TFLNLVS--DDRRQLLPDGSLFISNVVHSKHNKPDE-GYYQCVATVESLGTIISRTAKLI 147
Query: 319 VLCMP----------------GVIRCPVRANPPLLFVSWTKDGKALQLD----KFPGWSQ 358
V +P ++ C V A+ + FV W ++ + L LD K P
Sbjct: 148 VAGLPRFTSQPEPSSVYAGNNAILNCEVNADL-VPFVRWEQNRQPLLLDDRVIKLPS--- 203
Query: 359 GTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVT-RVLLKAPP--------AFIERPK 409
G L+I+ E G Y C + + GP + V LK P F+++P
Sbjct: 204 ---GMLVISNATEGDGGLYRCV----VESGGPPKYSDEVELKVLPDPEVISDLVFLKQPS 256
Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQ----VDSNSSLILRPLTKEAH 465
+ +G+++++PC A G P P + W K L ++ + + SL + +T++
Sbjct: 257 P-LVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDA 315
Query: 466 GHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSV 525
G + C A N + + V P + + + + ++ +E G
Sbjct: 316 GTYFCIADNGNETIEAQAELTV-QAQPEFLKQPTNIYAHESMDIVFECEVTGK------- 367
Query: 526 WYTPLAKRPDRMHHDWV---SLAVP------VGAAHLLVPGLQPHTQYQFSVLAQNKLGS 576
TP K WV + +P V +L V GL + + +A+N +G+
Sbjct: 368 -PTPTVK--------WVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGN 418
Query: 577 GPF-SEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVP- 634
+++++ L PA G P P +P + ++ + R + L W P P
Sbjct: 419 AQAGAQLII-----LEHAPATTG------PLPSAPRDVVASLVSTRFIKLTWRTPASDPH 467
Query: 635 -KRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSN 693
L V ++G V + + G E ++ + L+ +Y FR++A + S
Sbjct: 468 GDNLTYSVFYTKEGIARERVENTSHPG-EMQVTIQNLMPATVYIFRVMAQNKHGSGESSA 526
Query: 694 TANVSTSGLEVYPSRTQLPGLLP 716
V T QLPG P
Sbjct: 527 PLRVETQ------PEVQLPGPAP 543
Score = 52.4 bits (124), Expect = 3e-06
Identities = 50/211 (23%), Positives = 83/211 (39%), Gaps = 35/211 (16%)
Query: 24 PEVVS----------VVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLY 73
PEV+S +V G+ VVL C A P I+W++
Sbjct: 243 PEVISDLVFLKQPSPLVRVIGQDVVLPC----VASGLPTPTIKWMK-------------N 285
Query: 74 SPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVN 133
+D + R+ L G SL+I + +D G Y C ++ I + LTV
Sbjct: 286 EEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE-------AQAELTVQ 338
Query: 134 SPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRI 193
+ P+F + P + + ++ + C G P P V W G + V+ L++
Sbjct: 339 AQPEFLKQPTNIYAHESMD-IVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQV 397
Query: 194 RRVERGSSGVYTCQASSTEGSATHATQLLVL 224
+ + G Y C A + G+A QL++L
Sbjct: 398 LGLVKSDEGFYQCIAENDVGNAQAGAQLIIL 428
Score = 40.0 bits (92), Expect = 0.013
Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 5/113 (4%)
Query: 473 SNAVARVATSTNVYVLGTSPHV-VTNVSVVALPKGANVSWEPGFDG-GYLQRFSVWYTPL 530
S+ + A T ++ TSP VT VS PK V+W+P + G + + ++Y+
Sbjct: 938 SSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTD 997
Query: 531 AKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 583
HDWV V + L T Y F + A+N G GP SE V
Sbjct: 998 VNAEI---HDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAV 1047
Score = 39.3 bits (90), Expect = 0.022
Identities = 34/136 (25%), Positives = 56/136 (41%), Gaps = 24/136 (17%)
Query: 554 LVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRG 613
LV GL+P+T Y+FSV+ S +S L P SPP+
Sbjct: 916 LVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFEL---------------VPTSPPKD 960
Query: 614 LVAVR---TPRGVLLHWDPPELVPKRLDGYVL----EGRQGSQGWEVLDPAVAGTETELL 666
+ V P+ ++++W PP ++ GY++ + W V++P V G
Sbjct: 961 VTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDW-VIEP-VVGNRLTHQ 1018
Query: 667 VPGLIKDVLYEFRLVA 682
+ L D Y F++ A
Sbjct: 1019 IQELTLDTPYYFKIQA 1034
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 117 bits (294), Expect = 5e-26
Identities = 171/702 (24%), Positives = 271/702 (38%), Gaps = 86/702 (12%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72
++++GA K V V GESVVL C+ PP PL + W+ L
Sbjct: 125 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 172
Query: 73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126
I D RV + + +L + D Y C F + Q P D +
Sbjct: 173 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 227
Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186
+ F + L + +P+ L C+A G P P + W + + Q
Sbjct: 228 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 287
Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
N TL++ +V G Y C A ++ GSA HA + V P + P++ + L
Sbjct: 288 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 347
Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305
C + P +W + I V +++ Q + RI G+L L QP D C N
Sbjct: 348 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 404
Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRA-----------------NPPLLFVSW-TKDG- 345
GLL A+AY+ V+ +P I P+ V W +DG
Sbjct: 405 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 461
Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
LQ ++F ++ GT G I L D G Y C N + + + +K
Sbjct: 462 TVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQIT 516
Query: 406 ERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILRP 459
+ P+ ++ G + C A DP P ++W GR LQ D + L++
Sbjct: 517 QGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHS 575
Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGFD 516
L G++ C AS + V + + V+G+ P +V + + VSW P D
Sbjct: 576 LDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAED 635
Query: 517 -GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575
++++ + + P++ W SL G L P+ Y F V A NK G
Sbjct: 636 HNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYG 691
Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635
G S + E + T AAP P ++ + +V P + W+ P++
Sbjct: 692 PGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV--- 743
Query: 636 RLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 672
Y ++ R QG++G W+ V DP + + T VP IK
Sbjct: 744 ---QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 782
Score = 90.1 bits (222), Expect = 1e-17
Identities = 137/576 (23%), Positives = 221/576 (38%), Gaps = 75/576 (13%)
Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214
L C A G+P+P V W G + Q + NGTL IR ++ +G Y C A++ + +
Sbjct: 441 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 500
Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273
T L V I P+++ V+ C A P+ + +W D ++ +
Sbjct: 501 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 560
Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRAN 333
+ DG L + + D G Y+CV S L + A L V+ PG + V ++
Sbjct: 561 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTEL-DVVESRAQLLVVGSPGPVPRLVLSD 617
Query: 334 PPLLF-----VSWTK---------------DGKALQLDKFP--GWSQGTEGSLIIALGNE 371
LL VSW+ + K + +K+ G G + S + L +
Sbjct: 618 LHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SP 676
Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA-- 426
+ T N G PSPV+ ++ A + P + + G E ++I
Sbjct: 677 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLR 734
Query: 427 --QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVAT 481
+ P V V W G Q Q+ S+ L++ + + A N+ +
Sbjct: 735 WMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPE 794
Query: 482 S--TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAK 532
T Y P + + + + + V W P G+L+ ++V W +
Sbjct: 795 PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQR 854
Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592
+ + H + VP +++ GL+P++ Y V A N GSGP SE S PEG+P
Sbjct: 855 KHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPG 914
Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQ 646
P A L ++ +LL W PP L GYVL EG +
Sbjct: 915 HPEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGK 958
Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682
G + + DP + L P L Y F+L A
Sbjct: 959 GQLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 990
Score = 68.6 bits (166), Expect = 3e-11
Identities = 95/410 (23%), Positives = 157/410 (38%), Gaps = 61/410 (14%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQVQN 188
PP E P L V + ++L+C A G P W G ++LG Q +
Sbjct: 29 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-SPHS 87
Query: 189 GTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST----VN 239
G+ I + G+Y C AS+ G+A +H +L+ G P PK + V
Sbjct: 88 GSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPVEVE 144
Query: 240 ASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQPDD 295
+ V L C+ L W N + HI + RV + +G+L L + D
Sbjct: 145 EGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDNHSD 201
Query: 296 AGCYTCVPSN------------------------GLLHPPSASAYLTVL-CMPGVIRCPV 330
C+ P LL P ++S++L L P V+ C +
Sbjct: 202 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLEC-I 260
Query: 331 RANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGP 390
P + W + + D+ + + ++ +G ED GEY C NSLG+A
Sbjct: 261 AEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEEDD-GEYRCLAENSLGSA-- 316
Query: 391 SPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD 450
V ++A P ++ +P+ + G + C QG P P V+W G ++ A+
Sbjct: 317 RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQ 375
Query: 451 ----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVT 496
+LIL + +C A N + + +YV+ ++T
Sbjct: 376 KYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 425
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 117 bits (294), Expect = 5e-26
Identities = 171/702 (24%), Positives = 271/702 (38%), Gaps = 86/702 (12%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72
++++GA K V V GESVVL C+ PP PL + W+ L
Sbjct: 130 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 177
Query: 73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126
I D RV + + +L + D Y C F + Q P D +
Sbjct: 178 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 232
Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186
+ F + L + +P+ L C+A G P P + W + + Q
Sbjct: 233 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 292
Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
N TL++ +V G Y C A ++ GSA HA + V P + P++ + L
Sbjct: 293 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 352
Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305
C + P +W + I V +++ Q + RI G+L L QP D C N
Sbjct: 353 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 409
Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRA-----------------NPPLLFVSW-TKDG- 345
GLL A+AY+ V+ +P I P+ V W +DG
Sbjct: 410 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466
Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
LQ ++F ++ GT G I L D G Y C N + + + +K
Sbjct: 467 TVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQIT 521
Query: 406 ERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILRP 459
+ P+ ++ G + C A DP P ++W GR LQ D + L++
Sbjct: 522 QGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHS 580
Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGFD 516
L G++ C AS + V + + V+G+ P +V + + VSW P D
Sbjct: 581 LDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAED 640
Query: 517 -GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575
++++ + + P++ W SL G L P+ Y F V A NK G
Sbjct: 641 HNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYG 696
Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635
G S + E + T AAP P ++ + +V P + W+ P++
Sbjct: 697 PGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV--- 748
Query: 636 RLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 672
Y ++ R QG++G W+ V DP + + T VP IK
Sbjct: 749 ---QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 787
Score = 90.1 bits (222), Expect = 1e-17
Identities = 137/576 (23%), Positives = 221/576 (38%), Gaps = 75/576 (13%)
Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214
L C A G+P+P V W G + Q + NGTL IR ++ +G Y C A++ + +
Sbjct: 446 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 505
Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273
T L V I P+++ V+ C A P+ + +W D ++ +
Sbjct: 506 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 565
Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRAN 333
+ DG L + + D G Y+CV S L + A L V+ PG + V ++
Sbjct: 566 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTEL-DVVESRAQLLVVGSPGPVPRLVLSD 622
Query: 334 PPLLF-----VSWTK---------------DGKALQLDKFP--GWSQGTEGSLIIALGNE 371
LL VSW+ + K + +K+ G G + S + L +
Sbjct: 623 LHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SP 681
Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA-- 426
+ T N G PSPV+ ++ A + P + + G E ++I
Sbjct: 682 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLR 739
Query: 427 --QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVAT 481
+ P V V W G Q Q+ S+ L++ + + A N+ +
Sbjct: 740 WMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPE 799
Query: 482 S--TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAK 532
T Y P + + + + + V W P G+L+ ++V W +
Sbjct: 800 PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQR 859
Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592
+ + H + VP +++ GL+P++ Y V A N GSGP SE S PEG+P
Sbjct: 860 KHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPG 919
Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQ 646
P A L ++ +LL W PP L GYVL EG +
Sbjct: 920 HPEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGK 963
Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682
G + + DP + L P L Y F+L A
Sbjct: 964 GQLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 995
Score = 69.3 bits (168), Expect = 2e-11
Identities = 96/413 (23%), Positives = 158/413 (38%), Gaps = 61/413 (14%)
Query: 132 VNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQ 185
V PP E P L V + ++L+C A G P W G ++LG Q
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-S 89
Query: 186 VQNGTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST--- 237
+G+ I + G+Y C AS+ G+A +H +L+ G P PK +
Sbjct: 90 PHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPV 146
Query: 238 -VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQ 292
V + V L C+ L W N + HI + RV + +G+L L +
Sbjct: 147 EVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDN 203
Query: 293 PDDAGCYTCVPSN------------------------GLLHPPSASAYLTVL-CMPGVIR 327
D C+ P LL P ++S++L L P V+
Sbjct: 204 HSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLE 263
Query: 328 CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGT 387
C + P + W + + D+ + + ++ +G ED GEY C NSLG+
Sbjct: 264 C-IAEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEEDD-GEYRCLAENSLGS 320
Query: 388 AGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQA 447
A V ++A P ++ +P+ + G + C QG P P V+W G ++ A
Sbjct: 321 A--RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQPEVTWRINGIPVEELA 377
Query: 448 QVD----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVT 496
+ +LIL + +C A N + + +YV+ ++T
Sbjct: 378 KDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 430
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 117 bits (294), Expect = 5e-26
Identities = 171/702 (24%), Positives = 271/702 (38%), Gaps = 86/702 (12%)
Query: 13 VISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGL 72
++++GA K V V GESVVL C+ PP PL + W+ L
Sbjct: 130 LMAEGAPKWPKETVKPVEVEEGESVVLPCN--PPPSAEPLRIY-WMNSKIL--------- 177
Query: 73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQ-GWYECRVFF-----LDQHIPEDDFANGS 126
I D RV + + +L + D Y C F + Q P D +
Sbjct: 178 ---HIKQDE--RVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 232
Query: 127 WVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186
+ F + L + +P+ L C+A G P P + W + + Q
Sbjct: 233 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQN 292
Query: 187 QNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSL 246
N TL++ +V G Y C A ++ GSA HA + V P + P++ + L
Sbjct: 293 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARL 352
Query: 247 ACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN- 305
C + P +W + I V +++ Q + RI G+L L QP D C N
Sbjct: 353 DCQVQGRP-QPEVTWRINGIPVEELAKDQ-KYRI-QRGALILSNVQPSDTMVTQCEARNR 409
Query: 306 -GLLHPPSASAYLTVLCMPGVIRCPVRA-----------------NPPLLFVSW-TKDG- 345
GLL A+AY+ V+ +P I P+ V W +DG
Sbjct: 410 HGLL---LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466
Query: 346 KALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFI 405
LQ ++F ++ GT G I L D G Y C N + + + +K
Sbjct: 467 TVLQDERFFPYANGTLG--IRDLQANDT-GRYFCLAANDQNNV--TIMANLKVKDATQIT 521
Query: 406 ERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD----SNSSLILRP 459
+ P+ ++ G + C A DP P ++W GR LQ D + L++
Sbjct: 522 QGPRST-IEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHS 580
Query: 460 LTKEAHGHWECSASNAVARVATSTNVYVLGTS---PHVVTNVSVVALPKGANVSWEPGFD 516
L G++ C AS + V + + V+G+ P +V + + VSW P D
Sbjct: 581 LDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAED 640
Query: 517 -GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575
++++ + + P++ W SL G L P+ Y F V A NK G
Sbjct: 641 HNAPIEKYDIEFEDKEMAPEK----WYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYG 696
Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPK 635
G S + E + T AAP P ++ + +V P + W+ P++
Sbjct: 697 PGEPSPV----SETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR-WMDWNAPQV--- 748
Query: 636 RLDGYVLEGR-QGSQG-WE---VLDPAVAGTETELLVPGLIK 672
Y ++ R QG++G W+ V DP + + T VP IK
Sbjct: 749 ---QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIK 787
Score = 90.1 bits (222), Expect = 1e-17
Identities = 137/576 (23%), Positives = 221/576 (38%), Gaps = 75/576 (13%)
Query: 156 LRCVARGSPLPHVTWKLR-GKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS 214
L C A G+P+P V W G + Q + NGTL IR ++ +G Y C A++ + +
Sbjct: 446 LLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNN 505
Query: 215 ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA-NLTYSWFQDNINVFHISR 273
T L V I P+++ V+ C A P+ + +W D ++ +
Sbjct: 506 VTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGD 565
Query: 274 LQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRAN 333
+ DG L + + D G Y+CV S L + A L V+ PG + V ++
Sbjct: 566 SDKY--FIEDGRLVIHSLDYSDQGNYSCVASTEL-DVVESRAQLLVVGSPGPVPRLVLSD 622
Query: 334 PPLLF-----VSWTK---------------DGKALQLDKFP--GWSQGTEGSLIIALGNE 371
LL VSW+ + K + +K+ G G + S + L +
Sbjct: 623 LHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL-SP 681
Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE---LLIPCSA-- 426
+ T N G PSPV+ ++ A + P + + G E ++I
Sbjct: 682 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD--VKGEGNETTNMVITWKPLR 739
Query: 427 --QGDPPPV---VSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVAT 481
+ P V V W G Q Q+ S+ L++ + + A N+ +
Sbjct: 740 WMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPE 799
Query: 482 S--TNVYVLGTSPHVVTNVSVVALPKGANV--SWEP---GFDGGYLQRFSV--WYTPLAK 532
T Y P + + + + + V W P G+L+ ++V W +
Sbjct: 800 PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQR 859
Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592
+ + H + VP +++ GL+P++ Y V A N GSGP SE S PEG+P
Sbjct: 860 KHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPG 919
Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVL------EGRQ 646
P A L ++ +LL W PP L GYVL EG +
Sbjct: 920 HPEALHL----------------ECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGK 963
Query: 647 GSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682
G + + DP + L P L Y F+L A
Sbjct: 964 GQLSFNLRDPELRTHNLTDLSPHL----RYRFQLQA 995
Score = 69.3 bits (168), Expect = 2e-11
Identities = 96/413 (23%), Positives = 158/413 (38%), Gaps = 61/413 (14%)
Query: 132 VNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KDLGQGQGQVQ 185
V PP E P L V + ++L+C A G P W G ++LG Q
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQ-S 89
Query: 186 VQNGTLRI----RRVERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNST--- 237
+G+ I + G+Y C AS+ G+A +H +L+ G P PK +
Sbjct: 90 PHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPV 146
Query: 238 -VNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLATQ 292
V + V L C+ L W N + HI + RV + +G+L L +
Sbjct: 147 EVEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQ-DERVTMGQNGNLYFANVLTSDN 203
Query: 293 PDDAGCYTCVPSN------------------------GLLHPPSASAYLTVL-CMPGVIR 327
D C+ P LL P ++S++L L P V+
Sbjct: 204 HSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLE 263
Query: 328 CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGT 387
C + P + W + + D+ + + ++ +G ED GEY C NSLG+
Sbjct: 264 C-IAEGFPTPTIKWLRPSGPMPADRVT-YQNHNKTLQLLKVGEEDD-GEYRCLAENSLGS 320
Query: 388 AGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQA 447
A V ++A P ++ +P+ + G + C QG P P V+W G ++ A
Sbjct: 321 A--RHAYYVTVEAAPYWLHKPQSHLYGP-GETARLDCQVQGRPQPEVTWRINGIPVEELA 377
Query: 448 QVD----SNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVT 496
+ +LIL + +C A N + + +YV+ ++T
Sbjct: 378 KDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 430
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 117 bits (294), Expect = 5e-26
Identities = 94/365 (25%), Positives = 150/365 (41%), Gaps = 35/365 (9%)
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQ--VQNGTLRIRRVERGS 200
P +V V C A G+P P + W +L + +GTL I+ +
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311
Query: 201 SGVYTCQASSTEGSA-THATQLLVLGPPV---IVVPPKNSTVNASQDVSLACHAEAYPAN 256
G+Y C A + G T L G P V+ P+N+ V + V+L C A +P
Sbjct: 312 QGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPP 371
Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
SW + + + PRV I G L + D+G Y C +N + A+A+
Sbjct: 372 -RISWTRGDRTPLPVD---PRVNITPSGGLYIQNVVQGDSGEYACSATNNI-DSVHATAF 426
Query: 317 LTVLCMPGV----------------IRCPVRANPPLLFVSWTKDGKALQLDK-FPGWSQG 359
+ V +P +C + NPP + ++WTK G L +D+ S G
Sbjct: 427 IIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPV-IAWTKGGSQLSVDRRHLVLSSG 485
Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
T +AL ++ G+Y C N +G+ V + P F P + EVG
Sbjct: 486 TLRISGVALHDQ---GQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV-EVGAN 541
Query: 420 LLIPCSAQGDPPPVVSWTKVGRGL--QGQAQVDSNSSLILRPLTKEAHGHWECSASNAVA 477
+ +PCS+QG+P P ++W K G + G+ + L + + G +EC A N +
Sbjct: 542 VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601
Query: 478 RVATS 482
+ S
Sbjct: 602 SASVS 606
Score = 84.3 bits (207), Expect = 6e-16
Identities = 82/279 (29%), Positives = 112/279 (40%), Gaps = 43/279 (15%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
GESV L C G PP I W R G P+ +DP RV + L
Sbjct: 356 GESVTLECSA---TGHPPPR-ISWTR-GDRTPL---------PVDP----RVNITPSGGL 397
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I+ + D G Y C + F + V + PQF TP + + E +
Sbjct: 398 YIQNVVQGDSGEYACSATNNIDSVHATAF-------IIVQALPQFTVTPQDRVVI-EGQT 449
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEG 213
V +C A+G+P P + W G L + + + +GTLRI V G Y CQA + G
Sbjct: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509
Query: 214 SATHATQLLVLG--PPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV--- 268
S L V PV P ++TV +V L C ++ P +W +D + V
Sbjct: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEP-EPAITWNKDGVQVTES 568
Query: 269 --FHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN 305
FHIS +G L + P DAG Y CV N
Sbjct: 569 GKFHIS---------PEGFLTINDVGPADAGRYECVARN 598
Score = 79.7 bits (195), Expect = 1e-14
Identities = 87/332 (26%), Positives = 135/332 (40%), Gaps = 32/332 (9%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R+ L +L I+ + DQG Y+C + + + + + + P F P
Sbjct: 293 RLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEV---TLRYFGSPARPTF-VIQP 348
Query: 144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV-QNGTLRIRRVERGSSG 202
EV E VTL C A G P P ++W + +V + +G L I+ V +G SG
Sbjct: 349 QNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSG 408
Query: 203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWF 262
Y C A++ S ++V P V P++ V Q V C A+ P + +W
Sbjct: 409 EYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPV-IAWT 467
Query: 263 QDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV--- 319
+ + + R +L G+LR+ D G Y C N ++ A+LTV
Sbjct: 468 KGGSQL----SVDRRHLVLSSGTLRISGVALHDQGQYECQAVN-IIGSQKVVAHLTVQPR 522
Query: 320 -----LCMPGVIRCPVRAN---------PPLLFVSWTKDGKALQLDKFPGWSQGTEGSLI 365
+P V AN P ++W KDG +Q+ + + EG L
Sbjct: 523 VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG--VQVTESGKFHISPEGFLT 580
Query: 366 I-ALGNEDALGEYSCTPYNSLGTAGPSPVTRV 396
I +G DA G Y C N++G+A S V V
Sbjct: 581 INDVGPADA-GRYECVARNTIGSASVSMVLSV 611
Score = 61.6 bits (148), Expect = 4e-09
Identities = 63/282 (22%), Positives = 107/282 (37%), Gaps = 15/282 (5%)
Query: 328 CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGT 387
C NP + W ++ L + + +G+L+I E G Y C N G
Sbjct: 267 CRAEGNPKPEII-WLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGE 325
Query: 388 AGPSPVTRVLLKAP--PAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRG--- 442
VT +P P F+ +P+ VG + + CSA G PPP +SWT+ R
Sbjct: 326 VKTQEVTLRYFGSPARPTFVIQPQNTEVL-VGESVTLECSATGHPPPRISWTRGDRTPLP 384
Query: 443 LQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVA 502
+ + + + L ++ + + G + CSA+N + V + + V VT V
Sbjct: 385 VDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVV 444
Query: 503 LPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHT 562
+ +G V ++ G + DR H + + + L + G+ H
Sbjct: 445 I-EGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRH-------LVLSSGTLRISGVALHD 496
Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEI 604
Q Q+ A N +GS + P P + P E+
Sbjct: 497 QGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEV 538
Score = 48.5 bits (114), Expect = 4e-05
Identities = 56/200 (28%), Positives = 82/200 (41%), Gaps = 35/200 (17%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G++V C+ G PP VI W + G L + + + S +L
Sbjct: 447 GQTVDFQCEA---KGNPP-PVIAWTKGGSQLSVDRRHLVLS---------------SGTL 487
Query: 94 QIEGLRVEDQGWYECRVFFL--DQHIPEDDFANGSWVHLTVNS--PPQFQETPPAVLEVQ 149
+I G+ + DQG YEC+ + Q + HLTV P F P V+
Sbjct: 488 RISGVALHDQGQYECQAVNIIGSQKVV---------AHLTVQPRVTPVFASIPSDTT-VE 537
Query: 150 ELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-NGTLRIRRVERGSSGVYTCQA 208
V L C ++G P P +TW G + + G+ + G L I V +G Y C A
Sbjct: 538 VGANVQLPCSSQGEPEPAITWNKDGVQVTES-GKFHISPEGFLTINDVGPADAGRYECVA 596
Query: 209 SSTEGSATHATQLLVLGPPV 228
+T GSA+ + L V P V
Sbjct: 597 RNTIGSASVSMVLSVNVPDV 616
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 115 bits (289), Expect = 2e-25
Identities = 153/651 (23%), Positives = 245/651 (37%), Gaps = 101/651 (15%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G+ +VL C+ PP G PPLH+ W+ I+ D RV + + L
Sbjct: 146 GDPIVLPCN--PPKGLPPLHIY-WMNIEL------------EHIEQDE--RVYMSQKGDL 188
Query: 94 QIEGLRVEDQGWYEC------RVFFLDQHIP----------EDDFANGSWVHLTVNSPPQ 137
+ +D C R+ + Q +P +D ++ + + NS Q
Sbjct: 189 YFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQ 248
Query: 138 FQET---PP------AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN 188
+ PP + + + + E + L C A G P P V W G DL +G+ +
Sbjct: 249 RKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYG 308
Query: 189 GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248
TL+I V G Y C AS+ G+ATH ++V PP P+++ + + L C
Sbjct: 309 KTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLC 368
Query: 249 HAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSN--- 305
AE P T W +N + ++ + QP+ Y C SN
Sbjct: 369 EAEGEP-QPTIKW---RVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHG 424
Query: 306 --------------GLLHPPSASAYLTVLCMPGVIRCPVRANPPLLFVSWTK--DGKALQ 349
L+ Y TV+ + C A+P + VSW K + K L+
Sbjct: 425 TILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAV-VSWQKVEEVKPLE 483
Query: 350 LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLG----TAGPSPVTRVLLKAPPAFI 405
++ + GT L I E+ G YSC N++G TA L+ P
Sbjct: 484 GRRYHIYENGT---LQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSP--- 537
Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD-----SNSSLILRPL 460
+ P+ + C + +SW+K G + D ++L + +
Sbjct: 538 KNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNV 597
Query: 461 TKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-KGANVSWEPGFD-GG 518
T E G + CSA A+ A T V VL P N+ + + ++WE G D
Sbjct: 598 TLEDQGIYCCSAHTALDSAADITQVTVLDV-PDPPENLHLSERQNRSVRLTWEAGADHNS 656
Query: 519 YLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGP 578
+ + V + + P R W L G ++ L P +YQF V+A N++G
Sbjct: 657 NISEYIVEFEGNKEEPGR----WEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQ 712
Query: 579 FSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 629
S+ + T PAAP P I V P+ +++ W+P
Sbjct: 713 PSQ----PSDHHETPPAAPDRNPQNI---------RVQASQPKEMIIKWEP 750
Score = 79.3 bits (194), Expect = 2e-14
Identities = 175/755 (23%), Positives = 279/755 (36%), Gaps = 140/755 (18%)
Query: 43 LLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG-------RVRLQKGASLQI 95
LLPP I L+ LL GL +P++D + +G + G +L+I
Sbjct: 254 LLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKI 313
Query: 96 EGLRVEDQGWYECRVF-FLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPV 154
E + +D+G Y C FL DF H+ V PP++ + P + + +
Sbjct: 314 ENVSYQDKGNYRCTASNFLGT--ATHDF------HVIVEEPPRWTKKPQSAVYSTGSNGI 365
Query: 155 TLRCVARGSPLPHVTWKLRGKDLGQGQ--GQVQVQNGTLRIRRVERGSSGVYTCQASSTE 212
L C A G P P + W++ G + G V V + ++ + VY C+AS+
Sbjct: 366 LL-CEAEGEPQPTIKWRVNGSPVDNHPFAGDV-VFPREISFTNLQPNHTAVYQCEASNVH 423
Query: 213 GS--ATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFH 270
G+ A ++ + P + +N L C A P + SW +
Sbjct: 424 GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVV-SWQK------- 475
Query: 271 ISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGL--------LHPPSASAYLT 318
+ ++P R I +G+L++ T +DAG Y+C N + L +A+
Sbjct: 476 VEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRV 535
Query: 319 VLCMPGV-------IRCPVRANPPL---LFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 368
P + + C + + L L +SW+KDG+A +++ GTE II
Sbjct: 536 SPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEIN-------GTEDGRIIID 588
Query: 369 GNEDAL--------GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQE-VGRE 419
G + G Y C+ + +L +A + +T+V + P + P+ + E R
Sbjct: 589 GANLTISNVTLEDQGIYCCSAHTALDSA--ADITQVTVLDVP---DPPENLHLSERQNRS 643
Query: 420 LLIPCSAQGDPPPVVSWTKV---------GRGLQGQAQVDSNSSLILRPLTKEAHGHWEC 470
+ + A D +S V GR + +V + ++ PL +
Sbjct: 644 VRLTWEAGADHNSNISEYIVEFEGNKEEPGRW-EELTRVQGKKTTVILPLAPFVRYQFRV 702
Query: 471 SASNAVARVATSTNVYVLGTSPHVVT----NVSVVAL-PKGANVSWEP----GFDGGYLQ 521
A N V R S T P N+ V A PK + WEP +G L+
Sbjct: 703 IAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLE 762
Query: 522 RFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSE 581
W +P +W V ++ P + + Y V A N+LGSGP
Sbjct: 763 YRVTW------KPQGAPVEWEEETVTNHTLRVMTPAV--YAPYDVKVQAINQLGSGP--- 811
Query: 582 IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD--PPELVPKRLDG 639
P + L E P +P V V V + W P + V RL G
Sbjct: 812 -----------DPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKG 860
Query: 640 Y---------VLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSD 690
Y +L+GR + +L +G +VP L D EF L A
Sbjct: 861 YQINWWKTKSLLDGRTHPKEVNIL--RFSGQRNSGMVPSL--DAFSEFHLTVLA------ 910
Query: 691 PSNTANVSTSGLEVYPSRTQLP-GLLPQPVLAGVV 724
N +G E P Q P G+ QP V+
Sbjct: 911 ----YNSKGAGPESEPYIFQTPEGVPEQPTFLKVI 941
Score = 57.0 bits (136), Expect = 1e-07
Identities = 95/417 (22%), Positives = 147/417 (35%), Gaps = 73/417 (17%)
Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRC-VARGSPLPHVTW-KLRGKDLGQGQGQVQ 185
+ V S P+F + LEV+E +P+ L C +G P H+ W + + + Q +
Sbjct: 123 IEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYM 182
Query: 186 VQNGTLRIRRV-ERGSSGVYTCQAS--------------STEGSATHA------------ 218
Q G L V E+ S Y C A+ T S HA
Sbjct: 183 SQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSK 242
Query: 219 TQLLVLGPPVIVVPPKNS------TVNASQDVSLACHAEAYPANLTYSWFQDNINVFHIS 272
+ P +++PP S T+ + + L C AE P ++ I
Sbjct: 243 ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPT--------PQVDWNKIG 294
Query: 273 RLQPRVRILVDG---SLRLLATQPDDAGCYTCVPSNGL-----------------LHPPS 312
P+ R + +L++ D G Y C SN L P
Sbjct: 295 GDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQ 354
Query: 313 ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-WSQGTEGSLIIALGNE 371
++ Y T G++ C P + W +G + F G E S N
Sbjct: 355 SAVYST--GSNGILLCEAEGEPQPT-IKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNH 411
Query: 372 DALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPP 431
A+ Y C N GT + V + P + E Y VG + C P
Sbjct: 412 TAV--YQCEASNVHGTILANANIDV-VDVRPLIQTKDGENYATVVGYSAFLHCEFFASPE 468
Query: 432 PVVSWTKVG--RGLQGQA-QVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNV 485
VVSW KV + L+G+ + N +L + T+E G + C NA+ + A + N+
Sbjct: 469 AVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANL 525
Score = 40.8 bits (94), Expect = 0.008
Identities = 33/112 (29%), Positives = 50/112 (44%), Gaps = 17/112 (15%)
Query: 390 PSPVTRV--LLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRG--LQG 445
PS V +V ++K + P +EYFQ I C A+G+P P SWTK G
Sbjct: 28 PSSVQQVPTIIKQSKVQVAFPFDEYFQ-------IECEAKGNPEPTFSWTKDGNPFYFTD 80
Query: 446 QAQVDSNSSLILRPLTKEAH-----GHWECSASNAVARVATSTNVYVLGTSP 492
+ SN+S R + E H G + C ASN + + +++ + P
Sbjct: 81 HRIIPSNNSGTFR-IPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVP 131
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 115 bits (288), Expect = 2e-25
Identities = 139/582 (23%), Positives = 233/582 (40%), Gaps = 75/582 (12%)
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRI-----RRVE 197
P + V +PV L C A G VTW G + + + + NG+L I RR E
Sbjct: 45 PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGE 104
Query: 198 RGSSGVYTCQASSTEGSATHATQLLVLGP-PVIVVPPKNSTVNASQDVSLACHAEAYPAN 256
+ G Y C A + G+ L L V P ++ V+ AC ++P
Sbjct: 105 QSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPP- 163
Query: 257 LTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
+W N + R+ L G L++ D+G Y C+ + S A
Sbjct: 164 AVITW---EFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEAS 220
Query: 317 LTV------------------------LCMPGVIRCPVRANPPLLFVSWTK-DGKALQLD 351
LTV L V+ C NP + +SW++ D K+ +D
Sbjct: 221 LTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPI-ISWSRLDHKS--ID 277
Query: 352 KFPGWSQGTEGSLIIALGNEDALGEYSC---TPYNSLGTAGPSPVTRVLLKAPPAFIERP 408
F G G+L+I+ G Y C TP T + +T + APP+F+E P
Sbjct: 278 VFNTRVLG-NGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT---VLAPPSFVEWP 333
Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDS-NSSLILRPLTKEAHGH 467
+ G + C A+G P P +SW K GR + ++ NS L++ + E
Sbjct: 334 ESLTRPRAGTARFV-CQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAI 392
Query: 468 WECSASNAVARVATSTNVYVLGTS--PHVVTNVSVVALPKGA-NVSWE-PGFDGGYLQRF 523
++C A N+ + + + V+ + P NV + A ++WE P ++ + +
Sbjct: 393 YQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAY 452
Query: 524 SVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 583
SV Y + + ++++ + + H ++ L+P + Y F ++A +G+ S+ V
Sbjct: 453 SVHY----MKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHV 508
Query: 584 LSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKR--LDGYV 641
T PL PP + R+P +L+ W P +R + Y
Sbjct: 509 TQ---------------NTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYR 553
Query: 642 LEGRQGSQ-GWEVLDPAVAGTETELLVPGLIKDVLYEFRLVA 682
L R ++ +VL+ + GT E L+ GL D +Y R+ A
Sbjct: 554 LSFRLSTENSIQVLE--LPGTTHEYLLEGLKPDSVYLVRITA 593
Score = 45.1 bits (105), Expect = 4e-04
Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 7/122 (5%)
Query: 557 GLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVA 616
GL P +Y +LA N + G ++ +S TP + +PPP P
Sbjct: 679 GLDPRRKYHVRLLAYNNIDDGYQADQTVS-------TPGCVSVRDRMVPPPPPPHHLYAK 731
Query: 617 VRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLY 676
T + LHW P ++ Y + L + +ET +LV GL + Y
Sbjct: 732 ANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKY 791
Query: 677 EF 678
EF
Sbjct: 792 EF 793
Score = 42.7 bits (99), Expect = 0.002
Identities = 59/263 (22%), Positives = 101/263 (38%), Gaps = 36/263 (13%)
Query: 513 PGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQN 572
P F + +++ P+ + + + L + H+LV GL+P+T+Y+F+V
Sbjct: 745 PAFTAAQIINYTIRCNPVG-----LQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHV 799
Query: 573 KLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPL-SPPRGLVAVRTPRGVLLHWDPPE 631
S P+S +V + T P AP PP + L LV+ + P D PE
Sbjct: 800 DQLSSPWSPVVYHS-----TLPEAPAGPPVGVKVTLIEDDTALVSWKPP-------DGPE 847
Query: 632 LVPKRLDGYVLEGRQGSQG-WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSD 690
V R + G W+VL G T L+ L+ +Y ++ A
Sbjct: 848 TVVTRYTILYASRKAWIAGEWQVLHR--EGAITMALLENLVAGNVYIVKISASNEVGEGP 905
Query: 691 PSNTANVSTSGLEVYPSRTQLPGL-------------LPQPVLAGVVGGVCFLGVAVLVS 737
SN+ ++ E S + L L Q + G+ GV +L+
Sbjct: 906 FSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILIC 965
Query: 738 ILAGCLLNRRRAARRRRKRLRQD 760
+L L+ R +A + + Q+
Sbjct: 966 VL--ILIYRSKARKSSASKTAQN 986
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 115 bits (288), Expect = 2e-25
Identities = 122/471 (25%), Positives = 201/471 (42%), Gaps = 92/471 (19%)
Query: 87 LQKGASLQIEGLRVE----------DQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136
L G +++I G+ E D G Y+C F + D+ V L +P
Sbjct: 354 LNPGKNVRITGINHENLIMDHMVKSDGGAYQC--FVRKDKLSAQDYVQ---VVLEDGTPK 408
Query: 137 QFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQ----GQVQVQNGT-- 190
V V EPV+L C +G+PLP +TW L + +G Q+ G
Sbjct: 409 IISAFSEKV--VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 466
Query: 191 --LRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLAC 248
L I + GVY C A+++ G + ++ V G P + P KN T A +D + C
Sbjct: 467 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNITAIAGRDTYIHC 525
Query: 249 HAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPD-DAGCYTCVPSNGL 307
YP + W++ N N+ + Q V +G+L+L Q + D G YTC N L
Sbjct: 526 RVIGYP-YYSIKWYK-NSNLLPFNHRQ--VAFENNGTLKLSDVQKEVDEGEYTC---NVL 578
Query: 308 LHP---PSASAYLTVLCMPGV---------------IRCPVRANPPLLFVSWTKDGKALQ 349
+ P S S ++TV P + I C V + + ++W KDG+ +
Sbjct: 579 VQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPI- 637
Query: 350 LDKFPGWSQGTEGSLIIALGNEDAL-------------GEYSCTPYNSLGTAGPSPVTRV 396
GSL + + N D G Y+C N A +++
Sbjct: 638 -----------PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNE--AAAVEHQSQL 684
Query: 397 LLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRG----------LQGQ 446
+++ PP F+ +P+++ G+ +++ CSA+G P P + W K +G L G+
Sbjct: 685 IVRVPPKFVVQPRDQ-DGIYGKAVILNCSAEGYPVPTIVW-KFSKGAGVPQFQPIALNGR 742
Query: 447 AQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTN 497
QV SN SL+++ + +E G++ C SN V S ++Y+ P ++T+
Sbjct: 743 IQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMYLTVKIPAMITS 792
Score = 95.1 bits (235), Expect = 3e-19
Identities = 155/699 (22%), Positives = 272/699 (38%), Gaps = 127/699 (18%)
Query: 51 PLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVE-DQGWYECR 109
P + I+W + LLP ++ R +V + +L++ ++ E D+G Y C
Sbjct: 531 PYYSIKWYKNSNLLP-------FNHR-------QVAFENNGTLKLSDVQKEVDEGEYTCN 576
Query: 110 VFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLP-HV 168
V Q + VH+TV PP Q P + V + CV LP +
Sbjct: 577 VLVQPQ------LSTSQSVHVTVKVPPFIQ--PFEFPRFSIGQRVFIPCVVVSGDLPITI 628
Query: 169 TWKLRGKDLGQGQGQVQVQN----GTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVL 224
TW+ G+ + G V + N +LRI + +G YTC A + + H +QL+V
Sbjct: 629 TWQKDGRPIPGSLG-VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
Query: 225 GPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINV--FHISRLQPRVRILV 282
PP VV P++ + V L C AE YP F V F L R+++L
Sbjct: 688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLS 747
Query: 283 DGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVI---------------- 326
+GSL + +D+G Y C SN + S S YLTV +P +I
Sbjct: 748 NGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVK-IPAMITSYPNTTLATQGQKKE 806
Query: 327 -RCPVRANPPLLFVSWTKDGKAL--QLDKFPGWSQGTEGSLIIALG-----NEDALGEYS 378
C P++ V W K+ + + ++ ++ ++ +I L ED+ G +S
Sbjct: 807 MSCTAHGEKPII-VRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDS-GFFS 864
Query: 379 CTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELL----------------- 421
C NS G + ++ ++ PP P E ++V +
Sbjct: 865 CHAINSYGE--DRGIIQLTVQEPP----DPPEIEIKDVKARTITLRWTMGFDGNSPITGY 918
Query: 422 -IPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVA 480
I C + D SW R Q++S + + + P + + + A N + +
Sbjct: 919 DIECKNKSD-----SWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMY---AKNRIGKSE 970
Query: 481 TSTNVYVLG-----TSPHVVTNVSVVALPKGANVSW---EPGFDGGYLQRFSVWYTPLAK 532
S + + P ++ ++ + V+W + G ++ + + Y +
Sbjct: 971 PSNELTITADEAAPDGPPQEVHLEPIS-SQSIRVTWKAPKKHLQNGIIRGYQIGYREYS- 1028
Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFS-EIVLSAPEGLP 591
+ +S+ + + L TQY V A N+ G+GP S EI+ + E +P
Sbjct: 1029 TGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVP 1088
Query: 592 TTPAAPGLPPTEIPPPLSPPRGLVAVRT-PRGVLLHWDPPELVPKRLDGYVLEGRQGSQG 650
+ PP + A+ T P + + W L + L+G +L+G +
Sbjct: 1089 S----------------YPPENVQAIATSPESISISWS--TLSKEALNG-ILQGFRVIYW 1129
Query: 651 WEVLD------PAVAGTETELLVPGLIKDVLYEFRLVAF 683
++D + T+ L + GL K Y +++AF
Sbjct: 1130 ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAF 1168
Score = 69.3 bits (168), Expect = 2e-11
Identities = 47/179 (26%), Positives = 79/179 (44%), Gaps = 26/179 (14%)
Query: 418 RELLIPCSAQGDPPPVVSWTKVGRG------LQGQAQVDSNSSLILRPLTKEAHGHWECS 471
+++++PC A GDP P V W K G + G+ + SN S I+R + E G++ C
Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
Query: 472 ASN--AVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDG-----GYLQRFS 524
A+N + + V V P + + + +SW PG +G GY+ ++S
Sbjct: 1361 ANNNWGSDEIILNLQVQVPPDQPRLTVSKTT---SSSITLSWLPGDNGGSSIRGYILQYS 1417
Query: 525 VWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIV 583
+ W S + + L+ T Y+F++ AQN +G G SEI+
Sbjct: 1418 ----------EDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEII 1466
Score = 65.1 bits (157), Expect = 4e-10
Identities = 103/443 (23%), Positives = 167/443 (37%), Gaps = 62/443 (13%)
Query: 84 RVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
R + +L I+ ++ ED G Y R ++ E +N + L V+ P + P
Sbjct: 172 RFLITSTGALYIKDVQNED-GLYNYRCITRHRYTGETRQSNSA--RLFVSDPAN---SAP 225
Query: 144 AVLE------VQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVE 197
++L+ + V L C A G P P W L + G+ Q L I +
Sbjct: 226 SILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL-ELSGRFQKTVTGLLIENIR 284
Query: 198 RGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANL 257
SG Y C+ S+ G+A +L V P + P+ + VSL+C +
Sbjct: 285 PSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTG-TEDQ 343
Query: 258 TYSWFQDNINVFHISRLQPRVRILVDG----SLRLLATQPDDAGCYTCVPSNGLLHPPSA 313
SW+++ L P + + G +L + D G Y C L SA
Sbjct: 344 ELSWYRNG------EILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL---SA 394
Query: 314 SAYLTVLCMPGV-------------------IRCPVRANPPLLFVSWTKDGKALQLDKFP 354
Y+ V+ G + C V+ PL ++WT D +
Sbjct: 395 QDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGT-PLPTITWTLDDDPILKGGSH 453
Query: 355 GWSQ--GTEGSLIIALGNEDAL----GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERP 408
SQ +EG+++ L + G Y CT NS G R+ ++ P + RP
Sbjct: 454 RISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVV--LYQARINVRGPASI--RP 509
Query: 409 KEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL---QGQAQVDSNSSLILRPLTKEA- 464
+ GR+ I C G P + W K L Q ++N +L L + KE
Sbjct: 510 MKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVD 569
Query: 465 HGHWECSASNAVARVATSTNVYV 487
G + C+ +++TS +V+V
Sbjct: 570 EGEYTCNVL-VQPQLSTSQSVHV 591
Score = 45.4 bits (106), Expect = 3e-04
Identities = 53/207 (25%), Positives = 80/207 (38%), Gaps = 31/207 (14%)
Query: 31 GRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYV-GRVRLQK 89
G G++V+L C A P+ I W G P+ P + GR+++
Sbjct: 701 GIYGKAVILNCS----AEGYPVPTIVWK---------FSKGAGVPQFQPIALNGRIQVLS 747
Query: 90 GASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW-VHLTVNSPPQFQETPPAVLEV 148
SL I+ + ED G+Y C+V D A+ S ++LTV P P L
Sbjct: 748 NGSLLIKHVVEEDSGYYLCKV-------SNDVGADVSKSMYLTVKIPAMITSYPNTTLAT 800
Query: 149 QELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQN--------GTLRIRRVERGS 200
Q + + C A G V W+ + + + V TL+I R
Sbjct: 801 QG-QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED 859
Query: 201 SGVYTCQASSTEGSATHATQLLVLGPP 227
SG ++C A ++ G QL V PP
Sbjct: 860 SGFFSCHAINSYGEDRGIIQLTVQEPP 886
Score = 36.6 bits (83), Expect = 0.14
Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 10/84 (11%)
Query: 151 LEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ-------NGTLRIRRVERGSSGV 203
++ + L C A G P P V W KD V + NG+ IR V+ SG
Sbjct: 1300 MKDIVLPCKAVGDPSPAVKWM---KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356
Query: 204 YTCQASSTEGSATHATQLLVLGPP 227
Y+C A++ GS L V PP
Sbjct: 1357 YSCIANNNWGSDEIILNLQVQVPP 1380
Score = 32.0 bits (71), Expect = 3.5
Identities = 16/64 (25%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 242 QDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTC 301
+D+ L C A P+ W +D+ + + R I +GS + + +D+G Y+C
Sbjct: 1301 KDIVLPCKAVGDPSPAV-KWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC 1359
Query: 302 VPSN 305
+ +N
Sbjct: 1360 IANN 1363
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 113 bits (282), Expect = 1e-24
Identities = 139/570 (24%), Positives = 225/570 (39%), Gaps = 67/570 (11%)
Query: 152 EPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR--RVERGSS----GVYT 205
+P+ L C G+P +TW+ G +L + + NG+L IR R+E G S G Y
Sbjct: 57 QPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYE 116
Query: 206 CQASSTEG-SATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD 264
C A + G + ++ V P+ + C P L +W ++
Sbjct: 117 CVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL-ITWEKN 175
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV----- 319
+ I R +L G L++ + +D G + CV SN S A LTV
Sbjct: 176 RV---PIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGS 232
Query: 320 ------------------LCMPGVIRCPVRANPPLLFVSWTK-DGKALQLDKFPGWSQGT 360
+ V+ C NP + VSW++ DG+ + ++ G
Sbjct: 233 GAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI-VSWSRLDGRPIGVE---GIQVLG 288
Query: 361 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGREL 420
G+LII+ G Y C + R++++AP F++ P + + G
Sbjct: 289 TGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHP-QSISRPAGTTA 347
Query: 421 LIPCSAQGDPPPVVSWTKVGRGLQGQAQV---DSNSSLILRPLTKEAHGHWECSASNAVA 477
+ C AQG+PPP V+W K G+ L V ++NS+L + + E ++C A N+
Sbjct: 348 MFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAG 407
Query: 478 RVATSTNVYVLGTS--PHVVTNVSVVALPK-GANVSW-EPGFDGGYLQRFSVWYTPLAKR 533
S + VL P NV V++ VSW EP + + + + A
Sbjct: 408 SSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADP 467
Query: 534 PDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTT 593
P+ + + AV LV L+P T Y F + A G+ S +PT
Sbjct: 468 PELEYQE----AVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSAS---------VPTL 514
Query: 594 PAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV 653
+ G P PPPLS V V + L W+P + + G+ L R S+
Sbjct: 515 ASTLGEAPA--PPPLS-----VRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFT 567
Query: 654 LDPAVAGTETELLVPGLIKDVLYEFRLVAF 683
+ GT + + L +YE +L+A+
Sbjct: 568 GPILLPGTVSSYNLSQLDPTAVYEVKLLAY 597
Score = 69.7 bits (169), Expect = 2e-11
Identities = 84/282 (29%), Positives = 120/282 (42%), Gaps = 29/282 (10%)
Query: 77 IDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPP 136
ID D L KG LQI GLR ED G + C + +I ++G+ LTV+
Sbjct: 179 IDTDNERYTLLPKGV-LQITGLRAEDGGIFHC----VASNIASIRISHGA--RLTVSGSG 231
Query: 137 QFQETPPAVLEVQELEPVT------LRCVARGSPLPHVTW-KLRGKDLGQGQGQVQVQNG 189
PA+L E +T L CVA G+P P V+W +L G+ +G +G + G
Sbjct: 232 SGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGV-EGIQVLGTG 290
Query: 190 TLRIRRVERGSSGVYTCQAS--STEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
L I V SGVY C A+ T T +L+V P V P++ + A
Sbjct: 291 NLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFT 350
Query: 248 CHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-LRLLATQPDDAGCYTCVPSNG 306
C A+ P +W ++ + VR+ + S L + P+D Y CV N
Sbjct: 351 CQAQGEPPP-HVTWLKNG----QVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENS 405
Query: 307 LLHPPSASAYLTVLCMPGVIRCP-----VRANPPLLFVSWTK 343
ASA LTVL G+ P V + + VSW++
Sbjct: 406 -AGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSE 446
Score = 33.9 bits (76), Expect = 0.93
Identities = 26/100 (26%), Positives = 44/100 (44%), Gaps = 9/100 (9%)
Query: 390 PSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGL--QGQA 447
P+P + A AF P ++ G+ +++ C +G PP ++W K G L +
Sbjct: 30 PAPSEGLGHSAELAFAVEPSDDVAVP-GQPIVLDCRVEGTPPVRITWRKNGVELPESTHS 88
Query: 448 QVDSNSSLILRPLTKEA------HGHWECSASNAVARVAT 481
+ +N SL++R E G +EC A N V +
Sbjct: 89 TLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVS 128
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
[Homo sapiens]
Length = 1250
Score = 111 bits (277), Expect = 5e-24
Identities = 142/582 (24%), Positives = 225/582 (38%), Gaps = 79/582 (13%)
Query: 160 ARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRR--VERGSS-----------GVYTC 206
A P VTW G L + + NG+L + + GS G Y+C
Sbjct: 62 AAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSC 121
Query: 207 QASSTEGSATHATQLLVLGPPV-IVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDN 265
A G T ++ L + P++ TV + CH E PA + +W +D
Sbjct: 122 LAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPII-TWEKDQ 180
Query: 266 INVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYL-------- 317
+ + +PR+ +L +G L++L Q DAG Y CV +N S A L
Sbjct: 181 VTLPE----EPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSL 236
Query: 318 -----------------TVLCMPGVIRCPVRANPPLLFVSWTK-DGKALQLDKFPGWSQG 359
TV+ V+ V + P FVSW + DGK + D
Sbjct: 237 ASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRT- 295
Query: 360 TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
+L+IA G Y C + + + A PA + P E +
Sbjct: 296 ---NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAP-EALSRTRAST 351
Query: 420 LLIPCSAQGDPPPVVSWTKVGRGLQGQAQVD---SNSSLILRPLTKEAHGHWECSASNA- 475
C A G+P P + W G L+ +V SL++ + + G+++C A N+
Sbjct: 352 ARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSA 411
Query: 476 -VARVATSTNVYVLGTSPHVVTNVSVVALPKGAN-VSWE-PGFDGGYLQRFSVWYTPLAK 532
+A A S V V P T V+ L A V+WE P + FS+ Y A+
Sbjct: 412 GMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQK-AR 470
Query: 533 RPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPT 592
D + + + AV L V L+P+T Y+F V+A ++LG+ S
Sbjct: 471 GMDNVEYQF---AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTS------------ 515
Query: 593 TPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP--PELVPKRLDGYVLEGRQGSQG 650
P L T P + P+ ++ P + + W P P L ++ Y +E G +
Sbjct: 516 ---TPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKED 572
Query: 651 WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPS 692
++ V G ET+L++ L + +Y R+ A + PS
Sbjct: 573 -QIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPS 613
Score = 83.6 bits (205), Expect = 1e-15
Identities = 145/606 (23%), Positives = 229/606 (37%), Gaps = 99/606 (16%)
Query: 143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSG 202
P V+E C G P P +TW+ L + + + NG L+I V+ +G
Sbjct: 149 PESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAG 208
Query: 203 VYTCQASSTEGSATHATQLLVLG-------------PPVIVVPPKNSTVNASQDVSLACH 249
Y C A T + H +Q +L VIV P+N+TV + Q V + C
Sbjct: 209 PYRCVA--TNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECV 266
Query: 250 AEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLH 309
A A P SW + + + V +L +L + QP +G Y C +
Sbjct: 267 ASADPTPFV-SWVRQD-----GKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTR 320
Query: 310 P-PSASAYLTVLCMPGVIRCP-----VRAN----------PPLLFVSWTKDGKALQLDKF 353
+A+A L VL P + + P RA+ P + W +G L+ +
Sbjct: 321 DFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGR 380
Query: 354 PGWSQGTEGSLIIA-LGNEDALGEYSCTPYNSLGTA----------------GPSPVTRV 396
QG GSL+I +G +DA G Y C NS G A P+ VT
Sbjct: 381 VK-VQGGGGSLVITQIGLQDA-GYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTAT 438
Query: 397 LLKAPPAFI--ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSS 454
L + + ERP+ Q +G L + D ++ Q V+++++
Sbjct: 439 PLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMD------------NVEYQFAVNNDTT 486
Query: 455 -LILRPLTKEAHGHWECSASN--AVARVATSTNVYVLGTSPHVVTNVSVVA-LPKGANVS 510
L +R L + A + +R +T V+ L P +S+ + P V+
Sbjct: 487 ELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVA 546
Query: 511 W---EPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFS 567
W P G + ++ + Y + D++ S V L++ LQP+ Y+
Sbjct: 547 WLPLPPSLSNGQVVKYKIEYG--LGKEDQI----FSTEVRGNETQLMLNSLQPNKVYRVR 600
Query: 568 VLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP------R 621
+ A G G S+ + + P P E+ +V+ + P
Sbjct: 601 ISAGTAAGFGAPSQWMHHRTPSMHNQSHVP-FAPAELKVQAKMESLVVSWQPPPHPTQIS 659
Query: 622 GVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV----LDPAVAGTETELLVPGLIKDVLYE 677
G L+W + +G L G +G Q W+V L V E LVPG LYE
Sbjct: 660 GYKLYWREVG-AEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGR----LYE 714
Query: 678 FRLVAF 683
+LVAF
Sbjct: 715 VKLVAF 720
Score = 61.6 bits (148), Expect = 4e-09
Identities = 101/401 (25%), Positives = 144/401 (35%), Gaps = 85/401 (21%)
Query: 553 LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPR 612
+L+ GL+P T+Y+F+V + GPF +V + T P P PP+++ LSP
Sbjct: 808 ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS-----TLPDRPSTPPSDL--RLSP-- 858
Query: 613 GLVAVRTPRGVLLHWDPP-----ELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLV 667
TP V LHW PP E+V + L Y Q W +L G V
Sbjct: 859 -----LTPSTVRLHWCPPTEPNGEIV-EYLILYSSNHTQPEHQWTLL--TTQGNIFSAEV 910
Query: 668 PGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGV 727
GL D Y F++ A S +V T + +L L + G++ GV
Sbjct: 911 HGLESDTRYFFKMGARTEVGPGPFSRLQDVIT-------LQEKLSDSLDMHSVTGIIVGV 963
Query: 728 CFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPT-GKSAAPSALGSGSPDSVA 786
C LG+ CLL A RR P L + T G A S G P A
Sbjct: 964 C-LGLL--------CLLACMCAGLRRSPHRESLPGLSSTATPGNPALYSRARLGPPSPPA 1014
Query: 787 KLKLQG---------SPVPS----------------------LRQSLLWGDPAG------ 809
+L+ SP PS ++ + W P+G
Sbjct: 1015 AHELESLVHPHPQDWSPPPSDVEDRAEVHSLMGGGVSEGRSHSKRKISWAQPSGLSWAGS 1074
Query: 810 -----TPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRL 864
P P P +R LP G ++ V + +GR+++ P Q
Sbjct: 1075 WAGCELPQAGPRPALTRALLP----PAGTGQTLLLQALVYDAIKGNGRKKSPPACRNQVE 1130
Query: 865 ARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSPLPGPG 905
A S S S L ++D+ P P P P + G G
Sbjct: 1131 AEVIVHSDFSASNGNPDLHLQDLEPEDPLPPEAPDLISGVG 1171
Score = 47.0 bits (110), Expect = 1e-04
Identities = 123/547 (22%), Positives = 200/547 (36%), Gaps = 98/547 (17%)
Query: 224 LGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVD 283
+GP +++ P+ + V + SL A P +T W +D + L +L +
Sbjct: 40 VGPLQVILGPEQAAV---LNCSLGAAAAGPPTRVT--WSKDGDTLLEHDHLH----LLPN 90
Query: 284 GSLRL---LATQPDDA----------GCYTCVPSN--GLLHPPSASAYLTVLC------- 321
GSL L LA D G Y+C+ G+L +A L L
Sbjct: 91 GSLWLSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPE 150
Query: 322 -----MPGVIR--CPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDAL 374
G R C + P + ++W KD + L + P G L I E
Sbjct: 151 SQTVEENGTARFECHIEGLPAPI-ITWEKD--QVTLPEEPRLIVLPNGVLQILDVQESDA 207
Query: 375 GEYSCTPYNSL---------------GTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRE 419
G Y C NS G+ + V++ A P E G+
Sbjct: 208 GPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAP-------ENTTVVSGQS 260
Query: 420 LLIPCSAQGDPPPVVSWTKV-GRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVAR 478
+++ C A DP P VSW + G+ + V ++L++ G + C A+ R
Sbjct: 261 VVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTR 320
Query: 479 -VATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRM 537
AT+ + +P + ++ + + + G + RP+
Sbjct: 321 DFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGR 380
Query: 538 HHDWVSLAVPVGAAHLLVP--GLQPHTQYQFSVLAQNKLGSG-PFSEIVLSAPEGLPTTP 594
+ V G L++ GLQ YQ +A+N G + + + EGLP+ P
Sbjct: 381 ------VKVQGGGGSLVITQIGLQDAGYYQ--CVAENSAGMACAAASLAVVVREGLPSAP 432
Query: 595 AAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVL 654
P + VL+ W+ PE+ +++ G+ L Q ++G + +
Sbjct: 433 TRVTATPL----------------SSSAVLVAWERPEMHSEQIIGFSLH-YQKARGMDNV 475
Query: 655 DP--AVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRT-QL 711
+ AV TEL V L + YEF +VA++ S S A V T L+ PS QL
Sbjct: 476 EYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHT--LDDVPSAAPQL 533
Query: 712 PGLLPQP 718
P P
Sbjct: 534 SLSSPNP 540
Score = 35.0 bits (79), Expect = 0.42
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 4/80 (5%)
Query: 504 PKGANVSWEPGFD-GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHT 562
P + W P + G + + + Y+ +P+ H W L V GL+ T
Sbjct: 861 PSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPE---HQWTLLTTQGNIFSAEVHGLESDT 917
Query: 563 QYQFSVLAQNKLGSGPFSEI 582
+Y F + A+ ++G GPFS +
Sbjct: 918 RYFFKMGARTEVGPGPFSRL 937
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 110 bits (276), Expect = 6e-24
Identities = 164/667 (24%), Positives = 244/667 (36%), Gaps = 108/667 (16%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304
Query: 316 YLTVLCMPGVI----------------RCPVRANP-PLLFVSWTKDGKALQLDKFPG--- 355
LTV P + +C NP P +F W ++G L +
Sbjct: 305 TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQPPQS 362
Query: 356 ---WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIERPK 409
+S G L I +G Y C N G T VT V+ PP I +
Sbjct: 363 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 422
Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ----AQVDSNSSLILRPLTKEAH 465
V ++ C A G P P + W K G + Q Q++ N L +R
Sbjct: 423 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE-NGVLQIRYAKLGDT 481
Query: 466 GHWECSASNAVARVATSTNVYVLG----------TSPHVVTNVSVVALPKGANVS----- 510
G + C AS S + V T P+++ S + P+ +VS
Sbjct: 482 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNTVT 539
Query: 511 --WEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHTQY 564
W+P + G TP + + H W ++A V + GL+P+ Y
Sbjct: 540 LSWQPNLNSGA--------TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIY 591
Query: 565 QFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP--- 620
F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 592 LFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPTVL 647
Query: 621 --RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVPGL 670
+ +HW + + + GY + R G W EV PA + +++P L
Sbjct: 648 SSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIPDL 702
Query: 671 IKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFL 730
K V YE + F F S T LE PS PQ V G
Sbjct: 703 RKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG---N 751
Query: 731 GVAVLVS 737
G A+LVS
Sbjct: 752 GTAILVS 758
Score = 110 bits (274), Expect = 1e-23
Identities = 196/842 (23%), Positives = 291/842 (34%), Gaps = 158/842 (18%)
Query: 19 DGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID 78
D R P V V GE V+ C PP G P I W + G SP D
Sbjct: 132 DFRQNPSDVMVA--VGEPAVMECQ--PPRGHPE-PTISWKKDG------------SPLDD 174
Query: 79 PDYVGRVRLQKGASLQIEGLRVEDQGWYEC----RVFFLDQHIPEDDFANGSWVHLTVNS 134
D +R G L I R D G Y C V + + E LTV
Sbjct: 175 KDERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE----------LTVLE 221
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR 194
P F + P + L V + +C ARG P+P V W+ +L + + +++ + TL+IR
Sbjct: 222 RPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR-DDHTLKIR 279
Query: 195 RVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP 254
+V G G YTC A + G A + L V PP VV P++ V + V+ C A P
Sbjct: 280 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNP 339
Query: 255 ANLTYSWFQDNINVFHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310
+ W ++ S P R + G L + Q D G Y C N +
Sbjct: 340 QPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN-VAGS 397
Query: 311 PSASAYLTVLCM-----PGVIR----------------CPVRANPPLLFVSWTKDGKALQ 349
AYL V + P VIR V P+ + W KDG L
Sbjct: 398 IITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLV 456
Query: 350 LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPK 409
+ Q G L I G Y+C G A S V P RP
Sbjct: 457 STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 516
Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSN---SSLILRPLTKEAHG 466
+ LIP + P V ++ L Q ++S +S I+ + +
Sbjct: 517 DPN--------LIPSAP--SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGS 566
Query: 467 HWECSASNAVARVAT---------------STNVY----------------VLGTSPHV- 494
W+ A N + + N Y VL TS V
Sbjct: 567 SWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 626
Query: 495 --------------VTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHH- 539
+ N +V++ V W Y+Q + + Y RP +H
Sbjct: 627 HKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTVDQQSQYIQGYKILY-----RPSGANHG 680
Query: 540 --DWVSLAVPVGAAH-LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAA 596
DW+ V A + +++P L+ Y+ G SEI + T A
Sbjct: 681 ESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA-----KTLEEA 735
Query: 597 PGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV--- 653
P PP + + G +L+ W PP +G V E + G E
Sbjct: 736 PSAPPQGVTVSKNDGNG-------TAILVSWQPPP--EDTQNGMVQEYKVWCLGNETRYH 786
Query: 654 LDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNTANVSTSGLEVYPS---- 707
++ V G+ +++P L+ + Y + A AGS V + G V P
Sbjct: 787 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS 846
Query: 708 -RTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFS 766
Q+ ++ QP +G C++ + ++ SI +R +R+ P F+
Sbjct: 847 LAQQISDVVKQPAFIAGIGAACWI-ILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFT 905
Query: 767 PT 768
PT
Sbjct: 906 PT 907
Score = 97.4 bits (241), Expect = 7e-20
Identities = 138/609 (22%), Positives = 230/609 (37%), Gaps = 72/609 (11%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDG---SPLDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202
Query: 303 PSNGLLHPPSASAYLTVLCMPGVI----------------RCPVRANPPLLFVSWTKDGK 346
+N + S A LTVL P + +C R + P+ V W KD
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTVRWRKDDG 261
Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 406
L ++ T + G+ +G Y+C N +G A S V + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTV--QEPPHFVV 316
Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSLI 456
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 317 KPRDQVV-ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375
Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 516
+ + + G++ C N + T + V V+ + + +G V+ D
Sbjct: 376 ITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAVD 430
Query: 517 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSVL 569
G ++ +P+ R D V ++ L G+ +Y +++ +
Sbjct: 431 GTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTCI 487
Query: 570 AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 629
A G +S + G+P P P P IP S P V + V L W P
Sbjct: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQP 544
Query: 630 PELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSF 687
Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 545 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAYG 602
Query: 688 VSDPSNTAN 696
+SDPS ++
Sbjct: 603 ISDPSQISD 611
Score = 41.2 bits (95), Expect = 0.006
Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 768 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1107 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1166
Query: 827 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873
E C P R + E E TP R A S + S
Sbjct: 1167 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1221
Query: 874 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1222 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1278
Query: 915 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1279 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1330
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 110 bits (276), Expect = 6e-24
Identities = 164/667 (24%), Positives = 244/667 (36%), Gaps = 108/667 (16%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 172 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 230
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 231 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 290
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 291 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 343
Query: 316 YLTVLCMPGVI----------------RCPVRANP-PLLFVSWTKDGKALQLDKFPG--- 355
LTV P + +C NP P +F W ++G L +
Sbjct: 344 TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQPPQS 401
Query: 356 ---WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIERPK 409
+S G L I +G Y C N G T VT V+ PP I +
Sbjct: 402 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 461
Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ----AQVDSNSSLILRPLTKEAH 465
V ++ C A G P P + W K G + Q Q++ N L +R
Sbjct: 462 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE-NGVLQIRYAKLGDT 520
Query: 466 GHWECSASNAVARVATSTNVYVLG----------TSPHVVTNVSVVALPKGANVS----- 510
G + C AS S + V T P+++ S + P+ +VS
Sbjct: 521 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNTVT 578
Query: 511 --WEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHTQY 564
W+P + G TP + + H W ++A V + GL+P+ Y
Sbjct: 579 LSWQPNLNSGA--------TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIY 630
Query: 565 QFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP--- 620
F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 631 LFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPTVL 686
Query: 621 --RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVPGL 670
+ +HW + + + GY + R G W EV PA + +++P L
Sbjct: 687 SSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIPDL 741
Query: 671 IKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFL 730
K V YE + F F S T LE PS PQ V G
Sbjct: 742 RKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG---N 790
Query: 731 GVAVLVS 737
G A+LVS
Sbjct: 791 GTAILVS 797
Score = 110 bits (274), Expect = 1e-23
Identities = 196/842 (23%), Positives = 291/842 (34%), Gaps = 158/842 (18%)
Query: 19 DGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRID 78
D R P V V GE V+ C PP G P I W + G SP D
Sbjct: 171 DFRQNPSDVMVA--VGEPAVMECQ--PPRGHPE-PTISWKKDG------------SPLDD 213
Query: 79 PDYVGRVRLQKGASLQIEGLRVEDQGWYEC----RVFFLDQHIPEDDFANGSWVHLTVNS 134
D +R G L I R D G Y C V + + E LTV
Sbjct: 214 KDERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE----------LTVLE 260
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIR 194
P F + P + L V + +C ARG P+P V W+ +L + + +++ + TL+IR
Sbjct: 261 RPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR-DDHTLKIR 318
Query: 195 RVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP 254
+V G G YTC A + G A + L V PP VV P++ V + V+ C A P
Sbjct: 319 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNP 378
Query: 255 ANLTYSWFQDNINVFHISRLQP----RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHP 310
+ W ++ S P R + G L + Q D G Y C N +
Sbjct: 379 QPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN-VAGS 436
Query: 311 PSASAYLTVLCM-----PGVIR----------------CPVRANPPLLFVSWTKDGKALQ 349
AYL V + P VIR V P+ + W KDG L
Sbjct: 437 IITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLV 495
Query: 350 LDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPK 409
+ Q G L I G Y+C G A S V P RP
Sbjct: 496 STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 555
Query: 410 EEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSN---SSLILRPLTKEAHG 466
+ LIP + P V ++ L Q ++S +S I+ + +
Sbjct: 556 DPN--------LIPSAP--SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGS 605
Query: 467 HWECSASNAVARVAT---------------STNVY----------------VLGTSPHV- 494
W+ A N + + N Y VL TS V
Sbjct: 606 SWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 665
Query: 495 --------------VTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHH- 539
+ N +V++ V W Y+Q + + Y RP +H
Sbjct: 666 HKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTVDQQSQYIQGYKILY-----RPSGANHG 719
Query: 540 --DWVSLAVPVGAAH-LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAA 596
DW+ V A + +++P L+ Y+ G SEI + T A
Sbjct: 720 ESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA-----KTLEEA 774
Query: 597 PGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEV--- 653
P PP + + G +L+ W PP +G V E + G E
Sbjct: 775 PSAPPQGVTVSKNDGNG-------TAILVSWQPPP--EDTQNGMVQEYKVWCLGNETRYH 825
Query: 654 LDPAVAGTETELLVPGLIKDVLYEFRLVAF--AGSFVSDPSNTANVSTSGLEVYPS---- 707
++ V G+ +++P L+ + Y + A AGS V + G V P
Sbjct: 826 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS 885
Query: 708 -RTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFS 766
Q+ ++ QP +G C++ + ++ SI +R +R+ P F+
Sbjct: 886 LAQQISDVVKQPAFIAGIGAACWI-ILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFT 944
Query: 767 PT 768
PT
Sbjct: 945 PT 946
Score = 97.4 bits (241), Expect = 7e-20
Identities = 138/609 (22%), Positives = 230/609 (37%), Gaps = 72/609 (11%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 67 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDG---SPLDDKDERITIR-GGKLMITYTRKSDAGKYVCV 241
Query: 303 PSNGLLHPPSASAYLTVLCMPGVI----------------RCPVRANPPLLFVSWTKDGK 346
+N + S A LTVL P + +C R + P+ V W KD
Sbjct: 242 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD-PVPTVRWRKDDG 300
Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIE 406
L ++ T + G+ +G Y+C N +G A S V + PP F+
Sbjct: 301 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTV--QEPPHFVV 355
Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSLI 456
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 356 KPRDQVV-ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 414
Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 516
+ + + G++ C N + T + V V+ + + +G V+ D
Sbjct: 415 ITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAVD 469
Query: 517 GGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSVL 569
G ++ +P+ R D V ++ L G+ +Y +++ +
Sbjct: 470 GTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTCI 526
Query: 570 AQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDP 629
A G +S + G+P P P P IP S P V + V L W P
Sbjct: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQP 583
Query: 630 PELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSF 687
Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 584 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAYG 641
Query: 688 VSDPSNTAN 696
+SDPS ++
Sbjct: 642 ISDPSQISD 650
Score = 41.2 bits (95), Expect = 0.006
Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 768 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1146 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1205
Query: 827 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873
E C P R + E E TP R A S + S
Sbjct: 1206 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1260
Query: 874 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1261 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1317
Query: 915 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1318 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1369
>gi|81158224 neuronal cell adhesion molecule isoform B precursor
[Homo sapiens]
Length = 1183
Score = 110 bits (276), Expect = 6e-24
Identities = 157/645 (24%), Positives = 247/645 (38%), Gaps = 81/645 (12%)
Query: 23 KPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFL-LPIF------IQFGLYSP 75
K ++ + ++G+S+VL C PP G PP +I W+ F LP + LY
Sbjct: 143 KEKLEPITLQSGQSLVLPCR--PPIGLPP-PIIFWMDNSFQRLPQSERVSQGLNGDLYFS 199
Query: 76 RIDP-----DYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ-------HIPEDDFA 123
+ P DY+ R ++Q + +V +D+ ++ + +F
Sbjct: 200 NVLPEDTREDYICYARFNHTQTIQ-------QKQPISVKVISVDELNDTIAANLSDTEFY 252
Query: 124 NGSWVHLTVNSPPQFQETPPAVLEVQELEP--VTLRCVARGSPLPHVTWKLRGKDLGQGQ 181
+ PP F +EL ++L C+A G P P + W L + +
Sbjct: 253 GAK---SSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNR 309
Query: 182 GQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNAS 241
+ TL+I V SG Y C A + G+ H + V P + P+N ++
Sbjct: 310 TVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPG 369
Query: 242 QDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLA-TQPDDAGCYT 300
+D +L C A P SW + + + I+ P +I DG + + Q + Y
Sbjct: 370 EDGTLICRANGNP-KPRISWLTNGVPI-EIAPDDPSRKI--DGDTIIFSNVQERSSAVYQ 425
Query: 301 CVPSN--GLLHPPSASAYLTVLCMPGVIRCP------VRANPPLLF-----------VSW 341
C SN G L A+A++ VL P I P V AN P L + W
Sbjct: 426 CNASNEYGYL---LANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW 482
Query: 342 TK--DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 399
K G AL D + GT L I + +D+ G Y+C N LG A + +K
Sbjct: 483 FKGAKGSALHEDIYVLHENGT---LEIPVAQKDSTGTYTCVARNKLGMA--KNEVHLEIK 537
Query: 400 APPAFIERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD-SNSSLI 456
P +++P+ Q G + C + D V W K R L + L+
Sbjct: 538 DPTWIVKQPEYAVVQR-GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLV 596
Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFD 516
+ ++ + G + C A+ + V+ S + V+ L K +SW PG D
Sbjct: 597 VADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDD 656
Query: 517 GGY-LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLG 575
+ +F + Y +P HH ++ A L L P+ Y F V+A N +G
Sbjct: 657 NNSPITKFIIEYEDAMHKPGLWHHQ-TEVSGTQTTAQL---KLSPYVNYSFRVMAVNSIG 712
Query: 576 SGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620
SE A E T + P PT + S P LV P
Sbjct: 713 KSLPSE----ASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKP 753
Score = 106 bits (264), Expect = 1e-22
Identities = 188/807 (23%), Positives = 295/807 (36%), Gaps = 175/807 (21%)
Query: 43 LLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVED 102
L+ A P I WL G +PI I S +ID D + +Q+ +S
Sbjct: 374 LICRANGNPKPRISWLTNG--VPIEIAPDDPSRKIDGDTIIFSNVQERSSAV-------- 423
Query: 103 QGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARG 162
Y+C ++ + F N + PP+ + +V P L C G
Sbjct: 424 ---YQCNASNEYGYLLANAFVN------VLAEPPRILTPANTLYQVIANRPALLDCAFFG 474
Query: 163 SPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQL 221
SPLP + W K + V +NGTL I ++ S+G YTC A + G A + L
Sbjct: 475 SPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL 534
Query: 222 LVLGPPVIVVPPKNSTVNASQDVSLACHAEA-YPANLTYSWFQDNINVFHISRLQPRVRI 280
+ P IV P+ + V VS C + + +LT W +DN L R
Sbjct: 535 EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDN------RELPSDERF 588
Query: 281 LVDGSLRLLA-TQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVRANPPL--- 336
VD ++A DD+G YTCV +N L SASA L+V+ +P NPP
Sbjct: 589 TVDKDHLVVADVSDDDSGTYTCV-ANTTLDSVSASAVLSVVDVP---------NPPFDLE 638
Query: 337 --------LFVSWTK-DGKALQLDKF----------PG-WSQGTEGSLIIALGNEDALGE 376
+ +SWT D + KF PG W TE S +
Sbjct: 639 LTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVS------GTQTTAQ 692
Query: 377 YSCTPY----------NSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSA 426
+PY NS+G + PS + E+Y + P +
Sbjct: 693 LKLSPYVNYSFRVMAVNSIGKSLPSEAS---------------EQYLTKASEPDKNPTAV 737
Query: 427 QG---DPPP-VVSWTKV------GRGLQGQAQVDSNSSLILRPLTKEAHGHW-ECSASNA 475
+G +P V++W + G GLQ + K+ W +N
Sbjct: 738 EGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQ----------KDGDDEWTSVVVANV 787
Query: 476 VARVATSTNVYV-------------LGTSPHVVTNVSVVALPKGA--------------N 508
+ + T +V P VV S LP A
Sbjct: 788 SKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAE 847
Query: 509 VSWEP---GFDGGYLQRFSVWY--TPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQ 563
V W+P G+LQ + ++Y T + + +R H + L H ++PGL+P +
Sbjct: 848 VHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSH 907
Query: 564 YQFSVLAQNKLGSGPFS-EIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRG 622
Y +V N G GP S + V + PEG+P+ P++ + + P L
Sbjct: 908 YTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKI----VNPTLD------------S 951
Query: 623 VLLHWDPPELVPKRLDGYVLEGRQGSQGWE---VLDPAVAGTETELLVPGLIKDVLYEFR 679
+ L WDPP L Y L+ + + E ++D + +T + L Y+F
Sbjct: 952 LTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFY 1011
Query: 680 LVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSIL 739
A S S T T+ E SR + +G +C + + +L+ +L
Sbjct: 1012 FYA-QTSAGSGSQITEEAVTTVDEAMASRQ-----VDIATQGWFIGLMCAVALLILI-LL 1064
Query: 740 AGCLLNRRRAAR---RRRKRLRQDPPL 763
C + R + + + ++ DP +
Sbjct: 1065 IVCFIRRNKGGKYPVKEKEDAHADPEI 1091
Score = 58.5 bits (140), Expect = 4e-08
Identities = 94/428 (21%), Positives = 157/428 (36%), Gaps = 66/428 (15%)
Query: 128 VHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ 187
V L + PP + P + E + ++C A+G P P +W G + +
Sbjct: 32 VPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTM 91
Query: 188 ---NGTLRIRRVERGSS----GVYTCQASSTEGSAT------------------------ 216
GTL I + G + GVY C A + G+A
Sbjct: 92 KPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITL 151
Query: 217 HATQLLVL--GPPVIVVPP-----KNS--TVNASQDVSLACHAEAYPAN----------L 257
+ Q LVL PP+ + PP NS + S+ VS + + Y +N +
Sbjct: 152 QSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYI 211
Query: 258 TYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV-----PSNGLLHPPS 312
Y+ F + + +V I VD +A D Y P L +
Sbjct: 212 CYARFNHTQTIQQKQPISVKV-ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGN 270
Query: 313 ASAYLTVLCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNED 372
AS + + C + P + W K+ L ++ + E +L I +E
Sbjct: 271 ASNKEELRGNVLSLEC-IAEGLPTPIIYWAKEDGMLPKNRTV--YKNFEKTLQIIHVSEA 327
Query: 373 ALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPP 432
G Y C N+LG + RV KA P +I P + G + + C A G+P P
Sbjct: 328 DSGNYQCIAKNALGAIHHTISVRV--KAAPYWITAP-QNLVLSPGEDGTLICRANGNPKP 384
Query: 433 VVSWTKVGRGLQ----GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVL 488
+SW G ++ ++ ++I + + + ++C+ASN + + V VL
Sbjct: 385 RISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL 444
Query: 489 GTSPHVVT 496
P ++T
Sbjct: 445 AEPPRILT 452
>gi|81158226 neuronal cell adhesion molecule isoform A precursor
[Homo sapiens]
Length = 1304
Score = 110 bits (275), Expect = 8e-24
Identities = 159/655 (24%), Positives = 250/655 (38%), Gaps = 91/655 (13%)
Query: 23 KPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFL-LPIF------IQFGLYSP 75
K ++ + ++G+S+VL C PP G PP +I W+ F LP + LY
Sbjct: 149 KEKLEPITLQSGQSLVLPCR--PPIGLPP-PIIFWMDNSFQRLPQSERVSQGLNGDLYFS 205
Query: 76 RIDP-----DYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ-------HIPEDDFA 123
+ P DY+ R ++Q + +V +D+ ++ + +F
Sbjct: 206 NVLPEDTREDYICYARFNHTQTIQ-------QKQPISVKVISVDELNDTIAANLSDTEFY 258
Query: 124 NGSWVHLTVNSPPQFQETPPAVLEVQELEP--VTLRCVARGSPLPHVTWKLRGKDLGQGQ 181
+ PP F +EL ++L C+A G P P + W L + +
Sbjct: 259 GAK---SSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNR 315
Query: 182 GQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNAS 241
+ TL+I V SG Y C A + G+ H + V P + P+N ++
Sbjct: 316 TVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPG 375
Query: 242 QDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLA-TQPDDAGCYT 300
+D +L C A P SW + + + I+ P +I DG + + Q + Y
Sbjct: 376 EDGTLICRANGNP-KPRISWLTNGVPI-EIAPDDPSRKI--DGDTIIFSNVQERSSAVYQ 431
Query: 301 CVPSN--GLLHPPSASAYLTVLCMPGVIRCP------VRANPPLLF-----------VSW 341
C SN G L A+A++ VL P I P V AN P L + W
Sbjct: 432 CNASNEYGYL---LANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW 488
Query: 342 TK--DGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLK 399
K G AL D + GT L I + +D+ G Y+C N LG A + +K
Sbjct: 489 FKGAKGSALHEDIYVLHENGT---LEIPVAQKDSTGTYTCVARNKLGMA--KNEVHLEIK 543
Query: 400 APPAFIERPKEEYFQEVGRELLIPCSAQGDP--PPVVSWTKVGRGLQGQAQVD-SNSSLI 456
P +++P+ Q G + C + D V W K R L + L+
Sbjct: 544 DPTWIVKQPEYAVVQR-GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLV 602
Query: 457 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVV----------ALPKG 506
+ ++ + G + C A+ + V+ S + V+ +P V L K
Sbjct: 603 VADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKS 662
Query: 507 ANVSWEPGFDGGY-LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQ 565
+SW PG D + +F + Y +P HH ++ A L L P+ Y
Sbjct: 663 VQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQ-TEVSGTQTTAQL---KLSPYVNYS 718
Query: 566 FSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620
F V+A N +G SE A E T + P PT + S P LV P
Sbjct: 719 FRVMAVNSIGKSLPSE----ASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKP 769
Score = 105 bits (262), Expect = 3e-22
Identities = 185/770 (24%), Positives = 279/770 (36%), Gaps = 168/770 (21%)
Query: 43 LLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVED 102
L+ A P I WL G +PI I S +ID D + +Q+ +S
Sbjct: 380 LICRANGNPKPRISWLTNG--VPIEIAPDDPSRKIDGDTIIFSNVQERSSAV-------- 429
Query: 103 QGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARG 162
Y+C ++ + F N + PP+ + +V P L C G
Sbjct: 430 ---YQCNASNEYGYLLANAFVN------VLAEPPRILTPANTLYQVIANRPALLDCAFFG 480
Query: 163 SPLPHVTWKLRGKDLGQGQG-QVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQL 221
SPLP + W K + V +NGTL I ++ S+G YTC A + G A + L
Sbjct: 481 SPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL 540
Query: 222 LVLGPPVIVVPPKNSTVNASQDVSLACHAEA-YPANLTYSWFQDNINVFHISRLQPRVRI 280
+ P IV P+ + V VS C + + +LT W +DN L R
Sbjct: 541 EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDN------RELPSDERF 594
Query: 281 LVDGSLRLLA-TQPDDAGCYTCVPSNGLLHPPSASAYLTVLCMPGVIRCPVR--ANPPL- 336
VD ++A DD+G YTCV +N L SASA L+V+ P PV NPP
Sbjct: 595 TVDKDHLVVADVSDDDSGTYTCV-ANTTLDSVSASAVLSVVA-PTPTPAPVYDVPNPPFD 652
Query: 337 ----------LFVSWTK-DGKALQLDKF----------PG-WSQGTEGSLIIALGNEDAL 374
+ +SWT D + KF PG W TE S
Sbjct: 653 LELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVS------GTQTT 706
Query: 375 GEYSCTPY----------NSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC 424
+ +PY NS+G + PS + E+Y + P
Sbjct: 707 AQLKLSPYVNYSFRVMAVNSIGKSLPSEAS---------------EQYLTKASEPDKNPT 751
Query: 425 SAQG---DPPP-VVSWTKV------GRGLQGQAQVDSNSSLILRPLTKEAHGHW-ECSAS 473
+ +G +P V++W + G GLQ + K+ W +
Sbjct: 752 AVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQ----------KDGDDEWTSVVVA 801
Query: 474 NAVARVATSTNVYV-------------LGTSPHVVTNVSVVALPKGA------------- 507
N + + T +V P VV S LP A
Sbjct: 802 NVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTL 861
Query: 508 -NVSWEP---GFDGGYLQRFSVWY--TPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPH 561
V W+P G+LQ + ++Y T + + +R H + L H ++PGL+P
Sbjct: 862 AEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPF 921
Query: 562 TQYQFSVLAQNKLGSGPFS-EIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 620
+ Y +V N G GP S + V + PEG+P+ P++ + + P L
Sbjct: 922 SHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKI----VNPTLD----------- 966
Query: 621 RGVLLHWDPPELVPKRLDGYVLEGRQGSQGWE---VLDPAVAGTETELLVPGLIKDVLYE 677
+ L WDPP L Y L+ + + E ++D + +T + L Y+
Sbjct: 967 -SLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYK 1025
Query: 678 FRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGV 727
F A +A + E + G+LP V AG V V
Sbjct: 1026 FYFYA---------QTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAV 1066
Score = 57.4 bits (137), Expect = 8e-08
Identities = 92/421 (21%), Positives = 154/421 (36%), Gaps = 66/421 (15%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQ---NGTL 191
PP + P + E + ++C A+G P P +W G + + GTL
Sbjct: 45 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 104
Query: 192 RIRRVERGSS----GVYTCQASSTEGSAT------------------------HATQLLV 223
I + G + GVY C A + G+A + Q LV
Sbjct: 105 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLV 164
Query: 224 L--GPPVIVVPP-----KNS--TVNASQDVSLACHAEAYPAN----------LTYSWFQD 264
L PP+ + PP NS + S+ VS + + Y +N + Y+ F
Sbjct: 165 LPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNH 224
Query: 265 NINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV-----PSNGLLHPPSASAYLTV 319
+ + +V I VD +A D Y P L +AS +
Sbjct: 225 TQTIQQKQPISVKV-ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEEL 283
Query: 320 LCMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSC 379
+ C + P + W K+ L ++ + E +L I +E G Y C
Sbjct: 284 RGNVLSLEC-IAEGLPTPIIYWAKEDGMLPKNRTV--YKNFEKTLQIIHVSEADSGNYQC 340
Query: 380 TPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKV 439
N+LG + RV KA P +I P + G + + C A G+P P +SW
Sbjct: 341 IAKNALGAIHHTISVRV--KAAPYWITAP-QNLVLSPGEDGTLICRANGNPKPRISWLTN 397
Query: 440 GRGLQ----GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVV 495
G ++ ++ ++I + + + ++C+ASN + + V VL P ++
Sbjct: 398 GVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRIL 457
Query: 496 T 496
T
Sbjct: 458 T 458
Score = 40.4 bits (93), Expect = 0.010
Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 18/103 (17%)
Query: 398 LKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLIL 457
L PP ++ ++Y + ++I C A+G PPP SWT+ G +D + + +
Sbjct: 42 LVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGT----HFDIDKDPLVTM 97
Query: 458 RPLT-------------KEAHGHWECSASNAVARVATSTNVYV 487
+P T + G ++C+A N A S N+ V
Sbjct: 98 KPGTGTLIINIMSEGKAETYEGVYQCTARNE-RGAAVSNNIVV 139
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 108 bits (270), Expect = 3e-23
Identities = 163/669 (24%), Positives = 241/669 (36%), Gaps = 109/669 (16%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304
Query: 316 YLTV-------------------LCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 355
LTV L +C NP P +F W ++G L +
Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362
Query: 356 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 406
+S G L I +G Y C N G T VT V+ PP I
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422
Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 463
+ V ++ C A G P P + W K G + Q + N L +R
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 464 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 509
G + C AS S + V T P+++ S + P+ +V
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540
Query: 510 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 562
SW+P + G TP + + H W ++A V + GL+P+
Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592
Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 620
Y F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648
Query: 621 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 668
+ +HW + + + GY + R G W EV PA + +++P
Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703
Query: 669 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 728
L K V YE + F F S T LE PS PQ V G
Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753
Query: 729 FLGVAVLVS 737
G A+LVS
Sbjct: 754 -NGTAILVS 761
Score = 97.1 bits (240), Expect = 9e-20
Identities = 138/610 (22%), Positives = 231/610 (37%), Gaps = 71/610 (11%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202
Query: 303 PSNGLLHPPSASAYLTVLCMPGVIR----------------CPVRANPPLLFVSWTKDGK 346
+N + S A LTVL P ++ C R +P + V W KD
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261
Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 405
L ++ T + G+ +G Y+C N +G A S V + + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 455
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 456 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 515
+ + + G++ C N + T + V V+ + + +G V+
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432
Query: 516 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 568
DG ++ +P+ R D V ++ L G+ +Y +++
Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489
Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628
+A G +S + G+P P P P IP S P V + V L W
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546
Query: 629 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 686
P Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604
Query: 687 FVSDPSNTAN 696
+SDPS ++
Sbjct: 605 GISDPSQISD 614
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G +V C+ A P I W R G +F Y P P R + + L
Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I ++ D G+Y C+ + I + + V + PP P V
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212
L CVA GSP+P + W+ G + ++ Q++NG L+IR + G +G YTC AS+
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267
G AT + + V V V PP+ + N N +T SW Q N+N
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550
Score = 41.2 bits (95), Expect = 0.006
Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 768 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1046 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1105
Query: 827 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873
E C P R + E E TP R A S + S
Sbjct: 1106 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1160
Query: 874 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1161 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1217
Query: 915 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1218 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1269
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 108 bits (270), Expect = 3e-23
Identities = 163/669 (24%), Positives = 241/669 (36%), Gaps = 109/669 (16%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304
Query: 316 YLTV-------------------LCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 355
LTV L +C NP P +F W ++G L +
Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362
Query: 356 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 406
+S G L I +G Y C N G T VT V+ PP I
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422
Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 463
+ V ++ C A G P P + W K G + Q + N L +R
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 464 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 509
G + C AS S + V T P+++ S + P+ +V
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540
Query: 510 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 562
SW+P + G TP + + H W ++A V + GL+P+
Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592
Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 620
Y F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648
Query: 621 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 668
+ +HW + + + GY + R G W EV PA + +++P
Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703
Query: 669 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 728
L K V YE + F F S T LE PS PQ V G
Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753
Query: 729 FLGVAVLVS 737
G A+LVS
Sbjct: 754 -NGTAILVS 761
Score = 97.1 bits (240), Expect = 9e-20
Identities = 138/610 (22%), Positives = 231/610 (37%), Gaps = 71/610 (11%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202
Query: 303 PSNGLLHPPSASAYLTVLCMPGVIR----------------CPVRANPPLLFVSWTKDGK 346
+N + S A LTVL P ++ C R +P + V W KD
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261
Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 405
L ++ T + G+ +G Y+C N +G A S V + + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 455
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 456 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 515
+ + + G++ C N + T + V V+ + + +G V+
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432
Query: 516 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 568
DG ++ +P+ R D V ++ L G+ +Y +++
Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489
Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628
+A G +S + G+P P P P IP S P V + V L W
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546
Query: 629 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 686
P Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604
Query: 687 FVSDPSNTAN 696
+SDPS ++
Sbjct: 605 GISDPSQISD 614
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G +V C+ A P I W R G +F Y P P R + + L
Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I ++ D G+Y C+ + I + + V + PP P V
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212
L CVA GSP+P + W+ G + ++ Q++NG L+IR + G +G YTC AS+
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267
G AT + + V V V PP+ + N N +T SW Q N+N
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550
Score = 41.2 bits (95), Expect = 0.006
Identities = 64/238 (26%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 768 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1101 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1160
Query: 827 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873
E C P R + E E TP R A S + S
Sbjct: 1161 VDESYDQEMPCPVPPARMYL-----QQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1215
Query: 874 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1216 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1272
Query: 915 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1273 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1324
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 108 bits (270), Expect = 3e-23
Identities = 163/669 (24%), Positives = 241/669 (36%), Gaps = 109/669 (16%)
Query: 138 FQETPPAVLEVQELEPVTLRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRV 196
F++ P V+ V EP + C RG P P ++WK G L ++ ++ G L I
Sbjct: 133 FRQNPSDVM-VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191
Query: 197 ERGSSGVYTCQASSTEGSA-THATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
+ +G Y C ++ G + +L VL P V P N V C A P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
T W +D+ + + R I D +L++ D G YTCV N ++ ASA
Sbjct: 252 P-TVRWRKDDGEL-----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN-MVGKAEASA 304
Query: 316 YLTV-------------------LCMPGVIRCPVRANP-PLLFVSWTKDGKALQLDKFPG 355
LTV L +C NP P +F W ++G L +
Sbjct: 305 TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF--WRREGSQNLLFSYQP 362
Query: 356 ------WSQGTEGSLIIALGNEDALGEYSCTPYNSLG---TAGPSPVTRVLLKAPPAFIE 406
+S G L I +G Y C N G T VT V+ PP I
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422
Query: 407 RPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---AQVDSNSSLILRPLTKE 463
+ V ++ C A G P P + W K G + Q + N L +R
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 464 AHGHWECSASNAVARVATSTNVYV----------LGTSPHVVTNVSVVALPKGANV---- 509
G + C AS S + V T P+++ S + P+ +V
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP--SAPSKPEVTDVSRNT 540
Query: 510 ---SWEPGFDGGYLQRFSVWYTPLAKRPDRMHH----DWVSLAVPVGAAHLLVPGLQPHT 562
SW+P + G TP + + H W ++A V + GL+P+
Sbjct: 541 VTLSWQPNLNSG--------ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592
Query: 563 QYQFSVLAQNKLGSGPFSEIVLSAP-EGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP- 620
Y F V A N G S+I S P + P + G+ ++ L ++ + P
Sbjct: 593 IYLFLVRAANAYGISDPSQI--SDPVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPT 648
Query: 621 ----RGVLLHWDPPELVPKRLDGYVLEGR-----QGSQGW---EVLDPAVAGTETELLVP 668
+ +HW + + + GY + R G W EV PA + +++P
Sbjct: 649 VLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPA----KNSVVIP 703
Query: 669 GLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVC 728
L K V YE + F F S T LE PS PQ V G
Sbjct: 704 DLRKGVNYEIKARPFFNEFQGADSEIKFAKT--LEEAPSAP------PQGVTVSKNDG-- 753
Query: 729 FLGVAVLVS 737
G A+LVS
Sbjct: 754 -NGTAILVS 761
Score = 97.1 bits (240), Expect = 9e-20
Identities = 138/610 (22%), Positives = 231/610 (37%), Gaps = 71/610 (11%)
Query: 135 PPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQG-----QVQVQNG 189
PP+ E P ++ V + EP TL C A G P P + W G+ + + ++ + +G
Sbjct: 28 PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 190 TLRIRRVERG-----SSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVPPKNSTVNASQ 242
+L R+ G GVY C A + G A +A+ + + P + V +
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCV 302
+ C T SW +D + R+ I G L + T+ DAG Y CV
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIR-GGKLMITYTRKSDAGKYVCV 202
Query: 303 PSNGLLHPPSASAYLTVLCMPGVIR----------------CPVRANPPLLFVSWTKDGK 346
+N + S A LTVL P ++ C R +P + V W KD
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVRWRKDDG 261
Query: 347 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKA-PPAFI 405
L ++ T + G+ +G Y+C N +G A S V + + PP F+
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGD---MGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 406 ERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGR----------GLQGQAQVDSNSSL 455
+P+++ +GR + C A G+P P + W + G + V L
Sbjct: 319 VKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 456 ILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGF 515
+ + + G++ C N + T + V V+ + + +G V+
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEV----TDVIADRPPPVIRQGP-VNQTVAV 432
Query: 516 DGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQY-------QFSV 568
DG ++ +P+ R D V ++ L G+ +Y +++
Sbjct: 433 DGTFVLSCVATGSPVPTILWR--KDGVLVSTQDSRIKQLENGVL-QIRYAKLGDTGRYTC 489
Query: 569 LAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWD 628
+A G +S + G+P P P P IP S P V + V L W
Sbjct: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRP-TDPNLIPSAPSKPE--VTDVSRNTVTLSWQ 546
Query: 629 PPELVPKRLDGYVLEGRQGSQG--WEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGS 686
P Y++E + G W+ + V TET + GL + +Y F + A
Sbjct: 547 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAANAY 604
Query: 687 FVSDPSNTAN 696
+SDPS ++
Sbjct: 605 GISDPSQISD 614
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 16/236 (6%)
Query: 34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASL 93
G +V C+ A P I W R G +F Y P P R + + L
Sbjct: 329 GRTVTFQCE----ATGNPQPAIFWRREGSQNLLFS----YQP---PQSSSRFSVSQTGDL 377
Query: 94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEP 153
I ++ D G+Y C+ + I + + V + PP P V
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQTVAVDGT 435
Query: 154 VTLRCVARGSPLPHVTWKLRGKDLGQGQGQV-QVQNGTLRIRRVERGSSGVYTCQASSTE 212
L CVA GSP+P + W+ G + ++ Q++NG L+IR + G +G YTC AS+
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 213 GSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYSWFQDNIN 267
G AT + + V V V PP+ + N N +T SW Q N+N
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW-QPNLN 550
Score = 42.0 bits (97), Expect = 0.003
Identities = 65/238 (27%), Positives = 80/238 (33%), Gaps = 47/238 (19%)
Query: 768 TGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPL- 826
TG S S GS + S K +P + + W D P HP P S+ +
Sbjct: 1057 TGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNIS 1116
Query: 827 -------EPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSS------ 873
E C P R T E E TP R A S + S
Sbjct: 1117 VDESYDQEMPCPVPPAR-----TYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1171
Query: 874 -----SPSGAPQPL---CIEDI-----------SPVAPPPAAPPSPLPGPGPLLQYLSLP 914
SP QP+ C E+ PV+PPP PP P+ P Y+S P
Sbjct: 1172 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP--PPRPI-SPPHTYGYISGP 1228
Query: 915 FFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGA 972
+M D D P EE M TRR LR E P S L +V G+
Sbjct: 1229 LVSDM--DTDAPEEEEDEADMEVAKMQTRRL----LLRGLEQTPASSVGDLESSVTGS 1280
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,029,305
Number of Sequences: 37866
Number of extensions: 3727163
Number of successful extensions: 34998
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 246
Number of HSP's successfully gapped in prelim test: 1244
Number of HSP's that attempted gapping in prelim test: 19898
Number of HSP's gapped (non-prelim): 10936
length of query: 1163
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1050
effective length of database: 13,968,660
effective search space: 14667093000
effective search space used: 14667093000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.