Search of human proteins with 112382270

Search of human proteins with 112382270

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
sapiens]
         (603 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...  1275   0.0  
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   511   e-145
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   385   e-107
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   361   1e-99
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   361   1e-99
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   358   1e-98
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    283   4e-76
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   280   3e-75
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   262   8e-70
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   245   1e-64
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   244   2e-64
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   241   1e-63
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   239   5e-63
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    237   2e-62
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   234   2e-61
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   233   5e-61
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      232   6e-61
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   216   4e-56
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                214   2e-55
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      181   2e-45
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   181   2e-45
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   170   3e-42
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    158   1e-38
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   138   1e-32
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   120   4e-27
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]      110   5e-24
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    82   1e-15
gi|11321561 hemopexin precursor [Homo sapiens]                         70   4e-12
gi|88853069 vitronectin precursor [Homo sapiens]                       66   8e-11
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]           55   2e-07

>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score = 1275 bits (3299), Expect = 0.0
 Identities = 603/603 (100%), Positives = 603/603 (100%)

Query: 1   MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFG 60
           MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFG
Sbjct: 1   MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFG 60

Query: 61  YLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQ 120
           YLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQ
Sbjct: 61  YLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQ 120

Query: 121 ARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAG 180
           ARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAG
Sbjct: 121 ARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAG 180

Query: 181 SAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGM 240
           SAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGM
Sbjct: 181 SAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGM 240

Query: 241 DLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESV 300
           DLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESV
Sbjct: 241 DLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESV 300

Query: 301 SPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRD 360
           SPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRD
Sbjct: 301 SPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRD 360

Query: 361 RHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRP 420
           RHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRP
Sbjct: 361 RHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRP 420

Query: 421 VSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLD 480
           VSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLD
Sbjct: 421 VSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLD 480

Query: 481 DAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAE 540
           DAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAE
Sbjct: 481 DAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAE 540

Query: 541 GPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQA 600
           GPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQA
Sbjct: 541 GPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQA 600

Query: 601 LTL 603
           LTL
Sbjct: 601 LTL 603


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  511 bits (1317), Expect = e-145
 Identities = 274/581 (47%), Positives = 347/581 (59%), Gaps = 34/581 (5%)

Query: 20  RLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELS 79
           RL L  LLLL L       A AP P A+D+SLGV+WL+R+GYLPP  P   QLQ+ E+L 
Sbjct: 4   RLRLLALLLLLLAP----PARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLR 59

Query: 80  KAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQA--RRRRQAPAPTKWNKRN 137
            AI  MQ+F GL  TG +D  T+A M+ PRCSLPD+  +     RRRR A + + W KR 
Sbjct: 60  DAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRT 119

Query: 138 LSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEV---AGSAADIQIDFSKADH 194
           L+WRVR+FP+ S L  +TVR LM YAL  W   + L FHEV    G   DI IDF++A H
Sbjct: 120 LTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFH 179

Query: 195 NDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAI 254
            D YPFDG GGT+AHAFFPG H  +GDTHFDD+E WTF S D  G DLFAVAVHEFGHA+
Sbjct: 180 QDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHAL 239

Query: 255 GLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPE 314
           GL H +A +SIMRP+YQGPVGDP +Y L  +D+  + QLYG +   +P  +P   PL P 
Sbjct: 240 GLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYG-KAPQTPYDKPTRKPLAPP 298

Query: 315 P-PDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHR 373
           P P    +  P   +P RC  +FDA+A IRGE FFFKG +FWRL     LVS +PA++HR
Sbjct: 299 PQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHR 358

Query: 374 FWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPG-GID 432
           FW GLP  +  V A Y R  D +I+ F G ++WVF+D  +E G  RP+++  LPPG  +D
Sbjct: 359 FWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELGLPPGEEVD 417

Query: 433 AAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYF 492
           A FSW  N +TY  + + YWRYD+     DPGYP    LW G P + DD    + G +YF
Sbjct: 418 AVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYF 477

Query: 493 FRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAEGPRAPPGQHDQS 552
           F+G  YW+     ++  P  PQ    +WL C       + ++G  A   P+A P      
Sbjct: 478 FKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC------PAPSSGPRAPRPPKATPVS---- 527

Query: 553 RSEDGYEVCSCTSGASSPPGA-PGPLVAATMLLLLPPLSPG 592
                 E C C    +   G  P P+     LLLLP L  G
Sbjct: 528 ------ETCDCQCELNQAAGRWPAPI----PLLLLPLLVGG 558


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  385 bits (989), Expect = e-107
 Identities = 227/580 (39%), Positives = 308/580 (53%), Gaps = 66/580 (11%)

Query: 4   RAARGPGPPPPGPGLS------RLPLPLLLLL------------------ALGTRGGCA- 38
           RAA GP PPPP PG +      R+P  LLLLL                    G R   A 
Sbjct: 8   RAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAGNRAAVAV 67

Query: 39  APAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILD 98
           A A A  AE    G  WL  +GYL P D     L + + L  A++ MQQF G+  TG+LD
Sbjct: 68  AVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLD 127

Query: 99  EATLALMKTPRCSLPDLPVLTQARR-RRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVR 157
           + T+  MK PRC +PD P L++ RR +R A    KW ++++++ +  +     +G    R
Sbjct: 128 QTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNY--TPKVGELDTR 185

Query: 158 ALMYYALKVWSDIAPLNFHEVA-------GSAADIQIDFSKADHNDGYPFDGPGGTVAHA 210
             +  A  VW  + PL F EV           ADI I F+   H D  PFDG GG +AHA
Sbjct: 186 KAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHA 245

Query: 211 FFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYY 270
           +FPG     GDTHFD DE WT  +++  G DLF VAVHE GHA+GL H +   +IM P+Y
Sbjct: 246 YFPG-PGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFY 304

Query: 271 QGPVGDPLRYGLPYEDKVRVWQLYG----------------VRESVSPTAQP-EEPPLLP 313
           Q    +   + LP +D   + ++YG                VR   SP+ +  E  P  P
Sbjct: 305 Q--YMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPP 362

Query: 314 EPP-DNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMH 372
            PP  +R S P  K  P+ C  +F+ VA  RGE F FK ++FWRL R+  +    P Q+ 
Sbjct: 363 RPPLGDRPSTPGTK--PNICDGNFNTVALFRGEMFVFKDRWFWRL-RNNRVQEGYPMQIE 419

Query: 373 RFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFS--LPPGG 430
           +FW+GLP     +DA YER +D + VFFKGD+YWVFK+  VE GYP  + +    LP  G
Sbjct: 420 QFWKGLPAR---IDAAYER-ADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREG 475

Query: 431 IDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDG-A 489
           ID A  W    +TYFFK + YWRY +  R  DPGYP    +W+G+P     A    +G  
Sbjct: 476 IDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYY 535

Query: 490 SYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQAD 529
           +YF++G++YWK  + +L V PGYP++  RDW+ C   + +
Sbjct: 536 TYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVE 575


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  361 bits (926), Expect = 1e-99
 Identities = 208/535 (38%), Positives = 295/535 (55%), Gaps = 49/535 (9%)

Query: 9   PGPPPPGPGLSRLPLPLLLL-LALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADP 67
           P P PP      L LPLL L  AL + G   + + +P A        WL ++GYLPP D 
Sbjct: 3   PAPRPP----RCLLLPLLTLGTALASLGSAQSSSFSPEA--------WLQQYGYLPPGDL 50

Query: 68  TTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPD---LPVLTQARRR 124
            T   ++ + LS AI AMQ+F GL+ TG  D  T+  M+ PRC +PD     +    RR+
Sbjct: 51  RTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRK 110

Query: 125 RQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGS--- 181
           R A    KW    +++ ++ +     +G       +  A +VW    PL F EV  +   
Sbjct: 111 RYAIQGLKWQHNEITFCIQNYT--PKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIR 168

Query: 182 -----AADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSD 236
                 ADI I F++  H D  PFDG GG +AHA+FPG +   GDTHFD  E WT R+ D
Sbjct: 169 EGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPN-IGGDTHFDSAEPWTVRNED 227

Query: 237 AHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGV 296
            +G D+F VAVHE GHA+GL H +   +IM P+YQ    D   + LP +D+  + QLYG 
Sbjct: 228 LNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWM--DTENFVLPDDDRRGIQQLYG- 284

Query: 297 RESVSPTAQPEEP-----PLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKG 351
            ES  PT  P +P     P +P+ P N +        P+ C  +FD VA +RGE F FK 
Sbjct: 285 GESGFPTKMPPQPRTTSRPSVPDKPKNPTYG------PNICDGNFDTVAMLRGEMFVFKE 338

Query: 352 KYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDN 411
           ++FWR+ R+  ++   P  + +FWRGLP    S++  YER  D K VFFKGD++WVF + 
Sbjct: 339 RWFWRV-RNNQVMDGYPMPIGQFWRGLPA---SINTAYER-KDGKFVFFKGDKHWVFDEA 393

Query: 412 NVEEGYPRPVSDF--SLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQS 469
           ++E GYP+ + +    LP   IDAA  W  N +TYFF+   Y+R+++  R +D  YP   
Sbjct: 394 SLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI 453

Query: 470 PLWRGVPSTLDDAMRWSDGA-SYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVC 523
            +W G+P +   +   SD   +YF++G +YWK  + +L+V PGYP+S  RDW+ C
Sbjct: 454 KVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC 508


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  361 bits (926), Expect = 1e-99
 Identities = 218/580 (37%), Positives = 301/580 (51%), Gaps = 78/580 (13%)

Query: 23  LPLLLLLALGTRGGCAAPAPAPRAEDLSLGVE-WLSRFGYLPPADPTTGQLQTQEELSKA 81
           LPLLL+L      GC     A  AED  +  E WL  +GYLP        +++ + L+ A
Sbjct: 30  LPLLLVLL-----GCLGLGVA--AEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASA 82

Query: 82  ITAMQQFGGLEATGILDEATLALMKTPRCSLPD---LPVLTQARRRRQAPAPT--KWNKR 136
           +  MQ+F G+  TG+LDE T   MK PRC +PD   + V    RRRR+  A T  KWN  
Sbjct: 83  LAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNH 142

Query: 137 NLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVA--------GSAADIQID 188
           +L++ ++ +     LG       +  A +VW    PL F EV            ADI + 
Sbjct: 143 HLTFSIQNYTEK--LGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVL 200

Query: 189 FSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVH 248
           F+   H D  PFDG GG +AHA+FPG     GDTHFD DE WTF S+D HG +LF VAVH
Sbjct: 201 FASGFHGDSSPFDGTGGFLAHAYFPGPG-LGGDTHFDADEPWTFSSTDLHGNNLFLVAVH 259

Query: 249 EFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVS------P 302
           E GHA+GL H +  ++IM P+YQ    D   + LP +D   + QLYG  +         P
Sbjct: 260 ELGHALGLEHSSNPNAIMAPFYQWK--DVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLP 317

Query: 303 TAQPEEP---------PLLPEPPDNRSSAPPRKDV--------------PHRCSTHFDAV 339
           T  P  P         P  P PP  +   PP+                 P+ C   FD V
Sbjct: 318 TVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTV 377

Query: 340 AQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVF 399
           A +RGE F FKG++FWR+  +R ++   P  +  FWRGLP     + A YER  D + VF
Sbjct: 378 AMLRGEMFVFKGRWFWRVRHNR-VLDNYPMPIGHFWRGLP---GDISAAYER-QDGRFVF 432

Query: 400 FKGDRYWVFKDNNVEEGYPRPVSDFSL--PPGGIDAAFSWAHNDRTYFFKDQLYWRYDDH 457
           FKGDRYW+F++ N+E GYP+P++ + L  P   ID A  W     T+FF++  YWR+++ 
Sbjct: 433 FKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEE 492

Query: 458 TRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGA-SYFFRGQEYWKVLDGELEVAPGYPQST 516
           T+  DPGYP    +W+G+P++   A   +D A +YF++G +YWK  +  L + PGYP+S 
Sbjct: 493 TQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSI 552

Query: 517 ARDWLVCGDS---------------QADGSVAAGVDAAEG 541
            RD++ C +                   G    G D+AEG
Sbjct: 553 LRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEG 592


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  358 bits (918), Expect = 1e-98
 Identities = 196/499 (39%), Positives = 274/499 (54%), Gaps = 42/499 (8%)

Query: 55  WLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPD 114
           WL ++GYLPP DP    L++ E +  A+ AMQQF G+  TG +D  T+  MK PRC +PD
Sbjct: 46  WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105

Query: 115 L---PVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIA 171
                     RR+R A    KW  +++++ ++       +G    R  +  A  VW ++ 
Sbjct: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNV--TPKVGDPETRKAIRRAFDVWQNVT 163

Query: 172 PLNFHEVAGSA-------ADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHF 224
           PL F EV  S         DI I F+   H D  PFDG GG +AHA+FPG     GDTHF
Sbjct: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPG-PGIGGDTHF 222

Query: 225 DDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPY 284
           D DE WT  + +  G DLF VAVHE GHA+GL H     +IM P+YQ    D   + LP 
Sbjct: 223 DSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETD--NFKLPN 280

Query: 285 EDKVRVWQLYGVRESVSPTAQP-----------------EEPPLLPEPPDNRSSAPPRKD 327
           +D   + ++YG  + + P  +P                  + P  P PP  R S P  K 
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAK- 339

Query: 328 VPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDA 387
            P+ C  +F+ +A +R E F FK ++FWR+ R+  ++   P Q+  FWRGLP    S+DA
Sbjct: 340 -PNICDGNFNTLAILRREMFVFKDQWFWRV-RNNRVMDGYPMQITYFWRGLP---PSIDA 394

Query: 388 VYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDF--SLPPGGIDAAFSWAHNDRTYF 445
           VYE  SD   VFFKG++YWVFKD  ++ GYP  +      +PP GID+A  W    +TYF
Sbjct: 395 VYE-NSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYF 453

Query: 446 FKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDA-MRWSDGASYFFRGQEYWKVLDG 504
           FK   YWRY +  + MDPGYP    +W+G+P +   A +   +G +YF++G+EYWK  + 
Sbjct: 454 FKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQ 513

Query: 505 ELEVAPGYPQSTARDWLVC 523
            L+V PGYP+S  +D++ C
Sbjct: 514 ILKVEPGYPRSILKDFMGC 532


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  283 bits (723), Expect = 4e-76
 Identities = 190/519 (36%), Positives = 258/519 (49%), Gaps = 63/519 (12%)

Query: 23  LPLLLLLALGTRGGCAAPA--PAPRAEDLSLGV--EWLSRFGYLPPADPTTGQLQTQEEL 78
           LP+LLLL +     C+A     A R ED S+ +  ++L  +  L        + +    +
Sbjct: 4   LPILLLLCVAV---CSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60

Query: 79  SKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNL 138
            K I  MQ+F GLE TG LD  TL +M+ PRC +PD+         R  P   KW K +L
Sbjct: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHF------RTFPGIPKWRKTHL 114

Query: 139 SWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGY 198
           ++R+  +  D P   D V + +  ALKVW ++ PL F  +    ADI I F+  +H D Y
Sbjct: 115 TYRIVNYTPDLP--KDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFY 172

Query: 199 PFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSH 258
           PFDGPG  +AHA+ PG     GD HFDDDE WT    D  G +LF VA HE GH++GL H
Sbjct: 173 PFDGPGNVLAHAYAPG-PGINGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHSLGLFH 228

Query: 259 VAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDN 318
            A   ++M P Y   + D  R+ L  +D   +  LYG      P     E PL+P  P  
Sbjct: 229 SANTEALMYPLYHS-LTDLTRFRLSQDDINGIQSLYG------PPPDSPETPLVPTEP-- 279

Query: 319 RSSAPPRKDVPHRC--STHFDAVAQIRGEAFFFKGKYFWR-----LTRDRHLVSLQPAQM 371
               PP    P  C  +  FDAV+ +RGE   FK ++FWR     L  + HL+S      
Sbjct: 280 ---VPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLIS------ 330

Query: 372 HRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPP--G 429
             FW  LP     VDA YE TS   +  FKG+++W  + N V  GYPR +     PP   
Sbjct: 331 -SFWPSLP---SGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVR 386

Query: 430 GIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDG 488
            IDAA S    ++TYFF +  YWR+D+    M+PG+P Q +  + G+ S + DA+    G
Sbjct: 387 KIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKI-DAVFEEFG 445

Query: 489 ASYFFRGQEYWKVLDGELEVAPGYPQST----ARDWLVC 523
             YFF G         +LE  P   + T    +  WL C
Sbjct: 446 FFYFFTG-------SSQLEFDPNAKKVTHTLKSNSWLNC 477


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  280 bits (716), Expect = 3e-75
 Identities = 172/428 (40%), Positives = 225/428 (52%), Gaps = 27/428 (6%)

Query: 105 MKTPRCSLPDLPVLTQARRRRQ--APAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYY 162
           ++ PRC +PD      AR R++    +  +W K +L++R+  FP    L  + VR  M  
Sbjct: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQ--LVQEQVRQTMAE 132

Query: 163 ALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDT 222
           ALKVWSD+ PL F EV    ADI IDF++  H D  PFDGPGG +AHAFFP   H  GD 
Sbjct: 133 ALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFP-KTHREGDV 191

Query: 223 HFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRY-- 280
           HFD DE WT    D  G DL  VA HEFGH +GL H  AA ++M  +Y        RY  
Sbjct: 192 HFDYDETWTI--GDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFY------TFRYPL 243

Query: 281 GLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPP-DNRSSAPPRKDV-PHRCSTHFDA 338
            L  +D   V  LYG      PT     P L P+   D    AP   D  P  C   FDA
Sbjct: 244 SLSPDDCRGVQHLYG---QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDA 300

Query: 339 VAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIV 398
           V+ IRGE FFFK  + WRL R   L    PA   R W+GLP     VDA +E    H I 
Sbjct: 301 VSTIRGELFFFKAGFVWRL-RGGQLQPGYPALASRHWQGLP---SPVDAAFEDAQGH-IW 355

Query: 399 FFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWA-HNDRTYFFKDQLYWRYDDH 457
           FF+G +YWV+       G P P+++  L    + AA  W    ++ YFF+ + YWR+   
Sbjct: 356 FFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPS 414

Query: 458 TRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTA 517
           TR +D   P ++  WRGVPS +D A + +DG +YF RG+ YWK    +++   G+P+   
Sbjct: 415 TRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVG 474

Query: 518 RDWLVCGD 525
            D+  C +
Sbjct: 475 PDFFGCAE 482


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  262 bits (669), Expect = 8e-70
 Identities = 163/431 (37%), Positives = 228/431 (52%), Gaps = 45/431 (10%)

Query: 80  KAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLS 139
           K I  MQ+F GLE TG LD  TL +M+ PRC +PD+   +        P   KW K +L+
Sbjct: 61  KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSF------PGMPKWRKTHLT 114

Query: 140 WRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYP 199
           +R+  +  D P   D V + +  ALKVW ++ PL F  +    ADI I F+  +H D Y 
Sbjct: 115 YRIVNYTPDLP--RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYS 172

Query: 200 FDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHV 259
           FDGPG ++AHA+ PG     GD HFDDDE WT    DA G +LF VA HE GH++GL H 
Sbjct: 173 FDGPGHSLAHAYPPG-PGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGLFHS 228

Query: 260 AAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNR 319
           A   ++M P Y     +  ++ L  +D   +  LYG      P A  EE PL+P      
Sbjct: 229 ANTEALMYPLYNS-FTELAQFRLSQDDVNGIQSLYG-----PPPASTEE-PLVP-----T 276

Query: 320 SSAPPRKDVPHRC--STHFDAVAQIRGEAFFFKGKYFWRLTR-----DRHLVSLQPAQMH 372
            S P   ++P +C  +  FDA++ +RGE  FFK +YFWR +      + HL+S       
Sbjct: 277 KSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLIS------- 329

Query: 373 RFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPP--GG 430
            FW  LP +L   DA YE  S   +  FKG+ +W  + N V+ GYPR +     PP    
Sbjct: 330 AFWPSLPSYL---DAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRK 386

Query: 431 IDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGA 489
           IDAA S     +TYFF    YWR+D++++ M+ G+P   +  + GV   + DA+  + G 
Sbjct: 387 IDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKV-DAVLQAFGF 445

Query: 490 SYFFRGQEYWK 500
            YFF G   ++
Sbjct: 446 FYFFSGSSQFE 456


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  245 bits (625), Expect = 1e-64
 Identities = 158/455 (34%), Positives = 213/455 (46%), Gaps = 48/455 (10%)

Query: 47  EDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMK 106
           EDL     +L  + Y P       +      +++ +  MQ F GLE TG LD+ TL +MK
Sbjct: 34  EDLQFAERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMK 92

Query: 107 TPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKV 166
            PRC +PD+            P   KW+K NL++R+  +  D  + H  V      A KV
Sbjct: 93  KPRCGVPDVG------EYNVFPRTLKWSKMNLTYRIVNYTPD--MTHSEVEKAFKKAFKV 144

Query: 167 WSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDD 226
           WSD+ PLNF  +    ADI I F   +H D YPFDGP G +AHAF PG ++  GD HFDD
Sbjct: 145 WSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNY-GGDAHFDD 203

Query: 227 DEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYED 286
           DE WT   S + G +LF VA HEFGH++GL H     ++M P Y         + LP +D
Sbjct: 204 DETWT---SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY--TYTGKSHFMLPDDD 258

Query: 287 KVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRC--STHFDAVAQIRG 344
              +  LYG                    P +    P     P +C  S   DA+  +RG
Sbjct: 259 VQGIQSLYG--------------------PGDEDPNPKHPKTPDKCDPSLSLDAITSLRG 298

Query: 345 EAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDR 404
           E   FK ++FWRL   +  V  +      FW  LP   + +DA YE  S   I  F+G +
Sbjct: 299 ETMIFKDRFFWRLHPQQ--VDAELFLTKSFWPELP---NRIDAAYEHPSHDLIFIFRGRK 353

Query: 405 YWVFKDNNVEEGYPRPVSDFSLPP--GGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMD 462
           +W     ++ EGYP+ +S+  LP     I AA  +    +T  F     WRYDD    MD
Sbjct: 354 FWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMD 413

Query: 463 PGYPAQSPLWRGVPSTLD--DAMRWSDGASYFFRG 495
             YP    +    P   D  DA+   +G  YFF G
Sbjct: 414 KDYPRL--IEEDFPGIGDKVDAVYEKNGYIYFFNG 446


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  244 bits (622), Expect = 2e-64
 Identities = 164/496 (33%), Positives = 249/496 (50%), Gaps = 41/496 (8%)

Query: 53  VEWLSRFGYLPPADPTTGQLQTQ-EELSKAITAMQQFGGLEATGILDEATLALMKTPRCS 111
           V++LS++GYL    P  G    + E++++A+ A Q+   L  +G LD+AT A M+ PRC 
Sbjct: 29  VDYLSQYGYLQK--PLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCG 86

Query: 112 LPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIA 171
           L D       ++  +     +W K++L++R+   P  S L   T RA +  A + WS++A
Sbjct: 87  LED----PFNQKTLKYLLLGRWRKKHLTFRILNLP--STLPPHTARAALRQAFQDWSNVA 140

Query: 172 PLNFHEVAGSAADIQIDF-SKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAW 230
           PL F EV   AADI++ F  +        FDGPG  +AHA  P      G  HFD+DE W
Sbjct: 141 PLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHADIP----ELGSVHFDEDEFW 196

Query: 231 TFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRV 290
           T       G++L  +A HE GHA+GL H   + ++M P Y+   G    + L  +D   +
Sbjct: 197 T--EGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYE---GYRPHFKLHPDDVAGI 251

Query: 291 WQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDA-VAQIRGEAFFF 349
             LYG +  V    + EE  L   PP     +P    +P  CS+  DA +   RG+ + F
Sbjct: 252 QALYGKKSPVIRDEEEEETELPTVPPVPTEPSP----MPDPCSSELDAMMLGPRGKTYAF 307

Query: 350 KGKYFWRLTRDRHLVSLQPAQMHR---FWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYW 406
           KG Y W ++         P  + R    W GLP +LD+  AVY   +   I FFKGD+ W
Sbjct: 308 KGDYVWTVS------DSGPGPLFRVSALWEGLPGNLDA--AVYSPRTQW-IHFFKGDKVW 358

Query: 407 VFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYP 466
            + +  +  G+P+ ++        +DAA  W  N + + FK   YW++D+  R     YP
Sbjct: 359 RYINFKMSPGFPKKLNRVE---PNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYP 415

Query: 467 AQ-SPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGD 525
                L+ GVP+    AM W DG  YFF+G+ YW+ L+ +L V  GYP++ + +W+ C  
Sbjct: 416 KPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWR-LNQQLRVEKGYPRNISHNWMHCRP 474

Query: 526 SQADGSVAAGVDAAEG 541
              D + + G     G
Sbjct: 475 RTIDTTPSGGNTTPSG 490


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  241 bits (616), Expect = 1e-63
 Identities = 146/385 (37%), Positives = 200/385 (51%), Gaps = 41/385 (10%)

Query: 55  WLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPD 114
           WL ++GYLPP DP    L++ E +  A+ AMQQF G+  TG +D  T+  MK PRC +PD
Sbjct: 46  WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105

Query: 115 L---PVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIA 171
                     RR+R A    KW  +++++ ++       +G    R  +  A  VW ++ 
Sbjct: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNV--TPKVGDPETRKAIRRAFDVWQNVT 163

Query: 172 PLNFHEVAGSA-------ADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHF 224
           PL F EV  S         DI I F+   H D  PFDG GG +AHA+FPG     GDTHF
Sbjct: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPG-PGIGGDTHF 222

Query: 225 DDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPY 284
           D DE WT  + +  G DLF VAVHE GHA+GL H     +IM P+YQ    D   + LP 
Sbjct: 223 DSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETD--NFKLPN 280

Query: 285 EDKVRVWQLYGVRESVSPTAQP-----------------EEPPLLPEPPDNRSSAPPRKD 327
           +D   + ++YG  + + P  +P                  + P  P PP  R S P  K 
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAK- 339

Query: 328 VPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDA 387
            P+ C  +F+ +A +R E F FK ++FWR+ R+  ++   P Q+  FWRGLP    S+DA
Sbjct: 340 -PNICDGNFNTLAILRREMFVFKDQWFWRV-RNNRVMDGYPMQITYFWRGLP---PSIDA 394

Query: 388 VYERTSDHKIVFF--KGDRYWVFKD 410
           VYE  SD   VFF  KGD   + +D
Sbjct: 395 VYE-NSDGNFVFFKVKGDTLSIIQD 418



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 23/52 (44%), Positives = 32/52 (61%), Gaps = 3/52 (5%)

Query: 444 YFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFR 494
           + FKDQ +WR  ++ R MD GYP Q +  WRG+P ++D     SDG   FF+
Sbjct: 358 FVFKDQWFWRVRNN-RVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  239 bits (610), Expect = 5e-63
 Identities = 167/485 (34%), Positives = 237/485 (48%), Gaps = 52/485 (10%)

Query: 24  PLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAIT 83
           PLLLLL  G            + +D+ L  ++L ++  L        + +    + + + 
Sbjct: 6   PLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLK 65

Query: 84  AMQQFGGLEATGILDEATLALMKTPRCSLPDLP--VLTQARRRRQAPAPTKWNKRNLSWR 141
            MQ+F GL+ TG  D  TL +MK PRC +PD+   VLT+   R        W + +L++R
Sbjct: 66  QMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPR--------WEQTHLTYR 117

Query: 142 VRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFD 201
           +  +  D P     V   +  A ++WS++ PL F +V+   ADI I F + DH D  PFD
Sbjct: 118 IENYTPDLPRAD--VDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFD 175

Query: 202 GPGGTVAHAFFPGHHHTAGDTHFDDDEAWT--FRSSDAHGMDLFAVAVHEFGHAIGLSHV 259
           GPGG +AHAF PG     GD HFD+DE WT  FR  + H      VA HE GH++GLSH 
Sbjct: 176 GPGGNLAHAFQPG-PGIGGDAHFDEDERWTNNFREYNLH-----RVAAHELGHSLGLSHS 229

Query: 260 AAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNR 319
               ++M P Y    GD     L  +D   +  +YG        +Q    P+ P+ P   
Sbjct: 230 TDIGALMYPSYTFS-GD---VQLAQDDIDGIQAIYG-------RSQNPVQPIGPQTPKAC 278

Query: 320 SSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLP 379
            S              FDA+  IRGE  FFK +++ R       V L    +  FW  LP
Sbjct: 279 DS-----------KLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISV--FWPQLP 325

Query: 380 LHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPV-SDFSLP--PGGIDAAFS 436
              + ++A YE     ++ FFKG++YW  +  NV  GYP+ + S F  P     IDAA S
Sbjct: 326 ---NGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALS 382

Query: 437 WAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFRG 495
             +  +TYFF    YWRYD++ R MDPGYP   +  + G+   + DA+   DG  YFF G
Sbjct: 383 EENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV-DAVFMKDGFFYFFHG 441

Query: 496 QEYWK 500
              +K
Sbjct: 442 TRQYK 446


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  237 bits (605), Expect = 2e-62
 Identities = 159/483 (32%), Positives = 237/483 (49%), Gaps = 52/483 (10%)

Query: 23  LPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAI 82
           LP LLLL +         +     + +    ++L +F  LP     + +      + + +
Sbjct: 7   LPFLLLLHVQISKAFPVSSKEKNTKTVQ---DYLEKFYQLPSNQYQSTRKNGTNVIVEKL 63

Query: 83  TAMQQFGGLEATGILDEATLALMKTPRCSLPDLP--VLTQARRRRQAPAPTKWNKRNLSW 140
             MQ+F GL  TG  +E TL +MK PRC +PD    +LT        P   KW + NL++
Sbjct: 64  KEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLT--------PGNPKWERTNLTY 115

Query: 141 RVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPF 200
           R+R +     L    V   +  A ++WS  +PL F  ++   ADI I F + DH D  PF
Sbjct: 116 RIRNYTPQ--LSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPF 173

Query: 201 DGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVA 260
           DGP G +AHAF PG     GD HFD +E WT  S++    +LF VA HEFGH++GL+H +
Sbjct: 174 DGPNGILAHAFQPG-QGIGGDAHFDAEETWTNTSAN---YNLFLVAAHEFGHSLGLAHSS 229

Query: 261 AAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRES-VSPTAQPEEPPLLPEPPDNR 319
              ++M P Y     +   Y LP +D   +  +YG+  + + PT      P  P+P D  
Sbjct: 230 DPGALMYPNY--AFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTG-----PSTPKPCDP- 281

Query: 320 SSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLP 379
                        S  FDA+  +RGE  FFK +YFWR  R   L  ++   +  FW  LP
Sbjct: 282 -------------SLTFDAITTLRGEILFFKDRYFWR--RHPQLQRVEMNFISLFWPSLP 326

Query: 380 LHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPG--GIDAAFSW 437
                + A YE      I  FKG++YW     ++ +GYP+ +S++  P     IDAA   
Sbjct: 327 ---TGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAV-- 381

Query: 438 AHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFRGQ 496
            +  +TYFF +  +WRYD+  + M+PGYP   S  + G+ S + DA+   +   + F G 
Sbjct: 382 FYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKV-DAVFQQEHFFHVFSGP 440

Query: 497 EYW 499
            Y+
Sbjct: 441 RYY 443


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  234 bits (596), Expect = 2e-61
 Identities = 169/510 (33%), Positives = 244/510 (47%), Gaps = 46/510 (9%)

Query: 25  LLLLLALGTRGGCAAP---APAPRA--EDLSLGVEWLSRFGYLPPADPTTGQLQTQ--EE 77
           L + L +  +   AAP   A +PR    +  L   +L ++ Y        G++  +    
Sbjct: 9   LAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKY-YTNKEGHQIGEMVARGSNS 67

Query: 78  LSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRN 137
           + + I  +Q F GL+ TG LD+ T+ ++K PRC +PD+         R  P   KW K  
Sbjct: 68  MIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVA------NYRLFPGEPKWKKNT 121

Query: 138 LSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDG 197
           L++R+  +     +    V   +  AL+ WS   PL+F  +    ADI I F   DH D 
Sbjct: 122 LTYRISKYTPS--MSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDS 179

Query: 198 YPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLS 257
           YPFDGP GT+AHAF PG     GDTHFD+ E WT      +G +LF VA HEFGHA+GL+
Sbjct: 180 YPFDGPRGTLAHAFAPG-EGLGGDTHFDNAEKWTM---GTNGFNLFTVAAHEFGHALGLA 235

Query: 258 HVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPD 317
           H     ++M P Y+    +P  + LP +D   +  LYG R+           P LP  P 
Sbjct: 236 HSTDPSALMYPTYK--YKNPYGFHLPKDDVKGIQALYGPRKVFL------GKPTLPHAPH 287

Query: 318 NRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHL-VSLQPAQMHRFWR 376
           ++ S P   D     S+ FDAV  +  E   FK + FWR  R  HL   ++P+ +     
Sbjct: 288 HKPSIPDLCD----SSSSFDAVTMLGKELLLFKDRIFWR--RQVHLRTGIRPSTI---TS 338

Query: 377 GLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLP--PGGIDAA 434
             P  + +VDA YE        FFKG  YW+ +   + +G PR + DF  P     IDAA
Sbjct: 339 SFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQM-QGPPRTIYDFGFPRHVQQIDAA 397

Query: 435 FSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQS-PLWRGVPSTLDDAMRWSDGASYFF 493
                  +T FF    Y+ YD+  R M+  YP  +   + GV   +D A+   +G  YFF
Sbjct: 398 VYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVE-LNGYIYFF 456

Query: 494 RGQEYWKVLDGELEVAPGYPQSTARDWLVC 523
            G + +K  D E E      +S++  W+ C
Sbjct: 457 SGPKTYK-YDTEKEDVVSVVKSSS--WIGC 483


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  233 bits (593), Expect = 5e-61
 Identities = 155/484 (32%), Positives = 232/484 (47%), Gaps = 45/484 (9%)

Query: 25  LLLLLALGTRGGCAAPAPAPRAE--DLSLGVEWLSRF-GYLPPADPTTGQLQTQEELSKA 81
           LL+LL   T  G      +   E  ++  G  +L +F G      P T    +   + + 
Sbjct: 4   LLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEK 63

Query: 82  ITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWR 141
           I  MQ F GL+ TG LD +TL +M  PRC +PD+         R+ P    W K  +++R
Sbjct: 64  IQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDV------HHFREMPGGPVWRKHYITYR 117

Query: 142 VRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFD 201
           +  +  D  +  + V   +  A +VWS++ PL F ++    ADI + F++  H D + FD
Sbjct: 118 INNYTPD--MNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFD 175

Query: 202 GPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAA 261
           G GG +AHAF PG     GD HFD+DE WT  S    G +LF  AVHE GH++GL H + 
Sbjct: 176 GKGGILAHAFGPG-SGIGGDAHFDEDEFWTTHSG---GTNLFLTAVHEIGHSLGLGHSSD 231

Query: 262 AHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSS 321
             ++M P Y+    D   + L  +D   +  LYG          P+E   LP P ++   
Sbjct: 232 PKAVMFPTYK--YVDINTFRLSADDIRGIQSLYG---------DPKENQRLPNPDNSE-- 278

Query: 322 APPRKDVPHRCSTH--FDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLP 379
                  P  C  +  FDAV  +  + FFFK ++FW    +R   S+    +   W  LP
Sbjct: 279 -------PALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVN--LISSLWPTLP 329

Query: 380 LHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLP--PGGIDAAFSW 437
                ++A YE  + +++  FK D+YW+  +   E  YP+ +  F  P     IDAA   
Sbjct: 330 ---SGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFN 386

Query: 438 AHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFRGQ 496
               RTYFF D  YWRYD+  + MDPGYP   +  ++G+   +D      +   YFF+G 
Sbjct: 387 PRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGS 446

Query: 497 EYWK 500
             ++
Sbjct: 447 NQFE 450


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  232 bits (592), Expect = 6e-61
 Identities = 156/424 (36%), Positives = 214/424 (50%), Gaps = 52/424 (12%)

Query: 85  MQQFGGLEATGILDEATLALMKTPRCSLPDLP--VLTQARRRRQAPAPTKWNKRNLSWRV 142
           MQ+F GL+ TG  D  TL +MK PRC +PD+   VLT+   R        W + +L++R+
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPR--------WEQTHLTYRI 52

Query: 143 RTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDG 202
             +  D P     V   +  A ++WS++ PL F +V+   ADI I F + DH D  PFDG
Sbjct: 53  ENYTPDLPRAD--VDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDG 110

Query: 203 PGGTVAHAFFPGHHHTAGDTHFDDDEAWT--FRSSDAHGMDLFAVAVHEFGHAIGLSHVA 260
           PGG +AHAF PG     GD HFD+DE WT  FR  + H      VA HE GH++GLSH  
Sbjct: 111 PGGNLAHAFQPG-PGIGGDAHFDEDERWTNNFREYNLH-----RVAAHELGHSLGLSHST 164

Query: 261 AAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRS 320
              ++M P Y    GD     L  +D   +  +YG        +Q    P+ P+ P    
Sbjct: 165 DIGALMYPSYTFS-GD---VQLAQDDIDGIQAIYG-------RSQNPVQPIGPQTPKACD 213

Query: 321 SAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPL 380
           S              FDA+  IRGE  FFK +++ R       V L    +  FW  LP 
Sbjct: 214 S-----------KLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISV--FWPQLP- 259

Query: 381 HLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPV-SDFSLP--PGGIDAAFSW 437
             + ++A YE     ++ FFKG++YW  +  NV  GYP+ + S F  P     IDAA S 
Sbjct: 260 --NGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSE 317

Query: 438 AHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFRGQ 496
            +  +TYFF    YWRYD++ R MDPGYP   +  + G+   + DA+   DG  YFF G 
Sbjct: 318 ENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV-DAVFMKDGFFYFFHGT 376

Query: 497 EYWK 500
             +K
Sbjct: 377 RQYK 380


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  216 bits (551), Expect = 4e-56
 Identities = 158/492 (32%), Positives = 225/492 (45%), Gaps = 43/492 (8%)

Query: 55  WLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPD 114
           +L ++GYL    P   +  T    S AI A Q    L  +G+LD ATL  M  PRC + D
Sbjct: 39  FLEKYGYLNEQVP---KAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTD 95

Query: 115 LPVLT----------------QARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRA 158
                                  R++R A    KW K++LS+R+  +P   P     VR 
Sbjct: 96  TNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLP--EPAVRG 153

Query: 159 LMYYALKVWSDIAPLNFHEV-AGSAADIQIDFSKADHNDGY--PFDGPGGTVAHAFFPGH 215
            +  A ++WS+++ L F E  A   ADI++ F + DHNDG    FDGPGG +AHAF P  
Sbjct: 154 AVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRR 213

Query: 216 HHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVG 275
               G+ HFD DE W+   S   G +LF V  HE GH +GL+H  A  ++M PYY+    
Sbjct: 214 ----GEAHFDQDERWSL--SRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGR 267

Query: 276 DPLRYGLPYEDKVRVWQLYGVRESVSPTAQ-PEEPPLLPEPPDNRSSAPPRKDV--PHRC 332
           D L   L ++D + V  LYG     S   Q P +     E  D+ S    R +   P  C
Sbjct: 268 DAL---LSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYC 324

Query: 333 STHFDAVAQIRGEAFF-FKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYER 391
            + FDA+   R +  + FKG +FW +  D ++   +P Q    W GLP    +++A    
Sbjct: 325 HSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQER--WVGLP---PNIEAAAVS 379

Query: 392 TSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWAHNDRTYFFKDQLY 451
            +D    FFKG R W F+      G P+      LP    DAA  +    R   FK   Y
Sbjct: 380 LNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHP-DAALFFPPLRRLILFKGARY 438

Query: 452 WRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPG 511
           +        ++P YP     W G+P  +  A+   DG+  FFR   YW++   +L+    
Sbjct: 439 YVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTS 498

Query: 512 YPQSTARDWLVC 523
              +T   W+ C
Sbjct: 499 GRWATELPWMGC 510


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  214 bits (544), Expect = 2e-55
 Identities = 152/460 (33%), Positives = 218/460 (47%), Gaps = 48/460 (10%)

Query: 47  EDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMK 106
           E++ L   +L++F  L        Q + +  +   I  MQ F GL  TG LD  TL +MK
Sbjct: 28  ENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMK 87

Query: 107 TPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKV 166
           TPRC +PD+         +       W K NL++R+  +  D  +    V   +   L+V
Sbjct: 88  TPRCGVPDV--------GQYGYTLPGWRKYNLTYRIINYTPD--MARAAVDEAIQEGLEV 137

Query: 167 WSDIAPLNFHEVAGSAADIQIDFSKADHND-GYPFDGPGGTVAHAFFPGHHHTAGDTHFD 225
           WS + PL F +++   ADI I F    H      FDGP G + HAF PG     GDTHFD
Sbjct: 138 WSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPG-PGLGGDTHFD 196

Query: 226 DDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYE 285
           +DE WT    D  G +LF VA HEFGHA+GLSH     ++M P Y     DP +Y L  +
Sbjct: 197 EDENWT---KDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSL--DPRKYPLSQD 251

Query: 286 DKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTH--FDAVAQIR 343
           D   +  +YG          P+EP           + P    +PH C     FDA+   R
Sbjct: 252 DINGIQSIYG--------GLPKEP-----------AKPKEPTIPHACDPDLTFDAITTFR 292

Query: 344 GEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGD 403
            E  FFKG++ WR+  D  +  ++   +  FW  LP  L    A YE   D KI+ FK +
Sbjct: 293 REVMFFKGRHLWRIYYD--ITDVEFELIASFWPSLPADL---QAAYENPRD-KILVFKDE 346

Query: 404 RYWVFKDNNVEEGYPRPVSDFSLP--PGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHM 461
            +W+ +   V   YP+ +     P     IDAA       +TYFF     WR+D+ T+ M
Sbjct: 347 NFWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTM 406

Query: 462 DPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFRGQEYWK 500
           D G+P +    + G+   +D A ++  G  +F RG + ++
Sbjct: 407 DKGFPQRVVKHFPGISIRVDAAFQYK-GFFFFSRGSKQFE 445


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  181 bits (459), Expect = 2e-45
 Identities = 109/309 (35%), Positives = 155/309 (50%), Gaps = 28/309 (9%)

Query: 219 AGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPL 278
           A   ++DDD  W F      G  LF VA HEFGHA+GL H     ++M P Y        
Sbjct: 326 ATTANYDDDRKWGFCPDQ--GYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKN--- 380

Query: 279 RYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDA 338
            + L  +D   + +LYG    +     P  P L P  P+       ++D+       FD 
Sbjct: 381 -FRLSQDDIKGIQELYGASPDIDLGTGPT-PTLGPVTPEIC-----KQDIV------FDG 427

Query: 339 VAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIV 398
           +AQIRGE FFFK ++ WR    R    + P  +  FW  LP   + +DAVYE   + K V
Sbjct: 428 IAQIRGEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELP---EKIDAVYEAPQEEKAV 483

Query: 399 FFKGDRYWVFKDNNVEEGYPRPVSDFSLPPG--GIDAAFSWAHNDRTYFFKDQLYWRYDD 456
           FF G+ YW++  + +E GYP+P++   LPP    +DAAF+W+ N +TY F    +WRY++
Sbjct: 484 FFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNE 543

Query: 457 HTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGA-SYFFRGQEYWKVLDGELEVAPGYPQ 514
             + MDPG+P   +  W  +P  LD  +    G  SYFF+G  Y K+ +  L+       
Sbjct: 544 VKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF--G 601

Query: 515 STARDWLVC 523
           S   DWL C
Sbjct: 602 SIKSDWLGC 610



 Score =  121 bits (303), Expect = 2e-27
 Identities = 64/154 (41%), Positives = 85/154 (55%), Gaps = 9/154 (5%)

Query: 78  LSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRN 137
           L   +  MQ+F GL  TG LD+ T+  M+ PRC  PD+            P   KW+K  
Sbjct: 20  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA------NYNFFPRKPKWDKNQ 73

Query: 138 LSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDG 197
           +++R+  +  D  L  +TV      A +VWSD+ PL F  +    ADI I+F + +H DG
Sbjct: 74  ITYRIIGYTPD--LDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDG 131

Query: 198 YPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWT 231
           YPFDG  G +AHAF PG     GD+HFDDDE WT
Sbjct: 132 YPFDGKDGLLAHAFAPG-TGVGGDSHFDDDELWT 164


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  181 bits (459), Expect = 2e-45
 Identities = 109/309 (35%), Positives = 155/309 (50%), Gaps = 28/309 (9%)

Query: 219 AGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPL 278
           A   ++DDD  W F      G  LF VA HEFGHA+GL H     ++M P Y        
Sbjct: 376 ATTANYDDDRKWGFCPDQ--GYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKN--- 430

Query: 279 RYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDA 338
            + L  +D   + +LYG    +     P  P L P  P+       ++D+       FD 
Sbjct: 431 -FRLSQDDIKGIQELYGASPDIDLGTGPT-PTLGPVTPEIC-----KQDIV------FDG 477

Query: 339 VAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIV 398
           +AQIRGE FFFK ++ WR    R    + P  +  FW  LP   + +DAVYE   + K V
Sbjct: 478 IAQIRGEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELP---EKIDAVYEAPQEEKAV 533

Query: 399 FFKGDRYWVFKDNNVEEGYPRPVSDFSLPPG--GIDAAFSWAHNDRTYFFKDQLYWRYDD 456
           FF G+ YW++  + +E GYP+P++   LPP    +DAAF+W+ N +TY F    +WRY++
Sbjct: 534 FFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNE 593

Query: 457 HTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGA-SYFFRGQEYWKVLDGELEVAPGYPQ 514
             + MDPG+P   +  W  +P  LD  +    G  SYFF+G  Y K+ +  L+       
Sbjct: 594 VKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF--G 651

Query: 515 STARDWLVC 523
           S   DWL C
Sbjct: 652 SIKSDWLGC 660



 Score =  126 bits (317), Expect = 5e-29
 Identities = 81/218 (37%), Positives = 108/218 (49%), Gaps = 24/218 (11%)

Query: 22  PLPLLLLLALGTRGGCAAPAP--------APRAEDLSLGVEWLSRFGYLPPADPTTGQLQ 73
           PL  L LL        AAP+P        AP+  D  L V++L+ F   P        L+
Sbjct: 13  PLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKT-DKELAVQYLNTFYGCPKESCNLFVLK 71

Query: 74  TQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKW 133
                   +  MQ+F GL  TG LD+ T+  M+ PRC  PD+            P   KW
Sbjct: 72  D------TLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA------NYNFFPRKPKW 119

Query: 134 NKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKAD 193
           +K  +++R+  +  D  L  +TV      A +VWSD+ PL F  +    ADI I+F + +
Sbjct: 120 DKNQITYRIIGYTPD--LDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWE 177

Query: 194 HNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWT 231
           H DGYPFDG  G +AHAF PG     GD+HFDDDE WT
Sbjct: 178 HGDGYPFDGKDGLLAHAFAPG-TGVGGDSHFDDDELWT 214


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  170 bits (431), Expect = 3e-42
 Identities = 150/531 (28%), Positives = 233/531 (43%), Gaps = 104/531 (19%)

Query: 40  PAPAPRAE---DLSLGVEWLSRFGYLP------PADPTTGQLQTQEELSKAITAMQQFGG 90
           P+P  +A+   DL     +LSR+G+        P+     +      L++A+   Q+   
Sbjct: 38  PSPLRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANA 97

Query: 91  LEATGILDEATLALMKTPRCSLPDL--------------PVLTQARRRRQAP-------- 128
           L A+G LD ATLA M  PRC +PD+              P   ++RR  +AP        
Sbjct: 98  LPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGW 157

Query: 129 ---------APTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHE-- 177
                    A   ++KR LSWR+      S L     R ++  A ++WS++ PL+F E  
Sbjct: 158 QPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDL 217

Query: 178 -VAGSAADIQIDFSKADHNDGYP--FDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRS 234
              G+A DI++ F +  H  G P  FDG G   AHA+        GD HFDDDE +T  +
Sbjct: 218 AAPGAAVDIKLGFGRGRHL-GCPRAFDGSGQEFAHAW------RLGDIHFDDDEHFTPPT 270

Query: 235 SDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLY 294
           SD  G+ L  VAVHE GH +GL H     SIM+P Y   +     + L + D+  + +LY
Sbjct: 271 SDT-GISLLKVAVHEIGHVLGLPHTYRTGSIMQPNY---IPQEPAFELDWSDRKAIQKLY 326

Query: 295 GVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYF 354
           G  E    TA                      D   +    +  V  +R   +FF+  ++
Sbjct: 327 GSCEGSFDTA---------------------FDWIRKERNQYGEV-MVRFSTYFFRNSWY 364

Query: 355 WRL-TRDRHLVSLQPAQMHRFWRGLPLH-LDSVDAVYERTSDHKIVFFKGDRYWVF---K 409
           W    R+       P Q+   W G+P H +D+   ++    D +  FF+G++YW +   K
Sbjct: 365 WLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDER-YFFQGNQYWRYDSDK 423

Query: 410 DNNVEE-----GYPRPVSD-FSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDP 463
           D  + E      YP+ +S+ F   P  +D AF        YFFK+ L + +D +   +  
Sbjct: 424 DQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLN 483

Query: 464 GYP-----------AQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLD 503
            YP            Q+  +R + S       ++  + +FF+G  YWKV++
Sbjct: 484 SYPKRITEVFPAVIPQNHPFRNIDSAY---YSYAYNSIFFFKGNAYWKVVN 531


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  158 bits (400), Expect = 1e-38
 Identities = 90/258 (34%), Positives = 134/258 (51%), Gaps = 13/258 (5%)

Query: 42  PAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEAT 101
           P P+       ++W     YL        + +    L   +  MQ+F GL  TG+L+   
Sbjct: 19  PLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRV 78

Query: 102 LALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMY 161
           + +M+ PRC +PD+   +        P   KW  + +++R+ ++ RD P  H TV  L+ 
Sbjct: 79  IEIMQKPRCGVPDVAEYSLF------PNSPKWTSKVVTYRIVSYTRDLP--HITVDRLVS 130

Query: 162 YALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGD 221
            AL +W    PL+F +V    ADI I F++  H D YPFDGPG T+AHAF PG     GD
Sbjct: 131 KALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPG-TGLGGD 189

Query: 222 THFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYG 281
            HFD+DE WT  SS   G++    A HE GH++G+ H +  +++M P Y    GDP  + 
Sbjct: 190 AHFDEDERWTDGSS--LGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGN--GDPQNFK 245

Query: 282 LPYEDKVRVWQLYGVRES 299
           L  +D   + +LYG R +
Sbjct: 246 LSQDDIKGIQKLYGKRSN 263


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  138 bits (348), Expect = 1e-32
 Identities = 82/224 (36%), Positives = 116/224 (51%), Gaps = 18/224 (8%)

Query: 72  LQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPT 131
           L TQE  ++ +    + G    T +LD    AL+  P C +PD            +P   
Sbjct: 48  LLTQETQTQLLQQFHRNG----TDLLDMQMHALLHQPHCGVPD------GSDTSISPGRC 97

Query: 132 KWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSK 191
           KWNK  L++R+  +P D  +    V+  +Y A+ +WS++ PL F +V    ADI++ F +
Sbjct: 98  KWNKHTLTYRIINYPHD--MKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQ 155

Query: 192 ADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFG 251
             H DG+PFDGPGG + HAF P +    G  HFD +E W   S+   G +LF VA HE G
Sbjct: 156 WAHEDGWPFDGPGGILGHAFLP-NSGNPGVVHFDKNEHW---SASDTGYNLFLVATHEIG 211

Query: 252 HAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYG 295
           H++GL H     SIM P Y     DP  + L  +D  R+  LYG
Sbjct: 212 HSLGLQHSGNQSSIMYPTYW--YHDPRTFQLSADDIQRIQHLYG 253


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  120 bits (301), Expect = 4e-27
 Identities = 80/224 (35%), Positives = 105/224 (46%), Gaps = 32/224 (14%)

Query: 22  PLPLLLLLALGTRGGCAAPAPAPRAE--------------DLSLGVEWLSRFGYLPPADP 67
           PL L+LL+      GC   AP  R                D  L  E+L R+GY   A+ 
Sbjct: 6   PLVLVLLVL-----GCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAE- 59

Query: 68  TTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQA 127
                   + L  A+  +Q+   L  TG LD ATL  M+TPRC +PDL       R +  
Sbjct: 60  ---MRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLG------RFQTF 110

Query: 128 PAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQI 187
               KW+  N+++ ++ +  D P     +      A  +WS + PL F  V    ADI I
Sbjct: 111 EGDLKWHHHNITYWIQNYSEDLPRA--VIDDAFARAFALWSAVTPLTFTRVYSRDADIVI 168

Query: 188 DFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWT 231
            F  A+H DGYPFDG  G +AHAF PG     GD HFDDDE W+
Sbjct: 169 QFGVAEHGDGYPFDGKDGLLAHAFPPG-PGIQGDAHFDDDELWS 211



 Score =  106 bits (265), Expect = 5e-23
 Identities = 91/324 (28%), Positives = 134/324 (41%), Gaps = 56/324 (17%)

Query: 219 AGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPL 278
           A  ++FD D+ W F      G  LF VA HEFGHA+GL H +   ++M P Y+   G PL
Sbjct: 374 ATTSNFDSDKKWGFCPDQ--GYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPL 431

Query: 279 RYGLPYEDKVRVWQLYGVRESVSP------TAQPEEPPLL------------------PE 314
                 +D   +  LYG R    P      T QP  PP +                    
Sbjct: 432 H----KDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTG 487

Query: 315 PPDNRSSAPPR-----------KDVPHRCSTH-FDAVAQIRGEAFFFKGKYFWRLTRDRH 362
           PP    + PP              V   C+ + FDA+A+I  + + FK   +WR +  R 
Sbjct: 488 PPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRG 547

Query: 363 LVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVS 422
                P  +   W  LP  LDS   V+E     K+ FF G + WV+   +V    PR + 
Sbjct: 548 SRPQGPFLIADKWPALPRKLDS---VFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLD 602

Query: 423 DFSLPPGGIDAA----FSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPS 477
              L   G D A       +   +   F  +  WR+D   + +DP   ++   ++ GVP 
Sbjct: 603 KLGL---GADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPL 659

Query: 478 TLDDAMRWSDGASYFFRGQEYWKV 501
              D  ++ + A YF + + YW+V
Sbjct: 660 DTHDVFQYREKA-YFCQDRFYWRV 682


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score =  110 bits (274), Expect = 5e-24
 Identities = 71/182 (39%), Positives = 97/182 (53%), Gaps = 19/182 (10%)

Query: 98  DEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVR 157
           D A L L   P   +P  P+  + RR    PA  +W+  NL++R+ +FPR+     +T R
Sbjct: 54  DVAALGLSAVPPTRVPG-PLAPRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRR 112

Query: 158 ALMYYALKVWSDIAPLNFHEVA-GSAADIQIDFSKADHND------GYPFDGPGGTVAHA 210
           AL   A ++WSD++P +F EVA    +D++I F   +H D       + FDGP G +AHA
Sbjct: 113 ALA-AAFRMWSDVSPFSFREVAPEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHA 171

Query: 211 FFPGHHHTAGDTHFDDDEAWTF---RSSDAHGM---DLFAVAVHEFGHAIGLSHVAAAHS 264
           FFP H    G  HFDD E W     R S   G+   DL  VA HE GHA+GL H     +
Sbjct: 172 FFPPH----GGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRA 227

Query: 265 IM 266
           +M
Sbjct: 228 LM 229


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 54/154 (35%), Positives = 84/154 (54%), Gaps = 10/154 (6%)

Query: 53  VEWLSRFGYLPPADPTTGQLQTQ-EELSKAITAMQQFGGLEATGILDEATLALMKTPRCS 111
           V++LS++GYL    P  G    + E++++A+ A Q+   L  +G LD+AT A M+ PRC 
Sbjct: 29  VDYLSQYGYLQK--PLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCG 86

Query: 112 LPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIA 171
           L D       ++  +     +W K++L++R+   P  S L   T RA +  A + WS++A
Sbjct: 87  LED----PFNQKTLKYLLLGRWRKKHLTFRILNLP--STLPPHTARAALRQAFQDWSNVA 140

Query: 172 PLNFHEVAGSAADIQIDF-SKADHNDGYPFDGPG 204
           PL F EV   AADI++ F  +        FDGPG
Sbjct: 141 PLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPG 174


>gi|11321561 hemopexin precursor [Homo sapiens]
          Length = 462

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 61/209 (29%), Positives = 89/209 (42%), Gaps = 28/209 (13%)

Query: 324 PRKDVPHRCST--HFDAVA-QIRGEAFFFKGKYFWRLTR-DRHLVSLQPAQMHRFWRGLP 379
           P  DV  RCS    FDA      G   FFKG++ W+  + DR L+S +       W+  P
Sbjct: 42  PDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRELISER-------WKNFP 94

Query: 380 LHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSD-FSLPPGGIDAAFSW- 437
                VDA + R   + +   KGD+ WV+     E+GYP+ + D F   P  +DAA    
Sbjct: 95  ---SPVDAAF-RQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECH 150

Query: 438 ---AHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFR 494
                 +   FF+    W +D  T  M      +   W  V      A+RW  G  Y F+
Sbjct: 151 RGECQAEGVLFFQGDREWFWDLATGTM------KERSWPAV-GNCSSALRWL-GRYYCFQ 202

Query: 495 GQEYWKVLDGELEVAPGYPQSTARDWLVC 523
           G ++ +      EV P YP+     ++ C
Sbjct: 203 GNQFLRFDPVRGEVPPRYPRDVRDYFMPC 231



 Score = 33.1 bits (74), Expect = 0.75
 Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 18/136 (13%)

Query: 331 RCSTHFDAVAQI---RGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDA 387
           RCS H    A      G  + F G ++WRL   R      P   H++    P    +VDA
Sbjct: 256 RCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPI-AHQW----PQGPSAVDA 310

Query: 388 VYERTSDHKIVFFKGDRYWVFKDN---NVEEGYPRPVSDFSLPPGGI-----DAAFSWAH 439
            +  + + K+   +G + +VF       +  GYP+ +      P GI     DAAF    
Sbjct: 311 AF--SWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPG 368

Query: 440 NDRTYFFKDQLYWRYD 455
           + R +    +  W  D
Sbjct: 369 SSRLHIMAGRRLWWLD 384


>gi|88853069 vitronectin precursor [Homo sapiens]
          Length = 478

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 78/284 (27%), Positives = 116/284 (40%), Gaps = 43/284 (15%)

Query: 301 SPTAQPEEPPLLPE----PPDNRSSAP----PRKDVP----HRCSTH-FDAVAQIR-GEA 346
           +P  +PEE    PE     P+   S P    P +  P      CS   FDA   ++ G  
Sbjct: 113 TPVLKPEEEAPAPEVGASKPEGIDSRPETLHPGRPQPPAEEELCSGKPFDAFTDLKNGSL 172

Query: 347 FFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTS-DHKIVFFKGDRY 405
           F F+G+Y + L  ++ +    P  +   W G+      +DA + R +   K   FKG +Y
Sbjct: 173 FAFRGQYCYELD-EKAVRPGYPKLIRDVW-GIE---GPIDAAFTRINCQGKTYLFKGSQY 227

Query: 406 WVFKDNNVEEGYPRPVSD-FSLPPGGIDAAF-----SWAHNDRTYFFKDQLYWRYDDHTR 459
           W F+D  ++  YPR +SD F   P  +DAA      S++  +R YFFK + YW Y    +
Sbjct: 228 WRFEDGVLDPDYPRNISDGFDGIPDNVDAALALPAHSYSGRERVYFFKGKQYWEYQFQHQ 287

Query: 460 HMDPGYPAQSPLWRGVPSTLDD--AMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTA 517
                 P+Q        S + +  AM   D     F    +W    G        PQ  +
Sbjct: 288 ------PSQEECEGSSLSAVFEHFAMMQRDSWEDIFE-LLFW----GRTSAGTRQPQFIS 336

Query: 518 RDWLVCGDSQADGSVAAGV---DAAEGPRAPPGQHDQSRSEDGY 558
           RDW      Q D ++A  +     A  P     Q  + R+  GY
Sbjct: 337 RDWHGV-PGQVDAAMAGRIYISGMAPRPSLAKKQRFRHRNRKGY 379


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 33/93 (35%), Positives = 49/93 (52%), Gaps = 11/93 (11%)

Query: 377 GLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPV-SDFSLPPG--GIDA 433
           G  +H D+ +    RT D     F+  ++WV +++ +  GYPR V S F  P     IDA
Sbjct: 261 GGDVHFDNDET---RTKD-----FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDA 312

Query: 434 AFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYP 466
           A       +T+FF    YWRYD++ + +D GYP
Sbjct: 313 AIYEKDTGKTHFFVANEYWRYDENMQSVDAGYP 345



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 34/76 (44%), Positives = 42/76 (55%), Gaps = 4/76 (5%)

Query: 163 ALKVWSDIAPLNFHEVAGSAADIQIDFS-KADHNDGYPFDGPGGTVAHAFFPGHHHTAGD 221
           A ++WS+ + L F     S  DI + F   AD +D  PF G  G +AHAF PG     GD
Sbjct: 205 AFELWSNASALTFTRDFESEGDIILSFVFLADLHDNSPFYGHDGCLAHAFPPG-PGIGGD 263

Query: 222 THFDDDEAWT--FRSS 235
            HFD+DE  T  FRSS
Sbjct: 264 VHFDNDETRTKDFRSS 279


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.448 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,173,804
Number of Sequences: 37866
Number of extensions: 1775086
Number of successful extensions: 10976
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 9604
Number of HSP's gapped (non-prelim): 1151
length of query: 603
length of database: 18,247,518
effective HSP length: 108
effective length of query: 495
effective length of database: 14,157,990
effective search space: 7008205050
effective search space used: 7008205050
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.