Search of human proteins with 142976733

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|142976733 surface glycoprotein, Ig superfamily member [Homo
sapiens]
         (1264 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|142976733 surface glycoprotein, Ig superfamily member [Homo s...  2584   0.0  
gi|15147240 brother of CDO [Homo sapiens]                             478   e-134
gi|75709184 contactin 3 [Homo sapiens]                                182   2e-45
gi|28373129 contactin 5 isoform short [Homo sapiens]                  179   2e-44
gi|7657359 contactin 5 isoform long [Homo sapiens]                    172   1e-42
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]            169   2e-41
gi|4827022 contactin 2 precursor [Homo sapiens]                       164   6e-40
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     162   1e-39
gi|7657361 contactin 6 [Homo sapiens]                                 162   2e-39
gi|119220552 sidekick 1 [Homo sapiens]                                162   2e-39
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      161   3e-39
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    160   7e-39
gi|224994171 roundabout 1 isoform c [Homo sapiens]                    160   7e-39
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...   160   7e-39
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ...   160   7e-39
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [...   156   1e-37
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   155   2e-37
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   155   3e-37
gi|222352127 sidekick 2 [Homo sapiens]                                151   4e-36
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]            145   2e-34
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...   144   4e-34
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ...   144   4e-34
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s...   144   4e-34
gi|118572606 hemicentin 1 [Homo sapiens]                              143   1e-33
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]            142   2e-33
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...   139   2e-32
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi...   137   5e-32
gi|109150416 peroxidasin [Homo sapiens]                               137   8e-32
gi|157311649 neogenin homolog 1 [Homo sapiens]                        134   4e-31
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap...   134   7e-31

>gi|142976733 surface glycoprotein, Ig superfamily member [Homo
            sapiens]
          Length = 1264

 Score = 2584 bits (6698), Expect = 0.0
 Identities = 1264/1264 (100%), Positives = 1264/1264 (100%)

Query: 1    MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRIS 60
            MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRIS
Sbjct: 1    MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRIS 60

Query: 61   WLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGD 120
            WLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGD
Sbjct: 61   WLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGD 120

Query: 121  FGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILN 180
            FGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILN
Sbjct: 121  FGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILN 180

Query: 181  VSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVT 240
            VSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVT
Sbjct: 181  VSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVT 240

Query: 241  LECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVK 300
            LECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVK
Sbjct: 241  LECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVK 300

Query: 301  YVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLT 360
            YVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLT
Sbjct: 301  YVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLT 360

Query: 361  AGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGD 420
            AGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGD
Sbjct: 361  AGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGD 420

Query: 421  FVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQA 480
            FVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQA
Sbjct: 421  FVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQA 480

Query: 481  GASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDR 540
            GASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDR
Sbjct: 481  GASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDR 540

Query: 541  SKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRA 600
            SKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRA
Sbjct: 541  SKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRA 600

Query: 601  GKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSA 660
            GKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSA
Sbjct: 601  GKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSA 660

Query: 661  AGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGV 720
            AGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGV
Sbjct: 661  AGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGV 720

Query: 721  PEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSV 780
            PEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSV
Sbjct: 721  PEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSV 780

Query: 781  EVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSD 840
            EVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSD
Sbjct: 781  EVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSD 840

Query: 841  TQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSY 900
            TQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSY
Sbjct: 841  TQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSY 900

Query: 901  DIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPAR 960
            DIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPAR
Sbjct: 901  DIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPAR 960

Query: 961  SSDMLYLIVGCVLGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYT 1020
            SSDMLYLIVGCVLGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYT
Sbjct: 961  SSDMLYLIVGCVLGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYT 1020

Query: 1021 TLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRT 1080
            TLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRT
Sbjct: 1021 TLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRT 1080

Query: 1081 HVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVPVVA 1140
            HVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVPVVA
Sbjct: 1081 HVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVPVVA 1140

Query: 1141 PYPQDGLEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSD 1200
            PYPQDGLEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSD
Sbjct: 1141 PYPQDGLEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSD 1200

Query: 1201 GSEDPAEFSRGDSCAHSETEINIVSWNALILPPVPEGCAEKTMWSPPGIPLDSPTEVLQQ 1260
            GSEDPAEFSRGDSCAHSETEINIVSWNALILPPVPEGCAEKTMWSPPGIPLDSPTEVLQQ
Sbjct: 1201 GSEDPAEFSRGDSCAHSETEINIVSWNALILPPVPEGCAEKTMWSPPGIPLDSPTEVLQQ 1260

Query: 1261 PRET 1264
            PRET
Sbjct: 1261 PRET 1264


>gi|15147240 brother of CDO [Homo sapiens]
          Length = 1114

 Score =  478 bits (1231), Expect = e-134
 Identities = 337/888 (37%), Positives = 448/888 (50%), Gaps = 85/888 (9%)

Query: 139 IGCRVPESNPKAEVRYKIRGKWLEHSTENY-LILPSGNLQILNVSLEDKGSYKCAAYNPV 197
           +GC V    P+  V +++ GK L  S +   +++  G L I  ++    G Y+C A  P 
Sbjct: 55  LGCVVEP--PRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPA 112

Query: 198 THQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQV-YWL 256
                V        +     D  H++         +    P          P  QV Y +
Sbjct: 113 GAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLP-------ESHPKAQVRYSV 165

Query: 257 KDGQDIAPGSNWRRLYS-HLATDSVDPADSGNYSCMAGNK-------SGDVKYVTYMVNV 308
           K     A   N+  + S +L   +    D G Y C A N        SG    +    + 
Sbjct: 166 KQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRST 225

Query: 309 LEHASISKGLQDQ--IVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNGLK 366
            E A I    + Q  IV+ G ++   C   G P P  TW  +   +    +     + L 
Sbjct: 226 AEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLL 285

Query: 367 ISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVAD-GDFVTLS 425
           I   + ED G Y+C+ADNG+G       + + N   F+P  +T  +S  V   G    L+
Sbjct: 286 IDTTSEEDSGTYRCMADNGVG--QPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLT 343

Query: 426 CNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSL 485
           C   G P P + W  +   + S         S++ +LSR                   +L
Sbjct: 344 CEVRGNPPPSVLWLRNAVPLIS---------SQRLRLSR------------------RAL 376

Query: 486 HIQAVTQEHAGKYICEAANEHGTTQAEASLMVV-PFETNTKAETVTLPDAAQNDDRSKRD 544
            + ++  E  G Y C A NE G+  A   L    P  T    +   L         SK  
Sbjct: 377 RVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLG 436

Query: 545 GSETGL-----LSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWR 599
             E  L     L   P  V P++ +   EK     +  +APIILS P+T   D+Y LVWR
Sbjct: 437 NPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPA--EAPIILSSPRTSKTDSYELVWR 494

Query: 600 AGKDGG--LPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVA 657
              +G    PI  Y VK+RK+ +       W    +P +++ L L  L+P SLYEV M A
Sbjct: 495 PRHEGSGRAPILYYVVKHRKVTNSSD---DWTISGIPANQHRLTLTRLDPGSLYEVEMAA 551

Query: 658 RSAAGEGQPAMLTFRTS---KEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDS 714
            + AGEGQ AM+TFRT    K +  +SK  Q      G       S  +++       D 
Sbjct: 552 YNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPG------ASPQSSSQ-----PDH 600

Query: 715 SRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMR-TSNWLVAAEDI 773
            R S  PEAPDRPTISTASETSVYVTWIPR NGG PI +F+VEYK+++   +W++A   I
Sbjct: 601 GRLSP-PEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAI 659

Query: 774 PPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIA 833
           PPS+LSVE+  LE G++YKFRV A+N  GES  S+ SRPY V G+  R   RP+ GP+I 
Sbjct: 660 PPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYIT 719

Query: 834 YTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGH 893
           +T+AV++T IMLKW YIP+SNNNTPI GFYIYYRPTDSDNDSDYK+D+VEG K WH I H
Sbjct: 720 FTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISH 779

Query: 894 LQPETSYDIKMQCFNEGGESEFSNVMICETKVKR---VPGASEYPVKDLSTPPNSLGSGG 950
           LQPETSYDIKMQCFNEGGESEFSNVMICETK ++    PG    P      PP       
Sbjct: 780 LQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIER 839

Query: 951 NVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWK--NRQQNT 996
            VG     ARSSD+ YLIVG VLG +VLI++ FI  CLW+  ++Q++T
Sbjct: 840 PVGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHT 887



 Score =  302 bits (773), Expect = 2e-81
 Identities = 161/399 (40%), Positives = 230/399 (57%), Gaps = 8/399 (2%)

Query: 1   MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRIS 60
           M P++   C LL    T  C +  +++ P  T +P S VQK GG V+L C  +P    ++
Sbjct: 12  MRPEVTLACLLL---ATAGCFADLNEV-PQVTVQPASTVQKPGGTVILGCVVEPPRMNVT 67

Query: 61  WLHNGKTLDGNLEH--VKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVL 118
           W  NGK L+G+ +   V I  GTL I +LN+  +G YQC+A    GA+ S PATV++A L
Sbjct: 68  WRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANL 127

Query: 119 GDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQI 178
            DF    +HVI  +E +   I C +PES+PKA+VRY ++ +WLE S  NYLI+PSGNLQI
Sbjct: 128 QDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQI 187

Query: 179 LNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSP 238
           +N S ED+G YKCAAYNPVT ++K      +L V R +++   I++P  +Q + V     
Sbjct: 188 VNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQS 247

Query: 239 VTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGD 298
           + LECV SG+P P+V W KDG  +   +  R L S+L  D+    DSG Y CMA N  G 
Sbjct: 248 LILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQ 307

Query: 299 --VKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSA 356
                + Y V V E   ++  L   ++  G +   TC+V GNP P+  W  NA P+  S 
Sbjct: 308 PGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ 367

Query: 357 RHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRL 395
           R   +   L++  +  ED G+YQC+A+N +G  H+  +L
Sbjct: 368 RLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQL 406


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score =  182 bits (461), Expect = 2e-45
 Identities = 212/971 (21%), Positives = 364/971 (37%), Gaps = 157/971 (16%)

Query: 29  PYFTSEPLSAVQKLGGP---VVLHCSAQP-VTTRISWLHNGKTLDGNLEH-VKIHQGTLT 83
           P F  EP +++  +G     + LHC A+   +    W  NG  +D ++EH  K++ G L 
Sbjct: 26  PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLV 85

Query: 84  ILSLNSSL-LGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCR 142
           +++ N +   G YQC A NS+G IVS  A +  A L +F +  +  ++  E     + C 
Sbjct: 86  VINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCG 145

Query: 143 VPESNPKAEVRYKIRG--KWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTH- 199
            P  + +    +       ++E  +  ++   +G+L I  V   D G+Y C   + VT+ 
Sbjct: 146 PPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNA 205

Query: 200 QLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLK-D 258
           ++   P    L       +    +     + L     S V LEC   G P PQ+ W + D
Sbjct: 206 RVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSD 265

Query: 259 GQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGL 318
           G   +     R+    L   +    D+G+Y C+A N  G        +         + +
Sbjct: 266 GLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGK-NVARGRLTYYAKPHWVQLI 324

Query: 319 QDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNGLKISGVTVEDVGMY 378
           +D  +++  ++++ C   G P P+  W  N   +    R       L IS ++V D GM+
Sbjct: 325 KDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMF 384

Query: 379 QCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVS--AKVADGDFVTLSCNASGLPVPVI 436
           QC+A+N  G ++S+  L++       P     P+    +V  G  V+L C     P  + 
Sbjct: 385 QCIAENKHGLVYSSAELKVVASA---PDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALS 441

Query: 437 RWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAG 496
            W      +  H                            +S      L I  VT+  AG
Sbjct: 442 SWKKGDVSVQEHER--------------------------ISLLNDGGLKIANVTKADAG 475

Query: 497 KYICEAANEHGTTQAEASLMVVPFETNTKA---------ETVTLPDAAQNDD-------- 539
            Y C A N+ G       L+V      T A         E+V LP   Q+D         
Sbjct: 476 TYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTW 535

Query: 540 -------RSKRDGS---ETGLLSSFPVKVHPSAVESAPE------------KNASGISVP 577
                    K+DGS   + G  SS  + +    ++ + +             +A+ + V 
Sbjct: 536 YFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVR 595

Query: 578 DAPIILSPPQT-----HTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVR 632
            +P    PP+       T  T  L W+ GKD   P+ +Y ++ R     VG    W TV 
Sbjct: 596 GSP---GPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQAR-TPFSVG----WQTVT 647

Query: 633 -----VPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQAS 687
                + G  +   + EL P   YE  +VA +  G G+P++ + +   E+          
Sbjct: 648 TVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEE---------- 697

Query: 688 SPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTW--IPRA 745
                +P+ P                          P        S + + +TW  +P  
Sbjct: 698 ----AVPEVP--------------------------PSEVNGGGGSRSELVITWDPVPEE 727

Query: 746 NGGSPITAFKVEYKRMRTSNWL---VAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYG 802
                   + V ++ +  + W+   V + D P  +      S+ P S Y+ +V   N+ G
Sbjct: 728 LQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTP--RYVFRNESIVPYSPYEVKVGVYNNKG 785

Query: 803 ESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGF 862
           E        P+  V         P   P      ++S ++I + W  IP   +N  + G+
Sbjct: 786 EG-------PFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGY 838

Query: 863 YIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFS---NVM 919
            + Y       +S  K  V  G++    +  L+   +Y   ++ +N  G   FS   NV 
Sbjct: 839 EVRYWNGGGKEESSSKMKVA-GNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVT 897

Query: 920 ICETKVKRVPG 930
             +T   + PG
Sbjct: 898 TKKTPPSQPPG 908



 Score =  119 bits (297), Expect = 2e-26
 Identities = 206/885 (23%), Positives = 332/885 (37%), Gaps = 126/885 (14%)

Query: 43  GGPVVLHCSAQPVTTRIS--WLHN---GKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQC 97
           G  VVL C   P +  +S  W+ N       + +   V    G L I  +  S +G Y C
Sbjct: 137 GQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTC 196

Query: 98  LANNSI-GAIVSGPATVSV----AVLGDFGSSTK----HVITAEEKSAGFIGCRVPESNP 148
           +  + +  A V G  T  V     V+G++    +      + A + S   + C     NP
Sbjct: 197 VVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLEC-FALGNP 255

Query: 149 KAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGR 208
             ++ ++ R   L  S++  L   SG L+I N   ED GSY+C A N    + K    GR
Sbjct: 256 IPQINWR-RSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENS---RGKNVARGR 311

Query: 209 KLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNW 268
               ++P     H +       +AV     +  EC  SG P P   WLK+G  +      
Sbjct: 312 LTYYAKP-----HWVQLIKDVEIAV--EDSLYWECRASGKPKPSYRWLKNGAALVLEERT 364

Query: 269 RRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSL--G 326
           +     L   ++   DSG + C+A NK G V     +  V      SK    ++V +  G
Sbjct: 365 QIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVG 424

Query: 327 ATVHFTCDVHGNPAPNCTWFHNAQPIHPSAR-HLTAGNGLKISGVTVEDVGMYQCVADNG 385
           + V   C    +P    +W      +    R  L    GLKI+ VT  D G Y C+A+N 
Sbjct: 425 SLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQ 484

Query: 386 IGFMHSTGRLEIENDGGFKPVIIT-APVSAKVADGDFVTLSCNASGLPVP--VIRWYDSH 442
            G  + T  L +      +P  IT AP +  V+ G+ V L C     P+   +  WY + 
Sbjct: 485 FGKANGTTHLVVT-----EPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNG 539

Query: 443 GLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASS--LHIQAVTQEHAGKYIC 500
            L                   + +G + E V       G+SS  L I+ +  +H+GKY+C
Sbjct: 540 ALADF----------------KKDGSHFEKV------GGSSSGDLMIRNIQLKHSGKYVC 577

Query: 501 EAANEHGTTQAEASLMVV----PFETNTKAETVTLPDAAQNDDRSKRDGSET---GLLSS 553
                  +  + A L+V     P E N K + +T   A  +    K + S      + + 
Sbjct: 578 MVQTGVDSVSSAADLIVRGSPGPPE-NVKVDEITDTTAQLSWKEGKDNHSPVISYSIQAR 636

Query: 554 FPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNL---------VWRAGKDG 604
            P  V    V + PE              +   +THT     L         V  + K G
Sbjct: 637 TPFSVGWQTVTTVPE--------------VIDGKTHTATVVELNPWVEYEFRVVASNKIG 682

Query: 605 GLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLA-ELEPSSLYEVLMVARSAAGE 663
           G   +    K R  ++ V  +         GS +EL +  +  P  L           GE
Sbjct: 683 GGEPSLPSEKVRT-EEAVPEVPPSEVNGGGGSRSELVITWDPVPEELQN---------GE 732

Query: 664 GQPAMLTFR-----TSKEKTASSKNTQA----SSPPVGIPKYPVVSEAANNN----FGVV 710
           G   ++ FR     T  +   +S +T      +   V    Y V     NN     F  V
Sbjct: 733 GFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPV 792

Query: 711 LTDSSRHSGVPEAPDRPTISTASETSVYVTW--IPRANGGSPITAFKVEYKRMRTSNWLV 768
            T  S       AP + + ++ S + + V+W  IP       +  ++V Y          
Sbjct: 793 TTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESS 852

Query: 769 AAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPIT 828
           +   +  ++ S  +R L+    Y   V A N       S+ + P+          + P  
Sbjct: 853 SKMKVAGNETSARLRGLKSNLAYYTAVRAYN-------SAGAGPFSATVNVTTKKTPPSQ 905

Query: 829 GPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDN 873
            P      A +DT+++L W  + +  N + + G+ ++YR +  +N
Sbjct: 906 PPGNVVWNA-TDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNN 949


>gi|28373129 contactin 5 isoform short [Homo sapiens]
          Length = 1026

 Score =  179 bits (453), Expect = 2e-44
 Identities = 215/985 (21%), Positives = 358/985 (36%), Gaps = 167/985 (16%)

Query: 11  LLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGP---VVLHCSAQ--PVTTRISWLHNG 65
           +L++++T +C S S D  P F  EP   +         V L+C  +  PV +   WL NG
Sbjct: 8   MLFLSVT-MCLSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPS-YRWLRNG 65

Query: 66  KTLDGNLEH-VKIHQGTLTILSLNSSL-LGYYQCLANNSIGAIVSGPATVSVAVLGDFGS 123
             +D   ++   +  GT  I + + +   G+YQCLA N++G+I+S  AT+  A LG+F  
Sbjct: 66  TEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSG 125

Query: 124 STKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRG--KWLEHSTENYLILPSGNLQILNV 181
            T+  ++  E     + C  P  +P+    +       ++   +  ++   +GNL I  V
Sbjct: 126 RTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKV 185

Query: 182 SLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSR-SPVT 240
              D GSY C   N VT+   + P     L +     +       H       ++ + V 
Sbjct: 186 QTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVK 245

Query: 241 LECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVK 300
           +EC   G P P + W+K    I   +  R+  + L   +V   D+G Y C A N  G   
Sbjct: 246 MECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNS 305

Query: 301 YVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLT 360
           +    + V  +    + L D  +  G+ + + C   G P P   W  N  P+ P +R   
Sbjct: 306 F-RGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEM 364

Query: 361 AGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAK----- 415
               L I  V   D GMYQC+A+N  G ++++  L+I         + +AP  A      
Sbjct: 365 VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI---------LASAPTFALNQLKK 415

Query: 416 ---VADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEP 472
              V     V + C   G P P I W            + +R   R + L  P+G     
Sbjct: 416 TIIVTKDQEVVIECKPQGSPKPTISW--------KKGDRAVRENKRIAIL--PDG----- 460

Query: 473 VYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMV--------------- 517
                      SL I   ++   GKY+C   N  G+ +  ASL V               
Sbjct: 461 -----------SLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTEL 509

Query: 518 -------------------VPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKV 558
                              V F    K + +   +   + +  +   S   L+    + +
Sbjct: 510 TVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLM 569

Query: 559 HPSAVESAPEKNASGISVPDAPIILSPP--------QTHTPDTYNLVWRAGKDGGLPINA 610
           H        +  A  +S     ++  PP        +  T  T  L W    D   PI++
Sbjct: 570 HAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISS 629

Query: 611 YFVKYRKLDDGVGMLGSWHTVR-----VPGSENELHLAELEPSSLYEVLMVARSAAGEGQ 665
           Y ++ R        LG W TV+     + G        +L P   YE  +VA +  G G 
Sbjct: 630 YNLQAR----SPFSLG-WQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGD 684

Query: 666 PAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPD 725
           P                    S+P          S     N  V  T          AP 
Sbjct: 685 P--------------------STP----------SRMIRTNEAVPKT----------APT 704

Query: 726 RPTISTASETSVYVTWIP------RANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLS 779
             +  +     + + W P         G   I AF+    R      + ++E    SK  
Sbjct: 705 NVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSE---ASKFI 761

Query: 780 VEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVS 839
               S+ P + ++ +V   N+ G+        P+  +         P   P      +VS
Sbjct: 762 YRDESVPPLTPFEVKVGVYNNKGDG-------PFSQIVVICSAEGEPSAAPTDVKATSVS 814

Query: 840 DTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETS 899
            ++I++ W +I  S      QGF + Y   D + +   +     G++ + ++  L+  T 
Sbjct: 815 VSEILVAWKHIKESLGRP--QGFEVGYW-KDMEQEDTAETVKTRGNESFVILTGLEGNTL 871

Query: 900 YDIKMQCFNEGGESEFSNVMICETK 924
           Y   ++ +N  G    S+ +   TK
Sbjct: 872 YHFTVRAYNGAGYGPPSSEVSATTK 896



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 52/226 (23%), Positives = 94/226 (41%), Gaps = 12/226 (5%)

Query: 719 GVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAA---EDIPP 775
           G P  P    +   +E++  ++W P A+  SPI+++ ++ +   +  W       E I  
Sbjct: 595 GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 654

Query: 776 SKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYT 835
              S     L P   Y+FRV+A N  G    S+ SR  +         + P T P     
Sbjct: 655 DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTN------EAVPKTAPTNVSG 708

Query: 836 EAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQ 895
            +    ++++ W  +     N    G+ + +RP  +    +      E SK  +    + 
Sbjct: 709 RSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVP 768

Query: 896 PETSYDIKMQCFNEGGESEFSN-VMICETKVKRVPGASEYPVKDLS 940
           P T +++K+  +N  G+  FS  V+IC  + +  P A+   VK  S
Sbjct: 769 PLTPFEVKVGVYNNKGDGPFSQIVVICSAEGE--PSAAPTDVKATS 812



 Score = 30.8 bits (68), Expect = 8.6
 Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 7/61 (11%)

Query: 630 TVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSP 689
           TV+  G+E+ + L  LE ++LY   + A + AG G P       S E +A++K +  S  
Sbjct: 851 TVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPP-------SSEVSATTKKSPPSQA 903

Query: 690 P 690
           P
Sbjct: 904 P 904


>gi|7657359 contactin 5 isoform long [Homo sapiens]
          Length = 1100

 Score =  172 bits (437), Expect = 1e-42
 Identities = 211/972 (21%), Positives = 348/972 (35%), Gaps = 166/972 (17%)

Query: 24  SSDLAPYFTSEPLSAVQKLGGP---VVLHCSAQ--PVTTRISWLHNGKTLDGNLEH-VKI 77
           S D  P F  EP   +         V L+C  +  PV +   WL NG  +D   ++   +
Sbjct: 94  SVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPS-YRWLRNGTEIDLESDYRYSL 152

Query: 78  HQGTLTILSLNSSL-LGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSA 136
             GT  I + + +   G+YQCLA N++G+I+S  AT+  A LG+F   T+  ++  E   
Sbjct: 153 IDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQG 212

Query: 137 GFIGCRVPESNPKAEVRYKIRG--KWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAY 194
             + C  P  +P+    +       ++   +  ++   +GNL I  V   D GSY C   
Sbjct: 213 VVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVK 272

Query: 195 NPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSR-SPVTLECVVSGVPAPQV 253
           N VT+   + P     L +     +       H       ++ + V +EC   G P P +
Sbjct: 273 NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 332

Query: 254 YWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHAS 313
            W+K    I   +  R+  + L   +V   D+G Y C A N  G   +    + V  +  
Sbjct: 333 TWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSF-RGQLQVYTYPH 391

Query: 314 ISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNGLKISGVTVE 373
             + L D  +  G+ + + C   G P P   W  N  P+ P +R       L I  V   
Sbjct: 392 WVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQS 451

Query: 374 DVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAK--------VADGDFVTLS 425
           D GMYQC+A+N  G ++++  L+I         + +AP  A         V     V + 
Sbjct: 452 DAGMYQCLAENKYGAIYASAELKI---------LASAPTFALNQLKKTIIVTKDQEVVIE 502

Query: 426 CNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSL 485
           C   G P P I W            + +R   R + L  P+G                SL
Sbjct: 503 CKPQGSPKPTISW--------KKGDRAVRENKRIAIL--PDG----------------SL 536

Query: 486 HIQAVTQEHAGKYICEAANEHGTTQAEASLMV---------------------------- 517
            I   ++   GKY+C   N  G+ +  ASL V                            
Sbjct: 537 RILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAI 596

Query: 518 ------VPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNA 571
                 V F    K + +   +   + +  +   S   L+    + +H        +  A
Sbjct: 597 HDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTA 656

Query: 572 SGISVPDAPIILSPP--------QTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVG 623
             +S     ++  PP        +  T  T  L W    D   PI++Y ++ R       
Sbjct: 657 DSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR----SPF 712

Query: 624 MLGSWHTVR-----VPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKT 678
            LG W TV+     + G        +L P   YE  +VA +  G G P            
Sbjct: 713 SLG-WQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDP------------ 759

Query: 679 ASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVY 738
                   S+P          S     N  V  T          AP   +  +     + 
Sbjct: 760 --------STP----------SRMIRTNEAVPKT----------APTNVSGRSGRRHELV 791

Query: 739 VTWIP------RANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYK 792
           + W P         G   I AF+    R      + ++E    SK      S+ P + ++
Sbjct: 792 IAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSE---ASKFIYRDESVPPLTPFE 848

Query: 793 FRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPS 852
            +V   N+ G+        P+  +         P   P      +VS ++I++ W +I  
Sbjct: 849 VKVGVYNNKGDG-------PFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKE 901

Query: 853 SNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGE 912
           S      QGF + Y   D + +   +     G++ + ++  L+  T Y   ++ +N  G 
Sbjct: 902 SLGRP--QGFEVGYW-KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGY 958

Query: 913 SEFSNVMICETK 924
              S+ +   TK
Sbjct: 959 GPPSSEVSATTK 970



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 52/226 (23%), Positives = 94/226 (41%), Gaps = 12/226 (5%)

Query: 719 GVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAA---EDIPP 775
           G P  P    +   +E++  ++W P A+  SPI+++ ++ +   +  W       E I  
Sbjct: 669 GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 728

Query: 776 SKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYT 835
              S     L P   Y+FRV+A N  G    S+ SR  +         + P T P     
Sbjct: 729 DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTN------EAVPKTAPTNVSG 782

Query: 836 EAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQ 895
            +    ++++ W  +     N    G+ + +RP  +    +      E SK  +    + 
Sbjct: 783 RSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVP 842

Query: 896 PETSYDIKMQCFNEGGESEFSN-VMICETKVKRVPGASEYPVKDLS 940
           P T +++K+  +N  G+  FS  V+IC  + +  P A+   VK  S
Sbjct: 843 PLTPFEVKVGVYNNKGDGPFSQIVVICSAEGE--PSAAPTDVKATS 886



 Score = 30.8 bits (68), Expect = 8.6
 Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 7/61 (11%)

Query: 630 TVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSP 689
           TV+  G+E+ + L  LE ++LY   + A + AG G P       S E +A++K +  S  
Sbjct: 925 TVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPP-------SSEVSATTKKSPPSQA 977

Query: 690 P 690
           P
Sbjct: 978 P 978


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score =  169 bits (428), Expect = 2e-41
 Identities = 227/993 (22%), Positives = 362/993 (36%), Gaps = 162/993 (16%)

Query: 11  LLYVTLTILCSSVSSDL-APYFTSEPLSAVQKLGGP---VVLHCSAQP-VTTRISWLHNG 65
           LL +   ILC +  S L  P F  EP   +  L      V L+C  +      I W  NG
Sbjct: 7   LLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNG 66

Query: 66  KTLDGNLE-HVKIHQGTLTILSLNSSL-LGYYQCLANNSIGAIVSGPATVSVAVLGDFGS 123
             +D  ++    + +G+L I + N +   G YQC A NS G IVS  A +  A L +F +
Sbjct: 67  TDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKT 126

Query: 124 STKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSL 183
            T+  ++        + C  P  + +    +             ++   +GNL I  V  
Sbjct: 127 RTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEK 186

Query: 184 EDKGSYKCAAYNPVTHQLKVEPIGRKLL----VSRPSSDDVHILHPTHSQALAVLSRSPV 239
            D G+Y C   N VT+   + P    +L    V       + +  P   + +     + V
Sbjct: 187 SDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFP---ETVPTAKGATV 243

Query: 240 TLECVVSGVPAPQVYWLK-DGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGD 298
            LEC   G P P + W + DG+ IA  +   +    L   +    D+G Y C+A N  G 
Sbjct: 244 KLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGK 303

Query: 299 VKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARH 358
                 +    +   I K + D  V++   V + C  +G P P   W  N +P+    R 
Sbjct: 304 NVARGQLTFYAQPNWIQK-INDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRI 362

Query: 359 LTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDG-GFKPVIITAPVSAKVA 417
                 L I+ V + D GMYQC+A+N  G + S   L +   G  F   ++      KV 
Sbjct: 363 QIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKV- 421

Query: 418 DGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVL 477
            G  V + C     P PV  W             +L+   R                  +
Sbjct: 422 -GGEVVIECKPKASPKPVYTWKKGR--------DILKENER----------------ITI 456

Query: 478 SQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASL--------MVVPFETN-TKAET 528
           S+ G  +L I  VT+  AG Y C A N  GT  +  +L        MV P   + T  E+
Sbjct: 457 SEDG--NLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGES 514

Query: 529 VTLP----------------------DAAQNDDRSKRDGSETG----LLSSFPVKVHPSA 562
           + LP                      D  ++ D  +R G +      ++ +  +K H   
Sbjct: 515 IVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK-HAGK 573

Query: 563 VESAPEKNASGISVPDAPIILSPP--------QTHTPDTYNLVWRAGKDGGLPINAYFVK 614
                + +   +S     I+  PP           T  T  L WR G D   PI  Y ++
Sbjct: 574 YVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQ 633

Query: 615 YRKLDDGVGMLGSWHTVR-----VPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAML 669
            R     VG    W  V      + G      +  L P   YE   VA +  G G+P+  
Sbjct: 634 AR-TPFSVG----WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPS-- 686

Query: 670 TFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTI 729
                  + +  + T+ + P V                                P   + 
Sbjct: 687 -------RPSEKRRTEEALPEV-------------------------------TPANVSG 708

Query: 730 STASETSVYVTW------IPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVR 783
              S++ + +TW      +    G   + AF+  Y +M     ++A+ D   S+      
Sbjct: 709 GGGSKSELVITWETVPEELQNGRGFGYVVAFR-PYGKMIWMLTVLASAD--ASRYVFRNE 765

Query: 784 SLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQI 843
           S+ P S ++ +V   N+ GE   S  +  Y            P   P   +  ++S T I
Sbjct: 766 SVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA-------EEEPTKPPASIFARSLSATDI 818

Query: 844 MLKWTYIPSSNNNTPIQGFYI-YYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDI 902
            + W   P   N   IQG+ + Y+R  D + ++   R V  G++    I +L+    Y +
Sbjct: 819 EVFWA-SPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV--GNQTSTKITNLKGSVLYHL 875

Query: 903 KMQCFNEGGESEFSNVMICETKVKRVPGASEYP 935
            ++ +N  G    S  +   T   R P  S+ P
Sbjct: 876 AVKAYNSAGTGPSSATVNVTT---RKPPPSQPP 905



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 54/233 (23%), Positives = 91/233 (39%), Gaps = 24/233 (10%)

Query: 719 GVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAA---EDIPP 775
           G P  P+  TI   ++T+  ++W P  +  SPIT + ++ +   +  W   +   E I  
Sbjct: 595 GPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDG 654

Query: 776 SKLSVEVRSLEPGSTYKFRVIAIN--HYGESFRSSASRPYQVVGFPNRFSSRPITGPHIA 833
              +  V  L P   Y+FR +A N    GE  R S  R  +         + P   P   
Sbjct: 655 KTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTE--------EALPEVTPANV 706

Query: 834 YTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGH 893
                S +++++ W  +P    N    G+ + +RP              + S+       
Sbjct: 707 SGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNES 766

Query: 894 LQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSL 946
           + P + +++K+  FN  GE  FS   +       V  A E P K    PP S+
Sbjct: 767 VHPFSPFEVKVGVFNNKGEGPFSPTTV-------VYSAEEEPTK----PPASI 808


>gi|4827022 contactin 2 precursor [Homo sapiens]
          Length = 1040

 Score =  164 bits (414), Expect = 6e-40
 Identities = 221/1006 (21%), Positives = 368/1006 (36%), Gaps = 186/1006 (18%)

Query: 11  LLYVTLTILCSSVSSD-------LAPYFTSEPLSAV---QKLGGPVVLHCSAQ---PVTT 57
           LL   + ++ SS  S          P F  +PLS +   +     V+L C A+   P T 
Sbjct: 12  LLVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATY 71

Query: 58  RISWLHNGKTLDGNLEHVKIHQ---GTLTILSLNSSL-LGYYQCLANNSIGAIVSGPATV 113
           R  W  NG  +   LE    HQ   G L I++   +   G YQCLA+N +G +VS  A +
Sbjct: 72  R--WKMNGTEM--KLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAIL 127

Query: 114 SVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRG--KWLEHSTENYLIL 171
               L +F    +  + A E     + C  P   P    R+ +     ++     +++  
Sbjct: 128 RFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQ 187

Query: 172 PSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPT----- 226
            +GNL I   +  D G+Y C A + +    K   +  K      +++D  +  P+     
Sbjct: 188 TTGNLYIARTNASDLGNYSCLATSHMDFSTK--SVFSKFAQLNLAAEDTRLFAPSIKARF 245

Query: 227 HSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSG 286
            ++  A++ +  VTLEC   G P P++ W K    ++P   W      L   SV   D G
Sbjct: 246 PAETYALVGQQ-VTLECFAFGNPVPRIKWRKVDGSLSP--QWTTAEPTLQIPSVSFEDEG 302

Query: 287 NYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWF 346
            Y C A N  G    V   + V       K + D    +G+ + + C   G P P   W 
Sbjct: 303 TYECEAENSKGR-DTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWL 361

Query: 347 HNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIE---NDGGF 403
            N +P+    R       L+ S +++ED GMYQCVA+N  G ++++  L ++    D   
Sbjct: 362 RNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRL 421

Query: 404 KPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLS 463
            PV    P     A G  + + C     P  V+ W        S  +++L + SR +   
Sbjct: 422 NPVRRLIP----AARGGEILIPCQPRAAPKAVVLW--------SKGTEILVNSSRVT--V 467

Query: 464 RPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETN 523
            P+G                +L I+ +++   GKY C A N  G   +   L V      
Sbjct: 468 TPDG----------------TLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKI 511

Query: 524 TKA---------ETVTLPDAAQNDDRSKRDGSETGLLSSFPVK----------------- 557
           T A         + +TL   A +D     D + T  L  FP+                  
Sbjct: 512 TLAPSSADINLGDNLTLQCHASHD--PTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETI 569

Query: 558 ------------------VHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWR 599
                             +  + V+SA ++    +  P  P      +     T  L W 
Sbjct: 570 GDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWS 629

Query: 600 AGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVR-----VPGSENELHLAELEPSSLYEVL 654
            G D   PI  Y ++ R         G W  VR     + G+     +  L P   YE  
Sbjct: 630 RGFDNHSPIAKYTLQAR-----TPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFR 684

Query: 655 MVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDS 714
           ++A +  G G+P+           +S   T+ ++P V                       
Sbjct: 685 VIASNILGTGEPS---------GPSSKIRTREAAPSVA---------------------P 714

Query: 715 SRHSGVPEAPDRPTISTASETSVYVTWIPRA----NGGSPITAFKVEYKRMRTSNWLVAA 770
           S  SG   AP            + V W P +    NG      + + ++R  +++W  A 
Sbjct: 715 SGLSGGGGAPG----------ELIVNWTPMSREYQNGDG--FGYLLSFRRQGSTHWQTAR 762

Query: 771 EDIPPSKLSVEV---RSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPI 827
             +P +     V    S+ P + ++ ++ + N  G+   S  +  Y            P 
Sbjct: 763 --VPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSA-------EEEPR 813

Query: 828 TGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQ 887
             P   + + VS +++ + W  +    N   +     Y++  D +  +D  R    G   
Sbjct: 814 VAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVR--TAGLDT 871

Query: 888 WHMIGHLQPETSYDIKMQCFNEGG---ESEFSNVMICETKVKRVPG 930
              +  L P T Y + ++ +N  G    S  +N    +   +R PG
Sbjct: 872 SARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPG 917


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  162 bits (411), Expect = 1e-39
 Identities = 221/932 (23%), Positives = 350/932 (37%), Gaps = 160/932 (17%)

Query: 16  LTILCSSV---SSDLAPYFTSEPLSAVQKLGGPVVLHCSAQP-VTTRISWLHNGKTLDGN 71
           L  LCS       D  P     P   +   G P  L+C A+   T  I W   G+ ++ +
Sbjct: 13  LICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD 72

Query: 72  LEHVKIHQ-----GTLTILSLNSSLL-----GYYQCLANNSIGAIVSGPATVSVAVL-GD 120
            +  + H+     G+L  L +          G Y C+A N +G  VS  A++ VA+L  D
Sbjct: 73  KDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD 132

Query: 121 FGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILN 180
           F  +   V+ A  + A  + C+ P  +P+  + +K  G  L+   E  + +  G L I  
Sbjct: 133 FRQNPSDVMVAVGEPA-VMECQPPRGHPEPTISWKKDGSPLDDKDER-ITIRGGKLMITY 190

Query: 181 VSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVT 240
               D G Y C   N V    +   +    ++ RPS     +  P++   LAV       
Sbjct: 191 TRKSDAGKYVCVGTNMVGE--RESEVAELTVLERPS----FVKRPSN---LAVTVDDSAE 241

Query: 241 LECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSH-LATDSVDPADSGNYSCMAGNKSGDV 299
            +C   G P P V W KD  ++ P S +     H L    V   D G+Y+C+A N  G  
Sbjct: 242 FKCEARGDPVPTVRWRKDDGEL-PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300

Query: 300 KYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTW--------FHNAQP 351
           +  +  + V E        +DQ+V+LG TV F C+  GNP P   W          + QP
Sbjct: 301 E-ASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 359

Query: 352 IHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFK--PVII 408
              S+R   +  G L I+ V   DVG Y C   N  G + +   LE+ +    +  PVI 
Sbjct: 360 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 419

Query: 409 TAPVSAKVA-DGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEG 467
             PV+  VA DG FV LSC A+G PVP I W     L+++  S++               
Sbjct: 420 QGPVNQTVAVDGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRI--------------- 463

Query: 468 LNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAE 527
                      Q     L I+       G+Y C A+   G     A + V          
Sbjct: 464 ----------KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV---------- 503

Query: 528 TVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQ 587
                              E G+    P    P+ + SAP K       P+   +     
Sbjct: 504 ------------------QEFGVPVQPPRPTDPNLIPSAPSK-------PEVTDV----- 533

Query: 588 THTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEP 647
             + +T  L W+   + G    +Y ++      G     SW TV          +  L+P
Sbjct: 534 --SRNTVTLSWQPNLNSGATPTSYIIEAFSHASG----SSWQTVAENVKTETSAIKGLKP 587

Query: 648 SSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNF 707
           +++Y  L+ A +A G   P+ ++     +    +          G+    V  E  N   
Sbjct: 588 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQ--------GVDHKQVQRELGNAVL 639

Query: 708 GVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYK----RMRT 763
            +                 PT+ ++S   V+ T   ++     I  +K+ Y+        
Sbjct: 640 HL---------------HNPTVLSSSSIEVHWTVDQQS---QYIQGYKILYRPSGANHGE 681

Query: 764 SNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFS 823
           S+WLV  E   P+K SV +  L  G  Y+   I    +   F+ + S     + F     
Sbjct: 682 SDWLV-FEVRTPAKNSVVIPDLRKGVNYE---IKARPFFNEFQGADSE----IKFAKTLE 733

Query: 824 SRPITGPHIAYTEAVSD---TQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYK-R 879
             P + P    T + +D   T I++ W   P    N  +Q + ++       N++ Y   
Sbjct: 734 EAP-SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC----LGNETRYHIN 788

Query: 880 DVVEGSKQWHMIGHLQPETSYDIKMQCFNEGG 911
             V+GS    +I  L P   Y +++      G
Sbjct: 789 KTVDGSTFSVVIPFLVPGIRYSVEVAASTGAG 820



 Score =  152 bits (383), Expect = 3e-36
 Identities = 199/847 (23%), Positives = 329/847 (38%), Gaps = 168/847 (19%)

Query: 139 IGCRVPESNPKAEVRYKIRGKWLEHSTEN----YLILPSGNLQILNV-----SLEDKGSY 189
           + C+  E  P   + +   G+ +E   ++     ++LPSG+L  L +     S  D+G Y
Sbjct: 48  LNCKA-EGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 106

Query: 190 KCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQA---LAVLSRSPVTLECVVS 246
            C A N +              VS  +S +V IL     Q    + V    P  +EC   
Sbjct: 107 VCVARNYLGEA-----------VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 155

Query: 247 -GVPAPQVYWLKDGQDIAPGSNWRRLYS-HLATDSVDPADSGNYSCMAGNKSGDVKYVTY 304
            G P P + W KDG  +        +    L       +D+G Y C+  N  G+ +    
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215

Query: 305 MVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNG 364
            + VLE  S  K   +  V++  +  F C+  G+P P   W  +   +  S   +   + 
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHT 275

Query: 365 LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTL 424
           LKI  VT  D+G Y CVA+N +G   ++  L ++      P  +  P    VA G  VT 
Sbjct: 276 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP----PHFVVKPRDQVVALGRTVTF 331

Query: 425 SCNASGLPVPVIRWY--DSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGA 482
            C A+G P P I W    S  L+ S+  Q  +S SR                F +SQ G 
Sbjct: 332 QCEATGNPQPAIFWRREGSQNLLFSY--QPPQSSSR----------------FSVSQTG- 372

Query: 483 SSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSK 542
             L I  V +   G YIC+  N  G+   +A L V                         
Sbjct: 373 -DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV------------------------- 406

Query: 543 RDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGK 602
                T +++  P    P  +   P      +   D   +LS   T +P    ++WR  K
Sbjct: 407 -----TDVIADRP----PPVIRQGPVNQTVAV---DGTFVLSCVATGSP-VPTILWR--K 451

Query: 603 DGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAG 662
           DG L ++    + ++L++GV                ++  A+L  +  Y    +A + +G
Sbjct: 452 DGVL-VSTQDSRIKQLENGV---------------LQIRYAKLGDTGRYTC--IASTPSG 493

Query: 663 EGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPE 722
           E                ++ +        G+P  P      N               +P 
Sbjct: 494 E----------------ATWSAYIEVQEFGVPVQPPRPTDPNL--------------IPS 523

Query: 723 APDRPTISTASETSVYVTWIPRANGGSPITAFKVE-YKRMRTSNWLVAAEDIPPSKLSVE 781
           AP +P ++  S  +V ++W P  N G+  T++ +E +     S+W   AE++     +  
Sbjct: 524 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSA 581

Query: 782 VRSLEPGSTYKFRVIAINHYGESFRSSASRPYQV-------VGFPNRFSSRPITGP--HI 832
           ++ L+P + Y F V A N YG S  S  S P +         G  ++   R +     H+
Sbjct: 582 IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHL 641

Query: 833 AYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDN-DSDY-KRDVVEGSKQWHM 890
                +S + I + WT    S     IQG+ I YRP+ +++ +SD+   +V   +K   +
Sbjct: 642 HNPTVLSSSSIEVHWTVDQQSQY---IQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV 698

Query: 891 IGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGG 950
           I  L+   +Y+IK + F       F+     ++++K      E P    S PP  +    
Sbjct: 699 IPDLRKGVNYEIKARPF-------FNEFQGADSEIKFAKTLEEAP----SAPPQGVTVSK 747

Query: 951 NVGPATS 957
           N G  T+
Sbjct: 748 NDGNGTA 754



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 19/123 (15%)

Query: 385 GIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGL 444
           G+  + S  RL  E+   F P I+  P    V+ G+  TL+C A G P P I WY     
Sbjct: 12  GLICLCSGSRLRQED---FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGER 68

Query: 445 ITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAAN 504
           + +      +   R  ++  P G     ++F+    G  S       +   G Y+C A N
Sbjct: 69  VETD-----KDDPRSHRMLLPSG----SLFFLRIVHGRKS-------RPDEGVYVCVARN 112

Query: 505 EHG 507
             G
Sbjct: 113 YLG 115


>gi|7657361 contactin 6 [Homo sapiens]
          Length = 1028

 Score =  162 bits (410), Expect = 2e-39
 Identities = 217/979 (22%), Positives = 356/979 (36%), Gaps = 152/979 (15%)

Query: 12  LYVTLTILCSSVSSDLA--PYFTSEPLSAVQKLG---GPVVLHCSAQPVTT-RISWLHNG 65
           L + L ++ SS    L   P FT EP   +  L      V+L+C+A    +    W  NG
Sbjct: 7   LVILLPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNG 66

Query: 66  KTLDGNLE-HVKIHQGTLTILSLNSSL-LGYYQCLANNSIGAIVSGPATVSVAVLGDFGS 123
             +D  +  H ++  G+L I S ++   +G YQCLA N +G I+S  A +  A + DF +
Sbjct: 67  TDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFET 126

Query: 124 STKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGK--WLEHSTENYLILPSGNLQILNV 181
            T+  ++  E     + C  P         +       +++     ++   +GNL I  V
Sbjct: 127 KTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKV 186

Query: 182 SLEDKGSYKCAAYNPVTHQLKVEP----IGRKLLVSRPSSDDVHILHPTHSQALAVLSRS 237
              D G+Y C   N    +    P    + R   V       + +  P   QA      S
Sbjct: 187 EPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAA---KDS 243

Query: 238 PVTLECVVSGVPAPQVYWLK-DGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKS 296
            V LEC   G P P + W + DG  +     + +  + L   +    D G Y C+A N  
Sbjct: 244 SVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLR 303

Query: 297 GDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSA 356
           G       ++         K +Q+  +S+   + + C   G P P  TW  N + ++P  
Sbjct: 304 GRNLAKGQLIFYAPPEWEQK-IQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEE 362

Query: 357 RHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAK- 415
           R       L I+ + V D G+YQC A+N    +++   L +       P    +PV  K 
Sbjct: 363 RIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASA---PDFSKSPVKKKS 419

Query: 416 -VADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVY 474
            V  G  + + C  +  P   I W           ++ LR   R                
Sbjct: 420 FVQVGGDIVIGCKPNAFPRAAISW--------KRGTETLRQSKR---------------I 456

Query: 475 FVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMV-------VPFETN--TK 525
           F+L      SL I  +T+  AG Y C A N+ GT +   SL+V       VP      T 
Sbjct: 457 FLLED---GSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTV 513

Query: 526 AETVTLPDAAQNDDR-----------------------SKRDGSETGLLSSFPVKVHPSA 562
            E++ LP    +D                          +  G   G L    +++H S 
Sbjct: 514 GESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSG 573

Query: 563 -VESAPEKNASGISVPDAPIILSPP--------QTHTPDTYNLVWRAGKDGGLPINAYFV 613
                 +     +S     I+  PP        +  +  T  L WRAG D   PI  + +
Sbjct: 574 KYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTI 633

Query: 614 KYRKLDDGVGMLGSWHTV-RVP----GSENELHLAELEPSSLYEVLMVARSAAGEGQPAM 668
           + R     VG    W  V  VP    G      +  L P   YE  +VA ++ G G+P+ 
Sbjct: 634 QTR-TPFSVG----WQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPS- 687

Query: 669 LTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPT 728
                   + +    T+AS P                    V+   + H G         
Sbjct: 688 --------EPSELLRTKASVP--------------------VVAPVNIHGG--------- 710

Query: 729 ISTASETSVYVTW--IPRANGGSPITAFKVEYKRMRTSNW-LVAAEDIPPSKLSVEVRSL 785
               S + + +TW  IP          + + ++ + ++ W       +  S+      S+
Sbjct: 711 --GGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESI 768

Query: 786 EPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIML 845
            P S ++ +V   N+ GE   S+ +  Y            P   P     ++ S +++ +
Sbjct: 769 IPLSPFEVKVGVYNNEGEGSLSTVTIVYS-------GEDEPQLAPRGTSLQSFSASEMEV 821

Query: 846 KWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQ 905
            W  I  + N   + G+ + Y  TD   +S   +  V G+     I  L+  T Y   ++
Sbjct: 822 SWNAIAWNRNTGRVLGYEVLYW-TDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVR 880

Query: 906 CFNEGGESEFSNVMICETK 924
            +N  G    S  +   TK
Sbjct: 881 AYNTAGTGPSSPPVNVTTK 899


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score =  162 bits (409), Expect = 2e-39
 Identities = 233/984 (23%), Positives = 361/984 (36%), Gaps = 158/984 (16%)

Query: 11  LLYVTLTILCSSVSSDLAPYFTSEP-LSAVQKLGGPVVLHCSAQPV-TTRISWLHNGKTL 68
           LL + L +L +    D+APYF +EP L  +   G  +VL C A+        W+ +   L
Sbjct: 86  LLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSEL 145

Query: 69  DGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHV 128
                  K       I SL     G+Y+C+  N +GA++   + V VA +G F   T   
Sbjct: 146 TTYSSEYKY-----IIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSF-MDTDQR 199

Query: 129 ITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGS 188
            T  +  A  +      S P+ +V +   G  +  S    + L +  L IL  +  D G+
Sbjct: 200 KTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLEN-QLVILATTTSDAGA 258

Query: 189 YKCAAYNPVTHQLKVEPIGRKLL---VSRPSSDDVHILHPTHSQALAVLSRSPVTLECVV 245
           Y   A N    + K  P     +   V  P +    I+ P  ++++ V   S  TLEC+ 
Sbjct: 259 YYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSV-VAGSSETTLECIA 317

Query: 246 SGVPAPQ--VYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAG--NKSGDVKY 301
           S  P     V W ++G  I  G +       L   +   AD+G Y C A     + +   
Sbjct: 318 SARPVEDLSVTWKRNGVRITSGLH--SFGRRLTISNPTSADTGPYVCEAALPGSAFEPAR 375

Query: 302 VTYMVNVLEHASISKGLQDQI-VSLGATVHFTCDVHGNPAPNCTWFHNAQPI----HPSA 356
            T  + ++E    +   + +I   +  TV   C   G P P   W+ +A  I    +P  
Sbjct: 376 ATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRY 435

Query: 357 RHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKV 416
           + L +G GL+I  +  ED G++QC A N  G + +   L++ N     PV    PV   V
Sbjct: 436 KVLASG-GLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTN---IAPVFTQRPVDTTV 491

Query: 417 ADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFV 476
            DG    L C  SG P P I W   + ++ S   ++ R                    F+
Sbjct: 492 TDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPR--------------------FM 531

Query: 477 LSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASL-------MVVPFETNT--KAE 527
           L ++G   L I  V  + AG Y C AAN  G+  A A+L       +V P E +   K  
Sbjct: 532 LLESG--GLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGT 589

Query: 528 TVTLPDAAQNDDR-----------------------SKRDGS------ETGLLSSFPVKV 558
           T TL   A +D R                        ++DGS       +G +  +  ++
Sbjct: 590 TATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEI 649

Query: 559 HPSAVESAPEKNASGISVPDAP--IILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYR 616
                  +       I +P +P  +++SP  +H+     L W    DG  PI  Y V+  
Sbjct: 650 VSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHS-HAVVLSWVRPFDGNSPILYYIVELS 708

Query: 617 KLDDGVGMLGSW--HTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTS 674
           + +        W  H   V      + ++ L P+  Y+  + A +  G GQ +  T    
Sbjct: 709 ENN------SPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAET---- 758

Query: 675 KEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASE 734
                 S+      PP   PK  V S   N                              
Sbjct: 759 ------SRLMLPEEPPSAPPKNIVASGRTNQ----------------------------- 783

Query: 735 TSVYVTW--IPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYK 792
            S+ V W   P       +  + + Y+               P      V  L   + Y+
Sbjct: 784 -SIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYE 842

Query: 793 FRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPS 852
            +V A N  G    S A   Y + G P          P    TEAV+ T I   W   P 
Sbjct: 843 IQVAAYNGAGLGVFSRAVTEYTLQGVPT-------APPQNVQTEAVNSTTIQFLWNPPPQ 895

Query: 853 SNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGH-----LQPETSYDIKMQCF 907
              N   QG+ +   P D+         VV  +  +H + H     L+  T+Y   + CF
Sbjct: 896 QFINGINQGYKLLAWPADAPE----AVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCF 951

Query: 908 NEGGESEFSNVMICETKVKRVPGA 931
              G+   S   +  T+  + PGA
Sbjct: 952 TTPGDGPPSTPQLVWTQEDK-PGA 974



 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 58/213 (27%), Positives = 91/213 (42%), Gaps = 14/213 (6%)

Query: 723  APDRPTISTASETSVYVTWIP----RANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKL 778
            AP   T+ TASETS+ + W+P    + NG      ++++Y R    +  VA       + 
Sbjct: 1176 APTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLER 1235

Query: 779  SVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAV 838
               +  LE    Y+ ++ A N  G         P+  V       S P   P     EAV
Sbjct: 1236 EFTIEELEEWMEYELQMQAFNAVGAG-------PWSEVVRGRTRESVPSAAPENVSAEAV 1288

Query: 839  SDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGS-KQWHMIGHLQPE 897
            S TQI+L WT +P  + N  I G+ I +R  D D +   +  +V G+  Q  ++  L+  
Sbjct: 1289 SSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEP--RSHIVRGNHTQSALLAGLRKF 1346

Query: 898  TSYDIKMQCFNEGGESEFSNVMICETKVKRVPG 930
              Y++++  F   G    S  +I E      PG
Sbjct: 1347 VLYELQVLAFTRIGNGVPSTPLILERTKDDAPG 1379



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 76/379 (20%), Positives = 136/379 (35%), Gaps = 84/379 (22%)

Query: 573  GISVPDAPIILSPPQTHTPD-------------TYNLVWRAGKDGGLPINAYFVKYRKLD 619
            G  VP  P+IL   +   P              +  +VW+  ++    I  Y + YR   
Sbjct: 1360 GNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLAS 1419

Query: 620  DGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTA 679
                   ++ TV V  +  +    +L P S Y   + A++  G G+P   T  T++++  
Sbjct: 1420 SSPH---TFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKR-- 1474

Query: 680  SSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYV 739
                 +  +PP                         R   VP+A         +  S+ +
Sbjct: 1475 -----ERPAPP-------------------------RELLVPQAE-------VTARSLRL 1497

Query: 740  TWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAIN 799
             W+P ++G SPI  F ++ + +    W   +  I     +  V  L P ++YK R+ A N
Sbjct: 1498 QWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATN 1557

Query: 800  HYGES-FRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTP 858
              G+S F S       +   P          PH       + + ++++W      + N  
Sbjct: 1558 DIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH-------TTSSVLIQWQPPRDESLNGL 1610

Query: 859  IQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHM---------------------IGHLQPE 897
            +QG+ IYYR  + +  S  +   ++     H                      + HL+  
Sbjct: 1611 LQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKY 1670

Query: 898  TSYDIKMQCFNEGGESEFS 916
              Y++ M  +N  GES  S
Sbjct: 1671 RRYEVIMTAYNIIGESPAS 1689



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 64/233 (27%), Positives = 106/233 (45%), Gaps = 18/233 (7%)

Query: 710  VLTDSSRHSGVPE----APDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSN 765
            ++T S+  SGVP     AP    IS  S  S  + + P  +G + I+ + VE +     +
Sbjct: 1055 LVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGD 1114

Query: 766  ---WLVA-AEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNR 821
               W+    E+  P    +E+ +L P + Y+FR+  +N  G S  S +SR  Q +  P  
Sbjct: 1115 EEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAP-- 1172

Query: 822  FSSRPITGPHIAYTEAVSDTQIMLKWTYIPSS--NNNTPIQGFYIYYRPTDSDNDSDYKR 879
                P   P        S+T + L+W  +P S  N N    G+ I Y  +D  + S   +
Sbjct: 1173 ----PDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQS-SAVAQ 1227

Query: 880  DVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGAS 932
             V +  ++   I  L+    Y+++MQ FN  G   +S V+   T+ + VP A+
Sbjct: 1228 VVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTR-ESVPSAA 1279



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 55/258 (21%), Positives = 99/258 (38%), Gaps = 26/258 (10%)

Query: 692  GIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPI 751
            G+P  P++ E   ++              P  P R        TSV + W P       I
Sbjct: 1362 GVPSTPLILERTKDD-------------APGPPVRLVFPEVRLTSVRIVWQPPEEPNGII 1408

Query: 752  TAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASR 811
              +++ Y+   +S       ++  +        L P S Y FR+ A        R     
Sbjct: 1409 LGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSA------KTRQGWGE 1462

Query: 812  PYQVVGFPNRFSSRPITGPHIAYTEA-VSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTD 870
            P +          RP     +   +A V+   + L+W  +P S+  +PI+ F +  R   
Sbjct: 1463 PLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQW--VPGSDGASPIRYFTMQVRELP 1520

Query: 871  SDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPG 930
                  Y   +   +    ++  L+P TSY ++++  N+ G+S+FS+     T ++ VPG
Sbjct: 1521 RGEWQTYSSSISHEATAC-VVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPG 1579

Query: 931  ASEYPVKDLSTPPNSLGS 948
                P   +S  P++  S
Sbjct: 1580 E---PPGSVSATPHTTSS 1594



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 32/101 (31%), Positives = 50/101 (49%), Gaps = 5/101 (4%)

Query: 719  GVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKL 778
            G P +P R  + T S + + + W    +G +P T + +E +      W +  +DIP S  
Sbjct: 1901 GSPGSP-RDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSAT 1959

Query: 779  S--VEVRSLEPGSTYKFRVIAINH--YGESFRSSASRPYQV 815
            S  + +  L  G TY+FRV+A+N   YGE    S +   QV
Sbjct: 1960 SYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQV 2000



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 78/359 (21%), Positives = 130/359 (36%), Gaps = 40/359 (11%)

Query: 582  ILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVR--VPGSENE 639
            +L P    T  +  L W  G DG  PI  + ++ R+L  G      W T    +      
Sbjct: 1483 LLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRG-----EWQTYSSSISHEATA 1537

Query: 640  LHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVV 699
              +  L P + Y++ + A +  G+                 S  T+A +    +P  P  
Sbjct: 1538 CVVDRLRPFTSYKLRLKATNDIGDSD--------------FSSETEAVTTLQDVPGEPPG 1583

Query: 700  SEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIP-RANGGSPITAFK--V 756
            S +A  +     T SS         D           +Y   +   A  G+     K  +
Sbjct: 1584 SVSATPH-----TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPI 1638

Query: 757  EYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQV- 815
                  T+       +   +    E+  L+    Y+  + A N  GES    AS P +V 
Sbjct: 1639 ALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGES---PASAPVEVF 1695

Query: 816  VGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDS 875
            VG      + P   P       ++ +Q+ + W   P  + N  IQG+ IYY   DS N++
Sbjct: 1696 VG-----EAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNET 1750

Query: 876  DYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEY 934
            + K  V+   +    + +L   T Y + +  FN  G+   S+     T  +  PGA  +
Sbjct: 1751 E-KMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTH-QAAPGAPSF 1807



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 49/206 (23%), Positives = 91/206 (44%), Gaps = 17/206 (8%)

Query: 717  HSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRM---RTSNWLVAAEDI 773
            H   P AP     S  + T++ V+W   A     +  ++V Y+ +   +  + +V  E  
Sbjct: 1798 HQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVR 1857

Query: 774  PPSKLSVEVRSLEPGSTYKFRVIAIN-HYGESFRSSASRPYQVVGFPNRFSSRPITGPHI 832
               +  ++VR L  G TY FRV A    YG   +++      +   P   S  P +   +
Sbjct: 1858 GNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQAN------ITAGPAEGS--PGSPRDV 1909

Query: 833  AYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHM-I 891
              T++ S  ++ L+WT     + +TP  G+ I  RP+D      + +D+   +  + + +
Sbjct: 1910 LVTKSAS--ELTLQWT--EGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSL 1965

Query: 892  GHLQPETSYDIKMQCFNEGGESEFSN 917
              L+   +Y+ ++   NE G  E SN
Sbjct: 1966 DKLRQGVTYEFRVVAVNEAGYGEPSN 1991



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 5/82 (6%)

Query: 588  THTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENE--LHLAEL 645
            T +     L W  G  G  P   Y ++ R  D+G   L       +P S     L L +L
Sbjct: 1912 TKSASELTLQWTEGHSGDTPTTGYVIEARPSDEG---LWDMFVKDIPRSATSYTLSLDKL 1968

Query: 646  EPSSLYEVLMVARSAAGEGQPA 667
                 YE  +VA + AG G+P+
Sbjct: 1969 RQGVTYEFRVVAVNEAGYGEPS 1990



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 52/245 (21%), Positives = 89/245 (36%), Gaps = 36/245 (14%)

Query: 710  VLTDSSRHSGVPEAPDRPTISTASETSVYVTW--IPRANGGSPITAFKVEYKRMRTSNWL 767
            V+   +R S    AP+  +    S T + +TW  +P  +    I  +K+          L
Sbjct: 1266 VVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKI----------L 1315

Query: 768  VAAEDIPPSKLSVEVRSLEPGST----------YKFRVIAINHYGESFRSSASRPYQVVG 817
              A+D+ P   S  VR     S           Y+ +V+A    G    S+   P  +  
Sbjct: 1316 FRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPST---PLILER 1372

Query: 818  FPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDY 877
              +     P+    + + E V  T + + W   P    N  I G+ I YR   S   +  
Sbjct: 1373 TKDDAPGPPV---RLVFPE-VRLTSVRIVWQ--PPEEPNGIILGYQIAYRLASSSPHTFT 1426

Query: 878  KRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVK 937
              +V    +Q+     L PE++Y  ++      G  E     +  T+ +  P     P +
Sbjct: 1427 TVEVGATVRQF-TATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPA----PPR 1481

Query: 938  DLSTP 942
            +L  P
Sbjct: 1482 ELLVP 1486


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  161 bits (408), Expect = 3e-39
 Identities = 217/919 (23%), Positives = 346/919 (37%), Gaps = 157/919 (17%)

Query: 26  DLAPYFTSEPLSAVQKLGGPVVLHCSAQP-VTTRISWLHNGKTLDGNLEHVKIHQ----- 79
           D  P     P   +   G P  L+C A+   T  I W   G+ ++ + +  + H+     
Sbjct: 65  DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124

Query: 80  GTLTILSLNSSLL-----GYYQCLANNSIGAIVSGPATVSVAVL-GDFGSSTKHVITAEE 133
           G+L  L +          G Y C+A N +G  VS  A++ VA+L  DF  +   V+ A  
Sbjct: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184

Query: 134 KSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAA 193
           + A  + C+ P  +P+  + +K  G  L+   E  + +  G L I      D G Y C  
Sbjct: 185 EPA-VMECQPPRGHPEPTISWKKDGSPLDDKDER-ITIRGGKLMITYTRKSDAGKYVCVG 242

Query: 194 YNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQV 253
            N V    +   +    ++ RPS     +  P++   LAV        +C   G P P V
Sbjct: 243 TNMVGE--RESEVAELTVLERPS----FVKRPSN---LAVTVDDSAEFKCEARGDPVPTV 293

Query: 254 YWLKDGQDIAPGSNWRRLYSH-LATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHA 312
            W KD  ++ P S +     H L    V   D G+Y+C+A N  G  +  +  + V E  
Sbjct: 294 RWRKDDGEL-PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAE-ASATLTVQEPP 351

Query: 313 SISKGLQDQIVSLGATVHFTCDVHGNPAPNCTW--------FHNAQPIHPSARHLTAGNG 364
                 +DQ+V+LG TV F C+  GNP P   W          + QP   S+R   +  G
Sbjct: 352 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411

Query: 365 -LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFK--PVIITAPVSAKVA-DGD 420
            L I+ V   DVG Y C   N  G + +   LE+ +    +  PVI   PV+  VA DG 
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 471

Query: 421 FVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQA 480
           FV LSC A+G PVP I W     L+++  S++                          Q 
Sbjct: 472 FV-LSCVATGSPVPTILWRKDGVLVSTQDSRI-------------------------KQL 505

Query: 481 GASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDR 540
               L I+       G+Y C A+   G     A + V                       
Sbjct: 506 ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV----------------------- 542

Query: 541 SKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRA 600
                 E G+    P    P+ + SAP K       P+   +       + +T  L W+ 
Sbjct: 543 -----QEFGVPVQPPRPTDPNLIPSAPSK-------PEVTDV-------SRNTVTLSWQP 583

Query: 601 GKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSA 660
             + G    +Y ++      G     SW TV          +  L+P+++Y  L+ A +A
Sbjct: 584 NLNSGATPTSYIIEAFSHASG----SSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 639

Query: 661 AGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGV 720
            G   P+ ++     +    +          G+    V  E  N    +           
Sbjct: 640 YGISDPSQISDPVKTQDVLPTSQ--------GVDHKQVQRELGNAVLHL----------- 680

Query: 721 PEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYK----RMRTSNWLVAAEDIPPS 776
                 PT+ ++S   V+ T   ++     I  +K+ Y+        S+WLV  E   P+
Sbjct: 681 ----HNPTVLSSSSIEVHWTVDQQS---QYIQGYKILYRPSGANHGESDWLV-FEVRTPA 732

Query: 777 KLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTE 836
           K SV +  L  G  Y+   I    +   F+ + S     + F       P + P    T 
Sbjct: 733 KNSVVIPDLRKGVNYE---IKARPFFNEFQGADSE----IKFAKTLEEAP-SAPPQGVTV 784

Query: 837 AVSD---TQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYK-RDVVEGSKQWHMIG 892
           + +D   T I++ W   P    N  +Q + ++       N++ Y     V+GS    +I 
Sbjct: 785 SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC----LGNETRYHINKTVDGSTFSVVIP 840

Query: 893 HLQPETSYDIKMQCFNEGG 911
            L P   Y +++      G
Sbjct: 841 FLVPGIRYSVEVAASTGAG 859



 Score =  152 bits (383), Expect = 3e-36
 Identities = 199/847 (23%), Positives = 329/847 (38%), Gaps = 168/847 (19%)

Query: 139 IGCRVPESNPKAEVRYKIRGKWLEHSTEN----YLILPSGNLQILNV-----SLEDKGSY 189
           + C+  E  P   + +   G+ +E   ++     ++LPSG+L  L +     S  D+G Y
Sbjct: 87  LNCKA-EGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 145

Query: 190 KCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQA---LAVLSRSPVTLECVVS 246
            C A N +              VS  +S +V IL     Q    + V    P  +EC   
Sbjct: 146 VCVARNYLGEA-----------VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 194

Query: 247 -GVPAPQVYWLKDGQDIAPGSNWRRLYS-HLATDSVDPADSGNYSCMAGNKSGDVKYVTY 304
            G P P + W KDG  +        +    L       +D+G Y C+  N  G+ +    
Sbjct: 195 RGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 254

Query: 305 MVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNG 364
            + VLE  S  K   +  V++  +  F C+  G+P P   W  +   +  S   +   + 
Sbjct: 255 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHT 314

Query: 365 LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTL 424
           LKI  VT  D+G Y CVA+N +G   ++  L ++      P  +  P    VA G  VT 
Sbjct: 315 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP----PHFVVKPRDQVVALGRTVTF 370

Query: 425 SCNASGLPVPVIRWY--DSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGA 482
            C A+G P P I W    S  L+ S+  Q  +S SR                F +SQ G 
Sbjct: 371 QCEATGNPQPAIFWRREGSQNLLFSY--QPPQSSSR----------------FSVSQTG- 411

Query: 483 SSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSK 542
             L I  V +   G YIC+  N  G+   +A L V                         
Sbjct: 412 -DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV------------------------- 445

Query: 543 RDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGK 602
                T +++  P    P  +   P      +   D   +LS   T +P    ++WR  K
Sbjct: 446 -----TDVIADRP----PPVIRQGPVNQTVAV---DGTFVLSCVATGSP-VPTILWR--K 490

Query: 603 DGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAG 662
           DG L ++    + ++L++GV                ++  A+L  +  Y    +A + +G
Sbjct: 491 DGVL-VSTQDSRIKQLENGV---------------LQIRYAKLGDTGRYTC--IASTPSG 532

Query: 663 EGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPE 722
           E                ++ +        G+P  P      N               +P 
Sbjct: 533 E----------------ATWSAYIEVQEFGVPVQPPRPTDPNL--------------IPS 562

Query: 723 APDRPTISTASETSVYVTWIPRANGGSPITAFKVE-YKRMRTSNWLVAAEDIPPSKLSVE 781
           AP +P ++  S  +V ++W P  N G+  T++ +E +     S+W   AE++     +  
Sbjct: 563 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSA 620

Query: 782 VRSLEPGSTYKFRVIAINHYGESFRSSASRPYQV-------VGFPNRFSSRPITGP--HI 832
           ++ L+P + Y F V A N YG S  S  S P +         G  ++   R +     H+
Sbjct: 621 IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHL 680

Query: 833 AYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDN-DSDY-KRDVVEGSKQWHM 890
                +S + I + WT    S     IQG+ I YRP+ +++ +SD+   +V   +K   +
Sbjct: 681 HNPTVLSSSSIEVHWTVDQQSQY---IQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV 737

Query: 891 IGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGG 950
           I  L+   +Y+IK + F       F+     ++++K      E P    S PP  +    
Sbjct: 738 IPDLRKGVNYEIKARPF-------FNEFQGADSEIKFAKTLEEAP----SAPPQGVTVSK 786

Query: 951 NVGPATS 957
           N G  T+
Sbjct: 787 NDGNGTA 793



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 34/125 (27%), Positives = 50/125 (40%), Gaps = 21/125 (16%)

Query: 383 DNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSH 442
           DN +G+  S  R E      F P I+  P    V+ G+  TL+C A G P P I WY   
Sbjct: 51  DNSLGYTGSRLRQE-----DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGG 105

Query: 443 GLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEA 502
             + +      +   R  ++  P G     ++F+    G  S       +   G Y+C A
Sbjct: 106 ERVETD-----KDDPRSHRMLLPSG----SLFFLRIVHGRKS-------RPDEGVYVCVA 149

Query: 503 ANEHG 507
            N  G
Sbjct: 150 RNYLG 154


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  160 bits (405), Expect = 7e-39
 Identities = 223/934 (23%), Positives = 350/934 (37%), Gaps = 161/934 (17%)

Query: 16  LTILCSSV---SSDLAPYFTSEPLSAVQKLGGPVVLHCSAQP-VTTRISWLHNGKTLDGN 71
           L  LCS       D  P     P   +   G P  L+C A+   T  I W   G+ ++ +
Sbjct: 13  LICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD 72

Query: 72  LEHVKIHQ-----GTLTILSLNSSLL-----GYYQCLANNSIGAIVSGPATVSVAVL-GD 120
            +  + H+     G+L  L +          G Y C+A N +G  VS  A++ VA+L  D
Sbjct: 73  KDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD 132

Query: 121 FGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILN 180
           F  +   V+ A  + A  + C+ P  +P+  + +K  G  L+   E  + +  G L I  
Sbjct: 133 FRQNPSDVMVAVGEPA-VMECQPPRGHPEPTISWKKDGSPLDDKDER-ITIRGGKLMITY 190

Query: 181 VSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVT 240
               D G Y C   N V    +   +    ++ RPS     +  P++   LAV       
Sbjct: 191 TRKSDAGKYVCVGTNMVGE--RESEVAELTVLERPS----FVKRPSN---LAVTVDDSAE 241

Query: 241 LECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSH-LATDSVDPADSGNYSCMAGNKSGDV 299
            +C   G P P V W KD  ++ P S +     H L    V   D G+Y+C+A N  G  
Sbjct: 242 FKCEARGDPVPTVRWRKDDGEL-PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300

Query: 300 K-YVTYMVNV-LEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTW--------FHNA 349
           +   T  V V  E        +DQ+V+LG TV F C+  GNP P   W          + 
Sbjct: 301 EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360

Query: 350 QPIHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFK--PV 406
           QP   S+R   +  G L I+ V   DVG Y C   N  G + +   LE+ +    +  PV
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 407 IITAPVSAKVA-DGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRP 465
           I   PV+  VA DG FV LSC A+G PVP I W     L+++  S++             
Sbjct: 421 IRQGPVNQTVAVDGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRI------------- 466

Query: 466 EGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTK 525
                        Q     L I+       G+Y C A+   G     A + V        
Sbjct: 467 ------------KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV-------- 506

Query: 526 AETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSP 585
                                E G+    P    P+ + SAP K       P+   +   
Sbjct: 507 --------------------QEFGVPVQPPRPTDPNLIPSAPSK-------PEVTDV--- 536

Query: 586 PQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAEL 645
               + +T  L W+   + G    +Y ++      G     SW TV          +  L
Sbjct: 537 ----SRNTVTLSWQPNLNSGATPTSYIIEAFSHASG----SSWQTVAENVKTETSAIKGL 588

Query: 646 EPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANN 705
           +P+++Y  L+ A +A G   P+ ++     +    +          G+    V  E  N 
Sbjct: 589 KPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQ--------GVDHKQVQRELGNA 640

Query: 706 NFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYK----RM 761
              +                 PT+ ++S   V+ T   ++     I  +K+ Y+      
Sbjct: 641 VLHL---------------HNPTVLSSSSIEVHWTVDQQS---QYIQGYKILYRPSGANH 682

Query: 762 RTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNR 821
             S+WLV  E   P+K SV +  L  G  Y+   I    +   F+ + S     + F   
Sbjct: 683 GESDWLV-FEVRTPAKNSVVIPDLRKGVNYE---IKARPFFNEFQGADSE----IKFAKT 734

Query: 822 FSSRPITGPHIAYTEAVSD---TQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYK 878
               P + P    T + +D   T I++ W   P    N  +Q + ++       N++ Y 
Sbjct: 735 LEEAP-SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC----LGNETRYH 789

Query: 879 -RDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGG 911
               V+GS    +I  L P   Y +++      G
Sbjct: 790 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAG 823



 Score =  153 bits (386), Expect = 1e-36
 Identities = 200/847 (23%), Positives = 330/847 (38%), Gaps = 165/847 (19%)

Query: 139 IGCRVPESNPKAEVRYKIRGKWLEHSTEN----YLILPSGNLQILNV-----SLEDKGSY 189
           + C+  E  P   + +   G+ +E   ++     ++LPSG+L  L +     S  D+G Y
Sbjct: 48  LNCKA-EGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 106

Query: 190 KCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQA---LAVLSRSPVTLECVVS 246
            C A N +              VS  +S +V IL     Q    + V    P  +EC   
Sbjct: 107 VCVARNYLGEA-----------VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 155

Query: 247 -GVPAPQVYWLKDGQDIAPGSNWRRLYS-HLATDSVDPADSGNYSCMAGNKSGDVKYVTY 304
            G P P + W KDG  +        +    L       +D+G Y C+  N  G+ +    
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215

Query: 305 MVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNG 364
            + VLE  S  K   +  V++  +  F C+  G+P P   W  +   +  S   +   + 
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHT 275

Query: 365 LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTL 424
           LKI  VT  D+G Y CVA+N +G   ++  L ++  G   P  +  P    VA G  VT 
Sbjct: 276 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-GSEPPHFVVKPRDQVVALGRTVTF 334

Query: 425 SCNASGLPVPVIRWY--DSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGA 482
            C A+G P P I W    S  L+ S+  Q  +S SR                F +SQ G 
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSY--QPPQSSSR----------------FSVSQTG- 375

Query: 483 SSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSK 542
             L I  V +   G YIC+  N  G+   +A L V                         
Sbjct: 376 -DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV------------------------- 409

Query: 543 RDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGK 602
                T +++  P    P  +   P      +   D   +LS   T +P    ++WR  K
Sbjct: 410 -----TDVIADRP----PPVIRQGPVNQTVAV---DGTFVLSCVATGSP-VPTILWR--K 454

Query: 603 DGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAG 662
           DG L ++    + ++L++GV                ++  A+L  +  Y    +A + +G
Sbjct: 455 DGVL-VSTQDSRIKQLENGV---------------LQIRYAKLGDTGRYTC--IASTPSG 496

Query: 663 EGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPE 722
           E                ++ +        G+P  P      N               +P 
Sbjct: 497 E----------------ATWSAYIEVQEFGVPVQPPRPTDPNL--------------IPS 526

Query: 723 APDRPTISTASETSVYVTWIPRANGGSPITAFKVE-YKRMRTSNWLVAAEDIPPSKLSVE 781
           AP +P ++  S  +V ++W P  N G+  T++ +E +     S+W   AE++     +  
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSA 584

Query: 782 VRSLEPGSTYKFRVIAINHYGESFRSSASRPYQV-------VGFPNRFSSRPITGP--HI 832
           ++ L+P + Y F V A N YG S  S  S P +         G  ++   R +     H+
Sbjct: 585 IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHL 644

Query: 833 AYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDN-DSDY-KRDVVEGSKQWHM 890
                +S + I + WT    S     IQG+ I YRP+ +++ +SD+   +V   +K   +
Sbjct: 645 HNPTVLSSSSIEVHWTVDQQSQY---IQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV 701

Query: 891 IGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGG 950
           I  L+   +Y+IK + F       F+     ++++K      E P    S PP  +    
Sbjct: 702 IPDLRKGVNYEIKARPF-------FNEFQGADSEIKFAKTLEEAP----SAPPQGVTVSK 750

Query: 951 NVGPATS 957
           N G  T+
Sbjct: 751 NDGNGTA 757



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 19/123 (15%)

Query: 385 GIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGL 444
           G+  + S  RL  E+   F P I+  P    V+ G+  TL+C A G P P I WY     
Sbjct: 12  GLICLCSGSRLRQED---FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGER 68

Query: 445 ITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAAN 504
           + +      +   R  ++  P G     ++F+    G  S       +   G Y+C A N
Sbjct: 69  VETD-----KDDPRSHRMLLPSG----SLFFLRIVHGRKS-------RPDEGVYVCVARN 112

Query: 505 EHG 507
             G
Sbjct: 113 YLG 115


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score =  160 bits (405), Expect = 7e-39
 Identities = 223/934 (23%), Positives = 350/934 (37%), Gaps = 161/934 (17%)

Query: 16  LTILCSSV---SSDLAPYFTSEPLSAVQKLGGPVVLHCSAQP-VTTRISWLHNGKTLDGN 71
           L  LCS       D  P     P   +   G P  L+C A+   T  I W   G+ ++ +
Sbjct: 13  LICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD 72

Query: 72  LEHVKIHQ-----GTLTILSLNSSLL-----GYYQCLANNSIGAIVSGPATVSVAVL-GD 120
            +  + H+     G+L  L +          G Y C+A N +G  VS  A++ VA+L  D
Sbjct: 73  KDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD 132

Query: 121 FGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILN 180
           F  +   V+ A  + A  + C+ P  +P+  + +K  G  L+   E  + +  G L I  
Sbjct: 133 FRQNPSDVMVAVGEPA-VMECQPPRGHPEPTISWKKDGSPLDDKDER-ITIRGGKLMITY 190

Query: 181 VSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVT 240
               D G Y C   N V    +   +    ++ RPS     +  P++   LAV       
Sbjct: 191 TRKSDAGKYVCVGTNMVGE--RESEVAELTVLERPS----FVKRPSN---LAVTVDDSAE 241

Query: 241 LECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSH-LATDSVDPADSGNYSCMAGNKSGDV 299
            +C   G P P V W KD  ++ P S +     H L    V   D G+Y+C+A N  G  
Sbjct: 242 FKCEARGDPVPTVRWRKDDGEL-PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300

Query: 300 K-YVTYMVNV-LEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTW--------FHNA 349
           +   T  V V  E        +DQ+V+LG TV F C+  GNP P   W          + 
Sbjct: 301 EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360

Query: 350 QPIHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFK--PV 406
           QP   S+R   +  G L I+ V   DVG Y C   N  G + +   LE+ +    +  PV
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 407 IITAPVSAKVA-DGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRP 465
           I   PV+  VA DG FV LSC A+G PVP I W     L+++  S++             
Sbjct: 421 IRQGPVNQTVAVDGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRI------------- 466

Query: 466 EGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTK 525
                        Q     L I+       G+Y C A+   G     A + V        
Sbjct: 467 ------------KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV-------- 506

Query: 526 AETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSP 585
                                E G+    P    P+ + SAP K       P+   +   
Sbjct: 507 --------------------QEFGVPVQPPRPTDPNLIPSAPSK-------PEVTDV--- 536

Query: 586 PQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAEL 645
               + +T  L W+   + G    +Y ++      G     SW TV          +  L
Sbjct: 537 ----SRNTVTLSWQPNLNSGATPTSYIIEAFSHASG----SSWQTVAENVKTETSAIKGL 588

Query: 646 EPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANN 705
           +P+++Y  L+ A +A G   P+ ++     +    +          G+    V  E  N 
Sbjct: 589 KPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQ--------GVDHKQVQRELGNA 640

Query: 706 NFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYK----RM 761
              +                 PT+ ++S   V+ T   ++     I  +K+ Y+      
Sbjct: 641 VLHL---------------HNPTVLSSSSIEVHWTVDQQS---QYIQGYKILYRPSGANH 682

Query: 762 RTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNR 821
             S+WLV  E   P+K SV +  L  G  Y+   I    +   F+ + S     + F   
Sbjct: 683 GESDWLV-FEVRTPAKNSVVIPDLRKGVNYE---IKARPFFNEFQGADSE----IKFAKT 734

Query: 822 FSSRPITGPHIAYTEAVSD---TQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYK 878
               P + P    T + +D   T I++ W   P    N  +Q + ++       N++ Y 
Sbjct: 735 LEEAP-SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC----LGNETRYH 789

Query: 879 -RDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGG 911
               V+GS    +I  L P   Y +++      G
Sbjct: 790 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAG 823



 Score =  153 bits (386), Expect = 1e-36
 Identities = 200/847 (23%), Positives = 330/847 (38%), Gaps = 165/847 (19%)

Query: 139 IGCRVPESNPKAEVRYKIRGKWLEHSTEN----YLILPSGNLQILNV-----SLEDKGSY 189
           + C+  E  P   + +   G+ +E   ++     ++LPSG+L  L +     S  D+G Y
Sbjct: 48  LNCKA-EGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 106

Query: 190 KCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQA---LAVLSRSPVTLECVVS 246
            C A N +              VS  +S +V IL     Q    + V    P  +EC   
Sbjct: 107 VCVARNYLGEA-----------VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 155

Query: 247 -GVPAPQVYWLKDGQDIAPGSNWRRLYS-HLATDSVDPADSGNYSCMAGNKSGDVKYVTY 304
            G P P + W KDG  +        +    L       +D+G Y C+  N  G+ +    
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215

Query: 305 MVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNG 364
            + VLE  S  K   +  V++  +  F C+  G+P P   W  +   +  S   +   + 
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHT 275

Query: 365 LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTL 424
           LKI  VT  D+G Y CVA+N +G   ++  L ++  G   P  +  P    VA G  VT 
Sbjct: 276 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-GSEPPHFVVKPRDQVVALGRTVTF 334

Query: 425 SCNASGLPVPVIRWY--DSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGA 482
            C A+G P P I W    S  L+ S+  Q  +S SR                F +SQ G 
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSY--QPPQSSSR----------------FSVSQTG- 375

Query: 483 SSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSK 542
             L I  V +   G YIC+  N  G+   +A L V                         
Sbjct: 376 -DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV------------------------- 409

Query: 543 RDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGK 602
                T +++  P    P  +   P      +   D   +LS   T +P    ++WR  K
Sbjct: 410 -----TDVIADRP----PPVIRQGPVNQTVAV---DGTFVLSCVATGSP-VPTILWR--K 454

Query: 603 DGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAG 662
           DG L ++    + ++L++GV                ++  A+L  +  Y    +A + +G
Sbjct: 455 DGVL-VSTQDSRIKQLENGV---------------LQIRYAKLGDTGRYTC--IASTPSG 496

Query: 663 EGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPE 722
           E                ++ +        G+P  P      N               +P 
Sbjct: 497 E----------------ATWSAYIEVQEFGVPVQPPRPTDPNL--------------IPS 526

Query: 723 APDRPTISTASETSVYVTWIPRANGGSPITAFKVE-YKRMRTSNWLVAAEDIPPSKLSVE 781
           AP +P ++  S  +V ++W P  N G+  T++ +E +     S+W   AE++     +  
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSA 584

Query: 782 VRSLEPGSTYKFRVIAINHYGESFRSSASRPYQV-------VGFPNRFSSRPITGP--HI 832
           ++ L+P + Y F V A N YG S  S  S P +         G  ++   R +     H+
Sbjct: 585 IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHL 644

Query: 833 AYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDN-DSDY-KRDVVEGSKQWHM 890
                +S + I + WT    S     IQG+ I YRP+ +++ +SD+   +V   +K   +
Sbjct: 645 HNPTVLSSSSIEVHWTVDQQSQY---IQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV 701

Query: 891 IGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGG 950
           I  L+   +Y+IK + F       F+     ++++K      E P    S PP  +    
Sbjct: 702 IPDLRKGVNYEIKARPF-------FNEFQGADSEIKFAKTLEEAP----SAPPQGVTVSK 750

Query: 951 NVGPATS 957
           N G  T+
Sbjct: 751 NDGNGTA 757



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 19/123 (15%)

Query: 385 GIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGL 444
           G+  + S  RL  E+   F P I+  P    V+ G+  TL+C A G P P I WY     
Sbjct: 12  GLICLCSGSRLRQED---FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGER 68

Query: 445 ITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAAN 504
           + +      +   R  ++  P G     ++F+    G  S       +   G Y+C A N
Sbjct: 69  VETD-----KDDPRSHRMLLPSG----SLFFLRIVHGRKS-------RPDEGVYVCVARN 112

Query: 505 EHG 507
             G
Sbjct: 113 YLG 115


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score =  160 bits (405), Expect = 7e-39
 Identities = 223/934 (23%), Positives = 350/934 (37%), Gaps = 161/934 (17%)

Query: 16  LTILCSSV---SSDLAPYFTSEPLSAVQKLGGPVVLHCSAQP-VTTRISWLHNGKTLDGN 71
           L  LCS       D  P     P   +   G P  L+C A+   T  I W   G+ ++ +
Sbjct: 13  LICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD 72

Query: 72  LEHVKIHQ-----GTLTILSLNSSLL-----GYYQCLANNSIGAIVSGPATVSVAVL-GD 120
            +  + H+     G+L  L +          G Y C+A N +G  VS  A++ VA+L  D
Sbjct: 73  KDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD 132

Query: 121 FGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILN 180
           F  +   V+ A  + A  + C+ P  +P+  + +K  G  L+   E  + +  G L I  
Sbjct: 133 FRQNPSDVMVAVGEPA-VMECQPPRGHPEPTISWKKDGSPLDDKDER-ITIRGGKLMITY 190

Query: 181 VSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVT 240
               D G Y C   N V    +   +    ++ RPS     +  P++   LAV       
Sbjct: 191 TRKSDAGKYVCVGTNMVGE--RESEVAELTVLERPS----FVKRPSN---LAVTVDDSAE 241

Query: 241 LECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSH-LATDSVDPADSGNYSCMAGNKSGDV 299
            +C   G P P V W KD  ++ P S +     H L    V   D G+Y+C+A N  G  
Sbjct: 242 FKCEARGDPVPTVRWRKDDGEL-PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300

Query: 300 K-YVTYMVNV-LEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTW--------FHNA 349
           +   T  V V  E        +DQ+V+LG TV F C+  GNP P   W          + 
Sbjct: 301 EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360

Query: 350 QPIHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFK--PV 406
           QP   S+R   +  G L I+ V   DVG Y C   N  G + +   LE+ +    +  PV
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 407 IITAPVSAKVA-DGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRP 465
           I   PV+  VA DG FV LSC A+G PVP I W     L+++  S++             
Sbjct: 421 IRQGPVNQTVAVDGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRI------------- 466

Query: 466 EGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTK 525
                        Q     L I+       G+Y C A+   G     A + V        
Sbjct: 467 ------------KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV-------- 506

Query: 526 AETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSP 585
                                E G+    P    P+ + SAP K       P+   +   
Sbjct: 507 --------------------QEFGVPVQPPRPTDPNLIPSAPSK-------PEVTDV--- 536

Query: 586 PQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAEL 645
               + +T  L W+   + G    +Y ++      G     SW TV          +  L
Sbjct: 537 ----SRNTVTLSWQPNLNSGATPTSYIIEAFSHASG----SSWQTVAENVKTETSAIKGL 588

Query: 646 EPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANN 705
           +P+++Y  L+ A +A G   P+ ++     +    +          G+    V  E  N 
Sbjct: 589 KPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQ--------GVDHKQVQRELGNA 640

Query: 706 NFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYK----RM 761
              +                 PT+ ++S   V+ T   ++     I  +K+ Y+      
Sbjct: 641 VLHL---------------HNPTVLSSSSIEVHWTVDQQS---QYIQGYKILYRPSGANH 682

Query: 762 RTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNR 821
             S+WLV  E   P+K SV +  L  G  Y+   I    +   F+ + S     + F   
Sbjct: 683 GESDWLV-FEVRTPAKNSVVIPDLRKGVNYE---IKARPFFNEFQGADSE----IKFAKT 734

Query: 822 FSSRPITGPHIAYTEAVSD---TQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYK 878
               P + P    T + +D   T I++ W   P    N  +Q + ++       N++ Y 
Sbjct: 735 LEEAP-SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC----LGNETRYH 789

Query: 879 -RDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGG 911
               V+GS    +I  L P   Y +++      G
Sbjct: 790 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAG 823



 Score =  153 bits (386), Expect = 1e-36
 Identities = 200/847 (23%), Positives = 330/847 (38%), Gaps = 165/847 (19%)

Query: 139 IGCRVPESNPKAEVRYKIRGKWLEHSTEN----YLILPSGNLQILNV-----SLEDKGSY 189
           + C+  E  P   + +   G+ +E   ++     ++LPSG+L  L +     S  D+G Y
Sbjct: 48  LNCKA-EGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 106

Query: 190 KCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQA---LAVLSRSPVTLECVVS 246
            C A N +              VS  +S +V IL     Q    + V    P  +EC   
Sbjct: 107 VCVARNYLGEA-----------VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 155

Query: 247 -GVPAPQVYWLKDGQDIAPGSNWRRLYS-HLATDSVDPADSGNYSCMAGNKSGDVKYVTY 304
            G P P + W KDG  +        +    L       +D+G Y C+  N  G+ +    
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215

Query: 305 MVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNG 364
            + VLE  S  K   +  V++  +  F C+  G+P P   W  +   +  S   +   + 
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHT 275

Query: 365 LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTL 424
           LKI  VT  D+G Y CVA+N +G   ++  L ++  G   P  +  P    VA G  VT 
Sbjct: 276 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-GSEPPHFVVKPRDQVVALGRTVTF 334

Query: 425 SCNASGLPVPVIRWY--DSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGA 482
            C A+G P P I W    S  L+ S+  Q  +S SR                F +SQ G 
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSY--QPPQSSSR----------------FSVSQTG- 375

Query: 483 SSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSK 542
             L I  V +   G YIC+  N  G+   +A L V                         
Sbjct: 376 -DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV------------------------- 409

Query: 543 RDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGK 602
                T +++  P    P  +   P      +   D   +LS   T +P    ++WR  K
Sbjct: 410 -----TDVIADRP----PPVIRQGPVNQTVAV---DGTFVLSCVATGSP-VPTILWR--K 454

Query: 603 DGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAG 662
           DG L ++    + ++L++GV                ++  A+L  +  Y    +A + +G
Sbjct: 455 DGVL-VSTQDSRIKQLENGV---------------LQIRYAKLGDTGRYTC--IASTPSG 496

Query: 663 EGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPE 722
           E                ++ +        G+P  P      N               +P 
Sbjct: 497 E----------------ATWSAYIEVQEFGVPVQPPRPTDPNL--------------IPS 526

Query: 723 APDRPTISTASETSVYVTWIPRANGGSPITAFKVE-YKRMRTSNWLVAAEDIPPSKLSVE 781
           AP +P ++  S  +V ++W P  N G+  T++ +E +     S+W   AE++     +  
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSA 584

Query: 782 VRSLEPGSTYKFRVIAINHYGESFRSSASRPYQV-------VGFPNRFSSRPITGP--HI 832
           ++ L+P + Y F V A N YG S  S  S P +         G  ++   R +     H+
Sbjct: 585 IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHL 644

Query: 833 AYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDN-DSDY-KRDVVEGSKQWHM 890
                +S + I + WT    S     IQG+ I YRP+ +++ +SD+   +V   +K   +
Sbjct: 645 HNPTVLSSSSIEVHWTVDQQSQY---IQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV 701

Query: 891 IGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGG 950
           I  L+   +Y+IK + F       F+     ++++K      E P    S PP  +    
Sbjct: 702 IPDLRKGVNYEIKARPF-------FNEFQGADSEIKFAKTLEEAP----SAPPQGVTVSK 750

Query: 951 NVGPATS 957
           N G  T+
Sbjct: 751 NDGNGTA 757



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 19/123 (15%)

Query: 385 GIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGL 444
           G+  + S  RL  E+   F P I+  P    V+ G+  TL+C A G P P I WY     
Sbjct: 12  GLICLCSGSRLRQED---FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGER 68

Query: 445 ITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAAN 504
           + +      +   R  ++  P G     ++F+    G  S       +   G Y+C A N
Sbjct: 69  VETD-----KDDPRSHRMLLPSG----SLFFLRIVHGRKS-------RPDEGVYVCVARN 112

Query: 505 EHG 507
             G
Sbjct: 113 YLG 115


>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
           sapiens]
          Length = 1615

 Score =  160 bits (405), Expect = 7e-39
 Identities = 223/934 (23%), Positives = 350/934 (37%), Gaps = 161/934 (17%)

Query: 16  LTILCSSV---SSDLAPYFTSEPLSAVQKLGGPVVLHCSAQP-VTTRISWLHNGKTLDGN 71
           L  LCS       D  P     P   +   G P  L+C A+   T  I W   G+ ++ +
Sbjct: 13  LICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD 72

Query: 72  LEHVKIHQ-----GTLTILSLNSSLL-----GYYQCLANNSIGAIVSGPATVSVAVL-GD 120
            +  + H+     G+L  L +          G Y C+A N +G  VS  A++ VA+L  D
Sbjct: 73  KDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD 132

Query: 121 FGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILN 180
           F  +   V+ A  + A  + C+ P  +P+  + +K  G  L+   E  + +  G L I  
Sbjct: 133 FRQNPSDVMVAVGEPA-VMECQPPRGHPEPTISWKKDGSPLDDKDER-ITIRGGKLMITY 190

Query: 181 VSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVT 240
               D G Y C   N V    +   +    ++ RPS     +  P++   LAV       
Sbjct: 191 TRKSDAGKYVCVGTNMVGE--RESEVAELTVLERPS----FVKRPSN---LAVTVDDSAE 241

Query: 241 LECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSH-LATDSVDPADSGNYSCMAGNKSGDV 299
            +C   G P P V W KD  ++ P S +     H L    V   D G+Y+C+A N  G  
Sbjct: 242 FKCEARGDPVPTVRWRKDDGEL-PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300

Query: 300 K-YVTYMVNV-LEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTW--------FHNA 349
           +   T  V V  E        +DQ+V+LG TV F C+  GNP P   W          + 
Sbjct: 301 EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360

Query: 350 QPIHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFK--PV 406
           QP   S+R   +  G L I+ V   DVG Y C   N  G + +   LE+ +    +  PV
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 407 IITAPVSAKVA-DGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRP 465
           I   PV+  VA DG FV LSC A+G PVP I W     L+++  S++             
Sbjct: 421 IRQGPVNQTVAVDGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRI------------- 466

Query: 466 EGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTK 525
                        Q     L I+       G+Y C A+   G     A + V        
Sbjct: 467 ------------KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV-------- 506

Query: 526 AETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSP 585
                                E G+    P    P+ + SAP K       P+   +   
Sbjct: 507 --------------------QEFGVPVQPPRPTDPNLIPSAPSK-------PEVTDV--- 536

Query: 586 PQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAEL 645
               + +T  L W+   + G    +Y ++      G     SW TV          +  L
Sbjct: 537 ----SRNTVTLSWQPNLNSGATPTSYIIEAFSHASG----SSWQTVAENVKTETSAIKGL 588

Query: 646 EPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANN 705
           +P+++Y  L+ A +A G   P+ ++     +    +          G+    V  E  N 
Sbjct: 589 KPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQ--------GVDHKQVQRELGNA 640

Query: 706 NFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYK----RM 761
              +                 PT+ ++S   V+ T   ++     I  +K+ Y+      
Sbjct: 641 VLHL---------------HNPTVLSSSSIEVHWTVDQQS---QYIQGYKILYRPSGANH 682

Query: 762 RTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNR 821
             S+WLV  E   P+K SV +  L  G  Y+   I    +   F+ + S     + F   
Sbjct: 683 GESDWLV-FEVRTPAKNSVVIPDLRKGVNYE---IKARPFFNEFQGADSE----IKFAKT 734

Query: 822 FSSRPITGPHIAYTEAVSD---TQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYK 878
               P + P    T + +D   T I++ W   P    N  +Q + ++       N++ Y 
Sbjct: 735 LEEAP-SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC----LGNETRYH 789

Query: 879 -RDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGG 911
               V+GS    +I  L P   Y +++      G
Sbjct: 790 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAG 823



 Score =  153 bits (386), Expect = 1e-36
 Identities = 200/847 (23%), Positives = 330/847 (38%), Gaps = 165/847 (19%)

Query: 139 IGCRVPESNPKAEVRYKIRGKWLEHSTEN----YLILPSGNLQILNV-----SLEDKGSY 189
           + C+  E  P   + +   G+ +E   ++     ++LPSG+L  L +     S  D+G Y
Sbjct: 48  LNCKA-EGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 106

Query: 190 KCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQA---LAVLSRSPVTLECVVS 246
            C A N +              VS  +S +V IL     Q    + V    P  +EC   
Sbjct: 107 VCVARNYLGEA-----------VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 155

Query: 247 -GVPAPQVYWLKDGQDIAPGSNWRRLYS-HLATDSVDPADSGNYSCMAGNKSGDVKYVTY 304
            G P P + W KDG  +        +    L       +D+G Y C+  N  G+ +    
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215

Query: 305 MVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNG 364
            + VLE  S  K   +  V++  +  F C+  G+P P   W  +   +  S   +   + 
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHT 275

Query: 365 LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTL 424
           LKI  VT  D+G Y CVA+N +G   ++  L ++  G   P  +  P    VA G  VT 
Sbjct: 276 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-GSEPPHFVVKPRDQVVALGRTVTF 334

Query: 425 SCNASGLPVPVIRWY--DSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGA 482
            C A+G P P I W    S  L+ S+  Q  +S SR                F +SQ G 
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSY--QPPQSSSR----------------FSVSQTG- 375

Query: 483 SSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSK 542
             L I  V +   G YIC+  N  G+   +A L V                         
Sbjct: 376 -DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV------------------------- 409

Query: 543 RDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGK 602
                T +++  P    P  +   P      +   D   +LS   T +P    ++WR  K
Sbjct: 410 -----TDVIADRP----PPVIRQGPVNQTVAV---DGTFVLSCVATGSP-VPTILWR--K 454

Query: 603 DGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAG 662
           DG L ++    + ++L++GV                ++  A+L  +  Y    +A + +G
Sbjct: 455 DGVL-VSTQDSRIKQLENGV---------------LQIRYAKLGDTGRYTC--IASTPSG 496

Query: 663 EGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPE 722
           E                ++ +        G+P  P      N               +P 
Sbjct: 497 E----------------ATWSAYIEVQEFGVPVQPPRPTDPNL--------------IPS 526

Query: 723 APDRPTISTASETSVYVTWIPRANGGSPITAFKVE-YKRMRTSNWLVAAEDIPPSKLSVE 781
           AP +P ++  S  +V ++W P  N G+  T++ +E +     S+W   AE++     +  
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSA 584

Query: 782 VRSLEPGSTYKFRVIAINHYGESFRSSASRPYQV-------VGFPNRFSSRPITGP--HI 832
           ++ L+P + Y F V A N YG S  S  S P +         G  ++   R +     H+
Sbjct: 585 IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHL 644

Query: 833 AYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDN-DSDY-KRDVVEGSKQWHM 890
                +S + I + WT    S     IQG+ I YRP+ +++ +SD+   +V   +K   +
Sbjct: 645 HNPTVLSSSSIEVHWTVDQQSQY---IQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV 701

Query: 891 IGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGG 950
           I  L+   +Y+IK + F       F+     ++++K      E P    S PP  +    
Sbjct: 702 IPDLRKGVNYEIKARPF-------FNEFQGADSEIKFAKTLEEAP----SAPPQGVTVSK 750

Query: 951 NVGPATS 957
           N G  T+
Sbjct: 751 NDGNGTA 757



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 19/123 (15%)

Query: 385 GIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGL 444
           G+  + S  RL  E+   F P I+  P    V+ G+  TL+C A G P P I WY     
Sbjct: 12  GLICLCSGSRLRQED---FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGER 68

Query: 445 ITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAAN 504
           + +      +   R  ++  P G     ++F+    G  S       +   G Y+C A N
Sbjct: 69  VETD-----KDDPRSHRMLLPSG----SLFFLRIVHGRKS-------RPDEGVYVCVARN 112

Query: 505 EHG 507
             G
Sbjct: 113 YLG 115


>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
           [Homo sapiens]
          Length = 1250

 Score =  156 bits (395), Expect = 1e-37
 Identities = 247/996 (24%), Positives = 375/996 (37%), Gaps = 212/996 (21%)

Query: 11  LLYVTLTILCSSVSSDLAPYFTSEPLSA----VQKLGGP---VVLHCS----AQPVTTRI 59
           LL +T  +L +     L P  T+  LS     +Q + GP    VL+CS    A    TR+
Sbjct: 12  LLALTFCLLAAR-GELLLPQETTVELSCGVGPLQVILGPEQAAVLNCSLGAAAAGPPTRV 70

Query: 60  SWLHNGKTLDGNLEHVKIH---QGTLTI---LSLNSS----------LLGYYQCLANNSI 103
           +W  +G TL   LEH  +H    G+L +   L+ N S          + G Y CLA+  +
Sbjct: 71  TWSKDGDTL---LEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPL 127

Query: 104 GAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEH 163
           G + S  A V +A L DF    +   T EE       C + E  P   + ++     L  
Sbjct: 128 GVLASQTAVVKLATLADFSLHPESQ-TVEENGTARFECHI-EGLPAPIITWEKDQVTLPE 185

Query: 164 STENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPI----GRKLLVSRPSSDD 219
                ++LP+G LQIL+V   D G Y+C A N        E +     R  L S    D 
Sbjct: 186 EPR-LIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDV 244

Query: 220 VHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLY--SHLAT 277
           V +  P ++    V+S   V +ECV S  P P V W++  QD  P S    +   ++L  
Sbjct: 245 VIVAAPENT---TVVSGQSVVMECVASADPTPFVSWVR--QDGKPISTDVIVLGRTNLLI 299

Query: 278 DSVDPADSGNYSCMAGN-KSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVH 336
            +  P  SG Y C A   ++ D       + VL   +I++  +    +  +T  F C   
Sbjct: 300 ANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRAS 359

Query: 337 GNPAPNCTWFHNAQPIHPSARHLTAGNG--LKISGVTVEDVGMYQCVADNGIGFMHSTGR 394
           G P P   W HN  P+ P+ R    G G  L I+ + ++D G YQCVA+N  G       
Sbjct: 360 GEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAG------- 412

Query: 395 LEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLR 454
                                        ++C A+ L V V       GL  S P++V  
Sbjct: 413 -----------------------------MACAAASLAVVV-----REGL-PSAPTRVTA 437

Query: 455 SKSRKSQL----SRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQ 510
           +    S +     RPE  + + + F        SLH Q        +Y  + A  + TT+
Sbjct: 438 TPLSSSAVLVAWERPEMHSEQIIGF--------SLHYQKARGMDNVEY--QFAVNNDTTE 487

Query: 511 AEASLMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVH-----PSAVE- 564
               L V   E NT  E   +  +     R           +S P  VH     PSA   
Sbjct: 488 ----LQVRDLEPNTDYEFYVVAYSQLGASR-----------TSTPALVHTLDDVPSAAPQ 532

Query: 565 -SAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVG 623
            S    N S I V   P+   PP                      N   VKY K++ G+G
Sbjct: 533 LSLSSPNPSDIRVAWLPL---PPSLS-------------------NGQVVKY-KIEYGLG 569

Query: 624 MLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKN 683
                 +  V G+E +L L  L+P+ +Y V + A +AAG G P+    +    +T S  N
Sbjct: 570 KEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPS----QWMHHRTPSMHN 625

Query: 684 TQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIP 743
                                             S VP AP    +    E S+ V+W P
Sbjct: 626 ---------------------------------QSHVPFAPAELKVQAKME-SLVVSWQP 651

Query: 744 RANGGSPITAFKVEYKRMRTSNWLVA----------AEDIPPSKLSVEVRSLE-----PG 788
             +  + I+ +K+ ++ +                  A D+ P +L  +V+  E     PG
Sbjct: 652 PPH-PTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPG 710

Query: 789 STYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSR-PITGPHIAYTEAVSDTQIMLKW 847
             Y+ +++A N + + + +      +    P+    R P   P   + E+ S T I L+W
Sbjct: 711 RLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRW 770

Query: 848 TYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCF 907
                      I  + + + P    N S        G     +IG L+P T Y+  +Q  
Sbjct: 771 K--KPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGED--ILIGGLKPFTKYEFAVQSH 826

Query: 908 NEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPP 943
               +  F +V+   T    +P     P  DL   P
Sbjct: 827 GVDMDGPFGSVVERST----LPDRPSTPPSDLRLSP 858


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  155 bits (393), Expect = 2e-37
 Identities = 222/947 (23%), Positives = 349/947 (36%), Gaps = 172/947 (18%)

Query: 10  TLLYVTLTILCSSV----------SSDLAPYFTSEPLSAVQKLGGPVVLHCSAQP-VTTR 58
           +LL  T  +LC  +            D  P     P   +   G P  L+C A+   T  
Sbjct: 2   SLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPT 61

Query: 59  ISWLHNGKTLDGNLEHVKIHQ-----GTLTILSL-----NSSLLGYYQCLANNSIGAIVS 108
           I W  +G+ ++ + +  + H+     G+L  L +     +    G Y C+A N +G  VS
Sbjct: 62  IEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVS 121

Query: 109 GPATVSVAVL-GDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTEN 167
             A++ VA+L  DF  +   V+ A  + A  + C+ P  +P+  + +K + K      E 
Sbjct: 122 RNASLEVALLRDDFRQNPTDVVVAAGEPA-ILECQPPRGHPEPTIYWK-KDKVRIDDKEE 179

Query: 168 YLILPSGNLQILNVSLEDKGSYKCAAYNPV----THQLKVEPIGRKLLVSRPSSDDVHIL 223
            + +  G L I N    D G Y C   N V    +   ++    R   + RP +      
Sbjct: 180 RISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQ----- 234

Query: 224 HPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPA 283
                    VL    V   C V G P P V W KD  D+  G    +    L        
Sbjct: 235 --------VVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMST 286

Query: 284 DSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNC 343
           D G Y C+A N+ G ++  +  + V          +DQIV+ G TV F C+  GNP P  
Sbjct: 287 DEGTYMCIAENRVGKME-ASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 345

Query: 344 TW---------FHNAQPIHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHSTG 393
            W         F N QP  P++R   +  G L I+ +   D G Y C A    G + +  
Sbjct: 346 FWQKEGSQNLLFPN-QPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKA 404

Query: 394 RLEIEN--DGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQ 451
           +LE+ +       P+I+  P +  +A      L C A+G P+PVI W             
Sbjct: 405 QLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWL------------ 452

Query: 452 VLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQA 511
                  K   + P     +P   +  Q    +L I+ +     G Y C A +  G T  
Sbjct: 453 -------KEGFTFP---GRDPRATIQEQ---GTLQIKNLRISDTGTYTCVATSSSGETSW 499

Query: 512 EASLMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNA 571
            A L                            D +E+G   S               KN 
Sbjct: 500 SAVL----------------------------DVTESGATIS---------------KNY 516

Query: 572 SGISVPDAPIILSPPQTH--TPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWH 629
               +P  P   S PQ    T ++  L W+ G  G LP +AY ++         +  SW 
Sbjct: 517 DLSDLPGPP---SKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIE----AFSQSVSNSWQ 569

Query: 630 TVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSP 689
           TV          +  L P+++Y  ++ A +  G   P+ +         +    TQ  SP
Sbjct: 570 TVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPM---------SDPVRTQDISP 620

Query: 690 PV-GIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGG 748
           P  G+    V  E      G VL     H+ V   P          T+V VTW       
Sbjct: 621 PAQGVDHRQVQKE-----LGDVLV--RLHNPVVLTP----------TTVQVTWTVDRQ-P 662

Query: 749 SPITAFKVEYKR----MRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGES 804
             I  ++V Y++      TS+W      +P  + +V V +L+ G TY+   I +  Y   
Sbjct: 663 QFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLV-NLKKGVTYE---IKVRPYFNE 718

Query: 805 FRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYI 864
           F+   S   + V       S P     +    + + T I + W   P  + N  IQ + I
Sbjct: 719 FQGMDSES-KTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI 777

Query: 865 YYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGG 911
           +    ++     +    V+ + +  +IG L P   Y +++      G
Sbjct: 778 WCLGNET---RFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAG 821



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 163/759 (21%), Positives = 273/759 (35%), Gaps = 124/759 (16%)

Query: 227 HSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSV------ 280
           H   + V    P TL C   G P P + W KDG+ +    +  R +  L           
Sbjct: 36  HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 95

Query: 281 -----DPADSGNYSCMAGNKSGDVKYVTYMVNV-LEHASISKGLQDQIVSLGATVHFTCD 334
                   D G+Y C+A N  G+       + V L      +   D +V+ G      C 
Sbjct: 96  VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQ 155

Query: 335 V-HGNPAPNCTWFHNAQPIHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHST 392
              G+P P   W  +   I      ++   G L IS     D GMY CV  N +G   S 
Sbjct: 156 PPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 215

Query: 393 GRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQV 452
                E     +P  +  P++  V + + V   C   G P P +RW              
Sbjct: 216 ---PAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW-------------- 258

Query: 453 LRSKSRKSQLSRPEG-LNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHG---- 507
                +K     P G  +++  Y         +L I+       G Y+C A N  G    
Sbjct: 259 -----KKDDADLPRGRYDIKDDY---------TLRIKKTMSTDEGTYMCIAENRVGKMEA 304

Query: 508 ----TTQAEASLMVVPFETNT-KAETVTLPDAAQNDDRS----KRDGSETGLLSSFPVKV 558
               T +A    +V P +    +  TVT P   + + +     +++GS+  L  + P + 
Sbjct: 305 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQP 364

Query: 559 HPS-AVESAPEKNASGISVPDAPI-----------ILSPPQTHTPDTYN-----LVWRAG 601
           +   +V    +   + I   DA             IL+  Q    D        ++ +  
Sbjct: 365 NSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGP 424

Query: 602 KDGGLPINAY-FVKYRKLDDGVGMLGSW--HTVRVPGSENELHLAELEPSSLYEVLMVAR 658
            +  L ++    +K +   D + ++ SW       PG +    + E              
Sbjct: 425 ANQTLAVDGTALLKCKATGDPLPVI-SWLKEGFTFPGRDPRATIQE-------------- 469

Query: 659 SAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHS 718
               +G   +   R S   T +   T +S    G   +  V +   +  G  ++ +   S
Sbjct: 470 ----QGTLQIKNLRISDTGTYTCVATSSS----GETSWSAVLDVTES--GATISKNYDLS 519

Query: 719 GVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSN-WLVAAEDIPPSK 777
            +P  P +P ++  ++ SV ++W P   G  P +A+ +E      SN W   A  +  + 
Sbjct: 520 DLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTL 579

Query: 778 LSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQ-------VVGFPNRFSSRPITGP 830
            +V  R L P + Y F V AIN  G S  S  S P +         G  +R   + +   
Sbjct: 580 YTV--RGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDV 637

Query: 831 HIAYTEAV--SDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTD--SDNDSDYKRDVVEGSK 886
            +     V  + T + + WT          IQG+ + YR T       S    D    ++
Sbjct: 638 LVRLHNPVVLTPTTVQVTWTV---DRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTE 694

Query: 887 QWHMIGHLQPETSYDIKMQ-CFNE--GGESEFSNVMICE 922
           +  ++ +L+   +Y+IK++  FNE  G +SE   V   E
Sbjct: 695 RSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTE 733


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  155 bits (391), Expect = 3e-37
 Identities = 217/921 (23%), Positives = 341/921 (37%), Gaps = 162/921 (17%)

Query: 26  DLAPYFTSEPLSAVQKLGGPVVLHCSAQP-VTTRISWLHNGKTLDGNLEHVKIHQ----- 79
           D  P     P   +   G P  L+C A+   T  I W  +G+ ++ + +  + H+     
Sbjct: 44  DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 103

Query: 80  GTLTILSL-----NSSLLGYYQCLANNSIGAIVSGPATVSVAVL-GDFGSSTKHVITAEE 133
           G+L  L +     +    G Y C+A N +G  VS  A++ VA+L  DF  +   V+ A  
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 163

Query: 134 KSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAA 193
           + A  + C+ P  +P+  + +K + K      E  + +  G L I N    D G Y C  
Sbjct: 164 EPA-ILECQPPRGHPEPTIYWK-KDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVG 221

Query: 194 YNPV----THQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVP 249
            N V    +   ++    R   + RP +               VL    V   C V G P
Sbjct: 222 TNMVGERDSDPAELTVFERPTFLRRPINQ-------------VVLEEEAVEFRCQVQGDP 268

Query: 250 APQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVL 309
            P V W KD  D+  G    +    L        D G Y C+A N+ G ++  +  + V 
Sbjct: 269 QPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKME-ASATLTVR 327

Query: 310 EHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTW---------FHNAQPIHPSARHLT 360
                    +DQIV+ G TV F C+  GNP P   W         F N QP  P++R   
Sbjct: 328 APPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPN-QPQQPNSRCSV 386

Query: 361 AGNG-LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIEN--DGGFKPVIITAPVSAKVA 417
           +  G L I+ +   D G Y C A    G + +  +LE+ +       P+I+  P +  +A
Sbjct: 387 SPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLA 446

Query: 418 DGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVL 477
                 L C A+G P+PVI W                    K   + P     +P   + 
Sbjct: 447 VDGTALLKCKATGDPLPVISWL-------------------KEGFTFP---GRDPRATIQ 484

Query: 478 SQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQN 537
            Q    +L I+ +     G Y C A +  G T   A L                      
Sbjct: 485 EQ---GTLQIKNLRISDTGTYTCVATSSSGETSWSAVL---------------------- 519

Query: 538 DDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTH--TPDTYN 595
                 D +E+G   S               KN     +P  P   S PQ    T ++  
Sbjct: 520 ------DVTESGATIS---------------KNYDLSDLPGPP---SKPQVTDVTKNSVT 555

Query: 596 LVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLM 655
           L W+ G  G LP +AY ++         +  SW TV          +  L P+++Y  ++
Sbjct: 556 LSWQPGTPGTLPASAYIIE----AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMV 611

Query: 656 VARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPV-GIPKYPVVSEAANNNFGVVLTDS 714
            A +  G   P+ +         +    TQ  SPP  G+    V  E      G VL   
Sbjct: 612 RAINPQGLSDPSPM---------SDPVRTQDISPPAQGVDHRQVQKE-----LGDVLV-- 655

Query: 715 SRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKR----MRTSNWLVAA 770
             H+ V   P          T+V VTW         I  ++V Y++      TS+W    
Sbjct: 656 RLHNPVVLTP----------TTVQVTWTVDRQ-PQFIQGYRVMYRQTSGLQATSSWQNLD 704

Query: 771 EDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGP 830
             +P  + +V V +L+ G TY+   I +  Y   F+   S   + V       S P    
Sbjct: 705 AKVPTERSAVLV-NLKKGVTYE---IKVRPYFNEFQGMDSES-KTVRTTEEAPSAPPQSV 759

Query: 831 HIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHM 890
            +    + + T I + W   P  + N  IQ + I+    ++     +    V+ + +  +
Sbjct: 760 TVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNET---RFHINKTVDAAIRSVI 816

Query: 891 IGHLQPETSYDIKMQCFNEGG 911
           IG L P   Y +++      G
Sbjct: 817 IGGLFPGIQYRVEVAASTSAG 837



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 163/759 (21%), Positives = 273/759 (35%), Gaps = 124/759 (16%)

Query: 227 HSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSV------ 280
           H   + V    P TL C   G P P + W KDG+ +    +  R +  L           
Sbjct: 52  HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 111

Query: 281 -----DPADSGNYSCMAGNKSGDVKYVTYMVNV-LEHASISKGLQDQIVSLGATVHFTCD 334
                   D G+Y C+A N  G+       + V L      +   D +V+ G      C 
Sbjct: 112 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQ 171

Query: 335 V-HGNPAPNCTWFHNAQPIHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHST 392
              G+P P   W  +   I      ++   G L IS     D GMY CV  N +G   S 
Sbjct: 172 PPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 231

Query: 393 GRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQV 452
                E     +P  +  P++  V + + V   C   G P P +RW              
Sbjct: 232 ---PAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW-------------- 274

Query: 453 LRSKSRKSQLSRPEG-LNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHG---- 507
                +K     P G  +++  Y         +L I+       G Y+C A N  G    
Sbjct: 275 -----KKDDADLPRGRYDIKDDY---------TLRIKKTMSTDEGTYMCIAENRVGKMEA 320

Query: 508 ----TTQAEASLMVVPFETNT-KAETVTLPDAAQNDDRS----KRDGSETGLLSSFPVKV 558
               T +A    +V P +    +  TVT P   + + +     +++GS+  L  + P + 
Sbjct: 321 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQP 380

Query: 559 HPS-AVESAPEKNASGISVPDAPI-----------ILSPPQTHTPDTYN-----LVWRAG 601
           +   +V    +   + I   DA             IL+  Q    D        ++ +  
Sbjct: 381 NSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGP 440

Query: 602 KDGGLPINAY-FVKYRKLDDGVGMLGSW--HTVRVPGSENELHLAELEPSSLYEVLMVAR 658
            +  L ++    +K +   D + ++ SW       PG +    + E              
Sbjct: 441 ANQTLAVDGTALLKCKATGDPLPVI-SWLKEGFTFPGRDPRATIQE-------------- 485

Query: 659 SAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHS 718
               +G   +   R S   T +   T +S    G   +  V +   +  G  ++ +   S
Sbjct: 486 ----QGTLQIKNLRISDTGTYTCVATSSS----GETSWSAVLDVTES--GATISKNYDLS 535

Query: 719 GVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSN-WLVAAEDIPPSK 777
            +P  P +P ++  ++ SV ++W P   G  P +A+ +E      SN W   A  +  + 
Sbjct: 536 DLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTL 595

Query: 778 LSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQ-------VVGFPNRFSSRPITGP 830
            +V  R L P + Y F V AIN  G S  S  S P +         G  +R   + +   
Sbjct: 596 YTV--RGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDV 653

Query: 831 HIAYTEAV--SDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTD--SDNDSDYKRDVVEGSK 886
            +     V  + T + + WT          IQG+ + YR T       S    D    ++
Sbjct: 654 LVRLHNPVVLTPTTVQVTWTV---DRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTE 710

Query: 887 QWHMIGHLQPETSYDIKMQ-CFNE--GGESEFSNVMICE 922
           +  ++ +L+   +Y+IK++  FNE  G +SE   V   E
Sbjct: 711 RSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTE 749


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score =  151 bits (381), Expect = 4e-36
 Identities = 151/536 (28%), Positives = 228/536 (42%), Gaps = 70/536 (13%)

Query: 6   GPLCTLLYVTLTILCSSVSSDLAPYFTSEPL-SAVQKLGGPVVLHCSAQPV-TTRISWLH 63
           G L   L     I  +    D++PYF +EP+ + V   G  +VL C A+        WLH
Sbjct: 3   GLLIWTLLALHQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLH 62

Query: 64  NGKTLDG-NLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFG 122
           N + L   +LE+         I SL+ +  G+Y+C+  N +GA++     V VA +G F 
Sbjct: 63  NNRELTKFSLEY------RYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFE 116

Query: 123 SSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVS 182
              KH   +  ++A     R+  S P+ +V +   G+ +  S+   + L    L IL+  
Sbjct: 117 EGEKHQSVSHGEAAVIRAPRI-ASFPQPQVTWFRDGRKIPPSSRIAITL-ENTLVILSTV 174

Query: 183 LEDKGSYKCAAYN----------PVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALA 232
             D G Y   A N          P+T  L VE +G       P+     I+ P ++  +A
Sbjct: 175 APDAGRYYVQAVNDKNGDNKTSQPIT--LTVENVGGPADPIAPTI----IIPPKNTSVVA 228

Query: 233 VLSRSPVTLECVVSGVPAPQVY--WLKDGQDIAPG-SNWRRLYSHLATDSVDPADSGNYS 289
               S VTLECV +  P  +++  W KDG  ++ G S+  R    L   +   +D+G Y 
Sbjct: 229 --GTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNR---RLTIPNPTGSDAGYYE 283

Query: 290 CMAGNKSGDVKYVT--YMVNVLEHASISKGLQDQIVS-LGATVHFTCDVHGNPAPNCTWF 346
           C A  +S  V  V     ++VLE     K  +  I + +   V   C   G P P+ TW+
Sbjct: 284 CEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWY 343

Query: 347 HNAQPIHPSARHLTA-----GNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDG 401
            +A  +      LT        GL+ISG+  +D GM+QC A N  G + ++  L + +  
Sbjct: 344 KDAAVV--EVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTS-- 399

Query: 402 GFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQ 461
              P I   P+ + V DG  V L+C  SG P P I W     ++ S   Q+ R    +S 
Sbjct: 400 -IAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLES- 457

Query: 462 LSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMV 517
                                 SL I       AG Y C A N  G  +A A L+V
Sbjct: 458 ---------------------GSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 492



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 187/918 (20%), Positives = 298/918 (32%), Gaps = 194/918 (21%)

Query: 58  RISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAI--VSGPATVSV 115
           +++W  +G+ +  +       + TL ILS  +   G Y   A N        S P T++V
Sbjct: 144 QVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTV 203

Query: 116 AVLGDFGSSTKHVITAEEKSAGFIGCR-------VPESNP--KAEVRYKIRGKWLEHSTE 166
             +G         I    K+   +          V  + P  K  + +K  G  L     
Sbjct: 204 ENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGIS 263

Query: 167 NYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPT 226
           ++    +  L I N +  D G Y+C A   V     V  + R   +S        +L P 
Sbjct: 264 DH----NRRLTIPNPTGSDAGYYECEA---VLRSSSVPSVVRGAYLS--------VLEPP 308

Query: 227 H-----SQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWR---RLYSHLATD 278
                  + +       V + C   GVP P + W KD   +      R   R    L   
Sbjct: 309 QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQIS 368

Query: 279 SVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGN 338
            + P D+G + C A N +G+V+  TY+       +I++G  D  V  G +V   C+  G 
Sbjct: 369 GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA 428

Query: 339 PAPNCTWFHNAQPIHPSARHL-----TAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTG 393
           P P  TW    + +   +  L          L IS   + D G Y C+A N  G   ++ 
Sbjct: 429 PRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 488

Query: 394 RLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRW-YDSHGL---ITSHP 449
            L +      +  I   P    V  G   ++ C  +  P   IR+ ++  G      SHP
Sbjct: 489 DLVV----WARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHP 544

Query: 450 SQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTT 509
                    + +L R                   SLHI        G Y C   +  G  
Sbjct: 545 ---------RIRLDR-----------------NGSLHISQTWSGDIGTYTCRVISAGGND 578

Query: 510 QAEASLMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEK 569
              A L V             LP A +                      HP A  S  E+
Sbjct: 579 SRSAHLRV-----------RQLPHAPE----------------------HPVATLSTVER 605

Query: 570 NASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWH 629
            A                       NL W    DG  P+  Y ++  + +    +L    
Sbjct: 606 RA----------------------INLTWTKPFDGNSPLIRYILEMSENNAPWTVL---- 639

Query: 630 TVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSP 689
              V      + +  L P+  Y+  + A +  G+GQ               SK+T+    
Sbjct: 640 LASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQ--------------FSKDTER--- 682

Query: 690 PVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTA-SETSVYVTW--IPRAN 746
            V +P+ P                       P AP +  I++  +  S+ + W   P ++
Sbjct: 683 -VSLPEEP-----------------------PTAPPQNVIASGRTNQSIMIQWQPPPESH 718

Query: 747 GGSPITAFKVEY--KRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGES 804
               +  + + Y    +          D   + L +E   L   + Y+  V A N  G  
Sbjct: 719 QNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLE--DLIIWTNYEIEVAAYNSAGLG 776

Query: 805 FRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYI 864
             SS    + + G P          P   + EA + T I   W        N   QG+ +
Sbjct: 777 VYSSKVTEWTLQGVPT-------VPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKL 829

Query: 865 YYRPTDSDNDSDY--KRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICE 922
                + + +      R   + S     +  L+  T Y   + CF   G+   S   +  
Sbjct: 830 IAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVR 889

Query: 923 TKVKRVPGASEYPVKDLS 940
           T  + VPG    PV  LS
Sbjct: 890 TH-EDVPG----PVGHLS 902



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 86/401 (21%), Positives = 156/401 (38%), Gaps = 72/401 (17%)

Query: 548  TGL--LSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPP-----QTHTPDTYNLVWRA 600
            TGL  L+++ ++V     +   + +AS IS    P +  PP         P +  L +R 
Sbjct: 956  TGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRP 1015

Query: 601  GKDGGLPINAYFVKYRKLDDGVGMLGS---WHTVRVPGSENE---LHLAELEPSSLYEVL 654
            G DG   I+ + V+ +     VG++G    W  +    +E +   + + +L P + Y   
Sbjct: 1016 GYDGKTSISRWLVEAQ-----VGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFR 1070

Query: 655  MVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDS 714
            M   +  G   P+            S K     +PP                        
Sbjct: 1071 MRQVNIVGTSPPSQ----------PSRKIQTLQAPP------------------------ 1096

Query: 715  SRHSGVPEAPDRPTISTASETSVYVTWIP----RANGGSPITAFKVEYKRMRTSNWLVAA 770
                    AP   ++ TASETS+++ W+P      NG      +K++Y R       ++ 
Sbjct: 1097 ------DMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSH 1150

Query: 771  EDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGP 830
                  +    +  LE  + Y+ +V A N  G       S P+          S P +GP
Sbjct: 1151 VVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-------SGPWSQTVVGRTRESVPSSGP 1203

Query: 831  HIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEG-SKQWH 889
                  A + + ++++W+ +P ++ N  + G+ + Y+  DSD    +   +VEG S +  
Sbjct: 1204 TNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFW--LVEGNSSRSA 1261

Query: 890  MIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPG 930
             +  L     Y++++  F   G+   S+  I E  +  VPG
Sbjct: 1262 QLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPG 1302



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 87/337 (25%), Positives = 136/337 (40%), Gaps = 37/337 (10%)

Query: 633  VPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVG 692
            VPG    L  +E+  +SL     V+    GE    +  +R S E+   +        P  
Sbjct: 894  VPGPVGHLSFSEILDTSL----KVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNV 949

Query: 693  IPKYPVVSEAANNNFGVVL-----------TDSSRHSGVP-EAPDRPT---ISTASETSV 737
              +Y V    A   + + +           + S+  SGVP E P  PT   IS     SV
Sbjct: 950  TLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSV 1009

Query: 738  YVTWIPRANGGSPITAFKVEYKRM---RTSNWLVAAE-DIPPSKLSVEVRSLEPGSTYKF 793
             + + P  +G + I+ + VE +         WL+  +    P   S+EV  L P + Y F
Sbjct: 1010 TLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSF 1069

Query: 794  RVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSS 853
            R+  +N  G S  S  SR  Q +  P      P   P        S+T + L+W  +P  
Sbjct: 1070 RMRQVNIVGTSPPSQPSRKIQTLQAP------PDMAPANVSLRTASETSLWLRWMPLPEM 1123

Query: 854  --NNNTPIQGFYIYYRPTDSDND--SDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNE 909
              N N    G+ I Y  +D      S   +D VE     + I  L+  T Y +++Q FN 
Sbjct: 1124 EYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERD---YTIEDLEEWTEYRVQVQAFNA 1180

Query: 910  GGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSL 946
             G   +S  ++  T+ + VP +    V  L+T  +S+
Sbjct: 1181 IGSGPWSQTVVGRTR-ESVPSSGPTNVSALATTSSSM 1216



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 51/218 (23%), Positives = 90/218 (41%), Gaps = 28/218 (12%)

Query: 721  PEAPDRPTISTAS--ETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKL 778
            P+ P RP +        SV ++W P ++G SP+  + ++ + + +  W + +  +  +  
Sbjct: 1400 PQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNAS 1459

Query: 779  SVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAV 838
            S  V  L+P ++YKFRV A N  G+S  S  S     +       + P   P I      
Sbjct: 1460 SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTL------QAAPDEAPTILSVTPH 1513

Query: 839  SDTQIMLKWTYIPSSNNNTPIQGFYIYYR-------------------PTDSDNDSDYK- 878
            + T ++++W        N  + GF I YR                    T ++  S Y  
Sbjct: 1514 TTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSM 1573

Query: 879  RDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFS 916
            R++   S   + + +L     Y+I+M  +N  GE   S
Sbjct: 1574 RNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSS 1611



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 53/210 (25%), Positives = 88/210 (41%), Gaps = 8/210 (3%)

Query: 720  VPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLS 779
            VP  P          TSV + W P A     I A+++ ++   T+      E + PS   
Sbjct: 1300 VPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQ 1359

Query: 780  VEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVS 839
                 L+P S Y FR+ A    G    + A     VV    R   +P + P +   E V 
Sbjct: 1360 YTATGLKPESVYLFRITAQTRKGWGEAAEA----LVVTTEKRDRPQPPSRP-MVQQEDVR 1414

Query: 840  DTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETS 899
               ++L W   P S+  +P++ + I  R   S   + +   V   +  + ++  L+P TS
Sbjct: 1415 ARSVLLSWE--PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSF-IVDRLKPFTS 1471

Query: 900  YDIKMQCFNEGGESEFSNVMICETKVKRVP 929
            Y  +++  N+ G+SEFS      T ++  P
Sbjct: 1472 YKFRVKATNDIGDSEFSEESESLTTLQAAP 1501



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 32/95 (33%), Positives = 47/95 (49%), Gaps = 3/95 (3%)

Query: 719  GVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPP--S 776
            G P  P  P I   S +++ + W     G  PIT + +E +      W +  +DIP   S
Sbjct: 1823 GAPGPPGVPIIVRYS-SAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881

Query: 777  KLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASR 811
              +  +  L+PG +Y FRVIA+N YG    SS S+
Sbjct: 1882 SYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQ 1916



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 74/372 (19%), Positives = 135/372 (36%), Gaps = 80/372 (21%)

Query: 596  LVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLM 655
            L W  G DG  P+  Y ++ R+L  G   L   H+  V  + +   +  L+P + Y+  +
Sbjct: 1420 LSWEPGSDGLSPVRYYTIQTRELPSGRWAL---HSASVSHNASSFIVDRLKPFTSYKFRV 1476

Query: 656  VARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSS 715
             A +  G+ +          E++ S    QA+                            
Sbjct: 1477 KATNDIGDSE--------FSEESESLTTLQAAPD-------------------------- 1502

Query: 716  RHSGVPEAPDRPTISTASETSVYVTWIPRANG--GSPITAFKVEYKRMRT---------- 763
                  EAP   +++  + TSV + W P A       +  F++ Y+ +            
Sbjct: 1503 ------EAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRG 1556

Query: 764  -----SNW-----LVAAEDIP-PSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRP 812
                 + W     + +  ++  PS    E+ +L     Y+ R+   N  GE     +S P
Sbjct: 1557 INNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG---PSSPP 1613

Query: 813  YQV-VGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDS 871
             +V VG      + P   P        + TQ+ + W   P  + N  IQG+ IY+     
Sbjct: 1614 QEVFVG-----EAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQR 1668

Query: 872  DNDSDYKRD--VVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVP 929
             N ++  +   + E S +   + +L   T+Y + +  FN  G+   S     +T+     
Sbjct: 1669 GNLTERVKTLFLAENSVK---LKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPS 1725

Query: 930  GASEYPVKDLST 941
              S     +L+T
Sbjct: 1726 APSSVKFSELTT 1737



 Score = 37.4 bits (85), Expect = 0.091
 Identities = 60/283 (21%), Positives = 105/283 (37%), Gaps = 57/283 (20%)

Query: 712  TDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNW---LV 768
            T        P AP     S  + TSV V+W         +  +++ Y+     +    +V
Sbjct: 1715 TQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIV 1774

Query: 769  AAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPIT 828
              +    S L ++V+ L  G TY+FR+ A     ++F         V   P   +  P  
Sbjct: 1775 TVDVKGNSPLWLKVKDLAEGVTYRFRIRA-----KTFTYGPEIEANVTTGPGEGAPGPPG 1829

Query: 829  GPHIA-YTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVV-EGSK 886
             P I  Y+ A++     + W+         PI  + I  RP+D        +D+  E S 
Sbjct: 1830 VPIIVRYSSAIA-----IHWS--SGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSS 1882

Query: 887  QWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSL 946
                +  L+P  SYD                         RV   ++Y     S+P  S+
Sbjct: 1883 YTFSMDILKPGVSYDF------------------------RVIAVNDYGFGTPSSPSQSV 1918

Query: 947  GSGGNVGPATSPARSSDMLY-----LIVGCVLGVMVLILMVFI 984
                       PA+ ++  Y     L+V  ++G++ ++L+VF+
Sbjct: 1919 -----------PAQKANPFYEEWWFLVVIALVGLIFILLLVFV 1950


>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
          Length = 1007

 Score =  145 bits (366), Expect = 2e-34
 Identities = 209/999 (20%), Positives = 360/999 (36%), Gaps = 205/999 (20%)

Query: 11  LLYVTLTILCSSVSSDLAPYFTSEPLSAV---QKLGGPVVLHCSAQPVTTRI-SWLHNGK 66
           ++ +T  +  S       P F  +P++ +   + L G V L+C A+     +  W  N  
Sbjct: 12  IISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNG 71

Query: 67  TLDGNLEHVKIHQGTLTILSLNSSL-LGYYQCLANNSIGAIVSGPATVSVAVLGDFGSST 125
            +D   +   +  G L I + +     G Y CLA+N+ G + S  AT+S   L  F    
Sbjct: 72  DVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEE 131

Query: 126 KHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILP--------SGNLQ 177
           +  +  +E     + C  P   P  ++ Y+    WL +    ++ +         +GNL 
Sbjct: 132 RPEVRVKEGKGMVLLCDPPYHFPD-DLSYR----WLLNEFPVFITMDKRRFVSQTNGNLY 186

Query: 178 ILNVSLEDKGSYKCAAYNPVTHQ------LKVEPIGRKLLVSRPSSDDVHILHPTHSQAL 231
           I NV   DKG+Y C   +P   +      + + PI  +   ++P   D+ +      + +
Sbjct: 187 IANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPER--TTKPYPADIVV----QFKDV 240

Query: 232 AVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCM 291
             L    VTLEC   G P P + W K  + +   +      + L   ++   D G Y C 
Sbjct: 241 YALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECE 300

Query: 292 AGNKSGDVK-----YVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWF 346
           A N  G  K     YV      +EH      + D  V +G+ +++ C   G P P   W 
Sbjct: 301 AENIRGKDKHQARIYVQAFPEWVEH------INDTEVDIGSDLYWPCVATGKPIPTIRWL 354

Query: 347 HNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPV 406
            N    H           L++  VT E+ GMYQC+A+N  G +++   L+I       P 
Sbjct: 355 KNGYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKIL---ALAPT 403

Query: 407 IITAPVSAKV--ADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSR 464
               P+  K+  A G  V + C     P P   W        S  ++ L + SR      
Sbjct: 404 FEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSW--------SKGTEWLVNSSR------ 449

Query: 465 PEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMV------- 517
                      ++ + G  SL I  +T+   G Y C A N  G   +  +L++       
Sbjct: 450 ----------ILIWEDG--SLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRII 497

Query: 518 -VPFETN-TKAETVTLPDAAQND----------------DRSKR----------DGSETG 549
             P   + T  E  T+  AA  D                D +K           D +   
Sbjct: 498 LAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGEL 557

Query: 550 LLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPP--------QTHTPDTYNLVWRAG 601
           L+ +  +K H        +      S     ++  PP        +     +  L W  G
Sbjct: 558 LIRNAQLK-HAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRG 616

Query: 602 KDGGLPINAYFVKYRKLDDGVGMLGSWHTVR-----VPGSENELHLAELEPSSLYEVLMV 656
            D   PI+ Y ++ + +     +   W   +     + G+       +L P   YE  +V
Sbjct: 617 SDNHSPISKYTIQTKTI-----LSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVV 671

Query: 657 ARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSR 716
           A +  G G+P++ + R           T  ++P V                         
Sbjct: 672 ATNTLGRGEPSIPSNRI---------KTDGAAPNV------------------------- 697

Query: 717 HSGVPEAPDRPTISTASETSVYVTWIPRA------NGGSPITAFK----VEYKRMRTSNW 766
                 AP            + +TW P +      N    I AFK     E+K++  +N 
Sbjct: 698 ------APSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTN- 750

Query: 767 LVAAEDIPPSKLSV-EVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSR 825
                  P +   V +  ++ P + ++ +V A N+ G+        PY +V   N     
Sbjct: 751 -------PDTGRYVHKDETMSPSTAFQVKVKAFNNKGDG-------PYSLVAVINSAQDA 796

Query: 826 PITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGS 885
           P   P     + +S ++I + W ++        ++ + I Y     D +    R  V   
Sbjct: 797 PSEAPTEVGVKVLSSSEISVHWEHVLEK----IVESYQIRYWAA-HDKEEAANRVQVTSQ 851

Query: 886 KQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETK 924
           +    + +L P+T Y I++   N  G    S+++   TK
Sbjct: 852 EYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTK 890


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
           sapiens]
          Length = 1248

 Score =  144 bits (364), Expect = 4e-34
 Identities = 201/905 (22%), Positives = 332/905 (36%), Gaps = 151/905 (16%)

Query: 78  HQGTLTILSLNSSLL----GYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEE 133
           H G+ TI   NS+      G Y+C A+N +G  +S    +       +   T   +  EE
Sbjct: 86  HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 145

Query: 134 KSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLIL-PSGNLQILNVSLEDKGS-YKC 191
             +  + C  P S     + Y +  K L    +  + +  +GNL   NV   D  S Y C
Sbjct: 146 GESVVLPCNPPPSAEPLRI-YWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 204

Query: 192 AAYNPVTHQL-KVEPIGRKLLVSRPSSD-DVHILHPTHSQA-LAVLSRSPVTLECVVSGV 248
            A+ P T  + + EPI  ++  +    D    +L PT+S + L  L   P+ LEC+  G 
Sbjct: 205 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 264

Query: 249 PAPQVYWLK-DGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVN 307
           P P + WL+  G   A    ++     L    V   D G Y C+A N  G  ++  Y+  
Sbjct: 265 PTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTV 324

Query: 308 VLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSA---RHLTAGNG 364
                 + K  Q  +   G T    C V G P P  TW  N  P+   A   ++      
Sbjct: 325 EAAPYWLHKP-QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGA 383

Query: 365 LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVA-DGDFVT 423
           L +S V   D  + QC A N  G + +   + +         I+TA     +A  G    
Sbjct: 384 LILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQ---LPAKILTADNQTYMAVQGSTAY 440

Query: 424 LSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGAS 483
           L C A G PVP ++W D  G      + VL+ +                 +F  +     
Sbjct: 441 LLCKAFGAPVPSVQWLDEDG------TTVLQDER----------------FFPYAN---G 475

Query: 484 SLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVV--------PFET-NTKAETVTLPDA 534
           +L I+ +     G+Y C AAN+       A+L V         P  T   K   VT    
Sbjct: 476 TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQ 535

Query: 535 AQNDDRSK---------RDGSETGLLSSFPVK-----VHP-----------------SAV 563
           A  D   +         RD  E G    + ++     +H                    V
Sbjct: 536 ASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVV 595

Query: 564 ESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVG 623
           ES  +    G   P   ++LS     T     + W   +D   PI  Y +++   +D   
Sbjct: 596 ESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEF---EDKEM 652

Query: 624 MLGSWHTV-RVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSK 682
               W+++ +VPG++    L +L P   Y   + A +  G G+P+ ++      + A  K
Sbjct: 653 APEKWYSLGKVPGNQTSTTL-KLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEK 711

Query: 683 NTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWI 742
           N             PV  +   N                             T++ +TW 
Sbjct: 712 N-------------PVDVKGEGN---------------------------ETTNMVITWK 731

Query: 743 PR--ANGGSPITAFKVEYKRMRTSN-WLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAIN 799
           P    +  +P   ++V+++   T   W    E I      V V +      Y+ +V A+N
Sbjct: 732 PLRWMDWNAPQVQYRVQWRPQGTRGPW---QEQIVSDPFLV-VSNTSTFVPYEIKVQAVN 787

Query: 800 HYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPI 859
             G+        P   +G+       P   P +   E ++ + +++KW  +  +     +
Sbjct: 788 SQGK-----GPEPQVTIGYSG--EDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHL 840

Query: 860 QGFYIYYRPTDSDNDSDYK-----RDVVEGSKQWHMIGHLQPETSYDIKMQCFN---EGG 911
           +G+ + Y    S      +       VV  +    ++  L+P +SY +++Q FN    G 
Sbjct: 841 RGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGP 900

Query: 912 ESEFS 916
            SEF+
Sbjct: 901 ASEFT 905



 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 102/393 (25%), Positives = 159/393 (40%), Gaps = 27/393 (6%)

Query: 27  LAPYFTSEPLSAVQKLGGPVVLHCSAQPVTT-RISWLHNGKTLDGNLEHVKIHQGTLTIL 85
           L P  +S  L A+Q  G P+VL C A+   T  I WL     +  +    + H  TL +L
Sbjct: 238 LFPTNSSSHLVALQ--GQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLL 295

Query: 86  SLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPE 145
            +     G Y+CLA NS+G+          A          H+    E +   + C+V +
Sbjct: 296 KVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETAR--LDCQV-Q 352

Query: 146 SNPKAEVRYKIRGKWLEH-STENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVE 204
             P+ EV ++I G  +E  + +    +  G L + NV   D    +C A N   H L + 
Sbjct: 353 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARN--RHGLLLA 410

Query: 205 PIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWL-KDGQDIA 263
                 +V  P+      +    +Q    +  S   L C   G P P V WL +DG  + 
Sbjct: 411 N-AYIYVVQLPAK-----ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL 464

Query: 264 PGSN-WRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVN--VLEHASISKGLQD 320
                +      L    +   D+G Y C+A N   D   VT M N  V +   I++G + 
Sbjct: 465 QDERFFPYANGTLGIRDLQANDTGRYFCLAAN---DQNNVTIMANLKVKDATQITQGPRS 521

Query: 321 QIVSLGATVHFTCDVHGNPA--PNCTW---FHNAQPIHPSARHLTAGNGLKISGVTVEDV 375
            I   G+ V FTC    +P+  P+ TW     + Q +  S ++      L I  +   D 
Sbjct: 522 TIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 581

Query: 376 GMYQCVADNGIGFMHSTGRLEIENDGGFKPVII 408
           G Y CVA   +  + S  +L +    G  P ++
Sbjct: 582 GNYSCVASTELDVVESRAQLLVVGSPGPVPRLV 614



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 46/190 (24%), Positives = 81/190 (42%), Gaps = 14/190 (7%)

Query: 733 SETSVYVTWIPRANGGSPITAFKVEY--KRMRTSNWLVAAEDIPPSKLSVEVRSLEPGST 790
           +++ V V+W P  +  +PI  + +E+  K M    W    + +P ++ S  ++ L P   
Sbjct: 622 TQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGK-VPGNQTSTTLK-LSPYVH 679

Query: 791 YKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYI 850
           Y FRV AIN YG    S  S   + V  P    + P   P     E    T +++ W  +
Sbjct: 680 YTFRVTAINKYGPGEPSPVS---ETVVTP---EAAPEKNPVDVKGEGNETTNMVITWKPL 733

Query: 851 PSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEG 910
              + N P   + + +RP        ++  +V  S  + ++ +      Y+IK+Q  N  
Sbjct: 734 RWMDWNAPQVQYRVQWRP--QGTRGPWQEQIV--SDPFLVVSNTSTFVPYEIKVQAVNSQ 789

Query: 911 GESEFSNVMI 920
           G+     V I
Sbjct: 790 GKGPEPQVTI 799


>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
           sapiens]
          Length = 1253

 Score =  144 bits (364), Expect = 4e-34
 Identities = 201/905 (22%), Positives = 332/905 (36%), Gaps = 151/905 (16%)

Query: 78  HQGTLTILSLNSSLL----GYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEE 133
           H G+ TI   NS+      G Y+C A+N +G  +S    +       +   T   +  EE
Sbjct: 91  HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 150

Query: 134 KSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLIL-PSGNLQILNVSLEDKGS-YKC 191
             +  + C  P S     + Y +  K L    +  + +  +GNL   NV   D  S Y C
Sbjct: 151 GESVVLPCNPPPSAEPLRI-YWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 209

Query: 192 AAYNPVTHQL-KVEPIGRKLLVSRPSSD-DVHILHPTHSQA-LAVLSRSPVTLECVVSGV 248
            A+ P T  + + EPI  ++  +    D    +L PT+S + L  L   P+ LEC+  G 
Sbjct: 210 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 269

Query: 249 PAPQVYWLK-DGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVN 307
           P P + WL+  G   A    ++     L    V   D G Y C+A N  G  ++  Y+  
Sbjct: 270 PTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTV 329

Query: 308 VLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSA---RHLTAGNG 364
                 + K  Q  +   G T    C V G P P  TW  N  P+   A   ++      
Sbjct: 330 EAAPYWLHKP-QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGA 388

Query: 365 LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVA-DGDFVT 423
           L +S V   D  + QC A N  G + +   + +         I+TA     +A  G    
Sbjct: 389 LILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQ---LPAKILTADNQTYMAVQGSTAY 445

Query: 424 LSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGAS 483
           L C A G PVP ++W D  G      + VL+ +                 +F  +     
Sbjct: 446 LLCKAFGAPVPSVQWLDEDG------TTVLQDER----------------FFPYAN---G 480

Query: 484 SLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVV--------PFET-NTKAETVTLPDA 534
           +L I+ +     G+Y C AAN+       A+L V         P  T   K   VT    
Sbjct: 481 TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQ 540

Query: 535 AQNDDRSK---------RDGSETGLLSSFPVK-----VHP-----------------SAV 563
           A  D   +         RD  E G    + ++     +H                    V
Sbjct: 541 ASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVV 600

Query: 564 ESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVG 623
           ES  +    G   P   ++LS     T     + W   +D   PI  Y +++   +D   
Sbjct: 601 ESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEF---EDKEM 657

Query: 624 MLGSWHTV-RVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSK 682
               W+++ +VPG++    L +L P   Y   + A +  G G+P+ ++      + A  K
Sbjct: 658 APEKWYSLGKVPGNQTSTTL-KLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEK 716

Query: 683 NTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWI 742
           N             PV  +   N                             T++ +TW 
Sbjct: 717 N-------------PVDVKGEGN---------------------------ETTNMVITWK 736

Query: 743 PR--ANGGSPITAFKVEYKRMRTSN-WLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAIN 799
           P    +  +P   ++V+++   T   W    E I      V V +      Y+ +V A+N
Sbjct: 737 PLRWMDWNAPQVQYRVQWRPQGTRGPW---QEQIVSDPFLV-VSNTSTFVPYEIKVQAVN 792

Query: 800 HYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPI 859
             G+        P   +G+       P   P +   E ++ + +++KW  +  +     +
Sbjct: 793 SQGK-----GPEPQVTIGYSG--EDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHL 845

Query: 860 QGFYIYYRPTDSDNDSDYK-----RDVVEGSKQWHMIGHLQPETSYDIKMQCFN---EGG 911
           +G+ + Y    S      +       VV  +    ++  L+P +SY +++Q FN    G 
Sbjct: 846 RGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGP 905

Query: 912 ESEFS 916
            SEF+
Sbjct: 906 ASEFT 910



 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 102/393 (25%), Positives = 159/393 (40%), Gaps = 27/393 (6%)

Query: 27  LAPYFTSEPLSAVQKLGGPVVLHCSAQPVTT-RISWLHNGKTLDGNLEHVKIHQGTLTIL 85
           L P  +S  L A+Q  G P+VL C A+   T  I WL     +  +    + H  TL +L
Sbjct: 243 LFPTNSSSHLVALQ--GQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLL 300

Query: 86  SLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPE 145
            +     G Y+CLA NS+G+          A          H+    E +   + C+V +
Sbjct: 301 KVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETAR--LDCQV-Q 357

Query: 146 SNPKAEVRYKIRGKWLEH-STENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVE 204
             P+ EV ++I G  +E  + +    +  G L + NV   D    +C A N   H L + 
Sbjct: 358 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARN--RHGLLLA 415

Query: 205 PIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWL-KDGQDIA 263
                 +V  P+      +    +Q    +  S   L C   G P P V WL +DG  + 
Sbjct: 416 N-AYIYVVQLPAK-----ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL 469

Query: 264 PGSN-WRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVN--VLEHASISKGLQD 320
                +      L    +   D+G Y C+A N   D   VT M N  V +   I++G + 
Sbjct: 470 QDERFFPYANGTLGIRDLQANDTGRYFCLAAN---DQNNVTIMANLKVKDATQITQGPRS 526

Query: 321 QIVSLGATVHFTCDVHGNPA--PNCTW---FHNAQPIHPSARHLTAGNGLKISGVTVEDV 375
            I   G+ V FTC    +P+  P+ TW     + Q +  S ++      L I  +   D 
Sbjct: 527 TIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 586

Query: 376 GMYQCVADNGIGFMHSTGRLEIENDGGFKPVII 408
           G Y CVA   +  + S  +L +    G  P ++
Sbjct: 587 GNYSCVASTELDVVESRAQLLVVGSPGPVPRLV 619



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 46/190 (24%), Positives = 81/190 (42%), Gaps = 14/190 (7%)

Query: 733 SETSVYVTWIPRANGGSPITAFKVEY--KRMRTSNWLVAAEDIPPSKLSVEVRSLEPGST 790
           +++ V V+W P  +  +PI  + +E+  K M    W    + +P ++ S  ++ L P   
Sbjct: 627 TQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGK-VPGNQTSTTLK-LSPYVH 684

Query: 791 YKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYI 850
           Y FRV AIN YG    S  S   + V  P    + P   P     E    T +++ W  +
Sbjct: 685 YTFRVTAINKYGPGEPSPVS---ETVVTP---EAAPEKNPVDVKGEGNETTNMVITWKPL 738

Query: 851 PSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEG 910
              + N P   + + +RP        ++  +V  S  + ++ +      Y+IK+Q  N  
Sbjct: 739 RWMDWNAPQVQYRVQWRP--QGTRGPWQEQIV--SDPFLVVSNTSTFVPYEIKVQAVNSQ 794

Query: 911 GESEFSNVMI 920
           G+     V I
Sbjct: 795 GKGPEPQVTI 804


>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
           sapiens]
          Length = 1257

 Score =  144 bits (364), Expect = 4e-34
 Identities = 201/905 (22%), Positives = 332/905 (36%), Gaps = 151/905 (16%)

Query: 78  HQGTLTILSLNSSLL----GYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEE 133
           H G+ TI   NS+      G Y+C A+N +G  +S    +       +   T   +  EE
Sbjct: 91  HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 150

Query: 134 KSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLIL-PSGNLQILNVSLEDKGS-YKC 191
             +  + C  P S     + Y +  K L    +  + +  +GNL   NV   D  S Y C
Sbjct: 151 GESVVLPCNPPPSAEPLRI-YWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 209

Query: 192 AAYNPVTHQL-KVEPIGRKLLVSRPSSD-DVHILHPTHSQA-LAVLSRSPVTLECVVSGV 248
            A+ P T  + + EPI  ++  +    D    +L PT+S + L  L   P+ LEC+  G 
Sbjct: 210 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 269

Query: 249 PAPQVYWLK-DGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVN 307
           P P + WL+  G   A    ++     L    V   D G Y C+A N  G  ++  Y+  
Sbjct: 270 PTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTV 329

Query: 308 VLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSA---RHLTAGNG 364
                 + K  Q  +   G T    C V G P P  TW  N  P+   A   ++      
Sbjct: 330 EAAPYWLHKP-QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGA 388

Query: 365 LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVA-DGDFVT 423
           L +S V   D  + QC A N  G + +   + +         I+TA     +A  G    
Sbjct: 389 LILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQ---LPAKILTADNQTYMAVQGSTAY 445

Query: 424 LSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGAS 483
           L C A G PVP ++W D  G      + VL+ +                 +F  +     
Sbjct: 446 LLCKAFGAPVPSVQWLDEDG------TTVLQDER----------------FFPYAN---G 480

Query: 484 SLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVV--------PFET-NTKAETVTLPDA 534
           +L I+ +     G+Y C AAN+       A+L V         P  T   K   VT    
Sbjct: 481 TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQ 540

Query: 535 AQNDDRSK---------RDGSETGLLSSFPVK-----VHP-----------------SAV 563
           A  D   +         RD  E G    + ++     +H                    V
Sbjct: 541 ASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVV 600

Query: 564 ESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVG 623
           ES  +    G   P   ++LS     T     + W   +D   PI  Y +++   +D   
Sbjct: 601 ESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEF---EDKEM 657

Query: 624 MLGSWHTV-RVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSK 682
               W+++ +VPG++    L +L P   Y   + A +  G G+P+ ++      + A  K
Sbjct: 658 APEKWYSLGKVPGNQTSTTL-KLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEK 716

Query: 683 NTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWI 742
           N             PV  +   N                             T++ +TW 
Sbjct: 717 N-------------PVDVKGEGN---------------------------ETTNMVITWK 736

Query: 743 PR--ANGGSPITAFKVEYKRMRTSN-WLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAIN 799
           P    +  +P   ++V+++   T   W    E I      V V +      Y+ +V A+N
Sbjct: 737 PLRWMDWNAPQVQYRVQWRPQGTRGPW---QEQIVSDPFLV-VSNTSTFVPYEIKVQAVN 792

Query: 800 HYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPI 859
             G+        P   +G+       P   P +   E ++ + +++KW  +  +     +
Sbjct: 793 SQGK-----GPEPQVTIGYSG--EDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHL 845

Query: 860 QGFYIYYRPTDSDNDSDYK-----RDVVEGSKQWHMIGHLQPETSYDIKMQCFN---EGG 911
           +G+ + Y    S      +       VV  +    ++  L+P +SY +++Q FN    G 
Sbjct: 846 RGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGP 905

Query: 912 ESEFS 916
            SEF+
Sbjct: 906 ASEFT 910



 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 102/393 (25%), Positives = 159/393 (40%), Gaps = 27/393 (6%)

Query: 27  LAPYFTSEPLSAVQKLGGPVVLHCSAQPVTT-RISWLHNGKTLDGNLEHVKIHQGTLTIL 85
           L P  +S  L A+Q  G P+VL C A+   T  I WL     +  +    + H  TL +L
Sbjct: 243 LFPTNSSSHLVALQ--GQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLL 300

Query: 86  SLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPE 145
            +     G Y+CLA NS+G+          A          H+    E +   + C+V +
Sbjct: 301 KVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETAR--LDCQV-Q 357

Query: 146 SNPKAEVRYKIRGKWLEH-STENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVE 204
             P+ EV ++I G  +E  + +    +  G L + NV   D    +C A N   H L + 
Sbjct: 358 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARN--RHGLLLA 415

Query: 205 PIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWL-KDGQDIA 263
                 +V  P+      +    +Q    +  S   L C   G P P V WL +DG  + 
Sbjct: 416 N-AYIYVVQLPAK-----ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL 469

Query: 264 PGSN-WRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVN--VLEHASISKGLQD 320
                +      L    +   D+G Y C+A N   D   VT M N  V +   I++G + 
Sbjct: 470 QDERFFPYANGTLGIRDLQANDTGRYFCLAAN---DQNNVTIMANLKVKDATQITQGPRS 526

Query: 321 QIVSLGATVHFTCDVHGNPA--PNCTW---FHNAQPIHPSARHLTAGNGLKISGVTVEDV 375
            I   G+ V FTC    +P+  P+ TW     + Q +  S ++      L I  +   D 
Sbjct: 527 TIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 586

Query: 376 GMYQCVADNGIGFMHSTGRLEIENDGGFKPVII 408
           G Y CVA   +  + S  +L +    G  P ++
Sbjct: 587 GNYSCVASTELDVVESRAQLLVVGSPGPVPRLV 619



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 46/190 (24%), Positives = 81/190 (42%), Gaps = 14/190 (7%)

Query: 733 SETSVYVTWIPRANGGSPITAFKVEY--KRMRTSNWLVAAEDIPPSKLSVEVRSLEPGST 790
           +++ V V+W P  +  +PI  + +E+  K M    W    + +P ++ S  ++ L P   
Sbjct: 627 TQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGK-VPGNQTSTTLK-LSPYVH 684

Query: 791 YKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYI 850
           Y FRV AIN YG    S  S   + V  P    + P   P     E    T +++ W  +
Sbjct: 685 YTFRVTAINKYGPGEPSPVS---ETVVTP---EAAPEKNPVDVKGEGNETTNMVITWKPL 738

Query: 851 PSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEG 910
              + N P   + + +RP        ++  +V  S  + ++ +      Y+IK+Q  N  
Sbjct: 739 RWMDWNAPQVQYRVQWRP--QGTRGPWQEQIV--SDPFLVVSNTSTFVPYEIKVQAVNSQ 794

Query: 911 GESEFSNVMI 920
           G+     V I
Sbjct: 795 GKGPEPQVTI 804


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  143 bits (360), Expect = 1e-33
 Identities = 139/516 (26%), Positives = 210/516 (40%), Gaps = 84/516 (16%)

Query: 26   DLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTT-RISWLHNGKTLDGNLEHVKI-HQGTLT 83
            ++ P     P S V  L    VL C A+ V T RI+W  +G  L GN     I   G L 
Sbjct: 3710 NVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLH 3769

Query: 84   ILSLNSSLLGYYQCLANNSIG--------------AIVSGPATVSVAVLGDFGSSTKHVI 129
            I S + +  G Y C+A N+ G              +I  GP  ++V V      + +  +
Sbjct: 3770 IQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV------NVQTTL 3823

Query: 130  TAEEKSAGFIGCRVPESNPKAEVRYKIRGKWL--EHSTENYLILPSGNLQILNVSLEDKG 187
              E               PK  + ++  G  L  + +  +Y +L SG+L I++ S++D  
Sbjct: 3824 ACEATGI-----------PKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTA 3872

Query: 188  SYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSG 247
            +Y+C   N      +   +  ++    PS  D     PT      V   +P  + C  SG
Sbjct: 3873 TYECTVTNGAGDDKRTVDLTVQV---PPSIAD----EPTD---FLVTKHAPAVITCTASG 3922

Query: 248  VPAPQVYWLKDGQDIAPGSNWRRLYSHLATD--SVDPADSGNYSCMAGNKSGDV-KYVTY 304
            VP P ++W K+G  + P  +  R+ S  A +  +     +G Y+C+A N +G   ++VT 
Sbjct: 3923 VPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVT- 3981

Query: 305  MVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARH--LTAG 362
             ++V E   I     +  V L   +   C+  G P+P  TW      ++ S R+  +   
Sbjct: 3982 -LHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPS 4040

Query: 363  NGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFV 422
             GL+IS    ED G Y CVA N  G      +L ++      PVI        +A    +
Sbjct: 4041 GGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQ----VPPVISPHLKEYVIAVDKPI 4096

Query: 423  TLSCNASGLPVPVIRWY-DSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAG 481
            TLSC A GLP P I W+ D   ++ S   +VL S                          
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIVESIRQRVLSS-------------------------- 4130

Query: 482  ASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMV 517
              SL I  V    AG Y C AAN  G++     L V
Sbjct: 4131 -GSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV 4165



 Score =  137 bits (345), Expect = 6e-32
 Identities = 157/513 (30%), Positives = 203/513 (39%), Gaps = 71/513 (13%)

Query: 29   PYFTSEPLSAVQKLGGPVVLHCSAQ--PVTTRISW--LHNGKTLDGNLEHVKIHQ---GT 81
            P F  EP     ++G  V L C  Q  P  T I W  L N            I Q   G 
Sbjct: 793  PVFIQEPADVSMEIGSNVTLPCYVQGYPEPT-IKWRRLDNMPIFSRPFSVSSISQLRTGA 851

Query: 82   LTILSLNSSLLGYYQCLANNSIGAIVSGPA---TVSVAVLGDFGSSTKHVITAEEKSAGF 138
            L IL+L +S  G Y C A N  G I S      T  VA L     S  +VI  ++ +   
Sbjct: 852  LFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLT--- 908

Query: 139  IGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVT 198
            + C +   NP  E R+ I+   +        +   G+L I  V L+D G Y C A N   
Sbjct: 909  LPCTLLAGNPIPERRW-IKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAG 967

Query: 199  HQLKVEPIGRKLLVSRPSSDDVHILHPT---HSQALAVLSRSPVTLECVVSGVPAPQVYW 255
               K             +S  VH+L PT     Q L+ +   PVTL C  SG P P V W
Sbjct: 968  TNNKT------------TSVVVHVL-PTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIW 1014

Query: 256  LKDGQDIAPGSNWRRLYSHLATDSVDPA--DSGNYSCMAGNKSGDVKYVTYMVNVLEHAS 313
             K G+ I+  S      +  +   V P   +SG Y C A N +G  K    +   +    
Sbjct: 1015 SKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRV 1074

Query: 314  I--SKGL-QDQIVSL----GATVHFTCDVHGNPAPNCTWFHNAQPIHP-SARHLTAGNG- 364
                +GL QD+ V +    G  V   C+V   P P  TW    Q I P S RH    +G 
Sbjct: 1075 FGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGS 1134

Query: 365  LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTL 424
            +KI+     D GMY CVA N  G +    +L +       P I   P   KV  G  V +
Sbjct: 1135 MKITETRTSDSGMYLCVATNIAGNVTQAVKLNVH----VPPKIQRGPKHLKVQVGQRVDI 1190

Query: 425  SCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASS 484
             CNA G P+PVI W  S G  T            +  +S P+G                +
Sbjct: 1191 PCNAQGTPLPVITW--SKGGST-------MLVDGEHHVSNPDG----------------T 1225

Query: 485  LHIQAVTQEHAGKYICEAANEHGTTQAEASLMV 517
            L I   T   AG Y C A N  GT + E +L V
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHV 1258



 Score =  136 bits (342), Expect = 1e-31
 Identities = 113/404 (27%), Positives = 171/404 (42%), Gaps = 35/404 (8%)

Query: 45   PVVLHCSAQPVTTR-ISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSI 103
            P+ L C A  +    I+W  +G+ +  ++    +  G+L I  +     G+Y C+A N  
Sbjct: 4095 PITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVA 4154

Query: 104  GAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEH 163
            G+  S  +T     +     ST+   T  E S   + C V +  P   + +K     L +
Sbjct: 4155 GS--SSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAINWKKDNVLLAN 4211

Query: 164  STENYLILPSGNLQILNVSLEDKGSYKCAAYNPV---THQLKVEPIGRKLLVSRPSSDDV 220
                Y   P G L + NV LED G Y C A N     TH + +                V
Sbjct: 4212 LLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLT---------------V 4256

Query: 221  HILHPTHSQALAVLSRSP---VTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLAT 277
            H+L PT ++    +S +    + L C  +G+P P++ W  +   I    +    +S L  
Sbjct: 4257 HVL-PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVI 4315

Query: 278  DSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKG--LQDQIVSLGATVHFTCDV 335
            + V   DSG Y C A N  G VK + ++   ++   + KG    + I  LG      C+V
Sbjct: 4316 ERVSKEDSGTYVCTAENSVGFVKAIGFVY--VKEPPVFKGDYPSNWIEPLGGNAILNCEV 4373

Query: 336  HGNPAPNCTWFHNAQPIHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHSTGR 394
             G+P P   W      I  S R    GNG L I G   ED G Y CVA N  G +  +  
Sbjct: 4374 KGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMS 4433

Query: 395  LEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRW 438
            L +++     P+I   PV   +  G  + L+C A+G P P I W
Sbjct: 4434 LTLQSP----PIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473



 Score =  132 bits (331), Expect = 3e-30
 Identities = 139/511 (27%), Positives = 201/511 (39%), Gaps = 58/511 (11%)

Query: 29   PYFTSEPLSAVQKLGGPVVLHCSAQPVTTR-ISWLHNGKTLD-GNLEHVKIHQGTLTILS 86
            P    +P      L  P++L C A    +  I+W   G  ++     H  +  G L I  
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISR 4047

Query: 87   LNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPES 146
                  G Y C+A N  G  + G   ++V V        K  + A +K    + C   + 
Sbjct: 4048 AVREDAGTYMCVAQNPAGTAL-GKIKLNVQVPPVISPHLKEYVIAVDKPIT-LSCEA-DG 4104

Query: 147  NPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPI 206
             P  ++ +   G+ +  S     +L SG+LQI  V   D G Y C A N           
Sbjct: 4105 LPPPDITWHKDGRAIVESIRQR-VLSSGSLQIAFVQPGDAGHYTCMAANVAGSS----ST 4159

Query: 207  GRKLLVSRPS---SDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIA 263
              KL V  P    S + H     +SQA+         L CV  G+P P + W KD   +A
Sbjct: 4160 STKLTVHVPPRIRSTEGHYTVNENSQAI---------LPCVADGIPTPAINWKKDNVLLA 4210

Query: 264  P--GSNWRRLYSHLATDSVDPADSGNYSCMAGNKSG-DVKYVTYMVNVLEHASISKGLQD 320
               G      Y  L  ++V   DSG Y+C+A N +G D   V+  V+VL   +   G  D
Sbjct: 4211 NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG--D 4268

Query: 321  QIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQC 380
              ++ G  +  +C   G P P  TW  N   I      +   + L I  V+ ED G Y C
Sbjct: 4269 VSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVC 4328

Query: 381  VADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYD 440
             A+N +GF+ + G + ++    FK      P +     G    L+C   G P P I+W  
Sbjct: 4329 TAENSVGFVKAIGFVYVKEPPVFKG---DYPSNWIEPLGGNAILNCEVKGDPTPTIQW-- 4383

Query: 441  SHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYIC 500
                            +RK       G+++E +   + Q G  SL I     E AG Y C
Sbjct: 4384 ----------------NRK-------GVDIE-ISHRIRQLGNGSLAIYGTVNEDAGDYTC 4419

Query: 501  EAANEHGTTQAEASLMV--VPFETNTKAETV 529
             A NE G  +   SL +   P  T    ETV
Sbjct: 4420 VATNEAGVVERSMSLTLQSPPIITLEPVETV 4450



 Score =  122 bits (306), Expect = 2e-27
 Identities = 131/488 (26%), Positives = 196/488 (40%), Gaps = 58/488 (11%)

Query: 41   KLGGPVVLHCSAQPV-TTRISWLHNGKTLDGNLEHVKIHQG--TLTILSLNSSLLGYYQC 97
            K+   + L C A  + +  +SW  +G+ L  + +HV I     TL I     S  G Y C
Sbjct: 2687 KVNNTLTLECEAYAIPSASLSWYKDGQPLKSD-DHVNIAANGHTLQIKEAQISDTGRYTC 2745

Query: 98   LANNSIGAI-----VSGPATVSVAVLGDFGSSTKHVITAEEKSAGF-----IGCRVPESN 147
            +A+N  G       V+     S   L + G+        E K         + C    + 
Sbjct: 2746 VASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAP 2805

Query: 148  PKAEVRYKIRGKWLEHSTENYLILPSGN-LQILNVSLEDKGSYKCAAYNPVTHQLKVEPI 206
            P     YK  G  L  S++  LILP G  LQI    +ED G Y C A N          +
Sbjct: 2806 PPTLTWYK-DGHPLT-SSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDV 2863

Query: 207  GRKLL--VSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAP 264
             R L+  + + ++ D+        + + VL      +EC+ SG PAP+  W KDGQ +  
Sbjct: 2864 -RVLVPPIIKGANSDL-------PEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLE 2915

Query: 265  GSNWRRLYSH--LATDSVDPADSGNYSCMAGNKSGDV-KYVTYMVNVLEHASISKGLQDQ 321
              + + L +   L   +    D G Y C+A N +G   KY    V+V   + I    ++ 
Sbjct: 2916 DDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV-PPSVIGPKSENL 2974

Query: 322  IVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHL--TAGNGLKISGVTVEDVGMYQ 379
             V +   +  TC+V G P P+ +W  N QPI  +   L    G  L+I    V D G Y 
Sbjct: 2975 TVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYT 3034

Query: 380  CVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWY 439
            C+A N  G       L +      K     +     V +G  V+L C ++ +P PVI WY
Sbjct: 3035 CIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWY 3094

Query: 440  DSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYI 499
             +  +IT                   E  ++E +      A    LHI+       G+Y+
Sbjct: 3095 KNGRMIT-------------------ESTHVEIL------ADGQMLHIKKAEVSDTGQYV 3129

Query: 500  CEAANEHG 507
            C A N  G
Sbjct: 3130 CRAINVAG 3137



 Score =  120 bits (300), Expect = 1e-26
 Identities = 142/589 (24%), Positives = 223/589 (37%), Gaps = 77/589 (13%)

Query: 45   PVVLHCSAQPVTT-RISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLL---GYYQCLAN 100
            PV L C A  +    I+WL + + ++    ++KI Q +  +L +  +LL   G Y C+A 
Sbjct: 1843 PVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI-QSSGRVLQIAKTLLEDAGRYTCVAT 1901

Query: 101  NSIGA--------IVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEV 152
            N+ G         +   P+      + +      + +  E K+AG         NP   +
Sbjct: 1902 NAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAG---------NPVPVI 1952

Query: 153  RYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLV 212
             +    + L  ST    +     + I +  + D G YKC A N          +   +  
Sbjct: 1953 TWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAP 2012

Query: 213  SRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLY 272
            S   S+++          +AV+  +PV LEC   G+PAP + WLKDG  ++  SN  ++ 
Sbjct: 2013 SISGSNNM----------VAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVL 2062

Query: 273  SH---LATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATV 329
            S    LA  S   +D+G Y+C+A N +G+ K     + V    +I    Q+  V +   V
Sbjct: 2063 SGGRILALTSAQISDTGRYTCVAVNAAGE-KQRDIDLRVYVPPNIMGEEQNVSVLISQAV 2121

Query: 330  HFTCDVHGNPAPNCTWFHNAQPI--HPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIG 387
               C     P P  TW  +  P+   P        + LKI    V+D G Y C A N  G
Sbjct: 2122 ELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG 2181

Query: 388  FMHSTGRLEI---ENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGL 444
                   + I    N GG   +         V +G+ ++L C +SG+P P + W      
Sbjct: 2182 KTEKNYNVNIWVPPNIGGSDEL-----TQLTVIEGNLISLLCESSGIPPPNLIW------ 2230

Query: 445  ITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAAN 504
                 S VL     + ++                 +G   L I    +  A  Y C A+N
Sbjct: 2231 -KKKGSPVLTDSMGRVRI----------------LSGGRQLQISIAEKSDAALYSCVASN 2273

Query: 505  EHGTTQAEASLMVV--PFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSA 562
              GT + E +L V   P  TN+ +    +        R K    E   +   P       
Sbjct: 2274 VAGTAKKEYNLQVYIRPTITNSGSHPTEIIVT-----RGKSISLECE-VQGIPPPTVTWM 2327

Query: 563  VESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAY 611
             +  P   A G+ + D   IL     H  DT   V  A    G+    Y
Sbjct: 2328 KDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKY 2376



 Score =  118 bits (295), Expect = 4e-26
 Identities = 131/530 (24%), Positives = 208/530 (39%), Gaps = 98/530 (18%)

Query: 34   EPLSAVQKLGGPVVLHCSAQPVTTRISWLHNGKTLDGNLEHVKIHQG--TLTILSLNSSL 91
            E +S V+K    +    S  P+ + I+W  +G  +  +   V+I  G   L ++      
Sbjct: 2394 ENISVVEKNSVSLTCEASGIPLPS-ITWFKDGWPVSLS-NSVRILSGGRMLRLMQTTMED 2451

Query: 92   LGYYQCLANNSIGA---IVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNP 148
             G Y C+  N+ G    I      V   ++G+   +T   +  +EK +  + C V   NP
Sbjct: 2452 AGQYTCVVRNAAGEERKIFGLSVLVPPHIVGE---NTLEDVKVKEKQSVTLTCEVT-GNP 2507

Query: 149  KAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGR 208
              E+ +   G+ L+    +++I     LQI NV +   G Y C A +P  H  K      
Sbjct: 2508 VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGH--KSRSFSL 2565

Query: 209  KLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNW 268
             + VS   +    +    + + + V+  SP +L C     P   + W KDG  +    N 
Sbjct: 2566 NVFVSPTIAG---VGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNI 2622

Query: 269  RRLYSHLATDSVDPAD--SGNYSCMAGNKSGD-VKYVTYMVNVLEHASISKG-------- 317
            R L        ++  +  +G YSC+A N++G+ +K+  Y V V     I+KG        
Sbjct: 2623 RILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKH--YEVKVYIPPIINKGDLWGPGLS 2680

Query: 318  LQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNG--LKISGVTVEDV 375
             ++  + +  T+   C+ +  P+ + +W+ + QP+        A NG  L+I    + D 
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDT 2740

Query: 376  GMYQCVADN-----------------------GIGFMHSTGRLEIENDGGFKPVIITAPV 412
            G Y CVA N                        IG M  TGR     +G  K VII  P+
Sbjct: 2741 GRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGR-----NGEAKDVIINNPI 2795

Query: 413  SAKVADGDFVTLSCNASGLPVPVIRWY-DSHGLITSHPSQVLRSKSRKSQLSRPEGLNLE 471
            S          L C  +  P P + WY D H L +S                        
Sbjct: 2796 S----------LYCETNAAPPPTLTWYKDGHPLTSSDK---------------------- 2823

Query: 472  PVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHG--TTQAEASLMVVP 519
                VL   G   L I     E AG+Y C A NE G  + Q +  ++V P
Sbjct: 2824 ----VLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869



 Score =  115 bits (287), Expect = 3e-25
 Identities = 129/510 (25%), Positives = 199/510 (39%), Gaps = 51/510 (10%)

Query: 22   SVSSDLAPYFTSEPLSAVQKLGGPVVLHCS---AQPVTTRISWLHNGKTLDGNLEHVKIH 78
            +V+  +AP     P  A    G  + L C+     P+  R  W+ N   L  N       
Sbjct: 883  TVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPER-RWIKNSAMLLQNPYITVRS 941

Query: 79   QGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGF 138
             G+L I  +     G Y C+A+N  G   +   +V V VL       + +++  E     
Sbjct: 942  DGSLHIERVQLQDGGEYTCVASNVAGTN-NKTTSVVVHVLPTIQHG-QQILSTIEGIPVT 999

Query: 139  IGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVT 198
            + C+    NPK  V +  +G+ +  S+  +     G+L +++   E+ G Y C A N   
Sbjct: 1000 LPCKA-SGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAG 1058

Query: 199  H-----QLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQV 253
            +     QL V    R     R  S D  +        ++VL+   VTL C V  +P P +
Sbjct: 1059 YAKRKVQLTVYVRPRVFGDQRGLSQDKPV-------EISVLAGEEVTLPCEVKSLPPPII 1111

Query: 254  YWLKDGQDIAPGSNWRRLY--SHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEH 311
             W K+ Q I+P S          +       +DSG Y C+A N +G+V     + NV   
Sbjct: 1112 TWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKL-NVHVP 1170

Query: 312  ASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAG--NGLKISG 369
              I +G +   V +G  V   C+  G P P  TW      +     H  +     L I  
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQ 1230

Query: 370  VTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVI--ITAPVSAKVADGDFVTLSCN 427
             T  D G+Y CVA N  G   +   L ++     + +          +VA+   +   C 
Sbjct: 1231 ATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVAN-QRIEFPCP 1289

Query: 428  ASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHI 487
            A G P P I+W  +   +T                        EP   +L     + L I
Sbjct: 1290 AKGTPKPTIKWLHNGRELTGR----------------------EPGISILEDG--TLLVI 1325

Query: 488  QAVTQEHAGKYICEAANEHGTTQAEASLMV 517
             +VT    G+YIC A NE GTT+ + +L V
Sbjct: 1326 ASVTPYDNGEYICVAVNEAGTTERKYNLKV 1355



 Score =  115 bits (287), Expect = 3e-25
 Identities = 131/510 (25%), Positives = 195/510 (38%), Gaps = 97/510 (19%)

Query: 42   LGGPVVLHCSA--QPVTTRISWLHNGKTLDGNLEHVKIHQGTLT-ILSLNSSLLGYYQCL 98
            +  PV L C A   PV   I+W  + + L G+     +++G +  I S   S  G Y+C+
Sbjct: 1934 VSNPVQLECKAAGNPVPV-ITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCV 1992

Query: 99   ANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRG 158
            A NS GA               F S   HV  +   S   +   V   N    +  + RG
Sbjct: 1993 AINSAGATEL------------FYSLQVHVAPSISGSNNMVAVVV---NNPVRLECEARG 2037

Query: 159  ------KWLEH-----STENYLILPSGN--LQILNVSLEDKGSYKCAAYNPVTHQLKVEP 205
                   WL+      S  N L + SG   L + +  + D G Y C A N    + +   
Sbjct: 2038 IPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQR--- 2094

Query: 206  IGRKLLVSRPSSDDVHILHPTH----SQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQD 261
                         D+ +  P +     Q ++VL    V L C    +P P + WLKDG  
Sbjct: 2095 -----------DIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHP 2143

Query: 262  IA--PGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQ 319
            +   PG +     S L  +     D+G Y+C A N +G  +   Y VN+    +I  G  
Sbjct: 2144 LLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEK-NYNVNIWVPPNI--GGS 2200

Query: 320  DQIVSL----GATVHFTCDVHGNPAPNCTWFHNAQPIHPSA----RHLTAGNGLKISGVT 371
            D++  L    G  +   C+  G P PN  W     P+   +    R L+ G  L+IS   
Sbjct: 2201 DELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE 2260

Query: 372  VEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITA---PVSAKVADGDFVTLSCNA 428
              D  +Y CVA N  G    T + E       +P I  +   P    V  G  ++L C  
Sbjct: 2261 KSDAALYSCVASNVAG----TAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV 2316

Query: 429  SGLPVPVIRWY-DSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHI 487
             G+P P + W  D H LI +   ++L            EG  L+            ++H+
Sbjct: 2317 QGIPPPTVTWMKDGHPLIKAKGVEIL-----------DEGHILQ----------LKNIHV 2355

Query: 488  QAVTQEHAGKYICEAANEHGTTQAEASLMV 517
                    G+Y+C A N  G T  +  L V
Sbjct: 2356 S-----DTGRYVCVAVNVAGMTDKKYDLSV 2380



 Score =  114 bits (286), Expect = 5e-25
 Identities = 137/511 (26%), Positives = 211/511 (41%), Gaps = 83/511 (16%)

Query: 58   RISWLHNGKTLDGNLEHVKIHQGT-LTILSLNSSLLGYYQCLANNSIGAI---------- 106
            R SW  +G+ L  +  H  +  G  L IL+   + +G Y C+A N+ G+           
Sbjct: 2903 RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV 2962

Query: 107  ---VSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEH 163
               V GP + ++ V+        + I+   + +GF         P  ++ +    + ++ 
Sbjct: 2963 PPSVIGPKSENLTVV------VNNFISLTCEVSGF---------PPPDLSWLKNEQPIKL 3007

Query: 164  STENYLILPSGN-LQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHI 222
            +T N LI+P G  LQI+   + D G Y C A N      K       L V  P S   H 
Sbjct: 3008 NT-NTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKF----SLTVYVPPSIKDH- 3061

Query: 223  LHPTHSQALAVLS---RSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSH--LAT 277
                 S++L+V++    + V+LEC  + VP P + W K+G+ I   ++   L     L  
Sbjct: 3062 ----DSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHI 3117

Query: 278  DSVDPADSGNYSCMAGNKSG-DVKYVTYMVNVLEHASISKGLQDQIV-SLGATVHFTCDV 335
               + +D+G Y C A N +G D K   + +NV    SI    ++ IV ++   V  TCD 
Sbjct: 3118 KKAEVSDTGQYVCRAINVAGRDDK--NFHLNVYVPPSIEGPEREVIVETISNPVTLTCDA 3175

Query: 336  HGNPAPNCTWFHNAQPIHPS----ARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHS 391
             G P P   W  N + I  S     R L+ G+ L+I+     D G Y C+A N  G    
Sbjct: 3176 TGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQK 3235

Query: 392  TGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQ 451
               L I+         I + VS  +  G+ V L CNA+G+P P+I+W      I S  ++
Sbjct: 3236 YYFLSIQVPPSVAGAEIPSDVSVLL--GENVELVCNANGIPTPLIQWLKDGKPIASGETE 3293

Query: 452  VLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQA 511
             +R                         A  S+L+I        GKY C A N  G    
Sbjct: 3294 RIR-----------------------VSANGSTLNIYGALTSDTGKYTCVATNPAGEEDR 3330

Query: 512  --EASLMVVPFETNTKAET---VTLPDAAQN 537
                ++ V P     K E    +TL D + N
Sbjct: 3331 IFNLNVYVTPTIRGNKDEAEKLMTLVDTSIN 3361



 Score =  114 bits (284), Expect = 8e-25
 Identities = 129/494 (26%), Positives = 202/494 (40%), Gaps = 69/494 (13%)

Query: 42   LGGPVVLHCSAQPVTT-RISWLHNGKTLDGNLEHVKIHQG-TLTILSLNSSLLGYYQCLA 99
            +  P+ L C A  +   +++W+ +G+ L    +   +  G  L I +      G Y CLA
Sbjct: 3542 VNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLA 3601

Query: 100  NNSIGA-----IVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRY 154
            ++  G      +V      ++A     G+     IT        + C+  ++ P   + +
Sbjct: 3602 SSPAGDDDKEYLVRVHVPPNIA-----GTDEPRDITVLRNRQVTLECK-SDAVPPPVITW 3655

Query: 155  KIRGKWLEHSTENYLILPSGN-LQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVS 213
               G+ L+ +T    IL  G  LQI N  L D  +Y C A N +  +   E I   L V+
Sbjct: 3656 LRNGERLQ-ATPRVRILSGGRYLQINNADLGDTANYTCVASN-IAGKTTREFI---LTVN 3710

Query: 214  RPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYS 273
             P +           Q+L +L      LEC+  GVP P++ W KDG  +A G++ R  YS
Sbjct: 3711 VPPNIK------GGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLA-GNHAR--YS 3761

Query: 274  HLAT-----DSVDPADSGNYSCMAGNKSG-DVKYVTYMVNVLEHASISKGLQDQIVSLGA 327
             L        S    D+G Y CMA N +G D + +   V+V    SI+ G  +  V +  
Sbjct: 3762 ILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHV--PPSIAPGPTNMTVIVNV 3819

Query: 328  TVHFTCDVHGNPAPNCTWFHNAQPIH----PSARHLTAGNGLKISGVTVEDVGMYQCVAD 383
                 C+  G P P+  W  N   ++     ++  L +   L I   +V+D   Y+C   
Sbjct: 3820 QTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVT 3879

Query: 384  NGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHG 443
            NG G    T  L ++      P I   P    V       ++C ASG+P P I W     
Sbjct: 3880 NGAGDDKRTVDLTVQ----VPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHW----- 3930

Query: 444  LITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAA 503
                       +K+    L R +G      Y +LS   + ++ I A    HAG+Y C A 
Sbjct: 3931 -----------TKNGIRLLPRGDG------YRILS---SGAIEILATQLNHAGRYTCVAR 3970

Query: 504  NEHGTTQAEASLMV 517
            N  G+     +L V
Sbjct: 3971 NAAGSAHRHVTLHV 3984



 Score =  113 bits (283), Expect = 1e-24
 Identities = 127/506 (25%), Positives = 194/506 (38%), Gaps = 72/506 (14%)

Query: 42   LGGPVVLHCSAQ---PVTTRISWLHNGKTLDGNLEHVKIHQG--TLTILSLNSSLLGYYQ 96
            L  P  L C A    P T  I+W  +G  L+ N  +++I  G  TL IL+      G Y 
Sbjct: 2589 LNSPTSLVCEAYSYPPAT--ITWFKDGTPLESN-RNIRILPGGRTLQILNAQEDNAGRYS 2645

Query: 97   CLANNSIGAIVSG-------PATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPK 149
            C+A N  G ++         P  ++   L   G S K V   +  +   + C    + P 
Sbjct: 2646 CVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEV-KIKVNNTLTLECEA-YAIPS 2703

Query: 150  AEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQ-------LK 202
            A + +   G+ L+      +      LQI    + D G Y C A N            ++
Sbjct: 2704 ASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQ 2763

Query: 203  VEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDI 262
            V P  +KL       D        + +A  V+  +P++L C  +  P P + W KDG  +
Sbjct: 2764 VPPSFQKLWEIGNMLDTGR-----NGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818

Query: 263  APGSNWRRLYSH--LATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQD 320
                    L     L        D+G Y+C+A N++G+   + Y V VL    I KG   
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGE-DSLQYDVRVLV-PPIIKGANS 2876

Query: 321  QI-----VSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNG--LKISGVTVE 373
             +     V +  +    C   G+PAP  +W  + QP+     H    NG  L+I    + 
Sbjct: 2877 DLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT 2936

Query: 374  DVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAK--VADGDFVTLSCNASGL 431
            D+G Y CVA+N  G       L +       P  +  P S    V   +F++L+C  SG 
Sbjct: 2937 DIGRYVCVAENTAGSAKKYFNLNVH-----VPPSVIGPKSENLTVVVNNFISLTCEVSGF 2991

Query: 432  PVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVT 491
            P P + W  +                      +P  LN       L   G  +L I    
Sbjct: 2992 PPPDLSWLKN---------------------EQPIKLNTN----TLIVPGGRTLQIIRAK 3026

Query: 492  QEHAGKYICEAANEHGTTQAEASLMV 517
                G+Y C A N+ G ++ + SL V
Sbjct: 3027 VSDGGEYTCIAINQAGESKKKFSLTV 3052



 Score =  112 bits (280), Expect = 2e-24
 Identities = 124/490 (25%), Positives = 183/490 (37%), Gaps = 64/490 (13%)

Query: 41   KLGGPVVLHCSAQPVTTR-ISWLHNGKTL--DGNLEHVKIHQGTLTILSLNSSLLGYYQC 97
            ++G  V + C+AQ      I+W   G T+  DG   HV    GTL+I     S  G Y C
Sbjct: 1183 QVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGE-HHVSNPDGTLSIDQATPSDAGIYTC 1241

Query: 98   LANNSIGAI-------VSGPATVSVAVLGDFGSSTKHVITAEEKSAGF-IGCRVP-ESNP 148
            +A N  G         V  P TV             +  T +E+ A   I    P +  P
Sbjct: 1242 VATNIAGTDETEITLHVQEPPTVE-------DLEPPYNTTFQERVANQRIEFPCPAKGTP 1294

Query: 149  KAEVRYKIRGKWLEHSTENYLILPSGNLQIL-NVSLEDKGSYKCAAYNPV-THQLKVEPI 206
            K  +++   G+ L        IL  G L ++ +V+  D G Y C A N   T + K    
Sbjct: 1295 KPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYN-- 1352

Query: 207  GRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGS 266
              K+ V     D   + +      ++VL      L C V G P+P + W KD   +   S
Sbjct: 1353 -LKVHVPPVIKDKEQVTN------VSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESS 1405

Query: 267  NWRRLYSH--LATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQI-V 323
              + + +   L      P D+G YSC A N +G  +    +  ++    I     +++ V
Sbjct: 1406 TIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSV 1465

Query: 324  SLGATVHFTCDVHGNPAPNCTWFHNAQPI---HPSARHLTAGNGLKISGVTVEDVGMYQC 380
             L   V   C V G P P+  WF + +P+    P+   L  G  L +      D G YQC
Sbjct: 1466 VLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQC 1525

Query: 381  VADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYD 440
               N  G      +L I      K   +T  +S  +     + L C   GLP+P I WY 
Sbjct: 1526 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLI--NSLIKLECETRGLPMPAITWYK 1583

Query: 441  SHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYIC 500
                      Q + S S+   + +                    LHI       +  Y C
Sbjct: 1584 D--------GQPIMSSSQALYIDK-----------------GQYLHIPRAQVSDSATYTC 1618

Query: 501  EAANEHGTTQ 510
              AN  GT +
Sbjct: 1619 HVANVAGTAE 1628



 Score =  111 bits (278), Expect = 4e-24
 Identities = 115/467 (24%), Positives = 182/467 (38%), Gaps = 46/467 (9%)

Query: 58   RISWLHNGKTLDGNLEHVKIHQG--TLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSV 115
            +I+WL NG  L  +  H+++      + I+    S +  Y C+A+N  G           
Sbjct: 3373 QINWLKNGLPLPLS-SHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVF 3431

Query: 116  AVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGN 175
            A      S     IT  + S+  + C + +  P   + +   G+ L       +      
Sbjct: 3432 APPNMDNSMGTEEITVLKGSSTSMAC-ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMV 3490

Query: 176  LQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLS 235
            LQ+L    ED G Y C A N      K   +  K+L      +  HI      + ++V+ 
Sbjct: 3491 LQLLKAETEDSGKYTCIASNEAGEVSKHFIL--KVL------EPPHINGSEEHEEISVIV 3542

Query: 236  RSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSH--LATDSVDPADSGNYSCMAG 293
             +P+ L C+ SG+PAP++ W+KDG+ +      + L     L   +    D+G Y+C+A 
Sbjct: 3543 NNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLAS 3602

Query: 294  NKSG-DVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPI 352
            + +G D K     V+V  + + +   +D  V     V   C     P P  TW  N + +
Sbjct: 3603 SPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERL 3662

Query: 353  H--PSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITA 410
               P  R L+ G  L+I+   + D   Y CVA N  G    T R E        P I   
Sbjct: 3663 QATPRVRILSGGRYLQINNADLGDTANYTCVASNIAG---KTTR-EFILTVNVPPNIKGG 3718

Query: 411  PVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNL 470
            P S  +       L C A G+P P I W     ++  + ++                   
Sbjct: 3719 PQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHAR------------------- 3759

Query: 471  EPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMV 517
               Y +L       LHIQ+      G+Y+C A N  GT +    L V
Sbjct: 3760 ---YSILEN---GFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV 3800



 Score =  110 bits (275), Expect = 8e-24
 Identities = 130/528 (24%), Positives = 205/528 (38%), Gaps = 70/528 (13%)

Query: 14   VTLTILCSSVSSDLAPYF--TSEPLSAVQKLGGPVVLHCSAQPVTTRISWLHNGKTLDGN 71
            +TL +       DL P +  T +   A Q++  P     + +P    I WLHNG+ L G 
Sbjct: 1254 ITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPT---IKWLHNGRELTGR 1310

Query: 72   LEHVKI-HQGTLTIL-SLNSSLLGYYQCLANNSIGAIVSGPATVSV---AVLGDFGSSTK 126
               + I   GTL ++ S+     G Y C+A N  G        + V    V+ D    T 
Sbjct: 1311 EPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT-TERKYNLKVHVPPVIKDKEQVTN 1369

Query: 127  HVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGN-LQILNVSLED 185
              +   + +  F  C V  +     + YK   +  E ST     + +G  L++   + ED
Sbjct: 1370 VSVLLNQLTNLF--CEVEGTPSPIIMWYKDNVQVTESSTIQ--TVNNGKILKLFRATPED 1425

Query: 186  KGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVV 245
             G Y C A N      K   I     V  P +    I+       ++V+    V LEC V
Sbjct: 1426 AGRYSCKAINIAGTSQKYFNID----VLVPPT----IIGTNFPNEVSVVLNRDVALECQV 1477

Query: 246  SGVPAPQVYWLKDGQDIAPGSNWRRLYSH---LATDSVDPADSGNYSCMAGNKSG----D 298
             G P P ++W KDG+ +  G     L      L   +    D G Y C   N +G    D
Sbjct: 1478 KGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKD 1537

Query: 299  VKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPS--A 356
            +K   Y+   ++  +++    D  V + + +   C+  G P P  TW+ + QPI  S  A
Sbjct: 1538 IKLTIYIPPSIKGGNVT---TDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQA 1594

Query: 357  RHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVI---ITAPVS 413
             ++  G  L I    V D   Y C   N  G    T       D    P+I   +  P++
Sbjct: 1595 LYIDKGQYLHIPRAQVSDSATYTCHVANVAG----TAEKSFHVDVYVPPMIEGNLATPLN 1650

Query: 414  AKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPV 473
             +V     +TL C A+G P P++ W                           +G+ ++  
Sbjct: 1651 KQVVIAHSLTLECKAAGNPSPILTWL-------------------------KDGVPVKAN 1685

Query: 474  YFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQA--EASLMVVP 519
              +  +AG   L I +  +   G+YIC A +  G  +   E  ++V P
Sbjct: 1686 DNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPP 1733



 Score =  110 bits (274), Expect = 1e-23
 Identities = 122/493 (24%), Positives = 192/493 (38%), Gaps = 78/493 (15%)

Query: 43   GGPVVLHCSAQPVTT-RISWLHNGK-TLDGNLEHVKIHQG--TLTILSLNSSLLGYYQCL 98
            G  + L C +  +    + W   G   L  ++  V+I  G   L I     S    Y C+
Sbjct: 2211 GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCV 2270

Query: 99   ANNSIGAIVSGPATVSVAV---LGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYK 155
            A+N  G        + V +   + + GS    +I    KS   + C V    P      K
Sbjct: 2271 ASNVAGT-AKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSIS-LECEVQGIPPPTVTWMK 2328

Query: 156  -----IRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKL 210
                 I+ K +E   E ++      LQ+ N+ + D G Y C A N      K   +    
Sbjct: 2329 DGHPLIKAKGVEILDEGHI------LQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLS--- 2379

Query: 211  LVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRR 270
             V  P S   +   P +   ++V+ ++ V+L C  SG+P P + W KDG  ++  ++ R 
Sbjct: 2380 -VHAPPSIIGNHRSPEN---ISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRI 2435

Query: 271  LYSH--LATDSVDPADSGNYSCMAGNKSGDVKYVTYM-VNVLEHASISKGLQDQIVSLGA 327
            L     L        D+G Y+C+  N +G+ + +  + V V  H      L+D  V    
Sbjct: 2436 LSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQ 2495

Query: 328  TVHFTCDVHGNPAPNCTWFHNAQPIHPSARH--LTAGNGLKISGVTVEDVGMYQCVADNG 385
            +V  TC+V GNP P  TW  + QP+     H  ++ G  L+I+ V V   G Y C+A + 
Sbjct: 2496 SVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSP 2555

Query: 386  IGFMHSTGRLE---------IENDGGFK--PVIITAPVSAKVADGDFVTLSCNASGLPVP 434
             G    +  L          + +DG  +   VI+ +P S          L C A   P  
Sbjct: 2556 AGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS----------LVCEAYSYPPA 2605

Query: 435  VIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEH 494
             I W+                          +G  LE    +    G  +L I    +++
Sbjct: 2606 TITWF-------------------------KDGTPLESNRNIRILPGGRTLQILNAQEDN 2640

Query: 495  AGKYICEAANEHG 507
            AG+Y C A NE G
Sbjct: 2641 AGRYSCVATNEAG 2653



 Score =  108 bits (271), Expect = 2e-23
 Identities = 122/497 (24%), Positives = 193/497 (38%), Gaps = 58/497 (11%)

Query: 35   PLSAVQKLGGPVVLHCSAQPVTTRI-SWLHNGKTLDGNLEHVKIHQG--TLTILSLNSSL 91
            PL+    +   + L C A    + I +WL +G  +  N ++++I  G   L I+S     
Sbjct: 1648 PLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAN-DNIRIEAGGKKLEIMSAQEID 1706

Query: 92   LGYYQCLANNSIGAI-VSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKA 150
             G Y C+A +  G   +     V V    + G  T + I         + C V  S P  
Sbjct: 1707 RGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLE-LDCHVTGSPPPT 1765

Query: 151  EVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKL 210
             +  K  G+ ++      ++L    L I    + + G Y+C A N      K   +    
Sbjct: 1766 IMWLK-DGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEV---- 1820

Query: 211  LVSRPSSDDVHILHPTHSQALA---VLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSN 267
                     VH+     S  L+   V+   PV L+C+ +G+P P + WLKD Q +     
Sbjct: 1821 --------TVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQG 1872

Query: 268  WRRLYSH---LATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKG--LQDQI 322
              ++ S    L        D+G Y+C+A N +G+ +     ++V E  S+     + ++ 
Sbjct: 1873 NLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQ-HIQLHVHEPPSLEDAGKMLNET 1931

Query: 323  VSLGATVHFTCDVHGNPAPNCTWFHNAQPI--HPSARHLTAGNGLKISGVTVEDVGMYQC 380
            V +   V   C   GNP P  TW+ + + +    S   L  G  + I    + D G+Y+C
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKC 1991

Query: 381  VADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYD 440
            VA N  G       L++       P I  +     V   + V L C A G+P P + W  
Sbjct: 1992 VAINSAGATELFYSLQVH----VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTW-- 2045

Query: 441  SHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYIC 500
                        L+  S  S  S   GL       VLS  G   L + +      G+Y C
Sbjct: 2046 ------------LKDGSPVSSFS--NGLQ------VLS--GGRILALTSAQISDTGRYTC 2083

Query: 501  EAANEHGTTQAEASLMV 517
             A N  G  Q +  L V
Sbjct: 2084 VAVNAAGEKQRDIDLRV 2100



 Score =  106 bits (265), Expect = 1e-22
 Identities = 133/502 (26%), Positives = 208/502 (41%), Gaps = 56/502 (11%)

Query: 33   SEPLSAVQ-KLGGPVVLHCSAQPVTTR-ISWLHNGKTLDGNLEHVKIHQG--TLTILSLN 88
            SE LS V  + G  V L C +  V    I+W  NG+ +  +  HV+I      L I    
Sbjct: 3063 SESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITEST-HVEILADGQMLHIKKAE 3121

Query: 89   SSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNP 148
             S  G Y C A N  G        ++V V        + VI     +   + C      P
Sbjct: 3122 VSDTGQYVCRAINVAGRDDKN-FHLNVYVPPSIEGPEREVIVETISNPVTLTCDAT-GIP 3179

Query: 149  KAEVRYKIRGKWLEHSTENYLILPSGN--LQILNVSLEDKGSYKCAAYNPVTHQLKVEPI 206
               + +    K +E+S    + + SG   LQI      D G+Y C A N      K   +
Sbjct: 3180 PPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFL 3239

Query: 207  GRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGS 266
              ++    PS     I        ++VL    V L C  +G+P P + WLKDG+ IA G 
Sbjct: 3240 SIQV---PPSVAGAEI-----PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291

Query: 267  NWR-RLYSHLATDSVDPA---DSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQI 322
              R R+ ++ +T ++  A   D+G Y+C+A N +G+   + + +NV    +I +G +D+ 
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRI-FNLNVYVTPTI-RGNKDEA 3349

Query: 323  VSL----GATVHFTCDVHGNPAPNCTWFHNAQPIHPSA--RHLTAGNGLKISGVTVEDVG 376
              L      +++  C   G P P   W  N  P+  S+  R L AG  ++I    V DV 
Sbjct: 3350 EKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVA 3409

Query: 377  MYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVI 436
            +Y CVA N  G  +    L++         + T  ++  V  G   +++C   G P P +
Sbjct: 3410 VYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEIT--VLKGSSTSMACITDGTPAPSM 3467

Query: 437  RWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAG 496
             W              LR         +P GL+    +  +S  G     ++A T++ +G
Sbjct: 3468 AW--------------LRD-------GQPLGLD---AHLTVSTHGMVLQLLKAETED-SG 3502

Query: 497  KYICEAANEHGTTQAEASLMVV 518
            KY C A+NE G       L V+
Sbjct: 3503 KYTCIASNEAGEVSKHFILKVL 3524



 Score =  101 bits (252), Expect = 4e-21
 Identities = 119/478 (24%), Positives = 182/478 (38%), Gaps = 73/478 (15%)

Query: 59  ISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGA--------IVSGP 110
           +S++ NG TL  +    +     L I  +  S  G+Y+C+A +S G         +   P
Sbjct: 461 LSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPP 520

Query: 111 ATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLI 170
             + V           + +T        + C +  +     V Y +   W  +  +  L 
Sbjct: 521 PVIQVP----------NNVTVTPGERAVLTCLIISA-----VDYNLT--WQRNDRDVRLA 563

Query: 171 LPSGNLQILNVSLE-------DKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHIL 223
            P+    + N+SLE       D G Y C     V+ +         L V  P    V ++
Sbjct: 564 EPARIRTLANLSLELKSVKFNDAGEYHCM----VSSEGGSSAASVFLTVQEPPK--VTVM 617

Query: 224 HPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSH--LATDSVD 281
               S        S V++ C  +G P P++ W  +   I  GS+  R+ S   L   +  
Sbjct: 618 PKNQS----FTGGSEVSIMCSATGYPKPKIAWTVNDMFIV-GSHRYRMTSDGTLFIKNAA 672

Query: 282 PADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAP 341
           P D+G Y C+A N +G  K  + +   +E   +     + +V+LG      C   G P P
Sbjct: 673 PKDAGIYGCLASNSAGTDKQNSTL-RYIEAPKLMVVQSELLVALGDITVMECKTSGIPPP 731

Query: 342 NCTWFHNAQPIHPSARHLTAG--NGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIEN 399
              WF     + PS   +       LKI      D G Y CVA N  G   +TG++ +  
Sbjct: 732 QVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG--RATGKITL-- 787

Query: 400 DGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRK 459
           D G  PV I  P    +  G  VTL C   G P P I+W               R     
Sbjct: 788 DVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW---------------RRLDNM 832

Query: 460 SQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMV 517
              SRP  ++       +SQ    +L I  +     G YICEA N+ G  Q+E ++ V
Sbjct: 833 PIFSRPFSVS------SISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV 884



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 102/389 (26%), Positives = 153/389 (39%), Gaps = 53/389 (13%)

Query: 141  CRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGN-LQILNVSLEDKGSYKCAAYNPVTH 199
            C+V +  P  ++ +   GK L     N  +L  G  L + N    DKG Y+C   N    
Sbjct: 1475 CQV-KGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGK 1533

Query: 200  QLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDG 259
            Q K      KL +  P S    I     +  ++VL  S + LEC   G+P P + W KDG
Sbjct: 1534 QAK----DIKLTIYIPPS----IKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 1585

Query: 260  QDIAPGSNWRRLY----SHLATDSVDPADSGNYSCMAGNKSGDVK---YVTYMVNVLEHA 312
            Q I   S  + LY     +L       +DS  Y+C   N +G  +   +V   V  +   
Sbjct: 1586 QPIMSSS--QALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEG 1643

Query: 313  SISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPI--HPSARHLTAGNGLKISGV 370
            +++  L  Q+V +  ++   C   GNP+P  TW  +  P+  + + R    G  L+I   
Sbjct: 1644 NLATPLNKQVV-IAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSA 1702

Query: 371  TVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAK--VADGDFVTLSCNA 428
               D G Y CVA +  G       ++ E D    P I     ++   V   + + L C+ 
Sbjct: 1703 QEIDRGQYICVATSVAG----EKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHV 1758

Query: 429  SGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQ 488
            +G P P I W     LI       +    RK                V++QA  S     
Sbjct: 1759 TGSPPPTIMWLKDGQLIDERDGFKILLNGRK---------------LVIAQAQVS----- 1798

Query: 489  AVTQEHAGKYICEAANEHGTTQAEASLMV 517
                 + G Y C AAN  G  + E  + V
Sbjct: 1799 -----NTGLYRCMAANTAGDHKKEFEVTV 1822



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 125/508 (24%), Positives = 193/508 (37%), Gaps = 98/508 (19%)

Query: 43   GGPVVLHCSAQPVTT-RISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANN 101
            G  V + CSA      +I+W  N   + G+  +     GTL I +      G Y CLA+N
Sbjct: 626  GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASN 685

Query: 102  SIGA--------IVSGPATVSV-----AVLGDFGSSTKHVITAEEKSAGFIGCRVPESNP 148
            S G          +  P  + V       LGD       +   E K++G          P
Sbjct: 686  SAGTDKQNSTLRYIEAPKLMVVQSELLVALGD-------ITVMECKTSGI---------P 729

Query: 149  KAEVRYKIRGKWLEHSTENYLILPS--GNLQILNVSLEDKGSYKCAAYNP---VTHQLKV 203
              +V++  +G  LE     +LI+    G L+I      D G Y C A N     T ++ +
Sbjct: 730  PPQVKW-FKGD-LELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITL 787

Query: 204  EPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLK-DGQDI 262
            +     + +  P+   + I              S VTL C V G P P + W + D   I
Sbjct: 788  DVGSPPVFIQEPADVSMEI-------------GSNVTLPCYVQGYPEPTIKWRRLDNMPI 834

Query: 263  APGSNWRRLYSHLATDSVD-----PADSGNYSCMAGNKSGDVK-----YVTYMVNVL--E 310
                      S L T ++       +D G Y C A N+ G ++      VT +V  L   
Sbjct: 835  FSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGI 894

Query: 311  HASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNG-LKISG 369
              S++  ++ Q ++L  T+     + GNP P   W  N+  +  +       +G L I  
Sbjct: 895  SPSVANVIEGQQLTLPCTL-----LAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIER 949

Query: 370  VTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNAS 429
            V ++D G Y CVA N  G  + T  + +       P I          +G  VTL C AS
Sbjct: 950  VQLQDGGEYTCVASNVAGTNNKTTSVVVH----VLPTIQHGQQILSTIEGIPVTLPCKAS 1005

Query: 430  GLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQA 489
            G P P + W        S   +++ + S K                  S     SL++ +
Sbjct: 1006 GNPKPSVIW--------SKKGELISTSSAK-----------------FSAGADGSLYVVS 1040

Query: 490  VTQEHAGKYICEAANEHGTTQAEASLMV 517
               E +G+Y+C A N  G  + +  L V
Sbjct: 1041 PGGEESGEYVCTATNTAGYAKRKVQLTV 1068



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 95/374 (25%), Positives = 152/374 (40%), Gaps = 45/374 (12%)

Query: 47   VLHCSAQPVTT-RISWLHNGKTLDGNL-EHVKIHQGTLTILSLNSSLLGYYQCLANNSIG 104
            +L C A  + T  I+W  +   L   L ++     G L + ++     G+Y C+ANN+ G
Sbjct: 4187 ILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAG 4246

Query: 105  AIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHS 164
                   TVS+ V         HV+    +  G +     E   +  +  K  G  L   
Sbjct: 4247 ---EDTHTVSLTV---------HVLPTFTELPGDVSLNKGE---QLRLSCKATGIPLPKL 4291

Query: 165  TE--NYLILPS--------GNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSR 214
            T   N  I+P+          L I  VS ED G+Y C A N V     V+ IG   +   
Sbjct: 4292 TWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGF---VKAIGFVYVKEP 4348

Query: 215  P---SSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRL 271
            P        + + P    A+         L C V G P P + W + G DI      R+L
Sbjct: 4349 PVFKGDYPSNWIEPLGGNAI---------LNCEVKGDPTPTIQWNRKGVDIEISHRIRQL 4399

Query: 272  YS-HLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVH 330
             +  LA       D+G+Y+C+A N++G V+  +  + +     I+    + +++ G  + 
Sbjct: 4400 GNGSLAIYGTVNEDAGDYTCVATNEAGVVER-SMSLTLQSPPIITLEPVETVINAGGKII 4458

Query: 331  FTCDVHGNPAPNCTWFHNAQPIHPSAR-HLTAGNGLKISGVTVEDVGMYQCVADNGIGFM 389
              C   G P P  TW      I    R ++ + N L I+    ED   ++CVA N +G +
Sbjct: 4459 LNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSV 4518

Query: 390  HSTGRLEIENDGGF 403
                 + ++  GGF
Sbjct: 4519 LVRVPVIVQVHGGF 4532



 Score = 38.5 bits (88), Expect = 0.041
 Identities = 26/97 (26%), Positives = 45/97 (46%), Gaps = 4/97 (4%)

Query: 22   SVSSDLAPYFTSEPLSAVQKLGGPVVLHCSA--QPVTTRISWLHNGKTLDGNLEHVKIHQ 79
            S++    P  T EP+  V   GG ++L+C A  +P  T I+W   G ++  +     +  
Sbjct: 4433 SLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPT-ITWSRQGHSISWDDRVNVLSN 4491

Query: 80   GTLTILSLNSSLLGYYQCLANNSIGAI-VSGPATVSV 115
             +L I          ++C+A N +G++ V  P  V V
Sbjct: 4492 NSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQV 4528


>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
          Length = 1018

 Score =  142 bits (358), Expect = 2e-33
 Identities = 208/989 (21%), Positives = 355/989 (35%), Gaps = 205/989 (20%)

Query: 21  SSVSSDLAPYFTSEPLSAV---QKLGGPVVLHCSAQPVTTRI-SWLHNGKTLDGNLEHVK 76
           S       P F  +P++ +   + L G V L+C A+     +  W  N   +D   +   
Sbjct: 33  SEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYS 92

Query: 77  IHQGTLTILSLNSSL-LGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKS 135
           +  G L I + +     G Y CLA+N+ G + S  AT+S   L  F    +  +  +E  
Sbjct: 93  MVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGK 152

Query: 136 AGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILP--------SGNLQILNVSLEDKG 187
              + C  P   P  ++ Y+    WL +    ++ +         +GNL I NV   DKG
Sbjct: 153 GMVLLCDPPYHFPD-DLSYR----WLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKG 207

Query: 188 SYKCAAYNPVTHQ------LKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTL 241
           +Y C   +P   +      + + PI  +   ++P   D+ +      + +  L    VTL
Sbjct: 208 NYSCFVSSPSITKSVFSKFIPLIPIPER--TTKPYPADIVV----QFKDVYALMGQNVTL 261

Query: 242 ECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVK- 300
           EC   G P P + W K  + +   +      + L   ++   D G Y C A N  G  K 
Sbjct: 262 ECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKH 321

Query: 301 ----YVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSA 356
               YV      +EH      + D  V +G+ +++ C   G P P   W  N    H   
Sbjct: 322 QARIYVQAFPEWVEH------INDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGE 375

Query: 357 RHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKV 416
                   L++  VT E+ GMYQC+A+N  G +++   L+I       P     P+  K+
Sbjct: 376 --------LRLYDVTFENAGMYQCIAENTYGAIYANAELKIL---ALAPTFEMNPMKKKI 424

Query: 417 --ADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVY 474
             A G  V + C     P P   W        S  ++ L + SR                
Sbjct: 425 LAAKGGRVIIECKPKAAPKPKFSW--------SKGTEWLVNSSR---------------- 460

Query: 475 FVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMV--------VPFETN-TK 525
            ++ + G  SL I  +T+   G Y C A N  G   +  +L++         P   + T 
Sbjct: 461 ILIWEDG--SLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITV 518

Query: 526 AETVTLPDAAQND----------------DRSKR----------DGSETGLLSSFPVKVH 559
            E  T+  AA  D                D +K           D +   L+ +  +K H
Sbjct: 519 GENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLK-H 577

Query: 560 PSAVESAPEKNASGISVPDAPIILSPP--------QTHTPDTYNLVWRAGKDGGLPINAY 611
                   +      S     ++  PP        +     +  L W  G D   PI+ Y
Sbjct: 578 AGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKY 637

Query: 612 FVKYRKLDDGVGMLGSWHTVR-----VPGSENELHLAELEPSSLYEVLMVARSAAGEGQP 666
            ++ + +     +   W   +     + G+       +L P   YE  +VA +  G G+P
Sbjct: 638 TIQTKTI-----LSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEP 692

Query: 667 AMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDR 726
           ++ + R           T  ++P V                               AP  
Sbjct: 693 SIPSNRI---------KTDGAAPNV-------------------------------APSD 712

Query: 727 PTISTASETSVYVTWIPRA------NGGSPITAFK----VEYKRMRTSNWLVAAEDIPPS 776
                     + +TW P +      N    I AFK     E+K++  +N        P +
Sbjct: 713 VGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTN--------PDT 764

Query: 777 KLSV-EVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYT 835
              V +  ++ P + ++ +V A N+ G+        PY +V   N     P   P     
Sbjct: 765 GRYVHKDETMSPSTAFQVKVKAFNNKGDG-------PYSLVAVINSAQDAPSEAPTEVGV 817

Query: 836 EAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQ 895
           + +S ++I + W ++        ++ + I Y     D +    R  V   +    + +L 
Sbjct: 818 KVLSSSEISVHWEHVLEK----IVESYQIRYWAA-HDKEEAANRVQVTSQEYSARLENLL 872

Query: 896 PETSYDIKMQCFNEGGESEFSNVMICETK 924
           P+T Y I++   N  G    S+++   TK
Sbjct: 873 PDTQYFIEVGACNSAGCGPPSDMIEAFTK 901


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
           sapiens]
          Length = 1386

 Score =  139 bits (349), Expect = 2e-32
 Identities = 158/681 (23%), Positives = 257/681 (37%), Gaps = 109/681 (16%)

Query: 26  DLAPYFTSEPLSAVQKLGGPVVLHCSAQP-VTTRISWLHNGKTLDGNLEHVKIHQGTLTI 84
           D  P    +P   +   G P  L C A+      I W  NG  +    E  + H+  L  
Sbjct: 61  DAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120

Query: 85  LSLNSSLL----------GYYQCLANNSIGAIVSGPATVSVAVL-GDFGSSTKHVITAEE 133
            +L    +          G Y C+A N +GA  S  A++ VAVL  DF  S  +V+ A  
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG 180

Query: 134 KSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAA 193
           + A  + C  P  +P+  V ++  G  L+   E  + +  G L + +    D G Y C A
Sbjct: 181 EPA-VLECVPPRGHPEPSVSWRKDGARLKEE-EGRITIRGGKLMMSHTLKSDAGMYVCVA 238

Query: 194 YNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQV 253
            N      +       +++ RPS     +  P +     VL+ +PVT  C V G P P++
Sbjct: 239 SNMAGE--RESAAAEVMVLERPS----FLRRPVNQ---VVLADAPVTFLCEVKGDPPPRL 289

Query: 254 YWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHAS 313
            W K+  ++  G    R    L    V   D G Y+C+A N  G  +  +  ++V     
Sbjct: 290 RWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAE-ASGSLSVHVPPQ 348

Query: 314 ISKGLQDQIVSLGATVHFTCDVHGNPAPNCTW--------FHNAQPIHPSARHLTAGNG- 364
           +    QDQ+ + G +V F C+  GNP P   W           +Q + P+ R   +  G 
Sbjct: 349 LVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQ 408

Query: 365 LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDG--GFKPVIITAPVSAKVADGDFV 422
           L I+ V   D G Y C A +  G + +   LEI+     G  PVI+  P +  +  G  V
Sbjct: 409 LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSV 468

Query: 423 TLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGA 482
            L C  +G P P +RW                         + +G  L+           
Sbjct: 469 WLPCRVTGNPQPSVRW-------------------------KKDGQWLQGDDLQFKTMAN 503

Query: 483 SSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSK 542
            +L+I  V +   G Y C A +  G       L                           
Sbjct: 504 GTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLK-------------------------- 537

Query: 543 RDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGK 602
                  +   + V   P    S+P         P  P++       T ++  L W+   
Sbjct: 538 -------MREDWGVSPDPPTEPSSPP------GAPSQPVVTE----ITKNSITLTWKPNP 580

Query: 603 DGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELH-LAELEPSSLYEVLMVARSAA 661
             G  + +Y ++      G     +W TV   G + E H ++ L+P+++Y  L+ A  A 
Sbjct: 581 QTGAAVTSYVIEAFSPAAG----NTWRTV-ADGVQLETHTVSGLQPNTIYLFLVRAVGAW 635

Query: 662 GEGQPAMLTFRTSKEKTASSK 682
           G  +P+ ++     + ++ S+
Sbjct: 636 GLSEPSPVSEPVRTQDSSPSR 656



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 166/754 (22%), Positives = 265/754 (35%), Gaps = 148/754 (19%)

Query: 231 LAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSV---------- 280
           L V    P TL C   G P P + W K+G  +A      R +  L               
Sbjct: 73  LLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGR 132

Query: 281 -DPADSGNYSCMAGNKSGDV--KYVTYMVNVLEHASISKGLQDQIVSLGATVHFTC-DVH 336
               D G Y+C+A N  G    +  +  V VL      +   + +V++G      C    
Sbjct: 133 RARPDEGVYTCVARNYLGAAASRNASLEVAVLRD-DFRQSPGNVVVAVGEPAVLECVPPR 191

Query: 337 GNPAPNCTWFHNAQPIHPSARHLTAGNG-LKISGVTVEDVGMYQCVADNGIGFMHSTGRL 395
           G+P P+ +W  +   +      +T   G L +S     D GMY CVA N  G   S    
Sbjct: 192 GHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAE 251

Query: 396 EIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRS 455
            +  +   +P  +  PV+  V     VT  C   G P P +RW                 
Sbjct: 252 VMVLE---RPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRW----------------- 291

Query: 456 KSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASL 515
             RK     P G      Y + S     SL I  V+ E  G Y C A N  G  +A  SL
Sbjct: 292 --RKEDGELPTGR-----YEIRSD---HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSL 341

Query: 516 MV-VPFETNTK--------AETVTLPDAAQNDDRS----KRDGSETGLLSS--------F 554
            V VP +  T+         E+V      + +       +++GS+  L  S        F
Sbjct: 342 SVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRF 401

Query: 555 PVKVHPSAVESAPEKNASGISVPDA------------------------PIILSPPQTHT 590
            V        +A ++  +G  V  A                        P+IL  P   T
Sbjct: 402 SVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQT 461

Query: 591 PDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSL 650
               + VW   +  G P  +  V+++K  DG  + G     +   +   L++A ++   +
Sbjct: 462 LVLGSSVWLPCRVTGNPQPS--VRWKK--DGQWLQGDDLQFKTMAN-GTLYIANVQEMDM 516

Query: 651 YEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVV 710
                VA+S+ GE   +           +    T+ SSPP                    
Sbjct: 517 GFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPP-------------------- 556

Query: 711 LTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVE-YKRMRTSNWLVA 769
                       AP +P ++  ++ S+ +TW P    G+ +T++ +E +     + W   
Sbjct: 557 -----------GAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTV 605

Query: 770 AEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITG 829
           A+ +     +V    L+P + Y F V A+  +G S  S  S P   V   +   SRP+  
Sbjct: 606 ADGVQLETHTVS--GLQPNTIYLFLVRAVGAWGLSEPSPVSEP---VRTQDSSPSRPVED 660

Query: 830 P------------HIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDY 877
           P             +     +    + + WT          +QGF + +R    +  S  
Sbjct: 661 PWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTV---DGPVQLVQGFRVSWRVAGPEGGSWT 717

Query: 878 KRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGG 911
             D+   S+Q  ++  L P T   IK+Q   + G
Sbjct: 718 MLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEG 751



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 48/188 (25%), Positives = 74/188 (39%), Gaps = 20/188 (10%)

Query: 22  SVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQP-VTTRISWLHNG--------KTLDGNL 72
           S+S  + P   ++P   +   G  V   C  +      I W   G        ++L    
Sbjct: 340 SLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTG 399

Query: 73  EHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVI--- 129
                 +G L I ++     GYY C A +  G+I+   A   + + G        VI   
Sbjct: 400 RFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSIL---AKALLEIKGASLDGLPPVILQG 456

Query: 130 ----TAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLED 185
               T    S+ ++ CRV   NP+  VR+K  G+WL+     +  + +G L I NV   D
Sbjct: 457 PANQTLVLGSSVWLPCRVT-GNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMD 515

Query: 186 KGSYKCAA 193
            G Y C A
Sbjct: 516 MGFYSCVA 523


>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
           sapiens]
          Length = 848

 Score =  137 bits (346), Expect = 5e-32
 Identities = 168/711 (23%), Positives = 276/711 (38%), Gaps = 117/711 (16%)

Query: 59  ISWLH-NGKTLDGNLEHVKI-----HQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPAT 112
           ISW   NG+ L  N + + +        TLTI + N    G Y+C+     G+     AT
Sbjct: 52  ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGS--ESEAT 109

Query: 113 VSVAVLGDFGSSTKHVITAEEKSAG---FIGCRVPESNPKAEV-RYKIRGKWLEHSTENY 168
           V+V +        K+  T +E   G    I C V  S P   + ++K R   L+     +
Sbjct: 110 VNVKIFQKL--MFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-F 166

Query: 169 LILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHS 228
           ++L +  LQI  +   D+G+Y+C        ++  + I  +++V+ P +           
Sbjct: 167 IVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIVNVPPTIQAR---QNIV 221

Query: 229 QALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLY-----SHLATDSVDPA 283
            A A L +S VTL C   G P P + W KDG+ I    +  +       S L    VD  
Sbjct: 222 NATANLGQS-VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN 280

Query: 284 DSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNC 343
           D   Y C+A NK+G+ +  T  + V     I+       + L   V  TC+  G+P P+ 
Sbjct: 281 DEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSI 339

Query: 344 TWFHNAQPIHPSAR----HLTAGNGLKISGVTVE-----DVGMYQCVADNGIGFMHSTGR 394
           TW  + + I    +    H+   +  ++S +T++     D G Y C A N IG    +  
Sbjct: 340 TWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY 399

Query: 395 LEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLR 454
           LE++    + P  +  PV+    +G+ V ++C     P   I W+    L+ S       
Sbjct: 400 LEVQ----YAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPS------- 447

Query: 455 SKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEAS 514
             S  S +             + +   AS L +   ++   G Y C A N  G    E  
Sbjct: 448 --SNYSNIK------------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493

Query: 515 LM------------VVPFETNT------------------KAETVTLPDAAQNDD-RSKR 543
           L+            V P+ +                    KAE   + +   +      +
Sbjct: 494 LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553

Query: 544 DGSETGLLSSFPVKVHPSAVESAPEKNASGI-SVPDAPIILSPPQTHTPDTYNLVWRAGK 602
           + S  G+++   +K   +        N  G+  +  A    + P    P    L  + G+
Sbjct: 554 EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE 613

Query: 603 -------------DGGLPINAYFVKYRKLDDGVGMLGSWH-TVRVPGSENELHLAELEPS 648
                        DGG PI  Y V+YR L         W   +R+P   + + L  L+ +
Sbjct: 614 DGNSIKVNLIKQDDGGSPIRHYLVRYRALS------SEWKPEIRLPSGSDHVMLKSLDWN 667

Query: 649 SLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVV 699
           + YEV +VA +  G+ + A   FRTS + TA   N    SP  G+    +V
Sbjct: 668 AEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN---GSPTSGLSTGAIV 715



 Score =  103 bits (257), Expect = 1e-21
 Identities = 161/697 (23%), Positives = 259/697 (37%), Gaps = 140/697 (20%)

Query: 173 SGNLQILNVSLEDKGSYKCAAYNPVTHQLKVE---PIGRKLLVSRPSSDDVHILHPTHSQ 229
           S  L I N +++D G YKC        + +      I +KL+             PT  +
Sbjct: 78  SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---------PTPQE 128

Query: 230 ALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLY---SHLATDSVDPADSG 286
                    V +  VVS +P P + W   G+D+    + R +    ++L    +   D G
Sbjct: 129 FRE--GEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEG 185

Query: 287 NYSC---MAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNC 343
            Y C   +      + K +  +VNV       + + +   +LG +V   CD  G P P  
Sbjct: 186 TYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTM 245

Query: 344 TWFHNAQPIHPSA---RHLTAGNG--LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIE 398
           +W  + + I       +++ + +   L I  V   D   Y C+A+N  G   +T  L++ 
Sbjct: 246 SWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305

Query: 399 NDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSR 458
                KP I        +   + VTL+C ASG P+P I W  S   I+S           
Sbjct: 306 A----KPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISS----------- 350

Query: 459 KSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHG----------- 507
                  E   L+    V S A  SSL ++++    AG+YIC A+N  G           
Sbjct: 351 -------EEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403

Query: 508 -TTQAEASLMVVPFE---TNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVH--PS 561
              + +  + V  +E    N   E    P A  +     RDG      +   +K++  PS
Sbjct: 404 YAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS---WFRDGQLLPSSNYSNIKIYNTPS 460

Query: 562 A--VESAPEKN----------ASGISVPDAPIIL------SPPQTHTPDTYNLVWRAGKD 603
           A  +E  P+             + I       IL      S P     + Y+   +   D
Sbjct: 461 ASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFD 520

Query: 604 -----GGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVAR 658
                GG+PI  Y  ++R + + V     W+  +    E  + +  L+P + Y V + A 
Sbjct: 521 EPEATGGVPILKYKAEWRAVGEEVWH-SKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579

Query: 659 SAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHS 718
           +  G G+ +           AS   TQ           PV                    
Sbjct: 580 NGKGLGEIS----------AASEFKTQ-----------PV-------------------Q 599

Query: 719 GVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKL 778
           G P AP           S+ V  I + +GGSPI  + V Y+ + +S W      +P    
Sbjct: 600 GEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL-SSEWKPEIR-LPSGSD 657

Query: 779 SVEVRSLEPGSTYKFRVIAINHYGES------FRSSA 809
            V ++SL+  + Y+  V+A N  G+S      FR+SA
Sbjct: 658 HVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSA 694



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 61/277 (22%), Positives = 110/277 (39%), Gaps = 43/277 (15%)

Query: 721 PEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLS- 779
           P +P    +   S T+      P A GG PI  +K E++ +    W     D   + +  
Sbjct: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559

Query: 780 -VEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITG-PHIAYTEA 837
            V +  L+P +TY  R+ A+N  G    S+AS           F ++P+ G P     E 
Sbjct: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAAS----------EFKTQPVQGEPSAPKLEG 609

Query: 838 -VSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWH-MIGHLQ 895
            + +    +K   I   +  +PI+ + + YR       S++K ++   S   H M+  L 
Sbjct: 610 QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL----SSEWKPEIRLPSGSDHVMLKSLD 665

Query: 896 PETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPA 955
               Y++ +   N+ G+S+ ++ +   +       A+  P   LST              
Sbjct: 666 WNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTG------------- 712

Query: 956 TSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNR 992
                       IVG ++ + VL+L+V    C + N+
Sbjct: 713 -----------AIVGILIVIFVLLLVVVDITCYFLNK 738


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  137 bits (344), Expect = 8e-32
 Identities = 130/449 (28%), Positives = 185/449 (41%), Gaps = 59/449 (13%)

Query: 138 FIGCRVPESNPKAEVRYKIRGKWLEHSTENYL-ILPSGNLQILNVSLEDKGSYKCAAYNP 196
           +  CR  E NPK E+ +      L   T++ L +L  G L I N    D+G Y+C A N 
Sbjct: 264 YFTCRA-EGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKN- 321

Query: 197 VTHQLKVEPIGRKLLVS--RPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVY 254
           V  ++K + +  +   S  RP+     ++ P +++   VL    VTLEC  +G P P++ 
Sbjct: 322 VAGEVKTQEVTLRYFGSPARPT----FVIQPQNTE---VLVGESVTLECSATGHPPPRIS 374

Query: 255 WLKDGQDIAPGSNWRRLYSH--LATDSVDPADSGNYSCMAGNKSGDVKYVTYM-VNVLEH 311
           W +  +   P      +     L   +V   DSG Y+C A N    V    ++ V  L  
Sbjct: 375 WTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQ 434

Query: 312 ASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNG-LKISGV 370
            +++   QD++V  G TV F C+  GNP P   W      +    RHL   +G L+ISGV
Sbjct: 435 FTVTP--QDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGV 492

Query: 371 TVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASG 430
            + D G Y+C A N IG       L ++      PV  + P    V  G  V L C++ G
Sbjct: 493 ALHDQGQYECQAVNIIGSQKVVAHLTVQ--PRVTPVFASIPSDTTVEVGANVQLPCSSQG 550

Query: 431 LPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAV 490
            P P I W         +   V  ++S K  +S PEG                 L I  V
Sbjct: 551 EPEPAITW---------NKDGVQVTESGKFHIS-PEGF----------------LTINDV 584

Query: 491 TQEHAGKYICEAANEHGTTQAEASLMV---------VPFETNTKAETVTLPDAAQNDDRS 541
               AG+Y C A N  G+      L V          PF   +  E +   D A N  R+
Sbjct: 585 GPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRT 644

Query: 542 ----KRDGSETGLLSSFPVKVHPSAVESA 566
                R  S   LL+ F     P  VE A
Sbjct: 645 HLFDSRPRSPNDLLALFRYPRDPYTVEQA 673



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 100/373 (26%), Positives = 137/373 (36%), Gaps = 31/373 (8%)

Query: 29  PYFTSEPLSAVQKLGGPVVLHCSAQP-VTTRISWLHNGKTL----DGNLEHVKIHQGTLT 83
           P  TSEP  A    G  V   C A+      I WL N   L    D  L    +  GTL 
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLN--LLDDGTLM 303

Query: 84  ILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAE-EKSAGFIGCR 142
           I +   +  G YQC+A N     V+G        L  FGS  +     + + +   +G  
Sbjct: 304 IQNTQETDQGIYQCMAKN-----VAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGES 358

Query: 143 V-----PESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPV 197
           V        +P   + +    +          I PSG L I NV   D G Y C+A N +
Sbjct: 359 VTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNI 418

Query: 198 THQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLK 257
                V      ++ + P             Q   V+    V  +C   G P P + W K
Sbjct: 419 D---SVHATAFIIVQALPQ-------FTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK 468

Query: 258 DGQDIAPGSNWRRLYS-HLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISK 316
            G  ++       L S  L    V   D G Y C A N  G  K V ++        +  
Sbjct: 469 GGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFA 528

Query: 317 GL-QDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSAR-HLTAGNGLKISGVTVED 374
            +  D  V +GA V   C   G P P  TW  +   +  S + H++    L I+ V   D
Sbjct: 529 SIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPAD 588

Query: 375 VGMYQCVADNGIG 387
            G Y+CVA N IG
Sbjct: 589 AGRYECVARNTIG 601



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 65/228 (28%), Positives = 98/228 (42%), Gaps = 32/228 (14%)

Query: 310 EHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIH---PSARHLTAGNGLK 366
           E   I+   QD  V+ G TV+FTC   GNP P   W  N   +     S  +L     L 
Sbjct: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303

Query: 367 ISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGG-FKPVIITAPVSAKVADGDFVTLS 425
           I      D G+YQC+A N  G +  T  + +   G   +P  +  P + +V  G+ VTL 
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEV-KTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLE 362

Query: 426 CNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSL 485
           C+A+G P P I W                ++  ++ L     +N+ P         +  L
Sbjct: 363 CSATGHPPPRISW----------------TRGDRTPLPVDPRVNITP---------SGGL 397

Query: 486 HIQAVTQEHAGKYICEAANEHGTTQAEASLMV--VPFETNTKAETVTL 531
           +IQ V Q  +G+Y C A N   +  A A ++V  +P  T T  + V +
Sbjct: 398 YIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVI 445



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 33/99 (33%), Positives = 49/99 (49%), Gaps = 8/99 (8%)

Query: 22  SVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQ-PVTTRISWLHNGKTLDGNLEHVKIH-- 78
           +V   + P F S P     ++G  V L CS+Q      I+W  +G  +    E  K H  
Sbjct: 518 TVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVT---ESGKFHIS 574

Query: 79  -QGTLTILSLNSSLLGYYQCLANNSIG-AIVSGPATVSV 115
            +G LTI  +  +  G Y+C+A N+IG A VS   +V+V
Sbjct: 575 PEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNV 613


>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score =  134 bits (338), Expect = 4e-31
 Identities = 255/1111 (22%), Positives = 422/1111 (37%), Gaps = 193/1111 (17%)

Query: 30   YFTSEPLSAVQKLGGPVVLHCSA-QPVTTRISWLHNGKTLD--GNLEHVKIHQGTLTILS 86
            YF  EP+  +   G  V+L+CSA    + +I W  +G  L+   +     +  G+L I +
Sbjct: 54   YFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISN 113

Query: 87   L-----NSSLLGYYQCLAN-NSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIG 140
            +     N    GYYQC+A   S+G I+S  A + VA L  F S  +        +A  + 
Sbjct: 114  VVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNA-ILN 172

Query: 141  CRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQ 200
            C V  ++    VR++   + L    +  + LPSG L I N +  D G Y+C   +    +
Sbjct: 173  CEV-NADLVPFVRWEQNRQPL-LLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPK 230

Query: 201  LKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQ 260
               E   + L      SD V +  P  S  + V+ +  V L CV SG+P P + W+K+ +
Sbjct: 231  YSDEVELKVLPDPEVISDLVFLKQP--SPLVRVIGQD-VVLPCVASGLPTPTIKWMKNEE 287

Query: 261  DIAPGSNWRRLY---SHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKG 317
             +   S+ R +      L    V   D+G Y C+A N +  ++     + V       K 
Sbjct: 288  ALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE-AQAELTVQAQPEFLKQ 346

Query: 318  LQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSAR-HLTAGNGLKISGVTVEDVG 376
              +        + F C+V G P P   W  N   + PS    +   + L++ G+   D G
Sbjct: 347  PTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEG 406

Query: 377  MYQCVADNGIGFMHSTGRLEI-ENDGGFKPVIITAP--VSAKVADGDFVTL-----SCNA 428
             YQC+A+N +G   +  +L I E+       + +AP  V A +    F+ L     + + 
Sbjct: 407  FYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDP 466

Query: 429  SGLPVPVIRWYDSHGLI------TSHPSQVLRSKSRKSQLSRPEGLNLEP----VYFVLS 478
             G  +    +Y   G+       TSHP ++  +             NL P    ++ V++
Sbjct: 467  HGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQ-----------NLMPATVYIFRVMA 515

Query: 479  Q----AGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMV---VPFETNTKAETVTL 531
            Q    +G SS  ++  TQ    +    A N      +  S+ V    P   N + +   L
Sbjct: 516  QNKHGSGESSAPLRVETQPEV-QLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKL 574

Query: 532  ------PDAAQNDDRSKRDGSETGL--LSSFPVKVHPSAVESAPEKNASGISVPDAPI-I 582
                   D  Q+ D S    +  GL   + +  +V       A  K+  G+S PD  +  
Sbjct: 575  YYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRV------VAYNKHGPGVSTPDVAVRT 628

Query: 583  LSPPQTHTPDTYNLVWRAGKDGGL------------PINAYFVKYRKLD----------- 619
            LS   +  P   +L  R  K   +             I  Y ++YRK             
Sbjct: 629  LSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVS 688

Query: 620  --------------------------DGVGMLGSW----------HTVRVPGSENELHLA 643
                                      +G G    W             RVP   + LH+ 
Sbjct: 689  GTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVR 748

Query: 644  ELEPSSLYEVL------MVARSAA---GEGQPAMLTFRTS-KEKTASSKNTQASSPPV-- 691
             L  S +          +V R  A   G G P   T +   K++  + +N   SS  V  
Sbjct: 749  PLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVIT 808

Query: 692  ---------GIPKYPVVSEAANNNFGVV--LTDSSRHSGVPE-APDRPTI----STASET 735
                     GIP Y       + +   V     ++ ++ VP+  P  P +    S  S  
Sbjct: 809  LKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHD 868

Query: 736  SVYVTW----IPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTY 791
            ++ +TW    +P+    +    + V +K    +N     ++   + LS  V  L+P + Y
Sbjct: 869  TIRITWADNSLPKHQKITDSRYYTVRWKTNIPAN--TKYKNANATTLSYLVTGLKPNTLY 926

Query: 792  KFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPH--IAYTEAVSDTQIMLKWTY 849
            +F V+         +   S  + +      F   P + P      ++      I++ W  
Sbjct: 927  EFSVMVT-------KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQ- 978

Query: 850  IPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNE 909
             P S  N  I G+ IYY    +    D+  + V G++  H I  L  +T Y  K+Q  N 
Sbjct: 979  -PPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNS 1037

Query: 910  GGESEFSNVMICET----KVKRVP-------GASEYPVKDLST---PPNSLGSGGNVGPA 955
             G    S  +   T       ++P       G     + DL +   PP S GS    G  
Sbjct: 1038 KGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMS-GSNSPHGSP 1096

Query: 956  TSPARSSDMLYLIVGCVLGVMVLILMVFIAM 986
            TSP  S+ +L +IV   +GV+ ++++V IA+
Sbjct: 1097 TSPLDSNMLLVIIVS--VGVITIVVVVIIAV 1125



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 10/131 (7%)

Query: 29  PYFTSEPLSAVQKLGGPVVLHC--SAQPVTTRISWLHNGKTLDGNLEHVKIHQGTLTILS 86
           P F  +P +        +V  C  + +P  T + W+ NG  +  +     + +  L +L 
Sbjct: 341 PEFLKQPTNIYAHESMDIVFECEVTGKPTPT-VKWVKNGDMVIPSDYFKIVKEHNLQVLG 399

Query: 87  LNSSLLGYYQCLANNSIGAIVSGPATV----SVAVLGDFGSSTKHVITAEEKSAGFIGC- 141
           L  S  G+YQC+A N +G   +G   +    + A  G   S+ + V+ A   S  FI   
Sbjct: 400 LVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVV-ASLVSTRFIKLT 458

Query: 142 -RVPESNPKAE 151
            R P S+P  +
Sbjct: 459 WRTPASDPHGD 469


>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
           sapiens]
          Length = 858

 Score =  134 bits (336), Expect = 7e-31
 Identities = 168/721 (23%), Positives = 276/721 (38%), Gaps = 127/721 (17%)

Query: 59  ISWLH-NGKTLDGNLEHVKI-----HQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPAT 112
           ISW   NG+ L  N + + +        TLTI + N    G Y+C+     G+     AT
Sbjct: 52  ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGS--ESEAT 109

Query: 113 VSVAVLGDFGSSTKHVITAEEKSAG---FIGCRVPESNPKAEV-RYKIRGKWLEHSTENY 168
           V+V +        K+  T +E   G    I C V  S P   + ++K R   L+     +
Sbjct: 110 VNVKIFQKL--MFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-F 166

Query: 169 LILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHS 228
           ++L +  LQI  +   D+G+Y+C        ++  + I  +++V+ P +           
Sbjct: 167 IVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIVNVPPTIQAR---QNIV 221

Query: 229 QALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLY-----SHLATDSVDPA 283
            A A L +S VTL C   G P P + W KDG+ I    +  +       S L    VD  
Sbjct: 222 NATANLGQS-VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN 280

Query: 284 DSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNC 343
           D   Y C+A NK+G+ +  T  + V     I+       + L   V  TC+  G+P P+ 
Sbjct: 281 DEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSI 339

Query: 344 TWFHNAQPIHPSAR--------------HLTAGNGLKISGVTVE-----DVGMYQCVADN 384
           TW  + + I    +              H+   +  ++S +T++     D G Y C A N
Sbjct: 340 TWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASN 399

Query: 385 GIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGL 444
            IG    +  LE++    + P  +  PV+    +G+ V ++C     P   I W+    L
Sbjct: 400 TIGQDSQSMYLEVQ----YAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL 454

Query: 445 ITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAAN 504
           + S         S  S +             + +   AS L +   ++   G Y C A N
Sbjct: 455 LPS---------SNYSNIK------------IYNTPSASYLEVTPDSENDFGNYNCTAVN 493

Query: 505 EHGTTQAEASLM------------VVPFETNT------------------KAETVTLPDA 534
             G    E  L+            V P+ +                    KAE   + + 
Sbjct: 494 RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 553

Query: 535 AQNDD-RSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGI-SVPDAPIILSPPQTHTPD 592
             +      ++ S  G+++   +K   +        N  G+  +  A    + P    P 
Sbjct: 554 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 613

Query: 593 TYNLVWRAGK-------------DGGLPINAYFVKYRKLDDGVGMLGSWH-TVRVPGSEN 638
              L  + G+             DGG PI  Y V+YR L         W   +R+P   +
Sbjct: 614 APKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALS------SEWKPEIRLPSGSD 667

Query: 639 ELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPV 698
            + L  L+ ++ YEV +VA +  G+ + A   FRTS + TA   N    SP  G+    +
Sbjct: 668 HVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN---GSPTSGLSTGAI 724

Query: 699 V 699
           V
Sbjct: 725 V 725



 Score =  108 bits (271), Expect = 2e-23
 Identities = 164/698 (23%), Positives = 264/698 (37%), Gaps = 132/698 (18%)

Query: 173 SGNLQILNVSLEDKGSYKCAAYNPVTHQLKVE---PIGRKLLVSRPSSDDVHILHPTHSQ 229
           S  L I N +++D G YKC        + +      I +KL+             PT  +
Sbjct: 78  SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---------PTPQE 128

Query: 230 ALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLY---SHLATDSVDPADSG 286
                    V +  VVS +P P + W   G+D+    + R +    ++L    +   D G
Sbjct: 129 FRE--GEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEG 185

Query: 287 NYSC---MAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNC 343
            Y C   +      + K +  +VNV       + + +   +LG +V   CD  G P P  
Sbjct: 186 TYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTM 245

Query: 344 TWFHNAQPIHPSA---RHLTAGNG--LKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIE 398
           +W  + + I       +++ + +   L I  V   D   Y C+A+N  G   +T  L++ 
Sbjct: 246 SWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305

Query: 399 NDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSR 458
                KP I        +   + VTL+C ASG P+P I W  S   I+S           
Sbjct: 306 A----KPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSE---------E 352

Query: 459 KSQLSRPEGLN-LEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHG---------- 507
           K+  +RPE    L+    V S A  SSL ++++    AG+YIC A+N  G          
Sbjct: 353 KASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 412

Query: 508 --TTQAEASLMVVPFE---TNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVH--P 560
               + +  + V  +E    N   E    P A  +     RDG      +   +K++  P
Sbjct: 413 QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS---WFRDGQLLPSSNYSNIKIYNTP 469

Query: 561 SA--VESAPEKN----------ASGISVPDAPIIL------SPPQTHTPDTYNLVWRAGK 602
           SA  +E  P+             + I       IL      S P     + Y+   +   
Sbjct: 470 SASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQF 529

Query: 603 D-----GGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVA 657
           D     GG+PI  Y  ++R + + V     W+  +    E  + +  L+P + Y V + A
Sbjct: 530 DEPEATGGVPILKYKAEWRAVGEEVWH-SKWYDAKEASMEGIVTIVGLKPETTYAVRLAA 588

Query: 658 RSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRH 717
            +  G G+ +           AS   TQ           PV                   
Sbjct: 589 LNGKGLGEIS----------AASEFKTQ-----------PV------------------- 608

Query: 718 SGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSK 777
            G P AP           S+ V  I + +GGSPI  + V Y+ + +S W      +P   
Sbjct: 609 QGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL-SSEWKPEIR-LPSGS 666

Query: 778 LSVEVRSLEPGSTYKFRVIAINHYGES------FRSSA 809
             V ++SL+  + Y+  V+A N  G+S      FR+SA
Sbjct: 667 DHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSA 704



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 61/277 (22%), Positives = 110/277 (39%), Gaps = 43/277 (15%)

Query: 721 PEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLS- 779
           P +P    +   S T+      P A GG PI  +K E++ +    W     D   + +  
Sbjct: 510 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 569

Query: 780 -VEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITG-PHIAYTEA 837
            V +  L+P +TY  R+ A+N  G    S+AS           F ++P+ G P     E 
Sbjct: 570 IVTIVGLKPETTYAVRLAALNGKGLGEISAAS----------EFKTQPVQGEPSAPKLEG 619

Query: 838 -VSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWH-MIGHLQ 895
            + +    +K   I   +  +PI+ + + YR       S++K ++   S   H M+  L 
Sbjct: 620 QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL----SSEWKPEIRLPSGSDHVMLKSLD 675

Query: 896 PETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPA 955
               Y++ +   N+ G+S+ ++ +   +       A+  P   LST              
Sbjct: 676 WNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTG------------- 722

Query: 956 TSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNR 992
                       IVG ++ + VL+L+V    C + N+
Sbjct: 723 -----------AIVGILIVIFVLLLVVVDITCYFLNK 748


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,408,034
Number of Sequences: 37866
Number of extensions: 2710739
Number of successful extensions: 14590
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 239
Number of HSP's successfully gapped in prelim test: 217
Number of HSP's that attempted gapping in prelim test: 6008
Number of HSP's gapped (non-prelim): 4075
length of query: 1264
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1150
effective length of database: 13,930,794
effective search space: 16020413100
effective search space used: 16020413100
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.