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Search of human proteins with 145309304
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3
[Homo sapiens]
(3312 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 6731 0.0
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 2980 0.0
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 2815 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 598 e-170
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 473 e-132
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 465 e-130
gi|16933557 dachsous 1 precursor [Homo sapiens] 431 e-120
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 395 e-109
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 378 e-104
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 363 2e-99
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 334 8e-91
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 323 2e-87
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 323 2e-87
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens] 298 6e-80
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens] 298 6e-80
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 291 6e-78
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 291 6e-78
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 291 6e-78
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ... 291 6e-78
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 288 5e-77
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 288 5e-77
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 288 5e-77
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 278 5e-74
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 278 5e-74
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 278 5e-74
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 278 5e-74
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 278 5e-74
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 278 5e-74
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 278 5e-74
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 278 5e-74
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 6731 bits (17463), Expect = 0.0
Identities = 3312/3312 (100%), Positives = 3312/3312 (100%)
Query: 1 MMARRPPWRGLGGRSTPILLLLLLSLFPLSQEELGGGGHQGWDPGLAATTGPRAHIGGGA 60
MMARRPPWRGLGGRSTPILLLLLLSLFPLSQEELGGGGHQGWDPGLAATTGPRAHIGGGA
Sbjct: 1 MMARRPPWRGLGGRSTPILLLLLLSLFPLSQEELGGGGHQGWDPGLAATTGPRAHIGGGA 60
Query: 61 LALCPESSGVREDGGPGLGVREPIFVGLRGRRQSARNSRGPPEQPNEELGIEHGVQPLGS 120
LALCPESSGVREDGGPGLGVREPIFVGLRGRRQSARNSRGPPEQPNEELGIEHGVQPLGS
Sbjct: 61 LALCPESSGVREDGGPGLGVREPIFVGLRGRRQSARNSRGPPEQPNEELGIEHGVQPLGS 120
Query: 121 RERETGQGPGSVLYWRPEVSSCGRTGPLQRGSLSPGALSSGVPGSGNSSPLPSDFLIRHH 180
RERETGQGPGSVLYWRPEVSSCGRTGPLQRGSLSPGALSSGVPGSGNSSPLPSDFLIRHH
Sbjct: 121 RERETGQGPGSVLYWRPEVSSCGRTGPLQRGSLSPGALSSGVPGSGNSSPLPSDFLIRHH 180
Query: 181 GPKPVSSQRNAGTGSRKRVGTARCCGELWATGSKGQGERATTSGAERTAPRRNCLPGASG 240
GPKPVSSQRNAGTGSRKRVGTARCCGELWATGSKGQGERATTSGAERTAPRRNCLPGASG
Sbjct: 181 GPKPVSSQRNAGTGSRKRVGTARCCGELWATGSKGQGERATTSGAERTAPRRNCLPGASG 240
Query: 241 SGPELDSAPRTARTAPASGSAPRESRTAPEPAPKRMRSRGLFRCRFLPQRPGPRPPGLPA 300
SGPELDSAPRTARTAPASGSAPRESRTAPEPAPKRMRSRGLFRCRFLPQRPGPRPPGLPA
Sbjct: 241 SGPELDSAPRTARTAPASGSAPRESRTAPEPAPKRMRSRGLFRCRFLPQRPGPRPPGLPA 300
Query: 301 RPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRL 360
RPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRL
Sbjct: 301 RPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRL 360
Query: 361 VYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVA 420
VYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVA
Sbjct: 361 VYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVA 420
Query: 421 VTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARA 480
VTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARA
Sbjct: 421 VTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARA 480
Query: 481 AAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEND 540
AAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEND
Sbjct: 481 AAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEND 540
Query: 541 NAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTG 600
NAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTG
Sbjct: 541 NAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTG 600
Query: 601 EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSV 660
EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSV
Sbjct: 601 EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSV 660
Query: 661 LENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVE 720
LENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVE
Sbjct: 661 LENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVE 720
Query: 721 HYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTA 780
HYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTA
Sbjct: 721 HYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTA 780
Query: 781 VDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHD 840
VDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHD
Sbjct: 781 VDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHD 840
Query: 841 HCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
HCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN
Sbjct: 841 HCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
Query: 901 LPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ 960
LPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ
Sbjct: 901 LPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ 960
Query: 961 FVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVR 1020
FVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVR
Sbjct: 961 FVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVR 1020
Query: 1021 TVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENS 1080
TVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENS
Sbjct: 1021 TVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENS 1080
Query: 1081 IVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVI 1140
IVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVI
Sbjct: 1081 IVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVI 1140
Query: 1141 VVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDP 1200
VVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDP
Sbjct: 1141 VVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDP 1200
Query: 1201 DVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCV 1260
DVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCV
Sbjct: 1201 DVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCV 1260
Query: 1261 LRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTD 1320
LRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTD
Sbjct: 1261 LRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTD 1320
Query: 1321 VGGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCL 1380
VGGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCL
Sbjct: 1321 VGGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCL 1380
Query: 1381 REPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDLCY 1440
REPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDLCY
Sbjct: 1381 REPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDLCY 1440
Query: 1441 SNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRC 1500
SNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRC
Sbjct: 1441 SNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRC 1500
Query: 1501 QCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNE 1560
QCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNE
Sbjct: 1501 QCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNE 1560
Query: 1561 KHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQ 1620
KHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQ
Sbjct: 1561 KHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQ 1620
Query: 1621 GPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLP 1680
GPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLP
Sbjct: 1621 GPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLP 1680
Query: 1681 ENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSER 1740
ENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSER
Sbjct: 1681 ENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSER 1740
Query: 1741 WGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQG 1800
WGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQG
Sbjct: 1741 WGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQG 1800
Query: 1801 VLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPG 1860
VLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPG
Sbjct: 1801 VLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPG 1860
Query: 1861 GRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQGVW 1920
GRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQGVW
Sbjct: 1861 GRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQGVW 1920
Query: 1921 LGSTPSGSPALLPPSHRVNAEPGCVVTNACASGPCPPHADCRDLWQTFSCTCQPGYYGPG 1980
LGSTPSGSPALLPPSHRVNAEPGCVVTNACASGPCPPHADCRDLWQTFSCTCQPGYYGPG
Sbjct: 1921 LGSTPSGSPALLPPSHRVNAEPGCVVTNACASGPCPPHADCRDLWQTFSCTCQPGYYGPG 1980
Query: 1981 CVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPTCGPC 2040
CVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPTCGPC
Sbjct: 1981 CVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPTCGPC 2040
Query: 2041 NCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQCPCRP 2100
NCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQCPCRP
Sbjct: 2041 NCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQCPCRP 2100
Query: 2101 GALGRQCNSCDSPFAEVTASGCRVLYDACPKSLRSGVWWPQTKFGVLATVPCPRGALGAA 2160
GALGRQCNSCDSPFAEVTASGCRVLYDACPKSLRSGVWWPQTKFGVLATVPCPRGALGAA
Sbjct: 2101 GALGRQCNSCDSPFAEVTASGCRVLYDACPKSLRSGVWWPQTKFGVLATVPCPRGALGAA 2160
Query: 2161 VRLCDEAQGWLEPDLFNCTSPAFRELSLLLDGLELNKTALDTMEAKKLAQRLREVTGHTD 2220
VRLCDEAQGWLEPDLFNCTSPAFRELSLLLDGLELNKTALDTMEAKKLAQRLREVTGHTD
Sbjct: 2161 VRLCDEAQGWLEPDLFNCTSPAFRELSLLLDGLELNKTALDTMEAKKLAQRLREVTGHTD 2220
Query: 2221 HYFSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLWAGSALLAPETGDLWAAL 2280
HYFSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLWAGSALLAPETGDLWAAL
Sbjct: 2221 HYFSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLWAGSALLAPETGDLWAAL 2280
Query: 2281 GQRAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPNIMLSIDRMEHPSSPRGA 2340
GQRAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPNIMLSIDRMEHPSSPRGA
Sbjct: 2281 GQRAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPNIMLSIDRMEHPSSPRGA 2340
Query: 2341 RRYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSSIENSTTSSVVPPPAPPE 2400
RRYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSSIENSTTSSVVPPPAPPE
Sbjct: 2341 RRYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSSIENSTTSSVVPPPAPPE 2400
Query: 2401 PEPGISIIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVVSVAVFHGRNFLRGILE 2460
PEPGISIIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVVSVAVFHGRNFLRGILE
Sbjct: 2401 PEPGISIIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVVSVAVFHGRNFLRGILE 2460
Query: 2461 SPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSHARCRCSRTGTF 2520
SPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSHARCRCSRTGTF
Sbjct: 2461 SPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSHARCRCSRTGTF 2520
Query: 2521 GVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNVRGIHANVAA 2580
GVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNVRGIHANVAA
Sbjct: 2521 GVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNVRGIHANVAA 2580
Query: 2581 ALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQVEPRNVDRG 2640
ALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQVEPRNVDRG
Sbjct: 2581 ALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQVEPRNVDRG 2640
Query: 2641 AMRFYHALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFAGPVVLVIVMNGTM 2700
AMRFYHALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFAGPVVLVIVMNGTM
Sbjct: 2641 AMRFYHALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFAGPVVLVIVMNGTM 2700
Query: 2701 FLLAARTSCSTGQREAKKTSALTLRSSFLLLLLVSASWLFGLLAVNHSILAFHYLHAGLC 2760
FLLAARTSCSTGQREAKKTSALTLRSSFLLLLLVSASWLFGLLAVNHSILAFHYLHAGLC
Sbjct: 2701 FLLAARTSCSTGQREAKKTSALTLRSSFLLLLLVSASWLFGLLAVNHSILAFHYLHAGLC 2760
Query: 2761 GLQGLAVLLLFCVLNADARAAWMPACLGRKAAPEEARPAPGLGPGAYNNTALFEESGLIR 2820
GLQGLAVLLLFCVLNADARAAWMPACLGRKAAPEEARPAPGLGPGAYNNTALFEESGLIR
Sbjct: 2761 GLQGLAVLLLFCVLNADARAAWMPACLGRKAAPEEARPAPGLGPGAYNNTALFEESGLIR 2820
Query: 2821 ITLGASTVSSVSSARSGRTQDQDSQRGRSYLRDNVLVRHGSAADHTDHSLQAHAGPTDLD 2880
ITLGASTVSSVSSARSGRTQDQDSQRGRSYLRDNVLVRHGSAADHTDHSLQAHAGPTDLD
Sbjct: 2821 ITLGASTVSSVSSARSGRTQDQDSQRGRSYLRDNVLVRHGSAADHTDHSLQAHAGPTDLD 2880
Query: 2881 VAMFHRDAGADSDSDSDLSLEEERSLSIPSSESEDNGRTRGRFQRPLCRAAQSERLLTHP 2940
VAMFHRDAGADSDSDSDLSLEEERSLSIPSSESEDNGRTRGRFQRPLCRAAQSERLLTHP
Sbjct: 2881 VAMFHRDAGADSDSDSDLSLEEERSLSIPSSESEDNGRTRGRFQRPLCRAAQSERLLTHP 2940
Query: 2941 KDVDGNDLLSYWPALGECEAAPCALQTWGSERRLGLDTSKDAANNNQPDPALTSGDETSL 3000
KDVDGNDLLSYWPALGECEAAPCALQTWGSERRLGLDTSKDAANNNQPDPALTSGDETSL
Sbjct: 2941 KDVDGNDLLSYWPALGECEAAPCALQTWGSERRLGLDTSKDAANNNQPDPALTSGDETSL 3000
Query: 3001 GRAQRQRKGILKNRLQYPLVPQTRGAPELSWCRAATLGHRAVPAASYGRIYAGGGTGSLS 3060
GRAQRQRKGILKNRLQYPLVPQTRGAPELSWCRAATLGHRAVPAASYGRIYAGGGTGSLS
Sbjct: 3001 GRAQRQRKGILKNRLQYPLVPQTRGAPELSWCRAATLGHRAVPAASYGRIYAGGGTGSLS 3060
Query: 3061 QPASRYSSREQLDLLLRRQLSRERLEEAPAPVLRPLSRPGSQECMDAAPGRLEPKDRGST 3120
QPASRYSSREQLDLLLRRQLSRERLEEAPAPVLRPLSRPGSQECMDAAPGRLEPKDRGST
Sbjct: 3061 QPASRYSSREQLDLLLRRQLSRERLEEAPAPVLRPLSRPGSQECMDAAPGRLEPKDRGST 3120
Query: 3121 LPRRQPPRDYPGAMAGRFGSRDALDLGAPREWLSTLPPPRRTRDLDPQPPPLPLSPQRQL 3180
LPRRQPPRDYPGAMAGRFGSRDALDLGAPREWLSTLPPPRRTRDLDPQPPPLPLSPQRQL
Sbjct: 3121 LPRRQPPRDYPGAMAGRFGSRDALDLGAPREWLSTLPPPRRTRDLDPQPPPLPLSPQRQL 3180
Query: 3181 SRDPLLPSRPLDSLSRSSNSREQLDQVPSRHPSREALGPLPQLLRAREDSVSGPSHGPST 3240
SRDPLLPSRPLDSLSRSSNSREQLDQVPSRHPSREALGPLPQLLRAREDSVSGPSHGPST
Sbjct: 3181 SRDPLLPSRPLDSLSRSSNSREQLDQVPSRHPSREALGPLPQLLRAREDSVSGPSHGPST 3240
Query: 3241 EQLDILSSILASFNSSALSSVQSSSTPLGPHTTATPSATASVLGPSTPRSATSHSISELS 3300
EQLDILSSILASFNSSALSSVQSSSTPLGPHTTATPSATASVLGPSTPRSATSHSISELS
Sbjct: 3241 EQLDILSSILASFNSSALSSVQSSSTPLGPHTTATPSATASVLGPSTPRSATSHSISELS 3300
Query: 3301 PDSEVPRSEGHS 3312
PDSEVPRSEGHS
Sbjct: 3301 PDSEVPRSEGHS 3312
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 2980 bits (7726), Expect = 0.0
Identities = 1535/2862 (53%), Positives = 1951/2862 (68%), Gaps = 104/2862 (3%)
Query: 243 PELDSAPRTARTAPASGS-APRESRTAPEPAPKRMRSRGLFRCRF--LPQRPGPRPPGLP 299
P + P + R G +P+ T PE P R RC+ L Q PG
Sbjct: 105 PAPEGCPWSCRLLGIGGHLSPQGKLTLPEEHPCLKAPR--LRCQSCKLAQAPG------- 155
Query: 300 ARPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGR 359
R R + R +R N PQF +YQ VPEN+ AGT V + A DPD GEAGR
Sbjct: 156 LRAGERSPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGR 215
Query: 360 LVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMV 419
L Y++ AL +SRS + FS+DP +G + TA LDRE+ H RVTAQDHG PR SA +
Sbjct: 216 LEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATL 275
Query: 420 AVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAAR 479
+ V D NDH PVFEQ +Y+E+LREN+E GY +L +RATDGDAPPNAN+ YR + +
Sbjct: 276 TILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLL--EGSG 333
Query: 480 AAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEN 539
+ + FEIDPRSG+I T G VDRE +ESY+L VEASDQG++PGPRS T V ++V D+N
Sbjct: 334 GSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDN 393
Query: 540 DNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLT 599
DNAPQFSEKRYV QVREDV P VLRVTA+DRDK +N +VHY+I+SGN+RG F +D+ T
Sbjct: 394 DNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT 453
Query: 600 GEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVS 659
G + VV+PLD+E +EY LR+RAQD GRPPLSN +GL ++QV+DIND+ PIFVSTPFQ +
Sbjct: 454 GALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQAT 513
Query: 660 VLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESV 719
VLE+ PLG+ V+H+QA+DAD G+NARLEY L GV D PF IN+ TGW+SV+ LDRE V
Sbjct: 514 VLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEV 573
Query: 720 EHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVT 779
+ Y FGVEARDHG+P L+ASASV+VTVLDVNDN P FT EY +RLNEDAAVGTSVV+V+
Sbjct: 574 DFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVS 633
Query: 780 AVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALH 839
AVDRDA+S I+YQIT GNTRNRF+I++Q G GLV+LALPLDYK ER + L +TASD
Sbjct: 634 AVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQ 693
Query: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
D + +N+TDANTHRPVFQS+HY+V+VNEDRP G+T+V+ISA+D+D GENARITY +ED
Sbjct: 694 DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED 753
Query: 900 NLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAP 959
++PQFRIDAD+GA+T QA LDYEDQV+YTLAITARDNGIPQK+DTTY+E++VNDVNDNAP
Sbjct: 754 SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAP 813
Query: 960 QFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIV 1019
QF+ Y G V ED PPFTSVLQISATDRD+ NGRV YTFQ G+DGDGDF +E TSGIV
Sbjct: 814 QFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIV 873
Query: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
RT+RRLDRE V+ Y L AYAVD+G+PP RTP+ + V V DVNDN PVF +EF+V V+EN
Sbjct: 874 RTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEEN 933
Query: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV 1139
S +G VA++TA DPDEG NA IMYQIVEGNIPE+FQ+DIFSGELTAL+DLDYE R EYV
Sbjct: 934 SPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYV 993
Query: 1140 IVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYD 1199
+V+QATSAPLVSRATVHVRL+D+NDN PVL NF+ILFNNYV+NRS +FP G IGR+PA+D
Sbjct: 994 LVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHD 1053
Query: 1200 PDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQC 1259
PD+SD L YSFERGNEL L+++N ++GEL+LSR LDNNRPL A M V V+DG+HSVTAQC
Sbjct: 1054 PDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQC 1113
Query: 1260 VLRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDT 1319
LRV IIT+E+L +S+T+RLE+M ERFLSPLLG F++ VAA LATP + V +FN+Q DT
Sbjct: 1114 ALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDT 1173
Query: 1320 DV-GGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNV 1378
D GG +LNVS S P G G G P+ SE+LQE+LY+ R+ L A S VLPFDDN+
Sbjct: 1174 DAPGGHILNVSLSVGQPPGPGGGP--PFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNI 1231
Query: 1379 CLREPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDL 1438
CLREPCENYM+CVSVLRFDSSAPF+AS+S LFRPI P+ GLRCRCPPGFTGD+CETE+DL
Sbjct: 1232 CLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDL 1291
Query: 1439 CYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGF 1498
CYS PC G C REGGYTC+CR +TGE CE+ +GRC PGVC+NGGTC + GGF
Sbjct: 1292 CYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGF 1351
Query: 1499 RCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRL 1558
+C CP+G FE P C+V RSFP SF+ FRGLRQRFH TL+LSFAT ++ GLL YNGR
Sbjct: 1352 KCDCPSGD-FEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRF 1410
Query: 1559 NEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGG 1618
NEKHDF+ALE++ QV+LT+S GES T VSP VPGG+SDGQWHTV L+YYNKP G
Sbjct: 1411 NEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGL 1470
Query: 1619 AQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPN 1678
QGPS+ KVAV++VD CD VAL+FG+ +GNYSCAA G Q SKKSLDLTGPLLLGGVP+
Sbjct: 1471 PQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPD 1530
Query: 1679 LPENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCS 1738
LPE+FPV + F+GCMR+L +D R +DMA F+ANNGT+ GC AK + CDS C N G C
Sbjct: 1531 LPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCV 1590
Query: 1739 ERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRAT 1798
+W +FSC+CP+GFGGK C MA+P HF G+ ++W+ G + +S PWYL L FRTR
Sbjct: 1591 NQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWH-GLSLPISQPWYLSLMFRTRQA 1649
Query: 1799 QGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEE 1858
GVL+Q ST+ QL G + ++V +AS L L+ +DG WH +L L
Sbjct: 1650 DGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQLAL--G 1707
Query: 1859 PGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQG 1918
G GH +L S D+ + +G L GL + + VGG+ PG A +G GC+QG
Sbjct: 1708 ASGGPGHAIL--SFDYGQQRAEGNLGPRLHGLHLSNITVGGI-PGPAGGVARGFRGCLQG 1764
Query: 1919 VWLGSTPSGSPALLPPSH--RVNAEPGCVVTNACASGPCPPHADCRDLWQTFSCTCQPGY 1976
V + TP G + L PSH +N E GC + + C S PCP ++ C + W ++SC+C PGY
Sbjct: 1765 VRVSDTPEGVNS-LDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGY 1823
Query: 1977 YGPGCVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPT 2036
YG C + C LNPC++Q C P APHGYTC+C Y G +CE R+DQ CPRGWWG PT
Sbjct: 1824 YGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGPYCETRIDQPCPRGWWGHPT 1883
Query: 2037 CGPCNCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQC 2096
CGPCNCDV KGFDP+CNKT+G+CHCKE HYRP GS +CL CDCYP GS SR C P GQC
Sbjct: 1884 CGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCDPEDGQC 1943
Query: 2097 PCRPGALGRQCNSCDSPFAEVTASGCRVLYDACPKSLRSGVWWPQTKFGVLATVPCPRGA 2156
PC+PG +GRQC+ CD+PFAEVT +GC V YD+CP+++ +G+WWP+T+FG+ A PCP+G+
Sbjct: 1944 PCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGS 2003
Query: 2157 LGAAVRLCDEAQGWLEPDLFNCTSPAFRELSLLLDGLELNKTALDTMEAKKLAQRLREVT 2216
G AVR CDE +GWL P+LFNCTS F EL + L+ N++ LD+ +++LA LR T
Sbjct: 2004 FGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQLALLLRNAT 2063
Query: 2217 GHTDHYFSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLWAGSALLAPETGDL 2276
HT YF DV+V +L LLA ES Q+GFGL+ATQD HF ENLL GSALL
Sbjct: 2064 QHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSALLDTANKRH 2123
Query: 2277 WAALGQRAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPNIMLSIDRMEHPSS 2336
W + Q G+A L++H E YA+ LA+NM TYL+P +VTPNI++S+ R++ +
Sbjct: 2124 WELIQQT----EGGTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNF 2179
Query: 2337 PRGARRYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSSIENSTTSSVVPPP 2396
+ PRY + RG+ D T V+LP R +P V P
Sbjct: 2180 --AGAKLPRYEA--LRGEQPPDLETTVILPESVFRETPPVVRPAGPGEAQEPEELARRQR 2235
Query: 2397 APPEPEPGISIIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVVSVAVFHGRNFLR 2456
PE G ++ +++YRTL GLLP + ++R R+P+ P++N+PVVS++V L
Sbjct: 2236 RHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVVSISVHDDEELLP 2295
Query: 2457 GILESPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSHARCRCSR 2516
L+ P++++FRLL+T R+K ICV W+ L G W+AR CE+V RN SH C+C+
Sbjct: 2296 RALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNH 2355
Query: 2517 TGTFGVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNVRGIHA 2576
+F VLMD S RE G++ L T+V + V++AAL+LT L LR L+SN GI
Sbjct: 2356 MTSFAVLMDVSRRE--NGEILPLKTLTYVALGVTLAALLLTFFFLTLLRILRSNQHGIRR 2413
Query: 2577 NVAAALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQVEPRN 2636
N+ AALG+A+L+FLLGI++ CT +AILLH+ +L TF+W ++ LHLYR E R+
Sbjct: 2414 NLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALHLYRALTEVRD 2473
Query: 2637 VDRGAMRFYHALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFAGPVVLVIVM 2696
V+ G MRFY+ LGWGVPA + GLAVGLDPEGYGNPDFCW+S+++ LIWSFAGPV + M
Sbjct: 2474 VNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSM 2533
Query: 2697 NGTMFLLAARTSCSTGQREA--KKTSALTLRSSFLLLLLVSASWLFGLLAVNHSILAFHY 2754
+ +++LAAR SC+ QR+ KK L+ SF +LLL+SA+WL LL+VN L FHY
Sbjct: 2534 SVFLYILAARASCA-AQRQGFEKKGPVSGLQPSFAVLLLLSATWLLALLSVNSDTLLFHY 2592
Query: 2755 LHAGLCGLQGLAVLLLFCVLNADARAAWMPACLGRKAAPEEARPAPGLGPGAYNNTALFE 2814
L A +QG + L + VL+ + R A AC RK +P+ A +YN + +
Sbjct: 2593 LFATCNCIQGPFIFLSYVVLSKEVRKALKLAC-SRKPSPDPALTTKSTLTSSYNCPSPYA 2651
Query: 2815 ESGLIRITLGASTVSSVSSARSGRTQDQDSQRGRSYLRDNVLVRHGSAADHTDHSLQAHA 2874
+ L + G S S S++RSG++Q SY+ L+R SA +
Sbjct: 2652 DGRLYQ-PYGDSAGSLHSTSRSGKSQP-------SYI--PFLLREESAL-NPGQGPPGLG 2700
Query: 2875 GPTDLDVAMFHRDAGADSDSDSDLSLEEERSLSIPSSESEDNGRTRGRFQRPLCRAAQ-- 2932
P L + + D+DSDSDLSLE+++S S S+ S D+ + +
Sbjct: 2701 DPGSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQG 2760
Query: 2933 --------SERLLTH--PKDVDGNDLLSYWPALGECEAAPCALQTWGSERRLGLDTSKDA 2982
+ERL H PKD + WP +G+ T+K++
Sbjct: 2761 WDSLLGPGAERLPLHSTPKDGGPGPGKAPWPG------------DFGT-------TAKES 2801
Query: 2983 ANNNQPDPAL-TSGDETSL--------GRAQRQRKGILKNRLQYPLVPQTRGAPE--LSW 3031
+ N P+ L +GD S G + + KGILK + P + + L
Sbjct: 2802 SGNGAPEERLRENGDALSREGSLGPLPGSSAQPHKGILKKKC-LPTISEKSSLLRLPLEQ 2860
Query: 3032 CRAATLGHRAVPAASYGRIYAGGGTGSLSQPASRYSSREQLD 3073
C ++ G A G G +P R S +EQL+
Sbjct: 2861 CTGSSRGSSA---------SEGSRGGPPPRPPPRQSLQEQLN 2893
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 2815 bits (7298), Expect = 0.0
Identities = 1482/2927 (50%), Positives = 1924/2927 (65%), Gaps = 143/2927 (4%)
Query: 165 SGNSSPLPSDF-LIRHHGPKPVSSQRNA-----GTGSRKRV-GT-ARCCGELW------- 209
SG PLP L+ P +S + A G G+R R+ GT AR CG L
Sbjct: 80 SGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGC 139
Query: 210 ATGSKGQGERATTSGAERTAPRRN--------CLPGASGSGPELDSAPRTARTAPASGSA 261
A TT A R PR CLP L A R A A G A
Sbjct: 140 AAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVRLRLLCALRRAAGAVRVGLA 199
Query: 262 PRESRTAPEPAPKRMRSRGLFRCRFLPQRPGPRPPGLPARPEARKVTSANRARFRRAANR 321
E+ TA P+ P P PP P PEAR A RAR +
Sbjct: 200 -LEAATAGTPSAS----------------PSPSPPLPPNLPEAR-AGPARRARRGTSGRG 241
Query: 322 HPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQ 381
+FP NYQ + ENE AGT +L++ A GE R+ Y + L + RS F ID
Sbjct: 242 SLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
Query: 382 SGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
+G + T + LDRE+ E H LRV A D+ +P SATT + V V D NDHSPVFEQ++YRE
Sbjct: 302 TGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRER 361
Query: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
+REN+E GY +L +RA+D D+P NANLRYR +G A F+++ SG++ST +
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRYRVLG------GAWDVFQLNESSGVVSTRAVL 415
Query: 502 DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561
DRE Y+L+VEA+DQG+ PGP SAT V+I V DENDN PQFSE+ YV QV EDV +
Sbjct: 416 DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLN 475
Query: 562 TVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIR 621
T VLRV ATDRD+ N +HY+I+SGN G F + SL+G + V+ PLDFE ++Y+L I+
Sbjct: 476 TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
Query: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
AQD GRPPL N++G+ S+QV+D+ND+ PIFVS+PFQ +VLEN PLG+ V+HIQAVDAD G
Sbjct: 536 AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
Query: 682 ENARLEYSLTGVA-----------------PDTPFVINSATGWVSVSGPLDRESVEHYFF 724
ENARL Y L A PD PF I++++GW++V LDRE VEHY F
Sbjct: 596 ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSF 655
Query: 725 GVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD 784
GVEA DHGSPP+S+S SV++TVLDVNDN P FT Y LRLNEDAAVG+SV+++ A DRD
Sbjct: 656 GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
Query: 785 ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYV 844
ANS I+YQ+TGGNTRNRFA+S+Q G GL+TLALPLDYKQE+ + L +TASD +V
Sbjct: 716 ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHV 775
Query: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQF 904
IN+TDANTHRPVFQS+HY+VSV+EDRP+G++I +SA+D+D GENARITY+++D +PQF
Sbjct: 776 LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQF 835
Query: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVAS 964
RID DSG + LDYE+QV YTL I A+DNGIPQK+DTT +E+++ D NDNAPQF+
Sbjct: 836 RIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWD 895
Query: 965 HYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRR 1024
Y G + EDAPP TS+LQ+SATDRD+ NGR+ YTFQ G+DGDGDF IEPTSG++RT RR
Sbjct: 896 FYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRR 955
Query: 1025 LDREAVSVYELTAYAVDRGVP-PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVG 1083
LDRE V+VY L A AVDRG P PL V IQV + D+NDNAP+F +E E+ V+EN+ VG
Sbjct: 956 LDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG 1015
Query: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143
SVVA+I A DPDEGPNA IMYQIVEG++ FQ+D+ +G+L A+++LD+E R+EYV+VVQ
Sbjct: 1016 SVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQ 1075
Query: 1144 ATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVS 1203
ATSAPLVSRATVH+ LVDQNDN PVL +FQILFNNYV+N+S++FP+G+IG IPA+DPDVS
Sbjct: 1076 ATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVS 1135
Query: 1204 DHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRV 1263
D L Y+F +GNEL+LL+++ +GEL+LSR LDNNRPL A M V+V+DG+HSVTA C LRV
Sbjct: 1136 DSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRV 1195
Query: 1264 VIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTDVGG 1323
IIT+++L NS+TVRLENM QE+FLSPLL F+EGVAAVL+T +DVF+FN+QNDTDV
Sbjct: 1196 TIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSS 1255
Query: 1324 TVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCLREP 1383
+LNV+FSAL P G G +F SE+LQEQ+Y+ R L S VLPFDDN+CLREP
Sbjct: 1256 NILNVTFSALLP----GGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREP 1311
Query: 1384 CENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDLCYSNP 1443
CENYMKCVSVLRFDSSAPFL+S + LFRPI PI GLRCRCPPGFTGD+CETE+DLCYS+P
Sbjct: 1312 CENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDP 1371
Query: 1444 CRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRCQCP 1503
C G C REGGYTC C FTGE CE+D +GRC GVC+NGGTC + GGF C CP
Sbjct: 1372 CGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCP 1431
Query: 1504 AGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHD 1563
G +E P CEV RSFPP SFV FRGLRQRFH T+SL+FAT +++GLL YNGR NEKHD
Sbjct: 1432 P-GEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHD 1490
Query: 1564 FLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPS 1623
F+ALE+V QV+LT+S GE+ T V+P VP G+SDG+WH+V ++YYNKP LG GPS
Sbjct: 1491 FIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPS 1550
Query: 1624 KDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENF 1683
+K+AV++VDDCD +A++FG +IGNYSCAA G QT SKKSLDLTGPLLLGGVPNLPE+F
Sbjct: 1551 GEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDF 1610
Query: 1684 PVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGS 1743
PV ++ F+GCMR+L +DG+ VDMA F+ANNGT GC A+ +FCD C+N G C RW
Sbjct: 1611 PVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNM 1670
Query: 1744 FSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLM 1803
+ C+CP+ FGGK+C+ M HP F G +SW+ ++ +SVPWYLGL FRTR VLM
Sbjct: 1671 YLCECPLRFGGKNCEQAMPHPQLFSGESVVSWS-DLNIIISVPWYLGLMFRTRKEDSVLM 1729
Query: 1804 QVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRR 1863
+ +G ++ Q+ L V+ G ++L + V+DG WH L +EL+
Sbjct: 1730 EATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSE 1789
Query: 1864 GHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQGVWLGS 1923
H++ ++LD+ + Q+ +G L GL V+ + VGG +G GC+QGV +G
Sbjct: 1790 MKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKV-SVRRGFRGCMQGVRMGG 1848
Query: 1924 TPSGSPAL-LPPSHRVNAEPGCVVTNACASGPCPPHADCRDLWQTFSCTCQPGYYGPGCV 1982
TP+ L + + +V + GC V + C S PCPP++ C D W+ +SC C GY G CV
Sbjct: 1849 TPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCV 1908
Query: 1983 DACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPTCGPCNC 2042
DAC LNPC+N G+C PG+P GY C+C ++G +CE+++D CPRGWWG+P CGPC+C
Sbjct: 1909 DACHLNPCENMGACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHC 1968
Query: 2043 DVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQCPCRPGA 2102
V KGFDP+CNKTNGQC CKE +Y+ D+CLPCDC+P GS SR+C +GQC C+PG
Sbjct: 1969 AVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGV 2028
Query: 2103 LGRQCNSCDSPFAEVTASGCRVLYDACPKSLRSGVWWPQTKFGVLATVPCPRGALGAAVR 2162
+GRQCN CD+PFAEVT GC V+Y+ CPK+ +G+WWPQTKFG A VPCP+G++G AVR
Sbjct: 2029 IGRQCNRCDNPFAEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVR 2088
Query: 2163 LCDEAQGWLEPDLFNCTSPAFRELSLLLDGLELNKTALDTMEAKKLAQRLREVTGHTDHY 2222
C +GWL P+LFNCT+ +F +L + + L N+T +D A +L + LR T HT
Sbjct: 2089 HCSGEKGWLPPELFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTL 2148
Query: 2223 FSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLWAGSALLAPETGDLWAALGQ 2282
F DVR +LL H+L ES QQGF L ATQDA F+E+++ +GSALLAP T W + Q
Sbjct: 2149 FGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQI-Q 2207
Query: 2283 RAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPNIMLSIDRMEHPSSPRGAR- 2341
R+ G G+A L+R LE Y + +ARN+ TYL P +VT N++L++D + + GAR
Sbjct: 2208 RSEG---GTAQLLRRLEGYFSNVARNVRRTYLRPFVIVTANMILAVDIFD-KFNFTGARV 2263
Query: 2342 -RYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSSIENSTTSSVVPPPAPPE 2400
R+ H R + + V P+ RP + P TT P E
Sbjct: 2264 PRFDTIHEEFPR-----ELESSVSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTE 2318
Query: 2401 PEPGIS-------------IIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVVSVA 2447
E IS + ++++YRTLG LLP ++ +RR RLP P++N+P+VS
Sbjct: 2319 REAPISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTL 2378
Query: 2448 VFHGRNFLRGILESPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNG 2507
V+ L LE P+ +EF LL+ R+K +CV W+ G W+AR CEL+ RN
Sbjct: 2379 VYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNR 2438
Query: 2508 SHARCRCSRTGTFGVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSL 2567
+H C+CS T +F VLMD S RE G++ L + T+ V++S+AAL++ +L +R L
Sbjct: 2439 THVACQCSHTASFAVLMDISRRE--NGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRML 2496
Query: 2568 KSNVRGIHANVAAALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHL 2627
+SN+ IH ++A AL +++L+F++GI++T N +CT VAILLHY ++STFAW V+ LH+
Sbjct: 2497 RSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHV 2556
Query: 2628 YRMQVEPRNVDRGAMRFYHALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFA 2687
YRM E RN+D G MRFY+ +GWG+PA++ GLAVGLDP+GYGNPDFCW+S+ + LIWSFA
Sbjct: 2557 YRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFA 2616
Query: 2688 GPVVLVIVMNGTMFLLAARTSCSTGQR-EAKKTSALTLRSSFLLLLLVSASWLFGLLAVN 2746
GP+ VI++N +L+A+ SC KK LR++FLLLLL+SA+WL GLLAVN
Sbjct: 2617 GPIGAVIIINTVTSVLSAKVSCQRKHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVN 2676
Query: 2747 HSILAFHYLHAGLCGLQGLAVLLLFCVLNADARAAWMPACLGRKAAPEEARP--APGLGP 2804
L+FHYL A GLQG VLL CVLN + R GRK E++ A L
Sbjct: 2677 RDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTR 2736
Query: 2805 GAYNNTALFEESGLIRITLGASTVSSVSSARSGRTQDQDSQRGRSYLRDNVLVRHGSAAD 2864
NT + ++R LG ST S S R Q G LVR
Sbjct: 2737 SLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQKLGVSSG--------LVR------ 2782
Query: 2865 HTDHSLQAHAGPTDLDVAMFHRDA----GADSDSDSDLSLEEERS--LSIPSSESEDNGR 2918
+H P D ++ R G DSDSDS+LSL+E+ S S SS+SED+G
Sbjct: 2783 ------GSHGEP---DASLMPRSCKDPPGHDSDSDSELSLDEQSSSYASSHSSDSEDDGV 2833
Query: 2919 TRGRFQRPLCRAAQSERLLTHPKDVDGNDLLSYWP--ALGECEAA-PCALQTWGSERRLG 2975
P A S T D N + + WP +L E ++ P E ++
Sbjct: 2834 GAEEKWDPARGAVHS----TPKGDAVANHVPAGWPDQSLAESDSEDPSGKPRLKVETKVS 2889
Query: 2976 LDTSKDAANNNQPD--PALTSGDETSLGRAQ--RQRKGILKNRLQYP 3018
++ ++ +++ + P SG L +Q QRKGILKN++ YP
Sbjct: 2890 VELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYP 2936
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 598 bits (1543), Expect = e-170
Identities = 516/1810 (28%), Positives = 812/1810 (44%), Gaps = 206/1810 (11%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P+F Q + VPEN G V RV D D G YS+ SL F+I+P +
Sbjct: 2771 PRFSQI-FSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM----DASLP-FTINPST 2824
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
G I + L+RE +R+ +RV+A D G + +T V + V D ND++P F + Y
Sbjct: 2825 GDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRFSRTSYYLDC 2881
Query: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
E E G + Q+ ATD D N + Y F+ + + F I+ +G I +
Sbjct: 2882 PELTEIGSKVTQVFATDPDEGSNGQVFY-FI------KSQSEYFRINATTGEIFNKQILK 2934
Query: 503 REHMESYE--------LVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
+++ + +V +SD+G+ P S T V I ++D NDNAPQF + +Y V
Sbjct: 2935 YQNVTGFSNVNINRHSFIVTSSDRGK-PSLISETT-VTINIVDSNDNAPQFLKSKYFTPV 2992
Query: 555 REDVRPHTVVLRVTATDRDKD--ANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
++V+ T ++RVTA D DKD N V Y I + N G F +D+ TG I V + L +
Sbjct: 2993 TKNVKVGTKLIRVTAID-DKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDL 3051
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
+ + + + A+D G PPLS+ + I V + N H P F + ++ E+ +G V
Sbjct: 3052 NQNFFITVTAKDKGNPPLSSQATV-HITVTEENYHTPEFSQSHMSATIPESHSIGSIVRT 3110
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG 732
+ A D D N ++YS++ + F INS+TG ++++ LD E + + + A D G
Sbjct: 3111 VSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGG 3170
Query: 733 SPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAIS 790
+ SVTV V+DVNDN P F +Y + E+A GT+V+ + A D D+ N+ I+
Sbjct: 3171 WVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIA 3230
Query: 791 YQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHC---YVHIN 847
Y + ++ + F I GV +T LD++ ++ + L + A + + C V+I
Sbjct: 3231 YTVQSSDS-DLFVIDPNTGV--ITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQ 3287
Query: 848 ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FR 905
+ N + P F S Y ++E P G+ + + ASD D+G + + YL+ N + F+
Sbjct: 3288 LKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQ 3347
Query: 906 IDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKA--DTTYVEVMVNDVNDNAPQFVA 963
I+ +G I + LD E + +L + A++ G + A D V V V D ND P F
Sbjct: 3348 INKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTL 3406
Query: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHAN-GRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
+ Y+ +SE P T V +SA D D+ + R Y +G + +G F+I P +G +
Sbjct: 3407 NIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNE-NGAFSINPQTGQITVT 3465
Query: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
LDRE + +Y L+ AVD G P S+ V ++D+NDN P+ E E V EN
Sbjct: 3466 AELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGE--VMENKRP 3523
Query: 1083 GSVVAQITAVDPDEGPN--AHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV- 1139
G++V + + DPD PN Y + G F + +G L+ ++D E ++
Sbjct: 3524 GTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFYL 3582
Query: 1140 -IVVQATSAP-LVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPA 1197
+V + + P + S TVH+ ++DQNDN +I N Y + FP GI+G +
Sbjct: 3583 SVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYY----GNLFPGGILGSVKP 3638
Query: 1198 YDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHS-VT 1256
DPDV D S G + T R D L V DG+HS VT
Sbjct: 3639 QDPDVLDSFHCSLTSGVTSLFSIPGGTCDLNSQPRSTDGTFDLT----VLSNDGVHSTVT 3694
Query: 1257 AQCVLRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQ 1316
+ + + + NS+ +RL + FL+ FL ++ L V +++
Sbjct: 3695 SNIRVFFAGFSNATVDNSILLRLGVPTVKDFLTNHYLHFLRIASSQLTGLGTAVQLYSAY 3754
Query: 1317 NDTDVGGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDD 1376
+ + T L + + +F S +++ +R++ + S+ D
Sbjct: 3755 EENN--RTFLLAAVKRNHNQYVNPSGVATFFES---IKEILLRQSGVKVESV------DH 3803
Query: 1377 NVCLREPCENYMKCV------SVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGD 1430
+ C+ PC+N C+ SVL+ S P + A+ P+QP C+C PG+ G
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVAN---EPLQPFL---CKCLPGYAGS 3857
Query: 1431 FCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTC 1490
+CE ++D C +PC +GG C GG++C C FTG CE D C+ C+NG C
Sbjct: 3858 WCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERD--INECLQSPCKNGAIC 3915
Query: 1491 TDAPNGGFRCQCPAG-------------------------------------GAFEGPRC 1513
+ P G F C C G G F G C
Sbjct: 3916 QNFP-GSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVF-GKHC 3973
Query: 1514 EVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYN--GRLNEKHDFLALELVA 1571
E+ + F S++ F L + + + FAT++ LL YN + ++ +FLALE+
Sbjct: 3974 ELNSYGFEELSYMEFPSLDPNNNY-IYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAE 4032
Query: 1572 GQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLS 1631
++R +Y+ G + T +SDG +HTV R A L+
Sbjct: 4033 ERLRFSYNLGSGTYKL--TTMKKVSDGHFHTVIAR----------------RAGMAASLT 4074
Query: 1632 VDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDL-TGPLLLGGV----PNLPENFPVS 1686
VD C E G C + V S +LD+ + +GG+ P L V
Sbjct: 4075 VDSCSE------NQEPG--YCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVE 4126
Query: 1687 HKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSC 1746
DF+GC+ + ++GR ++ + +A G + C C PC++ G C + W C
Sbjct: 4127 SHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSPCQHGGTCMDYWSWQQC 4186
Query: 1747 DCPVGFGGKDCQ--LTMAHPHHFRGNGTLSWNFGSDM------------AVSVPW---YL 1789
C G GK C+ +T G G L ++ + A+ P+ L
Sbjct: 4187 HCKEGLTGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNSL 4246
Query: 1790 GLAFRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWH 1849
+ FRTR+ GVL+ +Q + T + ++ G + T G + +V V+DG WH
Sbjct: 4247 EVKFRTRSENGVLIHIQESSNYTTV-KIKNGKVYFTSDAGIAGKVERNIPEVYVADGHWH 4305
Query: 1850 DLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAP 1909
+ G+ G ++S+D +D + + GL V + +GG+PP A
Sbjct: 4306 TFLI-------GKNG-TATVLSVDRIYNRDIIHPTQDFGGLDVLTISLGGIPPNQAHRDA 4357
Query: 1910 Q--GLVGCIQGVWLG--STP-SGSPALLPPSHR-VNAEPGCVVTNACASGPCPPHADCRD 1963
Q G GCI +W G S P SG +L S + + GC N CAS PC C +
Sbjct: 4358 QTAGFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCIN 4417
Query: 1964 LWQTFSCTCQPGYYGPGCVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCE--- 2020
W + C PG C +PCQN GSC PG G+TC C + G CE
Sbjct: 4418 QWYAYRCV-PPG--------DCASHPCQNGGSCE--PGLHSGFTCSCPDSHTGRTCEMVV 4466
Query: 2021 HRMDQQCPRG 2030
+ CP+G
Sbjct: 4467 ACLGVLCPQG 4476
Score = 443 bits (1139), Expect = e-123
Identities = 321/952 (33%), Positives = 472/952 (49%), Gaps = 55/952 (5%)
Query: 323 PQFPQ-YNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQ 381
P F Q Y V EN GT +L + A D D G+ G + +SL R F +DP
Sbjct: 580 PVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDR--RSFRLDPV 637
Query: 382 SGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
SG + T ++LDRE + L V A D GSP S+ + V++ D ND+SPVF QY
Sbjct: 638 SGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAH 697
Query: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
++EN G I + ATD D N ++Y + A + F+++ +SG+IST +
Sbjct: 698 IKENEPGGSYITTVSATDPDLGTNGTVKY------SISAGDRSRFQVNAQSGVISTRMAL 751
Query: 502 DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561
DRE +Y+L + A+D G P A V ITVLD DN P FS+ Y V E+V
Sbjct: 752 DREEKTAYQLQIVATDGGNLQSPNQAIVT--ITVLDTQDNPPVFSQVAYSFVVFENVALG 809
Query: 562 TVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIR 621
V V+A+ D ++N + Y I +G+ +G FAI+ +TG++ +D E + Y L++
Sbjct: 810 YHVGSVSASTMDLNSN--ISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVV 867
Query: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
A ++ +T + +I V D+ND+ P F+ V+V+EN GHS+ +AVD D G
Sbjct: 868 ASGG---TVTGDT-MVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEG 923
Query: 682 ENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASAS 741
N + YSL P F IN G +S+ GPLD + Y + A D G P LS+S
Sbjct: 924 VNGMVLYSLK-QNPKNLFAINEKNGTISLLGPLDVHA-GSYQIEILASDMGVPQLSSSVI 981
Query: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTR 799
+TV V DVNDN P F Y + L+E V + V A D+D AN I+Y I GNT
Sbjct: 982 LTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTG 1041
Query: 800 NRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINIT----DANTHR 855
+ F I G + + + LD + + + L++ ASDRA+ + +N+T D N +R
Sbjct: 1042 DAFGIFPDGQLYIKS---ELDRELQDRYVLMVVASDRAV-EPLSATVNVTVILEDVNDNR 1097
Query: 856 PVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITL 915
P+F S +Y+ E++ GS + +SA D D G N + Y E P F + A SG IT
Sbjct: 1098 PLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITN 1157
Query: 916 QAPLDYED------QVTYTLAITARDNGIPQK-ADTTYVEVMVNDVNDNAPQFVASHYTG 968
D E ++ + A D GIPQ D V V + D+NDNAP+F+ Y
Sbjct: 1158 THQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQA 1217
Query: 969 LVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDRE 1028
+SE A T VL++SA+D D NG + Y+ G + + F I+ TSG V + +LD E
Sbjct: 1218 TISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNE-ERQFAIDSTSGQVTLIGKLDYE 1276
Query: 1029 AVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQ 1088
A Y L AVD G PL + ++ + + D NDN P FP V V EN +G +V+
Sbjct: 1277 ATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSS 1336
Query: 1089 ITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS-- 1146
+TA D D G NA + Y I N F + +G + LD+E + Y + + A
Sbjct: 1337 VTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQG 1396
Query: 1147 -APLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGI-IGRIPAYDP--DV 1202
P S +V + + D NDN P I F + V N P G + + A+DP D+
Sbjct: 1397 RPPRSSTMSVVIHVRDFNDNPPSFPPGDI-FKSIVEN----IPIGTSVISVTAHDPDADI 1451
Query: 1203 SDHLFYS----FERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
+ L Y+ RGN +++ G + + ++D + + V D
Sbjct: 1452 NGQLSYTIIQQMPRGNH---FTIDEVKGTIYTNAEIDREFANLFELTVKAND 1500
Score = 414 bits (1064), Expect = e-115
Identities = 295/926 (31%), Positives = 473/926 (51%), Gaps = 46/926 (4%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F +Y T + EN G+ VL D D G +L YS+A+ SL F++D ++
Sbjct: 1942 PIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIAS---GDSLGQFTVD-KN 1997
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
G+++ ALDRES + L V D + R ++T V++ + D ND+ P F +
Sbjct: 1998 GVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLT 2057
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
+ EN + + +ATD D+ PN+ + Y + P + F I G + +G
Sbjct: 2058 Y-IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK------FSIGTIDGEVRLTG 2110
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVR 559
+DRE + +Y L V A+D+GQ S++ V + VLD NDN P F++ Y ++ E+
Sbjct: 2111 ELDREEVSNYTLTVVATDKGQPS--LSSSTEVVVMVLDINDNNPIFAQALYKVEINENTL 2168
Query: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALR 619
T +++V A D D+ NG V Y I++GN+ F IDS+TG I V PLD E Y L
Sbjct: 2169 TGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLT 2228
Query: 620 IRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLEN-APLGHSVIHIQAVDA 678
++A D G P ++ T SI ++DIND +P+F +P+ V+V EN L +++ + A D
Sbjct: 2229 VQATDRGSTPRTD-TSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDD 2287
Query: 679 DHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSA 738
D G N++L Y L G D F + SA+G + V+ LDRE+ E + + A D GSP L+
Sbjct: 2288 DRGSNSKLSYVLFGGNEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDSGSPALTG 2346
Query: 739 SASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNT 798
+ ++ V V DVNDN P F K Y + EDA GT V+ V A D DA+ +I GGN
Sbjct: 2347 TGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGN- 2405
Query: 799 RNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD----RALHDHCYVHINITDANTH 854
++F I+ G ++T AL LD + + + LV+ SD L V + +TD N +
Sbjct: 2406 -SQFTINPSTG-QIITSAL-LDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDN 2462
Query: 855 RPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED-NLPQFRIDADSGAI 913
P FQ Y + GS + ++ +D D+G N+ + Y L N +F ID GAI
Sbjct: 2463 PPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAI 2522
Query: 914 TLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSED 973
PL+ +VT+++ + +D G K D+T V V + D P+ A T + E+
Sbjct: 2523 MAAGPLNGASEVTFSVHV--KDGGSFPKTDSTTVTVRFVNKAD-FPKVRAKEQTFMFPEN 2579
Query: 974 APPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVY 1033
P + V I+ + + Y +G G+ F I+ +G V + LD E + Y
Sbjct: 2580 QPVSSLVTTITGSSLRGEP---MSYYIASGNLGN-TFQIDQLTGQVSISQPLDFEKIQKY 2635
Query: 1034 ELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVD 1093
+ A D G PP + + + V DVNDNAP+F + F + EN + + ++A+D
Sbjct: 2636 VVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILEN-LSPRKILTVSAMD 2694
Query: 1094 PDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSRA 1153
D GPN + Y+IV GN+ F ++ +GE+ ++ LD E YV+ ++++ S++
Sbjct: 2695 KDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQS 2754
Query: 1154 T---VHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDVSDHLFYS 1209
T V + ++D+NDN+P F +F+ +V S P G + R+ D D+ +
Sbjct: 2755 TSVKVMINILDENDNAP---RFSQIFSAHVPENS---PLGYTVTRVTTSDEDIGINAISR 2808
Query: 1210 FERGNELQLLVVNQTSGELRLSRKLD 1235
+ + +N ++G++ +SR L+
Sbjct: 2809 YSIMDASLPFTINPSTGDIVISRPLN 2834
Score = 365 bits (938), Expect = e-100
Identities = 283/939 (30%), Positives = 453/939 (48%), Gaps = 70/939 (7%)
Query: 370 SRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDH 429
S S LF+I+ +G + T + +DRES+ + + S + T V V V D ND+
Sbjct: 75 SESHALFAINSSTGALYTTSTIDRESLPSDVINLVVL---SSAPTYPTEVRVLVRDLNDN 131
Query: 430 SPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNA--NLRYRFVGPPAARAAAAAAFE 487
+PVF T +E+ G ++ ATD D N + YR + R A F
Sbjct: 132 APVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRII-----RGNEAGRFR 186
Query: 488 ID---PRSG------LISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDE 538
+D SG L+S G +DRE Y+L+VE D+G+ R ++V++TV D
Sbjct: 187 LDITLNPSGEGAFLHLVSKGG-LDREVTPQYQLLVEVEDKGEP--KRRGYLQVNVTVQDI 243
Query: 539 NDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSL 598
NDN P F Y A V ED + VL+V A D D+ N + Y + + F +D
Sbjct: 244 NDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGT--PFQMDPE 301
Query: 599 TGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPI-----FVS 653
TG I V PLDFEA R+Y+L ++A D G P L+ A IQ++D+ND+ P+ F +
Sbjct: 302 TGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAE-ALIQLLDVNDNDPVVKFRYFPA 360
Query: 654 TPFQVSVLENAPLGHSVIHIQAVDADH-GENARLEYSLTGVAPDTPFVINSA----TGWV 708
T SV ENA +G V + DAD N + + G F + S+ +
Sbjct: 361 TSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLI 420
Query: 709 SVSGPLDRESVEHYFFGVEARD-HGSPP------LSASASVTVTVLDVNDNRPEFTMKEY 761
V+ LDRE + Y V D +G+PP S+ AS+ + V D+ND+ P F+ + Y
Sbjct: 421 KVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVY 480
Query: 762 HLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPL 819
+ L+E+A G+ V ++A D D+ N+ + Y I GN F IS G+ + L
Sbjct: 481 RVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGL 540
Query: 820 DYKQERYFKLVLTASDRALH---DHCYVHINITDANTHRPVF-QSAHYSVSVNEDRPMGS 875
D + L ++A D+ +H + + + + D N +PVF Q Y VSV E+ P G+
Sbjct: 541 DRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGT 600
Query: 876 TIVVISASDDDVGENARITYLL---EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAIT 932
++++ A+D D+G+N + + L E + FR+D SG ++ + LD E+Q Y+L +
Sbjct: 601 ELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVL 660
Query: 933 ARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA 992
A D G P ++ + V + D+NDN+P F Y + E+ P + + +SATD D
Sbjct: 661 ATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGT 720
Query: 993 NGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVS 1052
NG V+Y+ G+ F + SG++ T LDRE + Y+L A D G
Sbjct: 721 NGTVKYSISAGD--RSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAI 778
Query: 1053 IQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIP 1112
+ + V D DN PVF + V EN +G V ++A D N++I Y I G+
Sbjct: 779 VTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMD--LNSNISYLITTGDQK 836
Query: 1113 ELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSP----V 1168
+F ++ +G+LT +D E + Y + V A+ + V++ + D NDNSP
Sbjct: 837 GMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQA 896
Query: 1169 LNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD--VSDHLFYSFERGNELQLLVVNQTSG 1226
+ + ++ N+ + S I + A DPD V+ + YS ++ N L +N+ +G
Sbjct: 897 IESVNVV-ENWQAGHS-------IFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNG 947
Query: 1227 ELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
+ L LD + ++ G+ +++ +L V +
Sbjct: 948 TISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVYV 986
Score = 363 bits (933), Expect = 1e-99
Identities = 299/968 (30%), Positives = 457/968 (47%), Gaps = 56/968 (5%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P FP + + EN GT+V+ V A DPDA G+L Y++ M + F+ID
Sbjct: 1418 PSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNH--FTIDEVK 1475
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFEQAQYR 439
G I T A +DRE L V A D P R A V + V D ND+ P+F +Q
Sbjct: 1476 GTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFI-SQNA 1534
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
+ G + + A D D N + Y + F +D SG + +
Sbjct: 1535 LAADPSAVIGSVLTTIMAADPDEGANGEIEYEIIN------GDTDTFIVDRYSGDLRVAS 1588
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVR 559
+ + Y L+V A+D G P R +T +T++ + + P F++ +Y+ ++E
Sbjct: 1589 ALVPSQL-IYNLIVSATDLG--PERRKSTTE--LTIILQGLDGPVFTQPKYITILKEGEP 1643
Query: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGH-----FAIDSLTGEIQVVAPLDFEAER 614
T V+ + A + + V Y I+S F I TG IQ A LD E
Sbjct: 1644 IGTNVISIEAAS-PRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGA 1702
Query: 615 -EYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673
Y + + A + I + DIND+ P+F + ++V EN G ++ +
Sbjct: 1703 CLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQL 1762
Query: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGS 733
A+DAD G NA + Y++ A D+ F I+ +G + + LDRE Y V A D
Sbjct: 1763 TAMDADEGANALVTYTIISGADDS-FRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQ 1821
Query: 734 PPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISY 791
S+ + +TV DVND+ P+F+ Y + ED G+ V ++ A D D+ N I+Y
Sbjct: 1822 ---SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITY 1878
Query: 792 QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHINITD 850
+ + F ++ GV L LDY+ ++Y+ L + A D V+ NI D
Sbjct: 1879 IVNEDDEDGIFFLNPITGV--FNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILD 1936
Query: 851 ANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLPQFRIDA 908
N + P+F YS S+ E+ P+GST++V + +D D G N+++TY + D+L QF +D
Sbjct: 1937 VNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDK 1996
Query: 909 DSGAITLQAPLDYEDQVTYTLAITARDNGIPQK-----ADTTYVEVMVNDVNDNAPQFVA 963
+ G + + LD E Q Y L + D +PQ T V +++ DVNDN P F++
Sbjct: 1997 N-GVLKVLKALDRESQSFYNLVVQVHD--LPQIPASRFTSTAQVSIILLDVNDNPPTFLS 2053
Query: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR 1023
T + E+ P T V + ATD D+ N ++YT N F+I G VR
Sbjct: 2054 PKLT-YIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK--FSIGTIDGEVRLTG 2110
Query: 1024 RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVG 1083
LDRE VS Y LT A D+G P L + + VMV D+NDN P+F ++V + EN++ G
Sbjct: 2111 ELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTG 2170
Query: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143
+ + Q+ A D DEG N + Y IV GN + F++D +G +T LD E Y + VQ
Sbjct: 2171 TDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQ 2230
Query: 1144 AT---SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDP 1200
AT S P +TV + L+D ND PV N V T P I+ ++ A D
Sbjct: 2231 ATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVN--VPENLGTLPRTIL-QVVARDD 2287
Query: 1201 D--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD-GLHSVTA 1257
D + L Y GNE ++ SGEL +++ LD +++T TD G ++T
Sbjct: 2288 DRGSNSKLSYVLFGGNEDNAFTLS-ASGELGVTQSLDRETKERFVLMITATDSGSPALTG 2346
Query: 1258 QCVLRVVI 1265
+ V++
Sbjct: 2347 TGTINVIV 2354
Score = 362 bits (928), Expect = 4e-99
Identities = 308/1047 (29%), Positives = 474/1047 (45%), Gaps = 76/1047 (7%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ P F NY E + AG+ V +V A D D G G + YS M EL +I
Sbjct: 1095 DNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFE--MVQPDFELHAI- 1151
Query: 380 PQSGLIRTAAALDRESMERH------YLRVTAQDHGSPR-LSATTMVAVTVADRNDHSPV 432
SG I DRES+ R V A D G P+ L V V + D ND++P
Sbjct: 1152 --SGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPK 1209
Query: 433 FEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRS 492
F + Y+ T+ E+ +L++ A+D D N + Y + + F ID S
Sbjct: 1210 FLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSII-----KGNEERQFAIDSTS 1264
Query: 493 GLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA 552
G ++ G++D E +Y LV++A D G P ++T ++I +LDENDN P F +
Sbjct: 1265 GQVTLIGKLDYEATPAYSLVIQAVDSGTI--PLNSTCTLNIDILDENDNTPSFPKSTLFV 1322
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E++R +V VTATD D N ++Y+I N+ G F+I TG I + LDFE
Sbjct: 1323 DVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFET 1382
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
+ Y L I A+D GRPP S+ + I V D ND+ P F S++EN P+G SVI
Sbjct: 1383 QSLYKLNITAKDQGRPPRSSTMSVV-IHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVIS 1441
Query: 673 IQAVDADHGENARLEYSLTGVAP-DTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDH 731
+ A D D N +L Y++ P F I+ G + + +DRE + V+A D
Sbjct: 1442 VTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQ 1501
Query: 732 GSPPLS---ASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--AN 786
P + A +VT+ V D+NDN P F + + L + A +G+ + ++ A D D AN
Sbjct: 1502 AVPIETRRYALKNVTILVTDLNDNVPMF-ISQNALAADPSAVIGSVLTTIMAADPDEGAN 1560
Query: 787 SAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-CYVH 845
I Y+I G+T G + + + +P + + L+++A+D
Sbjct: 1561 GEIEYEIINGDTDTFIVDRYSGDLRVASALVP----SQLIYNLIVSATDLGPERRKSTTE 1616
Query: 846 INITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ-- 903
+ I PVF Y + E P+G+ ++ I A+ E Y++ +
Sbjct: 1617 LTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKT 1676
Query: 904 ----FRIDADSGAITLQAPLDYED-QVTYTLAITARDNGIP-QKADTTYVEVMVNDVNDN 957
F I +G I A LD E Y + + A + + VE+ + D+NDN
Sbjct: 1677 VGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDN 1736
Query: 958 APQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSG 1017
P F V E+ + ++Q++A D D AN V YT +G D F I+P SG
Sbjct: 1737 PPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISG--ADDSFRIDPESG 1794
Query: 1018 IVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVK 1077
+ RRLDRE S Y L A D G+ + + I + V DVND+ P F + +
Sbjct: 1795 DLIATRRLDRERRSKYSLLVRA-DDGLQ--SSDMRINITVSDVNDHTPKFSRPVYSFDIP 1851
Query: 1078 ENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQE 1137
E++I GS+VA I A D D G N I Y + E + +F ++ +G LDYE +Q
Sbjct: 1852 EDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQY 1911
Query: 1138 YVIVVQA-TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG---IIG 1193
Y++ V+A + V+ ++D NDN P+ + N+Y ++ + P G ++
Sbjct: 1912 YILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFS-----LNSYSTSLMENLPVGSTVLVF 1966
Query: 1194 RIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLH 1253
+ D ++ L YS G+ L V++ +G L++ + LD +++V V D L
Sbjct: 1967 NVTDADDGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQSFYNLVVQVHD-LP 2024
Query: 1254 SVTAQ---CVLRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDV 1310
+ A +V II ++ N T FLSP L E TP D
Sbjct: 2025 QIPASRFTSTAQVSIILLDVNDNPPT----------FLSPKLTYIPEN------TPI-DT 2067
Query: 1311 FIFNIQNDTDVGGTVLNVSFSALAPRG 1337
+F Q G + ++ L P G
Sbjct: 2068 VVFKAQATDPDSGPNSYIEYTLLNPLG 2094
Score = 359 bits (922), Expect = 2e-98
Identities = 284/962 (29%), Positives = 456/962 (47%), Gaps = 60/962 (6%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F Q V EN AG ++ + A DPD G G ++YSL LF+I+ ++
Sbjct: 891 PHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSL----KQNPKNLFAINEKN 946
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
G I LD + + + + A D G P+LS++ ++ V V D ND+SPVF+Q Y TL
Sbjct: 947 GTISLLGPLDVHAGS-YQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTL 1005
Query: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
E+ +++A+D D+ N + Y A AF I P G + +D
Sbjct: 1006 SESEPVNSRFFKVQASDKDSGANGEIAYTI-----AEGNTGDAFGIFP-DGQLYIKSELD 1059
Query: 503 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
RE + Y L+V ASD+ EP SATV V + + D NDN P F+ Y E+ R +
Sbjct: 1060 RELQDRYVLMVVASDRAVEP--LSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGS 1117
Query: 563 VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE------Y 616
V +V+A D+D NG V Y+ + F + +++GEI D E+ +
Sbjct: 1118 FVGKVSAVDKDFGPNGEVRYSFEM--VQPDFELHAISGEITNTHQFDRESLMRRRGTAVF 1175
Query: 617 ALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAV 676
+ + A D G P + + + DIND+ P F+ +Q ++ E+A V+ + A
Sbjct: 1176 SFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSAS 1235
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPL 736
D D G N + YS+ + F I+S +G V++ G LD E+ Y ++A D G+ PL
Sbjct: 1236 DVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPL 1295
Query: 737 SASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQIT 794
+++ ++ + +LD NDN P F + + E+ +G V SVTA D D+ N+ + Y IT
Sbjct: 1296 NSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSIT 1355
Query: 795 GGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDA 851
G N F+IS G + LA LD++ + +KL +TA D+ V I++ D
Sbjct: 1356 GTNNHGTFSISP--NTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDF 1413
Query: 852 NTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ---FRIDA 908
N + P F S+ E+ P+G++++ ++A D D N +++Y + +P+ F ID
Sbjct: 1414 NDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDE 1473
Query: 909 DSGAITLQAPLDYEDQVTYTLAITARDNGIP---QKADTTYVEVMVNDVNDNAPQFVASH 965
G I A +D E + L + A D +P ++ V ++V D+NDN P F++ +
Sbjct: 1474 VKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQN 1533
Query: 966 YTGLVSEDAPPFTSVL-QISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRR 1024
L ++ + SVL I A D D ANG ++Y NG+ F ++ SG +R
Sbjct: 1534 --ALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGD--TDTFIVDRYSGDLRVASA 1589
Query: 1025 LDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGS 1084
L + +Y L A D G ++ + +++Q + + PVF ++ +KE +G+
Sbjct: 1590 LVPSQL-IYNLIVSATDLGPERRKSTTELTIILQGL--DGPVFTQPKYITILKEGEPIGT 1646
Query: 1085 VVAQITAVDPDEGPNAHIMYQIV-----EGNIPELFQMDIFSGELTALIDLDYEARQ--- 1136
V I A P G A + Y IV E + LF + +G + LD E
Sbjct: 1647 NVISIEAASP-RGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLY 1705
Query: 1137 --EYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGR 1194
+ + ++T+ P RA V + L D NDN PV +L N D I +
Sbjct: 1706 LVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPT-DMLDLTVEENIGD---GSKIMQ 1761
Query: 1195 IPAYDPDVSDH--LFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGL 1252
+ A D D + + Y+ G + ++ SG+L +R+LD R S+LV DGL
Sbjct: 1762 LTAMDADEGANALVTYTIISGAD-DSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGL 1820
Query: 1253 HS 1254
S
Sbjct: 1821 QS 1822
Score = 350 bits (897), Expect = 2e-95
Identities = 302/1004 (30%), Positives = 465/1004 (46%), Gaps = 71/1004 (7%)
Query: 312 RARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSR 371
R R + P FP + E+ ++G V+ A D D G G + + ++
Sbjct: 122 RVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNG-VDHRSYRIIRGN 180
Query: 372 SLELFSID---PQSGL-----IRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTV 423
F +D SG + + LDRE ++ L V +D G P+ V VTV
Sbjct: 181 EAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTV 240
Query: 424 ADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAA 483
D ND+ PVF + Y+ + E+ G +LQ+ A D D NA++RYR
Sbjct: 241 QDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRL-------QDEG 293
Query: 484 AAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVH--ITVLDENDN 541
F++DP +GLI+ +D E Y L V+A D+G S T R I +LD NDN
Sbjct: 294 TPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVP----SLTGRAEALIQLLDVNDN 349
Query: 542 AP-----QFSEKRYVAQVREDVRPHTVVLRVTATDRDKD-ANGLVHYNIISGNSRGHFAI 595
P F A V E+ + TVV +T TD D ANG + I+ GN + HF +
Sbjct: 350 DPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEV 409
Query: 596 DSL----TGEIQVVAPLDFEAEREYALRIRAQD-AGRPP---LSNNTGLAS--IQVVDIN 645
S I+V + LD E Y L + D G PP + + +AS I V DIN
Sbjct: 410 QSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDIN 469
Query: 646 DHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSAT 705
DH P+F ++V++ E AP G V I A D D G NA L YS+ F I+ +
Sbjct: 470 DHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHS 529
Query: 706 GWVSV--SGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKE-YH 762
G V+ SG LDRE + ARD G P + A + VT+LDVND +P F+ E Y
Sbjct: 530 GLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYD 589
Query: 763 LRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGGNT-RNRFAISTQGGVGLVTLALPL 819
+ + E+A GT ++ + A D D N + + + T R F + G L T++ L
Sbjct: 590 VSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSG-RLSTIS-SL 647
Query: 820 DYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGST 876
D +++ ++ L++ A+D +++++ D N + PVF Y + E+ P GS
Sbjct: 648 DREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSY 707
Query: 877 IVVISASDDDVGENARITYLLE-DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARD 935
I +SA+D D+G N + Y + + +F+++A SG I+ + LD E++ Y L I A D
Sbjct: 708 ITTVSATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATD 767
Query: 936 NGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGR 995
G Q + V + V D DN P F Y+ +V E+ V +SA+ D ++N
Sbjct: 768 GGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN-- 825
Query: 996 VQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQV 1055
+ Y G D G F I +G + T +DRE S Y+L A V + +
Sbjct: 826 ISYLITTG-DQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTV---TGDTMVNI 881
Query: 1056 MVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELF 1115
V+D+NDN+P F V V EN G + Q AVDPDEG N ++Y + + N LF
Sbjct: 882 TVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLF 940
Query: 1116 QMDIFSGELTALIDLDYEARQEYV-IVVQATSAPLVSRATV-HVRLVDQNDNSPVLNNFQ 1173
++ +G ++ L LD A + I+ P +S + + V + D NDNSPV +
Sbjct: 941 AINEKNGTISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQL- 999
Query: 1174 ILFNNYVSNRSDTFP-SGIIGRIPAYDPD--VSDHLFYSFERGNELQLLVVNQTSGELRL 1230
+Y S++ P + ++ A D D + + Y+ GN + G+L +
Sbjct: 1000 ----SYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGI-FPDGQLYI 1054
Query: 1231 SRKLDNNRPLVASMLVTVTD-GLHSVTAQCVLRVVIITEELLAN 1273
+LD ++V +D + ++A + V +I E++ N
Sbjct: 1055 KSELDRELQDRYVLMVVASDRAVEPLSA--TVNVTVILEDVNDN 1096
Score = 350 bits (897), Expect = 2e-95
Identities = 287/974 (29%), Positives = 460/974 (47%), Gaps = 65/974 (6%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ +P F Q Y+ + EN GT +++V A D D G G++ Y ++N + + F ID
Sbjct: 2149 DNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRY---GIVNGNTNQEFRID 2205
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
+G I A LDRE ++L V A D GS + T+ V++ + D ND PVFE + Y
Sbjct: 2206 SVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYS 2265
Query: 440 ETLRENVEE-GYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTS 498
+ EN+ ILQ+ A D D N+ L Y G A +A SG + +
Sbjct: 2266 VNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSA------SGELGVT 2319
Query: 499 GRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDV 558
+DRE E + L++ A+D G + T +++ V D NDN P F+ K Y + ED
Sbjct: 2320 QSLDRETKERFVLMITATDSGSP--ALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDA 2377
Query: 559 RPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYAL 618
T VL V A+D D N ++ II GNS+ F I+ TG+I A LD E + Y L
Sbjct: 2378 PTGTDVLLVNASDADASKNAVI--RIIGGNSQ--FTINPSTGQIITSALLDRETKDNYTL 2433
Query: 619 RIRAQDAGRP-PLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVD 677
+ DAG P PLS++T + + V D+ND+ P F P+ + G V + D
Sbjct: 2434 VVVCSDAGSPEPLSSSTSVL-VTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTD 2492
Query: 678 ADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLS 737
AD G N+ L YSL+G F I+ G + +GPL+ S F V +D GS P +
Sbjct: 2493 ADIGPNSELHYSLSG-RNSEKFHIDPLRGAIMAAGPLNGAS--EVTFSVHVKDGGSFPKT 2549
Query: 738 ASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGN 797
S +VTV ++ D P+ KE E+ V + V ++T +SY I GN
Sbjct: 2550 DSTTVTVRFVNKAD-FPKVRAKEQTFMFPENQPVSSLVTTITGSSL-RGEPMSYYIASGN 2607
Query: 798 TRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTH 854
N F I G V+++ PLD+++ + + + + A D + + I + D N +
Sbjct: 2608 LGNTFQIDQL--TGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDN 2665
Query: 855 RPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDNLP-QFRIDADSGA 912
P+F+ + + E+ I+ +SA D D G N ++ Y ++ N+ F I+ +G
Sbjct: 2666 APIFKEDPFISEILENL-SPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGE 2724
Query: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972
I PLD E Y L I + D G P ++ + V + + D NDNAP+F + ++ V E
Sbjct: 2725 IRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRF-SQIFSAHVPE 2783
Query: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSV 1032
++P +V +++ +D D N +Y+ D FTI P++G + R L+RE
Sbjct: 2784 NSPLGYTVTRVTTSDEDIGINAISRYSIM---DASLPFTINPSTGDIVISRPLNREDTDR 2840
Query: 1033 YELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAV 1092
Y + A D G + + V D+NDNAP F + + E + +GS V Q+ A
Sbjct: 2841 YRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFAT 2897
Query: 1093 DPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYE----------ARQEYVIVV 1142
DPDEG N + Y I + E F+++ +GE+ L Y+ R +++
Sbjct: 2898 DPDEGSNGQVFYFIKSQS--EYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTS 2955
Query: 1143 QATSAP-LVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGI-IGRIPAYDP 1200
P L+S TV + +VD NDN+P Q L + Y + + G + R+ A D
Sbjct: 2956 SDRGKPSLISETTVTINIVDSNDNAP-----QFLKSKYFTPVTKNVKVGTKLIRVTAIDD 3010
Query: 1201 ---DVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVT---DGLHS 1254
++ + Y N L ++ +G + ++ L ++ L + +TVT G
Sbjct: 3011 KDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISD--LNQNFFITVTAKDKGNPP 3068
Query: 1255 VTAQCVLRVVIITE 1268
+++Q + + + E
Sbjct: 3069 LSSQATVHITVTEE 3082
Score = 146 bits (368), Expect = 4e-34
Identities = 120/416 (28%), Positives = 191/416 (45%), Gaps = 39/416 (9%)
Query: 855 RPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAIT 914
R VFQ V E++P G+ + I TY L ++ F I++ +GA+
Sbjct: 46 RQVFQ-------VLEEQPPGTLVGTIQTRPG-------FTYRLSESHALFAINSSTGALY 91
Query: 915 LQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDA 974
+ +D E + + + + T V V+V D+NDNAP F ED+
Sbjct: 92 TTSTIDRESLPSDVINLVVLSSA---PTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDS 148
Query: 975 PPFTSVLQISATDRDAHANG--RVQYTFQNGEDGDG---DFTIEPT--SGIVRTVRR--L 1025
V+ +ATD D +NG Y G + D T+ P+ + V + L
Sbjct: 149 SSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGL 208
Query: 1026 DREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSV 1085
DRE Y+L D+G P R + + V VQD+NDN PVF + ++ V E+++VGS
Sbjct: 209 DREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSS 268
Query: 1086 VAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT 1145
V Q+ A D DEG NA I Y++ + P FQMD +G +T LD+EAR++Y + VQA
Sbjct: 269 VLQVAAADADEGTNADIRYRLQDEGTP--FQMDPETGLITVREPLDFEARRQYSLTVQAM 326
Query: 1146 S---APLVSRATVHVRLVDQNDNSPVLN-NFQILFNNYVSNRSDTFPSGIIGRIPAYD-- 1199
L RA ++L+D NDN PV+ + + Y S + ++ + D
Sbjct: 327 DRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDAD 386
Query: 1200 -PDVSDHLFYSFERGNELQLLVVNQTS----GELRLSRKLDNNRPLVASMLVTVTD 1250
P + ++ GNE + V + ++++ LD R ++ V+V+D
Sbjct: 387 SPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSD 442
Score = 65.9 bits (159), Expect = 7e-10
Identities = 47/158 (29%), Positives = 67/158 (42%), Gaps = 22/158 (13%)
Query: 1966 QTFSCTCQPGYYGPGC---VDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHR 2022
Q F C C PGY G C +D CL +PC + G+C +L G G++C C G+ G CE
Sbjct: 3844 QPFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVG---GFSCSCPDGFTGRACERD 3900
Query: 2023 MDQQCPRGWWGSPTCGPC-NCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYP 2081
++ +C + PC N + + F + N C CK + S C+C P
Sbjct: 3901 IN-ECLQ--------SPCKNGAICQNFPGSFN-----CVCKTGYTGKMCESSVNYCECNP 3946
Query: 2082 -VGSTSRSCAPHSGQCPCRPGALGRQCNSCDSPFAEVT 2118
S S C C G G+ C F E++
Sbjct: 3947 CFNGGSCQSGVDSYYCHCPFGVFGKHCELNSYGFEELS 3984
Score = 61.6 bits (148), Expect = 1e-08
Identities = 35/115 (30%), Positives = 49/115 (42%), Gaps = 19/115 (16%)
Query: 1950 CASGPCPPHADCRDLWQTFSCTCQPGYYGPGC---VDACLLNPCQNQGSCRHLPGAPHGY 2006
C PC C +L FSC+C G+ G C ++ CL +PC+N C++ PG+ +
Sbjct: 3866 CLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGS---F 3922
Query: 2007 TCDCVGGYFGHHCEHRMDQQCPRGWWGSPTCGPCNCDVHKGFDPNCNKTNGQCHC 2061
C C GY G CE ++ C C PC G + CHC
Sbjct: 3923 NCVCKTGYTGKMCESSVN-YC--------ECNPC----FNGGSCQSGVDSYYCHC 3964
Score = 47.4 bits (111), Expect = 2e-04
Identities = 45/171 (26%), Positives = 59/171 (34%), Gaps = 47/171 (27%)
Query: 1983 DACLLNPCQNQGSC-RHLPGAP------------------HGYTCDCVGGYFGHHCEHRM 2023
D+C+ PCQN GSC R L + + C C+ GY G CE +
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDI 3863
Query: 2024 DQQCPRGWWGSPTC----GPCNCDVHKGFDPN-CNKTNGQC---------HCKEFHYRPR 2069
D+ P TC G +C GF C + +C C+ F
Sbjct: 3864 DECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNF----P 3919
Query: 2070 GSDSCLPCDCYPVGSTSRSCAPHSGQCPCRPGALGRQCNS------CDSPF 2114
GS +C+ G T + C C C P G C S C PF
Sbjct: 3920 GSFNCV----CKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPF 3966
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 473 bits (1217), Expect = e-132
Identities = 407/1482 (27%), Positives = 664/1482 (44%), Gaps = 172/1482 (11%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAA--LMNSRSLELFSIDP 380
P+F + Y V E+ GT + + A+ +G ++YSL S E F ID
Sbjct: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRAE-----HSGTVLYSLVKGNTPESNRDESFVIDR 2755
Query: 381 QSGLIRTAAALDRESMERHYL----RVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQA 436
QSG ++ +LD E+ + + R T DH + A+ V++ V D ND+SPVFE +
Sbjct: 2756 QSGRLKLEKSLDHETTKWYQFSILARCTQDDH---EMVASVDVSIQVKDANDNSPVFESS 2812
Query: 437 QYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIS 496
Y + EN+ G ++Q+RA+D D+ N + Y + +F I+ +G I+
Sbjct: 2813 PYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSL--DQSQSVEVIESFAINMETGWIT 2870
Query: 497 TSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE 556
T +D E ++Y++ V ASD G++ S+T V +TV D ND+ P+F+ + Y V E
Sbjct: 2871 TLKELDHEKRDNYQIKVVASDHGEKI-QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSE 2929
Query: 557 DVRPHTVVLRVTATDRD-KDANGLVHYNIISGNSRGHFAIDSLTGE--IQVVAPLDFEAE 613
D V+ ++ TD D ++ N V Y I G+ G FA++++ E + V PLD E
Sbjct: 2930 DDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKR 2989
Query: 614 REYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673
Y L I A D ++ + ++V+D ND+ P+ T + ++ E+ G ++ I
Sbjct: 2990 DNYLLTITATDG----TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQI 3045
Query: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGS 733
A DAD NA + Y+L G + F +N TG + S PLDRE Y V A D G
Sbjct: 3046 SATDADIRSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG 3104
Query: 734 PPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISY 791
AS+ +T+ DVNDN PEF+ Y + + E+ GT + V A D DA N I Y
Sbjct: 3105 R--FCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILY 3162
Query: 792 QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY----VHIN 847
+ + +F+I+ G+ + L PLD + + + L L A D+ L V ++
Sbjct: 3163 SLID-SADGQFSINELSGI--IQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVS 3219
Query: 848 ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL--EDNLPQFR 905
+ D N + PVF+ Y +V+ED +G+ ++ + A+ D+ NA ITY + + +F
Sbjct: 3220 VLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFS 3279
Query: 906 IDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
ID+ +GA+ + LDYE Y L + A D G P +D V V V D+NDN P F
Sbjct: 3280 IDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDT 3339
Query: 966 YTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRL 1025
YT ++SEDA SV+ + A D D +N + Y+ +G G FTI+P G V+ + L
Sbjct: 3340 YTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSS-FTIDPVRGEVKVTKLL 3398
Query: 1026 DREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSV 1085
DRE +S Y LT A D G PP ++ + V DVNDNAPVF + V ++EN VG
Sbjct: 3399 DRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFS 3458
Query: 1086 VAQITAVDPDEGPNAH-IMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQA 1144
V Q+ D D N + IV GN + F+++ G L + + + Y++ V+
Sbjct: 3459 VLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKV 3517
Query: 1145 TS--APLVSRAT-VHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201
P +S T + +R+++++ P + +I ++++ + + G+IG+I A D D
Sbjct: 3518 ADNGKPQLSSLTYIDIRVIEESIYPPAILPLEI----FITSSGEEYSGGVIGKIHATDQD 3573
Query: 1202 VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVL 1261
V D L YS + + L V+ T G+L +KLD + L+ V+VTDG + A +
Sbjct: 3574 VYDTLTYSLDPQMD-NLFSVSSTGGKLIAHKKLDIGQYLLN---VSVTDGKFTTVADITV 3629
Query: 1262 RVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTDV 1321
+ +T+E+L +++ +R N+ E F+ F + +L D+ I ++Q+
Sbjct: 3630 HIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVRRNDIQIVSLQSSEP- 3688
Query: 1322 GGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCLR 1381
L+V P A S+++L ++ + + +L +C
Sbjct: 3689 -HPHLDVLLFVEKPGSA-------QISTKQLLHKINSSVTDIEEIIGVRILNVFQKLCAG 3740
Query: 1382 EPCENYMKCVSVLRFDSSAPFLASASTL--FRPIQPIAGL----RCRCPPGFTGDFCETE 1435
C + C + D S S + L P A + RCPP G
Sbjct: 3741 LDCP-WKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVHHG------ 3793
Query: 1436 LDLCYSNPCRNGGACARR--EGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDA 1493
C +PC G C E +TCVC
Sbjct: 3794 ---CEDDPCPEGSECVSDPWEEKHTCVC-------------------------------- 3818
Query: 1494 PNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFR--GLRQRFHLTLSLSFATVQQSGL 1551
P+G F QCP ++ + +S+V +R + + L++ T +
Sbjct: 3819 PSGRFG-QCPGS----------SSMTLTGNSYVKYRLTENENKLEMKLTMRLRTYSTHAV 3867
Query: 1552 LFYNGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRY---Y 1608
+ Y D+ LE+ G+++ + G +VS ++DGQWH V L Y
Sbjct: 3868 VMY----ARGTDYSILEIHHGRLQYKFDCGSGPGIVS-VQSIQVNDGQWHAVALEVNGNY 3922
Query: 1609 NKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLT 1668
+ D + A G + + L++D+ + FG I T +S
Sbjct: 3923 ARLVLDQVHTASGTAPGTLKTLNLDN-----YVFFGGHIRQQG-------TRHGRS---- 3966
Query: 1669 GPLLLGGVPNLPENFPVSHKDFIGCMRDLHIDGRRVDM-------AAFVANNGTMAGC-Q 1720
P F GCM ++++G+ + + A + GC
Sbjct: 3967 ---------------PQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFL 4011
Query: 1721 AKLHFCDSGPCKNSGFCS-ERWGSFSCDCPVGFGGKDCQLTM 1761
C S PC+N G C+ G + C C + G C++++
Sbjct: 4012 TATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISV 4053
Score = 392 bits (1007), Expect = e-108
Identities = 278/858 (32%), Positives = 427/858 (49%), Gaps = 36/858 (4%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + P F Y+ + EN G+ V+++ A D D+G G+++YSL + +E F+
Sbjct: 2802 ANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFA 2861
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP-RLSATTMVAVTVADRNDHSPVFEQA 436
I+ ++G I T LD E + + ++V A DHG +LS+T +V VTV D ND P F
Sbjct: 2862 INMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAE 2921
Query: 437 QYRETLRENVEEGYPILQLRATDGDAPP-NANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Y+ T+ E+ +G I L TD D+ N + Y G A E +
Sbjct: 2922 IYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITG---GDPLGQFAVETIQNEWKV 2978
Query: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVR 555
+DRE ++Y L + A+D G S+ V + VLD NDN+P + Y +
Sbjct: 2979 YVKKPLDREKRDNYLLTITATD-----GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIP 3033
Query: 556 EDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE 615
EDV P ++++++ATD D +N + Y ++ G+ F ++ TGE++ PLD E +
Sbjct: 3034 EDVLPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTSTPLDREEQAV 3092
Query: 616 YALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQA 675
Y L +RA D G + L + D+ND+ P F + P+ ++V EN G + +QA
Sbjct: 3093 YHLLVRATDGGGRFCQASIVLT---LEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQA 3149
Query: 676 VDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP- 734
DAD G N ++ YSL A D F IN +G + + PLDRE Y ++A D G P
Sbjct: 3150 TDADAGLNRKILYSLIDSA-DGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPR 3208
Query: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
L+A+ +V V+VLD+NDN P F +EY ++ED VGT V+ V A RD AN+ I+Y
Sbjct: 3209 RLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYS 3268
Query: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD---RALHDHCYVHINIT 849
I GN +F+I ++ G V + LDY+ + L + A+D +L D V++N+T
Sbjct: 3269 IISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVT 3326
Query: 850 DANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL--PQFRID 907
D N + PVF Y+ ++ED + +++ + A D D N+ I Y + D F ID
Sbjct: 3327 DINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTID 3386
Query: 908 ADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYT 967
G + + LD E YTL + A DNG P + +TT V + V+DVNDNAP F +Y+
Sbjct: 3387 PVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYS 3446
Query: 968 GLVSEDAPPFTSVLQISATDRDAHANG-RVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLD 1026
++ E+ P SVLQ+ TD D+ NG +T G D + F + P G++ T +
Sbjct: 3447 VIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGND-EKAFEVNP-QGVLLTSSAIK 3504
Query: 1027 REAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
R+ Y L D G P L + I + V + + P E + G V+
Sbjct: 3505 RKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVI 3564
Query: 1087 AQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS 1146
+I A D D + Y + + + LF + G+L A LD +Y++ V T
Sbjct: 3565 GKIHATDQDVYDT--LTYSL-DPQMDNLFSVSSTGGKLIAHKKLDI---GQYLLNVSVTD 3618
Query: 1147 APL--VSRATVHVRLVDQ 1162
V+ TVH+R V Q
Sbjct: 3619 GKFTTVADITVHIRQVTQ 3636
Score = 388 bits (997), Expect = e-107
Identities = 273/873 (31%), Positives = 432/873 (49%), Gaps = 60/873 (6%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F NY+ V E+ GT ++ + A DPD G++G++ YSL F +D S
Sbjct: 925 PTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLL----DHGEGNFDVDKLS 980
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSP-RLSATTMVAVTVADRND--HSPVFEQAQYR 439
G +R LD E + + L V A+D G P LS+T V V V D N+ H PVF +
Sbjct: 981 GAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
T++E+ G ++ + A D DA + +RY + F+I +G+I TS
Sbjct: 1041 GTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI-----RDGSGVGVFKIGEETGVIETSD 1095
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVR 559
R+DRE Y L V A+DQG P S+ + ++I V D NDNAPQ SE Y ++ E+
Sbjct: 1096 RLDRESTSHYWLTVFATDQGVV--PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSP 1153
Query: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA-PLDFEAEREYAL 618
V+++ A D D +N + Y I SGN +G F+I TG I + LD E + E+ L
Sbjct: 1154 KDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHIL 1213
Query: 619 RIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS-------VI 671
+ D G PP S ++++D ND+ P F+ +++ + E +
Sbjct: 1214 EVTVTDNGSPPKS-TIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLY 1272
Query: 672 HIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDH 731
H+ A D D G NA + YS+ F I TG VS + E+ ++A D+
Sbjct: 1273 HVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG--VVSSKRFSAAGEYDILSIKAVDN 1330
Query: 732 GSPPLSASASV----------TVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781
G P S++ + ++ + ++ FT+ E ++ A V+SV
Sbjct: 1331 GRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVME-----SDPVAHMIGVISV--- 1382
Query: 782 DRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH 841
+ + ITGGN + F + G G + +A PLD +Q+ + L + A+D
Sbjct: 1383 -EPPGIPLWFDITGGNYDSHFDVDK--GTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL 1439
Query: 842 CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED-- 899
V I + D N HRP F ++ Y V + ED + I+ ISA D D E ++ Y L+
Sbjct: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIYTLQSSR 1497
Query: 900 ---NLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
+L +FR+D +G++ LD+E +TL + RD +P K + + V V+D ND
Sbjct: 1498 DPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTND 1557
Query: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTS 1016
+AP F AS Y G V E A + VLQ++A D+D N V Y+ ++G G+ F I+P
Sbjct: 1558 HAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGN-SFMIDPVL 1616
Query: 1017 GIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRV 1076
G ++T + LDR + Y+L A D+G PP+ S+++ V ++ +P F ++E+ V +
Sbjct: 1617 GSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVEL 1676
Query: 1077 KENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQ 1136
E +GS V +TA + ++Y+I +GN + F ++ SG + LD+E
Sbjct: 1677 SETVSIGSFVGMVTA-----HSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLP 1731
Query: 1137 EYVIVVQATS-APLVSRATVHVRLVDQNDNSPV 1168
Y +++Q T+ A L + TV V L D+NDN+PV
Sbjct: 1732 IYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPV 1764
Score = 376 bits (965), Expect = e-103
Identities = 283/947 (29%), Positives = 467/947 (49%), Gaps = 61/947 (6%)
Query: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
V EN+ G++V+ + + D D G G+LVY A+ F ID ++G+++ + LDR
Sbjct: 726 VKENQPVGSSVIFMNSTDLDTGFNGKLVY---AVSGGNEDSCFMIDMETGMLKILSPLDR 782
Query: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL 453
E+ +++ L +T D G P+ +A ++ V V D ND+ P F Q Y + E+ E I+
Sbjct: 783 ETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII 842
Query: 454 QLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVV 513
Q+ ATD D PN ++ Y V F ID +G+++ + +DRE + L +
Sbjct: 843 QVEATDKDLGPNGHVTYSIV-------TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKI 895
Query: 514 EASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRD 573
EA DQ +E +TV V +++ D NDN P F Y +VRED+ TV++ + A D D
Sbjct: 896 EARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPD 955
Query: 574 KDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNN 633
+G V Y+++ + G+F +D L+G +++V LDFE ++ Y L +RA+D G+P ++
Sbjct: 956 LGQSGQVRYSLLD-HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSS 1014
Query: 634 TGLASIQVVDIND--HIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLT 691
T ++VVD+N+ H P+F S + +V E+AP+G V+ + A D D + + YS+
Sbjct: 1015 TCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR 1074
Query: 692 GVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVND 751
+ F I TG + S LDRES HY+ V A D G PLS+ + + V DVND
Sbjct: 1075 DGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVND 1134
Query: 752 NRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGG 809
N P+ + Y+ + E++ SVV + A D D +N + Y+IT GN + F+I + G
Sbjct: 1135 NAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTG 1194
Query: 810 VGLVTLALPLDYKQERYFKLVLTASDRALHDH---CYVHINITDANTHRPVFQSAHYSVS 866
+ + T + LD +Q+ L +T +D V + I D N ++P F Y +
Sbjct: 1195 L-ITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIR 1253
Query: 867 VNE----DRPMGS---TIVVISASDDDVGENARITYLLEDNLP--QFRIDADSGAIT--- 914
+ E DR + + + A+D D G NA I+Y +ED +F I+ +G ++
Sbjct: 1254 LPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKR 1313
Query: 915 LQAPLDYEDQVTYTLAITARDNGIPQKADTT--YVEVMVNDVNDNAP-QFVASHYTGLVS 971
A +Y+ L+I A DNG PQK+ TT ++E + P F S +T V
Sbjct: 1314 FSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVM 1368
Query: 972 EDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVS 1031
E P + IS G + G + D F ++ +G + + LD E S
Sbjct: 1369 ESDPVAHMIGVIS-----VEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKS 1423
Query: 1032 VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITA 1091
Y LT A D G + T V I+V+ D ND+ P F ++EV + E++ + + QI+A
Sbjct: 1424 NYNLTVEATD-GTTTILTQVFIKVI--DTNDHRPQFSTSKYEVVIPEDTAPETEILQISA 1480
Query: 1092 VDPDEGPNAHIMYQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAP 1148
VD DE ++Y + P + F++D +G L LD+EA ++ + V
Sbjct: 1481 VDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQD 1538
Query: 1149 LVSR---ATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDH 1205
+ + A + V + D ND++P Y S ++ ++ A D D +
Sbjct: 1539 VPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYES----AAVGSVVLQVTALDKDKGKN 1594
Query: 1206 --LFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
+ YS E GN +++ G ++ +++LD + ++V TD
Sbjct: 1595 AEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATD 1641
Score = 375 bits (964), Expect = e-103
Identities = 298/948 (31%), Positives = 440/948 (46%), Gaps = 101/948 (10%)
Query: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
FS++ +GLI + R+ L VT D A+T V V V N + P F Q
Sbjct: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQ 465
Query: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Y+ ENV G ++ L A D D N + Y F ID +G +
Sbjct: 466 TAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN------LNHVPFAIDHFTGAV 519
Query: 496 STSGRVDREHMES-YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
STS +D E M Y L + ASD G P R V IT+ + NDN P F + +
Sbjct: 520 STSENLDYELMPRVYTLRIRASDWGL-PYRREVEVLATITLNNLNDNTPLFEKINCEGTI 578
Query: 555 REDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAER 614
D+ + V+A D D+ LV Y I +GN F+++ +G + + L
Sbjct: 579 PRDLGVGEQITTVSAIDADELQ--LVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGA 636
Query: 615 E---YALRIRAQDA---GRPPLSNNTGLASIQVVD------------------------- 643
+ ++LRI A D P N T AS ++V+
Sbjct: 637 KVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQ 696
Query: 644 ------------INDHIPIFVST-PFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL 690
+N HIP F ST P + V EN P+G SVI + + D D G N +L Y++
Sbjct: 697 GEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAV 756
Query: 691 TGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVN 750
+G D+ F+I+ TG + + PLDRE+ + Y + D G P +A + V V+D N
Sbjct: 757 SGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDAN 816
Query: 751 DNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQG 808
DN PEF + Y + ++ED V + ++ V A D+D N ++Y I + F+I +
Sbjct: 817 DNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV--TDTDTFSIDSVT 874
Query: 809 GVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHINITDANTHRPVFQSAHY 863
GV V +A PLD + + L + A D+A L V +++ D N + P F +Y
Sbjct: 875 GV--VNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNY 932
Query: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDNLPQFRIDADSGAITLQAPLDYE 922
V V ED P G+ I+ + A D D+G++ ++ Y LL+ F +D SGA+ + LD+E
Sbjct: 933 RVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFE 992
Query: 923 DQVTYTLAITARDNGIP-QKADTTYVEVMVNDVNDN--APQFVASHYTGLVSEDAPPFTS 979
+ Y L + A+D G P + T YVEV V DVN+N P F + G V EDAP +
Sbjct: 993 KKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSL 1052
Query: 980 VLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA 1039
V+ +SA D DA +G ++Y+ ++G G G F I +G++ T RLDRE+ S Y LT +A
Sbjct: 1053 VMTVSAHDEDARRDGEIRYSIRDG-SGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFA 1111
Query: 1040 VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPN 1099
D+GV PL + + I + V+DVNDNAP + + ENS V QI A DPD N
Sbjct: 1112 TDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSN 1171
Query: 1100 AHIMYQIVEGNIPELFQMDIFSGELTALI-DLDYEARQEYVIVVQAT---SAPLVSRATV 1155
+MY+I GN F + +G +T LD E + E+++ V T S P + A V
Sbjct: 1172 DKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARV 1231
Query: 1156 HVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAY-------DPDVSDHLFY 1208
V+++D+NDN P Q + + R R P Y D + + Y
Sbjct: 1232 IVKILDENDNKPQF--LQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISY 1289
Query: 1209 SFERGNELQLLVVNQTSGELRLSR-------------KLDNNRPLVAS 1243
S E GNE + +G + R +DN RP +S
Sbjct: 1290 SIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSS 1337
Score = 353 bits (905), Expect = 2e-96
Identities = 292/1029 (28%), Positives = 472/1029 (45%), Gaps = 93/1029 (9%)
Query: 305 RKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSL 364
RK ++ + A + P+F Q Y+ EN GT V+ + A DPD GE G + YS+
Sbjct: 443 RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSI 502
Query: 365 AALMNSRSLELFSIDPQSGLIRTAAALDRESMERHY-LRVTAQDHGSP-RLSATTMVAVT 422
A L + F+ID +G + T+ LD E M R Y LR+ A D G P R + +T
Sbjct: 503 ANLNHVP----FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATIT 558
Query: 423 VADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAA 482
+ + ND++P+FE+ T+ ++ G I + A D D + V
Sbjct: 559 LNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD-------ELQLVQYQIEAGNE 611
Query: 483 AAAFEIDPRSGLIST---------------SGRVDREHMESY------ELVVEASD---- 517
F ++P SG++S S R+ E++ + V AS
Sbjct: 612 LDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVN 671
Query: 518 -QGQEPGPRSATVR----------------VHITVLDENDNAPQFSEKRYVA-QVREDVR 559
Q +E G + N + PQF QV+E+
Sbjct: 672 LQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQP 731
Query: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALR 619
+ V+ + +TD D NG + Y + GN F ID TG +++++PLD E +Y L
Sbjct: 732 VGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLN 791
Query: 620 IRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
I D G P + L + VVD ND+ P F+ + V V E+ + +I ++A D D
Sbjct: 792 ITVYDLGIPQKA-AWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD 850
Query: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG--SPPLS 737
G N + YS+ V F I+S TG V+++ PLDRE + +EARD P L
Sbjct: 851 LGPNGHVTYSI--VTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLF 908
Query: 738 ASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA--ISYQITG 795
++ V V++ DVNDN P F Y +++ ED GT ++ + A D D + + Y +
Sbjct: 909 STVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLD 968
Query: 796 GNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR----ALHDHCYVHINITDA 851
N G V +V LD+++++ + L + A D+ +L CYV + + D
Sbjct: 969 HGEGNFDVDKLSGAVRIVQ---QLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDV 1025
Query: 852 --NTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED--NLPQFRID 907
N H PVF S +V ED P+GS ++ +SA D+D + I Y + D + F+I
Sbjct: 1026 NENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIG 1085
Query: 908 ADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYT 967
++G I LD E Y L + A D G+ + + + V DVNDNAPQ Y
Sbjct: 1086 EETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYY 1145
Query: 968 GLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV-RRLD 1026
+ E++P SV+QI A D D+ +N ++ Y +G + G F+I P +G++ T R+LD
Sbjct: 1146 PEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSG-NPQGFFSIHPKTGLITTTSRKLD 1204
Query: 1027 REAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRV-------KEN 1079
RE + L D G PP T + V + D NDN P F + +++R+ +E
Sbjct: 1205 REQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRER 1264
Query: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEY- 1138
+ + + A D DEGPNA I Y I +GN F ++ +G +++ + A EY
Sbjct: 1265 NARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSS---KRFSAAGEYD 1321
Query: 1139 VIVVQA--TSAPLVSRAT-VHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRI 1195
++ ++A P S T +H+ + + S +F+ F + SD + +IG I
Sbjct: 1322 ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVI 1380
Query: 1196 PAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSV 1255
P + L++ GN V++ +G + +++ LD + ++ V TDG ++
Sbjct: 1381 SVEPPGIP--LWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTI 1438
Query: 1256 TAQCVLRVV 1264
Q ++V+
Sbjct: 1439 LTQVFIKVI 1447
Score = 345 bits (885), Expect = 4e-94
Identities = 283/971 (29%), Positives = 459/971 (47%), Gaps = 64/971 (6%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F Y +V + G + V A D D+G G + Y L E F I P
Sbjct: 2079 PVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL-----KEHHEHFQIGPL- 2132
Query: 383 GLIRTAAALDRESMERHYL-RVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
G I + +++ + YL V A+D G+P SA +V +TV N PVFE+ Y
Sbjct: 2133 GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYSAE 2190
Query: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFV-GPPAARAAAAAAFEIDPRSGLISTSGR 500
+ E+++ P++ ++A ++P + Y G P ++ F I+ +G+I+
Sbjct: 2191 IAESIQVHSPVVHVQA---NSPEGLKVFYSITDGDPFSQ------FTINFNTGVINVIAP 2241
Query: 501 VDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRP 560
+D E +Y+L + A+D A V V I V D NDN P F+++ Y + E
Sbjct: 2242 LDFEAHPAYKLSIRATDSLTGA---HAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVI 2298
Query: 561 HTVVLRVTATDRDKDANGLVHYNIISGNSRGH--FAIDSLTGEIQVVAPLDFEAEREYAL 618
T V++V ATD D + N + Y + +S+ H F +DS TG I ++ LD+E R++ +
Sbjct: 2299 GTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTI 2358
Query: 619 RIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDA 678
+RA D G P LS++ + ++ V D+ND+ P+F ++ + E+AP GH V ++A DA
Sbjct: 2359 FVRAVDGGMPTLSSDV-IVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDA 2417
Query: 679 DHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSA 738
D + +L+YS+ FVI+SATG +++S L R +++ ++ + G +
Sbjct: 2418 DSSDIDKLQYSILSGNDHKHFVIDSATGIITLSN-LHRHALKPFYSLNLSVSDGV--FRS 2474
Query: 739 SASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN--SAISYQITGG 796
S V VTV+ N + P F EY + L E+A + T V+ V D D+ ++Y I
Sbjct: 2475 STQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVND 2534
Query: 797 NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALH-DHCYVHINITDANTHR 855
++RF I+ +G + + L + E+ + L A D C V++ +TD N +
Sbjct: 2535 FAKDRFYINERGQIFTLE-KLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNA 2593
Query: 856 PVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFR----IDADSG 911
P F++ Y V++ G+++V + ASD D G NA ITY +E + + I+ SG
Sbjct: 2594 PQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSG 2653
Query: 912 AITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVS 971
IT + L + +T + A DNG P K V V + P+F YT VS
Sbjct: 2654 VITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVS 2713
Query: 972 EDAPPFTSVLQISATDRDAHANGRVQYTFQNG----EDGDGDFTIEPTSGIVRTVRRLDR 1027
ED P T + I A +G V Y+ G + D F I+ SG ++ + LD
Sbjct: 2714 EDVPIGTEIDLIR-----AEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDH 2768
Query: 1028 EAVSVYELTAYA-VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
E Y+ + A + + V + + V+D NDN+PVF + +E + EN GS V
Sbjct: 2769 ETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRV 2828
Query: 1087 AQITAVDPDEGPNAHIMYQIVEG---NIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143
QI A D D G N +MY + + + E F +++ +G +T L +LD+E R Y I V
Sbjct: 2829 IQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVV 2888
Query: 1144 AT----SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG----IIGRI 1195
A+ L S A V V + D ND+ P + Y S+ P G I+
Sbjct: 2889 ASDHGEKIQLSSTAIVDVTVTDVNDSPP-----RFTAEIYKGTVSEDDPQGGVIAILSTT 2943
Query: 1196 PAYDPDVSDHLFYSFERGNELQLLVVN--QTSGELRLSRKLDNNRPLVASMLVTVTDGLH 1253
A +++ + Y G+ L V Q ++ + + LD + + +T TDG
Sbjct: 2944 DADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTF 3003
Query: 1254 SVTAQCVLRVV 1264
S A ++V+
Sbjct: 3004 SSKAIVEVKVL 3014
Score = 338 bits (868), Expect = 4e-92
Identities = 279/969 (28%), Positives = 447/969 (46%), Gaps = 57/969 (5%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ PQF Y+ ++PE+ A T +L++ A D D E +L+Y+L + + SL+ F +D
Sbjct: 1451 DHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLD 1508
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
P +G + T+ LD E++ +H L V +D P + V V+D NDH+P F + Y+
Sbjct: 1509 PATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYK 1568
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
+ E+ G +LQ+ A D D NA + Y +F IDP G I T+
Sbjct: 1569 GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSI-----ESGNIGNSFMIDPVLGSIKTAK 1623
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVR 559
+DR + Y+L+V+A+D+G P +VR+ +T+ D + +P+F+ K Y ++ E V
Sbjct: 1624 ELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD--NASPKFTSKEYSVELSETVS 1681
Query: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALR 619
+ V VTA + V Y I GN+ F I+ +G I LDFE Y L
Sbjct: 1682 IGSFVGMVTAHSQSS-----VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLI 1736
Query: 620 IRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH------- 672
I Q LS NT + + + D ND+ P+F+ + + E+A + V+
Sbjct: 1737 I--QGTNMAGLSTNTTVL-VHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLV 1793
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG 732
I+A DAD NA L Y + + T F I+S+TG + LD E + F V+ D G
Sbjct: 1794 IRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMG 1853
Query: 733 SPPLSA--SASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN--SA 788
+P L A +A+VTV V+D+ND P F Y L G V++V A D D++ S
Sbjct: 1854 TPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQ 1913
Query: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINI 848
+ Y IT GN +F++ + G V L + RY +L + ASD V IN+
Sbjct: 1914 LIYSITEGNIGEKFSMDYKTGALTVQNTTQL---RSRY-ELTVRASDGRFAGLTSVKINV 1969
Query: 849 TDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDA 908
++ F YS V E+ T+ VI+A + + E L D +F+I
Sbjct: 1970 KESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDR--RFKISR 2027
Query: 909 DSGAI-TLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYT 967
SG + T P D E Q + + + + P V+V+V D NDNAP FV Y
Sbjct: 2028 TSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYY 2087
Query: 968 GLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDR 1027
+V D + ++A DRD+ NG V Y + + F I P G + ++ +
Sbjct: 2088 AVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHE---HFQIGPL-GEISLKKQFEL 2143
Query: 1028 EAVS-VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
+ ++ Y +T A D G P V + + V +N PVF + + E+ V S V
Sbjct: 2144 DTLNKEYLVTVVAKDGGNPAFSAEVIVPITV--MNKAMPVFEKPFYSAEIAESIQVHSPV 2201
Query: 1087 AQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS 1146
+ A P+ + Y I +G+ F ++ +G + + LD+EA Y + ++AT
Sbjct: 2202 VHVQANSPE---GLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATD 2258
Query: 1147 APLVSRATVHVRLV--DQNDNSPVLNNFQILFNNYVSNRSDTFPSGI-IGRIPAYDPDVS 1203
+ + A V V ++ D NDN PV +Y S+ G + ++ A D D
Sbjct: 2259 SLTGAHAEVFVDIIVDDINDNPPVFAQ-----QSYAVTLSEASVIGTSVVQVRATDSDSE 2313
Query: 1204 DHLFYSFER-GNELQL---LVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQC 1259
+ S++ GN + V+ ++G + L R LD + ++ V DG +
Sbjct: 2314 PNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSD 2373
Query: 1260 VLRVVIITE 1268
V+ V +T+
Sbjct: 2374 VIVTVDVTD 2382
Score = 326 bits (835), Expect = 3e-88
Identities = 289/1025 (28%), Positives = 465/1025 (45%), Gaps = 103/1025 (10%)
Query: 297 GLPARPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGE 356
GLP R E + + + P F + N + +P + G + V A D D E
Sbjct: 544 GLPYRREVEVLATIT---LNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD--E 598
Query: 357 AGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALD---RESMERHYLRVTAQD------ 407
+ Y + A L+ FS++P SG++ +L + H LR+TA D
Sbjct: 599 LQLVQYQIEA---GNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT 655
Query: 408 -----------HGSPRLSA-TTMVAVTVADR------------------NDHSPVFEQAQ 437
H L T VA +A++ + HS Q
Sbjct: 656 PLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQ 715
Query: 438 YRETL------RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPR 491
+R TL +EN G ++ + +TD D N L Y G + F ID
Sbjct: 716 FRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSG-----GNEDSCFMIDME 770
Query: 492 SGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVR-VHITVLDENDNAPQFSEKRY 550
+G++ +DRE + Y L + D G P+ A R +H+ V+D NDN P+F ++ Y
Sbjct: 771 TGMLKILSPLDRETTDKYTLNITVYDLGI---PQKAAWRLLHVVVVDANDNPPEFLQESY 827
Query: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
+V ED H+ +++V ATD+D NG V Y+I++ F+IDS+TG + + PLD
Sbjct: 828 FVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT--FSIDSVTGVVNIARPLDR 885
Query: 611 EAEREYALRIRAQDAGR-PPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
E + E++L+I A+D R P +T + + + D+ND+ P F+ ++V V E+ P G
Sbjct: 886 ELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTV 945
Query: 670 VIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEAR 729
++ ++A D D G++ ++ YSL + F ++ +G V + LD E + Y V A+
Sbjct: 946 IMWLEAHDPDLGQSGQVRYSLLDHG-EGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAK 1004
Query: 730 DHGSP-PLSASASVTVTVLDVNDN--RPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA- 785
D G P LS++ V V V+DVN+N P F+ + EDA VG+ V++V+A D DA
Sbjct: 1005 DKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
Query: 786 -NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDH 841
+ I Y I G+ F I + GV + + LD + ++ L + A+D+ L
Sbjct: 1065 RDGEIRYSIRDGSGVGVFKIGEETGV--IETSDRLDRESTSHYWLTVFATDQGVVPLSSF 1122
Query: 842 CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL 901
++I + D N + P Y + E+ P ++V I A D D N ++ Y +
Sbjct: 1123 IEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGN 1182
Query: 902 PQ--FRIDADSGAITLQA-PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNA 958
PQ F I +G IT + LD E Q + L +T DNG P K+ V V + D NDN
Sbjct: 1183 PQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
Query: 959 PQFVASHYTGLVSEDAPPFTS-------VLQISATDRDAHANGRVQYTFQNGEDGDGDFT 1011
PQF+ Y + E P + + ATD+D N + Y+ ++G + G F
Sbjct: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNE-HGKFF 1301
Query: 1012 IEPTSGIVRTVRRLDREAVSVYE-LTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAE 1070
IEP +G+V + R A Y+ L+ AVD G P + + ++ ++ ++ P
Sbjct: 1302 IEPKTGVVSSKR---FSAAGEYDILSIKAVDNGRP--QKSSTTRLHIEWISKPKPSLEPI 1356
Query: 1071 EFEVRVKENSIVGS-VVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALID 1129
FE +++ S VA + V E P + + I GN F +D +G +
Sbjct: 1357 SFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKP 1416
Query: 1130 LDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNY-VSNRSDTFP 1188
LD E + Y + V+AT V ++++D ND+ P Q + Y V DT P
Sbjct: 1417 LDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRP-----QFSTSKYEVVIPEDTAP 1471
Query: 1189 SGIIGRIPAYDPDVSDHLFYSFERGNE---LQLLVVNQTSGELRLSRKLDNNRPLVASML 1245
I +I A D D + L Y+ + + L+ ++ +G L S KLD+ ++
Sbjct: 1472 ETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLT 1531
Query: 1246 VTVTD 1250
V V D
Sbjct: 1532 VMVRD 1536
Score = 324 bits (830), Expect = 1e-87
Identities = 270/999 (27%), Positives = 444/999 (44%), Gaps = 103/999 (10%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F +Y +PEN A T++ RV A D D G G YS ++F+I P S
Sbjct: 147 PLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF-----KDRTDMFAIHPTS 201
Query: 383 GLIRTAAALDRESMERHYLRVTAQD-----HGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
G+I LD + + + + A D +GS +S+ + V + N+ +PV
Sbjct: 202 GVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVT 261
Query: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
+ + + Y I+ + D A + G + +F + +
Sbjct: 262 LSPSELDR-DPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFP-GSKEYKVKA 319
Query: 498 SGRVDRE-HMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE 556
G +D + H Y L ++A D+G P S V +H+T +F + Y A++ E
Sbjct: 320 IGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKV-IHVTSPQFKAGPVKFEKDVYRAEISE 378
Query: 557 DVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREY 616
P+T V+ V A A + Y S + F+++ TG I ++ P+ + +
Sbjct: 379 FAPPNTPVVMVKAI----PAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHF 434
Query: 617 ALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAV 676
L + D + ++V+ N + P F T ++ + EN P+G +V+ + AV
Sbjct: 435 ELEVTTSD------RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAV 488
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEH-YFFGVEARDHGSP- 734
D D GEN + YS+ + PF I+ TG VS S LD E + Y + A D G P
Sbjct: 489 DPDEGENGYVTYSIANL-NHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPY 547
Query: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQIT 794
T+T+ ++NDN P F + D VG + +V+A+D D + YQI
Sbjct: 548 RREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIE 607
Query: 795 GGNTRNRFAISTQGGV---------GL----------VTLALPLDYKQERYFKLVLTASD 835
GN + F+++ GV GL +T ++ Y + + AS
Sbjct: 608 AGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASH 667
Query: 836 RALHDHCY--------------------------VHINITDANTHRPVFQSA-HYSVSVN 868
+ ++ C + + N H P F+S + V
Sbjct: 668 KLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVK 727
Query: 869 EDRPMGSTIVVISASDDDVGENARITYLL----EDNLPQFRIDADSGAITLQAPLDYEDQ 924
E++P+GS+++ ++++D D G N ++ Y + ED+ F ID ++G + + +PLD E
Sbjct: 728 ENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSC--FMIDMETGMLKILSPLDRETT 785
Query: 925 VTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQIS 984
YTL IT D GIPQKA + V+V D NDN P+F+ Y VSED + ++Q+
Sbjct: 786 DKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
Query: 985 ATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD--R 1042
ATD+D NG V Y+ D F+I+ +G+V R LDRE + L A D R
Sbjct: 846 ATDKDLGPNGHVTYSIVTDTD---TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAR 902
Query: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
P L + V ++V ++DVNDN P F + V+V+E+ G+V+ + A DPD G + +
Sbjct: 903 EEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQV 962
Query: 1103 MYQIV---EGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS----APLVSRATV 1155
Y ++ EGN F +D SG + + LD+E +Q Y + V+A L S V
Sbjct: 963 RYSLLDHGEGN----FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYV 1018
Query: 1156 HVRLVDQNDN--SPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDV--SDHLFYSFE 1211
V +VD N+N PV ++F + + D ++ + A+D D + YS
Sbjct: 1019 EVEVVDVNENLHPPVFSSFV----EKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR 1074
Query: 1212 RGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
G+ + + + + +G + S +LD + V TD
Sbjct: 1075 DGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATD 1113
Score = 306 bits (785), Expect = 2e-82
Identities = 270/978 (27%), Positives = 452/978 (46%), Gaps = 71/978 (7%)
Query: 323 PQFPQYNYQTLVPENE-------AAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLEL 375
PQF Q Y+ +PE E A + V+A D D G + YS+ +
Sbjct: 1243 PQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIE---DGNEHGK 1299
Query: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
F I+P++G++ + + E L + A D+G P+ S+TT + + + P E
Sbjct: 1300 FFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKP--KPSLEP 1355
Query: 436 AQYRETLRE-NVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
+ E+ V E P+ + PP L + G + F++D +G
Sbjct: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITG-----GNYDSHFDVDKGTGT 1410
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
I + +D E +Y L VEA+D G + +V I V+D ND+ PQFS +Y +
Sbjct: 1411 IIVAKPLDAEQKSNYNLTVEATD-----GTTTILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
Query: 555 REDVRPHTVVLRVTATDRDKDANGLVHYNIISGN---SRGHFAIDSLTGEIQVVAPLDFE 611
ED P T +L+++A D+D + N L+ Y + S S F +D TG + LD E
Sbjct: 1466 PEDTAPETEILQISAVDQD-EKNKLI-YTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHE 1523
Query: 612 AEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVI 671
A ++ L + +D P+ N + V D NDH P F ++ ++ V E+A +G V+
Sbjct: 1524 AVHQHTLTVMVRDQD-VPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVL 1582
Query: 672 HIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDH 731
+ A+D D G+NA + YS+ F+I+ G + + LDR + Y V+A D
Sbjct: 1583 QVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDK 1642
Query: 732 GSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISY 791
GSPP+S SV + V ++ P+FT KEY + L+E ++G+ V VTA + S++ Y
Sbjct: 1643 GSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA---HSQSSVVY 1699
Query: 792 QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHINITD 850
+I GNT + F I+ G + A LD++ + L++ ++ A L + V +++ D
Sbjct: 1700 EIKDGNTGDAFDINPHSGTIITQKA--LDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQD 1757
Query: 851 ANTHRPVFQSAHYSVSVNEDRPMGSTI-------VVISASDDDVGENARITY-LLEDNL- 901
N + PVF A Y+ ++E + S + +VI A+D D NA + Y ++E ++
Sbjct: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVH 1817
Query: 902 PQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQ--KADTTYVEVMVNDVNDNAP 959
F ID+ +GAI LDYE+ + + D G P+ V V V D+ND P
Sbjct: 1818 TYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPP 1877
Query: 960 QFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIV 1019
F Y + V+ ++ATD D+ A ++ Y+ G G+ F+++ +G +
Sbjct: 1878 VFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGE-KFSMDYKTGAL 1936
Query: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
TV+ + S YELT A D L S+++ V++ ++ F + + VKEN
Sbjct: 1937 -TVQN-TTQLRSRYELTVRASDGRFAGL---TSVKINVKESKESHLKFTQDVYSAVVKEN 1991
Query: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGEL-TALIDLDYEARQEY 1138
S +A ITA+ N + Y I+ N F++ SG L T D E ++ +
Sbjct: 1992 STEAETLAVITAI--GNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDREQQEAF 2047
Query: 1139 VIVVQAT---SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRI 1195
+VV+ T V+ V V + DQNDN+PV N Y + DT +I +
Sbjct: 2048 DVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPY----YAVVKVDTEVGHVIRYV 2103
Query: 1196 PAYDPDV---SDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGL 1252
A D D + +Y E Q+ + + S L+ +LD +V G
Sbjct: 2104 TAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEIS--LKKQFELDTLNKEYLVTVVAKDGGN 2161
Query: 1253 HSVTAQCVLRVVIITEEL 1270
+ +A+ ++ + ++ + +
Sbjct: 2162 PAFSAEVIVPITVMNKAM 2179
Score = 302 bits (773), Expect = 4e-81
Identities = 276/982 (28%), Positives = 425/982 (43%), Gaps = 58/982 (5%)
Query: 302 PEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLV 361
P ++TS R A N P+F Y + E + G+ V V A + +V
Sbjct: 1645 PPMSEITSV-RIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VV 1698
Query: 362 YSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAV 421
Y + + + + F I+P SG I T ALD E++ + L + Q LS T V V
Sbjct: 1699 YEIK---DGNTGDAFDINPHSGTIITQKALDFETLPIYTLII--QGTNMAGLSTNTTVLV 1753
Query: 422 TVADRNDHSPVFEQAQYRETLRENVEEGYPILQ-------LRATDGDAPPNANLRYRFVG 474
+ D ND++PVF QA+Y + E+ +L +RA D D NA L Y V
Sbjct: 1754 HLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVE 1813
Query: 475 PPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHIT 534
P + F ID +G I T +D E + V+ D G V +
Sbjct: 1814 P-----SVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVH 1868
Query: 535 VLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFA 594
V+D ND P F++ Y A + V+ V ATD D A + Y+I GN F+
Sbjct: 1869 VIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFS 1928
Query: 595 IDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVST 654
+D TG + V + Y L +RA D L++ I V + + F
Sbjct: 1929 MDYKTGALTVQNTTQLRSR--YELTVRASDGRFAGLTS----VKINVKESKESHLKFTQD 1982
Query: 655 PFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSG-P 713
+ V EN+ ++ I A+ + N L Y + PD F I+ +G +S +G P
Sbjct: 1983 VYSAVVKENSTEAETLAVITAIG--NPINEPLFYHILN--PDRRFKISRTSGVLSTTGTP 2038
Query: 714 LDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGT 773
DRE E + VE + P A V V V D NDN P F Y+ + D VG
Sbjct: 2039 FDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGH 2098
Query: 774 SVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVL 831
+ VTAVDRD+ N + Y + F I G + L LD + Y V+
Sbjct: 2099 VIRYVTAVDRDSGRNGEVHYYLK--EHHEHFQIGPLGEISLKK-QFELDTLNKEYLVTVV 2155
Query: 832 TASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENA 891
V + IT N PVF+ YS + E + S +V + A+ E
Sbjct: 2156 AKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSP---EGL 2212
Query: 892 RITYLLEDNLP--QFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEV 949
++ Y + D P QF I+ ++G I + APLD+E Y L+I A D+ A+ +V++
Sbjct: 2213 KVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEV-FVDI 2271
Query: 950 MVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYT-FQNGEDGDG 1008
+V+D+NDN P F Y +SE + TSV+Q+ ATD D+ N + Y F N
Sbjct: 2272 IVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHD 2331
Query: 1009 DFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFP 1068
F ++ ++G++ +R LD E + + AVD G+P L + V + V V D+NDN P+F
Sbjct: 2332 HFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFE 2391
Query: 1069 AEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALI 1128
+ +E R+ E++ G V + A D D + Y I+ GN + F +D +G +T
Sbjct: 2392 QQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSN 2451
Query: 1129 DLDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFP 1188
+ + Y + + + S VHV ++ N +SP L N Y ++ P
Sbjct: 2452 LHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPA-----FLQNEYEVELAENAP 2506
Query: 1189 -SGIIGRIPAYDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPL--VAS 1243
++ + D D + H+ Y +N+ G++ KLD P V S
Sbjct: 2507 LHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
Query: 1244 MLVTVTDGLHSVTAQCVLRVVI 1265
+ + D V A C + V++
Sbjct: 2566 VRLMAKDAGGKV-AFCTVNVIL 2586
Score = 261 bits (668), Expect = 6e-69
Identities = 279/1034 (26%), Positives = 447/1034 (43%), Gaps = 134/1034 (12%)
Query: 324 QFPQYNYQTLVPENEAAGTAV-----LRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI 378
QF Y V EN AA T V + V P A E + S + ++ E
Sbjct: 33 QFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHP-AWEVRYKIVSGDSENLFKAEEYILG 91
Query: 379 DPQSGLIRT----AAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFE 434
D IRT A L+RE + + L V A + + + A T V V V D ND P+F
Sbjct: 92 DFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNT-NVEARTKVRVQVLDTNDLRPLFS 150
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Y +L EN I ++ ATD D N Y F F I P SG+
Sbjct: 151 PTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF-------KDRTDMFAIHPTSGV 203
Query: 495 ISTSGRVDREHMESYELVVEASDQGQE---PGPRSATVRVHITVLDENDNAPQFSEKRYV 551
I +GR+D + YE+ + A+D+G + S+ ++ + + N+ AP + V
Sbjct: 204 IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA---V 260
Query: 552 AQVREDVRPHTVVLRVTATDRDKDANG-LVHYNIISGNSRGHF-AIDSLTG----EIQVV 605
++ VT D D+ ANG + +I++G+ F + S G +++ +
Sbjct: 261 TLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAI 320
Query: 606 APLDFEAER-EYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTP-------FQ 657
+D+++ Y L ++A+D G PP +S++V+ + P F + P ++
Sbjct: 321 GGIDWDSHPFGYNLTLQAKDKGTPP-----QFSSVKVIHVTS--PQFKAGPVKFEKDVYR 373
Query: 658 VSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRE 717
+ E AP V+ ++A+ A + L Y F +N TG +S+ P+ R+
Sbjct: 374 AEISEFAPPNTPVVMVKAIPA----YSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQ 429
Query: 718 SVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS 777
H+ V D AS V V VL N N PEFT Y +E+ +GT+V+S
Sbjct: 430 QAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS 484
Query: 778 VTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK-QERYFKLVLTAS 834
++AVD D N ++Y I N + G V+ + LDY+ R + L + AS
Sbjct: 485 LSAVDPDEGENGYVTYSIA---NLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
Query: 835 DRALHDHCYVH----INITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGEN 890
D L V I + + N + P+F+ + ++ D +G I +SA D D E
Sbjct: 542 DWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD--EL 599
Query: 891 ARITYLLE--DNLPQFRIDADSGAITLQAPL--DYEDQVTY-TLAITARDNGIPQKADTT 945
+ Y +E + L F ++ +SG ++L+ L +V++ +L ITA D A
Sbjct: 600 QLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDG--ENFATPL 657
Query: 946 YVEVMV-------------------------------------------NDVNDNAPQFV 962
Y+ + V + VN + PQF
Sbjct: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
Query: 963 ASHYTGL-VSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRT 1021
++ TG+ V E+ P +SV+ +++TD D NG++ Y G + D F I+ +G+++
Sbjct: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNE-DSCFMIDMETGMLKI 776
Query: 1022 VRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSI 1081
+ LDRE Y L D G+P + V+V D NDN P F E + V V E+
Sbjct: 777 LSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKE 836
Query: 1082 VGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIV 1141
V S + Q+ A D D GPN H+ Y IV + F +D +G + LD E + E+ +
Sbjct: 837 VHSEIIQVEATDKDLGPNGHVTYSIVTDT--DTFSIDSVTGVVNIARPLDRELQHEHSLK 894
Query: 1142 VQA-----TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIP 1196
++A L S V V L D NDN P I N V R D +I +
Sbjct: 895 IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTF----IPPNYRVKVREDLPEGTVIMWLE 950
Query: 1197 AYDPDV--SDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLH- 1253
A+DPD+ S + YS E V++ SG +R+ ++LD + V ++ V D
Sbjct: 951 AHDPDLGQSGQVRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKP 1009
Query: 1254 -SVTAQCVLRVVII 1266
S+++ C + V ++
Sbjct: 1010 VSLSSTCYVEVEVV 1023
Score = 217 bits (553), Expect = 1e-55
Identities = 232/906 (25%), Positives = 387/906 (42%), Gaps = 109/906 (12%)
Query: 424 ADRNDHSPV-FEQAQYRETLRENVEE----GYPI-LQLRATDGDAPPNANLRYRFVGPPA 477
+ R + +P+ F +Y T++EN G+P+ + + T P +RY+ V +
Sbjct: 24 SQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITH----PAWEVRYKIVSGDS 79
Query: 478 ARAAAAAAFEIDPRSGL-ISTSGR----VDREHMESYELVVEASDQGQEPGPRSATVRVH 532
A + + L I T G ++RE + Y L+V+A ++ R+ +V
Sbjct: 80 ENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEART---KVR 136
Query: 533 ITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGH 592
+ VLD ND P FS Y + E+ T + RV+ATD D NG +Y+ +
Sbjct: 137 VQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF--KDRTDM 194
Query: 593 FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS-----IQVVDINDH 647
FAI +G I + LD+ + Y + I A D G L ++G++S + + N+
Sbjct: 195 FAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGM-KLYGSSGISSMAKLTVHIEQANEC 253
Query: 648 IPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGW 707
P+ + S L+ P ++++ + D D G N + SL+ VA D + +
Sbjct: 254 APVITAVTLSPSELDRDP-AYAIVTVD--DCDQGANGDIA-SLSIVAGDLLQQFRTVRSF 309
Query: 708 -------VSVSGPLDRESVEH-YFFGVEARDHGSPPLSASASVT-VTVLDVNDNRPEFTM 758
V G +D +S Y ++A+D G+PP +S V VT +F
Sbjct: 310 PGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEK 369
Query: 759 KEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALP 818
Y ++E A T VV V A+ ++ ++ T G + S GL+++ P
Sbjct: 370 DVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAK----FSLNYNTGLISILEP 425
Query: 819 LDYKQERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIV 878
+ +Q +F+L +T SDR V + + AN++ P F Y + +E+ P+G+T++
Sbjct: 426 VKRQQAAHFELEVTTSDRKASTK--VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483
Query: 879 VISASDDDVGENARITYLLED-NLPQFRIDADSGAITLQAPLDYEDQV-TYTLAITARDN 936
+SA D D GEN +TY + + N F ID +GA++ LDYE YTL I A D
Sbjct: 484 SLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDW 543
Query: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGR 995
G+P + + + +N++NDN P F + G + D + +SA D D
Sbjct: 544 GLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--L 601
Query: 996 VQYTFQNGEDGDGDFTIEPTSGIVRTVRRLD---REAVSVYELTAYAVDRGVPPLRTPVS 1052
VQY + G + D F++ P SG++ R L VS + L A D TP+
Sbjct: 602 VQYQIEAGNELD-FFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDG--ENFATPLY 658
Query: 1053 IQVMV-------------------------------------------QDVNDNAPVFPA 1069
I + V VN + P F +
Sbjct: 659 INITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRS 718
Query: 1070 E-EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALI 1128
++VKEN VGS V + + D D G N ++Y + GN F +D+ +G L L
Sbjct: 719 TLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILS 778
Query: 1129 DLDYEARQEYVIVVQATSAPLVSRAT---VHVRLVDQNDNSPVLNNFQILFNNY-VSNRS 1184
LD E +Y + + + +A +HV +VD NDN P + L +Y V
Sbjct: 779 PLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPP-----EFLQESYFVEVSE 833
Query: 1185 DTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASM 1244
D I ++ A D D+ + ++ + ++ +G + ++R LD S+
Sbjct: 834 DKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSL 893
Query: 1245 LVTVTD 1250
+ D
Sbjct: 894 KIEARD 899
Score = 172 bits (435), Expect = 6e-42
Identities = 155/587 (26%), Positives = 257/587 (43%), Gaps = 53/587 (9%)
Query: 714 LDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGT 773
L+RE +HY V+A + + + A V V VLD ND RP F+ Y + L E+ A+ T
Sbjct: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
Query: 774 SVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTA 833
S+ V+A D D + + + + + FAI GV + L LDY + + +++ + A
Sbjct: 167 SIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGV--IVLTGRLDYLETKLYEMEILA 224
Query: 834 SDR--------ALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDD 885
+DR + + ++I AN PV + S S + P + + V
Sbjct: 225 ADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQG 284
Query: 886 DVGENARITYLLEDNLPQFRI-----DADSGAITLQAPLDYEDQ-VTYTLAITARDNGI- 938
G+ A ++ + D L QFR + + +D++ Y L + A+D G
Sbjct: 285 ANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTP 344
Query: 939 PQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY 998
PQ + + V +F Y +SE APP T V+ + A +H ++Y
Sbjct: 345 PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSH----LRY 400
Query: 999 TFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQ 1058
F++ G F++ +G++ + + R+ + +EL DR + + V V
Sbjct: 401 VFKS-TPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR-----KASTKVLVKVL 454
Query: 1059 DVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGN-IPELFQM 1117
N N P F ++ EN +G+ V ++AVDPDEG N ++ Y I N +P F +
Sbjct: 455 GANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP--FAI 512
Query: 1118 DIFSGELTALIDLDYEAR-QEYVIVVQATSAPLVSRATVHV----RLVDQNDNSPVLNNF 1172
D F+G ++ +LDYE + Y + ++A+ L R V V L + NDN+P+
Sbjct: 513 DHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKI 572
Query: 1173 QILFNNYVSNRSDTFPSGI-----IGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGE 1227
N T P + I + A D D + Y E GNEL +N SG
Sbjct: 573 ---------NCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGV 623
Query: 1228 LRLSRKLDNN---RPLVASMLVTVTDGLHSVTAQCVLRVVIITEELL 1271
L L R L + + S+ +T TDG + T + V + +L+
Sbjct: 624 LSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLV 670
Score = 84.7 bits (208), Expect = 1e-15
Identities = 40/100 (40%), Positives = 54/100 (54%), Gaps = 6/100 (6%)
Query: 1415 PIAGLRCRCPPGFTGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDT 1474
P G C+C + G CE ++ C S PC GG C GG+ C CR +TG+ C+L
Sbjct: 4032 PAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQL-- 4089
Query: 1475 EAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCE 1514
+ C C+NGGTC D+ +G CQC +G F G RC+
Sbjct: 4090 -SPYCKDEPCKNGGTCFDSLDGAV-CQCDSG--FRGERCQ 4125
Score = 83.6 bits (205), Expect = 3e-15
Identities = 99/403 (24%), Positives = 144/403 (35%), Gaps = 67/403 (16%)
Query: 1719 CQAKLHFCDSGPCKNSGFC-SERWGS-FSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWN 1776
C H C+ PC C S+ W +C CP G G Q + GN + +
Sbjct: 3787 CPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFG---QCPGSSSMTLTGNSYVKYR 3843
Query: 1777 FGSDMAVSVPWYLGLAFRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHL 1836
++ + L + RT +T V+M + +S L ++ G L GSG +
Sbjct: 3844 L-TENENKLEMKLTMRLRTYSTHAVVMYARGTDYSIL--EIHHGRLQYKFDCGSGPGI-V 3899
Query: 1837 LLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQL- 1895
+ + V+DG+WH + LE+ G++ +V L Q A G+ LK L
Sbjct: 3900 SVQSIQVNDGQWHAVALEV-------NGNYARLV-----LDQVHTASGTAPGTLKTLNLD 3947
Query: 1896 -------HV--GGLPPGSAEEAPQGLVGCIQGVWLGSTP----SGSPALLPPSHRVNAEP 1942
H+ G G + + G GC+ ++L S + V+ P
Sbjct: 3948 NYVFFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSP 4007
Query: 1943 GC--VVTNACASGPCPPHADCR-DLWQTFSCTCQPGYYGPGC---VDACLLNPCQNQGSC 1996
GC T CAS PC C + C C Y G C V+ C PC G+C
Sbjct: 4008 GCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTC 4067
Query: 1997 RHLPGAPHGYTCDCVGGYFGHHCE---HRMDQQCPRGWWGSPTCGPCNCDVHKGFDPN-- 2051
G G+ C C G Y G C+ + D+ C G + C GF
Sbjct: 4068 VVDNG---GFVCQCRGLYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERC 4124
Query: 2052 -----------------CNKTNGQCHCKEFH-YRPRGSDSCLP 2076
C T+G HC H YR R + P
Sbjct: 4125 QSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAAP 4167
Score = 66.6 bits (161), Expect = 4e-10
Identities = 35/84 (41%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 1434 TELDLCYSNPCRNGGAC-ARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTD 1492
T + C SNPC+NGG C GGY C C + G CE+ C C GGTC
Sbjct: 4012 TATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNP--CSSKPCLYGGTCV- 4068
Query: 1493 APNGGFRCQCPAGGAFEGPRCEVA 1516
NGGF CQC G + G RC+++
Sbjct: 4069 VDNGGFVCQC--RGLYTGQRCQLS 4090
Score = 61.2 bits (147), Expect = 2e-08
Identities = 33/100 (33%), Positives = 44/100 (44%), Gaps = 6/100 (6%)
Query: 1418 GLRCRCPPGFTGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAG 1477
G C+C +TG C+ C PC+NGG C G C C F GE C+ D +
Sbjct: 4073 GFVCQCRGLYTGQRCQLS-PYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDID-- 4129
Query: 1478 RCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAA 1517
C C +G C + +G + C C + G CE AA
Sbjct: 4130 ECSGNPCLHGALCENT-HGSYHCNC--SHEYRGRHCEDAA 4166
Score = 60.5 bits (145), Expect = 3e-08
Identities = 30/93 (32%), Positives = 40/93 (43%), Gaps = 22/93 (23%)
Query: 1379 CLREPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDL 1438
C EPC+N C FDS + G C+C GF G+ C++++D
Sbjct: 4093 CKDEPCKNGGTC-----FDS-----------------LDGAVCQCDSGFRGERCQSDIDE 4130
Query: 1439 CYSNPCRNGGACARREGGYTCVCRPRFTGEDCE 1471
C NPC +G C G Y C C + G CE
Sbjct: 4131 CSGNPCLHGALCENTHGSYHCNCSHEYRGRHCE 4163
Score = 52.0 bits (123), Expect = 1e-05
Identities = 27/86 (31%), Positives = 35/86 (40%), Gaps = 6/86 (6%)
Query: 1944 CVVTNACASGPCPPHADCRDLWQTFSCTCQPGYYGPGC---VDACLLNPCQNQGSCRHLP 2000
C ++ C PC C D C C G+ G C +D C NPC + C +
Sbjct: 4087 CQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCENTH 4146
Query: 2001 GAPHGYTCDCVGGYFGHHCEHRMDQQ 2026
G+ Y C+C Y G HCE Q
Sbjct: 4147 GS---YHCNCSHEYRGRHCEDAAPNQ 4169
Score = 42.0 bits (97), Expect = 0.010
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 17/74 (22%)
Query: 1719 CQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFG 1778
CQ+ + C PC + C GS+ C+C + G+ C+ A P+ +
Sbjct: 4124 CQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCE--DAAPNQY----------- 4170
Query: 1779 SDMAVSVPWYLGLA 1792
VS PW +GLA
Sbjct: 4171 ----VSTPWNIGLA 4180
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 465 bits (1196), Expect = e-130
Identities = 412/1483 (27%), Positives = 664/1483 (44%), Gaps = 147/1483 (9%)
Query: 323 PQFPQYNYQTLVPENEAAGTAV--LRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDP 380
P F Q Y + E+ A G+ V LR++ P V N + F I+
Sbjct: 2706 PSFTQSQYSFTIAEDTAIGSTVDTLRIL---PSQNVWFSTVNGERPENNKGGI--FVIEQ 2760
Query: 381 QSGLIRTAAALDRESMERHYLRVTAQ-DHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
++G I+ LDRE+ + +V A + T V + V D ND+ PVFE + Y
Sbjct: 2761 ETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYD 2820
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
+ E + G + Q+RA D D N + Y + + AF ID +G IST
Sbjct: 2821 TIIMEGMPVGTKLTQVRAIDMDWGANGQVTYS-LHSDSQPEKVMEAFNIDSNTGWISTLK 2879
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVR 559
+D E ++ V ASD G E S+T V + V D NDNAP F+++ Y V+E
Sbjct: 2880 DLDHETDPTFTFSVVASDLG-EAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP 2938
Query: 560 PHTVVLRVTATDRD-KDANGLVHYNIISGNSRGHFAIDSLTGE--IQVVAPLDFEAEREY 616
P VV ++ DRD D N V Y+I GN RG FA+ + E + V PLD E + Y
Sbjct: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIY 2998
Query: 617 ALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAV 676
L I A D L + + V D+ND+ P+ + + E+ P ++ + A
Sbjct: 2999 FLNITATDG----LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAK 3054
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPL 736
DAD G N + YSL G + ++ F ++ +G + LDRE + Y +A D G
Sbjct: 3055 DADIGSNGYIRYSLYG-SGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGR-- 3111
Query: 737 SASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQIT 794
+++ + + DVNDN P F+ Y+ + E+ A + V AVD D N + Y +
Sbjct: 3112 FCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLA 3171
Query: 795 GGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA----LHDHCYVHINITD 850
+ F+I + G+ + L PLD +Q+ + + + A+D++ L V I + D
Sbjct: 3172 D-SAGGVFSIDSSSGI--IILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLD 3228
Query: 851 ANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FRIDA 908
N + PVF+ Y V+V ED G+ ++ + A+ D+G NA ITYL+ Q F+I+
Sbjct: 3229 INDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINP 3288
Query: 909 DSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTG 968
+G I++ LDYE + L + A+D G P + V + + DVNDN P+F Y+
Sbjct: 3289 KTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSA 3348
Query: 969 LVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDRE 1028
++SEDA SV+ + A D D+ NG++ ++ NG D D +FT++P G+V+ ++LDRE
Sbjct: 3349 VISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNG-DRDNEFTVDPVLGLVKVKKKLDRE 3407
Query: 1029 AVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQ 1088
VS Y L AVD G+P + + ++ + + DVNDN+PVF + ++EN VG+ + Q
Sbjct: 3408 RVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQ 3467
Query: 1089 ITAVDPDEGPNA-HIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA 1147
+ D D N + I+ GN E F +D G L + + + EYV+ VQA +
Sbjct: 3468 LVVTDRDSFHNGPPFSFSILSGNEEEEFVLDP-HGILRSAVVFQHTESLEYVLCVQAKDS 3526
Query: 1148 ---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSD 1204
VS + VR+++++ + P +I ++ D FP G+IG+I A D D+ D
Sbjct: 3527 GKPQQVSHTYIRVRVIEESTHKPTAIPLEI----FIVTMEDDFPGGVIGKIHATDQDMYD 3582
Query: 1205 HLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVV 1264
L ++ + + L VN G++ LD+ + + + V+V+DG V V+ V
Sbjct: 3583 VLTFAL-KSEQKSLFKVNSHDGKIIALGGLDSGKYV---LNVSVSDGRFQVPIDVVVHVE 3638
Query: 1265 IITEELLANSLTVRLENMWQERFLSPLLGRFLEGVA-AVLATPAEDVFIFNIQNDTDVGG 1323
+ E+L N++T+R EN+ E F+ + F + AVL + + I +IQ V G
Sbjct: 3639 QLVHEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLRNAVLTQKQDSLRIISIQ---PVAG 3695
Query: 1324 T-VLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFD---DNVC 1379
T L++ F A SSE + +++ + A R L +++ + C
Sbjct: 3696 TNQLDMLF------------AVEMHSSEFYKPAYLIQKLSNARRHLENIMRISAILEKNC 3743
Query: 1380 LREPCENYMKCVSVLRFDSSAPFLASASTL-FRPIQPIAGLRCRCPPGFTGDFCETELDL 1438
C+ C L DS A S + + F + +RC C G C D
Sbjct: 3744 SGLDCQE-QHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTC----NGGLCPGSNDP 3798
Query: 1439 CYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGF 1498
C PC C Y RP F
Sbjct: 3799 CVEKPCPGDMQCV----SYEASRRP----------------------------------F 3820
Query: 1499 RCQCPAGGAFEGPRCEVAARSFPPSSFVMFR----GLRQRFHLTLSLSFATVQQSGLLFY 1554
CQCP G G + SF +S++ +R + F L L L T+Q +G++ Y
Sbjct: 3821 LCQCPPGKL--GECSGHTSLSFAGNSYIKYRLSENSKEEDFKLALRL--RTLQSNGIIMY 3876
Query: 1555 NGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPG-GLSDGQWHTVHLRYYNKPRT 1613
+ + L++V G++ G ++ + G ++DG WH+V L N+ T
Sbjct: 3877 ----TRANPCIILKIVDGKLWFQLDCGSGPGILG--ISGRAVNDGSWHSVFLE-LNRNFT 3929
Query: 1614 DALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSL-DLTGPLL 1672
+L + + A L ++ FGA VQ + +SL D +
Sbjct: 3930 -SLSLDDSYVERRRAPLYFQTLSTESSIYFGAL----------VQADNIRSLTDTRVTQV 3978
Query: 1673 LGGVPNLPENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCK 1732
L G ++ +++ +L + +R A V GC C PC+
Sbjct: 3979 LSGFQGCLDSVILNN-------NELPLQNKRSSFAEVVGLTELKLGCVLYPDACKRSPCQ 4031
Query: 1733 NSGFCSE-RWGSFSCDCPVGFGGKDC--QLTMAHPHHFRGNGT 1772
+ G C+ G + C C F G++C ++T P+ R G+
Sbjct: 4032 HGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGS 4074
Score = 404 bits (1038), Expect = e-112
Identities = 296/967 (30%), Positives = 478/967 (49%), Gaps = 59/967 (6%)
Query: 319 ANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
AN H P F Y+ V E+ A G+AVL+V A D D GE L+Y++ A + +F
Sbjct: 1559 ANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEA---GNTGNMFK 1615
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
I+P G+I D +M + L + D GSP +SAT +V ++V ++ P F
Sbjct: 1616 IEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKD 1675
Query: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Y+ + ENV+ G ++ + A + L Y F I+P SG+I+T
Sbjct: 1676 YQAEVNENVDIGTSVILISAIS-----QSTLIYE-----VKDGDINGIFTINPYSGVITT 1725
Query: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
+D E SY+L+++A++ ++ V+I ++DENDNAP F +Y + E
Sbjct: 1726 QKALDYERTSSYQLIIQATNM----AGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEA 1781
Query: 558 VRPHTVV-------LRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
+++V L + ATD D + N L+ Y I+ ++ F +DS TG I+ +A LD
Sbjct: 1782 APINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDH 1841
Query: 611 EAEREYALRIRAQDAGRPPLSNNTGL-ASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
E + + +D+G P L+ + + +I+V D+ND+ P+F F+ +L +G
Sbjct: 1842 ETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVE 1901
Query: 670 VIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEAR 729
V+ + A D D L YSL + D F+I+S +G +++ + S +HY V+
Sbjct: 1902 VLKVSATDPDSEVPPELTYSLMEGSLD-HFLIDSNSGVLTIKN--NNLSKDHYMLIVKVS 1958
Query: 730 DHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAI 789
D +++ VT+ V + D+ FT Y ++E+ T V V AV N +
Sbjct: 1959 D---GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPL 2015
Query: 790 SYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALH---DHCYVHI 846
Y I N N+F I + GV + T +P D +++ ++LV+ AS H V +
Sbjct: 2016 KYSIL--NPGNKFKIKSTSGV-IQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRV 2072
Query: 847 NITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRI 906
NI D N + PVF Y +V D G+ I ++A D D G N +TY+L+D+ F I
Sbjct: 2073 NIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEI 2132
Query: 907 DADSGAITLQAPLDYE-DQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
+ +SG + L+ + + + Y + I A+D G P +T VE+ + VN P F
Sbjct: 2133 NPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSL--STSVELPITIVNKAMPVFDKPF 2190
Query: 966 YTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRL 1025
YT V+ED T +L I+AT + + Y +G D F I+ +G+++ V L
Sbjct: 2191 YTASVNEDIRMNTPILSINATSPEGQG---IIYIIIDG-DPFKQFNIDFDTGVLKVVSPL 2246
Query: 1026 DREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSV 1085
D E S Y+LT A D + R V++ ++V DVNDN P+F + + E S++G+
Sbjct: 2247 DYEVTSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTP 2305
Query: 1086 VAQITAVDPDEGPNAHIMYQIVEG--NIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143
V Q+ ++D D N + YQIV+ N + F +D SG + LD+E Q + V+
Sbjct: 2306 VLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVR 2365
Query: 1144 ATSA---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYD 1199
+ + L S VH+ + D NDN PV N Q+++ +YV S+ P G + + A D
Sbjct: 2366 SIDSGFPSLSSEVLVHIYISDVNDNPPVFN--QLIYESYV---SELAPRGHFVTCVQASD 2420
Query: 1200 PDVS--DHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTA 1257
D S D L YS GN+ +++ SG + LS + S+ V+V+DGL + TA
Sbjct: 2421 ADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTA 2480
Query: 1258 QCVLRVV 1264
Q +RV+
Sbjct: 2481 QVHIRVL 2487
Score = 376 bits (965), Expect = e-103
Identities = 304/972 (31%), Positives = 467/972 (48%), Gaps = 71/972 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P FP + V EN GT+VL+V A+D D+G G + YS+ + L FSID +S
Sbjct: 1041 PYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIR---DGSGLGRFSIDDES 1097
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
G+I A LDRE+M ++L V A D G L +T V + V D ND++P+ + Y +
Sbjct: 1098 GVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVV 1157
Query: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFV-GPPAARAAAAAAFEIDPRSGLISTSGR- 500
EN + ++Q++A D D+ N L YR G P F I+ ++GLI+T+ R
Sbjct: 1158 MENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNP------QNFFAINIKTGLITTTSRK 1211
Query: 501 VDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV--REDV 558
+DRE + L V +D G P P+ +T+ V + VLDENDN PQF EK Y ++ R+
Sbjct: 1212 LDREQQAEHFLEVTVTDGG--PSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRK 1269
Query: 559 RPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYAL 618
+ + R A DRD+ N + Y+I+ GN G F ID TG V + F A L
Sbjct: 1270 KRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTG--MVSSRKQFTAGSYDIL 1327
Query: 619 RIRAQDAGRPPLSNNTGLASIQVVDIN----DHIPIFVSTPF-QVSVLENAPLGHSVIHI 673
I+A D GRP S+ A + + I IP+ PF +V+E+ V I
Sbjct: 1328 TIKAVDNGRPQKSST---ARLHIEWIKKPPPSPIPLTFDEPFYNFTVMES----DRVTEI 1380
Query: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGS 733
V + N L + + G D+ F G + ++ PLD E Y VE D +
Sbjct: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
Query: 734 PPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQI 793
A V + VLD NDN PEF+ Y + ++ED T ++ + A DRD +SY +
Sbjct: 1441 ---VAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTV 1497
Query: 794 ---TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRAL---HDHCYVHIN 847
+ +F I GV + A LD++ + L + D+ + V +N
Sbjct: 1498 HSSIDSISMRKFRIDPSTGV--LYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVN 1555
Query: 848 ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLPQFR 905
+ DAN H P F + Y SV E +GS ++ ++A D D GENA + Y +E + F+
Sbjct: 1556 VEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFK 1615
Query: 906 IDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
I+ G IT+ D + L+I D G P + T V + V +++ P+F+
Sbjct: 1616 IEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKD 1675
Query: 966 YTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRL 1025
Y V+E+ TSV+ ISA + + Y ++G D +G FTI P SG++ T + L
Sbjct: 1676 YQAEVNENVDIGTSVILISAISQST-----LIYEVKDG-DINGIFTINPYSGVITTQKAL 1729
Query: 1026 DREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSV 1085
D E S Y+L A + V+IQ++ D NDNAPVF ++ + E + + S+
Sbjct: 1730 DYERTSSYQLIIQATNMAGMASNATVNIQIV--DENDNAPVFLFSQYSGSLSEAAPINSI 1787
Query: 1086 VAQ-------ITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYE--ARQ 1136
V I A D D NA ++YQIVE + F +D +G + + +LD+E A
Sbjct: 1788 VRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHF 1847
Query: 1137 EYVIVVQATSAPLV---SRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIG 1193
+ + V+ + +P + S V++ + D NDN PV Q +F + T+ +
Sbjct: 1848 HFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFT--QAVFETIL--LLPTYVGVEVL 1903
Query: 1194 RIPAYDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG 1251
++ A DPD V L YS G+ L +++ SG L + K +N ++V V+DG
Sbjct: 1904 KVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTI--KNNNLSKDHYMLIVKVSDG 1960
Query: 1252 LHSVTAQCVLRV 1263
T+ + V
Sbjct: 1961 KFYSTSMVTIMV 1972
Score = 367 bits (943), Expect = e-101
Identities = 290/980 (29%), Positives = 447/980 (45%), Gaps = 70/980 (7%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + P F Q +Y + E+ GT +++V A+D D G G + YS+ + F+
Sbjct: 824 ANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLT-----DTQQFA 878
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQD--HGSPRLSATTMVAVTVADRNDHSPVFEQ 435
I+ +G++ A LDRES + L++ A+D +L + + V + D ND SP F
Sbjct: 879 INSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIP 938
Query: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
+ Y + E++ G I L D D +RY V R FEID SG I
Sbjct: 939 SSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR------FEIDKASGAI 992
Query: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDN--APQFSEKRYVAQ 553
S +D E + Y L V A D+G+ P S+ V + V+D N+N P F + V
Sbjct: 993 RLSKELDYEKQQFYNLTVRAKDKGR-PVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGS 1051
Query: 554 VREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAE 613
V+E+ R T VL+VTA D D +G + Y+I G+ G F+ID +G I LD E
Sbjct: 1052 VKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETM 1111
Query: 614 REYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673
Y L + A D G PL +T I+V D+ND+ P+ + V+EN+P SVI I
Sbjct: 1112 GSYWLTVYATDRGVVPL-YSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI 1170
Query: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWV-SVSGPLDRESVEHYFFGVEARDHG 732
QA D D N +L Y +T P F IN TG + + S LDRE +F V D G
Sbjct: 1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
Query: 733 SPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNE--DAAVGTSVVSVTAVDRD--ANSA 788
P ++ V V VLD NDN+P+F K Y ++L E G + A DRD N+
Sbjct: 1231 PSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAE 1290
Query: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVH 845
ISY I GN +F I + G+ ++ + Y L + A D +H
Sbjct: 1291 ISYSIVDGNDDGKFFIDPKTGM----VSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLH 1346
Query: 846 INITDANTHRPV---FQSAHYSVSVNEDRPMGSTIVVISASD-------DDVGENARITY 895
I P+ F Y+ +V E + + V+S D VG N +
Sbjct: 1347 IEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAF 1406
Query: 896 LLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVN 955
E + G I + PLD E + Y +++ D T V + V D N
Sbjct: 1407 DAEKGV---------GTIVIAKPLDAEQRSIYNMSVEVTDG---TNVAVTQVFIKVLDNN 1454
Query: 956 DNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDG--DFTIE 1013
DN P+F +Y +SED P T +LQI ATDRD ++ YT + D F I+
Sbjct: 1455 DNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMRKFRID 1512
Query: 1014 PTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFE 1073
P++G++ T RLD EA + L D+ P R + V V+D ND++P F +E
Sbjct: 1513 PSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYE 1572
Query: 1074 VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYE 1133
V E++ +GS V Q+TA+D D+G NA ++Y I GN +F+++ G +T + D
Sbjct: 1573 ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMT 1632
Query: 1134 ARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNSP--VLNNFQILFNNYVSNRSDTFP 1188
++V+ ++ T S P+ + A V + + +++ P + ++Q N V +
Sbjct: 1633 TMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL 1692
Query: 1189 SGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTV 1248
I + L Y + G+ + +N SG + + LD R +++
Sbjct: 1693 ISAISQ---------STLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQA 1743
Query: 1249 TDGLHSVTAQCVLRVVIITE 1268
T+ + + + + + I+ E
Sbjct: 1744 TN-MAGMASNATVNIQIVDE 1762
Score = 365 bits (938), Expect = e-100
Identities = 275/852 (32%), Positives = 416/852 (48%), Gaps = 79/852 (9%)
Query: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
F I+P+SGLI TA L+ E + L VT ++ V +++ D NDH+P F+Q
Sbjct: 420 FKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQVTISIEDANDHTPEFQQ 474
Query: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Y + E+V G +L + A+D D N + Y + F I+ +G+I
Sbjct: 475 PLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIA------SLNLLPFVINQFTGVI 528
Query: 496 STSGRVDREHM-ESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
ST+ +D E E Y +V ASD G P + V V I + + NDN+P F + +
Sbjct: 529 STTEELDFESSPEIYRFIVRASDWGS-PYRHESEVNVTIRIGNVNDNSPLFEKVACQGVI 587
Query: 555 REDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAER 614
D + V+A D D+ LV Y IISGN G F ++ +G +Q+ L +
Sbjct: 588 SYDFPVGGHITAVSAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIK 645
Query: 615 E--YALRIRAQDAGR--PPLSNNTGLASIQV----------------------------- 641
+ALRI A D P+S N + +V
Sbjct: 646 NGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGK 705
Query: 642 ----------VDINDHIPIF-VSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL 690
IN P F S P V+V E+ P+G +++ I+A DAD G N ++ +++
Sbjct: 706 LNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTI 765
Query: 691 TGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVN 750
+ D+ F I+ TG + V P+DRE + Y + D G+P S+ +T+ V D N
Sbjct: 766 SDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDAN 825
Query: 751 DNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQG 808
DN P F Y + + E + +GT ++ V A D+D +N ++Y + +FAI++
Sbjct: 826 DNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINS-- 881
Query: 809 GVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHINITDANTHRPVFQSAHY 863
G+V +A LD + + + L + A D+A L + + + D N P F + Y
Sbjct: 882 STGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSY 941
Query: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDNLPQFRIDADSGAITLQAPLDYE 922
SV V ED P+G+ I + D D+G ++ Y L+ D +F ID SGAI L LDYE
Sbjct: 942 SVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYE 1001
Query: 923 DQVTYTLAITARDNGIP-QKADTTYVEVMVNDVNDN--APQFVASHYTGLVSEDAPPFTS 979
Q Y L + A+D G P + ++VEV V DVN+N P F G V E++ TS
Sbjct: 1002 KQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTS 1061
Query: 980 VLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA 1039
VLQ++A D D+ +G +QY+ ++G G G F+I+ SG++ LDRE + Y LT YA
Sbjct: 1062 VLQVTARDEDSGRDGEIQYSIRDG-SGLGRFSIDDESGVITAADILDRETMGSYWLTVYA 1120
Query: 1040 VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPN 1099
DRGV PL + + + + V+DVNDNAP+ + V ENS V QI A DPD N
Sbjct: 1121 TDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSN 1180
Query: 1100 AHIMYQIVEGNIPELFQMDIFSGELTALI-DLDYEARQEYVIVVQATS---APLVSRATV 1155
+ Y+I GN F ++I +G +T LD E + E+ + V T +P S V
Sbjct: 1181 EKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWV 1240
Query: 1156 HVRLVDQNDNSP 1167
V+++D+NDN P
Sbjct: 1241 VVQVLDENDNKP 1252
Score = 362 bits (930), Expect = 3e-99
Identities = 301/1017 (29%), Positives = 476/1017 (46%), Gaps = 101/1017 (9%)
Query: 319 ANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
AN H P+F Q Y V E+ GT+VL V A D D GE G + YS+A+L +L F
Sbjct: 465 ANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASL----NLLPFV 520
Query: 378 IDPQSGLIRTAAALDRESMERHY-LRVTAQDHGSP-RLSATTMVAVTVADRNDHSPVFEQ 435
I+ +G+I T LD ES Y V A D GSP R + V + + + ND+SP+FE+
Sbjct: 521 INQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEK 580
Query: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
+ + + G I + A D D ++Y+ + F ++P SG++
Sbjct: 581 VACQGVISYDFPVGGHITAVSAIDID--ELELVKYKIIS-----GNELGFFYLNPDSGVL 633
Query: 496 STSGRVDREHME--SYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFS-EKRYVA 552
+ ++ ++ L + A+D P S ++I+VL ++ FS + VA
Sbjct: 634 QLKKSLTNSGIKNGNFALRITATDGENLADPMS----INISVLHGKVSSKSFSCRETRVA 689
Query: 553 Q--------------------------------------------VREDVRPHTVVLRVT 568
Q V+ED+ +L++
Sbjct: 690 QKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIK 749
Query: 569 ATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRP 628
A D D NG V + I GN+ F ID TG+++V+ P+D E Y L I D G P
Sbjct: 750 AYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNP 809
Query: 629 PLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEY 688
S + L +I V D ND+ P+F+ + V++LE++ +G +I ++A D D G N + Y
Sbjct: 810 QKS-SWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTY 868
Query: 689 SLTGVAPDT-PFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVL 747
S V DT F INS+TG V V+ LDRES +Y +EARD + VT+ V
Sbjct: 869 S---VLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVF 925
Query: 748 --DVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFA 803
DVND P F Y +++ ED VGT + + D D + Y + + RF
Sbjct: 926 LDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFE 984
Query: 804 ISTQGGVGLVTLALPLDYKQERYFKLVLTASDR----ALHDHCYVHINITDA--NTHRPV 857
I G + L+ LDY++++++ L + A D+ +L +V + + D N H P
Sbjct: 985 IDKASGA--IRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPY 1042
Query: 858 FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED--NLPQFRIDADSGAITL 915
F SV E+ +G++++ ++A D+D G + I Y + D L +F ID +SG IT
Sbjct: 1043 FPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITA 1102
Query: 916 QAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAP 975
LD E +Y L + A D G+ T V + V DVNDNAP Y +V E++P
Sbjct: 1103 ADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSP 1162
Query: 976 PFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV-RRLDREAVSVYE 1034
SV+QI A D D+ +N ++ Y +G + F I +G++ T R+LDRE + +
Sbjct: 1163 KDVSVIQIQAEDPDSSSNEKLTYRITSG-NPQNFFAINIKTGLITTTSRKLDREQQAEHF 1221
Query: 1035 LTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV--GSVVAQITAV 1092
L D G P ++ + + V V D NDN P FP + +++++ E G + + A
Sbjct: 1222 LEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAF 1281
Query: 1093 DPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS---APL 1149
D DEGPNA I Y IV+GN F +D +G +++ + A ++ ++A
Sbjct: 1282 DRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSS--RKQFTAGSYDILTIKAVDNGRPQK 1339
Query: 1150 VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSD--TFPSGIIGRIPAYDPDVSDHLF 1207
S A +H+ + + SP+ F F N+ SD T G++ PA P L+
Sbjct: 1340 SSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP-----LW 1394
Query: 1208 YSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVV 1264
+ GN + G + +++ LD + + +M V VTDG + Q ++V+
Sbjct: 1395 FDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVL 1451
Score = 339 bits (869), Expect = 3e-92
Identities = 283/958 (29%), Positives = 449/958 (46%), Gaps = 62/958 (6%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F Q Y++ V E G V V A D D+ + RL YS+ ++ F +D +S
Sbjct: 2392 PVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSI---LSGNDRTSFLMDSKS 2448
Query: 383 GLIRTAAALDRESMERHY-LRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
G+I T + ++ ME Y L V+ D ++T V + V N +SP F Q+ Y
Sbjct: 2449 GVI-TLSNHRKQRMEPLYSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVAE 2504
Query: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
+RENV G ++ +RATDGD + Y + A F ID +G + T+ R+
Sbjct: 2505 VRENVAAGTKVIHVRATDGDPGTYGQISYAIIND-----FAKDRFLIDS-NGQVITTERL 2558
Query: 502 DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561
DRE+ E V + + G R+ V + V+DENDNAPQF Y A VR DV
Sbjct: 2559 DREN--PLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRG 2616
Query: 562 TVVLRVTATDRDKDANGLVHYNIISGNS---RGHFAIDSLTGEIQVVAPLDFEAEREYAL 618
+V +V A D D AN + Y++ S S ID G + + +
Sbjct: 2617 HLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSF 2676
Query: 619 RIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDA 678
++A D G P+ ++ I V+ +P F + + ++ E+ +G +V ++ + +
Sbjct: 2677 FVKAVDGG-IPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPS 2735
Query: 679 DH-----GENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEAR-DHG 732
+ R E + G+ FVI TG + + LDRE+ + F V A
Sbjct: 2736 QNVWFSTVNGERPENNKGGI-----FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
Query: 733 SPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAIS 790
+ + V + VLD+NDN+P F Y + E VGT + V A+D D AN ++
Sbjct: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
Query: 791 YQITGGNTRNRF--AISTQGGVGLVTLALPLDYKQERYFKLVLTASDR----ALHDHCYV 844
Y + + + A + G ++ LD++ + F + ASD +L V
Sbjct: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALV 2910
Query: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGE-NARITYLLEDNLPQ 903
+ +TD N + PVF Y +V E P G + V+S D D + N +++Y + P+
Sbjct: 2911 SVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPR 2970
Query: 904 FR----IDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAP 959
R + + ++ PLD E+Q Y L ITA D +A VEV V+DVNDN+P
Sbjct: 2971 GRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQA---MVEVSVSDVNDNSP 3027
Query: 960 QFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIV 1019
YT L+ ED P +L++SA D D +NG ++Y+ G+ +F ++P SG +
Sbjct: 3028 VCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYG--SGNSEFFLDPESGEL 3085
Query: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
+T+ LDRE + VY L A A D G ++ +I ++++DVNDN PVF ++ + V EN
Sbjct: 3086 KTLALLDRERIPVYSLMAKATDGGGRFCQS--NIHLILEDVNDNPPVFSSDHYNTCVYEN 3143
Query: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV 1139
+ +++ ++ AVDPD G N ++Y + + + +F +D SG + LD E + Y
Sbjct: 3144 TATKALLTRVQAVDPDIGINRKVVYSLAD-SAGGVFSIDSSSGIIILEQPLDREQQSSYN 3202
Query: 1140 IVVQAT----SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRI 1195
I V+AT L S TV + ++D NDN PV L V+ DT P + +
Sbjct: 3203 ISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYL----VTVPEDTSPGTQVLAV 3258
Query: 1196 PAYDPDVSDH--LFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG 1251
A D+ + + Y GNE +N +G + +S LD ++V DG
Sbjct: 3259 FATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDG 3316
Score = 332 bits (850), Expect = 5e-90
Identities = 257/956 (26%), Positives = 456/956 (47%), Gaps = 53/956 (5%)
Query: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
V E+ G +L++ A D D+G G+++++++ + + F+ID ++G ++ +DR
Sbjct: 735 VKEDLPVGANILKIKAYDADSGFNGKVLFTIS---DGNTDSCFNIDMETGQLKVLMPMDR 791
Query: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL 453
E + + L +T D G+P+ S+ ++ + V D ND+SPVF Q Y + E+ G I+
Sbjct: 792 EHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEII 851
Query: 454 QLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVV 513
Q+ A D D N + Y + F I+ +G++ + ++DRE +Y L +
Sbjct: 852 QVEARDKDLGSNGEVTYSVL-------TDTQQFAINSSTGIVYVADQLDRESKANYSLKI 904
Query: 514 EASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRD 573
EA D+ + + V + + + D ND +P F Y +V ED+ TV+ + D D
Sbjct: 905 EARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPD 964
Query: 574 KDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNN 633
G V Y++++ + G F ID +G I++ LD+E ++ Y L +RA+D GRP ++
Sbjct: 965 LGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSS 1023
Query: 634 TGLASIQVVDIND--HIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLT 691
++VVD+N+ H P F SV EN+ +G SV+ + A D D G + ++YS+
Sbjct: 1024 VSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIR 1083
Query: 692 GVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVND 751
+ F I+ +G ++ + LDRE++ Y+ V A D G PL ++ V + V DVND
Sbjct: 1084 DGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVND 1143
Query: 752 NRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGG 809
N P + Y+ + E++ SV+ + A D D +N ++Y+IT GN +N FAI+ + G
Sbjct: 1144 NAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTG 1203
Query: 810 VGLVTLALPLDYKQERYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQSAHYSVS 866
+ + T + LD +Q+ L +T +D +V + + D N ++P F Y +
Sbjct: 1204 L-ITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIK 1262
Query: 867 VNE--DRPMGSTIVVISASDDDVGENARITYLLEDNLP--QFRIDADSGAITLQAPLDYE 922
+ E + G I A D D G NA I+Y + D +F ID +G ++ + +
Sbjct: 1263 LPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFT 1320
Query: 923 DQVTYTLAITARDNGIPQKADTT--YVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSV 980
L I A DNG PQK+ T ++E + P + ++ T +
Sbjct: 1321 AGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
Query: 981 LQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV 1040
+ + + AN + + G + D F E G + + LD E S+Y ++
Sbjct: 1381 VGVVSVQ---PANTPLWFDIVGG-NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVT 1436
Query: 1041 DRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPN- 1099
D G T V I+V+ D NDN P F ++V + E+ + + + QI A D DE
Sbjct: 1437 D-GTNVAVTQVFIKVL--DNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKL 1493
Query: 1100 AHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVH 1156
++ ++ ++ F++D +G L LD+EA+ ++++ + R A V
Sbjct: 1494 SYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVI 1553
Query: 1157 VRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIG----RIPAYDPDVSDH--LFYSF 1210
V + D ND+SP N + F S +G ++ A D D ++ L Y+
Sbjct: 1554 VNVEDANDHSPYFTN--------PLYEASVFESAALGSAVLQVTALDKDKGENAELIYTI 1605
Query: 1211 ERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD-GLHSVTAQCVLRVVI 1265
E GN + + G + + ++ D + + VTD G ++A ++R+ +
Sbjct: 1606 EAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
Score = 332 bits (850), Expect = 5e-90
Identities = 266/938 (28%), Positives = 449/938 (47%), Gaps = 64/938 (6%)
Query: 323 PQFPQYNYQTLVPENEAA--GTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDP 380
PQFP+ YQ +PE + G + R A D D G + YS+ ++ F IDP
Sbjct: 1252 PQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSI---VDGNDDGKFFIDP 1308
Query: 381 QSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPV---FEQAQ 437
++G++ + S + L + A D+G P+ S+T + + + SP+ F++
Sbjct: 1309 KTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPF 1366
Query: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Y T+ E+ + ++ P N L + VG +AF+ + G I
Sbjct: 1367 YNFTVMESDR----VTEIVGVVSVQPANTPLWFDIVG-----GNFDSAFDAEKGVGTIVI 1417
Query: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
+ +D E Y + VE +D G A +V I VLD NDN P+FS+ Y + ED
Sbjct: 1418 AKPLDAEQRSIYNMSVEVTD-----GTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISED 1472
Query: 558 VRPHTVVLRVTATDRDKD--ANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE 615
V P T +L++ ATDRD+ + VH +I S + R F ID TG + LD EA+ +
Sbjct: 1473 VLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMR-KFRIDPSTGVLYTAERLDHEAQDK 1531
Query: 616 YALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQA 675
+ L I +D P N + V D NDH P F + ++ SV E+A LG +V+ + A
Sbjct: 1532 HILNIMVRDQ-EFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
Query: 676 VDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP 735
+D D GENA L Y++ F I G +++ D ++ + ++ D GSPP
Sbjct: 1591 LDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPP 1650
Query: 736 LSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITG 795
+SA+A V ++V +++ P+F K+Y +NE+ +GTSV+ ++A+ + S + Y++
Sbjct: 1651 MSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI---SQSTLIYEVKD 1707
Query: 796 GNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHINITDANTH 854
G+ F I+ GV +T LDY++ ++L++ A++ A + + V+I I D N +
Sbjct: 1708 GDINGIFTINPYSGV--ITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDN 1765
Query: 855 RPVFQSAHYSVSVNEDRPMGSTI-------VVISASDDDVGENARITYLLEDNLPQ--FR 905
PVF + YS S++E P+ S + +VI A+D D NA + Y + ++ + F
Sbjct: 1766 APVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFT 1825
Query: 906 IDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEV--MVNDVNDNAPQFVA 963
+D+ +GAI A LD+E + + RD+G PQ + VEV V DVNDN P F
Sbjct: 1826 VDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQ 1885
Query: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR 1023
+ + ++ VL++SATD D+ + Y+ G F I+ SG++ T++
Sbjct: 1886 AVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEG--SLDHFLIDSNSGVL-TIK 1942
Query: 1024 RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVG 1083
+ + Y L D + + +MV++ D+ F + + EN+
Sbjct: 1943 N-NNLSKDHYMLIVKVSD---GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNI 1998
Query: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGEL-TALIDLDYEARQEYVIVV 1142
+ VA + AV N + Y I+ N F++ SG + T + D E ++ Y +VV
Sbjct: 1999 TKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVV 2054
Query: 1143 QAT---SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYD 1199
+A+ V+R V V + D NDNSPV + Y + + D P +I ++ A D
Sbjct: 2055 EASRELDHLRVARVVVRVNIEDINDNSPVF----VGLPYYAAVQVDAEPGTLIYQVTAID 2110
Query: 1200 PDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNN 1237
D + ++ ++ +N SG + L +++
Sbjct: 2111 KDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSD 2148
Score = 330 bits (847), Expect = 1e-89
Identities = 289/979 (29%), Positives = 439/979 (44%), Gaps = 57/979 (5%)
Query: 308 TSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAAL 367
T+ R + N HP+F +YQ V EN GT+V+ + A L+Y +
Sbjct: 1654 TAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVK-- 1706
Query: 368 MNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ +F+I+P SG+I T ALD E + L + A + +AT V + + D N
Sbjct: 1707 -DGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNAT--VNIQIVDEN 1763
Query: 428 DHSPVFEQAQYRETLRENVEEGYPI-------LQLRATDGDAPPNANLRYRFVGPPAARA 480
D++PVF +QY +L E + L +RATD D+ NA L Y+ V +
Sbjct: 1764 DNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV-----ES 1818
Query: 481 AAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEND 540
A F +D +G I T +D E + + V D G + V V+I V D ND
Sbjct: 1819 TAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVND 1878
Query: 541 NAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTG 600
N P F++ + + VL+V+ATD D + + Y+++ G S HF IDS +G
Sbjct: 1879 NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEG-SLDHFLIDSNSG 1937
Query: 601 EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSV 660
+ + + ++ Y L ++ D +T + +I V + D F + + S+
Sbjct: 1938 VLTIKN--NNLSKDHYMLIVKVSDGK----FYSTSMVTIMVKEAMDSGLHFTQSFYSTSI 1991
Query: 661 LENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSG-PLDRESV 719
EN V + AV + N L+YS+ P F I S +G + +G P DRE
Sbjct: 1992 SENNTNITKVAIVNAVG--NRLNEPLKYSILN--PGNKFKIKSTSGVIQTTGVPFDREEQ 2047
Query: 720 EHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVT 779
E Y VEA A V V + D+NDN P F Y+ + DA GT + VT
Sbjct: 2048 ELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVT 2107
Query: 780 AVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA 837
A+D+D N ++Y + + F I+ G ++ A D Y +L
Sbjct: 2108 AIDKDKGPNGEVTYVLQ--DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGK 2165
Query: 838 LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL 897
V + IT N PVF Y+ SVNED M + I+ I+A+ E I Y++
Sbjct: 2166 PSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP---EGQGIIYII 2222
Query: 898 EDNLP--QFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVN 955
D P QF ID D+G + + +PLDYE Y L I A D +A+ T V+++VNDVN
Sbjct: 2223 IDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVT-VDLLVNDVN 2281
Query: 956 DNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTF-QNGEDGDGDFTIEP 1014
DN P F Y +SE + T VLQ+ + D D+ N V Y Q+ + F I+
Sbjct: 2282 DNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDS 2341
Query: 1015 TSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEV 1074
+SG++ T R LD E V L ++D G P L + V + + + DVNDN PVF +E
Sbjct: 2342 SSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYES 2401
Query: 1075 RVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA 1134
V E + G V + A D D + Y I+ GN F MD SG +T
Sbjct: 2402 YVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRM 2461
Query: 1135 RQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG---I 1191
Y + V + S A VH+R++ N SP + + YV+ + +G I
Sbjct: 2462 EPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQ-----STYVAEVRENVAAGTKVI 2516
Query: 1192 IGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLV--ASMLVTVT 1249
R DP + Y+ +++ ++G++ + +LD PL S+ V
Sbjct: 2517 HVRATDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPLEGDVSIFVRAL 2575
Query: 1250 DGLHSVTAQCVLRVVIITE 1268
DG T C +RV+++ E
Sbjct: 2576 DG-GGRTTFCTVRVIVVDE 2593
Score = 321 bits (822), Expect = 9e-87
Identities = 275/949 (28%), Positives = 435/949 (45%), Gaps = 91/949 (9%)
Query: 385 IRTAAALDRESMERHY-LRVTAQDHGSPRLSATTMVAVTVADRNDHSPV-FEQAQYRETL 442
I+ +D ES Y L + A+D GSP+ + D P+ FE+ Y ++
Sbjct: 326 IKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSI 385
Query: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
E G + ++ + P ++ Y+ + A F+I+PRSGLI T+ ++
Sbjct: 386 SEFSPPGVVVAIVKLS----PEPIDVEYKL-----SPGEDAVYFKINPRSGLIVTARPLN 436
Query: 503 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
E Y+L V + + +V I++ D ND+ P+F + Y A V E V T
Sbjct: 437 TVKKEVYKLEVTNKEGDLK-------AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGT 489
Query: 563 VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE-YALRIR 621
VL V+A+D+DK NG + Y+I S N F I+ TG I LDFE+ E Y +R
Sbjct: 490 SVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVISTTEELDFESSPEIYRFIVR 548
Query: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
A D G P + +I++ ++ND+ P+F Q + + P+G + + A+D D
Sbjct: 549 ASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDEL 608
Query: 682 ENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASAS 741
E ++Y + F +N +G + + L +++ F + L+ S
Sbjct: 609 E--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMS 666
Query: 742 VTVTVLDVNDNRPEFTMKEYHL----------------RLN------------------- 766
+ ++VL + F+ +E + +LN
Sbjct: 667 INISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFD 726
Query: 767 ----------EDAAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVT 814
ED VG +++ + A D D+ N + + I+ GNT + F I + G +
Sbjct: 727 KSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLK 784
Query: 815 LALPLDYKQERYFKLVLTASDRALHDHC---YVHINITDANTHRPVFQSAHYSVSVNEDR 871
+ +P+D + + L +T D + IN+ DAN + PVF YSV++ E
Sbjct: 785 VLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESS 844
Query: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
+G+ I+ + A D D+G N +TY + + QF I++ +G + + LD E + Y+L I
Sbjct: 845 GIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKI 904
Query: 932 TARDNGIP--QKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRD 989
ARD Q ++V ++DVND +P F+ S Y+ V ED P T + + D D
Sbjct: 905 EARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPD 964
Query: 990 AHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRT 1049
G+V+Y+ N D +G F I+ SG +R + LD E Y LT A D+G P +
Sbjct: 965 LGLGGQVRYSLVN--DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLS 1022
Query: 1050 PVS-IQVMVQDVNDN--APVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQI 1106
VS ++V V DVN+N P FP VKENS +G+ V Q+TA D D G + I Y I
Sbjct: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSI 1082
Query: 1107 VEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS---APLVSRATVHVRLVDQN 1163
+G+ F +D SG +TA LD E Y + V AT PL S V++ + D N
Sbjct: 1083 RDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVN 1142
Query: 1164 DNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDH--LFYSFERGNELQLLVV 1221
DN+P+ + + ++ V S S I +I A DPD S + L Y GN +
Sbjct: 1143 DNAPLTS--EPIYYPVVMENSPKDVSVI--QIQAEDPDSSSNEKLTYRITSGNPQNFFAI 1198
Query: 1222 NQTSGELRL-SRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVIITEE 1269
N +G + SRKLD + + VTVTDG S + VV + +E
Sbjct: 1199 NIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDE 1247
Score = 293 bits (750), Expect = 2e-78
Identities = 272/996 (27%), Positives = 431/996 (43%), Gaps = 103/996 (10%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F Y + E+ T+V +V A D D G G Y ++LFS+ P S
Sbjct: 156 PLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF-----KNKVDLFSVHPTS 210
Query: 383 GLIRTAAALDRESMERHYLRVTAQD-----HGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
G+I + L+ + R+ L + A D +G+ +S+T + V + N+H+P
Sbjct: 211 GVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT 270
Query: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPP------AARAAAAAAFEIDPR 491
+ E E Y ++ + D A G P A ++I R
Sbjct: 271 HVPFSLEK-EPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKER 329
Query: 492 SGLISTSGRVDREHME-SYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRY 550
++D E Y L ++A D+G P SA V+I + +F ++ Y
Sbjct: 330 K-------QIDWESFPYGYNLTLQAKDKG-SPQKCSALKAVYIGNPTRDTVPIRFEKEVY 381
Query: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
+ E P VV V + D V Y + G +F I+ +G I PL+
Sbjct: 382 DVSISEFSPPGVVVAIVKLSPEPID----VEYKLSPGEDAVYFKINPRSGLIVTARPLNT 437
Query: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
+ Y L + ++ + +I + D NDH P F + V E+ P+G SV
Sbjct: 438 VKKEVYKLEVTNKE------GDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSV 491
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRE-SVEHYFFGVEAR 729
+ + A D D GEN + YS+ + PFVIN TG +S + LD E S E Y F V A
Sbjct: 492 LTVSASDKDKGENGYITYSIASLNL-LPFVINQFTGVISTTEELDFESSPEIYRFIVRAS 550
Query: 730 DHGSPPLSAS-ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA 788
D GSP S +VT+ + +VNDN P F ++ D VG + +V+A+D D
Sbjct: 551 DWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELEL 610
Query: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD-RALHDHCYVHIN 847
+ Y+I GN F ++ GV + +L + F L +TA+D L D ++I+
Sbjct: 611 VKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINIS 670
Query: 848 IT--------------------------------------------DANTHRPVFQSAHY 863
+ N P F +
Sbjct: 671 VLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFP 730
Query: 864 S-VSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGAITLQAPLD 920
S V+V ED P+G+ I+ I A D D G N ++ + + D F ID ++G + + P+D
Sbjct: 731 SDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMD 790
Query: 921 YEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSV 980
E Y L IT D G PQK+ + + V D NDN+P F+ Y+ + E + T +
Sbjct: 791 REHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEI 850
Query: 981 LQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV 1040
+Q+ A D+D +NG V Y+ F I ++GIV +LDRE+ + Y L A
Sbjct: 851 IQVEARDKDLGSNGEVTYSVLTDTQ---QFAINSSTGIVYVADQLDRESKANYSLKIEAR 907
Query: 1041 DRGV--PPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGP 1098
D+ L + V+++V + DVND +P F + V+V E+ VG+V+A + DPD G
Sbjct: 908 DKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
Query: 1099 NAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS----APLVSRAT 1154
+ Y +V + F++D SG + +LDYE +Q Y + V+A L S +
Sbjct: 968 GGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSF 1026
Query: 1155 VHVRLVDQNDN--SPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFER 1212
V V +VD N+N +P +F ++ + ++R T + R D + YS
Sbjct: 1027 VEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAR--DEDSGRDGEIQYSIRD 1084
Query: 1213 GNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTV 1248
G+ L ++ SG + + LD R + S +TV
Sbjct: 1085 GSGLGRFSIDDESGVITAADILD--RETMGSYWLTV 1118
Score = 241 bits (615), Expect = 9e-63
Identities = 248/957 (25%), Positives = 419/957 (43%), Gaps = 106/957 (11%)
Query: 388 AAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVE 447
+A L+RE + + L V G L A T V + V D ND P+F Y T+ E+
Sbjct: 114 SAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTP 172
Query: 448 EGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHME 507
+ Q+ ATD D N Y F F + P SG+IS SGR++ +
Sbjct: 173 LRTSVAQVTATDADIGSNGEFYYYFKN-------KVDLFSVHPTSGVISLSGRLNYDEKN 225
Query: 508 SYELVVEASDQGQE---PGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVV 564
Y+L + A D+G + S+T ++++ + N++AP +V E + V
Sbjct: 226 RYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAV- 284
Query: 565 LRVTATDRDKDANGLVH-YNIISGNSRGHFAIDS-----LTGEIQVVAPLDFEA-EREYA 617
VT D D ANG + +I++G+ F + +I+ +D+E+ Y
Sbjct: 285 --VTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYN 342
Query: 618 LRIRAQDAGRPPLSNNTGLASIQVVD-INDHIPI-FVSTPFQVSVLENAPLGHSVIHIQA 675
L ++A+D G P + L ++ + + D +PI F + VS+ E +P G V A
Sbjct: 343 LTLQAKDKGSP--QKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVV----A 396
Query: 676 VDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP 735
+ E +EY L+ F IN +G + + PL+ E Y V ++
Sbjct: 397 IVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG---- 452
Query: 736 LSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQI 793
A VT+++ D ND+ PEF Y +NE VGTSV++V+A D+D N I+Y I
Sbjct: 453 -DLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI 511
Query: 794 TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRAL----HDHCYVHINIT 849
N F I+ GV T L + E Y + ++ ASD V I I
Sbjct: 512 ASLNLL-PFVINQFTGVISTTEELDFESSPEIY-RFIVRASDWGSPYRHESEVNVTIRIG 569
Query: 850 DANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDAD 909
+ N + P+F+ ++ D P+G I +SA D D E + + + L F ++ D
Sbjct: 570 NVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPD 629
Query: 910 SGAITLQAPL--------------------DYEDQVTYTLAI----------TARDNGIP 939
SG + L+ L + D ++ +++ + R+ +
Sbjct: 630 SGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVA 689
Query: 940 QK-ADTTYVEVMVN-------------DVNDNAPQFVASHYTGL-VSEDAPPFTSVLQIS 984
QK A+ ++ N +N P F S + + V ED P ++L+I
Sbjct: 690 QKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIK 749
Query: 985 ATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGV 1044
A D D+ NG+V +T +G + D F I+ +G ++ + +DRE +Y L D G
Sbjct: 750 AYDADSGFNGKVLFTISDG-NTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGN 808
Query: 1045 PPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMY 1104
P + + + V+D NDN+PVF + + V + E+S +G+ + Q+ A D D G N + Y
Sbjct: 809 PQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTY 868
Query: 1105 QIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQA-----TSAPLVSRATVHVRL 1159
++ + F ++ +G + LD E++ Y + ++A + L S T+ V L
Sbjct: 869 SVLTDT--QQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFL 926
Query: 1160 VDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDVSDHLFYSFERGNELQ- 1217
D ND SP + ++Y + P G +I + +DPD+ + N+
Sbjct: 927 DDVNDCSPA-----FIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNG 981
Query: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCV----LRVVIITEEL 1270
+++ SG +RLS++LD + ++ V D V+ V + VV + E L
Sbjct: 982 RFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENL 1038
Score = 165 bits (417), Expect = 8e-40
Identities = 159/611 (26%), Positives = 279/611 (45%), Gaps = 51/611 (8%)
Query: 545 FSEKRYVAQVREDVRPHTVV-----LRVTATDRDKDANGLVHYNIISGNSRGHF-AIDSL 598
F+ Y A V E+ T V + +T D D + Y I+SG+ G F A + +
Sbjct: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWD----IKYRIVSGDEEGFFKAEEVI 98
Query: 599 TGEIQVV---------APLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIP 649
+ + A L+ E + Y L ++ G L T + +IQV+D+ND P
Sbjct: 99 IADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED-LEAWTKV-NIQVLDMNDLRP 156
Query: 650 IFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVS 709
+F T + V++ E+ PL SV + A DAD G N Y F ++ +G +S
Sbjct: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKV--DLFSVHPTSGVIS 214
Query: 710 VSGPLDRESVEHYFFGVEARD-----HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLR 764
+SG L+ + Y + A D +G+ +S++A + V + +N++ P + H+
Sbjct: 215 LSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT-HVP 273
Query: 765 LNEDAAVGTSVVSVTAVDRDANSAI-SYQITGGNTRNRFAISTQG---GVGLVTLALPLD 820
+ + +VV+V +D AN I S I G+ ++F ++ +G + +D
Sbjct: 274 FSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQID 333
Query: 821 YKQERY-FKLVLTASDRALHDHC----YVHINITDANTHRPVFQSAHYSVSVNEDRPMGS 875
++ Y + L L A D+ C V+I +T F+ Y VS++E P G
Sbjct: 334 WESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV 393
Query: 876 TIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARD 935
+ ++ S + + +++ ++ F+I+ SG I PL+ + Y L +T ++
Sbjct: 394 VVAIVKLSPEPIDVEYKLS--PGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKE 451
Query: 936 NGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGR 995
+ KA T + + D ND+ P+F Y V+E P TSVL +SA+D+D NG
Sbjct: 452 GDL--KAQVT---ISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
Query: 996 VQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDRE-AVSVYELTAYAVDRGVP-PLRTPVSI 1053
+ Y+ F I +G++ T LD E + +Y A D G P + V++
Sbjct: 507 ITYSI--ASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNV 564
Query: 1054 QVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPE 1113
+ + +VNDN+P+F + + + VG + ++A+D DE + Y+I+ GN
Sbjct: 565 TIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELG 622
Query: 1114 LFQMDIFSGEL 1124
F ++ SG L
Sbjct: 623 FFYLNPDSGVL 633
Score = 118 bits (296), Expect = 8e-26
Identities = 126/530 (23%), Positives = 236/530 (44%), Gaps = 56/530 (10%)
Query: 756 FTMKEYHLRLNEDAAVGTSVVS-----VTAVDRDANSAISYQITGGNTRNRFA------- 803
FT Y+ + E++A T V S +T +D + I Y+I G+ F
Sbjct: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWD--IKYRIVSGDEEGFFKAEEVIIA 100
Query: 804 ------ISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA--LHDHCYVHINITDANTHR 855
I T+GG + L+ + + + L++ S R L V+I + D N R
Sbjct: 101 DFCFLRIRTKGGNSAI-----LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLR 155
Query: 856 PVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITL 915
P+F YSV++ E P+ +++ ++A+D D+G N Y ++ + F + SG I+L
Sbjct: 156 PLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISL 215
Query: 916 QAPLDYEDQVTYTLAITARDNGIP-----QKADTTYVEVMVNDVNDNAPQFVASHYTGLV 970
L+Y+++ Y L I A D G+ + T + V + +N++AP +
Sbjct: 216 SGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFS 275
Query: 971 SEDAPPFTSVLQISATDRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGI----VRTVRRL 1025
E P + V + D D ANG ++ + G+ D F + + ++ +++
Sbjct: 276 LEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQI 332
Query: 1026 DREAVSV-YELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPV-FPAEEFEVRVKENSIVG 1083
D E+ Y LT A D+G P + + + D P+ F E ++V + E S G
Sbjct: 333 DWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPG 392
Query: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143
VVA I + P+ + Y++ G F+++ SG + L+ ++ Y + V
Sbjct: 393 VVVA-IVKLSPEP---IDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT 448
Query: 1144 ATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGI-IGRIPAYDPDV 1202
L ++ T+ + D ND++P Q L++ YV +++ P G + + A D D
Sbjct: 449 NKEGDLKAQVTISIE--DANDHTPEFQ--QPLYDAYV---NESVPVGTSVLTVSASDKDK 501
Query: 1203 SDHLFYSFERGN-ELQLLVVNQTSGELRLSRKLD-NNRPLVASMLVTVTD 1250
++ + ++ + L V+NQ +G + + +LD + P + +V +D
Sbjct: 502 GENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
Score = 80.9 bits (198), Expect = 2e-14
Identities = 88/344 (25%), Positives = 134/344 (38%), Gaps = 45/344 (13%)
Query: 1726 CDSGPCKNSGFCSERWGS---FSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMA 1782
C PC C S F C CP G G+ T F GN + + S+ +
Sbjct: 3799 CVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLS---FAGNSYIKYRL-SENS 3854
Query: 1783 VSVPWYLGLAFRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVT 1842
+ L L RT + G++M +A P ++ ++ G L + GSG L +
Sbjct: 3855 KEEDFKLALRLRTLQSNGIIMYTRANP--CIILKIVDGKLWFQLDCGSGPGI-LGISGRA 3911
Query: 1843 VSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFS--------LFQDTMAVGSELQ-GLKVK 1893
V+DG WH + LEL + +SLD S L+ T++ S + G V+
Sbjct: 3912 VNDGSWHSVFLEL--------NRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVQ 3963
Query: 1894 QLHVGGLPPGSAEEAPQGLVGCIQGVWLGST----PSGSPALLPPSHRVNAEPGCVV-TN 1948
++ L + G GC+ V L + + + + GCV+ +
Sbjct: 3964 ADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVLYPD 4023
Query: 1949 ACASGPCPPHADCRDLWQ-TFSCTCQPGYYGPGC---VDACLLNPCQNQGSCRHLPGAPH 2004
AC PC C L + CTC + G C + AC NPC+N GSC +
Sbjct: 4024 ACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNT-- 4081
Query: 2005 GYTCDCVGGYFGHHCEHRMD----QQCPRGWWGSPTCGP--CNC 2042
+ C+C G G CE ++ ++C G G CNC
Sbjct: 4082 -FICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNC 4124
Score = 80.1 bits (196), Expect = 3e-14
Identities = 42/129 (32%), Positives = 55/129 (42%), Gaps = 24/129 (18%)
Query: 1377 NVCLREPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETEL 1436
+ C R PC++ C + P G +C C FTG CE+E+
Sbjct: 4023 DACKRSPCQHGGSCTGL---------------------PSGGYQCTCLSQFTGRNCESEI 4061
Query: 1437 DLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNG 1496
C+ NPCRNGG+C + C C+ TG CE D C C NGG+C + G
Sbjct: 4062 TACFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEED--INECEREECENGGSCVNV-FG 4118
Query: 1497 GFRCQCPAG 1505
F C C G
Sbjct: 4119 SFLCNCTPG 4127
Score = 69.3 bits (168), Expect = 6e-11
Identities = 36/84 (42%), Positives = 44/84 (52%), Gaps = 6/84 (7%)
Query: 1432 CETELDLCYSNPCRNGGAC-ARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTC 1490
C D C +PC++GG+C GGY C C +FTG +CE +E C P CRNGG+C
Sbjct: 4018 CVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCE--SEITACFPNPCRNGGSC 4075
Query: 1491 TDAPNGGFRCQCPAGGAFEGPRCE 1514
D F C C AG G CE
Sbjct: 4076 -DPIGNTFICNCKAG--LTGVTCE 4096
Score = 52.8 bits (125), Expect = 6e-06
Identities = 20/52 (38%), Positives = 27/52 (51%)
Query: 1421 CRCPPGFTGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCEL 1472
C C G TG CE +++ C C NGG+C G + C C P + G+ C L
Sbjct: 4084 CNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCGL 4135
Score = 40.0 bits (92), Expect = 0.038
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 1719 CQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKDCQL 1759
C+ ++ C+ C+N G C +GSF C+C G+ G+ C L
Sbjct: 4095 CEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCGL 4135
Score = 35.0 bits (79), Expect = 1.2
Identities = 17/61 (27%), Positives = 22/61 (36%), Gaps = 1/61 (1%)
Query: 1961 CRDLWQTFSCTCQPGYYGPGCVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCE 2020
C ++ CTC G PG D C+ PC C + + C C G G
Sbjct: 3776 CPRFYRNVRCTCNGGLC-PGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSG 3834
Query: 2021 H 2021
H
Sbjct: 3835 H 3835
Score = 32.3 bits (72), Expect = 8.0
Identities = 12/34 (35%), Positives = 16/34 (47%)
Query: 1948 NACASGPCPPHADCRDLWQTFSCTCQPGYYGPGC 1981
N C C C +++ +F C C PGY G C
Sbjct: 4100 NECEREECENGGSCVNVFGSFLCNCTPGYVGQYC 4133
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 431 bits (1109), Expect = e-120
Identities = 328/1010 (32%), Positives = 481/1010 (47%), Gaps = 60/1010 (5%)
Query: 238 ASGSGPELDSAPRTARTAPASGSAPRESRTAPEPAPK---RMRSRGLFRCRFLPQRPGPR 294
A G GP D R R P + ++RT AP+ R + L RP
Sbjct: 1463 ADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANA 1522
Query: 295 PPGLPARPEARK-VTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPD 353
AR AR VT N + P F + + +PE++ G A L VVA+DPD
Sbjct: 1523 SRRRAARVSARVFVTDEN--------DNAPVFASPS-RVRLPEDQPPGPAALHVVARDPD 1573
Query: 354 AGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRL 413
GEA R+ Y LA+ + F + +G + LDRE H L V A DHGSP
Sbjct: 1574 LGEAARVSYRLASGGDGH----FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPR 1629
Query: 414 SATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFV 473
SAT ++ V+VAD ND +P F+Q +Y LREN G +L LRATD D N + Y V
Sbjct: 1630 SATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGV 1689
Query: 474 GPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHI 533
++ +F +DP +G+++T +DRE E L V A D+G P TVRV
Sbjct: 1690 --------SSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRV-- 1739
Query: 534 TVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHF 593
V DEND+AP F +V E P T+ + + A+D D ANG + Y I+ G+ G F
Sbjct: 1740 AVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRILDGDPSGAF 1798
Query: 594 AIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVS 653
+D +GE + PLD E E + LRI A+D G+P LS T L ++ V+D NDH P F
Sbjct: 1799 VLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSA-TLLLTVTVLDANDHAPAFPV 1857
Query: 654 TPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGP 713
+ V V E+ P G ++ +QA D D G N + Y L G F++ ++G + +
Sbjct: 1858 PAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL-GAGTAGAFLLEPSSGELRTAAA 1916
Query: 714 LDRESVEHYFFGVEARDHGSP-PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNED---- 768
LDRE Y F V A D + PLS + SVT+TV DVND+ P F LRL
Sbjct: 1917 LDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSF 1976
Query: 769 AAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERY 826
+ ++ ++ A DRDA N++I Y++ G S G + + + L ++R
Sbjct: 1977 STPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALG-PRDRV 2035
Query: 827 FKLVLTASDRALHDHCYVHINITDANTHR-PVFQSAHYSVSVNEDRPMGSTIVVISASDD 885
+V T R V I R P F A ++ E+ P G+ IV A
Sbjct: 2036 LFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHA 2095
Query: 886 DVGENARITY--LLEDNLPQFRIDADSGAITLQAP--LDYEDQVTYTLAITARDNGIPQK 941
G N ITY L + F I +GAIT+++ LD+E L + A G
Sbjct: 2096 G-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA--- 2151
Query: 942 ADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQ 1001
T + + + D NDNAP+F+ HY + E P +LQ+ A D D + G++ Y+
Sbjct: 2152 FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLA 2211
Query: 1002 NGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVN 1061
+ G F ++PT+G + T LDRE + L A DRG P L ++ VMV D N
Sbjct: 2212 ASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTN 2271
Query: 1062 DNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIP-ELFQMDIF 1120
DN P P + +E+RV E++++GS +AQ+T D D GP +++ ++ + P + F + +
Sbjct: 2272 DNRPTIP-QPWELRVSEDALLGSEIAQVTGNDVDSGP---VLWYVLSPSGPQDPFSVGRY 2327
Query: 1121 SGELTALIDLDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN--FQILFNN 1178
G ++ LD+E Y + + A P RA + V + D NDN+P + +Q++
Sbjct: 2328 GGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLE 2387
Query: 1179 YVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGEL 1228
+ T P I + A D D + S+ + V+ +G L
Sbjct: 2388 H------TPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTL 2431
Score = 405 bits (1040), Expect = e-112
Identities = 313/987 (31%), Positives = 477/987 (48%), Gaps = 63/987 (6%)
Query: 319 ANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
AN H P FP Y VPE+ AGT +L++ A DPDAG G + Y L A + F
Sbjct: 1848 ANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGA----GTAGAFL 1903
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPR-LSATTMVAVTVADRNDHSPVFEQA 436
++P SG +RTAAALDRE + V+A D + LS T V +TV D NDH+P F +
Sbjct: 1904 LEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTS 1963
Query: 437 QYRETL-RENVEEGYPILQL---RATDGDAPPNANLRYRFVG-PPAARAAAAAAFEIDPR 491
R L R P L L RA D DA NA++ YR G PP + EI
Sbjct: 1964 PLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVA 2023
Query: 492 SGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYV 551
++ R DR L + A+D G+ RSAT + + + E + P+F
Sbjct: 2024 RSPVALGPR-DRV------LFIVATDLGRPA--RSATGVIIVGLQGEAERGPRFPRASSE 2074
Query: 552 AQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAP--LD 609
A +RE+ P T ++ A NG + Y+I+SGN +G F+I TG I V + LD
Sbjct: 2075 ATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLD 2133
Query: 610 FEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
FE L ++A+ G + + ++ + D ND+ P F+ + + E+ PL
Sbjct: 2134 FEVSPRLRLVLQAESGGAFAFT----VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGP 2189
Query: 670 VIHIQAVDADHGENARLEYSLTGVAPDTP-FVINSATGWVSVSGPLDRESVEHYFFGVEA 728
++ ++A D D G ++ YSL P F ++ TG ++ + LDRE + A
Sbjct: 2190 LLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMA 2249
Query: 729 RDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA 788
D GSP L SA++TV V+D NDNRP + + LR++EDA +G+ + VT D D+
Sbjct: 2250 TDRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIAQVTGNDVDSGPV 2308
Query: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINI 848
+ Y ++ ++ F++ GG V+L PLD++Q ++L L A D + + +
Sbjct: 2309 LWYVLSPSGPQDPFSVGRYGG--RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLV 2366
Query: 849 TDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDA 908
D N + P F + Y V + E P GS I+ +SA+D D G N I+Y L F +D
Sbjct: 2367 EDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDP 2426
Query: 909 DSGA---ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
++G I L ++ + + ARD+G P +A V V + D ND+AP F SH
Sbjct: 2427 NNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSH 2486
Query: 966 YTGLVSEDAPPFTSVLQISATDRD-AHANGRVQYTFQNGEDGDGDFTIEP---------- 1014
Y V+ED PP +++L + ATD D + ++ V Y+ +G G F +EP
Sbjct: 2487 YRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRV-FQLEPRLAEAGESAG 2545
Query: 1015 ----TSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAE 1070
G + + LD E+++ Y LT A DRG PP + V + V V DVNDN PVF
Sbjct: 2546 PGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRA 2605
Query: 1071 EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDL 1130
+ V V E++ VG+ + + A D D GP+ + + + G+ LF++D SG L L
Sbjct: 2606 SYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHAL 2665
Query: 1131 DYEARQEYVIVVQAT--SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFP 1188
D E + + +VVQA + + A V + + D ND+ P +L + N+ P
Sbjct: 2666 DCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAF-PLNLLSTSVAENQP---P 2721
Query: 1189 SGIIGRIPAYDPDVS--DHLFYS-FERG---NELQLLVVNQTSGELRLSRKLDNNRPLVA 1242
++ + A D D L YS E G + +N ++GELR D
Sbjct: 2722 GTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESF 2781
Query: 1243 SMLVTVTDGLHSVTAQCVLRVVIITEE 1269
+LV D +++A + V++ E+
Sbjct: 2782 RLLVGAADA-GNLSASVTVSVLVTGED 2807
Score = 376 bits (966), Expect = e-103
Identities = 304/986 (30%), Positives = 472/986 (47%), Gaps = 68/986 (6%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P+F Y+ +P AGT VL+V AQ PD G + Y LAA S F ++PQS
Sbjct: 998 PRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSP---FGLEPQS 1051
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRL---SATTMVAVTVADRNDHSPVFEQAQYR 439
G + AALDRE+ E + L+V A L + T V V++ ++N+HSP +
Sbjct: 1052 GWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTF 1111
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
+ EN G + ++ ATD D+ PN L Y + + AF I P++G ++T
Sbjct: 1112 LAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL----QQLSEDSKAFRIHPQTGEVTTLQ 1167
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA------Q 553
+DRE SY+L+V+ D G P RS T VH+ VLD NDN+P F + A Q
Sbjct: 1168 TLDREQQSSYQLLVQVQDGGSPP--RSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQ 1225
Query: 554 VREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAE 613
V + V P T+V + A D D+ NG + Y + +G F++ +GE+ APL
Sbjct: 1226 VPDRVPPGTLVTTLQAKDPDEGENGTILYTL-TGPGSELFSLHPHSGELLTAAPLIRAER 1284
Query: 614 REYALRIRAQDAGRPPLSNNTGLASIQVV----------DINDHIPIF-VSTPFQVSVLE 662
Y L + A D G PP S + L +QV+ D+ + P V V+ E
Sbjct: 1285 PHYVLTLSAHDQGSPPRSASLQLL-VQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAE 1343
Query: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVA-PDTPFVINSATGWVSVSGPLDRESVEH 721
G S++ A G A L Y+L G A P+ F +++A+G + ++ PLD E+
Sbjct: 1344 GLRPG-SLLGSVAAPEPAGVGA-LTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPP 1401
Query: 722 YFFGVEARDHGSPPLSASA-SVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTA 780
+ + R G A V V V D N++ P F L L E+ G ++ + A
Sbjct: 1402 WR-ALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRA 1460
Query: 781 VDRDA---NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA 837
D D NS + Y++ A+ G ++ LD + L++ A+DR
Sbjct: 1461 SDADGPGPNSDVRYRLLRQEPPVP-ALRLDARTGALSAPRGLDRETTPALLLLVEATDRP 1519
Query: 838 LHD------HCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENA 891
+ + +TD N + PVF S V + ED+P G + + A D D+GE A
Sbjct: 1520 ANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAA 1578
Query: 892 RITYLLEDNLP-QFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVM 950
R++Y L FR+ + +GA+++ PLD E + + L + A D+G P ++ T + V
Sbjct: 1579 RVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVS 1638
Query: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDF 1010
V DVND AP F Y+ L+ E+ PP TS+L + ATD D ANG+V Y + E F
Sbjct: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES----F 1694
Query: 1011 TIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAE 1070
+++P +G++ T+R LDRE LT YA DRG PP T V+++V V+D ND+AP F +
Sbjct: 1695 SLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSA 1754
Query: 1071 EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDL 1130
+ V E + + A DPD G N + Y+I++G+ F +D+ SGE + L
Sbjct: 1755 HLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPL 1813
Query: 1131 DYEARQEYVIVVQATSA---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTF 1187
D E + + ++A L + + V ++D ND++P Y +
Sbjct: 1814 DREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP-----VPAYSVEVPEDV 1868
Query: 1188 PSG-IIGRIPAYDPDV--SDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASM 1244
P+G ++ ++ A+DPD + H+ Y G L+ +SGELR + LD + +
Sbjct: 1869 PAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLL-EPSSGELRTAAALDREQCPSYTF 1927
Query: 1245 LVTVTDGLHSVTAQCVLRVVIITEEL 1270
V+ DG + + V I ++
Sbjct: 1928 SVSAVDGAAAGPLSTTVSVTITVRDV 1953
Score = 360 bits (923), Expect = 2e-98
Identities = 309/936 (33%), Positives = 441/936 (47%), Gaps = 65/936 (6%)
Query: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
+ E + AGT + + A P AG A L+Y ++A S +ID SG++RTA LDR
Sbjct: 51 IDEEQPAGTLIGDISAGLP-AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDR 109
Query: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEG--YP 451
E +R+ D AT V V VAD NDH+P F QA+ + E+ G YP
Sbjct: 110 EQRDRYRFTAVTPD------GATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYP 163
Query: 452 ILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST-------SGRVDRE 504
+ R D DA Y G A F ++ R G T +G +DRE
Sbjct: 164 LEPAR--DADAGRLGTQGYALSGD-----GAGETFRLETRPGPDGTPVPELVVTGELDRE 216
Query: 505 HMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVV 564
+ Y L +EA D G PR A + +T+LD ND+AP F++ RY A V E + P + V
Sbjct: 217 NRSHYMLQLEAYDGGSP--PRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPV 274
Query: 565 LRVTATDRDKDANGLVHYNIISGNSRGH--FAIDSLTGEIQVVAPLDFEAEREYALRIRA 622
L+V A+D D NG V Y I S G F+ID+ TG +Q+ PLDFE R + L ++A
Sbjct: 275 LQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQA 334
Query: 623 QDAGRPPLSNNTGLASIQVVDINDHIP----IFVSTPFQVSVLENAPLGHSVIHIQAVDA 678
+D G P + ++ V D ND+ P IF+S V E AP G V I D
Sbjct: 335 RDGGAHP-ELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDP 393
Query: 679 DHGENARLEYSLTGVAPDTPFVI---NSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP 735
D G+ A + SL G + F + +S V V+ LDRE + Y V A D GSPP
Sbjct: 394 DDGDFAHVNVSLEG--GEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPP 451
Query: 736 LSASASVTVTVLDVNDNRPEFTMKEYHLR-LNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
L A A+ + V DVNDN P F + Y L E A G+ VV VTA D D N ++Y
Sbjct: 452 LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYS 511
Query: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINIT 849
+ G + F+I G+ +T A LDY+ E +L++ A+D L V + +
Sbjct: 512 LAPGAHTHWFSIDPTSGI--ITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQ 569
Query: 850 DANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL-----PQF 904
D N + P FQ Y+ S+ E G+ + ++A+D D G ++Y L L P F
Sbjct: 570 DVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPF 629
Query: 905 RIDADSGAITLQAPLDYED-QVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVA 963
RIDA SG + LD + ++ +TA D G YV+V ++D NDN PQF
Sbjct: 630 RIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYP 687
Query: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR 1023
Y +S +PP T+VL++ A D D ++GR+ Y G + FT++ SG++
Sbjct: 688 REYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAG-NSPPLFTLDEQSGLLTVAW 746
Query: 1024 RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVG 1083
L R A SV +L A D G + + + P+F ++ V E+ G
Sbjct: 747 PLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPG 806
Query: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV-IVV 1142
+ V + A +P G A + + G+ LF +D SG L L LD E + + V
Sbjct: 807 TSVGIVQAHNP-PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEV 865
Query: 1143 QATSA--PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDP 1200
+A S P + A V V L D NDNSP + + V +T P I + A DP
Sbjct: 866 RAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPE----DTVLLPPNTAPGTPIYTLRALDP 921
Query: 1201 D--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKL 1234
D V+ + ++ G V+ T+G +RL R L
Sbjct: 922 DSGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRPL 956
Score = 350 bits (899), Expect = 1e-95
Identities = 295/935 (31%), Positives = 437/935 (46%), Gaps = 54/935 (5%)
Query: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
+PE G+ V+RV A+DPD G G++ YSLA ++ FSIDP SG+I TAA+LD
Sbjct: 482 LPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTH---WFSIDPTSGIITTAASLDY 538
Query: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL 453
E + L V A D G P L+++ V+V + D ND+ P F++ Y +L E + G L
Sbjct: 539 ELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFL 598
Query: 454 QLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREH-MESYELV 512
Q+ ATD D+ P L Y ++ + F ID SG + T+ +DR+ S++
Sbjct: 599 QVTATDADSGPFGLLSYSLGA--GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFT 656
Query: 513 VEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDR 572
V A D G G +S V V + + DENDN PQF + Y A + P T VLR+ A D
Sbjct: 657 VTAVDGG---GLKSM-VYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDP 712
Query: 573 DKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSN 632
D+ ++G + Y+I++GNS F +D +G + V PL A L I A+D G +
Sbjct: 713 DQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQ-AE 771
Query: 633 NTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTG 692
+ I +V PIF + SV E+ G SV +QA + G A + SL+G
Sbjct: 772 PSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSG 830
Query: 693 VAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDN 752
P F +++ +G + PLDRE + G PP A A V V + DVNDN
Sbjct: 831 GDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDN 890
Query: 753 RPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGV 810
P F E + L + A GT + ++ A+D D+ NS +++ + G A +
Sbjct: 891 SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGG---AFTVDPTT 947
Query: 811 GLVTLALPLDYKQERYFKLVLTASDRALH---DHCYVHINITDANTH--RPVFQSAHYSV 865
G V L PL +L L A D H + + + D T P F S Y V
Sbjct: 948 GHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV 1007
Query: 866 SVNEDRPMGSTIVVISASDDDVGENARITYLL--EDNLPQFRIDADSGAITLQAPLDYED 923
+ G+ ++ + A D G ITY L E F ++ SG + ++A LD E
Sbjct: 1008 DLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREA 1064
Query: 924 QVTYTLAITARDNG---IPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSV 980
Q Y L + A + Q+ T V V + + N+++P+ V+E+ PP TSV
Sbjct: 1065 QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSV 1124
Query: 981 LQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV 1040
++ ATDRD+ NGR+ Y+ Q + F I P +G V T++ LDRE S Y+L
Sbjct: 1125 GRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQ 1184
Query: 1041 DRGVPPLRTPVSIQVMVQDVNDNAPVF------PAEEFEVRVKENSIVGSVVAQITAVDP 1094
D G PP T ++ V V D+NDN+P F ++V + G++V + A DP
Sbjct: 1185 DGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDP 1244
Query: 1095 DEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQA---------T 1145
DEG N I+Y + G ELF + SGEL L R YV+ + A
Sbjct: 1245 DEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSA 1303
Query: 1146 SAPLVSRATVHVRLV----DQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201
S L+ + RL D + P +L V+ P ++G + A +P
Sbjct: 1304 SLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVL---TVTAAEGLRPGSLLGSVAAPEPA 1360
Query: 1202 VSDHLFYSFERGNELQ-LLVVNQTSGELRLSRKLD 1235
L Y+ G + + ++ SG L L+R LD
Sbjct: 1361 GVGALTYTLVGGADPEGTFALDAASGRLYLARPLD 1395
Score = 349 bits (896), Expect = 2e-95
Identities = 270/860 (31%), Positives = 395/860 (45%), Gaps = 39/860 (4%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P FPQ VPE+ A GT A+D DAG G Y AL + E F ++ +
Sbjct: 141 PAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGY---ALSGDGAGETFRLETRP 197
Query: 383 GLIRT-------AAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
G T LDRE+ + L++ A D GSP A ++ VT+ D NDH+P F Q
Sbjct: 198 GPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQ 257
Query: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
++Y + E++ G P+LQ+ A+D DA N + Y ++ F ID +GL+
Sbjct: 258 SRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEI---NRRQSEGDGPFSIDAHTGLL 314
Query: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQ----FSEKRYV 551
+D E +ELVV+A D G P SA V VH V D NDN P F
Sbjct: 315 QLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVH--VRDANDNQPSMTVIFLSADGS 372
Query: 552 AQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAI---DSLTGEIQVVAPL 608
QV E P +V R++ + D D H N+ GHFA+ DS+ + V L
Sbjct: 373 PQVSEAAPPGQLVARISVS--DPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRL 430
Query: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPL-G 667
D E Y LR+ A D+G PPL + V D+ND+ P F ++ L L G
Sbjct: 431 DREERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPG 489
Query: 668 HSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVE 727
V+ + A D D G N ++ YSL A F I+ +G ++ + LD E V
Sbjct: 490 SFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVV 549
Query: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
A D G PPL++SA+V+V + DVNDN P+F Y+ L E GT + VTA D D+
Sbjct: 550 ATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGP 609
Query: 787 -SAISYQI---TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHC 842
+SY + G + F I G T L D + V L
Sbjct: 610 FGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMV 669
Query: 843 YVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY--LLEDN 900
YV + ++D N + P F Y+ S++ P G+ ++ + A D D G + R++Y L ++
Sbjct: 670 YVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNS 729
Query: 901 LPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ 960
P F +D SG +T+ PL L I A D G Q + V++ + P
Sbjct: 730 PPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 789
Query: 961 FVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVR 1020
F Y V ED P TSV + A + V + G D G F+++ SG+++
Sbjct: 790 FEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRL-APVTLSLSGG-DPRGLFSLDAVSGLLQ 847
Query: 1021 TVRRLDREAVS-VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
T+R LDRE + V EL A GVPP ++V++ DVNDN+P FPA E V + N
Sbjct: 848 TLRPLDRELLGPVLELEVRA-GSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPN 906
Query: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV 1139
+ G+ + + A+DPD G N+ + + ++ G F +D +G + + L +
Sbjct: 907 TAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHE 965
Query: 1140 IVVQATSAPLVSRATVHVRL 1159
+ ++A R T H RL
Sbjct: 966 LELEARDGGSPPR-TSHFRL 984
Score = 326 bits (836), Expect = 2e-88
Identities = 272/915 (29%), Positives = 418/915 (45%), Gaps = 60/915 (6%)
Query: 228 TAPRRNCLP--GASGSGPELDSAPRTARTAPASGSAPRESRTAPEPAPKRMRSR--GLFR 283
T+P R LP G S S P L A A A +A R A P P G R
Sbjct: 1962 TSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIR 2021
Query: 284 CRFLPQRPGPRPPGL------PARPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPEN 337
P GPR L RP AR T + A R P+FP+ + + + EN
Sbjct: 2022 VARSPVALGPRDRVLFIVATDLGRP-ARSATGVIIVGLQGEAERGPRFPRASSEATIREN 2080
Query: 338 EAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLI--RTAAALDRES 395
GT ++ A G G + YS+ ++ FSI P +G I R+A LD E
Sbjct: 2081 APPGTPIVSPRAVHA-GGTNGPITYSI---LSGNEKGTFSIQPSTGAITVRSAEGLDFEV 2136
Query: 396 MERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQL 455
R L + A+ G+ A T++ +T+ D ND++P F + Y L E+ P+LQ+
Sbjct: 2137 SPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQV 2193
Query: 456 RATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEA 515
A D D + Y AA A F +DP +G I+T+ +DRE LV+ A
Sbjct: 2194 EADDLDQGSGGQISYSL----AASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMA 2249
Query: 516 SDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKD 575
+D+G SAT+ V V+D NDN P + + +V ED + + +VT D D
Sbjct: 2250 TDRGSPALVGSATLTV--MVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGND--VD 2304
Query: 576 ANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTG 635
+ ++ Y + + F++ G + + PLDFE Y L++ A D +N T
Sbjct: 2305 SGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTV 2364
Query: 636 LASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAP 695
L V D+ND+ P F + +QV +LE+ P G +++ + A D D G N + Y L A
Sbjct: 2365 L----VEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPAD 2420
Query: 696 DTPFVINSATGWVSVSG-PLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRP 754
N+ T + V L + +EARDHG+P +A A+V V + D ND+ P
Sbjct: 2421 GFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAP 2480
Query: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRD---ANSAISYQITGGNTRNRFAISTQ---- 807
FT+ Y + + ED G++++++ A D D +++A+ Y I GN F + +
Sbjct: 2481 SFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEA 2540
Query: 808 --------GGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYV---HINITDANTHRP 856
+G + L PLD++ + L + A+DR V + + D N + P
Sbjct: 2541 GESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPP 2600
Query: 857 VFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGAIT 914
VF A Y V+V ED P+G+ ++ + ASD D G + + + + P F +D SG +
Sbjct: 2601 VFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLR 2660
Query: 915 LQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDA 974
L LD E Q + L + A D A V + V DVND+ P F + + V+E+
Sbjct: 2661 LAHALDCETQARHQLVVQAADPAGAHFA-LAPVTIEVQDVNDHGPAFPLNLLSTSVAENQ 2719
Query: 975 PPFTSVLQISATDRDAHANGRVQYTFQN---GEDGDGDFTIEPTSGIVRTVRRLDREAVS 1031
PP T V + A D DA A GR++Y+ G +G F + ++G +R D E
Sbjct: 2720 PPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTE 2779
Query: 1032 VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITA 1091
+ L A D G L V++ V+V ++ PVF A F +V E + G + + A
Sbjct: 2780 SFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQA 2837
Query: 1092 VDPDEGPNAHIMYQI 1106
D D G + ++Y +
Sbjct: 2838 TDEDGGADGLVLYSL 2852
Score = 301 bits (770), Expect = 9e-81
Identities = 287/1016 (28%), Positives = 446/1016 (43%), Gaps = 73/1016 (7%)
Query: 297 GLPARPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGE 356
GLP + V+ A + + PQF + Y +PE GT L+V A D D+G
Sbjct: 554 GLPPLASSATVSVA----LQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGP 609
Query: 357 AGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHY-LRVTAQDHGSPRLSA 415
G L YSL A + S F ID SG + T LDR+ + VTA D G L +
Sbjct: 610 FGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG--LKS 667
Query: 416 TTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGP 475
V V ++D ND+ P F +Y ++ G +L+LRA D D + L Y +
Sbjct: 668 MVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILA- 726
Query: 476 PAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITV 535
+ F +D +SGL++ + + R +L + A D G SA RV I++
Sbjct: 727 ----GNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSA--RVDISI 780
Query: 536 LDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAI 595
+ P F + +YV V EDV P T V + V ++ G+ RG F++
Sbjct: 781 VPGTPTPPIFEQLQYVFSVPEDVAPGTSV-GIVQAHNPPGRLAPVTLSLSGGDPRGLFSL 839
Query: 596 DSLTGEIQVVAPLDFE-AEREYALRIRAQDAGRPPLSNNTGLASIQVV--DINDHIPIFV 652
D+++G +Q + PLD E L +RA +G PP +A ++V+ D+ND+ P F
Sbjct: 840 DAVSGLLQTLRPLDRELLGPVLELEVRA-GSGVPPA---FAVARVRVLLDDVNDNSPAFP 895
Query: 653 STPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSG 712
+ V + N G + ++A+D D G N+R+ ++L F ++ TG V +
Sbjct: 896 APEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLL-AGGGGAFTVDPTTGHVRLMR 954
Query: 713 PLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDN--RPEFTMKEYHLRLNEDAA 770
PL + +EARD GSPP ++ + V V DV P F Y + L
Sbjct: 955 PLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTT 1014
Query: 771 VGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLV 830
GT V+ V A D I+Y + + F + Q G V AL + ++ K++
Sbjct: 1015 AGTQVLQVQAQAPD-GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVM 1073
Query: 831 LTASDRA----LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDD 886
+ +A V ++I + N H P ++V E++P G+++ + A+D D
Sbjct: 1074 AVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRD 1133
Query: 887 VGENARITYLLE---DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKAD 943
G N R+TY L+ ++ FRI +G +T LD E Q +Y L + +D G P ++
Sbjct: 1134 SGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
Query: 944 TTYVEVMVNDVNDNAPQFV-ASHYTG-----LVSEDAPPFTSVLQISATDRDAHANGRVQ 997
T V V V D+NDN+P F+ AS G V + PP T V + A D D NG +
Sbjct: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTIL 1253
Query: 998 YTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMV 1057
YT G F++ P SG + T L R Y LT A D+G PP S+Q++V
Sbjct: 1254 YTLTG--PGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPP--RSASLQLLV 1309
Query: 1058 Q------------DVNDNAPVFPAE-EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMY 1104
Q D+ + P P V E GS++ + A +P G A + Y
Sbjct: 1310 QVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP-AGVGA-LTY 1367
Query: 1105 QIVEGNIPE-LFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSRA---TVHVRLV 1160
+V G PE F +D SG L LD+EA + + P + A V V++
Sbjct: 1368 TLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQ 1427
Query: 1161 DQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD----VSDHLFYSFERGNEL 1216
D+N+++P + ++ + P + A D D SD + + +
Sbjct: 1428 DENEHAPAFARDPLA----LALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPV 1483
Query: 1217 QLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRV---VIITEE 1269
L ++ +G L R LD +LV TD + + + RV V +T+E
Sbjct: 1484 PALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDE 1539
Score = 291 bits (745), Expect = 7e-78
Identities = 223/687 (32%), Positives = 319/687 (46%), Gaps = 43/687 (6%)
Query: 594 AIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVS 653
AID +G ++ LD E Y D T +++V DINDH P F
Sbjct: 93 AIDEHSGVVRTARVLDREQRDRYRFTAVTPDGA-------TVEVTVRVADINDHAPAFPQ 145
Query: 654 TPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATG------- 706
+ V E+ G A DAD G Y+L+G F + + G
Sbjct: 146 ARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVP 205
Query: 707 WVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLN 766
+ V+G LDRE+ HY +EA D GSPP A A + VT+LD+ND+ P F YH ++
Sbjct: 206 ELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVS 265
Query: 767 EDAAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQE 824
E A G+ V+ V A D DA N A++Y+I + S GL+ L PLD++Q
Sbjct: 266 ESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQR 325
Query: 825 RYFKLVLTASDRALHDH---CYVHINITDANTHRP----VFQSAHYSVSVNEDRPMGSTI 877
R +LV+ A D H +V +++ DAN ++P +F SA S V+E P G +
Sbjct: 326 RVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLV 385
Query: 878 VVISASDDDVGENARITYLLEDNLPQFRIDADSGAITL---QAPLDYEDQVTYTLAITAR 934
IS SD D G+ A + LE F + I L LD E++ Y L +TA
Sbjct: 386 ARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTAT 445
Query: 935 DNGIPQ-KADTTYVEVMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHA 992
D+G P +A+ +V + V DVNDNAP F Y + E A P + V++++A D D
Sbjct: 446 DSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGT 504
Query: 993 NGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVS 1052
NG+V Y+ G F+I+PTSGI+ T LD E +L A D G+PPL + +
Sbjct: 505 NGQVTYSLAPGAHTHW-FSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSAT 563
Query: 1053 IQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEG--- 1109
+ V +QDVNDN P F + + E + G+ Q+TA D D GP + Y + G
Sbjct: 564 VSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGS 623
Query: 1110 NIPELFQMDIFSGEL--TALIDLDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSP 1167
+ F++D SG++ T +D D V L S V V L D+NDN P
Sbjct: 624 SGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPP 683
Query: 1168 VLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDVSDH--LFYSFERGNELQLLVVNQT 1224
Q Y ++ S P G + R+ A+DPD H L Y GN L +++
Sbjct: 684 -----QFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQ 738
Query: 1225 SGELRLSRKLDNNRPLVASMLVTVTDG 1251
SG L ++ L V + + DG
Sbjct: 739 SGLLTVAWPLARRANSVVQLEIGAEDG 765
Score = 248 bits (632), Expect = 9e-65
Identities = 183/620 (29%), Positives = 307/620 (49%), Gaps = 43/620 (6%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ P PQ ++ V E+ G+ + +V D D+G L Y L+ S + FS+
Sbjct: 2272 DNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPV--LWYVLSP---SGPQDPFSVG 2325
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
G + LD E +R+ L++ A H P + V V D ND++P F Q+ Y+
Sbjct: 2326 RYGGRVSLTGPLDFEQCDRYQLQLLA--HDGPHEGRANLT-VLVEDVNDNAPAFSQSLYQ 2382
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTS- 498
L E+ G IL + ATD D+ N ++ Y P A F +DP +G + T
Sbjct: 2383 VMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP-------ADGFSVDPNNGTLFTIV 2435
Query: 499 GRVDREHMES--YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE 556
G V H S ++V+EA D G PG R+A VH+ + D+ND+AP F+ Y V E
Sbjct: 2436 GTVALGHDGSGAVDVVLEARDHGA-PG-RAARATVHVQLQDQNDHAPSFTLSHYRVAVTE 2493
Query: 557 DVRPHTVVLRVTATDRDKD-ANGLVHYNIISGNSRGHFAIDSLTGE-------------- 601
D+ P + +L + ATD D ++ V Y+IISGN F ++ E
Sbjct: 2494 DLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGC 2553
Query: 602 IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVL 661
+ ++ PLDFE+ +Y L + A D G+PP S+ + ++ V+D+ND+ P+F ++V+V
Sbjct: 2554 LVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPV-TVTVLDVNDNPPVFTRASYRVTVP 2612
Query: 662 ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEH 721
E+ P+G ++H++A DAD G + + ++++ P F ++ ++G + ++ LD E+
Sbjct: 2613 EDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQAR 2672
Query: 722 YFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781
+ V+A D A A VT+ V DVND+ P F + + E+ GT V ++ A+
Sbjct: 2673 HQLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAI 2731
Query: 782 DRDANS--AISYQI--TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA 837
D DA + + Y + G R A + G + +P DY+ F+L++ A+D
Sbjct: 2732 DGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAG 2791
Query: 838 -LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYL 896
L V + +T + + PVF + + V E G ++ + A+D+D G + + Y
Sbjct: 2792 NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYS 2851
Query: 897 LEDNLPQFRIDADSGAITLQ 916
L + P F I+ +GA+ L+
Sbjct: 2852 LATSSPYFGINQTTGALYLR 2871
Score = 167 bits (424), Expect = 1e-40
Identities = 140/459 (30%), Positives = 209/459 (45%), Gaps = 53/459 (11%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLV-YSLAALMNSRSLELFSIDPQ 381
P F +Y+ V E+ G+ +L + A D D + V YS+ + R +F ++P+
Sbjct: 2480 PSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR---VFQLEPR 2536
Query: 382 S--------------GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
G + LD ES+ ++ L V A D G P S+ V VTV D N
Sbjct: 2537 LAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVN 2596
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D+ PVF +A YR T+ E+ G +L + A+D D P+ +R+ + + FE
Sbjct: 2597 DNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT-----VSSGDPSGLFE 2651
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE 547
+D SG + + +D E ++LVV+A+D G A V I V D ND+ P F
Sbjct: 2652 LDESSGTLRLAHALDCETQARHQLVVQAADPA---GAHFALAPVTIEVQDVNDHGPAFPL 2708
Query: 548 KRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGN----SRGHFAIDSLTGEIQ 603
V E+ P T+V + A D D A G + Y+++ R FA++S TGE++
Sbjct: 2709 NLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELR 2768
Query: 604 VVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLEN 663
P D+E + L + A DAG S S+ V +++ P+F++ F V E
Sbjct: 2769 ARVPFDYEHTESFRLLVGAADAGNLSASVTV---SVLVTGEDEYDPVFLAPAFHFQVPEG 2825
Query: 664 APLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSV------------- 710
A GHS+ H+QA D D G + + YSL +P F IN TG + +
Sbjct: 2826 ARRGHSLGHVQATDEDGGADGLVLYSLATSSP--YFGINQTTGALYLRVDSRAPGSGTAT 2883
Query: 711 ---SGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTV 746
G RE+ V AR G P S SA+V VTV
Sbjct: 2884 SGGGGRTRREAPRELRLEVIAR--GPLPGSRSATVPVTV 2920
Score = 81.6 bits (200), Expect = 1e-14
Identities = 68/221 (30%), Positives = 97/221 (43%), Gaps = 10/221 (4%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLA-ALMNSRSLELFSIDPQ 381
P FP T V EN+ GT V + A D DAG GRL YSL A E F+++
Sbjct: 2704 PAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSS 2763
Query: 382 SGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
+G +R D E E L V A D G+ LSA+ V+V V +++ PVF +
Sbjct: 2764 TGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQ 2821
Query: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAA----RAAAAAAFEID---PRSGL 494
+ E G+ + ++ATD D + + Y + A +D P SG
Sbjct: 2822 VPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGT 2881
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITV 535
++ G EL +E +G PG RSATV V + +
Sbjct: 2882 ATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDI 2922
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 395 bits (1015), Expect = e-109
Identities = 315/982 (32%), Positives = 483/982 (49%), Gaps = 58/982 (5%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ P F Q Y + EN GT+VL V+A D DAG G + Y S + FS+D
Sbjct: 455 DNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF-----SDDPDRFSLD 509
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
+GLI A LD E ++R L + A+D G T V + V D ND+ P F++ Y
Sbjct: 510 KDTGLIMLIARLDYELIQRFTLTIIARDGGGEE--TTGRVRINVLDVNDNVPTFQKDAYV 567
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID--PRSGLIST 497
LREN +++LRATD D+PPN + Y V + +A + F+I G+IS
Sbjct: 568 GALRENEPSVTQLVRLRATDEDSPPNNQITYSIV----SASAFGSYFDISLYEGYGVISV 623
Query: 498 SGRVDREHMES--YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVR 555
S +D E + + L V A D G P ++TV V I V DENDN P FS+ Y V
Sbjct: 624 SRPLDYEQISNGLIYLTVMAMDAGNP--PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVV 681
Query: 556 EDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE 615
E++ VL + ATD D+ I S F I++ +GEI + LD E + E
Sbjct: 682 ENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSE 741
Query: 616 YALRIRAQDAGRPPLSNNTGLASIQV--VDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673
Y L +RA D G + TG+A++ + +DIND+ P + P+ ++++E P V +
Sbjct: 742 YILIVRAVDGG-VGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTV 800
Query: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWV-SVSGPLDRESVEHY------FFGV 726
AVD D GEN L YS+ P+ + +NS TG + + LDRE+ + + V
Sbjct: 801 VAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVV 858
Query: 727 EARDHGSPPLSASASVTVTV--LDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD 784
D G PPL A++S TV V LD+NDN P F + + E G S+ V A+D D
Sbjct: 859 SVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLD 918
Query: 785 --ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRAL---H 839
N +SY++ G R F I++ GV V LD ++ ++L + ASD
Sbjct: 919 EGLNGLVSYRMPVGMPRMDFLINSSSGV--VVTTTELDRERIAEYQLRVVASDAGTPTKS 976
Query: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
+ I++ D N P F A Y+VSV+ED P +V ++ +D+DVG NA ++Y +
Sbjct: 977 STSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
Query: 900 NL--PQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQK--ADTTYVEVMVNDVN 955
+F + + LD E Y L + A DNG K T V V V DVN
Sbjct: 1037 GNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVN 1096
Query: 956 DNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPT 1015
DN P F+ S Y V ED P S+LQ+ ATD D GRV Y +G G+ +F I +
Sbjct: 1097 DNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGN-NFRIHVS 1155
Query: 1016 SG-IVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF-E 1073
+G ++R R LDRE S + L A + + P+R+ V + V V+D+ND APVF +++
Sbjct: 1156 NGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSR 1215
Query: 1074 VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYE 1133
+ ++E + +G+ V + A D D G + Y+I+ G F++D +G + + LDYE
Sbjct: 1216 LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYE 1274
Query: 1134 ARQEYVIVVQAT-SAPLVSR--ATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG 1190
+ Y++ V AT AP ++ +V++ L+++ D + +N +Y + + G
Sbjct: 1275 TKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN-----ASYEAAILENLALG 1329
Query: 1191 I-IGRIPAYDPDVSDHLFYSFERGNELQ---LLVVNQTSGELRLSRKLDNNRPLVASMLV 1246
I R+ AY D + + Y F Q L ++ +G + + +D + ++ V
Sbjct: 1330 TEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV 1389
Query: 1247 TVTDGLHSVTAQCVLRVVIITE 1268
DG V + + + ++ E
Sbjct: 1390 VADDGGPKVDSTVKVYITVLDE 1411
Score = 385 bits (990), Expect = e-106
Identities = 290/944 (30%), Positives = 458/944 (48%), Gaps = 47/944 (4%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F + Y + ENE + T ++R+ A D D+ ++ YS+ + S S+
Sbjct: 559 PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY 618
Query: 383 GLIRTAAALDRESMERH--YLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRE 440
G+I + LD E + YL V A D G+P L++T V + V D ND+ P F + Y
Sbjct: 619 GVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV 678
Query: 441 TLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAA--RAAAAAAFEIDPRSGLISTS 498
++ EN+ G +L L ATD D R R G + + F I+ RSG I+T+
Sbjct: 679 SVVENIMAGATVLFLNATDLD-------RSREYGQESIIYSLEGSTQFRINARSGEITTT 731
Query: 499 GRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDV 558
+DRE Y L+V A D G ++ V+IT+LD NDN P + + Y + E
Sbjct: 732 SLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
Query: 559 RPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVV-APLD------FE 611
P + V V A D D NG + Y+I N ++++S TG+I+ A LD E
Sbjct: 792 PPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHE 849
Query: 612 AEREYALRIRAQDAGRPPL-SNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
AE + + D GRPPL + ++ + ++D+ND+ P F + PF VLE P G S+
Sbjct: 850 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSI 909
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
+ A+D D G N + Y + P F+INS++G V + LDRE + Y V A D
Sbjct: 910 YQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD 969
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSA 788
G+P S+++++T+ VLDVND P F Y++ ++ED VV + D D N+
Sbjct: 970 AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029
Query: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD-----RALHDHCY 843
+SY ITGGN +F++ + V V + LD + + L+L A D +
Sbjct: 1030 LSYFITGGNVDGKFSVGYRDAV--VRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTAT 1087
Query: 844 VHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY--LLEDNL 901
V + + D N +RP+F + Y SV ED P G +I+ + A+D D GE R+ Y L ++
Sbjct: 1088 VFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHG 1147
Query: 902 PQFRIDADSGAITL-QAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ 960
FRI +G + PLD E ++ L + A ++ + + V V V D+ND AP
Sbjct: 1148 NNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPV 1207
Query: 961 FVASHYTGL-VSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIV 1019
F Y+ L + E A TSV+ + ATDRD+ G V Y +G +G F I+ ++G++
Sbjct: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG--AEGKFEIDESTGLI 1265
Query: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
TV LD E + Y + A D+ P + S+ + + + D A F +E + EN
Sbjct: 1266 ITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILEN 1325
Query: 1080 SIVGSVVAQITAVDPDE-GPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEY 1138
+G+ + ++ A D + LF++D +G +T +D E Y
Sbjct: 1326 LALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFY 1385
Query: 1139 VIVVQA-TSAPLV-SRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIP 1196
+ V A P V S V++ ++D+NDNSP F ++ VS D + +
Sbjct: 1386 TLTVVADDGGPKVDSTVKVYITVLDENDNSP---RFDFTSDSAVSIPEDCPVGQRVATVK 1442
Query: 1197 AYDPDVSDH--LFYSFERGN---ELQLLVVNQTSGELRLSRKLD 1235
A+DPD + + +S GN +++ N + GE+ ++R LD
Sbjct: 1443 AWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLD 1486
Score = 380 bits (977), Expect = e-105
Identities = 295/959 (30%), Positives = 462/959 (48%), Gaps = 70/959 (7%)
Query: 328 YNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRT 387
+ Y V EN GTAV++V A D D G L Y + + F +D SG I T
Sbjct: 1531 FGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA---FRMDRISGEIAT 1587
Query: 388 AAAL-DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENV 446
A DRE ++L T +D G+P LSATT V VT+ D ND++P+F+Q Y L E
Sbjct: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGP 1647
Query: 447 EE-GYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREH 505
+ ++ ++A D D PN + Y V F ID G+I+ + +D E
Sbjct: 1648 DTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNT-----FRIDRHMGVITAAKELDYEI 1702
Query: 506 MES-YELVVEASDQGQEPGPR-SATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTV 563
Y L+V A+DQ R ++T V + V D NDN P F + +P
Sbjct: 1703 SHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1762
Query: 564 VLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE----YALR 619
V A DRD NG V Y+I+ G+ G F I + G ++V D E +RE Y L
Sbjct: 1763 VWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRK--DVELDRETIAFYNLT 1820
Query: 620 IRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
I A+D G PPLS+ T L I+V+DIND+ P+ ++ P +++ EN+P+ V H+ A DAD
Sbjct: 1821 ICARDRGMPPLSS-TMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
Query: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSAS 739
G NARL +++T + F IN+ TG V+V+ PLDRE + Y + +D+ P A
Sbjct: 1880 SGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIAR 1939
Query: 740 ASVTVTVL---DVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTA------VDRDANSAIS 790
+ ++ D NDN P FT Y + E++ GT + + D+D + ++
Sbjct: 1940 RDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVT 1999
Query: 791 YQITGGNTRNRFAISTQGGVGLVTLALPLDYK--QERYFKLVLTASD-RALHDHCYVHIN 847
YQ+ G + F I++ GV V + +D + +L+L A D L+ ++ I
Sbjct: 2000 YQLLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLIT 2058
Query: 848 ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL-PQFRI 906
I D N +RP F A +V + E+ P G +++ ++A+D+D G N + Y +E +F I
Sbjct: 2059 ILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLI 2118
Query: 907 DADSGAITL-QAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
+G I + A +D E+Q +Y L + A D G + T V ++++D+ND+ P+F+
Sbjct: 2119 HLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPI 2178
Query: 966 YTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-------------TFQNGEDGDGDFTI 1012
T V E A P T + I+A D D N +++Y N ED F +
Sbjct: 2179 QTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDA---FAV 2233
Query: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSI-----QVMVQDVNDNAPVF 1067
+G V ++RE V+ YE+T +D VS+ V V DVNDN P F
Sbjct: 2234 NINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF 2293
Query: 1068 P---AEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQM-DIFSGE 1123
+ R+ E + G+ + + AVDPD+G N + Y +++ P Q+ D +G+
Sbjct: 2294 KPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGK 2353
Query: 1124 LTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYV 1180
+ A +DYE V+A+ S P + V++ +VD NDN+P+ + +Y
Sbjct: 2354 VIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ-----PSYQ 2408
Query: 1181 SNRSDTFPSG-IIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNR 1238
+ P G II + A D D + + G+ +N T+G++ + LD +
Sbjct: 2409 EAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREK 2467
Score = 380 bits (976), Expect = e-104
Identities = 282/874 (32%), Positives = 433/874 (49%), Gaps = 67/874 (7%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVL----RVVAQDPDAGEAGRLVYSLAALMNSRSLEL 375
+ HP F + YQ V EN AGT + ++A D D + Y L + L
Sbjct: 1954 DNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG----L 2009
Query: 376 FSIDPQSGL--IRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVF 433
F I+ +G+ +R+ +DRE+ L + L++T + +T+ D ND+ P F
Sbjct: 2010 FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTF 2069
Query: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSG 493
A L EN G+ +LQ+ ATD D+ N L YR A A F I +G
Sbjct: 2070 SPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGAQDRFLIHLVTG 2123
Query: 494 LIST-SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA 552
+I + +DRE ESY L V A+D+G P S T V I + D ND+ P+F
Sbjct: 2124 VIRVGNATIDREEQESYRLTVVATDRGTV--PLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIIS-----------GNSRGHFAIDSLTGE 601
V E P TV+ +TA D D N + Y+I+ N FA++ TG
Sbjct: 2182 SVLESAEPGTVIANITAIDH--DLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
Query: 602 IQVVAPLDFEAEREYALRI----RAQDAGRPPLSNNTGLASIQVVDINDHIPIFVS---T 654
+ V +P++ E Y + + A D +S ++ V+D+ND+ P F T
Sbjct: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
Query: 655 PFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVI-NSATGWVSVSGP 713
+ +LE A G ++I + AVD D G N + Y+L + P + +S+ G V +
Sbjct: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359
Query: 714 LDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGT 773
+D E V F V A D+GSPP +A V + ++D+NDN P F Y + ED VGT
Sbjct: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
Query: 774 SVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTA 833
+++VTA D D+ + + + G+ ++FAI+ G + + LD +++ ++ L A
Sbjct: 2420 IILTVTATDADSGNFALIEYSLGDGESKFAINPT--TGDIYVLSSLDREKKDHYILTALA 2477
Query: 834 SD-------RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDD 886
D + V I + D N RP F +S SV E+ P G++++ + A+D D
Sbjct: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD 2537
Query: 887 VGENARITYLLE-DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTT 945
G N +TY LE + F +D DSG +T Q PL ++ ++L + A D G P TT
Sbjct: 2538 EGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTT 2595
Query: 946 YVEVMVNDVNDNAPQFVASHYTGL--VSEDAPPFTSVLQISATDRDAHANGRVQYTFQNG 1003
+ V V DVNDN P FV + + E+ P ++V ++ ATD+D NG V+Y+F
Sbjct: 2596 MLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK- 2654
Query: 1004 EDGDGD---FTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVP-PLRTPVSIQVMVQD 1059
G+ D F I+P SG+++T +RLDRE+ +VY L A D G P P T +QV ++D
Sbjct: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 2714
Query: 1060 VNDNAPVF-----PAEEFE-VRVKENSIVGSVVAQIT-AVDPDEGPNAHIMYQIVEGNIP 1112
++DN P+F + +++ + V E+S G++V +T AVD DEGPNA + Y I GN
Sbjct: 2715 IDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEE 2774
Query: 1113 ELFQMDIFSGELTALIDLDYEARQEYVIVVQATS 1146
+ F + G L L DLD E + +V+A+S
Sbjct: 2775 KNFHLQP-DGCLLVLRDLDREREAIFSFIVKASS 2807
Score = 370 bits (949), Expect = e-101
Identities = 293/918 (31%), Positives = 451/918 (49%), Gaps = 71/918 (7%)
Query: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
+PE+ G V V A DPDAG G++V+SLA+ + + E+ + + G + A LDR
Sbjct: 1428 IPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDR 1487
Query: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQA-QYRETLRENVEEGYPI 452
E ++ + L+V A D G+P ++ VT+ D ND+ PV E Y ++ ENV G +
Sbjct: 1488 EELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
Query: 453 LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST-SGRVDREHMESYEL 511
+Q+RATD D N+ L Y AF +D SG I+T DRE Y L
Sbjct: 1548 VQVRATDRDIGINSVLSYYI-----TEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHL 1602
Query: 512 VVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTV---VLRVT 568
V D+G SAT V++T++DENDNAP F + Y +V D P T+ ++ +
Sbjct: 1603 VATVEDEGTP--TLSATTHVYVTIVDENDNAPMFQQPHY--EVLLDEGPDTLNTSLITIQ 1658
Query: 569 ATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFE-AEREYALRIRAQDAGR 627
A D D+ NG V Y I++GN F ID G I LD+E + Y L + A D
Sbjct: 1659 ALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQ-C 1717
Query: 628 PPLSN---NTGLASIQVVDINDHIPIF---VSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
P LS+ +T + V DIND++P F PF+V+ E P G V A D D G
Sbjct: 1718 PILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVT--EGQP-GPRVWTFLAHDRDSG 1774
Query: 682 ENARLEYSLTGVAPDTPFVINSATGWVSV--SGPLDRESVEHYFFGVEARDHGSPPLSAS 739
N ++EYS+ P FVI+ G + V LDRE++ Y + ARD G PPLS++
Sbjct: 1775 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSST 1834
Query: 740 ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGGN 797
V + VLD+NDN P ++ ++E++ V + V V A D D+ N+ +++ IT GN
Sbjct: 1835 MLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGN 1894
Query: 798 TRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR------ALHDHCYVHINITDA 851
F I+ G+VT+ PLD ++ +KL ++ D A D+ + I ++D
Sbjct: 1895 RERAFFINAT--TGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDE 1952
Query: 852 NTHRPVFQSAHYSVSVNEDRPMGSTIVVIS----ASDDDVGENARITY-LLEDNLPQFRI 906
N + P+F + Y V E+ P G+ + V++ A D D A +TY LL F I
Sbjct: 1953 NDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDI 2012
Query: 907 DADSGAITLQAPLDYEDQV----TYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFV 962
++ +G +T+++ + + + L + A D G+ T ++ + + D NDN P F
Sbjct: 2013 NSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLN--STAHLLITILDDNDNRPTFS 2070
Query: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
+ T + E+ PP SVLQ++ATD D+ NG + Y + G F I +G++R
Sbjct: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG--AQDRFLIHLVTGVIRVG 2128
Query: 1023 R-RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSI 1081
+DRE Y LT A DRG PL + +++ D+ND+ P F V V E++
Sbjct: 2129 NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
Query: 1082 VGSVVAQITAVDPDEGPNA--HIMYQIVEG-------NIPELFQMDIFSGELTALIDLDY 1132
G+V+A ITA+D D P HI+ + + N + F ++I +G + ++
Sbjct: 2189 PGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNR 2248
Query: 1133 EARQEYVIVV----QATSAP----LVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSN-R 1183
E Y + + A+ P V A + V ++D NDN+P F I + Y+
Sbjct: 2249 ELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY--YMERIL 2306
Query: 1184 SDTFPSGIIGRIPAYDPD 1201
P + + A DPD
Sbjct: 2307 EGATPGTTLIAVAAVDPD 2324
Score = 362 bits (930), Expect = 3e-99
Identities = 279/883 (31%), Positives = 423/883 (47%), Gaps = 48/883 (5%)
Query: 323 PQFPQYNYQTLVPENEAAGTAV---LRVVAQDPDAGEAGRL-VYSLAALMNSRSLELFSI 378
P+F Y + E G A+ ++VV +D + G VY + + + S+
Sbjct: 346 PEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSV 405
Query: 379 DPQSGL-IRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
++ + IR A LD E+++R+ + A + P V +T+ + ND+ P+F Q
Sbjct: 406 QGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPL 464
Query: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Y +L ENV G +L + ATD DA + Y F P F +D +GLI
Sbjct: 465 YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP-------DRFSLDKDTGLIML 517
Query: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
R+D E ++ + L + A D G E T RV I VLD NDN P F + YV +RE+
Sbjct: 518 IARLDYELIQRFTLTIIARDGGGE----ETTGRVRINVLDVNDNVPTFQKDAYVGALREN 573
Query: 558 VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSL---TGEIQVVAPLDFE--A 612
T ++R+ ATD D N + Y+I+S ++ G + SL G I V PLD+E +
Sbjct: 574 EPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQIS 633
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
L + A DAG PPL N+T +I+V D ND+ P F + VSV+EN G +V+
Sbjct: 634 NGLIYLTVMAMDAGNPPL-NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLF 692
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDH- 731
+ A D D E + + T F IN+ +G ++ + LDRE+ Y V A D
Sbjct: 693 LNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGG 752
Query: 732 -GSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSA 788
G + A+V +T+LD+NDN P + Y++ L E + V +V AVD D N
Sbjct: 753 VGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGT 812
Query: 789 ISYQITGGNTRNRFAISTQGGVGLVTLAL-----PLDYKQERYFKLVLTASD-----RAL 838
+ Y I N +++++ G T A+ P ++ E K+V++ +D
Sbjct: 813 LVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870
Query: 839 HDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE 898
V +N+ D N + P FQ+ + V E P G +I + A D D G N ++Y +
Sbjct: 871 TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
Query: 899 DNLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
+P+ F I++ SG + LD E Y L + A D G P K+ T+ + + V DVND
Sbjct: 931 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVND 990
Query: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTS 1016
P F + Y VSED P V+ ++ TD D N + Y F G + DG F++
Sbjct: 991 ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY-FITGGNVDGKFSVGYRD 1049
Query: 1017 GIVRTVRRLDREAVSVYELTAYAVDRGVPPLR--TPVSIQVMVQDVNDNAPVFPAEEFEV 1074
+VRTV LDRE + Y L A+D G R ++ V V DVNDN P+F +E
Sbjct: 1050 AVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEA 1109
Query: 1075 RVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGEL-TALIDLDYE 1133
V E+ G + Q+ A D DEG + Y+I+ GN F++ + +G L LD E
Sbjct: 1110 SVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRE 1169
Query: 1134 ARQEYVIVVQATS---APLVSRATVHVRLVDQNDNSPVLNNFQ 1173
+V++V+A + P+ S V V + D ND +PV Q
Sbjct: 1170 RNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1212
Score = 362 bits (928), Expect = 4e-99
Identities = 319/1059 (30%), Positives = 504/1059 (47%), Gaps = 89/1059 (8%)
Query: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
+ EN + V V+A D D+G RL +++ A R+ F I+ +G++ LDR
Sbjct: 1860 ISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERA---FFINATTGIVTVNRPLDR 1916
Query: 394 ESMERHYLRVTAQDHG-SPRLSATT--MVAVTVADRNDHSPVFEQAQYRETLRENVEEGY 450
E + + L ++ +D+ +PR++ ++ + ++D ND+ P+F ++ Y+ + EN G
Sbjct: 1917 ERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT 1976
Query: 451 PILQLR----ATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV--DRE 504
P+ L A D D A + Y+ +G A + F+I+ +G+++ V DRE
Sbjct: 1977 PLTVLNGPILALDADQDIYAVVTYQLLG------AQSGLFDINSSTGVVTVRSGVIIDRE 2030
Query: 505 HMES--YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
EL++ A D G ++T + IT+LD+NDN P FS + E+ P
Sbjct: 2031 AFSPPILELLLLAEDIGL----LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGF 2086
Query: 563 VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVV-APLDFEAEREYALRIR 621
VL+VTATD D NG + Y I +G ++ F I +TG I+V A +D E + Y L +
Sbjct: 2087 SVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVV 2145
Query: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
A D G PLS T + +I + DIND P F++ VSVLE+A G + +I A+D H
Sbjct: 2146 ATDRGTVPLSG-TAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAID--HD 2202
Query: 682 ENARLEYSLTGVAP-----------DTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
N +LEY + G+ + F +N TG V V P++RE V Y + D
Sbjct: 2203 LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVID 2262
Query: 731 HGS--PPLSAS---ASVTVTVLDVNDNRPEFT---MKEYHLRLNEDAAVGTSVVSVTAVD 782
+ S P S S A +TV VLDVNDN P+F + Y R+ E A GT++++V AVD
Sbjct: 2263 NASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVD 2322
Query: 783 RDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHD 840
D N ++Y + + G V +DY++ + + ASD
Sbjct: 2323 PDKGLNGLVTYTLLDLVPPGYVQLE-DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPP 2381
Query: 841 HCY---VHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL 897
V++ I D N + P+F Y +V ED P+G+ I+ ++A+D D G A I Y L
Sbjct: 2382 RAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL 2441
Query: 898 EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDN----GIPQKADTTYVEVMVND 953
D +F I+ +G I + + LD E + Y L A+DN ++ ++ V + V D
Sbjct: 2442 GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLD 2501
Query: 954 VNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIE 1013
VND PQF ++ V E+ P TSV+ + ATD+D NG + Y+ + G F ++
Sbjct: 2502 VNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEG--PGVEAFHVD 2559
Query: 1014 PTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF--PAEE 1071
SG+V T R L ++ + LT A D G PPL + V V DVNDN PVF P
Sbjct: 2560 MDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNG 2617
Query: 1072 FEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVE--GNIP-ELFQMDIFSGELTALI 1128
+ ++E + S V ++ A D DEG N + Y ++ GN E F +D SG +
Sbjct: 2618 TILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQ 2677
Query: 1129 DLDYEARQEYVIVVQATS----APLVSRATVHVRLVDQNDNSPVL-------NNFQILFN 1177
LD E++ Y +++ A+ P + + V L D +DN P+ +Q+L
Sbjct: 2678 RLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2737
Query: 1178 NYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNN 1237
S R T + G + A D + ++Y GNE + + Q G L + R LD
Sbjct: 2738 PEHSPRG-TLVGNVTGAVDA-DEGPNAIVYYFIAAGNEEKNFHL-QPDGCLLVLRDLDRE 2794
Query: 1238 RPLVASMLVTVTDGLHSVTAQCVLRVVIITEELLANSLTVRLENMWQE--RFLSPLLGRF 1295
R + S +V + + + + +L + V LE++ + RF +
Sbjct: 2795 REAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTK---AEY 2851
Query: 1296 LEGVAAVLATPAEDVFIFNIQNDTDVGGTVLNVSFSALA 1334
GVA +E + + + D D+G L V +S LA
Sbjct: 2852 TAGVATDAKVGSELIQVLAL--DADIGNNSL-VFYSILA 2887
Score = 348 bits (893), Expect = 5e-95
Identities = 281/905 (31%), Positives = 449/905 (49%), Gaps = 86/905 (9%)
Query: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
+ E+ G + QL A D D P L + G A+R F ++P +G++ +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRF-----FAVEPDTGVVWLRQPL 93
Query: 502 DREHMESYELVVEASD-QGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRP 560
DRE + + SD QG T +V+I V D NDNAP F + Y ++ E+
Sbjct: 94 DRETKSEFTVEFSVSDHQGV------ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
Query: 561 HTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRI 620
T + V ATD D A G V Y+ + FAIDS G + V+ LD+E + Y L +
Sbjct: 148 GTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTV 205
Query: 621 RAQDAGRP-PLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
A D + PLS LA I + D+ D PIF++ P+ ++ E++P G +V I A+D D
Sbjct: 206 NATDQDKTRPLSTLANLAII-ITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
Query: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRES--VEHYFF----GVEARDHGS 733
G + Y++ ++ F ++ +G ++++G LDRE+ H F G E D +
Sbjct: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
Query: 734 PPLSASASVTVT----VLDVNDNRPEFTMKEYHLRLNEDAAVGTSV-VSVTAVDRDANSA 788
P + A+VT T V+D+NDN PEF EY + + E A VG ++ + + VD+D N
Sbjct: 325 P---SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLG 381
Query: 789 ISYQI---TGGNTRNRFAI---STQGGVGL-VTLALPLDYKQERYFKLVLTASDRALHDH 841
++ GN + F I S QG + + +A+PLDY+ + L A++ ++ DH
Sbjct: 382 LNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDH 440
Query: 842 ---CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE 898
V I + + N +RP+F Y++S+ E+ +G++++ + A+D+D G ++Y
Sbjct: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS 500
Query: 899 DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNA 958
D+ +F +D D+G I L A LDYE +TL I ARD G + T V + V DVNDN
Sbjct: 501 DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNV 558
Query: 959 PQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDG--DFTIEPTS 1016
P F Y G + E+ P T ++++ ATD D+ N ++ Y+ + D ++
Sbjct: 559 PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY 618
Query: 1017 GIVRTVRRLDREAVS--VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEV 1074
G++ R LD E +S + LT A+D G PPL + V + + V D NDN P F + V
Sbjct: 619 GVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV 678
Query: 1075 RVKENSIVGSVVAQITAVDPD---EGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
V EN + G+ V + A D D E I+Y + EG+ F+++ SGE+T LD
Sbjct: 679 SVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ--FRINARSGEITTTSLLD 735
Query: 1132 YEARQEYVIVVQATSAPL-----VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDT 1186
E + EY+++V+A + ATV++ L+D NDN P + Y++ T
Sbjct: 736 RETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPY----YINLVEMT 791
Query: 1187 FPSGIIGRIPAYDPDVSDH--LFYSFERGNELQLLVVNQTSGELRLSR-KLDNNRP---- 1239
P + + A DPD+ ++ L YS + N+ L N T+G++R + LD P
Sbjct: 792 PPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL--NSTTGKIRTTHAMLDRENPDPHE 849
Query: 1240 --LVASMLVTVTD-GLHSVTAQCVLRVVIITEELLANSLTVRLENMWQERFLSPLLGRFL 1296
L+ ++V+VTD G + A V + +L N T +N+ P + L
Sbjct: 850 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT--FQNL-------PFVAEVL 900
Query: 1297 EGVAA 1301
EG+ A
Sbjct: 901 EGIPA 905
Score = 335 bits (859), Expect = 4e-91
Identities = 292/996 (29%), Positives = 463/996 (46%), Gaps = 76/996 (7%)
Query: 320 NRHPQFPQYNYQT--LVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
NR P F + + T L+ E+ G++V +++AQD D LV+ ++ SR F+
Sbjct: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASR---FFA 79
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
++P +G++ LDRE+ + + DH T V + V D ND++P F
Sbjct: 80 VEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQP 136
Query: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Y + EN G PI + ATD D ++ Y F P + F ID G+++
Sbjct: 137 YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP-------SQFFAIDSARGIVTV 189
Query: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
+D E ++Y+L V A+DQ + P S + I + D D P F Y + E
Sbjct: 190 IRELDYETTQAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH 248
Query: 558 VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFE---AER 614
P T V +TA D+DK + Y I+SGN+ FA+D ++G + + LD E
Sbjct: 249 SPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSH 308
Query: 615 EYALRIRA---QDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV- 670
+ L ++ D P + T +I V+DIND+ P F S+ + V++ E A +G ++
Sbjct: 309 GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALP 368
Query: 671 IHIQAVDADH--GENARLEYSLTG-------VAPDTPFVINSATGWVSVSGPLDRESVEH 721
+ IQ VD D G N+ E L G ++P + V A + V+ PLD E+V+
Sbjct: 369 LFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTS--VQGKADIRIRVAIPLDYETVDR 426
Query: 722 YFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781
Y F + A + P A V +T+++ NDNRP F+ Y++ L E+ VGTSV++V A
Sbjct: 427 YDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLAT 485
Query: 782 DRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH 841
D DA + + +RF++ GL+ L LDY+ + F L + A D +
Sbjct: 486 DNDAGTFGEVSYFFSDDPDRFSLDKD--TGLIMLIARLDYELIQRFTLTIIARDGGGEET 543
Query: 842 C-YVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED- 899
V IN+ D N + P FQ Y ++ E+ P + +V + A+D+D N +ITY +
Sbjct: 544 TGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSA 603
Query: 900 ----NLPQFRIDADSGAITLQAPLDYE--DQVTYTLAITARDNGIPQKADTTYVEVMVND 953
+ + G I++ PLDYE L + A D G P T V + V D
Sbjct: 604 SAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFD 663
Query: 954 VNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIE 1013
NDN P F Y V E+ +VL ++ATD D + Q + +G F I
Sbjct: 664 ENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLD-RSREYGQESIIYSLEGSTQFRIN 722
Query: 1014 PTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTP--VSIQVMVQDVNDNAPVFPAEE 1071
SG + T LDRE S Y L AVD GV + ++ + + D+NDN P +
Sbjct: 723 ARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAP 782
Query: 1072 FEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELT---ALI 1128
+ + + E + S V + AVDPD G N ++Y I N + + ++ +G++ A++
Sbjct: 783 YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAML 840
Query: 1129 DLD----YEARQEYVIVVQATSA---PL--VSRATVHVRLVDQNDNSPVLNNFQILFNNY 1179
D + +EA IVV T PL S ATV V L+D NDN P N +
Sbjct: 841 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLP-----F 895
Query: 1180 VSNRSDTFPSGI-IGRIPAYDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDN 1236
V+ + P+G+ I ++ A D D ++ + Y G ++N +SG + + +LD
Sbjct: 896 VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDR 955
Query: 1237 NRPLVASMLVTVTDG---LHSVTAQCVLRVVIITEE 1269
R + V +D S T+ + V+ + +E
Sbjct: 956 ERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDE 991
Score = 320 bits (820), Expect = 1e-86
Identities = 258/839 (30%), Positives = 394/839 (46%), Gaps = 67/839 (7%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ P F + EN G +VL+V A D D+G G LVY + A R F I
Sbjct: 2064 DNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR----FLIH 2119
Query: 380 PQSGLIRTA-AALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQY 438
+G+IR A +DRE E + L V A D G+ LS T +V + + D ND P F
Sbjct: 2120 LVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
Query: 439 RETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAA------AAAAFEIDPRS 492
++ E+ E G I + A D D N L Y VG A AF ++ +
Sbjct: 2180 TVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINT 2237
Query: 493 GLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV---RVHITVLDENDNAPQFSE-- 547
G + ++RE + +YE+ + D + RS +V ++ + VLD NDN PQF
Sbjct: 2238 GSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFG 2297
Query: 548 -KRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAI-DSLTGEIQVV 605
Y+ ++ E P T ++ V A D DK NGLV Y ++ G+ + DS G++
Sbjct: 2298 ITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIAN 2357
Query: 606 APLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAP 665
+D+E +RA D G PP + + +++VDIND+ PIF +Q +V E+ P
Sbjct: 2358 RTVDYEEVHWLNFTVRASDNGSPPRAAEIPV-YLEIVDINDNNPIFDQPSYQEAVFEDVP 2416
Query: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
+G ++ + A DAD G A +EYSL ++ F IN TG + V LDRE +HY
Sbjct: 2417 VGTIILTVTATDADSGNFALIEYSLGD--GESKFAINPTTGDIYVLSSLDREKKDHYILT 2474
Query: 726 VEARDH----GSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781
A+D+ S S V + VLDVND RP+F+ ++ + E+ GTSV+++ A
Sbjct: 2475 ALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMAT 2534
Query: 782 DRD--ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-- 837
D+D N ++Y + G A GLVT PL ++ F L + A+D
Sbjct: 2535 DQDEGPNGELTYSLEGPGVE---AFHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEP 2589
Query: 838 -LHDHCYVHINITDANTHRPVFQSAHYS--VSVNEDRPMGSTIVVISASDDDVGENARIT 894
L + + + D N +RPVF + + E+ P+ S + + A+D D G N +
Sbjct: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVR 2649
Query: 895 YLL-----EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTY-VE 948
Y + F ID SG I LD E Q Y+L + A D G P +T ++
Sbjct: 2650 YSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQ 2709
Query: 949 VMVNDVNDNAPQFV-----ASHYTGL-VSEDAPPFTSVLQIS-ATDRDAHANGRVQYTFQ 1001
V + D++DN P FV + Y L V E +P T V ++ A D D N V Y
Sbjct: 2710 VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIA 2769
Query: 1002 NGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-VDRGVPPLRTP---------- 1050
G + + +F ++P G + +R LDRE +++ A +R P R P
Sbjct: 2770 AGNE-EKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827
Query: 1051 --VSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIV 1107
++V+++D+ND P F E+ V ++ VGS + Q+ A+D D G N+ + Y I+
Sbjct: 2828 TLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
Score = 171 bits (433), Expect = 1e-41
Identities = 136/392 (34%), Positives = 193/392 (49%), Gaps = 31/392 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
PQF + + T V ENE AGT+V+ ++A D D G G L YSL +E F +D S
Sbjct: 2507 PQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL----EGPGVEAFHVDMDS 2562
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
GL+ T L +S E+ L V A D G P L TTM+ V V D ND+ PVF + L
Sbjct: 2563 GLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
Query: 443 --RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGR 500
RE + + ++ ATD D N +RY F+ R F IDP SGLI T+ R
Sbjct: 2621 HIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNR--DWEFFIIDPISGLIQTAQR 2678
Query: 501 VDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQF------SEKRYVAQV 554
+DRE Y L++ ASD GQ P P + + + D +DN P F S + + V
Sbjct: 2679 LDRESQAVYSLILVASDLGQ-PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2737
Query: 555 REDVRPHTVVLRVT-ATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAE 613
E T+V VT A D D+ N +V+Y I +GN +F + G + V+ LD E E
Sbjct: 2738 PEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDRERE 2796
Query: 614 REYALRIRAQD--AGRPP--------LSNNTGLASIQVV--DINDHIPIFVSTPFQVSVL 661
++ ++A + PP L + L ++VV DIND P F + V
Sbjct: 2797 AIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVA 2856
Query: 662 ENAPLGHSVIHIQAVDADHGENARLEYSLTGV 693
+A +G +I + A+DAD G N+ + YS+ +
Sbjct: 2857 TDAKVGSELIQVLALDADIGNNSLVFYSILAI 2888
Score = 47.8 bits (112), Expect = 2e-04
Identities = 54/191 (28%), Positives = 81/191 (42%), Gaps = 23/191 (12%)
Query: 326 PQYNYQTLVPENEAAGTAVLRVV-AQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGL 384
PQY T VPE+ GT V V A D D G + Y +AA ++ F + P G
Sbjct: 2730 PQYQLLT-VPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKN---FHLQPD-GC 2784
Query: 385 IRTAAALDRESMERHYLRVTAQDHGS---PRLSATTM----------VAVTVADRNDHSP 431
+ LDRE V A + S PR + T+ V V + D ND P
Sbjct: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
Query: 432 VFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPR 491
F +A+Y + + + G ++Q+ A D D N+ + Y + RA A + ++
Sbjct: 2845 RFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDV--- 2901
Query: 492 SGLISTSGRVD 502
G + T G +D
Sbjct: 2902 -GQVFTMGSMD 2911
Score = 33.9 bits (76), Expect = 2.8
Identities = 19/73 (26%), Positives = 37/73 (50%), Gaps = 8/73 (10%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSL--------E 374
P+F + Y V + G+ +++V+A D D G + YS+ A+ R+L +
Sbjct: 2844 PRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQ 2903
Query: 375 LFSIDPQSGLIRT 387
+F++ G++RT
Sbjct: 2904 VFTMGSMDGILRT 2916
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 378 bits (971), Expect = e-104
Identities = 275/847 (32%), Positives = 420/847 (49%), Gaps = 30/847 (3%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ P F Y+ ++ EN GT+V++V A D D G G++ Y L+A S ELF+ID
Sbjct: 2792 DNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAID 2851
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSP-RLSATTMVAVTVADRNDHSPVFEQAQY 438
+SG I T LD E+ + ++ V A DHG +LS+ +V V++ D ND++P F +Y
Sbjct: 2852 SESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEY 2911
Query: 439 RETLRENVEEGYPILQLRATDGD-APPNANLR-YRFVGPPAARAAAAAAFEIDPRSGLIS 496
R ++ EN E G + L+ D D + N + Y G P + + + IS
Sbjct: 2912 RGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGD----EWRIS 2967
Query: 497 TSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE 556
+ +DREH Y L V ASD G A+V V I VLD NDN+PQ S+ Y +V E
Sbjct: 2968 SRKTLDREHTAKYLLRVTASD-----GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHE 3022
Query: 557 DVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREY 616
DV P +L+V+ATD D D N + Y+ + G F +D TGE+ + LD E + +
Sbjct: 3023 DVFPGHFILKVSATDLDTDTNAQITYS-LHGPGAHEFKLDPHTGELTTLTALDRERKDVF 3081
Query: 617 ALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAV 676
L +A D G + ++ V D+ND+ P F + V+V +N + V + A
Sbjct: 3082 NLVAKATDGGGRSCQAD---ITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFAR 3138
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP-P 735
D D G NA++ YSL A + F I++ TG + + PL V A D G+P P
Sbjct: 3139 DPDQGANAQVVYSLPDSA-EGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIP 3197
Query: 736 LSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITG 795
LS +VTV+V+ + D P F E+ +++ EDA GT V+ + + R Y++
Sbjct: 3198 LSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVS 3257
Query: 796 GNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLT-ASDRALHDHCYVHINITDANTH 854
GN + RF + + G+ V +L + + + + + S +L D V +NITD N H
Sbjct: 3258 GNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEH 3317
Query: 855 RPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL--EDNLPQFRIDADSGA 912
RP F YS V E+ +G I+ +SA+D+D N+ ITY L + L F I G
Sbjct: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGE 3377
Query: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972
+ + LD E +Y+L + A D+G P + T + + V DVNDN P+F +Y+ V E
Sbjct: 3378 LQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQE 3437
Query: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGD-FTIEPTSGIVRTVRRLDREAVS 1031
++P + VLQ+ +D D+ NG Y+F+ + +G F + P +V T L R A
Sbjct: 3438 NSPIGSKVLQLILSDPDSPENG-PPYSFRITKGNNGSAFRVTPDGWLV-TAEGLSRRAQE 3495
Query: 1032 VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITA 1091
Y+L A D G+PPL + S++V V + + AP E + V E+ G +V +I A
Sbjct: 3496 WYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHA 3555
Query: 1092 VDPDEGPNAHIMYQIV-EGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLV 1150
D D P + Y + E + F + G++ A L R Y V +
Sbjct: 3556 TDRD--PQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGL---PRGHYSFNVTVSDGTFT 3610
Query: 1151 SRATVHV 1157
+ A VHV
Sbjct: 3611 TTAGVHV 3617
Score = 369 bits (947), Expect = e-101
Identities = 297/1005 (29%), Positives = 471/1005 (46%), Gaps = 91/1005 (9%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
N P F + +Y + EN GT+VL V A D D GE G + YS+A ++L FSID
Sbjct: 453 NHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAG---PKALP-FSID 508
Query: 380 PQSGLIRTAAALDRESMERHY-LRVTAQDHGSP-RLSATTMVAVTVADRNDHSPVFEQAQ 437
P G+I T+ +D E M+R Y RV A D GSP R + + + + ND+ P+FE+
Sbjct: 509 PYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVN 568
Query: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
++R++ G I+ + A D D N L+Y V F+++ SG+IS
Sbjct: 569 CTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVS-----GNELEYFDLNHFSGVISL 621
Query: 498 SG---RVDREHMESYELVVEASDQGQEPGPRSATVRV----------------------- 531
+ SY L + ASD P + + V
Sbjct: 622 KRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTK 681
Query: 532 -------------------HITVLDENDNAPQFSEK-RYVAQVREDVRPHTVVLRVTATD 571
++ N PQF + V E V +T + R+ ATD
Sbjct: 682 TILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATD 741
Query: 572 RDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLS 631
D NG + Y I GN G F I+ TG + V APLD+EA Y L + D G P S
Sbjct: 742 PDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKS 801
Query: 632 NNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLT 691
+ L ++ V D ND+ P F +Q+++ E+ +G ++ + DAD +N R+ Y+L
Sbjct: 802 S-WKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL- 859
Query: 692 GVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP--PLSASASVTVTVLDV 749
++P F ++ TG + V+G LDRES Y VEARD S L + + +T+ DV
Sbjct: 860 -LSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDV 918
Query: 750 NDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA--ISYQITGGNTRNRFAISTQ 807
NDN P+ + L++ ED GT + + A D D A + Y + G F +
Sbjct: 919 NDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLM 977
Query: 808 GGVGLVTLALPLDYKQERYFKLVLTASDR----ALHDHCYVHINITDANT--HRPVFQSA 861
G + L LD+++ + L L ASD A C+V + + D N H P F S
Sbjct: 978 --TGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASF 1035
Query: 862 HYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLPQFRIDADSGAITLQAPL 919
+ V E+ P G+ ++V++A DDD G + + Y L L F I+ D+G I APL
Sbjct: 1036 VHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPL 1095
Query: 920 DYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTS 979
D E Y L + A D G + T V + V D NDN PQ + + + EDAP TS
Sbjct: 1096 DREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTS 1155
Query: 980 VLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA 1039
VLQ+ A D D+ + G++ + +G + G F I P +G++ T ++LDRE + L
Sbjct: 1156 VLQLDAWDPDSSSKGKLTFNITSG-NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV 1214
Query: 1040 VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKE--NSIVGSVVAQITAVDPDEG 1097
+D G P L++ + V + DVNDN P+F + F VR+ E + + V ++ A D DEG
Sbjct: 1215 LDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEG 1274
Query: 1098 PNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA---PLVSRAT 1154
N + Y I E + E F +D+ +G +++ + A + ++ ++AT + PL +
Sbjct: 1275 LNGRVTYSI-EDSDEEAFSIDLVTGVVSS--SSTFTAGEYNILTIKATDSGQPPLSASVR 1331
Query: 1155 VHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYD-PDVSDHLFYSFERG 1213
+H+ + S + F + ++ +D + ++G I P + +++ G
Sbjct: 1332 LHIEWIPWPRPSSIPLAFDETYYSFTVMETDPV-NHMVGVISVEGRPGL---FWFNISGG 1387
Query: 1214 NELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQ 1258
++ + +T+G + ++R LD R ++ V VTDG ++ Q
Sbjct: 1388 DKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQ 1432
Score = 369 bits (946), Expect = e-101
Identities = 286/955 (29%), Positives = 471/955 (49%), Gaps = 51/955 (5%)
Query: 319 ANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
AN++ P+F Q+ Y+ + EN GT V+ ++A D D+G G + Y++ +N + E FS
Sbjct: 2474 ANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI---INKLASEKFS 2530
Query: 378 IDPQSGLIRTAAALDRESMERHYL--RVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
I+P +G I T LDRE+ + +V A+D G T + +T D ND+ P F+
Sbjct: 2531 INP-NGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILT--DENDNPPQFKA 2587
Query: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
++Y +++ NV + P++Q+ A D D NA++ Y V P EI+P +G++
Sbjct: 2588 SEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYS-VNP---EDLVKDVIEINPVTGVV 2643
Query: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVR 555
+ ++ + ++A D G P ++ V V + V+ + + P+FSE Y
Sbjct: 2644 KVKDSLVGLENQTLDFFIKAQDGG--PPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAP 2701
Query: 556 EDVRPHTVVLRVTA-TDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAER 614
ED+ + + V A +D LV N G F++D TG I+V P+D E+ +
Sbjct: 2702 EDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTK 2761
Query: 615 EYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQ 674
Y + + A + + + +IQV D+ND+ P+F + P++ + EN P+G SVI +
Sbjct: 2762 LYQIDVMAHCLQNTDVVSLVSV-NIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVT 2820
Query: 675 AVDADHGENARLEYSLT---GVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDH 731
A+D D G + ++ Y L+ G F I+S +GW++ LD E+ + Y F V A DH
Sbjct: 2821 AIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDH 2880
Query: 732 GSP-PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD---ANS 787
G LS+ A V V++ D NDN P F +EY + E++ G V ++ +D D N
Sbjct: 2881 GQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNR 2940
Query: 788 AISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHIN 847
++ IT G+ +F IS G ++ LD + + L +TASD V I
Sbjct: 2941 QVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIF 3000
Query: 848 ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE-DNLPQFRI 906
+ D N + P Y+ V+ED G I+ +SA+D D NA+ITY L +F++
Sbjct: 3001 VLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKL 3060
Query: 907 DADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHY 966
D +G +T LD E + + L A D G ++ + + V DVNDNAP+F SH
Sbjct: 3061 DPHTGELTTLTALDRERKDVFNLVAKATDGG--GRSCQADITLHVEDVNDNAPRFFPSHC 3118
Query: 967 TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLD 1026
V ++ T V + A D D AN +V Y+ + +G F+I+ T+G++R + L
Sbjct: 3119 AVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLP--DSAEGHFSIDATTGVIRLEKPLQ 3176
Query: 1027 REAVSVYELTAYAVDRGVP-PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSV 1085
+ ELT A D G P PL T ++ V V + D PVF E V+V E++ G+
Sbjct: 3177 VRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTE 3236
Query: 1086 VAQITAVDPDEGPNAH-IMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQA 1144
V Q+ + P A Y++V GN F++D +G L LD+E +Y + ++
Sbjct: 3237 VLQLATL---TRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIEC 3293
Query: 1145 ---TSAPLVSRATVHVRLVDQNDNSPVL----NNFQILFNNYVSNRSDTFPSGIIGRIPA 1197
+S+ L TV V + D N++ P + ++L N V + +I + A
Sbjct: 3294 SRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGD--------VILTVSA 3345
Query: 1198 YDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
D D ++ + YS GN+L ++ GEL++++ LD + S+ + TD
Sbjct: 3346 TDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATD 3400
Score = 364 bits (935), Expect = e-100
Identities = 310/1089 (28%), Positives = 490/1089 (44%), Gaps = 63/1089 (5%)
Query: 323 PQFPQYNYQTLVPENEAAGTA---VLRVVAQDPDAGEAGRLVYSLAALMNSRSLE--LFS 377
P+F + Y PE+ G+ V V AQDP ++YSL S + +FS
Sbjct: 2689 PKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDP-------VIYSLVRGTTPESNKDGVFS 2741
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
+DP +G+I+ +D ES + + + V A + + + V + V D ND+ PVFE
Sbjct: 2742 LDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADP 2801
Query: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Y+ L EN+ G ++Q+ A D D + + YR P + F ID SG I+T
Sbjct: 2802 YKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHEL--FAIDSESGWITT 2859
Query: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
+D E ++Y V A D GQ S+ V +++ DENDNAP+F+ + Y V E+
Sbjct: 2860 LQELDCETCQTYHFHVVAYDHGQTI-QLSSQALVQVSITDENDNAPRFASEEYRGSVVEN 2918
Query: 558 VRPHTVVLRVTATDRD-KDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA--PLDFEAER 614
P +V + D D + N V I G+ G F I + E ++ + LD E
Sbjct: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTA 2978
Query: 615 EYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQ 674
+Y LR+ A D G+ S I V+D+ND+ P + V E+ GH ++ +
Sbjct: 2979 KYLLRVTASD-GKFQASVTV---EIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVS 3034
Query: 675 AVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
A D D NA++ YSL G F ++ TG ++ LDRE + + +A D G
Sbjct: 3035 ATDLDTDTNAQITYSLHGPGAHE-FKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGR 3093
Query: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
S A +T+ V DVNDN P F + + ++ V T V V A D D AN+ + Y
Sbjct: 3094 --SCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYS 3151
Query: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA----LHDHCYVHINI 848
+ + F+I GV + L PL + + +L + ASD L V +++
Sbjct: 3152 LPD-SAEGHFSIDATTGV--IRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSV 3208
Query: 849 TDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDA 908
+ PVF + +SV V ED P G+ ++ ++ E + + +FR+DA
Sbjct: 3209 VGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDA 3268
Query: 909 DSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTG 968
+G + + A LD+E Y L+I +D T V V + DVN++ PQF Y+
Sbjct: 3269 RTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYST 3328
Query: 969 LVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDRE 1028
V E+A +L +SATD D N + Y+ G G FTI P G ++ + LDRE
Sbjct: 3329 RVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQ-LGHFTIHPKKGELQVAKALDRE 3387
Query: 1029 AVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQ 1088
S Y L A D G PPL I + V DVNDN P F + V+ENS +GS V Q
Sbjct: 3388 QASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQ 3447
Query: 1089 ITAVDPDEGPNA-HIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA 1147
+ DPD N ++I +GN F++ G L L A++ Y + +QA+ +
Sbjct: 3448 LILSDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRAQEWYQLQIQASDS 3506
Query: 1148 ---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSD 1204
PL S +V V + +Q+ +P +I +++ D F G++G+I A D D D
Sbjct: 3507 GIPPLSSLTSVRVHVTEQSHYAPSALPLEI----FITVGEDEFQGGMVGKIHATDRDPQD 3562
Query: 1205 HLFYSFERGNEL-QLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRV 1263
L YS L + V G++ ++ L S VTV+DG + TA + V
Sbjct: 3563 TLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGH---YSFNVTVSDGTFTTTAGVHVYV 3619
Query: 1264 VIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTDVGG 1323
+ +E L ++ + + E +S ++ L ++ + ++Q V G
Sbjct: 3620 WHVGQEALQQAMWMGFYQLTPEELVSDHWRNLQRFLSHKLDIKRANIHLASLQPAEAVAG 3679
Query: 1324 TVLNVSFSALAPRGAGAGAAGPWFSSEELQEQL------YVRRAALAARSLLDVLPFDDN 1377
+ + F G +G ++ +EL + + RS + ++P
Sbjct: 3680 VDVLLVFE---------GHSGTFYEFQELASIITHSAKEMEHSVGVQMRSAMPMVPCQGP 3730
Query: 1378 VCLREPCEN 1386
C + C N
Sbjct: 3731 TCQGQICHN 3739
Score = 356 bits (913), Expect = 2e-97
Identities = 295/952 (30%), Positives = 453/952 (47%), Gaps = 53/952 (5%)
Query: 323 PQFPQYNYQTL-VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQ 381
PQF + Q++ V E+ T + R+ A DPDAG G+LVY +A + F I+ +
Sbjct: 712 PQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIA---DGNEEGCFDIELE 768
Query: 382 SGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
+GL+ AA LD E+ + L VT D G+P+ S+ ++ V V D ND++P F Y+ T
Sbjct: 769 TGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLT 828
Query: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
+ E+ E G I +L D D+ N +RY + P F + P +G + +G +
Sbjct: 829 ISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSP-------TEKFSLHPLTGELVVTGHL 881
Query: 502 DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561
DRE Y L VEA DQ + + + IT+ D NDN+PQ + +V ED+ P
Sbjct: 882 DRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPG 941
Query: 562 TVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIR 621
TV+ + A+D D G V Y ++ G + G F +D +TG + + LDFE Y L +
Sbjct: 942 TVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLW 1000
Query: 622 AQDAGRPPLSNNTGLASIQVVDIND--HIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
A D GRP + V+D+N+ H P F S Q V EN+P G VI + A D D
Sbjct: 1001 ASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDD 1060
Query: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSAS 739
G + L+Y L F IN TG + PLDRE +Y+ V A D GS PLS+
Sbjct: 1061 SGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSV 1120
Query: 740 ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANS--AISYQITGGN 797
V + V D NDN P+ + ++ + EDA VGTSV+ + A D D++S +++ IT GN
Sbjct: 1121 TEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGN 1180
Query: 798 TRNRFAISTQGGVGLVTLALPLDYKQERYFKL-VLTASDRALHDHCYVHINITDANTHRP 856
F I G+ L + K E ++ VL + +L V + I D N + P
Sbjct: 1181 YMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPP 1240
Query: 857 VFQSAHYSVSVNED-RPMG-STIVVISASDDDVGENARITYLLEDNLPQ-FRIDADSGAI 913
+F ++V + E P+ + + ASD D G N R+TY +ED+ + F ID +G +
Sbjct: 1241 IFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVV 1300
Query: 914 TLQAPLDYEDQVTYTLAITARDNGIPQKADTT--YVEVMVNDVNDNAP-QFVASHYTGLV 970
+ + + L I A D+G P + + ++E + + P F ++Y+ V
Sbjct: 1301 SSSSTFTAGEY--NILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTV 1358
Query: 971 SEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAV 1030
E P V IS R G + G D D DF IE T+G + R LD
Sbjct: 1359 METDPVNHMVGVISVEGRP----GLFWFNISGG-DKDMDFDIEKTTGSIVIARPLDTRRR 1413
Query: 1031 SVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQIT 1090
S Y LT D G + T V I M+ ++N + P F +EVRV ++++ G + ++
Sbjct: 1414 SNYNLTVEVTD-GSRTIATQVHI-FMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQ 1471
Query: 1091 AVDPDEGPNAHIMYQIVEGNIP---ELFQMDIFSGELTALIDLDY---EARQEYVIVVQA 1144
A+D D+G + ++Y I P LFQ+D SG L + LD ++ ++V+
Sbjct: 1472 AIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD 1529
Query: 1145 TSAPLVSR---ATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGI-IGRIPAYDP 1200
P+ T+HV D N + P +Y ++ DT G + ++ A D
Sbjct: 1530 QEIPIKRNFVWVTIHVE--DGNLHPPRFTQL-----HYEASVPDTIAPGTELLQVRAMDA 1582
Query: 1201 D--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
D V+ + YS +GN +N G + L++KLD ++ V D
Sbjct: 1583 DRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAED 1634
Score = 333 bits (853), Expect = 2e-90
Identities = 273/950 (28%), Positives = 433/950 (45%), Gaps = 47/950 (4%)
Query: 322 HPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQ 381
+P F Y+ VPEN T +L A+ P E RL+Y+ ++ L LF+ D +
Sbjct: 2168 NPLFQSPYYKVRVPENITLYTPILHTQARSP---EGLRLIYN---IVEEEPLMLFTTDFK 2221
Query: 382 SGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
+G++ LD ES +H V A D S T V V V D ND+ P F Q Y +
Sbjct: 2222 TGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFSQLVYTTS 2280
Query: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
+ E + P++QL A+D D+ N ++ Y+ V + + F+I+ +G +ST +
Sbjct: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIV---EDGSDVSKFFQINGSTGEMSTVQEL 2337
Query: 502 DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561
D E + + + V A D+G P + V + V D NDN P+F + +Y A V E
Sbjct: 2338 DYEAQQHFHVKVRAMDKGDP--PLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCG 2395
Query: 562 TVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIR 621
+VL+V A D D + Y I+SGN HF I+S +G I + + Y LR+
Sbjct: 2396 HLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVG 2455
Query: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
A D + T I + N + P F ++ + ENA +G VI + A+D D G
Sbjct: 2456 ASDG----VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSG 2511
Query: 682 ENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVE--ARDHGSPPLSAS 739
++Y++ F IN G ++ LDRE+ ++ ARD G A
Sbjct: 2512 PYGTIDYTIINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDGGG--RVAF 2568
Query: 740 ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGN 797
+V + + D NDN P+F EY + + + + + V+ V A D D N+ ++Y + +
Sbjct: 2569 CTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPED 2628
Query: 798 -TRNRFAISTQGGVGLVTLAL-PLDYKQERYFKLVLTASDRALHDHCYVHINITDANTHR 855
++ I+ GV V +L L+ + +F + V + +
Sbjct: 2629 LVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSL 2688
Query: 856 PVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ------FRIDAD 909
P F Y+ S ED P GS I ++ A ++ I L+ P+ F +D D
Sbjct: 2689 PKFSEPLYTFSAPEDLPEGSEIGIVKAV---AAQDPVIYSLVRGTTPESNKDGVFSLDPD 2745
Query: 910 SGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGL 969
+G I ++ P+D+E Y + + A V + V DVNDN P F A Y +
Sbjct: 2746 TGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAV 2805
Query: 970 VSEDAPPFTSVLQISATDRDAHANGRVQY--TFQNGEDGDGDFTIEPTSGIVRTVRRLDR 1027
++E+ P TSV+Q++A D+D +G+V Y + G + F I+ SG + T++ LD
Sbjct: 2806 LTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDC 2865
Query: 1028 EAVSVYELTAYAVDRG-VPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
E Y A D G L + +QV + D NDNAP F +EE+ V ENS G +V
Sbjct: 2866 ETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELV 2925
Query: 1087 AQITAVDPD-EGPNAHIMYQIVEGNIPELFQMDIFSGE--LTALIDLDYEARQEYVIVVQ 1143
A + +D D N + I EG+ F + E +++ LD E +Y++ V
Sbjct: 2926 ATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVT 2985
Query: 1144 ATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPA--YDPD 1201
A+ + TV + ++D NDNSP + Q+L+ V D FP I ++ A D D
Sbjct: 2986 ASDGKFQASVTVEIFVLDVNDNSPQCS--QLLYTGKV--HEDVFPGHFILKVSATDLDTD 3041
Query: 1202 VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG 1251
+ + YS G ++ +GEL LD R V +++ TDG
Sbjct: 3042 TNAQITYSL-HGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDG 3090
Score = 323 bits (828), Expect = 2e-87
Identities = 261/956 (27%), Positives = 438/956 (45%), Gaps = 66/956 (6%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P+F Q +Y+ VP+ A GT +L+V A D D G + YSL + S F+I+
Sbjct: 1553 PRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSL---LKGNSEGFFNINALL 1609
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
G+I A LD+ + H L V A+D GSP+ V + V + +P+F +++Y +
Sbjct: 1610 GIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEI 1669
Query: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
E++ G PIL + A +P R F ++ SGLIST ++D
Sbjct: 1670 PESIPVGSPILLVSAM---SPSEVTYELR-------EGNKDGVFSMNSYSGLISTQKKLD 1719
Query: 503 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
E + SY+L + +G V V + ++DENDNAP F + +V Q+ E ++
Sbjct: 1720 HEKISSYQLKI----RGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYS 1775
Query: 563 VVLR-------VTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE 615
+++ + A+D DK+AN L+ Y I+ + F ID G + +V+ +D+E+
Sbjct: 1776 MIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPS 1835
Query: 616 YALRIRAQDAGRPPL-SNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQ 674
+ + D G P L + I V D+ND P F ++V+++ G ++ ++
Sbjct: 1836 FQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVR 1895
Query: 675 AVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEAR--DHG 732
A D E++ + YS+ D I+ TG +SV P F G+ +
Sbjct: 1896 ASD----EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPA--------FLGLSRKLTIRA 1943
Query: 733 SPPL-SASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISY 791
S L +A V +++ V D +F Y + E+ ++V + A N +SY
Sbjct: 1944 SDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSY 2003
Query: 792 QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHC---YVHINI 848
+ G + F + GV L T + D +Q+ +L + D V ++I
Sbjct: 2004 FLLNGT--DMFHMVQSAGV-LQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSI 2060
Query: 849 TDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDA 908
D N + P F+ Y + + G + +SA+D+D+G N +TY ++ FRID
Sbjct: 2061 EDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRIDP 2120
Query: 909 DSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTG 968
G I+L+ P DY+ Y L + ARD G P EV+V N + P F + +Y
Sbjct: 2121 YLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEE--EVLVTVRNKSNPLFQSPYYKV 2178
Query: 969 LVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDRE 1028
V E+ +T +L A + R+ Y E+ FT + +G++ LD E
Sbjct: 2179 RVPENITLYTPILHTQARSPEGL---RLIYNIVE-EEPLMLFTTDFKTGVLTVTGPLDYE 2234
Query: 1029 AVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQ 1088
+ + + T A D + + +++V+V+DVNDN P F + + E + V Q
Sbjct: 2235 SKTKHVFTVRATDTALGSF-SEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQ 2293
Query: 1089 ITAVDPDEGPNAHIMYQIVE--GNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT- 1145
+ A D D G N + YQIVE ++ + FQ++ +GE++ + +LDYEA+Q + + V+A
Sbjct: 2294 LLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD 2353
Query: 1146 --SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDV 1202
PL V V + D NDN P Q Y +N S+ G ++ ++ A DPD
Sbjct: 2354 KGDPPLTGETLVVVNVSDINDNPPEFRQPQ-----YEANVSELATCGHLVLKVQAIDPDS 2408
Query: 1203 SD--HLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVT 1256
D L Y GN+ + +N +SG + + + ++ V +DG+ T
Sbjct: 2409 RDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRAT 2464
Score = 310 bits (794), Expect = 2e-83
Identities = 275/989 (27%), Positives = 444/989 (44%), Gaps = 80/989 (8%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F + Y +PE+ G+ +L V A P + Y L +FS++ S
Sbjct: 1658 PIFSKSEYFVEIPESIPVGSPILLVSAMSPS-----EVTYELR---EGNKDGVFSMNSYS 1709
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATT--MVAVTVADRNDHSPVFEQAQYRE 440
GLI T LD E + + L++ GS A T MV V + D ND++P+F +
Sbjct: 1710 GLISTQKKLDHEKISSYQLKI----RGSNMAGAFTDVMVVVDIIDENDNAPMF----LKS 1761
Query: 441 TLRENVEEGYPILQL-----------RATDGDAPPNANLRYRFVGPPAARAAAAAAFEID 489
T + E P+ + A+D D N+ L Y+ + P A + F+ID
Sbjct: 1762 TFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKF-----FKID 1816
Query: 490 PRSGLISTSGRVDREHMESYELVVEASDQGQEP--GPRSATVRVHITVLDENDNAPQFSE 547
P G ++ +D E M S++ V DQG PR A V +H+ D ND+ P+FSE
Sbjct: 1817 PSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVR--DVNDSPPRFSE 1874
Query: 548 KRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAP 607
+ Y + + P +L V A+D D + N Y+I +GN+ I +TG I V+ P
Sbjct: 1875 QIYEVAIVGPIHPGMELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNP 1930
Query: 608 LDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLG 667
R+ L IRA D L +T L I + + D F + +V EN
Sbjct: 1931 AFLGLSRK--LTIRASDG----LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDR 1984
Query: 668 HSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVE 727
+++ I +H + + L G D ++ SA + DRE + + VE
Sbjct: 1985 KALV-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE 2041
Query: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--A 785
RD+ +P A V V++ DVNDN P+F Y+ + + G + V+A D D
Sbjct: 2042 VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGT 2101
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHD-HCYV 844
N A++Y+ T R +G ++L P DY+ + L + A D
Sbjct: 2102 NGAVTYEFAEDYTYFRI----DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEE 2157
Query: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL--EDNLP 902
+ +T N P+FQS +Y V V E+ + + I+ A E R+ Y + E+ L
Sbjct: 2158 EVLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARSP---EGLRLIYNIVEEEPLM 2214
Query: 903 QFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFV 962
F D +G +T+ PLDYE + + + A D + ++ T VEV+V DVNDN P F
Sbjct: 2215 LFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFS 2273
Query: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTF-QNGEDGDGDFTIEPTSGIVRT 1021
YT +SE P T V+Q+ A+D+D+ N V Y ++G D F I ++G + T
Sbjct: 2274 QLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMST 2333
Query: 1022 VRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSI 1081
V+ LD EA + + A+D+G PPL + V V D+NDN P F ++E V E +
Sbjct: 2334 VQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELAT 2393
Query: 1082 VGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIV 1141
G +V ++ A+DPD + + Y I+ GN F ++ SG ++ Y +
Sbjct: 2394 CGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLR 2453
Query: 1142 VQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201
V A+ + V++ + N SP Q L+ ++ + I + A D D
Sbjct: 2454 VGASDGVFRATVPVYINTTNANKYSPEFQ--QHLYEAELAENAMVGTKVI--DLLAIDKD 2509
Query: 1202 VSDHLFYSFERGNEL--QLLVVNQTSGELRLSRKLD--NNRPLVASMLVTVTDGLHSVTA 1257
+ + N+L + +N +G++ +KLD N+ V ++ V DG V A
Sbjct: 2510 SGPYGTIDYTIINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDGGGRV-A 2567
Query: 1258 QCVLRVVIITE-----ELLANSLTVRLEN 1281
C +++++ E + A+ TV +++
Sbjct: 2568 FCTVKIILTDENDNPPQFKASEYTVSIQS 2596
Score = 293 bits (750), Expect = 2e-78
Identities = 243/835 (29%), Positives = 391/835 (46%), Gaps = 61/835 (7%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + PQ Q + + E+ GT+VL++ A DPD+ G+L +++ + + F
Sbjct: 1130 ANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNIT---SGNYMGFFM 1186
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
I P +GL+ TA LDRE+ + H L VT D+G P L +T+ V V + D ND+ P+F
Sbjct: 1187 IHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKL 1246
Query: 438 YRETLRENVE--EGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
+ L E + P+ +L A+D D N + Y + + AF ID +G++
Sbjct: 1247 FNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTY------SIEDSDEEAFSIDLVTGVV 1300
Query: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVL--DENDNAP-QFSEKRYVA 552
S+S E L ++A+D GQ P SA+VR+HI + + P F E Y
Sbjct: 1301 SSSSTFTAG--EYNILTIKATDSGQP--PLSASVRLHIEWIPWPRPSSIPLAFDETYYSF 1356
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E + +V ++ R GL +NI G+ F I+ TG I + PLD
Sbjct: 1357 TVMETDPVNHMVGVISVEGRP----GLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRR 1412
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Y L + D R + T + + +IN H P F+ T ++V V ++ G ++
Sbjct: 1413 RSNYNLTVEVTDGSR---TIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLR 1469
Query: 673 IQAVDADHGENARLEYSLTG---VAPDTPFVINSATGWVSVSGPLDRES-VEHYFFGVEA 728
+QA+D D G++ L Y++ G + F ++ ++G + G LD S + V
Sbjct: 1470 VQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMV 1527
Query: 729 RDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--AN 786
RD P VT+ V D N + P FT Y + + A GT ++ V A+D D N
Sbjct: 1528 RDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVN 1587
Query: 787 SAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCY 843
+ + Y + GN+ F I+ +G++TLA LD L + A D+ HD
Sbjct: 1588 AEVHYSLLKGNSEGFFNINAL--LGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLAT 1645
Query: 844 VHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ 903
V I++ ++ P+F + Y V + E P+GS I+++SA + +TY L +
Sbjct: 1646 VIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKD 1700
Query: 904 --FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF 961
F +++ SG I+ Q LD+E +Y L I R + + V V + D NDNAP F
Sbjct: 1701 GVFSMNSYSGLISTQKKLDHEKISSYQLKI--RGSNMAGAFTDVMVVVDIIDENDNAPMF 1758
Query: 962 VASHYTGLVSEDAPPFTSVLQ-------ISATDRDAHANGRVQYTFQNGEDGDGDFTIEP 1014
+ S + G +SE AP ++ ++ I A+D D AN + Y E F I+P
Sbjct: 1759 LKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPE-ALKFFKIDP 1817
Query: 1015 TSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVM--VQDVNDNAPVFPAEEF 1072
+ G + V +D E++ ++ Y D+G P L P QV+ V+DVND+ P F + +
Sbjct: 1818 SMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIY 1877
Query: 1073 EVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL 1127
EV + G + + A D D + + Y I GN E + +G ++ L
Sbjct: 1878 EVAIVGPIHPGMELLMVRASDED----SEVNYSIKTGNADEAVTIHPVTGSISVL 1928
Score = 281 bits (720), Expect = 6e-75
Identities = 261/997 (26%), Positives = 425/997 (42%), Gaps = 130/997 (13%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F +Y+ + E+ + + +V A D D G+ Y+ N+RS E+F+I P S
Sbjct: 146 PLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF----NTRS-EMFAIHPTS 200
Query: 383 GLIRTAAALDRESMERHYLRVTAQD-------------------HGSPRL---SATTMVA 420
G++ A L+ +H L+V A D H P L A V
Sbjct: 201 GVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV 260
Query: 421 VTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARA 480
VT D ND + Y L + G + + GD P
Sbjct: 261 VTPPDSNDGT------TYATVLVDANSSGAEVESVEVVGGD--------------PGKHF 300
Query: 481 AAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEND 540
A ++ L+S E++ + L ++A G P S H+
Sbjct: 301 KAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQAR-SGSGPYFYSQIRGFHLP--PSKL 357
Query: 541 NAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTG 600
++ +F + Y Q+ E P + V+ V T A + Y + + F +++ TG
Sbjct: 358 SSLKFEKAVYRVQLSEFSPPGSRVVMVRVT----PAFPNLQYVLKPSSENVGFKLNARTG 413
Query: 601 EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSV 660
I +DF Y L IR + + I +VD N+H P+F + + ++
Sbjct: 414 LITTTKLMDFHDRAHYQLHIRTSP------GQASTVVVIDIVDCNNHAPLFNRSSYDGTL 467
Query: 661 LENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVE 720
EN P G SV+ + A D DHGEN + YS+ G PF I+ G +S S P+D E ++
Sbjct: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAG-PKALPFSIDPYLGIISTSKPMDYELMK 526
Query: 721 H-YFFGVEARDHGSP-PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSV 778
Y F V A D GSP S+ + + ++NDN+P F + +D VG S++++
Sbjct: 527 RIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTM 586
Query: 779 TAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALP---LDYKQERYFKLVLTASD 835
+A+D D + Y+I GN F ++ GV ++L P L Q + L +TASD
Sbjct: 587 SAIDVDELQNLKYEIVSGNELEYFDLNHFSGV--ISLKRPFINLTAGQPTSYSLKITASD 644
Query: 836 -------------------------------------RALH----------DHCYVHINI 848
LH D + ++
Sbjct: 645 GKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
Query: 849 TDANTHRPVFQSAHY--SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
N + P F+ H+ S+ V E P+ + + ++A+D D G N ++ Y++ D + F
Sbjct: 705 YQINHYTPQFED-HFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCF 763
Query: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVAS 964
I+ ++G +T+ APLDYE Y L +T D G PQK+ + V V D NDNAP+F
Sbjct: 764 DIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPG 823
Query: 965 HYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRR 1024
Y +SED T++ +++ D D+ NGRV+YT + + F++ P +G +
Sbjct: 824 GYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTE---KFSLHPLTGELVVTGH 880
Query: 1025 LDREAVSVYELTAYAVDRGVP--PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
LDRE+ Y L A D+ L + + + ++DVNDN+P E ++V E+
Sbjct: 881 LDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPP 940
Query: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVV 1142
G+V+ + A DPD GP + Y +++G F++D+ +G L +LD+E R Y + +
Sbjct: 941 GTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSL 999
Query: 1143 QATSA--PLVSRATVHVRLV--DQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAY 1198
A+ PL R HV ++ D N+N + + V S + I+
Sbjct: 1000 WASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDD 1059
Query: 1199 DPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLD 1235
D + L Y G L +NQ +G ++ LD
Sbjct: 1060 DSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLD 1096
Score = 242 bits (617), Expect = 5e-63
Identities = 246/966 (25%), Positives = 418/966 (43%), Gaps = 125/966 (12%)
Query: 389 AALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEE 448
A L+RE + + L + A + + L A T V V + D+ND P+F YR T+ E++
Sbjct: 105 ALLNREVRDSYTLIIQATEK-TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPL 163
Query: 449 GYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMES 508
PI ++ ATD D NA Y F + F I P SG+++ +G+++
Sbjct: 164 KSPICKVTATDADLGQNAEFYYAF-------NTRSEMFAIHPTSGVVTVAGKLNVTWRGK 216
Query: 509 YELVVEASD------QGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV------RE 556
+EL V A D +G G +A V VH+ P + +A V
Sbjct: 217 HELQVLAVDRMRKISEGNGFGSLAALV-VHVE--------PALRKPPAIASVVVTPPDSN 267
Query: 557 DVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHF-AIDSL--TGEIQVVAPLDF--- 610
D + VL D + + ++ G+ HF AI S + E +V+ D
Sbjct: 268 DGTTYATVL----VDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWM 323
Query: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
E + L ++A+ P + + + F ++V + E +P G V
Sbjct: 324 EYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRV 381
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
+ ++ A L+Y L + + F +N+ TG ++ + +D HY +
Sbjct: 382 VMVRVTPAF----PNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIR--- 434
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSA 788
+ P AS V + ++D N++ P F Y L+E+ GTSV++VTA DRD N
Sbjct: 435 --TSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGY 492
Query: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK-QERYFKLVLTASDRAL----HDHCY 843
++Y I G S +G+++ + P+DY+ +R + + ASD
Sbjct: 493 VTYSIAGPKA---LPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVS 549
Query: 844 VHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ 903
+ + + + N ++P+F+ + + S+ +D P+G +I+ +SA D D +N + + + L
Sbjct: 550 IFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEY 609
Query: 904 FRIDADSGAITLQAP---LDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAP- 959
F ++ SG I+L+ P L +Y+L ITA D G + TT +V D + P
Sbjct: 610 FDLNHFSGVISLKRPFINLTAGQPTSYSLKITASD-GKNYASPTTLNITVVKDPHFEVPV 668
Query: 960 ---------QFVAS--HYTGL----------------------------------VSEDA 974
QF + H+ GL V E
Sbjct: 669 TCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESV 728
Query: 975 PPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYE 1034
P T + +++ATD DA NG++ Y +G + +G F IE +G++ LD EA + Y
Sbjct: 729 PINTPLARLAATDPDAGFNGKLVYVIADGNE-EGCFDIELETGLLTVAAPLDYEATNFYI 787
Query: 1035 LTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDP 1094
L D G P + + V V+D NDNAP FP +++ + E++ VG+ +A++T D
Sbjct: 788 LNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDA 847
Query: 1095 DEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAP-----L 1149
D N + Y ++ E F + +GEL LD E+ Y++ V+A P L
Sbjct: 848 DSEDNGRVRYTLLSPT--EKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQL 905
Query: 1150 VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDV--SDHLF 1207
S + + L D NDNSP I +N + D P ++ + A DPD+ + +
Sbjct: 906 FSVTDLIITLEDVNDNSPQC----ITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVR 961
Query: 1208 YSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVIIT 1267
Y G V+ +G L L R+LD R ++ + +DG + + + V +I
Sbjct: 962 YVLMDGAH-GTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIV 1020
Query: 1268 EELLAN 1273
++ N
Sbjct: 1021 LDVNEN 1026
Score = 172 bits (436), Expect = 5e-42
Identities = 203/846 (23%), Positives = 353/846 (41%), Gaps = 98/846 (11%)
Query: 462 APPNANLRYRFVGPPAARAAAAAAFEIDPRSGL-----ISTSGRVDREHMESYELVVEAS 516
A P +RYR + A + + L S + ++RE +SY L+++A+
Sbjct: 63 AEPQWAVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQAT 122
Query: 517 DQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDA 576
++ E A RV + +LD+ND P FS Y + ED+ + + +VTATD D
Sbjct: 123 EKTLE---LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQ 179
Query: 577 NGLVHYNIISGNSRGH-FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTG 635
N +Y + N+R FAI +G + V L+ ++ L++ A D R +S G
Sbjct: 180 NAEFYY---AFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMR-KISEGNG 235
Query: 636 LASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAP 695
S+ + ++ P P SV+ P + V D + S+ V
Sbjct: 236 FGSLAALVVHVE-PALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGG 294
Query: 696 D--------TPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVL 747
D + ++ VSV E + + ++AR GS P S +
Sbjct: 295 DPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARS-GSGPYFYSQIRGFHLP 353
Query: 748 DVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQ 807
+ +F Y ++L+E + G+ VV V N + Y + + F ++ +
Sbjct: 354 PSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN--LQYVLKPSSENVGFKLNAR 411
Query: 808 GGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSV 867
GL+T +D+ +++L + S V I+I D N H P+F + Y ++
Sbjct: 412 --TGLITTTKLMDFHDRAHYQLHIRTSPG--QASTVVVIDIVDCNNHAPLFNRSSYDGTL 467
Query: 868 NEDRPMGSTIVVISASDDDVGENARITYLL--EDNLPQFRIDADSGAITLQAPLDYE-DQ 924
+E+ P G++++ ++A+D D GEN +TY + LP F ID G I+ P+DYE +
Sbjct: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP-FSIDPYLGIISTSKPMDYELMK 526
Query: 925 VTYTLAITARDNGIP-QKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQI 983
YT + A D G P ++ + + + ++NDN P F + TG + +D P S++ +
Sbjct: 527 RIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTM 586
Query: 984 SATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR---RLDREAVSVYELTAYAV 1040
SA D D N ++Y +G + + F + SG++ R L + Y L A
Sbjct: 587 SAIDVDELQN--LKYEIVSGNELE-YFDLNHFSGVISLKRPFINLTAGQPTSYSLKITAS 643
Query: 1041 DRGVPPLRTPVSIQVMVQDVNDNAPV-------------------------FPAEEF--- 1072
D T ++I V V+D + PV EEF
Sbjct: 644 DGKNYASPTTLNITV-VKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSL 702
Query: 1073 ------------------EVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPEL 1114
+ V E+ + + +A++ A DPD G N ++Y I +GN
Sbjct: 703 STYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGC 762
Query: 1115 FQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSRAT---VHVRLVDQNDNSPVL-- 1169
F +++ +G LT LDYEA Y++ V +++ + V + D NDN+P
Sbjct: 763 FDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPP 822
Query: 1170 NNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELR 1229
+Q+ + DT I + D D D+ + + + ++ +GEL
Sbjct: 823 GGYQLTIS------EDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELV 876
Query: 1230 LSRKLD 1235
++ LD
Sbjct: 877 VTGHLD 882
Score = 159 bits (403), Expect = 3e-38
Identities = 212/809 (26%), Positives = 331/809 (40%), Gaps = 138/809 (17%)
Query: 539 NDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRD-KDANGLVHYNIISGNSR------- 590
+ +A F+ Y A + E+ P T V + V Y IISG+
Sbjct: 27 SSSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEE 86
Query: 591 ---GHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDH 647
G+F + + A L+ E Y L I+A + L T + + ++D ND
Sbjct: 87 YVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE-LEALTRVV-VHILDQNDL 144
Query: 648 IPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGW 707
P+F ++V++ E+ PL + + A DAD G+NA Y+ F I+ +G
Sbjct: 145 KPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFN--TRSEMFAIHPTSGV 202
Query: 708 VSVSGPLD-----------------RESVEHYFFGVEAR--DHGSPPLS---ASASVTVT 745
V+V+G L+ R+ E FG A H P L A ASV VT
Sbjct: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVT 262
Query: 746 VLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA----ISYQITGGNTRNR 801
D ND GT+ +V DANS+ S ++ GG+
Sbjct: 263 PPDSND--------------------GTTYATVLV---DANSSGAEVESVEVVGGDPGKH 299
Query: 802 F-AISTQGGVGLVTLALPLDYKQERY---FKLVLTASDRALHDHCYVHI---NITDANTH 854
F AI + +L D Y F L L A + + Y I ++ +
Sbjct: 300 FKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGS-GPYFYSQIRGFHLPPSKLS 358
Query: 855 RPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGA 912
F+ A Y V ++E P GS +V++ + + Y+L+ + F+++A +G
Sbjct: 359 SLKFEKAVYRVQLSEFSPPGSRVVMVRVTP----AFPNLQYVLKPSSENVGFKLNARTGL 414
Query: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972
IT +D+ D+ Y L I P +A T V + + D N++AP F S Y G + E
Sbjct: 415 ITTTKLMDFHDRAHYQLHIRTS----PGQASTVVV-IDIVDCNNHAPLFNRSSYDGTLDE 469
Query: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVS- 1031
+ PP TSVL ++ATDRD NG V Y+ + F+I+P GI+ T + +D E +
Sbjct: 470 NIPPGTSVLAVTATDRDHGENGYVTYSIAGPK--ALPFSIDPYLGIISTSKPMDYELMKR 527
Query: 1032 VYELTAYAVDRGVPPLR-TPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQIT 1090
+Y A D G P R VSI + ++++NDN P+F ++++ VG + ++
Sbjct: 528 IYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMS 587
Query: 1091 AVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELT---ALIDLDYEARQEYVIVVQAT-- 1145
A+D DE N + Y+IV GN E F ++ FSG ++ I+L Y + + A+
Sbjct: 588 AIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
Query: 1146 ---SAPLVSRATV----HVRLVDQNDNSPVLNNF------------------------QI 1174
++P TV H + D + VL F
Sbjct: 646 KNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTY 705
Query: 1175 LFNNYVSNRSDTFPSGI-----------IGRIPAYDPDV--SDHLFYSFERGNELQLLVV 1221
N+Y D FP I + R+ A DPD + L Y GNE +
Sbjct: 706 QINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDI 765
Query: 1222 NQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
+G L ++ LD + VTV D
Sbjct: 766 ELETGLLTVAAPLDYEATNFYILNVTVYD 794
Score = 77.4 bits (189), Expect = 2e-13
Identities = 49/145 (33%), Positives = 69/145 (47%), Gaps = 14/145 (9%)
Query: 1432 CETELDLCYSNPCRNGGACARREG-GYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTC 1490
C D C N C NGG C+ G GY C C P+F+G+ CE E C C GGTC
Sbjct: 3944 CCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGRE--NCTFAPCLEGGTC 4001
Query: 1491 TDAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFR-------GLRQRFHLTLSLSF 1543
+P G C CP + G RCE+ AR ++ G ++ +T++++F
Sbjct: 4002 ILSPKGA-SCNCP--HPYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAF 4058
Query: 1544 ATVQQSGLLFYNGRLNEKHDFLALE 1568
+ GLLFY R + H +A+E
Sbjct: 4059 IIISTVGLLFYCRRC-KSHKPVAME 4082
Score = 59.3 bits (142), Expect = 6e-08
Identities = 28/68 (41%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
Query: 1417 AGLRCRCPPGFTGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEA 1476
AG C+CPP F+G CE + C PC GG C G +C C +TG+ CE+ EA
Sbjct: 3968 AGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEM--EA 4025
Query: 1477 GRCVPGVC 1484
C G C
Sbjct: 4026 RGCSEGHC 4033
Score = 46.2 bits (108), Expect = 5e-04
Identities = 53/199 (26%), Positives = 77/199 (38%), Gaps = 32/199 (16%)
Query: 1837 LLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQ-L 1895
L Q V+D WH + +E E R LMV S+ ++ V +GL+ ++ L
Sbjct: 3841 LSSQRHVNDHEWHSILVE--EMDASIR----LMVD---SMGNTSLVVPENCRGLRPERHL 3891
Query: 1896 HVGGLPP-GSAEEAPQGLVGCIQGVWLGSTPSGSPALLPPSHRVNA-------EPGCVVT 1947
+GGL S+ QG GC+ V + LL P V C+ +
Sbjct: 3892 LLGGLILLHSSSNVSQGFEGCLDAVVVNEEALD---LLAPGKTVAGLLETQALTQCCLHS 3948
Query: 1948 NACASGPCPPHADCRDLWQT---FSCTCQPGYYGPGCVDA---CLLNPCQNQGSCRHLPG 2001
+ C+ C C W + C C P + G C C PC G+C
Sbjct: 3949 DYCSQNTCLNGGKCS--WTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCIL--- 4003
Query: 2002 APHGYTCDCVGGYFGHHCE 2020
+P G +C+C Y G CE
Sbjct: 4004 SPKGASCNCPHPYTGDRCE 4022
Score = 44.7 bits (104), Expect = 0.002
Identities = 63/259 (24%), Positives = 104/259 (40%), Gaps = 58/259 (22%)
Query: 1513 CEVAARSFPPSSFVMFRGLRQR-FHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVA 1571
C A F S+V +R R +H+ L T+Q +L + ++L+L +
Sbjct: 3771 CNGTATRFSGQSYVRYRAPAARNWHIHFYLK--TLQPQAILLFTNETAS----VSLKLAS 3824
Query: 1572 GQVRLTYST--GESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAV 1629
G +L Y G + S ++D +WH++
Sbjct: 3825 GVPQLEYHCLGGFYGNLSSQR---HVNDHEWHSI-------------------------- 3855
Query: 1630 LSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENFPVSHKD 1689
V++ D ++ L + +GN S V + + L LLLGG+ L + VS +
Sbjct: 3856 -LVEEMDASIRLMVDS-MGNTSL----VVPENCRGLRPERHLLLGGLILLHSSSNVS-QG 3908
Query: 1690 FIGCMRDLHIDGRRVDMAAFVANNGTMAGC-------QAKLH--FCDSGPCKNSGFCSER 1740
F GC+ + ++ +D+ +A T+AG Q LH +C C N G CS
Sbjct: 3909 FEGCLDAVVVNEEALDL---LAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGGKCSWT 3965
Query: 1741 WGS-FSCDCPVGFGGKDCQ 1758
G+ + C CP F GK C+
Sbjct: 3966 HGAGYVCKCPPQFSGKHCE 3984
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 363 bits (931), Expect = 2e-99
Identities = 271/864 (31%), Positives = 419/864 (48%), Gaps = 38/864 (4%)
Query: 390 ALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEG 449
ALDRE H + V D GSP +AT V V+V D ND+ P F Q + L V EG
Sbjct: 796 ALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEG 855
Query: 450 YPILQLRAT----DGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREH 505
P+ L T D D NA + Y + ++ F+ID +G I T+ + ++
Sbjct: 856 QPVNMLVTTVFAKDPDEGNNAEVTYS-----VSSEDSSDHFKIDANNGEIRTTTILSYDY 910
Query: 506 MESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVL 565
SY + V A+DQG P A V + + L + + + + + E+++P ++
Sbjct: 911 RPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLI--IPENLKPTKIMS 968
Query: 566 RVTATDR-DKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQD 624
+ ++D + NG +H++I++ + GHF IDS TG++ + LD+E Y R+ D
Sbjct: 969 LIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTD 1028
Query: 625 AGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG-EN 683
+ ++T SI V D NDH P F +SV EN P+G V A D D N
Sbjct: 1029 HSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLN 1088
Query: 684 ARLEYSLTGVAPDT-PFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG---SPPLSAS 739
+R++Y + P T PF+I+ + G + LDRES+ V A D + S
Sbjct: 1089 SRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRS 1148
Query: 740 ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGN 797
+ + +LDVND+ P F + + + ED VG+ V +TA D D N ++Y I GN
Sbjct: 1149 LTAQIVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGN 1207
Query: 798 TRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD---RALHDHCYVHINITDANTH 854
F + GL+T PLDY+ + L + A D AL + + + D N
Sbjct: 1208 ENMTFMLDESS--GLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDE 1265
Query: 855 RPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED--NLPQFRIDADSGA 912
PVF+ Y SV E++ G + + A D D G N+++ + + + F I++D+G
Sbjct: 1266 APVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGE 1325
Query: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972
+ LD E Q +TL + RD G P + TT + V D ND+AP+F+ S Y V E
Sbjct: 1326 VVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLE 1385
Query: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSV 1032
+ P V + A+D DA N V+Y +G + D FTI SG + T R LDRE +S
Sbjct: 1386 NQEP-EVVYTVLASDMDAGNNRAVEYHIIDG-NTDECFTINEMSGELSTTRALDREQISN 1443
Query: 1033 YELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAV 1092
+ L D G PP + + +QV V D ND++P FP ++ V+E++ VG+VV ++AV
Sbjct: 1444 FTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAV 1503
Query: 1093 DPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLV-S 1151
D DEG N Y + + F +D SG L LD EAR ++ A + S
Sbjct: 1504 DKDEGLNGQTEYFLTD-EASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGS 1562
Query: 1152 RAT---VHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFY 1208
R+T + V + D NDN PVL Q F+ ++S S T + +I R D + + +
Sbjct: 1563 RSTTVIIKVYVTDVNDNDPVLE--QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
Query: 1209 SFERGNELQLLVVNQTSGELRLSR 1232
SF + +++ +GE++ +
Sbjct: 1621 SF--AETQSMFSIDKYTGEIQFQQ 1642
Score = 362 bits (928), Expect = 4e-99
Identities = 284/949 (29%), Positives = 446/949 (46%), Gaps = 65/949 (6%)
Query: 319 ANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
AN H P FP YQ+ V E+ GT VL + A D D G G+ Y + + F+
Sbjct: 1471 ANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY----FLTDEASGAFT 1526
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQD---HGSPRLSATTMVAVTVADRNDHSPVFE 434
IDP SG ++T+ LDRE+ +H A+D GS S T ++ V V D ND+ PV E
Sbjct: 1527 IDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGS--RSTTVIIKVYVTDVNDNDPVLE 1584
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Q + L + +RA D D PN + + F A + F ID +G
Sbjct: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-------AETQSMFSIDKYTGE 1637
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
I E+ + L ++ +DQG P T + + ++ D FS Y V
Sbjct: 1638 IQFQQNPSSEYFPIW-LQLKVTDQGI---PARTTTGLLVIHMEGEDVKISFSHHLYKGLV 1693
Query: 555 REDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAP--LDFEA 612
E+ T ++ V A D + + Y+I SGN G ++ S +G++ V P LDFE
Sbjct: 1694 TENCEAGTSIVTVKAFAPDSIQDSM-KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV 1752
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
E L + A+ +G ++ + D ND+ P F + +Q SV E+ VI
Sbjct: 1753 RNEVQLIVLAESSGHRAYCK----VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQ 1808
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG 732
+ A D D G N +EYS+ + F I++ +G ++ LD E Y V+A D G
Sbjct: 1809 VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKG 1868
Query: 733 SPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQ 792
P LS + + V V D+NDN P F E + + ED+ G V V+ D D NSA +
Sbjct: 1869 MPRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNSAFIFS 1927
Query: 793 IT-GGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINITDA 851
N +FAI GV V L LD+++ ++L++ SD + + + + D
Sbjct: 1928 FAKESNPGTKFAIDQNTGV--VVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDV 1985
Query: 852 NTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSG 911
N + PVF Y V+V E P+G +++ +SA+D + EN I+Y + + +F ID +G
Sbjct: 1986 NDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKEFSIDPKNG 2043
Query: 912 AITLQAPLDYEDQVTYT-LAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLV 970
I +P+ D ++ T + A D G P T VE+ + D+N+ AP+F Y +
Sbjct: 2044 TIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSL 2103
Query: 971 SEDAPPFTSVLQISATDRD-AHANGRVQYTFQNGEDGDGDFTIE----------PTSGIV 1019
SEDA ++++ S D D N V+Y+ +G + +F +E G +
Sbjct: 2104 SEDALVGSTLVTFSNIDHDWTRENTYVEYSIISG-NSQNNFHVETKFFHSEYPYKQVGYL 2162
Query: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
+ LDREA + +EL A D G PPL + I + V DVNDN P F + + VKE+
Sbjct: 2163 VLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKES 2222
Query: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV 1139
+ +GS + ++A D D G +A I+Y I+ GN F ++ +G L + LDYE ++
Sbjct: 2223 TPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFT 2282
Query: 1140 IVVQATSAPL--VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFP-SGIIGRIP 1196
+ VQA+ A S A V V ++D ND++P Q +F+++ + P S I I
Sbjct: 2283 LTVQASDAEKKHFSFAVVFVSVLDDNDHAP-----QFMFSSFSCIVPENLPISSTICSIN 2337
Query: 1197 AYDPDVSDH----------LFYSFERGNELQLLVVNQTSGELRLSRKLD 1235
A D D + F + + L +++ +G++ + LD
Sbjct: 2338 ALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILD 2386
Score = 357 bits (916), Expect = 1e-97
Identities = 282/907 (31%), Positives = 442/907 (48%), Gaps = 38/907 (4%)
Query: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP-RLSATTMVAVTVADRNDHSPVFE 434
F ID +G + + LD E+ + RV DH LS+T +++ V D+NDHSP F+
Sbjct: 997 FEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQ 1056
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAP-PNANLRYRFVGPPAARAAAAAAFEIDPRSG 493
++ ENV G + A D D N+ ++Y + F I P G
Sbjct: 1057 DELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYI----ESHNPGTNPFLIHPSFG 1112
Query: 494 LISTSGRVDREHMESYELVVEASDQGQEPGPRSA-TVRVHITVLDENDNAPQFSEKRYVA 552
+ T R+DRE + + L V ASDQ R ++ I +LD ND+ P F A
Sbjct: 1113 TLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-A 1171
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V+EDV ++V +TA D D+ NG V Y+I+SGN F +D +G + PLD+E
Sbjct: 1172 HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEM 1231
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
+ ++ L + A D G P LS++ L ++ V+D+ND P+F ++ SV EN G V
Sbjct: 1232 KTQHILTVLALDDGTPALSSSQTL-TVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTR 1290
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG 732
++A+D D G N++L++ + A F INS TG V + LDRE E + V RD G
Sbjct: 1291 VEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGG 1350
Query: 733 SPPLSASASVTVTVLDVNDNRPEFTMKEYHLRL--NEDAAVGTSVVSVTAVDRDA--NSA 788
P LS++ ++ TV D ND+ PEF + Y + + N++ V V +V A D DA N A
Sbjct: 1351 FPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV---VYTVLASDMDAGNNRA 1407
Query: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVH 845
+ Y I GNT F I+ G T A LD +Q F LV+ SD ++
Sbjct: 1408 VEYHIIDGNTDECFTINEMSGELSTTRA--LDREQISNFTLVILCSDLGDPPRSSVIHLQ 1465
Query: 846 INITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLP-QF 904
+ + DAN H P F + +Y SV ED +G+ ++V+SA D D G N + Y L D F
Sbjct: 1466 VRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAF 1525
Query: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIP-QKADTTYVEVMVNDVNDNAPQFVA 963
ID SG + LD E + +T + ARD I ++ T ++V V DVNDN P
Sbjct: 1526 TIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQ 1585
Query: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR 1023
+ + +S ++P + + + A D D NG V ++F + F+I+ +G ++ +
Sbjct: 1586 NPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF---AETQSMFSIDKYTGEIQFQQ 1642
Query: 1024 RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVG 1083
E ++ L D+G+ P RT + V+ + D F ++ V EN G
Sbjct: 1643 NPSSEYFPIW-LQLKVTDQGI-PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAG 1700
Query: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALID--LDYEARQEYVIV 1141
+ + + A PD ++ + Y I GN + + SG+LT LD+E R E ++
Sbjct: 1701 TSIVTVKAFAPDSIQDS-MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLI 1759
Query: 1142 VQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201
V A S+ + V V + D+NDNSP Q ++ VS S + + +I ++ A D D
Sbjct: 1760 VLAESSGHRAYCKVAVLIQDENDNSPCFE--QSIYQASVS-ESQLYNAHVI-QVFATDLD 1815
Query: 1202 --VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD-GLHSVTAQ 1258
++ + YS GN+ + ++ SG + LD S++V TD G+ ++
Sbjct: 1816 SGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNT 1875
Query: 1259 CVLRVVI 1265
V++V +
Sbjct: 1876 TVIKVQV 1882
Score = 355 bits (912), Expect = 3e-97
Identities = 260/854 (30%), Positives = 425/854 (49%), Gaps = 37/854 (4%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P F Q+ Y+ V EN+ G V RV A D D+G +L + + M S ELF I+ +
Sbjct: 1267 PVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI---MPGASFELFEINSDT 1323
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
G + T LDRE E LRV +D G P LS+TT + TV D NDH+P F + Y +
Sbjct: 1324 GEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEV 1383
Query: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
EN +E + + A+D DA N + Y + F I+ SG +ST+ +D
Sbjct: 1384 LEN-QEPEVVYTVLASDMDAGNNRAVEYHIID-----GNTDECFTINEMSGELSTTRALD 1437
Query: 503 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
RE + ++ LV+ SD G PRS+ + + + VLD ND++P F Y + VRED T
Sbjct: 1438 REQISNFTLVILCSDLGDP--PRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGT 1495
Query: 563 VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRA 622
VVL ++A D+D+ NG Y ++ + G F ID ++G ++ LD EA ++ A
Sbjct: 1496 VVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVA 1554
Query: 623 QDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGE 682
+D + T + + V D+ND+ P+ PF V + +P + + ++A D D G
Sbjct: 1555 RDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGP 1614
Query: 683 NARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY--FFGVEARDHGSPPLSASA 740
N + +S + F I+ TG + S E++ + ++ D G P +
Sbjct: 1615 NGTVVFSF--AETQSMFSIDKYTGEIQFQ---QNPSSEYFPIWLQLKVTDQGI-PARTTT 1668
Query: 741 SVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA-NSAISYQITGGNTR 799
+ V ++ D + F+ Y + E+ GTS+V+V A D+ ++ Y I GN
Sbjct: 1669 GLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNED 1728
Query: 800 NRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQ 859
++ ++ G V LD++ +L++ A +C V + I D N + P F+
Sbjct: 1729 GVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFE 1788
Query: 860 SAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDNLPQ-FRIDADSGAITLQA 917
+ Y SV+E + + ++ + A+D D G N I Y +L N + F+IDA SG IT +A
Sbjct: 1789 QSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKA 1848
Query: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
LDYE +Y+L + A D G+P+ ++TT ++V V D+NDNAP F+ S ++ED+ P
Sbjct: 1849 ILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVE-ITEDSLPG 1907
Query: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
V +S D D N ++F + F I+ +G+V V+ LD E ++ YEL
Sbjct: 1908 VIVTHVSVHDVD--LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLI 1965
Query: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG 1097
D T ++ V V DVNDN PVF + ++V V E+ VG V ++A D +
Sbjct: 1966 QISD---SVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES- 2021
Query: 1098 PNAHIMYQIVEGNIPELFQMDIFSG---ELTALIDLDYEARQEYVIVVQATSAP-LVSRA 1153
N +I Y+I+ + + F +D +G ++ ++ LD + ++++ P L +
Sbjct: 2022 -NENISYRILSSS--KEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALT 2078
Query: 1154 TVHVRLVDQNDNSP 1167
V + + D N+ +P
Sbjct: 2079 LVEIGIEDMNNYAP 2092
Score = 330 bits (845), Expect = 2e-89
Identities = 273/930 (29%), Positives = 424/930 (45%), Gaps = 44/930 (4%)
Query: 320 NRHPQFPQY----NYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLEL 375
+ P FPQ V E + V V A+DPD G + YS+++ S +
Sbjct: 834 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS---EDSSDH 890
Query: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
F ID +G IRT L + + + V A D G P L +V + V + + Q
Sbjct: 891 FKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQ 950
Query: 436 AQYRETLRENVEEGYPILQLRATDG-DAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
+ EN++ + ++++D N L + V FEID +G
Sbjct: 951 NIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADD-----KDGHFEIDSSTGD 1005
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
+ S +D E Y V +D + S+TV + I V D+ND++P F ++ V V
Sbjct: 1006 LFLSKELDYETTSHYLFRVITTDHSKNLS-LSSTVFLSIDVEDQNDHSPSFQDELIVISV 1064
Query: 555 REDVRPHTVVLRVTATDRDKD-ANGLVHYNIISGN-SRGHFAIDSLTGEIQVVAPLDFEA 612
E+V T+V A D D N + Y I S N F I G + V+ LD E+
Sbjct: 1065 EENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES 1124
Query: 613 EREYALRIRAQDAGRPPLSN--NTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
L + A D + A I ++D+NDH P F+S P V E+ +G V
Sbjct: 1125 IPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLV 1183
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
HI A D D G N ++ YS+ + F+++ ++G ++ + PLD E + V A D
Sbjct: 1184 HHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALD 1243
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSA 788
G+P LS+S ++TVTVLDVND P F Y + E+ G V V A+DRD+ NS
Sbjct: 1244 DGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSK 1303
Query: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD---RALHDHCYVH 845
+ ++I G + F I++ G + T LD + + F L + D +L +
Sbjct: 1304 LQFEIMPGASFELFEINSDTGEVVTTTI--LDREIQEVFTLRVLVRDGGFPSLSSTTTIL 1361
Query: 846 INITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDNLPQ- 903
+ D N H P F + Y + V E++ + + ASD D G N + Y +++ N +
Sbjct: 1362 CTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDMDAGNNRAVEYHIIDGNTDEC 1420
Query: 904 FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVA 963
F I+ SG ++ LD E +TL I D G P ++ +++V V D ND++P F
Sbjct: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
Query: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR 1023
+Y V EDA T VL +SA D+D NG+ +Y ++ G FTI+P SG ++T
Sbjct: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT--DEASGAFTIDPMSGTLKTSN 1538
Query: 1024 RLDREAVSVYELTAYAVDRGVPPLR-TPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
LDREA S + +A A D + R T V I+V V DVNDN PV F+V + S
Sbjct: 1539 TLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPT 1598
Query: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV--- 1139
+ A D D GPN +++ E +F +D ++GE I EY
Sbjct: 1599 NQTTVIVRADDLDLGPNGTVVFSFAE--TQSMFSIDKYTGE----IQFQQNPSSEYFPIW 1652
Query: 1140 IVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYD 1199
+ ++ T + +R T + ++ ++ L+ V+ + S I + A+
Sbjct: 1653 LQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS--IVTVKAFA 1710
Query: 1200 PD-VSDHLFYSFERGNELQLLVVNQTSGEL 1228
PD + D + YS GNE +L + SG+L
Sbjct: 1711 PDSIQDSMKYSIFSGNEDGVLSLCSKSGQL 1740
Score = 325 bits (834), Expect = 4e-88
Identities = 280/942 (29%), Positives = 428/942 (45%), Gaps = 69/942 (7%)
Query: 333 LVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALD 392
L PE+ T V+ V A D D G G +V+S A + +FSID +G I+
Sbjct: 1592 LSPESPTNQTTVI-VRADDLDLGPNGTVVFSFAETQS-----MFSIDKYTGEIQFQQNPS 1645
Query: 393 RESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPI 452
E +L++ D G P + T ++ + + + D F Y+ + EN E G I
Sbjct: 1646 SEYFPI-WLQLKVTDQGIPARTTTGLLVIHM-EGEDVKISFSHHLYKGLVTENCEAGTSI 1703
Query: 453 LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGR--VDREHMESYE 510
+ ++A D+ ++ F G + +SG ++ +D E +
Sbjct: 1704 VTVKAFAPDSIQDSMKYSIFSGNEDG------VLSLCSKSGQLTVKEPKFLDFEVRNEVQ 1757
Query: 511 LVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTAT 570
L+V A G A +V + + DENDN+P F + Y A V E + V++V AT
Sbjct: 1758 LIVLAESSGHR-----AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFAT 1812
Query: 571 DRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPL 630
D D NGL+ Y+I+SGN F ID+L+G I A LD+E Y+L ++A D G P L
Sbjct: 1813 DLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRL 1872
Query: 631 SNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL 690
SN T + +QV DIND+ P F+ + V + E++ G V H+ D D N+ +S
Sbjct: 1873 SNTT-VIKVQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDL--NSAFIFSF 1928
Query: 691 TGVA-PDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV 749
+ P T F I+ TG V + LD E + Y ++ D ++ V VLDV
Sbjct: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH---YTEGALVVRVLDV 1985
Query: 750 NDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGG 809
NDN P F+ Y + + E VG SV++++A D ++N ISY+I + F+I + G
Sbjct: 1986 NDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSS--KEFSIDPKNG 2043
Query: 810 -VGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVFQSAHYSV 865
+ ++ L LD F ++ ASD L V I I D N + P F Y++
Sbjct: 2044 TIFTISPVLLLDTISTTQF--LVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNL 2101
Query: 866 SVNEDRPMGSTIVVISASDDD-VGENARITYLLEDNLPQFRIDADS------------GA 912
S++ED +GST+V S D D EN + Y + Q ++ G
Sbjct: 2102 SLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY 2161
Query: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972
+ L LD E ++ L I A D+G P + T + + V DVNDN P F + Y V E
Sbjct: 2162 LVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKE 2221
Query: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSV 1032
P + + +SA DRD ++ + Y +G + G F +E +G++ ++ LD E ++
Sbjct: 2222 STPLGSHITVVSANDRDTGSHAEIIYNIISGNE-KGHFYLEENTGVLYLIKPLDYEKMTK 2280
Query: 1033 YELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAV 1092
+ LT A D V + V V D ND+AP F F V EN + S + I A+
Sbjct: 2281 FTLTVQASDAEKKHFSFAV-VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINAL 2339
Query: 1093 DPDEGPNAHIMYQIVEGNI--------PELFQMDIFSGELTALIDLDYEARQEYVIVVQA 1144
D D GP + Y IV +LF +D +G++ A LDYE +Y + VQA
Sbjct: 2340 DFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQA 2399
Query: 1145 -TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVS 1203
+ V V + ++ P+ Q F N+ +IGR+ A D D
Sbjct: 2400 KDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKD----RQLIGRVEASDADAG 2455
Query: 1204 DHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASML 1245
+ G VN+T+G + L R L PL+ S L
Sbjct: 2456 IDGVILYSLGTSSPFFSVNKTNGNIYLIRAL----PLIKSQL 2493
Score = 318 bits (816), Expect = 4e-86
Identities = 279/961 (29%), Positives = 434/961 (45%), Gaps = 76/961 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
P+F +Y V EN+ V V+A D DAG + Y + ++ + E F+I+ S
Sbjct: 1372 PEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI---IDGNTDECFTINEMS 1427
Query: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
G + T ALDRE + L + D G P S+ + V V D NDHSP F Y+ ++
Sbjct: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
Query: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
RE+ E G +L L A D D N Y A+ AF IDP SG + TS +D
Sbjct: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD------EASGAFTIDPMSGTLKTSNTLD 1541
Query: 503 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
RE + A D + G RS TV + + V D NDN P + + + + +
Sbjct: 1542 REARSQHTFSAVARDCSIQ-GSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
Query: 563 VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYA---LR 619
+ V A D D NG V ++ ++ F+ID TGEIQ EY L+
Sbjct: 1601 TTVIVRADDLDLGPNGTVVFSF--AETQSMFSIDKYTGEIQ----FQQNPSSEYFPIWLQ 1654
Query: 620 IRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
++ D G P TGL I + + I F ++ V EN G S++ ++A D
Sbjct: 1655 LKVTDQG-IPARTTTGLLVIHMEGEDVKIS-FSHHLYKGLVTENCEAGTSIVTVKAFAPD 1712
Query: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGP--LDRESVEHYFFGVEARDHGSPPLS 737
+++ ++YS+ D + S +G ++V P LD E V A G
Sbjct: 1713 SIQDS-MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH---R 1768
Query: 738 ASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITG 795
A V V + D NDN P F Y ++E V+ V A D D+ N I Y I
Sbjct: 1769 AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS 1828
Query: 796 GNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDAN 852
GN F I GV +T LDY+ + L++ A+D+ L + + + +TD N
Sbjct: 1829 GNQEEAFQIDALSGV--ITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDIN 1886
Query: 853 THRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL-PQFRIDADSG 911
+ P F + +V + ED G + +S D D+ ++ E N +F ID ++G
Sbjct: 1887 DNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTG 1945
Query: 912 AITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE----VMVNDVNDNAPQFVASHYT 967
+ L LD+E+ Y L I D+ Y E V V DVNDN P F Y
Sbjct: 1946 VVVLVKTLDFEEMTEYELLIQISDS-------VHYTEGALVVRVLDVNDNPPVFSQDFYQ 1998
Query: 968 GLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRR-LD 1026
V E P SVL +SATD +++ N + Y + +F+I+P +G + T+ L
Sbjct: 1999 VTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSK---EFSIDPKNGTIFTISPVLL 2053
Query: 1027 REAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
+ +S + A D G P LR +++ ++D+N+ AP F + + + + E+++VGS +
Sbjct: 2054 LDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTL 2113
Query: 1087 AQITAVDPD-EGPNAHIMYQIVEGNIPELFQMD--IFSGE--------LTALIDLDYEAR 1135
+ +D D N ++ Y I+ GN F ++ F E L L LD EA
Sbjct: 2114 VTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREAS 2173
Query: 1136 QEYVIVVQATSA---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGI- 1191
+ +V+ A+ + PL S A + ++++D NDN P NF L +Y ++ ++ P G
Sbjct: 2174 ASHELVILASDSGCPPLSSTAVISIQVLDVNDNPP---NFSSL--SYHTHVKESTPLGSH 2228
Query: 1192 IGRIPAYDPDVSDH--LFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVT 1249
I + A D D H + Y+ GNE + + +G L L + LD + ++ V +
Sbjct: 2229 ITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQAS 2288
Query: 1250 D 1250
D
Sbjct: 2289 D 2289
Score = 301 bits (772), Expect = 5e-81
Identities = 262/997 (26%), Positives = 442/997 (44%), Gaps = 85/997 (8%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ HP F + + + + + GTA+ A+D D+G G + YS+A S +F+ID
Sbjct: 475 DNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA----SPQPGVFAID 530
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP--VFEQAQ 437
G++ +L L + A+D G A +V V ++ +HSP FE
Sbjct: 531 RALGVLFLNGSLGAGEQRELTLTLRAEDQGV-HPQAALLVLTVVIEKREHSPSWTFEHLV 589
Query: 438 YRETLRENVEEGYPILQLRATD-GDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIS 496
Y+ + E++ +LQ +A G + LRY + +A F I P +G I
Sbjct: 590 YQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSL-----EPSVDSAMFGIRPYTGWIY 644
Query: 497 TSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE 556
+ D E ++Y V A ++ ++ + V + V DENDN+P F +V E
Sbjct: 645 LRRQFDYESTQTYNFRVFAWIP-EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE 703
Query: 557 DVRPHTVVLRVTATDRDKDANGLVHYNII------------------------------- 585
P V+ ++TA D D NG + Y ++
Sbjct: 704 SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFS 763
Query: 586 ------SGNSRGHFAIDSL-----TGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNT 634
S + F + SL GE+ LD E + + + D G PP N T
Sbjct: 764 GTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPP-RNAT 822
Query: 635 GLASIQVVDINDHIPIF----VSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL 690
+ V DIND+ P F V VLE P+ V + A D D G NA + YS+
Sbjct: 823 MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 882
Query: 691 TGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVN 750
+ F I++ G + + L + Y V A D G PPL A V + V+ ++
Sbjct: 883 SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLS 942
Query: 751 DNRPEFTMKEYHLRLNED---AAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQ 807
R + HL + E+ + + + S + + N + + I + F I +
Sbjct: 943 KGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSS 1002
Query: 808 GGVGLVTLALPLDYKQERYFKLVLT--ASDRALHDHCYVHINITDANTHRPVFQSAHYSV 865
G ++ L + F+++ T + + +L ++ I++ D N H P FQ +
Sbjct: 1003 TGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVI 1062
Query: 866 SVNEDRPMGSTIVVISASDDDVG-ENARITYLLEDNLP---QFRIDADSGAITLQAPLDY 921
SV E+ P+G+ + V +A DDD N+RI Y +E + P F I G + + LD
Sbjct: 1063 SVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDR 1122
Query: 922 EDQVTYTLAITARDNGI---PQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFT 978
E T L +TA D + ++ + ++++ DVND+ P F+ S V ED +
Sbjct: 1123 ESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGS 1181
Query: 979 SVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAY 1038
V I+A D D NG+V Y+ +G + + F ++ +SG++ T LD E + + LT
Sbjct: 1182 LVHHITAHDPDEGRNGKVTYSILSGNE-NMTFMLDESSGLLTTTCPLDYEMKTQHILTVL 1240
Query: 1039 AVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGP 1098
A+D G P L + ++ V V DVND APVF +E VKEN G V ++ A+D D G
Sbjct: 1241 ALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGV 1300
Query: 1099 NAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEY---VIVVQATSAPLVSRATV 1155
N+ + ++I+ G ELF+++ +GE+ LD E ++ + V+V L S T+
Sbjct: 1301 NSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTI 1360
Query: 1156 HVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDH--LFYSFERG 1213
+ D+ND++P + + ++Y + ++ + A D D ++ + Y G
Sbjct: 1361 LCTVEDENDHAP-----EFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDG 1415
Query: 1214 NELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
N + +N+ SGEL +R LD + ++++ +D
Sbjct: 1416 NTDECFTINEMSGELSTTRALDREQISNFTLVILCSD 1452
Score = 216 bits (551), Expect = 2e-55
Identities = 253/1008 (25%), Positives = 399/1008 (39%), Gaps = 155/1008 (15%)
Query: 335 PENEAAGTAVLR-------------VVAQDPDAGEAGRLVYSLA-ALMNSRSLELFSIDP 380
PE E G V R V A D D+G G + YSL ++ + + F IDP
Sbjct: 54 PETELWGAIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDP 113
Query: 381 QSGLIRTAAALDRESMERHY-LRVTAQDHGSPR----------LSATTMVAVTVADRNDH 429
G I + +DRE Y L V A+D R LSA V V + D ND+
Sbjct: 114 HDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDN 173
Query: 430 SPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID 489
PVF + Y ++ + + G I+ + ATD D+ + Y + ++ F ID
Sbjct: 174 HPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI-----PGNVSSLFTID 228
Query: 490 PRSGLISTSGRV--------DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDN 541
+GL S + D+E M S E+ + + H ++ ++
Sbjct: 229 STTGLYSPEVEILSAVNFSADKEVMNSLEMFL--------------PLLRHFKKVERDEE 274
Query: 542 APQFSEKRYVAQ----VREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDS 597
A +EK++ A +R R H L+V D Y G
Sbjct: 275 A---AEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGE----- 326
Query: 598 LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHI-------PI 650
G I + PL +L + AQD G GL ++ D+ HI
Sbjct: 327 --GIIYLTLPLSHLESTTLSLMVSAQDGG--------GLTAVINADVTIHIFQTTLAPAE 376
Query: 651 FVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSV 710
F + V E+ P + ++A + + + Y ++ F I+ G +
Sbjct: 377 FERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP-IFYRISSGDLGGKFSIHPRLGTIRT 435
Query: 711 SGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAA 770
PLD E+ V+A+ GS P +S V +TV+DVNDN P F +R+++
Sbjct: 436 RKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTP 494
Query: 771 VGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFK 828
GT++ A DRD+ N I Y I FAI +G++ L L ++R
Sbjct: 495 PGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDR--ALGVLFLNGSLGAGEQRELT 551
Query: 829 LVLTASDRALHDHC--YVHINITDANTHRP--VFQSAHYSVSVNED-RPMGSTIVVISAS 883
L L A D+ +H V + + H P F+ Y V V+E PM + +
Sbjct: 552 LTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP 611
Query: 884 DDDVGENARITYLLEDNL--PQFRIDADSGAITLQAPLDYEDQVTYTLAITA--RDNGIP 939
+ + Y LE ++ F I +G I L+ DYE TY + A ++G
Sbjct: 612 LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL 671
Query: 940 QKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYT 999
Q TT + V V D NDN+P F+ V E P + +I+A D D+ NG++ Y
Sbjct: 672 QNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYF 730
Query: 1000 FQNGEDGDGD-FTIEPTSGIVRTVR----------------------------------- 1023
+ DG F + P +G T+
Sbjct: 731 LLS----DGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
Query: 1024 ---------RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF----PAE 1070
LDRE +E+T DRG PP +++ V V D+NDN P F P +
Sbjct: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
Query: 1071 EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDL 1130
E V+V E V +V + A DPDEG NA + Y + + + F++D +GE+ L
Sbjct: 847 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTIL 906
Query: 1131 DYEARQEYVIVVQATS---APLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTF 1187
Y+ R Y + V AT PL +A V+++++ + +++ I N T
Sbjct: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQ-NIRHLIIPENLKPTK 965
Query: 1188 PSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLD 1235
+I + L +S ++ ++ ++G+L LS++LD
Sbjct: 966 IMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
Score = 212 bits (540), Expect = 4e-54
Identities = 189/665 (28%), Positives = 307/665 (46%), Gaps = 48/665 (7%)
Query: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
+ E+ G V V D D A ++S A N + F+ID +G++ LD
Sbjct: 1900 ITEDSLPGVIVTHVSVHDVDLNSA--FIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDF 1955
Query: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL 453
E M + L + D S + +V V V D ND+ PVF Q Y+ T+ E++ GY +L
Sbjct: 1956 EEMTEYELLIQISD--SVHYTEGALV-VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVL 2012
Query: 454 QLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDR-EHMESYELV 512
L ATD ++ N N+ YR + +++ F IDP++G I T V + + + + +
Sbjct: 2013 TLSATDLES--NENISYRIL-------SSSKEFSIDPKNGTIFTISPVLLLDTISTTQFL 2063
Query: 513 VEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDR 572
VEASD G P R+ T+ V I + D N+ AP+F+ K Y + ED + ++ + D
Sbjct: 2064 VEASDGGN-PDLRALTL-VEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDH 2121
Query: 573 D-KDANGLVHYNIISGNSRGHFAIDSL----------TGEIQVVAPLDFEAEREYALRIR 621
D N V Y+IISGNS+ +F +++ G + ++ LD EA + L I
Sbjct: 2122 DWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVIL 2181
Query: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
A D+G PPLS+ T + SIQV+D+ND+ P F S + V E+ PLG + + A D D G
Sbjct: 2182 ASDSGCPPLSS-TAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTG 2240
Query: 682 ENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASAS 741
+A + Y++ F + TG + + PLD E + + V+A D S A
Sbjct: 2241 SHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSF-AV 2299
Query: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN--SAISYQI------ 793
V V+VLD ND+ P+F + + E+ + +++ S+ A+D DA ++Y I
Sbjct: 2300 VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFL 2359
Query: 794 TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHINITDAN 852
T G + + G + LDY+ + L + A D+ V ++I +
Sbjct: 2360 THGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGID 2419
Query: 853 THRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGA 912
P+F Y ++ E I + ASD D G + I Y L + P F ++ +G
Sbjct: 2420 EFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGN 2479
Query: 913 ITL-------QAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
I L ++ L+ ED + + + + + T +V V + F +S
Sbjct: 2480 IYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSF 2539
Query: 966 YTGLV 970
LV
Sbjct: 2540 SISLV 2544
Score = 186 bits (473), Expect = 3e-46
Identities = 243/1035 (23%), Positives = 405/1035 (39%), Gaps = 144/1035 (13%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ HP F Y T + + GT ++ V+A D D+G G + Y L+ LF+ID
Sbjct: 172 DNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTID 228
Query: 380 PQSGLIRTAAAL--------DRESME---------RHYLRVTAQDHGSPRLSATTMVAVT 422
+GL + D+E M RH+ +V + + + +
Sbjct: 229 STTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEAS----- 283
Query: 423 VADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAA 482
F + + R L L+ D A + R+V A
Sbjct: 284 -------RGWFMRFKGRRHLH----------YLKVQDEAASADGEAAARYVANLAKILGE 326
Query: 483 AAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA 542
+ P S L ST + L+V A D G +A V +HI + A
Sbjct: 327 GIIYLTLPLSHLEST----------TLSLMVSAQDGGGLTAVINADVTIHIF---QTTLA 373
Query: 543 P-QFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGE 601
P +F +Y V EDV + + V A + +++ + Y I SG+ G F+I G
Sbjct: 374 PAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGT 432
Query: 602 IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVL 661
I+ PLD E + L ++AQ P S+ +I V+D+ND+ P F+ T ++ +
Sbjct: 433 IRTRKPLDHETQPVVVLTVQAQLGSAPACSSTE--VNITVMDVNDNHPAFLRTSDEIRIS 490
Query: 662 ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEH 721
+ P G ++ +A D D G N + YS+ P F I+ A G + ++G L
Sbjct: 491 QTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV-FAIDRALGVLFLNGSLGAGEQRE 549
Query: 722 YFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKE--YHLRLNEDAAVGTSVVSVT 779
+ A D G P +A +TV V++ ++ P +T + Y + ++E + T ++
Sbjct: 550 LTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQ 608
Query: 780 A---VDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTA--- 833
A + A S + Y + F I G + L DY+ + + + A
Sbjct: 609 AHPLGPQRAASPLRYSLEPSVDSAMFGIRPY--TGWIYLRRQFDYESTQTYNFRVFAWIP 666
Query: 834 SDRALHD-HCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENAR 892
D L + V + + D N + P F + V E I I+A D D G+N +
Sbjct: 667 EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQ 726
Query: 893 ITYLLEDNLPQFRIDADSG------AIT-------------------LQA---------- 917
+ Y L + F+++ ++G IT LQA
Sbjct: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
Query: 918 ---------PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF----VAS 964
LD E + + + + D G P + T V V V D+NDN P F
Sbjct: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
Query: 965 HYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRR 1024
V E P V + A D D N V Y+ + ED F I+ +G +RT
Sbjct: 847 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV-SSEDSSDHFKIDANNGEIRTTTI 905
Query: 1025 LDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGS 1084
L + Y ++ A D+GVPPL+ + + V ++ + + + EN
Sbjct: 906 LSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTK 965
Query: 1085 VVAQITAVDP-DEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143
+++ I + D + N + + IV + F++D +G+L +LDYE Y+ V
Sbjct: 966 IMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVI 1025
Query: 1144 AT----SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAY 1198
T + L S + + + DQND+SP + I V + + P G ++ A
Sbjct: 1026 TTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELI-----VISVEENVPIGTLVYVFNAK 1080
Query: 1199 DPD---VSDHLFYSFERGNE-LQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD---- 1250
D D ++ + Y E N +++ + G L +LD + VT +D
Sbjct: 1081 DDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVN 1140
Query: 1251 ----GLHSVTAQCVL 1261
L S+TAQ V+
Sbjct: 1141 VTDRRLRSLTAQIVI 1155
Score = 127 bits (320), Expect = 1e-28
Identities = 106/405 (26%), Positives = 181/405 (44%), Gaps = 33/405 (8%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
N P+F +Y + E+ G+ ++ D D Y ++++ S F ++
Sbjct: 2089 NYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTREN--TYVEYSIISGNSQNNFHVE 2146
Query: 380 P----------QSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDH 429
Q G + +LDRE+ H L + A D G P LS+T ++++ V D ND+
Sbjct: 2147 TKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDN 2206
Query: 430 SPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID 489
P F Y ++E+ G I + A D D +A + Y + F ++
Sbjct: 2207 PPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIIS-----GNEKGHFYLE 2261
Query: 490 PRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKR 549
+G++ +D E M + L V+ASD ++ + V ++VLD+ND+APQF
Sbjct: 2262 ENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK---HFSFAVVFVSVLDDNDHAPQFMFSS 2318
Query: 550 YVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIIS------GNSRGH--FAIDSLTGE 601
+ V E++ + + + A D D G + Y+I+S G S H F ID LTG+
Sbjct: 2319 FSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGD 2378
Query: 602 IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVL 661
I LD+E +Y L ++A+D G S + + + I++ PIF + ++
Sbjct: 2379 IHAKQILDYENGNKYCLTVQAKDKGDATASL---VVWVDIEGIDEFEPIFTQDQYFFTLP 2435
Query: 662 ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATG 706
E + ++A DAD G + + YSL +P F +N G
Sbjct: 2436 EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPF--FSVNKTNG 2478
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 334 bits (857), Expect = 8e-91
Identities = 295/999 (29%), Positives = 441/999 (44%), Gaps = 100/999 (10%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSL------------------ 364
P+FP + Q V E GTA VA DPDAG Y+L
Sbjct: 165 PRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLR 224
Query: 365 --------AALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSAT 416
+ L+ S L +D + LDRE H L++ A D G PR +
Sbjct: 225 YRTPGPLPSPLLPGSSSPLEPLD-----LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL 279
Query: 417 TMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRF---- 472
V + V D ND+ PVFEQ +YR +RE+ + G + ++RATD D PN +RY
Sbjct: 280 LSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQ 339
Query: 473 ---VGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
G AA F ++ SG++ +DRE ++LVVEA D G E P ATV
Sbjct: 340 VPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE--PEVATV 397
Query: 530 RVHITVLDENDNAPQ----FSEKRYVAQVREDVRPHTVVLRVTATDRDKD------ANGL 579
RV I VLD NDN P F + VA+V E RP V RV+ +D D D A G
Sbjct: 398 RVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGE 457
Query: 580 VHYNIISGN-------SRGHFAIDSLTGE------IQVVAPLDFEAEREYALRIRAQDAG 626
+ + G+ G FA+ L G + V PLD E+ Y L + A DAG
Sbjct: 458 LGVGLGDGSISLSLEGGEGDFAL--LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAG 515
Query: 627 RPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADH--GENA 684
PPLS L ++V D+ND P+F ++ SV E A G V+ + A DAD ++A
Sbjct: 516 SPPLSTEETLL-LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
Query: 685 RLEYSLTGVAP-----------------DTPFVINSATGWVSVSGPLDRESVEHYFFGVE 727
L Y++ ++ F I+S +G +S LDRE E V
Sbjct: 575 WLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV 634
Query: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
A+D G PPLSA+ V++TV DVNDN P F + Y+ + E A VG + VTA D D+
Sbjct: 635 AQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGL 694
Query: 787 -SAISYQITGG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH 841
I Y + G F I G V+ + + Y LV L
Sbjct: 695 YGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQ 754
Query: 842 CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDN 900
+V +++ D N + PVF + Y S++++ G+ I+ + A+D D G + Y L+ N
Sbjct: 755 AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN 814
Query: 901 LPQ-FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAP 959
+ F ID+ +G I L PL + + T +L ++A+D G V + +
Sbjct: 815 VSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPA 874
Query: 960 QFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIV 1019
+F YT LV ED P + + + A + +++ + Y +G+ G G F+I P G +
Sbjct: 875 EFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLG-GKFSIHPRLGTI 932
Query: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
RT + LD E V LT A G P + + + V DVNDN P F E+R+ +
Sbjct: 933 RTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQT 991
Query: 1080 SIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYV 1139
+ G+ + A D D G N I Y I P +F +D G L L ++E
Sbjct: 992 TPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAIDRALGVLFLNGSLGAGEQRELT 1050
Query: 1140 IVVQATSAPLVSRATVHVR--LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPA 1197
+ ++A + +A + V ++++ ++SP +++ VS + +
Sbjct: 1051 LTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP 1110
Query: 1198 YDPD-VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLD 1235
P + L YS E + + + +G + L R+ D
Sbjct: 1111 LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFD 1149
Score = 318 bits (814), Expect = 7e-86
Identities = 264/826 (31%), Positives = 378/826 (45%), Gaps = 67/826 (8%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGR-------LVYSLAALMNSRSLEL 375
P F Q +Y+ V E A GT V+ V A D D EAG V L+A N SL+
Sbjct: 537 PLFSQQHYKASVSEAAAPGTVVMWVSASDAD--EAGSDHAWLRYTVVQLSAPCNLGSLQS 594
Query: 376 -----------FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVA 424
F+ID +SG I T LDRE E L+V AQD G P LSAT +V++TV
Sbjct: 595 KMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
Query: 425 DRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAA 484
D ND+ P+F + Y T+ E+ G+ LQ+ A+D D+ + Y A
Sbjct: 655 DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY-DGFLSYEAPQ 713
Query: 485 AFEIDPRSGLISTSGRVDREH-MESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAP 543
AF IDP G I S +DRE +Y+L+VEA D G SA V + + D NDN P
Sbjct: 714 AFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD----GGGLSAQAFVRVDLEDVNDNHP 769
Query: 544 QFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQ 603
F+ YV + ++ +P T ++ V ATD+D G V Y +I GN F IDS TG I
Sbjct: 770 VFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIY 829
Query: 604 VVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHI-------PIFVSTPF 656
+ PL +L + AQD G GL ++ D+ HI F +
Sbjct: 830 LTLPLSHLESTTLSLMVSAQDGG--------GLTAVINADVTIHIFQTTLAPAEFERPKY 881
Query: 657 QVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDR 716
V E+ P + ++A + + + Y ++ F I+ G + PLD
Sbjct: 882 TFLVYEDVPEDSPIGTVKAREPLNSSEP-IFYRISSGDLGGKFSIHPRLGTIRTRKPLDH 940
Query: 717 ESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVV 776
E+ V+A+ GS P +S V +TV+DVNDN P F +R+++ GT++
Sbjct: 941 ETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALY 999
Query: 777 SVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTAS 834
A DRD+ N I Y I FAI +G++ L L ++R L L A
Sbjct: 1000 LARAEDRDSGRNGLIRYSIASPQP-GVFAIDR--ALGVLFLNGSLGAGEQRELTLTLRAE 1056
Query: 835 DRALHDHC--YVHINITDANTHRP--VFQSAHYSVSVNED-RPMGSTIVVISASDDDVGE 889
D+ +H V + + H P F+ Y V V+E PM + +
Sbjct: 1057 DQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRA 1116
Query: 890 NARITYLLEDNL--PQFRIDADSGAITLQAPLDYEDQVTYTLAITA--RDNGIPQKADTT 945
+ + Y LE ++ F I +G I L+ DYE TY + A ++G Q TT
Sbjct: 1117 ASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT 1176
Query: 946 YVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGED 1005
+ V V D NDN+P F+ V E P + +I+A D D+ NG++ Y +
Sbjct: 1177 VI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLS--- 1232
Query: 1006 GDGD-FTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNA 1064
DG F + P +G + LDRE +E+T DRG PP +++ V V D+NDN
Sbjct: 1233 -DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 1291
Query: 1065 PVF----PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQI 1106
P F P +E V+V E V +V + A DPDEG NA + Y +
Sbjct: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 303 bits (775), Expect = 2e-81
Identities = 292/996 (29%), Positives = 439/996 (44%), Gaps = 122/996 (12%)
Query: 369 NSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRND 428
+S L+ F + P +G+IRTA LDRE + HY V A L A V + V D ND
Sbjct: 109 DSPLLDDFHVHPDTGIIRTARRLDRERRD-HYSFVAA-----TLLGAVVQVEIRVNDVND 162
Query: 429 HSPVFEQAQYRETLRENVEE------------------------GYPILQLRATDGD-AP 463
HSP F ++L+ +V E GY ++Q D A
Sbjct: 163 HSPRFP----LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAG 218
Query: 464 PNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPG 523
P LRYR GP + ++ ++P ++ R+DRE ++ L +EA D G+
Sbjct: 219 PFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLR--RLDREEAAAHRLQIEAWDGGRP-- 274
Query: 524 PRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYN 583
R+ + V + VLDENDN P F + Y A VRED +P V RV ATDRD NG V Y+
Sbjct: 275 RRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYS 334
Query: 584 I----ISGNSRG--------HFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLS 631
+ + G G +FA++ L+G ++V PLD EA+ + L + A+D G P
Sbjct: 335 VRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEP-E 393
Query: 632 NNTGLASIQVVDINDHIP----IFVSTPFQVSVLENAPLGHSVIHIQAVDAD-------- 679
T SI V+D+ND+ P +F++ V E A G V + DAD
Sbjct: 394 VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453
Query: 680 -HGE------NARLEYSLTGVAPDTPFVINSATG--WVSVSGPLDRESVEHYFFGVEARD 730
GE + + SL G D + G ++ V GPLDRES + Y + A D
Sbjct: 454 ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA-- 788
GSPPLS ++ + V D+ND P F+ + Y ++E AA GT V+ V+A D D +
Sbjct: 514 AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDH 573
Query: 789 ---------ISYQITGGNTRNR----------FAISTQGGVGLVTLALPLDYKQERYFKL 829
+S G+ +++ FAI ++ G ++ LD + + +L
Sbjct: 574 AWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGA--ISTIRTLDREVQEAVEL 631
Query: 830 VLTASDRA---LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDD 886
+ A D L C V I + D N + P+F Y+ ++ E P+G + ++ASD D
Sbjct: 632 KVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD 691
Query: 887 VGENARITYLLEDNL-----PQ-FRIDADSGAITLQAPLDYE-DQVTYTLAITARDNGIP 939
G I Y L D PQ FRID G I + +D E D TY L + A+D G
Sbjct: 692 SGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG-- 749
Query: 940 QKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYT 999
+ +V V + DVNDN P F S Y +S++ P T ++ + ATD+D+ G V Y
Sbjct: 750 GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE 809
Query: 1000 FQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQD 1059
G + FTI+ T+GI+ L + L A D G + + +
Sbjct: 810 LIPG-NVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQ 868
Query: 1060 VNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDI 1119
F ++ V E+ S + + A +P + I Y+I G++ F +
Sbjct: 869 TTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHP 927
Query: 1120 FSGELTALIDLDYEARQEYVIVVQAT--SAPLVSRATVHVRLVDQNDNSPVLNNFQILFN 1177
G + LD+E + V+ VQA SAP S V++ ++D NDN P L
Sbjct: 928 RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA-----FLRT 982
Query: 1178 NYVSNRSDTFPSG---IIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKL 1234
+ S T P G + R D + + YS + + +++ G L L+ L
Sbjct: 983 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI-ASPQPGVFAIDRALGVLFLNGSL 1041
Query: 1235 DNNRPLVASMLVTVTD-GLHSVTAQCVLRVVIITEE 1269
++ + D G+H A VL VVI E
Sbjct: 1042 GAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKRE 1077
Score = 301 bits (770), Expect = 9e-81
Identities = 282/998 (28%), Positives = 440/998 (44%), Gaps = 93/998 (9%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRS---------L 373
P F Q Y+ V E+ G V RV A D D G G + YS+ A +
Sbjct: 294 PVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDA 353
Query: 374 ELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVF 433
F+++ SG++R LDRE+ H L V A+D G+ AT V++ V D ND+ P
Sbjct: 354 AYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI 413
Query: 434 EQAQYRE----TLRENVEEGYPILQLRATDGDAP---------------PNANLRYRFVG 474
E + E G + ++ +D D + ++ G
Sbjct: 414 HVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEG 473
Query: 475 PPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHIT 534
A P + G +DRE + YEL++ A+D G P T+ + +
Sbjct: 474 GEGDFALLPGG---PPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVA 530
Query: 535 VLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDAN--GLVHYNII------- 585
D ND P FS++ Y A V E P TVV+ V+A+D D+ + + Y ++
Sbjct: 531 --DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
Query: 586 ----------SGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTG 635
+ FAIDS +G I + LD E + L++ AQD G PPLS T
Sbjct: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSA-TC 647
Query: 636 LASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTG--V 693
L SI V D+ND+ PIF + ++ E+AP+GH + + A DAD G +EYSL +
Sbjct: 648 LVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFL 707
Query: 694 APDTP--FVINSATGWVSVSGPLDRE-SVEHYFFGVEARDHGSPPLSASASVTVTVLDVN 750
+ + P F I+ G + VS +DRE Y VEA+D G LSA A V V + DVN
Sbjct: 708 SYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVN 765
Query: 751 DNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN--SAISYQITGGNTRNRFAISTQG 808
DN P F Y ++++ GT +++V A D+D+ ++Y++ GN + F I +
Sbjct: 766 DNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST- 824
Query: 809 GVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVFQSAHYSV 865
G++ L LPL + + L+++A D + V I+I F+ Y+
Sbjct: 825 -TGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 883
Query: 866 SVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLPQFRIDADSGAITLQAPLDYED 923
V ED P S I + A + + + I Y + D +F I G I + PLD+E
Sbjct: 884 LVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHET 942
Query: 924 QVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQI 983
Q L + A+ P +T V + V DVNDN P F+ + +S+ PP T++
Sbjct: 943 QPVVVLTVQAQLGSAPA-CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
Query: 984 SATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRG 1043
A DRD+ NG ++Y+ + + G F I+ G++ L LT A D+G
Sbjct: 1002 RAEDRDSGRNGLIRYSIASPQPGV--FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG 1059
Query: 1044 VPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPN---A 1100
V P + + V+++ +++P + E +V+ + + + + GP +
Sbjct: 1060 VHPQAALLVLTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS 1118
Query: 1101 HIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAP-----LVSRATV 1155
+ Y + +F + ++G + DYE+ Q Y V A VS TV
Sbjct: 1119 PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS-TTV 1177
Query: 1156 HVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDH---LFYSFER 1212
VR+ D+NDNSP + +LF + P G+IG+I A D D + L++
Sbjct: 1178 IVRVWDENDNSPTFLH-DVLF---LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 1233
Query: 1213 GNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
G + +N +GEL LD M V VTD
Sbjct: 1234 G---KFFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268
Score = 202 bits (513), Expect = 6e-51
Identities = 185/696 (26%), Positives = 303/696 (43%), Gaps = 33/696 (4%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSL-AALMNSRSLELFSI 378
+ P F + Y + E+ G L+V A D D+G G + YSL ++ + + F I
Sbjct: 658 DNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRI 717
Query: 379 DPQSGLIRTAAALDRESMERHY-LRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
DP G I + +DRE Y L V A+D G LSA V V + D ND+ PVF +
Sbjct: 718 DPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPST 775
Query: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Y ++ + + G I+ + ATD D+ + Y + ++ F ID +G+I
Sbjct: 776 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI-----PGNVSSLFTIDSTTGIIYL 830
Query: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAP-QFSEKRYVAQVRE 556
+ + + L+V A D G +A V +HI + AP +F +Y V E
Sbjct: 831 TLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF---QTTLAPAEFERPKYTFLVYE 887
Query: 557 DVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREY 616
DV + + V A + +++ + Y I SG+ G F+I G I+ PLD E +
Sbjct: 888 DVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVV 946
Query: 617 ALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAV 676
L ++AQ P S+ +I V+D+ND+ P F+ T ++ + + P G ++ +A
Sbjct: 947 VLTVQAQLGSAPACSSTE--VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAE 1004
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPL 736
D D G N + YS+ P F I+ A G + ++G L + A D G P
Sbjct: 1005 DRDSGRNGLIRYSIASPQPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ 1063
Query: 737 SASASVTVTVLDVNDNRPEFTMKE--YHLRLNEDAAVGTSVVSVTA---VDRDANSAISY 791
+A +TV V++ ++ P +T + Y + ++E + T ++ A + A S + Y
Sbjct: 1064 AALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRY 1122
Query: 792 QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTA---SDRALHD-HCYVHIN 847
+ F I G + L DY+ + + + A D L + V +
Sbjct: 1123 SLEPSVDSAMFGIRPY--TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVR 1180
Query: 848 ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRID 907
+ D N + P F + V E I I+A D D G+N ++ Y L + F+++
Sbjct: 1181 VWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMN 1240
Query: 908 ADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF----VA 963
++G + LD E + + + + D G P + T V V V D+NDN P F
Sbjct: 1241 PNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 1300
Query: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYT 999
V E P V + A D D N V Y+
Sbjct: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYS 1336
Score = 176 bits (445), Expect = 4e-43
Identities = 165/598 (27%), Positives = 251/598 (41%), Gaps = 36/598 (6%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ HP F Y T + + GT ++ V+A D D+G G + Y L+ LF+ID
Sbjct: 766 DNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTID 822
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
+G+I L L V+AQD G V + + FE+ +Y
Sbjct: 823 STTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYT 882
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNAN--LRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
+ E+V E PI ++A + P N++ + YR + F I PR G I T
Sbjct: 883 FLVYEDVPEDSPIGTVKARE---PLNSSEPIFYRI-----SSGDLGGKFSIHPRLGTIRT 934
Query: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
+D E L V+A P ++ V+ITV+D NDN P F ++ +
Sbjct: 935 RKPLDHETQPVVVLTVQAQ---LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQT 991
Query: 558 VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYA 617
P T + A DRD NGL+ Y+I S G FAID G + + L +RE
Sbjct: 992 TPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELT 1050
Query: 618 LRIRAQDAGRPPLSNNTGLASIQVVDINDHIP--IFVSTPFQVSVLENAPLGHSVIHIQA 675
L +RA+D G P + L V++ +H P F +QV V E+ ++ QA
Sbjct: 1051 LTLRAEDQGVHPQA--ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
Query: 676 VDADHGENAR-LEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
A L YSL F I TGW+ + D ES + Y F V A
Sbjct: 1109 HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 1168
Query: 735 PL-SASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISY 791
L + S +V V V D NDN P F L++ E + +TA+D D+ N + Y
Sbjct: 1169 FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLY 1228
Query: 792 QITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINI 848
+ + +T G + + LD + + ++ + +DR + V++++
Sbjct: 1229 FLLSDGKFFKMNPNT----GELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSV 1284
Query: 849 TDANTHRPVFQSA----HYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLP 902
TD N +RP F V V E +P+ + + A D D G NA +TY + P
Sbjct: 1285 TDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARP 1342
Score = 107 bits (268), Expect = 1e-22
Identities = 100/389 (25%), Positives = 160/389 (41%), Gaps = 54/389 (13%)
Query: 859 QSAHYSVSVNEDRP----MGSTIVVISASDDDVGENARITYLLEDN--LPQFRIDADSGA 912
Q + ++SV+E P +G + A+ G ++ +D+ L F + D+G
Sbjct: 65 QLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGI 124
Query: 913 ITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSE 972
I LD E + Y+ + Q VE+ VNDVND++P+F VSE
Sbjct: 125 IRTARRLDRERRDHYSFVAATLLGAVVQ------VEIRVNDVNDHSPRFPLDSLQLDVSE 178
Query: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGD----------------------- 1009
+PP T+ A D DA YT D D
Sbjct: 179 LSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPG 238
Query: 1010 --FTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF 1067
+EP ++ +RRLDRE + + L A D G P +S+++ V D NDN PVF
Sbjct: 239 SSSPLEPLDLVL--LRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVF 296
Query: 1068 PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIP------------ELF 1115
+E+ V+E++ G+ V ++ A D D GPN + Y + +P F
Sbjct: 297 EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
Query: 1116 QMDIFSGELTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNSPVLNNF 1172
++ SG + LD EA+ + +VV+A + P V+ V + ++D NDN P ++
Sbjct: 357 AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVL 416
Query: 1173 QILFNNYVSNRSDTFPSGIIGRIPAYDPD 1201
+ P + R+ D D
Sbjct: 417 FLTEGGVARVSEGARPGDYVARVSVSDAD 445
Score = 77.4 bits (189), Expect = 2e-13
Identities = 85/326 (26%), Positives = 134/326 (41%), Gaps = 54/326 (16%)
Query: 970 VSEDAPPFTSVLQISATDRDAHAN-GRVQYTFQNGEDGD--GDFTIEPTSGIVRTVRRLD 1026
V E PP T V I A A G + ++ +D DF + P +GI+RT RRLD
Sbjct: 73 VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
Query: 1027 REAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVV 1086
RE Y A + L V +++ V DVND++P FP + ++ V E S G+
Sbjct: 133 RERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAF 186
Query: 1087 AQITAVDPDEGPNAHIMYQIVE-GNIPE-----LFQM----------DIFSG-------- 1122
A DPD G + Y +V+ ++P+ FQ+ + G
Sbjct: 187 RLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL 246
Query: 1123 ELTALIDLDYEARQEYVIVVQATSAPLVSRA---TVHVRLVDQNDNSPVLNNFQILFNNY 1179
+L L LD E + + ++A R +V +R++D+NDN PV +
Sbjct: 247 DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY----R 302
Query: 1180 VSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFE-RGNEL-------------QLLVVNQTS 1225
+ R D P + R+ A D D+ + F + R ++ V + S
Sbjct: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
Query: 1226 GELRLSRKLDNNRPLVASMLVTVTDG 1251
G +R+ R LD ++V DG
Sbjct: 363 GVVRVWRPLDREAQAWHQLVVEARDG 388
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 323 bits (828), Expect = 2e-87
Identities = 241/743 (32%), Positives = 369/743 (49%), Gaps = 49/743 (6%)
Query: 418 MVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPI------LQLRATDGDAPPNANLRYR 471
++A +A S + ++ Y T+RE + E PI L + + +A+L YR
Sbjct: 8 LLAALIACLRLDSAIAQELIY--TIREELPENVPIGNIPKDLNISHINAATGTSASLVYR 65
Query: 472 FVGPPAARAAAAAAFEIDPRSG-LISTSGRVDREHMESYELVVEASDQGQE------PGP 524
V ++A A ++ +G + +TS R+DRE + + E ++ E P
Sbjct: 66 LV----SKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPND 121
Query: 525 RSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNI 584
+++ I V D NDNAP F + E+ ++ +ATD D NG+ HY +
Sbjct: 122 FFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL 181
Query: 585 ISGNSR-GHFAIDSLTGE----IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASI 639
++G S G +++ GE + V LD E + Y ++I+ +D G P S+ T + +
Sbjct: 182 LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSS-TAILQV 240
Query: 640 QVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTG-VAPDTP 698
V D+ND+ P+F +V + ENAP+G SVI + A DAD G NA + Y VAP T
Sbjct: 241 TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300
Query: 699 --FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEF 756
F +N+ TG ++V LDRE + V A D S P A A+VT+ V DVNDN P
Sbjct: 301 RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP--ARATVTINVTDVNDNPPNI 358
Query: 757 TMKEY------HLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQG 808
++ + L+E V T + +T D+D N + I + A+
Sbjct: 359 DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ 418
Query: 809 GVGLVTLALPLDYKQERYFKLVLTASDR---ALHDHCYVHINITDANTHRPVFQSAHYSV 865
+ L T +L LDY+ + F + ASD +L+ V + + D N + P+F +
Sbjct: 419 YL-LETSSL-LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 866 SVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQV 925
SV+E+ G + ISA+D+D G+NA I Y L N F +D +G +T D E+Q
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQE 536
Query: 926 TYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISA 985
+ +TARDNG P V V V D NDN+P+F +H+ VSE+ P +++V I+
Sbjct: 537 RFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITV 596
Query: 986 TDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVP 1045
TD DA N V + N D +F ++P SG++++ DRE S Y A D G P
Sbjct: 597 TDADAGENKAVTLSILNDND---NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653
Query: 1046 PLRTPVSIQVMVQDVNDNAPVF---PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
P + + + V DVNDN+PV P+ V ++I GSVVA++ AVD D G NA +
Sbjct: 654 PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713
Query: 1103 MYQIVEGNIPELFQMDIFSGELT 1125
Y IV GN LF++D +G +T
Sbjct: 714 KYTIVSGNNKGLFRIDPVTGNIT 736
Score = 259 bits (662), Expect = 3e-68
Identities = 208/664 (31%), Positives = 317/664 (47%), Gaps = 50/664 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID--- 379
P FP +PEN + A DPD G G Y L +N +S+ F +D
Sbjct: 140 PMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNGQSV--FGLDIVE 194
Query: 380 -------PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPV 432
PQ + LDRE + + +++ +D G+P+ S+T ++ VTV+D ND+ PV
Sbjct: 195 TPEGEKWPQ---LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251
Query: 433 FEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRS 492
F++ Q + EN G ++QL ATD D NA +RY F A A F ++ +
Sbjct: 252 FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVA--PATKRLFALNNTT 309
Query: 493 GLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA 552
GLI+ +DRE +++ V ASD P ATV +++T D NDN P + ++
Sbjct: 310 GLITVQRSLDREETAIHKVTVLASDGSSTPA--RATVTINVT--DVNDNPPNIDLRYIIS 365
Query: 553 QVR------EDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
+ E +T + +T +D+D D NG V I A+ ++ +
Sbjct: 366 PINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS 425
Query: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPL 666
LD+E +E++ +I A D+G+P L N T L +++ D ND+ PIF ++SV EN
Sbjct: 426 LLDYEGTKEFSFKIVASDSGKPSL-NQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
Query: 667 GHSVIHIQAVDADHGENARLEYSLTGVAPDTPFV-INSATGWVSVSGPLDRESVEHYFFG 725
G + I A D D G+NA + Y L P+ F ++ TG ++ S DRE E + F
Sbjct: 485 GLYLTTISATDEDSGKNADIVYQL---GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA 785
V ARD+G+PPL + A+V VTVLD NDN P+FT + ++E+ ++V +T D DA
Sbjct: 542 VTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA 601
Query: 786 --NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHD 840
N A++ I N + F + GV + + D +Q+ + + A+D
Sbjct: 602 GENKAVTLSIL--NDNDNFVLDPYSGV--IKSNVSFDREQQSSYTFDVKATDGGQPPRSS 657
Query: 841 HCYVHINITDANTHRPVFQSAHYSVS---VNEDRPMGSTIVVISASDDDVGENARITYLL 897
V IN+ D N + PV S + S V GS + + A D D G NA + Y +
Sbjct: 658 TAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTI 717
Query: 898 --EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADT-TYVEVMVNDV 954
+N FRID +G ITL+ D + L + D G P+ T V + VND
Sbjct: 718 VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDT 777
Query: 955 NDNA 958
NA
Sbjct: 778 AGNA 781
Score = 233 bits (593), Expect = 3e-60
Identities = 194/668 (29%), Positives = 309/668 (46%), Gaps = 48/668 (7%)
Query: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL-TGVAPDT 697
I V D ND+ P+F S +S+ EN + A D D G N Y L G +
Sbjct: 130 IIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFG 189
Query: 698 PFVINSATG--W--VSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
++ + G W + V LDRE + Y ++ D G+P S++A + VTV DVNDNR
Sbjct: 190 LDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNR 249
Query: 754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGN----TRNRFAISTQ 807
P F + + + E+A VGTSV+ + A D D +N+ I Y I G T+ FA++
Sbjct: 250 PVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNT 308
Query: 808 GGVGLVTLALPLDYKQERYFKLVLTASD-RALHDHCYVHINITDANTHRP------VFQS 860
GL+T+ LD ++ K+ + ASD + V IN+TD N + P +
Sbjct: 309 --TGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISP 366
Query: 861 AHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDA---DSGAITLQA 917
+ +V ++E P+ + I +I+ SD D N ++ +E +P F + A + + +
Sbjct: 367 INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP-FHLKAVYDNQYLLETSS 425
Query: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
LDYE ++ I A D+G P T V V + D NDN P F VSE+
Sbjct: 426 LLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRG 485
Query: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
+ ISATD D+ N + Y Q G + F ++ +G++ R DRE + T
Sbjct: 486 LYLTTISATDEDSGKNADIVY--QLGPNASF-FDLDRKTGVLTASRVFDREEQERFIFTV 542
Query: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG 1097
A D G PPL++ ++ V V D NDN+P F F+ V EN S V IT D D G
Sbjct: 543 TARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAG 602
Query: 1098 PNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA---PLVSRAT 1154
N + I+ N + F +D +SG + + + D E + Y V+AT P S A
Sbjct: 603 ENKAVTLSILNDN--DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAK 660
Query: 1155 VHVRLVDQNDNSPVL------NNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD--VSDHL 1206
V + ++D NDNSPV+ +F+++ P ++ + A D D ++ L
Sbjct: 661 VTINVMDVNDNSPVVISPPSNTSFKLV-------PLSAIPGSVVAEVFAVDVDTGMNAEL 713
Query: 1207 FYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVII 1266
Y+ GN L ++ +G + L K + ++V ++D + + ++ V +
Sbjct: 714 KYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLY 773
Query: 1267 TEELLANS 1274
+ N+
Sbjct: 774 VNDTAGNA 781
Score = 197 bits (501), Expect = 1e-49
Identities = 176/654 (26%), Positives = 294/654 (44%), Gaps = 66/654 (10%)
Query: 662 ENAPLGH--SVIHIQAVDADHGENARLEYSLTGVAPDTPFV-INSATGWV-SVSGPLDRE 717
EN P+G+ ++I ++A G +A L Y L A D P V ++S+TG + + S +DRE
Sbjct: 36 ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95
Query: 718 SV---------EHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNED 768
+ FF +E + + + V D NDN P F ++ + E+
Sbjct: 96 KLCAGASYAEENECFFELEVVILPND-FFRLIKIKIIVKDTNDNAPMFPSPVINISIPEN 154
Query: 769 AAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAI-STQGGVGLVTLALP--LDYKQ 823
+ + +A D D N Y++ G + I T G L + LD +Q
Sbjct: 155 TLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQ 214
Query: 824 ERYFKLVLTASDRALHDH---CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVI 880
+ + + + D + + ++D N +RPVF+ V + E+ P+G++++ +
Sbjct: 215 KDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQL 274
Query: 881 SASDDDVGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITARD 935
A+D D+G NA I Y+ + F ++ +G IT+Q LD E+ + + + A D
Sbjct: 275 HATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD 334
Query: 936 -NGIPQKADTTYVEVMVNDVNDNAP----QFVASHYTGLV--SEDAPPFTSVLQISATDR 988
+ P +A T + V DVNDN P +++ S G V SE P T + I+ +D+
Sbjct: 335 GSSTPARATVT---INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDK 391
Query: 989 DAHANGRV------QYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDR 1042
D NG+V + F D + +E +S LD E + A D
Sbjct: 392 DTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS-------LLDYEGTKEFSFKIVASDS 444
Query: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
G P L ++V ++D NDN P+F E+ V EN+ G + I+A D D G NA I
Sbjct: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504
Query: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRL 1159
+YQ+ G F +D +G LTA D E ++ ++ V A + PL S+A V V +
Sbjct: 505 VYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTV 562
Query: 1160 VDQNDNSPVL--NNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
+D+NDNSP N+FQ + + S +G I D D ++ + N+
Sbjct: 563 LDENDNSPKFTHNHFQFFVSENLPKYS------TVGVITVTDADAGENKAVTLSILNDND 616
Query: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG---LHSVTAQCVLRVVIITE 1268
V++ SG ++ + D + + V TDG S TA+ + V+ + +
Sbjct: 617 NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVND 670
Score = 193 bits (491), Expect = 2e-48
Identities = 164/574 (28%), Positives = 250/574 (43%), Gaps = 34/574 (5%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ P F + + +PEN GT+V+++ A D D G + Y A + + LF+++
Sbjct: 247 DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP------VF 433
+GLI +LDRE H + V A D S AT V + V D ND+ P +
Sbjct: 307 NTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYII 364
Query: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSG 493
L E I + +D D N + F+ R +
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFI----EREVPFHLKAVYDNQY 419
Query: 494 LISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQ 553
L+ TS +D E + + + ASD G+ ++A VRV + DENDN P F++
Sbjct: 420 LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLE--DENDNPPIFNQPVIELS 477
Query: 554 VREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAE 613
V E+ R + ++ATD D N + Y + G + F +D TG + D E +
Sbjct: 478 VSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQ 535
Query: 614 REYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673
+ + A+D G PPL + + + V+D ND+ P F FQ V EN P +V I
Sbjct: 536 ERFIFTVTARDNGTPPLQSQAAVI-VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGS 733
DAD GEN + S+ + + FV++ +G + + DRE Y F V+A D G
Sbjct: 595 TVTDADAGENKAVTLSI--LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQ 652
Query: 734 PPLSASASVTVTVLDVNDNRPEFTMKEYHLRLN---EDAAVGTSVVSVTAVDRDA--NSA 788
PP S++A VT+ V+DVNDN P + A G+ V V AVD D N+
Sbjct: 653 PPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAE 712
Query: 789 ISYQITGGNTRNRFAIS-TQGGVGLVTLALPLDYKQERYFKLVLTASD----RALHDHCY 843
+ Y I GN + F I G + L P D R LV+ SD ++LH
Sbjct: 713 LKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR---LVVNISDLGYPKSLHTLVL 769
Query: 844 VHINITD-ANTHRPVFQSAHYSVSVNEDRPMGST 876
V + + D A ++ ++ DR +G +
Sbjct: 770 VFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDS 803
Score = 146 bits (368), Expect = 4e-34
Identities = 108/342 (31%), Positives = 158/342 (46%), Gaps = 23/342 (6%)
Query: 308 TSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAAL 367
T+ R + + P F Q + V EN G + + A D D+G+ +VY L
Sbjct: 452 TALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP- 510
Query: 368 MNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ F +D ++G++ + DRE ER VTA+D+G+P L + V VTV D N
Sbjct: 511 ----NASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDEN 566
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D+SP F ++ + EN+ + + + TD DA N + + F
Sbjct: 567 DNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILND-------NDNFV 619
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQF-- 545
+DP SG+I ++ DRE SY V+A+D GQ PRS+T +V I V+D NDN+P
Sbjct: 620 LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP--PRSSTAKVTINVMDVNDNSPVVIS 677
Query: 546 -SEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEI-- 602
V P +VV V A D D N + Y I+SGN++G F ID +TG I
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
Query: 603 -QVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVD 643
+ AP D R L + D G P + L + V D
Sbjct: 738 EEKPAPTDVGLHR---LVVNISDLGYPKSLHTLVLVFLYVND 776
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 323 bits (828), Expect = 2e-87
Identities = 241/743 (32%), Positives = 369/743 (49%), Gaps = 49/743 (6%)
Query: 418 MVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPI------LQLRATDGDAPPNANLRYR 471
++A +A S + ++ Y T+RE + E PI L + + +A+L YR
Sbjct: 8 LLAALIACLRLDSAIAQELIY--TIREELPENVPIGNIPKDLNISHINAATGTSASLVYR 65
Query: 472 FVGPPAARAAAAAAFEIDPRSG-LISTSGRVDREHMESYELVVEASDQGQE------PGP 524
V ++A A ++ +G + +TS R+DRE + + E ++ E P
Sbjct: 66 LV----SKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPND 121
Query: 525 RSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNI 584
+++ I V D NDNAP F + E+ ++ +ATD D NG+ HY +
Sbjct: 122 FFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL 181
Query: 585 ISGNSR-GHFAIDSLTGE----IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASI 639
++G S G +++ GE + V LD E + Y ++I+ +D G P S+ T + +
Sbjct: 182 LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSS-TAILQV 240
Query: 640 QVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTG-VAPDTP 698
V D+ND+ P+F +V + ENAP+G SVI + A DAD G NA + Y VAP T
Sbjct: 241 TVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATK 300
Query: 699 --FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEF 756
F +N+ TG ++V LDRE + V A D S P A A+VT+ V DVNDN P
Sbjct: 301 RLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP--ARATVTINVTDVNDNPPNI 358
Query: 757 TMKEY------HLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQG 808
++ + L+E V T + +T D+D N + I + A+
Sbjct: 359 DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ 418
Query: 809 GVGLVTLALPLDYKQERYFKLVLTASDR---ALHDHCYVHINITDANTHRPVFQSAHYSV 865
+ L T +L LDY+ + F + ASD +L+ V + + D N + P+F +
Sbjct: 419 YL-LETSSL-LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 866 SVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQV 925
SV+E+ G + ISA+D+D G+NA I Y L N F +D +G +T D E+Q
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQE 536
Query: 926 TYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISA 985
+ +TARDNG P V V V D NDN+P+F +H+ VSE+ P +++V I+
Sbjct: 537 RFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITV 596
Query: 986 TDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVP 1045
TD DA N V + N D +F ++P SG++++ DRE S Y A D G P
Sbjct: 597 TDADAGENKAVTLSILNDND---NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653
Query: 1046 PLRTPVSIQVMVQDVNDNAPVF---PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
P + + + V DVNDN+PV P+ V ++I GSVVA++ AVD D G NA +
Sbjct: 654 PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713
Query: 1103 MYQIVEGNIPELFQMDIFSGELT 1125
Y IV GN LF++D +G +T
Sbjct: 714 KYTIVSGNNKGLFRIDPVTGNIT 736
Score = 259 bits (662), Expect = 3e-68
Identities = 208/664 (31%), Positives = 317/664 (47%), Gaps = 50/664 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID--- 379
P FP +PEN + A DPD G G Y L +N +S+ F +D
Sbjct: 140 PMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNGQSV--FGLDIVE 194
Query: 380 -------PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPV 432
PQ + LDRE + + +++ +D G+P+ S+T ++ VTV+D ND+ PV
Sbjct: 195 TPEGEKWPQ---LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251
Query: 433 FEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRS 492
F++ Q + EN G ++QL ATD D NA +RY F A A F ++ +
Sbjct: 252 FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVA--PATKRLFALNNTT 309
Query: 493 GLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA 552
GLI+ +DRE +++ V ASD P ATV +++T D NDN P + ++
Sbjct: 310 GLITVQRSLDREETAIHKVTVLASDGSSTPA--RATVTINVT--DVNDNPPNIDLRYIIS 365
Query: 553 QVR------EDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
+ E +T + +T +D+D D NG V I A+ ++ +
Sbjct: 366 PINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS 425
Query: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPL 666
LD+E +E++ +I A D+G+P L N T L +++ D ND+ PIF ++SV EN
Sbjct: 426 LLDYEGTKEFSFKIVASDSGKPSL-NQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
Query: 667 GHSVIHIQAVDADHGENARLEYSLTGVAPDTPFV-INSATGWVSVSGPLDRESVEHYFFG 725
G + I A D D G+NA + Y L P+ F ++ TG ++ S DRE E + F
Sbjct: 485 GLYLTTISATDEDSGKNADIVYQL---GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA 785
V ARD+G+PPL + A+V VTVLD NDN P+FT + ++E+ ++V +T D DA
Sbjct: 542 VTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA 601
Query: 786 --NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHD 840
N A++ I N + F + GV + + D +Q+ + + A+D
Sbjct: 602 GENKAVTLSIL--NDNDNFVLDPYSGV--IKSNVSFDREQQSSYTFDVKATDGGQPPRSS 657
Query: 841 HCYVHINITDANTHRPVFQSAHYSVS---VNEDRPMGSTIVVISASDDDVGENARITYLL 897
V IN+ D N + PV S + S V GS + + A D D G NA + Y +
Sbjct: 658 TAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTI 717
Query: 898 --EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADT-TYVEVMVNDV 954
+N FRID +G ITL+ D + L + D G P+ T V + VND
Sbjct: 718 VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDT 777
Query: 955 NDNA 958
NA
Sbjct: 778 AGNA 781
Score = 233 bits (593), Expect = 3e-60
Identities = 194/668 (29%), Positives = 309/668 (46%), Gaps = 48/668 (7%)
Query: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL-TGVAPDT 697
I V D ND+ P+F S +S+ EN + A D D G N Y L G +
Sbjct: 130 IIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFG 189
Query: 698 PFVINSATG--W--VSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
++ + G W + V LDRE + Y ++ D G+P S++A + VTV DVNDNR
Sbjct: 190 LDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNR 249
Query: 754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGN----TRNRFAISTQ 807
P F + + + E+A VGTSV+ + A D D +N+ I Y I G T+ FA++
Sbjct: 250 PVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNT 308
Query: 808 GGVGLVTLALPLDYKQERYFKLVLTASD-RALHDHCYVHINITDANTHRP------VFQS 860
GL+T+ LD ++ K+ + ASD + V IN+TD N + P +
Sbjct: 309 --TGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISP 366
Query: 861 AHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDA---DSGAITLQA 917
+ +V ++E P+ + I +I+ SD D N ++ +E +P F + A + + +
Sbjct: 367 INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP-FHLKAVYDNQYLLETSS 425
Query: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
LDYE ++ I A D+G P T V V + D NDN P F VSE+
Sbjct: 426 LLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRG 485
Query: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
+ ISATD D+ N + Y Q G + F ++ +G++ R DRE + T
Sbjct: 486 LYLTTISATDEDSGKNADIVY--QLGPNASF-FDLDRKTGVLTASRVFDREEQERFIFTV 542
Query: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG 1097
A D G PPL++ ++ V V D NDN+P F F+ V EN S V IT D D G
Sbjct: 543 TARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAG 602
Query: 1098 PNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA---PLVSRAT 1154
N + I+ N + F +D +SG + + + D E + Y V+AT P S A
Sbjct: 603 ENKAVTLSILNDN--DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAK 660
Query: 1155 VHVRLVDQNDNSPVL------NNFQILFNNYVSNRSDTFPSGIIGRIPAYDPD--VSDHL 1206
V + ++D NDNSPV+ +F+++ P ++ + A D D ++ L
Sbjct: 661 VTINVMDVNDNSPVVISPPSNTSFKLV-------PLSAIPGSVVAEVFAVDVDTGMNAEL 713
Query: 1207 FYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVII 1266
Y+ GN L ++ +G + L K + ++V ++D + + ++ V +
Sbjct: 714 KYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLY 773
Query: 1267 TEELLANS 1274
+ N+
Sbjct: 774 VNDTAGNA 781
Score = 197 bits (501), Expect = 1e-49
Identities = 176/654 (26%), Positives = 294/654 (44%), Gaps = 66/654 (10%)
Query: 662 ENAPLGH--SVIHIQAVDADHGENARLEYSLTGVAPDTPFV-INSATGWV-SVSGPLDRE 717
EN P+G+ ++I ++A G +A L Y L A D P V ++S+TG + + S +DRE
Sbjct: 36 ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDRE 95
Query: 718 SV---------EHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNED 768
+ FF +E + + + V D NDN P F ++ + E+
Sbjct: 96 KLCAGASYAEENECFFELEVVILPND-FFRLIKIKIIVKDTNDNAPMFPSPVINISIPEN 154
Query: 769 AAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAI-STQGGVGLVTLALP--LDYKQ 823
+ + +A D D N Y++ G + I T G L + LD +Q
Sbjct: 155 TLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQ 214
Query: 824 ERYFKLVLTASDRALHDH---CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVI 880
+ + + + D + + ++D N +RPVF+ V + E+ P+G++++ +
Sbjct: 215 KDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQL 274
Query: 881 SASDDDVGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITARD 935
A+D D+G NA I Y+ + F ++ +G IT+Q LD E+ + + + A D
Sbjct: 275 HATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD 334
Query: 936 -NGIPQKADTTYVEVMVNDVNDNAP----QFVASHYTGLV--SEDAPPFTSVLQISATDR 988
+ P +A T + V DVNDN P +++ S G V SE P T + I+ +D+
Sbjct: 335 GSSTPARATVT---INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDK 391
Query: 989 DAHANGRV------QYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDR 1042
D NG+V + F D + +E +S LD E + A D
Sbjct: 392 DTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS-------LLDYEGTKEFSFKIVASDS 444
Query: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
G P L ++V ++D NDN P+F E+ V EN+ G + I+A D D G NA I
Sbjct: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504
Query: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRL 1159
+YQ+ G F +D +G LTA D E ++ ++ V A + PL S+A V V +
Sbjct: 505 VYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTV 562
Query: 1160 VDQNDNSPVL--NNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
+D+NDNSP N+FQ + + S +G I D D ++ + N+
Sbjct: 563 LDENDNSPKFTHNHFQFFVSENLPKYS------TVGVITVTDADAGENKAVTLSILNDND 616
Query: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG---LHSVTAQCVLRVVIITE 1268
V++ SG ++ + D + + V TDG S TA+ + V+ + +
Sbjct: 617 NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVND 670
Score = 193 bits (491), Expect = 2e-48
Identities = 164/574 (28%), Positives = 250/574 (43%), Gaps = 34/574 (5%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ P F + + +PEN GT+V+++ A D D G + Y A + + LF+++
Sbjct: 247 DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP------VF 433
+GLI +LDRE H + V A D S AT V + V D ND+ P +
Sbjct: 307 NTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYII 364
Query: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSG 493
L E I + +D D N + F+ R +
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFI----EREVPFHLKAVYDNQY 419
Query: 494 LISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQ 553
L+ TS +D E + + + ASD G+ ++A VRV + DENDN P F++
Sbjct: 420 LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLE--DENDNPPIFNQPVIELS 477
Query: 554 VREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAE 613
V E+ R + ++ATD D N + Y + G + F +D TG + D E +
Sbjct: 478 VSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQ 535
Query: 614 REYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673
+ + A+D G PPL + + + V+D ND+ P F FQ V EN P +V I
Sbjct: 536 ERFIFTVTARDNGTPPLQSQAAVI-VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGS 733
DAD GEN + S+ + + FV++ +G + + DRE Y F V+A D G
Sbjct: 595 TVTDADAGENKAVTLSI--LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQ 652
Query: 734 PPLSASASVTVTVLDVNDNRPEFTMKEYHLRLN---EDAAVGTSVVSVTAVDRDA--NSA 788
PP S++A VT+ V+DVNDN P + A G+ V V AVD D N+
Sbjct: 653 PPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAE 712
Query: 789 ISYQITGGNTRNRFAIS-TQGGVGLVTLALPLDYKQERYFKLVLTASD----RALHDHCY 843
+ Y I GN + F I G + L P D R LV+ SD ++LH
Sbjct: 713 LKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR---LVVNISDLGYPKSLHTLVL 769
Query: 844 VHINITD-ANTHRPVFQSAHYSVSVNEDRPMGST 876
V + + D A ++ ++ DR +G +
Sbjct: 770 VFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDS 803
Score = 146 bits (368), Expect = 4e-34
Identities = 108/342 (31%), Positives = 158/342 (46%), Gaps = 23/342 (6%)
Query: 308 TSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAAL 367
T+ R + + P F Q + V EN G + + A D D+G+ +VY L
Sbjct: 452 TALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP- 510
Query: 368 MNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ F +D ++G++ + DRE ER VTA+D+G+P L + V VTV D N
Sbjct: 511 ----NASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDEN 566
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D+SP F ++ + EN+ + + + TD DA N + + F
Sbjct: 567 DNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILND-------NDNFV 619
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQF-- 545
+DP SG+I ++ DRE SY V+A+D GQ PRS+T +V I V+D NDN+P
Sbjct: 620 LDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP--PRSSTAKVTINVMDVNDNSPVVIS 677
Query: 546 -SEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEI-- 602
V P +VV V A D D N + Y I+SGN++G F ID +TG I
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
Query: 603 -QVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVD 643
+ AP D R L + D G P + L + V D
Sbjct: 738 EEKPAPTDVGLHR---LVVNISDLGYPKSLHTLVLVFLYVND 776
>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
Length = 1237
Score = 298 bits (763), Expect = 6e-80
Identities = 217/666 (32%), Positives = 316/666 (47%), Gaps = 44/666 (6%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI---- 378
P F +PEN G+ +A D DAG G Y L A + ELF +
Sbjct: 166 PNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQA--GPEAQELFGLQVAE 223
Query: 379 ---DPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
+ Q LI LDRE + + L + QD GSP +++ ++ VTV D ND++P FE+
Sbjct: 224 DQEEKQPQLI-VMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFER 282
Query: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Y L EN G+ ++Q++A D D NA + Y F P +D +GLI
Sbjct: 283 PSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAP---EVVRRLLRLDRNTGLI 339
Query: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQF--------SE 547
+ G VDRE + + V A D+G P+SA +V +TV D NDNAP +
Sbjct: 340 TVQGPVDREDLSTLRFSVLAKDRG--TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTH 397
Query: 548 KRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGE------ 601
+ +A + EDV T V V +DRD+ N V +++G+ S TG
Sbjct: 398 QDGMANISEDVAEETAVALVQVSDRDEGENAAVTC-VVAGDVPFQLRQASETGSDSKKKY 456
Query: 602 -IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSV 660
+Q PLD+E ++Y + I A D+G PPLS+ L +QVVD+ND+ P+F + +V+
Sbjct: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSL-KVQVVDVNDNAPVFTQSVTEVAF 515
Query: 661 LENAPLGHSVIHIQAVDADHGENARLEYSL-TGVAPDTPFVINSATGWVSVSGPLDRESV 719
EN G + I A DAD G NA L YSL A F I+ TG + V LDRE
Sbjct: 516 PENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQR 575
Query: 720 EHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVT 779
E Y V A D GSP L +A+V V VLD NDN P+F + Y+ + E+ + V VT
Sbjct: 576 ESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVT 635
Query: 780 AVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRAL- 838
+D D Q++ F I Q G G + +L D +Q+ + L A D +
Sbjct: 636 VIDGDKGENAQVQLSVEQDNGDFVI--QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVP 693
Query: 839 --HDHCYVHINITDANTHRPVF---QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARI 893
+ V IN+ D N + P + + + + R +G T+ ++A D D G NA +
Sbjct: 694 PRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTR-LGETVSQVAAEDFDSGVNAEL 752
Query: 894 TYLLEDNLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMV 951
Y + P F+I + SGAITL+ ++ + L + D G P + T V + V
Sbjct: 753 IYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Query: 952 NDVNDN 957
N+ N
Sbjct: 813 NETLAN 818
Score = 296 bits (758), Expect = 2e-79
Identities = 230/772 (29%), Positives = 358/772 (46%), Gaps = 79/772 (10%)
Query: 461 DAPPN-------ANLRYRFVGPPAARAAAAAAFEIDPRSG-LISTSGRVDREHMES---- 508
+ PPN A+ + VG A +D ++G + +T +DRE +
Sbjct: 67 EQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQ 126
Query: 509 -------YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561
E V +D Q PR + I V D NDN P F+ + E+
Sbjct: 127 LPGDPCILEFEVSITDLVQNGSPR--LLEGQIEVQDINDNTPNFASPVITLAIPENTNIG 184
Query: 562 TVVLRVTATDRDKDANGLVHYNIISG-NSRGHFAI------DSLTGEIQVVAPLDFEAER 614
++ A+DRD NG+ Y + +G ++ F + + ++ V+ LD E
Sbjct: 185 SLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWD 244
Query: 615 EYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQ 674
Y L I+ QD G PP + ++ L + V+D ND+ P F ++ + EN+P+GHSVI ++
Sbjct: 245 SYDLTIKVQDGGSPPRA-SSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVK 303
Query: 675 AVDADHGENARLEYSLTGVAPDTP---FVINSATGWVSVSGPLDRESVEHYFFGVEARDH 731
A D+D G NA +EY+ AP+ ++ TG ++V GP+DRE + F V A+D
Sbjct: 304 ANDSDQGANAEIEYTF-HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDR 362
Query: 732 GSPPLSASASVTVTVLDVNDNRPEFTMKEYHL--------RLNEDAAVGTSVVSVTAVDR 783
G+ P SA A V VTV D+NDN P ++ L ++ED A T+V V DR
Sbjct: 363 GTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDR 422
Query: 784 D--ANSAISYQI-------------TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFK 828
D N+A++ + TG +++ ++ + T PLDY++ + +
Sbjct: 423 DEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQT---------TTPLDYEKVKDYT 473
Query: 829 LVLTASDRA---LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDD 885
+ + A D L + + + D N + PVF + V+ E+ G I I+ASD
Sbjct: 474 IEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDA 533
Query: 886 DVGENARITYLLEDNLPQ---FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKA 942
D G NA + Y LE F I ++G I ++ LD E + +Y L + A D G P
Sbjct: 534 DSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQ 593
Query: 943 DTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQN 1002
T V V V D NDN P+F+ S Y V E+ P + V ++ D D N +VQ +
Sbjct: 594 GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV-- 651
Query: 1003 GEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVND 1062
E +GDF I+ +G + + DRE S Y AVD GVPP V + + V D ND
Sbjct: 652 -EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDEND 710
Query: 1063 NAPVF--PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIF 1120
NAP P+ + + +G V+Q+ A D D G NA ++Y I GN LFQ+
Sbjct: 711 NAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSH 770
Query: 1121 SGELTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNSPVL 1169
SG +T +++ + +VV+ + P A VH+ + + N +L
Sbjct: 771 SGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLL 822
Score = 256 bits (655), Expect = 2e-67
Identities = 207/750 (27%), Positives = 334/750 (44%), Gaps = 60/750 (8%)
Query: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVV-AP 607
R V +V E+ P+T++ + A D L + + +D TG+I
Sbjct: 59 RVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEV----GAPYLRVDGKTGDIFTTETS 114
Query: 608 LDFEAEREYALRIRAQDA--------------GRPPLSNNTGLASIQVVDINDHIPIFVS 653
+D E RE ++ G P L I+V DIND+ P F S
Sbjct: 115 IDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG----QIEVQDINDNTPNFAS 170
Query: 654 TPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL-TGVAPDTPFVINSATGW----- 707
+++ EN +G A D D G N Y L G F + A
Sbjct: 171 PVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQP 230
Query: 708 -VSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLN 766
+ V G LDRE + Y ++ +D GSPP ++SA + VTVLD NDN P+F Y L+
Sbjct: 231 QLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELS 290
Query: 767 EDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQE 824
E++ +G SV+ V A D D AN+ I Y R + GL+T+ P+D +
Sbjct: 291 ENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDL 350
Query: 825 RYFKLVLTASDRALHD---HCYVHINITDANTHRPVFQSAHYSV--------SVNEDRPM 873
+ + A DR + V + + D N + P + + +++ED
Sbjct: 351 STLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE 410
Query: 874 GSTIVVISASDDDVGENARITYLLEDNLP-QFRIDADSGA-------ITLQAPLDYEDQV 925
+ + ++ SD D GENA +T ++ ++P Q R +++G+ + PLDYE
Sbjct: 411 ETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVK 470
Query: 926 TYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISA 985
YT+ I A D+G P + T ++V V DVNDNAP F S E+ P + +I+A
Sbjct: 471 DYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITA 530
Query: 986 TDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVP 1045
+D D+ +N + Y+ + G FTI P +G ++ LDRE YEL A DRG P
Sbjct: 531 SDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSP 590
Query: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQ 1105
L+ ++ V V D NDN P F + V EN S V +T +D D+G NA +
Sbjct: 591 SLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLS 650
Query: 1106 IVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSRAT---VHVRLVDQ 1162
+ + N + Q +G + + + D E + Y ++A + R+ V + ++D+
Sbjct: 651 VEQDNGDFVIQNG--TGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDE 708
Query: 1163 NDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPA--YDPDVSDHLFYSFERGNELQLLV 1220
NDN+P + + ++ T + ++ A +D V+ L YS GN L
Sbjct: 709 NDNAPYITAPSNTSHKLLT--PQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQ 766
Query: 1221 VNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
+ SG + L ++++ + ++V V+D
Sbjct: 767 IGSHSGAITLEKEIERRHHGLHRLVVKVSD 796
Score = 186 bits (471), Expect = 4e-46
Identities = 141/426 (33%), Positives = 206/426 (48%), Gaps = 16/426 (3%)
Query: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAA---LMNSRSLELFSIDPQSGLIRTAAA 390
+ E+ A TAV V D D GE + +A ++ E S + ++T
Sbjct: 404 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTP 463
Query: 391 LDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGY 450
LD E ++ + + + A D G+P LS+T + V V D ND++PVF Q+ EN + G
Sbjct: 464 LDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGE 523
Query: 451 PILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYE 510
I ++ A+D D+ NA L Y PAA+ F I P +G I +DRE ESYE
Sbjct: 524 VIAEITASDADSGSNAELVYSLEPEPAAKGL----FTISPETGEIQVKTSLDREQRESYE 579
Query: 511 LVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTAT 570
L V A+D+G +ATV V+ VLD NDN P+F Y V E++ + V VT
Sbjct: 580 LKVVAADRGSPSLQGTATVLVN--VLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVI 637
Query: 571 DRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPL 630
D DK N V ++ N G F I + TG I D E + Y +++A D G PP
Sbjct: 638 DGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPR 695
Query: 631 SNNTGLASIQVVDINDHIPIFVSTPFQVS---VLENAPLGHSVIHIQAVDADHGENARLE 687
S G+ +I V+D ND+ P +++ P S + LG +V + A D D G NA L
Sbjct: 696 SAYVGV-TINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI 753
Query: 688 YSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVL 747
YS+ G P F I S +G +++ ++R + V+ D G PP +A V + V
Sbjct: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVN 813
Query: 748 DVNDNR 753
+ NR
Sbjct: 814 ETLANR 819
>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
Length = 1060
Score = 298 bits (763), Expect = 6e-80
Identities = 217/666 (32%), Positives = 316/666 (47%), Gaps = 44/666 (6%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI---- 378
P F +PEN G+ +A D DAG G Y L A + ELF +
Sbjct: 166 PNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQA--GPEAQELFGLQVAE 223
Query: 379 ---DPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
+ Q LI LDRE + + L + QD GSP +++ ++ VTV D ND++P FE+
Sbjct: 224 DQEEKQPQLI-VMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFER 282
Query: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Y L EN G+ ++Q++A D D NA + Y F P +D +GLI
Sbjct: 283 PSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAP---EVVRRLLRLDRNTGLI 339
Query: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQF--------SE 547
+ G VDRE + + V A D+G P+SA +V +TV D NDNAP +
Sbjct: 340 TVQGPVDREDLSTLRFSVLAKDRG--TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTH 397
Query: 548 KRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGE------ 601
+ +A + EDV T V V +DRD+ N V +++G+ S TG
Sbjct: 398 QDGMANISEDVAEETAVALVQVSDRDEGENAAVTC-VVAGDVPFQLRQASETGSDSKKKY 456
Query: 602 -IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSV 660
+Q PLD+E ++Y + I A D+G PPLS+ L +QVVD+ND+ P+F + +V+
Sbjct: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSL-KVQVVDVNDNAPVFTQSVTEVAF 515
Query: 661 LENAPLGHSVIHIQAVDADHGENARLEYSL-TGVAPDTPFVINSATGWVSVSGPLDRESV 719
EN G + I A DAD G NA L YSL A F I+ TG + V LDRE
Sbjct: 516 PENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQR 575
Query: 720 EHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVT 779
E Y V A D GSP L +A+V V VLD NDN P+F + Y+ + E+ + V VT
Sbjct: 576 ESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVT 635
Query: 780 AVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRAL- 838
+D D Q++ F I Q G G + +L D +Q+ + L A D +
Sbjct: 636 VIDGDKGENAQVQLSVEQDNGDFVI--QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVP 693
Query: 839 --HDHCYVHINITDANTHRPVF---QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARI 893
+ V IN+ D N + P + + + + R +G T+ ++A D D G NA +
Sbjct: 694 PRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTR-LGETVSQVAAEDFDSGVNAEL 752
Query: 894 TYLLEDNLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMV 951
Y + P F+I + SGAITL+ ++ + L + D G P + T V + V
Sbjct: 753 IYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Query: 952 NDVNDN 957
N+ N
Sbjct: 813 NETLAN 818
Score = 296 bits (758), Expect = 2e-79
Identities = 230/772 (29%), Positives = 358/772 (46%), Gaps = 79/772 (10%)
Query: 461 DAPPN-------ANLRYRFVGPPAARAAAAAAFEIDPRSG-LISTSGRVDREHMES---- 508
+ PPN A+ + VG A +D ++G + +T +DRE +
Sbjct: 67 EQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQ 126
Query: 509 -------YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561
E V +D Q PR + I V D NDN P F+ + E+
Sbjct: 127 LPGDPCILEFEVSITDLVQNGSPR--LLEGQIEVQDINDNTPNFASPVITLAIPENTNIG 184
Query: 562 TVVLRVTATDRDKDANGLVHYNIISG-NSRGHFAI------DSLTGEIQVVAPLDFEAER 614
++ A+DRD NG+ Y + +G ++ F + + ++ V+ LD E
Sbjct: 185 SLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWD 244
Query: 615 EYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQ 674
Y L I+ QD G PP + ++ L + V+D ND+ P F ++ + EN+P+GHSVI ++
Sbjct: 245 SYDLTIKVQDGGSPPRA-SSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVK 303
Query: 675 AVDADHGENARLEYSLTGVAPDTP---FVINSATGWVSVSGPLDRESVEHYFFGVEARDH 731
A D+D G NA +EY+ AP+ ++ TG ++V GP+DRE + F V A+D
Sbjct: 304 ANDSDQGANAEIEYTF-HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDR 362
Query: 732 GSPPLSASASVTVTVLDVNDNRPEFTMKEYHL--------RLNEDAAVGTSVVSVTAVDR 783
G+ P SA A V VTV D+NDN P ++ L ++ED A T+V V DR
Sbjct: 363 GTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDR 422
Query: 784 D--ANSAISYQI-------------TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFK 828
D N+A++ + TG +++ ++ + T PLDY++ + +
Sbjct: 423 DEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQT---------TTPLDYEKVKDYT 473
Query: 829 LVLTASDRA---LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDD 885
+ + A D L + + + D N + PVF + V+ E+ G I I+ASD
Sbjct: 474 IEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDA 533
Query: 886 DVGENARITYLLEDNLPQ---FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKA 942
D G NA + Y LE F I ++G I ++ LD E + +Y L + A D G P
Sbjct: 534 DSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQ 593
Query: 943 DTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQN 1002
T V V V D NDN P+F+ S Y V E+ P + V ++ D D N +VQ +
Sbjct: 594 GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV-- 651
Query: 1003 GEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVND 1062
E +GDF I+ +G + + DRE S Y AVD GVPP V + + V D ND
Sbjct: 652 -EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDEND 710
Query: 1063 NAPVF--PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIF 1120
NAP P+ + + +G V+Q+ A D D G NA ++Y I GN LFQ+
Sbjct: 711 NAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSH 770
Query: 1121 SGELTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNSPVL 1169
SG +T +++ + +VV+ + P A VH+ + + N +L
Sbjct: 771 SGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLL 822
Score = 256 bits (655), Expect = 2e-67
Identities = 207/750 (27%), Positives = 334/750 (44%), Gaps = 60/750 (8%)
Query: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVV-AP 607
R V +V E+ P+T++ + A D L + + +D TG+I
Sbjct: 59 RVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEV----GAPYLRVDGKTGDIFTTETS 114
Query: 608 LDFEAEREYALRIRAQDA--------------GRPPLSNNTGLASIQVVDINDHIPIFVS 653
+D E RE ++ G P L I+V DIND+ P F S
Sbjct: 115 IDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG----QIEVQDINDNTPNFAS 170
Query: 654 TPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL-TGVAPDTPFVINSATGW----- 707
+++ EN +G A D D G N Y L G F + A
Sbjct: 171 PVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQP 230
Query: 708 -VSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLN 766
+ V G LDRE + Y ++ +D GSPP ++SA + VTVLD NDN P+F Y L+
Sbjct: 231 QLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELS 290
Query: 767 EDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQE 824
E++ +G SV+ V A D D AN+ I Y R + GL+T+ P+D +
Sbjct: 291 ENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDL 350
Query: 825 RYFKLVLTASDRALHD---HCYVHINITDANTHRPVFQSAHYSV--------SVNEDRPM 873
+ + A DR + V + + D N + P + + +++ED
Sbjct: 351 STLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAE 410
Query: 874 GSTIVVISASDDDVGENARITYLLEDNLP-QFRIDADSGA-------ITLQAPLDYEDQV 925
+ + ++ SD D GENA +T ++ ++P Q R +++G+ + PLDYE
Sbjct: 411 ETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVK 470
Query: 926 TYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISA 985
YT+ I A D+G P + T ++V V DVNDNAP F S E+ P + +I+A
Sbjct: 471 DYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITA 530
Query: 986 TDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVP 1045
+D D+ +N + Y+ + G FTI P +G ++ LDRE YEL A DRG P
Sbjct: 531 SDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSP 590
Query: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQ 1105
L+ ++ V V D NDN P F + V EN S V +T +D D+G NA +
Sbjct: 591 SLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLS 650
Query: 1106 IVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSRAT---VHVRLVDQ 1162
+ + N + Q +G + + + D E + Y ++A + R+ V + ++D+
Sbjct: 651 VEQDNGDFVIQNG--TGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDE 708
Query: 1163 NDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPA--YDPDVSDHLFYSFERGNELQLLV 1220
NDN+P + + ++ T + ++ A +D V+ L YS GN L
Sbjct: 709 NDNAPYITAPSNTSHKLLT--PQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQ 766
Query: 1221 VNQTSGELRLSRKLDNNRPLVASMLVTVTD 1250
+ SG + L ++++ + ++V V+D
Sbjct: 767 IGSHSGAITLEKEIERRHHGLHRLVVKVSD 796
Score = 186 bits (471), Expect = 4e-46
Identities = 141/426 (33%), Positives = 206/426 (48%), Gaps = 16/426 (3%)
Query: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAA---LMNSRSLELFSIDPQSGLIRTAAA 390
+ E+ A TAV V D D GE + +A ++ E S + ++T
Sbjct: 404 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTP 463
Query: 391 LDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGY 450
LD E ++ + + + A D G+P LS+T + V V D ND++PVF Q+ EN + G
Sbjct: 464 LDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGE 523
Query: 451 PILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYE 510
I ++ A+D D+ NA L Y PAA+ F I P +G I +DRE ESYE
Sbjct: 524 VIAEITASDADSGSNAELVYSLEPEPAAKGL----FTISPETGEIQVKTSLDREQRESYE 579
Query: 511 LVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTAT 570
L V A+D+G +ATV V+ VLD NDN P+F Y V E++ + V VT
Sbjct: 580 LKVVAADRGSPSLQGTATVLVN--VLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVI 637
Query: 571 DRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPL 630
D DK N V ++ N G F I + TG I D E + Y +++A D G PP
Sbjct: 638 DGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPR 695
Query: 631 SNNTGLASIQVVDINDHIPIFVSTPFQVS---VLENAPLGHSVIHIQAVDADHGENARLE 687
S G+ +I V+D ND+ P +++ P S + LG +V + A D D G NA L
Sbjct: 696 SAYVGV-TINVLDENDNAP-YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI 753
Query: 688 YSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVL 747
YS+ G P F I S +G +++ ++R + V+ D G PP +A V + V
Sbjct: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVN 813
Query: 748 DVNDNR 753
+ NR
Sbjct: 814 ETLANR 819
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 291 bits (746), Expect = 6e-78
Identities = 250/817 (30%), Positives = 379/817 (46%), Gaps = 75/817 (9%)
Query: 413 LSATTMVAVTVADRNDHSPVFEQAQ-YRETLRENVEEGYPILQLRATDGDAPPNANLRYR 471
LS T + AV +A HS E+ RE + ENV G + L + PN +L
Sbjct: 4 LSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLS---LIPNKSLTTA 60
Query: 472 FVGPPAARAAAAAAFEIDPRSGLISTSG-RVDREHMES---------YELVVEASDQGQE 521
+ I+ +G I T+G R+DRE + + YE+ V
Sbjct: 61 MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 115
Query: 522 PGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVH 581
P V++ + D NDNAP F + E+ ++ A D D NG+ +
Sbjct: 116 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 582 YNII-SGNSRGHFAIDSLTG----EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGL 636
Y +I S N G I++ G ++ V LD E + Y ++++ +D G P S +T +
Sbjct: 176 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRS-STAI 234
Query: 637 ASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPD 696
+ V D ND+ P+F T +VS+ ENAP+G SV + A DAD GENA++ +S + + +
Sbjct: 235 LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 294
Query: 697 TP---FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
F +N+ TG +++ PLDRE ++ V A D G P A A V V V DVNDN
Sbjct: 295 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNV 352
Query: 754 PEFTMK------EYHLRLNEDAAVGTSVVSVTAVDRDA--NSAIS----YQITGGNTRNR 801
P ++ + L+E+ + T + +T D+DA N ++ ++I R R
Sbjct: 353 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRLR 409
Query: 802 FAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVF 858
S Q L+ A LDY+ + + + L A+D L+ + I + D N + PVF
Sbjct: 410 PVFSNQ---FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF 466
Query: 859 QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL-EDNLPQFRIDADSGAITLQA 917
+ +VS+ E+ G + +SA D D G NA+I YLL D P+F +D +G +T+
Sbjct: 467 TQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK 526
Query: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
LD E + Y I A+DNG+P V V + D NDN+P F + Y V E+ P
Sbjct: 527 KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRH 586
Query: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
+V I+ TD D N V + + D DFTI+ +G++R DRE Y
Sbjct: 587 GTVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYV 643
Query: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVF---PAEEFEVRVKENSIVGSVVAQITAVDP 1094
A D G + + + V DVNDN PVF P+ V ++ G+VV Q+ AVD
Sbjct: 644 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDN 703
Query: 1095 DEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL-----------------IDLDYEARQE 1137
D G NA + Y IV GN +LF +D +G +T + DL
Sbjct: 704 DTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 763
Query: 1138 YVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQI 1174
V++V V+ AT+ LV ++ +PV N +I
Sbjct: 764 SVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEI 800
Score = 284 bits (727), Expect = 9e-76
Identities = 217/696 (31%), Positives = 342/696 (49%), Gaps = 52/696 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI---D 379
P FP +PEN A + A DPD G G Y L N L++ D
Sbjct: 137 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 196
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
LI LDRE + + ++V +D G P+ S+T ++ V+V D ND+ PVF++ +
Sbjct: 197 KMPQLI-VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
++ EN G + QL ATD D NA + + F A F ++ +GLI+
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN--LVSNIARRLFHLNATTGLITIKE 313
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQ------ 553
+DRE +++L+V ASD G P A V + V D NDN P + RY+
Sbjct: 314 PLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNPVNDTV 368
Query: 554 -VREDVRPHTVVLRVTATDRDKDANGLVHY---NIISGNSRGHFAIDSLTGEIQVVAPLD 609
+ E++ +T + +T TD+D D NG V + I R F+ L ++ A LD
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL---LETAAYLD 425
Query: 610 FEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
+E+ +EYA+++ A DAG+PPL N + + I+V D ND+ P+F + VS+ EN G
Sbjct: 426 YESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 484
Query: 670 VIHIQAVDADHGENARLEYSLTGVAPDTP--FVINSATGWVSVSGPLDRESVEHYFFGVE 727
+ + A+DAD G NA++ Y L PD P F ++ TG ++V LDRE + Y F +
Sbjct: 485 LTKVSAMDADSGPNAKINYLL---GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTIL 541
Query: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--A 785
A+D+G PPL+++ +V V+++D NDN P FT EY+ + E+ +V +T D D
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR---ALHDHC 842
NSA++ I N + F I +Q GV + + D +++ + + A D +
Sbjct: 602 NSAVTLSILDEN--DDFTIDSQTGV--IRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 843 YVHINITDANTHRPVF----QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL- 897
V IN+ D N ++PVF + Y + + P G+ + + A D+D G NA + Y +
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIV 716
Query: 898 -EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVN-DVN 955
+ F ID ++G ITL D D + + + A D G P D+ + V+VN VN
Sbjct: 717 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP---DSLFSVVIVNLFVN 773
Query: 956 DNAPQFVASHYTGLVSEDAP--PFTSVLQISATDRD 989
++ + S +AP P T + +S+ D
Sbjct: 774 ESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 266 bits (681), Expect = 2e-70
Identities = 205/667 (30%), Positives = 314/667 (47%), Gaps = 42/667 (6%)
Query: 641 VVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPF- 699
+ DIND+ P+F +T +S+ EN+ + AVD D G N Y L + F
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL--IKSQNIFG 186
Query: 700 --VINSATG----WVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
VI + G + V LDRE + Y V+ D G P S++A + V+V D NDN
Sbjct: 187 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFA---ISTQGGV 810
P F E + + E+A VGTSV + A D D + N + A
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306
Query: 811 GLVTLALPLDYKQERYFKLVLTASDRALHD-HCYVHINITDANTHRP------VFQSAHY 863
GL+T+ PLD ++ KL++ ASD L V +N+TD N + P + +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRID---ADSGAITLQAPLD 920
+V ++E+ P+ + I +I+ +D D N R+T + +P FR+ ++ + A LD
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLLETAAYLD 425
Query: 921 YEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSV 980
YE Y + + A D G P + + + V D NDNAP F S T + E+ P +
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 981 LQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV 1040
++SA D D+ N ++ Y G D +F+++ +G++ V++LDRE Y T A
Sbjct: 486 TKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 1041 DRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNA 1100
D GVPPL + V++ V + D NDN+PVF E+ V EN V IT DPD G N+
Sbjct: 544 DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1101 HIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHV 1157
+ I++ N + F +D +G + I D E ++ Y V+A VSR A V +
Sbjct: 604 AVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 1158 RLVDQNDNSPVLNNFQILFNN--YVSNRSDTFPSGIIGRIPAYDPD--VSDHLFYSFERG 1213
+VD NDN PV F + +N Y T P ++ ++ A D D ++ + YS G
Sbjct: 662 NVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 718
Query: 1214 NELQLLVVNQTSGELRLSRKLD-----NNRPLVASMLVTVTDGLHSVTAQCVLRVVIITE 1268
N L ++Q +G + L K D +R LV + + D L SV + +T
Sbjct: 719 NTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTN 778
Query: 1269 ELLANSL 1275
L N L
Sbjct: 779 ATLINEL 785
Score = 236 bits (603), Expect = 2e-61
Identities = 174/539 (32%), Positives = 260/539 (48%), Gaps = 34/539 (6%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ HP F + + +PEN GT+V ++ A D D GE ++ +S + L+++ + LF ++
Sbjct: 244 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP------VF 433
+GLI LDRE H L V A D G + A MV V V D ND+ P +
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIV 361
Query: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDP--- 490
L EN+ I + TD DA N G F + P
Sbjct: 362 NPVNDTVVLSENIPLNTKIALITVTDKDADHN--------GRVTCFTDHEIPFRLRPVFS 413
Query: 491 RSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRY 550
L+ T+ +D E + Y + + A+D G+ P +SA + I V DENDNAP F++
Sbjct: 414 NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSA--MLFIKVKDENDNAPVFTQSFV 471
Query: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
+ E+ P + +V+A D D N ++Y ++ ++ F++D TG + VV LD
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDR 530
Query: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
E E +Y I A+D G PPL++N + ++D ND+ P+F + V EN P +V
Sbjct: 531 EKEDKYLFTILAKDNGVPPLTSNV-TVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
I D D+G+N+ + S+ D F I+S TG + + DRE E Y F V+A D
Sbjct: 590 GLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAED 647
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMK----EYHLRLNEDAAVGTSVVSVTAVDRDA- 785
G S+SA VT+ V+DVNDN+P F + Y L L GT V V AVD D
Sbjct: 648 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL-PSTNPGTVVFQVIAVDNDTG 706
Query: 786 -NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY 843
N+ + Y I GGNTR+ FAI + G +TL D ++++ A+D D +
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQE--TGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 763
Score = 84.3 bits (207), Expect = 2e-15
Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 27/260 (10%)
Query: 1013 EPTSGIVRTVRRLDREAVSVY----ELTAYAVDRGVPP--LRTPVSIQVMVQDVNDNAPV 1066
E T I T R+DRE + E Y V+ + P + V I+ +++D+NDNAP+
Sbjct: 79 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 1067 FPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFS----- 1121
FPA + + ENS + S AVDPD G N Y++++ +F +D+
Sbjct: 139 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQ--NIFGLDVIETPEGD 196
Query: 1122 --GELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHVRLVDQNDNSPVLNNFQILF 1176
+L +LD E + YV+ V+ R A + V + D NDN PV +I
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-- 254
Query: 1177 NNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNEL-----QLLVVNQTSGELRLS 1231
VS + + ++ A D D+ ++ F N + +L +N T+G + +
Sbjct: 255 --EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312
Query: 1232 RKLDNNRPLVASMLVTVTDG 1251
LD +LV +DG
Sbjct: 313 EPLDREETPNHKLLVLASDG 332
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 291 bits (746), Expect = 6e-78
Identities = 250/817 (30%), Positives = 379/817 (46%), Gaps = 75/817 (9%)
Query: 413 LSATTMVAVTVADRNDHSPVFEQAQ-YRETLRENVEEGYPILQLRATDGDAPPNANLRYR 471
LS T + AV +A HS E+ RE + ENV G + L + PN +L
Sbjct: 4 LSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLS---LIPNKSLTTA 60
Query: 472 FVGPPAARAAAAAAFEIDPRSGLISTSG-RVDREHMES---------YELVVEASDQGQE 521
+ I+ +G I T+G R+DRE + + YE+ V
Sbjct: 61 MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 115
Query: 522 PGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVH 581
P V++ + D NDNAP F + E+ ++ A D D NG+ +
Sbjct: 116 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 582 YNII-SGNSRGHFAIDSLTG----EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGL 636
Y +I S N G I++ G ++ V LD E + Y ++++ +D G P S +T +
Sbjct: 176 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRS-STAI 234
Query: 637 ASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPD 696
+ V D ND+ P+F T +VS+ ENAP+G SV + A DAD GENA++ +S + + +
Sbjct: 235 LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 294
Query: 697 TP---FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
F +N+ TG +++ PLDRE ++ V A D G P A A V V V DVNDN
Sbjct: 295 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNV 352
Query: 754 PEFTMK------EYHLRLNEDAAVGTSVVSVTAVDRDA--NSAIS----YQITGGNTRNR 801
P ++ + L+E+ + T + +T D+DA N ++ ++I R R
Sbjct: 353 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRLR 409
Query: 802 FAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVF 858
S Q L+ A LDY+ + + + L A+D L+ + I + D N + PVF
Sbjct: 410 PVFSNQ---FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF 466
Query: 859 QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL-EDNLPQFRIDADSGAITLQA 917
+ +VS+ E+ G + +SA D D G NA+I YLL D P+F +D +G +T+
Sbjct: 467 TQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK 526
Query: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
LD E + Y I A+DNG+P V V + D NDN+P F + Y V E+ P
Sbjct: 527 KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRH 586
Query: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
+V I+ TD D N V + + D DFTI+ +G++R DRE Y
Sbjct: 587 GTVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYV 643
Query: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVF---PAEEFEVRVKENSIVGSVVAQITAVDP 1094
A D G + + + V DVNDN PVF P+ V ++ G+VV Q+ AVD
Sbjct: 644 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDN 703
Query: 1095 DEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL-----------------IDLDYEARQE 1137
D G NA + Y IV GN +LF +D +G +T + DL
Sbjct: 704 DTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 763
Query: 1138 YVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQI 1174
V++V V+ AT+ LV ++ +PV N +I
Sbjct: 764 SVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEI 800
Score = 284 bits (727), Expect = 9e-76
Identities = 217/696 (31%), Positives = 342/696 (49%), Gaps = 52/696 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI---D 379
P FP +PEN A + A DPD G G Y L N L++ D
Sbjct: 137 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 196
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
LI LDRE + + ++V +D G P+ S+T ++ V+V D ND+ PVF++ +
Sbjct: 197 KMPQLI-VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
++ EN G + QL ATD D NA + + F A F ++ +GLI+
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN--LVSNIARRLFHLNATTGLITIKE 313
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQ------ 553
+DRE +++L+V ASD G P A V + V D NDN P + RY+
Sbjct: 314 PLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNPVNDTV 368
Query: 554 -VREDVRPHTVVLRVTATDRDKDANGLVHY---NIISGNSRGHFAIDSLTGEIQVVAPLD 609
+ E++ +T + +T TD+D D NG V + I R F+ L ++ A LD
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL---LETAAYLD 425
Query: 610 FEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
+E+ +EYA+++ A DAG+PPL N + + I+V D ND+ P+F + VS+ EN G
Sbjct: 426 YESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 484
Query: 670 VIHIQAVDADHGENARLEYSLTGVAPDTP--FVINSATGWVSVSGPLDRESVEHYFFGVE 727
+ + A+DAD G NA++ Y L PD P F ++ TG ++V LDRE + Y F +
Sbjct: 485 LTKVSAMDADSGPNAKINYLL---GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTIL 541
Query: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--A 785
A+D+G PPL+++ +V V+++D NDN P FT EY+ + E+ +V +T D D
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR---ALHDHC 842
NSA++ I N + F I +Q GV + + D +++ + + A D +
Sbjct: 602 NSAVTLSILDEN--DDFTIDSQTGV--IRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 843 YVHINITDANTHRPVF----QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL- 897
V IN+ D N ++PVF + Y + + P G+ + + A D+D G NA + Y +
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIV 716
Query: 898 -EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVN-DVN 955
+ F ID ++G ITL D D + + + A D G P D+ + V+VN VN
Sbjct: 717 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP---DSLFSVVIVNLFVN 773
Query: 956 DNAPQFVASHYTGLVSEDAP--PFTSVLQISATDRD 989
++ + S +AP P T + +S+ D
Sbjct: 774 ESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 266 bits (681), Expect = 2e-70
Identities = 205/667 (30%), Positives = 314/667 (47%), Gaps = 42/667 (6%)
Query: 641 VVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPF- 699
+ DIND+ P+F +T +S+ EN+ + AVD D G N Y L + F
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL--IKSQNIFG 186
Query: 700 --VINSATG----WVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
VI + G + V LDRE + Y V+ D G P S++A + V+V D NDN
Sbjct: 187 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFA---ISTQGGV 810
P F E + + E+A VGTSV + A D D + N + A
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306
Query: 811 GLVTLALPLDYKQERYFKLVLTASDRALHD-HCYVHINITDANTHRP------VFQSAHY 863
GL+T+ PLD ++ KL++ ASD L V +N+TD N + P + +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRID---ADSGAITLQAPLD 920
+V ++E+ P+ + I +I+ +D D N R+T + +P FR+ ++ + A LD
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLLETAAYLD 425
Query: 921 YEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSV 980
YE Y + + A D G P + + + V D NDNAP F S T + E+ P +
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 981 LQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV 1040
++SA D D+ N ++ Y G D +F+++ +G++ V++LDRE Y T A
Sbjct: 486 TKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 1041 DRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNA 1100
D GVPPL + V++ V + D NDN+PVF E+ V EN V IT DPD G N+
Sbjct: 544 DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1101 HIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHV 1157
+ I++ N + F +D +G + I D E ++ Y V+A VSR A V +
Sbjct: 604 AVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 1158 RLVDQNDNSPVLNNFQILFNN--YVSNRSDTFPSGIIGRIPAYDPD--VSDHLFYSFERG 1213
+VD NDN PV F + +N Y T P ++ ++ A D D ++ + YS G
Sbjct: 662 NVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 718
Query: 1214 NELQLLVVNQTSGELRLSRKLD-----NNRPLVASMLVTVTDGLHSVTAQCVLRVVIITE 1268
N L ++Q +G + L K D +R LV + + D L SV + +T
Sbjct: 719 NTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTN 778
Query: 1269 ELLANSL 1275
L N L
Sbjct: 779 ATLINEL 785
Score = 236 bits (603), Expect = 2e-61
Identities = 174/539 (32%), Positives = 260/539 (48%), Gaps = 34/539 (6%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ HP F + + +PEN GT+V ++ A D D GE ++ +S + L+++ + LF ++
Sbjct: 244 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP------VF 433
+GLI LDRE H L V A D G + A MV V V D ND+ P +
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIV 361
Query: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDP--- 490
L EN+ I + TD DA N G F + P
Sbjct: 362 NPVNDTVVLSENIPLNTKIALITVTDKDADHN--------GRVTCFTDHEIPFRLRPVFS 413
Query: 491 RSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRY 550
L+ T+ +D E + Y + + A+D G+ P +SA + I V DENDNAP F++
Sbjct: 414 NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSA--MLFIKVKDENDNAPVFTQSFV 471
Query: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
+ E+ P + +V+A D D N ++Y ++ ++ F++D TG + VV LD
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDR 530
Query: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
E E +Y I A+D G PPL++N + ++D ND+ P+F + V EN P +V
Sbjct: 531 EKEDKYLFTILAKDNGVPPLTSNV-TVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
I D D+G+N+ + S+ D F I+S TG + + DRE E Y F V+A D
Sbjct: 590 GLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAED 647
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMK----EYHLRLNEDAAVGTSVVSVTAVDRDA- 785
G S+SA VT+ V+DVNDN+P F + Y L L GT V V AVD D
Sbjct: 648 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL-PSTNPGTVVFQVIAVDNDTG 706
Query: 786 -NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY 843
N+ + Y I GGNTR+ FAI + G +TL D ++++ A+D D +
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQE--TGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 763
Score = 84.3 bits (207), Expect = 2e-15
Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 27/260 (10%)
Query: 1013 EPTSGIVRTVRRLDREAVSVY----ELTAYAVDRGVPP--LRTPVSIQVMVQDVNDNAPV 1066
E T I T R+DRE + E Y V+ + P + V I+ +++D+NDNAP+
Sbjct: 79 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 1067 FPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFS----- 1121
FPA + + ENS + S AVDPD G N Y++++ +F +D+
Sbjct: 139 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQ--NIFGLDVIETPEGD 196
Query: 1122 --GELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHVRLVDQNDNSPVLNNFQILF 1176
+L +LD E + YV+ V+ R A + V + D NDN PV +I
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-- 254
Query: 1177 NNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNEL-----QLLVVNQTSGELRLS 1231
VS + + ++ A D D+ ++ F N + +L +N T+G + +
Sbjct: 255 --EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312
Query: 1232 RKLDNNRPLVASMLVTVTDG 1251
LD +LV +DG
Sbjct: 313 EPLDREETPNHKLLVLASDG 332
>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
Length = 1347
Score = 291 bits (746), Expect = 6e-78
Identities = 250/817 (30%), Positives = 379/817 (46%), Gaps = 75/817 (9%)
Query: 413 LSATTMVAVTVADRNDHSPVFEQAQ-YRETLRENVEEGYPILQLRATDGDAPPNANLRYR 471
LS T + AV +A HS E+ RE + ENV G + L + PN +L
Sbjct: 4 LSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLS---LIPNKSLTTA 60
Query: 472 FVGPPAARAAAAAAFEIDPRSGLISTSG-RVDREHMES---------YELVVEASDQGQE 521
+ I+ +G I T+G R+DRE + + YE+ V
Sbjct: 61 MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 115
Query: 522 PGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVH 581
P V++ + D NDNAP F + E+ ++ A D D NG+ +
Sbjct: 116 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 582 YNII-SGNSRGHFAIDSLTG----EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGL 636
Y +I S N G I++ G ++ V LD E + Y ++++ +D G P S +T +
Sbjct: 176 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRS-STAI 234
Query: 637 ASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPD 696
+ V D ND+ P+F T +VS+ ENAP+G SV + A DAD GENA++ +S + + +
Sbjct: 235 LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 294
Query: 697 TP---FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
F +N+ TG +++ PLDRE ++ V A D G P A A V V V DVNDN
Sbjct: 295 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNV 352
Query: 754 PEFTMK------EYHLRLNEDAAVGTSVVSVTAVDRDA--NSAIS----YQITGGNTRNR 801
P ++ + L+E+ + T + +T D+DA N ++ ++I R R
Sbjct: 353 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRLR 409
Query: 802 FAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVF 858
S Q L+ A LDY+ + + + L A+D L+ + I + D N + PVF
Sbjct: 410 PVFSNQ---FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF 466
Query: 859 QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL-EDNLPQFRIDADSGAITLQA 917
+ +VS+ E+ G + +SA D D G NA+I YLL D P+F +D +G +T+
Sbjct: 467 TQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK 526
Query: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
LD E + Y I A+DNG+P V V + D NDN+P F + Y V E+ P
Sbjct: 527 KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRH 586
Query: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
+V I+ TD D N V + + D DFTI+ +G++R DRE Y
Sbjct: 587 GTVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYV 643
Query: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVF---PAEEFEVRVKENSIVGSVVAQITAVDP 1094
A D G + + + V DVNDN PVF P+ V ++ G+VV Q+ AVD
Sbjct: 644 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDN 703
Query: 1095 DEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL-----------------IDLDYEARQE 1137
D G NA + Y IV GN +LF +D +G +T + DL
Sbjct: 704 DTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 763
Query: 1138 YVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQI 1174
V++V V+ AT+ LV ++ +PV N +I
Sbjct: 764 SVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEI 800
Score = 284 bits (727), Expect = 9e-76
Identities = 217/696 (31%), Positives = 342/696 (49%), Gaps = 52/696 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI---D 379
P FP +PEN A + A DPD G G Y L N L++ D
Sbjct: 137 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 196
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
LI LDRE + + ++V +D G P+ S+T ++ V+V D ND+ PVF++ +
Sbjct: 197 KMPQLI-VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
++ EN G + QL ATD D NA + + F A F ++ +GLI+
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN--LVSNIARRLFHLNATTGLITIKE 313
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQ------ 553
+DRE +++L+V ASD G P A V + V D NDN P + RY+
Sbjct: 314 PLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNPVNDTV 368
Query: 554 -VREDVRPHTVVLRVTATDRDKDANGLVHY---NIISGNSRGHFAIDSLTGEIQVVAPLD 609
+ E++ +T + +T TD+D D NG V + I R F+ L ++ A LD
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL---LETAAYLD 425
Query: 610 FEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
+E+ +EYA+++ A DAG+PPL N + + I+V D ND+ P+F + VS+ EN G
Sbjct: 426 YESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 484
Query: 670 VIHIQAVDADHGENARLEYSLTGVAPDTP--FVINSATGWVSVSGPLDRESVEHYFFGVE 727
+ + A+DAD G NA++ Y L PD P F ++ TG ++V LDRE + Y F +
Sbjct: 485 LTKVSAMDADSGPNAKINYLL---GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTIL 541
Query: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--A 785
A+D+G PPL+++ +V V+++D NDN P FT EY+ + E+ +V +T D D
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR---ALHDHC 842
NSA++ I N + F I +Q GV + + D +++ + + A D +
Sbjct: 602 NSAVTLSILDEN--DDFTIDSQTGV--IRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 843 YVHINITDANTHRPVF----QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL- 897
V IN+ D N ++PVF + Y + + P G+ + + A D+D G NA + Y +
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIV 716
Query: 898 -EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVN-DVN 955
+ F ID ++G ITL D D + + + A D G P D+ + V+VN VN
Sbjct: 717 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP---DSLFSVVIVNLFVN 773
Query: 956 DNAPQFVASHYTGLVSEDAP--PFTSVLQISATDRD 989
++ + S +AP P T + +S+ D
Sbjct: 774 ESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 266 bits (681), Expect = 2e-70
Identities = 205/667 (30%), Positives = 314/667 (47%), Gaps = 42/667 (6%)
Query: 641 VVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPF- 699
+ DIND+ P+F +T +S+ EN+ + AVD D G N Y L + F
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL--IKSQNIFG 186
Query: 700 --VINSATG----WVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
VI + G + V LDRE + Y V+ D G P S++A + V+V D NDN
Sbjct: 187 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFA---ISTQGGV 810
P F E + + E+A VGTSV + A D D + N + A
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306
Query: 811 GLVTLALPLDYKQERYFKLVLTASDRALHD-HCYVHINITDANTHRP------VFQSAHY 863
GL+T+ PLD ++ KL++ ASD L V +N+TD N + P + +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRID---ADSGAITLQAPLD 920
+V ++E+ P+ + I +I+ +D D N R+T + +P FR+ ++ + A LD
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLLETAAYLD 425
Query: 921 YEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSV 980
YE Y + + A D G P + + + V D NDNAP F S T + E+ P +
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 981 LQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV 1040
++SA D D+ N ++ Y G D +F+++ +G++ V++LDRE Y T A
Sbjct: 486 TKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 1041 DRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNA 1100
D GVPPL + V++ V + D NDN+PVF E+ V EN V IT DPD G N+
Sbjct: 544 DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1101 HIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHV 1157
+ I++ N + F +D +G + I D E ++ Y V+A VSR A V +
Sbjct: 604 AVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 1158 RLVDQNDNSPVLNNFQILFNN--YVSNRSDTFPSGIIGRIPAYDPD--VSDHLFYSFERG 1213
+VD NDN PV F + +N Y T P ++ ++ A D D ++ + YS G
Sbjct: 662 NVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 718
Query: 1214 NELQLLVVNQTSGELRLSRKLD-----NNRPLVASMLVTVTDGLHSVTAQCVLRVVIITE 1268
N L ++Q +G + L K D +R LV + + D L SV + +T
Sbjct: 719 NTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTN 778
Query: 1269 ELLANSL 1275
L N L
Sbjct: 779 ATLINEL 785
Score = 236 bits (603), Expect = 2e-61
Identities = 174/539 (32%), Positives = 260/539 (48%), Gaps = 34/539 (6%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ HP F + + +PEN GT+V ++ A D D GE ++ +S + L+++ + LF ++
Sbjct: 244 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP------VF 433
+GLI LDRE H L V A D G + A MV V V D ND+ P +
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIV 361
Query: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDP--- 490
L EN+ I + TD DA N G F + P
Sbjct: 362 NPVNDTVVLSENIPLNTKIALITVTDKDADHN--------GRVTCFTDHEIPFRLRPVFS 413
Query: 491 RSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRY 550
L+ T+ +D E + Y + + A+D G+ P +SA + I V DENDNAP F++
Sbjct: 414 NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSA--MLFIKVKDENDNAPVFTQSFV 471
Query: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
+ E+ P + +V+A D D N ++Y ++ ++ F++D TG + VV LD
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDR 530
Query: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
E E +Y I A+D G PPL++N + ++D ND+ P+F + V EN P +V
Sbjct: 531 EKEDKYLFTILAKDNGVPPLTSNV-TVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
I D D+G+N+ + S+ D F I+S TG + + DRE E Y F V+A D
Sbjct: 590 GLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAED 647
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMK----EYHLRLNEDAAVGTSVVSVTAVDRDA- 785
G S+SA VT+ V+DVNDN+P F + Y L L GT V V AVD D
Sbjct: 648 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL-PSTNPGTVVFQVIAVDNDTG 706
Query: 786 -NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY 843
N+ + Y I GGNTR+ FAI + G +TL D ++++ A+D D +
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQE--TGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 763
Score = 84.3 bits (207), Expect = 2e-15
Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 27/260 (10%)
Query: 1013 EPTSGIVRTVRRLDREAVSVY----ELTAYAVDRGVPP--LRTPVSIQVMVQDVNDNAPV 1066
E T I T R+DRE + E Y V+ + P + V I+ +++D+NDNAP+
Sbjct: 79 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 1067 FPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFS----- 1121
FPA + + ENS + S AVDPD G N Y++++ +F +D+
Sbjct: 139 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQ--NIFGLDVIETPEGD 196
Query: 1122 --GELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHVRLVDQNDNSPVLNNFQILF 1176
+L +LD E + YV+ V+ R A + V + D NDN PV +I
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-- 254
Query: 1177 NNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNEL-----QLLVVNQTSGELRLS 1231
VS + + ++ A D D+ ++ F N + +L +N T+G + +
Sbjct: 255 --EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312
Query: 1232 RKLDNNRPLVASMLVTVTDG 1251
LD +LV +DG
Sbjct: 313 EPLDREETPNHKLLVLASDG 332
>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
sapiens]
Length = 1025
Score = 291 bits (746), Expect = 6e-78
Identities = 250/817 (30%), Positives = 379/817 (46%), Gaps = 75/817 (9%)
Query: 413 LSATTMVAVTVADRNDHSPVFEQAQ-YRETLRENVEEGYPILQLRATDGDAPPNANLRYR 471
LS T + AV +A HS E+ RE + ENV G + L + PN +L
Sbjct: 4 LSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLS---LIPNKSLTTA 60
Query: 472 FVGPPAARAAAAAAFEIDPRSGLISTSG-RVDREHMES---------YELVVEASDQGQE 521
+ I+ +G I T+G R+DRE + + YE+ V
Sbjct: 61 MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 115
Query: 522 PGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVH 581
P V++ + D NDNAP F + E+ ++ A D D NG+ +
Sbjct: 116 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 582 YNII-SGNSRGHFAIDSLTG----EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGL 636
Y +I S N G I++ G ++ V LD E + Y ++++ +D G P S +T +
Sbjct: 176 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRS-STAI 234
Query: 637 ASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPD 696
+ V D ND+ P+F T +VS+ ENAP+G SV + A DAD GENA++ +S + + +
Sbjct: 235 LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 294
Query: 697 TP---FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
F +N+ TG +++ PLDRE ++ V A D G P A A V V V DVNDN
Sbjct: 295 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNV 352
Query: 754 PEFTMK------EYHLRLNEDAAVGTSVVSVTAVDRDA--NSAIS----YQITGGNTRNR 801
P ++ + L+E+ + T + +T D+DA N ++ ++I R R
Sbjct: 353 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRLR 409
Query: 802 FAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVF 858
S Q L+ A LDY+ + + + L A+D L+ + I + D N + PVF
Sbjct: 410 PVFSNQ---FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF 466
Query: 859 QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL-EDNLPQFRIDADSGAITLQA 917
+ +VS+ E+ G + +SA D D G NA+I YLL D P+F +D +G +T+
Sbjct: 467 TQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK 526
Query: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
LD E + Y I A+DNG+P V V + D NDN+P F + Y V E+ P
Sbjct: 527 KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRH 586
Query: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
+V I+ TD D N V + + D DFTI+ +G++R DRE Y
Sbjct: 587 GTVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYV 643
Query: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVF---PAEEFEVRVKENSIVGSVVAQITAVDP 1094
A D G + + + V DVNDN PVF P+ V ++ G+VV Q+ AVD
Sbjct: 644 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDN 703
Query: 1095 DEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL-----------------IDLDYEARQE 1137
D G NA + Y IV GN +LF +D +G +T + DL
Sbjct: 704 DTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 763
Query: 1138 YVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQI 1174
V++V V+ AT+ LV ++ +PV N +I
Sbjct: 764 SVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEI 800
Score = 284 bits (727), Expect = 9e-76
Identities = 217/696 (31%), Positives = 342/696 (49%), Gaps = 52/696 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI---D 379
P FP +PEN A + A DPD G G Y L N L++ D
Sbjct: 137 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 196
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
LI LDRE + + ++V +D G P+ S+T ++ V+V D ND+ PVF++ +
Sbjct: 197 KMPQLI-VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 255
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
++ EN G + QL ATD D NA + + F A F ++ +GLI+
Sbjct: 256 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN--LVSNIARRLFHLNATTGLITIKE 313
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQ------ 553
+DRE +++L+V ASD G P A V + V D NDN P + RY+
Sbjct: 314 PLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNPVNDTV 368
Query: 554 -VREDVRPHTVVLRVTATDRDKDANGLVHY---NIISGNSRGHFAIDSLTGEIQVVAPLD 609
+ E++ +T + +T TD+D D NG V + I R F+ L ++ A LD
Sbjct: 369 VLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL---LETAAYLD 425
Query: 610 FEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
+E+ +EYA+++ A DAG+PPL N + + I+V D ND+ P+F + VS+ EN G
Sbjct: 426 YESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 484
Query: 670 VIHIQAVDADHGENARLEYSLTGVAPDTP--FVINSATGWVSVSGPLDRESVEHYFFGVE 727
+ + A+DAD G NA++ Y L PD P F ++ TG ++V LDRE + Y F +
Sbjct: 485 LTKVSAMDADSGPNAKINYLL---GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTIL 541
Query: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--A 785
A+D+G PPL+++ +V V+++D NDN P FT EY+ + E+ +V +T D D
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR---ALHDHC 842
NSA++ I N + F I +Q GV + + D +++ + + A D +
Sbjct: 602 NSAVTLSILDEN--DDFTIDSQTGV--IRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 657
Query: 843 YVHINITDANTHRPVF----QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL- 897
V IN+ D N ++PVF + Y + + P G+ + + A D+D G NA + Y +
Sbjct: 658 KVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQVIAVDNDTGMNAEVRYSIV 716
Query: 898 -EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVN-DVN 955
+ F ID ++G ITL D D + + + A D G P D+ + V+VN VN
Sbjct: 717 GGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP---DSLFSVVIVNLFVN 773
Query: 956 DNAPQFVASHYTGLVSEDAP--PFTSVLQISATDRD 989
++ + S +AP P T + +S+ D
Sbjct: 774 ESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSD 809
Score = 266 bits (681), Expect = 2e-70
Identities = 205/667 (30%), Positives = 314/667 (47%), Gaps = 42/667 (6%)
Query: 641 VVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPF- 699
+ DIND+ P+F +T +S+ EN+ + AVD D G N Y L + F
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL--IKSQNIFG 186
Query: 700 --VINSATG----WVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
VI + G + V LDRE + Y V+ D G P S++A + V+V D NDN
Sbjct: 187 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 246
Query: 754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFA---ISTQGGV 810
P F E + + E+A VGTSV + A D D + N + A
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306
Query: 811 GLVTLALPLDYKQERYFKLVLTASDRALHD-HCYVHINITDANTHRP------VFQSAHY 863
GL+T+ PLD ++ KL++ ASD L V +N+TD N + P + +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRID---ADSGAITLQAPLD 920
+V ++E+ P+ + I +I+ +D D N R+T + +P FR+ ++ + A LD
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQFLLETAAYLD 425
Query: 921 YEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSV 980
YE Y + + A D G P + + + V D NDNAP F S T + E+ P +
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 485
Query: 981 LQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV 1040
++SA D D+ N ++ Y G D +F+++ +G++ V++LDRE Y T A
Sbjct: 486 TKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK 543
Query: 1041 DRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNA 1100
D GVPPL + V++ V + D NDN+PVF E+ V EN V IT DPD G N+
Sbjct: 544 DNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1101 HIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHV 1157
+ I++ N + F +D +G + I D E ++ Y V+A VSR A V +
Sbjct: 604 AVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTI 661
Query: 1158 RLVDQNDNSPVLNNFQILFNN--YVSNRSDTFPSGIIGRIPAYDPD--VSDHLFYSFERG 1213
+VD NDN PV F + +N Y T P ++ ++ A D D ++ + YS G
Sbjct: 662 NVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGG 718
Query: 1214 NELQLLVVNQTSGELRLSRKLD-----NNRPLVASMLVTVTDGLHSVTAQCVLRVVIITE 1268
N L ++Q +G + L K D +R LV + + D L SV + +T
Sbjct: 719 NTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTN 778
Query: 1269 ELLANSL 1275
L N L
Sbjct: 779 ATLINEL 785
Score = 236 bits (603), Expect = 2e-61
Identities = 174/539 (32%), Positives = 260/539 (48%), Gaps = 34/539 (6%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ HP F + + +PEN GT+V ++ A D D GE ++ +S + L+++ + LF ++
Sbjct: 244 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 303
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP------VF 433
+GLI LDRE H L V A D G + A MV V V D ND+ P +
Sbjct: 304 ATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIV 361
Query: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDP--- 490
L EN+ I + TD DA N G F + P
Sbjct: 362 NPVNDTVVLSENIPLNTKIALITVTDKDADHN--------GRVTCFTDHEIPFRLRPVFS 413
Query: 491 RSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRY 550
L+ T+ +D E + Y + + A+D G+ P +SA + I V DENDNAP F++
Sbjct: 414 NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSA--MLFIKVKDENDNAPVFTQSFV 471
Query: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
+ E+ P + +V+A D D N ++Y ++ ++ F++D TG + VV LD
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDR 530
Query: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
E E +Y I A+D G PPL++N + ++D ND+ P+F + V EN P +V
Sbjct: 531 EKEDKYLFTILAKDNGVPPLTSNV-TVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
I D D+G+N+ + S+ D F I+S TG + + DRE E Y F V+A D
Sbjct: 590 GLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAED 647
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMK----EYHLRLNEDAAVGTSVVSVTAVDRDA- 785
G S+SA VT+ V+DVNDN+P F + Y L L GT V V AVD D
Sbjct: 648 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL-PSTNPGTVVFQVIAVDNDTG 706
Query: 786 -NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY 843
N+ + Y I GGNTR+ FAI + G +TL D ++++ A+D D +
Sbjct: 707 MNAEVRYSIVGGNTRDLFAIDQE--TGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 763
Score = 84.3 bits (207), Expect = 2e-15
Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 27/260 (10%)
Query: 1013 EPTSGIVRTVRRLDREAVSVY----ELTAYAVDRGVPP--LRTPVSIQVMVQDVNDNAPV 1066
E T I T R+DRE + E Y V+ + P + V I+ +++D+NDNAP+
Sbjct: 79 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 138
Query: 1067 FPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFS----- 1121
FPA + + ENS + S AVDPD G N Y++++ +F +D+
Sbjct: 139 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQ--NIFGLDVIETPEGD 196
Query: 1122 --GELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHVRLVDQNDNSPVLNNFQILF 1176
+L +LD E + YV+ V+ R A + V + D NDN PV +I
Sbjct: 197 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-- 254
Query: 1177 NNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNEL-----QLLVVNQTSGELRLS 1231
VS + + ++ A D D+ ++ F N + +L +N T+G + +
Sbjct: 255 --EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312
Query: 1232 RKLDNNRPLVASMLVTVTDG 1251
LD +LV +DG
Sbjct: 313 EPLDREETPNHKLLVLASDG 332
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 288 bits (738), Expect = 5e-77
Identities = 248/817 (30%), Positives = 378/817 (46%), Gaps = 75/817 (9%)
Query: 413 LSATTMVAVTVADRNDHSPVFEQAQ-YRETLRENVEEGYPILQLRATDGDAPPNANLRYR 471
LS T + AV + HS E+ RE + ENV G + L + PN +L
Sbjct: 36 LSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLS---LIPNKSLTTT 92
Query: 472 FVGPPAARAAAAAAFEIDPRSGLISTSG-RVDREHMES---------YELVVEASDQGQE 521
+ I+ +G I T+G R+DRE + + YE+ V
Sbjct: 93 MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 147
Query: 522 PGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVH 581
P V++ + D NDNAP F + E+ ++ A D D NG+ +
Sbjct: 148 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 207
Query: 582 YNII-SGNSRGHFAIDSLTG----EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGL 636
Y +I S N G I++ G ++ V LD E + Y ++++ +D G P S +T +
Sbjct: 208 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRS-STAI 266
Query: 637 ASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPD 696
+ V D ND+ P+F T +VS+ ENAP+G SV + A DAD GENA++ +S + + +
Sbjct: 267 LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 326
Query: 697 TP---FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
F +N+ TG +++ PLDRE ++ V A D G P A A V V V DVNDN
Sbjct: 327 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNV 384
Query: 754 PEFTMK------EYHLRLNEDAAVGTSVVSVTAVDRDA--NSAIS----YQITGGNTRNR 801
P ++ + L+E+ + T + +T D+DA N ++ ++I R R
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRLR 441
Query: 802 FAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVF 858
S Q L+ A LDY+ + + + L A+D L+ + I + D N + PVF
Sbjct: 442 PVFSNQ---FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF 498
Query: 859 QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL-EDNLPQFRIDADSGAITLQA 917
+ +VS+ E+ G ++ +SA+D D G NA I YLL D P+F +D +G +T+
Sbjct: 499 TQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK 558
Query: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
LD E + Y I A+DNG+P V V + D NDN+P F + Y V E+ P
Sbjct: 559 KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRH 618
Query: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
+V I+ TD D N V + + D DFTI+ +G++R DRE Y
Sbjct: 619 GTVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYV 675
Query: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVR---VKENSIVGSVVAQITAVDP 1094
A D G + + + V DVNDN PVF + V ++ G+VV Q+ AVD
Sbjct: 676 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDN 735
Query: 1095 DEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL-----------------IDLDYEARQE 1137
D G NA + Y IV GN +LF +D +G +T + DL
Sbjct: 736 DTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 795
Query: 1138 YVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQI 1174
V++V V+ AT+ LV ++ +PV N +I
Sbjct: 796 SVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEI 832
Score = 282 bits (721), Expect = 4e-75
Identities = 218/695 (31%), Positives = 339/695 (48%), Gaps = 50/695 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI---D 379
P FP +PEN A + A DPD G G Y L N L++ D
Sbjct: 169 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 228
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
LI LDRE + + ++V +D G P+ S+T ++ V+V D ND+ PVF++ +
Sbjct: 229 KMPQLI-VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 287
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
++ EN G + QL ATD D NA + + F A F ++ +GLI+
Sbjct: 288 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN--LVSNIARRLFHLNATTGLITIKE 345
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQ------ 553
+DRE +++L+V ASD G P A V + V D NDN P + RY+
Sbjct: 346 PLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNPVNDTV 400
Query: 554 -VREDVRPHTVVLRVTATDRDKDANGLVHY---NIISGNSRGHFAIDSLTGEIQVVAPLD 609
+ E++ +T + +T TD+D D NG V + I R F+ L ++ A LD
Sbjct: 401 VLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL---LENAAYLD 457
Query: 610 FEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
+E+ +EYA+++ A DAG+PPL N + + I+V D ND+ P+F + VS+ EN G
Sbjct: 458 YESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 516
Query: 670 VIHIQAVDADHGENARLEYSLTGVAPDTP--FVINSATGWVSVSGPLDRESVEHYFFGVE 727
++ + A DAD G NA + Y L PD P F ++ TG ++V LDRE + Y F +
Sbjct: 517 LMKVSATDADSGPNAEINYLL---GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTIL 573
Query: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--A 785
A+D+G PPL+++ +V V+++D NDN P FT EY + E+ +V +T D D
Sbjct: 574 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 633
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR---ALHDHC 842
NSA++ I N + F I +Q GV + + D +++ + + A D +
Sbjct: 634 NSAVTLSILDEN--DDFTIDSQTGV--IRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 689
Query: 843 YVHINITDANTHRPVFQSAHYSVSVNEDRPM---GSTIVVISASDDDVGENARITYLL-- 897
V IN+ D N ++PVF Y+ S P G+ + + A D+D G NA + Y +
Sbjct: 690 KVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG 749
Query: 898 EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVN-DVND 956
+ F ID ++G ITL D D + + + A D G P D+ + V+VN VN+
Sbjct: 750 GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP---DSLFSVVIVNLFVNE 806
Query: 957 NAPQFVASHYTGLVSEDAP--PFTSVLQISATDRD 989
+ + S +AP P T + +S+ D
Sbjct: 807 SVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 269 bits (688), Expect = 3e-71
Identities = 206/666 (30%), Positives = 312/666 (46%), Gaps = 40/666 (6%)
Query: 641 VVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPF- 699
+ DIND+ P+F +T +S+ EN+ + AVD D G N Y L + F
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL--IKSQNIFG 218
Query: 700 --VINSATG----WVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
VI + G + V LDRE + Y V+ D G P S++A + V+V D NDN
Sbjct: 219 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 278
Query: 754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFA---ISTQGGV 810
P F E + + E+A VGTSV + A D D + N + A
Sbjct: 279 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 338
Query: 811 GLVTLALPLDYKQERYFKLVLTASDRALHD-HCYVHINITDANTHRP------VFQSAHY 863
GL+T+ PLD ++ KL++ ASD L V +N+TD N + P + +
Sbjct: 339 GLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 398
Query: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQ--APLDY 921
+V ++E+ P+ + I +I+ +D D N R+T + +P S L+ A LDY
Sbjct: 399 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDY 458
Query: 922 EDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVL 981
E Y + + A D G P + + + V D NDNAP F S T + E+ P ++
Sbjct: 459 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLM 518
Query: 982 QISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
++SATD D+ N + Y G D +F+++ +G++ V++LDRE Y T A D
Sbjct: 519 KVSATDADSGPNAEINYLL--GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKD 576
Query: 1042 RGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAH 1101
GVPPL + V++ V + D NDN+PVF E++ V EN V IT DPD G N+
Sbjct: 577 NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSA 636
Query: 1102 IMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHVR 1158
+ I++ N + F +D +G + I D E ++ Y V+A VSR A V +
Sbjct: 637 VTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTIN 694
Query: 1159 LVDQNDNSPVLNNFQILFNNYVSN--RSDTFPSGIIGRIPAYDPD--VSDHLFYSFERGN 1214
+VD NDN PV F + NY T P ++ ++ A D D ++ + YS GN
Sbjct: 695 VVDVNDNKPV---FIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 751
Query: 1215 ELQLLVVNQTSGELRLSRKLD-----NNRPLVASMLVTVTDGLHSVTAQCVLRVVIITEE 1269
L ++Q +G + L K D +R LV + + D L SV + +T
Sbjct: 752 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 811
Query: 1270 LLANSL 1275
L N L
Sbjct: 812 TLINEL 817
Score = 240 bits (612), Expect = 2e-62
Identities = 172/538 (31%), Positives = 261/538 (48%), Gaps = 32/538 (5%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ HP F + + +PEN GT+V ++ A D D GE ++ +S + L+++ + LF ++
Sbjct: 276 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 335
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP------VF 433
+GLI LDRE H L V A D G + A MV V V D ND+ P +
Sbjct: 336 ATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIV 393
Query: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDP--- 490
L EN+ I + TD DA N G F + P
Sbjct: 394 NPVNDTVVLSENIPLNTKIALITVTDKDADHN--------GRVTCFTDHEIPFRLRPVFS 445
Query: 491 RSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRY 550
L+ + +D E + Y + + A+D G+ P +SA + I V DENDNAP F++
Sbjct: 446 NQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSA--MLFIKVKDENDNAPVFTQSFV 503
Query: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
+ E+ P +++V+ATD D N ++Y ++ ++ F++D TG + VV LD
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDR 562
Query: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
E E +Y I A+D G PPL++N + ++D ND+ P+F ++ V EN P +V
Sbjct: 563 EKEDKYLFTILAKDNGVPPLTSNV-TVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV 621
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
I D D+G+N+ + S+ D F I+S TG + + DRE E Y F V+A D
Sbjct: 622 GLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAED 679
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLN---EDAAVGTSVVSVTAVDRDA-- 785
G S+SA VT+ V+DVNDN+P F + Y+ GT V V AVD D
Sbjct: 680 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGM 739
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY 843
N+ + Y I GGNTR+ FAI + G +TL D ++++ A+D D +
Sbjct: 740 NAEVRYSIVGGNTRDLFAIDQE--TGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 795
Score = 84.3 bits (207), Expect = 2e-15
Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 27/260 (10%)
Query: 1013 EPTSGIVRTVRRLDREAVSVY----ELTAYAVDRGVPP--LRTPVSIQVMVQDVNDNAPV 1066
E T I T R+DRE + E Y V+ + P + V I+ +++D+NDNAP+
Sbjct: 111 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 170
Query: 1067 FPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFS----- 1121
FPA + + ENS + S AVDPD G N Y++++ +F +D+
Sbjct: 171 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQ--NIFGLDVIETPEGD 228
Query: 1122 --GELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHVRLVDQNDNSPVLNNFQILF 1176
+L +LD E + YV+ V+ R A + V + D NDN PV +I
Sbjct: 229 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-- 286
Query: 1177 NNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNEL-----QLLVVNQTSGELRLS 1231
VS + + ++ A D D+ ++ F N + +L +N T+G + +
Sbjct: 287 --EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 344
Query: 1232 RKLDNNRPLVASMLVTVTDG 1251
LD +LV +DG
Sbjct: 345 EPLDREETPNHKLLVLASDG 364
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 288 bits (738), Expect = 5e-77
Identities = 248/817 (30%), Positives = 378/817 (46%), Gaps = 75/817 (9%)
Query: 413 LSATTMVAVTVADRNDHSPVFEQAQ-YRETLRENVEEGYPILQLRATDGDAPPNANLRYR 471
LS T + AV + HS E+ RE + ENV G + L + PN +L
Sbjct: 36 LSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLS---LIPNKSLTTT 92
Query: 472 FVGPPAARAAAAAAFEIDPRSGLISTSG-RVDREHMES---------YELVVEASDQGQE 521
+ I+ +G I T+G R+DRE + + YE+ V
Sbjct: 93 MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 147
Query: 522 PGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVH 581
P V++ + D NDNAP F + E+ ++ A D D NG+ +
Sbjct: 148 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 207
Query: 582 YNII-SGNSRGHFAIDSLTG----EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGL 636
Y +I S N G I++ G ++ V LD E + Y ++++ +D G P S +T +
Sbjct: 208 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRS-STAI 266
Query: 637 ASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPD 696
+ V D ND+ P+F T +VS+ ENAP+G SV + A DAD GENA++ +S + + +
Sbjct: 267 LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 326
Query: 697 TP---FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
F +N+ TG +++ PLDRE ++ V A D G P A A V V V DVNDN
Sbjct: 327 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNV 384
Query: 754 PEFTMK------EYHLRLNEDAAVGTSVVSVTAVDRDA--NSAIS----YQITGGNTRNR 801
P ++ + L+E+ + T + +T D+DA N ++ ++I R R
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRLR 441
Query: 802 FAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVF 858
S Q L+ A LDY+ + + + L A+D L+ + I + D N + PVF
Sbjct: 442 PVFSNQ---FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF 498
Query: 859 QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL-EDNLPQFRIDADSGAITLQA 917
+ +VS+ E+ G ++ +SA+D D G NA I YLL D P+F +D +G +T+
Sbjct: 499 TQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK 558
Query: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
LD E + Y I A+DNG+P V V + D NDN+P F + Y V E+ P
Sbjct: 559 KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRH 618
Query: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
+V I+ TD D N V + + D DFTI+ +G++R DRE Y
Sbjct: 619 GTVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYV 675
Query: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVR---VKENSIVGSVVAQITAVDP 1094
A D G + + + V DVNDN PVF + V ++ G+VV Q+ AVD
Sbjct: 676 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDN 735
Query: 1095 DEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL-----------------IDLDYEARQE 1137
D G NA + Y IV GN +LF +D +G +T + DL
Sbjct: 736 DTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 795
Query: 1138 YVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQI 1174
V++V V+ AT+ LV ++ +PV N +I
Sbjct: 796 SVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEI 832
Score = 282 bits (721), Expect = 4e-75
Identities = 218/695 (31%), Positives = 339/695 (48%), Gaps = 50/695 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI---D 379
P FP +PEN A + A DPD G G Y L N L++ D
Sbjct: 169 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 228
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
LI LDRE + + ++V +D G P+ S+T ++ V+V D ND+ PVF++ +
Sbjct: 229 KMPQLI-VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 287
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
++ EN G + QL ATD D NA + + F A F ++ +GLI+
Sbjct: 288 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN--LVSNIARRLFHLNATTGLITIKE 345
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQ------ 553
+DRE +++L+V ASD G P A V + V D NDN P + RY+
Sbjct: 346 PLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNPVNDTV 400
Query: 554 -VREDVRPHTVVLRVTATDRDKDANGLVHY---NIISGNSRGHFAIDSLTGEIQVVAPLD 609
+ E++ +T + +T TD+D D NG V + I R F+ L ++ A LD
Sbjct: 401 VLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL---LENAAYLD 457
Query: 610 FEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
+E+ +EYA+++ A DAG+PPL N + + I+V D ND+ P+F + VS+ EN G
Sbjct: 458 YESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 516
Query: 670 VIHIQAVDADHGENARLEYSLTGVAPDTP--FVINSATGWVSVSGPLDRESVEHYFFGVE 727
++ + A DAD G NA + Y L PD P F ++ TG ++V LDRE + Y F +
Sbjct: 517 LMKVSATDADSGPNAEINYLL---GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTIL 573
Query: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--A 785
A+D+G PPL+++ +V V+++D NDN P FT EY + E+ +V +T D D
Sbjct: 574 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 633
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR---ALHDHC 842
NSA++ I N + F I +Q GV + + D +++ + + A D +
Sbjct: 634 NSAVTLSILDEN--DDFTIDSQTGV--IRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 689
Query: 843 YVHINITDANTHRPVFQSAHYSVSVNEDRPM---GSTIVVISASDDDVGENARITYLL-- 897
V IN+ D N ++PVF Y+ S P G+ + + A D+D G NA + Y +
Sbjct: 690 KVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG 749
Query: 898 EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVN-DVND 956
+ F ID ++G ITL D D + + + A D G P D+ + V+VN VN+
Sbjct: 750 GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP---DSLFSVVIVNLFVNE 806
Query: 957 NAPQFVASHYTGLVSEDAP--PFTSVLQISATDRD 989
+ + S +AP P T + +S+ D
Sbjct: 807 SVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 269 bits (688), Expect = 3e-71
Identities = 206/666 (30%), Positives = 312/666 (46%), Gaps = 40/666 (6%)
Query: 641 VVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPF- 699
+ DIND+ P+F +T +S+ EN+ + AVD D G N Y L + F
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL--IKSQNIFG 218
Query: 700 --VINSATG----WVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
VI + G + V LDRE + Y V+ D G P S++A + V+V D NDN
Sbjct: 219 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 278
Query: 754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFA---ISTQGGV 810
P F E + + E+A VGTSV + A D D + N + A
Sbjct: 279 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 338
Query: 811 GLVTLALPLDYKQERYFKLVLTASDRALHD-HCYVHINITDANTHRP------VFQSAHY 863
GL+T+ PLD ++ KL++ ASD L V +N+TD N + P + +
Sbjct: 339 GLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 398
Query: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQ--APLDY 921
+V ++E+ P+ + I +I+ +D D N R+T + +P S L+ A LDY
Sbjct: 399 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDY 458
Query: 922 EDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVL 981
E Y + + A D G P + + + V D NDNAP F S T + E+ P ++
Sbjct: 459 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLM 518
Query: 982 QISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
++SATD D+ N + Y G D +F+++ +G++ V++LDRE Y T A D
Sbjct: 519 KVSATDADSGPNAEINYLL--GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKD 576
Query: 1042 RGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAH 1101
GVPPL + V++ V + D NDN+PVF E++ V EN V IT DPD G N+
Sbjct: 577 NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSA 636
Query: 1102 IMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHVR 1158
+ I++ N + F +D +G + I D E ++ Y V+A VSR A V +
Sbjct: 637 VTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTIN 694
Query: 1159 LVDQNDNSPVLNNFQILFNNYVSN--RSDTFPSGIIGRIPAYDPD--VSDHLFYSFERGN 1214
+VD NDN PV F + NY T P ++ ++ A D D ++ + YS GN
Sbjct: 695 VVDVNDNKPV---FIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 751
Query: 1215 ELQLLVVNQTSGELRLSRKLD-----NNRPLVASMLVTVTDGLHSVTAQCVLRVVIITEE 1269
L ++Q +G + L K D +R LV + + D L SV + +T
Sbjct: 752 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 811
Query: 1270 LLANSL 1275
L N L
Sbjct: 812 TLINEL 817
Score = 240 bits (612), Expect = 2e-62
Identities = 172/538 (31%), Positives = 261/538 (48%), Gaps = 32/538 (5%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ HP F + + +PEN GT+V ++ A D D GE ++ +S + L+++ + LF ++
Sbjct: 276 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 335
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP------VF 433
+GLI LDRE H L V A D G + A MV V V D ND+ P +
Sbjct: 336 ATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIV 393
Query: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDP--- 490
L EN+ I + TD DA N G F + P
Sbjct: 394 NPVNDTVVLSENIPLNTKIALITVTDKDADHN--------GRVTCFTDHEIPFRLRPVFS 445
Query: 491 RSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRY 550
L+ + +D E + Y + + A+D G+ P +SA + I V DENDNAP F++
Sbjct: 446 NQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSA--MLFIKVKDENDNAPVFTQSFV 503
Query: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
+ E+ P +++V+ATD D N ++Y ++ ++ F++D TG + VV LD
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDR 562
Query: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
E E +Y I A+D G PPL++N + ++D ND+ P+F ++ V EN P +V
Sbjct: 563 EKEDKYLFTILAKDNGVPPLTSNV-TVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV 621
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
I D D+G+N+ + S+ D F I+S TG + + DRE E Y F V+A D
Sbjct: 622 GLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAED 679
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLN---EDAAVGTSVVSVTAVDRDA-- 785
G S+SA VT+ V+DVNDN+P F + Y+ GT V V AVD D
Sbjct: 680 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGM 739
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY 843
N+ + Y I GGNTR+ FAI + G +TL D ++++ A+D D +
Sbjct: 740 NAEVRYSIVGGNTRDLFAIDQE--TGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 795
Score = 84.3 bits (207), Expect = 2e-15
Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 27/260 (10%)
Query: 1013 EPTSGIVRTVRRLDREAVSVY----ELTAYAVDRGVPP--LRTPVSIQVMVQDVNDNAPV 1066
E T I T R+DRE + E Y V+ + P + V I+ +++D+NDNAP+
Sbjct: 111 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 170
Query: 1067 FPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFS----- 1121
FPA + + ENS + S AVDPD G N Y++++ +F +D+
Sbjct: 171 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQ--NIFGLDVIETPEGD 228
Query: 1122 --GELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHVRLVDQNDNSPVLNNFQILF 1176
+L +LD E + YV+ V+ R A + V + D NDN PV +I
Sbjct: 229 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-- 286
Query: 1177 NNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNEL-----QLLVVNQTSGELRLS 1231
VS + + ++ A D D+ ++ F N + +L +N T+G + +
Sbjct: 287 --EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 344
Query: 1232 RKLDNNRPLVASMLVTVTDG 1251
LD +LV +DG
Sbjct: 345 EPLDREETPNHKLLVLASDG 364
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 288 bits (738), Expect = 5e-77
Identities = 248/817 (30%), Positives = 378/817 (46%), Gaps = 75/817 (9%)
Query: 413 LSATTMVAVTVADRNDHSPVFEQAQ-YRETLRENVEEGYPILQLRATDGDAPPNANLRYR 471
LS T + AV + HS E+ RE + ENV G + L + PN +L
Sbjct: 25 LSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLS---LIPNKSLTTT 81
Query: 472 FVGPPAARAAAAAAFEIDPRSGLISTSG-RVDREHMES---------YELVVEASDQGQE 521
+ I+ +G I T+G R+DRE + + YE+ V
Sbjct: 82 MQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAIL----- 136
Query: 522 PGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVH 581
P V++ + D NDNAP F + E+ ++ A D D NG+ +
Sbjct: 137 PDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 196
Query: 582 YNII-SGNSRGHFAIDSLTG----EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGL 636
Y +I S N G I++ G ++ V LD E + Y ++++ +D G P S +T +
Sbjct: 197 YELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRS-STAI 255
Query: 637 ASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPD 696
+ V D ND+ P+F T +VS+ ENAP+G SV + A DAD GENA++ +S + + +
Sbjct: 256 LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 315
Query: 697 TP---FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
F +N+ TG +++ PLDRE ++ V A D G P A A V V V DVNDN
Sbjct: 316 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNV 373
Query: 754 PEFTMK------EYHLRLNEDAAVGTSVVSVTAVDRDA--NSAIS----YQITGGNTRNR 801
P ++ + L+E+ + T + +T D+DA N ++ ++I R R
Sbjct: 374 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP---FRLR 430
Query: 802 FAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVF 858
S Q L+ A LDY+ + + + L A+D L+ + I + D N + PVF
Sbjct: 431 PVFSNQ---FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF 487
Query: 859 QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL-EDNLPQFRIDADSGAITLQA 917
+ +VS+ E+ G ++ +SA+D D G NA I YLL D P+F +D +G +T+
Sbjct: 488 TQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK 547
Query: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPF 977
LD E + Y I A+DNG+P V V + D NDN+P F + Y V E+ P
Sbjct: 548 KLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRH 607
Query: 978 TSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTA 1037
+V I+ TD D N V + + D DFTI+ +G++R DRE Y
Sbjct: 608 GTVGLITVTDPDYGDNSAVTLSILDEND---DFTIDSQTGVIRPNISFDREKQESYTFYV 664
Query: 1038 YAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVR---VKENSIVGSVVAQITAVDP 1094
A D G + + + V DVNDN PVF + V ++ G+VV Q+ AVD
Sbjct: 665 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDN 724
Query: 1095 DEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL-----------------IDLDYEARQE 1137
D G NA + Y IV GN +LF +D +G +T + DL
Sbjct: 725 DTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 784
Query: 1138 YVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQI 1174
V++V V+ AT+ LV ++ +PV N +I
Sbjct: 785 SVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEI 821
Score = 282 bits (721), Expect = 4e-75
Identities = 218/695 (31%), Positives = 339/695 (48%), Gaps = 50/695 (7%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSI---D 379
P FP +PEN A + A DPD G G Y L N L++ D
Sbjct: 158 PLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGD 217
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
LI LDRE + + ++V +D G P+ S+T ++ V+V D ND+ PVF++ +
Sbjct: 218 KMPQLI-VQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 276
Query: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSG 499
++ EN G + QL ATD D NA + + F A F ++ +GLI+
Sbjct: 277 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN--LVSNIARRLFHLNATTGLITIKE 334
Query: 500 RVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQ------ 553
+DRE +++L+V ASD G P A V + V D NDN P + RY+
Sbjct: 335 PLDREETPNHKLLVLASDGGLMP----ARAMVLVNVTDVNDNVPSI-DIRYIVNPVNDTV 389
Query: 554 -VREDVRPHTVVLRVTATDRDKDANGLVHY---NIISGNSRGHFAIDSLTGEIQVVAPLD 609
+ E++ +T + +T TD+D D NG V + I R F+ L ++ A LD
Sbjct: 390 VLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL---LENAAYLD 446
Query: 610 FEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
+E+ +EYA+++ A DAG+PPL N + + I+V D ND+ P+F + VS+ EN G
Sbjct: 447 YESTKEYAIKLLAADAGKPPL-NQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQ 505
Query: 670 VIHIQAVDADHGENARLEYSLTGVAPDTP--FVINSATGWVSVSGPLDRESVEHYFFGVE 727
++ + A DAD G NA + Y L PD P F ++ TG ++V LDRE + Y F +
Sbjct: 506 LMKVSATDADSGPNAEINYLL---GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTIL 562
Query: 728 ARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--A 785
A+D+G PPL+++ +V V+++D NDN P FT EY + E+ +V +T D D
Sbjct: 563 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 622
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR---ALHDHC 842
NSA++ I N + F I +Q GV + + D +++ + + A D +
Sbjct: 623 NSAVTLSILDEN--DDFTIDSQTGV--IRPNISFDREKQESYTFYVKAEDGGRVSRSSSA 678
Query: 843 YVHINITDANTHRPVFQSAHYSVSVNEDRPM---GSTIVVISASDDDVGENARITYLL-- 897
V IN+ D N ++PVF Y+ S P G+ + + A D+D G NA + Y +
Sbjct: 679 KVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVG 738
Query: 898 EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVN-DVND 956
+ F ID ++G ITL D D + + + A D G P D+ + V+VN VN+
Sbjct: 739 GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP---DSLFSVVIVNLFVNE 795
Query: 957 NAPQFVASHYTGLVSEDAP--PFTSVLQISATDRD 989
+ + S +AP P T + +S+ D
Sbjct: 796 SVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 830
Score = 269 bits (688), Expect = 3e-71
Identities = 206/666 (30%), Positives = 312/666 (46%), Gaps = 40/666 (6%)
Query: 641 VVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPF- 699
+ DIND+ P+F +T +S+ EN+ + AVD D G N Y L + F
Sbjct: 150 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL--IKSQNIFG 207
Query: 700 --VINSATG----WVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
VI + G + V LDRE + Y V+ D G P S++A + V+V D NDN
Sbjct: 208 LDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNH 267
Query: 754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFA---ISTQGGV 810
P F E + + E+A VGTSV + A D D + N + A
Sbjct: 268 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 327
Query: 811 GLVTLALPLDYKQERYFKLVLTASDRALHD-HCYVHINITDANTHRP------VFQSAHY 863
GL+T+ PLD ++ KL++ ASD L V +N+TD N + P + +
Sbjct: 328 GLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 387
Query: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQ--APLDY 921
+V ++E+ P+ + I +I+ +D D N R+T + +P S L+ A LDY
Sbjct: 388 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDY 447
Query: 922 EDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVL 981
E Y + + A D G P + + + V D NDNAP F S T + E+ P ++
Sbjct: 448 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLM 507
Query: 982 QISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
++SATD D+ N + Y G D +F+++ +G++ V++LDRE Y T A D
Sbjct: 508 KVSATDADSGPNAEINYLL--GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKD 565
Query: 1042 RGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAH 1101
GVPPL + V++ V + D NDN+PVF E++ V EN V IT DPD G N+
Sbjct: 566 NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSA 625
Query: 1102 IMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHVR 1158
+ I++ N + F +D +G + I D E ++ Y V+A VSR A V +
Sbjct: 626 VTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTIN 683
Query: 1159 LVDQNDNSPVLNNFQILFNNYVSN--RSDTFPSGIIGRIPAYDPD--VSDHLFYSFERGN 1214
+VD NDN PV F + NY T P ++ ++ A D D ++ + YS GN
Sbjct: 684 VVDVNDNKPV---FIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 740
Query: 1215 ELQLLVVNQTSGELRLSRKLD-----NNRPLVASMLVTVTDGLHSVTAQCVLRVVIITEE 1269
L ++Q +G + L K D +R LV + + D L SV + +T
Sbjct: 741 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNA 800
Query: 1270 LLANSL 1275
L N L
Sbjct: 801 TLINEL 806
Score = 240 bits (612), Expect = 2e-62
Identities = 172/538 (31%), Positives = 261/538 (48%), Gaps = 32/538 (5%)
Query: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
+ HP F + + +PEN GT+V ++ A D D GE ++ +S + L+++ + LF ++
Sbjct: 265 DNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLN 324
Query: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSP------VF 433
+GLI LDRE H L V A D G + A MV V V D ND+ P +
Sbjct: 325 ATTGLITIKEPLDREETPNHKLLVLASDGG--LMPARAMVLVNVTDVNDNVPSIDIRYIV 382
Query: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDP--- 490
L EN+ I + TD DA N G F + P
Sbjct: 383 NPVNDTVVLSENIPLNTKIALITVTDKDADHN--------GRVTCFTDHEIPFRLRPVFS 434
Query: 491 RSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRY 550
L+ + +D E + Y + + A+D G+ P +SA + I V DENDNAP F++
Sbjct: 435 NQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSA--MLFIKVKDENDNAPVFTQSFV 492
Query: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
+ E+ P +++V+ATD D N ++Y ++ ++ F++D TG + VV LD
Sbjct: 493 TVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDR 551
Query: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
E E +Y I A+D G PPL++N + ++D ND+ P+F ++ V EN P +V
Sbjct: 552 EKEDKYLFTILAKDNGVPPLTSNV-TVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV 610
Query: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
I D D+G+N+ + S+ D F I+S TG + + DRE E Y F V+A D
Sbjct: 611 GLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAED 668
Query: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLN---EDAAVGTSVVSVTAVDRDA-- 785
G S+SA VT+ V+DVNDN+P F + Y+ GT V V AVD D
Sbjct: 669 GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGM 728
Query: 786 NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY 843
N+ + Y I GGNTR+ FAI + G +TL D ++++ A+D D +
Sbjct: 729 NAEVRYSIVGGNTRDLFAIDQE--TGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 784
Score = 84.3 bits (207), Expect = 2e-15
Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 27/260 (10%)
Query: 1013 EPTSGIVRTVRRLDREAVSVY----ELTAYAVDRGVPP--LRTPVSIQVMVQDVNDNAPV 1066
E T I T R+DRE + E Y V+ + P + V I+ +++D+NDNAP+
Sbjct: 100 EDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPL 159
Query: 1067 FPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFS----- 1121
FPA + + ENS + S AVDPD G N Y++++ +F +D+
Sbjct: 160 FPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQ--NIFGLDVIETPEGD 217
Query: 1122 --GELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVHVRLVDQNDNSPVLNNFQILF 1176
+L +LD E + YV+ V+ R A + V + D NDN PV +I
Sbjct: 218 KMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI-- 275
Query: 1177 NNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNEL-----QLLVVNQTSGELRLS 1231
VS + + ++ A D D+ ++ F N + +L +N T+G + +
Sbjct: 276 --EVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 333
Query: 1232 RKLDNNRPLVASMLVTVTDG 1251
LD +LV +DG
Sbjct: 334 EPLDREETPNHKLLVLASDG 353
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 278 bits (712), Expect = 5e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 340
Query: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 341 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 399
Query: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Y+ + E+ G I L++ A D D + I
Sbjct: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Query: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 460 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 512
Query: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 571
Query: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 572 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 631 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 688 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 746
Query: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 747 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 921
Query: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 922 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 981
Query: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 982 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1040
Query: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1041 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1096
Query: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1097 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1154
Query: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
+ F S + R+ A D D ++
Sbjct: 1155 EDARMFTS--VLRVKATDKDTGNY 1176
Score = 274 bits (701), Expect = 9e-73
Identities = 246/817 (30%), Positives = 381/817 (46%), Gaps = 87/817 (10%)
Query: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 474 GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531
P + FEI +G I R++ E Y ++++A+D+ Q R + T +
Sbjct: 193 YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 312 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 371 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
D D + E L + F + T ++++ P+DRE + Y F + A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
Query: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
S V + V+D NDN P F Y + + D G SV+ +TAVD D +N I+Y+
Sbjct: 490 --SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHIN 847
I G + F I+ GL+T+A ++ R + L + A+D A + C V+I
Sbjct: 548 ILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 848 ITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
+ N P F YS+ ++E +G+ ++ + A+D E ITY +E+ PQ F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 661
Query: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--V 962
+ +G +TL LD E Y L ITA D G P T V ++V DVNDNAP F
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
+V E+A F Q+ ATD DA NG+V Y+ N + F I ++G + T
Sbjct: 721 LPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTA 774
Query: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
+L+RE YEL A D V P + +++ + V D++DN+PVF + V V+EN
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVI 1140
G+ + QI A D D G A++ Y+I + F + F+GEL+ L LDYEA QE I
Sbjct: 835 GTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 1141 V-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
+ T P ++ TV V+ D ND PV +
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 927
Score = 249 bits (637), Expect = 2e-65
Identities = 256/977 (26%), Positives = 433/977 (44%), Gaps = 89/977 (9%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376
P F +Y V E GT + A D D G G++ Y + + S + F
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 204
Query: 377 SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432
I +G I L+ E R+++ + A D + R + TT + V V D +D P+
Sbjct: 205 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 264
Query: 433 F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469
F Y+ + E EE PI+ ++A D D PP+ L
Sbjct: 265 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 324
Query: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
VG P F + PR+ +S V+R+ + ++LV++A P P A
Sbjct: 325 SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 379
Query: 530 RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKDANGLV 580
+HI +LDEN+ +P F+ Y + E D T LR+ A D+D +
Sbjct: 380 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 439
Query: 581 HYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638
++ + F + +T + ++ P+D E ++ Y I A D + + + +
Sbjct: 440 ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVN 496
Query: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698
IQV+D ND+ P F + V V + G SVI + AVDAD G N + Y + V
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGD 555
Query: 699 FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV----NDNRP 754
F+IN TG ++++ ++ Y V+A D+ +PP S+ ++V N + P
Sbjct: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQSPP 614
Query: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814
F Y L ++E VG ++++ A DR+ +S I+Y I G+ + F +S G++T
Sbjct: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET--TGILT 671
Query: 815 LALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYSVSVNEDR 871
L LD + + L++TASD +NI TD N + PVF ++SV E+
Sbjct: 672 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
Query: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
+ + + A+D D G N ++ Y L + FRI ++ G+I L+ E + Y L +
Sbjct: 732 A-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 789
Query: 932 TARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAH 991
A D + + T + + V D++DN+P F S YT LV E+ P T++LQI A D D
Sbjct: 790 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
Query: 992 ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AYAVDRGVP 1045
AN V Y ++ E F + P +G + +R LD EA E + A+ + +P
Sbjct: 850 AN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
Query: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG--PNAHIM 1103
P ++ V+V+D+ND PVF ++ V +++ G+ + + A D D P + +
Sbjct: 907 P--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964
Query: 1104 YQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVR 1158
Y++ + P +F+++ SG + ++L+ E + +VV A P++S +
Sbjct: 965 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024
Query: 1159 LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQL 1218
LV P + + G+I ++ + YS GNE
Sbjct: 1025 LVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIVSGNEEDT 1079
Query: 1219 LVVNQTSGELRLSRKLD 1235
+N +G + ++ LD
Sbjct: 1080 FGINNITGVIYVNGPLD 1096
Score = 246 bits (629), Expect = 2e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 390 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 447
Query: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 448 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 503
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 504 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 557
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674
Query: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 675 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 733 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 785
Query: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 786 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845
Query: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 846 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
Query: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 904 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 963
Query: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 964 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
Query: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1079 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
Query: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1198 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
Score = 233 bits (595), Expect = 2e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 669
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 670 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 726
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 727 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 841 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 899 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 1017
Query: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 1018 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1073
Query: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 1074 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1133
Query: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 1134 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
G F +E +G+++T S ++ A D
Sbjct: 1194 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 135 bits (339), Expect = 9e-31
Identities = 151/588 (25%), Positives = 259/588 (44%), Gaps = 77/588 (13%)
Query: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 193 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 987 DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042
D+D + + F N D FT+ T GI R + L DRE Y + A D
Sbjct: 430 DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 485
Query: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
GV PV + + V D NDN P FP ++V V + G V Q+TAVD DEG N I
Sbjct: 486 GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR----ATVHV 1157
Y+I+ G + F ++ +G +T ++ + Y + VQA +AP R TV++
Sbjct: 545 TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
Query: 1158 RLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
++ N+ SP Q++++ +S ++ + A D + D + Y+ E G+ +
Sbjct: 604 EVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAIENGDPQR 659
Query: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
+ +++T+G L L + LD +++T +DG T+ + +V+
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 707
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 278 bits (712), Expect = 5e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 260 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 318
Query: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 319 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 377
Query: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Y+ + E+ G I L++ A D D + I
Sbjct: 378 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 437
Query: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 438 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 490
Query: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 549
Query: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 550 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608
Query: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 609 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 665
Query: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 666 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 724
Query: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 725 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 779
Query: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 780 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 839
Query: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 840 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 899
Query: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 900 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 959
Query: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 960 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1018
Query: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1019 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1074
Query: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1075 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1132
Query: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
+ F S + R+ A D D ++
Sbjct: 1133 EDARMFTS--VLRVKATDKDTGNY 1154
Score = 274 bits (701), Expect = 9e-73
Identities = 246/817 (30%), Positives = 381/817 (46%), Gaps = 87/817 (10%)
Query: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 474 GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531
P + FEI +G I R++ E Y ++++A+D+ Q R + T +
Sbjct: 171 YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 290 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
Query: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 349 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
D D + E L + F + T ++++ P+DRE + Y F + A D
Sbjct: 408 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 467
Query: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
S V + V+D NDN P F Y + + D G SV+ +TAVD D +N I+Y+
Sbjct: 468 --SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 525
Query: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHIN 847
I G + F I+ GL+T+A ++ R + L + A+D A + C V+I
Sbjct: 526 ILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
Query: 848 ITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
+ N P F YS+ ++E +G+ ++ + A+D E ITY +E+ PQ F
Sbjct: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 639
Query: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--V 962
+ +G +TL LD E Y L ITA D G P T V ++V DVNDNAP F
Sbjct: 640 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 698
Query: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
+V E+A F Q+ ATD DA NG+V Y+ N + F I ++G + T
Sbjct: 699 LPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTA 752
Query: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
+L+RE YEL A D V P + +++ + V D++DN+PVF + V V+EN
Sbjct: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
Query: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVI 1140
G+ + QI A D D G A++ Y+I + F + F+GEL+ L LDYEA QE I
Sbjct: 813 GTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
Query: 1141 V-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
+ T P ++ TV V+ D ND PV +
Sbjct: 871 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 905
Score = 249 bits (637), Expect = 2e-65
Identities = 256/977 (26%), Positives = 433/977 (44%), Gaps = 89/977 (9%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376
P F +Y V E GT + A D D G G++ Y + + S + F
Sbjct: 123 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 182
Query: 377 SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432
I +G I L+ E R+++ + A D + R + TT + V V D +D P+
Sbjct: 183 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 242
Query: 433 F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469
F Y+ + E EE PI+ ++A D D PP+ L
Sbjct: 243 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 302
Query: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
VG P F + PR+ +S V+R+ + ++LV++A P P A
Sbjct: 303 SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 357
Query: 530 RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKDANGLV 580
+HI +LDEN+ +P F+ Y + E D T LR+ A D+D +
Sbjct: 358 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 417
Query: 581 HYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638
++ + F + +T + ++ P+D E ++ Y I A D + + + +
Sbjct: 418 ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVN 474
Query: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698
IQV+D ND+ P F + V V + G SVI + AVDAD G N + Y + V
Sbjct: 475 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGD 533
Query: 699 FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV----NDNRP 754
F+IN TG ++++ ++ Y V+A D+ +PP S+ ++V N + P
Sbjct: 534 FIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQSPP 592
Query: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814
F Y L ++E VG ++++ A DR+ +S I+Y I G+ + F +S G++T
Sbjct: 593 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET--TGILT 649
Query: 815 LALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYSVSVNEDR 871
L LD + + L++TASD +NI TD N + PVF ++SV E+
Sbjct: 650 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 709
Query: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
+ + + A+D D G N ++ Y L + FRI ++ G+I L+ E + Y L +
Sbjct: 710 A-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 767
Query: 932 TARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAH 991
A D + + T + + V D++DN+P F S YT LV E+ P T++LQI A D D
Sbjct: 768 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 827
Query: 992 ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AYAVDRGVP 1045
AN V Y ++ E F + P +G + +R LD EA E + A+ + +P
Sbjct: 828 AN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884
Query: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG--PNAHIM 1103
P ++ V+V+D+ND PVF ++ V +++ G+ + + A D D P + +
Sbjct: 885 P--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 942
Query: 1104 YQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVR 1158
Y++ + P +F+++ SG + ++L+ E + +VV A P++S +
Sbjct: 943 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1002
Query: 1159 LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQL 1218
LV P + + G+I ++ + YS GNE
Sbjct: 1003 LVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIVSGNEEDT 1057
Query: 1219 LVVNQTSGELRLSRKLD 1235
+N +G + ++ LD
Sbjct: 1058 FGINNITGVIYVNGPLD 1074
Score = 246 bits (629), Expect = 2e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 368 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 425
Query: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 426 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 481
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 482 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 535
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 536 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595
Query: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 596 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 652
Query: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 653 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710
Query: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 711 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 763
Query: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 764 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 823
Query: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 824 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 881
Query: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 882 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 941
Query: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 942 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1001
Query: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 1002 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1056
Query: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1057 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1115
Query: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1175
Query: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1176 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1232
Score = 233 bits (595), Expect = 2e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 480 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 535
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 536 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 596 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 647
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 648 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 704
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 705 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 759
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 760 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 819 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 876
Query: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 877 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935
Query: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 936 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 995
Query: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 996 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1051
Query: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 1052 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1111
Query: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 1112 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1171
Query: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
G F +E +G+++T S ++ A D
Sbjct: 1172 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Score = 135 bits (339), Expect = 9e-31
Identities = 151/588 (25%), Positives = 259/588 (44%), Gaps = 77/588 (13%)
Query: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 171 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 350 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
Query: 987 DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042
D+D + + F N D FT+ T GI R + L DRE Y + A D
Sbjct: 408 DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 463
Query: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
GV PV + + V D NDN P FP ++V V + G V Q+TAVD DEG N I
Sbjct: 464 GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
Query: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR----ATVHV 1157
Y+I+ G + F ++ +G +T ++ + Y + VQA +AP R TV++
Sbjct: 523 TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 581
Query: 1158 RLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
++ N+ SP Q++++ +S ++ + A D + D + Y+ E G+ +
Sbjct: 582 EVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAIENGDPQR 637
Query: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
+ +++T+G L L + LD +++T +DG T+ + +V+
Sbjct: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 685
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 278 bits (712), Expect = 5e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 340
Query: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 341 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 399
Query: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Y+ + E+ G I L++ A D D + I
Sbjct: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Query: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 460 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 512
Query: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 571
Query: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 572 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 631 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 688 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 746
Query: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 747 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 921
Query: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 922 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 981
Query: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 982 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1040
Query: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1041 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1096
Query: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1097 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1154
Query: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
+ F S + R+ A D D ++
Sbjct: 1155 EDARMFTS--VLRVKATDKDTGNY 1176
Score = 274 bits (701), Expect = 9e-73
Identities = 246/817 (30%), Positives = 381/817 (46%), Gaps = 87/817 (10%)
Query: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 474 GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531
P + FEI +G I R++ E Y ++++A+D+ Q R + T +
Sbjct: 193 YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 312 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 371 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
D D + E L + F + T ++++ P+DRE + Y F + A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
Query: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
S V + V+D NDN P F Y + + D G SV+ +TAVD D +N I+Y+
Sbjct: 490 --SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHIN 847
I G + F I+ GL+T+A ++ R + L + A+D A + C V+I
Sbjct: 548 ILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 848 ITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
+ N P F YS+ ++E +G+ ++ + A+D E ITY +E+ PQ F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 661
Query: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--V 962
+ +G +TL LD E Y L ITA D G P T V ++V DVNDNAP F
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
+V E+A F Q+ ATD DA NG+V Y+ N + F I ++G + T
Sbjct: 721 LPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTA 774
Query: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
+L+RE YEL A D V P + +++ + V D++DN+PVF + V V+EN
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVI 1140
G+ + QI A D D G A++ Y+I + F + F+GEL+ L LDYEA QE I
Sbjct: 835 GTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 1141 V-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
+ T P ++ TV V+ D ND PV +
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 927
Score = 249 bits (637), Expect = 2e-65
Identities = 256/977 (26%), Positives = 433/977 (44%), Gaps = 89/977 (9%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376
P F +Y V E GT + A D D G G++ Y + + S + F
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 204
Query: 377 SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432
I +G I L+ E R+++ + A D + R + TT + V V D +D P+
Sbjct: 205 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 264
Query: 433 F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469
F Y+ + E EE PI+ ++A D D PP+ L
Sbjct: 265 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 324
Query: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
VG P F + PR+ +S V+R+ + ++LV++A P P A
Sbjct: 325 SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 379
Query: 530 RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKDANGLV 580
+HI +LDEN+ +P F+ Y + E D T LR+ A D+D +
Sbjct: 380 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 439
Query: 581 HYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638
++ + F + +T + ++ P+D E ++ Y I A D + + + +
Sbjct: 440 ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVN 496
Query: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698
IQV+D ND+ P F + V V + G SVI + AVDAD G N + Y + V
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGD 555
Query: 699 FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV----NDNRP 754
F+IN TG ++++ ++ Y V+A D+ +PP S+ ++V N + P
Sbjct: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQSPP 614
Query: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814
F Y L ++E VG ++++ A DR+ +S I+Y I G+ + F +S G++T
Sbjct: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET--TGILT 671
Query: 815 LALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYSVSVNEDR 871
L LD + + L++TASD +NI TD N + PVF ++SV E+
Sbjct: 672 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
Query: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
+ + + A+D D G N ++ Y L + FRI ++ G+I L+ E + Y L +
Sbjct: 732 A-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 789
Query: 932 TARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAH 991
A D + + T + + V D++DN+P F S YT LV E+ P T++LQI A D D
Sbjct: 790 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
Query: 992 ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AYAVDRGVP 1045
AN V Y ++ E F + P +G + +R LD EA E + A+ + +P
Sbjct: 850 AN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
Query: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG--PNAHIM 1103
P ++ V+V+D+ND PVF ++ V +++ G+ + + A D D P + +
Sbjct: 907 P--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964
Query: 1104 YQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVR 1158
Y++ + P +F+++ SG + ++L+ E + +VV A P++S +
Sbjct: 965 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024
Query: 1159 LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQL 1218
LV P + + G+I ++ + YS GNE
Sbjct: 1025 LVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIVSGNEEDT 1079
Query: 1219 LVVNQTSGELRLSRKLD 1235
+N +G + ++ LD
Sbjct: 1080 FGINNITGVIYVNGPLD 1096
Score = 246 bits (629), Expect = 2e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 390 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 447
Query: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 448 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 503
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 504 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 557
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674
Query: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 675 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 733 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 785
Query: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 786 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845
Query: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 846 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
Query: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 904 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 963
Query: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 964 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
Query: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1079 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
Query: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1198 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
Score = 233 bits (595), Expect = 2e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 669
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 670 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 726
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 727 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 841 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 899 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 1017
Query: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 1018 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1073
Query: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 1074 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1133
Query: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 1134 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
G F +E +G+++T S ++ A D
Sbjct: 1194 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 135 bits (339), Expect = 9e-31
Identities = 151/588 (25%), Positives = 259/588 (44%), Gaps = 77/588 (13%)
Query: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 193 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 987 DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042
D+D + + F N D FT+ T GI R + L DRE Y + A D
Sbjct: 430 DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 485
Query: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
GV PV + + V D NDN P FP ++V V + G V Q+TAVD DEG N I
Sbjct: 486 GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR----ATVHV 1157
Y+I+ G + F ++ +G +T ++ + Y + VQA +AP R TV++
Sbjct: 545 TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
Query: 1158 RLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
++ N+ SP Q++++ +S ++ + A D + D + Y+ E G+ +
Sbjct: 604 EVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAIENGDPQR 659
Query: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
+ +++T+G L L + LD +++T +DG T+ + +V+
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 707
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 278 bits (712), Expect = 5e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 287 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 345
Query: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 346 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 404
Query: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Y+ + E+ G I L++ A D D + I
Sbjct: 405 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 464
Query: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 465 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 517
Query: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 518 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 576
Query: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 577 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 635
Query: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 636 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 692
Query: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 693 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 751
Query: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 752 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 806
Query: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 807 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 866
Query: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 867 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 926
Query: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 927 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 986
Query: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 987 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1045
Query: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1046 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1101
Query: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1102 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1159
Query: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
+ F S + R+ A D D ++
Sbjct: 1160 EDARMFTS--VLRVKATDKDTGNY 1181
Score = 274 bits (701), Expect = 9e-73
Identities = 246/817 (30%), Positives = 381/817 (46%), Gaps = 87/817 (10%)
Query: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 474 GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531
P + FEI +G I R++ E Y ++++A+D+ Q R + T +
Sbjct: 198 YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 317 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375
Query: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 376 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
D D + E L + F + T ++++ P+DRE + Y F + A D
Sbjct: 435 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 494
Query: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
S V + V+D NDN P F Y + + D G SV+ +TAVD D +N I+Y+
Sbjct: 495 --SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552
Query: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHIN 847
I G + F I+ GL+T+A ++ R + L + A+D A + C V+I
Sbjct: 553 ILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 609
Query: 848 ITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
+ N P F YS+ ++E +G+ ++ + A+D E ITY +E+ PQ F
Sbjct: 610 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 666
Query: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--V 962
+ +G +TL LD E Y L ITA D G P T V ++V DVNDNAP F
Sbjct: 667 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 725
Query: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
+V E+A F Q+ ATD DA NG+V Y+ N + F I ++G + T
Sbjct: 726 LPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTA 779
Query: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
+L+RE YEL A D V P + +++ + V D++DN+PVF + V V+EN
Sbjct: 780 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 839
Query: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVI 1140
G+ + QI A D D G A++ Y+I + F + F+GEL+ L LDYEA QE I
Sbjct: 840 GTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 897
Query: 1141 V-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
+ T P ++ TV V+ D ND PV +
Sbjct: 898 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 932
Score = 249 bits (637), Expect = 2e-65
Identities = 256/977 (26%), Positives = 433/977 (44%), Gaps = 89/977 (9%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376
P F +Y V E GT + A D D G G++ Y + + S + F
Sbjct: 150 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 209
Query: 377 SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432
I +G I L+ E R+++ + A D + R + TT + V V D +D P+
Sbjct: 210 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 269
Query: 433 F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469
F Y+ + E EE PI+ ++A D D PP+ L
Sbjct: 270 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 329
Query: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
VG P F + PR+ +S V+R+ + ++LV++A P P A
Sbjct: 330 SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 384
Query: 530 RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKDANGLV 580
+HI +LDEN+ +P F+ Y + E D T LR+ A D+D +
Sbjct: 385 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 444
Query: 581 HYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638
++ + F + +T + ++ P+D E ++ Y I A D + + + +
Sbjct: 445 ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVN 501
Query: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698
IQV+D ND+ P F + V V + G SVI + AVDAD G N + Y + V
Sbjct: 502 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGD 560
Query: 699 FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV----NDNRP 754
F+IN TG ++++ ++ Y V+A D+ +PP S+ ++V N + P
Sbjct: 561 FIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQSPP 619
Query: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814
F Y L ++E VG ++++ A DR+ +S I+Y I G+ + F +S G++T
Sbjct: 620 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET--TGILT 676
Query: 815 LALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYSVSVNEDR 871
L LD + + L++TASD +NI TD N + PVF ++SV E+
Sbjct: 677 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 736
Query: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
+ + + A+D D G N ++ Y L + FRI ++ G+I L+ E + Y L +
Sbjct: 737 A-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 794
Query: 932 TARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAH 991
A D + + T + + V D++DN+P F S YT LV E+ P T++LQI A D D
Sbjct: 795 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 854
Query: 992 ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AYAVDRGVP 1045
AN V Y ++ E F + P +G + +R LD EA E + A+ + +P
Sbjct: 855 AN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 911
Query: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG--PNAHIM 1103
P ++ V+V+D+ND PVF ++ V +++ G+ + + A D D P + +
Sbjct: 912 P--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 969
Query: 1104 YQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVR 1158
Y++ + P +F+++ SG + ++L+ E + +VV A P++S +
Sbjct: 970 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1029
Query: 1159 LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQL 1218
LV P + + G+I ++ + YS GNE
Sbjct: 1030 LVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIVSGNEEDT 1084
Query: 1219 LVVNQTSGELRLSRKLD 1235
+N +G + ++ LD
Sbjct: 1085 FGINNITGVIYVNGPLD 1101
Score = 246 bits (629), Expect = 2e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 395 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 452
Query: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 453 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 508
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 509 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 562
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 563 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 622
Query: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 623 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 679
Query: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 680 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 737
Query: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 738 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 790
Query: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 791 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 850
Query: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 851 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 908
Query: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 909 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 968
Query: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 969 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1028
Query: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 1029 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1083
Query: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1084 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1142
Query: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1143 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1202
Query: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1203 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1259
Score = 233 bits (595), Expect = 2e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 507 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 562
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 563 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 622
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 623 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 674
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 675 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 731
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 732 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 786
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 787 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 845
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 846 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 903
Query: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 904 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 962
Query: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 963 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 1022
Query: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 1023 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1078
Query: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 1079 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1138
Query: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 1139 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1198
Query: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
G F +E +G+++T S ++ A D
Sbjct: 1199 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Score = 135 bits (339), Expect = 9e-31
Identities = 151/588 (25%), Positives = 259/588 (44%), Gaps = 77/588 (13%)
Query: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 198 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 377 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
Query: 987 DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042
D+D + + F N D FT+ T GI R + L DRE Y + A D
Sbjct: 435 DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 490
Query: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
GV PV + + V D NDN P FP ++V V + G V Q+TAVD DEG N I
Sbjct: 491 GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 549
Query: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR----ATVHV 1157
Y+I+ G + F ++ +G +T ++ + Y + VQA +AP R TV++
Sbjct: 550 TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 608
Query: 1158 RLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
++ N+ SP Q++++ +S ++ + A D + D + Y+ E G+ +
Sbjct: 609 EVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAIENGDPQR 664
Query: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
+ +++T+G L L + LD +++T +DG T+ + +V+
Sbjct: 665 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 712
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 278 bits (712), Expect = 5e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 340
Query: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 341 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 399
Query: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Y+ + E+ G I L++ A D D + I
Sbjct: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Query: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 460 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 512
Query: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 571
Query: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 572 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 631 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 688 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 746
Query: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 747 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 921
Query: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 922 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 981
Query: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 982 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1040
Query: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1041 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1096
Query: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1097 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1154
Query: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
+ F S + R+ A D D ++
Sbjct: 1155 EDARMFTS--VLRVKATDKDTGNY 1176
Score = 274 bits (701), Expect = 9e-73
Identities = 246/817 (30%), Positives = 381/817 (46%), Gaps = 87/817 (10%)
Query: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 474 GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531
P + FEI +G I R++ E Y ++++A+D+ Q R + T +
Sbjct: 193 YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 312 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 371 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
D D + E L + F + T ++++ P+DRE + Y F + A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
Query: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
S V + V+D NDN P F Y + + D G SV+ +TAVD D +N I+Y+
Sbjct: 490 --SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHIN 847
I G + F I+ GL+T+A ++ R + L + A+D A + C V+I
Sbjct: 548 ILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 848 ITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
+ N P F YS+ ++E +G+ ++ + A+D E ITY +E+ PQ F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 661
Query: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--V 962
+ +G +TL LD E Y L ITA D G P T V ++V DVNDNAP F
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
+V E+A F Q+ ATD DA NG+V Y+ N + F I ++G + T
Sbjct: 721 LPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTA 774
Query: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
+L+RE YEL A D V P + +++ + V D++DN+PVF + V V+EN
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVI 1140
G+ + QI A D D G A++ Y+I + F + F+GEL+ L LDYEA QE I
Sbjct: 835 GTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 1141 V-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
+ T P ++ TV V+ D ND PV +
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 927
Score = 249 bits (637), Expect = 2e-65
Identities = 256/977 (26%), Positives = 433/977 (44%), Gaps = 89/977 (9%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376
P F +Y V E GT + A D D G G++ Y + + S + F
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 204
Query: 377 SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432
I +G I L+ E R+++ + A D + R + TT + V V D +D P+
Sbjct: 205 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 264
Query: 433 F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469
F Y+ + E EE PI+ ++A D D PP+ L
Sbjct: 265 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 324
Query: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
VG P F + PR+ +S V+R+ + ++LV++A P P A
Sbjct: 325 SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 379
Query: 530 RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKDANGLV 580
+HI +LDEN+ +P F+ Y + E D T LR+ A D+D +
Sbjct: 380 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 439
Query: 581 HYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638
++ + F + +T + ++ P+D E ++ Y I A D + + + +
Sbjct: 440 ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVN 496
Query: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698
IQV+D ND+ P F + V V + G SVI + AVDAD G N + Y + V
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGD 555
Query: 699 FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV----NDNRP 754
F+IN TG ++++ ++ Y V+A D+ +PP S+ ++V N + P
Sbjct: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQSPP 614
Query: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814
F Y L ++E VG ++++ A DR+ +S I+Y I G+ + F +S G++T
Sbjct: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET--TGILT 671
Query: 815 LALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYSVSVNEDR 871
L LD + + L++TASD +NI TD N + PVF ++SV E+
Sbjct: 672 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
Query: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
+ + + A+D D G N ++ Y L + FRI ++ G+I L+ E + Y L +
Sbjct: 732 A-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 789
Query: 932 TARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAH 991
A D + + T + + V D++DN+P F S YT LV E+ P T++LQI A D D
Sbjct: 790 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
Query: 992 ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AYAVDRGVP 1045
AN V Y ++ E F + P +G + +R LD EA E + A+ + +P
Sbjct: 850 AN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
Query: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG--PNAHIM 1103
P ++ V+V+D+ND PVF ++ V +++ G+ + + A D D P + +
Sbjct: 907 P--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964
Query: 1104 YQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVR 1158
Y++ + P +F+++ SG + ++L+ E + +VV A P++S +
Sbjct: 965 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024
Query: 1159 LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQL 1218
LV P + + G+I ++ + YS GNE
Sbjct: 1025 LVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIVSGNEEDT 1079
Query: 1219 LVVNQTSGELRLSRKLD 1235
+N +G + ++ LD
Sbjct: 1080 FGINNITGVIYVNGPLD 1096
Score = 246 bits (629), Expect = 2e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 390 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 447
Query: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 448 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 503
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 504 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 557
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674
Query: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 675 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 733 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 785
Query: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 786 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845
Query: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 846 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
Query: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 904 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 963
Query: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 964 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
Query: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1079 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
Query: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1198 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
Score = 233 bits (595), Expect = 2e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 669
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 670 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 726
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 727 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 841 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 899 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 1017
Query: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 1018 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1073
Query: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 1074 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1133
Query: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 1134 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
G F +E +G+++T S ++ A D
Sbjct: 1194 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 135 bits (339), Expect = 9e-31
Identities = 151/588 (25%), Positives = 259/588 (44%), Gaps = 77/588 (13%)
Query: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 193 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 987 DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042
D+D + + F N D FT+ T GI R + L DRE Y + A D
Sbjct: 430 DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 485
Query: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
GV PV + + V D NDN P FP ++V V + G V Q+TAVD DEG N I
Sbjct: 486 GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR----ATVHV 1157
Y+I+ G + F ++ +G +T ++ + Y + VQA +AP R TV++
Sbjct: 545 TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
Query: 1158 RLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
++ N+ SP Q++++ +S ++ + A D + D + Y+ E G+ +
Sbjct: 604 EVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAIENGDPQR 659
Query: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
+ +++T+G L L + LD +++T +DG T+ + +V+
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 707
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 278 bits (712), Expect = 5e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 260 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 318
Query: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 319 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 377
Query: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Y+ + E+ G I L++ A D D + I
Sbjct: 378 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 437
Query: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 438 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 490
Query: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 549
Query: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 550 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608
Query: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 609 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 665
Query: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 666 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 724
Query: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 725 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 779
Query: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 780 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 839
Query: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 840 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 899
Query: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 900 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 959
Query: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 960 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1018
Query: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1019 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1074
Query: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1075 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1132
Query: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
+ F S + R+ A D D ++
Sbjct: 1133 EDARMFTS--VLRVKATDKDTGNY 1154
Score = 274 bits (701), Expect = 9e-73
Identities = 246/817 (30%), Positives = 381/817 (46%), Gaps = 87/817 (10%)
Query: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 474 GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531
P + FEI +G I R++ E Y ++++A+D+ Q R + T +
Sbjct: 171 YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 290 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
Query: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 349 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
D D + E L + F + T ++++ P+DRE + Y F + A D
Sbjct: 408 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 467
Query: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
S V + V+D NDN P F Y + + D G SV+ +TAVD D +N I+Y+
Sbjct: 468 --SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 525
Query: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHIN 847
I G + F I+ GL+T+A ++ R + L + A+D A + C V+I
Sbjct: 526 ILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
Query: 848 ITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
+ N P F YS+ ++E +G+ ++ + A+D E ITY +E+ PQ F
Sbjct: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 639
Query: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--V 962
+ +G +TL LD E Y L ITA D G P T V ++V DVNDNAP F
Sbjct: 640 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 698
Query: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
+V E+A F Q+ ATD DA NG+V Y+ N + F I ++G + T
Sbjct: 699 LPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTA 752
Query: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
+L+RE YEL A D V P + +++ + V D++DN+PVF + V V+EN
Sbjct: 753 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 812
Query: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVI 1140
G+ + QI A D D G A++ Y+I + F + F+GEL+ L LDYEA QE I
Sbjct: 813 GTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 870
Query: 1141 V-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
+ T P ++ TV V+ D ND PV +
Sbjct: 871 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 905
Score = 249 bits (637), Expect = 2e-65
Identities = 256/977 (26%), Positives = 433/977 (44%), Gaps = 89/977 (9%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376
P F +Y V E GT + A D D G G++ Y + + S + F
Sbjct: 123 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 182
Query: 377 SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432
I +G I L+ E R+++ + A D + R + TT + V V D +D P+
Sbjct: 183 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 242
Query: 433 F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469
F Y+ + E EE PI+ ++A D D PP+ L
Sbjct: 243 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 302
Query: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
VG P F + PR+ +S V+R+ + ++LV++A P P A
Sbjct: 303 SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 357
Query: 530 RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKDANGLV 580
+HI +LDEN+ +P F+ Y + E D T LR+ A D+D +
Sbjct: 358 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 417
Query: 581 HYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638
++ + F + +T + ++ P+D E ++ Y I A D + + + +
Sbjct: 418 ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVN 474
Query: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698
IQV+D ND+ P F + V V + G SVI + AVDAD G N + Y + V
Sbjct: 475 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGD 533
Query: 699 FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV----NDNRP 754
F+IN TG ++++ ++ Y V+A D+ +PP S+ ++V N + P
Sbjct: 534 FIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQSPP 592
Query: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814
F Y L ++E VG ++++ A DR+ +S I+Y I G+ + F +S G++T
Sbjct: 593 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET--TGILT 649
Query: 815 LALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYSVSVNEDR 871
L LD + + L++TASD +NI TD N + PVF ++SV E+
Sbjct: 650 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 709
Query: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
+ + + A+D D G N ++ Y L + FRI ++ G+I L+ E + Y L +
Sbjct: 710 A-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 767
Query: 932 TARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAH 991
A D + + T + + V D++DN+P F S YT LV E+ P T++LQI A D D
Sbjct: 768 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 827
Query: 992 ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AYAVDRGVP 1045
AN V Y ++ E F + P +G + +R LD EA E + A+ + +P
Sbjct: 828 AN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 884
Query: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG--PNAHIM 1103
P ++ V+V+D+ND PVF ++ V +++ G+ + + A D D P + +
Sbjct: 885 P--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 942
Query: 1104 YQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVR 1158
Y++ + P +F+++ SG + ++L+ E + +VV A P++S +
Sbjct: 943 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1002
Query: 1159 LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQL 1218
LV P + + G+I ++ + YS GNE
Sbjct: 1003 LVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIVSGNEEDT 1057
Query: 1219 LVVNQTSGELRLSRKLD 1235
+N +G + ++ LD
Sbjct: 1058 FGINNITGVIYVNGPLD 1074
Score = 246 bits (629), Expect = 2e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 368 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 425
Query: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 426 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 481
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 482 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 535
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 536 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595
Query: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 596 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 652
Query: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 653 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710
Query: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 711 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 763
Query: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 764 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 823
Query: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 824 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 881
Query: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 882 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 941
Query: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 942 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1001
Query: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 1002 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1056
Query: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1057 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1115
Query: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1175
Query: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1176 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1232
Score = 233 bits (595), Expect = 2e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 480 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 535
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 536 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 596 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 647
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 648 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 704
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 705 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 759
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 760 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 819 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 876
Query: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 877 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935
Query: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 936 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 995
Query: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 996 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1051
Query: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 1052 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1111
Query: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 1112 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1171
Query: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
G F +E +G+++T S ++ A D
Sbjct: 1172 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Score = 135 bits (339), Expect = 9e-31
Identities = 151/588 (25%), Positives = 259/588 (44%), Gaps = 77/588 (13%)
Query: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 171 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 350 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
Query: 987 DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042
D+D + + F N D FT+ T GI R + L DRE Y + A D
Sbjct: 408 DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 463
Query: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
GV PV + + V D NDN P FP ++V V + G V Q+TAVD DEG N I
Sbjct: 464 GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
Query: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR----ATVHV 1157
Y+I+ G + F ++ +G +T ++ + Y + VQA +AP R TV++
Sbjct: 523 TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 581
Query: 1158 RLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
++ N+ SP Q++++ +S ++ + A D + D + Y+ E G+ +
Sbjct: 582 EVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAIENGDPQR 637
Query: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
+ +++T+G L L + LD +++T +DG T+ + +V+
Sbjct: 638 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 685
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 278 bits (712), Expect = 5e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 245 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 303
Query: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 304 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 362
Query: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Y+ + E+ G I L++ A D D + I
Sbjct: 363 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 422
Query: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 423 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 475
Query: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 476 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 534
Query: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 535 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 593
Query: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 594 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 650
Query: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 651 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 709
Query: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 710 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 764
Query: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 765 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 824
Query: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 825 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 884
Query: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 885 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 944
Query: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 945 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1003
Query: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1004 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1059
Query: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1060 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1117
Query: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
+ F S + R+ A D D ++
Sbjct: 1118 EDARMFTS--VLRVKATDKDTGNY 1139
Score = 256 bits (654), Expect = 3e-67
Identities = 237/800 (29%), Positives = 371/800 (46%), Gaps = 90/800 (11%)
Query: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 474 GPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHI 533
P DP + ++ + L V+ D G + GP +
Sbjct: 193 YNPD-----------DP-----DRAQNLNERRTTTTTLTVDVLD-GDDLGPMFLPC---V 232
Query: 534 TVLDENDNAPQFSEKRYVAQVR--EDVRPHTVVLRVTATDRDK------DANGLVHYNII 585
V + D P + + + ++R E++ P V + A D+D+ D G++ Y+I+
Sbjct: 233 LVPNTRDCRP-LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSIL 290
Query: 586 SGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVV 642
G + F + T E+ ++ P++ + +++ L I+A+ PL GL I+++
Sbjct: 291 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEIL 349
Query: 643 DINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAVDADHGENARLEYSLTGV 693
D N+ P F +Q +LE+AP+G ++ + I A+D D + E L
Sbjct: 350 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLN 409
Query: 694 APDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVND 751
+ F + T ++++ P+DRE + Y F + A D S V + V+D ND
Sbjct: 410 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDAND 467
Query: 752 NRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGG 809
N P F Y + + D G SV+ +TAVD D +N I+Y+I G + F I+
Sbjct: 468 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT-- 524
Query: 810 VGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHINITDANTHRPV-FQSAHY 863
GL+T+A ++ R + L + A+D A + C V+I + N P F Y
Sbjct: 525 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 584
Query: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGAITLQAPLDY 921
S+ ++E +G+ ++ + A+D E ITY +E+ PQ F + +G +TL LD
Sbjct: 585 SLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDR 641
Query: 922 EDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--VASHYTGLVSEDAPPFTS 979
E Y L ITA D G P T V ++V DVNDNAP F +V E+A F
Sbjct: 642 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG 700
Query: 980 VLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA 1039
Q+ ATD DA NG+V Y+ N + F I ++G + T +L+RE YEL A
Sbjct: 701 --QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTAVKLNREVRDYYELVVVA 754
Query: 1040 VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPN 1099
D V P + +++ + V D++DN+PVF + V V+EN G+ + QI A D D G
Sbjct: 755 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG-- 812
Query: 1100 AHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVIV-------VQATSAPLV 1150
A++ Y+I + F + F+GEL+ L LDYEA QE I + T P +
Sbjct: 813 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 872
Query: 1151 SRATVHVRLVDQNDNSPVLN 1170
+ TV V+ D ND PV +
Sbjct: 873 ATVTVIVK--DMNDYPPVFS 890
Score = 246 bits (629), Expect = 2e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 353 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 410
Query: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 411 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 466
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 467 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 520
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 521 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 580
Query: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 581 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 637
Query: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 638 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
Query: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 696 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 748
Query: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 749 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 808
Query: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 809 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 866
Query: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 867 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 926
Query: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 927 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 986
Query: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 987 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1041
Query: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1042 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1100
Query: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1101 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1160
Query: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1161 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1217
Score = 239 bits (611), Expect = 3e-62
Identities = 233/878 (26%), Positives = 396/878 (45%), Gaps = 79/878 (8%)
Query: 412 RLSATTMVAVTVADRNDHSPVF------------EQAQYRETLRE--NVEEGYPIL---Q 454
R + TT + V V D +D P+F Y+ + E EE PI+
Sbjct: 207 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 266
Query: 455 LRATDGDA---PPNAN---LRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMES 508
++A D D PP+ L VG P F + PR+ +S V+R+ +
Sbjct: 267 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQK 323
Query: 509 YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRE---------DVR 559
++LV++A P P A +HI +LDEN+ +P F+ Y + E D
Sbjct: 324 FDLVIKAEQDNGHPLP--AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSL 381
Query: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYA 617
T LR+ A D+D + ++ + F + +T + ++ P+D E ++ Y
Sbjct: 382 NLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 441
Query: 618 LRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVD 677
I A D + + + +IQV+D ND+ P F + V V + G SVI + AVD
Sbjct: 442 FSITAFDGVQ---ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 498
Query: 678 ADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLS 737
AD G N + Y + V F+IN TG ++++ ++ Y V+A D+ +PP
Sbjct: 499 ADEGSNGEITYEIL-VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAE 556
Query: 738 ASASVTVTVLDV----NDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQI 793
S+ ++V N + P F Y L ++E VG ++++ A DR+ +S I+Y I
Sbjct: 557 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAI 615
Query: 794 TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDA 851
G+ + F +S G++TL LD + + L++TASD +NI TD
Sbjct: 616 ENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDV 673
Query: 852 NTHRPVFQS-AHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADS 910
N + PVF ++SV E+ + + + A+D D G N ++ Y L + FRI ++
Sbjct: 674 NDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 731
Query: 911 GAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLV 970
G+I L+ E + Y L + A D + + T + + V D++DN+P F S YT LV
Sbjct: 732 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 791
Query: 971 SEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAV 1030
E+ P T++LQI A D D AN V Y ++ E F + P +G + +R LD EA
Sbjct: 792 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAF 848
Query: 1031 SVYELT------AYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGS 1084
E + A+ + +PP ++ V+V+D+ND PVF ++ V +++ G+
Sbjct: 849 PDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 906
Query: 1085 VVAQITAVDPDEG--PNAHIMYQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYV 1139
+ + A D D P + + Y++ + P +F+++ SG + ++L+ E +
Sbjct: 907 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 966
Query: 1140 IVVQA--TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPA 1197
+VV A P++S + LV P + + G+I
Sbjct: 967 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA- 1025
Query: 1198 YDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLD 1235
++ + YS GNE +N +G + ++ LD
Sbjct: 1026 ----INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1059
Score = 233 bits (595), Expect = 2e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 465 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 520
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 521 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 580
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 581 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 632
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 633 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 689
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 690 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 744
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 745 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 804 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 861
Query: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 862 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 920
Query: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 921 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 980
Query: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 981 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1036
Query: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 1037 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1096
Query: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 1097 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1156
Query: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
G F +E +G+++T S ++ A D
Sbjct: 1157 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1189
Score = 218 bits (555), Expect = 8e-56
Identities = 216/797 (27%), Positives = 348/797 (43%), Gaps = 104/797 (13%)
Query: 495 ISTSGRV-DREH-MESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA 552
++++GRV DR+ M + +VV+ ++ G V I V D NDN+P F + Y A
Sbjct: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGT-IIYHEVRIVVRDRNDNSPTFKHESYYA 154
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E T + + SG++ D G+I
Sbjct: 155 TVNELTPVGTTI-----------------FTGFSGDNGATDIDDGPNGQI---------- 187
Query: 613 EREYALRIRAQDAGRPPLSN----NTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGH 668
EY ++ D R N T ++ V+D +D P+F+ + + PL +
Sbjct: 188 --EYVIQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTY 245
Query: 669 SVI-----------------HIQAVDADH-----GENARLEYS-LTGVAPDTP--FVINS 703
IQA+D D + + YS L G D P F ++
Sbjct: 246 QAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHP 305
Query: 704 ATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHL 763
T +S+ P++R+ + + ++A PL A A + + +LD N+ P FTM Y
Sbjct: 306 RTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQG 365
Query: 764 RLNEDAAVG---------TSVVSVTAVDRDANSA--ISYQITGGNTRNRFAISTQGGVGL 812
+ E A VG TS + + A+D+D + + + F ++ G
Sbjct: 366 YILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRY 425
Query: 813 VTLALPLDYKQERYFKLVLTASDRALH-DHCYVHINITDANTHRPVFQSAHYSVSVNEDR 871
+TL P+D ++++ + +TA D + V+I + DAN + P F Y V V D
Sbjct: 426 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 485
Query: 872 PMGSTIVVISASDDDVGENARITY-LLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLA 930
G +++ ++A D D G N ITY +L F I+ +G IT+ ++ TY L
Sbjct: 486 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 545
Query: 931 ITARDNGIPQKAD----TTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISAT 986
+ A DN P + T Y+EV+ + N + P+F Y+ +SE +L + AT
Sbjct: 546 VQAADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 604
Query: 987 DRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPP 1046
DR+ + + Y +NG D F + T+GI+ + LDRE+ Y L A D G P
Sbjct: 605 DREGDS---ITYAIENG-DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 659
Query: 1047 LRTPVSIQVMVQDVNDNAPVF----PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
+ ++ ++V DVNDNAPVF P V + N+ VG Q+ A DPD G N +
Sbjct: 660 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQV 715
Query: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA---PLVSRATVHVRL 1159
Y + GN LF++ +G + + L+ E R Y +VV AT P S T+ +++
Sbjct: 716 HYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKV 772
Query: 1160 VDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDVSDHLFYSFERGNELQL 1218
+D +DNSPV N + Y + P+G I +I A D D+ ++ Y
Sbjct: 773 LDIDDNSPVFTN-----STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHF 827
Query: 1219 LVVNQTSGELRLSRKLD 1235
++ +GEL L R LD
Sbjct: 828 FALHPFTGELSLLRSLD 844
Score = 124 bits (310), Expect = 2e-27
Identities = 149/563 (26%), Positives = 242/563 (42%), Gaps = 64/563 (11%)
Query: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 795 GGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHINITDANT 853
N + T L +D VL D + C + N D
Sbjct: 193 Y-NPDDPDRAQNLNERRTTTTTLTVD---------VLDGDDLGPMFLPCVLVPNTRDC-- 240
Query: 854 HRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDD-----VGENARITYLLEDNLPQ---- 903
RP+ +Q+A + E+ I A D D + I Y + P+
Sbjct: 241 -RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 299
Query: 904 -FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDNGIPQKADT-TYVEVMVNDVNDNAPQ 960
F + + ++L P++ + + L I A +DNG P A ++E++ D N+ +P
Sbjct: 300 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSPY 357
Query: 961 FVASHYTGLVSEDAPP---------FTSVLQISATDRDAHANGRVQ-YTFQNGEDGDGDF 1010
F Y G + E AP TS L+I A D+D + + F N D F
Sbjct: 358 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLN--DYTSVF 415
Query: 1011 TIEPTSGIVRTVRRL---DREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF 1067
T+ T GI R + L DRE Y + A D GV PV + + V D NDN P F
Sbjct: 416 TVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTF 472
Query: 1068 PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL 1127
P ++V V + G V Q+TAVD DEG N I Y+I+ G + F ++ +G +T
Sbjct: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIA 531
Query: 1128 IDLDYEARQEYVIVVQAT-SAPLVSR----ATVHVRLVDQNDNSPVLNNFQILFNNYVSN 1182
++ + Y + VQA +AP R TV++ ++ N+ SP Q++++ +S
Sbjct: 532 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP-QLMYSLEISE 590
Query: 1183 RSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVA 1242
++ + A D + D + Y+ E G+ ++ +++T+G L L + LD
Sbjct: 591 AMRV--GAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRY 647
Query: 1243 SMLVTVTDGLHSVTAQCVLRVVI 1265
+++T +DG T+ + +V+
Sbjct: 648 ILIITASDGRPDGTSTATVNIVV 670
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 278 bits (712), Expect = 5e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 340
Query: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 341 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 399
Query: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Y+ + E+ G I L++ A D D + I
Sbjct: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Query: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 460 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 512
Query: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 571
Query: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 572 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 631 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 688 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 746
Query: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 747 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
Query: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
Query: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 921
Query: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 922 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 981
Query: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 982 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1040
Query: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1041 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1096
Query: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1097 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1154
Query: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
+ F S + R+ A D D ++
Sbjct: 1155 EDARMFTS--VLRVKATDKDTGNY 1176
Score = 274 bits (701), Expect = 9e-73
Identities = 246/817 (30%), Positives = 381/817 (46%), Gaps = 87/817 (10%)
Query: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 474 GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531
P + FEI +G I R++ E Y ++++A+D+ Q R + T +
Sbjct: 193 YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 312 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 371 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 677 DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
D D + E L + F + T ++++ P+DRE + Y F + A D
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
Query: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
S V + V+D NDN P F Y + + D G SV+ +TAVD D +N I+Y+
Sbjct: 490 --SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHIN 847
I G + F I+ GL+T+A ++ R + L + A+D A + C V+I
Sbjct: 548 ILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 848 ITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
+ N P F YS+ ++E +G+ ++ + A+D E ITY +E+ PQ F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 661
Query: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--V 962
+ +G +TL LD E Y L ITA D G P T V ++V DVNDNAP F
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
+V E+A F Q+ ATD DA NG+V Y+ N + F I ++G + T
Sbjct: 721 LPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTA 774
Query: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
+L+RE YEL A D V P + +++ + V D++DN+PVF + V V+EN
Sbjct: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
Query: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVI 1140
G+ + QI A D D G A++ Y+I + F + F+GEL+ L LDYEA QE I
Sbjct: 835 GTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
Query: 1141 V-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
+ T P ++ TV V+ D ND PV +
Sbjct: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 927
Score = 249 bits (637), Expect = 2e-65
Identities = 256/977 (26%), Positives = 433/977 (44%), Gaps = 89/977 (9%)
Query: 323 PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376
P F +Y V E GT + A D D G G++ Y + + S + F
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 204
Query: 377 SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432
I +G I L+ E R+++ + A D + R + TT + V V D +D P+
Sbjct: 205 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 264
Query: 433 F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469
F Y+ + E EE PI+ ++A D D PP+ L
Sbjct: 265 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 324
Query: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
VG P F + PR+ +S V+R+ + ++LV++A P P A
Sbjct: 325 SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 379
Query: 530 RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKDANGLV 580
+HI +LDEN+ +P F+ Y + E D T LR+ A D+D +
Sbjct: 380 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 439
Query: 581 HYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638
++ + F + +T + ++ P+D E ++ Y I A D + + + +
Sbjct: 440 ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVN 496
Query: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698
IQV+D ND+ P F + V V + G SVI + AVDAD G N + Y + V
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGD 555
Query: 699 FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV----NDNRP 754
F+IN TG ++++ ++ Y V+A D+ +PP S+ ++V N + P
Sbjct: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQSPP 614
Query: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814
F Y L ++E VG ++++ A DR+ +S I+Y I G+ + F +S G++T
Sbjct: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET--TGILT 671
Query: 815 LALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYSVSVNEDR 871
L LD + + L++TASD +NI TD N + PVF ++SV E+
Sbjct: 672 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
Query: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
+ + + A+D D G N ++ Y L + FRI ++ G+I L+ E + Y L +
Sbjct: 732 A-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 789
Query: 932 TARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAH 991
A D + + T + + V D++DN+P F S YT LV E+ P T++LQI A D D
Sbjct: 790 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
Query: 992 ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AYAVDRGVP 1045
AN V Y ++ E F + P +G + +R LD EA E + A+ + +P
Sbjct: 850 AN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
Query: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG--PNAHIM 1103
P ++ V+V+D+ND PVF ++ V +++ G+ + + A D D P + +
Sbjct: 907 P--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964
Query: 1104 YQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVR 1158
Y++ + P +F+++ SG + ++L+ E + +VV A P++S +
Sbjct: 965 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024
Query: 1159 LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQL 1218
LV P + + G+I ++ + YS GNE
Sbjct: 1025 LVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIVSGNEEDT 1079
Query: 1219 LVVNQTSGELRLSRKLD 1235
+N +G + ++ LD
Sbjct: 1080 FGINNITGVIYVNGPLD 1096
Score = 246 bits (629), Expect = 2e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 390 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 447
Query: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 448 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 503
Query: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 504 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 557
Query: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674
Query: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 675 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 733 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 785
Query: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 786 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845
Query: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 846 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
Query: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 904 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 963
Query: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 964 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
Query: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1079 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
Query: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
Query: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1198 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
Score = 233 bits (595), Expect = 2e-60
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557
Query: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 669
Query: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 670 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 726
Query: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 727 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
Query: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 782 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 841 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
Query: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 899 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 1017
Query: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 1018 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1073
Query: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 1074 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1133
Query: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 1134 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
G F +E +G+++T S ++ A D
Sbjct: 1194 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 135 bits (339), Expect = 9e-31
Identities = 151/588 (25%), Positives = 259/588 (44%), Gaps = 77/588 (13%)
Query: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 193 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 987 DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042
D+D + + F N D FT+ T GI R + L DRE Y + A D
Sbjct: 430 DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 485
Query: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
GV PV + + V D NDN P FP ++V V + G V Q+TAVD DEG N I
Sbjct: 486 GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR----ATVHV 1157
Y+I+ G + F ++ +G +T ++ + Y + VQA +AP R TV++
Sbjct: 545 TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
Query: 1158 RLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
++ N+ SP Q++++ +S ++ + A D + D + Y+ E G+ +
Sbjct: 604 EVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAIENGDPQR 659
Query: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
+ +++T+G L L + LD +++T +DG T+ + +V+
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 707
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 143,480,773
Number of Sequences: 37866
Number of extensions: 7813732
Number of successful extensions: 55532
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 400
Number of HSP's successfully gapped in prelim test: 729
Number of HSP's that attempted gapping in prelim test: 31458
Number of HSP's gapped (non-prelim): 10392
length of query: 3312
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3191
effective length of database: 13,665,732
effective search space: 43607350812
effective search space used: 43607350812
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.