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Search of human proteins with 162329608
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
(886 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 1777 0.0
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 1558 0.0
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 1556 0.0
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 1253 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 965 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 938 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 938 0.0
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 938 0.0
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 928 0.0
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 900 0.0
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 850 0.0
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 833 0.0
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 800 0.0
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 237 3e-62
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 237 3e-62
gi|4826894 phosphodiesterase 1C [Homo sapiens] 234 2e-61
gi|4505677 phosphodiesterase 1B [Homo sapiens] 231 2e-60
gi|9506959 phosphodiesterase 7B [Homo sapiens] 216 1e-55
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 214 3e-55
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 214 3e-55
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 211 2e-54
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 211 2e-54
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 211 2e-54
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 211 2e-54
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 211 2e-54
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 209 7e-54
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 194 3e-49
gi|40254434 phosphodiesterase 3B [Homo sapiens] 178 2e-44
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 177 5e-44
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 177 5e-44
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 1777 bits (4602), Expect = 0.0
Identities = 886/886 (100%), Positives = 886/886 (100%)
Query: 1 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ 60
MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ
Sbjct: 1 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ 60
Query: 61 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR 120
PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR
Sbjct: 61 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR 120
Query: 121 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP 180
SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP
Sbjct: 121 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP 180
Query: 181 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW 240
FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
Sbjct: 181 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW 240
Query: 241 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI 300
CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI
Sbjct: 241 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI 300
Query: 301 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD 360
PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
Sbjct: 301 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD 360
Query: 361 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML 420
QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML
Sbjct: 361 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML 420
Query: 421 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV 480
TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
Sbjct: 421 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV 480
Query: 481 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM 540
SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM
Sbjct: 481 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM 540
Query: 541 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE 600
VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE
Sbjct: 541 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE 600
Query: 601 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 660
LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL
Sbjct: 601 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 660
Query: 661 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE 720
VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
Sbjct: 661 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE 720
Query: 721 ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT 780
ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT
Sbjct: 721 ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT 780
Query: 781 QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP 840
QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP
Sbjct: 781 QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP 840
Query: 841 STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 886
STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 841 STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 886
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 1558 bits (4033), Expect = 0.0
Identities = 781/784 (99%), Positives = 781/784 (99%)
Query: 103 GSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMS 162
G S FEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMS
Sbjct: 42 GRSVSFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMS 101
Query: 163 RNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATL 222
RNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATL
Sbjct: 102 RNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATL 161
Query: 223 SEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQ 282
SEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQ
Sbjct: 162 SEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQ 221
Query: 283 VSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLM 342
VSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLM
Sbjct: 222 VSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLM 281
Query: 343 HSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQER 402
HSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQER
Sbjct: 282 HSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQER 341
Query: 403 DLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLE 462
DLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLE
Sbjct: 342 DLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLE 401
Query: 463 ILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIF 522
ILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIF
Sbjct: 402 ILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIF 461
Query: 523 QNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV 582
QNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV
Sbjct: 462 QNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV 521
Query: 583 LRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQ 642
LRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQ
Sbjct: 522 LRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQ 581
Query: 643 VGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPP 702
VGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPP
Sbjct: 582 VGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPP 641
Query: 703 LPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLE 762
LPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLE
Sbjct: 642 LPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLE 701
Query: 763 VMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLP 822
VMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLP
Sbjct: 702 VMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLP 761
Query: 823 AWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSG 882
AWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSG
Sbjct: 762 AWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSG 821
Query: 883 GDPT 886
GDPT
Sbjct: 822 GDPT 825
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 1556 bits (4029), Expect = 0.0
Identities = 782/787 (99%), Positives = 782/787 (99%), Gaps = 4/787 (0%)
Query: 100 AGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPK 159
AG G FEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPK
Sbjct: 78 AGAG----FEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPK 133
Query: 160 TMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCK 219
TMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCK
Sbjct: 134 TMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCK 193
Query: 220 ATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRS 279
ATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRS
Sbjct: 194 ATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRS 253
Query: 280 GNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLK 339
GNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLK
Sbjct: 254 GNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLK 313
Query: 340 KLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIF 399
KLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIF
Sbjct: 314 KLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIF 373
Query: 400 QERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFT 459
QERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFT
Sbjct: 374 QERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFT 433
Query: 460 DLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNC 519
DLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNC
Sbjct: 434 DLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNC 493
Query: 520 DIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDR 579
DIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDR
Sbjct: 494 DIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDR 553
Query: 580 IQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVE 639
IQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVE
Sbjct: 554 IQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVE 613
Query: 640 KSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPG 699
KSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPG
Sbjct: 614 KSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPG 673
Query: 700 HPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQE 759
HPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQE
Sbjct: 674 HPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQE 733
Query: 760 SLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSP 819
SLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSP
Sbjct: 734 SLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSP 793
Query: 820 LLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGG 879
LLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGG
Sbjct: 794 LLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGG 853
Query: 880 GSGGDPT 886
GSGGDPT
Sbjct: 854 GSGGDPT 860
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 1253 bits (3242), Expect = 0.0
Identities = 625/626 (99%), Positives = 626/626 (100%)
Query: 261 KFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 320
+FKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ
Sbjct: 22 QFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 81
Query: 321 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 380
PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF
Sbjct: 82 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 141
Query: 381 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 440
CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD
Sbjct: 142 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 201
Query: 441 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 500
VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES
Sbjct: 202 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 261
Query: 501 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 560
VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV
Sbjct: 262 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 321
Query: 561 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 620
ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE
Sbjct: 322 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 381
Query: 621 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 680
RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY
Sbjct: 382 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 441
Query: 681 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 740
SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS
Sbjct: 442 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 501
Query: 741 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 800
GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE
Sbjct: 502 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 561
Query: 801 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 860
EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS
Sbjct: 562 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 621
Query: 861 ACAGTFGEDTSALPAPGGGGSGGDPT 886
ACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 622 ACAGTFGEDTSALPAPGGGGSGGDPT 647
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 965 bits (2494), Expect = 0.0
Identities = 518/786 (65%), Positives = 606/786 (77%), Gaps = 76/786 (9%)
Query: 1 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPI--------------RIQQR 46
+ PP PS + P P Q L+PPP P P R++ R
Sbjct: 57 LPPPPPPSPQ------PQP---QCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHR 107
Query: 47 GYSDSAERAERERQPH-RPIERAD-AMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGS 104
GYSD+ ER + R ++R A++T RPGL+ +RMSWPSSF G
Sbjct: 108 GYSDT------ERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGL----------- 150
Query: 105 SRRFEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRESFLYRSDSDYDMSPKTMS 162
RRF+ +NG S GRSPLD SPG L+L A SQRRESFLYRSDSDYD+SPK+MS
Sbjct: 151 -RRFDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMS 207
Query: 163 RNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP--VPSNKRSPLGGPTPVCKA 220
RNSS+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+ PS KRSP+ + KA
Sbjct: 208 RNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPS-KRSPMCNQPSINKA 266
Query: 221 TLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSG 280
T++EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KFKRMLNRELTHLSEMSRSG
Sbjct: 267 TITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSG 326
Query: 281 NQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKK 340
NQVSE+IS TFLDKQ+EVEIPSPT KE+EK++ +PMSQI+G+KK
Sbjct: 327 NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKK 369
Query: 341 LMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQ 400
LMHS+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +++ +G R LT IM+ IFQ
Sbjct: 370 LMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQ 429
Query: 401 ERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTD 460
ERDLLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+QSTHVLL+TPAL+AVFTD
Sbjct: 430 ERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTD 489
Query: 461 LEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCD 520
LEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQE+NCD
Sbjct: 490 LEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCD 549
Query: 521 IFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRI 580
IFQNL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVETKKVTSSGVLLLDNYSDRI
Sbjct: 550 IFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRI 609
Query: 581 QVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEK 640
QVL+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERERGMEISPMCDKH ASVEK
Sbjct: 610 QVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEK 669
Query: 641 SQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGH 700
SQVGFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S I QSPSP P++ G
Sbjct: 670 SQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEE--GR 727
Query: 701 PPLPDKFQFELTLEEEEE---EEISMAQI----PCTAQEALTAQGLSGVEEALDATIAWE 753
+KFQFELTLEE+ E E+ S +Q+ C+ + L Q E LD + E
Sbjct: 728 QGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEE 787
Query: 754 ASPAQE 759
A +E
Sbjct: 788 AVGEEE 793
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 938 bits (2425), Expect = 0.0
Identities = 483/619 (78%), Positives = 534/619 (86%), Gaps = 22/619 (3%)
Query: 104 SSRRFEAENGPTPSPGRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKT 160
S F+ ENGP SPGRSPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK
Sbjct: 91 SQECFDVENGP--SPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA 148
Query: 161 MSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKA 220
MSRNSS+ SE H +DLIVTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV +
Sbjct: 149 MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV 208
Query: 221 TLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSG 280
EE+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSG
Sbjct: 209 NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG 268
Query: 281 NQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKK 340
NQVSEYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI+G+KK
Sbjct: 269 NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKK 313
Query: 341 LMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQ 400
LMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQ
Sbjct: 314 LMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ 373
Query: 401 ERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTD 460
ERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTD
Sbjct: 374 ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTD 433
Query: 461 LEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCD 520
LEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CD
Sbjct: 434 LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCD 493
Query: 521 IFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRI 580
IF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRI
Sbjct: 494 IFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRI 553
Query: 581 QVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEK 640
QVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEK
Sbjct: 554 QVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEK 613
Query: 641 SQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGH 700
SQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R
Sbjct: 614 SQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DC 671
Query: 701 PPLPDKFQFELTLEEEEEE 719
L +KFQFELTL+EE+ E
Sbjct: 672 QGLMEKFQFELTLDEEDSE 690
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 938 bits (2425), Expect = 0.0
Identities = 483/619 (78%), Positives = 534/619 (86%), Gaps = 22/619 (3%)
Query: 104 SSRRFEAENGPTPSPGRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKT 160
S F+ ENGP SPGRSPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK
Sbjct: 91 SQECFDVENGP--SPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA 148
Query: 161 MSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKA 220
MSRNSS+ SE H +DLIVTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV +
Sbjct: 149 MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV 208
Query: 221 TLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSG 280
EE+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSG
Sbjct: 209 NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG 268
Query: 281 NQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKK 340
NQVSEYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI+G+KK
Sbjct: 269 NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKK 313
Query: 341 LMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQ 400
LMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQ
Sbjct: 314 LMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ 373
Query: 401 ERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTD 460
ERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTD
Sbjct: 374 ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTD 433
Query: 461 LEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCD 520
LEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CD
Sbjct: 434 LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCD 493
Query: 521 IFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRI 580
IF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRI
Sbjct: 494 IFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRI 553
Query: 581 QVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEK 640
QVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEK
Sbjct: 554 QVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEK 613
Query: 641 SQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGH 700
SQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R
Sbjct: 614 SQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DC 671
Query: 701 PPLPDKFQFELTLEEEEEE 719
L +KFQFELTL+EE+ E
Sbjct: 672 QGLMEKFQFELTLDEEDSE 690
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 938 bits (2424), Expect = 0.0
Identities = 482/615 (78%), Positives = 533/615 (86%), Gaps = 22/615 (3%)
Query: 108 FEAENGPTPSPGRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRN 164
F+ ENGP SPGRSPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK MSRN
Sbjct: 80 FDVENGP--SPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRN 137
Query: 165 SSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSE 224
SS+ SE H +DLIVTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV + E
Sbjct: 138 SSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQE 197
Query: 225 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 284
E+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 198 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 257
Query: 285 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 344
EYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI+G+KKLMHS
Sbjct: 258 EYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHS 302
Query: 345 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 404
+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQERDL
Sbjct: 303 SSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDL 362
Query: 405 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 464
LK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEIL
Sbjct: 363 LKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEIL 422
Query: 465 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 524
AA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF N
Sbjct: 423 AAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMN 482
Query: 525 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 584
L+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLR
Sbjct: 483 LTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR 542
Query: 585 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 644
NMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVG
Sbjct: 543 NMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVG 602
Query: 645 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 704
FIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R L
Sbjct: 603 FIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLM 660
Query: 705 DKFQFELTLEEEEEE 719
+KFQFELTL+EE+ E
Sbjct: 661 EKFQFELTLDEEDSE 675
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 928 bits (2398), Expect = 0.0
Identities = 478/663 (72%), Positives = 553/663 (83%), Gaps = 33/663 (4%)
Query: 108 FEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 165
F+ +NG S GRSPLD SPG L+L A SQRRESFLYRSDSDYD+SPK+MSRNS
Sbjct: 17 FDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNS 74
Query: 166 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP--VPSNKRSPLGGPTPVCKATLS 223
S+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+ PS KRSP+ + KAT++
Sbjct: 75 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPS-KRSPMCNQPSINKATIT 133
Query: 224 EETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQV 283
EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KFKRMLNRELTHLSEMSRSGNQV
Sbjct: 134 EEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQV 193
Query: 284 SEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMH 343
SE+IS TFLDKQ+EVEIPSPT KE+EK++ +PMSQI+G+KKLMH
Sbjct: 194 SEFISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMH 236
Query: 344 SNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERD 403
S+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +++ +G R LT IM+ IFQERD
Sbjct: 237 SSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD 296
Query: 404 LLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEI 463
LLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+QSTHVLL+TPAL+AVFTDLEI
Sbjct: 297 LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEI 356
Query: 464 LAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQ 523
LAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQE+NCDIFQ
Sbjct: 357 LAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQ 416
Query: 524 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 583
NL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVL
Sbjct: 417 NLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 476
Query: 584 RNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQV 643
+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERERGMEISPMCDKH ASVEKSQV
Sbjct: 477 QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQV 536
Query: 644 GFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPL 703
GFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S I QSPSP P++ G
Sbjct: 537 GFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEE--GRQGQ 594
Query: 704 PDKFQFELTLEEEEE---EEISMAQI----PCTAQEALTAQGLSGVEEALDATIAWEASP 756
+KFQFELTLEE+ E E+ S +Q+ C+ + L Q E LD + EA
Sbjct: 595 TEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVG 654
Query: 757 AQE 759
+E
Sbjct: 655 EEE 657
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 900 bits (2327), Expect = 0.0
Identities = 484/720 (67%), Positives = 555/720 (77%), Gaps = 61/720 (8%)
Query: 22 GQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAE-RERQPHRPIERADAMDTSDRPGLR 80
G+ ++ P+HLWRQPR PIRIQQR YSD + A RER D S RP LR
Sbjct: 21 GRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRER------------DLSPRPELR 68
Query: 81 TTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGL--VLHAGAA 138
+R+SWP S S RRF+ ENG S GR LD Q+SPGL ++ A
Sbjct: 69 KSRLSWPVS--------------SCRRFDLENGL--SCGRRALDPQSSPGLGRIMQAPVP 112
Query: 139 TSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLL 198
SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED+IVTPFAQVLASLR+VRSN + L
Sbjct: 113 HSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAAL 172
Query: 199 TNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEM 257
+ + K+ P+G P+ + +E+T Q+LA ETL+ELDWCL+QLET+QT SV EM
Sbjct: 173 ARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEM 232
Query: 258 ASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPR 317
AS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E AP
Sbjct: 233 ASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE-----AP--- 284
Query: 318 PSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGL 377
QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL
Sbjct: 285 ------------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGL 332
Query: 378 NIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLH 437
++F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VAYHNSLH
Sbjct: 333 DVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLH 392
Query: 438 AADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN 497
AADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSELALMYN
Sbjct: 393 AADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYN 452
Query: 498 DESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLK 557
D SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM LLADLK
Sbjct: 453 DASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLK 512
Query: 558 TMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQG 617
TMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQG
Sbjct: 513 TMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQG 572
Query: 618 DRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRD 677
DRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDTLEDNR+
Sbjct: 573 DRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNRE 632
Query: 678 WYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPCTAQEAL 734
WY S I +SPS E G PD+FQFELTL EEE+EEE + A+EAL
Sbjct: 633 WYQSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 686
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 850 bits (2197), Expect = 0.0
Identities = 447/633 (70%), Positives = 511/633 (80%), Gaps = 34/633 (5%)
Query: 108 FEAENGPTPSPGRSPLDSQASPGL--VLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 165
F+ ENG S GR LD Q+SPGL ++ A SQRRESFLYRSDSDY++SPK MSRNS
Sbjct: 50 FDLENGL--SCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNS 107
Query: 166 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSE 224
SV S+ H ED+IVTPFAQVLASLR+VRSN + L + + K+ P+G P+ + +E
Sbjct: 108 SVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAE 167
Query: 225 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 284
+T Q+LA ETL+ELDWCL+QLET+QT SV EMAS+KFKR+LNRELTHLSE SRSGNQVS
Sbjct: 168 DTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVS 227
Query: 285 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 344
EYIS TFLD+Q EVE+P T +E AP QPMS+I+GL L HS
Sbjct: 228 EYISRTFLDQQTEVELPKVTAEE-----AP---------------QPMSRISGLHGLCHS 267
Query: 345 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 404
SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL++F V++ +G R LT I++ IFQERDL
Sbjct: 268 ASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDL 327
Query: 405 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 464
LK F+IP DT+ TY+L LE HYHA+VAYHNSLHAADV QSTHVLLATPAL+AVFTDLEIL
Sbjct: 328 LKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEIL 387
Query: 465 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 524
AALFA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ +NCDIFQN
Sbjct: 388 AALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQN 447
Query: 525 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 584
LS +QR SLR+MVIDMVLATDMSKHM LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+
Sbjct: 448 LSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQ 507
Query: 585 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 644
N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQGDRERE G++ISPMCDKHTASVEKSQVG
Sbjct: 508 NLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVG 567
Query: 645 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 704
FIDYI HPLWETWADLVHPDAQ++LDTLEDNR+WY S I +SPS E G P
Sbjct: 568 FIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG------P 621
Query: 705 DKFQFELTL---EEEEEEEISMAQIPCTAQEAL 734
D+FQFELTL EEE+EEE + A+EAL
Sbjct: 622 DRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 654
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 833 bits (2153), Expect = 0.0
Identities = 433/606 (71%), Positives = 494/606 (81%), Gaps = 30/606 (4%)
Query: 133 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR 192
+ A SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED+IVTPFAQVLASLR+VR
Sbjct: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
Query: 193 SNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTY 251
SN + L + + K+ P+G P+ + +E+T Q+LA ETL+ELDWCL+QLET+QT
Sbjct: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
Query: 252 RSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQ 311
SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E
Sbjct: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE---- 176
Query: 312 QAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELEN 371
AP QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+
Sbjct: 177 -AP---------------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELED 220
Query: 372 LNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVA 431
NKWGL++F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VA
Sbjct: 221 TNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVA 280
Query: 432 YHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSE 491
YHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSE
Sbjct: 281 YHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSE 340
Query: 492 LALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMT 551
LALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM
Sbjct: 341 LALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMN 400
Query: 552 LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMA 611
LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMA
Sbjct: 401 LLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMA 460
Query: 612 EFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDT 671
EFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDT
Sbjct: 461 EFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDT 520
Query: 672 LEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPC 728
LEDNR+WY S I +SPS E G PD+FQFELTL EEE+EEE +
Sbjct: 521 LEDNREWYQSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETA 574
Query: 729 TAQEAL 734
A+EAL
Sbjct: 575 LAKEAL 580
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 800 bits (2065), Expect = 0.0
Identities = 404/504 (80%), Positives = 447/504 (88%), Gaps = 19/504 (3%)
Query: 216 PVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSE 275
PVC +EE+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSE
Sbjct: 34 PVC--LFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSE 91
Query: 276 MSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQI 335
MSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI
Sbjct: 92 MSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQI 136
Query: 336 TGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIM 395
+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIM
Sbjct: 137 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 196
Query: 396 YMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALD 455
Y IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALD
Sbjct: 197 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALD 256
Query: 456 AVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 515
AVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ
Sbjct: 257 AVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 316
Query: 516 EDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDN 575
E++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDN
Sbjct: 317 EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDN 376
Query: 576 YSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHT 635
Y+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHT
Sbjct: 377 YTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHT 436
Query: 636 ASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEES 695
ASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++
Sbjct: 437 ASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQN 496
Query: 696 RGPGHPPLPDKFQFELTLEEEEEE 719
R L +KFQFELTL+EE+ E
Sbjct: 497 R--DCQGLMEKFQFELTLDEEDSE 518
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 237 bits (605), Expect = 3e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 369 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 428
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 429 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 487
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 488 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 547
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 548 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 607
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 608 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 659
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 237 bits (605), Expect = 3e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 369 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 428
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 429 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 487
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 488 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 547
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 548 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 607
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 608 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 659
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 234 bits (598), Expect = 2e-61
Identities = 119/306 (38%), Positives = 187/306 (61%), Gaps = 13/306 (4%)
Query: 367 QELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHY 426
+ L++++KW ++F +++ +G +L I Y + DL+ +F+IP+ +V+++ LE Y
Sbjct: 161 EALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGY 220
Query: 427 HADV-AYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFL 485
YHN +HAADV Q+ H LL + T+LEI A +F+AAIHD +H G +N F
Sbjct: 221 SKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFH 280
Query: 486 INTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVIDMVLAT 544
I T S+ A++YND SVLENHHL+ ++LLQ+D +I NLSK + R +VI+MV+AT
Sbjct: 281 IQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMAT 340
Query: 545 DMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQ 604
DMS H + +KT ++ + ++ + L M+H AD+S+P K +L+ +
Sbjct: 341 DMSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHR 389
Query: 605 WTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD 664
WT ++ EFF+QGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 390 WTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKI 449
Query: 665 AQEILD 670
++D
Sbjct: 450 VSPLID 455
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 231 bits (590), Expect = 2e-60
Identities = 119/309 (38%), Positives = 189/309 (61%), Gaps = 14/309 (4%)
Query: 369 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 428
L+NL+ W ++F ++ A +L I++ + +L+ +F+IP +++++ LE Y
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 429 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 487
YHN +HAADV Q+ H L + +++E+LA +FAAAIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 488 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 547
T SE A++YND SVLENHH++ F+L+Q+D +IF NL+K + LR +VI+MVLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 548 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 607
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 608 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQE 667
+M EFF+QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 668 ILDTLEDNR 676
+ D ED++
Sbjct: 447 LAD--EDSK 453
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 216 bits (549), Expect = 1e-55
Identities = 126/393 (32%), Positives = 208/393 (52%), Gaps = 20/393 (5%)
Query: 332 MSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNK---WGLNIFCVSDYAGG 388
+ ++ ++ H++ L IP+ + E+ L Q L+K W +IF G
Sbjct: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
Query: 389 RSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVL 448
SL ++ +F L+ F++ + T+ +++ +++ YH+ YHN++HAADV Q+ H
Sbjct: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
Query: 449 LATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA 508
L P L + T L+I+ L AAA HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
Query: 509 VGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSS 568
+L+E + +L K Q + + + ++LATD+++ L LK + K
Sbjct: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
Query: 569 GVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEIS 628
L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EF++QG+ E++ +EIS
Sbjct: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
Query: 629 PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD--AQEILDTLEDNRDWYYSAIRQS 686
P+C++ S+ Q+GF+ YIV PL+ WA ++ +L L N+ + S +
Sbjct: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL--- 417
Query: 687 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 719
P + SRG PD E EE+E
Sbjct: 418 ---PRQHRSRGSSGSG-PDHDHAGQGTESEEQE 446
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 214 bits (545), Expect = 3e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 365 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 424
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 442 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 501
Query: 425 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 484
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 502 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 561
Query: 485 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 543
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 562 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 621
Query: 544 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 592
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 622 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 681
Query: 593 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 651
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 682 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 741
Query: 652 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 692
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 742 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 783
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 214 bits (545), Expect = 3e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 365 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 424
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
Query: 425 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 484
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
Query: 485 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 543
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
Query: 544 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 592
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
Query: 593 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 651
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
Query: 652 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 692
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 360 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 419
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 495 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 554
Query: 420 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 479
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 555 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 614
Query: 480 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 538
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 615 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 674
Query: 539 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 589
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 675 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 732
Query: 590 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 648
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 733 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 792
Query: 649 IVHPLWETWADLVHPDAQEILDTLEDN 675
+ +++ W H A ++ L DN
Sbjct: 793 FITDMFDAWDAFAHLPA--LMQHLADN 817
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 360 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 419
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 522 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 581
Query: 420 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 479
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 582 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 641
Query: 480 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 538
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 642 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 701
Query: 539 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 589
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 702 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 759
Query: 590 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 648
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 760 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 819
Query: 649 IVHPLWETWADLVHPDAQEILDTLEDN 675
+ +++ W H A ++ L DN
Sbjct: 820 FITDMFDAWDAFAHLPA--LMQHLADN 844
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 360 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 419
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 487 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 546
Query: 420 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 479
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 547 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 606
Query: 480 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 538
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 607 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 666
Query: 539 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 589
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 667 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 724
Query: 590 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 648
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 725 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 784
Query: 649 IVHPLWETWADLVHPDAQEILDTLEDN 675
+ +++ W H A ++ L DN
Sbjct: 785 FITDMFDAWDAFAHLPA--LMQHLADN 809
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 360 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 419
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 445 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 504
Query: 420 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 479
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 505 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 564
Query: 480 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 538
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 565 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 624
Query: 539 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 589
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 625 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 682
Query: 590 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 648
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 683 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 742
Query: 649 IVHPLWETWADLVHPDAQEILDTLEDN 675
+ +++ W H A ++ L DN
Sbjct: 743 FITDMFDAWDAFAHLPA--LMQHLADN 767
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 360 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 419
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 542 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 601
Query: 420 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 479
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 602 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 661
Query: 480 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 538
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 662 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 721
Query: 539 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 589
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 722 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 779
Query: 590 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 648
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 780 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 839
Query: 649 IVHPLWETWADLVHPDAQEILDTLEDN 675
+ +++ W H A ++ L DN
Sbjct: 840 FITDMFDAWDAFAHLPA--LMQHLADN 864
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 209 bits (533), Expect = 7e-54
Identities = 106/290 (36%), Positives = 168/290 (57%), Gaps = 8/290 (2%)
Query: 369 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 428
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
Query: 429 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 488
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
Query: 489 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 548
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 242 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 299
Query: 549 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 608
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 300 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 353
Query: 609 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWA 658
+ EFF QGD E++ + +SP+CD+HT S+ Q+GF+ Y+V PL+ WA
Sbjct: 354 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 194 bits (493), Expect = 3e-49
Identities = 100/281 (35%), Positives = 160/281 (56%), Gaps = 8/281 (2%)
Query: 369 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 428
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
Query: 429 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 488
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
Query: 489 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 548
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 268 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 325
Query: 549 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 608
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 326 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 379
Query: 609 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI 649
+ EFF QGD E++ + +SP+CD+HT S+ Q+G Y+
Sbjct: 380 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 178 bits (451), Expect = 2e-44
Identities = 110/337 (32%), Positives = 168/337 (49%), Gaps = 52/337 (15%)
Query: 369 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 425
+E ++ W IF + + G GR L+ +MY +FQ+ LL+ F+IP + Y LE+
Sbjct: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
Query: 426 YHADVAYHNSLHAADVLQSTHVLLATPA-------------------------------- 453
Y D+ YHN +HA DVL + L P
Sbjct: 731 YR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISS 789
Query: 454 ------------LDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 501
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SV
Sbjct: 790 KSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSV 849
Query: 502 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 560
LENHH A + L L + +L + + R +VI+ +LATD+ KH LA+
Sbjct: 850 LENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA-- 907
Query: 561 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 620
+ V S+G+ N +DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD E
Sbjct: 908 KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEE 966
Query: 621 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 657
G+ ISP D+ + + K Q FI +IV PL ++
Sbjct: 967 ANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (448), Expect = 5e-44
Identities = 101/328 (30%), Positives = 179/328 (54%), Gaps = 14/328 (4%)
Query: 353 PRFGVKTDQEELLAQE-LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIP 411
PR V T + LL+ E +E L K +++ + L+C+ +M + + L++ F I
Sbjct: 29 PRRDVPTYPKYLLSPETIEALRKPTFDVWL---WEPNEMLSCLEHM-YHDLGLVRDFSIN 84
Query: 412 VDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAA 471
T+ ++ + D+Y + +HN H V Q + ++ +L F+ +IL + AA
Sbjct: 85 PVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAI 143
Query: 472 IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQ 531
HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E C+IF N+ +
Sbjct: 144 CHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFK 203
Query: 532 SLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCAD 591
+R+ +I ++LATDM++H ++ K +E ++ + L + ++ C D
Sbjct: 204 QIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL--------LKMILIKCCD 255
Query: 592 LSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVH 651
+SN +P+E+ W D ++ E+F Q DRE+ G+ ++P D+ + +Q+GFI +++
Sbjct: 256 ISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLI 315
Query: 652 PLWETWADLVHPDAQEILDTLEDNRDWY 679
P++ET L + +L L ++RD Y
Sbjct: 316 PMFETVTKLFPMVEEIMLQPLWESRDRY 343
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (448), Expect = 5e-44
Identities = 101/328 (30%), Positives = 179/328 (54%), Gaps = 14/328 (4%)
Query: 353 PRFGVKTDQEELLAQE-LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIP 411
PR V T + LL+ E +E L K +++ + L+C+ +M + + L++ F I
Sbjct: 29 PRRDVPTYPKYLLSPETIEALRKPTFDVWL---WEPNEMLSCLEHM-YHDLGLVRDFSIN 84
Query: 412 VDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAA 471
T+ ++ + D+Y + +HN H V Q + ++ +L F+ +IL + AA
Sbjct: 85 PVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAI 143
Query: 472 IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQ 531
HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E C+IF N+ +
Sbjct: 144 CHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFK 203
Query: 532 SLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCAD 591
+R+ +I ++LATDM++H ++ K +E ++ + L + ++ C D
Sbjct: 204 QIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL--------LKMILIKCCD 255
Query: 592 LSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVH 651
+SN +P+E+ W D ++ E+F Q DRE+ G+ ++P D+ + +Q+GFI +++
Sbjct: 256 ISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLI 315
Query: 652 PLWETWADLVHPDAQEILDTLEDNRDWY 679
P++ET L + +L L ++RD Y
Sbjct: 316 PMFETVTKLFPMVEEIMLQPLWESRDRY 343
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,870,322
Number of Sequences: 37866
Number of extensions: 2093342
Number of successful extensions: 18150
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 166
Number of HSP's successfully gapped in prelim test: 297
Number of HSP's that attempted gapping in prelim test: 15736
Number of HSP's gapped (non-prelim): 2301
length of query: 886
length of database: 18,247,518
effective HSP length: 111
effective length of query: 775
effective length of database: 14,044,392
effective search space: 10884403800
effective search space used: 10884403800
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.