Search of human proteins with 15147337

Search of human proteins with 15147337

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15147337 ubiquitin protein ligase E3 component n-recognin 5
[Homo sapiens]
         (2799 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [...  5572   0.0  
gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3 c...  5475   0.0  
gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3 c...  4460   0.0  
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...   123   3e-27
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]      115   8e-25
gi|87116668 hypothetical protein LOC9870 [Homo sapiens]               110   3e-23
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...   104   1e-21
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...   104   1e-21
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]     103   3e-21
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]     103   3e-21
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]     103   3e-21
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...   102   4e-21
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote...   101   1e-20
gi|222352183 neural precursor cell expressed, developmentally do...   100   2e-20
gi|21361472 neural precursor cell expressed, developmentally dow...   100   2e-20
gi|222352094 neural precursor cell expressed, developmentally do...   100   2e-20
gi|222352092 neural precursor cell expressed, developmentally do...   100   2e-20
gi|222352090 neural precursor cell expressed, developmentally do...   100   2e-20
gi|222352088 neural precursor cell expressed, developmentally do...   100   2e-20
gi|222352086 neural precursor cell expressed, developmentally do...   100   2e-20
gi|222352084 neural precursor cell expressed, developmentally do...   100   2e-20
gi|222352082 neural precursor cell expressed, developmentally do...   100   2e-20
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...    96   4e-19
gi|114520609 neural precursor cell expressed, developmentally do...    96   4e-19
gi|114520607 neural precursor cell expressed, developmentally do...    96   4e-19
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]       94   1e-18
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]               89   5e-17
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]    87   3e-16
gi|126032348 hect domain and RLD 2 [Homo sapiens]                      83   4e-15
gi|157738609 HECT domain containing 3 [Homo sapiens]                   81   1e-14

>gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [Homo
            sapiens]
          Length = 2799

 Score = 5572 bits (14454), Expect = 0.0
 Identities = 2799/2799 (100%), Positives = 2799/2799 (100%)

Query: 1    MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF 60
            MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
Sbjct: 1    MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF 60

Query: 61   LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL 120
            LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
Sbjct: 61   LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL 120

Query: 121  GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI 180
            GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
Sbjct: 121  GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI 180

Query: 181  PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE 240
            PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
Sbjct: 181  PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE 240

Query: 241  SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP 300
            SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
Sbjct: 241  SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP 300

Query: 301  LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL 360
            LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL
Sbjct: 301  LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL 360

Query: 361  QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT 420
            QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT
Sbjct: 361  QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT 420

Query: 421  NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA 480
            NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA
Sbjct: 421  NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA 480

Query: 481  LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP 540
            LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP
Sbjct: 481  LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP 540

Query: 541  LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ 600
            LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ
Sbjct: 541  LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ 600

Query: 601  EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE 660
            EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE
Sbjct: 601  EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE 660

Query: 661  DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK 720
            DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK
Sbjct: 661  DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK 720

Query: 721  TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ 780
            TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ
Sbjct: 721  TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ 780

Query: 781  ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP 840
            ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP
Sbjct: 781  ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP 840

Query: 841  ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV 900
            ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV
Sbjct: 841  ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV 900

Query: 901  LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE 960
            LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE
Sbjct: 901  LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE 960

Query: 961  AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP 1020
            AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP
Sbjct: 961  AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP 1020

Query: 1021 IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD 1080
            IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD
Sbjct: 1021 IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD 1080

Query: 1081 RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA 1140
            RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA
Sbjct: 1081 RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA 1140

Query: 1141 KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG 1200
            KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG
Sbjct: 1141 KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG 1200

Query: 1201 LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT 1260
            LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT
Sbjct: 1201 LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT 1260

Query: 1261 ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE 1320
            ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
Sbjct: 1261 ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE 1320

Query: 1321 PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL 1380
            PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL
Sbjct: 1321 PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL 1380

Query: 1381 DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS 1440
            DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS
Sbjct: 1381 DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS 1440

Query: 1441 VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA 1500
            VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA
Sbjct: 1441 VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA 1500

Query: 1501 STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE 1560
            STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE
Sbjct: 1501 STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE 1560

Query: 1561 QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA 1620
            QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA
Sbjct: 1561 QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA 1620

Query: 1621 ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ 1680
            ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ
Sbjct: 1621 ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ 1680

Query: 1681 SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS 1740
            SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS
Sbjct: 1681 SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS 1740

Query: 1741 SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG 1800
            SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG
Sbjct: 1741 SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG 1800

Query: 1801 LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA 1860
            LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA
Sbjct: 1801 LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA 1860

Query: 1861 SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY 1920
            SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY
Sbjct: 1861 SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY 1920

Query: 1921 ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL 1980
            ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL
Sbjct: 1921 ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL 1980

Query: 1981 LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF 2040
            LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF
Sbjct: 1981 LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF 2040

Query: 2041 EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT 2100
            EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT
Sbjct: 2041 EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT 2100

Query: 2101 KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE 2160
            KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE
Sbjct: 2101 KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE 2160

Query: 2161 SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV 2220
            SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV
Sbjct: 2161 SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV 2220

Query: 2221 KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT 2280
            KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT
Sbjct: 2221 KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT 2280

Query: 2281 FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER 2340
            FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER
Sbjct: 2281 FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER 2340

Query: 2341 EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER 2400
            EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER
Sbjct: 2341 EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER 2400

Query: 2401 LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS 2460
            LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS
Sbjct: 2401 LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS 2460

Query: 2461 ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK 2520
            ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK
Sbjct: 2461 ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK 2520

Query: 2521 NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR 2580
            NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR
Sbjct: 2521 NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR 2580

Query: 2581 QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE 2640
            QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE
Sbjct: 2581 QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE 2640

Query: 2641 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES 2700
            HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES
Sbjct: 2641 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES 2700

Query: 2701 GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ 2760
            GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ
Sbjct: 2701 GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ 2760

Query: 2761 HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2799
            HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV
Sbjct: 2761 HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2799


>gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3
            component n-recognin 5 isoform 1 [Homo sapiens]
          Length = 2796

 Score = 5475 bits (14204), Expect = 0.0
 Identities = 2759/2799 (98%), Positives = 2770/2799 (98%), Gaps = 3/2799 (0%)

Query: 1    MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF 60
            MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNV +QATIKQCVVGPNHAAF
Sbjct: 1    MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVFQQATIKQCVVGPNHAAF 60

Query: 61   LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL 120
            LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
Sbjct: 61   LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL 120

Query: 121  GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI 180
            GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
Sbjct: 121  GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI 180

Query: 181  PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE 240
            PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
Sbjct: 181  PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE 240

Query: 241  SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP 300
            SYL GEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
Sbjct: 241  SYLAGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP 300

Query: 301  LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL 360
            LERDSELLRERESVLRLRERRWLDGASFDNERGST +     LDKKNTPVQSPVSLGEDL
Sbjct: 301  LERDSELLRERESVLRLRERRWLDGASFDNERGSTKQGRRAKLDKKNTPVQSPVSLGEDL 360

Query: 361  QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT 420
            QWWPDKDGTKFIC+ ALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT
Sbjct: 361  QWWPDKDGTKFICM-ALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT 419

Query: 421  NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA 480
            NEKIVLLSANSIRATVATE NKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA
Sbjct: 420  NEKIVLLSANSIRATVATEKNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA 479

Query: 481  LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP 540
            LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP
Sbjct: 480  LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP 539

Query: 541  LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ 600
            LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ
Sbjct: 540  LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ 599

Query: 601  EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE 660
            EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE
Sbjct: 600  EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE 659

Query: 661  DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK 720
            DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK
Sbjct: 660  DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK 719

Query: 721  TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ 780
            TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ
Sbjct: 720  TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ 779

Query: 781  ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP 840
            ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP
Sbjct: 780  ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP 839

Query: 841  ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV 900
            ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQ   
Sbjct: 840  ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRF- 898

Query: 901  LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE 960
            LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE
Sbjct: 899  LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE 958

Query: 961  AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP 1020
            AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP
Sbjct: 959  AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP 1018

Query: 1021 IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD 1080
            IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD
Sbjct: 1019 IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD 1078

Query: 1081 RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA 1140
            RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA
Sbjct: 1079 RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA 1138

Query: 1141 KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG 1200
            KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG
Sbjct: 1139 KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG 1198

Query: 1201 LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT 1260
            LLESLCCCTECA VCHKGHD KLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT
Sbjct: 1199 LLESLCCCTECAGVCHKGHDWKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT 1258

Query: 1261 ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE 1320
            ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
Sbjct: 1259 ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE 1318

Query: 1321 PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL 1380
            PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL
Sbjct: 1319 PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL 1378

Query: 1381 DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS 1440
            DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS
Sbjct: 1379 DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS 1438

Query: 1441 VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA 1500
            VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA
Sbjct: 1439 VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA 1498

Query: 1501 STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE 1560
            STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE
Sbjct: 1499 STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE 1558

Query: 1561 QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA 1620
            QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA
Sbjct: 1559 QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA 1618

Query: 1621 ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ 1680
            ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ
Sbjct: 1619 ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ 1678

Query: 1681 SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS 1740
            SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNT HQRAASTAPSSTSTPAAS
Sbjct: 1679 SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAAS 1738

Query: 1741 SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG 1800
            SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYS+ + + SDLMG
Sbjct: 1739 SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSMSLDKSSDLMG 1798

Query: 1801 LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA 1860
            LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA
Sbjct: 1799 LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA 1858

Query: 1861 SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY 1920
            SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY
Sbjct: 1859 SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY 1918

Query: 1921 ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL 1980
            ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL
Sbjct: 1919 ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL 1978

Query: 1981 LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF 2040
            LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF
Sbjct: 1979 LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF 2038

Query: 2041 EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT 2100
            EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT
Sbjct: 2039 EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT 2098

Query: 2101 KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE 2160
            KMSYAANLKNVMNMQNRQKK+G+EQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE
Sbjct: 2099 KMSYAANLKNVMNMQNRQKKKGKEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE 2158

Query: 2161 SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV 2220
            SEGPPLTSFRPQCSFMGMV+SHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV
Sbjct: 2159 SEGPPLTSFRPQCSFMGMVLSHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV 2218

Query: 2221 KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT 2280
            KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCAT PMAVHRVKVT
Sbjct: 2219 KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVT 2278

Query: 2281 FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER 2340
            FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER
Sbjct: 2279 FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER 2338

Query: 2341 EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER 2400
            EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER
Sbjct: 2339 EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER 2398

Query: 2401 LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS 2460
            LYPRVQAMQPAFASKITGMLL+  P+    LLASEDSLRARVDEAMELIIAHGRENGADS
Sbjct: 2399 LYPRVQAMQPAFASKITGMLLDY-PSSAASLLASEDSLRARVDEAMELIIAHGRENGADS 2457

Query: 2461 ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK 2520
            ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK
Sbjct: 2458 ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK 2517

Query: 2521 NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR 2580
            NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR
Sbjct: 2518 NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR 2577

Query: 2581 QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE 2640
            QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGV  PVTPQNVYEYVRK AE
Sbjct: 2578 QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAE 2637

Query: 2641 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES 2700
            HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES
Sbjct: 2638 HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES 2697

Query: 2701 GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ 2760
            GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ
Sbjct: 2698 GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ 2757

Query: 2761 HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2799
            HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV
Sbjct: 2758 HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2796


>gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3
            component n-recognin 5 isoform 2 [Homo sapiens]
          Length = 2277

 Score = 4460 bits (11569), Expect = 0.0
 Identities = 2252/2295 (98%), Positives = 2260/2295 (98%), Gaps = 18/2295 (0%)

Query: 505  MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES 564
            MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES
Sbjct: 1    MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES 60

Query: 565  VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA 624
            VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA
Sbjct: 61   VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA 120

Query: 625  SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG 684
            SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG
Sbjct: 121  SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG 180

Query: 685  TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT 744
            TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT
Sbjct: 181  TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT 240

Query: 745  EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA 804
            EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA
Sbjct: 241  EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA 300

Query: 805  GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA 864
            GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA
Sbjct: 301  GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA 360

Query: 865  AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILH 924
            AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQ   LEQNLQMLQTFISHRCDGNRNILH
Sbjct: 361  AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRF-LEQNLQMLQTFISHRCDGNRNILH 419

Query: 925  ACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSR 984
            ACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSR
Sbjct: 420  ACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSR 479

Query: 985  SLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILA 1044
            SLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPD        
Sbjct: 480  SLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPD-------- 531

Query: 1045 PAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRE 1104
                    AATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRE
Sbjct: 532  --------AATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRE 583

Query: 1105 LLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTN 1164
            LLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTN
Sbjct: 584  LLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTN 643

Query: 1165 PDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLK 1224
            PDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECA VCHKGHD KLK
Sbjct: 644  PDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLK 703

Query: 1225 RTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVA 1284
            RTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVA
Sbjct: 704  RTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVA 763

Query: 1285 RQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIM 1344
            RQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIM
Sbjct: 764  RQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIM 823

Query: 1345 FGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGT 1404
            FGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGT
Sbjct: 824  FGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGT 883

Query: 1405 LVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVF 1464
            LVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVF
Sbjct: 884  LVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVF 943

Query: 1465 QALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPS 1524
            QALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPS
Sbjct: 944  QALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPS 1003

Query: 1525 SDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDH 1584
            SDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDH
Sbjct: 1004 SDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDH 1063

Query: 1585 HDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVT 1644
            HDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVT
Sbjct: 1064 HDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVT 1123

Query: 1645 AATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHA 1704
            AATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHA
Sbjct: 1124 AATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHA 1183

Query: 1705 NGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAA 1764
            NGAAQAPRSMQWAVRNT HQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAA
Sbjct: 1184 NGAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAA 1243

Query: 1765 AAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDA 1824
            AAAALEASNASSYLTSASSLARAYS+ + + SDLMGLIPKYNHLVYSQIPAAVKLTYQDA
Sbjct: 1244 AAAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDA 1303

Query: 1825 VNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERM 1884
            VNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERM
Sbjct: 1304 VNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERM 1363

Query: 1885 TAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSL 1944
            TAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSL
Sbjct: 1364 TAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSL 1423

Query: 1945 KHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATL 2004
            KHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATL
Sbjct: 1424 KHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATL 1483

Query: 2005 NDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKE 2064
            NDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKE
Sbjct: 1484 NDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKE 1543

Query: 2065 DLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEE 2124
            DLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKK+G+E
Sbjct: 1544 DLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKE 1603

Query: 2125 QPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDM 2184
            QPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMV+SHDM
Sbjct: 1604 QPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDM 1663

Query: 2185 LLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEV 2244
            LLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEV
Sbjct: 1664 LLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEV 1723

Query: 2245 DRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFL 2304
            DRDRDLLIQQTMRQLNNHFGRRCAT PMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFL
Sbjct: 1724 DRDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFL 1783

Query: 2305 SNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDF 2364
            SNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDF
Sbjct: 1784 SNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDF 1843

Query: 2365 RRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELS 2424
            RRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLL+  
Sbjct: 1844 RRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDY- 1902

Query: 2425 PAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSS 2484
            P+    LLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSS
Sbjct: 1903 PSSAASLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSS 1962

Query: 2485 RSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNE 2544
            RSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNE
Sbjct: 1963 RSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNE 2022

Query: 2545 LCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAI 2604
            LCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAI
Sbjct: 2023 LCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAI 2082

Query: 2605 DLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPK 2664
            DLCKEEGGGQVELIPNGV  PVTPQNVYEYVRK AEHRMLVVAEQPLHAMRKGLLDVLPK
Sbjct: 2083 DLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPK 2142

Query: 2665 NSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMT 2724
            NSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMT
Sbjct: 2143 NSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMT 2202

Query: 2725 ERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILK 2784
            ERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILK
Sbjct: 2203 ERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILK 2262

Query: 2785 QKLLLAIKTKNFGFV 2799
            QKLLLAIKTKNFGFV
Sbjct: 2263 QKLLLAIKTKNFGFV 2277


>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
            protein ligase 1 [Homo sapiens]
          Length = 909

 Score =  123 bits (308), Expect = 3e-27
 Identities = 94/299 (31%), Positives = 147/299 (49%), Gaps = 23/299 (7%)

Query: 2506 YQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNW 2565
            +QP    +  P         LN FR  G+ILGL L   +L  I   R   K +LG  VN+
Sbjct: 625  FQPNSNSYVNPD-------HLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNY 677

Query: 2566 HDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIP 2625
             D A  DP   ++L Q IL +  SD       ++L F+++        +V L P G +I 
Sbjct: 678  QDVASIDPEYAKNL-QWILDNDISDL-----GLELTFSVETDVFGAMEEVPLKPGGGSIL 731

Query: 2626 VTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEV 2685
            VT  N  EYV+   E RM    +  ++A  +G    +P + ++     +  LL++G  E+
Sbjct: 732  VTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEI 791

Query: 2686 NVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----A 2741
            +V   I  T +     E  + ++Q   WFW +VE ++  ER  L+ F T S  +P    A
Sbjct: 792  DVSDWIKNTEYTS-GYEREDPVIQ---WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFA 847

Query: 2742 SEEGFQPMPSITIR--PPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2798
            +  G   + + TI   P     LPT++TCI+ L +P Y SK+ILK +LL+A+   ++G+
Sbjct: 848  NIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGY 906


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score =  115 bits (287), Expect = 8e-25
 Identities = 85/299 (28%), Positives = 139/299 (46%), Gaps = 20/299 (6%)

Query: 2508 PGKRGFYTPRPGKNTEAR-LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWH 2566
            PG R  YT  P  +     L+ F+ +GRI+   +  N L      R   K +LG+ V + 
Sbjct: 4085 PGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYT 4144

Query: 2567 DFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPNGVNIP 2625
            D    D   Y+ L  L+      + D      DL F+ ++ +E G  +V +L PNG NI 
Sbjct: 4145 DMESEDYHFYQGLVYLL------ENDVSTLGYDLTFSTEV-QEFGVCEVRDLKPNGANIL 4197

Query: 2626 VTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEV 2685
            VT +N  EYV    + RM     + L A  +G  +++PK  +   T ++  LL++G   +
Sbjct: 4198 VTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTI 4257

Query: 2686 NVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----A 2741
            ++  L S T ++     + +      +WFW  +      +R   + F T +  +P    A
Sbjct: 4258 DIDDLKSNTEYHKYQSNSIQ-----IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFA 4312

Query: 2742 SEEGFQPMPSITIRPPD--DQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2798
            + EG   +    I   D     LP+A+TC ++L +P Y S + L+  LLLAI+  + GF
Sbjct: 4313 ALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGF 4371



 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 34/106 (32%), Positives = 53/106 (50%), Gaps = 14/106 (13%)

Query: 1510 SEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADV 1569
            S+E   ++  P   S   +  +++  S  I+    +   +Q +   G +E++DD  S D 
Sbjct: 2377 SQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDD--SQDE 2434

Query: 1570 EEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELD 1615
            EE E       EED  D+QE+   E    EG  D+ D+DGS+MELD
Sbjct: 2435 EEEE-------EEDEEDDQEDDEGE----EGDEDD-DDDGSEMELD 2468



 Score = 40.4 bits (93), Expect = 0.025
 Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 18/184 (9%)

Query: 1513 LFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEV 1572
            LF  +    +  S+Q +  +   SS   ++P +   ++ Q      EE  D+   +V + 
Sbjct: 2263 LFGSKSASSKNKSEQDAQGASQDSSSNQQDPGEPGEAEVQ------EEDHDVTQTEVADG 2316

Query: 1573 EVVEG--------VAGEEDHHDEQEEHGEENAEAEGQHDEH-DEDGSDMELDLLAAAETE 1623
            ++++G        +AG+ +    QE   E   E E   DE  + DG      ++ +   E
Sbjct: 2317 DIMDGEAETDSVVIAGQPEVLSSQEMQVEN--ELEDLIDELLERDGGSGNSTIIVSRSGE 2374

Query: 1624 SDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDD 1683
             +S+ +    D A    S  +   A  E   + +     E+ +Q  DSS S+     S D
Sbjct: 2375 DESQEDVL-MDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQD 2433

Query: 1684 IEQE 1687
             E+E
Sbjct: 2434 EEEE 2437


>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
          Length = 823

 Score =  110 bits (274), Expect = 3e-23
 Identities = 84/294 (28%), Positives = 137/294 (46%), Gaps = 23/294 (7%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQN-------ELCPITLNRHVIKVLLGRKVNWHDF 2568
            P P +    RL  +   GR++G CL ++       +L      R  +  ++G ++++  F
Sbjct: 539  PNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYF 598

Query: 2569 AFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEG--GGQVELIPNGVNIPV 2626
               DP  Y+S    IL +  S+       M+L FA +   + G     VEL+  G   PV
Sbjct: 599  ETDDPEFYKSKVCFILNNDMSE-------MELVFAEEKYNKSGQLDKVVELMTGGAQTPV 651

Query: 2627 TPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVN 2686
            T  N   Y+   A++R+    ++ +    KGL +++P+N L      +  LL+ G G+++
Sbjct: 652  TNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDIS 711

Query: 2687 VQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGF 2746
            V    +       S    EK++   RWFW++V  ++  E   L+ F T S  LP    GF
Sbjct: 712  VSDFKAHAVVVGGSWHFREKVM---RWFWTVVSSLTQEELARLLQFTTGSSQLPPG--GF 766

Query: 2747 QPM-PSI-TIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2798
              + PS   I  P    LPTA+TC ++L +P Y S + + + L LAI     GF
Sbjct: 767  AALCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
            sapiens]
          Length = 757

 Score =  104 bits (260), Expect = 1e-21
 Identities = 77/278 (27%), Positives = 127/278 (45%), Gaps = 25/278 (8%)

Query: 2526 LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILA 2585
            L+ F  +GRI+GL +               K LLG+ +   D    DP +++SL  ++  
Sbjct: 486  LSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN 545

Query: 2586 SQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLV 2645
              +   D  F     AF   L       Q EL PNG N+PVT +N  EYVR Y   R + 
Sbjct: 546  DITPVLDHTFCVEHNAFGRIL-------QHELKPNGRNVPVTEENKKEYVRLYVNWRFMR 598

Query: 2646 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 2705
              E    A++KG  +++P++ L+    ++  L++ G  ++++    S T       ++  
Sbjct: 599  GIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADS-- 656

Query: 2706 KLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMP-----------SITI 2754
                  RWFW  VE      R  L+ F T S  +P   +GF+ +            +I +
Sbjct: 657  ---NIVRWFWQAVETFDEERRARLLQFVTGSTRVPL--QGFKALQGSTGAAGPRLFTIHL 711

Query: 2755 RPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
               +  +LP A+TC +R+ +P Y S + L +KLL A++
Sbjct: 712  IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
            sapiens]
          Length = 731

 Score =  104 bits (260), Expect = 1e-21
 Identities = 77/278 (27%), Positives = 127/278 (45%), Gaps = 25/278 (8%)

Query: 2526 LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILA 2585
            L+ F  +GRI+GL +               K LLG+ +   D    DP +++SL  ++  
Sbjct: 460  LSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN 519

Query: 2586 SQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLV 2645
              +   D  F     AF   L       Q EL PNG N+PVT +N  EYVR Y   R + 
Sbjct: 520  DITPVLDHTFCVEHNAFGRIL-------QHELKPNGRNVPVTEENKKEYVRLYVNWRFMR 572

Query: 2646 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 2705
              E    A++KG  +++P++ L+    ++  L++ G  ++++    S T       ++  
Sbjct: 573  GIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADS-- 630

Query: 2706 KLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMP-----------SITI 2754
                  RWFW  VE      R  L+ F T S  +P   +GF+ +            +I +
Sbjct: 631  ---NIVRWFWQAVETFDEERRARLLQFVTGSTRVPL--QGFKALQGSTGAAGPRLFTIHL 685

Query: 2755 RPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
               +  +LP A+TC +R+ +P Y S + L +KLL A++
Sbjct: 686  IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723


>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
          Length = 872

 Score =  103 bits (256), Expect = 3e-21
 Identities = 98/361 (27%), Positives = 168/361 (46%), Gaps = 21/361 (5%)

Query: 2442 VDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDN 2501
            +D+A+  +     EN AD    L +    E+   E     G S+    + +++  + D  
Sbjct: 530  IDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEG----GVSKEFFQLVVEEIFNPDIG 585

Query: 2502 APLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2561
               + +  K  ++ P   + TE +   F  IG +LGL +  N +  +     V + L+G+
Sbjct: 586  MFTYDESTKLFWFNPSSFE-TEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGK 641

Query: 2562 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPN 2620
            K  + D     PV+Y+SL+ L+    + + D     M + F I      G   + +L  N
Sbjct: 642  KGTFRDLGDSHPVLYQSLKDLLEYEGNVEDD-----MMITFQISQTDLFGNPMMYDLKEN 696

Query: 2621 GVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDL-TAEDFRLLV 2679
            G  IP+T +N  E+V  Y+++ +    E+   A R+G   V  ++ L+ L   E+  LL+
Sbjct: 697  GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756

Query: 2680 NGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSL 2739
             G   ++ Q L   T +  + G   + +L   R FW IV   +  +++  + F T +   
Sbjct: 757  CGSRNLDFQALEETTEY--DGGYTRDSVLI--REFWEIVHSFTDEQKRLFLQFTTGTDRA 812

Query: 2740 PASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK-TKNFGF 2798
            P    G   M  I    PD + LPT++TC + L +P YSSK+ LK++LL AI   K FG 
Sbjct: 813  PVGGLGKLKM-IIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 871

Query: 2799 V 2799
            +
Sbjct: 872  L 872


>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
          Length = 852

 Score =  103 bits (256), Expect = 3e-21
 Identities = 98/361 (27%), Positives = 168/361 (46%), Gaps = 21/361 (5%)

Query: 2442 VDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDN 2501
            +D+A+  +     EN AD    L +    E+   E     G S+    + +++  + D  
Sbjct: 510  IDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEG----GVSKEFFQLVVEEIFNPDIG 565

Query: 2502 APLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2561
               + +  K  ++ P   + TE +   F  IG +LGL +  N +  +     V + L+G+
Sbjct: 566  MFTYDESTKLFWFNPSSFE-TEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGK 621

Query: 2562 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPN 2620
            K  + D     PV+Y+SL+ L+    + + D     M + F I      G   + +L  N
Sbjct: 622  KGTFRDLGDSHPVLYQSLKDLLEYEGNVEDD-----MMITFQISQTDLFGNPMMYDLKEN 676

Query: 2621 GVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDL-TAEDFRLLV 2679
            G  IP+T +N  E+V  Y+++ +    E+   A R+G   V  ++ L+ L   E+  LL+
Sbjct: 677  GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736

Query: 2680 NGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSL 2739
             G   ++ Q L   T +  + G   + +L   R FW IV   +  +++  + F T +   
Sbjct: 737  CGSRNLDFQALEETTEY--DGGYTRDSVLI--REFWEIVHSFTDEQKRLFLQFTTGTDRA 792

Query: 2740 PASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK-TKNFGF 2798
            P    G   M  I    PD + LPT++TC + L +P YSSK+ LK++LL AI   K FG 
Sbjct: 793  PVGGLGKLKM-IIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 851

Query: 2799 V 2799
            +
Sbjct: 852  L 852


>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
          Length = 875

 Score =  103 bits (256), Expect = 3e-21
 Identities = 98/361 (27%), Positives = 168/361 (46%), Gaps = 21/361 (5%)

Query: 2442 VDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDN 2501
            +D+A+  +     EN AD    L +    E+   E     G S+    + +++  + D  
Sbjct: 533  IDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEG----GVSKEFFQLVVEEIFNPDIG 588

Query: 2502 APLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2561
               + +  K  ++ P   + TE +   F  IG +LGL +  N +  +     V + L+G+
Sbjct: 589  MFTYDESTKLFWFNPSSFE-TEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGK 644

Query: 2562 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPN 2620
            K  + D     PV+Y+SL+ L+    + + D     M + F I      G   + +L  N
Sbjct: 645  KGTFRDLGDSHPVLYQSLKDLLEYEGNVEDD-----MMITFQISQTDLFGNPMMYDLKEN 699

Query: 2621 GVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDL-TAEDFRLLV 2679
            G  IP+T +N  E+V  Y+++ +    E+   A R+G   V  ++ L+ L   E+  LL+
Sbjct: 700  GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759

Query: 2680 NGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSL 2739
             G   ++ Q L   T +  + G   + +L   R FW IV   +  +++  + F T +   
Sbjct: 760  CGSRNLDFQALEETTEY--DGGYTRDSVLI--REFWEIVHSFTDEQKRLFLQFTTGTDRA 815

Query: 2740 PASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK-TKNFGF 2798
            P    G   M  I    PD + LPT++TC + L +P YSSK+ LK++LL AI   K FG 
Sbjct: 816  PVGGLGKLKM-IIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 874

Query: 2799 V 2799
            +
Sbjct: 875  L 875


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
            sapiens]
          Length = 748

 Score =  102 bits (255), Expect = 4e-21
 Identities = 84/299 (28%), Positives = 133/299 (44%), Gaps = 27/299 (9%)

Query: 2506 YQPGKRGFYT----PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2561
            +Q  +   YT    P    N E  L+ F  +GRI+G+ +               K LLG+
Sbjct: 457  FQYSRDDIYTLQINPDSAVNPE-HLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGK 515

Query: 2562 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNG 2621
             +   D    DP ++ SL  ++    +   D  F     A+   +       Q EL PNG
Sbjct: 516  SITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEII-------QHELKPNG 568

Query: 2622 VNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNG 2681
             +IPV  +N  EYVR Y   R L   E    A++KG  +V+P++ L+    ++  L++ G
Sbjct: 569  KSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICG 628

Query: 2682 CGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPA 2741
             G+++V      T     + ++        +WFW  VE      R  L+ F T S  +P 
Sbjct: 629  LGKIDVNDWKVNTRLKHCTPDS-----NIVKWFWKAVEFFDEERRARLLQFVTGSSRVPL 683

Query: 2742 SEEGFQPMPS------ITIRPPD--DQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
              +GF+ +         TI   D    +LP A+TC +R+ +P Y S + L +KLL AI+
Sbjct: 684  --QGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIE 740


>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
            ligase 2 [Homo sapiens]
          Length = 1572

 Score =  101 bits (251), Expect = 1e-20
 Identities = 83/280 (29%), Positives = 131/280 (46%), Gaps = 27/280 (9%)

Query: 2529 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 2588
            FR  GRILGL L+   L      R   K LL    +  D  + D   ++SL+ +      
Sbjct: 1307 FRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWM------ 1360

Query: 2589 SDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVNIPVTPQNVYEYVRKYAEHRMLV 2645
             D D +   +DL F ++   EE  GQ+   EL P G NIPVT +N  EY+ +  + R+  
Sbjct: 1361 KDND-IHDILDLTFTVN---EEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIER 1416

Query: 2646 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 2705
               Q   ++ +G  +V+    +    A +  L++ G  E+++    + T +     +N  
Sbjct: 1417 GVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHI 1476

Query: 2706 KLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQ-------PMPSITIRPPD 2758
             +    RWFW+ VE+ +  +R  L+ F T + S+P   EGF        P      +   
Sbjct: 1477 VI----RWFWAAVERFNNEQRLRLLQFVTGTSSIP--YEGFASLRGSNGPRRFCVEKWGK 1530

Query: 2759 DQHLPTANTCISRLYVPLYSSKQILKQKLLLAI-KTKNFG 2797
               LP A+TC +RL +P Y S  +L +KLL A+ +T  FG
Sbjct: 1531 ITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFG 1570


>gi|222352183 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  100 bits (249), Expect = 2e-20
 Identities = 80/285 (28%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 576  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVNIPVTPQNVY 2632
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG  I VT +N  
Sbjct: 636  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 684

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 685  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 744

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 745  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 800

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 801  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 845


>gi|21361472 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score =  100 bits (249), Expect = 2e-20
 Identities = 80/285 (28%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 677  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 736

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVNIPVTPQNVY 2632
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG  I VT +N  
Sbjct: 737  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 785

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 786  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 845

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 846  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 901

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 902  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 946


>gi|222352094 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  100 bits (249), Expect = 2e-20
 Identities = 80/285 (28%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 556  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 615

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVNIPVTPQNVY 2632
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG  I VT +N  
Sbjct: 616  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 664

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 665  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 724

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 725  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 781  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 825


>gi|222352092 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  100 bits (249), Expect = 2e-20
 Identities = 80/285 (28%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 556  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 615

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVNIPVTPQNVY 2632
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG  I VT +N  
Sbjct: 616  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 664

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 665  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 724

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 725  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 781  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 825


>gi|222352090 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score =  100 bits (249), Expect = 2e-20
 Identities = 80/285 (28%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 669  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 728

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVNIPVTPQNVY 2632
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG  I VT +N  
Sbjct: 729  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 777

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 778  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 837

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 838  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 893

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 894  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 938


>gi|222352088 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score =  100 bits (249), Expect = 2e-20
 Identities = 80/285 (28%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 689  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 748

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVNIPVTPQNVY 2632
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG  I VT +N  
Sbjct: 749  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 797

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 798  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 857

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 858  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 913

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 914  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 958


>gi|222352086 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score =  100 bits (249), Expect = 2e-20
 Identities = 80/285 (28%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 697  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 756

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVNIPVTPQNVY 2632
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG  I VT +N  
Sbjct: 757  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 805

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 806  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 865

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 866  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 921

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 922  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 966


>gi|222352084 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  100 bits (249), Expect = 2e-20
 Identities = 80/285 (28%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 576  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVNIPVTPQNVY 2632
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG  I VT +N  
Sbjct: 636  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 684

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 685  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 744

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 745  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 800

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 801  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 845


>gi|222352082 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  100 bits (249), Expect = 2e-20
 Identities = 80/285 (28%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 576  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVNIPVTPQNVY 2632
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG  I VT +N  
Sbjct: 636  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 684

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 685  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 744

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 745  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 800

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 801  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 845


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
          Length = 862

 Score = 96.3 bits (238), Expect = 4e-19
 Identities = 78/283 (27%), Positives = 133/283 (46%), Gaps = 27/283 (9%)

Query: 2526 LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILA 2585
            L  FR IGR + + L   +      +    K +L + V   D    DP  Y SL   +  
Sbjct: 594  LKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIW-VKE 652

Query: 2586 SQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVNIPVTPQNVYEYVRKYAEHR 2642
            +   + D     +++ F++D   +E  G++   +L PNG NI VT +N  EY+R  AE R
Sbjct: 653  NNIEECD-----LEMYFSVD---KEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWR 704

Query: 2643 MLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGE 2702
            +    E+   A  +G  ++LP+  L+   A++  +L+ G  E+++        +   +  
Sbjct: 705  LSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYART 764

Query: 2703 NAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQ-------PMPSITIR 2755
            + + +     WFW  V+++   +R  L+ F T +  LP    GF        P      +
Sbjct: 765  SKQIM-----WFWQFVKEIDNEKRMRLLQFVTGTCRLPVG--GFADLMGSNGPQKFCIEK 817

Query: 2756 PPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI-KTKNFG 2797
               +  LP ++TC +RL +P Y S + LK+KLL AI +T+ FG
Sbjct: 818  VGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 860


>gi|114520609 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score = 96.3 bits (238), Expect = 4e-19
 Identities = 80/285 (28%), Positives = 132/285 (46%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 622  PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 681

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 2632
            Y SLR ++     +D     + +DL F ID   EE  GQ    EL   G  I VT +N  
Sbjct: 682  YNSLRWIL----ENDP----TELDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 730

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 731  EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 790

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             T + +    N + +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 791  HTKYKNGYSANHQVI----QWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 846

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
              S T+      + LP A+TC +RL +P Y S + L  KL +AI+
Sbjct: 847  PQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIE 891


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score = 96.3 bits (238), Expect = 4e-19
 Identities = 80/285 (28%), Positives = 132/285 (46%), Gaps = 23/285 (8%)

Query: 2516 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2575
            P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 969  PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 1028

Query: 2576 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVNIPVTPQNVY 2632
            Y SLR ++     +D     + +DL F ID   EE  GQ    EL   G  I VT +N  
Sbjct: 1029 YNSLRWIL----ENDP----TELDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 1077

Query: 2633 EYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2692
            EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 1078 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 1137

Query: 2693 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2748
             T + +    N + +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 1138 HTKYKNGYSANHQVI----QWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 1193

Query: 2749 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
              S T+      + LP A+TC +RL +P Y S + L  KL +AI+
Sbjct: 1194 PQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIE 1238


>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
          Length = 1606

 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 82/284 (28%), Positives = 130/284 (45%), Gaps = 23/284 (8%)

Query: 2523 EARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL 2582
            E  L  FR  GRILGL L+   L      R   K LL    +  D  + D   ++SL+ +
Sbjct: 1335 ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWM 1394

Query: 2583 ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVNIPVTPQNVYEYVRKYA 2639
                     + +   +DL F ++   EE  GQV   EL   G N  VT +N  EY+ +  
Sbjct: 1395 -------KDNNITDILDLTFTVN---EEVFGQVTERELKSGGANTQVTEKNKKEYIERMV 1444

Query: 2640 EHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDE 2699
            + R+     Q   A+ +G  +V+    +    A +  L++ G  E+++    + T +   
Sbjct: 1445 KWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEY--R 1502

Query: 2700 SGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQPMPSITIR 2755
             G +   L+   RWFW+ VE+ +  +R  L+ F T + S+P    A+  G   +    I 
Sbjct: 1503 GGYHDGHLV--IRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE 1560

Query: 2756 P-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI-KTKNFG 2797
                   LP A+TC +RL +P Y S  +L +KLL A+ +T  FG
Sbjct: 1561 KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFG 1604


>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
          Length = 1083

 Score = 89.4 bits (220), Expect = 5e-17
 Identities = 86/298 (28%), Positives = 146/298 (48%), Gaps = 23/298 (7%)

Query: 2505 FYQPGKRGFYTPRPGKNTEARLNCFRN---IGRILGLCLLQNELCPITLNRHVIKVLLGR 2561
            F++    G   P P        +  R+   +GR+LG  L +N L  +      +  LLG 
Sbjct: 791  FFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGT 850

Query: 2562 K--VNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELI 2618
               V+ H  A  DP +Y++L  L L S   D +     + L F + +  + G  QV EL 
Sbjct: 851  SADVDIHHLASLDPEVYKNL--LFLKSYEDDVEE----LGLNFTV-VNNDLGEAQVVELK 903

Query: 2619 PNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLL 2678
              G +IPVT  N   Y+   A++R+     Q   A R+GL +V+    L     ++ ++L
Sbjct: 904  FGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVL 963

Query: 2679 VNGCG-EVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSP 2737
            ++G    ++++ L SFT+++   G +A+      + FW +VE  +  E++ L+ F TS  
Sbjct: 964  ISGAQVPISLEDLKSFTNYS--GGYSADH--PVIKVFWRVVEGFTDEEKRKLLKFVTSCS 1019

Query: 2738 SLPASEEGFQPM-PSITIR--PPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2792
              P    GF+ + P+  I     D + LPTA+TC++ L +P +  + +L+ KLL AI+
Sbjct: 1020 RPPLL--GFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIE 1075


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 74/278 (26%), Positives = 131/278 (47%), Gaps = 15/278 (5%)

Query: 2518 PGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYE 2577
            P    +  L  F+ +G ++G+ +   +   + L   V K L    +   D    D +  +
Sbjct: 4568 PSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQ 4627

Query: 2578 SLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRK 2637
            +L  ++    S   +  F  M +     + +   G  V +IP G +IP+T  N  EYV +
Sbjct: 4628 TLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVER 4686

Query: 2638 YAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFN 2697
              E+R+  +  Q + A+R+G+  ++P   L  LTA+    +V G  E++V++L     + 
Sbjct: 4687 AIEYRLHEMDRQ-VAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR 4745

Query: 2698 DESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPAS----EEGFQPMPSIT 2753
            +   ++     Q  +WFW  +E+ S  ER   + F +    LPA+     + FQ M    
Sbjct: 4746 EVDEQH-----QLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMK--V 4798

Query: 2754 IRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI 2791
             RP D   LPT+ TC  +L +P YSS+ ++ ++L  AI
Sbjct: 4799 DRPYDS--LPTSQTCFFQLRLPPYSSQLVMAERLRYAI 4834


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score = 82.8 bits (203), Expect = 4e-15
 Identities = 77/286 (26%), Positives = 122/286 (42%), Gaps = 20/286 (6%)

Query: 2511 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 2570
            R  Y   P        + FR +G +LG+ +       + L   V K L G  +   D + 
Sbjct: 4515 RDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSE 4574

Query: 2571 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQN 2630
             D    + +  L+    +      F AM L F +       G  ++L     +I  T  N
Sbjct: 4575 VDK---DFIPGLMYIRDNEATSEEFEAMSLPFTVP---SASGQDIQLSSKHTHI--TLDN 4626

Query: 2631 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 2690
              EYVR    +R+    EQ + A+R+G+  V+P   L   T  +   +V G  ++ + +L
Sbjct: 4627 RAEYVRLAINYRLHEFDEQ-VAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLL 4685

Query: 2691 ISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMP 2750
             S  ++  +  E +  L+Q   WFW ++E  S TER   + F      LP +   F+   
Sbjct: 4686 KSVATY--KGIEPSASLIQ---WFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRD 4740

Query: 2751 SIT-----IRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI 2791
             +        PPD   LP + TC   L +P YS KQ+L++KL  AI
Sbjct: 4741 FVIQVLDKYNPPD-HFLPESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785



 Score = 40.4 bits (93), Expect = 0.025
 Identities = 23/107 (21%), Positives = 48/107 (44%), Gaps = 4/107 (3%)

Query: 382  LAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENN 441
            +A++  G +Y W   +     +  +  +  PR    GL  +K++ ++  S+     TE+ 
Sbjct: 4210 VALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQV-QGLQGKKVIAIATGSLHCVCCTEDG 4268

Query: 442  KVATWVDETLSSVASKLEHTAQ---TYSELQGERIVSLHCCALYTCA 485
            +V TW D     +     +  Q     + LQG+++  + C + +T A
Sbjct: 4269 EVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLA 4315



 Score = 36.6 bits (83), Expect = 0.36
 Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 5/122 (4%)

Query: 379  SELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVA- 437
            S   A++S GELY W   E     +  N +   P+   + L +  I +   +    T+A 
Sbjct: 3109 SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLAL 3168

Query: 438  TENNKVATWVDETLSSV---ASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYW- 493
            T+   V +W D     +    S+  +  Q    L G+ +  + C A ++ A  ++ + W 
Sbjct: 3169 TDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWT 3228

Query: 494  WG 495
            WG
Sbjct: 3229 WG 3230



 Score = 36.2 bits (82), Expect = 0.47
 Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 12/114 (10%)

Query: 333 GSTSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQ 392
           G   K G    D   TP      L E LQ   D D  K  C G+ +S  +A++  G++Y 
Sbjct: 632 GDYGKLGRGGSDGCKTP-----KLIEKLQ---DLDVVKVRC-GSQFS--IALTKDGQVYS 680

Query: 393 WKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATW 446
           W   +++   +     + +P+    GL  +K++ ++A S      TE+++V +W
Sbjct: 681 WGKGDNQRLGHGTEEHVRYPKL-LEGLQGKKVIDVAAGSTHCLALTEDSEVHSW 733



 Score = 35.0 bits (79), Expect = 1.0
 Identities = 30/132 (22%), Positives = 54/132 (40%), Gaps = 7/132 (5%)

Query: 370  KFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSA 429
            K + + +     LA+SS+GE+Y W  +E     +        PR     L   ++V ++A
Sbjct: 4040 KKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPR-VIESLRGIEVVDVAA 4098

Query: 430  NSIRATVATENNKVATWVD---ETLSSVASKLEHTAQTYSELQGERIVSLHC---CALYT 483
                +   T    + TW       L    S+ +   +    LQG R+V + C    A   
Sbjct: 4099 GGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTL 4158

Query: 484  CAQLENSLYWWG 495
            C   +++++ WG
Sbjct: 4159 CLTDDDTVWSWG 4170



 Score = 33.1 bits (74), Expect = 4.0
 Identities = 24/115 (20%), Positives = 52/115 (45%), Gaps = 8/115 (6%)

Query: 375  GALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFL-GLTNEKIVLLSANSIR 433
            GA +S  LA++  G +  W W + + +R      +H  +   + GL  +KIV ++  ++ 
Sbjct: 3213 GAQFS--LALTKSGVV--WTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3268

Query: 434  ATVATENNKVATWVDE---TLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCA 485
                T++ +V  W D       +  + +         L+G++I  + C + ++ A
Sbjct: 3269 CLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3323


>gi|157738609 HECT domain containing 3 [Homo sapiens]
          Length = 861

 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 80/286 (27%), Positives = 126/286 (44%), Gaps = 29/286 (10%)

Query: 2511 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWH-DFA 2569
            R  Y P P     A+   +  IG+++G  L   E   + L   V K L G +V+W  DF 
Sbjct: 583  RDMYVPNPSCRDFAK---YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFP 639

Query: 2570 FFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQ 2629
              D V+ + L   ++     +        +L F   L  ++    VELIP G  I V   
Sbjct: 640  AVDSVLVKLLE--VMEGMDKETFEFKFGKELTFTTVLSDQQ---VVELIPGGAGIVVGYG 694

Query: 2630 NVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQM 2689
            +   +++   + R+    EQ + AM+ GLL V+P+  L+ LT ++    V G  EV V  
Sbjct: 695  DRSRFIQLVQKARLEESKEQ-VAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDA 753

Query: 2690 LISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM 2749
            L   T F D   E ++  +Q+   FW  +   +  +R   + F T    LPA        
Sbjct: 754  LRKLTRFED--FEPSDSRVQY---FWEALNNFTNEDRSRFLRFVTGRSRLPA-------- 800

Query: 2750 PSITIRP-----PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLA 2790
              I I P          LP ++TC S L++P Y+S ++ ++KL  A
Sbjct: 801  -RIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 109,821,786
Number of Sequences: 37866
Number of extensions: 5359053
Number of successful extensions: 38105
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 224
Number of HSP's successfully gapped in prelim test: 388
Number of HSP's that attempted gapping in prelim test: 29601
Number of HSP's gapped (non-prelim): 6088
length of query: 2799
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2679
effective length of database: 13,703,598
effective search space: 36711939042
effective search space used: 36711939042
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.