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Search of human proteins with 153791372
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
(490 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 1033 0.0
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 1033 0.0
gi|47717134 CDC-like kinase 2 [Homo sapiens] 598 e-171
gi|10190706 CDC-like kinase 4 [Homo sapiens] 514 e-146
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 483 e-136
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 483 e-136
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 204 2e-52
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 192 4e-49
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 192 4e-49
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 187 2e-47
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 187 2e-47
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 182 6e-46
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 180 2e-45
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 177 1e-44
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 176 3e-44
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 171 1e-42
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 171 1e-42
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 171 1e-42
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 171 1e-42
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 155 1e-37
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 151 1e-36
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 151 1e-36
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 145 8e-35
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 145 8e-35
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 142 5e-34
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 142 5e-34
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 141 1e-33
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 132 5e-31
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 132 5e-31
gi|27477122 intestinal cell kinase [Homo sapiens] 118 1e-26
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 1033 bits (2672), Expect = 0.0
Identities = 490/490 (100%), Positives = 490/490 (100%)
Query: 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRR 60
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRR
Sbjct: 149 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRR 208
Query: 61 YRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSS 120
YRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSS
Sbjct: 209 YRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSS 268
Query: 121 ASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGK 180
ASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGK
Sbjct: 269 ASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGK 328
Query: 181 SQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLG 240
SQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLG
Sbjct: 329 SQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLG 388
Query: 241 KNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLY 300
KNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLY
Sbjct: 389 KNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLY 448
Query: 301 NEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSI 360
NEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSI
Sbjct: 449 NEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSI 508
Query: 361 GCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 420
GCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD
Sbjct: 509 GCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 568
Query: 421 GRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER 480
GRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER
Sbjct: 569 GRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER 628
Query: 481 SFHTSRNPSR 490
SFHTSRNPSR
Sbjct: 629 SFHTSRNPSR 638
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 1033 bits (2672), Expect = 0.0
Identities = 490/490 (100%), Positives = 490/490 (100%)
Query: 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRR 60
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRR
Sbjct: 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRR 60
Query: 61 YRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSS 120
YRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSS
Sbjct: 61 YRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSS 120
Query: 121 ASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGK 180
ASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGK
Sbjct: 121 ASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGK 180
Query: 181 SQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLG 240
SQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLG
Sbjct: 181 SQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLG 240
Query: 241 KNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLY 300
KNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLY
Sbjct: 241 KNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLY 300
Query: 301 NEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSI 360
NEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSI
Sbjct: 301 NEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSI 360
Query: 361 GCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 420
GCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD
Sbjct: 361 GCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 420
Query: 421 GRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER 480
GRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER
Sbjct: 421 GRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER 480
Query: 481 SFHTSRNPSR 490
SFHTSRNPSR
Sbjct: 481 SFHTSRNPSR 490
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 598 bits (1542), Expect = e-171
Identities = 300/500 (60%), Positives = 370/500 (74%), Gaps = 12/500 (2%)
Query: 1 MHHCKRYRSPEP-------DPYLSYRWKRRRSYS-REHEGRLRYPSRREPPPRRSRSRSH 52
M H +RY S E + Y S + KRRRS S R R R + RSRS S+
Sbjct: 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRS-SY 59
Query: 53 DRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHK 112
D RR +RR +YR + S G+ YY RE YR+++ + H+
Sbjct: 60 DDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHR 119
Query: 113 RRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVE 172
RR R S SRS S R ++SVEDD EGHL+ +GDWLQERYEIV LGEGTFG+VV+
Sbjct: 120 RRRRR-SRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQ 178
Query: 173 CLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHM 232
C+DH RG ++VALKII+NV KY+EAARLEINVL+KI EKD +NK LCV M DWF++HGHM
Sbjct: 179 CVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHM 238
Query: 233 CIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFV 292
CI+FELLG +TF+FLK+NN+ PYP+ VRHMA+QLC A++FLH+N+LTHTDLKPENILFV
Sbjct: 239 CISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV 298
Query: 293 NSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWA 352
NS++E YN K +E+SVK+T++RV DFGSATFDHEHH+TIV+TRHYR PEVILELGW+
Sbjct: 299 NSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWS 358
Query: 353 QPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGL 412
QPCDVWSIGCI+FEYY GFTLFQTH+NREHL MME+ILGPIPS MI +TRKQKYFY+G L
Sbjct: 359 QPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRL 418
Query: 413 VWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472
WDEN+S GRYV+ENCKPL+ Y+ ++ EH QLFDL+ MLE++PA+R+TL EAL HPFF
Sbjct: 419 DWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 478
Query: 473 AGL--TPEERSFHTSRNPSR 490
A L P + + +SR+ SR
Sbjct: 479 ARLRAEPPNKLWDSSRDISR 498
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 514 bits (1324), Expect = e-146
Identities = 260/482 (53%), Positives = 329/482 (68%), Gaps = 26/482 (5%)
Query: 3 HCKRYRSPEPDPYLSYRW---KRRRSYSREHEGRLRYPSR--REPPPRRSRSRSHDRLPY 57
HC + S E + SYR ++RRS+S E R P +E +RS +
Sbjct: 8 HCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLN---- 63
Query: 58 QRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYR-------TRKHAHHC 110
+R YR+RR D YR DY RH R E G YR R
Sbjct: 64 ERDYRDRRYVDEYR---------NDYCEGYVPRHYHRDIESG-YRIHCSKSSVRSRRSSP 113
Query: 111 HKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKV 170
++R R CSS SRS+ ++ SRS+EDD+EGHL+C+ GD L+ RYEIV LGEG FGKV
Sbjct: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173
Query: 171 VECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHG 230
VEC+DH VA+KI++NVG+YREAAR EI VL+ + D + F CV M +WF+ HG
Sbjct: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233
Query: 231 HMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENIL 290
H+CI FELLG +T++F+KEN+F P+ + H+R MAYQ+C ++ FLH N+LTHTDLKPENIL
Sbjct: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENIL 293
Query: 291 FVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELG 350
FV S++ YN +E+++KNT I+V DFGSAT+D EHH+T+V+TRHYR PEVIL LG
Sbjct: 294 FVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALG 353
Query: 351 WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKG 410
W+QPCDVWSIGCIL EYY GFT+FQTH+++EHL MME+ILGPIP HMI +TRK+KYF+
Sbjct: 354 WSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHN 413
Query: 411 GLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHP 470
L WDE+SS GRYV+ CKPLK +ML EH +LFDL+RRMLE+DP QRITL EAL HP
Sbjct: 414 QLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHP 473
Query: 471 FF 472
FF
Sbjct: 474 FF 475
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 483 bits (1244), Expect = e-136
Identities = 248/484 (51%), Positives = 318/484 (65%), Gaps = 19/484 (3%)
Query: 1 MHHCKRYRSPEPDP----YLSYRW-----KRRRSYSREHEG-RLRYPSRREPPPRRSRSR 50
M H KR P+ D Y +R +R+RS+S E R +Y + SR
Sbjct: 43 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 102
Query: 51 SHDRLPYQ-RRY-RERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAH 108
S + Y RRY E R+ T CE P + + H +S R + K H
Sbjct: 103 SINEKDYHSRRYIDEYRNDYTQGCE---PGHRQRDHESRYQNHSSKSSGRSGRSSYKSKH 159
Query: 109 HCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFG 168
H S S S + ++ +RSVEDD+EGHL+C+ GD L RYEIV LGEG FG
Sbjct: 160 RIH----HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFG 215
Query: 169 KVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNF 228
KVVEC+DH G VA+KI++NV +Y EAAR EI VL+ + D + F CV M +WF
Sbjct: 216 KVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEH 275
Query: 229 HGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPEN 288
HGH+CI FELLG +T++F+KEN F P+ L H+R MAYQ+C ++ FLH N+LTHTDLKPEN
Sbjct: 276 HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPEN 335
Query: 289 ILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILE 348
ILFV S++ YN +E+++ N I+V DFGSAT+D EHH+T+V+TRHYR PEVIL
Sbjct: 336 ILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 395
Query: 349 LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFY 408
LGW+QPCDVWSIGCIL EYY GFT+F TH+++EHL MME+ILGP+P HMI +TRK+KYF+
Sbjct: 396 LGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFH 455
Query: 409 KGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALL 468
L WDE+SS GRYV CKPLK +ML +EH +LFDL+++MLE+DPA+RITL EAL
Sbjct: 456 HDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALK 515
Query: 469 HPFF 472
HPFF
Sbjct: 516 HPFF 519
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 483 bits (1244), Expect = e-136
Identities = 248/484 (51%), Positives = 318/484 (65%), Gaps = 19/484 (3%)
Query: 1 MHHCKRYRSPEPDP----YLSYRW-----KRRRSYSREHEG-RLRYPSRREPPPRRSRSR 50
M H KR P+ D Y +R +R+RS+S E R +Y + SR
Sbjct: 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR 60
Query: 51 SHDRLPYQ-RRY-RERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAH 108
S + Y RRY E R+ T CE P + + H +S R + K H
Sbjct: 61 SINEKDYHSRRYIDEYRNDYTQGCE---PGHRQRDHESRYQNHSSKSSGRSGRSSYKSKH 117
Query: 109 HCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFG 168
H S S S + ++ +RSVEDD+EGHL+C+ GD L RYEIV LGEG FG
Sbjct: 118 RIH----HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFG 173
Query: 169 KVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNF 228
KVVEC+DH G VA+KI++NV +Y EAAR EI VL+ + D + F CV M +WF
Sbjct: 174 KVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEH 233
Query: 229 HGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPEN 288
HGH+CI FELLG +T++F+KEN F P+ L H+R MAYQ+C ++ FLH N+LTHTDLKPEN
Sbjct: 234 HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPEN 293
Query: 289 ILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILE 348
ILFV S++ YN +E+++ N I+V DFGSAT+D EHH+T+V+TRHYR PEVIL
Sbjct: 294 ILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 353
Query: 349 LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFY 408
LGW+QPCDVWSIGCIL EYY GFT+F TH+++EHL MME+ILGP+P HMI +TRK+KYF+
Sbjct: 354 LGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFH 413
Query: 409 KGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALL 468
L WDE+SS GRYV CKPLK +ML +EH +LFDL+++MLE+DPA+RITL EAL
Sbjct: 414 HDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALK 473
Query: 469 HPFF 472
HPFF
Sbjct: 474 HPFF 477
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 204 bits (518), Expect = 2e-52
Identities = 120/355 (33%), Positives = 193/355 (54%), Gaps = 25/355 (7%)
Query: 130 KRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR 189
++ S++ DD+ G + + D + RYE++ +G+G+FG+V +CLDH + VALKIIR
Sbjct: 78 EKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDH-KNNELVALKIIR 136
Query: 190 NVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKE 249
N ++ + A +E+ +L+ +++KDK+N + V M D+F F H CI FELLG N +E +K
Sbjct: 137 NKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKN 196
Query: 250 NNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEK 309
NNFQ + L VR + L+ L ++ H DLKPENI+ LY + ++
Sbjct: 197 NNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIV--------LYQKGQA---- 244
Query: 310 SVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYR 369
S++V DFGS+ ++H+ T + +R YR PEVIL + D+WS+GCI E Y
Sbjct: 245 -----SVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYT 299
Query: 370 GFTLFQTHENREHLVMMEKILGPIPSHMIH-RTRKQKYFYKGGLVWDENSSDGRYVKENC 428
G+ LF E L + ++LG P+ I +R+Q +F G + ++ G+ +
Sbjct: 300 GYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDS 359
Query: 429 KPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF---AGLTPEER 480
K L + D +RR L ++P+ R+T +AL H + L P+ R
Sbjct: 360 KDLTMVL---KTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPR 411
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 192 bits (489), Expect = 4e-49
Identities = 116/356 (32%), Positives = 184/356 (51%), Gaps = 33/356 (9%)
Query: 138 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 197
DD +G V D + RYE++ +G+G+FG+VV+ DH + VALK++RN ++
Sbjct: 204 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDH-KVHQHVALKMVRNEKRFHRQ 262
Query: 198 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 257
A EI +L+ ++++DK+N + M + F F H+C+ FELL N +E +K+N FQ + L
Sbjct: 263 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 322
Query: 258 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 317
P VR A+ + L LH+N++ H DLKPENIL K + I+
Sbjct: 323 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILL-----------------KQQGRSGIK 365
Query: 318 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 377
V DFGS+ ++H+ T + +R YR PEVIL + P D+WS+GCIL E G+ L
Sbjct: 366 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 425
Query: 378 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKG----GLVWDENSSDGRYVKENCK---- 429
+ + L M ++LG ++ +++ K F SDG V +
Sbjct: 426 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRG 485
Query: 430 ----PLKSYMLQDSLEHVQ---LFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE 478
P +S ++L+ D +++ LE+DPA R+T +AL HP+ P+
Sbjct: 486 KLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPK 541
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 192 bits (489), Expect = 4e-49
Identities = 116/356 (32%), Positives = 184/356 (51%), Gaps = 33/356 (9%)
Query: 138 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 197
DD +G V D + RYE++ +G+G+FG+VV+ DH + VALK++RN ++
Sbjct: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDH-KVHQHVALKMVRNEKRFHRQ 189
Query: 198 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 257
A EI +L+ ++++DK+N + M + F F H+C+ FELL N +E +K+N FQ + L
Sbjct: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249
Query: 258 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 317
P VR A+ + L LH+N++ H DLKPENIL K + I+
Sbjct: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILL-----------------KQQGRSGIK 292
Query: 318 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 377
V DFGS+ ++H+ T + +R YR PEVIL + P D+WS+GCIL E G+ L
Sbjct: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352
Query: 378 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKG----GLVWDENSSDGRYVKENCK---- 429
+ + L M ++LG ++ +++ K F SDG V +
Sbjct: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412
Query: 430 ----PLKSYMLQDSLEHVQ---LFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE 478
P +S ++L+ D +++ LE+DPA R+T +AL HP+ P+
Sbjct: 413 KLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPK 468
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 187 bits (475), Expect = 2e-47
Identities = 114/355 (32%), Positives = 183/355 (51%), Gaps = 33/355 (9%)
Query: 138 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 197
DD +G + D L RYE++ +G+G+FG+V DH + + VALK++RN ++
Sbjct: 171 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHRQ 229
Query: 198 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 257
A EI +L+ +K++DK + M + F F H+C+AFELL + +E +K+N FQ + +
Sbjct: 230 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 289
Query: 258 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 317
VR A + +L LH+N++ H DLKPENIL K +S +
Sbjct: 290 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-----------------KHHGRSSTK 332
Query: 318 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 377
V DFGS+ F+++ T + +R YR PE+IL ++ P D+WS GCIL E G LF
Sbjct: 333 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 392
Query: 378 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENS----SDGRYV--------- 424
+ + L M ++LG P ++ ++++ KYF + S +DGR V
Sbjct: 393 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 452
Query: 425 -KENCKPLKSY-MLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTP 477
K K + + + ++R L +DP+ R+T A+AL HP+ + P
Sbjct: 453 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 507
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 187 bits (475), Expect = 2e-47
Identities = 114/355 (32%), Positives = 183/355 (51%), Gaps = 33/355 (9%)
Query: 138 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 197
DD +G + D L RYE++ +G+G+FG+V DH + + VALK++RN ++
Sbjct: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHRQ 249
Query: 198 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 257
A EI +L+ +K++DK + M + F F H+C+AFELL + +E +K+N FQ + +
Sbjct: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
Query: 258 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 317
VR A + +L LH+N++ H DLKPENIL K +S +
Sbjct: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-----------------KHHGRSSTK 352
Query: 318 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 377
V DFGS+ F+++ T + +R YR PE+IL ++ P D+WS GCIL E G LF
Sbjct: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
Query: 378 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENS----SDGRYV--------- 424
+ + L M ++LG P ++ ++++ KYF + S +DGR V
Sbjct: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
Query: 425 -KENCKPLKSY-MLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTP 477
K K + + + ++R L +DP+ R+T A+AL HP+ + P
Sbjct: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 182 bits (462), Expect = 6e-46
Identities = 123/378 (32%), Positives = 193/378 (51%), Gaps = 35/378 (9%)
Query: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157
+T KH + + KRR + S +++ K + +DD ++V R G+ ERYE
Sbjct: 54 KTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYE 112
Query: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217
I +G+G+FG+VV+ DH + + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 113 IDSLIGKGSFGQVVKAYDH-QTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKY 171
Query: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277
V + F F H+C+ FELL N ++ L+ +F+ L R +A QLC AL FL
Sbjct: 172 YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATP 231
Query: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 232 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 274
Query: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395
+R YR PEV+L + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 275 QSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPA 334
Query: 396 HMIHRTRK-QKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLE 454
M+ + K +KYF E G + K L+ +Q DL+ RMLE
Sbjct: 335 AMLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQ-EDLVLRMLE 385
Query: 455 FDPAQRITLAEALLHPFF 472
++PA RI+ AL H FF
Sbjct: 386 YEPAARISPLGALQHGFF 403
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 180 bits (457), Expect = 2e-45
Identities = 122/378 (32%), Positives = 191/378 (50%), Gaps = 47/378 (12%)
Query: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157
+T KH + + KRR + S +++ K + +DD ++V R G+ ERYE
Sbjct: 54 KTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYE 112
Query: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217
I +G+G+FG+VV+ DH + + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 113 IDSLIGKGSFGQVVKAYDH-QTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKY 171
Query: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277
V + F F H+C+ FELL N ++ L+ +F+ L R +A QLC AL FL
Sbjct: 172 YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATP 231
Query: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 232 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 274
Query: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395
+R YR PEV+L + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 275 QSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPA 334
Query: 396 HMIHRTRK-QKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLE 454
M+ + K +KYF E G + K L+ DL+ RMLE
Sbjct: 335 AMLDQAPKARKYF--------ERLPGGGWTLRRTKELRK-------------DLVLRMLE 373
Query: 455 FDPAQRITLAEALLHPFF 472
++PA RI+ AL H FF
Sbjct: 374 YEPAARISPLGALQHGFF 391
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 177 bits (450), Expect = 1e-44
Identities = 128/460 (27%), Positives = 218/460 (47%), Gaps = 63/460 (13%)
Query: 54 RLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGP------------Y 101
++P+ +Y +RR + + + S+ + P ++ R R P
Sbjct: 33 QMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQRRMPQTFRDPATAPLRKLSVDLI 92
Query: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157
+T KH + + KRR + S ++ K + +DD ++V W+ +RYE
Sbjct: 93 KTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYE 151
Query: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217
I +G+G+FG+VV+ D + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 152 IDSLIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY 210
Query: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277
V + F F H+C+ FE+L N ++ L+ NF+ L R A Q+C AL FL
Sbjct: 211 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATP 270
Query: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 271 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 313
Query: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395
+R YR PEV+L + + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 314 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 373
Query: 396 HMIHRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL------------ 440
H++ + K + F++ W+ + + DG K KP + L + L
Sbjct: 374 HILDQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRA 430
Query: 441 --------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472
++++ DL+ RML++DP RI AL H FF
Sbjct: 431 GESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 470
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 176 bits (447), Expect = 3e-44
Identities = 127/405 (31%), Positives = 200/405 (49%), Gaps = 61/405 (15%)
Query: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157
+T KH + + KRR + S +++ K + +DD ++V R G+ ERYE
Sbjct: 54 KTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYE 112
Query: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217
I +G+G+FG+VV+ DH + + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 113 IDSLIGKGSFGQVVKAYDH-QTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKY 171
Query: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277
V + F F H+C+ FELL N ++ L+ +F+ L R +A QLC AL FL
Sbjct: 172 YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATP 231
Query: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 232 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 274
Query: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395
+R YR PEV+L + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 275 QSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPA 334
Query: 396 HMIHRTRK-QKYFYKGGLVWDENSSDGRYVKENCKPL-KSYM------LQDSL------- 440
M+ + K +KYF E G + K L K Y LQ+ L
Sbjct: 335 AMLDQAPKARKYF--------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGP 386
Query: 441 -------------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472
++++ DL+ RMLE++PA RI+ AL H FF
Sbjct: 387 GGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF 431
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 171 bits (434), Expect = 1e-42
Identities = 119/400 (29%), Positives = 197/400 (49%), Gaps = 51/400 (12%)
Query: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157
+T KH + + KRR + S ++ K + +DD ++V W+ +RYE
Sbjct: 102 KTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYE 160
Query: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217
I +G+G+FG+VV+ D + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 161 IDSLIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY 219
Query: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277
V + F F H+C+ FE+L N ++ L+ NF+ L R A Q+C AL FL
Sbjct: 220 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATP 279
Query: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 280 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 322
Query: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395
+R YR PEV+L + + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 323 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 382
Query: 396 HMIHRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL------------ 440
H++ + K + F++ W+ + + DG K KP + L + L
Sbjct: 383 HILDQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRA 439
Query: 441 --------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472
++++ DL+ RML++DP RI AL H FF
Sbjct: 440 GESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 171 bits (434), Expect = 1e-42
Identities = 119/400 (29%), Positives = 197/400 (49%), Gaps = 51/400 (12%)
Query: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157
+T KH + + KRR + S ++ K + +DD ++V W+ +RYE
Sbjct: 102 KTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYE 160
Query: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217
I +G+G+FG+VV+ D + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 161 IDSLIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY 219
Query: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277
V + F F H+C+ FE+L N ++ L+ NF+ L R A Q+C AL FL
Sbjct: 220 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATP 279
Query: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 280 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 322
Query: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395
+R YR PEV+L + + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 323 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 382
Query: 396 HMIHRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL------------ 440
H++ + K + F++ W+ + + DG K KP + L + L
Sbjct: 383 HILDQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRA 439
Query: 441 --------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472
++++ DL+ RML++DP RI AL H FF
Sbjct: 440 GESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 171 bits (434), Expect = 1e-42
Identities = 119/400 (29%), Positives = 197/400 (49%), Gaps = 51/400 (12%)
Query: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157
+T KH + + KRR + S ++ K + +DD ++V W+ +RYE
Sbjct: 102 KTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYE 160
Query: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217
I +G+G+FG+VV+ D + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 161 IDSLIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY 219
Query: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277
V + F F H+C+ FE+L N ++ L+ NF+ L R A Q+C AL FL
Sbjct: 220 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATP 279
Query: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 280 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 322
Query: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395
+R YR PEV+L + + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 323 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 382
Query: 396 HMIHRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL------------ 440
H++ + K + F++ W+ + + DG K KP + L + L
Sbjct: 383 HILDQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRA 439
Query: 441 --------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472
++++ DL+ RML++DP RI AL H FF
Sbjct: 440 GESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 171 bits (434), Expect = 1e-42
Identities = 119/400 (29%), Positives = 197/400 (49%), Gaps = 51/400 (12%)
Query: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157
+T KH + + KRR + S ++ K + +DD ++V W+ +RYE
Sbjct: 102 KTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYE 160
Query: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217
I +G+G+FG+VV+ D + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 161 IDSLIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY 219
Query: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277
V + F F H+C+ FE+L N ++ L+ NF+ L R A Q+C AL FL
Sbjct: 220 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATP 279
Query: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 280 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 322
Query: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395
+R YR PEV+L + + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 323 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 382
Query: 396 HMIHRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL------------ 440
H++ + K + F++ W+ + + DG K KP + L + L
Sbjct: 383 HILDQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRA 439
Query: 441 --------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472
++++ DL+ RML++DP RI AL H FF
Sbjct: 440 GESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 155 bits (391), Expect = 1e-37
Identities = 110/351 (31%), Positives = 170/351 (48%), Gaps = 36/351 (10%)
Query: 139 DKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAA 198
D EG+ IG+ L +RY + G G+G F VV D+AR +VA+KIIRN ++
Sbjct: 670 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729
Query: 199 RLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKE-NNFQPYPL 257
E+ LKK+ + D ++KF C+ + F H+C+ FE L N E LK+ +
Sbjct: 730 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789
Query: 258 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 317
VR + QL AL+ L + H D+KP+NI L NE K T ++
Sbjct: 790 KAVRSYSQQLFLALKLLKRCNILHADIKPDNI---------LVNESK---------TILK 831
Query: 318 VADFGSATFDHEHH-TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQT 376
+ DFGSA+ ++ T + +R YR PE+I+ + D+WS+GC L+E Y G LF
Sbjct: 832 LCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPG 891
Query: 377 HENREHLVMMEKILGPIPSHMIHR--TRKQKYFYKGGLVWDE----NSSDGRYVKENCKP 430
N L + + G +P+ MI + + Q + ++ E + V P
Sbjct: 892 KTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINP 951
Query: 431 LKSYML---------QDSLEHV-QLFDLMRRMLEFDPAQRITLAEALLHPF 471
K + +D + V QL DL+ ++L DPA+RI++ +AL H F
Sbjct: 952 TKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002
Score = 43.9 bits (102), Expect = 3e-04
Identities = 49/151 (32%), Positives = 65/151 (43%), Gaps = 18/151 (11%)
Query: 8 RSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRL---PYQRRY--- 61
RS P P R R + + + PSR P RR++SRS +R P +RR
Sbjct: 353 RSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSP 412
Query: 62 RERRDSDTYRCEERSPSFGE-DYYGPSRSRHRR--RSRERGPY--------RTRKHAHHC 110
R R D ERS + + P+R R R R R R P R+R
Sbjct: 413 RTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRD 472
Query: 111 HKRRTRSCSSASSRSQQSSKRSSRS-VEDDK 140
RR+RS SRS+ +R SRS V++DK
Sbjct: 473 RGRRSRSRLRRRSRSRGGRRRRSRSKVKEDK 503
Score = 42.4 bits (98), Expect = 0.001
Identities = 45/144 (31%), Positives = 57/144 (39%), Gaps = 15/144 (10%)
Query: 5 KRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRER 64
+R SP P +R RS R RR P R RSRS P +R R
Sbjct: 407 RRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRS----PLRRSRSPR 462
Query: 65 RDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSR 124
R S + R +R SRSR RRRSR RG R R + + S S
Sbjct: 463 RRSRSPRRRDRGRR--------SRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKV 514
Query: 125 SQQSSKRSSR---SVEDDKEGHLV 145
Q+SS + VE++ E L+
Sbjct: 515 EQESSSDDNLEDFDVEEEDEEALI 538
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 151 bits (381), Expect = 1e-36
Identities = 108/385 (28%), Positives = 186/385 (48%), Gaps = 55/385 (14%)
Query: 120 SASSRSQQSSKRSSRSVEDDKE---GHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDH 176
+ ++ S +SK S + E D + ++C + YE++ LG GTFG+VV+C
Sbjct: 164 ATATTSTATSKNSGSNSEGDYQLVQHEVLCS----MTNTYEVLEFLGRGTFGQVVKCWK- 218
Query: 177 ARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIA 235
RG ++ VA+KI++N Y ++E+++L ++ + ++ + V + F H C+
Sbjct: 219 -RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLV 276
Query: 236 FELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSE 295
FE+L +N ++FLK+N F P PL ++R + Q+ AL L L H DLKPENI+ V
Sbjct: 277 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV--- 333
Query: 296 FETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEHHTTIVATRHYRPPEVILELGWAQP 354
+ S + ++V DFGSA+ +T + +R+YR PE+IL L + +
Sbjct: 334 ------------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEA 381
Query: 355 CDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGL-- 412
D+WS+GC++ E + G+ L+ + + + + G +++ K F+
Sbjct: 382 IDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDS 441
Query: 413 ---VW------DENSSDGRYVKENCKPL-----------------KSYMLQDSLEHVQLF 446
+W D + G KE K + S ML + + +
Sbjct: 442 PYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFI 501
Query: 447 DLMRRMLEFDPAQRITLAEALLHPF 471
DL+++ML D +RIT E L HPF
Sbjct: 502 DLLKKMLTIDADKRITPIETLNHPF 526
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 151 bits (381), Expect = 1e-36
Identities = 108/385 (28%), Positives = 186/385 (48%), Gaps = 55/385 (14%)
Query: 120 SASSRSQQSSKRSSRSVEDDKE---GHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDH 176
+ ++ S +SK S + E D + ++C + YE++ LG GTFG+VV+C
Sbjct: 164 ATATTSTATSKNSGSNSEGDYQLVQHEVLCS----MTNTYEVLEFLGRGTFGQVVKCWK- 218
Query: 177 ARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIA 235
RG ++ VA+KI++N Y ++E+++L ++ + ++ + V + F H C+
Sbjct: 219 -RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLV 276
Query: 236 FELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSE 295
FE+L +N ++FLK+N F P PL ++R + Q+ AL L L H DLKPENI+ V
Sbjct: 277 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV--- 333
Query: 296 FETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEHHTTIVATRHYRPPEVILELGWAQP 354
+ S + ++V DFGSA+ +T + +R+YR PE+IL L + +
Sbjct: 334 ------------DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEA 381
Query: 355 CDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGL-- 412
D+WS+GC++ E + G+ L+ + + + + G +++ K F+
Sbjct: 382 IDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDS 441
Query: 413 ---VW------DENSSDGRYVKENCKPL-----------------KSYMLQDSLEHVQLF 446
+W D + G KE K + S ML + + +
Sbjct: 442 PYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFI 501
Query: 447 DLMRRMLEFDPAQRITLAEALLHPF 471
DL+++ML D +RIT E L HPF
Sbjct: 502 DLLKKMLTIDADKRITPIETLNHPF 526
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 145 bits (366), Expect = 8e-35
Identities = 100/384 (26%), Positives = 184/384 (47%), Gaps = 53/384 (13%)
Query: 120 SASSRSQQSSKRSSRSVEDDKE---GHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDH 176
+A++ + ++K SS S E D + ++C + YE++ LG GTFG+V +C
Sbjct: 155 AAATTTTVTTKSSSSSGEGDYQLVQHEILCS----MTNSYEVLEFLGRGTFGQVAKCWKR 210
Query: 177 ARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAF 236
+ K VA+KI++N Y ++E+++L ++ ++ + ++ V + F H C+ F
Sbjct: 211 ST-KEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVF 268
Query: 237 ELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEF 296
E+L +N ++FLK+N F P PL ++R + Q+ AL L L H DLKPENI+ V+
Sbjct: 269 EMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVR 328
Query: 297 ETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEHHTTIVATRHYRPPEVILELGWAQPC 355
+ ++V DFGSA+ +T + +R+YR PE+IL L + +
Sbjct: 329 QPY---------------RVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAI 373
Query: 356 DVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYK-----G 410
D+WS+GC++ E + G+ L+ + + + + G +++ K F+ G
Sbjct: 374 DMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLG 433
Query: 411 GLVWDENSSDGRYVKENCKPLKSY-----------------------MLQDSLEHVQLFD 447
+W + + ++ K ++ ML + + + D
Sbjct: 434 YPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYID 493
Query: 448 LMRRMLEFDPAQRITLAEALLHPF 471
L+++ML D +RIT + L H F
Sbjct: 494 LLKKMLTIDADKRITPLKTLNHQF 517
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 145 bits (366), Expect = 8e-35
Identities = 100/384 (26%), Positives = 184/384 (47%), Gaps = 53/384 (13%)
Query: 120 SASSRSQQSSKRSSRSVEDDKE---GHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDH 176
+A++ + ++K SS S E D + ++C + YE++ LG GTFG+V +C
Sbjct: 155 AAATTTTVTTKSSSSSGEGDYQLVQHEILCS----MTNSYEVLEFLGRGTFGQVAKCWKR 210
Query: 177 ARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAF 236
+ K VA+KI++N Y ++E+++L ++ ++ + ++ V + F H C+ F
Sbjct: 211 ST-KEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVF 268
Query: 237 ELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEF 296
E+L +N ++FLK+N F P PL ++R + Q+ AL L L H DLKPENI+ V+
Sbjct: 269 EMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVR 328
Query: 297 ETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEHHTTIVATRHYRPPEVILELGWAQPC 355
+ ++V DFGSA+ +T + +R+YR PE+IL L + +
Sbjct: 329 QPY---------------RVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAI 373
Query: 356 DVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYK-----G 410
D+WS+GC++ E + G+ L+ + + + + G +++ K F+ G
Sbjct: 374 DMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLG 433
Query: 411 GLVWDENSSDGRYVKENCKPLKSY-----------------------MLQDSLEHVQLFD 447
+W + + ++ K ++ ML + + + D
Sbjct: 434 YPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYID 493
Query: 448 LMRRMLEFDPAQRITLAEALLHPF 471
L+++ML D +RIT + L H F
Sbjct: 494 LLKKMLTIDADKRITPLKTLNHQF 517
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 142 bits (359), Expect = 5e-34
Identities = 100/352 (28%), Positives = 174/352 (49%), Gaps = 52/352 (14%)
Query: 152 LQERYEIVGNLGEGTFGKVVECLDHARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKE 210
++ YE++ LG GTFG+VV+C RG ++ VA+KI++N Y ++E+++L ++
Sbjct: 193 MKNTYEVLDFLGRGTFGQVVKCWK--RGTNEIVAIKILKNHPSYARQGQIEVSILARLST 250
Query: 211 KDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHA 270
++ + ++ V + F H C+ FE+L +N ++FLK+N F P PL +R + Q+ A
Sbjct: 251 ENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATA 309
Query: 271 LRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEH 330
L+ L L H DLKPENI+ V+ + ++V DFGSA+ H
Sbjct: 310 LKKLKSLGLIHADLKPENIMLVDPVRQPY---------------RVKVIDFGSAS--HVS 352
Query: 331 HT---TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 387
T T + +R+YR PE+IL L + + D+WS+GC++ E + G+ L+ + + +
Sbjct: 353 KTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYIS 412
Query: 388 KILGPIPSHMIH-RTRKQKYFYKG----------GLVWDENSSDGRYVKENCKPL----- 431
+ G +++ T+ ++F K + + + G KE K +
Sbjct: 413 QTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLD 472
Query: 432 ------------KSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPF 471
S +L + + + L+++ML D RIT AE L HPF
Sbjct: 473 DVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 142 bits (359), Expect = 5e-34
Identities = 100/352 (28%), Positives = 174/352 (49%), Gaps = 52/352 (14%)
Query: 152 LQERYEIVGNLGEGTFGKVVECLDHARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKE 210
++ YE++ LG GTFG+VV+C RG ++ VA+KI++N Y ++E+++L ++
Sbjct: 193 MKNTYEVLDFLGRGTFGQVVKCWK--RGTNEIVAIKILKNHPSYARQGQIEVSILARLST 250
Query: 211 KDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHA 270
++ + ++ V + F H C+ FE+L +N ++FLK+N F P PL +R + Q+ A
Sbjct: 251 ENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATA 309
Query: 271 LRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEH 330
L+ L L H DLKPENI+ V+ + ++V DFGSA+ H
Sbjct: 310 LKKLKSLGLIHADLKPENIMLVDPVRQPY---------------RVKVIDFGSAS--HVS 352
Query: 331 HT---TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 387
T T + +R+YR PE+IL L + + D+WS+GC++ E + G+ L+ + + +
Sbjct: 353 KTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYIS 412
Query: 388 KILGPIPSHMIH-RTRKQKYFYKG----------GLVWDENSSDGRYVKENCKPL----- 431
+ G +++ T+ ++F K + + + G KE K +
Sbjct: 413 QTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLD 472
Query: 432 ------------KSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPF 471
S +L + + + L+++ML D RIT AE L HPF
Sbjct: 473 DVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 141 bits (356), Expect = 1e-33
Identities = 103/353 (29%), Positives = 170/353 (48%), Gaps = 54/353 (15%)
Query: 156 YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKEN 215
Y+I+ LG+GTFG+V + + G+ VA+KI++N + E+ +L ++ D E
Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGE-MVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEE 69
Query: 216 KFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLH 275
+ + ++F+ + FELL +N FEF KENNF P P H+R + Q+ AL L
Sbjct: 70 AHV-IRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK 128
Query: 276 ENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHH---T 332
E + H DLKPENI+ V + C + ++V DFGSA+ E
Sbjct: 129 ELAIIHADLKPENIMLV---------DQTRCPFR------VKVIDFGSASIFSEVRYVKE 173
Query: 333 TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP 392
+ +R YR PE++L L + + DVWS+GC++ E + G+ L+ + + + + + G
Sbjct: 174 PYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGL 233
Query: 393 IPSHMIHRTRKQKYFYK------GGLVWDENSSDGRYVKENCKPL--KSYMLQ--DSLEH 442
H++H K +F+K W SS + +PL + YML+ D +E
Sbjct: 234 PKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIET 293
Query: 443 V------------------------QLFDLMRRMLEFDPAQRITLAEALLHPF 471
V + +L++RML ++ +RI+ + AL HPF
Sbjct: 294 VNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 132 bits (333), Expect = 5e-31
Identities = 94/327 (28%), Positives = 153/327 (46%), Gaps = 44/327 (13%)
Query: 152 LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEK 211
+ ++EI+G +GEG +G V++C H VA+K ++ + E + LK ++
Sbjct: 9 VMNKFEILGVVGEGAYGVVLKCR-HKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 67
Query: 212 DKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHAL 271
+EN V + + F G + + FE + KN E L+E P V+ YQL A+
Sbjct: 68 KQEN---IVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAI 123
Query: 272 RFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF----D 327
+ H+N + H D+KPEN+L + N +++ DFG A +
Sbjct: 124 HWCHKNDIVHRDIKPENLLISH-------------------NDVLKLCDFGFARNLSEGN 164
Query: 328 HEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 387
+ ++T VATR YR PE++L + + D+WS+GCIL E G LF + L ++
Sbjct: 165 NANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQ 224
Query: 388 KILGPIPSHMIHRTRKQKYFY--KGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQL 445
K+LGP+PS + F+ + V S + RY+ + + L
Sbjct: 225 KVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYL--------------GILNSVL 270
Query: 446 FDLMRRMLEFDPAQRITLAEALLHPFF 472
DLM+ +L+ DPA R + L HP F
Sbjct: 271 LDLMKNLLKLDPADRYLTEQCLNHPTF 297
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 132 bits (333), Expect = 5e-31
Identities = 94/327 (28%), Positives = 153/327 (46%), Gaps = 44/327 (13%)
Query: 152 LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEK 211
+ ++EI+G +GEG +G V++C H VA+K ++ + E + LK ++
Sbjct: 9 VMNKFEILGVVGEGAYGVVLKCR-HKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 67
Query: 212 DKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHAL 271
+EN V + + F G + + FE + KN E L+E P V+ YQL A+
Sbjct: 68 KQEN---IVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAI 123
Query: 272 RFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF----D 327
+ H+N + H D+KPEN+L + N +++ DFG A +
Sbjct: 124 HWCHKNDIVHRDIKPENLLISH-------------------NDVLKLCDFGFARNLSEGN 164
Query: 328 HEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 387
+ ++T VATR YR PE++L + + D+WS+GCIL E G LF + L ++
Sbjct: 165 NANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQ 224
Query: 388 KILGPIPSHMIHRTRKQKYFY--KGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQL 445
K+LGP+PS + F+ + V S + RY+ + + L
Sbjct: 225 KVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYL--------------GILNSVL 270
Query: 446 FDLMRRMLEFDPAQRITLAEALLHPFF 472
DLM+ +L+ DPA R + L HP F
Sbjct: 271 LDLMKNLLKLDPADRYLTEQCLNHPTF 297
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 118 bits (295), Expect = 1e-26
Identities = 93/323 (28%), Positives = 154/323 (47%), Gaps = 46/323 (14%)
Query: 155 RYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKE 214
RY + LG+GT+G V+ G+ K+ R + E L +++K K
Sbjct: 3 RYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNL-----REVKSLKKL 57
Query: 215 NKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFL 274
N V + + + H+ FE + +N ++ +KE N + +P +R++ YQ+ L F+
Sbjct: 58 NHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERN-KLFPESAIRNIMYQILQGLAFI 116
Query: 275 HENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA--TFDHEHHT 332
H++ H DLKPEN+L + E +++ADFG A +T
Sbjct: 117 HKHGFFHRDLKPENLLCMGPEL-------------------VKIADFGLAREIRSKPPYT 157
Query: 333 TIVATRHYRPPEVIL-ELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILG 391
V+TR YR PEV+L ++ P DVW++GCI+ E Y LF + + + ++LG
Sbjct: 158 DYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLG 217
Query: 392 PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKP--LKSYMLQDSLEHVQLFDLM 449
T K+ + +G + SS + C P LK+ + S E VQ L+
Sbjct: 218 ---------TPKKTDWPEG----YQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQ---LL 261
Query: 450 RRMLEFDPAQRITLAEALLHPFF 472
R ML++DP +R T ++AL +P+F
Sbjct: 262 RDMLQWDPKKRPTASQALRYPYF 284
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,276,403
Number of Sequences: 37866
Number of extensions: 1019303
Number of successful extensions: 7749
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 544
Number of HSP's successfully gapped in prelim test: 410
Number of HSP's that attempted gapping in prelim test: 3515
Number of HSP's gapped (non-prelim): 2271
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.