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Search of human proteins with 105990535
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|105990535 coagulation factor V precursor [Homo sapiens]
(2224 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|105990535 coagulation factor V precursor [Homo sapiens] 4556 0.0
gi|4503647 coagulation factor VIII isoform a precursor [Homo sap... 532 e-150
gi|148886707 hephaestin-like 1 [Homo sapiens] 440 e-123
gi|4557485 ceruloplasmin precursor [Homo sapiens] 399 e-110
gi|195963313 hephaestin isoform a [Homo sapiens] 397 e-110
gi|195947365 hephaestin isoform c [Homo sapiens] 397 e-110
gi|7662254 hephaestin isoform b [Homo sapiens] 367 e-101
gi|31317224 EGF-like repeats and discoidin I-like domains-contai... 266 2e-70
gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Ho... 253 1e-66
gi|10518506 coagulation factor VIII isoform b precursor [Homo sa... 198 6e-50
gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Ho... 194 6e-49
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 151 6e-36
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 151 6e-36
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 151 6e-36
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 151 6e-36
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 151 6e-36
gi|66864913 neuropilin 1 isoform c [Homo sapiens] 138 7e-32
gi|66912178 neuropilin 1 isoform b [Homo sapiens] 138 7e-32
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 138 7e-32
gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo sa... 136 2e-31
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens] 124 1e-27
gi|27735143 discoidin, CUB and LCCL domain containing 1 [Homo sa... 123 2e-27
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 111 9e-24
gi|10835083 X-linked juvenile retinoschisis protein precursor [H... 110 2e-23
gi|223005864 carboxypeptidase X (M14 family), member 2 [Homo sap... 99 6e-20
gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo... 93 3e-18
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi... 92 6e-18
gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sap... 86 3e-16
gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sap... 86 3e-16
gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2... 86 4e-16
>gi|105990535 coagulation factor V precursor [Homo sapiens]
Length = 2224
Score = 4556 bits (11816), Expect = 0.0
Identities = 2224/2224 (100%), Positives = 2224/2224 (100%)
Query: 1 MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTS 60
MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTS
Sbjct: 1 MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTS 60
Query: 61 FKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYS 120
FKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYS
Sbjct: 61 FKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYS 120
Query: 121 KLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIE 180
KLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIE
Sbjct: 121 KLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIE 180
Query: 181 DFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSSLMYTVNGYVNG 240
DFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSSLMYTVNGYVNG
Sbjct: 181 DFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSSLMYTVNGYVNG 240
Query: 241 TMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTV 300
TMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTV
Sbjct: 241 TMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTV 300
Query: 301 GPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVI 360
GPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVI
Sbjct: 301 GPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVI 360
Query: 361 WDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMKEDGILG 420
WDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMKEDGILG
Sbjct: 361 WDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMKEDGILG 420
Query: 421 PIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGET 480
PIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGET
Sbjct: 421 PIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGET 480
Query: 481 YTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAA 540
YTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAA
Sbjct: 481 YTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAA 540
Query: 541 DIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTL 600
DIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTL
Sbjct: 541 DIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTL 600
Query: 601 GFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGT 660
GFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGT
Sbjct: 601 GFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGT 660
Query: 661 WMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEES 720
WMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEES
Sbjct: 661 WMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEES 720
Query: 721 DADYDYQNRLAAALGIRSFRNSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSP 780
DADYDYQNRLAAALGIRSFRNSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSP
Sbjct: 721 DADYDYQNRLAAALGIRSFRNSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSP 780
Query: 781 SNISKFTVNNLAEPQKAPSHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPL 840
SNISKFTVNNLAEPQKAPSHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPL
Sbjct: 781 SNISKFTVNNLAEPQKAPSHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPL 840
Query: 841 QPDVTGIRLLSLGAGEFKSQEHAKHKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGS 900
QPDVTGIRLLSLGAGEFKSQEHAKHKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGS
Sbjct: 841 QPDVTGIRLLSLGAGEFKSQEHAKHKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGS 900
Query: 901 PSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQ 960
PSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQ
Sbjct: 901 PSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQ 960
Query: 961 DTDEDTAVNNWLISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRL 1020
DTDEDTAVNNWLISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRL
Sbjct: 961 DTDEDTAVNNWLISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRL 1020
Query: 1021 KKSQFLIKTRKKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPT 1080
KKSQFLIKTRKKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPT
Sbjct: 1021 KKSQFLIKTRKKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPT 1080
Query: 1081 DLNQTLPSMDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHS 1140
DLNQTLPSMDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHS
Sbjct: 1081 DLNQTLPSMDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHS 1140
Query: 1141 TSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELS 1200
TSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELS
Sbjct: 1141 TSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELS 1200
Query: 1201 QTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSP 1260
QTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSP
Sbjct: 1201 QTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSP 1260
Query: 1261 ELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMP 1320
ELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMP
Sbjct: 1261 ELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMP 1320
Query: 1321 ISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPELS 1380
ISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPELS
Sbjct: 1321 ISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPELS 1380
Query: 1381 QTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQVTLSP 1440
QTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQVTLSP
Sbjct: 1381 QTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQVTLSP 1440
Query: 1441 DISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPSSPTLND 1500
DISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPSSPTLND
Sbjct: 1441 DISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPSSPTLND 1500
Query: 1501 TFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKTDVRTNINS 1560
TFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKTDVRTNINS
Sbjct: 1501 TFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKTDVRTNINS 1560
Query: 1561 SRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIPEDTTYKKVVF 1620
SRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIPEDTTYKKVVF
Sbjct: 1561 SRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIPEDTTYKKVVF 1620
Query: 1621 RKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKS 1680
RKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKS
Sbjct: 1621 RKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKS 1680
Query: 1681 SEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDI 1740
SEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDI
Sbjct: 1681 SEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDI 1740
Query: 1741 HSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMK 1800
HSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMK
Sbjct: 1741 HSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMK 1800
Query: 1801 KSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLG 1860
KSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLG
Sbjct: 1801 KSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLG 1860
Query: 1861 VWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISD 1920
VWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISD
Sbjct: 1861 VWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISD 1920
Query: 1921 SQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQG 1980
SQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQG
Sbjct: 1921 SQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQG 1980
Query: 1981 AKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARY 2040
AKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARY
Sbjct: 1981 AKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARY 2040
Query: 2041 IRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFR 2100
IRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFR
Sbjct: 2041 IRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFR 2100
Query: 2101 ARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQ 2160
ARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQ
Sbjct: 2101 ARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQ 2160
Query: 2161 GVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFG 2220
GVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFG
Sbjct: 2161 GVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFG 2220
Query: 2221 CDIY 2224
CDIY
Sbjct: 2221 CDIY 2224
>gi|4503647 coagulation factor VIII isoform a precursor [Homo sapiens]
Length = 2351
Score = 532 bits (1371), Expect = e-150
Identities = 288/699 (41%), Positives = 416/699 (59%), Gaps = 38/699 (5%)
Query: 1535 EDDYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDY- 1593
+ D EIDY DD +++ D D + RS R+Y+IAA E WDY
Sbjct: 1675 QSDQEEIDY---DDTISVEMKKEDFDIYDEDENQS--PRSFQKKTRHYFIAAVERLWDYG 1729
Query: 1594 ---SEFVQRETDIEDSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRA 1650
S V R S +P+ +KKVVF+++ D +FT+ RGE EHLG+LGP IRA
Sbjct: 1730 MSSSPHVLRNR--AQSGSVPQ---FKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRA 1784
Query: 1651 EVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVW 1710
EV+D I V F+N ASRPYS ++ +SYE ED N V+PN + TY W
Sbjct: 1785 EVEDNIMVTFRNQASRPYSFYSSLISYE--------EDQRQGAEPRKNFVKPNETKTYFW 1836
Query: 1711 HATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFV 1770
P C+AWAY+S V+ EKD+HSGLIGPLL+C L+ + ++EF
Sbjct: 1837 KVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFA 1896
Query: 1771 LLFMTFDEKKSWYYEKKSRSSWR------LTSSEMKKSHEFHAINGMIY-SLPGLKMYEQ 1823
L F FDE KSWY+ + + R + K+++ FHAING I +LPGL M +
Sbjct: 1897 LFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQD 1956
Query: 1824 EWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWL 1883
+ +R +LL++G +++IH +HF G +++++ ++ L PG F+T+EM SK G W
Sbjct: 1957 QRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWR 2016
Query: 1884 LNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGG 1943
+ +GE+ AGM T FL+ C+ P+G+++G I D QI AS G W P+LARL+ G
Sbjct: 2017 VECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSG 2076
Query: 1944 SYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQIN 2003
S NAWS ++ + WI+VD+ +II GI+TQGA+ S Y ++F + YS +
Sbjct: 2077 SINAWSTKEPFS------WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKK 2130
Query: 2004 WQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEV 2063
WQ ++GNST +M F GN D+S IK N F+PPI+ARYIR+ PT R TLR+EL GC++
Sbjct: 2131 WQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDL 2190
Query: 2064 NGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWL 2123
N CS PLGME+ I + QITASS+ + + W P +ARL+ QGR NAW+ + NN K+WL
Sbjct: 2191 NSCSMPLGMESKAISDAQITASSYFTNMFAT-WSPSKARLHLQGRSNAWRPQVNNPKEWL 2249
Query: 2124 EIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN 2183
++D K K+T + TQG KSL + MYVK + I S+ G +W + + K+F+GN +
Sbjct: 2250 QVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV--KVFQGNQD 2307
Query: 2184 TKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCD 2222
+ V N +PP+++R++R+ P++W IALR+E+ GC+
Sbjct: 2308 SFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE 2346
Score = 499 bits (1284), Expect = e-140
Identities = 278/730 (38%), Positives = 404/730 (55%), Gaps = 75/730 (10%)
Query: 32 RQFYVAAQGISWSYRPE---------------PTNSSLNLSVTSFKKIVYREYEPY-FKK 75
R++Y+ A +SW Y P + N SV +KK ++ E+ + F
Sbjct: 22 RRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVV-YKKTLFVEFTDHLFNI 80
Query: 76 EKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPA 135
KP+ GLLGPT+ AEV D + + KN A P+S+H G+ Y K SEGA Y D T
Sbjct: 81 AKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQR 140
Query: 136 EKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKK 195
EK DD V PG +TY W + +++GP DP CLT+ Y SH +L++D NSGLIG LL+C++
Sbjct: 141 EKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCRE 200
Query: 196 GTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSS----------------LMYTVNGYVN 239
G+L + TQ + +LLFAVFDE KSW + M+TVNGYVN
Sbjct: 201 GSLAKEKTQTLH--KFILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGYVN 258
Query: 240 GTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMT 299
++P + C + WH++GM + PE+ SI G +H+ +++ + T TA
Sbjct: 259 RSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTL 318
Query: 300 VGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQ---------------- 343
+ G++++ H GM+AY+ + +CP++ + K E
Sbjct: 319 LMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDYDDDLTDSEMDVVR 378
Query: 344 ----------------RRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQI 387
++H K W ++IAAEE WDYAP++ A D+ Y+SQ+L+N +I
Sbjct: 379 FDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRI 438
Query: 388 GKHYKKVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYP 447
G+ YKKV + Y DE+F T E GILGP++ +V DTL I+FKN ASRPY+IYP
Sbjct: 439 GRKYKKVRFMAYTDETFK--TREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYP 496
Query: 448 HGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYS 507
HG+T + G + + PGE + YKW + D PT++D +CLTR Y S
Sbjct: 497 HGIT--DVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSS 554
Query: 508 DVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFC 567
V++ RD+ASGLIG LLIC S+D+RG Q +D +F+VFDEN+SWYL +NI +F
Sbjct: 555 FVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFL 614
Query: 568 ENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFT 627
NP V+ +DP+F SNIM +INGYV +S+ L C + W+ S+G Q + L++ F+
Sbjct: 615 PNPAGVQLEDPEFQASNIMHSINGYVFDSL-QLSVCLHEVAYWYILSIGAQTDFLSVFFS 673
Query: 628 GHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKC--- 684
G++F + +EDTLTLFP GE+V ++M+N G W+L NS R++ + + C
Sbjct: 674 GYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKN 733
Query: 685 IPDDDEDSYE 694
D EDSYE
Sbjct: 734 TGDYYEDSYE 743
Score = 199 bits (506), Expect = 3e-50
Identities = 114/327 (34%), Positives = 179/327 (54%), Gaps = 17/327 (5%)
Query: 1580 RNYYIAAEEISWDY--SEFVQRETDIEDSDDIPED------TTYKKVVFRKYLDSTFTKR 1631
R YY+ A E+SWDY S+ + D +P+ YKK +F ++ D F
Sbjct: 22 RRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLFNIA 81
Query: 1632 DPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSP 1691
PR + +G+LGP I+AEV D + + KN+AS P SLHA G+SY K+SEG Y+D +
Sbjct: 82 KPRPPW---MGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTS 138
Query: 1692 EWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLIC 1751
+ KED+ V P S+TYVW + +GP + C ++Y S V+ KD++SGLIG LL+C
Sbjct: 139 QREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVC 198
Query: 1752 QKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMKKSHEFHAINGM 1811
++G L K+ + +F+LLF FDE KSW+ E K+ ++ + + H +NG
Sbjct: 199 REGSLAKEKT--QTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGY 256
Query: 1812 I-YSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFK 1870
+ SLPGL ++ V H++ +G + ++H + G T L ++Q L + P+ +F
Sbjct: 257 VNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPI---TFL 313
Query: 1871 TLEMKASKPGWWLLNTEVGENQRAGMQ 1897
T + G +LL + +Q GM+
Sbjct: 314 TAQTLLMDLGQFLLFCHISSHQHDGME 340
Score = 188 bits (478), Expect = 4e-47
Identities = 108/320 (33%), Positives = 166/320 (51%), Gaps = 23/320 (7%)
Query: 348 KRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGK--HYKKVMYTQYEDESFT 405
K YFIAA E +WDY S H+ Q G +KKV++ ++ D SFT
Sbjct: 1713 KTRHYFIAAVERLWDYG---------MSSSPHVLRNRAQSGSVPQFKKVVFQEFTDGSFT 1763
Query: 406 KHTVNPNMKED-GILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFT 464
+ + E G+LGP IRA+V D + + F+N ASRPYS Y ++ YE++
Sbjct: 1764 QPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLIS---YEEDQRQGAE 1820
Query: 465 SGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLL 524
+N V+P ET TY W + PT+++ C Y+SDVD+ +D+ SGLIG LL
Sbjct: 1821 PRKN-----FVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLL 1875
Query: 525 ICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESN 584
+C + +L+ ++ E F +FDE KSWY +N+ + C P ++ +DP F E+
Sbjct: 1876 VCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENY 1935
Query: 585 IMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTL--- 641
INGY+ +++ L D ++W+ S+G+ I +IHF+GH F K+ E +
Sbjct: 1936 RFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALY 1995
Query: 642 TLFPMRGESVTVTMDNVGTW 661
L+P E+V + G W
Sbjct: 1996 NLYPGVFETVEMLPSKAGIW 2015
Score = 162 bits (410), Expect = 3e-39
Identities = 118/384 (30%), Positives = 170/384 (44%), Gaps = 38/384 (9%)
Query: 1529 EEVQSSEDDY--AEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAA 1586
EE + +DD +E+D V +DD P I + + +YIAA
Sbjct: 360 EEAEDYDDDLTDSEMDVVRFDD------------DNSPSFIQIRSVAKKHPKTWVHYIAA 407
Query: 1587 EEISWDYSEFVQRETDIEDSDDIPED------TTYKKVVFRKYLDSTFTKRDPRGEYEEH 1640
EE WDY+ V D + YKKV F Y D TF R+ +
Sbjct: 408 EEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREA---IQHE 464
Query: 1641 LGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFK--EDN 1698
GILGP++ EV D + + FKN ASRPY+++ HG++ + Y P+ K +D
Sbjct: 465 SGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRP----LYSRRLPKGVKHLKDF 520
Query: 1699 AVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHK 1758
+ P + Y W T GP C Y S VN E+D+ SGLIGPLLIC K + +
Sbjct: 521 PILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQ 580
Query: 1759 DSNMPMDMREFVLLFMTFDEKKSWYYEKK------SRSSWRLTSSEMKKSHEFHAINGMI 1812
N M + V+LF FDE +SWY + + + +L E + S+ H+ING +
Sbjct: 581 RGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYV 640
Query: 1813 YSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTL 1872
+ L + E ++L+IG D V F G T +K L P S +T+
Sbjct: 641 FDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTF---KHKMVYEDTLTLFPFSGETV 697
Query: 1873 EMKASKPGWWLLNTEVGENQRAGM 1896
M PG W+L + + GM
Sbjct: 698 FMSMENPGLWILGCHNSDFRNRGM 721
Score = 161 bits (408), Expect = 6e-39
Identities = 121/424 (28%), Positives = 198/424 (46%), Gaps = 45/424 (10%)
Query: 352 YFIAAEEVIWDY--APVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTV 409
Y++ A E+ WDY + + +D ++ + +F YKK ++ ++ D F +
Sbjct: 24 YYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLF--NIA 81
Query: 410 NPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNN 469
P G+LGP I+A+V DT+ I KNMAS P S++ GV++ + + +
Sbjct: 82 KPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQRE 141
Query: 470 TMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSR 529
V PG ++TY W +L+ + P +D CLT Y S VD+++D+ SGLIG LL+C+
Sbjct: 142 KEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREG 201
Query: 530 SLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTI 589
SL + Q +FAVFDE KSW+ E + + R PK M T+
Sbjct: 202 SLAKEKTQTLHKF--ILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPK------MHTV 253
Query: 590 NGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGE 649
NGYV S+ L C +V WH +GT E+ +I GH+F+ + +L + P+
Sbjct: 254 NGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFL 313
Query: 650 SVTVTMDNVGTWML---------------TSMNSSPRSKKLRLKFRDVKCIPDDDEDSYE 694
+ + ++G ++L ++S P +LR+K + DDD E
Sbjct: 314 TAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDYDDDLTDSE 373
Query: 695 I----FEPPES----TVMATRKMHDR-----LEPEDEESDADYDYQNRLAAALGIRSFRN 741
+ F+ S + + K H + + E+E D+DY L A RS+++
Sbjct: 374 MDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEE----DWDYA-PLVLAPDDRSYKS 428
Query: 742 SSLN 745
LN
Sbjct: 429 QYLN 432
Score = 153 bits (386), Expect = 2e-36
Identities = 97/325 (29%), Positives = 150/325 (46%), Gaps = 46/325 (14%)
Query: 32 RQFYVAAQGISWSYRPEPT-----NSSLNLSVTSFKKIVYREY------EPYFKKEKPQS 80
R +++AA W Y + N + + SV FKK+V++E+ +P ++ E +
Sbjct: 1715 RHYFIAAVERLWDYGMSSSPHVLRNRAQSGSVPQFKKVVFQEFTDGSFTQPLYRGELNEH 1774
Query: 81 TISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDD 140
GLLGP + AEV D I V F+N+A +P S + I Y + D AE +
Sbjct: 1775 L--GLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEE--------DQRQGAEPRKN 1824
Query: 141 AVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTE 200
V P TY W + PT D+ C Y+S +L +D +SGLIGPLL+C TL
Sbjct: 1825 FVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHTNTLNP 1884
Query: 201 GGTQKTFDKQIVLLFAVFDESKSWSQSSSL----------------------MYTVNGYV 238
++ ++ L F +FDE+KSW + ++ + +NGY+
Sbjct: 1885 AHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENYRFHAINGYI 1944
Query: 239 NGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVL---EQNHHKVSAITLVSATSTT 295
T+P + + I W+LL M S + SIHF+G V ++ +K++ L T
Sbjct: 1945 MDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYPGVFET 2004
Query: 296 ANMTVGPEGKWIISSLTPKHLQAGM 320
M G W + L +HL AGM
Sbjct: 2005 VEMLPSKAGIWRVECLIGEHLHAGM 2029
Score = 120 bits (300), Expect = 2e-26
Identities = 67/162 (41%), Positives = 92/162 (56%), Gaps = 11/162 (6%)
Query: 2064 NGCSTPLGMENGKIENKQITASSFKKSWWGDY--WEPFRARLNAQGRVNAWQAKANNNKQ 2121
N C TPLGM +G I + QITAS G Y W P ARL+ G +NAW K +
Sbjct: 2038 NKCQTPLGMASGHIRDFQITAS-------GQYGQWAPKLARLHYSGSINAWSTKEPFS-- 2088
Query: 2122 WLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGN 2181
W+++DLL I I TQG + S +Y+ + I YS G +W+ YR S+ +F GN
Sbjct: 2089 WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGN 2148
Query: 2182 TNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
++ G N FNPPII+R+IR+ P ++ LR+EL GCD+
Sbjct: 2149 VDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDL 2190
>gi|148886707 hephaestin-like 1 [Homo sapiens]
Length = 1159
Score = 440 bits (1132), Expect = e-123
Identities = 284/864 (32%), Positives = 415/864 (48%), Gaps = 97/864 (11%)
Query: 22 GSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTS------------------FKK 63
G G R +Y+ W+Y P+ N S T +KK
Sbjct: 17 GLSGLVGTVTRTYYIGIVEEYWNYVPQGKNVITGKSFTEDKLATLFLERGPNRIGSIYKK 76
Query: 64 IVYREY-EPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKL 122
VYR + + + E P+ G LGP L AEVGD+I +H KN A +P S+HP G+ Y+K
Sbjct: 77 AVYRRFTDGTYSIEIPKPPWLGFLGPILRAEVGDVIVIHLKNFASRPYSLHPHGVFYNKD 136
Query: 123 SEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDF 182
SEGA Y D T K DD V PG+ YTY W + E+ PT D CLT +Y+SH + +D
Sbjct: 137 SEGALYPDGTSGRNKNDDMVPPGKNYTYVWPVREEYAPTPADANCLTWVYHSHIDAPKDI 196
Query: 183 NSGLIGPLLICKKGTLTE-GGTQKTFDKQIVLLFAVFDESKSWS---------------- 225
SGLIGPLL+CK+G L GT+ D++ V++F + DE++SW
Sbjct: 197 CSGLIGPLLVCKEGILNRYSGTRNDVDREFVIMFTLVDENQSWYLNENIKHFCTNPDSVD 256
Query: 226 ------QSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQN 279
Q S+ M+ +NGY+ G P+ +C + +SWHL GM + ++ SI+F G
Sbjct: 257 KKDAVFQRSNKMHALNGYLFGNFPEPDMCVGESVSWHLFGMGNEIDIHSIYFYGNTFISR 316
Query: 280 HHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKI 339
H+ + L AT T M GKW+I+ HLQAGM ++ NC K K+
Sbjct: 317 GHRTDVVNLFPATFLTTEMIAENPGKWMITCQVSDHLQAGMLGQYNVDNC-KSDIFYPKM 375
Query: 340 TREQRRHMKRWEYFIAAEEVIWDYAPV-------IPANMDKKYRSQHLDNFSNQIGKHYK 392
+QRR YFIAAE+++WDYAP +P N + N+IG Y
Sbjct: 376 KGQQRR------YFIAAEKILWDYAPQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYW 429
Query: 393 KVMYTQYEDESFTKHT-VNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVT 451
KV YT++ D +FTK ++ GILGP+I+A+V DTL + F N A + YSI PHGV
Sbjct: 430 KVRYTEFVDATFTKRKRLSAEEAHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVI 489
Query: 452 FSPYED---EVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSD 508
+ D ++ G + V+PGET+TYKW + E PT D CLT Y+S
Sbjct: 490 YDKASDAAPNLDGFVKPGAH------VKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSA 543
Query: 509 VDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCE 568
VD ++D +SGL+G LL+CK L+ G Q+ D E +F VFDEN S Y ++NI KF
Sbjct: 544 VDPIKDTSSGLVGPLLVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIW 603
Query: 569 NPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTG 628
+P + ++D +F +SN M +NGY+ + L C D V WH +GT ++ I F G
Sbjct: 604 HPFSIDKEDKEFVKSNRMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQG 663
Query: 629 HSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDD 688
++ H D+L LFP + + D+ G + + S+ + + C D
Sbjct: 664 NTIHLRGTHRDSLALFPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSC---D 720
Query: 689 DEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEE 748
+ D P E R + E + ++DY + N E
Sbjct: 721 NRD------PSEQRYGMIRTFYIAAE------EVEWDYA--------------PNKNWEF 754
Query: 749 EEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAPSHQQATTAGS 808
E+ ++ A +G F+ + T+ +GS Y ++T E + P ++
Sbjct: 755 EKQHVDARGERHGDIFM-NRTENWIGSQYKKVV-YREYTDGEFVEIKARPPREEHLELLG 812
Query: 809 PLRHLIGKNSVLNSSTAEHSSPYS 832
P+ H N+VL + S PYS
Sbjct: 813 PMIHAEVGNTVLIIFKNKASRPYS 836
Score = 393 bits (1009), Expect = e-108
Identities = 246/696 (35%), Positives = 358/696 (51%), Gaps = 88/696 (12%)
Query: 30 QLRQFYVAAQGISWSYRPEPTNSSLNLSVTS-------------------FKKIVYREY- 69
Q R++++AA+ I W Y P+ N L + + + K+ Y E+
Sbjct: 378 QQRRYFIAAEKILWDYAPQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYWKVRYTEFV 437
Query: 70 EPYFKKEKPQSTIS---GLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGA 126
+ F K K S G+LGP + AEVGD + V F NKADK SI P G+ Y K S+ A
Sbjct: 438 DATFTKRKRLSAEEAHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKASDAA 497
Query: 127 SYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGL 186
LD K V PG +TY+W++ E PT DPPCLT++Y+S + I+D +SGL
Sbjct: 498 PNLDGFV---KPGAHVKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSGL 554
Query: 187 IGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKS-----------WSQ--------- 226
+GPLL+CKKG L GTQK DK+ LLF VFDE+ S W
Sbjct: 555 VGPLLVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIWHPFSIDKEDKE 614
Query: 227 --SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVS 284
S+ M+ VNGY+ G P + +C D +SWHL+G+ + ++ I F G +
Sbjct: 615 FVKSNRMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHLRGTHRD 674
Query: 285 AITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQR 344
++ L +TTA M G + + T HL GM ++ +C + + EQR
Sbjct: 675 SLALFPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSCDNRDPS------EQR 728
Query: 345 RHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLD------------NFSNQIGKHYK 392
M R ++IAAEEV WDYAP N + ++ QH+D N IG YK
Sbjct: 729 YGMIR-TFYIAAEEVEWDYAP----NKNWEFEKQHVDARGERHGDIFMNRTENWIGSQYK 783
Query: 393 KVMYTQYEDESFTKHTVNPNMKED-GILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVT 451
KV+Y +Y D F + P +E +LGP+I A+V +T+ I+FKN ASRPYSI GV
Sbjct: 784 KVVYREYTDGEFVEIKARPPREEHLELLGPMIHAEVGNTVLIIFKNKASRPYSISAQGV- 842
Query: 452 FSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDI 511
+E++S + +PGE TY+WNI + P +D C+ YYS V+
Sbjct: 843 -----EEMDSG-----KQFQVPMTKPGEVKTYRWNIPKRSGPGPSDPNCIPWVYYSTVNF 892
Query: 512 MRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFC-ENP 570
++D SGL+G L+ C+ L+ +G + D E +F VF+EN+SWYL+DNI K+ ++P
Sbjct: 893 VKDTYSGLMGPLITCRKGVLNEKGRRSDVDYEFALLFLVFNENESWYLDDNIKKYLNKDP 952
Query: 571 DEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHS 630
+ KR D F ESN M ING + ++ L D W+ +G++ +I TIH+ S
Sbjct: 953 RDFKRTD-DFEESNRMHAINGKIFGNLHGLIMNEDTMTNWYLLGIGSEVDIHTIHYHAES 1011
Query: 631 FIY---GKRHEDTLTLFPMRGESVTVTMDNVGTWML 663
F++ ED LFP +++ + D+ GTW+L
Sbjct: 1012 FLFKIDKSYREDVYDLFPGTFQTIELFADHPGTWLL 1047
Score = 231 bits (588), Expect = 8e-60
Identities = 140/367 (38%), Positives = 203/367 (55%), Gaps = 36/367 (9%)
Query: 1577 GNRRNYYIAAEEISWDYS-----EFVQRETDI--EDSDDIPEDTT-------YKKVVFRK 1622
G R +YIAAEE+ WDY+ EF ++ D E DI + T YKKVV+R+
Sbjct: 730 GMIRTFYIAAEEVEWDYAPNKNWEFEKQHVDARGERHGDIFMNRTENWIGSQYKKVVYRE 789
Query: 1623 YLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSE 1682
Y D F + R EEHL +LGP+I AEV + + + FKN ASRPYS+ A G+ E+
Sbjct: 790 YTDGEFVEIKARPPREEHLELLGPMIHAEVGNTVLIIFKNKASRPYSISAQGV--EEMDS 847
Query: 1683 GKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHS 1742
GK ++ +P TY W+ +RSGP C W YYS VN KD +S
Sbjct: 848 GKQFQVPM---------TKPGEVKTYRWNIPKRSGPGPSDPNCIPWVYYSTVNFVKDTYS 898
Query: 1743 GLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWY-------YEKKSRSSWRLT 1795
GL+GPL+ C+KG+L++ EF LLF+ F+E +SWY Y K ++ T
Sbjct: 899 GLMGPLITCRKGVLNEKGRRSDVDYEFALLFLVFNENESWYLDDNIKKYLNKDPRDFKRT 958
Query: 1796 SSEMKKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGN 1854
+ ++S+ HAING I+ +L GL M E +LL IG DIH +H+H ++ L +
Sbjct: 959 -DDFEESNRMHAINGKIFGNLHGLIMNEDTMTNWYLLGIGSEVDIHTIHYHAESFLFKID 1017
Query: 1855 KQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIM-DRDCRMPMG- 1912
K ++ V+ L PG+F+T+E+ A PG WLL+ V ++ AGM+T + ++ + D R+P
Sbjct: 1018 KSYREDVYDLFPGTFQTIELFADHPGTWLLHCHVSDHIHAGMETTYTVLRNIDNRIPYST 1077
Query: 1913 LSTGIIS 1919
S G+ S
Sbjct: 1078 TSPGVAS 1084
Score = 224 bits (571), Expect = 7e-58
Identities = 130/340 (38%), Positives = 182/340 (53%), Gaps = 32/340 (9%)
Query: 1580 RNYYIAAEEISWDYSEFVQRETDIEDSDDIPED---------------TTYKKVVFRKYL 1624
R YYI E W+Y V + ++ ED + YKK V+R++
Sbjct: 27 RTYYIGIVEEYWNY---VPQGKNVITGKSFTEDKLATLFLERGPNRIGSIYKKAVYRRFT 83
Query: 1625 DSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGK 1684
D T++ P+ + LG LGPI+RAEV DVI + KN ASRPYSLH HG+ Y K SEG
Sbjct: 84 DGTYSIEIPKPPW---LGFLGPILRAEVGDVIVIHLKNFASRPYSLHPHGVFYNKDSEGA 140
Query: 1685 TYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGL 1744
Y D + K D+ V P +YTYVW E P + C W Y+S ++ KDI SGL
Sbjct: 141 LYPDGTSGRNKNDDMVPPGKNYTYVWPVREEYAPTPADANCLTWVYHSHIDAPKDICSGL 200
Query: 1745 IGPLLICQKGILHKDSNMPMDM-REFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMKK-- 1801
IGPLL+C++GIL++ S D+ REFV++F DE +SWY + + S KK
Sbjct: 201 IGPLLVCKEGILNRYSGTRNDVDREFVIMFTLVDENQSWYLNENIKHFCTNPDSVDKKDA 260
Query: 1802 ----SHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQ 1856
S++ HA+NG ++ + P M E V HL +G DIH ++F+G T + G
Sbjct: 261 VFQRSNKMHALNGYLFGNFPEPDMCVGESVSWHLFGMGNEIDIHSIYFYGNTFISRG--- 317
Query: 1857 HQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGM 1896
H+ V L P +F T EM A PG W++ +V ++ +AGM
Sbjct: 318 HRTDVVNLFPATFLTTEMIAENPGKWMITCQVSDHLQAGM 357
Score = 193 bits (491), Expect = 1e-48
Identities = 126/371 (33%), Positives = 187/371 (50%), Gaps = 26/371 (7%)
Query: 1577 GNRRNYYIAAEEISWDYS-----EFVQRETDIEDSD--------DIPEDTTYKKVVFRKY 1623
G +R Y+IAAE+I WDY+ +F + SD D Y KV + ++
Sbjct: 377 GQQRRYFIAAEKILWDYAPQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYWKVRYTEF 436
Query: 1624 LDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEG 1683
+D+TFTKR E HLGILGP+I+AEV D + V F N A + YS+ HG+ Y+K+S+
Sbjct: 437 VDATFTKRKRLSAEEAHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKASDA 496
Query: 1684 KTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSG 1743
D + K V+P ++TY W E P + C + Y+SAV+P KD SG
Sbjct: 497 APNLDG---FVKPGAHVKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSG 553
Query: 1744 LIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKK-SRSSWRLTS-----S 1797
L+GPLL+C+KG+L+ D +EF LLF FDE S Y+++ + W S
Sbjct: 554 LVGPLLVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIWHPFSIDKEDK 613
Query: 1798 EMKKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQ 1856
E KS+ HA+NG +Y + PGL M +++ V HL+ +G D+H + F G T+ G +
Sbjct: 614 EFVKSNRMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHLRGTHR 673
Query: 1857 HQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTG 1916
L ++P + T M+ G + + + GM + + D R P G
Sbjct: 674 DSLALFPHMA---TTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSCDNRDPSEQRYG 730
Query: 1917 IISDSQIKASE 1927
+I I A E
Sbjct: 731 MIRTFYIAAEE 741
Score = 161 bits (407), Expect = 8e-39
Identities = 101/348 (29%), Positives = 160/348 (45%), Gaps = 61/348 (17%)
Query: 31 LRQFYVAAQGISWSYRPEPT--------------------NSSLNLSVTSFKKIVYREYE 70
+R FY+AA+ + W Y P N + N + +KK+VYREY
Sbjct: 732 IRTFYIAAEEVEWDYAPNKNWEFEKQHVDARGERHGDIFMNRTENWIGSQYKKVVYREYT 791
Query: 71 P----YFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGA 126
K P+ LLGP ++AEVG+ + + FKNKA +P SI QG+ ++ G
Sbjct: 792 DGEFVEIKARPPREEHLELLGPMIHAEVGNTVLIIFKNKASRPYSISAQGVE--EMDSGK 849
Query: 127 SYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGL 186
+ P K PG TY W+I + SGP DP C+ +YYS N ++D SGL
Sbjct: 850 QF---QVPMTK------PGEVKTYRWNIPKRSGPGPSDPNCIPWVYYSTVNFVKDTYSGL 900
Query: 187 IGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWS--------------------- 225
+GPL+ C+KG L E G + D + LLF VF+E++SW
Sbjct: 901 MGPLITCRKGVLNEKGRRSDVDYEFALLFLVFNENESWYLDDNIKKYLNKDPRDFKRTDD 960
Query: 226 -QSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLE---QNHH 281
+ S+ M+ +NG + G + + + +W+LLG+ S ++ +IH++ + +
Sbjct: 961 FEESNRMHAINGKIFGNLHGLIMNEDTMTNWYLLGIGSEVDIHTIHYHAESFLFKIDKSY 1020
Query: 282 KVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQ-AYIDIKN 328
+ L T T + G W++ H+ AGM+ Y ++N
Sbjct: 1021 REDVYDLFPGTFQTIELFADHPGTWLLHCHVSDHIHAGMETTYTVLRN 1068
>gi|4557485 ceruloplasmin precursor [Homo sapiens]
Length = 1065
Score = 399 bits (1026), Expect = e-110
Identities = 232/675 (34%), Positives = 361/675 (53%), Gaps = 48/675 (7%)
Query: 61 FKKIVYREY-EPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRY 119
+KK +Y +Y + F+ + G LGP + AE GD + VH KN A +P + H GI Y
Sbjct: 67 YKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITY 126
Query: 120 SKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLI 179
K EGA Y D+T ++ DD V PG +YTY +E+ P D C+T IY+SH +
Sbjct: 127 YKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAP 186
Query: 180 EDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWS-------------- 225
+D SGLIGPL+ICKK +L + +K D++ V++F+V DE+ SW
Sbjct: 187 KDIASGLIGPLIICKKDSLDKE-KEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEK 245
Query: 226 --------QSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLE 277
Q S+ MY+VNGY G++P +++CA D + W+L GM + ++ + F+GQ L
Sbjct: 246 VDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALT 305
Query: 278 QNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLK 337
++++ I L AT A M G+W++S HL+AG+QA+ ++ C K+ +
Sbjct: 306 NKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQEC-NKSSSKD 364
Query: 338 KITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQ-------HLDNFSNQIGKH 390
I + RH Y+IAAEE+IW+YAP K+ + + + +IG
Sbjct: 365 NIRGKHVRH-----YYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGS 419
Query: 391 YKKVMYTQYEDESFTKHTVN-PNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHG 449
YKK++Y +Y D SFT P + GILGP+I A+V DT+++ F N + P SI P G
Sbjct: 420 YKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIG 479
Query: 450 VTFSPYEDEVNSSFTSGRNNTMIRAVQPG-------ETYTYKWNILEFDEPTENDAQCLT 502
V F+ + ++ S N R+V P ET+TY+W + + PT D CL
Sbjct: 480 VRFNKNNE---GTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLA 536
Query: 503 RPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDN 562
+ YYS VD +DI +GLIG + ICK SL G Q+ D E VFDEN+S LEDN
Sbjct: 537 KMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDN 596
Query: 563 INKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEIL 622
I F PD+V ++D F ESN M ++NG++ + L C D+V W+ S G + ++
Sbjct: 597 IRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVH 656
Query: 623 TIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDV 682
I+F+G+++++ DT LFP ++ + D GT+ + + + + ++ K+
Sbjct: 657 GIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVN 716
Query: 683 KCIPDDDEDSYEIFE 697
+C ++ ++ + E
Sbjct: 717 QCRRQSEDSTFYLGE 731
Score = 383 bits (984), Expect = e-106
Identities = 236/695 (33%), Positives = 351/695 (50%), Gaps = 89/695 (12%)
Query: 31 LRQFYVAAQGISWSYRPEPTNSSLNLSVT-------------------SFKKIVYREYEP 71
+R +Y+AA+ I W+Y P + ++T S+KK+VYREY
Sbjct: 371 VRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTD 430
Query: 72 YF----KKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGAS 127
K+ P+ G+LGP ++AEVGD I+V F NK PLSI P G+R++K +EG
Sbjct: 431 ASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTY 490
Query: 128 YLDHTFPAEKM----DDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFN 183
Y + P + VAP +TYEW++ ++ GPT+ DP CL +YYS + +D
Sbjct: 491 YSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIF 550
Query: 184 SGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWS------------------ 225
+GLIGP+ ICKKG+L G QK DK+ L VFDE++S
Sbjct: 551 TGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKE 610
Query: 226 ----QSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHH 281
Q S+ M+++NG++ G P +T+C D + W+L + ++ I+F+G
Sbjct: 611 DEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGE 670
Query: 282 KVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITR 341
+ L TS T +M EG + + LT H GM+ + C +++ +
Sbjct: 671 RRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLG 730
Query: 342 EQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQ--------IGKHYKK 393
E+ Y+IAA EV WDY+P +K+ N SN IG YKK
Sbjct: 731 ERT-------YYIAAVEVEWDYSP--QREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKK 781
Query: 394 VMYTQYEDESFTKHTVNPNMKED--GILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVT 451
V+Y QY D +F + V +E+ GILGP + A V D +KI+FKNMA+RPYSI+ HGV
Sbjct: 782 VVYRQYTDSTF-RVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQ 840
Query: 452 FSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDI 511
++ + PGET TY W I E D+ C+ YYS VD
Sbjct: 841 ---------------TESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQ 885
Query: 512 MRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPD 571
++D+ SGLIG L++C+ L +R +E +F VFDEN+SWYL+DNI + ++P+
Sbjct: 886 VKDLYSGLIGPLIVCRRPYLKVFNPRRK--LEFALLFLVFDENESWYLDDNIKTYSDHPE 943
Query: 572 EVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSF 631
+V +DD +F ESN M ING + ++ L D V W+ +G + ++ T+HF GHSF
Sbjct: 944 KVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSF 1003
Query: 632 IY---GKRHEDTLTLFPMRGESVTVTMDNVGTWML 663
Y G D +FP +++ + G W+L
Sbjct: 1004 QYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLL 1038
Score = 237 bits (605), Expect = 8e-62
Identities = 138/370 (37%), Positives = 199/370 (53%), Gaps = 45/370 (12%)
Query: 1558 INSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIE------------- 1604
+N R + +YL R YYIAA E+ WDYS QRE + E
Sbjct: 715 VNQCRRQSEDSTFYL-----GERTYYIAAVEVEWDYSP--QREWEKELHHLQEQNVSNAF 767
Query: 1605 -DSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNL 1663
D + + YKKVV+R+Y DSTF R EEHLGILGP + A+V D +++ FKN+
Sbjct: 768 LDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNM 827
Query: 1664 ASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGS 1723
A+RPYS+HAHG+ E S+ T P + TYVW ERSG + S
Sbjct: 828 ATRPYSIHAHGVQTESSTVTPTL---------------PGETLTYVWKIPERSGAGTEDS 872
Query: 1724 ACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWY 1783
AC WAYYS V+ KD++SGLIGPL++C++ L + P EF LLF+ FDE +SWY
Sbjct: 873 ACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFN--PRRKLEFALLFLVFDENESWY 930
Query: 1784 YEKKSRS------SWRLTSSEMKKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGS 1836
+ ++ E +S++ HAING ++ +L GL M+ + V +L+ +G
Sbjct: 931 LDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNE 990
Query: 1837 QDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGM 1896
D+H VHFHG + + V+ + PG+++TLEM PG WLL+ V ++ AGM
Sbjct: 991 IDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGM 1050
Query: 1897 QTPFLIMDRD 1906
+T + ++ +
Sbjct: 1051 ETTYTVLQNE 1060
Score = 220 bits (561), Expect = 1e-56
Identities = 128/352 (36%), Positives = 184/352 (52%), Gaps = 13/352 (3%)
Query: 348 KRWEYFIAAEEVIWDYAPVIPA----NMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDES 403
K Y+I E WDYA ++D ++ + +L N ++IG+ YKK +Y QY DE+
Sbjct: 20 KEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDET 79
Query: 404 FTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSF 463
F P G LGPII+A+ D + + KN+ASRPY+ + HG+T Y E +
Sbjct: 80 FRTTIEKPVWL--GFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGIT---YYKEHEGAI 134
Query: 464 TSGRNNTMIRA---VQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLI 520
RA V PGE YTY E P E D C+TR Y+S +D +DIASGLI
Sbjct: 135 YPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLI 194
Query: 521 GLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKF 580
G L+ICK SLD+ ++ D E +F+V DEN SWYLEDNI +C P++V +D+ F
Sbjct: 195 GPLIICKKDSLDKEK-EKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDF 253
Query: 581 YESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDT 640
ESN M ++NGY S+ L C +D V+W+ +G + ++ F G + DT
Sbjct: 254 QESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDT 313
Query: 641 LTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDS 692
+ LFP + N G WML+ N + L+ F+ +C +D+
Sbjct: 314 INLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDN 365
Score = 203 bits (517), Expect = 1e-51
Identities = 119/342 (34%), Positives = 182/342 (53%), Gaps = 24/342 (7%)
Query: 1580 RNYYIAAEEISWDYS----EFVQRETDIEDSDDIPED------TTYKKVVFRKYLDSTFT 1629
++YYI E +WDY+ E D E S+ ++ YKK ++ +Y D TF
Sbjct: 22 KHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFR 81
Query: 1630 KRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDD 1689
+ + LG LGPII+AE D + V KNLASRPY+ H+HG++Y K EG Y D+
Sbjct: 82 TTIEKPVW---LGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDN 138
Query: 1690 SPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLL 1749
+ ++ + D+ V P YTY+ ATE P C Y+S ++ KDI SGLIGPL+
Sbjct: 139 TTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLI 198
Query: 1750 ICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRS------SWRLTSSEMKKSH 1803
IC+K L K+ +D REFV++F DE SWY E ++ + + ++S+
Sbjct: 199 ICKKDSLDKEKEKHID-REFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESN 257
Query: 1804 EFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVW 1862
+++NG + SLPGL M ++ V+ +L +G D+H FHGQ L NK +++
Sbjct: 258 RMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALT---NKNYRIDTI 314
Query: 1863 PLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMD 1904
L P + M A PG W+L+ + + +AG+Q F + +
Sbjct: 315 NLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQE 356
Score = 193 bits (490), Expect = 2e-48
Identities = 128/377 (33%), Positives = 189/377 (50%), Gaps = 42/377 (11%)
Query: 1559 NSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSE-----FVQRETDIEDSDD---IP 1610
N S DNI ++R +YYIAAEEI W+Y+ F + SD
Sbjct: 358 NKSSSKDNIRGKHVR-------HYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFE 410
Query: 1611 EDTT-----YKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLAS 1665
+ TT YKK+V+R+Y D++FT R RG EEHLGILGP+I AEV D I+V F N +
Sbjct: 411 QGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGA 470
Query: 1666 RPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSS-------YTYVWHATERSGP 1718
P S+ G+ + K++EG Y SP + + +V P++S +TY W + GP
Sbjct: 471 YPLSIEPIGVRFNKNNEGTYY---SPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGP 527
Query: 1719 ESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDE 1778
+ C A YYSAV+P KDI +GLIGP+ IC+KG LH + +EF L FDE
Sbjct: 528 TNADPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDE 587
Query: 1779 KKSWYYEKKSR------SSWRLTSSEMKKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLL 1831
+S E R + ++S++ H++NG +Y + PGL M + + V +L
Sbjct: 588 NESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLF 647
Query: 1832 NIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGEN 1891
+ G D+H ++F G T L G ++ L P + TL M G + + ++
Sbjct: 648 SAGNEADVHGIYFSGNTYLWRGERRDTAN---LFPQTSLTLHMWPDTEGTFNVECLTTDH 704
Query: 1892 QRAGMQTPFLIMDRDCR 1908
GM+ + + CR
Sbjct: 705 YTGGMKQKYTV--NQCR 719
>gi|195963313 hephaestin isoform a [Homo sapiens]
Length = 1161
Score = 397 bits (1021), Expect = e-110
Identities = 241/731 (32%), Positives = 360/731 (49%), Gaps = 73/731 (9%)
Query: 8 LWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTS------- 60
LW L+ + + W Q T+ A R +Y+ + + W+Y P+ N N + S
Sbjct: 10 LWALLFMQSLW----PQLTDGAT-RVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSF 64
Query: 61 -----------FKKIVYREY-EPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADK 108
+KK +Y+EY + + E Q G LGP L AEVGD+I +H KN A +
Sbjct: 65 LKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATR 124
Query: 109 PLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCL 168
P +IHP G+ Y K SEG+ Y D + K DD+V PG + Y W+I E PT DP CL
Sbjct: 125 PYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACL 184
Query: 169 THIYYSHENLIEDFNSGLIGPLLICKKGTLTEGG--TQKTFDKQIVLLFAVFDESKSWS- 225
T IY+SH + D +GLIGPL+ CK+G L ++ D LLF+V DE+ SW
Sbjct: 185 TWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHL 244
Query: 226 ---------------------QSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGP 264
Q S+ M+ +NG+V G +P++ +CA ++WHL GM +
Sbjct: 245 NENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEI 304
Query: 265 ELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYI 324
++ + F+GQ+L H + AT TA M G W+IS H + GMQA
Sbjct: 305 DVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALY 364
Query: 325 DIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVIWDYAPV-----------IPANMDK 373
+K+C + +T + R +YFI A E+ WDY P+ P ++
Sbjct: 365 KVKSC-SMAPPVDLLTGKVR------QYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISD 417
Query: 374 KYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKI 433
K+ S++IG Y KV Y ++DE+F + + GILGP+IRA+V DT+++
Sbjct: 418 KF----FQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQV 473
Query: 434 VFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEP 493
VF N AS+P+S+ PHGV YE + + + ++ +P E TY+W + P
Sbjct: 474 VFYNRASQPFSMQPHGVF---YEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGP 530
Query: 494 TENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDE 553
T D CLT Y+S D +RD SGL+G LL+C++ +L G Q+ D E +F V DE
Sbjct: 531 TAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDE 590
Query: 554 NKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFC 613
NKSWY N + + D F +SN M ING++ ++ L C DTV WH
Sbjct: 591 NKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLL 650
Query: 614 SVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSK 673
+GT+ ++ + F G++ + LFP + DN+GT+ + S R
Sbjct: 651 GLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREA 710
Query: 674 KLRLKFRDVKC 684
+R + +C
Sbjct: 711 GMRAIYNVSQC 721
Score = 367 bits (943), Expect = e-101
Identities = 230/693 (33%), Positives = 344/693 (49%), Gaps = 85/693 (12%)
Query: 30 QLRQFYVAAQGISWSYRPEPTNSSLNLSVT-------------------SFKKIVYREYE 70
++RQ+++ A I W Y P + S ++ ++ K+ Y ++
Sbjct: 381 KVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQ 440
Query: 71 PYFKKEK---PQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGAS 127
+EK + G+LGP + AEVGD I+V F N+A +P S+ P G+ Y K EG
Sbjct: 441 DETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTV 500
Query: 128 YLD-HTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGL 186
Y D ++P P + TY W++ +GPT DP CLT +Y+S + I D NSGL
Sbjct: 501 YNDGSSYPGL----VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL 556
Query: 187 IGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWS--------------------- 225
+GPLL+C+ G L G QK DK+ LLF V DE+KSW
Sbjct: 557 VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG 616
Query: 226 -QSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVS 284
Q S+ M+ +NG++ +P + +C D ++WHLLG+ + ++ + F G ++ +
Sbjct: 617 FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKG 676
Query: 285 AITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQR 344
A L T A M G + I H +AGM+A ++ CP + T QR
Sbjct: 677 AAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGH-----QATPRQR 731
Query: 345 RHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQH---------LDNFSNQIGKHYKKVM 395
R Y+I AEEV WDY P + ++++ +Q L N +G YKK +
Sbjct: 732 YQAARI-YYIMAEEVEWDYCP--DRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAV 788
Query: 396 YTQYEDESFTKHTVNPNMKED-GILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSP 454
+ +Y D +F +E GILGP+I+ +V D L +VFKN ASRPYS++ HGV S
Sbjct: 789 FREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLES- 847
Query: 455 YEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRD 514
A +PGE TY+WNI E P ND+ C++ YYS VD ++D
Sbjct: 848 -------------TTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKD 894
Query: 515 IASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNI-NKFCENPDEV 573
+ SGL+G L IC+ L+ G + D E +F +FDENKSWYLE+N+ ++P +
Sbjct: 895 MYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSI 954
Query: 574 KRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIY 633
D F ESN M ING + ++ L + V W+ ++G ++ TIHF SF+Y
Sbjct: 955 NLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLY 1014
Query: 634 --GKRHE-DTLTLFPMRGESVTVTMDNVGTWML 663
G+ + D + LFP E V + N GTW++
Sbjct: 1015 RNGENYRADVVDLFPGTFEVVEMVASNPGTWLM 1047
Score = 257 bits (657), Expect = 8e-68
Identities = 144/347 (41%), Positives = 193/347 (55%), Gaps = 35/347 (10%)
Query: 1580 RNYYIAAEEISWDYSEFVQRETDIEDSDDIPE-------------DTTYKKVVFRKYLDS 1626
R YYI AEE+ WDY E + + + + YKK VFR+Y D
Sbjct: 736 RIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDG 795
Query: 1627 TFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTY 1686
TF PR EEHLGILGP+I+ EV D++ V FKN ASRPYS+HAHG+
Sbjct: 796 TFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVL---------- 845
Query: 1687 EDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIG 1746
+ + W A +P TY W+ ERSGP SAC +W YYSAV+P KD++SGL+G
Sbjct: 846 -ESTTVW---PLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVG 901
Query: 1747 PLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEK-------KSRSSWRLTSSEM 1799
PL ICQKGIL REF LLF+ FDE KSWY E+ + S L
Sbjct: 902 PLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETF 961
Query: 1800 KKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQ 1858
+S++ HAING +Y +L GL MY+ E V ++L +G D+H +HFH ++ L + ++
Sbjct: 962 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYR 1021
Query: 1859 LGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDR 1905
V L PG+F+ +EM AS PG WL++ V ++ AGM+T F + R
Sbjct: 1022 ADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSR 1068
Score = 220 bits (561), Expect = 1e-56
Identities = 130/375 (34%), Positives = 192/375 (51%), Gaps = 31/375 (8%)
Query: 1576 NGNRRNYYIAAEEISWDYSEFVQR-------ETDIEDSDDIPEDT-----TYKKVVFRKY 1623
+G R YY+ ++ W+Y+ + ++DI S + D TYKK ++++Y
Sbjct: 25 DGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEY 84
Query: 1624 LDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEG 1683
D ++T + + LG LGP+++AEV DVI + KN A+RPY++H HG+ YEK SEG
Sbjct: 85 KDDSYTDEVAQPAW---LGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEG 141
Query: 1684 KTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSG 1743
Y D S K D++V P S+ Y W E P AC W Y+S V+ +DI +G
Sbjct: 142 SLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATG 201
Query: 1744 LIGPLLICQKGILHKDSNMPMDMR----EFVLLFMTFDEKKSWYYEK------KSRSSWR 1793
LIGPL+ C++G L D N P + +F LLF DE SW+ + +S
Sbjct: 202 LIGPLITCKRGAL--DGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVD 259
Query: 1794 LTSSEMKKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLEN 1852
++S+ HAING ++ +LP L M Q+ V HL +G D+H FHGQ L
Sbjct: 260 KEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTR 319
Query: 1853 GNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMG 1912
G H V + P +F T EM +PG WL++ +V + R GMQ + + P+
Sbjct: 320 G---HHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVD 376
Query: 1913 LSTGIISDSQIKASE 1927
L TG + I+A E
Sbjct: 377 LLTGKVRQYFIEAHE 391
Score = 197 bits (500), Expect = 1e-49
Identities = 124/341 (36%), Positives = 173/341 (50%), Gaps = 27/341 (7%)
Query: 1577 GNRRNYYIAAEEISWDYSEF---------VQRETDIEDSDDIPEDT----TYKKVVFRKY 1623
G R Y+I A EI WDY ++ I D + TY KV + +
Sbjct: 380 GKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAF 439
Query: 1624 LDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEG 1683
D TF ++ E + HLGILGP+IRAEV D IQV F N AS+P+S+ HG+ YEK EG
Sbjct: 440 QDETFQEK-MHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEG 498
Query: 1684 KTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSG 1743
Y D S +P TY W +GP + AC W Y+SA +P +D +SG
Sbjct: 499 TVYNDGSSY---PGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSG 555
Query: 1744 LIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSS---WRLTSSEM- 1799
L+GPLL+C+ G L D +EF LLF DE KSWY ++ +RL S ++
Sbjct: 556 LVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIE 615
Query: 1800 --KKSHEFHAINGMIYS-LPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQ 1856
+ S+ HAING ++S LP L M + + V HLL +G D+H V F G T+ G ++
Sbjct: 616 GFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRK 675
Query: 1857 HQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQ 1897
G L P +F M+ G + + + G ++ AGM+
Sbjct: 676 ---GAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMR 713
Score = 161 bits (408), Expect = 6e-39
Identities = 105/363 (28%), Positives = 172/363 (47%), Gaps = 63/363 (17%)
Query: 32 RQFYVAAQGISWSYRPEPT-------------------NSSLNLSVTSFKKIVYREY-EP 71
R +Y+ A+ + W Y P+ + ++ L + +KK V+REY +
Sbjct: 736 RIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDG 795
Query: 72 YFKKEKPQSTIS---GLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASY 128
F+ +P++ G+LGP + EVGDI+ V FKN A +P S+H G+ S
Sbjct: 796 TFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTT------ 849
Query: 129 LDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIG 188
+P A PG TY+W+I E SGP +D C++ IYYS + I+D SGL+G
Sbjct: 850 ---VWPL-----AAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVG 901
Query: 189 PLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSW----------SQS----------- 227
PL IC+KG L G + D++ LLF +FDE+KSW SQ
Sbjct: 902 PLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETF 961
Query: 228 --SSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQ-VLEQN--HHK 282
S+ M+ +NG + + +T+ + ++W++L M +L +IHF+ + L +N +++
Sbjct: 962 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYR 1021
Query: 283 VSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITRE 342
+ L T M G W++ H+ AGM+ + + + L IT+E
Sbjct: 1022 ADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKE 1081
Query: 343 QRR 345
+
Sbjct: 1082 TEK 1084
>gi|195947365 hephaestin isoform c [Homo sapiens]
Length = 1160
Score = 397 bits (1021), Expect = e-110
Identities = 241/731 (32%), Positives = 360/731 (49%), Gaps = 73/731 (9%)
Query: 8 LWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTS------- 60
LW L+ + + W Q T+ A R +Y+ + + W+Y P+ N N + S
Sbjct: 10 LWALLFMQSLW----PQLTDGAT-RVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSF 64
Query: 61 -----------FKKIVYREY-EPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADK 108
+KK +Y+EY + + E Q G LGP L AEVGD+I +H KN A +
Sbjct: 65 LKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATR 124
Query: 109 PLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCL 168
P +IHP G+ Y K SEG+ Y D + K DD+V PG + Y W+I E PT DP CL
Sbjct: 125 PYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACL 184
Query: 169 THIYYSHENLIEDFNSGLIGPLLICKKGTLTEGG--TQKTFDKQIVLLFAVFDESKSWS- 225
T IY+SH + D +GLIGPL+ CK+G L ++ D LLF+V DE+ SW
Sbjct: 185 TWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHL 244
Query: 226 ---------------------QSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGP 264
Q S+ M+ +NG+V G +P++ +CA ++WHL GM +
Sbjct: 245 NENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEI 304
Query: 265 ELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYI 324
++ + F+GQ+L H + AT TA M G W+IS H + GMQA
Sbjct: 305 DVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALY 364
Query: 325 DIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVIWDYAPV-----------IPANMDK 373
+K+C + +T + R +YFI A E+ WDY P+ P ++
Sbjct: 365 KVKSC-SMAPPVDLLTGKVR------QYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISD 417
Query: 374 KYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKI 433
K+ S++IG Y KV Y ++DE+F + + GILGP+IRA+V DT+++
Sbjct: 418 KF----FQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQV 473
Query: 434 VFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEP 493
VF N AS+P+S+ PHGV YE + + + ++ +P E TY+W + P
Sbjct: 474 VFYNRASQPFSMQPHGVF---YEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGP 530
Query: 494 TENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDE 553
T D CLT Y+S D +RD SGL+G LL+C++ +L G Q+ D E +F V DE
Sbjct: 531 TAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDE 590
Query: 554 NKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFC 613
NKSWY N + + D F +SN M ING++ ++ L C DTV WH
Sbjct: 591 NKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLL 650
Query: 614 SVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSK 673
+GT+ ++ + F G++ + LFP + DN+GT+ + S R
Sbjct: 651 GLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREA 710
Query: 674 KLRLKFRDVKC 684
+R + +C
Sbjct: 711 GMRAIYNVSQC 721
Score = 367 bits (943), Expect = e-101
Identities = 230/693 (33%), Positives = 344/693 (49%), Gaps = 85/693 (12%)
Query: 30 QLRQFYVAAQGISWSYRPEPTNSSLNLSVT-------------------SFKKIVYREYE 70
++RQ+++ A I W Y P + S ++ ++ K+ Y ++
Sbjct: 381 KVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQ 440
Query: 71 PYFKKEK---PQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGAS 127
+EK + G+LGP + AEVGD I+V F N+A +P S+ P G+ Y K EG
Sbjct: 441 DETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTV 500
Query: 128 YLD-HTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGL 186
Y D ++P P + TY W++ +GPT DP CLT +Y+S + I D NSGL
Sbjct: 501 YNDGSSYPGL----VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL 556
Query: 187 IGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWS--------------------- 225
+GPLL+C+ G L G QK DK+ LLF V DE+KSW
Sbjct: 557 VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG 616
Query: 226 -QSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVS 284
Q S+ M+ +NG++ +P + +C D ++WHLLG+ + ++ + F G ++ +
Sbjct: 617 FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKG 676
Query: 285 AITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQR 344
A L T A M G + I H +AGM+A ++ CP + T QR
Sbjct: 677 AAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGH-----QATPRQR 731
Query: 345 RHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQH---------LDNFSNQIGKHYKKVM 395
R Y+I AEEV WDY P + ++++ +Q L N +G YKK +
Sbjct: 732 YQAARI-YYIMAEEVEWDYCP--DRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAV 788
Query: 396 YTQYEDESFTKHTVNPNMKED-GILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSP 454
+ +Y D +F +E GILGP+I+ +V D L +VFKN ASRPYS++ HGV S
Sbjct: 789 FREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLES- 847
Query: 455 YEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRD 514
A +PGE TY+WNI E P ND+ C++ YYS VD ++D
Sbjct: 848 -------------TTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKD 894
Query: 515 IASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNI-NKFCENPDEV 573
+ SGL+G L IC+ L+ G + D E +F +FDENKSWYLE+N+ ++P +
Sbjct: 895 MYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSI 954
Query: 574 KRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIY 633
D F ESN M ING + ++ L + V W+ ++G ++ TIHF SF+Y
Sbjct: 955 NLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLY 1014
Query: 634 --GKRHE-DTLTLFPMRGESVTVTMDNVGTWML 663
G+ + D + LFP E V + N GTW++
Sbjct: 1015 RNGENYRADVVDLFPGTFEVVEMVASNPGTWLM 1047
Score = 257 bits (657), Expect = 8e-68
Identities = 144/347 (41%), Positives = 193/347 (55%), Gaps = 35/347 (10%)
Query: 1580 RNYYIAAEEISWDYSEFVQRETDIEDSDDIPE-------------DTTYKKVVFRKYLDS 1626
R YYI AEE+ WDY E + + + + YKK VFR+Y D
Sbjct: 736 RIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDG 795
Query: 1627 TFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTY 1686
TF PR EEHLGILGP+I+ EV D++ V FKN ASRPYS+HAHG+
Sbjct: 796 TFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVL---------- 845
Query: 1687 EDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIG 1746
+ + W A +P TY W+ ERSGP SAC +W YYSAV+P KD++SGL+G
Sbjct: 846 -ESTTVW---PLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVG 901
Query: 1747 PLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEK-------KSRSSWRLTSSEM 1799
PL ICQKGIL REF LLF+ FDE KSWY E+ + S L
Sbjct: 902 PLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETF 961
Query: 1800 KKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQ 1858
+S++ HAING +Y +L GL MY+ E V ++L +G D+H +HFH ++ L + ++
Sbjct: 962 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYR 1021
Query: 1859 LGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDR 1905
V L PG+F+ +EM AS PG WL++ V ++ AGM+T F + R
Sbjct: 1022 ADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSR 1068
Score = 220 bits (561), Expect = 1e-56
Identities = 130/375 (34%), Positives = 192/375 (51%), Gaps = 31/375 (8%)
Query: 1576 NGNRRNYYIAAEEISWDYSEFVQR-------ETDIEDSDDIPEDT-----TYKKVVFRKY 1623
+G R YY+ ++ W+Y+ + ++DI S + D TYKK ++++Y
Sbjct: 25 DGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEY 84
Query: 1624 LDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEG 1683
D ++T + + LG LGP+++AEV DVI + KN A+RPY++H HG+ YEK SEG
Sbjct: 85 KDDSYTDEVAQPAW---LGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEG 141
Query: 1684 KTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSG 1743
Y D S K D++V P S+ Y W E P AC W Y+S V+ +DI +G
Sbjct: 142 SLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATG 201
Query: 1744 LIGPLLICQKGILHKDSNMPMDMR----EFVLLFMTFDEKKSWYYEK------KSRSSWR 1793
LIGPL+ C++G L D N P + +F LLF DE SW+ + +S
Sbjct: 202 LIGPLITCKRGAL--DGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVD 259
Query: 1794 LTSSEMKKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLEN 1852
++S+ HAING ++ +LP L M Q+ V HL +G D+H FHGQ L
Sbjct: 260 KEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTR 319
Query: 1853 GNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMG 1912
G H V + P +F T EM +PG WL++ +V + R GMQ + + P+
Sbjct: 320 G---HHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVD 376
Query: 1913 LSTGIISDSQIKASE 1927
L TG + I+A E
Sbjct: 377 LLTGKVRQYFIEAHE 391
Score = 197 bits (500), Expect = 1e-49
Identities = 124/341 (36%), Positives = 173/341 (50%), Gaps = 27/341 (7%)
Query: 1577 GNRRNYYIAAEEISWDYSEF---------VQRETDIEDSDDIPEDT----TYKKVVFRKY 1623
G R Y+I A EI WDY ++ I D + TY KV + +
Sbjct: 380 GKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAF 439
Query: 1624 LDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEG 1683
D TF ++ E + HLGILGP+IRAEV D IQV F N AS+P+S+ HG+ YEK EG
Sbjct: 440 QDETFQEK-MHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEG 498
Query: 1684 KTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSG 1743
Y D S +P TY W +GP + AC W Y+SA +P +D +SG
Sbjct: 499 TVYNDGSSY---PGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSG 555
Query: 1744 LIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSS---WRLTSSEM- 1799
L+GPLL+C+ G L D +EF LLF DE KSWY ++ +RL S ++
Sbjct: 556 LVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIE 615
Query: 1800 --KKSHEFHAINGMIYS-LPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQ 1856
+ S+ HAING ++S LP L M + + V HLL +G D+H V F G T+ G ++
Sbjct: 616 GFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRK 675
Query: 1857 HQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQ 1897
G L P +F M+ G + + + G ++ AGM+
Sbjct: 676 ---GAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMR 713
Score = 161 bits (408), Expect = 6e-39
Identities = 105/363 (28%), Positives = 172/363 (47%), Gaps = 63/363 (17%)
Query: 32 RQFYVAAQGISWSYRPEPT-------------------NSSLNLSVTSFKKIVYREY-EP 71
R +Y+ A+ + W Y P+ + ++ L + +KK V+REY +
Sbjct: 736 RIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDG 795
Query: 72 YFKKEKPQSTIS---GLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASY 128
F+ +P++ G+LGP + EVGDI+ V FKN A +P S+H G+ S
Sbjct: 796 TFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTT------ 849
Query: 129 LDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIG 188
+P A PG TY+W+I E SGP +D C++ IYYS + I+D SGL+G
Sbjct: 850 ---VWPL-----AAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVG 901
Query: 189 PLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSW----------SQS----------- 227
PL IC+KG L G + D++ LLF +FDE+KSW SQ
Sbjct: 902 PLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETF 961
Query: 228 --SSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQ-VLEQN--HHK 282
S+ M+ +NG + + +T+ + ++W++L M +L +IHF+ + L +N +++
Sbjct: 962 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYR 1021
Query: 283 VSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITRE 342
+ L T M G W++ H+ AGM+ + + + L IT+E
Sbjct: 1022 ADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKE 1081
Query: 343 QRR 345
+
Sbjct: 1082 TEK 1084
>gi|7662254 hephaestin isoform b [Homo sapiens]
Length = 891
Score = 367 bits (943), Expect = e-101
Identities = 230/693 (33%), Positives = 344/693 (49%), Gaps = 85/693 (12%)
Query: 30 QLRQFYVAAQGISWSYRPEPTNSSLNLSVT-------------------SFKKIVYREYE 70
++RQ+++ A I W Y P + S ++ ++ K+ Y ++
Sbjct: 111 KVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQ 170
Query: 71 PYFKKEK---PQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGAS 127
+EK + G+LGP + AEVGD I+V F N+A +P S+ P G+ Y K EG
Sbjct: 171 DETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTV 230
Query: 128 YLD-HTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGL 186
Y D ++P P + TY W++ +GPT DP CLT +Y+S + I D NSGL
Sbjct: 231 YNDGSSYPGL----VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL 286
Query: 187 IGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSW---------------------- 224
+GPLL+C+ G L G QK DK+ LLF V DE+KSW
Sbjct: 287 VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG 346
Query: 225 SQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVS 284
Q S+ M+ +NG++ +P + +C D ++WHLLG+ + ++ + F G ++ +
Sbjct: 347 FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKG 406
Query: 285 AITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQR 344
A L T A M G + I H +AGM+A ++ CP + T QR
Sbjct: 407 AAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPG-----HQATPRQR 461
Query: 345 RHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQ---------HLDNFSNQIGKHYKKVM 395
R Y+I AEEV WDY P + ++++ +Q L N +G YKK +
Sbjct: 462 YQAAR-IYYIMAEEVEWDYCP--DRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAV 518
Query: 396 YTQYEDESFTKHTVNPNMKED-GILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSP 454
+ +Y D +F +E GILGP+I+ +V D L +VFKN ASRPYS++ HGV S
Sbjct: 519 FREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLES- 577
Query: 455 YEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRD 514
A +PGE TY+WNI E P ND+ C++ YYS VD ++D
Sbjct: 578 -------------TTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKD 624
Query: 515 IASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNI-NKFCENPDEV 573
+ SGL+G L IC+ L+ G + D E +F +FDENKSWYLE+N+ ++P +
Sbjct: 625 MYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSI 684
Query: 574 KRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIY 633
D F ESN M ING + ++ L + V W+ ++G ++ TIHF SF+Y
Sbjct: 685 NLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLY 744
Query: 634 --GKRHE-DTLTLFPMRGESVTVTMDNVGTWML 663
G+ + D + LFP E V + N GTW++
Sbjct: 745 RNGENYRADVVDLFPGTFEVVEMVASNPGTWLM 777
Score = 257 bits (657), Expect = 8e-68
Identities = 144/347 (41%), Positives = 193/347 (55%), Gaps = 35/347 (10%)
Query: 1580 RNYYIAAEEISWDYSEFVQRETDIEDSDDIPE-------------DTTYKKVVFRKYLDS 1626
R YYI AEE+ WDY E + + + + YKK VFR+Y D
Sbjct: 466 RIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDG 525
Query: 1627 TFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTY 1686
TF PR EEHLGILGP+I+ EV D++ V FKN ASRPYS+HAHG+
Sbjct: 526 TFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVL---------- 575
Query: 1687 EDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIG 1746
+ + W A +P TY W+ ERSGP SAC +W YYSAV+P KD++SGL+G
Sbjct: 576 -ESTTVW---PLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVG 631
Query: 1747 PLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEK-------KSRSSWRLTSSEM 1799
PL ICQKGIL REF LLF+ FDE KSWY E+ + S L
Sbjct: 632 PLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETF 691
Query: 1800 KKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQ 1858
+S++ HAING +Y +L GL MY+ E V ++L +G D+H +HFH ++ L + ++
Sbjct: 692 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYR 751
Query: 1859 LGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDR 1905
V L PG+F+ +EM AS PG WL++ V ++ AGM+T F + R
Sbjct: 752 ADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSR 798
Score = 254 bits (650), Expect = 5e-67
Identities = 149/465 (32%), Positives = 232/465 (49%), Gaps = 25/465 (5%)
Query: 231 MYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVS 290
M+ +NG+V G +P++ +CA ++WHL GM + ++ + F+GQ+L H +
Sbjct: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60
Query: 291 ATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRW 350
AT TA M G W+IS H + GMQA +K+C + +T + R
Sbjct: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSC-SMAPPVDLLTGKVR------ 113
Query: 351 EYFIAAEEVIWDYAPV-----------IPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQY 399
+YFI A E+ WDY P+ P ++ K+ S++IG Y KV Y +
Sbjct: 114 QYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKF----FQKSSSRIGGTYWKVRYEAF 169
Query: 400 EDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEV 459
+DE+F + + GILGP+IRA+V DT+++VF N AS+P+S+ PHGV YE +
Sbjct: 170 QDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVF---YEKDY 226
Query: 460 NSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGL 519
+ + ++ +P E TY+W + PT D CLT Y+S D +RD SGL
Sbjct: 227 EGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL 286
Query: 520 IGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPK 579
+G LL+C++ +L G Q+ D E +F V DENKSWY N + + D
Sbjct: 287 VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG 346
Query: 580 FYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHED 639
F +SN M ING++ ++ L C DTV WH +GT+ ++ + F G++ +
Sbjct: 347 FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKG 406
Query: 640 TLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKC 684
LFP + DN+GT+ + S R +R + +C
Sbjct: 407 AAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQC 451
Score = 197 bits (500), Expect = 1e-49
Identities = 124/341 (36%), Positives = 173/341 (50%), Gaps = 27/341 (7%)
Query: 1577 GNRRNYYIAAEEISWDYSEF---------VQRETDIEDSDDIPEDT----TYKKVVFRKY 1623
G R Y+I A EI WDY ++ I D + TY KV + +
Sbjct: 110 GKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAF 169
Query: 1624 LDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEG 1683
D TF ++ E + HLGILGP+IRAEV D IQV F N AS+P+S+ HG+ YEK EG
Sbjct: 170 QDETFQEK-MHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEG 228
Query: 1684 KTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSG 1743
Y D S +P TY W +GP + AC W Y+SA +P +D +SG
Sbjct: 229 TVYNDGSSY---PGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSG 285
Query: 1744 LIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSS---WRLTSSEM- 1799
L+GPLL+C+ G L D +EF LLF DE KSWY ++ +RL S ++
Sbjct: 286 LVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIE 345
Query: 1800 --KKSHEFHAINGMIYS-LPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQ 1856
+ S+ HAING ++S LP L M + + V HLL +G D+H V F G T+ G ++
Sbjct: 346 GFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRK 405
Query: 1857 HQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQ 1897
G L P +F M+ G + + + G ++ AGM+
Sbjct: 406 ---GAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMR 443
Score = 161 bits (408), Expect = 6e-39
Identities = 105/363 (28%), Positives = 172/363 (47%), Gaps = 63/363 (17%)
Query: 32 RQFYVAAQGISWSYRPEPT-------------------NSSLNLSVTSFKKIVYREY-EP 71
R +Y+ A+ + W Y P+ + ++ L + +KK V+REY +
Sbjct: 466 RIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDG 525
Query: 72 YFKKEKPQSTIS---GLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASY 128
F+ +P++ G+LGP + EVGDI+ V FKN A +P S+H G+ S
Sbjct: 526 TFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTT------ 579
Query: 129 LDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIG 188
+P A PG TY+W+I E SGP +D C++ IYYS + I+D SGL+G
Sbjct: 580 ---VWPL-----AAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVG 631
Query: 189 PLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSW----------SQS----------- 227
PL IC+KG L G + D++ LLF +FDE+KSW SQ
Sbjct: 632 PLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETF 691
Query: 228 --SSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQ-VLEQN--HHK 282
S+ M+ +NG + + +T+ + ++W++L M +L +IHF+ + L +N +++
Sbjct: 692 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYR 751
Query: 283 VSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITRE 342
+ L T M G W++ H+ AGM+ + + + L IT+E
Sbjct: 752 ADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKE 811
Query: 343 QRR 345
+
Sbjct: 812 TEK 814
Score = 78.2 bits (191), Expect = 8e-14
Identities = 45/123 (36%), Positives = 63/123 (51%), Gaps = 4/123 (3%)
Query: 1806 HAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPL 1864
HAING ++ +LP L M Q+ V HL +G D+H FHGQ L G H V +
Sbjct: 2 HAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRG---HHTDVANI 58
Query: 1865 LPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIK 1924
P +F T EM +PG WL++ +V + R GMQ + + P+ L TG + I+
Sbjct: 59 FPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIE 118
Query: 1925 ASE 1927
A E
Sbjct: 119 AHE 121
>gi|31317224 EGF-like repeats and discoidin I-like domains-containing
protein 3 [Homo sapiens]
Length = 480
Score = 266 bits (679), Expect = 2e-70
Identities = 144/337 (42%), Positives = 198/337 (58%), Gaps = 16/337 (4%)
Query: 1897 QTPFLIMDRDCRM----PMGLSTGIISDSQIKASEF------LGYWEPRLARLNNGGSYN 1946
+ P M R+C+ P+G+ GIIS+ QI AS L W P ARLN G N
Sbjct: 144 ECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLIN 203
Query: 1947 AWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQI 2006
AW+ AAE PWIQ+++Q+++ +TG+ TQGAK Y + +AYS++ W +
Sbjct: 204 AWT----AAENDRWPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAM 259
Query: 2007 FKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGC 2066
+K T M F GN D +T N F PPI A+Y+R+ P TLR+EL GCE++GC
Sbjct: 260 YKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGC 319
Query: 2067 STPLGMENGKIENKQITASSFKKSWWGDY--WEPFRARLNAQGRVNAWQAKANNNKQWLE 2124
S PLGM++G I++ QITASS ++ D WEP +ARL+ QG+VNAW + N+ QWL+
Sbjct: 320 SEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQ 379
Query: 2125 IDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNT 2184
+DLL K+T IITQG K +V SY + YS G W Y+ + DK+F+GN +
Sbjct: 380 VDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDN 439
Query: 2185 KGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGC 2221
H KN +PPI +R IR++P +W I LR EL GC
Sbjct: 440 DTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGC 476
Score = 141 bits (356), Expect = 6e-33
Identities = 66/159 (41%), Positives = 99/159 (62%), Gaps = 1/159 (0%)
Query: 2066 CSTPLGMENGKIENKQITASSFKKSWWG-DYWEPFRARLNAQGRVNAWQAKANNNKQWLE 2124
CS PLG+E G I N+QITASS ++ +G W P+ ARLN +G +NAW A N+ W++
Sbjct: 158 CSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQ 217
Query: 2125 IDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNT 2184
I+L + ++T +ITQG K + S Y+KSY I YS G W Y++K + D +F GN +
Sbjct: 218 INLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDN 277
Query: 2185 KGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
N F PPI ++++R+ P+ + LR+EL GC++
Sbjct: 278 NTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCEL 316
>gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Homo
sapiens]
Length = 387
Score = 253 bits (647), Expect = 1e-66
Identities = 136/323 (42%), Positives = 186/323 (57%), Gaps = 13/323 (4%)
Query: 1907 CRMPMGLSTGIISDSQIKASE----FLG--YWEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
C P+GL G I++SQI AS FLG +W P LARLN G NAW+ +
Sbjct: 70 CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWT----PSSNDDN 125
Query: 1961 PWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNG 2020
PWIQV++ + + +TG+ TQGA Y F VAYS N + F + + F G
Sbjct: 126 PWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFD-FIHDVNKKHKEFVG 184
Query: 2021 NSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENK 2080
N + + + N F+ P+ A+Y+R+ PT + TLR EL GCE+NGC+ PLG++N I +K
Sbjct: 185 NWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDK 244
Query: 2081 QITASSFKKSWWGDY--WEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIIT 2138
QITASS K+W W P ARL+ QG NAW A + N QWL++DL K++T IIT
Sbjct: 245 QITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIIT 304
Query: 2139 QGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIIS 2198
QG ++ S +V SY + YS W Y+ + KIF GN + H KN F PI++
Sbjct: 305 QGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILA 364
Query: 2199 RFIRVIPKTWNQSIALRLELFGC 2221
R++R++P W+ IALRLEL GC
Sbjct: 365 RYVRILPVAWHNRIALRLELLGC 387
Score = 115 bits (289), Expect = 4e-25
Identities = 60/164 (36%), Positives = 95/164 (57%), Gaps = 3/164 (1%)
Query: 2061 CEVNGCSTPLGMENGKIENKQITASSFKKSWWG-DYWEPFRARLNAQGRVNAWQAKANNN 2119
CE C PLG+ENG I N QI ASS + ++ G +W P ARLN G VNAW +N++
Sbjct: 66 CETK-CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDD 124
Query: 2120 KQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFE 2179
W++++LL+ +T ++TQG L+S Y+K++ + YS G E+ + + K F
Sbjct: 125 NPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFD-FIHDVNKKHKEFV 183
Query: 2180 GNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
GN N N F P+ ++++R+ P + + + LR EL GC++
Sbjct: 184 GNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCEL 227
>gi|10518506 coagulation factor VIII isoform b precursor [Homo
sapiens]
Length = 216
Score = 198 bits (503), Expect = 6e-50
Identities = 95/205 (46%), Positives = 138/205 (67%), Gaps = 3/205 (1%)
Query: 2018 FNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKI 2077
F GN D+S IK N F+PPI+ARYIR+ PT R TLR+EL GC++N CS PLGME+ I
Sbjct: 10 FFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAI 69
Query: 2078 ENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAII 2137
+ QITASS+ + + W P +ARL+ QGR NAW+ + NN K+WL++D K K+T +
Sbjct: 70 SDAQITASSYFTNMFAT-WSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVT 128
Query: 2138 TQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPII 2197
TQG KSL + MYVK + I S+ G +W + + K+F+GN ++ V N +PP++
Sbjct: 129 TQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV--KVFQGNQDSFTPVVNSLDPPLL 186
Query: 2198 SRFIRVIPKTWNQSIALRLELFGCD 2222
+R++R+ P++W IALR+E+ GC+
Sbjct: 187 TRYLRIHPQSWVHQIALRMEVLGCE 211
Score = 113 bits (282), Expect = 2e-24
Identities = 63/160 (39%), Positives = 86/160 (53%), Gaps = 10/160 (6%)
Query: 1907 CRMPMGLSTGIISDSQIKASEFL----GYWEPRLARLNNGGSYNAWSVEKLAAEFASKPW 1962
C MP+G+ + ISD+QI AS + W P ARL+ G NAW + K W
Sbjct: 58 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNP----KEW 113
Query: 1963 IQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNS 2022
+QVD QK + +TG+ TQG K L S Y EF ++ S + W +F N V F GN
Sbjct: 114 LQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNG--KVKVFQGNQ 171
Query: 2023 DASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCE 2062
D+ T N DPP++ RY+RI P ++ LR+E+ GCE
Sbjct: 172 DSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE 211
Score = 52.8 bits (125), Expect = 4e-06
Identities = 23/48 (47%), Positives = 33/48 (68%)
Query: 2176 KIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
K+F GN ++ G N FNPPII+R+IR+ P ++ LR+EL GCD+
Sbjct: 8 KVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDL 55
>gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Homo
sapiens]
Length = 335
Score = 194 bits (494), Expect = 6e-49
Identities = 118/323 (36%), Positives = 159/323 (49%), Gaps = 65/323 (20%)
Query: 1907 CRMPMGLSTGIISDSQIKASE----FLG--YWEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
C P+GL G I++SQI AS FLG +W P LARLN G NAW+ +
Sbjct: 70 CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWT----PSSNDDN 125
Query: 1961 PWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNG 2020
PWIQV++ + + +TG+ TQGA Y F VAYS N + F + + F G
Sbjct: 126 PWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFD-FIHDVNKKHKEFVG 184
Query: 2021 NSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENK 2080
N + + + N F+ P+ A+Y+R+ PT + TLR EL GCE+NGC+ PLG++N I +K
Sbjct: 185 NWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDK 244
Query: 2081 QITASSFKKSWWGDY--WEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIIT 2138
QITASS K+W W P ARL+ QG NAW A + N QWL+I
Sbjct: 245 QITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQI------------- 291
Query: 2139 QGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIIS 2198
F GN + H KN F PI++
Sbjct: 292 ---------------------------------------FPGNWDNHSHKKNLFETPILA 312
Query: 2199 RFIRVIPKTWNQSIALRLELFGC 2221
R++R++P W+ IALRLEL GC
Sbjct: 313 RYVRILPVAWHNRIALRLELLGC 335
Score = 115 bits (289), Expect = 4e-25
Identities = 60/164 (36%), Positives = 95/164 (57%), Gaps = 3/164 (1%)
Query: 2061 CEVNGCSTPLGMENGKIENKQITASSFKKSWWG-DYWEPFRARLNAQGRVNAWQAKANNN 2119
CE C PLG+ENG I N QI ASS + ++ G +W P ARLN G VNAW +N++
Sbjct: 66 CETK-CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDD 124
Query: 2120 KQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFE 2179
W++++LL+ +T ++TQG L+S Y+K++ + YS G E+ + + K F
Sbjct: 125 NPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEF-DFIHDVNKKHKEFV 183
Query: 2180 GNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
GN N N F P+ ++++R+ P + + + LR EL GC++
Sbjct: 184 GNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCEL 227
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 151 bits (382), Expect = 6e-36
Identities = 101/333 (30%), Positives = 176/333 (52%), Gaps = 33/333 (9%)
Query: 1907 CRMPMGLSTGIISDSQIKASEFL--GYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQ 1964
C +P+G+ +G I++ QI AS G W P+ +RL+ G N W+ ++K ++Q
Sbjct: 277 CNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNL----DSNKEYLQ 330
Query: 1965 VDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNS 2022
VD++ ++T I TQGA + Y + + S+N +W +++ V F N+
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKV--FQANN 388
Query: 2023 DASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKIENK 2080
DA+ + N+ P++ R++RI P ++ LRLEL GC V CS LGM +G I +
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2081 QITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAK---ANNNKQWLEIDLLKIKKITAII 2137
QI+ASS ++ W P ARL + + W + A ++WL++DL K + +I
Sbjct: 449 QISASSTQEY----LWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTVKGVI 502
Query: 2138 TQGCK------SLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN-TKGHVKN 2190
QG + ++ + +V+ + + YS G +W+ + + K+FEGN + ++
Sbjct: 503 IQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRR 562
Query: 2191 FFNPPIISRFIRVIPKTWNQS-IALRLELFGCD 2222
F PI ++++RV P+ W+ + I +RLE+ GCD
Sbjct: 563 F--DPIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
Score = 122 bits (305), Expect = 5e-27
Identities = 65/160 (40%), Positives = 100/160 (62%), Gaps = 9/160 (5%)
Query: 2066 CSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEI 2125
C+ PLGME+G+I N+QI+ASS ++ W P ++RL+ G N W ++NK++L++
Sbjct: 277 CNVPLGMESGRIANEQISASS---TYSDGRWTPQQSRLH--GDDNGWTPNLDSNKEYLQV 331
Query: 2126 DLLKIKKITAIITQGCKSLSSE--MYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN 2183
DL + +TAI TQG S ++ YVKSY + S G +W YR + K+F+ N +
Sbjct: 332 DLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKN--HKVFQANND 389
Query: 2184 TKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
V N + P+++RF+R+ P+TW+ IALRLELFGC +
Sbjct: 390 ATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRV 429
Score = 73.2 bits (178), Expect = 3e-12
Identities = 52/169 (30%), Positives = 83/169 (49%), Gaps = 12/169 (7%)
Query: 1902 IMDRDCRMPMGLSTGIISDSQIKASEFLGY-WEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
+ D C +G+ +G+I+DSQI AS Y W P ARL + S + W ++ +
Sbjct: 429 VTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVS--SRSGW-FPRIPQAQPGE 485
Query: 1961 PWIQVDMQKEVIITGIQTQGAK------HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRN 2014
W+QVD+ + G+ QGA+ + +F V+YS N +W+ + T+
Sbjct: 486 EWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQ 545
Query: 2015 VMYFNGNSDASTIKENQFDPPIVARYIRISPTR-AYNRPTLRLELQGCE 2062
F GN T +FD PI A+Y+R+ P R + +RLE+ GC+
Sbjct: 546 PKLFEGNMHYDTPDIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 151 bits (382), Expect = 6e-36
Identities = 101/333 (30%), Positives = 176/333 (52%), Gaps = 33/333 (9%)
Query: 1907 CRMPMGLSTGIISDSQIKASEFL--GYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQ 1964
C +P+G+ +G I++ QI AS G W P+ +RL+ G N W+ ++K ++Q
Sbjct: 277 CNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNL----DSNKEYLQ 330
Query: 1965 VDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNS 2022
VD++ ++T I TQGA + Y + + S+N +W +++ V F N+
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKV--FQANN 388
Query: 2023 DASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKIENK 2080
DA+ + N+ P++ R++RI P ++ LRLEL GC V CS LGM +G I +
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2081 QITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAK---ANNNKQWLEIDLLKIKKITAII 2137
QI+ASS ++ W P ARL + + W + A ++WL++DL K + +I
Sbjct: 449 QISASSTQEY----LWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTVKGVI 502
Query: 2138 TQGCK------SLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN-TKGHVKN 2190
QG + ++ + +V+ + + YS G +W+ + + K+FEGN + ++
Sbjct: 503 IQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRR 562
Query: 2191 FFNPPIISRFIRVIPKTWNQS-IALRLELFGCD 2222
F PI ++++RV P+ W+ + I +RLE+ GCD
Sbjct: 563 F--DPIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
Score = 122 bits (305), Expect = 5e-27
Identities = 65/160 (40%), Positives = 100/160 (62%), Gaps = 9/160 (5%)
Query: 2066 CSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEI 2125
C+ PLGME+G+I N+QI+ASS ++ W P ++RL+ G N W ++NK++L++
Sbjct: 277 CNVPLGMESGRIANEQISASS---TYSDGRWTPQQSRLH--GDDNGWTPNLDSNKEYLQV 331
Query: 2126 DLLKIKKITAIITQGCKSLSSE--MYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN 2183
DL + +TAI TQG S ++ YVKSY + S G +W YR + K+F+ N +
Sbjct: 332 DLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKN--HKVFQANND 389
Query: 2184 TKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
V N + P+++RF+R+ P+TW+ IALRLELFGC +
Sbjct: 390 ATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRV 429
Score = 73.2 bits (178), Expect = 3e-12
Identities = 52/169 (30%), Positives = 83/169 (49%), Gaps = 12/169 (7%)
Query: 1902 IMDRDCRMPMGLSTGIISDSQIKASEFLGY-WEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
+ D C +G+ +G+I+DSQI AS Y W P ARL + S + W ++ +
Sbjct: 429 VTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVS--SRSGW-FPRIPQAQPGE 485
Query: 1961 PWIQVDMQKEVIITGIQTQGAK------HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRN 2014
W+QVD+ + G+ QGA+ + +F V+YS N +W+ + T+
Sbjct: 486 EWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQ 545
Query: 2015 VMYFNGNSDASTIKENQFDPPIVARYIRISPTR-AYNRPTLRLELQGCE 2062
F GN T +FD PI A+Y+R+ P R + +RLE+ GC+
Sbjct: 546 PKLFEGNMHYDTPDIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 151 bits (382), Expect = 6e-36
Identities = 101/333 (30%), Positives = 176/333 (52%), Gaps = 33/333 (9%)
Query: 1907 CRMPMGLSTGIISDSQIKASEFL--GYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQ 1964
C +P+G+ +G I++ QI AS G W P+ +RL+ G N W+ ++K ++Q
Sbjct: 277 CNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNL----DSNKEYLQ 330
Query: 1965 VDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNS 2022
VD++ ++T I TQGA + Y + + S+N +W +++ V F N+
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKV--FQANN 388
Query: 2023 DASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKIENK 2080
DA+ + N+ P++ R++RI P ++ LRLEL GC V CS LGM +G I +
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2081 QITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAK---ANNNKQWLEIDLLKIKKITAII 2137
QI+ASS ++ W P ARL + + W + A ++WL++DL K + +I
Sbjct: 449 QISASSTQEY----LWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTVKGVI 502
Query: 2138 TQGCK------SLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN-TKGHVKN 2190
QG + ++ + +V+ + + YS G +W+ + + K+FEGN + ++
Sbjct: 503 IQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRR 562
Query: 2191 FFNPPIISRFIRVIPKTWNQS-IALRLELFGCD 2222
F PI ++++RV P+ W+ + I +RLE+ GCD
Sbjct: 563 F--DPIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
Score = 122 bits (305), Expect = 5e-27
Identities = 65/160 (40%), Positives = 100/160 (62%), Gaps = 9/160 (5%)
Query: 2066 CSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEI 2125
C+ PLGME+G+I N+QI+ASS ++ W P ++RL+ G N W ++NK++L++
Sbjct: 277 CNVPLGMESGRIANEQISASS---TYSDGRWTPQQSRLH--GDDNGWTPNLDSNKEYLQV 331
Query: 2126 DLLKIKKITAIITQGCKSLSSE--MYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN 2183
DL + +TAI TQG S ++ YVKSY + S G +W YR + K+F+ N +
Sbjct: 332 DLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKN--HKVFQANND 389
Query: 2184 TKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
V N + P+++RF+R+ P+TW+ IALRLELFGC +
Sbjct: 390 ATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRV 429
Score = 73.2 bits (178), Expect = 3e-12
Identities = 52/169 (30%), Positives = 83/169 (49%), Gaps = 12/169 (7%)
Query: 1902 IMDRDCRMPMGLSTGIISDSQIKASEFLGY-WEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
+ D C +G+ +G+I+DSQI AS Y W P ARL + S + W ++ +
Sbjct: 429 VTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVS--SRSGW-FPRIPQAQPGE 485
Query: 1961 PWIQVDMQKEVIITGIQTQGAK------HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRN 2014
W+QVD+ + G+ QGA+ + +F V+YS N +W+ + T+
Sbjct: 486 EWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQ 545
Query: 2015 VMYFNGNSDASTIKENQFDPPIVARYIRISPTR-AYNRPTLRLELQGCE 2062
F GN T +FD PI A+Y+R+ P R + +RLE+ GC+
Sbjct: 546 PKLFEGNMHYDTPDIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 151 bits (382), Expect = 6e-36
Identities = 101/333 (30%), Positives = 176/333 (52%), Gaps = 33/333 (9%)
Query: 1907 CRMPMGLSTGIISDSQIKASEFL--GYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQ 1964
C +P+G+ +G I++ QI AS G W P+ +RL+ G N W+ ++K ++Q
Sbjct: 277 CNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNL----DSNKEYLQ 330
Query: 1965 VDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNS 2022
VD++ ++T I TQGA + Y + + S+N +W +++ V F N+
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKV--FQANN 388
Query: 2023 DASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKIENK 2080
DA+ + N+ P++ R++RI P ++ LRLEL GC V CS LGM +G I +
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2081 QITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAK---ANNNKQWLEIDLLKIKKITAII 2137
QI+ASS ++ W P ARL + + W + A ++WL++DL K + +I
Sbjct: 449 QISASSTQEY----LWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTVKGVI 502
Query: 2138 TQGCK------SLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN-TKGHVKN 2190
QG + ++ + +V+ + + YS G +W+ + + K+FEGN + ++
Sbjct: 503 IQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRR 562
Query: 2191 FFNPPIISRFIRVIPKTWNQS-IALRLELFGCD 2222
F PI ++++RV P+ W+ + I +RLE+ GCD
Sbjct: 563 F--DPIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
Score = 122 bits (305), Expect = 5e-27
Identities = 65/160 (40%), Positives = 100/160 (62%), Gaps = 9/160 (5%)
Query: 2066 CSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEI 2125
C+ PLGME+G+I N+QI+ASS ++ W P ++RL+ G N W ++NK++L++
Sbjct: 277 CNVPLGMESGRIANEQISASS---TYSDGRWTPQQSRLH--GDDNGWTPNLDSNKEYLQV 331
Query: 2126 DLLKIKKITAIITQGCKSLSSE--MYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN 2183
DL + +TAI TQG S ++ YVKSY + S G +W YR + K+F+ N +
Sbjct: 332 DLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKN--HKVFQANND 389
Query: 2184 TKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
V N + P+++RF+R+ P+TW+ IALRLELFGC +
Sbjct: 390 ATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRV 429
Score = 73.2 bits (178), Expect = 3e-12
Identities = 52/169 (30%), Positives = 83/169 (49%), Gaps = 12/169 (7%)
Query: 1902 IMDRDCRMPMGLSTGIISDSQIKASEFLGY-WEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
+ D C +G+ +G+I+DSQI AS Y W P ARL + S + W ++ +
Sbjct: 429 VTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVS--SRSGW-FPRIPQAQPGE 485
Query: 1961 PWIQVDMQKEVIITGIQTQGAK------HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRN 2014
W+QVD+ + G+ QGA+ + +F V+YS N +W+ + T+
Sbjct: 486 EWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQ 545
Query: 2015 VMYFNGNSDASTIKENQFDPPIVARYIRISPTR-AYNRPTLRLELQGCE 2062
F GN T +FD PI A+Y+R+ P R + +RLE+ GC+
Sbjct: 546 PKLFEGNMHYDTPDIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 151 bits (382), Expect = 6e-36
Identities = 101/333 (30%), Positives = 176/333 (52%), Gaps = 33/333 (9%)
Query: 1907 CRMPMGLSTGIISDSQIKASEFL--GYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQ 1964
C +P+G+ +G I++ QI AS G W P+ +RL+ G N W+ ++K ++Q
Sbjct: 277 CNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNL----DSNKEYLQ 330
Query: 1965 VDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNS 2022
VD++ ++T I TQGA + Y + + S+N +W +++ V F N+
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKV--FQANN 388
Query: 2023 DASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKIENK 2080
DA+ + N+ P++ R++RI P ++ LRLEL GC V CS LGM +G I +
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2081 QITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAK---ANNNKQWLEIDLLKIKKITAII 2137
QI+ASS ++ W P ARL + + W + A ++WL++DL K + +I
Sbjct: 449 QISASSTQEY----LWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTVKGVI 502
Query: 2138 TQGCK------SLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN-TKGHVKN 2190
QG + ++ + +V+ + + YS G +W+ + + K+FEGN + ++
Sbjct: 503 IQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRR 562
Query: 2191 FFNPPIISRFIRVIPKTWNQS-IALRLELFGCD 2222
F PI ++++RV P+ W+ + I +RLE+ GCD
Sbjct: 563 F--DPIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
Score = 122 bits (305), Expect = 5e-27
Identities = 65/160 (40%), Positives = 100/160 (62%), Gaps = 9/160 (5%)
Query: 2066 CSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEI 2125
C+ PLGME+G+I N+QI+ASS ++ W P ++RL+ G N W ++NK++L++
Sbjct: 277 CNVPLGMESGRIANEQISASS---TYSDGRWTPQQSRLH--GDDNGWTPNLDSNKEYLQV 331
Query: 2126 DLLKIKKITAIITQGCKSLSSE--MYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN 2183
DL + +TAI TQG S ++ YVKSY + S G +W YR + K+F+ N +
Sbjct: 332 DLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKN--HKVFQANND 389
Query: 2184 TKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
V N + P+++RF+R+ P+TW+ IALRLELFGC +
Sbjct: 390 ATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRV 429
Score = 73.2 bits (178), Expect = 3e-12
Identities = 52/169 (30%), Positives = 83/169 (49%), Gaps = 12/169 (7%)
Query: 1902 IMDRDCRMPMGLSTGIISDSQIKASEFLGY-WEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
+ D C +G+ +G+I+DSQI AS Y W P ARL + S + W ++ +
Sbjct: 429 VTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVS--SRSGW-FPRIPQAQPGE 485
Query: 1961 PWIQVDMQKEVIITGIQTQGAK------HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRN 2014
W+QVD+ + G+ QGA+ + +F V+YS N +W+ + T+
Sbjct: 486 EWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQ 545
Query: 2015 VMYFNGNSDASTIKENQFDPPIVARYIRISPTR-AYNRPTLRLELQGCE 2062
F GN T +FD PI A+Y+R+ P R + +RLE+ GC+
Sbjct: 546 PKLFEGNMHYDTPDIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
Length = 609
Score = 138 bits (347), Expect = 7e-32
Identities = 105/331 (31%), Positives = 161/331 (48%), Gaps = 28/331 (8%)
Query: 1904 DRDCRMPMGLSTGIISDSQIKAS-EFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPW 1962
D C +G+ +G I QI AS ++ W +RLN N W+ E + + W
Sbjct: 272 DFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNY--PENGWT----PGEDSYREW 325
Query: 1963 IQVDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFK-GNSTRNVMYFN 2019
IQVD+ +T + TQGA K K Y + + SSN +W K GN + F
Sbjct: 326 IQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKP---VLFQ 382
Query: 2020 GNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKI 2077
GN++ + + F P++ R++RI P ++R E+ GC++ CS LGM +G I
Sbjct: 383 GNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLI 442
Query: 2078 ENKQITASSFKKSWWGDY-WEPFRARLNAQGRVNAWQ---AKANNNKQWLEIDLLKIKKI 2133
+ QIT+S+ GD W P RL + W A + +WL+IDL + K +
Sbjct: 443 SDSQITSSN-----QGDRNWMPENIRLVTSR--SGWALPPAPHSYINEWLQIDLGEEKIV 495
Query: 2134 TAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFN 2193
II QG K ++++++ + I YS G +WK S K FEGN N F
Sbjct: 496 RGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF- 554
Query: 2194 PPIISRFIRVIP-KTWNQSIALRLELFGCDI 2223
P + +RFIR+ P + + + LR+EL GC++
Sbjct: 555 PALSTRFIRIYPERATHGGLGLRMELLGCEV 585
Score = 95.9 bits (237), Expect = 4e-19
Identities = 62/183 (33%), Positives = 97/183 (53%), Gaps = 6/183 (3%)
Query: 1902 IMDRDCRMPMGLSTGIISDSQIKAS-EFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
I D C +G+ +G+ISDSQI +S + W P RL S + W++ + ++
Sbjct: 426 ITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVT--SRSGWALPPAPHSYINE 483
Query: 1961 PWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNG 2020
W+Q+D+ +E I+ GI QG KH + +F + YS+N +W++ +S R F G
Sbjct: 484 -WLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEG 542
Query: 2021 NSDASTIKENQFDPPIVARYIRISPTRA-YNRPTLRLELQGCEVNGCSTPLGMENGKIEN 2079
N++ T + F P + R+IRI P RA + LR+EL GCEV G +T L E + +
Sbjct: 543 NNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTVID 601
Query: 2080 KQI 2082
I
Sbjct: 602 STI 604
>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
Length = 644
Score = 138 bits (347), Expect = 7e-32
Identities = 105/331 (31%), Positives = 161/331 (48%), Gaps = 28/331 (8%)
Query: 1904 DRDCRMPMGLSTGIISDSQIKAS-EFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPW 1962
D C +G+ +G I QI AS ++ W +RLN N W+ E + + W
Sbjct: 272 DFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNY--PENGWT----PGEDSYREW 325
Query: 1963 IQVDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFK-GNSTRNVMYFN 2019
IQVD+ +T + TQGA K K Y + + SSN +W K GN + F
Sbjct: 326 IQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKP---VLFQ 382
Query: 2020 GNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKI 2077
GN++ + + F P++ R++RI P ++R E+ GC++ CS LGM +G I
Sbjct: 383 GNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLI 442
Query: 2078 ENKQITASSFKKSWWGDY-WEPFRARLNAQGRVNAWQ---AKANNNKQWLEIDLLKIKKI 2133
+ QIT+S+ GD W P RL + W A + +WL+IDL + K +
Sbjct: 443 SDSQITSSN-----QGDRNWMPENIRLVTSR--SGWALPPAPHSYINEWLQIDLGEEKIV 495
Query: 2134 TAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFN 2193
II QG K ++++++ + I YS G +WK S K FEGN N F
Sbjct: 496 RGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF- 554
Query: 2194 PPIISRFIRVIP-KTWNQSIALRLELFGCDI 2223
P + +RFIR+ P + + + LR+EL GC++
Sbjct: 555 PALSTRFIRIYPERATHGGLGLRMELLGCEV 585
Score = 91.3 bits (225), Expect = 1e-17
Identities = 61/176 (34%), Positives = 94/176 (53%), Gaps = 10/176 (5%)
Query: 1902 IMDRDCRMPMGLSTGIISDSQIKAS-EFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
I D C +G+ +G+ISDSQI +S + W P RL S + W++ + ++
Sbjct: 426 ITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVT--SRSGWALPPAPHSYINE 483
Query: 1961 PWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNG 2020
W+Q+D+ +E I+ GI QG KH + +F + YS+N +W++ +S R F G
Sbjct: 484 -WLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEG 542
Query: 2021 NSDASTIKENQFDPPIVARYIRISPTRA-YNRPTLRLELQGCEVN----GCSTPLG 2071
N++ T + F P + R+IRI P RA + LR+EL GCEV G +TP G
Sbjct: 543 NNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNG 597
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 138 bits (347), Expect = 7e-32
Identities = 105/331 (31%), Positives = 161/331 (48%), Gaps = 28/331 (8%)
Query: 1904 DRDCRMPMGLSTGIISDSQIKAS-EFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPW 1962
D C +G+ +G I QI AS ++ W +RLN N W+ E + + W
Sbjct: 272 DFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNY--PENGWT----PGEDSYREW 325
Query: 1963 IQVDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFK-GNSTRNVMYFN 2019
IQVD+ +T + TQGA K K Y + + SSN +W K GN + F
Sbjct: 326 IQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKP---VLFQ 382
Query: 2020 GNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKI 2077
GN++ + + F P++ R++RI P ++R E+ GC++ CS LGM +G I
Sbjct: 383 GNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLI 442
Query: 2078 ENKQITASSFKKSWWGDY-WEPFRARLNAQGRVNAWQ---AKANNNKQWLEIDLLKIKKI 2133
+ QIT+S+ GD W P RL + W A + +WL+IDL + K +
Sbjct: 443 SDSQITSSN-----QGDRNWMPENIRLVTSR--SGWALPPAPHSYINEWLQIDLGEEKIV 495
Query: 2134 TAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFN 2193
II QG K ++++++ + I YS G +WK S K FEGN N F
Sbjct: 496 RGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF- 554
Query: 2194 PPIISRFIRVIP-KTWNQSIALRLELFGCDI 2223
P + +RFIR+ P + + + LR+EL GC++
Sbjct: 555 PALSTRFIRIYPERATHGGLGLRMELLGCEV 585
Score = 91.3 bits (225), Expect = 1e-17
Identities = 61/176 (34%), Positives = 94/176 (53%), Gaps = 10/176 (5%)
Query: 1902 IMDRDCRMPMGLSTGIISDSQIKAS-EFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
I D C +G+ +G+ISDSQI +S + W P RL S + W++ + ++
Sbjct: 426 ITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVT--SRSGWALPPAPHSYINE 483
Query: 1961 PWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNG 2020
W+Q+D+ +E I+ GI QG KH + +F + YS+N +W++ +S R F G
Sbjct: 484 -WLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEG 542
Query: 2021 NSDASTIKENQFDPPIVARYIRISPTRA-YNRPTLRLELQGCEVN----GCSTPLG 2071
N++ T + F P + R+IRI P RA + LR+EL GCEV G +TP G
Sbjct: 543 NNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNG 597
>gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo
sapiens]
Length = 775
Score = 136 bits (343), Expect = 2e-31
Identities = 77/166 (46%), Positives = 98/166 (59%), Gaps = 10/166 (6%)
Query: 2062 EVNGCSTPLGMENGKIENKQITASSFKKSWWGDY------WEPFRARLNAQGRVNAWQAK 2115
+ +GC LGME+G I + QITASS + W D+ W+P +ARL G W A
Sbjct: 288 KTSGCYGTLGMESGVIADPQITASSVLE--WTDHTGQENSWKPKKARLKKPGP--PWAAF 343
Query: 2116 ANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVD 2175
A + QWL+IDL K KKIT IIT G + YV +Y I YS+ G +W YR D
Sbjct: 344 ATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQD 403
Query: 2176 KIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGC 2221
KIF+GN + V+N F PPII+RFIRV P W Q IA+++EL GC
Sbjct: 404 KIFQGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGC 449
Score = 94.0 bits (232), Expect = 1e-18
Identities = 55/174 (31%), Positives = 86/174 (49%), Gaps = 19/174 (10%)
Query: 1900 FLIMDRDCRMPMGLSTGIISDSQIKASEFLGY---------WEPRLARLNNGGSYNAWSV 1950
F C +G+ +G+I+D QI AS L + W+P+ ARL G W
Sbjct: 285 FTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGP--PW-- 340
Query: 1951 EKLAAEFASKP--WIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFK 2008
A FA+ W+Q+D+ KE ITGI T G+ + Y + + + YS + W +++
Sbjct: 341 ----AAFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYR 396
Query: 2009 GNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCE 2062
F GN D N F PPI+AR+IR++PT+ + +++EL GC+
Sbjct: 397 EPGVEQDKIFQGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGCQ 450
>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
Length = 555
Score = 124 bits (310), Expect = 1e-27
Identities = 82/274 (29%), Positives = 142/274 (51%), Gaps = 29/274 (10%)
Query: 1907 CRMPMGLSTGIISDSQIKASEFL--GYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQ 1964
C +P+G+ +G I++ QI AS G W P+ +RL+ G N W+ ++K ++Q
Sbjct: 277 CNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNL----DSNKEYLQ 330
Query: 1965 VDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNS 2022
VD++ ++T I TQGA + Y + + S+N +W +++ V F N+
Sbjct: 331 VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKV--FQANN 388
Query: 2023 DASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKIENK 2080
DA+ + N+ P++ R++RI P ++ LRLEL GC V CS LGM +G I +
Sbjct: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
Query: 2081 QITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAK---ANNNKQWLEIDLLKIKKITAII 2137
QI+ASS ++ W P ARL + + W + A ++WL++DL K + +I
Sbjct: 449 QISASSTQEY----LWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTVKGVI 502
Query: 2138 TQGCK------SLSSEMYVKSYTIHYSEQGVEWK 2165
QG + ++ + +V+ + + YS G +W+
Sbjct: 503 IQGARGGDSITAVEARAFVRKFKVSYSLNGKDWE 536
Score = 122 bits (305), Expect = 5e-27
Identities = 65/160 (40%), Positives = 100/160 (62%), Gaps = 9/160 (5%)
Query: 2066 CSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEI 2125
C+ PLGME+G+I N+QI+ASS ++ W P ++RL+ G N W ++NK++L++
Sbjct: 277 CNVPLGMESGRIANEQISASS---TYSDGRWTPQQSRLH--GDDNGWTPNLDSNKEYLQV 331
Query: 2126 DLLKIKKITAIITQGCKSLSSE--MYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN 2183
DL + +TAI TQG S ++ YVKSY + S G +W YR + K+F+ N +
Sbjct: 332 DLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKN--HKVFQANND 389
Query: 2184 TKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
V N + P+++RF+R+ P+TW+ IALRLELFGC +
Sbjct: 390 ATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRV 429
Score = 50.4 bits (119), Expect = 2e-05
Identities = 34/119 (28%), Positives = 57/119 (47%), Gaps = 10/119 (8%)
Query: 1902 IMDRDCRMPMGLSTGIISDSQIKASEFLGY-WEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
+ D C +G+ +G+I+DSQI AS Y W P ARL + S + W ++ +
Sbjct: 429 VTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVS--SRSGW-FPRIPQAQPGE 485
Query: 1961 PWIQVDMQKEVIITGIQTQGAK------HYLKSCYTTEFYVAYSSNQINWQIFKGNSTR 2013
W+QVD+ + G+ QGA+ + +F V+YS N +W+ + T+
Sbjct: 486 EWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQ 544
>gi|27735143 discoidin, CUB and LCCL domain containing 1 [Homo
sapiens]
Length = 539
Score = 123 bits (308), Expect = 2e-27
Identities = 72/169 (42%), Positives = 102/169 (60%), Gaps = 16/169 (9%)
Query: 2064 NGCSTPLGMENGKIENKQITASSFKKSWW-----GD--YWEPFRARLNAQGRVNAWQAKA 2116
NGCS L E + QI ASS SW GD +W P +ARL QG A +
Sbjct: 253 NGCSRSLSFE----PDGQIRASS---SWQSVNESGDQVHWSPGQARLQDQGPSWASGDSS 305
Query: 2117 NNNK--QWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMV 2174
NN+K +WLEIDL + KKIT I T G + YVKS+ +++ +WK Y+ +
Sbjct: 306 NNHKPREWLEIDLGEKKKITGIRTTGSTQSNFNFYVKSFVMNFKNNNSKWKTYKGIVNNE 365
Query: 2175 DKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
+K+F+GN+N + V+N F PPI++R++RV+P+TW+Q IAL++EL GC I
Sbjct: 366 EKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWHQRIALKVELIGCQI 414
Score = 85.5 bits (210), Expect = 5e-16
Identities = 42/133 (31%), Positives = 71/133 (53%), Gaps = 2/133 (1%)
Query: 1931 YWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYT 1990
+W P ARL + G +W+ + + W+++D+ ++ ITGI+T G+ + Y
Sbjct: 284 HWSPGQARLQDQGP--SWASGDSSNNHKPREWLEIDLGEKKKITGIRTTGSTQSNFNFYV 341
Query: 1991 TEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYN 2050
F + + +N W+ +KG F GNS+ +N F PPIVARY+R+ P +
Sbjct: 342 KSFVMNFKNNNSKWKTYKGIVNNEEKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWHQ 401
Query: 2051 RPTLRLELQGCEV 2063
R L++EL GC++
Sbjct: 402 RIALKVELIGCQI 414
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 111 bits (277), Expect = 9e-24
Identities = 114/444 (25%), Positives = 168/444 (37%), Gaps = 28/444 (6%)
Query: 1075 ETSLPTDLNQTLPSMDFGWIASLPDHNQNSSN-DTGQASCPPGLYQTVPPEEHYQTFPIQ 1133
E L LN+ +P + P+ + S + S PP + PP E P+
Sbjct: 427 EPQLEAPLNEEMP------LLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLP 480
Query: 1134 DPDQMHSTSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSE---HEVWQTVISPDL 1190
+ + + S S PE S + S P + S +SP E +T +SP
Sbjct: 481 EALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPP 540
Query: 1191 SQVTLSPELSQTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLS 1250
LSP ++ LSP SP LSP + P+SP + +SP + L
Sbjct: 541 EASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLF 600
Query: 1251 LDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQT 1310
++ LSP ++ LSP LSP + +S ++ +SP LSP +
Sbjct: 601 PPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVS 660
Query: 1311 NLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDL 1370
LSP + P+SP + S + LSP + SP P SP P + +SL L
Sbjct: 661 RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPL 720
Query: 1371 SQTNL-----SPELSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLG--------- 1416
++ L P+L + P LS P LS P P L P L
Sbjct: 721 EESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLC 780
Query: 1417 ----ETDLSPNFGQMSLSPDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQS 1472
E LSP LSP ++ LSP + L P + P ++ +S +
Sbjct: 781 AVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEP 840
Query: 1473 LLLQEFNESFPYPDLGQMPSPSSP 1496
L ES P+L + P P
Sbjct: 841 CLSPRPEESHLSPELEKPPLSPRP 864
Score = 108 bits (271), Expect = 4e-23
Identities = 96/322 (29%), Positives = 149/322 (46%), Gaps = 19/322 (5%)
Query: 1183 QTVISPDLSQVTLSPELSQTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSP 1242
++ +SP + SP + LSP SP +LS L + P+SP + LSP
Sbjct: 446 ESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSP 505
Query: 1243 DLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMT 1302
+ S L ++ LSP ++ SPAL + PLSP + LS F ++ LSP +
Sbjct: 506 PPESSPFS-PLEESPLSPP-EESPPSPAL-ETPLSPPPEASPLSPPFEESPLSPPPEELP 562
Query: 1303 LSPELSQTNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPS 1362
SP + LSP + P+SP + +S + L P ++ LSP + PLSP P
Sbjct: 563 TSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPE 622
Query: 1363 HTTLSLDLSQTNLSPELSQTNLSPDLSEMPLFADLSQIP----LTPDLDQMTLSPDLGET 1418
+ LS + +SP ++ +SP P + LS +P L+P ++ LSP E+
Sbjct: 623 ASRLSPPPEDSPMSPPPEESPMSPP----PEVSRLSPLPVVSRLSPPPEESPLSPPPEES 678
Query: 1419 DLSPNFGQMSLSPDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEF 1478
SP P+ S+++ P+ S T+ P+ S SPPP+ + P E S L L E
Sbjct: 679 PTSP-------PPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEE 731
Query: 1479 NESFPYPDLGQM-PSPSSPTLN 1499
+ P + + P P P L+
Sbjct: 732 PQLCPRSEGPHLSPRPEEPHLS 753
Score = 76.6 bits (187), Expect = 2e-13
Identities = 69/241 (28%), Positives = 104/241 (43%), Gaps = 21/241 (8%)
Query: 1258 LSPELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQTNLSPALG 1317
L P+L +P +MPL P + LS PE S + PE S+ LSP
Sbjct: 426 LEPQLE----APLNEEMPLLPPPEESPLSPP-------PEESPTSPPPEASR--LSPPPE 472
Query: 1318 QMPISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSP------DPSHTTLSLDLS 1371
++P SP LS ++ LSP ++ LSP P SP P +
Sbjct: 473 ELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPAL 532
Query: 1372 QTNLSPELSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSP 1431
+T LSP + LSP E PL ++P +P + LSP E+ +SP + +SP
Sbjct: 533 ETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSP 592
Query: 1432 DLSQVTLSPDISDTTLL--PDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQ 1489
L P ++ L P+ S +SPPP+ ++ P E S E + P P++ +
Sbjct: 593 PPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSR 652
Query: 1490 M 1490
+
Sbjct: 653 L 653
Score = 76.6 bits (187), Expect = 2e-13
Identities = 73/269 (27%), Positives = 118/269 (43%), Gaps = 17/269 (6%)
Query: 1295 SPELSHMTLSPELSQTNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQ 1354
+P M L P ++ LSP + P SP + LS + SP +LS L +
Sbjct: 432 APLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEE 491
Query: 1355 MPLSPDPSHTTLSLDLSQTNLSPELSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPD 1414
PLSP P + LS + SP L ++ LSP P + + PL+P + LSP
Sbjct: 492 SPLSPPPEESPLSPPPESSPFSP-LEESPLSPPEESPP--SPALETPLSPPPEASPLSPP 548
Query: 1415 LGETDLSPNFGQMSLS--PDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQS 1472
E+ LSP ++ S P+ S+++ P+ S + P+ S +SPPP+ ++F P E S
Sbjct: 549 FEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPL 608
Query: 1473 LLLQEFNESFPYPDLGQM-----PSPSSPTLNDTFLS-----KEFNPLVIVGLSKDGTDY 1522
E + P P+ ++ SP SP ++ +S +PL +V +
Sbjct: 609 SPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEE 668
Query: 1523 IEII--PKEEVQSSEDDYAEIDYVPYDDP 1549
+ P+E S + + + P D P
Sbjct: 669 SPLSPPPEESPTSPPPEASRLSPPPEDSP 697
>gi|10835083 X-linked juvenile retinoschisis protein precursor [Homo
sapiens]
Length = 224
Score = 110 bits (274), Expect = 2e-23
Identities = 60/155 (38%), Positives = 97/155 (62%), Gaps = 5/155 (3%)
Query: 2069 PLGMENGKIENKQITASSFKKS-WWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDL 2127
PLG E+G++ QIT S+ ++ W W +ARLN+QG AW +K ++ QWL+IDL
Sbjct: 68 PLGFESGEVTPDQITCSNPEQYVGWYSSWTANKARLNSQGFGCAWLSKFQDSSQWLQIDL 127
Query: 2128 LKIKKITAIITQGCKSLSSEMYVKSYTIHY-SEQGVEWKPYRLKSSMVDKIFEGNTNTKG 2186
+IK I+ I+TQG + ++ Y++ Y +++ + W Y+ ++ +++F GN++
Sbjct: 128 KEIKVISGILTQGRCDIDE--WMTKYSVQYRTDERLNWIYYKDQTGN-NRVFYGNSDRTS 184
Query: 2187 HVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGC 2221
V+N PPIISRFIR+IP W+ IA+R+EL C
Sbjct: 185 TVQNLLRPPIISRFIRLIPLGWHVRIAIRMELLEC 219
Score = 80.1 bits (196), Expect = 2e-14
Identities = 54/165 (32%), Positives = 93/165 (56%), Gaps = 15/165 (9%)
Query: 1910 PMGLSTGIISDSQIKAS---EFLGY---WEPRLARLNNGGSYNAWSVEKLAAEFASKPWI 1963
P+G +G ++ QI S +++G+ W ARLN+ G AW L+ S W+
Sbjct: 68 PLGFESGEVTPDQITCSNPEQYVGWYSSWTANKARLNSQGFGCAW----LSKFQDSSQWL 123
Query: 1964 QVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQ-INWQIFKGNSTRNVMYFNGNS 2022
Q+D+++ +I+GI TQG + + T++ V Y +++ +NW +K + T N F GNS
Sbjct: 124 QIDLKEIKVISGILTQGRCDIDE--WMTKYSVQYRTDERLNWIYYK-DQTGNNRVFYGNS 180
Query: 2023 DASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCS 2067
D ++ +N PPI++R+IR+ P + R +R+EL C V+ C+
Sbjct: 181 DRTSTVQNLLRPPIISRFIRLIPLGWHVRIAIRMELLEC-VSKCA 224
>gi|223005864 carboxypeptidase X (M14 family), member 2 [Homo sapiens]
Length = 756
Score = 98.6 bits (244), Expect = 6e-20
Identities = 60/171 (35%), Positives = 93/171 (54%), Gaps = 15/171 (8%)
Query: 2062 EVNGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVN-------AWQA 2114
+V PLG+E KI + Q+ AS+ K+ G + R RLN Q +N AW A
Sbjct: 131 DVRESCPPLGLETLKITDFQLHASTVKRYGLGAH----RGRLNIQAGINENDFYDGAWCA 186
Query: 2115 KANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMV 2174
N+ +QW+E+D ++ + T +ITQG SL +V SY + S W +K+
Sbjct: 187 GRNDLQQWIEVDARRLTRFTGVITQGRNSLWLSDWVTSYKVMVSNDSHTW--VTVKNGSG 244
Query: 2175 DKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTW--NQSIALRLELFGCDI 2223
D IFEGN+ + V N P+++R+IR+ P++W N SI +R+E+ GC +
Sbjct: 245 DMIFEGNSEKEIPVLNELPVPMVARYIRINPQSWFDNGSICMRMEILGCPL 295
Score = 68.2 bits (165), Expect = 9e-11
Identities = 55/167 (32%), Positives = 80/167 (47%), Gaps = 16/167 (9%)
Query: 1905 RDCRMPMGLSTGIISDSQIKASEF----LGYWEPRL---ARLNNGGSYN-AWSVEKLAAE 1956
R+ P+GL T I+D Q+ AS LG RL A +N Y+ AW A
Sbjct: 133 RESCPPLGLETLKITDFQLHASTVKRYGLGAHRGRLNIQAGINENDFYDGAWC----AGR 188
Query: 1957 FASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVM 2016
+ WI+VD ++ TG+ TQG S + T + V S++ W K S M
Sbjct: 189 NDLQQWIEVDARRLTRFTGVITQGRNSLWLSDWVTSYKVMVSNDSHTWVTVKNGS--GDM 246
Query: 2017 YFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPT--LRLELQGC 2061
F GNS+ N+ P+VARYIRI+P ++ + +R+E+ GC
Sbjct: 247 IFEGNSEKEIPVLNELPVPMVARYIRINPQSWFDNGSICMRMEILGC 293
>gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo
sapiens]
Length = 1158
Score = 93.2 bits (230), Expect = 3e-18
Identities = 53/162 (32%), Positives = 83/162 (51%), Gaps = 13/162 (8%)
Query: 2069 PLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVN-------AWQAKANNNKQ 2121
P+GME+ +IE+ QI ASS + G R RLN Q AW A+ + Q
Sbjct: 387 PIGMESHRIEDNQIRASSMLRHGLGAQ----RGRLNMQTGATEDDYYDGAWCAEDDARTQ 442
Query: 2122 WLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGN 2181
W+E+D + + T +ITQG S + +V ++ + +S W Y + + F GN
Sbjct: 443 WIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYT--NGYEEMTFHGN 500
Query: 2182 TNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
+ V + P+++RFIR+ P TWN S+ +RLE+ GC +
Sbjct: 501 VDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSV 542
Score = 74.7 bits (182), Expect = 9e-13
Identities = 48/158 (30%), Positives = 75/158 (47%), Gaps = 6/158 (3%)
Query: 1910 PMGLSTGIISDSQIKASEFL----GYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQV 1965
P+G+ + I D+QI+AS L G RL + + A + A WI+V
Sbjct: 387 PIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEV 446
Query: 1966 DMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDAS 2025
D ++ TG+ TQG + + T F+V +S++ W ++ M F+GN D
Sbjct: 447 DTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEE--MTFHGNVDKD 504
Query: 2026 TIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEV 2063
T ++ P+VAR+IRI P +RLE+ GC V
Sbjct: 505 TPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSV 542
>gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapiens]
Length = 1331
Score = 92.0 bits (227), Expect = 6e-18
Identities = 52/143 (36%), Positives = 79/143 (55%), Gaps = 7/143 (4%)
Query: 2084 ASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKS 2143
A S S G Y P A++N +G W +++ QWL++D K+I+AI TQG
Sbjct: 47 AFSSSSSISGSY-SPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQG--R 103
Query: 2144 LSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRV 2203
SS +V Y + YS+ G WKPY ++ F GN N+ G V++ PII+R++R+
Sbjct: 104 YSSSDWVTQYRMLYSDTGRNWKPYHQDGNI--WAFPGNINSDGVVRHELQHPIIARYVRI 161
Query: 2204 IPKTWNQS--IALRLELFGCDIY 2224
+P WN I LR+E++GC +
Sbjct: 162 VPLDWNGEGRIGLRIEVYGCSYW 184
Score = 68.2 bits (165), Expect = 9e-11
Identities = 50/177 (28%), Positives = 79/177 (44%), Gaps = 19/177 (10%)
Query: 1925 ASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHY 1984
+S G + P A++N G WS ++ W+QVD I+ I TQG Y
Sbjct: 51 SSSISGSYSPGYAKINKRGGAGGWS----PSDSDHYQWLQVDFGNRKQISAIATQG--RY 104
Query: 1985 LKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRIS 2044
S + T++ + YS NW+ + + N+ F GN ++ + ++ PI+ARY+RI
Sbjct: 105 SSSDWVTQYRMLYSDTGRNWKPYHQDG--NIWAFPGNINSDGVVRHELQHPIIARYVRIV 162
Query: 2045 PT--RAYNRPTLRLELQGCEV--------NGCSTPLGMENGKIEN-KQITASSFKKS 2090
P R LR+E+ GC P N K++ K + A +FK S
Sbjct: 163 PLDWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRFRNKKMKTLKDVIALNFKTS 219
>gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sapiens]
Length = 1235
Score = 86.3 bits (212), Expect = 3e-16
Identities = 49/126 (38%), Positives = 67/126 (53%), Gaps = 6/126 (4%)
Query: 2098 PFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHY 2157
P ARLN + W +N QWL+IDL + ++TA+ TQG S +V SY + +
Sbjct: 31 PGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMF 88
Query: 2158 SEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQS--IALR 2215
S+ G WK YR + S+ F GN N V P I +RF+R IP WN I +R
Sbjct: 89 SDSGWNWKQYRQEDSIWG--FSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMR 146
Query: 2216 LELFGC 2221
+E+FGC
Sbjct: 147 IEVFGC 152
Score = 58.5 bits (140), Expect = 7e-08
Identities = 43/158 (27%), Positives = 75/158 (47%), Gaps = 12/158 (7%)
Query: 1906 DCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQV 1965
DC P L + + S +SE P ARLN WS L + W+Q+
Sbjct: 5 DCDDP--LVSALPQASFSSSSELSSSHGPGFARLNRRDGAGGWS--PLVSN--KYQWLQI 58
Query: 1966 DMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDAS 2025
D+ + + +T + TQG Y S + T + + +S + NW+ ++ + + F+GN++A
Sbjct: 59 DLGERMEVTAVATQGG--YGSSNWVTSYLLMFSDSGWNWKQYRQEDS--IWGFSGNANAD 114
Query: 2026 TIKENQFDPPIVARYIRISPT--RAYNRPTLRLELQGC 2061
++ + P I AR++R P R +R+E+ GC
Sbjct: 115 SVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGC 152
>gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sapiens]
Length = 1308
Score = 86.3 bits (212), Expect = 3e-16
Identities = 49/126 (38%), Positives = 67/126 (53%), Gaps = 6/126 (4%)
Query: 2098 PFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHY 2157
P ARLN + W +N QWL+IDL + ++TA+ TQG S +V SY + +
Sbjct: 56 PGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMF 113
Query: 2158 SEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQS--IALR 2215
S+ G WK YR + S+ F GN N V P I +RF+R IP WN I +R
Sbjct: 114 SDSGWNWKQYRQEDSIWG--FSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMR 171
Query: 2216 LELFGC 2221
+E+FGC
Sbjct: 172 IEVFGC 177
Score = 58.5 bits (140), Expect = 7e-08
Identities = 43/158 (27%), Positives = 75/158 (47%), Gaps = 12/158 (7%)
Query: 1906 DCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQV 1965
DC P L + + S +SE P ARLN WS L + W+Q+
Sbjct: 30 DCDDP--LVSALPQASFSSSSELSSSHGPGFARLNRRDGAGGWS--PLVSN--KYQWLQI 83
Query: 1966 DMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDAS 2025
D+ + + +T + TQG Y S + T + + +S + NW+ ++ + + F+GN++A
Sbjct: 84 DLGERMEVTAVATQGG--YGSSNWVTSYLLMFSDSGWNWKQYRQEDS--IWGFSGNANAD 139
Query: 2026 TIKENQFDPPIVARYIRISPT--RAYNRPTLRLELQGC 2061
++ + P I AR++R P R +R+E+ GC
Sbjct: 140 SVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGC 177
>gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2
[Homo sapiens]
Length = 1207
Score = 85.9 bits (211), Expect = 4e-16
Identities = 54/158 (34%), Positives = 79/158 (50%), Gaps = 13/158 (8%)
Query: 2066 CSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEI 2125
C +PL + ++SS S G P +RLN + W +N QWL+I
Sbjct: 31 CDSPLA---SALPRSSFSSSSELSSSHG----PGFSRLNRRDGAGGWTPLVSNKYQWLQI 83
Query: 2126 DLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTK 2185
DL + ++TA+ TQG S +V SY + +S+ G WK YR + S+ F GNTN
Sbjct: 84 DLGERMEVTAVATQG--GYGSSDWVTSYLLMFSDGGRNWKQYRREESIWG--FPGNTNAD 139
Query: 2186 GHVKNFFNPPIISRFIRVIPKTWNQ--SIALRLELFGC 2221
V PP +RF+R +P WN I +R+E++GC
Sbjct: 140 SVVHYRLQPPFEARFLRFLPLAWNPRGRIGMRIEVYGC 177
Score = 60.8 bits (146), Expect = 1e-08
Identities = 43/159 (27%), Positives = 77/159 (48%), Gaps = 14/159 (8%)
Query: 1906 DCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQV 1965
DC P L++ + S +SE P +RLN W+ L + W+Q+
Sbjct: 30 DCDSP--LASALPRSSFSSSSELSSSHGPGFSRLNRRDGAGGWT--PLVSN--KYQWLQI 83
Query: 1966 DMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDAS 2025
D+ + + +T + TQG Y S + T + + +S NW+ ++ + + F GN++A
Sbjct: 84 DLGERMEVTAVATQGG--YGSSDWVTSYLLMFSDGGRNWKQYRREES--IWGFPGNTNAD 139
Query: 2026 TIKENQFDPPIVARYIRISPTRAYN---RPTLRLELQGC 2061
++ + PP AR++R P A+N R +R+E+ GC
Sbjct: 140 SVVHYRLQPPFEARFLRFLPL-AWNPRGRIGMRIEVYGC 177
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,621,272
Number of Sequences: 37866
Number of extensions: 4540575
Number of successful extensions: 11581
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 216
Number of HSP's that attempted gapping in prelim test: 9932
Number of HSP's gapped (non-prelim): 927
length of query: 2224
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2106
effective length of database: 13,779,330
effective search space: 29019268980
effective search space used: 29019268980
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.