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Search of human proteins with 162138911
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
(1488 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens] 3066 0.0
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens] 1823 0.0
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens] 1083 0.0
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens] 1022 0.0
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens] 573 e-163
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr... 158 4e-38
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 153 1e-36
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 153 1e-36
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange... 147 6e-35
gi|4758968 cytohesin 3 [Homo sapiens] 147 6e-35
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 147 6e-35
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 147 6e-35
gi|7019505 cytohesin 4 [Homo sapiens] 139 2e-32
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti... 132 2e-30
gi|48928044 F-box only protein 8 [Homo sapiens] 107 9e-23
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens] 104 7e-22
gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo s... 91 8e-18
gi|33636768 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo s... 91 8e-18
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 90 2e-17
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 89 2e-17
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 89 2e-17
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens] 88 5e-17
gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens] 88 7e-17
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [... 86 2e-16
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ... 84 8e-16
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6... 84 8e-16
gi|11386183 WAS protein family, member 2 [Homo sapiens] 84 1e-15
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens] 83 2e-15
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre... 82 3e-15
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 82 5e-15
>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
Length = 1488
Score = 3066 bits (7950), Expect = 0.0
Identities = 1488/1488 (100%), Positives = 1488/1488 (100%)
Query: 1 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD 60
MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
Sbjct: 1 MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD 60
Query: 61 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE 120
LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
Sbjct: 61 LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE 120
Query: 121 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP 180
GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
Sbjct: 121 GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP 180
Query: 181 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE 240
GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
Sbjct: 181 GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE 240
Query: 241 NSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP 300
NSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP
Sbjct: 241 NSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP 300
Query: 301 ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ 360
ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ
Sbjct: 301 ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ 360
Query: 361 YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG 420
YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG
Sbjct: 361 YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG 420
Query: 421 ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN 480
ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN
Sbjct: 421 ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN 480
Query: 481 CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ 540
CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ
Sbjct: 481 CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ 540
Query: 541 GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS 600
GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS
Sbjct: 541 GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS 600
Query: 601 DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG 660
DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG
Sbjct: 601 DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG 660
Query: 661 PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS 720
PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS
Sbjct: 661 PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS 720
Query: 721 LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF 780
LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF
Sbjct: 721 LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF 780
Query: 781 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF 840
LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF
Sbjct: 781 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF 840
Query: 841 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV 900
QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV
Sbjct: 841 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV 900
Query: 901 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG 960
KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG
Sbjct: 901 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG 960
Query: 961 KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS 1020
KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS
Sbjct: 961 KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS 1020
Query: 1021 FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI 1080
FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI
Sbjct: 1021 FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI 1080
Query: 1081 AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL 1140
AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL
Sbjct: 1081 AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL 1140
Query: 1141 SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN 1200
SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN
Sbjct: 1141 SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN 1200
Query: 1201 SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG 1260
SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG
Sbjct: 1201 SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG 1260
Query: 1261 QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR 1320
QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
Sbjct: 1261 QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR 1320
Query: 1321 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA 1380
HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA
Sbjct: 1321 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA 1380
Query: 1381 HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL 1440
HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL
Sbjct: 1381 HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL 1440
Query: 1441 PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV 1488
PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
Sbjct: 1441 PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV 1488
>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
Length = 949
Score = 1823 bits (4722), Expect = 0.0
Identities = 906/906 (100%), Positives = 906/906 (100%)
Query: 246 SVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVAL 305
SVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVAL
Sbjct: 41 SVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVAL 100
Query: 306 RKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNK 365
RKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNK
Sbjct: 101 RKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNK 160
Query: 366 NFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHR 425
NFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHR
Sbjct: 161 NFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHR 220
Query: 426 LERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSG 485
LERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSG
Sbjct: 221 LERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSG 280
Query: 486 PMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEF 545
PMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEF
Sbjct: 281 PMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEF 340
Query: 546 WAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVD 605
WAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVD
Sbjct: 341 WAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVD 400
Query: 606 LSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPA 665
LSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPA
Sbjct: 401 LSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPA 460
Query: 666 PNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPP 725
PNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPP
Sbjct: 461 PNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPP 520
Query: 726 ATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTP 785
ATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTP
Sbjct: 521 ATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTP 580
Query: 786 VGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIR 845
VGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIR
Sbjct: 581 VGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIR 640
Query: 846 VQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERK 905
VQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERK
Sbjct: 641 VQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERK 700
Query: 906 MKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVL 965
MKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVL
Sbjct: 701 MKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVL 760
Query: 966 SLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSF 1025
SLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSF
Sbjct: 761 SLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSF 820
Query: 1026 PLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQE 1085
PLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQE
Sbjct: 821 PLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQE 880
Query: 1086 MEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLR 1145
MEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLR
Sbjct: 881 MEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLR 940
Query: 1146 DLSDAG 1151
DLSDAG
Sbjct: 941 DLSDAG 946
Score = 38.9 bits (89), Expect = 0.037
Identities = 55/193 (28%), Positives = 65/193 (33%), Gaps = 43/193 (22%)
Query: 1280 PPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRP 1339
P P + PS PPPQ P PA PPV P PVP G
Sbjct: 320 PQQSPERLPSTEPPPQGRPEF-------WAPAPLPPVPP--------PVPSGTRED-GSR 363
Query: 1340 GRAPRRGAG--GHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMM 1397
RRG G F H LPL + P + + S H Q++
Sbjct: 364 EEGTRRGPGCLECRDFRLRAAH--------LPLLTIEPPSDSSVDLSDRSDRGSVHRQLV 415
Query: 1398 PAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSP 1457
A P G+ H P +PI PH YP P+P P PLPP
Sbjct: 416 YEADGCS------PHGTLKHKGPP-----GRAPI-PHRHYPAPEGPAP-APPGPLPP--- 459
Query: 1458 HGPLHASGPPGTA 1470
P +GP G A
Sbjct: 460 -APNSGTGPSGVA 471
Score = 35.0 bits (79), Expect = 0.54
Identities = 41/159 (25%), Positives = 52/159 (32%), Gaps = 34/159 (21%)
Query: 1175 RPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLF-GSKRGKGPFQ-------------- 1219
RP P P PP PP PV + + GS G++RG G +
Sbjct: 337 RPEFWAPAPLPPVPP-------PVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLL 389
Query: 1220 -MPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPA 1278
+ PP S S G H L DG S L + G P
Sbjct: 390 TIEPPSDSSVDLSDRS-----------DRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPI 438
Query: 1279 PPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVG 1317
P + P + P PP PP P G+ P A +G
Sbjct: 439 PHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLG 477
>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
Length = 1114
Score = 1083 bits (2802), Expect = 0.0
Identities = 657/1199 (54%), Positives = 789/1199 (65%), Gaps = 152/1199 (12%)
Query: 243 RTVSVEGDAPGSDLSTAVDSPGSQPPYRL----SQLPPSSSHMGGPPAGV--GLPWAQ-- 294
R VEG+AP S+ T++DSP + P L S P H G+ G P Q
Sbjct: 5 RRYFVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQR 64
Query: 295 --RARLQPASVALRKQEEEE-IKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAA 351
R +LQ ++ LRKQ EEE IKRS++LS+SYELS+DLQDK+VEMLERKYGG ++R AA
Sbjct: 65 TRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAA 124
Query: 352 RTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPA 411
RTIQTAFRQY+MNKNFERLRSS SE+RMSRRI+LSNMRMQFSFE EK + +YFEGK
Sbjct: 125 RTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHS-SYFEGKQV 183
Query: 412 SL-DEGAMAGARSHRLERGLPYGGSCGGGIDGGG-SSVTTSGEFSNDITELEDSFSKQVK 469
S+ ++G+ GA CG + S S +F++ ITELED+FS+QVK
Sbjct: 184 SVTNDGSQLGAL---------VSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVK 234
Query: 470 SLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQE---------DSSATSFSDLPLYL 520
SLAESID+ALNC S E P R+++ Q D S+SD+ LY+
Sbjct: 235 SLAESIDDALNCR-SLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYI 293
Query: 521 DDT-----VP-QQSPERLPSTEPPPQGR-----PEFWAPAPLPPVPPPVPSGTREDGSRE 569
D+ +P Q+ +R STE + R P++WA A +ED +
Sbjct: 294 DEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAH------------KEDKADT 341
Query: 570 EGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPH 629
+ + R LE ++ RLR HLPLLTIEPPSDSSVDLSDRS+RGS+ RQ YE
Sbjct: 342 DTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQ 401
Query: 630 GTLKHKGPPGRAPIPHRHYPAPEGPA-PAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAG 688
G+ KH GP AP + P E P PP PL +S +G A R K E+
Sbjct: 402 GSPKH-GPHSGAP---KSLPREEPELRPRPPRPL----DSHLAINGSAN--RQSKSES-- 449
Query: 689 ENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFN 748
+ SDG DN+S+ S+SNSN+TINCSS SSSRDSLRE L KQTY +E R+SWDSPAF+
Sbjct: 450 DYSDG-DNDSINSTSNSNDTINCSSESSSRDSLREQT---LSKQTYHKEARNSWDSPAFS 505
Query: 749 NDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLG 808
NDV+++RHYRIGLNLFNKKPEKG+QYLIERGF+ DTPVGVAHF+L+RKGLSRQMIGEFLG
Sbjct: 506 NDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLG 565
Query: 809 NRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCN 868
NRQKQFNRDVLDCVVDEMDFS+M+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQRYC+CN
Sbjct: 566 NRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICN 625
Query: 869 PALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDL 928
P +VRQFRNPDTIFILAFAIILLNTDMYSP+VK ERKMKL+DFIKNLRGVD+GEDIPR++
Sbjct: 626 PGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREM 685
Query: 929 LVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKP----------VLSLPHRRLVCCCQL 978
L+GIY+RI+ REL+TN+DHVSQVQ VE++IVGKKP VLSLPHRRLVC C+L
Sbjct: 686 LMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRL 745
Query: 979 YEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNS 1038
+EVPDPN+PQ+LGLHQRE+FLFNDLLVVTKIFQKKK VTYSFRQSF L M + LF+N
Sbjct: 746 FEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQ 805
Query: 1039 YYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQ 1098
YY GI+L S+VPG + KVLI FNAP+ QDR +FT DLRESIAEVQEMEK+R+ESELEKQ
Sbjct: 806 YYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQ 865
Query: 1099 KGMMRPNASQPGG-AKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRN 1157
KG++RP+ SQ K+S NGT++R+ L+D+Y +G+GLKR ALSSSLRDLS+AGKRGRR+
Sbjct: 866 KGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRS 925
Query: 1158 SVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGP 1217
S GSL+S +EGS+ISSP +R P + + + NSSS LGSLFGSKRGK
Sbjct: 926 SAGSLESNVEGSIISSPHMRRRATSTRECPS----RPHQTMPNSSSLLGSLFGSKRGK-- 979
Query: 1218 FQMPPPPTGQASASSSSASSTHH------HHHHHHHGHSHGGLGVLPDGQSKLQALHAQY 1271
PPP QA S+ A H H H GH G LP Q+ + H QY
Sbjct: 980 ---PPP---QAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGPPEGLP--QAAMHGHHTQY 1031
Query: 1272 CQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGP--VP 1329
C PPPY H H H H P +
Sbjct: 1032 CHMQN--PPPY------------------------------------HHHHHHHPPQHIQ 1053
Query: 1330 GPQHYTLGRPGRAPRRGAGGH---PQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGP 1385
Y G G P GA H P + H H +H P PAP P + K P
Sbjct: 1054 HAHQYHHGPHGGHPAYGAHAHGHPPLPSAHVGHTVHHHGQP-----PAPPPPTSSKAKP 1107
>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
Length = 963
Score = 1022 bits (2643), Expect = 0.0
Identities = 586/966 (60%), Positives = 706/966 (73%), Gaps = 84/966 (8%)
Query: 247 VEGDAPGSDLSTAVDSPGSQPPYRL----SQLPPSSSHMGGPPAGV--GLPWAQ----RA 296
VEG+AP S+ T++DSP + P L S P H G+ G P Q R
Sbjct: 23 VEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRP 82
Query: 297 RLQPASVALRKQEEEE-IKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQ 355
+LQ ++ LRKQ EEE IKRS++LS+SYELS+DLQDK+VEMLERKYGG ++R AARTIQ
Sbjct: 83 KLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQ 142
Query: 356 TAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASL-D 414
TAFRQY+MNKNFERLRSS SE+RMSRRI+LSNMRMQFSFE EK + +YFEGK S+ +
Sbjct: 143 TAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHS-SYFEGKQVSVTN 201
Query: 415 EGAMAGARSHRLERGLPYGGSCGGGIDGGG-SSVTTSGEFSNDITELEDSFSKQVKSLAE 473
+G+ GA CG + S S +F++ ITELED+FS+QVKSLAE
Sbjct: 202 DGSQLGAL---------VSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAE 252
Query: 474 SIDEALNCHPSGPMSEEPGSAQLEKRESKEQQE---------DSSATSFSDLPLYLDDT- 523
SID+ALNC S E P R+++ Q D S+SD+ LY+D+
Sbjct: 253 SIDDALNCR-SLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEE 311
Query: 524 ----VP-QQSPERLPSTEPPPQGR-----PEFWAPAPLPPVPPPVPSGTREDGSREEGTR 573
+P Q+ +R STE + R P++WA A +ED + + +
Sbjct: 312 LSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAH------------KEDKADTDTSC 359
Query: 574 RGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLK 633
R LE ++ RLR HLPLLTIEPPSDSSVDLSDRS+RGS+ RQ YE G+ K
Sbjct: 360 RSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPK 419
Query: 634 HKGPPGRAPIPHRHYPAPEGPA-PAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSD 692
H GP AP + P E P PP PL +S +G A R K E+ + SD
Sbjct: 420 H-GPHSGAP---KSLPREEPELRPRPPRPL----DSHLAINGSAN--RQSKSES--DYSD 467
Query: 693 GGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVV 752
G DN+S+ S+SNSN+TINCSS SSSRDSLRE L KQTY +E R+SWDSPAF+NDV+
Sbjct: 468 G-DNDSINSTSNSNDTINCSSESSSRDSLREQT---LSKQTYHKEARNSWDSPAFSNDVI 523
Query: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812
++RHYRIGLNLFNKKPEKG+QYLIERGF+ DTPVGVAHF+L+RKGLSRQMIGEFLGNRQK
Sbjct: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583
Query: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872
QFNRDVLDCVVDEMDFS+M+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQRYC+CNP +V
Sbjct: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643
Query: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932
RQFRNPDTIFILAFAIILLNTDMYSP+VK ERKMKL+DFIKNLRGVD+GEDIPR++L+GI
Sbjct: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703
Query: 933 YQRIQGRELRTNDDHVSQVQAVERMIVGKKP----------VLSLPHRRLVCCCQLYEVP 982
Y+RI+ REL+TN+DHVSQVQ VE++IVGKKP VLSLPHRRLVC C+L+EVP
Sbjct: 704 YERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVP 763
Query: 983 DPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQF 1042
DPN+PQ+LGLHQRE+FLFNDLLVVTKIFQKKK VTYSFRQSF L M + LF+N YY
Sbjct: 764 DPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPN 823
Query: 1043 GIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMM 1102
GI+L S+VPG + KVLI FNAP+ QDR +FT DLRESIAEVQEMEK+R+ESELEKQKG++
Sbjct: 824 GIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVV 883
Query: 1103 RPNASQPGG-AKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGS 1161
RP+ SQ K+S NGT++R+ L+D+Y +G+GLKR ALSSSLRDLS+AGKRGRR+S GS
Sbjct: 884 RPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGS 943
Query: 1162 LDSTIE 1167
L+S +E
Sbjct: 944 LESNVE 949
>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
Length = 759
Score = 573 bits (1476), Expect = e-163
Identities = 360/777 (46%), Positives = 457/777 (58%), Gaps = 94/777 (12%)
Query: 336 MLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFE 395
MLE KYGG +SRRAA TIQTAFRQY+++KNFE++R+S ESR+ RRI L
Sbjct: 1 MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISL---------- 50
Query: 396 EYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYG-GSCGGGIDGGGSSVTTSGEFS 454
K ++P A S E+ L G G G + S T F+
Sbjct: 51 --RKVRSPT----------------AESLAAEKALMEGYGLVGLPLVRSPSLPPT---FA 89
Query: 455 NDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFS 514
+TELEDSF++QV+SLA+SID+AL+ M RES Q + + +
Sbjct: 90 GTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCS--------LRESGAYQLHQALQAAA 141
Query: 515 DLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRR 574
P ++ R P + P G A P PP SGT
Sbjct: 142 GPP-------GLEAEGRAPESAGPGPGDD-----AAETPGLPPAHSGTL----------- 178
Query: 575 GPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKH 634
+ RD ++ A+ + SS LS + G+ Q E G +
Sbjct: 179 ---MMAFRDVTVQIANQNISV-----SSSTALSVANCLGAQTVQAPAEPAA----GKAEQ 226
Query: 635 KGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCE--------- 685
GR APE PA + SG A G K E
Sbjct: 227 GETSGRE--------APEAPAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETA 278
Query: 686 --AAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWD 743
G ++ GD E L SSS S ++ S +S+ S A L Y E S
Sbjct: 279 EVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCK 338
Query: 744 SPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMI 803
SP + D +++R YRIGLNLFN P+KGIQ+LI RGF+ DTP+GVAHF+L+RKGLSRQMI
Sbjct: 339 SPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMI 398
Query: 804 GEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQR 863
GEFLGN +KQFNRDVLDCVVDEMDFSSM+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQR
Sbjct: 399 GEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQR 458
Query: 864 YCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGED 923
YC+CNP +V+QF NPDTIFILAFAIILLNTDMYSP++K +RKM L+DFI+NLRGVD+G D
Sbjct: 459 YCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGAD 518
Query: 924 IPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPD 983
IPR+L+VGIY+RIQ +EL++N+DHV+ V VE+ IVG K VLS+PHRRLVCC +L+EV D
Sbjct: 519 IPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTD 578
Query: 984 PNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFG 1043
N+ Q+ HQREVFLFNDLLV+ K+ KKK TY+F +S L+ M QLF+N YY G
Sbjct: 579 VNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHG 638
Query: 1044 IKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKG 1100
I L++ + G E+K ++ F A + +F DL+ESIAEV E+E+ R+E ELEKQ+G
Sbjct: 639 ITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQG 695
>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
protein 1 [Homo sapiens]
Length = 1849
Score = 158 bits (399), Expect = 4e-38
Identities = 91/235 (38%), Positives = 139/235 (59%), Gaps = 9/235 (3%)
Query: 707 ETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNK 766
ETIN S +SL ++G+ +Y + + + F Q+ G++LFNK
Sbjct: 657 ETIN---RYGSLNSLESTSSSGI--GSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNK 711
Query: 767 KPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEM 826
KP++GIQYL E+G L TP +A F+ + + L +GEFLG+ K FN++V+ VD+
Sbjct: 712 KPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDK-FNKEVMYAYVDQH 770
Query: 827 DFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAF 886
DFS D ALR F R+ GEAQK++RL+E F+ RY CN F + DT ++LA+
Sbjct: 771 DFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQT-LFASADTAYVLAY 829
Query: 887 AIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGREL 941
+II+L TD++SP VK KM + +IK RG+++ +D+P + L IY I G+++
Sbjct: 830 SIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKI 882
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 153 bits (386), Expect = 1e-36
Identities = 76/194 (39%), Positives = 127/194 (65%), Gaps = 6/194 (3%)
Query: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812
+ R +G FN P+KGIQ+L+E L +TP +A F+ + +GL++ IG++LG R+
Sbjct: 61 RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE- 119
Query: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872
+ N VL VD +F+ ++L ALR+F R+ GEAQK++R++EAF+QRYC+CNP +
Sbjct: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178
Query: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932
F++ DT ++L+FA+I+LNT +++P+V+ K L+ F+ RG++ G D+P +LL +
Sbjct: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVR--DKPGLERFVAMNRGINEGGDLPEELLRNL 234
Query: 933 YQRIQGRELRTNDD 946
Y I+ + +D
Sbjct: 235 YDSIRNEPFKIPED 248
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 153 bits (386), Expect = 1e-36
Identities = 76/194 (39%), Positives = 127/194 (65%), Gaps = 6/194 (3%)
Query: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812
+ R +G FN P+KGIQ+L+E L +TP +A F+ + +GL++ IG++LG R+
Sbjct: 61 RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE- 119
Query: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872
+ N VL VD +F+ ++L ALR+F R+ GEAQK++R++EAF+QRYC+CNP +
Sbjct: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178
Query: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932
F++ DT ++L+FA+I+LNT +++P+V+ K L+ F+ RG++ G D+P +LL +
Sbjct: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVR--DKPGLERFVAMNRGINEGGDLPEELLRNL 234
Query: 933 YQRIQGRELRTNDD 946
Y I+ + +D
Sbjct: 235 YDSIRNEPFKIPED 248
>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
factor 2 [Homo sapiens]
Length = 1785
Score = 147 bits (372), Expect = 6e-35
Identities = 73/182 (40%), Positives = 119/182 (65%), Gaps = 4/182 (2%)
Query: 760 GLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVL 819
G+ LFNKKP++GIQ+L E+G L + +A F+ + + L +G+FLG+ + FN++V+
Sbjct: 650 GIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSAR-FNKEVM 708
Query: 820 DCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPD 879
VD++DF + ALR F R+ GEAQK++RL+E F+ RY CN F + D
Sbjct: 709 YAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT-LFASAD 767
Query: 880 TIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGR 939
T ++LA++II+L TD++SP VK KM + +IK RG+++ +D+P + L IY+ I+G+
Sbjct: 768 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGK 825
Query: 940 EL 941
++
Sbjct: 826 KI 827
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 147 bits (372), Expect = 6e-35
Identities = 75/194 (38%), Positives = 125/194 (64%), Gaps = 6/194 (3%)
Query: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812
+ + +G FN P+KGIQ+LIE L +P VA F+ + +GL++ +IG++LG R
Sbjct: 66 RNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERD- 124
Query: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872
+FN VL V+ +F+ ++L ALR+F R+ GEAQK++R++EAF+ RYC+CNP +
Sbjct: 125 EFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGV- 183
Query: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932
F++ DT ++L+FAII+LNT +++ +V+ K + FI RG++ G D+P +LL +
Sbjct: 184 --FQSTDTCYVLSFAIIMLNTSLHNHNVR--DKPTAERFIAMNRGINEGGDLPEELLRNL 239
Query: 933 YQRIQGRELRTNDD 946
Y+ I+ + +D
Sbjct: 240 YESIKNEPFKIPED 253
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 147 bits (372), Expect = 6e-35
Identities = 76/194 (39%), Positives = 126/194 (64%), Gaps = 6/194 (3%)
Query: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812
+ + +G FN P+KGIQ+LIE L +T +A F+ + +GL++ IG++LG R
Sbjct: 62 RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
Query: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872
+FN VL V+ +F+ ++L ALR+F R+ GEAQK++R++EAF+QRYC CN +
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
Query: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932
F++ DT ++L+FAII+LNT +++P+VK K ++ FI RG+++G D+P +LL +
Sbjct: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVK--DKPTVERFIAMNRGINDGGDLPEELLRNL 235
Query: 933 YQRIQGRELRTNDD 946
Y+ I+ + +D
Sbjct: 236 YESIKNEPFKIPED 249
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 147 bits (372), Expect = 6e-35
Identities = 76/194 (39%), Positives = 126/194 (64%), Gaps = 6/194 (3%)
Query: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812
+ + +G FN P+KGIQ+LIE L +T +A F+ + +GL++ IG++LG R
Sbjct: 62 RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
Query: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872
+FN VL V+ +F+ ++L ALR+F R+ GEAQK++R++EAF+QRYC CN +
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
Query: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932
F++ DT ++L+FAII+LNT +++P+VK K ++ FI RG+++G D+P +LL +
Sbjct: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVK--DKPTVERFIAMNRGINDGGDLPEELLRNL 235
Query: 933 YQRIQGRELRTNDD 946
Y+ I+ + +D
Sbjct: 236 YESIKNEPFKIPED 249
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 139 bits (351), Expect = 2e-32
Identities = 72/188 (38%), Positives = 116/188 (61%), Gaps = 6/188 (3%)
Query: 759 IGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDV 818
IG FN P KGIQY IE L+ +A F+ + +GL++ IG +LG R N V
Sbjct: 67 IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP-INLQV 125
Query: 819 LDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNP 878
L VD +F++++L ALR+F R+ GEAQK++R++EAF+ RYC+CNP + F++
Sbjct: 126 LQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV---FQST 182
Query: 879 DTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQG 938
DT ++L+F+II+LNT +++P+V+ + + F+ RG++NG D+P D L ++ I+
Sbjct: 183 DTCYVLSFSIIMLNTSLHNPNVR--DRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240
Query: 939 RELRTNDD 946
+D
Sbjct: 241 EPFSIPED 248
>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
exchange factor 1 [Homo sapiens]
Length = 1859
Score = 132 bits (333), Expect = 2e-30
Identities = 85/246 (34%), Positives = 138/246 (56%), Gaps = 14/246 (5%)
Query: 714 GSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRI---GLNLFNKKPEK 770
G S L E +G K+ ++ R S P + + ++ G FN+KP+K
Sbjct: 657 GKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKK 716
Query: 771 GIQYLIERGFLSDTPVG---VAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMD 827
GIQ+L E+G L+ P+ VA ++ E L ++MIGEF+ +R+ N D+L+ V
Sbjct: 717 GIQFLQEKGLLT-IPMDNTEVAQWLRENPRLDKKMIGEFVSDRK---NIDLLESFVSTFS 772
Query: 828 FSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFA 887
F + LD+ALR + R+ GEA ++RL+EAF++R+ CN + F N D F LA+A
Sbjct: 773 FQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGS---PFANSDACFSLAYA 829
Query: 888 IILLNTDMYSPSV-KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDD 946
+I+LNTD ++ +V K M L++F KNL+GV+ G+D +D+L +Y I+ E+ ++
Sbjct: 830 VIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEE 889
Query: 947 HVSQVQ 952
V+
Sbjct: 890 QTGLVR 895
Score = 33.1 bits (74), Expect = 2.1
Identities = 42/142 (29%), Positives = 48/142 (33%), Gaps = 34/142 (23%)
Query: 1353 FAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPG 1412
F PH R L + T + P P P QG K +H + AAG PG PP
Sbjct: 1708 FLPHLRDELFKQTV---IQDPMPMEP----QGQKPLASAH---LTSAAGDTRTPGHPPP- 1756
Query: 1413 GSYSHPHHP--------QSPLSPHSPIPPHPSYPPLPPPS--PHTPHSPLPPTSP----- 1457
P P + P SP + P P PS TP P P P
Sbjct: 1757 -----PEIPSELGACDFEKPESPRAASSSSPGSPVASSPSRLSPTPDGPPPLAQPPLILQ 1811
Query: 1458 --HGPLHASGPPGTANPPSANP 1477
PL PP T P NP
Sbjct: 1812 PLASPLQVGVPPMTL-PIILNP 1832
Score = 32.0 bits (71), Expect = 4.6
Identities = 28/91 (30%), Positives = 31/91 (34%), Gaps = 31/91 (34%)
Query: 1258 PDGQSKLQALHAQYCQG----PGPAPPPYLP----------PQQPS-------------- 1289
P GQ L + H G PG PPP +P P+ P
Sbjct: 1730 PQGQKPLASAHLTSAAGDTRTPGHPPPPEIPSELGACDFEKPESPRAASSSSPGSPVASS 1789
Query: 1290 ---LPPPPQQPPPLPQLGSIPPPPASAPPVG 1317
L P P PPPL Q I P AS VG
Sbjct: 1790 PSRLSPTPDGPPPLAQPPLILQPLASPLQVG 1820
>gi|48928044 F-box only protein 8 [Homo sapiens]
Length = 319
Score = 107 bits (267), Expect = 9e-23
Identities = 72/214 (33%), Positives = 116/214 (54%), Gaps = 17/214 (7%)
Query: 728 GLCKQTYQRETRHSWDSP---AFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDT 784
GLCK T+ + ++ + P +F +Q G FN P++G+ Y + +G L D+
Sbjct: 110 GLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDE---GSLTFNANPDEGVNYFMSKGILDDS 166
Query: 785 PVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHI 844
P +A FI + L+ + + +L R RDVLD +V +F + L +ALR+F HI
Sbjct: 167 PKEIAKFIFCTRTLNWKKLRIYLDER-----RDVLDDLVTLHNFRNQFLPNALREFFRHI 221
Query: 845 RVQGE-AQKVERLIEAFSQRYCVCNPALVRQF-RNPDTIFILAFAIILLNTDMYSPSVKA 902
E + +E LI FS R+C CNP L+R+ +PD +++L +++ILL+ D+ SP VK
Sbjct: 222 HAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVK- 280
Query: 903 ERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRI 936
KM +FI+N R ++I D + +Y I
Sbjct: 281 -NKMSKREFIRNTRRA--AQNISEDFVGHLYDNI 311
>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
Length = 1024
Score = 104 bits (259), Expect = 7e-22
Identities = 113/433 (26%), Positives = 177/433 (40%), Gaps = 59/433 (13%)
Query: 530 ERLPSTEPPP-QGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPG--CLECRDFRL 586
E PS+E PP P P PLP P + SG ++ E G E +
Sbjct: 316 ESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGAR 375
Query: 587 RAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYE---ADGCS--PHGTLKHKGPPGRA 641
+ +PL + P + +D D S + + E A G S +L+ PG
Sbjct: 376 PGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPT 435
Query: 642 PIPHRHY---PAPEGPAPAPPGPLPPAP---NSGTGPSGVAGGRRLGKCEAAGENSDGGD 695
P + P P P P PP P P AP +SGT + + G+ E A +
Sbjct: 436 QSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAP 495
Query: 696 NESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRR 755
S +S +++ + EPP + L + ++++
Sbjct: 496 GREPPSPCHSEDSLGLGAAPLGS----EPPLSQLVSDS--------------DSELDSTE 537
Query: 756 HYRIG----LNLFNKKPEKGIQYLIERGFLSD--TPVGVAHFILERKGLSRQMIGEFLGN 809
+G L+ K + Q L +R + D VA + + S+ + GE+L
Sbjct: 538 RLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYL-- 595
Query: 810 RQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNP 869
K F F+ M LD ALR F + + GE Q+ ER++ FSQRY CNP
Sbjct: 596 --KFFV------------FTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNP 641
Query: 870 ALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLL 929
+ D L A++LLNTD++ ++ ++M DFI NL G+++G D PR+LL
Sbjct: 642 ---EALSSEDGAHTLTCALMLLNTDLHGHNI--GKRMTCGDFIGNLEGLNDGGDFPRELL 696
Query: 930 VGIYQRIQGRELR 942
+Y I+ +L+
Sbjct: 697 KALYSSIKNEKLQ 709
Score = 41.6 bits (96), Expect = 0.006
Identities = 54/190 (28%), Positives = 66/190 (34%), Gaps = 31/190 (16%)
Query: 1309 PPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRG-AGGHPQF-----------APH 1356
PP +A P P GP+PGP H +LG AGG P
Sbjct: 324 PPGTAYPPAPRP-----GPLPGP-HPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPG 377
Query: 1357 GRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYS 1416
R PL P LP SP+ P + + + SH + A PG +
Sbjct: 378 SRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPT-- 435
Query: 1417 HPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGP---PGTANPP 1473
QSP +PP P P PP+P P +PL P S A GP G
Sbjct: 436 -----QSPFFTFE-LPPQPPAPRPDPPAP-APLAPLEPDSGTSSA-ADGPWTQRGEEEEA 487
Query: 1474 SANPKAKPSR 1483
A K P R
Sbjct: 488 EARAKLAPGR 497
Score = 35.0 bits (79), Expect = 0.54
Identities = 73/309 (23%), Positives = 101/309 (32%), Gaps = 55/309 (17%)
Query: 1046 LLSAVPGG----ERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGM 1101
L S++P G ++ +F P+ L D S EV + ++ E G
Sbjct: 188 LYSSLPNGLGGPPERLATLFGGPADTGFLN-QGDTWSSPREVSSHAQRIARAKWEFFYGS 246
Query: 1102 MRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSV-- 1159
+ P +S GAK + + G+G + R A S DL R R +
Sbjct: 247 LDPPSS---GAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSET-DLDTVPLRCYRETDID 302
Query: 1160 ------GSLDSTIEGSVISSPRPHQRMPPPPPPPP----------PEEYKSQRPVSNSSS 1203
DS IE S P PP P P P E +
Sbjct: 303 EVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGEED 362
Query: 1204 FLGSLFGSKRGKGPFQMPP--------PPTGQASASSSSASSTHHH--HHHHHHGHSHGG 1253
+F + G P P P T ++ S S H G S+
Sbjct: 363 VDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSYTS 422
Query: 1254 LGVLPDGQSKLQALHAQYCQGPGPAPPPY----LPPQQPSLPPPPQQPPPLPQLGSIPPP 1309
L + L+AL + PGP P+ LPPQ P+ P P P PL L P
Sbjct: 423 L-------ASLEALAS-----PGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLE--PDS 468
Query: 1310 PASAPPVGP 1318
S+ GP
Sbjct: 469 GTSSAADGP 477
Score = 35.0 bits (79), Expect = 0.54
Identities = 46/153 (30%), Positives = 61/153 (39%), Gaps = 23/153 (15%)
Query: 484 SGPMSEEPGSAQ--LEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEP-PPQ 540
+ P ++ P S E + + +S TS + L L P QSP P PP
Sbjct: 392 TSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEA-LASPGPTQSPFFTFELPPQPPA 450
Query: 541 GRPEFWAPAPLPPVPPPVPSGTRED------GSREEGTRR---GPG------CLECRDFR 585
RP+ APAPL P+ P + + D G EE R PG C
Sbjct: 451 PRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLG 510
Query: 586 LRAAHL----PLLTIEPPSDSSVDLSDRSDRGS 614
L AA L PL + SDS +D ++R GS
Sbjct: 511 LGAAPLGSEPPLSQLVSDSDSELDSTERLALGS 543
Score = 31.6 bits (70), Expect = 6.0
Identities = 36/125 (28%), Positives = 41/125 (32%), Gaps = 34/125 (27%)
Query: 1347 AGGHPQFAPHGRHPLHQPTSP---LPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAA 1403
A G +F G + P P LP P PQ PPA G +
Sbjct: 2 AQGAMRFCSEGDCAISPPRCPRRWLP-EGPVPQSPPASMYGSTGSLLRR----------V 50
Query: 1404 GGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHA 1463
GPG P G P +PL PPSP SP P+SP G
Sbjct: 51 AGPG--PRGRELGRVTAPCTPLRG--------------PPSPRVAPSPWAPSSPTG---- 90
Query: 1464 SGPPG 1468
PPG
Sbjct: 91 QPPPG 95
>gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
sapiens]
Length = 1858
Score = 90.9 bits (224), Expect = 8e-18
Identities = 99/323 (30%), Positives = 119/323 (36%), Gaps = 66/323 (20%)
Query: 1181 PPPPPPPPPEE--YKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASST 1238
PPPPPPPPP Y++Q+P +N ++ L GS + F P QA ++S +
Sbjct: 1544 PPPPPPPPPSSSYYQNQQPSANFQNY-NQLKGSLSQQTVFTSGP---NQALPGTTSQQTV 1599
Query: 1239 HHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPP 1298
HH H LP S+ +H Q P PPP PP P P Q P
Sbjct: 1600 PGHHVTPGH--------FLP---SQNPTIHHQTAAAVVPPPPP--PPPAPG--PHLVQQP 1644
Query: 1299 PLPQLGSIPPPPASAPPVGPHRHFHA-----HGPVPGPQHYTLGRPGRAPRRGAGGHPQF 1353
Q S+ V P H H+ H P P P PG AP HP
Sbjct: 1645 NSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPP------PGPAPHHHPPPHPST 1698
Query: 1354 APHGRHPLHQ---PTSPLPLYSPAPQ---------------HPPAHKQGPKHFIFSHHPQ 1395
G HQ ++P P P P H P H QGP F S HP
Sbjct: 1699 GLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPH-QGPPLFPSSAHPT 1757
Query: 1396 MMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIP---PH-----PSYPPLPPPSPHT 1447
+ P A + PG P H S PH P+P PH P+ P P S
Sbjct: 1758 VPPYPSQATHHTTLGPG-----PQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFC 1812
Query: 1448 PH--SPLPPTSPHGPLHASGPPG 1468
PH S P GP AS PG
Sbjct: 1813 PHPGSVALPHGVQGPQQASPVPG 1835
Score = 63.2 bits (152), Expect = 2e-09
Identities = 67/240 (27%), Positives = 81/240 (33%), Gaps = 47/240 (19%)
Query: 1159 VGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKR---GK 1215
VG + + GS I S +PPPPPPP P + P + S+ L L +
Sbjct: 1656 VGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPH--HHPPPHPSTGLQGLQAQHQHVVNS 1713
Query: 1216 GPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGP 1275
P PPPP AS +S HH H G
Sbjct: 1714 APPPPPPPPPSSVLASGHHTTSAQALHHPPHQG--------------------------- 1746
Query: 1276 GPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYT 1335
PP + P++PP P Q LG P P GPH PV GP H
Sbjct: 1747 ---PPLFPSSAHPTVPPYPSQATHHTTLG--PGPQHQPSGTGPHCPL----PVTGP-HLQ 1796
Query: 1336 LGRPGRAPRRGAGGHPQFAPH-GRHPLHQPTSPLPLYSPAPQHPPAHK-QGPKHFIFSHH 1393
P P A G F PH G L SP P P H+ Q P F ++H
Sbjct: 1797 PQGPNSIPTPTASG---FCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYH 1853
Score = 55.1 bits (131), Expect = 5e-07
Identities = 87/345 (25%), Positives = 110/345 (31%), Gaps = 64/345 (18%)
Query: 1174 PRPHQRMPPP---PPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASA 1230
P PH PP P P Y S +P S LGS + Q P T Q
Sbjct: 1443 PSPHLENPPKSSTPHTPVQHGYLSPKPPSQQ---LGSPYRPHHS----QSPQVGTPQREP 1495
Query: 1231 SSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSL 1290
+ + + + S P GQS A ++Q+ Q +
Sbjct: 1496 QRNFYPAAQNLPANTQQATSGTLFTQTPSGQSS--ATYSQFNQ----------QSLNSTA 1543
Query: 1291 PPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGR----PGRAPRRG 1346
PPPP PPP P A+ + G + +T G PG ++
Sbjct: 1544 PPPPPPPPPSSSYYQNQQPSANF-----QNYNQLKGSLSQQTVFTSGPNQALPGTTSQQT 1598
Query: 1347 AGGHP----QFAPHGRHPLHQPTS-----PLPLYSPAP------------QHPPAHKQGP 1385
GH F P +H T+ P P PAP QH AH GP
Sbjct: 1599 VPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGP 1658
Query: 1386 KHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSH--PHHPQSPLSPHSPIPPHPSYPPLPPP 1443
H + AG P PPG + H P HP + L H PPP
Sbjct: 1659 VHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPP 1718
Query: 1444 SPHTP-------HSPLPPTSPHGPLHASGPPGTANPPSANPKAKP 1481
P P H + H P H GPP P SA+P P
Sbjct: 1719 PPPPPSSVLASGHHTTSAQALHHPPH-QGPP--LFPSSAHPTVPP 1760
Score = 48.9 bits (115), Expect = 4e-05
Identities = 69/272 (25%), Positives = 97/272 (35%), Gaps = 37/272 (13%)
Query: 1230 ASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPS 1289
++++ A S +H H S LP +KL + + + P + P+ P Q
Sbjct: 1405 SNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGY 1464
Query: 1290 LPPPPQQPPPLPQLGS-IPPPPASAPPVG-----PHRHFH--AHGPVPGPQHYTLGRPGR 1341
L P PP QLGS P + +P VG P R+F+ A Q T G
Sbjct: 1465 LSP----KPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFT 1520
Query: 1342 APRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAG 1401
G ++ + L+ T+P P P P Q P F ++ Q+ +
Sbjct: 1521 QTPSGQSS-ATYSQFNQQSLNS-TAPPPPPPPPPSSSYYQNQQPS-ANFQNYNQLKGSLS 1577
Query: 1402 A----AGGPGSRPPG--------GSYSHPHH---PQSPLSPH----SPIPPHPSYPPLPP 1442
GP PG G + P H Q+P H + +PP P PP P
Sbjct: 1578 QQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPP--PPPPA 1635
Query: 1443 PSPHTPHSPLPPTSPHGPLHASGPPGTANPPS 1474
P PH P H H GP P S
Sbjct: 1636 PGPHLVQQP-NSHQQHSVAHVVGPVHAVTPGS 1666
>gi|33636768 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
sapiens]
Length = 1858
Score = 90.9 bits (224), Expect = 8e-18
Identities = 99/323 (30%), Positives = 119/323 (36%), Gaps = 66/323 (20%)
Query: 1181 PPPPPPPPPEE--YKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASST 1238
PPPPPPPPP Y++Q+P +N ++ L GS + F P QA ++S +
Sbjct: 1544 PPPPPPPPPSSSYYQNQQPSANFQNY-NQLKGSLSQQTVFTSGP---NQALPGTTSQQTV 1599
Query: 1239 HHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPP 1298
HH H LP S+ +H Q P PPP PP P P Q P
Sbjct: 1600 PGHHVTPGH--------FLP---SQNPTIHHQTAAAVVPPPPP--PPPAPG--PHLVQQP 1644
Query: 1299 PLPQLGSIPPPPASAPPVGPHRHFHA-----HGPVPGPQHYTLGRPGRAPRRGAGGHPQF 1353
Q S+ V P H H+ H P P P PG AP HP
Sbjct: 1645 NSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPP------PGPAPHHHPPPHPST 1698
Query: 1354 APHGRHPLHQ---PTSPLPLYSPAPQ---------------HPPAHKQGPKHFIFSHHPQ 1395
G HQ ++P P P P H P H QGP F S HP
Sbjct: 1699 GLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPH-QGPPLFPSSAHPT 1757
Query: 1396 MMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIP---PH-----PSYPPLPPPSPHT 1447
+ P A + PG P H S PH P+P PH P+ P P S
Sbjct: 1758 VPPYPSQATHHTTLGPG-----PQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFC 1812
Query: 1448 PH--SPLPPTSPHGPLHASGPPG 1468
PH S P GP AS PG
Sbjct: 1813 PHPGSVALPHGVQGPQQASPVPG 1835
Score = 63.2 bits (152), Expect = 2e-09
Identities = 67/240 (27%), Positives = 81/240 (33%), Gaps = 47/240 (19%)
Query: 1159 VGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKR---GK 1215
VG + + GS I S +PPPPPPP P + P + S+ L L +
Sbjct: 1656 VGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPH--HHPPPHPSTGLQGLQAQHQHVVNS 1713
Query: 1216 GPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGP 1275
P PPPP AS +S HH H G
Sbjct: 1714 APPPPPPPPPSSVLASGHHTTSAQALHHPPHQG--------------------------- 1746
Query: 1276 GPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYT 1335
PP + P++PP P Q LG P P GPH PV GP H
Sbjct: 1747 ---PPLFPSSAHPTVPPYPSQATHHTTLG--PGPQHQPSGTGPHCPL----PVTGP-HLQ 1796
Query: 1336 LGRPGRAPRRGAGGHPQFAPH-GRHPLHQPTSPLPLYSPAPQHPPAHK-QGPKHFIFSHH 1393
P P A G F PH G L SP P P H+ Q P F ++H
Sbjct: 1797 PQGPNSIPTPTASG---FCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYH 1853
Score = 55.1 bits (131), Expect = 5e-07
Identities = 87/345 (25%), Positives = 110/345 (31%), Gaps = 64/345 (18%)
Query: 1174 PRPHQRMPPP---PPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASA 1230
P PH PP P P Y S +P S LGS + Q P T Q
Sbjct: 1443 PSPHLENPPKSSTPHTPVQHGYLSPKPPSQQ---LGSPYRPHHS----QSPQVGTPQREP 1495
Query: 1231 SSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSL 1290
+ + + + S P GQS A ++Q+ Q +
Sbjct: 1496 QRNFYPAAQNLPANTQQATSGTLFTQTPSGQSS--ATYSQFNQ----------QSLNSTA 1543
Query: 1291 PPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGR----PGRAPRRG 1346
PPPP PPP P A+ + G + +T G PG ++
Sbjct: 1544 PPPPPPPPPSSSYYQNQQPSANF-----QNYNQLKGSLSQQTVFTSGPNQALPGTTSQQT 1598
Query: 1347 AGGHP----QFAPHGRHPLHQPTS-----PLPLYSPAP------------QHPPAHKQGP 1385
GH F P +H T+ P P PAP QH AH GP
Sbjct: 1599 VPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGP 1658
Query: 1386 KHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSH--PHHPQSPLSPHSPIPPHPSYPPLPPP 1443
H + AG P PPG + H P HP + L H PPP
Sbjct: 1659 VHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPP 1718
Query: 1444 SPHTP-------HSPLPPTSPHGPLHASGPPGTANPPSANPKAKP 1481
P P H + H P H GPP P SA+P P
Sbjct: 1719 PPPPPSSVLASGHHTTSAQALHHPPH-QGPP--LFPSSAHPTVPP 1760
Score = 48.9 bits (115), Expect = 4e-05
Identities = 69/272 (25%), Positives = 97/272 (35%), Gaps = 37/272 (13%)
Query: 1230 ASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPS 1289
++++ A S +H H S LP +KL + + + P + P+ P Q
Sbjct: 1405 SNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGY 1464
Query: 1290 LPPPPQQPPPLPQLGS-IPPPPASAPPVG-----PHRHFH--AHGPVPGPQHYTLGRPGR 1341
L P PP QLGS P + +P VG P R+F+ A Q T G
Sbjct: 1465 LSP----KPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFT 1520
Query: 1342 APRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAG 1401
G ++ + L+ T+P P P P Q P F ++ Q+ +
Sbjct: 1521 QTPSGQSS-ATYSQFNQQSLNS-TAPPPPPPPPPSSSYYQNQQPS-ANFQNYNQLKGSLS 1577
Query: 1402 A----AGGPGSRPPG--------GSYSHPHH---PQSPLSPH----SPIPPHPSYPPLPP 1442
GP PG G + P H Q+P H + +PP P PP P
Sbjct: 1578 QQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPP--PPPPA 1635
Query: 1443 PSPHTPHSPLPPTSPHGPLHASGPPGTANPPS 1474
P PH P H H GP P S
Sbjct: 1636 PGPHLVQQP-NSHQQHSVAHVVGPVHAVTPGS 1666
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 89.7 bits (221), Expect = 2e-17
Identities = 116/413 (28%), Positives = 150/413 (36%), Gaps = 55/413 (13%)
Query: 1097 KQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRR 1156
+ G RP G + S T+AR A + KR ALS+ R + G
Sbjct: 110 RASGTTRPGPLGQKGLRISAEETVARGK------ATEAPKRSALSAGARRDTSGPTPGTP 163
Query: 1157 NSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKG 1216
+ + S G+ + PRP P PP P KS S S+ S +R
Sbjct: 164 SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR--KSVSSASEHSTTEPSPAARRRPSA 221
Query: 1217 PFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSK-----LQALHAQY 1271
+ P + S+S++ SS G S G P S+ LQAL
Sbjct: 222 GGGLQRPASRSLSSSATPLSSPARS------GPSARGTPRAPAHPSQPKPKGLQALRPPQ 275
Query: 1272 CQGP--------GPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIP--PPPASAPPVGPHRH 1321
P GP L PS PP P PP L L S P PP + +G
Sbjct: 276 VTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTL 335
Query: 1322 FHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPH-GRHPLHQPTSP------LPLYSPA 1374
H +P P L P PQ P PL P SP PL +P+
Sbjct: 336 QATHSFLPSPPLSPLATP----------PPQAPPALALPPLQAPPSPPASPPLSPLATPS 385
Query: 1375 PQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHP--HHPQSPLSPHSPIP 1432
PQ P A FS P P A P + PP + P P S +P +P
Sbjct: 386 PQAPNALAVHLLQAPFS--PPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP 443
Query: 1433 PH-PSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANP--KAKPS 1482
P P+ PP+ P + P +P P +P PL + PP A P A P +A PS
Sbjct: 444 PSPPASPPMSPSATPPPQAPPPLAAP--PLQLAKPPPQAPPALATPPLQALPS 494
Score = 81.6 bits (200), Expect = 5e-15
Identities = 100/337 (29%), Positives = 122/337 (36%), Gaps = 90/337 (26%)
Query: 1172 SSPRPHQRMPPPPPPPPPEEYKS--QRPVSNSSSFLGSLFGSKRGKGPFQMPP------- 1222
S+P Q +P PP PP + S + + SFL S S P Q PP
Sbjct: 307 SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL 366
Query: 1223 --PPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPP 1280
PP+ AS S ++ P + L Q P P+PP
Sbjct: 367 QAPPSPPASPPLSPLATPS------------------PQAPNALAVHLLQAPFSPPPSPP 408
Query: 1281 -------PYLPPQQPSLPPPPQQPPPL--PQLGSIPPPPASAPPVGPHRHFHAHGPVPGP 1331
P PP PS PP Q PP L P L +PP P ++PP+ P P P
Sbjct: 409 VQAPFSPPASPPVSPSATPPSQAPPSLAAPPL-QVPPSPPASPPMSP-------SATPPP 460
Query: 1332 QHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFS 1391
Q AP PL P PL L P PQ PPA P
Sbjct: 461 Q---------AP---------------PPLAAP--PLQLAKPPPQAPPALATPPL----- 489
Query: 1392 HHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSP---IPPHPSYPPLPPPS---- 1444
Q +P+ A PG P S S P P + P +P P PP PP S
Sbjct: 490 ---QALPSP-PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 545
Query: 1445 -PHTPHSPLPPTSPHGP-LHASGPPGTANPPSANPKA 1479
P P +P P TS GP L + PG PPS +P +
Sbjct: 546 APRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 582
Score = 68.6 bits (166), Expect = 4e-11
Identities = 82/307 (26%), Positives = 107/307 (34%), Gaps = 55/307 (17%)
Query: 1176 PHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSA 1235
P +PP PP P P++ S + + PF PP P QA S ++
Sbjct: 359 PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 418
Query: 1236 SSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQ 1295
P Q+ +L A Q P PP PP PS PPPQ
Sbjct: 419 PPVSP--------------SATPPSQAP-PSLAAPPLQVP--PSPPASPPMSPSATPPPQ 461
Query: 1296 QPPPL--PQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQF 1353
PPPL P L PPP + P + A P+ PG+AP F
Sbjct: 462 APPPLAAPPLQLAKPPPQAPPAL-------ATPPLQALPSPPASFPGQAP---------F 505
Query: 1354 APHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGG 1413
+P P+ PL +P PQ PP P PA+ P P G
Sbjct: 506 SPSASLPMS------PLATPPPQAPPVLAAP-----LLQVPPSPPASPTLQAPRRPPTPG 554
Query: 1414 SYSHPHHPQSPLSPHSPIPPHPSYPPL-----PPPSPHTPHSPLPPTSPHGPLHASGPPG 1468
+ P+ L+ PP PS P P + H+ + P G + SGP G
Sbjct: 555 PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRG--YDSGPEG 612
Query: 1469 --TANPP 1473
A+PP
Sbjct: 613 GAAASPP 619
Score = 55.5 bits (132), Expect = 4e-07
Identities = 101/365 (27%), Positives = 134/365 (36%), Gaps = 71/365 (19%)
Query: 1173 SPRPHQRMPPPPPPPPPEEYK--------SQRPVSNSSSFLG--SLFGSKRGKGPFQMPP 1222
+PRP P PPPP P + ++P++ + +G ++ S GP +
Sbjct: 26 TPRPPGS-PRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSR 84
Query: 1223 PPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPY 1282
PP + A +T G + G P GQ L+ + A+ G A
Sbjct: 85 PPASGRGERAPPAKNT-SPGPVSSPGRASGTTRPGPLGQKGLR-ISAEETVARGKATE-- 140
Query: 1283 LPPQQPSLP---------PPPQQPPPLPQLGS--------IPPPPASAPPVGPHRHFHAH 1325
P++ +L P P P P S +P P SA P P
Sbjct: 141 -APKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP-----TE 194
Query: 1326 GP---VPGPQHYTLGRPGRAPRR--GAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHP-- 1378
GP V ++ P A RR AGG Q P R +S PL SPA P
Sbjct: 195 GPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ-RPASR---SLSSSATPLSSPARSGPSA 250
Query: 1379 ------PAH--KQGPKHFIFSHHPQMMPA---AGAAGGPGSRPPGGSYSHPHHPQSPLSP 1427
PAH + PK PQ+ P A A GP S P + S P P SP +P
Sbjct: 251 RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS-PSAPPSPSAP 309
Query: 1428 HS--PIPPHPSYPP------LPPPSPHTPHS--PLPPTSPHGPLHASGPPGTANPPSANP 1477
S +P P+ PP L P+ HS P PP SP PP A PP P
Sbjct: 310 PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAP 369
Query: 1478 KAKPS 1482
+ P+
Sbjct: 370 PSPPA 374
Score = 46.2 bits (108), Expect = 2e-04
Identities = 71/254 (27%), Positives = 90/254 (35%), Gaps = 41/254 (16%)
Query: 1176 PHQRMPPPPPPPPPEEYKSQRPVSN-SSSFLGSLFGSKRGKGPFQMPPPPTGQASAS--- 1231
P ++PP PP P + + P +S G GP PPPP+ S++
Sbjct: 530 PLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP---PPPPSRSPSSTLSG 586
Query: 1232 ------SSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALH-AQYCQGPGPAPPPYLP 1284
SSSA+ST + G GG P ++L A H A + +GP P P +
Sbjct: 587 PDLAGHSSSATSTPEELRGYDSG-PEGGAAASPPPDAELAACHPAAWSRGPAP-PLAFRG 644
Query: 1285 PQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV-PGPQHYTLGRPGRAP 1343
LP PP P GS GP A G + PGP T G A
Sbjct: 645 APGAPLPWPPATGP-----GSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAA- 698
Query: 1344 RRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAA 1403
GAG R P LPL A + + S + A GAA
Sbjct: 699 --GAGA----GASSRSPKQARLGELPL--------GALQASVVQHLLSRTLLLAAAEGAA 744
Query: 1404 G----GPGSRPPGG 1413
G GPG GG
Sbjct: 745 GGSGGGPGGAEGGG 758
Score = 44.7 bits (104), Expect = 7e-04
Identities = 69/244 (28%), Positives = 84/244 (34%), Gaps = 51/244 (20%)
Query: 1171 ISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASA 1230
+S PR + P PPPPP S+ P S S GP +
Sbjct: 559 VSGPRLTLALAPGPPPPP-----SRSPSSTLS-------------GP---------DLAG 591
Query: 1231 SSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALH-AQYCQGPGPAPPPYLPPQQPS 1289
SSSA+ST + G GG P ++L A H A + +GP P P +
Sbjct: 592 HSSSATSTPEELRGYDSG-PEGGAAASPPPDAELAACHPAAWSRGPAP-PLAFRGAPGAP 649
Query: 1290 LPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV-PGPQHYTLGRPGRAPRRGAG 1348
LP PP P GS GP A G + PGP T G A GAG
Sbjct: 650 LPWPPATGP-----GSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAA---GAG 701
Query: 1349 GHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGS 1408
R P LPL A + + S + A GAAGG G
Sbjct: 702 A----GASSRSPKQARLGELPL--------GALQASVVQHLLSRTLLLAAAEGAAGGSGG 749
Query: 1409 RPPG 1412
P G
Sbjct: 750 GPGG 753
Score = 43.5 bits (101), Expect = 0.002
Identities = 68/266 (25%), Positives = 84/266 (31%), Gaps = 64/266 (24%)
Query: 1277 PAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGP-------VP 1329
P P P + S PP + P + P P S+P G GP +
Sbjct: 71 PESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSP--GRASGTTRPGPLGQKGLRIS 128
Query: 1330 GPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLP----------------LYSP 1373
+ G+ AP+R A + R PT P L P
Sbjct: 129 AEETVARGKATEAPKRSA-----LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRP 183
Query: 1374 APQ-HPPAHKQGPKHFI--FSHHPQMMPAAGA-----AGGPGSRPPGGSYSHPHHPQSPL 1425
AP P +GP+ + S H P+ A AGG RP S S P S
Sbjct: 184 APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243
Query: 1426 SPHSP-------IPPHPSYP------PLPPPSPHTPH------------SPLPPTSPHGP 1460
+ P P HPS P L PP P SPL SP P
Sbjct: 244 ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAP 303
Query: 1461 LHASGPPGTANPPSANPKAKPSRIST 1486
S PP PS P PS+ +T
Sbjct: 304 PSPSAPPSLQTLPSP-PATPPSQATT 328
Score = 38.5 bits (88), Expect = 0.049
Identities = 42/142 (29%), Positives = 52/142 (36%), Gaps = 13/142 (9%)
Query: 167 GRERGGREAGPAHPGREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTS 226
G G PAHP + K G A PPR+ + G SSSP A S S
Sbjct: 247 GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPLATPSPSAPPS 305
Query: 227 TSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGP-- 284
S +LQ T+ P S +T++ SP Q + PP S P
Sbjct: 306 PSAPPSLQ---------TLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQ 356
Query: 285 -PAGVGLPWAQRARLQPASVAL 305
P + LP Q PAS L
Sbjct: 357 APPALALPPLQAPPSPPASPPL 378
Score = 35.0 bits (79), Expect = 0.54
Identities = 47/187 (25%), Positives = 55/187 (29%), Gaps = 32/187 (17%)
Query: 483 PSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGR 542
PS P S L+ S S AT+ P SP P PPPQ
Sbjct: 300 PSAPPSPS-APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP 358
Query: 543 PEFWAPA----PLPPVPPPV-PSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIE 597
P P P PP PP+ P T + P L A HL
Sbjct: 359 PALALPPLQAPPSPPASPPLSPLATPSP--------QAPNAL--------AVHLLQAPFS 402
Query: 598 PPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPA 657
PP V + SP T + PP A P + P+P P
Sbjct: 403 PPPSPPVQAPFSPPA----------SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 452
Query: 658 PPGPLPP 664
P PP
Sbjct: 453 SPSATPP 459
Score = 34.7 bits (78), Expect = 0.71
Identities = 48/162 (29%), Positives = 55/162 (33%), Gaps = 24/162 (14%)
Query: 525 PQQSPERLPSTEPPPQGRPEFWAP----APLPPVPPPVPSGTREDGSREEGTRRGPGCLE 580
P S P PPPQ P AP P PP P + + R + + GP
Sbjct: 507 PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGP---- 562
Query: 581 CRDFRLRAAHLPLLTIEPPSDSSVDLS--DRSDRGSVHRQLVYEADG--CSPHGTLKHKG 636
RL A P P S LS D + S E G P G
Sbjct: 563 ----RLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAA-AS 617
Query: 637 PPGRAPIPHRHYPA-PEGPAP------APPGPLPPAPNSGTG 671
PP A + H A GPAP AP PLP P +G G
Sbjct: 618 PPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG 659
Score = 32.7 bits (73), Expect = 2.7
Identities = 28/92 (30%), Positives = 32/92 (34%), Gaps = 4/92 (4%)
Query: 470 SLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSP 529
+LA + +A P P + P S S S A P P SP
Sbjct: 391 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 450
Query: 530 ERLPSTEPPPQGRPEFWAP----APLPPVPPP 557
PS PPPQ P AP A PP PP
Sbjct: 451 PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPP 482
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 1124
Score = 89.4 bits (220), Expect = 2e-17
Identities = 96/315 (30%), Positives = 118/315 (37%), Gaps = 63/315 (20%)
Query: 1176 PHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSA 1235
P + PP PP PP P++ S + + PF PP P QA S ++
Sbjct: 628 PPLQAPPSPPASPP-----LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 682
Query: 1236 SSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQ 1295
P Q+ +L A Q P PP PP PS PPPQ
Sbjct: 683 PPV--------------SPSATPPSQAP-PSLAAPPLQ--VPPSPPASPPMSPSATPPPQ 725
Query: 1296 QPPPL--PQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQF 1353
PPPL P L +PP P ++PP+ P + P R P A Q
Sbjct: 726 APPPLAAPPL-QVPPSPPASPPMSP----------------SATPPPRVPPLLAAPPLQV 768
Query: 1354 APHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGG 1413
P P P SPL P PQ PPA P Q +P+ A PG P
Sbjct: 769 PP--SPPASLPMSPLA--KPPPQAPPALATPPL--------QALPSP-PASFPGQAPFSP 815
Query: 1414 SYSHPHHPQSPLSPHSP---IPPHPSYPPLPPPS-----PHTPHSPLPPTSPHGP-LHAS 1464
S S P P + P +P P PP PP S P P +P P TS GP L +
Sbjct: 816 SASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLA 875
Query: 1465 GPPGTANPPSANPKA 1479
PG PPS +P +
Sbjct: 876 LAPGPPPPPSRSPSS 890
Score = 70.9 bits (172), Expect = 9e-12
Identities = 76/246 (30%), Positives = 92/246 (37%), Gaps = 49/246 (19%)
Query: 1264 LQALHAQYCQGP-GPAPPPYLPPQQ-------PSLPPPPQQ--PPPLPQLGSIPPPP--- 1310
LQAL + P P +PP + PSL PP PPL L S+ PPP
Sbjct: 489 LQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQT 548
Query: 1311 ASAPPVGPHRHFH---AHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQ--PT 1365
ASAP PH A P+ P P P A PQ P P Q P+
Sbjct: 549 ASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPS 608
Query: 1366 SPL-PLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSP 1424
PL PL +P PQ PP +P A P + PP + P PQ+P
Sbjct: 609 PPLSPLATPPPQAPPX--------------LALPPLQAPPSPPASPPLSPLATPS-PQAP 653
Query: 1425 --------LSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSAN 1476
+P SP P P P PP+ PP SP + PP A PP
Sbjct: 654 NALAVHLLQAPFSPPPSPPVQAPFSPPAS-------PPVSPSATPPSQAPPSLAAPPLQV 706
Query: 1477 PKAKPS 1482
P + P+
Sbjct: 707 PPSPPA 712
Score = 67.8 bits (164), Expect = 8e-11
Identities = 68/215 (31%), Positives = 77/215 (35%), Gaps = 31/215 (14%)
Query: 1275 PGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHY 1334
P PAP P P P PPP+ P SI PP APP + P
Sbjct: 562 PCPAPCPLQAPPSPLTTPPPETP------SSIATPPPQAPPA-----------LASPPLQ 604
Query: 1335 TLGRPGRAPRRGAGGHPQFAPH-GRHPLHQPTSP------LPLYSPAPQHPPAHKQGPKH 1387
L P +P A PQ P PL P SP PL +P+PQ P A
Sbjct: 605 GLPSPPLSPL--ATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 662
Query: 1388 FIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPH- 1446
FS P P A P + PP + P P P+ PS P PP SP
Sbjct: 663 APFSPPPS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA 720
Query: 1447 TPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKP 1481
TP PP PL PP P +P A P
Sbjct: 721 TPPPQAPPPLAAPPLQV--PPSPPASPPMSPSATP 753
Score = 66.6 bits (161), Expect = 2e-10
Identities = 74/238 (31%), Positives = 86/238 (36%), Gaps = 46/238 (19%)
Query: 1275 PGPAPPPYL----------PPQQPSLPPPPQQPPPL--PQLGSIPPPPASAPPVGP---- 1318
P P PP L PP P PPPQ PP L P L + P PPAS PP+ P
Sbjct: 590 PPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPAS-PPLSPLATP 648
Query: 1319 ----------HRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPL 1368
H P P P P +AP P +P P P S
Sbjct: 649 SPQAPNALAVHLLQAPFSPPPSP-------PVQAPFSPPAS-PPVSPSATPPSQAPPS-- 698
Query: 1369 PLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPH 1428
L +P Q PP+ P + P P AA P PP S P P + P
Sbjct: 699 -LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQVPPSPPASPPMSPSATPPPR 756
Query: 1429 SP---IPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTA--NPPSANPKAKP 1481
P P PP PP S P SPL P P + PP A +PP++ P P
Sbjct: 757 VPPLLAAPPLQVPPSPPAS--LPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAP 812
Score = 63.9 bits (154), Expect = 1e-09
Identities = 118/492 (23%), Positives = 148/492 (30%), Gaps = 120/492 (24%)
Query: 1097 KQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRR 1156
+ G RP G + S T+AR A + KR ALS+ R + G
Sbjct: 119 RASGTTRPGPLGQKGLRISAEETVARGK------ATEAPKRSALSAGARRDTSGPTPGTP 172
Query: 1157 NSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKR--G 1214
+ + S G+ + PRP P PP P KS S S+ S +R
Sbjct: 173 SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR--KSVSSASEHSTTEPSPAARRRPSA 230
Query: 1215 KGPFQMP--------PPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLP-------- 1258
G Q P P + S SA T H G + P
Sbjct: 231 GGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK 290
Query: 1259 DGQSKLQALHAQYCQGPGPA-------PPP---------YLPPQQ------PSLPPPPQQ 1296
D L L + P P+ PPP LPP P PP P
Sbjct: 291 DAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSA 350
Query: 1297 PPPLPQLGSIP-------PPPASAPPVGPHRHFHAHGPVPGPQHYT-------------- 1335
PP L L S P PP + PP+ P+ P T
Sbjct: 351 PPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALS 410
Query: 1336 -------LGRPG-------------------RAPRRGAGGHPQFAPHGRHPLHQPTSP-- 1367
LG P +P R A P +P + PL P SP
Sbjct: 411 SLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPD-SPPLQAPLSLPASPPL 469
Query: 1368 ----LPLYSPAPQHPPAHKQGPKHFIFSHHPQ------MMP---AAGAAGGPGSRPPGGS 1414
P SP H + SH PQ +MP + P + P S
Sbjct: 470 QTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPAS 529
Query: 1415 YSHPHHPQSPLSPHSPI--------PPHPSYPPLPPPSP-HTPHSPLPPTSPHGPLHASG 1465
+ P P P+ PH PP P P P P SPL P P +
Sbjct: 530 LTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIAT 589
Query: 1466 PPGTANPPSANP 1477
PP A P A+P
Sbjct: 590 PPPQAPPALASP 601
Score = 56.2 bits (134), Expect = 2e-07
Identities = 88/316 (27%), Positives = 106/316 (33%), Gaps = 65/316 (20%)
Query: 1176 PHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSA 1235
P ++PP PP PP + P P Q+PP P S S+
Sbjct: 702 PPLQVPPSPPASPPMSPSATPPPQAPPPLAAP---------PLQVPPSPPASPPMSPSAT 752
Query: 1236 SSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQ 1295
V P L A Q P P+PP L P P PPPQ
Sbjct: 753 PPPR----------------VPP-------LLAAPPLQVP-PSPPASL-PMSPLAKPPPQ 787
Query: 1296 QPPPL--PQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQF 1353
PP L P L ++P PPAS P P F +P T P +AP A
Sbjct: 788 APPALATPPLQALPSPPASFPGQAP---FSPSASLPMSPLAT--PPPQAPPVLA------ 836
Query: 1354 APHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGG 1413
AP + P P SP AP+ PP GP + + A G P SR P
Sbjct: 837 APLLQVPPSPPASPT---LQAPRRPPT--PGPDTSVSGPRLTLALAPGPP-PPPSRSPSS 890
Query: 1414 SYSHPH---HPQSPLSPHSPIPPHPSYP-----PLPPPSPHTP--HSPLPPTSPHGPLHA 1463
+ S P H S S + + S P PPP H P PL
Sbjct: 891 TLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAF 950
Query: 1464 SGPPGTAN--PPSANP 1477
G PG PP+ P
Sbjct: 951 RGAPGAPLPWPPATGP 966
Score = 55.5 bits (132), Expect = 4e-07
Identities = 83/314 (26%), Positives = 101/314 (32%), Gaps = 70/314 (22%)
Query: 1176 PHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSA 1235
P ++PP PP PP S P L + P Q+PP P S +
Sbjct: 733 PPLQVPPSPPASPPMS-PSATPPPRVPPLLAA--------PPLQVPPSPPASLPMSPLAK 783
Query: 1236 SSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAP--PPYLPPQQPSLPPP 1293
+ L P LQAL + PG AP P P P PP
Sbjct: 784 PPPQ----------APPALATPP-----LQALPSPPASFPGQAPFSPSASLPMSPLATPP 828
Query: 1294 PQQPPPL--PQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLG-------------R 1338
PQ PP L P L P PPAS P R P PGP G
Sbjct: 829 PQAPPVLAAPLLQVPPSPPASPTLQAPRR-----PPTPGPDTSVSGPRLTLALAPGPPPP 883
Query: 1339 PGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMP 1398
P R+P G P A H P L Y P+ A P + + HP
Sbjct: 884 PSRSPSSTLSG-PDLAGHSSSATSTP-EELRGYDSGPEGGAAASPPPDAELAACHP---- 937
Query: 1399 AAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPH 1458
AA G PP +P +P+P +PP P + T
Sbjct: 938 ---AAWSRGPAPPLAFRG---------APGAPLP----WPPATGPGSADGLCTIYET--E 979
Query: 1459 GPLHASGPPGTANP 1472
GP A+ PG +P
Sbjct: 980 GPESATPAPGALDP 993
Score = 53.9 bits (128), Expect = 1e-06
Identities = 102/384 (26%), Positives = 128/384 (33%), Gaps = 93/384 (24%)
Query: 1142 SSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPH----------QRMPPPPPPP---- 1187
++LR L AG GR+ + I G+ I P R P PP
Sbjct: 42 AALRVLGAAGAVGRK-PLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRG 100
Query: 1188 ---PPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHH 1244
PP + S PVS+ G G+ R P P GQ S+ +
Sbjct: 101 ERAPPAKNTSPGPVSSP----GRASGTTR--------PGPLGQKGLRISAEETVAR---- 144
Query: 1245 HHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPP-PYLPPQQPSLPPPPQQPPPLPQL 1303
G +S L A + GP P P P + + + P P P
Sbjct: 145 --------GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS- 195
Query: 1304 GSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRR--GAGGHPQFAPHGRHPL 1361
+ P PP P V ++ P A RR AGG Q P R
Sbjct: 196 -ARPRPPTEGP----------RKSVSSASEHSTTEPSPAARRRPSAGGGLQ-RPASRS-- 241
Query: 1362 HQPTSPLPLYSPAPQHP--------PAH--KQGPKHFIFSHHPQMMP----AAGAAGGPG 1407
+S PL SPA P PAH + PK PQ+ P AA A G
Sbjct: 242 -LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300
Query: 1408 SRP-----PGGSYSHPHHPQSPLSPHSPIPPHPSYP-----PLPPPSPHTPHS----PLP 1453
S P P G+ + P P + P PS P PL PPSP P S P P
Sbjct: 301 SSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSP 360
Query: 1454 PTSPHGPLHASGPPGTANPPSANP 1477
P +P + PP PP P
Sbjct: 361 PATP----PSQAPPSMTTPPMQAP 380
Score = 46.2 bits (108), Expect = 2e-04
Identities = 71/254 (27%), Positives = 90/254 (35%), Gaps = 41/254 (16%)
Query: 1176 PHQRMPPPPPPPPPEEYKSQRPVSN-SSSFLGSLFGSKRGKGPFQMPPPPTGQASAS--- 1231
P ++PP PP P + + P +S G GP PPPP+ S++
Sbjct: 838 PLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP---PPPPSRSPSSTLSG 894
Query: 1232 ------SSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALH-AQYCQGPGPAPPPYLP 1284
SSSA+ST + G GG P ++L A H A + +GP P P +
Sbjct: 895 PDLAGHSSSATSTPEELRGYDSG-PEGGAAASPPPDAELAACHPAAWSRGPAP-PLAFRG 952
Query: 1285 PQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV-PGPQHYTLGRPGRAP 1343
LP PP P GS GP A G + PGP T G A
Sbjct: 953 APGAPLPWPPATGP-----GSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAA- 1006
Query: 1344 RRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAA 1403
GAG R P LPL A + + S + A GAA
Sbjct: 1007 --GAGA----GASSRSPKQARLGELPL--------GALQASVVQHLLSRTLLLAAAEGAA 1052
Query: 1404 G----GPGSRPPGG 1413
G GPG GG
Sbjct: 1053 GGSGGGPGGAEGGG 1066
Score = 44.7 bits (104), Expect = 7e-04
Identities = 69/244 (28%), Positives = 84/244 (34%), Gaps = 51/244 (20%)
Query: 1171 ISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASA 1230
+S PR + P PPPPP S+ P S S GP +
Sbjct: 867 VSGPRLTLALAPGPPPPP-----SRSPSSTLS-------------GP---------DLAG 899
Query: 1231 SSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALH-AQYCQGPGPAPPPYLPPQQPS 1289
SSSA+ST + G GG P ++L A H A + +GP P P +
Sbjct: 900 HSSSATSTPEELRGYDSG-PEGGAAASPPPDAELAACHPAAWSRGPAP-PLAFRGAPGAP 957
Query: 1290 LPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV-PGPQHYTLGRPGRAPRRGAG 1348
LP PP P GS GP A G + PGP T G A GAG
Sbjct: 958 LPWPPATGP-----GSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAA---GAG 1009
Query: 1349 GHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGS 1408
R P LPL A + + S + A GAAGG G
Sbjct: 1010 A----GASSRSPKQARLGELPL--------GALQASVVQHLLSRTLLLAAAEGAAGGSGG 1057
Query: 1409 RPPG 1412
P G
Sbjct: 1058 GPGG 1061
Score = 38.1 bits (87), Expect = 0.064
Identities = 70/270 (25%), Positives = 92/270 (34%), Gaps = 29/270 (10%)
Query: 470 SLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSP 529
+LA + +A P P + P S S S A P P SP
Sbjct: 655 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 714
Query: 530 ERLPSTEPPPQGRPEFWAP----APLPPVPPPV-PSGTREDGSREEGTRRGPGCLECRDF 584
PS PPPQ P AP P PP PP+ PS T R P L
Sbjct: 715 PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPP--------RVPPLLAAPPL 766
Query: 585 RL---RAAHLPLLTI-EPPSDSSVDLSD------RSDRGSVHRQLVYEADGCSPHGTLKH 634
++ A LP+ + +PP + L+ S S Q + P L
Sbjct: 767 QVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL-- 824
Query: 635 KGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPN--SGTGPSGVAGGRRLGKCEAAGENSD 692
PP +AP P P + P P P AP GP G RL A G
Sbjct: 825 ATPPPQAP-PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 883
Query: 693 GGDNESLESSSNSNETINCSSGSSSRDSLR 722
+ S + S + + SS +S+ + LR
Sbjct: 884 PSRSPS-STLSGPDLAGHSSSATSTPEELR 912
Score = 35.4 bits (80), Expect = 0.41
Identities = 27/80 (33%), Positives = 37/80 (46%), Gaps = 8/80 (10%)
Query: 649 PAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNET 708
P P G +P PP P+ PA G +G G + L E AG ES + +
Sbjct: 27 PRPPG-SPRPPPPVTPAALRVLGAAGAVGRKPL--AERAGGIGGATIPESAPRAGPTR-- 81
Query: 709 INCSSGSSSRDSLREPPATG 728
S+G+SSR+ PPA+G
Sbjct: 82 ---SAGTSSRNPASRPPASG 98
Score = 35.0 bits (79), Expect = 0.54
Identities = 56/204 (27%), Positives = 67/204 (32%), Gaps = 28/204 (13%)
Query: 483 PSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGR 542
P P+++ P A Q S SF + P S P PPPQ
Sbjct: 777 PMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS----PSASLPMSPLATPPPQAP 832
Query: 543 PEFWAP----APLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEP 598
P AP P PP P + + R + + GP RL A P P
Sbjct: 833 PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGP--------RLTLALAPGPPPPP 884
Query: 599 PSDSSVDLS--DRSDRGSVHRQLVYEADG--CSPHGTLKHKGPPGRAPIPHRHYPA-PEG 653
S LS D + S E G P G PP A + H A G
Sbjct: 885 SRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAA-ASPPPDAELAACHPAAWSRG 943
Query: 654 PAP------APPGPLPPAPNSGTG 671
PAP AP PLP P +G G
Sbjct: 944 PAPPLAFRGAPGAPLPWPPATGPG 967
Score = 34.7 bits (78), Expect = 0.71
Identities = 37/142 (26%), Positives = 43/142 (30%), Gaps = 31/142 (21%)
Query: 528 SPERLPSTEPPPQGRPEFWAPA----PLPPVPPPV-PSGTREDGSREEGTRRGPGCLECR 582
SP P PPPQ P P P PP PP+ P T + P L
Sbjct: 608 SPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSP--------QAPNAL--- 656
Query: 583 DFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAP 642
A HL PP V + SP T + PP A
Sbjct: 657 -----AVHLLQAPFSPPPSPPVQAPFSPPA----------SPPVSPSATPPSQAPPSLAA 701
Query: 643 IPHRHYPAPEGPAPAPPGPLPP 664
P + P+P P P PP
Sbjct: 702 PPLQVPPSPPASPPMSPSATPP 723
Score = 32.7 bits (73), Expect = 2.7
Identities = 36/138 (26%), Positives = 49/138 (35%), Gaps = 14/138 (10%)
Query: 167 GRERGGREAGPAHPGREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTS 226
G G PAHP + K G A PPR+ + G SSSP A +
Sbjct: 256 GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG-PLSSSPLA--------T 306
Query: 227 TSPATTLQRKSDGENSRTVSVEGDAPGS-----DLSTAVDSPGSQPPYRLSQLPPSSSHM 281
SP+ T R ++ + P S L A SP + P + PP++
Sbjct: 307 PSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPS 366
Query: 282 GGPPAGVGLPWAQRARLQ 299
PP+ P LQ
Sbjct: 367 QAPPSMTTPPMQAPPSLQ 384
Score = 31.6 bits (70), Expect = 6.0
Identities = 58/215 (26%), Positives = 77/215 (35%), Gaps = 30/215 (13%)
Query: 523 TVPQQSPE-----------RLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEG 571
T+P+ +P R P++ PP GR E AP P PV S R G+
Sbjct: 69 TIPESAPRAGPTRSAGTSSRNPASRPPASGRGE-RAPPAKNTSPGPVSSPGRASGT---- 123
Query: 572 TRRGPGCLECRDFRLRAAHLPL--LTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPH 629
TR GP L + R+ A E P S++ R D A
Sbjct: 124 TRPGP--LGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181
Query: 630 GTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGE 689
G P AP R P EGP + + +S T PS A R +AG
Sbjct: 182 AAGTEVGLPRPAP-SARPRPPTEGPRKSVSS---ASEHSTTEPSPAARRR-----PSAGG 232
Query: 690 NSDGGDNESLESSSNSNETINCSSGSSSRDSLREP 724
+ SL SS+ + SG S+R + R P
Sbjct: 233 GLQRPASRSLSSSATPLSS-PARSGPSARGTPRAP 266
>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
Length = 416
Score = 89.4 bits (220), Expect = 2e-17
Identities = 104/362 (28%), Positives = 126/362 (34%), Gaps = 83/362 (22%)
Query: 1140 LSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVS 1199
LS +L LS A S S I G+ +P P PP PP K Q P
Sbjct: 6 LSVALLALSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPG---KPQGP-- 60
Query: 1200 NSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPD 1259
+G Q PPPP G+ + G P
Sbjct: 61 -----------PPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ--------------GPPPP 95
Query: 1260 GQSKLQALHAQYCQGPGP----APPPYLPPQQPSLPPP-----PQQPPPLPQLGSIPPPP 1310
G+ QGP P + P PP +P PPP PQ PPP P PPP
Sbjct: 96 GKP----------QGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ 145
Query: 1311 ASAPPVGPHRHFHAHGPVPGPQHYTL------GRPGRAPRRGAGGHPQFAPHGRHPLHQP 1364
P GP GP P + + G+P P +G G PQ P P +P
Sbjct: 146 GGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQG-GNQPQGPP---PPPGKP 201
Query: 1365 TSPLPLYSPAPQ--HPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQ 1422
P P PQ PP QGP PQ + +A P +P G + PQ
Sbjct: 202 QGPPPQGGNKPQGPPPPGKPQGPP-------PQGDNKSQSARSPPGKPQGPPPQGGNQPQ 254
Query: 1423 SPLSPHSPIPPHPSYPPLPPP-SPHTPHSPLPPTSPHGPLHASGPP--GTANPPSANPKA 1479
P PP P P PPP + P P PP P GP PP G+ + S +P
Sbjct: 255 GP-------PPPPGKPQGPPPQGGNKPQGPPPPGKPQGP-----PPQGGSKSRSSRSPPG 302
Query: 1480 KP 1481
KP
Sbjct: 303 KP 304
Score = 89.0 bits (219), Expect = 3e-17
Identities = 102/338 (30%), Positives = 120/338 (35%), Gaps = 62/338 (18%)
Query: 1178 QRMPPPPPP--PPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSA 1235
Q PPP P PPP+ KS+ P S G +G Q PPPP G+
Sbjct: 90 QGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGP---PPQGGNQPQGPPPPPGKPQGPPPQG 146
Query: 1236 SSTHHHHHHHHHGHSHGGL--GVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPP 1293
+ G G G P G +K ++ + + GP P PQ P PPP
Sbjct: 147 GNKPQ-------GPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGP--PPP 197
Query: 1294 PQQPP-PLPQLGSIP---PPPASA---PPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRG 1346
P +P P PQ G+ P PPP PP G ++ A P G+P P +G
Sbjct: 198 PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPP--------GKPQGPPPQG 249
Query: 1347 AGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPP--AHKQGPKHFIFSHHPQMMPAAGAAG 1404
G PQ P P +P P P PQ PP QGP S G
Sbjct: 250 -GNQPQGPPP---PPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQ 305
Query: 1405 GPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSP------------L 1452
GP PP G P P P P PP P PP P P P
Sbjct: 306 GP---PPQGGNQPQGPPPPPGKPQGP-PPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARS 361
Query: 1453 PPTSPHGPLHASG-------PPGTANP--PSANPKAKP 1481
PP P GP G PP NP P A P +P
Sbjct: 362 PPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQP 399
Score = 81.6 bits (200), Expect = 5e-15
Identities = 70/220 (31%), Positives = 80/220 (36%), Gaps = 32/220 (14%)
Query: 1274 GPGPAPPPYLPPQQPSLPPP-----PQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV 1328
G P PP PP +P PPP PQ PPP P PPP P GP GP
Sbjct: 44 GNKPQGPPS-PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP 102
Query: 1329 PGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHF 1388
P G R+PR G P G +QP P P PP QGP
Sbjct: 103 P------QGDKSRSPRSPPGKPQGPPPQGG---NQPQGPPP--------PPGKPQGPPP- 144
Query: 1389 IFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTP 1448
+ PQ P G GP PP G P P P P + P PPP P P
Sbjct: 145 QGGNKPQGPPPPGKPQGP---PPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKP 201
Query: 1449 HSPLP-----PTSPHGPLHASGPPGTANPPSANPKAKPSR 1483
P P P P P GPP + S + ++ P +
Sbjct: 202 QGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGK 241
Score = 80.1 bits (196), Expect = 1e-14
Identities = 99/346 (28%), Positives = 114/346 (32%), Gaps = 66/346 (19%)
Query: 1167 EGSVISSPRPHQRMPPPPPP--------PPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPF 1218
+G SPR P PPP PPP K Q P + +G P
Sbjct: 104 QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGN-------KPQGPPPP 156
Query: 1219 QMP--PPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPG 1276
P PPP G + SS + G+ G P QGP
Sbjct: 157 GKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP 216
Query: 1277 P-----APPPY---------LPPQQPSLPPP-----PQQPPPLPQLGSIPPPPASAPPVG 1317
P PPP PP +P PPP PQ PPP P PPP P G
Sbjct: 217 PPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQG 276
Query: 1318 PHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQH 1377
P GP P Q + R R+P G P P G + QP P P
Sbjct: 277 PPPPGKPQGPPP--QGGSKSRSSRSPPGKPQGPP---PQGGN---QPQGPPP-------- 320
Query: 1378 PPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHH--PQSPLSPHSPIPPHP 1435
PP QGP + PQ P G GP P GGS S P P P +P
Sbjct: 321 PPGKPQGPPPQ-GGNKPQGPPPPGKPQGPP--PQGGSKSRSARSPPGKPQGPPQQEGNNP 377
Query: 1436 SYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKP 1481
PP PP+ P P P A P G PP ++P
Sbjct: 378 QGPP--PPAGGNPQQPQAPP-------AGQPQGPPRPPQGGRPSRP 414
Score = 48.5 bits (114), Expect = 5e-05
Identities = 44/149 (29%), Positives = 54/149 (36%), Gaps = 42/149 (28%)
Query: 537 PPPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLL 594
PPPQG +P+ P P P PP G + G G +GP
Sbjct: 245 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP------------------ 286
Query: 595 TIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGP 654
PP S S RS G + G P G + +GPP P P + P+GP
Sbjct: 287 ---PPQGGSKSRSSRSPPG--------KPQGPPPQGGNQPQGPP---PPPGK----PQGP 328
Query: 655 APA----PPGPLPPAPNSGTGPSGVAGGR 679
P P GP PP G P G + R
Sbjct: 329 PPQGGNKPQGPPPPGKPQGPPPQGGSKSR 357
Score = 47.4 bits (111), Expect = 1e-04
Identities = 28/81 (34%), Positives = 31/81 (38%), Gaps = 4/81 (4%)
Query: 1403 AGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLH 1462
AG P PP G P P P P P + P PPP P P P PP + P
Sbjct: 33 AGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP-PPQGGNKP-- 89
Query: 1463 ASGPPGTANPPSANPKAKPSR 1483
GPP P P+ SR
Sbjct: 90 -QGPPPPGKPQGPPPQGDKSR 109
Score = 47.4 bits (111), Expect = 1e-04
Identities = 46/162 (28%), Positives = 57/162 (35%), Gaps = 48/162 (29%)
Query: 525 PQQSPERLPSTEP------PPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGP 576
PQ R P + P PPQG +P+ P P P PP G + G G +GP
Sbjct: 103 PQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP 162
Query: 577 GCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKG 636
PP + S RS G + G P G + +G
Sbjct: 163 ---------------------PPQGDNKSRSSRSPPG--------KPQGPPPQGGNQPQG 193
Query: 637 PPGRAPIPHRHYPAPEGPAP----APPGPLPPAPNSGTGPSG 674
PP P P + P+GP P P GP PP G P G
Sbjct: 194 PP---PPPGK----PQGPPPQGGNKPQGPPPPGKPQGPPPQG 228
Score = 46.6 bits (109), Expect = 2e-04
Identities = 43/149 (28%), Positives = 54/149 (36%), Gaps = 42/149 (28%)
Query: 537 PPPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLL 594
PPPQG +P+ P P P PP G + G G +GP
Sbjct: 183 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP------------------ 224
Query: 595 TIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGP 654
PP + S RS G + G P G + +GPP P P + P+GP
Sbjct: 225 ---PPQGDNKSQSARSPPG--------KPQGPPPQGGNQPQGPP---PPPGK----PQGP 266
Query: 655 APA----PPGPLPPAPNSGTGPSGVAGGR 679
P P GP PP G P G + R
Sbjct: 267 PPQGGNKPQGPPPPGKPQGPPPQGGSKSR 295
Score = 43.1 bits (100), Expect = 0.002
Identities = 41/144 (28%), Positives = 50/144 (34%), Gaps = 43/144 (29%)
Query: 537 PPPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLL 594
PPPQG +P+ P P P PP G + G G +G
Sbjct: 60 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG------------------- 100
Query: 595 TIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGP 654
PP S RS G + G P G + +GPP P P + P+GP
Sbjct: 101 ---PPPQGDKSRSPRSPPG--------KPQGPPPQGGNQPQGPP---PPPGK----PQGP 142
Query: 655 AP----APPGPLPPAPNSGTGPSG 674
P P GP PP G P G
Sbjct: 143 PPQGGNKPQGPPPPGKPQGPPPQG 166
Score = 40.0 bits (92), Expect = 0.017
Identities = 39/150 (26%), Positives = 53/150 (35%), Gaps = 11/150 (7%)
Query: 533 PSTEPPPQGRPEFWAPA----PLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRA 588
P PPP G+P+ P P P PP P G G + R PG + + +
Sbjct: 68 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPG--KPQGPPPQG 125
Query: 589 AHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLK---HKGPPGRAP-IP 644
+ P PP ++ + G P G K + PPG+ P
Sbjct: 126 GNQPQGPPPPPGKPQGPPPQGGNKPQ-GPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPP 184
Query: 645 HRHYPAPEGPAPAPPGPLPPAPNSGTGPSG 674
+ P+GP P P P P P G P G
Sbjct: 185 PQGGNQPQGPPPPPGKPQGPPPQGGNKPQG 214
Score = 38.1 bits (87), Expect = 0.064
Identities = 51/201 (25%), Positives = 71/201 (35%), Gaps = 21/201 (10%)
Query: 483 PSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGR 542
P GP PG K + Q D+ + S P PQ + P PPP G+
Sbjct: 150 PQGP--PPPG-----KPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQ--PQGPPPPPGK 200
Query: 543 PEFWAPA----PLPPVPPPVPSGTREDG-SREEGTRRGPGCLECRDFRLRAAHLPLLTIE 597
P+ P P P PP P G G ++ + R PG + + + + P
Sbjct: 201 PQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPG--KPQGPPPQGGNQPQGPPP 258
Query: 598 PPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLK---HKGPPGRAP-IPHRHYPAPEG 653
PP ++ + G P G K + PPG+ P + P+G
Sbjct: 259 PPGKPQGPPPQGGNKPQ-GPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQG 317
Query: 654 PAPAPPGPLPPAPNSGTGPSG 674
P P P P P P G P G
Sbjct: 318 PPPPPGKPQGPPPQGGNKPQG 338
Score = 38.1 bits (87), Expect = 0.064
Identities = 39/134 (29%), Positives = 48/134 (35%), Gaps = 30/134 (22%)
Query: 537 PPPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLL 594
PPPQG +P+ P P P PP G + G G +GP
Sbjct: 307 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP------------------ 348
Query: 595 TIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPA--PE 652
PP S S RS G Q + +G +P G P G P + PA P+
Sbjct: 349 ---PPQGGSKSRSARSPPGK--PQGPPQQEGNNPQGP---PPPAGGNPQQPQAPPAGQPQ 400
Query: 653 GPAPAPPGPLPPAP 666
GP P G P P
Sbjct: 401 GPPRPPQGGRPSRP 414
Score = 36.6 bits (83), Expect = 0.19
Identities = 20/54 (37%), Positives = 22/54 (40%), Gaps = 4/54 (7%)
Query: 625 GCSPHGTLKHKGPPGRAPIPHRHYPA----PEGPAPAPPGPLPPAPNSGTGPSG 674
G P G K +GPP P P P+GP P P P P P G P G
Sbjct: 38 GAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQG 91
Score = 32.0 bits (71), Expect = 4.6
Identities = 35/134 (26%), Positives = 42/134 (31%), Gaps = 29/134 (21%)
Query: 1174 PRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPP-----PTGQA 1228
P P P PPPPP + + P G + +GP PPP P Q
Sbjct: 307 PPPQGGNQPQGPPPPPGKPQGPPPQ-----------GGNKPQGP---PPPGKPQGPPPQG 352
Query: 1229 SASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQP 1288
+ S SA S + G P Q P PP PQ P
Sbjct: 353 GSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQ----------PQAPPAGQPQGP 402
Query: 1289 SLPPPPQQPPPLPQ 1302
PP +P PQ
Sbjct: 403 PRPPQGGRPSRPPQ 416
>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
Length = 771
Score = 88.2 bits (217), Expect = 5e-17
Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 21/203 (10%)
Query: 781 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF 840
+S+ +A + +G R + LG + +F+R V + DFS + LD ALR F
Sbjct: 310 VSEAAHRLARRLYHLEGFQRCDVARQLG-KNNEFSRLVAGEYLSFFDFSGLTLDGALRTF 368
Query: 841 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV 900
+ GE Q+ ER++ FS+RYC CNP + D I L A++LLNTD++ ++
Sbjct: 369 LKAFPLMGETQERERVLTHFSRRYCQCNP---DDSTSEDGIHTLTCALMLLNTDLHGHNI 425
Query: 901 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELR---------------TND 945
+KM FI NL +++G+D +DLL +Y I+ +L +D
Sbjct: 426 --GKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDD 483
Query: 946 DHVSQVQAVERMIVGKKPVLSLP 968
+ + V R++ G P L +P
Sbjct: 484 KFGTGTKKVTRILDGGNPFLDVP 506
>gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]
Length = 424
Score = 87.8 bits (216), Expect = 7e-17
Identities = 83/252 (32%), Positives = 95/252 (37%), Gaps = 53/252 (21%)
Query: 1247 HGHSHGGLGVLPDGQSKLQALHAQYCQGPGP--APPPY-------LPPQQPSLPPPPQQP 1297
HG + L + S+ H + P P AP P LPP P +PPP P
Sbjct: 187 HGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPP--PGMPPPGSFP 244
Query: 1298 PPLPQLGSIPP--PPASAPPVGPHRHFHAHGP----VPGPQHYTLGR-------PGRAPR 1344
PP+P G++PP PPA PP P HGP PG H G PG P
Sbjct: 245 PPVPPPGALPPGIPPAMPPPPMPPGAA-GHGPPSAGTPGAGHPGHGHSHPHPFPPGGMPH 303
Query: 1345 RGAG------------GHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSH 1392
G GHP P G P P + P P +GP
Sbjct: 304 PGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMG 363
Query: 1393 HPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYP--PLPPPSPHTPHS 1450
HP MP G G P PP G Y+ P P PP Y PLPPP P TP
Sbjct: 364 HPGPMPPHGMRGPPPLMPPHG-YTGP-----------PRPPPYGYQRGPLPPPRP-TPRP 410
Query: 1451 PLPPTSP-HGPL 1461
P+PP P GPL
Sbjct: 411 PVPPRGPLRGPL 422
Score = 84.0 bits (206), Expect = 1e-15
Identities = 70/224 (31%), Positives = 84/224 (37%), Gaps = 39/224 (17%)
Query: 1169 SVISSPRPHQRMPPP---PPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPT 1225
S + S P MPPP PPP PP G+ P MPPPP
Sbjct: 226 SSLGSGLPPPGMPPPGSFPPPVPPP-------------------GALPPGIPPAMPPPPM 266
Query: 1226 GQASAS----SSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPP 1281
+A S+ H H H H H G+ G S++Q H GP P
Sbjct: 267 PPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAH----HGPHGLGHP 322
Query: 1282 YLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGR 1341
+ P PPP+ PP +P G PPP PP GP P P P H G P
Sbjct: 323 HAGPPGSGGQPPPRPPPGMPHPG---PPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPL 379
Query: 1342 APRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGP 1385
P G G P+ P+G PLP P P+ PP +GP
Sbjct: 380 MPPHGYTGPPRPPPYG-----YQRGPLPPPRPTPR-PPVPPRGP 417
Score = 55.8 bits (133), Expect = 3e-07
Identities = 63/209 (30%), Positives = 69/209 (33%), Gaps = 80/209 (38%)
Query: 1291 PPPPQQPPPL-PQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGG 1349
PPPP P P+ LGS PPP PP G P P + PG P
Sbjct: 215 PPPPSAPNPVVSSLGSGLPPPGMPPP----------GSFPPP----VPPPGALP------ 254
Query: 1350 HPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSR 1409
P P P P P P A GP +AG PG+
Sbjct: 255 --------------PGIP-PAMPPPPMPPGAAGHGPP---------------SAGTPGAG 284
Query: 1410 PPGGSYSHPH--------HP---QSPLSPHSPIP---PHPSYPPL---PPPSPHTPHSPL 1452
PG +SHPH HP Q L+ H P PH P PPP P
Sbjct: 285 HPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRP------- 337
Query: 1453 PPTSPHGPLHASGPPGTANPPSANPKAKP 1481
PP PH GPP PP P P
Sbjct: 338 PPGMPH-----PGPPPMGMPPRGPPFGSP 361
Score = 46.2 bits (108), Expect = 2e-04
Identities = 39/149 (26%), Positives = 60/149 (40%), Gaps = 30/149 (20%)
Query: 1334 YTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHH 1393
Y + + R G+ A ++PL Q P L++ AP PP P
Sbjct: 176 YAFKKDSKGERHGSAAERLLA--AQNPLSQADRPHQLFADAP--PPPSAPNP-------- 223
Query: 1394 PQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLP 1453
++ + G+ P PP GS+ P+PP + PP PP+ P P+P
Sbjct: 224 --VVSSLGSGLPPPGMPPPGSFP------------PPVPPPGALPPGIPPA--MPPPPMP 267
Query: 1454 P-TSPHGPLHASGPPGTANPPSANPKAKP 1481
P + HGP ++G PG +P + P
Sbjct: 268 PGAAGHGP-PSAGTPGAGHPGHGHSHPHP 295
Score = 42.0 bits (97), Expect = 0.004
Identities = 56/208 (26%), Positives = 70/208 (33%), Gaps = 48/208 (23%)
Query: 498 KRESKEQQEDSSAT---------SFSDLP--LYLDDTVPQQSPE----RLPSTEPPPQGR 542
K++SK ++ S+A S +D P L+ D P +P L S PPP
Sbjct: 179 KKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMP 238
Query: 543 PEFWAPAPLPPV------------PPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAH 590
P P P+PP PPP+P G G GT PG
Sbjct: 239 PPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGT---PGAGHPGHGHSHPHP 295
Query: 591 LPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGR-APIPHRHYP 649
P + P S + L+ G H H GPPG P R P
Sbjct: 296 FPPGGMPHPGMSQMQLAHHGPHGLGH----------------PHAGPPGSGGQPPPRPPP 339
Query: 650 APEGPAPAPPGPLPPAPNSGTGPSGVAG 677
P P P G P P G+ P G G
Sbjct: 340 GMPHPGPPPMGMPPRGPPFGS-PMGHPG 366
Score = 38.5 bits (88), Expect = 0.049
Identities = 47/156 (30%), Positives = 54/156 (34%), Gaps = 19/156 (12%)
Query: 529 PERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRA 588
P P PPP P PA P PP+P G G GT PG
Sbjct: 240 PGSFPPPVPPPGALPPGIPPAMPP---PPMPPGAAGHGPPSAGT---PGAGHPGHGHSHP 293
Query: 589 AHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGT----LKHKGPPGRAPIP 644
P + P S + L+ G H G P + H GPP +P
Sbjct: 294 HPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMG-MP 352
Query: 645 HRHYP--APEG-PAPAPP----GPLPPAPNSG-TGP 672
R P +P G P P PP GP P P G TGP
Sbjct: 353 PRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGP 388
Score = 31.6 bits (70), Expect = 6.0
Identities = 24/93 (25%), Positives = 31/93 (33%), Gaps = 3/93 (3%)
Query: 196 PRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSD 255
P PP G G + +PGAG + P G + ++ G
Sbjct: 262 PPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGH 321
Query: 256 LSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGV 288
G QPP R PP H G PP G+
Sbjct: 322 PHAGPPGSGGQPPPR---PPPGMPHPGPPPMGM 351
Score = 31.2 bits (69), Expect = 7.8
Identities = 38/137 (27%), Positives = 45/137 (32%), Gaps = 13/137 (9%)
Query: 1177 HQRMPPPPPPPPPEEYKSQRPVSNSSSF-LGSLFGSKRGKG-------PFQMP---PPPT 1225
H P PP P SQ +++ LG G G P MP PPP
Sbjct: 290 HSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPM 349
Query: 1226 GQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPP 1285
G S H HG G ++P Y GP PPP P
Sbjct: 350 GMPPRGPPFGSPMGHPGPMPPHG-MRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPR-PT 407
Query: 1286 QQPSLPPPPQQPPPLPQ 1302
+P +PP PLPQ
Sbjct: 408 PRPPVPPRGPLRGPLPQ 424
>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
sapiens]
Length = 1636
Score = 86.3 bits (212), Expect = 2e-16
Identities = 121/454 (26%), Positives = 157/454 (34%), Gaps = 83/454 (18%)
Query: 1067 QDRLRFTSDLRESIAEVQEMEKYRVES-ELEKQKGMMRPNASQPGGAKDSVNGTMARSSL 1125
Q+ F +DL +A + E + ++ E +Q+ + R +P + + R
Sbjct: 673 QEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREE 732
Query: 1126 EDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPP-- 1183
+ AGD LR L G R L S SP P P P
Sbjct: 733 SEAVEAGDP------PEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHY 786
Query: 1184 -PPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHH 1242
P PP Y + R GP MP P G A + + +
Sbjct: 787 LSGPLPPGTYSGPTQLIQP-----------RAPGPHAMPVAP-GPALYPAPAYTPE---- 830
Query: 1243 HHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPP----PYLPPQQPSLP------- 1291
LG++P + + + Y G GPAPP P PP Q S P
Sbjct: 831 -----------LGLVPRSSPQHGVVSSPYV-GVGPAPPVAGLPSAPPPQFSGPELAMAVR 878
Query: 1292 -----------PPPQQPPPLPQLGSIPPPPA-SAPPVGPHRHFH-----AHGPVPGPQHY 1334
P P P P PPPP PP P + A P+P H+
Sbjct: 879 PATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHF 938
Query: 1335 TLGRPGRAPRRGAGGHPQFAPHGR-HPLHQ-----PTSPLPLYSPAPQHPPAHKQGPKHF 1388
+ G P P G PQ PH + HP P PLPL P P A P
Sbjct: 939 SSGIPAGFPAPRIGPQPQ--PHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQS 996
Query: 1389 IFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTP 1448
+ + PQ G G P PP + +P Q PL HS P PS P PP P
Sbjct: 997 PYPYAPQ----PGVLGQPP--PPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLA 1050
Query: 1449 HSPLPPTSPHGPLHASGPPGTANPPSANPKAKPS 1482
+ P P T P GP A P T PS+ ++ PS
Sbjct: 1051 YGPAPSTRPMGPQAA---PLTIRGPSSAGQSTPS 1081
Score = 69.3 bits (168), Expect = 3e-11
Identities = 95/351 (27%), Positives = 119/351 (33%), Gaps = 71/351 (20%)
Query: 1164 STIEGSVISSPR-------PHQRMPPPPPPP--PPEEYKSQRPVSNSSSFLGSLFGSKRG 1214
S+ + V+SSP P +P PPP PE + RP + + + + S
Sbjct: 837 SSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTA 896
Query: 1215 KGP----------FQMPPP-PTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSK 1263
P F +PPP P + A HH G +P G
Sbjct: 897 PRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSG--------IPAGFPA 948
Query: 1264 LQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPP-PASAPPVGPHRHF 1322
+ GP P P P P Q P PPQQP PL PP P PP P+
Sbjct: 949 PRI-------GPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPY--- 998
Query: 1323 HAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPH-GRHPLHQPTSPLPLYSPAPQHPPAH 1381
+ P PG LG+P H Q P + PL + LP SP P PP
Sbjct: 999 -PYAPQPG----VLGQPPPPL------HTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHP 1047
Query: 1382 K--QGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPP 1439
GP PQ P GP S G S PH SP P P P P
Sbjct: 1048 PLAYGPAPSTRPMGPQAAPLT--IRGPSSA--GQSTPSPHLVPSPAPSPGPGPVPPRPPA 1103
Query: 1440 LPPP------SPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRI 1484
PP + P S HG GT +P P +P+++
Sbjct: 1104 AEPPPCLRRGAAAADLLSSSPESQHG--------GTQSPGGGQPLLQPTKV 1146
Score = 45.1 bits (105), Expect = 5e-04
Identities = 68/264 (25%), Positives = 83/264 (31%), Gaps = 38/264 (14%)
Query: 1153 RGRRNSVGSLDSTIEGSVISSPRPHQRMPPP-----PPPPPPEEYK----SQRPVSNSSS 1203
R +V S+ + I P P PPP PP P P Y +++P+
Sbjct: 878 RPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHH 937
Query: 1204 FLGSL---FGSKR-GKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGL----- 1254
F + F + R G P P P QA H H + G L
Sbjct: 938 FSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSP 997
Query: 1255 -------GVLPDGQSKLQALHAQYCQGPGPAPPPY----LPPQQPSLPPPPQQPPPLPQL 1303
GVL GQ LH Q GP P P LP P P PP P
Sbjct: 998 YPYAPQPGVL--GQPP-PPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPA 1054
Query: 1304 GSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHP--L 1361
S P A P+ A P P P AP G G P P P L
Sbjct: 1055 PSTRPMGPQAAPLTIRGPSSAGQSTPSPHLV----PSPAPSPGPGPVPPRPPAAEPPPCL 1110
Query: 1362 HQPTSPLPLYSPAPQHPPAHKQGP 1385
+ + L S +P+ Q P
Sbjct: 1111 RRGAAAADLLSSSPESQHGGTQSP 1134
Score = 39.7 bits (91), Expect = 0.022
Identities = 21/44 (47%), Positives = 21/44 (47%), Gaps = 2/44 (4%)
Query: 1275 PGPAPPPYLPPQQ--PSLPPPPQQPPPLPQLGSIPPPPASAPPV 1316
PGPA PP LPP S P P PPPL P P PPV
Sbjct: 1521 PGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPV 1564
Score = 37.0 bits (84), Expect = 0.14
Identities = 26/72 (36%), Positives = 31/72 (43%), Gaps = 13/72 (18%)
Query: 1409 RPPGGSYSH----------PHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPH 1458
RPPGG S P P + L +PIP S PPL P P P P P
Sbjct: 1508 RPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSS-SPPPLSSPLPEAPQPKEEPPVPE 1566
Query: 1459 GPLHASGPPGTA 1470
P +SGPP ++
Sbjct: 1567 AP--SSGPPSSS 1576
>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
isoform b [Homo sapiens]
Length = 513
Score = 84.3 bits (207), Expect = 8e-16
Identities = 50/142 (35%), Positives = 80/142 (56%), Gaps = 6/142 (4%)
Query: 800 RQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 859
R + + LG + +F++ V + + DF+ M LD +LR F + GE Q+ ER++
Sbjct: 66 RSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIH 124
Query: 860 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVD 919
FS RY CNP + + D + L AI+LLNTD++ ++ +KM +FI NL+GV+
Sbjct: 125 FSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMTCQEFIANLQGVN 179
Query: 920 NGEDIPRDLLVGIYQRIQGREL 941
G D +DLL +Y I+ +L
Sbjct: 180 EGVDFSKDLLKALYNSIKNEKL 201
>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
isoform a [Homo sapiens]
Length = 1047
Score = 84.3 bits (207), Expect = 8e-16
Identities = 50/142 (35%), Positives = 80/142 (56%), Gaps = 6/142 (4%)
Query: 800 RQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 859
R + + LG + +F++ V + + DF+ M LD +LR F + GE Q+ ER++
Sbjct: 600 RSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIH 658
Query: 860 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVD 919
FS RY CNP + + D + L AI+LLNTD++ ++ +KM +FI NL+GV+
Sbjct: 659 FSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMTCQEFIANLQGVN 713
Query: 920 NGEDIPRDLLVGIYQRIQGREL 941
G D +DLL +Y I+ +L
Sbjct: 714 EGVDFSKDLLKALYNSIKNEKL 735
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 84.0 bits (206), Expect = 1e-15
Identities = 66/200 (33%), Positives = 78/200 (39%), Gaps = 35/200 (17%)
Query: 1289 SLPPPPQQ-----PPPLPQLGSIPPPPAS-APPVGPHRHFHAHGPVPGPQHYTLGRPGRA 1342
S PPPPQ P P ++PPPPA + PV R + GP+ ++ P
Sbjct: 245 SYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRG----SGLAGPKRSSVVSPS-- 298
Query: 1343 PRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGA 1402
HP AP PL P P P ++P P PP P I P P
Sbjct: 299 -------HPPPAP----PLGSPPGPKPGFAPPPAPPPP----PPPMIGIPPP---PPPVG 340
Query: 1403 AGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLH 1462
G PG+ PP S P HP P P PP YP LPPP P PP P P
Sbjct: 341 FGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPP-- 398
Query: 1463 ASGPPGTANPPSANPKAKPS 1482
PPG PP +P+
Sbjct: 399 ---PPGPPPPPFTGADGQPA 415
Score = 72.4 bits (176), Expect = 3e-12
Identities = 75/244 (30%), Positives = 89/244 (36%), Gaps = 65/244 (26%)
Query: 1222 PPPTGQASASSSSASSTHHH-----HHHHHHGHSHGGLGVL-PDGQSKLQALHAQYCQGP 1275
PPP SASS S S + + + + G G+ P S + H P
Sbjct: 247 PPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSH------P 300
Query: 1276 GPAPPPYLPP-QQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHY 1334
PAPP PP +P PPP PPP P + IPPPP PPVG
Sbjct: 301 PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPP---PPVG----------------- 340
Query: 1335 TLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHP 1394
G PG P P F PH P P P P PPA + +P
Sbjct: 341 -FGSPGTPP---PPSPPSFPPH-------PDFAAP---PPPPPPPA----------ADYP 376
Query: 1395 QMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHT--PHSPL 1452
+ P P S+P GG+ P P P P P P +PPP T P S L
Sbjct: 377 TLPPP------PLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPLSDTTKPKSSL 430
Query: 1453 PPTS 1456
P S
Sbjct: 431 PAVS 434
Score = 53.9 bits (128), Expect = 1e-06
Identities = 53/197 (26%), Positives = 56/197 (28%), Gaps = 81/197 (41%)
Query: 1181 PPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHH 1240
PPP PPPPP P PPPP G S +
Sbjct: 318 PPPAPPPPPPPMIGIPP-----------------------PPPPVGFGSPGT-------- 346
Query: 1241 HHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPL 1300
P P PP PP PPP PPP
Sbjct: 347 ----------------------------------PPPPSPPSFPPHPDFAAPPPPPPPPA 372
Query: 1301 PQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHP 1360
++PPPP S P G P P P G P P GA G P P P
Sbjct: 373 ADYPTLPPPPLSQPTGG--------APPPPPPPPPPG-PPPPPFTGADGQPAIPP----P 419
Query: 1361 LHQPTSP---LPLYSPA 1374
L T P LP S A
Sbjct: 420 LSDTTKPKSSLPAVSDA 436
Score = 52.8 bits (125), Expect = 3e-06
Identities = 40/124 (32%), Positives = 50/124 (40%), Gaps = 9/124 (7%)
Query: 1364 PTSPLPLYSPAPQHPPAHKQGPKH--FIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHP 1421
P P P + GPK + HP P G+ GP PG ++ P P
Sbjct: 268 PPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHPPPAPPLGSPPGP---KPG--FAPPPAP 322
Query: 1422 QSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKP 1481
P P IPP P PP+ SP TP P PP+ P P A+ PP P + P P
Sbjct: 323 PPPPPPMIGIPPPP--PPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPP 380
Query: 1482 SRIS 1485
+S
Sbjct: 381 PPLS 384
Score = 38.1 bits (87), Expect = 0.064
Identities = 36/148 (24%), Positives = 42/148 (28%), Gaps = 68/148 (45%)
Query: 1174 PRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSS 1233
P P PPPPPPPP +Y + P S G P PPPP
Sbjct: 357 PHPDFAAPPPPPPPPAADYPTLPPPPLS---------QPTGGAPPPPPPPPP-------- 399
Query: 1234 SASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQ-QPSLPP 1292
PGP PPP+ QP++PP
Sbjct: 400 -----------------------------------------PGPPPPPFTGADGQPAIPP 418
Query: 1293 PPQQPPPLPQLGSIPPPPASAPPVGPHR 1320
P L P +S P V R
Sbjct: 419 P---------LSDTTKPKSSLPAVSDAR 437
Score = 35.4 bits (80), Expect = 0.41
Identities = 20/52 (38%), Positives = 23/52 (44%), Gaps = 1/52 (1%)
Query: 509 SATSFSDLPLYLDDTVPQQSPER-LPSTEPPPQGRPEFWAPAPLPPVPPPVP 559
S SF P + P P P+ PPP +P AP P PP PPP P
Sbjct: 351 SPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGP 402
>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
Length = 1056
Score = 83.2 bits (204), Expect = 2e-15
Identities = 54/177 (30%), Positives = 91/177 (51%), Gaps = 11/177 (6%)
Query: 796 KGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVER 855
+G + + +L + F+R V + + F LD ALR F + + GE Q+ ER
Sbjct: 599 EGFRKSEVAAYL-QKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERER 657
Query: 856 LIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNL 915
++ FS+R+ CNP + F + D++ L AI+LLNTD++ ++ + M +FI NL
Sbjct: 658 ILYQFSRRFHHCNPGI---FPSVDSVHTLTCAIMLLNTDLHGQNI--GKSMSCQEFITNL 712
Query: 916 RGVDNGEDIPRDLLVGIYQRIQGRELR---TNDDHVSQVQAVERMIVGK--KPVLSL 967
G+ +G + P++LL +Y I+ +L +D +A + GK KP L L
Sbjct: 713 NGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQL 769
>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
preproprotein [Homo sapiens]
Length = 331
Score = 82.4 bits (202), Expect = 3e-15
Identities = 103/359 (28%), Positives = 121/359 (33%), Gaps = 67/359 (18%)
Query: 1140 LSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVS 1199
LS +L LS A S S I G+ P P P PPPPP + + P
Sbjct: 6 LSVALLALSSAQNLNEDVSQEESPSLIAGNP-QGPSPQGGNKPQGPPPPPGKPQGPPPQG 64
Query: 1200 NSSSFLGSLFGSKRGKGPFQMP--PPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVL 1257
+ +G P P PPP G S S S G
Sbjct: 65 GNKP---------QGPPPPGKPQGPPPQGDKSRSPRSPPGKPQ--------------GPP 101
Query: 1258 PDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIP--PP--PASA 1313
P G ++ Q + GP P PQ P P PQ PPP P PP P
Sbjct: 102 PQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGP 161
Query: 1314 PPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPL--Y 1371
PP G ++ GP P P G+P P +G G PQ P P +P P P
Sbjct: 162 PPQGGNQ---PQGPPPPP-----GKPQGPPPQG-GKKPQGPP----PPGKPQGPPPQGDK 208
Query: 1372 SPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPI 1431
S + Q PP QGP P G G PP G P PQ P P
Sbjct: 209 SRSSQSPPGKPQGP------------PPQGGNQPQGPPPPPGKPQGP-PPQGGNKPQGPP 255
Query: 1432 PPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASG-------PPGTANP--PSANPKAKP 1481
PP P + + PP P GP G PP NP P A P +P
Sbjct: 256 PPGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQP 314
Score = 78.6 bits (192), Expect = 4e-14
Identities = 83/254 (32%), Positives = 96/254 (37%), Gaps = 57/254 (22%)
Query: 1273 QGPGPAP--PPYLPPQ---QPSLPPP---PQQPPPLPQLGSIP--PP--PASAPPVGPHR 1320
QGP P P P PPQ +P PPP PQ PPP P PP P PP G ++
Sbjct: 48 QGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQ 107
Query: 1321 HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPL--YSPAPQHP 1378
GP P P G+P P +G G PQ P P +P P P S +P+ P
Sbjct: 108 ---PQGPPPPP-----GKPQGPPPQG-GNRPQGPP----PPGKPQGPPPQGDKSRSPRSP 154
Query: 1379 PAHKQGPKHFIFSH---------HPQMMPAAGAAGGPGSRPPG-------------GSYS 1416
P QGP + PQ P G G PPG S S
Sbjct: 155 PGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQS 214
Query: 1417 HPHHPQSP-----LSPHSPIPPHPSYPPLPPP-SPHTPHSPLPPTSPHGPLHASGPPG-T 1469
P PQ P P P PP P P PPP + P P PP P GP G +
Sbjct: 215 PPGKPQGPPPQGGNQPQGP-PPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQS 273
Query: 1470 ANPPSANPKAKPSR 1483
A P P+ P +
Sbjct: 274 ARSPPGKPQGPPQQ 287
Score = 73.2 bits (178), Expect = 2e-12
Identities = 69/211 (32%), Positives = 74/211 (35%), Gaps = 33/211 (15%)
Query: 1281 PYLPPQQPSLPPP-----PQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYT 1335
P L P P P PQ PPP P PPP P GP GP P
Sbjct: 29 PSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQ----- 83
Query: 1336 LGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQ 1395
G R+PR G P G + QP P P PP QGP + PQ
Sbjct: 84 -GDKSRSPRSPPGKPQGPPPQGGN---QPQGPPP--------PPGKPQGPPPQ-GGNRPQ 130
Query: 1396 MMPAAGAAGGPGSRPPGGSYSH-PHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPP 1454
P G GP PP G S P P P P P P + P PPP P P P
Sbjct: 131 GPPPPGKPQGP---PPQGDKSRSPRSP--PGKPQGPPPQGGNQPQGPPPPPGKPQGP--- 182
Query: 1455 TSPHGPLHASGPPGTANPPSANPKAKPSRIS 1485
P G GPP P P+ SR S
Sbjct: 183 -PPQGGKKPQGPPPPGKPQGPPPQGDKSRSS 212
Score = 55.1 bits (131), Expect = 5e-07
Identities = 72/239 (30%), Positives = 83/239 (34%), Gaps = 80/239 (33%)
Query: 1167 EGSVISSPRPHQRMPPPPPP--------PPPEEYKSQRPVSNSSSFLGSLFGSKRGKGP- 1217
+G SPR P PPP PPP K Q P G K+ +GP
Sbjct: 144 QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ---------GGKKPQGPP 194
Query: 1218 ---FQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQG 1274
PPP G S SS S G P G ++ Q
Sbjct: 195 PPGKPQGPPPQGDKSRSSQSPPGKPQ--------------GPPPQGGNQPQ--------- 231
Query: 1275 PGPAPPPYLP----PQ---QPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGP 1327
GP PPP P PQ +P PPPP +P P G A +PP P GP
Sbjct: 232 -GPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGKP------QGP 284
Query: 1328 VPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPA--PQHPPAHKQG 1384
PQ G + P AGG+PQ QP +P PA PQ PP QG
Sbjct: 285 ---PQQE--GNNPQGPPPPAGGNPQ----------QPQAP-----PAGQPQGPPRPPQG 323
Score = 44.7 bits (104), Expect = 7e-04
Identities = 46/162 (28%), Positives = 55/162 (33%), Gaps = 49/162 (30%)
Query: 525 PQQSPERLPSTEP------PPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGP 576
PQ R P + P PPQG +P+ P P P PP G R G G +G
Sbjct: 82 PQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQG- 140
Query: 577 GCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKG 636
PP S RS G + G P G + +G
Sbjct: 141 ---------------------PPPQGDKSRSPRSPPG--------KPQGPPPQGGNQPQG 171
Query: 637 PPGRAPIPHRHYPAPEGPAP----APPGPLPPAPNSGTGPSG 674
PP P P + P+GP P P GP PP G P G
Sbjct: 172 PP---PPPGK----PQGPPPQGGKKPQGPPPPGKPQGPPPQG 206
Score = 42.4 bits (98), Expect = 0.003
Identities = 43/162 (26%), Positives = 56/162 (34%), Gaps = 45/162 (27%)
Query: 521 DDTVPQQSPERLPSTE--PPPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGP 576
+D ++SP + P PQG +P+ P P P PP G + G G +G
Sbjct: 21 EDVSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG- 79
Query: 577 GCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKG 636
PP S RS G + G P G + +G
Sbjct: 80 ---------------------PPPQGDKSRSPRSPPG--------KPQGPPPQGGNQPQG 110
Query: 637 PPGRAPIPHRHYPAPEGPAP----APPGPLPPAPNSGTGPSG 674
PP P P + P+GP P P GP PP G P G
Sbjct: 111 PP---PPPGK----PQGPPPQGGNRPQGPPPPGKPQGPPPQG 145
Score = 38.9 bits (89), Expect = 0.037
Identities = 43/160 (26%), Positives = 55/160 (34%), Gaps = 44/160 (27%)
Query: 521 DDTVPQQSPERLPSTEPPPQG--RPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGC 578
D + +SP P PPPQG +P+ P P P PP G + G G +G
Sbjct: 146 DKSRSPRSPPGKPQ-GPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQG--- 201
Query: 579 LECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPP 638
PP S +S G + G P G + +GPP
Sbjct: 202 -------------------PPPQGDKSRSSQSPPG--------KPQGPPPQGGNQPQGPP 234
Query: 639 GRAPIPHRHYPAPEGPAP----APPGPLPPAPNSGTGPSG 674
P P + P+GP P P GP PP G G
Sbjct: 235 ---PPPGK----PQGPPPQGGNKPQGPPPPGKPQGPPAQG 267
Score = 33.1 bits (74), Expect = 2.1
Identities = 35/134 (26%), Positives = 42/134 (31%), Gaps = 29/134 (21%)
Query: 1174 PRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPP-----PTGQA 1228
P P P PPPPP + + P G + +GP PPP P Q
Sbjct: 222 PPPQGGNQPQGPPPPPGKPQGPPPQ-----------GGNKPQGP---PPPGKPQGPPAQG 267
Query: 1229 SASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQP 1288
+ S SA S + G P Q P PP PQ P
Sbjct: 268 GSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQ----------PQAPPAGQPQGP 317
Query: 1289 SLPPPPQQPPPLPQ 1302
PP +P PQ
Sbjct: 318 PRPPQGGRPSRPPQ 331
Score = 32.3 bits (72), Expect = 3.5
Identities = 32/100 (32%), Positives = 40/100 (40%), Gaps = 15/100 (15%)
Query: 483 PSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGR 542
P GP PG K + Q D S +S S P P Q + P PPP G+
Sbjct: 190 PQGP--PPPG-----KPQGPPPQGDKSRSSQS--PPGKPQGPPPQGGNQ-PQGPPPPPGK 239
Query: 543 PEFWAPA----PLPPVPPPVPSG-TREDGSREEGTRRGPG 577
P+ P P P PP P G + GS+ + R PG
Sbjct: 240 PQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPG 279
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 855
Score = 81.6 bits (200), Expect = 5e-15
Identities = 100/337 (29%), Positives = 122/337 (36%), Gaps = 90/337 (26%)
Query: 1172 SSPRPHQRMPPPPPPPPPEEYKS--QRPVSNSSSFLGSLFGSKRGKGPFQMPP------- 1222
S+P Q +P PP PP + S + + SFL S S P Q PP
Sbjct: 346 SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL 405
Query: 1223 --PPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPP 1280
PP+ AS S ++ P + L Q P P+PP
Sbjct: 406 QAPPSPPASPPLSPLATPS------------------PQAPNALAVHLLQAPFSPPPSPP 447
Query: 1281 -------PYLPPQQPSLPPPPQQPPPL--PQLGSIPPPPASAPPVGPHRHFHAHGPVPGP 1331
P PP PS PP Q PP L P L +PP P ++PP+ P P P
Sbjct: 448 VQAPFSPPASPPVSPSATPPSQAPPSLAAPPL-QVPPSPPASPPMSP-------SATPPP 499
Query: 1332 QHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFS 1391
Q AP PL P PL L P PQ PPA P
Sbjct: 500 Q---------AP---------------PPLAAP--PLQLAKPPPQAPPALATPPL----- 528
Query: 1392 HHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSP---IPPHPSYPPLPPPS---- 1444
Q +P+ A PG P S S P P + P +P P PP PP S
Sbjct: 529 ---QALPSP-PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 584
Query: 1445 -PHTPHSPLPPTSPHGP-LHASGPPGTANPPSANPKA 1479
P P +P P TS GP L + PG PPS +P +
Sbjct: 585 APRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 621
Score = 75.1 bits (183), Expect = 5e-13
Identities = 107/409 (26%), Positives = 139/409 (33%), Gaps = 63/409 (15%)
Query: 1097 KQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRR 1156
+ G RP G + S T+AR A + KR ALS+ R + G
Sbjct: 119 RASGTTRPGPLGQKGLRISAEETVARGK------ATEAPKRSALSAGARRDTSGPTPGTP 172
Query: 1157 NSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKG 1216
+ + S G+ + PRP P PP P KS S S+ S +R
Sbjct: 173 SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR--KSVSSASEHSTTEPSPAARRRPSA 230
Query: 1217 PFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPG 1276
+ P + S+S++ SS G S G P S+ + Q + P
Sbjct: 231 GGGLQRPASRSLSSSATPLSSPARS------GPSARGTPRAPAHPSQPKPKGLQALRPPQ 284
Query: 1277 PAPP--PYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVP----- 1329
PP P P P P P L S PP A P P+P
Sbjct: 285 VTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPS 344
Query: 1330 ---GPQHYTLGRPGRAPRRGAG---GHPQF-APHGRHPLHQPTSPL-PLYSPAPQHPPAH 1381
P TL P P A G P A H P+ PL PL +P PQ PPA
Sbjct: 345 PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHS----FLPSPPLSPLATPPPQAPPA- 399
Query: 1382 KQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSP--------LSPHSPIPP 1433
+P A P + PP + P PQ+P +P SP P
Sbjct: 400 -------------LALPPLQAPPSPPASPPLSPLATPS-PQAPNALAVHLLQAPFSPPPS 445
Query: 1434 HPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPS 1482
P P PP+ PP SP + PP A PP P + P+
Sbjct: 446 PPVQAPFSPPAS-------PPVSPSATPPSQAPPSLAAPPLQVPPSPPA 487
Score = 68.6 bits (166), Expect = 4e-11
Identities = 82/307 (26%), Positives = 107/307 (34%), Gaps = 55/307 (17%)
Query: 1176 PHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSA 1235
P +PP PP P P++ S + + PF PP P QA S ++
Sbjct: 398 PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 457
Query: 1236 SSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQ 1295
P Q+ +L A Q P PP PP PS PPPQ
Sbjct: 458 PPVSP--------------SATPPSQAP-PSLAAPPLQVP--PSPPASPPMSPSATPPPQ 500
Query: 1296 QPPPL--PQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQF 1353
PPPL P L PPP + P + A P+ PG+AP F
Sbjct: 501 APPPLAAPPLQLAKPPPQAPPAL-------ATPPLQALPSPPASFPGQAP---------F 544
Query: 1354 APHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGG 1413
+P P+ PL +P PQ PP P PA+ P P G
Sbjct: 545 SPSASLPMS------PLATPPPQAPPVLAAP-----LLQVPPSPPASPTLQAPRRPPTPG 593
Query: 1414 SYSHPHHPQSPLSPHSPIPPHPSYPPL-----PPPSPHTPHSPLPPTSPHGPLHASGPPG 1468
+ P+ L+ PP PS P P + H+ + P G + SGP G
Sbjct: 594 PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRG--YDSGPEG 651
Query: 1469 --TANPP 1473
A+PP
Sbjct: 652 GAAASPP 658
Score = 46.2 bits (108), Expect = 2e-04
Identities = 71/254 (27%), Positives = 90/254 (35%), Gaps = 41/254 (16%)
Query: 1176 PHQRMPPPPPPPPPEEYKSQRPVSN-SSSFLGSLFGSKRGKGPFQMPPPPTGQASAS--- 1231
P ++PP PP P + + P +S G GP PPPP+ S++
Sbjct: 569 PLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP---PPPPSRSPSSTLSG 625
Query: 1232 ------SSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALH-AQYCQGPGPAPPPYLP 1284
SSSA+ST + G GG P ++L A H A + +GP P P +
Sbjct: 626 PDLAGHSSSATSTPEELRGYDSG-PEGGAAASPPPDAELAACHPAAWSRGPAP-PLAFRG 683
Query: 1285 PQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV-PGPQHYTLGRPGRAP 1343
LP PP P GS GP A G + PGP T G A
Sbjct: 684 APGAPLPWPPATGP-----GSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAA- 737
Query: 1344 RRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAA 1403
GAG R P LPL A + + S + A GAA
Sbjct: 738 --GAGA----GASSRSPKQARLGELPL--------GALQASVVQHLLSRTLLLAAAEGAA 783
Query: 1404 G----GPGSRPPGG 1413
G GPG GG
Sbjct: 784 GGSGGGPGGAEGGG 797
Score = 44.7 bits (104), Expect = 7e-04
Identities = 69/244 (28%), Positives = 84/244 (34%), Gaps = 51/244 (20%)
Query: 1171 ISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASA 1230
+S PR + P PPPPP S+ P S S GP +
Sbjct: 598 VSGPRLTLALAPGPPPPP-----SRSPSSTLS-------------GP---------DLAG 630
Query: 1231 SSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALH-AQYCQGPGPAPPPYLPPQQPS 1289
SSSA+ST + G GG P ++L A H A + +GP P P +
Sbjct: 631 HSSSATSTPEELRGYDSG-PEGGAAASPPPDAELAACHPAAWSRGPAP-PLAFRGAPGAP 688
Query: 1290 LPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV-PGPQHYTLGRPGRAPRRGAG 1348
LP PP P GS GP A G + PGP T G A GAG
Sbjct: 689 LPWPPATGP-----GSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAA---GAG 740
Query: 1349 GHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGS 1408
R P LPL A + + S + A GAAGG G
Sbjct: 741 A----GASSRSPKQARLGELPL--------GALQASVVQHLLSRTLLLAAAEGAAGGSGG 788
Query: 1409 RPPG 1412
P G
Sbjct: 789 GPGG 792
Score = 35.8 bits (81), Expect = 0.32
Identities = 48/196 (24%), Positives = 59/196 (30%), Gaps = 35/196 (17%)
Query: 478 ALNCHPSGPMSEEPGSAQ----LEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLP 533
+L C + P+ P S L+ S S AT+ P SP P
Sbjct: 329 SLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP 388
Query: 534 STEPPPQGRPEFWAPA----PLPPVPPPV-PSGTREDGSREEGTRRGPGCLECRDFRLRA 588
PPPQ P P P PP PP+ P T + P L A
Sbjct: 389 LATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSP--------QAPNAL--------A 432
Query: 589 AHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHY 648
HL PP V + SP T + PP A P +
Sbjct: 433 VHLLQAPFSPPPSPPVQAPFSPPA----------SPPVSPSATPPSQAPPSLAAPPLQVP 482
Query: 649 PAPEGPAPAPPGPLPP 664
P+P P P PP
Sbjct: 483 PSPPASPPMSPSATPP 498
Score = 35.4 bits (80), Expect = 0.41
Identities = 27/80 (33%), Positives = 37/80 (46%), Gaps = 8/80 (10%)
Query: 649 PAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNET 708
P P G +P PP P+ PA G +G G + L E AG ES + +
Sbjct: 27 PRPPG-SPRPPPPVTPAALRVLGAAGAVGRKPL--AERAGGIGGATIPESAPRAGPTR-- 81
Query: 709 INCSSGSSSRDSLREPPATG 728
S+G+SSR+ PPA+G
Sbjct: 82 ---SAGTSSRNPASRPPASG 98
Score = 35.4 bits (80), Expect = 0.41
Identities = 44/162 (27%), Positives = 57/162 (35%), Gaps = 23/162 (14%)
Query: 167 GRERGGREAGPAHPGREKEAGYSAAVGVGPRPPRE-----RGQLSRGASRSSSPGA---- 217
G G PAHP + K G A PPR+ G LS + SP A
Sbjct: 256 GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQS 315
Query: 218 -------GGGHSTSTSTSPATTL----QRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQ 266
HS+S + AT L S + +T+ P S +T++ SP Q
Sbjct: 316 QAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQ 375
Query: 267 PPYRLSQLPPSSSHMGGP---PAGVGLPWAQRARLQPASVAL 305
+ PP S P P + LP Q PAS L
Sbjct: 376 ATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 417
Score = 34.7 bits (78), Expect = 0.71
Identities = 48/162 (29%), Positives = 55/162 (33%), Gaps = 24/162 (14%)
Query: 525 PQQSPERLPSTEPPPQGRPEFWAP----APLPPVPPPVPSGTREDGSREEGTRRGPGCLE 580
P S P PPPQ P AP P PP P + + R + + GP
Sbjct: 546 PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGP---- 601
Query: 581 CRDFRLRAAHLPLLTIEPPSDSSVDLS--DRSDRGSVHRQLVYEADG--CSPHGTLKHKG 636
RL A P P S LS D + S E G P G
Sbjct: 602 ----RLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAA-AS 656
Query: 637 PPGRAPIPHRHYPA-PEGPAP------APPGPLPPAPNSGTG 671
PP A + H A GPAP AP PLP P +G G
Sbjct: 657 PPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG 698
Score = 32.7 bits (73), Expect = 2.7
Identities = 28/92 (30%), Positives = 32/92 (34%), Gaps = 4/92 (4%)
Query: 470 SLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSP 529
+LA + +A P P + P S S S A P P SP
Sbjct: 430 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 489
Query: 530 ERLPSTEPPPQGRPEFWAP----APLPPVPPP 557
PS PPPQ P AP A PP PP
Sbjct: 490 PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPP 521
Score = 31.6 bits (70), Expect = 6.0
Identities = 58/215 (26%), Positives = 77/215 (35%), Gaps = 30/215 (13%)
Query: 523 TVPQQSPE-----------RLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEG 571
T+P+ +P R P++ PP GR E AP P PV S R G+
Sbjct: 69 TIPESAPRAGPTRSAGTSSRNPASRPPASGRGE-RAPPAKNTSPGPVSSPGRASGT---- 123
Query: 572 TRRGPGCLECRDFRLRAAHLPL--LTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPH 629
TR GP L + R+ A E P S++ R D A
Sbjct: 124 TRPGP--LGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181
Query: 630 GTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGE 689
G P AP R P EGP + + +S T PS A R +AG
Sbjct: 182 AAGTEVGLPRPAP-SARPRPPTEGPRKSVSS---ASEHSTTEPSPAARRR-----PSAGG 232
Query: 690 NSDGGDNESLESSSNSNETINCSSGSSSRDSLREP 724
+ SL SS+ + SG S+R + R P
Sbjct: 233 GLQRPASRSLSSSATPLSS-PARSGPSARGTPRAP 266
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,092,457
Number of Sequences: 37866
Number of extensions: 5695336
Number of successful extensions: 112934
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 948
Number of HSP's successfully gapped in prelim test: 1958
Number of HSP's that attempted gapping in prelim test: 35883
Number of HSP's gapped (non-prelim): 42802
length of query: 1488
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1373
effective length of database: 13,892,928
effective search space: 19074990144
effective search space used: 19074990144
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.