Search of human proteins with 8393638

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8393638 F11 receptor precursor [Homo sapiens]
         (299 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8393638 F11 receptor precursor [Homo sapiens]                      599   e-171
gi|10864029 junctional adhesion molecule 2 precursor [Homo sapiens]   166   2e-41
gi|21361905 junctional adhesion molecule 3 precursor [Homo sapiens]   162   4e-40
gi|5031561 transmembrane glycoprotein A33 precursor [Homo sapiens]     97   2e-20
gi|21361429 V-set and immunoglobulin domain containing 2 [Homo s...    81   1e-15
gi|118572606 hemicentin 1 [Homo sapiens]                               78   1e-14
gi|62865876 immunoglobulin superfamily, member 11 isoform b [Hom...    73   3e-13
gi|62865874 immunoglobulin superfamily, member 11 isoform a [Hom...    72   5e-13
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                    72   6e-13
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    72   8e-13
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    72   8e-13
gi|4503173 coxsackie virus and adenovirus receptor precursor [Ho...    71   1e-12
gi|61966777 V-set and immunoglobulin domain containing 8 [Homo s...    71   1e-12
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]         69   7e-12
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ...    69   7e-12
gi|32699028 V-set and immunoglobulin domain containing 1 [Homo s...    68   1e-11
gi|110349719 titin isoform N2-A [Homo sapiens]                         67   2e-11
gi|13376115 adipocyte-specific adhesion molecule [Homo sapiens]        65   6e-11
gi|148664205 endothelial cell adhesion molecule [Homo sapiens]         64   2e-10
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...    64   2e-10
gi|13489095 sialoadhesin precursor [Homo sapiens]                      64   2e-10
gi|109150416 peroxidasin [Homo sapiens]                                62   6e-10
gi|121674801 hepatocyte cell adhesion molecule [Homo sapiens]          62   6e-10
gi|139948432 adlican [Homo sapiens]                                    62   6e-10
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]       62   8e-10
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...    60   2e-09
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...    60   2e-09
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...    60   2e-09
gi|6005958 V-set and immunoglobulin domain containing 4 isoform ...    60   3e-09
gi|126517478 peroxidasin homolog-like [Homo sapiens]                   59   5e-09

>gi|8393638 F11 receptor precursor [Homo sapiens]
          Length = 299

 Score =  599 bits (1544), Expect = e-171
 Identities = 299/299 (100%), Positives = 299/299 (100%)

Query: 1   MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRV 60
           MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRV
Sbjct: 1   MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRV 60

Query: 61  EWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYG 120
           EWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYG
Sbjct: 61  EWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYG 120

Query: 121 EVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKST 180
           EVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKST
Sbjct: 121 EVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKST 180

Query: 181 RAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIV 240
           RAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIV
Sbjct: 181 RAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIV 240

Query: 241 AAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQTSSFLV 299
           AAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQTSSFLV
Sbjct: 241 AAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQTSSFLV 299


>gi|10864029 junctional adhesion molecule 2 precursor [Homo sapiens]
          Length = 298

 Score =  166 bits (420), Expect = 2e-41
 Identities = 94/245 (38%), Positives = 137/245 (55%), Gaps = 6/245 (2%)

Query: 57  SPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVS--EE 114
           S R+EWK   G +   V Y   +   +++R   +   I  K+VTR D G Y C VS   E
Sbjct: 58  SSRLEWK-KLGRSVSFVYYQQTLQGDFKNRAEMIDFNIRIKNVTRSDAGKYRCEVSAPSE 116

Query: 115 GGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMP 174
            G +  E  V L VLV P+ P+  +PSSA  G    L C +++G+P  EYTWFKDGI + 
Sbjct: 117 QGQNLEEDTVTLEVLVAPAVPSCEVPSSALSGTVVELRCQDKEGNPAPEYTWFKDGIRLL 176

Query: 175 TNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVER 234
            NP+     +NSSY +N  TG L F+ +S  DTGEYSCEARN  G        RM+  + 
Sbjct: 177 ENPRLGSQSTNSSYTMNTKTGTLQFNTVSKLDTGEYSCEARNSVGYRRCPGK-RMQVDDL 235

Query: 235 NVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQT 294
           N+  I+AAV+V  +++ +   G+ +A  +G+F  +K+ +  K    S+ +  SE +FK T
Sbjct: 236 NISGIIAAVVVVALVISVCGLGVCYAQRKGYF--SKETSFQKSNSSSKATTMSENDFKHT 293

Query: 295 SSFLV 299
            SF++
Sbjct: 294 KSFII 298


>gi|21361905 junctional adhesion molecule 3 precursor [Homo sapiens]
          Length = 355

 Score =  162 bits (409), Expect = 4e-40
 Identities = 99/296 (33%), Positives = 148/296 (50%), Gaps = 14/296 (4%)

Query: 15  FILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAY--SGFSSPRVEWKFDQGDTTRL 72
           F L +L     +G+V + SS     + E   V+LSC    S  S PR+EWK  Q + T  
Sbjct: 63  FFLLLLFRGCLIGAVNLKSSNRTPVVQEFESVELSCIITDSQTSDPRIEWKKIQDEQTTY 122

Query: 73  VCYNNKITASYEDRVTFL-PTGITFKSVTREDTGTYTC-MVSEEGGNSYGEVKVKLIVLV 130
           V ++NKI      R   L  T +   +VTR D+  Y C +V+        E+ ++L V V
Sbjct: 123 VFFDNKIQGDLAGRAEILGKTSLKIWNVTRRDSALYRCEVVARNDRKEIDEIVIELTVQV 182

Query: 131 PPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVL 190
            P  P   +P +  +G  A L C E +G P   Y+W+++ + +PT+ ++   F NSS+ L
Sbjct: 183 KPVTPVCRVPKAVPVGKMATLHCQESEGHPRPHYSWYRNDVPLPTDSRANPRFRNSSFHL 242

Query: 191 NPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLILL 250
           N  TG LVF  +   D+G+Y C A N  G+        ME  + N+G I+  VLV L +L
Sbjct: 243 NSETGTLVFTAVHKDDSGQYYCIASNDAGSARCEEQ-EMEVYDLNIGGIIGGVLVVLAVL 301

Query: 251 GILVFGIWFAYSRGHFDRTKKGTSSKK-------VIYSQPSARSEGEFKQTSSFLV 299
            ++  GI  AY RG+F   K+   S K       V Y +     EG+F+  SSF++
Sbjct: 302 ALITLGICCAYRRGYFINNKQDGESYKNPGKPDGVNYIRTD--EEGDFRHKSSFVI 355


>gi|5031561 transmembrane glycoprotein A33 precursor [Homo sapiens]
          Length = 319

 Score = 96.7 bits (239), Expect = 2e-20
 Identities = 79/291 (27%), Positives = 126/291 (43%), Gaps = 46/291 (15%)

Query: 21  LCSL--ALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPR-----------------VE 61
           LC++   + +++V + +  +R  +   V L C Y   +S R                 V 
Sbjct: 12  LCAVRVTVDAISVETPQDVLRASQGKSVTLPCTYHTSTSSREGLIQWDKLLLTHTERVVI 71

Query: 62  WKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVS---EEGGNS 118
           W F   +      Y N+++ S     +     IT   +T  D GTY C VS   +  GN+
Sbjct: 72  WPFSNKNYIHGELYKNRVSISNNAEQS--DASITIDQLTMADNGTYECSVSLMSDLEGNT 129

Query: 119 YGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPK 178
             + +V+L+VLVPPSKP   I     IGN   LTC  ++GSP  +Y+W +  I+    P 
Sbjct: 130 --KSRVRLLVLVPPSKPECGIEGETIIGNNIQLTCQSKEGSPTPQYSWKRYNILNQEQP- 186

Query: 179 STRAFSNSSYVLNPTTGELV-FDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVG 237
                     +  P +G+ V    +S   +G Y C + N  GT   +  V + +   NV 
Sbjct: 187 ----------LAQPASGQPVSLKNISTDTSGYYICTSSNEEGTQFCNITVAVRSPSMNVA 236

Query: 238 V---IVAAVLVTLILLGILVFGIWFAYSRGHFDRT--KKGTSSKKVIYSQP 283
           +   I   V+  LI++GI+   I+    RG  D T  K+     +  Y +P
Sbjct: 237 LYVGIAVGVVAALIIIGII---IYCCCCRGKDDNTEDKEDARPNREAYEEP 284


>gi|21361429 V-set and immunoglobulin domain containing 2 [Homo
           sapiens]
          Length = 327

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 76/277 (27%), Positives = 118/277 (42%), Gaps = 38/277 (13%)

Query: 21  LCSLALGSVTVHSSEPEVRIPEN-------NPVKLSCAYSGF--SSPRVEWKFDQ----- 66
           LC   LG + +     EV++P            +L+C YS     S  +EW F Q     
Sbjct: 9   LCGALLGFLCLSGLAVEVKVPTEPLSTPLGKTAELTCTYSTSVGDSFALEWSFVQPGKPI 68

Query: 67  GDTTRLVCYNNKI---TASYEDRVTFL---PT----GITFKSVTREDTGTYTCMVSEEGG 116
            ++  ++ + N     T S   RV+ L   PT     +    V   DTGTY C V+    
Sbjct: 69  SESHPILYFTNGHLYPTGSKSKRVSLLQNPPTVGVATLKLTDVHPSDTGTYLCQVNNPPD 128

Query: 117 -NSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPT 175
             + G   + L VLVPPS P  +     ++G    L CS  +G+P   Y W + G     
Sbjct: 129 FYTNGLGLINLTVLVPPSNPLCSQSGQTSVGGSTALRCSSSEGAPKPVYNWVRLGTFPTP 188

Query: 176 NPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERN 235
           +P         S V +  +G+L+   LS + +G Y C A N  G+   S  + +   E +
Sbjct: 189 SP--------GSMVQDEVSGQLILTNLSLTSSGTYRCVATNQMGS--ASCELTLSVTEPS 238

Query: 236 VGVIVAAVLVTLILLGILVFGI-WFAYSRGHFDRTKK 271
            G +  A++   +LLG+L+  +  F   R   +R KK
Sbjct: 239 QGRVAGALIG--VLLGVLLLSVAAFCLVRFQKERGKK 273


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 61/214 (28%), Positives = 84/214 (39%), Gaps = 31/214 (14%)

Query: 29   VTVHSSEPEVRIPE--------NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKIT 80
            VT+H  EP V  P+        NNP+ L C  +G  SP + W+ +             + 
Sbjct: 3980 VTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKE----------GINVN 4029

Query: 81   ASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIP 140
             S  +       G+      RED GTY C+     G + G  K+KL V VPP        
Sbjct: 4030 TSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALG--KIKLNVQVPPVISPHLKE 4087

Query: 141  SSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFD 200
                +     L+C E DG PP + TW KDG          RA   S      ++G L   
Sbjct: 4088 YVIAVDKPITLSC-EADGLPPPDITWHKDG----------RAIVESIRQRVLSSGSLQIA 4136

Query: 201  PLSASDTGEYSCEARNGYGTPMTSNAVRMEAVER 234
             +   D G Y+C A N  G+  TS  + +    R
Sbjct: 4137 FVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPR 4170



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 53/183 (28%), Positives = 77/183 (42%), Gaps = 26/183 (14%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            E+ +  NNP++L+C  SG  +P++ W  D     +             D+V  L  G   
Sbjct: 3537 EISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQ------------TDQVQTLGGGEVL 3584

Query: 97   KSVTR--EDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI-GNRAVLTC 153
            +  T   EDTG YTC+ S   G+   E  V+  V VPP+    + P   T+  NR V   
Sbjct: 3585 RISTAQVEDTGRYTCLASSPAGDDDKEYLVR--VHVPPNIAGTDEPRDITVLRNRQVTLE 3642

Query: 154  SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCE 213
             + D  PP   TW ++G  +   P+  R  S   Y        L  +     DT  Y+C 
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATPR-VRILSGGRY--------LQINNADLGDTANYTCV 3693

Query: 214  ARN 216
            A N
Sbjct: 3694 ASN 3696



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 52/190 (27%), Positives = 75/190 (39%), Gaps = 21/190 (11%)

Query: 30   TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTF 89
            ++  S   V +  NNPV+L C   G  +P + W  D    +    ++N +      R+  
Sbjct: 2013 SISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVS---SFSNGLQVLSGGRI-- 2067

Query: 90   LPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRA 149
                +   S    DTG YTC+     G    ++ ++  V VPP+        S  I    
Sbjct: 2068 ----LALTSAQISDTGRYTCVAVNAAGEKQRDIDLR--VYVPPNIMGEEQNVSVLISQAV 2121

Query: 150  VLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGE 209
             L C + D  PP   TW KDG   P   K   + S +  VL         +     DTG 
Sbjct: 2122 ELLC-QSDAIPPPTLTWLKDG--HPLLKKPGLSISENRSVLK-------IEDAQVQDTGR 2171

Query: 210  YSCEARNGYG 219
            Y+CEA N  G
Sbjct: 2172 YTCEATNVAG 2181



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 55/195 (28%), Positives = 78/195 (40%), Gaps = 24/195 (12%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            E+ +     V L C       P + W  +            ++ + +  R TFLP+G   
Sbjct: 1088 EISVLAGEEVTLPCEVKSLPPPIITWAKE-----------TQLISPFSPRHTFLPSGSMK 1136

Query: 97   KSVTR-EDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSE 155
             + TR  D+G Y C+ +   GN      VKL V VPP            +G R  + C+ 
Sbjct: 1137 ITETRTSDSGMYLCVATNIAGNV--TQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNA 1194

Query: 156  QDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
            Q G+P    TW K G        ST       +V NP  G L  D  + SD G Y+C A 
Sbjct: 1195 Q-GTPLPVITWSKGG--------STMLVDGEHHVSNPD-GTLSIDQATPSDAGIYTCVAT 1244

Query: 216  NGYGTPMTSNAVRME 230
            N  GT  T   + ++
Sbjct: 1245 NIAGTDETEITLHVQ 1259



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 56/210 (26%), Positives = 90/210 (42%), Gaps = 25/210 (11%)

Query: 23  SLALGSVTVHSSEP-EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITA 81
           +L +GS  V   EP +V +   + V L C   G+  P ++W+        +  ++   + 
Sbjct: 786 TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWR----RLDNMPIFSRPFSV 841

Query: 82  SYEDRVTFLPTGITF-KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNI- 139
           S    ++ L TG  F  ++   D GTY C    + G    E  V +  LV P    + I 
Sbjct: 842 S---SISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---LIGIS 895

Query: 140 PSSATI--GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGEL 197
           PS A +  G +  L C+   G+P  E  W K+  ++  NP          Y+   + G L
Sbjct: 896 PSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNP----------YITVRSDGSL 945

Query: 198 VFDPLSASDTGEYSCEARNGYGTPMTSNAV 227
             + +   D GEY+C A N  GT   + +V
Sbjct: 946 HIERVQLQDGGEYTCVASNVAGTNNKTTSV 975



 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 51/193 (26%), Positives = 82/193 (42%), Gaps = 32/193 (16%)

Query: 31   VHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFL 90
            + S+E    + EN+   L C   G  +P + WK D           N + A+   + T  
Sbjct: 4171 IRSTEGHYTVNENSQAILPCVADGIPTPAINWKKD-----------NVLLANLLGKYTAE 4219

Query: 91   PTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPT-VNIPSSATI--G 146
            P G +  ++V  ED+G YTC+ +   G     V + + VL     PT   +P   ++  G
Sbjct: 4220 PYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVL-----PTFTELPGDVSLNKG 4274

Query: 147  NRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASD 206
             +  L+C +  G P  + TW  +  ++P +  S    S           ELV + +S  D
Sbjct: 4275 EQLRLSC-KATGIPLPKLTWTFNNNIIPAHFDSVNGHS-----------ELVIERVSKED 4322

Query: 207  TGEYSCEARNGYG 219
            +G Y C A N  G
Sbjct: 4323 SGTYVCTAENSVG 4335



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 62/213 (29%), Positives = 85/213 (39%), Gaps = 31/213 (14%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--ITFKSVT 100
            +NPV+L C  +G   P + W            Y +    S    +TFL  G  I  +S  
Sbjct: 1935 SNPVQLECKAAGNPVPVITW------------YKDNRLLSGSTSMTFLNRGQIIDIESAQ 1982

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSP 160
              D G Y C+     G +  E+   L V V PS    N   +  + N   L C E  G P
Sbjct: 1983 ISDAGIYKCVAINSAGAT--ELFYSLQVHVAPSISGSNNMVAVVVNNPVRLEC-EARGIP 2039

Query: 161  PSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT 220
                TW KDG     +P S  +FSN   VL+     L       SDTG Y+C A N  G 
Sbjct: 2040 APSLTWLKDG-----SPVS--SFSNGLQVLSGGR-ILALTSAQISDTGRYTCVAVNAAGE 2091

Query: 221  PMTSNAVR------MEAVERNVGVIVAAVLVTL 247
                  +R      +   E+NV V+++  +  L
Sbjct: 2092 KQRDIDLRVYVPPNIMGEEQNVSVLISQAVELL 2124



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 51/184 (27%), Positives = 75/184 (40%), Gaps = 32/184 (17%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRE 102
            NN + L+C  SGF  P + W              N+           +P G T + +  +
Sbjct: 2979 NNFISLTCEVSGFPPPDLSW------------LKNEQPIKLNTNTLIVPGGRTLQIIRAK 3026

Query: 103  --DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI----GNRAVLTCSEQ 156
              D G YTC+   + G S  + K  L V VPPS    +  S + +    G    L C E 
Sbjct: 3027 VSDGGEYTCIAINQAGES--KKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLEC-ES 3083

Query: 157  DGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELV-FDPLSASDTGEYSCEAR 215
            +  PP   TW+K+G          R  + S++V     G+++       SDTG+Y C A 
Sbjct: 3084 NAVPPPVITWYKNG----------RMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAI 3133

Query: 216  NGYG 219
            N  G
Sbjct: 3134 NVAG 3137



 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 50/198 (25%), Positives = 86/198 (43%), Gaps = 30/198 (15%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            +V + +   ++LSC  +G   P++ W F           NN I  ++ D V    + +  
Sbjct: 4268 DVSLNKGEQLRLSCKATGIPLPKLTWTF-----------NNNIIPAHFDSVNG-HSELVI 4315

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVK-VKLIVLVPPSKPTVNIPSS--ATIGNRAVLTC 153
            + V++ED+GTY C       NS G VK +  + +  P     + PS+    +G  A+L C
Sbjct: 4316 ERVSKEDSGTYVCTAE----NSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNC 4371

Query: 154  SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCE 213
             E  G P     W + G+ +  + +  R   N S  +  T  E         D G+Y+C 
Sbjct: 4372 -EVKGDPTPTIQWNRKGVDIEISHR-IRQLGNGSLAIYGTVNE---------DAGDYTCV 4420

Query: 214  ARNGYGTPMTSNAVRMEA 231
            A N  G    S ++ +++
Sbjct: 4421 ATNEAGVVERSMSLTLQS 4438



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 54/193 (27%), Positives = 71/193 (36%), Gaps = 30/193 (15%)

Query: 32   HSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLP 91
            H S   + + E N V L+C  SG   P + W            + +    S  + V  L 
Sbjct: 2390 HRSPENISVVEKNSVSLTCEASGIPLPSITW------------FKDGWPVSLSNSVRILS 2437

Query: 92   TG--ITFKSVTREDTGTYTCMVSEEGGNSYGEVKV-KLIVLVPPSKPTVNIPSSATIGNR 148
             G  +     T ED G YTC+V    G    E K+  L VLVPP     N      +  +
Sbjct: 2438 GGRMLRLMQTTMEDAGQYTCVVRNAAGE---ERKIFGLSVLVPPHIVGENTLEDVKVKEK 2494

Query: 149  --AVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASD 206
                LTC E  G+P  E TW KDG   P          +    L  T        +    
Sbjct: 2495 QSVTLTC-EVTGNPVPEITWHKDG--QPLQEDEAHHIISGGRFLQITN-------VQVPH 2544

Query: 207  TGEYSCEARNGYG 219
            TG Y+C A +  G
Sbjct: 2545 TGRYTCLASSPAG 2557



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 54/189 (28%), Positives = 73/189 (38%), Gaps = 29/189 (15%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--I 94
            EV +  N  V L C   G   P + W F  G    L           +  V  L  G  +
Sbjct: 1462 EVSVVLNRDVALECQVKGTPFPDIHW-FKDGKPLFLG----------DPNVELLDRGQVL 1510

Query: 95   TFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPS--SATIGNRAVLT 152
              K+  R D G Y C VS   G    +  +KL + +PPS    N+ +  S  I +   L 
Sbjct: 1511 HLKNARRNDKGRYQCTVSNAAGKQAKD--IKLTIYIPPSIKGGNVTTDISVLINSLIKLE 1568

Query: 153  CSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDP-LSASDTGEYS 211
            C E  G P    TW+KDG          +   +SS  L    G+ +  P    SD+  Y+
Sbjct: 1569 C-ETRGLPMPAITWYKDG----------QPIMSSSQALYIDKGQYLHIPRAQVSDSATYT 1617

Query: 212  CEARNGYGT 220
            C   N  GT
Sbjct: 1618 CHVANVAGT 1626



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 52/193 (26%), Positives = 80/193 (41%), Gaps = 21/193 (10%)

Query: 30   TVHSSEPEVRIPE-NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVT 88
            ++   E EV +   +NPV L+C  +G   P + W  +              + S E R+ 
Sbjct: 3152 SIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIEN--------SDSLEVRIL 3203

Query: 89   FLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPS--SATIG 146
               + +        D+G YTC+ S   G +  +    L + VPPS     IPS  S  +G
Sbjct: 3204 SGGSKLQIARSQHSDSGNYTCIASNMEGKA--QKYYFLSIQVPPSVAGAEIPSDVSVLLG 3261

Query: 147  NRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASD 206
                L C+  +G P     W KDG  + +        S +   LN      ++  L+ SD
Sbjct: 3262 ENVELVCN-ANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLN------IYGALT-SD 3313

Query: 207  TGEYSCEARNGYG 219
            TG+Y+C A N  G
Sbjct: 3314 TGKYTCVATNPAG 3326



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 51/183 (27%), Positives = 74/183 (40%), Gaps = 28/183 (15%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--ITFKSVT 100
            NNP+ L C  +    P + W  D           + +T+S  D+V  LP G  +      
Sbjct: 2792 NNPISLYCETNAAPPPTLTWYKD----------GHPLTSS--DKVLILPGGRVLQIPRAK 2839

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVN--IPSSATI-GNRAVLTCSEQD 157
             ED G YTC+   E G    +  V+  VLVPP     N  +P   T+  N++ L      
Sbjct: 2840 VEDAGRYTCVAVNEAGEDSLQYDVR--VLVPPIIKGANSDLPEEVTVLVNKSALIECLSS 2897

Query: 158  GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
            GSP    +W KDG   P        F ++  +L     ++       +D G Y C A N 
Sbjct: 2898 GSPAPRNSWQKDG--QPLLEDDHHKFLSNGRILQILNTQI-------TDIGRYVCVAENT 2948

Query: 218  YGT 220
             G+
Sbjct: 2949 AGS 2951



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 48/178 (26%), Positives = 68/178 (38%), Gaps = 22/178 (12%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITFKSVTR 101
            N    L C   G  +PR+ W+ D             + A    R + L  G +  +S   
Sbjct: 3727 NKSTVLECIAEGVPTPRITWRKD-----------GAVLAGNHARYSILENGFLHIQSAHV 3775

Query: 102  EDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPP 161
             DTG Y CM +   G      ++ L V VPPS        +  +  +  L C E  G P 
Sbjct: 3776 TDTGRYLCMATNAAGTD--RRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLAC-EATGIPK 3832

Query: 162  SEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
                W K+G ++  +        NS  +L+  +G LV    S  DT  Y C   NG G
Sbjct: 3833 PSINWRKNGHLLNVDQNQ-----NSYRLLS--SGSLVIISPSVDDTATYECTVTNGAG 3883



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 52/209 (24%), Positives = 74/209 (35%), Gaps = 36/209 (17%)

Query: 34   SEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG 93
            S  EV+I  NN + L C      S  + W            Y +      +D V     G
Sbjct: 2680 SPKEVKIKVNNTLTLECEAYAIPSASLSW------------YKDGQPLKSDDHVNIAANG 2727

Query: 94   ITF--KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTV-----------NIP 140
             T   K     DTG YTC+ S   G    E+   + + VPPS   +           N  
Sbjct: 2728 HTLQIKEAQISDTGRYTCVASNIAGED--ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGE 2785

Query: 141  SSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFD 200
            +   I N  +    E + +PP   TW+KDG  + ++ K          ++ P    L   
Sbjct: 2786 AKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDK---------VLILPGGRVLQIP 2836

Query: 201  PLSASDTGEYSCEARNGYGTPMTSNAVRM 229
                 D G Y+C A N  G       VR+
Sbjct: 2837 RAKVEDAGRYTCVAVNEAGEDSLQYDVRV 2865



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 45/182 (24%), Positives = 73/182 (40%), Gaps = 27/182 (14%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--ITFKSVT 100
            N  ++  C   G   P ++W            +N +     E  ++ L  G  +   SVT
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKW-----------LHNGRELTGREPGISILEDGTLLVIASVT 1329

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP-SKPTVNIPSSATIGNRAVLTCSEQDGS 159
              D G Y C+   E G +  E K  L V VPP  K    + + + + N+      E +G+
Sbjct: 1330 PYDNGEYICVAVNEAGTT--ERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGT 1387

Query: 160  PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELV-FDPLSASDTGEYSCEARNGY 218
            P     W+KD + +          + SS +     G+++     +  D G YSC+A N  
Sbjct: 1388 PSPIIMWYKDNVQV----------TESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIA 1437

Query: 219  GT 220
            GT
Sbjct: 1438 GT 1439



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 43/125 (34%), Positives = 53/125 (42%), Gaps = 8/125 (6%)

Query: 103 DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPS 162
           D G YTC+   E G + G  K+ L V  PP         S  IG+   L C  Q G P  
Sbjct: 766 DAGDYTCVAINEAGRATG--KITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQ-GYPEP 822

Query: 163 EYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPM 222
              W +    +   P  +R FS SS +    TG L    L ASD G Y CEA N +G   
Sbjct: 823 TIKWRR----LDNMPIFSRPFSVSS-ISQLRTGALFILNLWASDKGTYICEAENQFGKIQ 877

Query: 223 TSNAV 227
           +   V
Sbjct: 878 SETTV 882



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 55/201 (27%), Positives = 83/201 (41%), Gaps = 32/201 (15%)

Query: 29   VTVH-------SSEPEVRIPENNPVKLSCAYSGFSSPRVEW-KFDQGDTTRLVCYNNKIT 80
            VTVH       S   E  + +  PV L C  +G  +P + W K DQ   T     N KI 
Sbjct: 1820 VTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNT--AQGNLKIQ 1877

Query: 81   ASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVN-- 138
            +S   RV      +       ED G YTC+ +   G +  +  ++L V  PPS       
Sbjct: 1878 SS--GRV------LQIAKTLLEDAGRYTCVATNAAGET--QQHIQLHVHEPPSLEDAGKM 1927

Query: 139  IPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELV 198
            +  +  + N   L C +  G+P    TW+KD  ++  +   T  F N   +++  + ++ 
Sbjct: 1928 LNETVLVSNPVQLEC-KAAGNPVPVITWYKDNRLLSGSTSMT--FLNRGQIIDIESAQI- 1983

Query: 199  FDPLSASDTGEYSCEARNGYG 219
                  SD G Y C A N  G
Sbjct: 1984 ------SDAGIYKCVAINSAG 1998



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 57/201 (28%), Positives = 75/201 (37%), Gaps = 36/201 (17%)

Query: 28   SVTVHSSEP-EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDR 86
            ++T   S P E+ +     + L C   G   P V W  D     +               
Sbjct: 2291 TITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIK------------AKG 2338

Query: 87   VTFLPTG--ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-----KPTVNI 139
            V  L  G  +  K++   DTG Y C+     G +  + K  L V  PPS     +   NI
Sbjct: 2339 VEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMT--DKKYDLSVHAPPSIIGNHRSPENI 2396

Query: 140  PSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYV-LNPTTGELV 198
              S    N   LTC E  G P    TWFKDG  +  +  S R  S    + L  TT E  
Sbjct: 2397 --SVVEKNSVSLTC-EASGIPLPSITWFKDGWPVSLS-NSVRILSGGRMLRLMQTTME-- 2450

Query: 199  FDPLSASDTGEYSCEARNGYG 219
                   D G+Y+C  RN  G
Sbjct: 2451 -------DAGQYTCVVRNAAG 2464



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 57/222 (25%), Positives = 82/222 (36%), Gaps = 44/222 (19%)

Query: 8    ERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQG 67
            ERK+   F L++L+    +G  T+     +V++ E   V L+C  +G   P + W  D G
Sbjct: 2466 ERKI---FGLSVLVPPHIVGENTLE----DVKVKEKQSVTLTCEVTGNPVPEITWHKD-G 2517

Query: 68   DTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRED---TGTYTCMVSEEGGNSYGEVKV 124
               +            ED    + +G  F  +T      TG YTC+ S   G+      +
Sbjct: 2518 QPLQ------------EDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSL 2565

Query: 125  KLIVLVPPSKPTV-------NIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNP 177
             + V      PT+       N      I N       E    PP+  TWFKDG       
Sbjct: 2566 NVFV-----SPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDG------- 2613

Query: 178  KSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              T   SN +  + P    L        + G YSC A N  G
Sbjct: 2614 --TPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG 2653



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 39/157 (24%), Positives = 63/157 (40%), Gaps = 15/157 (9%)

Query: 66   QGDTTRLVCYNNK-ITASYEDRVTFLPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVK 123
            +GD T  + +N K +      R+  L  G +       ED G YTC+ + E G    E  
Sbjct: 4374 KGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAG--VVERS 4431

Query: 124  VKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAF 183
            + L +  PP      + +    G + +L C +  G P    TW + G  +  + +     
Sbjct: 4432 MSLTLQSPPIITLEPVETVINAGGKIILNC-QATGEPQPTITWSRQGHSISWDDRVNVLS 4490

Query: 184  SNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT 220
            +NS Y+ +              DT E+ C ARN  G+
Sbjct: 4491 NNSLYIAD----------AQKEDTSEFECVARNLMGS 4517



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 39/174 (22%), Positives = 69/174 (39%), Gaps = 23/174 (13%)

Query: 46  VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
           V + C+ +G+  P++ W  +          +  I  S+  R+T   T +  K+   +D G
Sbjct: 629 VSIMCSATGYPKPKIAWTVN----------DMFIVGSHRYRMTSDGT-LFIKNAAPKDAG 677

Query: 106 TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYT 165
            Y C+ S   G       ++ I    P    V       +G+  V+ C +  G PP +  
Sbjct: 678 IYGCLASNSAGTDKQNSTLRYIEA--PKLMVVQSELLVALGDITVMEC-KTSGIPPPQVK 734

Query: 166 WFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           WFK  + +  +         +  +++P  G L        D G+Y+C A N  G
Sbjct: 735 WFKGDLELRPS---------TFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779



 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 38/141 (26%), Positives = 56/141 (39%), Gaps = 13/141 (9%)

Query: 88  TFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGN 147
           T     +  KSV   D G Y CMVS EGG+S     V L V  PP    +    S T G+
Sbjct: 570 TLANLSLELKSVKFNDAGEYHCMVSSEGGSS--AASVFLTVQEPPKVTVMPKNQSFTGGS 627

Query: 148 RAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDT 207
              + CS   G P  +  W  + + +  + +       + ++ N           +  D 
Sbjct: 628 EVSIMCS-ATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKN----------AAPKDA 676

Query: 208 GEYSCEARNGYGTPMTSNAVR 228
           G Y C A N  GT   ++ +R
Sbjct: 677 GIYGCLASNSAGTDKQNSTLR 697



 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 52/195 (26%), Positives = 77/195 (39%), Gaps = 24/195 (12%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            E+ + + +   ++C   G  +P + W  D G    L  +   +T S    V  L    T 
Sbjct: 3444 EITVLKGSSTSMACITDGTPAPSMAWLRD-GQPLGLDAH---LTVSTHGMVLQLLKAET- 3498

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP--SKPTVNIPSSATIGNRAVLTCS 154
                 ED+G YTC+ S E G       +K  VL PP  +    +   S  + N   LTC 
Sbjct: 3499 -----EDSGKYTCIASNEAGEVSKHFILK--VLEPPHINGSEEHEEISVIVNNPLELTCI 3551

Query: 155  EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
               G P  + TW KDG  +P   +          VL  +T ++        DTG Y+C A
Sbjct: 3552 -ASGIPAPKMTWMKDGRPLPQTDQVQTL--GGGEVLRISTAQV-------EDTGRYTCLA 3601

Query: 215  RNGYGTPMTSNAVRM 229
             +  G       VR+
Sbjct: 3602 SSPAGDDDKEYLVRV 3616



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 45/185 (24%), Positives = 70/185 (37%), Gaps = 25/185 (13%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            EV +  N    + C  SG  +PR  W+ D                  +D   FL  G   
Sbjct: 2881 EVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLE------------DDHHKFLSNGRIL 2928

Query: 97   KSVTRE--DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCS 154
            + +  +  D G Y C+     G++  +    L V VPPS       +   + N  +    
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSA--KKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTC 2986

Query: 155  EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
            E  G PP + +W K       N +  +  +N+  V    T +++      SD GEY+C A
Sbjct: 2987 EVSGFPPPDLSWLK-------NEQPIKLNTNTLIVPGGRTLQII--RAKVSDGGEYTCIA 3037

Query: 215  RNGYG 219
             N  G
Sbjct: 3038 INQAG 3042



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 50/191 (26%), Positives = 64/191 (33%), Gaps = 27/191 (14%)

Query: 33   SSEP-EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLP 91
            + EP ++ +  N  V L C       P + W              N        RV  L 
Sbjct: 3625 TDEPRDITVLRNRQVTLECKSDAVPPPVITW------------LRNGERLQATPRVRILS 3672

Query: 92   TG--ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRA 149
             G  +   +    DT  YTC+ S   G +  E    L V VPP+           +    
Sbjct: 3673 GGRYLQINNADLGDTANYTCVASNIAGKTTREFI--LTVNVPPNIKGGPQSLVILLNKST 3730

Query: 150  VLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGE 209
            VL C  + G P    TW KDG V+  N        N         G L       +DTG 
Sbjct: 3731 VLECIAE-GVPTPRITWRKDGAVLAGNHARYSILEN---------GFLHIQSAHVTDTGR 3780

Query: 210  YSCEARNGYGT 220
            Y C A N  GT
Sbjct: 3781 YLCMATNAAGT 3791



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 46/191 (24%), Positives = 68/191 (35%), Gaps = 33/191 (17%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--I 94
            ++ + E N + L C  SG   P + WK             + +      RV  L  G  +
Sbjct: 2205 QLTVIEGNLISLLCESSGIPPPNLIWKKK----------GSPVLTDSMGRVRILSGGRQL 2254

Query: 95   TFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS------ATIGNR 148
                  + D   Y+C+ S   G +  E  +++ +     +PT+    S       T G  
Sbjct: 2255 QISIAEKSDAALYSCVASNVAGTAKKEYNLQVYI-----RPTITNSGSHPTEIIVTRGKS 2309

Query: 149  AVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTG 208
              L C  Q G PP   TW KDG   P          +  ++L           +  SDTG
Sbjct: 2310 ISLECEVQ-GIPPPTVTWMKDG--HPLIKAKGVEILDEGHILQ-------LKNIHVSDTG 2359

Query: 209  EYSCEARNGYG 219
             Y C A N  G
Sbjct: 2360 RYVCVAVNVAG 2370



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 52/199 (26%), Positives = 76/199 (38%), Gaps = 38/199 (19%)

Query: 30   TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTF 89
            T+   +  +   E  PV L C  SG   P V W   +G+   +   + K +A  +  +  
Sbjct: 982  TIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWS-KKGEL--ISTSSAKFSAGADGSLYV 1038

Query: 90   LPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP-----------SKPTVN 138
            +  G        E++G Y C  +   G  Y + KV+L V V P            KP   
Sbjct: 1039 VSPG-------GEESGEYVCTATNTAG--YAKRKVQLTVYVRPRVFGDQRGLSQDKP--- 1086

Query: 139  IPSSATIGNRAVLTCSEQDGSPPSEYTWFKD-GIVMPTNPKSTRAFSNSSYVLNPTTGEL 197
            +  S   G    L C E    PP   TW K+  ++ P +P+ T   S S  +    T   
Sbjct: 1087 VEISVLAGEEVTLPC-EVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRT--- 1142

Query: 198  VFDPLSASDTGEYSCEARN 216
                   SD+G Y C A N
Sbjct: 1143 -------SDSGMYLCVATN 1154



 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 42/180 (23%), Positives = 61/180 (33%), Gaps = 25/180 (13%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK--SVT 100
            N    L C   G  SP + W            Y + +  +    +  +  G   K    T
Sbjct: 1375 NQLTNLFCEVEGTPSPIIMW------------YKDNVQVTESSTIQTVNNGKILKLFRAT 1422

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIG-NRAVLTCSEQDGS 159
             ED G Y+C      G S  +    + VLVPP+    N P+  ++  NR V    +  G+
Sbjct: 1423 PEDAGRYSCKAINIAGTS--QKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGT 1480

Query: 160  PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            P  +  WFKDG  +     +                 L       +D G Y C   N  G
Sbjct: 1481 PFPDIHWFKDGKPLFLGDPNVELLDRGQV--------LHLKNARRNDKGRYQCTVSNAAG 1532



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 41/189 (21%), Positives = 70/189 (37%), Gaps = 25/189 (13%)

Query: 34   SEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG 93
            S+  V + EN  V+L C  +G  +P ++W  D             I +   +R+     G
Sbjct: 3254 SDVSVLLGEN--VELVCNANGIPTPLIQWLKD----------GKPIASGETERIRVSANG 3301

Query: 94   ITFK--SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVL 151
             T         DTG YTC+ +   G       + + V               T+ + ++ 
Sbjct: 3302 STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSIN 3361

Query: 152  TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELV-FDPLSASDTGEY 210
                  G+PP +  W K+G+ +P           SS++     G+++       SD   Y
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPL----------SSHIRLLAAGQVIRIVRAQVSDVAVY 3411

Query: 211  SCEARNGYG 219
            +C A N  G
Sbjct: 3412 TCVASNRAG 3420



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 48/179 (26%), Positives = 70/179 (39%), Gaps = 22/179 (12%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITFKSVTR 101
            N    L+C  +G   P + W+   G    +    N    SY      L +G +   S + 
Sbjct: 3818 NVQTTLACEATGIPKPSINWR-KNGHLLNVDQNQN----SYR----LLSSGSLVIISPSV 3868

Query: 102  EDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPP 161
            +DT TY C V+   G+   +  V L V VPPS          T    AV+TC+   G P 
Sbjct: 3869 DDTATYECTVTNGAGDD--KRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCT-ASGVPF 3925

Query: 162  SEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT 220
                W K+GI +       R  S+ +  +  T           +  G Y+C ARN  G+
Sbjct: 3926 PSIHWTKNGIRLLPRGDGYRILSSGAIEILAT---------QLNHAGRYTCVARNAAGS 3975



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 44/183 (24%), Positives = 70/183 (38%), Gaps = 22/183 (12%)

Query: 40   IPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSV 99
            + ++ P  ++C  SG   P + W     +  RL+   +         +  L T +     
Sbjct: 3908 VTKHAPAVITCTASGVPFPSIHW---TKNGIRLLPRGDGYRILSSGAIEILATQL----- 3959

Query: 100  TREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGS 159
                 G YTC+     G+++    V L V  PP            + N  +L C E  G+
Sbjct: 3960 --NHAGRYTCVARNAAGSAHRH--VTLHVHEPPVIQPQPSELHVILNNPILLPC-EATGT 4014

Query: 160  PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            P    TW K+GI + T        S  ++ + P +G L        D G Y C A+N  G
Sbjct: 4015 PSPFITWQKEGINVNT--------SGRNHAVLP-SGGLQISRAVREDAGTYMCVAQNPAG 4065

Query: 220  TPM 222
            T +
Sbjct: 4066 TAL 4068



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 44/174 (25%), Positives = 64/174 (36%), Gaps = 24/174 (13%)

Query: 48   LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
            L C  +G  SP + W  D             + A+   R+      +   S    D G Y
Sbjct: 1661 LECKAAGNPSPILTWLKD----------GVPVKANDNIRIEAGGKKLEIMSAQEIDRGQY 1710

Query: 108  TCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS--ATIGNRAVLTCSEQDGSPPSEYT 165
             C+ +   G    E+K ++ VLVPP+    +  S     + N   L C    GSPP    
Sbjct: 1711 ICVATSVAGEK--EIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC-HVTGSPPPTIM 1767

Query: 166  WFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            W KDG ++              + +     +LV      S+TG Y C A N  G
Sbjct: 1768 WLKDGQLID---------ERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAG 1812



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 48/204 (23%), Positives = 77/204 (37%), Gaps = 34/204 (16%)

Query: 23   SLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITAS 82
            S  +  V    +  +V +  N+P  L C    +    + W F  G  T L    N     
Sbjct: 2570 SPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITW-FKDG--TPLESNRN----- 2621

Query: 83   YEDRVTFLPTGITFK--SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP--SKPTVN 138
                +  LP G T +  +   ++ G Y+C+ + E G      +VK  V +PP  +K  + 
Sbjct: 2622 ----IRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVK--VYIPPIINKGDLW 2675

Query: 139  IPS------SATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNP 192
             P          + N   L C E    P +  +W+KDG  + ++     A +  +     
Sbjct: 2676 GPGLSPKEVKIKVNNTLTLEC-EAYAIPSASLSWYKDGQPLKSDDHVNIAANGHT----- 2729

Query: 193  TTGELVFDPLSASDTGEYSCEARN 216
                L       SDTG Y+C A N
Sbjct: 2730 ----LQIKEAQISDTGRYTCVASN 2749



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 42/183 (22%), Positives = 65/183 (35%), Gaps = 32/183 (17%)

Query: 43   NNPVKLSCAYSGFSSPRVEWK-----FDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
            NN ++L C  +G   P + W       D+ D  +++    K+  +               
Sbjct: 1749 NNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIA--------------- 1793

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQD 157
                 +TG Y CM +   G+   E +V   V VPP+  +  +     +  + V      +
Sbjct: 1794 QAQVSNTGLYRCMAANTAGDHKKEFEVT--VHVPPTIKSSGLSERVVVKYKPVALQCIAN 1851

Query: 158  GSPPSEYTWFKDGIVMPTN-PKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
            G P    TW KD    P N  +      +S  VL      L        D G Y+C A N
Sbjct: 1852 GIPNPSITWLKDD--QPVNTAQGNLKIQSSGRVLQIAKTLL-------EDAGRYTCVATN 1902

Query: 217  GYG 219
              G
Sbjct: 1903 AAG 1905



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 48/202 (23%), Positives = 73/202 (36%), Gaps = 34/202 (16%)

Query: 23   SLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITAS 82
            S+  G+VT      ++ +  N+ +KL C   G   P + W  D           +   A 
Sbjct: 1547 SIKGGNVTT-----DISVLINSLIKLECETRGLPMPAITWYKDGQPIM------SSSQAL 1595

Query: 83   YEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP---SKPTVNI 139
            Y D+  +L            D+ TYTC V+   G +  E    + V VPP         +
Sbjct: 1596 YIDKGQYLH----IPRAQVSDSATYTCHVANVAGTA--EKSFHVDVYVPPMIEGNLATPL 1649

Query: 140  PSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVF 199
                 I +   L C    G+P    TW KDG+ +  N             +    G    
Sbjct: 1650 NKQVVIAHSLTLECKAA-GNPSPILTWLKDGVPVKANDN-----------IRIEAGGKKL 1697

Query: 200  DPLSAS--DTGEYSCEARNGYG 219
            + +SA   D G+Y C A +  G
Sbjct: 1698 EIMSAQEIDRGQYICVATSVAG 1719



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 47/195 (24%), Positives = 67/195 (34%), Gaps = 28/195 (14%)

Query: 31   VHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTR---LVCYNNKITASYEDRV 87
            +   E  V +  +  V+L C       P + W  D     +   L    N+     ED  
Sbjct: 2106 IMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQ 2165

Query: 88   TFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI-- 145
                          +DTG YTC  +   G +  E    + + VPP+    +  +  T+  
Sbjct: 2166 V-------------QDTGRYTCEATNVAGKT--EKNYNVNIWVPPNIGGSDELTQLTVIE 2210

Query: 146  GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSAS 205
            GN   L C E  G PP    W K G  + T+        +    L  +  E        S
Sbjct: 2211 GNLISLLC-ESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE-------KS 2262

Query: 206  DTGEYSCEARNGYGT 220
            D   YSC A N  GT
Sbjct: 2263 DAALYSCVASNVAGT 2277



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 37/129 (28%), Positives = 51/129 (39%), Gaps = 17/129 (13%)

Query: 99  VTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI--GNRAVLTCSEQ 156
           VT  D G Y C+     G   G  +    V  PP  P + +P++ T+  G RAVLTC   
Sbjct: 489 VTLSDEGFYECIAVSSAGT--GRAQTFFDVSEPP--PVIQVPNNVTVTPGERAVLTCL-I 543

Query: 157 DGSPPSEYTWFK-DGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
             +     TW + D  V    P   R  +N S         L    +  +D GEY C   
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS---------LELKSVKFNDAGEYHCMVS 594

Query: 216 NGYGTPMTS 224
           +  G+   S
Sbjct: 595 SEGGSSAAS 603



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 33/124 (26%), Positives = 50/124 (40%), Gaps = 18/124 (14%)

Query: 99   VTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS--ATIGNRAVLTCSEQ 156
            V  +D G YTC+ S   G +     V + VL     PT+       +TI    V    + 
Sbjct: 950  VQLQDGGEYTCVASNVAGTNNKTTSVVVHVL-----PTIQHGQQILSTIEGIPVTLPCKA 1004

Query: 157  DGSPPSEYTWFKDG-IVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
             G+P     W K G ++  ++ K +     S YV++P             ++GEY C A 
Sbjct: 1005 SGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSP----------GGEESGEYVCTAT 1054

Query: 216  NGYG 219
            N  G
Sbjct: 1055 NTAG 1058


>gi|62865876 immunoglobulin superfamily, member 11 isoform b [Homo
           sapiens]
          Length = 431

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 70/267 (26%), Positives = 110/267 (41%), Gaps = 37/267 (13%)

Query: 19  ILLCSL--ALGSVTVHSSEPEVRIPENNPVKLSCAYS---GFSSPRVEWKF----DQGDT 69
           +LL SL     S+ V  S   +++    P  L C ++      +  V W      +    
Sbjct: 11  LLLLSLHGVAASLEVSESPGSIQVARGQPAVLPCTFTTSAALINLNVIWMVTPLSNANQP 70

Query: 70  TRLVCYNNKI----TASYEDRVTFLPT------GITFKSVTREDTGTYTCMVS---EEGG 116
            +++ Y           +  RV F  T       I   +    DTGTY C+V+   + GG
Sbjct: 71  EQVILYQGGQMFDGAPRFHGRVGFTGTMPATNVSIFINNTQLSDTGTYQCLVNNLPDIGG 130

Query: 117 NSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTN 176
            + G     L VLVPPS P   I  S  IG+  +L CS ++G P   Y W K    +   
Sbjct: 131 RNIGVTG--LTVLVPPSAPHCQIQGSQDIGSDVILLCSSEEGIPRPTYLWEKLDNTLKLP 188

Query: 177 PKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVE-RN 235
           P +T+         +   G +    +SA  +G Y C A N  GT      +++ + + RN
Sbjct: 189 PTATQ---------DQVQGTVTIRNISALSSGLYQCVASNAIGTSTCLLDLQVISPQPRN 239

Query: 236 VGVIVAAV---LVTLILLGILVFGIWF 259
           +G+I  A+    V +I    L+ G +F
Sbjct: 240 IGLIAGAIGTGAVIIIFCIALILGAFF 266


>gi|62865874 immunoglobulin superfamily, member 11 isoform a [Homo
           sapiens]
          Length = 430

 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 52/164 (31%), Positives = 78/164 (47%), Gaps = 18/164 (10%)

Query: 103 DTGTYTCMVS---EEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGS 159
           DTGTY C+V+   + GG + G     L VLVPPS P   I  S  IG+  +L CS ++G 
Sbjct: 113 DTGTYQCLVNNLPDIGGRNIGVTG--LTVLVPPSAPHCQIQGSQDIGSDVILLCSSEEGI 170

Query: 160 PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           P   Y W K    +   P +T+         +   G +    +SA  +G Y C A N  G
Sbjct: 171 PRPTYLWEKLDNTLKLPPTATQ---------DQVQGTVTIRNISALSSGLYQCVASNAIG 221

Query: 220 TPMTSNAVRMEAVE-RNVGVIVAAV---LVTLILLGILVFGIWF 259
           T      +++ + + RN+G+I  A+    V +I    L+ G +F
Sbjct: 222 TSTCLLDLQVISPQPRNIGLIAGAIGTGAVIIIFCIALILGAFF 265


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 60/211 (28%), Positives = 82/211 (38%), Gaps = 28/211 (13%)

Query: 15   FILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVC 74
            F L++LL    LG     S++ EV +  NNP+ L C    F SP + W  D         
Sbjct: 1247 FQLSVLLAPTILGGAE-DSADEEVTVTVNNPISLICEALAFPSPNITWMKD--------- 1296

Query: 75   YNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS- 133
                  AS   ++     G+   +  +ED G YTC+V+ E G +     V+  VL+PPS 
Sbjct: 1297 -GAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVE--VLIPPSI 1353

Query: 134  -----KPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSY 188
                    V +    T  N  +    E    PP    W+KDG   P  P S         
Sbjct: 1354 SKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDG--QPVTPSSRLQVLGEGR 1411

Query: 189  VLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            +L          P   SD+G Y C A N  G
Sbjct: 1412 LLQ-------IQPTQVSDSGRYLCVATNVAG 1435



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 54/183 (29%), Positives = 74/183 (40%), Gaps = 25/183 (13%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITF 96
            VR      V L C  SG   P + W+ +             +      +V  LP G +  
Sbjct: 2675 VRAVAEEEVLLPCEASGIPRPTITWQKE----------GLNVATGVSTQV--LPGGQLRI 2722

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQ 156
               + ED G Y C+     G++ G  K +L+V VPP         S T G+ A L C  +
Sbjct: 2723 AHASPEDAGNYLCIAKNSAGSAMG--KTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR 2780

Query: 157  DGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
             GSP    TW KDG      P S    +   + + P+ GEL+   L   D G Y+C A N
Sbjct: 2781 -GSPEPNITWDKDG-----QPVSG---AEGKFTIQPS-GELLVKNLEGQDAGTYTCTAEN 2830

Query: 217  GYG 219
              G
Sbjct: 2831 AVG 2833



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 57/203 (28%), Positives = 83/203 (40%), Gaps = 38/203 (18%)

Query: 33   SSEP-EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLP 91
            S +P E+ +    P++L C   G   P + W  D    TRL    N   A+   RV    
Sbjct: 2217 SGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRL---ENNSRATRVLRV---- 2269

Query: 92   TGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIV---LVPPSKPTVNIPSSATIGNR 148
                       D G YTC+     G      +V++     +V P  P   +  +     +
Sbjct: 2270 ----------RDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP---GQ 2316

Query: 149  AVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGE-LVFDPLSASDT 207
             VL CS +   P  + TW +DGIV+             ++   P  G  L    LS +D+
Sbjct: 2317 LVLECSVE-AEPAPKITWHRDGIVL----------QEDAHTQFPERGRFLQLQALSTADS 2365

Query: 208  GEYSCEARNGYGTPMTSNAVRME 230
            G+YSC ARN  G+  TS A R+E
Sbjct: 2366 GDYSCTARNAAGS--TSVAFRVE 2386



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 47/179 (26%), Positives = 70/179 (39%), Gaps = 24/179 (13%)

Query: 43  NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--ITFKSVT 100
           N PV+L+C  +G  SP + W  D           N ++ +    +   P G  +T  S  
Sbjct: 710 NTPVRLTCNATGAPSPTLMWLKD----------GNPVSPAGTPGLQVFPGGRVLTLASAR 759

Query: 101 REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSP 160
             D+G Y+C+     G    +V ++  V +PPS     +  S        L C +    P
Sbjct: 760 ASDSGRYSCVAVSAVGEDRQDVVLQ--VHMPPSILGEELNVSVVANESVALEC-QSHAMP 816

Query: 161 PSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           P   +W+KDG   P  P+     S    +L         D     D G Y+CEA N  G
Sbjct: 817 PPVLSWWKDG--RPLEPRPGVHLSADKALLQ-------VDRADVWDAGHYTCEALNQAG 866



 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 52/185 (28%), Positives = 72/185 (38%), Gaps = 34/185 (18%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK--SVT 100
            N+ V L C      +P V W            Y +    S  + V  LP   T +     
Sbjct: 1670 NSSVSLPCDVHAHPNPEVTW------------YKDSQALSLGEEVFLLPGTHTLQLGRAR 1717

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-KPTVNIPSSAT---IGNRAVLTCSEQ 156
              D+G YTC      G    +  V+L VLVPP+ +     P  A    +G++AVL+C E 
Sbjct: 1718 LSDSGMYTCEALNAAGRD--QKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC-ET 1774

Query: 157  DGSPPSEYTWFKDG--IVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
            D  P    TW+KDG  +V+    ++ R               L       SD G YSC+ 
Sbjct: 1775 DALPEPTVTWYKDGQPLVLAQRTQALRGGQ-----------RLEIQEAQVSDKGLYSCKV 1823

Query: 215  RNGYG 219
             N  G
Sbjct: 1824 SNVAG 1828



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 52/180 (28%), Positives = 74/180 (41%), Gaps = 23/180 (12%)

Query: 42  ENNPVKLSCAYSGFSSPRVEW-KFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVT 100
           EN  V L C  SG   P V W K  Q  ++ +      +T S + RV      +  +   
Sbjct: 617 ENASVTLECLASGVPPPDVSWFKGHQPVSSWM-----GVTVSVDGRV------LRIEQAQ 665

Query: 101 REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-KPTVNIPSSATIGNRAVLTCSEQDGS 159
             D G+Y C+ S   G++  E++  L V VPP      ++P    +     LTC+   G+
Sbjct: 666 LSDAGSYRCVASNVAGST--ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCN-ATGA 722

Query: 160 PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           P     W KDG   P +P  T         + P    L      ASD+G YSC A +  G
Sbjct: 723 PSPTLMWLKDG--NPVSPAGTPGLQ-----VFPGGRVLTLASARASDSGRYSCVAVSAVG 775



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 50/191 (26%), Positives = 70/191 (36%), Gaps = 22/191 (11%)

Query: 30   TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTF 89
            T+ S  P V +  N    L C   G  +P V W+ D+                   R   
Sbjct: 2392 TIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD-----------PRSPRFEI 2440

Query: 90   LPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNR 148
            LP G +  + V  +D G Y C+ S   G+        L VL PP+        + T    
Sbjct: 2441 LPEGSLRIQPVLAQDAGHYLCLASNSAGSD--RQGRDLRVLEPPAIAPSPSNLTLTAHTP 2498

Query: 149  AVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTG 208
            A+L C E  GSP     W+KDG       K        +Y L P+   L+  P    D+ 
Sbjct: 2499 ALLPC-EASGSPKPLVVWWKDG------QKLDFRLQQGAYRLLPSNALLLTAP-GPQDSA 2550

Query: 209  EYSCEARNGYG 219
            ++ C   N  G
Sbjct: 2551 QFECVVSNEVG 2561



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 54/220 (24%), Positives = 84/220 (38%), Gaps = 42/220 (19%)

Query: 40   IPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--ITFK 97
            I ENNP  L C  +    P + W            Y      S  D V+ L  G  +   
Sbjct: 1480 IVENNPAYLYCDTNAIPPPDLTW------------YREDQPLSAGDEVSVLQGGRVLQIP 1527

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP----------SKPTVNIPSSATIGN 147
             V  E+ G Y+C  S E G  +  +  +L+VL PP           + TVN  S+ ++  
Sbjct: 1528 LVRAENAGRYSCKASNEVGEDW--LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC 1585

Query: 148  RAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDT 207
             A+       G+P    +W ++G  +P +P           VL  +T E+       +D 
Sbjct: 1586 PAL-------GNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEV-------ADA 1629

Query: 208  GEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTL 247
              Y C A N  G+      +R++   R  G+ +  V   L
Sbjct: 1630 ASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAIL 1669



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 46/176 (26%), Positives = 66/176 (37%), Gaps = 18/176 (10%)

Query: 44   NPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRED 103
            +P+ L+C  SG  +P V W  D+            + +S    V      +    +    
Sbjct: 1858 SPLVLTCDVSGVPAPTVTWLKDR----------MPVESSAVHGVVSRGGRLQLSRLQPAQ 1907

Query: 104  TGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
             GTYTC+       +  +  V ++V        V        G    L C E DG PP +
Sbjct: 1908 AGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC-EADGQPPPD 1966

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              W KDG     +P       +  + L+   G LV   L ASD G Y+C A N  G
Sbjct: 1967 VAWLKDG-----SPLGQDMGPHLRFYLD--GGSLVLKGLRASDAGAYTCVAHNPAG 2015



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 43/184 (23%), Positives = 78/184 (42%), Gaps = 26/184 (14%)

Query: 48   LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
            L C+     +P++ W  D       +         + +R  FL      ++++  D+G Y
Sbjct: 2319 LECSVEAEPAPKITWHRDG------IVLQEDAHTQFPERGRFLQ----LQALSTADSGDY 2368

Query: 108  TCMVSEEGGNSYGEVKVKL--IVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYT 165
            +C      G++    +V++  +  +    P VN+    ++   A+L C + DG P    +
Sbjct: 2369 SCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNV----SVNQTALLPC-QADGVPAPLVS 2423

Query: 166  WFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSN 225
            W KD +  P +P+S R      + + P  G L   P+ A D G Y C A N  G+     
Sbjct: 2424 WRKDRV--PLDPRSPR------FEILPE-GSLRIQPVLAQDAGHYLCLASNSAGSDRQGR 2474

Query: 226  AVRM 229
             +R+
Sbjct: 2475 DLRV 2478



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 50/186 (26%), Positives = 72/186 (38%), Gaps = 27/186 (14%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            EV +  ++ V L C   G   P + W              N +  S   R+  L  G   
Sbjct: 1572 EVTVNASSTVSLQCPALGNPVPTISW------------LQNGLPFSPSPRLQVLEDGQVL 1619

Query: 97   KSVTRE--DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCS 154
            +  T E  D  +Y C+   + G++  E    L V VPP    +++     I N +V    
Sbjct: 1620 QVSTAEVADAASYMCVAENQAGSA--EKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPC 1677

Query: 155  EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYV-LNPTTGELVFDPLSASDTGEYSCE 213
            +    P  E TW+KD          ++A S    V L P T  L       SD+G Y+CE
Sbjct: 1678 DVHAHPNPEVTWYKD----------SQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 1727

Query: 214  ARNGYG 219
            A N  G
Sbjct: 1728 ALNAAG 1733



 Score = 51.6 bits (122), Expect = 8e-07
 Identities = 48/181 (26%), Positives = 67/181 (37%), Gaps = 28/181 (15%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK--SVT 100
            ++P+ L C   G   P + W            +  +   S  +    L  G   K     
Sbjct: 1085 HSPLTLLCEAMGIPPPAIRW------------FRGEEPVSPGEDTYLLAGGWMLKMTQTQ 1132

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI--GNRAVLTCSEQDG 158
             +D+G Y+C+ S E G +     V+  VLVPPS    ++     +  G  A L C+   G
Sbjct: 1133 EQDSGLYSCLASNEAGEARRNFSVE--VLVPPSIENEDLEEVIKVLDGQTAHLMCN-VTG 1189

Query: 159  SPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGY 218
             P  + TWFKDG   P         S    +L      L       S  G YSC A N  
Sbjct: 1190 HPQPKLTWFKDG--RPLARGDAHHISPDGVLLQVLQANL-------SSAGHYSCIAANAV 1240

Query: 219  G 219
            G
Sbjct: 1241 G 1241



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 48/175 (27%), Positives = 68/175 (38%), Gaps = 21/175 (12%)

Query: 46  VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
           V+L C  SG  +P+VEW  D+    + V          ED      TG         D G
Sbjct: 144 VELQCWTSGVPTPQVEWTKDR----QPVLPGGPHLQVQEDGQVLRITGSHVG-----DEG 194

Query: 106 TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS-ATIGNRAVLTCSEQDGSPPSEY 164
            Y C+     G    + +++  V  PP+    N     A + +  V    E  G P    
Sbjct: 195 RYQCVAFSPAGQQARDFQLR--VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 252

Query: 165 TWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           TWFKDG ++PT+ K          V      +L      +SD G Y+C+A N  G
Sbjct: 253 TWFKDGALLPTSTK---------VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 298



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 46/184 (25%), Positives = 71/184 (38%), Gaps = 31/184 (16%)

Query: 40   IPENNPVKLSCAYSGFSSPRVEWKFD----QGDTTRLVCYNNKITASYEDRVTFLPTGIT 95
            + E +P +LSC   G   P++ W+ D     G+   L              V+ +   + 
Sbjct: 892  VREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGL------------QHVSAVGRLLY 939

Query: 96   FKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIV---LVPPSKPTVNIPSSATIGNRAVLT 152
                     GTYTC  S   GNS  ++++++ V   +  P +P   +  S      A L 
Sbjct: 940  LGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV--SVVQDGVATLE 997

Query: 153  CSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSC 212
            C+   G PP   TW +DG   P   +      N    L+        +   A+ TG YSC
Sbjct: 998  CN-ATGKPPPTVTWERDG--QPVGAELGLQLQNQGQSLH-------VERAQAAHTGRYSC 1047

Query: 213  EARN 216
             A N
Sbjct: 1048 VAEN 1051



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 42/145 (28%), Positives = 58/145 (40%), Gaps = 12/145 (8%)

Query: 90  LPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRA 149
           LP  +  + V   D G YTC  +   G S  EV +K  VLVPP+     + + A + N +
Sbjct: 564 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK--VLVPPNIEPGPV-NKAVLENAS 620

Query: 150 VLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGE 209
           V       G PP + +WFK     P +       S    VL     +L       SD G 
Sbjct: 621 VTLECLASGVPPPDVSWFKGH--QPVSSWMGVTVSVDGRVLRIEQAQL-------SDAGS 671

Query: 210 YSCEARNGYGTPMTSNAVRMEAVER 234
           Y C A N  G+      +R+    R
Sbjct: 672 YRCVASNVAGSTELRYGLRVNVPPR 696



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 38/245 (15%)

Query: 15   FILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVC 74
            F++A+L+      S        E  + E   V+L C   G   P V W  D         
Sbjct: 1926 FVVAVLVAPRIRSSGVAR----EHHVLEGQEVRLDCEADGQPPPDVAWLKD--------- 1972

Query: 75   YNNKITASYEDRVTFLPTG--ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP 132
              + +       + F   G  +  K +   D G YTC+     G       V   VLVPP
Sbjct: 1973 -GSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVN--VLVPP 2029

Query: 133  SKPTVNIPSSATI---GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYV 189
            +       S   +   G    + C  + GSPP   +W KDG+ +P + ++         +
Sbjct: 2030 TIKQGADGSGTLVSRPGELVTMVCPVR-GSPPIHVSWLKDGLPLPLSQRT---------L 2079

Query: 190  LNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVR------MEAVE-RNVGVIVAA 242
            L+ +   L    +  +D G ++C A +  G    +  ++      +E VE +N  V+V  
Sbjct: 2080 LHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRG 2139

Query: 243  VLVTL 247
             LV L
Sbjct: 2140 SLVEL 2144



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 47/201 (23%), Positives = 77/201 (38%), Gaps = 26/201 (12%)

Query: 31   VHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFL 90
            + +  P++   E +   L C   G   P + W  D            +  +  E + T  
Sbjct: 2758 IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKD-----------GQPVSGAEGKFTIQ 2806

Query: 91   PTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRA 149
            P+G +  K++  +D GTYTC      G +    +V L +LV P   T+    S  +G+R 
Sbjct: 2807 PSGELLVKNLEGQDAGTYTCTAENAVGRA--RRRVHLTILVLPVFTTLPGDRSLRLGDRL 2864

Query: 150  VLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGE 209
             L C+ + GSP     W  +    P     +     S+         L    +S  D+G 
Sbjct: 2865 WLRCAAR-GSPTPRIGWTVND--RPVTEGVSEQDGGST---------LQRAAVSREDSGT 2912

Query: 210  YSCEARNGYGTPMTSNAVRME 230
            Y C A N  G     + V ++
Sbjct: 2913 YVCWAENRVGRTQAVSFVHVK 2933



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 53/203 (26%), Positives = 79/203 (38%), Gaps = 35/203 (17%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            +V +   + V+L C   G   P V W  D G+          ++ S E   +     +  
Sbjct: 2133 DVVVVRGSLVELPCEARGVPLPLVSWMKD-GEPL--------LSQSLEQGPS-----LQL 2178

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPS--SATIGNRAVLTCS 154
            ++V   D+GTY+C+   E G +      +L V+ PP       P+  S T G    L C 
Sbjct: 2179 EAVGAGDSGTYSCVAVSEAGEA--RRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD 2236

Query: 155  EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
             Q G+P    TW KDG  +     ++RA                   L   D G Y+C A
Sbjct: 2237 AQ-GTPQPNITWHKDGQALTRLENNSRATR----------------VLRVRDAGLYTCLA 2279

Query: 215  RNGYGTPMTSNAVRMEAVERNVG 237
             +  G    S  VR++A    VG
Sbjct: 2280 ESPAGAIEKSFRVRVQAPPNIVG 2302



 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 44/187 (23%), Positives = 66/187 (35%), Gaps = 38/187 (20%)

Query: 41   PENNPVKLSCAYSGFSSPRVEWKFD----QGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            P    ++L C   G   P + W  D    +G   R    N  +T                
Sbjct: 2949 PVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLT---------------I 2993

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNI-PSSATI--GNRAVLTC 153
            +   R+D G Y C+   E G     V  K+++LV  S P   + P   T+  G+   L C
Sbjct: 2994 RRTERDDAGRYQCLAENEMG-----VAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRC 3048

Query: 154  SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCE 213
             +  G P     W + G  +  + +       S ++ N  TG          D G Y C 
Sbjct: 3049 -QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG----------DAGTYDCV 3097

Query: 214  ARNGYGT 220
            A N  G+
Sbjct: 3098 AHNLLGS 3104



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 35/118 (29%), Positives = 48/118 (40%), Gaps = 19/118 (16%)

Query: 103  DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI----GNRAVLTCSEQDG 158
            D G Y+C VS   G +     V+   L     PT   P + T+    G+  VLTC +  G
Sbjct: 1815 DKGLYSCKVSNVAGEA-----VRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTC-DVSG 1868

Query: 159  SPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
             P    TW KD   MP         S++ + +    G L    L  +  G Y+C A N
Sbjct: 1869 VPAPTVTWLKDR--MPVE-------SSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 1917



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 42/185 (22%), Positives = 67/185 (36%), Gaps = 24/185 (12%)

Query: 38  VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
           V+     PV L C   G  SP + W  +             +  S E R+    + +  +
Sbjct: 324 VKAVAGRPVALECVARGHPSPTLSWHHE----------GLPVAESNESRLETDGSVLRLE 373

Query: 98  SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSAT--IGNRAVLTCSE 155
           S     +G Y+C+ S   G +  +  V+  V VPP           T  +G    L C +
Sbjct: 374 SPGEASSGLYSCVASSPAGEAVLQYSVE--VQVPPQLLVAEGLGQVTTIVGQPLELPC-Q 430

Query: 156 QDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
             GSP     W ++G       +     +        TT  L  D +    +G ++C+A 
Sbjct: 431 ASGSPVPTIQWLQNG-------RPAEELAGVQVASQGTT--LHIDHVELDHSGLFACQAT 481

Query: 216 NGYGT 220
           N  GT
Sbjct: 482 NEAGT 486



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 46/188 (24%), Positives = 70/188 (37%), Gaps = 29/188 (15%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            +V + ++    L C  +G   P V W+ D             + A    ++      +  
Sbjct: 985  QVSVVQDGVATLECNATGKPPPTVTWERD----------GQPVGAELGLQLQNQGQSLHV 1034

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-----KPTVNIPSSATIGNRAVL 151
            +      TG Y+C+     G +  E K +L VLVPP       P  NI  +A + +   L
Sbjct: 1035 ERAQAAHTGRYSCVAENLAGRA--ERKFELSVLVPPELIGDLDPLTNI--TAALHSPLTL 1090

Query: 152  TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
             C E  G PP    WF+     P +P          ++L  T  +         D+G YS
Sbjct: 1091 LC-EAMGIPPPAIRWFRG--EEPVSPGEDTYLLAGGWMLKMTQTQ-------EQDSGLYS 1140

Query: 212  CEARNGYG 219
            C A N  G
Sbjct: 1141 CLASNEAG 1148



 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 49/200 (24%), Positives = 82/200 (41%), Gaps = 31/200 (15%)

Query: 37  EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
           EV + E++ V+L C   G  +P + W F  G    L+  + K+  +   R       +  
Sbjct: 229 EVAVMEDHLVQLLCEARGVPTPNITW-FKDG---ALLPTSTKVVYTRGGR------QLQL 278

Query: 97  KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS------KPTVNIPSSATIGNRAV 150
                 D G YTC  S   G +  E   +L V VPP+      +P V     A  G    
Sbjct: 279 GRAQSSDAGVYTCKASNAVGAA--EKATRLDVYVPPTIEGAGGRPYV---VKAVAGRPVA 333

Query: 151 LTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEY 210
           L C  + G P    +W  +G+ +  + +S R  ++ S +   + GE        + +G Y
Sbjct: 334 LECVAR-GHPSPTLSWHHEGLPVAESNES-RLETDGSVLRLESPGE--------ASSGLY 383

Query: 211 SCEARNGYGTPMTSNAVRME 230
           SC A +  G  +   +V ++
Sbjct: 384 SCVASSPAGEAVLQYSVEVQ 403



 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 49/199 (24%), Positives = 73/199 (36%), Gaps = 35/199 (17%)

Query: 30   TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVT- 88
            T+   + +  +    PV L+C  +G  +P V W              +K  A    R + 
Sbjct: 2576 TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW--------------SKAGAQLGARGSG 2621

Query: 89   --FLPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVN-IPSSA- 143
                P+G +          G YTC      G ++     K + L   + P V  +PS   
Sbjct: 2622 YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-----KHVFLTVQASPVVKPLPSVVR 2676

Query: 144  TIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLS 203
             +    VL   E  G P    TW K+G+ + T          S+ VL    G+L     S
Sbjct: 2677 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGV--------STQVL--PGGQLRIAHAS 2726

Query: 204  ASDTGEYSCEARNGYGTPM 222
              D G Y C A+N  G+ M
Sbjct: 2727 PEDAGNYLCIAKNSAGSAM 2745



 Score = 35.4 bits (80), Expect = 0.061
 Identities = 37/197 (18%), Positives = 68/197 (34%), Gaps = 27/197 (13%)

Query: 28   SVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRV 87
            S+     E  +++ +     L C  +G   P++ W  D     R             D  
Sbjct: 1163 SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR------------GDAH 1210

Query: 88   TFLPTGITFK--SVTREDTGTYTCMVSEEGGNSYGEVKVKLIV---LVPPSKPTVNIPSS 142
               P G+  +         G Y+C+ +   G      ++ +++   ++  ++ + +   +
Sbjct: 1211 HISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVT 1270

Query: 143  ATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPL 202
             T+ N   L C E    P    TW KDG             ++ +  L P T  L     
Sbjct: 1271 VTVNNPISLIC-EALAFPSPNITWMKDGAPFE---------ASRNIQLLPGTHGLQILNA 1320

Query: 203  SASDTGEYSCEARNGYG 219
               D G+Y+C   N  G
Sbjct: 1321 QKEDAGQYTCVVTNELG 1337



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 25/89 (28%), Positives = 37/89 (41%), Gaps = 14/89 (15%)

Query: 24   LALGSVTVHSSEPE-VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITAS 82
            L L S  V   EP+ + +   + V L C  +G  +P +EW    G   R           
Sbjct: 3021 LVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRA---------- 3069

Query: 83   YEDRVTFLPTG-ITFKSVTREDTGTYTCM 110
               R+  LP G +  ++V   D GTY C+
Sbjct: 3070 -SRRLRTLPDGSLWLENVETGDAGTYDCV 3097



 Score = 29.6 bits (65), Expect = 3.4
 Identities = 45/192 (23%), Positives = 62/192 (32%), Gaps = 20/192 (10%)

Query: 48  LSCAYSGFSSPRVEWKFDQ---GDTTRLVCYNNKITASYEDRVTFLPTG--ITFKSVTRE 102
           L C  +GF  P + W  D    G       Y   +          L  G  + F  +   
Sbjct: 38  LECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEG 97

Query: 103 DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS--ATIGNRAVLTCSEQDGSP 160
           D+G Y+C    + G +  +    L+VL PPS              G    L C    G P
Sbjct: 98  DSGLYSCRAENQAGTAQRD--FHLLVLTPPSVLGAGAAQEVLGLAGADVELQC-WTSGVP 154

Query: 161 PSEYTWFKD-GIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
             +  W KD   V+P  P           VL  T   +        D G Y C A +  G
Sbjct: 155 TPQVEWTKDRQPVLPGGPH--LQVQEDGQVLRITGSHV-------GDEGRYQCVAFSPAG 205

Query: 220 TPMTSNAVRMEA 231
                  +R+ A
Sbjct: 206 QQARDFQLRVHA 217


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 60/211 (28%), Positives = 82/211 (38%), Gaps = 28/211 (13%)

Query: 15   FILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVC 74
            F L++LL    LG     S++ EV +  NNP+ L C    F SP + W  D         
Sbjct: 1338 FQLSVLLAPTILGGAE-DSADEEVTVTVNNPISLICEALAFPSPNITWMKD--------- 1387

Query: 75   YNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS- 133
                  AS   ++     G+   +  +ED G YTC+V+ E G +     V+  VL+PPS 
Sbjct: 1388 -GAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVE--VLIPPSI 1444

Query: 134  -----KPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSY 188
                    V +    T  N  +    E    PP    W+KDG   P  P S         
Sbjct: 1445 SKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDG--QPVTPSSRLQVLGEGR 1502

Query: 189  VLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            +L          P   SD+G Y C A N  G
Sbjct: 1503 LLQ-------IQPTQVSDSGRYLCVATNVAG 1526



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 54/183 (29%), Positives = 74/183 (40%), Gaps = 25/183 (13%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITF 96
            VR      V L C  SG   P + W+ +             +      +V  LP G +  
Sbjct: 2766 VRAVAEEEVLLPCEASGIPRPTITWQKE----------GLNVATGVSTQV--LPGGQLRI 2813

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQ 156
               + ED G Y C+     G++ G  K +L+V VPP         S T G+ A L C  +
Sbjct: 2814 AHASPEDAGNYLCIAKNSAGSAMG--KTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR 2871

Query: 157  DGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
             GSP    TW KDG      P S    +   + + P+ GEL+   L   D G Y+C A N
Sbjct: 2872 -GSPEPNITWDKDG-----QPVSG---AEGKFTIQPS-GELLVKNLEGQDAGTYTCTAEN 2921

Query: 217  GYG 219
              G
Sbjct: 2922 AVG 2924



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 57/203 (28%), Positives = 83/203 (40%), Gaps = 38/203 (18%)

Query: 33   SSEP-EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLP 91
            S +P E+ +    P++L C   G   P + W  D    TRL    N   A+   RV    
Sbjct: 2308 SGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRL---ENNSRATRVLRV---- 2360

Query: 92   TGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIV---LVPPSKPTVNIPSSATIGNR 148
                       D G YTC+     G      +V++     +V P  P   +  +     +
Sbjct: 2361 ----------RDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP---GQ 2407

Query: 149  AVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGE-LVFDPLSASDT 207
             VL CS +   P  + TW +DGIV+             ++   P  G  L    LS +D+
Sbjct: 2408 LVLECSVE-AEPAPKITWHRDGIVL----------QEDAHTQFPERGRFLQLQALSTADS 2456

Query: 208  GEYSCEARNGYGTPMTSNAVRME 230
            G+YSC ARN  G+  TS A R+E
Sbjct: 2457 GDYSCTARNAAGS--TSVAFRVE 2477



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 47/179 (26%), Positives = 70/179 (39%), Gaps = 24/179 (13%)

Query: 43  NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--ITFKSVT 100
           N PV+L+C  +G  SP + W  D           N ++ +    +   P G  +T  S  
Sbjct: 801 NTPVRLTCNATGAPSPTLMWLKD----------GNPVSPAGTPGLQVFPGGRVLTLASAR 850

Query: 101 REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSP 160
             D+G Y+C+     G    +V ++  V +PPS     +  S        L C +    P
Sbjct: 851 ASDSGRYSCVAVSAVGEDRQDVVLQ--VHMPPSILGEELNVSVVANESVALEC-QSHAMP 907

Query: 161 PSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           P   +W+KDG   P  P+     S    +L         D     D G Y+CEA N  G
Sbjct: 908 PPVLSWWKDG--RPLEPRPGVHLSADKALLQ-------VDRADVWDAGHYTCEALNQAG 957



 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 52/185 (28%), Positives = 72/185 (38%), Gaps = 34/185 (18%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK--SVT 100
            N+ V L C      +P V W            Y +    S  + V  LP   T +     
Sbjct: 1761 NSSVSLPCDVHAHPNPEVTW------------YKDSQALSLGEEVFLLPGTHTLQLGRAR 1808

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-KPTVNIPSSAT---IGNRAVLTCSEQ 156
              D+G YTC      G    +  V+L VLVPP+ +     P  A    +G++AVL+C E 
Sbjct: 1809 LSDSGMYTCEALNAAGRD--QKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC-ET 1865

Query: 157  DGSPPSEYTWFKDG--IVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
            D  P    TW+KDG  +V+    ++ R               L       SD G YSC+ 
Sbjct: 1866 DALPEPTVTWYKDGQPLVLAQRTQALRGGQ-----------RLEIQEAQVSDKGLYSCKV 1914

Query: 215  RNGYG 219
             N  G
Sbjct: 1915 SNVAG 1919



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 52/180 (28%), Positives = 74/180 (41%), Gaps = 23/180 (12%)

Query: 42  ENNPVKLSCAYSGFSSPRVEW-KFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVT 100
           EN  V L C  SG   P V W K  Q  ++ +      +T S + RV      +  +   
Sbjct: 708 ENASVTLECLASGVPPPDVSWFKGHQPVSSWM-----GVTVSVDGRV------LRIEQAQ 756

Query: 101 REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-KPTVNIPSSATIGNRAVLTCSEQDGS 159
             D G+Y C+ S   G++  E++  L V VPP      ++P    +     LTC+   G+
Sbjct: 757 LSDAGSYRCVASNVAGST--ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCN-ATGA 813

Query: 160 PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           P     W KDG   P +P  T         + P    L      ASD+G YSC A +  G
Sbjct: 814 PSPTLMWLKDG--NPVSPAGTPGLQ-----VFPGGRVLTLASARASDSGRYSCVAVSAVG 866



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 50/191 (26%), Positives = 70/191 (36%), Gaps = 22/191 (11%)

Query: 30   TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTF 89
            T+ S  P V +  N    L C   G  +P V W+ D+                   R   
Sbjct: 2483 TIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD-----------PRSPRFEI 2531

Query: 90   LPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNR 148
            LP G +  + V  +D G Y C+ S   G+        L VL PP+        + T    
Sbjct: 2532 LPEGSLRIQPVLAQDAGHYLCLASNSAGSD--RQGRDLRVLEPPAIAPSPSNLTLTAHTP 2589

Query: 149  AVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTG 208
            A+L C E  GSP     W+KDG       K        +Y L P+   L+  P    D+ 
Sbjct: 2590 ALLPC-EASGSPKPLVVWWKDG------QKLDFRLQQGAYRLLPSNALLLTAP-GPQDSA 2641

Query: 209  EYSCEARNGYG 219
            ++ C   N  G
Sbjct: 2642 QFECVVSNEVG 2652



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 54/220 (24%), Positives = 84/220 (38%), Gaps = 42/220 (19%)

Query: 40   IPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--ITFK 97
            I ENNP  L C  +    P + W            Y      S  D V+ L  G  +   
Sbjct: 1571 IVENNPAYLYCDTNAIPPPDLTW------------YREDQPLSAGDEVSVLQGGRVLQIP 1618

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP----------SKPTVNIPSSATIGN 147
             V  E+ G Y+C  S E G  +  +  +L+VL PP           + TVN  S+ ++  
Sbjct: 1619 LVRAENAGRYSCKASNEVGEDW--LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC 1676

Query: 148  RAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDT 207
             A+       G+P    +W ++G  +P +P           VL  +T E+       +D 
Sbjct: 1677 PAL-------GNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEV-------ADA 1720

Query: 208  GEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTL 247
              Y C A N  G+      +R++   R  G+ +  V   L
Sbjct: 1721 ASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAIL 1760



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 46/176 (26%), Positives = 66/176 (37%), Gaps = 18/176 (10%)

Query: 44   NPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRED 103
            +P+ L+C  SG  +P V W  D+            + +S    V      +    +    
Sbjct: 1949 SPLVLTCDVSGVPAPTVTWLKDR----------MPVESSAVHGVVSRGGRLQLSRLQPAQ 1998

Query: 104  TGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
             GTYTC+       +  +  V ++V        V        G    L C E DG PP +
Sbjct: 1999 AGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC-EADGQPPPD 2057

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              W KDG     +P       +  + L+   G LV   L ASD G Y+C A N  G
Sbjct: 2058 VAWLKDG-----SPLGQDMGPHLRFYLD--GGSLVLKGLRASDAGAYTCVAHNPAG 2106



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 43/184 (23%), Positives = 78/184 (42%), Gaps = 26/184 (14%)

Query: 48   LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
            L C+     +P++ W  D       +         + +R  FL      ++++  D+G Y
Sbjct: 2410 LECSVEAEPAPKITWHRDG------IVLQEDAHTQFPERGRFLQ----LQALSTADSGDY 2459

Query: 108  TCMVSEEGGNSYGEVKVKL--IVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYT 165
            +C      G++    +V++  +  +    P VN+    ++   A+L C + DG P    +
Sbjct: 2460 SCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNV----SVNQTALLPC-QADGVPAPLVS 2514

Query: 166  WFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSN 225
            W KD +  P +P+S R      + + P  G L   P+ A D G Y C A N  G+     
Sbjct: 2515 WRKDRV--PLDPRSPR------FEILPE-GSLRIQPVLAQDAGHYLCLASNSAGSDRQGR 2565

Query: 226  AVRM 229
             +R+
Sbjct: 2566 DLRV 2569



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 50/186 (26%), Positives = 72/186 (38%), Gaps = 27/186 (14%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            EV +  ++ V L C   G   P + W              N +  S   R+  L  G   
Sbjct: 1663 EVTVNASSTVSLQCPALGNPVPTISW------------LQNGLPFSPSPRLQVLEDGQVL 1710

Query: 97   KSVTRE--DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCS 154
            +  T E  D  +Y C+   + G++  E    L V VPP    +++     I N +V    
Sbjct: 1711 QVSTAEVADAASYMCVAENQAGSA--EKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPC 1768

Query: 155  EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYV-LNPTTGELVFDPLSASDTGEYSCE 213
            +    P  E TW+KD          ++A S    V L P T  L       SD+G Y+CE
Sbjct: 1769 DVHAHPNPEVTWYKD----------SQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 1818

Query: 214  ARNGYG 219
            A N  G
Sbjct: 1819 ALNAAG 1824



 Score = 51.6 bits (122), Expect = 8e-07
 Identities = 48/181 (26%), Positives = 67/181 (37%), Gaps = 28/181 (15%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK--SVT 100
            ++P+ L C   G   P + W            +  +   S  +    L  G   K     
Sbjct: 1176 HSPLTLLCEAMGIPPPAIRW------------FRGEEPVSPGEDTYLLAGGWMLKMTQTQ 1223

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI--GNRAVLTCSEQDG 158
             +D+G Y+C+ S E G +     V+  VLVPPS    ++     +  G  A L C+   G
Sbjct: 1224 EQDSGLYSCLASNEAGEARRNFSVE--VLVPPSIENEDLEEVIKVLDGQTAHLMCN-VTG 1280

Query: 159  SPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGY 218
             P  + TWFKDG   P         S    +L      L       S  G YSC A N  
Sbjct: 1281 HPQPKLTWFKDG--RPLARGDAHHISPDGVLLQVLQANL-------SSAGHYSCIAANAV 1331

Query: 219  G 219
            G
Sbjct: 1332 G 1332



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 48/175 (27%), Positives = 68/175 (38%), Gaps = 21/175 (12%)

Query: 46  VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
           V+L C  SG  +P+VEW  D+    + V          ED      TG         D G
Sbjct: 235 VELQCWTSGVPTPQVEWTKDR----QPVLPGGPHLQVQEDGQVLRITGSHVG-----DEG 285

Query: 106 TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS-ATIGNRAVLTCSEQDGSPPSEY 164
            Y C+     G    + +++  V  PP+    N     A + +  V    E  G P    
Sbjct: 286 RYQCVAFSPAGQQARDFQLR--VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 343

Query: 165 TWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           TWFKDG ++PT+ K          V      +L      +SD G Y+C+A N  G
Sbjct: 344 TWFKDGALLPTSTK---------VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 389



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 46/184 (25%), Positives = 70/184 (38%), Gaps = 31/184 (16%)

Query: 40   IPENNPVKLSCAYSGFSSPRVEWKFD----QGDTTRLVCYNNKITASYEDRVTFLPTGIT 95
            + E +P  LSC   G   P++ W+ D     G+   L              V+ +   + 
Sbjct: 983  VREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGL------------QHVSAVGRLLY 1030

Query: 96   FKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIV---LVPPSKPTVNIPSSATIGNRAVLT 152
                     GTYTC  S   GNS  ++++++ V   +  P +P   +  S      A L 
Sbjct: 1031 LGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV--SVVQDGVATLE 1088

Query: 153  CSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSC 212
            C+   G PP   TW +DG   P   +      N    L+        +   A+ TG YSC
Sbjct: 1089 CN-ATGKPPPTVTWERDG--QPVGAELGLQLQNQGQSLH-------VERAQAAHTGRYSC 1138

Query: 213  EARN 216
             A N
Sbjct: 1139 VAEN 1142



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 42/145 (28%), Positives = 58/145 (40%), Gaps = 12/145 (8%)

Query: 90  LPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRA 149
           LP  +  + V   D G YTC  +   G S  EV +K  VLVPP+     + + A + N +
Sbjct: 655 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK--VLVPPNIEPGPV-NKAVLENAS 711

Query: 150 VLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGE 209
           V       G PP + +WFK     P +       S    VL     +L       SD G 
Sbjct: 712 VTLECLASGVPPPDVSWFKGH--QPVSSWMGVTVSVDGRVLRIEQAQL-------SDAGS 762

Query: 210 YSCEARNGYGTPMTSNAVRMEAVER 234
           Y C A N  G+      +R+    R
Sbjct: 763 YRCVASNVAGSTELRYGLRVNVPPR 787



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 38/245 (15%)

Query: 15   FILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVC 74
            F++A+L+      S        E  + E   V+L C   G   P V W  D         
Sbjct: 2017 FVVAVLVAPRIRSSGVAR----EHHVLEGQEVRLDCEADGQPPPDVAWLKD--------- 2063

Query: 75   YNNKITASYEDRVTFLPTG--ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP 132
              + +       + F   G  +  K +   D G YTC+     G       V   VLVPP
Sbjct: 2064 -GSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVN--VLVPP 2120

Query: 133  SKPTVNIPSSATI---GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYV 189
            +       S   +   G    + C  + GSPP   +W KDG+ +P + ++         +
Sbjct: 2121 TIKQGADGSGTLVSRPGELVTMVCPVR-GSPPIHVSWLKDGLPLPLSQRT---------L 2170

Query: 190  LNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVR------MEAVE-RNVGVIVAA 242
            L+ +   L    +  +D G ++C A +  G    +  ++      +E VE +N  V+V  
Sbjct: 2171 LHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRG 2230

Query: 243  VLVTL 247
             LV L
Sbjct: 2231 SLVEL 2235



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 47/201 (23%), Positives = 77/201 (38%), Gaps = 26/201 (12%)

Query: 31   VHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFL 90
            + +  P++   E +   L C   G   P + W  D            +  +  E + T  
Sbjct: 2849 IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKD-----------GQPVSGAEGKFTIQ 2897

Query: 91   PTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRA 149
            P+G +  K++  +D GTYTC      G +    +V L +LV P   T+    S  +G+R 
Sbjct: 2898 PSGELLVKNLEGQDAGTYTCTAENAVGRA--RRRVHLTILVLPVFTTLPGDRSLRLGDRL 2955

Query: 150  VLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGE 209
             L C+ + GSP     W  +    P     +     S+         L    +S  D+G 
Sbjct: 2956 WLRCAAR-GSPTPRIGWTVND--RPVTEGVSEQDGGST---------LQRAAVSREDSGT 3003

Query: 210  YSCEARNGYGTPMTSNAVRME 230
            Y C A N  G     + V ++
Sbjct: 3004 YVCWAENRVGRTQAVSFVHVK 3024



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 53/203 (26%), Positives = 79/203 (38%), Gaps = 35/203 (17%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            +V +   + V+L C   G   P V W  D G+          ++ S E   +     +  
Sbjct: 2224 DVVVVRGSLVELPCEARGVPLPLVSWMKD-GEPL--------LSQSLEQGPS-----LQL 2269

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPS--SATIGNRAVLTCS 154
            ++V   D+GTY+C+   E G +      +L V+ PP       P+  S T G    L C 
Sbjct: 2270 EAVGAGDSGTYSCVAVSEAGEA--RRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD 2327

Query: 155  EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
             Q G+P    TW KDG  +     ++RA                   L   D G Y+C A
Sbjct: 2328 AQ-GTPQPNITWHKDGQALTRLENNSRATR----------------VLRVRDAGLYTCLA 2370

Query: 215  RNGYGTPMTSNAVRMEAVERNVG 237
             +  G    S  VR++A    VG
Sbjct: 2371 ESPAGAIEKSFRVRVQAPPNIVG 2393



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 44/187 (23%), Positives = 66/187 (35%), Gaps = 38/187 (20%)

Query: 41   PENNPVKLSCAYSGFSSPRVEWKFD----QGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            P    ++L C   G   P + W  D    +G   R    N  +T    +R          
Sbjct: 3040 PVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTER---------- 3089

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNI-PSSATI--GNRAVLTC 153
                 +D G Y C+   E G     V  K+++LV  S P   + P   T+  G+   L C
Sbjct: 3090 -----DDAGRYQCLAENEMG-----VAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRC 3139

Query: 154  SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCE 213
             +  G P     W + G  +  + +       S ++ N  TG          D G Y C 
Sbjct: 3140 -QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG----------DAGTYDCV 3188

Query: 214  ARNGYGT 220
            A N  G+
Sbjct: 3189 AHNLLGS 3195



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 35/118 (29%), Positives = 48/118 (40%), Gaps = 19/118 (16%)

Query: 103  DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI----GNRAVLTCSEQDG 158
            D G Y+C VS   G +     V+   L     PT   P + T+    G+  VLTC +  G
Sbjct: 1906 DKGLYSCKVSNVAGEA-----VRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTC-DVSG 1959

Query: 159  SPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
             P    TW KD   MP         S++ + +    G L    L  +  G Y+C A N
Sbjct: 1960 VPAPTVTWLKDR--MPVE-------SSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 2008



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 42/185 (22%), Positives = 67/185 (36%), Gaps = 24/185 (12%)

Query: 38  VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
           V+     PV L C   G  SP + W  +             +  S E R+    + +  +
Sbjct: 415 VKAVAGRPVALECVARGHPSPTLSWHHE----------GLPVAESNESRLETDGSVLRLE 464

Query: 98  SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSAT--IGNRAVLTCSE 155
           S     +G Y+C+ S   G +  +  V+  V VPP           T  +G    L C +
Sbjct: 465 SPGEASSGLYSCVASSPAGEAVLQYSVE--VQVPPQLLVAEGLGQVTTIVGQPLELPC-Q 521

Query: 156 QDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
             GSP     W ++G       +     +        TT  L  D +    +G ++C+A 
Sbjct: 522 ASGSPVPTIQWLQNG-------RPAEELAGVQVASQGTT--LHIDHVELDHSGLFACQAT 572

Query: 216 NGYGT 220
           N  GT
Sbjct: 573 NEAGT 577



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 46/188 (24%), Positives = 70/188 (37%), Gaps = 29/188 (15%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            +V + ++    L C  +G   P V W+ D             + A    ++      +  
Sbjct: 1076 QVSVVQDGVATLECNATGKPPPTVTWERD----------GQPVGAELGLQLQNQGQSLHV 1125

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-----KPTVNIPSSATIGNRAVL 151
            +      TG Y+C+     G +  E K +L VLVPP       P  NI  +A + +   L
Sbjct: 1126 ERAQAAHTGRYSCVAENLAGRA--ERKFELSVLVPPELIGDLDPLTNI--TAALHSPLTL 1181

Query: 152  TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
             C E  G PP    WF+     P +P          ++L  T  +         D+G YS
Sbjct: 1182 LC-EAMGIPPPAIRWFRG--EEPVSPGEDTYLLAGGWMLKMTQTQ-------EQDSGLYS 1231

Query: 212  CEARNGYG 219
            C A N  G
Sbjct: 1232 CLASNEAG 1239



 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 49/200 (24%), Positives = 82/200 (41%), Gaps = 31/200 (15%)

Query: 37  EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
           EV + E++ V+L C   G  +P + W F  G    L+  + K+  +   R       +  
Sbjct: 320 EVAVMEDHLVQLLCEARGVPTPNITW-FKDG---ALLPTSTKVVYTRGGR------QLQL 369

Query: 97  KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS------KPTVNIPSSATIGNRAV 150
                 D G YTC  S   G +  E   +L V VPP+      +P V     A  G    
Sbjct: 370 GRAQSSDAGVYTCKASNAVGAA--EKATRLDVYVPPTIEGAGGRPYV---VKAVAGRPVA 424

Query: 151 LTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEY 210
           L C  + G P    +W  +G+ +  + +S R  ++ S +   + GE        + +G Y
Sbjct: 425 LECVAR-GHPSPTLSWHHEGLPVAESNES-RLETDGSVLRLESPGE--------ASSGLY 474

Query: 211 SCEARNGYGTPMTSNAVRME 230
           SC A +  G  +   +V ++
Sbjct: 475 SCVASSPAGEAVLQYSVEVQ 494



 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 49/199 (24%), Positives = 73/199 (36%), Gaps = 35/199 (17%)

Query: 30   TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVT- 88
            T+   + +  +    PV L+C  +G  +P V W              +K  A    R + 
Sbjct: 2667 TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW--------------SKAGAQLGARGSG 2712

Query: 89   --FLPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVN-IPSSA- 143
                P+G +          G YTC      G ++     K + L   + P V  +PS   
Sbjct: 2713 YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-----KHVFLTVQASPVVKPLPSVVR 2767

Query: 144  TIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLS 203
             +    VL   E  G P    TW K+G+ + T          S+ VL    G+L     S
Sbjct: 2768 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGV--------STQVL--PGGQLRIAHAS 2817

Query: 204  ASDTGEYSCEARNGYGTPM 222
              D G Y C A+N  G+ M
Sbjct: 2818 PEDAGNYLCIAKNSAGSAM 2836



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 14/122 (11%)

Query: 50  CAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTC 109
           C   G   P+V W+  +G ++  + +     A  E+   FL       SV+  D+G Y C
Sbjct: 24  CGTHGTPKPQVTWR--KGPSSEPL-HGQPGVAVLEEGSLFLA------SVSPADSGDYEC 74

Query: 110 MVSEEGGNSYGEVKVKLIVLVPPS--KPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWF 167
             + E G++    + KL+V VPPS  +       S   G    L C + +G P  E  W 
Sbjct: 75  QATNEVGST--SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLEC-DANGFPVPEIVWL 131

Query: 168 KD 169
           KD
Sbjct: 132 KD 133



 Score = 35.4 bits (80), Expect = 0.061
 Identities = 37/197 (18%), Positives = 68/197 (34%), Gaps = 27/197 (13%)

Query: 28   SVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRV 87
            S+     E  +++ +     L C  +G   P++ W  D     R             D  
Sbjct: 1254 SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR------------GDAH 1301

Query: 88   TFLPTGITFK--SVTREDTGTYTCMVSEEGGNSYGEVKVKLIV---LVPPSKPTVNIPSS 142
               P G+  +         G Y+C+ +   G      ++ +++   ++  ++ + +   +
Sbjct: 1302 HISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVT 1361

Query: 143  ATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPL 202
             T+ N   L C E    P    TW KDG             ++ +  L P T  L     
Sbjct: 1362 VTVNNPISLIC-EALAFPSPNITWMKDGAPFE---------ASRNIQLLPGTHGLQILNA 1411

Query: 203  SASDTGEYSCEARNGYG 219
               D G+Y+C   N  G
Sbjct: 1412 QKEDAGQYTCVVTNELG 1428



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 25/89 (28%), Positives = 37/89 (41%), Gaps = 14/89 (15%)

Query: 24   LALGSVTVHSSEPE-VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITAS 82
            L L S  V   EP+ + +   + V L C  +G  +P +EW    G   R           
Sbjct: 3112 LVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRA---------- 3160

Query: 83   YEDRVTFLPTG-ITFKSVTREDTGTYTCM 110
               R+  LP G +  ++V   D GTY C+
Sbjct: 3161 -SRRLRTLPDGSLWLENVETGDAGTYDCV 3188



 Score = 28.1 bits (61), Expect = 9.8
 Identities = 17/63 (26%), Positives = 27/63 (42%), Gaps = 8/63 (12%)

Query: 158 GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
           G+P  + TW K     P + +   A            G L    +S +D+G+Y C+A N 
Sbjct: 28  GTPKPQVTWRKGPSSEPLHGQPGVAVLEE--------GSLFLASVSPADSGDYECQATNE 79

Query: 218 YGT 220
            G+
Sbjct: 80  VGS 82


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 60/211 (28%), Positives = 82/211 (38%), Gaps = 28/211 (13%)

Query: 15   FILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVC 74
            F L++LL    LG     S++ EV +  NNP+ L C    F SP + W  D         
Sbjct: 2529 FQLSVLLAPTILGGAE-DSADEEVTVTVNNPISLICEALAFPSPNITWMKD--------- 2578

Query: 75   YNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS- 133
                  AS   ++     G+   +  +ED G YTC+V+ E G +     V+  VL+PPS 
Sbjct: 2579 -GAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVE--VLIPPSI 2635

Query: 134  -----KPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSY 188
                    V +    T  N  +    E    PP    W+KDG   P  P S         
Sbjct: 2636 SKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDG--QPVTPSSRLQVLGEGR 2693

Query: 189  VLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            +L          P   SD+G Y C A N  G
Sbjct: 2694 LLQ-------IQPTQVSDSGRYLCVATNVAG 2717



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 53/193 (27%), Positives = 80/193 (41%), Gaps = 32/193 (16%)

Query: 29  VTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYED-RV 87
           V++H+S       +   VK+SC+ SG+ +P + W             + +  A  ED R+
Sbjct: 610 VSIHTSSQH--FSQGVEVKVSCSASGYPTPHISW-------------SRESQALQEDSRI 654

Query: 88  TFLPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIG 146
                G +  + V  ED G Y+C  + E G    +  V L    PPS   VN      +G
Sbjct: 655 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD--QETVTLYYTDPPSVSAVNAVVLVAVG 712

Query: 147 NRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASD 206
             AVL C E  G PP    W++ G+ M   P+ +            ++G+L        D
Sbjct: 713 EEAVLVC-EASGVPPPRVIWYRGGLEMILAPEGS------------SSGKLRIPAAQERD 759

Query: 207 TGEYSCEARNGYG 219
            G Y+C A N  G
Sbjct: 760 AGTYTCRAVNELG 772



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 54/183 (29%), Positives = 74/183 (40%), Gaps = 25/183 (13%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITF 96
            VR      V L C  SG   P + W+ +             +      +V  LP G +  
Sbjct: 3957 VRAVAEEEVLLPCEASGIPRPTITWQKE----------GLNVATGVSTQV--LPGGQLRI 4004

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQ 156
               + ED G Y C+     G++ G  K +L+V VPP         S T G+ A L C  +
Sbjct: 4005 AHASPEDAGNYLCIAKNSAGSAMG--KTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR 4062

Query: 157  DGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
             GSP    TW KDG      P S    +   + + P+ GEL+   L   D G Y+C A N
Sbjct: 4063 -GSPEPNITWDKDG-----QPVSG---AEGKFTIQPS-GELLVKNLEGQDAGTYTCTAEN 4112

Query: 217  GYG 219
              G
Sbjct: 4113 AVG 4115



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 57/203 (28%), Positives = 83/203 (40%), Gaps = 38/203 (18%)

Query: 33   SSEP-EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLP 91
            S +P E+ +    P++L C   G   P + W  D    TRL    N   A+   RV    
Sbjct: 3499 SGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRL---ENNSRATRVLRV---- 3551

Query: 92   TGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIV---LVPPSKPTVNIPSSATIGNR 148
                       D G YTC+     G      +V++     +V P  P   +  +     +
Sbjct: 3552 ----------RDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP---GQ 3598

Query: 149  AVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGE-LVFDPLSASDT 207
             VL CS +   P  + TW +DGIV+             ++   P  G  L    LS +D+
Sbjct: 3599 LVLECSVE-AEPAPKITWHRDGIVL----------QEDAHTQFPERGRFLQLQALSTADS 3647

Query: 208  GEYSCEARNGYGTPMTSNAVRME 230
            G+YSC ARN  G+  TS A R+E
Sbjct: 3648 GDYSCTARNAAGS--TSVAFRVE 3668



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 73/297 (24%), Positives = 115/297 (38%), Gaps = 51/297 (17%)

Query: 24   LALGSVTVHSSEP-EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITAS 82
            LA+G     +  P +V +       L+C  +G   P V W+   G    L     ++ A 
Sbjct: 780  LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-----RLGAG 834

Query: 83   YEDRVTFLPTGITF-KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPS 141
               R     +G+ F +SV  ED   Y C    E  N +G+V+ +  ++V    P     S
Sbjct: 835  RGSRSRQPDSGVLFFESVAPEDQAPYVC----EARNVFGKVQAEARLIVTGHAPPQIASS 890

Query: 142  SATI----GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPK-STRAFSNSSYVLNPTTGE 196
            + T+    G    L C    G P  E  W KDG  +P   + S RA            G 
Sbjct: 891  APTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA-----------DGS 939

Query: 197  LVFDPLSASDTGEYSCEARNGYGT----------------PMTSNAVRMEAVERNVGVIV 240
            L  D       G YSC A N  G+                P  ++ +  E V  ++  + 
Sbjct: 940  LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVA 999

Query: 241  AAVLVTLILLGILVFGIWFAYSRG-HFDRTKKGTSSKKVIYSQPSARSEGEFKQTSS 296
            + V    I        +    SRG H++ +K+GT    ++ +QPSA+  G +  T++
Sbjct: 1000 SGVPAPTITWTKETNAL---TSRGPHYNVSKEGT----LLIAQPSAQDAGAYVCTAT 1049



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 47/179 (26%), Positives = 70/179 (39%), Gaps = 24/179 (13%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--ITFKSVT 100
            N PV+L+C  +G  SP + W  D           N ++ +    +   P G  +T  S  
Sbjct: 1992 NTPVRLTCNATGAPSPTLMWLKD----------GNPVSPAGTPGLQVFPGGRVLTLASAR 2041

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSP 160
              D+G Y+C+     G    +V ++  V +PPS     +  S        L C +    P
Sbjct: 2042 ASDSGRYSCVAVSAVGEDRQDVVLQ--VHMPPSILGEELNVSVVANESVALEC-QSHAMP 2098

Query: 161  PSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            P   +W+KDG   P  P+     S    +L         D     D G Y+CEA N  G
Sbjct: 2099 PPVLSWWKDG--RPLEPRPGVHLSADKALLQ-------VDRADVWDAGHYTCEALNQAG 2148



 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 52/185 (28%), Positives = 72/185 (38%), Gaps = 34/185 (18%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK--SVT 100
            N+ V L C      +P V W            Y +    S  + V  LP   T +     
Sbjct: 2952 NSSVSLPCDVHAHPNPEVTW------------YKDSQALSLGEEVFLLPGTHTLQLGRAR 2999

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-KPTVNIPSSAT---IGNRAVLTCSEQ 156
              D+G YTC      G    +  V+L VLVPP+ +     P  A    +G++AVL+C E 
Sbjct: 3000 LSDSGMYTCEALNAAGRD--QKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSC-ET 3056

Query: 157  DGSPPSEYTWFKDG--IVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
            D  P    TW+KDG  +V+    ++ R               L       SD G YSC+ 
Sbjct: 3057 DALPEPTVTWYKDGQPLVLAQRTQALRGGQ-----------RLEIQEAQVSDKGLYSCKV 3105

Query: 215  RNGYG 219
             N  G
Sbjct: 3106 SNVAG 3110



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 52/180 (28%), Positives = 74/180 (41%), Gaps = 23/180 (12%)

Query: 42   ENNPVKLSCAYSGFSSPRVEW-KFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVT 100
            EN  V L C  SG   P V W K  Q  ++ +      +T S + RV      +  +   
Sbjct: 1899 ENASVTLECLASGVPPPDVSWFKGHQPVSSWM-----GVTVSVDGRV------LRIEQAQ 1947

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-KPTVNIPSSATIGNRAVLTCSEQDGS 159
              D G+Y C+ S   G++  E++  L V VPP      ++P    +     LTC+   G+
Sbjct: 1948 LSDAGSYRCVASNVAGST--ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCN-ATGA 2004

Query: 160  PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            P     W KDG   P +P  T         + P    L      ASD+G YSC A +  G
Sbjct: 2005 PSPTLMWLKDG--NPVSPAGTPGLQ-----VFPGGRVLTLASARASDSGRYSCVAVSAVG 2057



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 50/191 (26%), Positives = 70/191 (36%), Gaps = 22/191 (11%)

Query: 30   TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTF 89
            T+ S  P V +  N    L C   G  +P V W+ D+                   R   
Sbjct: 3674 TIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD-----------PRSPRFEI 3722

Query: 90   LPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNR 148
            LP G +  + V  +D G Y C+ S   G+        L VL PP+        + T    
Sbjct: 3723 LPEGSLRIQPVLAQDAGHYLCLASNSAGSD--RQGRDLRVLEPPAIAPSPSNLTLTAHTP 3780

Query: 149  AVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTG 208
            A+L C E  GSP     W+KDG       K        +Y L P+   L+  P    D+ 
Sbjct: 3781 ALLPC-EASGSPKPLVVWWKDG------QKLDFRLQQGAYRLLPSNALLLTAP-GPQDSA 3832

Query: 209  EYSCEARNGYG 219
            ++ C   N  G
Sbjct: 3833 QFECVVSNEVG 3843



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 54/220 (24%), Positives = 84/220 (38%), Gaps = 42/220 (19%)

Query: 40   IPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--ITFK 97
            I ENNP  L C  +    P + W            Y      S  D V+ L  G  +   
Sbjct: 2762 IVENNPAYLYCDTNAIPPPDLTW------------YREDQPLSAGDEVSVLQGGRVLQIP 2809

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP----------SKPTVNIPSSATIGN 147
             V  E+ G Y+C  S E G  +  +  +L+VL PP           + TVN  S+ ++  
Sbjct: 2810 LVRAENAGRYSCKASNEVGEDW--LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC 2867

Query: 148  RAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDT 207
             A+       G+P    +W ++G  +P +P           VL  +T E+       +D 
Sbjct: 2868 PAL-------GNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEV-------ADA 2911

Query: 208  GEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTL 247
              Y C A N  G+      +R++   R  G+ +  V   L
Sbjct: 2912 ASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAIL 2951



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 46/176 (26%), Positives = 66/176 (37%), Gaps = 18/176 (10%)

Query: 44   NPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRED 103
            +P+ L+C  SG  +P V W  D+            + +S    V      +    +    
Sbjct: 3140 SPLVLTCDVSGVPAPTVTWLKDR----------MPVESSAVHGVVSRGGRLQLSRLQPAQ 3189

Query: 104  TGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
             GTYTC+       +  +  V ++V        V        G    L C E DG PP +
Sbjct: 3190 AGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC-EADGQPPPD 3248

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              W KDG     +P       +  + L+   G LV   L ASD G Y+C A N  G
Sbjct: 3249 VAWLKDG-----SPLGQDMGPHLRFYLD--GGSLVLKGLRASDAGAYTCVAHNPAG 3297



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 43/184 (23%), Positives = 78/184 (42%), Gaps = 26/184 (14%)

Query: 48   LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
            L C+     +P++ W  D       +         + +R  FL      ++++  D+G Y
Sbjct: 3601 LECSVEAEPAPKITWHRDG------IVLQEDAHTQFPERGRFLQ----LQALSTADSGDY 3650

Query: 108  TCMVSEEGGNSYGEVKVKL--IVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYT 165
            +C      G++    +V++  +  +    P VN+    ++   A+L C + DG P    +
Sbjct: 3651 SCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNV----SVNQTALLPC-QADGVPAPLVS 3705

Query: 166  WFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSN 225
            W KD +  P +P+S R      + + P  G L   P+ A D G Y C A N  G+     
Sbjct: 3706 WRKDRV--PLDPRSPR------FEILPE-GSLRIQPVLAQDAGHYLCLASNSAGSDRQGR 3756

Query: 226  AVRM 229
             +R+
Sbjct: 3757 DLRV 3760



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 47/176 (26%), Positives = 68/176 (38%), Gaps = 27/176 (15%)

Query: 48  LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
           L C  SG   PRV W   +G    ++      +             +   +    D GTY
Sbjct: 717 LVCEASGVPPPRVIWY--RGGLEMILAPEGSSSGK-----------LRIPAAQERDAGTY 763

Query: 108 TCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI--GNRAVLTCSEQDGSPPSEYT 165
           TC    E G++  E+++     V  +     +P   T+  G  A+L C    G PP   T
Sbjct: 764 TCRAVNELGDASAEIQLA----VGHAPQLTELPRDVTVELGRSALLAC-RATGRPPPTVT 818

Query: 166 WFK-DGIVMPTNPKSTR-AFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           W + DG      P   R      S    P +G L F+ ++  D   Y CEARN +G
Sbjct: 819 WRRGDG-----QPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFG 869



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 50/186 (26%), Positives = 72/186 (38%), Gaps = 27/186 (14%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            EV +  ++ V L C   G   P + W              N +  S   R+  L  G   
Sbjct: 2854 EVTVNASSTVSLQCPALGNPVPTISW------------LQNGLPFSPSPRLQVLEDGQVL 2901

Query: 97   KSVTRE--DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCS 154
            +  T E  D  +Y C+   + G++  E    L V VPP    +++     I N +V    
Sbjct: 2902 QVSTAEVADAASYMCVAENQAGSA--EKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPC 2959

Query: 155  EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYV-LNPTTGELVFDPLSASDTGEYSCE 213
            +    P  E TW+KD          ++A S    V L P T  L       SD+G Y+CE
Sbjct: 2960 DVHAHPNPEVTWYKD----------SQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 3009

Query: 214  ARNGYG 219
            A N  G
Sbjct: 3010 ALNAAG 3015



 Score = 51.6 bits (122), Expect = 8e-07
 Identities = 48/181 (26%), Positives = 67/181 (37%), Gaps = 28/181 (15%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK--SVT 100
            ++P+ L C   G   P + W            +  +   S  +    L  G   K     
Sbjct: 2367 HSPLTLLCEAMGIPPPAIRW------------FRGEEPVSPGEDTYLLAGGWMLKMTQTQ 2414

Query: 101  REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI--GNRAVLTCSEQDG 158
             +D+G Y+C+ S E G +     V+  VLVPPS    ++     +  G  A L C+   G
Sbjct: 2415 EQDSGLYSCLASNEAGEARRNFSVE--VLVPPSIENEDLEEVIKVLDGQTAHLMCN-VTG 2471

Query: 159  SPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGY 218
             P  + TWFKDG   P         S    +L      L       S  G YSC A N  
Sbjct: 2472 HPQPKLTWFKDG--RPLARGDAHHISPDGVLLQVLQANL-------SSAGHYSCIAANAV 2522

Query: 219  G 219
            G
Sbjct: 2523 G 2523



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 48/175 (27%), Positives = 68/175 (38%), Gaps = 21/175 (12%)

Query: 46   VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
            V+L C  SG  +P+VEW  D+    + V          ED      TG         D G
Sbjct: 1426 VELQCWTSGVPTPQVEWTKDR----QPVLPGGPHLQVQEDGQVLRITGSHVG-----DEG 1476

Query: 106  TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS-ATIGNRAVLTCSEQDGSPPSEY 164
             Y C+     G    + +++  V  PP+    N     A + +  V    E  G P    
Sbjct: 1477 RYQCVAFSPAGQQARDFQLR--VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 1534

Query: 165  TWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            TWFKDG ++PT+ K          V      +L      +SD G Y+C+A N  G
Sbjct: 1535 TWFKDGALLPTSTK---------VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 1580



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 46/184 (25%), Positives = 70/184 (38%), Gaps = 31/184 (16%)

Query: 40   IPENNPVKLSCAYSGFSSPRVEWKFD----QGDTTRLVCYNNKITASYEDRVTFLPTGIT 95
            + E +P  LSC   G   P++ W+ D     G+   L              V+ +   + 
Sbjct: 2174 VREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGL------------QHVSAVGRLLY 2221

Query: 96   FKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIV---LVPPSKPTVNIPSSATIGNRAVLT 152
                     GTYTC  S   GNS  ++++++ V   +  P +P   +  S      A L 
Sbjct: 2222 LGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV--SVVQDGVATLE 2279

Query: 153  CSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSC 212
            C+   G PP   TW +DG   P   +      N    L+        +   A+ TG YSC
Sbjct: 2280 CN-ATGKPPPTVTWERDG--QPVGAELGLQLQNQGQSLH-------VERAQAAHTGRYSC 2329

Query: 213  EARN 216
             A N
Sbjct: 2330 VAEN 2333



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 42/145 (28%), Positives = 58/145 (40%), Gaps = 12/145 (8%)

Query: 90   LPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRA 149
            LP  +  + V   D G YTC  +   G S  EV +K  VLVPP+     + + A + N +
Sbjct: 1846 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK--VLVPPNIEPGPV-NKAVLENAS 1902

Query: 150  VLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGE 209
            V       G PP + +WFK     P +       S    VL     +L       SD G 
Sbjct: 1903 VTLECLASGVPPPDVSWFKGH--QPVSSWMGVTVSVDGRVLRIEQAQL-------SDAGS 1953

Query: 210  YSCEARNGYGTPMTSNAVRMEAVER 234
            Y C A N  G+      +R+    R
Sbjct: 1954 YRCVASNVAGSTELRYGLRVNVPPR 1978



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 38/245 (15%)

Query: 15   FILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVC 74
            F++A+L+      S        E  + E   V+L C   G   P V W  D         
Sbjct: 3208 FVVAVLVAPRIRSSGVAR----EHHVLEGQEVRLDCEADGQPPPDVAWLKD--------- 3254

Query: 75   YNNKITASYEDRVTFLPTG--ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP 132
              + +       + F   G  +  K +   D G YTC+     G       V   VLVPP
Sbjct: 3255 -GSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVN--VLVPP 3311

Query: 133  SKPTVNIPSSATI---GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYV 189
            +       S   +   G    + C  + GSPP   +W KDG+ +P + ++         +
Sbjct: 3312 TIKQGADGSGTLVSRPGELVTMVCPVR-GSPPIHVSWLKDGLPLPLSQRT---------L 3361

Query: 190  LNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVR------MEAVE-RNVGVIVAA 242
            L+ +   L    +  +D G ++C A +  G    +  ++      +E VE +N  V+V  
Sbjct: 3362 LHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRG 3421

Query: 243  VLVTL 247
             LV L
Sbjct: 3422 SLVEL 3426



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 47/201 (23%), Positives = 77/201 (38%), Gaps = 26/201 (12%)

Query: 31   VHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFL 90
            + +  P++   E +   L C   G   P + W  D            +  +  E + T  
Sbjct: 4040 IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKD-----------GQPVSGAEGKFTIQ 4088

Query: 91   PTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRA 149
            P+G +  K++  +D GTYTC      G +    +V L +LV P   T+    S  +G+R 
Sbjct: 4089 PSGELLVKNLEGQDAGTYTCTAENAVGRA--RRRVHLTILVLPVFTTLPGDRSLRLGDRL 4146

Query: 150  VLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGE 209
             L C+ + GSP     W  +    P     +     S+         L    +S  D+G 
Sbjct: 4147 WLRCAAR-GSPTPRIGWTVND--RPVTEGVSEQDGGST---------LQRAAVSREDSGT 4194

Query: 210  YSCEARNGYGTPMTSNAVRME 230
            Y C A N  G     + V ++
Sbjct: 4195 YVCWAENRVGRTQAVSFVHVK 4215



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 53/203 (26%), Positives = 79/203 (38%), Gaps = 35/203 (17%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            +V +   + V+L C   G   P V W  D G+          ++ S E   +     +  
Sbjct: 3415 DVVVVRGSLVELPCEARGVPLPLVSWMKD-GEPL--------LSQSLEQGPS-----LQL 3460

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPS--SATIGNRAVLTCS 154
            ++V   D+GTY+C+   E G +      +L V+ PP       P+  S T G    L C 
Sbjct: 3461 EAVGAGDSGTYSCVAVSEAGEA--RRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD 3518

Query: 155  EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
             Q G+P    TW KDG  +     ++RA                   L   D G Y+C A
Sbjct: 3519 AQ-GTPQPNITWHKDGQALTRLENNSRATR----------------VLRVRDAGLYTCLA 3561

Query: 215  RNGYGTPMTSNAVRMEAVERNVG 237
             +  G    S  VR++A    VG
Sbjct: 3562 ESPAGAIEKSFRVRVQAPPNIVG 3584



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 49/182 (26%), Positives = 73/182 (40%), Gaps = 22/182 (12%)

Query: 48   LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
            L C   G   P+V W+  +G ++  + +     A  E+   FL       SV+  D+G Y
Sbjct: 1226 LPCPARGTPKPQVTWR--KGPSSEPL-HGQPGVAVLEEGSLFLA------SVSPADSGDY 1276

Query: 108  TCMVSEEGGNSYGEVKVKLIVLVPPS--KPTVNIPSSATIGNRAVLTCSEQDGSPPSEYT 165
             C  + E G++    + KL+V VPPS  +       S   G    L C + +G P  E  
Sbjct: 1277 ECQATNEVGST--SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLEC-DANGFPVPEIV 1333

Query: 166  WFKDGIVMPTNPKSTRAFS-------NSSYVLNPTTGELVFDPLSASDTGEYSCEARNGY 218
            W KD  ++   P     +           + L      L F  +   D+G YSC A N  
Sbjct: 1334 WLKDAQLVGV-PLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQA 1392

Query: 219  GT 220
            GT
Sbjct: 1393 GT 1394



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 35/127 (27%), Positives = 51/127 (40%), Gaps = 16/127 (12%)

Query: 100 TREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSK--PTVNIPSSATIGNRAVLTCSEQD 157
           ++ + GTY C      G   G  K +++V  PP +  P  N+  S   G  AVL+C    
Sbjct: 487 SKAEEGTYECTAVSRAGT--GRAKAQIVVTDPPPQLVPAPNVTVSP--GETAVLSCRVL- 541

Query: 158 GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
           G  P   TW +D  V+P +       ++ S         L    +  +D G Y C A N 
Sbjct: 542 GEAPYNLTWVRDWRVLPASTGRVAQLADLS---------LEISGIIPTDGGRYQCVASNA 592

Query: 218 YGTPMTS 224
            G    S
Sbjct: 593 NGVTRAS 599



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 50/190 (26%), Positives = 72/190 (37%), Gaps = 24/190 (12%)

Query: 31   VHSSEPEVRIPENNPVKLSC-AYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTF 89
            + SS P VR+ E  PV L C   +G   P   W  D         ++ +   S       
Sbjct: 887  IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS------- 939

Query: 90   LPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRA 149
                +      +E  G Y+C+ +   G+ + +V+  L+V VPP             G  A
Sbjct: 940  ----LHLDRALQEHAGRYSCVATNTAGSQHRDVE--LVVQVPPRIHPTATHHITNEGVPA 993

Query: 150  VLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGE 209
             L C    G P    TW K+     TN  ++R      Y ++     L+  P SA D G 
Sbjct: 994  SLPCVAS-GVPAPTITWTKE-----TNALTSRG---PHYNVSKEGTLLIAQP-SAQDAGA 1043

Query: 210  YSCEARNGYG 219
            Y C A N  G
Sbjct: 1044 YVCTATNTVG 1053



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 36/131 (27%), Positives = 51/131 (38%), Gaps = 19/131 (14%)

Query: 90   LPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNR 148
            LP+G +    V   D+G Y C  S   G++    +  L V VPP            +G  
Sbjct: 1079 LPSGSLRLAQVQVGDSGHYECTASNPAGSA--SHRYVLGVQVPPQVQPGPRVLKVLVGEA 1136

Query: 149  AVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTG 208
              L C  + G+P  + +W KDG+V+                     G + F  +  SD G
Sbjct: 1137 LDLNCVAE-GNPEPQLSWSKDGVVLQGRGPQ---------------GSVHFAAIRTSDAG 1180

Query: 209  EYSCEARNGYG 219
             Y CEA N  G
Sbjct: 1181 RYRCEASNSAG 1191



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 44/187 (23%), Positives = 66/187 (35%), Gaps = 38/187 (20%)

Query: 41   PENNPVKLSCAYSGFSSPRVEWKFD----QGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            P    ++L C   G   P + W  D    +G   R    N  +T    +R          
Sbjct: 4231 PVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTER---------- 4280

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNI-PSSATI--GNRAVLTC 153
                 +D G Y C+   E G     V  K+++LV  S P   + P   T+  G+   L C
Sbjct: 4281 -----DDAGRYQCLAENEMG-----VAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRC 4330

Query: 154  SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCE 213
             +  G P     W + G  +  + +       S ++ N  TG          D G Y C 
Sbjct: 4331 -QATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG----------DAGTYDCV 4379

Query: 214  ARNGYGT 220
            A N  G+
Sbjct: 4380 AHNLLGS 4386



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 35/118 (29%), Positives = 48/118 (40%), Gaps = 19/118 (16%)

Query: 103  DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI----GNRAVLTCSEQDG 158
            D G Y+C VS   G +     V+   L     PT   P + T+    G+  VLTC +  G
Sbjct: 3097 DKGLYSCKVSNVAGEA-----VRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTC-DVSG 3150

Query: 159  SPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
             P    TW KD   MP         S++ + +    G L    L  +  G Y+C A N
Sbjct: 3151 VPAPTVTWLKDR--MPVE-------SSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 3199



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 34/129 (26%), Positives = 51/129 (39%), Gaps = 13/129 (10%)

Query: 94   ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPS--SATIGNRAVL 151
            + F ++   D G Y C  S   G    EV+++  VL PP               G  A L
Sbjct: 1169 VHFAAIRTSDAGRYRCEASNSAGVDAWEVELR--VLEPPHWGADETSGLLERVAGENASL 1226

Query: 152  TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
             C  + G+P  + TW K     P + +   A            G L    +S +D+G+Y 
Sbjct: 1227 PCPAR-GTPKPQVTWRKGPSSEPLHGQPGVAVLEE--------GSLFLASVSPADSGDYE 1277

Query: 212  CEARNGYGT 220
            C+A N  G+
Sbjct: 1278 CQATNEVGS 1286



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 42/185 (22%), Positives = 67/185 (36%), Gaps = 24/185 (12%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
            V+     PV L C   G  SP + W  +             +  S E R+    + +  +
Sbjct: 1606 VKAVAGRPVALECVARGHPSPTLSWHHE----------GLPVAESNESRLETDGSVLRLE 1655

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSAT--IGNRAVLTCSE 155
            S     +G Y+C+ S   G +  +  V+  V VPP           T  +G    L C +
Sbjct: 1656 SPGEASSGLYSCVASSPAGEAVLQYSVE--VQVPPQLLVAEGLGQVTTIVGQPLELPC-Q 1712

Query: 156  QDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
              GSP     W ++G       +     +        TT  L  D +    +G ++C+A 
Sbjct: 1713 ASGSPVPTIQWLQNG-------RPAEELAGVQVASQGTT--LHIDHVELDHSGLFACQAT 1763

Query: 216  NGYGT 220
            N  GT
Sbjct: 1764 NEAGT 1768



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 46/188 (24%), Positives = 70/188 (37%), Gaps = 29/188 (15%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            +V + ++    L C  +G   P V W+ D             + A    ++      +  
Sbjct: 2267 QVSVVQDGVATLECNATGKPPPTVTWERD----------GQPVGAELGLQLQNQGQSLHV 2316

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-----KPTVNIPSSATIGNRAVL 151
            +      TG Y+C+     G +  E K +L VLVPP       P  NI  +A + +   L
Sbjct: 2317 ERAQAAHTGRYSCVAENLAGRA--ERKFELSVLVPPELIGDLDPLTNI--TAALHSPLTL 2372

Query: 152  TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
             C E  G PP    WF+     P +P          ++L  T  +         D+G YS
Sbjct: 2373 LC-EAMGIPPPAIRWFRG--EEPVSPGEDTYLLAGGWMLKMTQTQ-------EQDSGLYS 2422

Query: 212  CEARNGYG 219
            C A N  G
Sbjct: 2423 CLASNEAG 2430



 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 49/200 (24%), Positives = 82/200 (41%), Gaps = 31/200 (15%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            EV + E++ V+L C   G  +P + W F  G    L+  + K+  +   R       +  
Sbjct: 1511 EVAVMEDHLVQLLCEARGVPTPNITW-FKDG---ALLPTSTKVVYTRGGR------QLQL 1560

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS------KPTVNIPSSATIGNRAV 150
                  D G YTC  S   G +  E   +L V VPP+      +P V     A  G    
Sbjct: 1561 GRAQSSDAGVYTCKASNAVGAA--EKATRLDVYVPPTIEGAGGRPYV---VKAVAGRPVA 1615

Query: 151  LTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEY 210
            L C  + G P    +W  +G+ +  + +S R  ++ S +   + GE        + +G Y
Sbjct: 1616 LECVAR-GHPSPTLSWHHEGLPVAESNES-RLETDGSVLRLESPGE--------ASSGLY 1665

Query: 211  SCEARNGYGTPMTSNAVRME 230
            SC A +  G  +   +V ++
Sbjct: 1666 SCVASSPAGEAVLQYSVEVQ 1685



 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 49/199 (24%), Positives = 73/199 (36%), Gaps = 35/199 (17%)

Query: 30   TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVT- 88
            T+   + +  +    PV L+C  +G  +P V W              +K  A    R + 
Sbjct: 3858 TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW--------------SKAGAQLGARGSG 3903

Query: 89   --FLPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVN-IPSSA- 143
                P+G +          G YTC      G ++     K + L   + P V  +PS   
Sbjct: 3904 YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-----KHVFLTVQASPVVKPLPSVVR 3958

Query: 144  TIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLS 203
             +    VL   E  G P    TW K+G+ + T          S+ VL    G+L     S
Sbjct: 3959 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGV--------STQVL--PGGQLRIAHAS 4008

Query: 204  ASDTGEYSCEARNGYGTPM 222
              D G Y C A+N  G+ M
Sbjct: 4009 PEDAGNYLCIAKNSAGSAM 4027



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 43/189 (22%), Positives = 74/189 (39%), Gaps = 31/189 (16%)

Query: 36  PEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPT-GI 94
           P V +       LSC   G +   + W  D            ++  +   RV  L    +
Sbjct: 524 PNVTVSPGETAVLSCRVLGEAPYNLTWVRDW-----------RVLPASTGRVAQLADLSL 572

Query: 95  TFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAV---L 151
               +   D G Y C+ S    N+ G  +  + +LV  + P V+I +S+   ++ V   +
Sbjct: 573 EISGIIPTDGGRYQCVAS----NANGVTRASVWLLVREA-PQVSIHTSSQHFSQGVEVKV 627

Query: 152 TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
           +CS   G P    +W ++          ++A    S +     G L+   ++  D G YS
Sbjct: 628 SCSAS-GYPTPHISWSRE----------SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 676

Query: 212 CEARNGYGT 220
           C+A N  GT
Sbjct: 677 CQATNEVGT 685



 Score = 35.4 bits (80), Expect = 0.061
 Identities = 37/197 (18%), Positives = 68/197 (34%), Gaps = 27/197 (13%)

Query: 28   SVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRV 87
            S+     E  +++ +     L C  +G   P++ W  D     R             D  
Sbjct: 2445 SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR------------GDAH 2492

Query: 88   TFLPTGITFK--SVTREDTGTYTCMVSEEGGNSYGEVKVKLIV---LVPPSKPTVNIPSS 142
               P G+  +         G Y+C+ +   G      ++ +++   ++  ++ + +   +
Sbjct: 2493 HISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVT 2552

Query: 143  ATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPL 202
             T+ N   L C E    P    TW KDG             ++ +  L P T  L     
Sbjct: 2553 VTVNNPISLIC-EALAFPSPNITWMKDGAPFE---------ASRNIQLLPGTHGLQILNA 2602

Query: 203  SASDTGEYSCEARNGYG 219
               D G+Y+C   N  G
Sbjct: 2603 QKEDAGQYTCVVTNELG 2619



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 25/89 (28%), Positives = 37/89 (41%), Gaps = 14/89 (15%)

Query: 24   LALGSVTVHSSEPE-VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITAS 82
            L L S  V   EP+ + +   + V L C  +G  +P +EW    G   R           
Sbjct: 4303 LVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRA---------- 4351

Query: 83   YEDRVTFLPTG-ITFKSVTREDTGTYTCM 110
               R+  LP G +  ++V   D GTY C+
Sbjct: 4352 -SRRLRTLPDGSLWLENVETGDAGTYDCV 4379



 Score = 29.6 bits (65), Expect = 3.4
 Identities = 45/192 (23%), Positives = 62/192 (32%), Gaps = 20/192 (10%)

Query: 48   LSCAYSGFSSPRVEWKFDQ---GDTTRLVCYNNKITASYEDRVTFLPTG--ITFKSVTRE 102
            L C  +GF  P + W  D    G       Y   +          L  G  + F  +   
Sbjct: 1320 LECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEG 1379

Query: 103  DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS--ATIGNRAVLTCSEQDGSP 160
            D+G Y+C    + G +  +    L+VL PPS              G    L C    G P
Sbjct: 1380 DSGLYSCRAENQAGTAQRD--FHLLVLTPPSVLGAGAAQEVLGLAGADVELQC-WTSGVP 1436

Query: 161  PSEYTWFKD-GIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              +  W KD   V+P  P           VL  T   +        D G Y C A +  G
Sbjct: 1437 TPQVEWTKDRQPVLPGGPH--LQVQEDGQVLRITGSHV-------GDEGRYQCVAFSPAG 1487

Query: 220  TPMTSNAVRMEA 231
                   +R+ A
Sbjct: 1488 QQARDFQLRVHA 1499


>gi|4503173 coxsackie virus and adenovirus receptor precursor [Homo
           sapiens]
          Length = 365

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 70/273 (25%), Positives = 117/273 (42%), Gaps = 44/273 (16%)

Query: 12  LCLFILAILLCSLA--LGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPR------VEWK 63
           + L +  +LLC +     S+++ + E  +   +     L C ++   SP       +EW 
Sbjct: 1   MALLLCFVLLCGVVDFARSLSITTPEEMIEKAKGETAYLPCKFT--LSPEDQGPLDIEWL 58

Query: 64  FDQGDTTR----LVCYN-NKITASY----EDRVTF----LPTGITFKSVTR---EDTGTY 107
               D  +    ++ Y+ +KI   Y    + RV F    L +G    +VT     D GTY
Sbjct: 59  ISPADNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDLKSGDASINVTNLQLSDIGTY 118

Query: 108 TCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWF 167
            C V +  G      K+ L+VLV PS     +  S  IG+   + C  ++GS P +Y W 
Sbjct: 119 QCKVKKAPG--VANKKIHLVVLVKPSGARCYVDGSEEIGSDFKIKCEPKEGSLPLQYEWQ 176

Query: 168 K--DGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSN 225
           K  D   MPT           S++   T+  +     S+  +G YSC  RN  G+     
Sbjct: 177 KLSDSQKMPT-----------SWLAEMTSSVISVKNASSEYSGTYSCTVRNRVGSDQCLL 225

Query: 226 AVRMEAVERNVGVIVAAVLVTLI---LLGILVF 255
            + +       G+I  A++ TL+   L+G+++F
Sbjct: 226 RLNVVPPSNKAGLIAGAIIGTLLALALIGLIIF 258


>gi|61966777 V-set and immunoglobulin domain containing 8 [Homo
           sapiens]
          Length = 414

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 74/283 (26%), Positives = 108/283 (38%), Gaps = 47/283 (16%)

Query: 16  ILAILLCSLALGSVTVHSSEPEVR-IPENNPVKLSCAYS------GFSSPRVEWKFDQGD 68
           +L + L    L +V ++    EV  + E + V+L C Y       G +   +EW     D
Sbjct: 9   LLLVCLSPALLSAVRINGDGQEVLYLAEGDNVRLGCPYVLDPEDYGPNGLDIEWMQVNSD 68

Query: 69  TTRLVCYNNKITASYED-------------RVTFLPT-------GITFKSVTREDTGTYT 108
                 +   +  SY+D             RV F  +        I   ++   DT TY 
Sbjct: 69  PAH---HRENVFLSYQDKRINHGSLPHLQQRVRFAASDPSQYDASINLMNLQVSDTATYE 125

Query: 109 CMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFK 168
           C V +    +    KV + V   P+ P        T GN  VL C    GS P  Y W K
Sbjct: 126 CRVKK---TTMATRKVIVTVQARPAVPMCWTEGHMTYGNDVVLKCYASGGSQPLSYKWAK 182

Query: 169 -DGIVMP------------TNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
             G   P             +  S +   +SS       G+LV   +S +D G Y C   
Sbjct: 183 ISGHHYPYRAGSYTSQHSYHSELSYQESFHSSINQGLNNGDLVLKDISRADDGLYQCTVA 242

Query: 216 NGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIW 258
           N  G  +    V++ +  R +GVI+  VL +L+ LG L  GIW
Sbjct: 243 NNVGYSVCVVEVKV-SDSRRIGVIIGIVLGSLLALGCLAVGIW 284


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 53/193 (27%), Positives = 80/193 (41%), Gaps = 32/193 (16%)

Query: 29  VTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYED-RV 87
           V++H+S       +   VK+SC+ SG+ +P + W             + +  A  ED R+
Sbjct: 493 VSIHTSSQH--FSQGVEVKVSCSASGYPTPHISW-------------SRESQALQEDSRI 537

Query: 88  TFLPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIG 146
                G +  + V  ED G Y+C  + E G    +  V L    PPS   VN      +G
Sbjct: 538 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD--QETVTLYYTDPPSVSAVNAVVLVAVG 595

Query: 147 NRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASD 206
             AVL C E  G PP    W++ G+ M   P+ +            ++G+L        D
Sbjct: 596 EEAVLVC-EASGVPPPRVIWYRGGLEMILAPEGS------------SSGKLRIPAAQERD 642

Query: 207 TGEYSCEARNGYG 219
            G Y+C A N  G
Sbjct: 643 AGTYTCRAVNELG 655



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 73/297 (24%), Positives = 115/297 (38%), Gaps = 51/297 (17%)

Query: 24  LALGSVTVHSSEP-EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITAS 82
           LA+G     +  P +V +       L+C  +G   P V W+   G    L     ++ A 
Sbjct: 663 LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-----RLGAG 717

Query: 83  YEDRVTFLPTGITF-KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPS 141
              R     +G+ F +SV  ED   Y C    E  N +G+V+ +  ++V    P     S
Sbjct: 718 RGSRSRQPDSGVLFFESVAPEDQAPYVC----EARNVFGKVQAEARLIVTGHAPPQIASS 773

Query: 142 SATI----GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPK-STRAFSNSSYVLNPTTGE 196
           + T+    G    L C    G P  E  W KDG  +P   + S RA            G 
Sbjct: 774 APTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA-----------DGS 822

Query: 197 LVFDPLSASDTGEYSCEARNGYGT----------------PMTSNAVRMEAVERNVGVIV 240
           L  D       G YSC A N  G+                P  ++ +  E V  ++  + 
Sbjct: 823 LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVA 882

Query: 241 AAVLVTLILLGILVFGIWFAYSRG-HFDRTKKGTSSKKVIYSQPSARSEGEFKQTSS 296
           + V    I        +    SRG H++ +K+GT    ++ +QPSA+  G +  T++
Sbjct: 883 SGVPAPTITWTKETNAL---TSRGPHYNVSKEGT----LLIAQPSAQDAGAYVCTAT 932



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 47/176 (26%), Positives = 68/176 (38%), Gaps = 27/176 (15%)

Query: 48  LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
           L C  SG   PRV W   +G    ++      +             +   +    D GTY
Sbjct: 600 LVCEASGVPPPRVIWY--RGGLEMILAPEGSSSGK-----------LRIPAAQERDAGTY 646

Query: 108 TCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI--GNRAVLTCSEQDGSPPSEYT 165
           TC    E G++  E+++     V  +     +P   T+  G  A+L C    G PP   T
Sbjct: 647 TCRAVNELGDASAEIQLA----VGHAPQLTELPRDVTVELGRSALLAC-RATGRPPPTVT 701

Query: 166 WFK-DGIVMPTNPKSTR-AFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           W + DG      P   R      S    P +G L F+ ++  D   Y CEARN +G
Sbjct: 702 WRRGDG-----QPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFG 752



 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 51/189 (26%), Positives = 70/189 (37%), Gaps = 35/189 (18%)

Query: 42   ENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTR 101
            E  P  L C  SG  +P + W     +T  L         S E         +     + 
Sbjct: 872  EGVPASLPCVASGVPAPTITWT---KETNALTSRGPHYNVSKEGT-------LLIAQPSA 921

Query: 102  EDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTV--------NIPSSATI--GNRAVL 151
            +D G Y C  +   G S  E+++ +      +KP +        N+P   T   G    L
Sbjct: 922  QDAGAYVCTATNTVGFSSQEMRLSV-----NTKPRIHMNGSRNANVPLQVTAKAGEEVTL 976

Query: 152  TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
             C E  GSPP   TW KD    P  P + R      Y L P +G L    +   D+G Y 
Sbjct: 977  DC-EAKGSPPPLVTWTKDS--RPVPPITNR------YGLLP-SGSLRLAQVQVGDSGHYE 1026

Query: 212  CEARNGYGT 220
            C A N  G+
Sbjct: 1027 CTASNPAGS 1035



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 35/127 (27%), Positives = 51/127 (40%), Gaps = 16/127 (12%)

Query: 100 TREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSK--PTVNIPSSATIGNRAVLTCSEQD 157
           ++ + GTY C      G   G  K +++V  PP +  P  N+  S   G  AVL+C    
Sbjct: 370 SKAEEGTYECTAVSRAGT--GRAKAQIVVTDPPPQLVPAPNVTVSP--GETAVLSCRVL- 424

Query: 158 GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
           G  P   TW +D  V+P +       ++ S         L    +  +D G Y C A N 
Sbjct: 425 GEAPYNLTWVRDWRVLPASTGRVAQLADLS---------LEISGIIPTDGGRYQCVASNA 475

Query: 218 YGTPMTS 224
            G    S
Sbjct: 476 NGVTRAS 482



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 43/189 (22%), Positives = 74/189 (39%), Gaps = 31/189 (16%)

Query: 36  PEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPT-GI 94
           P V +       LSC   G +   + W  D            ++  +   RV  L    +
Sbjct: 407 PNVTVSPGETAVLSCRVLGEAPYNLTWVRDW-----------RVLPASTGRVAQLADLSL 455

Query: 95  TFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAV---L 151
               +   D G Y C+ S    N+ G  +  + +LV  + P V+I +S+   ++ V   +
Sbjct: 456 EISGIIPTDGGRYQCVAS----NANGVTRASVWLLVREA-PQVSIHTSSQHFSQGVEVKV 510

Query: 152 TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
           +CS   G P    +W ++          ++A    S +     G L+   ++  D G YS
Sbjct: 511 SCSAS-GYPTPHISWSRE----------SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 559

Query: 212 CEARNGYGT 220
           C+A N  GT
Sbjct: 560 CQATNEVGT 568


>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
           sapiens]
          Length = 790

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 53/193 (27%), Positives = 80/193 (41%), Gaps = 32/193 (16%)

Query: 29  VTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYED-RV 87
           V++H+S       +   VK+SC+ SG+ +P + W             + +  A  ED R+
Sbjct: 609 VSIHTSSQH--FSQGVEVKVSCSASGYPTPHISW-------------SRESQALQEDSRI 653

Query: 88  TFLPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIG 146
                G +  + V  ED G Y+C  + E G    +  V L    PPS   VN      +G
Sbjct: 654 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD--QETVTLYYTDPPSVSAVNAVVLVAVG 711

Query: 147 NRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASD 206
             AVL C E  G PP    W++ G+ M   P+ +            ++G+L        D
Sbjct: 712 EEAVLVC-EASGVPPPRVIWYRGGLEMILAPEGS------------SSGKLRIPAAQERD 758

Query: 207 TGEYSCEARNGYG 219
            G Y+C A N  G
Sbjct: 759 AGTYTCRAVNELG 771



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 35/127 (27%), Positives = 51/127 (40%), Gaps = 16/127 (12%)

Query: 100 TREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSK--PTVNIPSSATIGNRAVLTCSEQD 157
           ++ + GTY C      G   G  K +++V  PP +  P  N+  S   G  AVL+C    
Sbjct: 486 SKAEEGTYECTAVSRAGT--GRAKAQIVVTDPPPQLVPAPNVTVSP--GETAVLSCRVL- 540

Query: 158 GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
           G  P   TW +D  V+P +       ++ S         L    +  +D G Y C A N 
Sbjct: 541 GEAPYNLTWVRDWRVLPASTGRVAQLADLS---------LEISGIIPTDGGRYQCVASNA 591

Query: 218 YGTPMTS 224
            G    S
Sbjct: 592 NGVTRAS 598



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 43/189 (22%), Positives = 74/189 (39%), Gaps = 31/189 (16%)

Query: 36  PEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPT-GI 94
           P V +       LSC   G +   + W  D            ++  +   RV  L    +
Sbjct: 523 PNVTVSPGETAVLSCRVLGEAPYNLTWVRDW-----------RVLPASTGRVAQLADLSL 571

Query: 95  TFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAV---L 151
               +   D G Y C+ S    N+ G  +  + +LV  + P V+I +S+   ++ V   +
Sbjct: 572 EISGIIPTDGGRYQCVAS----NANGVTRASVWLLVREA-PQVSIHTSSQHFSQGVEVKV 626

Query: 152 TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
           +CS   G P    +W ++          ++A    S +     G L+   ++  D G YS
Sbjct: 627 SCSAS-GYPTPHISWSRE----------SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 675

Query: 212 CEARNGYGT 220
           C+A N  GT
Sbjct: 676 CQATNEVGT 684


>gi|32699028 V-set and immunoglobulin domain containing 1 [Homo
           sapiens]
          Length = 387

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 74/296 (25%), Positives = 119/296 (40%), Gaps = 50/296 (16%)

Query: 16  ILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPR----VEWKF------- 64
           IL+ L   +++  VT+      V +  N  V L C Y+   + R    ++W F       
Sbjct: 11  ILSCLAGQVSVVQVTIPDGFVNVTVGSN--VTLICIYTTTVASREQLSIQWSFFHKKEME 68

Query: 65  -------DQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEG-- 115
                    G    +  + ++IT S +         IT   +   D+G Y C V+     
Sbjct: 69  PISIYFSQGGQAVAIGQFKDRITGSNDPG----NASITISHMQPADSGIYICDVNNPPDF 124

Query: 116 -GNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFK----DG 170
            G + G + V   VLV PSKP  ++      G+   L+C    G+P   Y W K    D 
Sbjct: 125 LGQNQGILNVS--VLVKPSKPLCSVQGRPETGHTISLSCLSALGTPSPVYYWHKLEGRDI 182

Query: 171 IVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRME 230
           + +  N              NPTTG LV   L+  + G Y C A N  G   +S  + + 
Sbjct: 183 VPVKEN-------------FNPTTGILVIGNLTNFEQGYYQCTAINRLGN--SSCEIDLT 227

Query: 231 AVERNVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSAR 286
           +    VG+IV A++ +L+   I++  + FA  R       K  +SK +   +P  +
Sbjct: 228 SSHPEVGIIVGALIGSLVGAAIIISVVCFA--RNKAKAKAKERNSKTIAELEPMTK 281


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 66/244 (27%), Positives = 98/244 (40%), Gaps = 35/244 (14%)

Query: 42   ENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTR 101
            +   ++L C  SG    +V W  +  +      YN     S+ + V  L    T    + 
Sbjct: 6378 QGESIQLECKISGSPEIKVSWFRNDSELHESWKYN----MSFINSVALL----TINEASA 6429

Query: 102  EDTGTYTCMVSEEGGNSYGEVKVK--LIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGS 159
            ED+G Y C    E  N  G+      L V  PP       P  A  G+  +L C E  G+
Sbjct: 6430 EDSGDYIC----EAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQC-EISGT 6484

Query: 160  PPSEYTWFKDGIVMPTNPK---STRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
            PP E  W KD   +  + K   +++ F  S ++LN          L ASD GEY C+A N
Sbjct: 6485 PPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILN----------LEASDVGEYHCKATN 6534

Query: 217  GYGTPMTSNAVRMEAVERNV-------GVIVAAVLVTLILLGILVFGIWFAYSRGHFDRT 269
              G+   S +V+ +   R V        +I  AV +  I+ G     + +   RG   R 
Sbjct: 6535 EVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRE 6594

Query: 270  KKGT 273
             + T
Sbjct: 6595 SENT 6598



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 52/194 (26%), Positives = 85/194 (43%), Gaps = 22/194 (11%)

Query: 40   IPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSV 99
            +   +P+ L   Y+G     V W  D+     L+  + + + +  ++ T L         
Sbjct: 6938 VETGSPIVLEATYTGTPPISVSWIKDE----YLISQSERCSITMTEKSTILE----ILES 6989

Query: 100  TREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS--KPTVNIPSSATIGNRAVLTCSEQD 157
            T ED   Y+C++  E G    E  V   VL PP   +P  ++   A IG  A L C + D
Sbjct: 6990 TIEDYAQYSCLIENEAGQDICEALVS--VLEPPYFIEPLEHV--EAVIGEPATLQC-KVD 7044

Query: 158  GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
            G+P    +W+K+   + + P     F N+          LV + +  SD GEYSC+A N 
Sbjct: 7045 GTPEIRISWYKEHTKLRSAPAYKMQFKNN-------VASLVINKVDHSDVGEYSCKADNS 7097

Query: 218  YGTPMTSNAVRMEA 231
             G   +S  + ++A
Sbjct: 7098 VGAVASSAVLVIKA 7111



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 54/196 (27%), Positives = 92/196 (46%), Gaps = 20/196 (10%)

Query: 57   SPRVEWKFDQGDTTRLVCYNNK--ITASYEDRVTFLPTG--ITFKSVTREDTGTYTCMVS 112
            S R+E K       R+V + N+  + AS + R+TF+ +   I   +++ ED+G + C   
Sbjct: 5440 SSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQ 5499

Query: 113  EEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIV 172
               G++      K+IV  PP   +   P   T+ N  V    E  G+PP E  W+KD   
Sbjct: 5500 NPAGST--SCSTKVIVKEPPVFSSFP-PIVETLKNAEVSLECELSGTPPFEVVWYKDKRQ 5556

Query: 173  MPTNPK---STRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRM 229
            + ++ K   +++ F  S ++LN  T          SD GEY C+A+N  G+      V++
Sbjct: 5557 LRSSKKYKIASKNFHTSIHILNVDT----------SDIGEYHCKAQNEVGSDTCVCTVKL 5606

Query: 230  EAVERNVGVIVAAVLV 245
            +   R V  + +  +V
Sbjct: 5607 KEPPRFVSKLNSLTVV 5622



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 51/199 (25%), Positives = 81/199 (40%), Gaps = 24/199 (12%)

Query: 32   HSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLP 91
            HS EP         + L   Y+G     V WK D  + T     + K      ++   L 
Sbjct: 5995 HSVEP------GKSIILESTYTGTLPISVTWKKDGFNITT----SEKCNIVTTEKTCILE 6044

Query: 92   TGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVL 151
                  + T+ D G Y+C +  E G       V    L PP   T   P  A +G+   L
Sbjct: 6045 ----ILNSTKRDAGQYSCEIENEAGRDVCGALVS--TLEPPYFVTELEPLEAAVGDSVSL 6098

Query: 152  TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
             C +  G+P    +W+K    +   P+    F+N+          LVF+ ++ +D+GEY+
Sbjct: 6099 QC-QVAGTPEITVSWYKGDTKLRPTPEYRTYFTNN-------VATLVFNKVNINDSGEYT 6150

Query: 212  CEARNGYGTPMTSNAVRME 230
            C+A N  GT  +    R++
Sbjct: 6151 CKAENSIGTASSKTVFRIQ 6169



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 61/216 (28%), Positives = 88/216 (40%), Gaps = 35/216 (16%)

Query: 31   VHSSEPEVRIPENNP--------VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITAS 82
            V + EP   + E  P        V L C  +G     V W   +GDT        + T  
Sbjct: 6073 VSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWY--KGDTKL------RPTPE 6124

Query: 83   YEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLV-----PPSKPTV 137
            Y    T     + F  V   D+G YTC       NS G    K +  +     PPS    
Sbjct: 6125 YRTYFTNNVATLVFNKVNINDSGEYTCKAE----NSIGTASSKTVFRIQERQLPPSFARQ 6180

Query: 138  NIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGEL 197
                  T+G    LTC   +GS P +  W++DG+++  +         +S+V N  T ++
Sbjct: 6181 LKDIEQTVGLPVTLTC-RLNGSAPIQVCWYRDGVLLRDDENL-----QTSFVDNVATLKI 6234

Query: 198  VFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVE 233
            +   LS S  G+YSC A N  GT   S++ R+ A E
Sbjct: 6235 LQTDLSHS--GQYSCSASNPLGT--ASSSARLTARE 6266



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 55/222 (24%), Positives = 89/222 (40%), Gaps = 28/222 (12%)

Query: 22   CSLALGSVT----VHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNN 77
            CS  LG       +   EP   + ++   +  C   G    +V W  D+ +       ++
Sbjct: 7295 CSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQE----SS 7350

Query: 78   KITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTV 137
            K   S+ D V  L       +++ ED+G YTC      G++     +K  V  PP     
Sbjct: 7351 KFRMSFVDSVAVLE----MHNLSVEDSGDYTCEAHNAAGSASSSTSLK--VKEPPIFRKK 7404

Query: 138  NIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPK---STRAFSNSSYVLNPTT 194
              P     G    L C E  G+PP   +W+KD   + +  K    +  F  S ++LN   
Sbjct: 7405 PHPIETLKGADVHLEC-ELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILN--- 7460

Query: 195  GELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNV 236
                   + A+D GEY C+A N  G+     ++ ++A  R V
Sbjct: 7461 -------VDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFV 7495



 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 66/244 (27%), Positives = 97/244 (39%), Gaps = 30/244 (12%)

Query: 31   VHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFL 90
            +   EP + +   NP  L C  +G      +W  D            +++A  +  +TF+
Sbjct: 6648 IEKPEP-MTVTTGNPFALECVVTGTPELSAKWFKD----------GRELSADSKHHITFI 6696

Query: 91   PTGITFKSVTRE--DTGTYTCMVSEEGGNSYGEVKVKLIV-LVPPSKPTVNIPSSATIGN 147
                + K    E  D G Y+  V    G S   V V +   +VPPS        +A +G 
Sbjct: 6697 NKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGA 6756

Query: 148  RAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDT 207
              VL C    GS P    WF+DG  + + PK   +FS +   LN          L  SDT
Sbjct: 6757 SVVLEC-RVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLN-------LSLLEPSDT 6808

Query: 208  GEYSCEARNGYGTPMTSNAVRM------EAVERNVGVIVAAVLV-TLILLGILVFGI-WF 259
            G Y+C A N  G+   S  + +      E    +V V+    L  T ++ G   F + WF
Sbjct: 6809 GIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWF 6868

Query: 260  AYSR 263
              SR
Sbjct: 6869 KGSR 6872



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 59/217 (27%), Positives = 89/217 (41%), Gaps = 31/217 (14%)

Query: 25   ALGSVTVHSSEPEVRIPENNPVKL---------SCAYSGFSSPRVEWKFDQGDTTRLVCY 75
            A    T+   EP   I + +PV +          C  +G    RV W  D          
Sbjct: 4849 ATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLD---------- 4898

Query: 76   NNKITASYEDRVTFLPTGITFK--SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS 133
             N+ITA  +  ++F+    TF+      E++GTY C    + G +   +++K  V  PP+
Sbjct: 4899 GNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELK--VKEPPT 4956

Query: 134  KPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPT 193
                  P      +   L C E  G+PP E TW K+   + ++ K T     S + L+ T
Sbjct: 4957 FIRELKPVEVVKYSDVELEC-EVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHIT 5015

Query: 194  TGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRME 230
                  DP   SDTGEY C   N  G+   S  V ++
Sbjct: 5016 K----CDP---SDTGEYQCIVSNEGGSCSCSTRVALK 5045



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 46/194 (23%), Positives = 84/194 (43%), Gaps = 17/194 (8%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
            V + E +P+ L C  +G    +V+W  D     + +  +   + S+E+ V         +
Sbjct: 5150 VDVTEKDPMTLECVVAGTPELKVKWLKD----GKQIVPSRYFSMSFENNV----ASFRIQ 5201

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLI-VLVPPSKPTVNIPSSATIGNRAVLTCSEQ 156
            SV ++D+G YT  V  + G+S  +  ++++   +PPS           +G+   + C + 
Sbjct: 5202 SVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMEC-KV 5260

Query: 157  DGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
             GS P    WFKDG  + T+ K          V +  +  L  + L   DT  Y+C+  N
Sbjct: 5261 SGSLPISAQWFKDGKEISTSAK-------YRLVCHERSVSLEVNNLELEDTANYTCKVSN 5313

Query: 217  GYGTPMTSNAVRME 230
              G    S  + ++
Sbjct: 5314 VAGDDACSGILTVK 5327



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 49/184 (26%), Positives = 75/184 (40%), Gaps = 36/184 (19%)

Query: 46   VKLSCAYSGFSSPRVEWKFDQGDTT-----RLVCYNNKITASYEDRVTFLPTGITFKSVT 100
            + + C  SG      +W  D  + +     RLVC+   ++             +   ++ 
Sbjct: 5254 IHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVS-------------LEVNNLE 5300

Query: 101  REDTGTYTCMVSEEGGNSYGE----VKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQ 156
             EDT  YTC VS   G+        VK     LV P +    IP S T+  +A+L     
Sbjct: 5301 LEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQA-IPDS-TVEFKAILK---- 5354

Query: 157  DGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
             G+PP +  WFKD + + + PK       S+  LN          + AS TG+Y+C   N
Sbjct: 5355 -GTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLN-------LYSVDASKTGQYTCHVTN 5406

Query: 217  GYGT 220
              G+
Sbjct: 5407 DVGS 5410



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 60/206 (29%), Positives = 89/206 (43%), Gaps = 19/206 (9%)

Query: 83   YEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS 142
            +ED++  L   +       +D+GTY C  S E G+S       + V  PPS      PS 
Sbjct: 3694 FEDKIATLEIPLA----KLKDSGTYVCTASNEAGSS--SCSATVTVREPPSFVKKVDPSY 3747

Query: 143  ATI-GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDP 201
              + G  A L C +  GSP  + TWFK+   +  +      F NS  +L+ T        
Sbjct: 3748 LMLPGESARLHC-KLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDIT-------D 3799

Query: 202  LSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLV--TLILLGILVFGIWF 259
            +   D+G YSCEA N  G+   S  + ++     +  +  A +V  T  LL   V G   
Sbjct: 3800 VKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTG- 3858

Query: 260  AYSRGHFDRTKKGTSSKKV-IYSQPS 284
             +    F   K+  SSKK  ++SQ S
Sbjct: 3859 PFEISWFKDKKQIRSSKKYRLFSQKS 3884



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 49/202 (24%), Positives = 81/202 (40%), Gaps = 24/202 (11%)

Query: 31   VHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFL 90
            V   EP   + + +  +L+C  +G    ++ W             + +I  S + R++F+
Sbjct: 4302 VEKLEPSQLLKKGDATQLACKVTGTPPIKITW----------FANDREIKESSKHRMSFV 4351

Query: 91   PTGITFK--SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKP-TVNIPSSATIGN 147
             +    +   V  ED+G Y C    E G+ +       IV+V  S   T        +  
Sbjct: 4352 ESTAVLRLTDVGIEDSGEYMCEAQNEAGSDH----CSSIVIVKESPYFTKEFKPIEVLKE 4407

Query: 148  RAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDT 207
              V+  +E  G+PP E TWFKD  ++ +  K  + F     V       L      A+D 
Sbjct: 4408 YDVMLLAEVAGTPPFEITWFKDNTILRSGRK-YKTFIQDHLV------SLQILKFVAADA 4460

Query: 208  GEYSCEARNGYGTPMTSNAVRM 229
            GEY C   N  G+ + S  V +
Sbjct: 4461 GEYQCRVTNEVGSSICSARVTL 4482



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 46/191 (24%), Positives = 78/191 (40%), Gaps = 18/191 (9%)

Query: 40   IPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSV 99
            I +  P+ L   ++G     V WK +  + T     N  IT + +  +  +P      S 
Sbjct: 7879 IEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCN--ITTTEKSAILEIP------SS 7930

Query: 100  TREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGS 159
            T ED G Y C +    G        ++++L PP       P   ++G+ A L C +  G+
Sbjct: 7931 TVEDAGQYNCYIENASGKD--SCSAQILILEPPYFVKQLEPVKVSVGDSASLQC-QLAGT 7987

Query: 160  PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            P    +W+K    +         F N+          LVF+ +  +D+GEY C+A N  G
Sbjct: 7988 PEIGVSWYKGDTKLRPTTTYKMHFRNN-------VATLVFNQVDINDSGEYICKAENSVG 8040

Query: 220  TPMTSNAVRME 230
                S  + ++
Sbjct: 8041 EVSASTFLTVQ 8051



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 46/166 (27%), Positives = 76/166 (45%), Gaps = 27/166 (16%)

Query: 81   ASYEDRVTFLPTG---ITFKSVT---------REDTGTYTCMVSEEGGNSYGEVKVKLIV 128
            A Y++ +   PT    ITFK+ T           D G YTC VS + G++   +    IV
Sbjct: 8282 AWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSA---LCTSSIV 8338

Query: 129  LVPPSKPTVN----IPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFS 184
            +  P KP V      P + + G    L+C  Q GS P    W K G  +  + + + +F+
Sbjct: 8339 IKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQ-GSEPIRIQWLKAGREIKPSDRCSFSFA 8397

Query: 185  NSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRME 230
            + + VL           ++ +D+G+Y C+A N  G+  T + V ++
Sbjct: 8398 SGTAVLE-------LRDVAKADSGDYVCKASNVAGSDTTKSKVTIK 8436



 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 54/199 (27%), Positives = 79/199 (39%), Gaps = 26/199 (13%)

Query: 31   VHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFL 90
            V   EP V++   +   L C  +G     V W   +GDT        + T +Y+      
Sbjct: 7964 VKQLEP-VKVSVGDSASLQCQLAGTPEIGVSWY--KGDTKL------RPTTTYKMHFRNN 8014

Query: 91   PTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLV-----PPSKPTVNIPSSATI 145
               + F  V   D+G Y C       NS GEV     + V     PPS          T+
Sbjct: 8015 VATLVFNQVDINDSGEYICKAE----NSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETV 8070

Query: 146  GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSAS 205
            G   V  C+   GS P   +W+KDG  +  +P    +F +++  LN      +F     S
Sbjct: 8071 GLPVVFDCAIS-GSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLN------IF-KTDRS 8122

Query: 206  DTGEYSCEARNGYGTPMTS 224
              G+YSC A N  G+  +S
Sbjct: 8123 LAGQYSCTATNPIGSASSS 8141



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 41/138 (29%), Positives = 58/138 (42%), Gaps = 9/138 (6%)

Query: 90   LPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRA 149
            L + +    V   D+GTYTC VS   G    E    L V  P +      PS       A
Sbjct: 4259 LESSLELYLVKTSDSGTYTCKVSNVAGGV--ECSANLFVKEPATFVEKLEPSQLLKKGDA 4316

Query: 150  VLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGE 209
                 +  G+PP + TWF +   +  + K   +F  S+ VL  T        +   D+GE
Sbjct: 4317 TQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLT-------DVGIEDSGE 4369

Query: 210  YSCEARNGYGTPMTSNAV 227
            Y CEA+N  G+   S+ V
Sbjct: 4370 YMCEAQNEAGSDHCSSIV 4387



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 48/182 (26%), Positives = 74/182 (40%), Gaps = 18/182 (9%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
            V + + + V+L C  +G     V W        R +  + K T +  DRV+     IT  
Sbjct: 4964 VEVVKYSDVELECEVTGTPPFEVTWL----KNNREIRSSKKYTLT--DRVSVFNLHIT-- 5015

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQD 157
                 DTG Y C+VS EGG+     +V    L  P      I ++ T+   +    S   
Sbjct: 5016 KCDPSDTGEYQCIVSNEGGSCSCSTRV---ALKEPPSFIKKIENTTTVLKSSATFQSTVA 5072

Query: 158  GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
            GSPP   TW KD  ++  +     +F +S          L    +    +G Y+C+A+N 
Sbjct: 5073 GSPPISITWLKDDQILDEDDNVYISFVDS-------VATLQIRSVDNGHSGRYTCQAKNE 5125

Query: 218  YG 219
             G
Sbjct: 5126 SG 5127



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 45/191 (23%), Positives = 79/191 (41%), Gaps = 17/191 (8%)

Query: 30   TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTF 89
            T+      + + + +P  L   +SG      +W  D  + T        + + Y+  VT 
Sbjct: 4580 TITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELT--------LGSKYKISVTD 4631

Query: 90   LPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI-GNR 148
              + +   S  ++D+G YT  V  + G S  + ++ ++ L+ P   T  +    +I G+ 
Sbjct: 4632 TVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSF 4691

Query: 149  AVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTG 208
              L C    GS P    WFKD   +  + K   +F ++       T  L    L  +D+G
Sbjct: 4692 IDLECIVA-GSHPISIQWFKDDQEISASEKYKFSFHDN-------TAFLEISQLEGTDSG 4743

Query: 209  EYSCEARNGYG 219
             Y+C A N  G
Sbjct: 4744 TYTCSATNKAG 4754



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 52/195 (26%), Positives = 79/195 (40%), Gaps = 25/195 (12%)

Query: 35   EPEVRIPENNPVK--------LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDR 86
            EP V + +  P+         L C  +G     VEW  D     +L+  + K   S+ ++
Sbjct: 5702 EPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDG----KLLTSSQKHKFSFYNK 5757

Query: 87   VTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLI-VLVPPSKPTVNIPSSATI 145
            ++ L       SV R+D GTYT  V    G S     V +    VPPS       +   +
Sbjct: 5758 ISSL----RILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVL 5813

Query: 146  GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSAS 205
            G   +L C +  GS P    WF +   + +  K    FS++   L         + L +S
Sbjct: 5814 GASCILEC-KVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQ-------LNSLDSS 5865

Query: 206  DTGEYSCEARNGYGT 220
            D G Y+C A N  G+
Sbjct: 5866 DMGNYTCVAANVAGS 5880



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 47/188 (25%), Positives = 72/188 (38%), Gaps = 29/188 (15%)

Query: 50   CAYSGFSSPRVEWKFDQ-----GDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDT 104
            C  +G    R+ W  D      G    + C  N                +    V + D+
Sbjct: 6292 CHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNT-------------PHLRILKVGKGDS 6338

Query: 105  GTYTCMVSEEGGNSYGEVKVKLIVLVPPS-KPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
            G YTC  + + G        +L V  PP     +     A  G    L C +  GSP  +
Sbjct: 6339 GQYTCQATNDVGKDM--CSAQLSVKEPPKFVKKLEASKVAKQGESIQLEC-KISGSPEIK 6395

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMT 223
             +WF++   +  + K   +F NS  +L         +  SA D+G+Y CEA NG G    
Sbjct: 6396 VSWFRNDSELHESWKYNMSFINSVALLT-------INEASAEDSGDYICEAHNGVGDASC 6448

Query: 224  SNAVRMEA 231
            S A+ ++A
Sbjct: 6449 STALTVKA 6456



 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 50/176 (28%), Positives = 75/176 (42%), Gaps = 21/176 (11%)

Query: 46   VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
            V+L     G     V W  D+G+  R    ++ I  SY + +  L     F  V   + G
Sbjct: 7509 VQLQTTIEGAEPISVVWFKDKGEIVR---ESDNIWISYSENIATLQ----FSRVEPANAG 7561

Query: 106  TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS--ATIGNRAVLTCSEQDGSPPSE 163
             YTC +  + G    E    L VL P +   V  P S   T G+   L C+   G+P   
Sbjct: 7562 KYTCQIKNDAGMQ--ECFATLSVLEPAT--IVEKPESIKVTTGDTCTLECTVA-GTPELS 7616

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              WFKDG  + ++ K   +F       N  +G  + + ++ SD+G YS E +N  G
Sbjct: 7617 TKWFKDGKELTSDNKYKISF------FNKVSGLKIIN-VAPSDSGVYSFEVQNPVG 7665



 Score = 51.6 bits (122), Expect = 8e-07
 Identities = 47/196 (23%), Positives = 80/196 (40%), Gaps = 17/196 (8%)

Query: 26   LGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYED 85
            L   T+      +++   +   L C  +G      +W  D  + T     +NK   S+ +
Sbjct: 7583 LEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTS----DNKYKISFFN 7638

Query: 86   RVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIV-LVPPSKPTVNIPSSAT 144
            +V+    G+   +V   D+G Y+  V    G       +++    VPPS       ++  
Sbjct: 7639 KVS----GLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGL 7694

Query: 145  IGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSA 204
             G+  V+ C    GSPP   +WF +G        S R +  +   L   T  L  + L  
Sbjct: 7695 SGSSVVMECKVY-GSPPISVSWFHEG----NEISSGRKYQTT---LTDNTCALTVNMLEE 7746

Query: 205  SDTGEYSCEARNGYGT 220
            SD+G+Y+C A N  G+
Sbjct: 7747 SDSGDYTCIATNMAGS 7762



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 48/193 (24%), Positives = 80/193 (41%), Gaps = 21/193 (10%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
            +++   +P  L    +G    + +W  D     R +  + K   S+++ V  L     F 
Sbjct: 4026 IQVTAGDPATLEYTVAGTPELKPKWYKDG----RPLVASKKYRISFKNNVAQLK----FY 4077

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVL-VPP--SKPTVNIPSSATIGNRAVLTCS 154
            S    D+G YT  +S E G+S  E    ++   + P  +KP  N+ S   +     L C 
Sbjct: 4078 SAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDS--VVNGTCRLDCK 4135

Query: 155  EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
               GS P   +WFKDG  +  + +   AF          T  L    +  +D G ++C A
Sbjct: 4136 IA-GSLPMRVSWFKDGKEIAASDRYRIAFVEG-------TASLEIIRVDMNDAGNFTCRA 4187

Query: 215  RNGYGTPMTSNAV 227
             N  G+  +S A+
Sbjct: 4188 TNSVGSKDSSGAL 4200



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 45/172 (26%), Positives = 66/172 (38%), Gaps = 18/172 (10%)

Query: 48   LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
            L C  +G S   V W  ++   T++V    K   ++ D V  L       S+   D G Y
Sbjct: 5819 LECKVAGSSPISVAWFHEK---TKIVS-GAKYQTTFSDNVCTLQ----LNSLDSSDMGNY 5870

Query: 108  TCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWF 167
            TC+ +   G+   E +  L V  PPS      P     G     T S   G+PP +  WF
Sbjct: 5871 TCVAANVAGSD--ECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFT-SVIRGTPPFKVNWF 5927

Query: 168  KDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            +    +    +    F +       T  EL    +  S +GEY+C   N  G
Sbjct: 5928 RGARELVKGDRCNIYFED-------TVAELELFNIDISQSGEYTCVVSNNAG 5972



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 44/185 (23%), Positives = 75/185 (40%), Gaps = 25/185 (13%)

Query: 45   PVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDT 104
            P  L C   G    R+ W  +    T+L     +   +Y+ +       +    V   D 
Sbjct: 7036 PATLQCKVDGTPEIRISWYKEH---TKL-----RSAPAYKMQFKNNVASLVINKVDHSDV 7087

Query: 105  GTYTCMVSEEGGNSYGEVKVKLIVLV-----PPSKPTVNIPSSATIGNRAVLTCSEQDGS 159
            G Y+C    +  NS G V    ++++     PP           T+G      C   +GS
Sbjct: 7088 GEYSC----KADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFEC-RINGS 7142

Query: 160  PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
             P + +W+KDG+++  +     A   +S+V N  T +++      S  G+Y+C A N  G
Sbjct: 7143 EPLQVSWYKDGVLLKDD-----ANLQTSFVHNVATLQIL--QTDQSHIGQYNCSASNPLG 7195

Query: 220  TPMTS 224
            T  +S
Sbjct: 7196 TASSS 7200



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 9/137 (6%)

Query: 94   ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTC 153
            +T   V + D G YTC  S   G        +L V  PP       PS     +      
Sbjct: 7269 LTVLKVGKGDAGQYTCYASNIAGKD--SCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYE 7326

Query: 154  SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCE 213
             +  GSP  +  W+KD   +  + K   +F +S  VL           LS  D+G+Y+CE
Sbjct: 7327 CKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLE-------MHNLSVEDSGDYTCE 7379

Query: 214  ARNGYGTPMTSNAVRME 230
            A N  G+  +S +++++
Sbjct: 7380 AHNAAGSASSSTSLKVK 7396



 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 36/121 (29%), Positives = 53/121 (43%), Gaps = 16/121 (13%)

Query: 103  DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNI--PSSAT--IGNRAVLTCSEQDG 158
            D G YTC  S    N YG V     + V  + P   +  P S T  +G  A   C+   G
Sbjct: 3522 DCGEYTCKAS----NEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVT-G 3576

Query: 159  SPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGY 218
            +P  E  W KDG  +  +P    + + + ++L  +        L+  D G YSC+A N +
Sbjct: 3577 TPVIETIWQKDGAALSPSPNWRISDAENKHILELSN-------LTIQDRGVYSCKASNKF 3629

Query: 219  G 219
            G
Sbjct: 3630 G 3630



 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 44/176 (25%), Positives = 68/176 (38%), Gaps = 20/176 (11%)

Query: 46   VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
            + L C  +G     ++W  D  +    +  + K   S+ D   FL        +   D+G
Sbjct: 4692 IDLECIVAGSHPISIQWFKDDQE----ISASEKYKFSFHDNTAFLE----ISQLEGTDSG 4743

Query: 106  TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIG-NRAVLTCSEQDGSPPSEY 164
            TYTC  + + G  + +    L V  PP    V  P S  +  N  V   +   G+ P   
Sbjct: 4744 TYTCSATNKAG--HNQCSGHLTVKEPPY--FVEKPQSQDVNPNTRVQLKALVGGTAPMTI 4799

Query: 165  TWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT 220
             WFKD        K   + +  S   + T+  L      A+D+G Y C+  N  GT
Sbjct: 4800 KWFKDN-------KELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGT 4848



 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 44/176 (25%), Positives = 66/176 (37%), Gaps = 22/176 (12%)

Query: 46   VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITAS--YEDRVTFLPTGITFKSVTRED 103
            V + C   G     V W F +G         N+I++   Y+  +T     +T   +   D
Sbjct: 7699 VVMECKVYGSPPISVSW-FHEG---------NEISSGRKYQTTLTDNTCALTVNMLEESD 7748

Query: 104  TGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
            +G YTC+ +   G+   E    L V  PPS      P     G     T S   G+PP  
Sbjct: 7749 SGDYTCIATNMAGSD--ECSAPLTVREPPSFVQKPDPMDVLTGTNVTFT-SIVKGTPPFS 7805

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
             +WFK    +    +   +  +S         EL    +  S +GEY+C   N  G
Sbjct: 7806 VSWFKGSSELVPGDRCNVSLEDS-------VAELELFDVDTSQSGEYTCIVSNEAG 7854



 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 41/180 (22%), Positives = 70/180 (38%), Gaps = 18/180 (10%)

Query: 50   CAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTC 109
            C  +G    +V W  D    +R +    K   SY +    L    T   V + D+G YTC
Sbjct: 8174 CHVTGTQPIKVSWAKD----SREIRSGGKYQISYLENSAHL----TVLKVDKGDSGQYTC 8225

Query: 110  MVSEEGGNSY--GEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWF 167
                E G      ++ +K  ++ P     ++     T GN   L      GS P    W+
Sbjct: 8226 YAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLE-GRVAGSQPITVAWY 8284

Query: 168  KDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAV 227
            K+ I +         F N++ VL      +       +D G Y+C+  N  G+ + ++++
Sbjct: 8285 KNNIEIQPTSNCEITFKNNTLVLQVRKAGM-------NDAGLYTCKVSNDAGSALCTSSI 8337



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 59/251 (23%), Positives = 91/251 (36%), Gaps = 68/251 (27%)

Query: 30   TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTF 89
            T+ S    V + E   V L C  SG+ SP V W  +          + +I +S + ++TF
Sbjct: 944  TLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYRE----------DYQIESSIDFQITF 993

Query: 90   LPTGIT---FKSVTREDTGTYTCMVSEEGG----NSYGEVKV------------------ 124
              +GI     +    ED+G +TC    E G    + Y  V+V                  
Sbjct: 994  -QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTE 1052

Query: 125  -------KLIVLVP---------PSKP------TVNIPSSATIGNRAVLTCSEQDGSPPS 162
                   + +V+           P +P      T  +      G   V  C +  G+P  
Sbjct: 1053 EKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGC-QVGGNPKP 1111

Query: 163  EYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGE--LVFDPLSASDTGEYSCEARNGYGT 220
               W K G+ + T  +   ++       N  TGE  LV     A D GEY+   RN +G 
Sbjct: 1112 HVYWKKSGVPLTTGYRYKVSY-------NKQTGECKLVISMTFADDAGEYTIVVRNKHGE 1164

Query: 221  PMTSNAVRMEA 231
               S ++  EA
Sbjct: 1165 TSASASLLEEA 1175



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 35/128 (27%), Positives = 56/128 (43%), Gaps = 10/128 (7%)

Query: 94    ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI--GNRAVL 151
             +T K  +  D G  TC+   + G    +  + L   +  +   ++ P S  I  G   + 
Sbjct: 33094 LTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLF 33153

Query: 152   TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
             TC E  G P  E  WFK+   +P +  S  + S S  V +     L     S SD+G+Y+
Sbjct: 33154 TC-EISGEPSPEIEWFKNN--LPISISSNVSISRSRNVYS-----LEIRNASVSDSGKYT 33205

Query: 212   CEARNGYG 219
              +A+N  G
Sbjct: 33206 IKAKNFRG 33213



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 45/177 (25%), Positives = 70/177 (39%), Gaps = 22/177 (12%)

Query: 46   VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
            V L  A  G     V W   Q     ++  + KI  S+ + V  L        V     G
Sbjct: 3941 VTLQAAVRGSEPISVTWMKGQ----EVIREDGKIKMSFSNGVAVL----IIPDVQISFGG 3992

Query: 106  TYTCMVSEEGGN--SYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
             YTC+   E G+  S GE+ VK    +      + +    T G+ A L  +   G+P  +
Sbjct: 3993 KYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQV----TAGDPATLEYTVA-GTPELK 4047

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT 220
              W+KDG  +  + K   +F N+         +L F      D+G+Y+ E  N  G+
Sbjct: 4048 PKWYKDGRPLVASKKYRISFKNN-------VAQLKFYSAELHDSGQYTFEISNEVGS 4097



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 50/206 (24%), Positives = 74/206 (35%), Gaps = 42/206 (20%)

Query: 42    ENNPVKLSCAYSGFS-SPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVT 100
             E   VK  C    +  S +V W F      R +  + K   +YED V  L      K +T
Sbjct: 31581 EGGHVKYVCKIENYDQSTQVTWYFG----VRQLENSEKYEITYEDGVAILYV----KDIT 31632

Query: 101   REDTGTYTCMVSEEGG--NSYGEVKVK-----------------------LIVLVPPSKP 135
             + D GTY C V  + G  +SY E+ VK                       + +L  P + 
Sbjct: 31633 KLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEF 31692

Query: 136   TVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTG 195
             T+ + +        V         P    TW+K G       K     ++  Y      G
Sbjct: 31693 TLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSG------QKIKPGDNDKKYTFESDKG 31746

Query: 196   --ELVFDPLSASDTGEYSCEARNGYG 219
               +L  + ++  D  EY+  ARN YG
Sbjct: 31747 LYQLTINSVTTDDDAEYTVVARNKYG 31772



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 41/191 (21%), Positives = 75/191 (39%), Gaps = 23/191 (12%)

Query: 43   NNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRE 102
            N  V+L     G +   ++W  D  +      ++    + ++D  +   T +   +    
Sbjct: 4782 NTRVQLKALVGGTAPMTIKWFKDNKEL-----HSGAARSVWKDDTS---TSLELFAAKAT 4833

Query: 103  DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI---GNRAVLTCSEQDGS 159
            D+GTY C +S + G +    K  L V  PP    +  PS   +   G      C +  G+
Sbjct: 4834 DSGTYICQLSNDVGTATS--KATLFVKEPPQ--FIKKPSPVLVLRNGQSTTFEC-QITGT 4888

Query: 160  PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            P    +W+ DG  +    K   +F +       +   +        ++G Y CEARN  G
Sbjct: 4889 PKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARV-------ENSGTYVCEARNDAG 4941

Query: 220  TPMTSNAVRME 230
            T   S  ++++
Sbjct: 4942 TASCSIELKVK 4952



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 37/139 (26%), Positives = 57/139 (41%), Gaps = 13/139 (9%)

Query: 96   FKSVTRE-DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCS 154
            F S TR+ D G YT +     G +   V + +    PP       P +   G  A   C+
Sbjct: 3206 FISETRQSDAGEYTFVA----GRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARF-CA 3260

Query: 155  EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
               G P  + +W+K+  ++ T  K         Y L      L+ +     D   Y+CEA
Sbjct: 3261 VISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL------LLIEAFP-EDAAVYTCEA 3313

Query: 215  RNGYGTPMTSNAVRMEAVE 233
            +N YG   TS ++ +E  E
Sbjct: 3314 KNDYGVATTSASLSVEVPE 3332



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 27/116 (23%), Positives = 48/116 (41%), Gaps = 10/116 (8%)

Query: 104  TGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
            +G YTC+VS   G +    +   + +  P+     +   +    ++++  S   G+ P  
Sbjct: 5960 SGEYTCVVSNNAGQASCTTR---LFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPIS 6016

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
             TW KDG  + T+ K     +  + +L            +  D G+YSCE  N  G
Sbjct: 6017 VTWKKDGFNITTSEKCNIVTTEKTCILEILNS-------TKRDAGQYSCEIENEAG 6065



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 32/117 (27%), Positives = 46/117 (39%), Gaps = 10/117 (8%)

Query: 103  DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPS 162
            D G Y C V+ E G+S    +V L    PPS       +S+  G  A    + + GS P 
Sbjct: 4459 DAGEYQCRVTNEVGSSICSARVTL--REPPSFIKKIESTSSLRGGTAAFQATLK-GSLPI 4515

Query: 163  EYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              TW KD   +  +      F N+          L    +     G+Y C+A+N  G
Sbjct: 4516 TVTWLKDSDEITEDDNIRMTFENN-------VASLYLSGIEVKHDGKYVCQAKNDAG 4565



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 32/143 (22%), Positives = 56/143 (39%), Gaps = 14/143 (9%)

Query: 77   NKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPT 136
            ++   S ED V  L        V    +G YTC+VS E G +        + +  P+K  
Sbjct: 7819 DRCNVSLEDSVAELE----LFDVDTSQSGEYTCIVSNEAGKASCTTH---LYIKAPAKFV 7871

Query: 137  VNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGE 196
              +   +    + ++      G+PP   TW K+GI +  + +     +  S +L   +  
Sbjct: 7872 KRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSS- 7930

Query: 197  LVFDPLSASDTGEYSCEARNGYG 219
                  +  D G+Y+C   N  G
Sbjct: 7931 ------TVEDAGQYNCYIENASG 7947



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 34/123 (27%), Positives = 49/123 (39%), Gaps = 10/123 (8%)

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQD 157
            S    D G Y C+V+ E G   G +   L  L  P      +     +G + V   +   
Sbjct: 3892 SFNSADVGEYECVVANEVGKC-GCMATHL--LKEPPTFVKKVDDLIALGGQTVTLQAAVR 3948

Query: 158  GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
            GS P   TW K   V+  + K   +FSN   V       L+   +  S  G+Y+C A N 
Sbjct: 3949 GSEPISVTWMKGQEVIREDGKIKMSFSNGVAV-------LIIPDVQISFGGKYTCLAENE 4001

Query: 218  YGT 220
             G+
Sbjct: 4002 AGS 4004



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 33/134 (24%), Positives = 51/134 (38%), Gaps = 10/134 (7%)

Query: 94   ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTC 153
            +   ++T +D G Y+C  S + G      + +LI++  P       P  + I  +  L C
Sbjct: 3608 LELSNLTIQDRGVYSCKASNKFGADI--CQAELIIIDKPHFIKELEPVQSAINKKVHLEC 3665

Query: 154  SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCE 213
             + D       TW KDG  +P        F +    L     +L        D+G Y C 
Sbjct: 3666 -QVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKL-------KDSGTYVCT 3717

Query: 214  ARNGYGTPMTSNAV 227
            A N  G+   S  V
Sbjct: 3718 ASNEAGSSSCSATV 3731



 Score = 37.7 bits (86), Expect = 0.012
 Identities = 49/198 (24%), Positives = 72/198 (36%), Gaps = 38/198 (19%)

Query: 42   ENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVT-FLPT-GITFKSV 99
            E  P +  C  SG +  +V W             + KI  S   R+T F  T  +     
Sbjct: 3358 EGQPARFQCRVSG-TDLKVSW----------YSKDKKIKPSRFFRMTQFEDTYQLEIAEA 3406

Query: 100  TREDTGTYTCMVSEEGGNSYGEVKVKL--------------IVLVPPSKPTVNI---PSS 142
              ED GTYT + S   G       + L              I +   + P +     P  
Sbjct: 3407 YPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLE 3466

Query: 143  ATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPL 202
              +G+ A  TC  Q  +P   + WFK G  +  + K +    +S Y+       L     
Sbjct: 3467 VALGHLAKFTCEIQS-APNVRFQWFKAGREIYESDKCS--IRSSKYI-----SSLEILRT 3518

Query: 203  SASDTGEYSCEARNGYGT 220
               D GEY+C+A N YG+
Sbjct: 3519 QVVDCGEYTCKASNEYGS 3536



 Score = 37.7 bits (86), Expect = 0.012
 Identities = 42/173 (24%), Positives = 59/173 (34%), Gaps = 17/173 (9%)

Query: 45   PVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDT 104
            PV   C  +G    +V W  D      L+  +  +  S+   V  L    T +S      
Sbjct: 7132 PVAFECRINGSEPLQVSWYKDGV----LLKDDANLQTSFVHNVATLQILQTDQS----HI 7183

Query: 105  GTYTCMVSEEGGNSYGEVKVKLIVL-VPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
            G Y C  S   G +    K+ L    VPP      +     +G      C    G+ P +
Sbjct: 7184 GQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKC-HVTGTAPIK 7242

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
             TW KD        +  R   N    L   T  L    +   D G+Y+C A N
Sbjct: 7243 ITWAKDN-------REIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASN 7288



 Score = 37.0 bits (84), Expect = 0.021
 Identities = 23/79 (29%), Positives = 36/79 (45%), Gaps = 6/79 (7%)

Query: 158  GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
            G P  E  WF DG       +    +++   +    T  L+  P + SD+GE++  A+N 
Sbjct: 1482 GRPMPETFWFHDG------QQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNR 1535

Query: 218  YGTPMTSNAVRMEAVERNV 236
             G    S  + +EAVE  V
Sbjct: 1536 AGRSSISVILTVEAVEHQV 1554



 Score = 37.0 bits (84), Expect = 0.021
 Identities = 47/216 (21%), Positives = 77/216 (35%), Gaps = 19/216 (8%)

Query: 33   SSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPT 92
            S  P V   +N  V L C  SG     V W  D+           + +  Y+       T
Sbjct: 5521 SFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQL--------RSSKKYKIASKNFHT 5572

Query: 93   GITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLT 152
             I   +V   D G Y C    E G+   +  V  + L  P +    + S   +       
Sbjct: 5573 SIHILNVDTSDIGEYHCKAQNEVGS---DTCVCTVKLKEPPRFVSKLNSLTVVAGEPAEL 5629

Query: 153  CSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSC 212
             +  +G+ P    W K+   +    ++ R     ++V N  T  L F     ++ G+Y C
Sbjct: 5630 QASIEGAQPIFVQWLKEKEEVIRESENIRI----TFVENVAT--LQFAKAEPANAGKYIC 5683

Query: 213  EARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLI 248
            + +N  G  M  N   +  +E  V V  A  +   +
Sbjct: 5684 QIKNDGG--MRENMATLMVLEPAVIVEKAGPMTVTV 5717



 Score = 36.6 bits (83), Expect = 0.028
 Identities = 33/103 (32%), Positives = 45/103 (43%), Gaps = 8/103 (7%)

Query: 123   KVKLIVLVPPSKPTVNIPSSATIGNRAVLTCS-EQDGSPPSEYTWFKDGIVMPTNPKSTR 181
             KV+ + +  P K T  + + A+    A LTC  E       E TW+KDG  +  N     
Sbjct: 32708 KVQHLPVSAPPKITQFLKAEAS-KEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQF 32766

Query: 182   AFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTS 224
              +S         T EL  + L+ SD GEY CE     GT  T+
Sbjct: 32767 HYSADG------TYELKINNLTESDQGEYVCEISGEGGTSKTN 32803



 Score = 36.2 bits (82), Expect = 0.036
 Identities = 28/99 (28%), Positives = 41/99 (41%), Gaps = 10/99 (10%)

Query: 38    VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
             + +P   PV+L    +G   P   W F  G   R    + ++T     +V  L    T +
Sbjct: 29748 IHVPAGRPVELVIPIAGRPPPAASWFF-AGSKLR---ESERVTVETHTKVAKL----TIR 29799

Query: 98    SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPT 136
               T  DTG YT  +    G +   +KV  I+L  P  PT
Sbjct: 29800 ETTIRDTGEYTLELKNVTGTTSETIKV--IILDKPGPPT 29836



 Score = 35.8 bits (81), Expect = 0.047
 Identities = 27/101 (26%), Positives = 41/101 (40%), Gaps = 16/101 (15%)

Query: 37    EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG--I 94
             E  I   + ++LS    G   P+V WK +  D            A  + R+   P G  +
Sbjct: 17227 EQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRD------------APTKARIDVTPVGSKL 17274

Query: 95    TFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKP 135
               ++   ED G Y+  V    G+    V VK++VL  P  P
Sbjct: 17275 EIRNAAHEDGGIYSLTVENPAGSK--TVSVKVLVLDKPGPP 17313



 Score = 35.0 bits (79), Expect = 0.080
 Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 30/128 (23%)

Query: 122   VKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTR 181
             +++  + L    K TV I + A++  R +++ S   G PP   TW K GI +     ++R
Sbjct: 29441 IEIPDLELADDLKKTVTIRAGASL--RLMVSVS---GRPPPVITWSKQGIDL-----ASR 29490

Query: 182   AF--SNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG------------YGTPMTSNAV 227
             A   +  SY L      L+ D ++  D G+Y+ EA N             Y TP    +V
Sbjct: 29491 AIIDTTESYSL------LIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSV 29544

Query: 228   RMEAVERN 235
             +++ V R+
Sbjct: 29545 KVKEVSRD 29552



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 29/100 (29%), Positives = 39/100 (39%), Gaps = 11/100 (11%)

Query: 121   EVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKST 180
             E +   IVL P  K  + I +  TI    VL      G P  + +W K G       K  
Sbjct: 20372 EYEAPTIVLDPTIKDGLTIKAGDTI----VLNAISILGKPLPKSSWSKAG-------KDI 20420

Query: 181   RAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT 220
             R    +     PT+  L     +  D GEY+  A N +GT
Sbjct: 20421 RPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGT 20460



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 26/84 (30%), Positives = 37/84 (44%), Gaps = 8/84 (9%)

Query: 86    RVTFLPTG--ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSA 143
             ++T  PT   +T K  TR+D G YT   +   G     VKV ++ +  P  P   +  S 
Sbjct: 20427 QITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGP---VEISN 20483

Query: 144   TIGNRAVLTCS---EQDGSPPSEY 164
                 +A LT +   E  GSP   Y
Sbjct: 20484 VSAEKATLTWTPPLEDGGSPIKSY 20507



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 32/143 (22%), Positives = 50/143 (34%), Gaps = 12/143 (8%)

Query: 94    ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGN------ 147
             +T  SVT +D   YT +   + G    + K+ + +  PP+  T+       + N      
Sbjct: 31750 LTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEG 31809

Query: 148   RAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDT 207
             ++V       G PP    W KDG  +   P          Y        L        DT
Sbjct: 31810 QSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYY------ALHIRDTLPEDT 31863

Query: 208   GEYSCEARNGYGTPMTSNAVRME 230
             G Y   A N  G+      +++E
Sbjct: 31864 GYYRVTATNTAGSTSCQAHLQVE 31886



 Score = 34.3 bits (77), Expect = 0.14
 Identities = 28/106 (26%), Positives = 41/106 (38%), Gaps = 10/106 (9%)

Query: 47    KLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGT 106
             +L    SG   P +EW  D  +           TA  E ++    T +  K  TR D+G 
Sbjct: 21480 RLEADVSGRPPPTMEWSKDGKELEG--------TAKLEIKIADFSTNLVNKDSTRRDSGA 21531

Query: 107   YTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLT 152
             YT   +  GG +     VK  VL  P  P   +  +     + VL+
Sbjct: 21532 YTLTATNPGGFAKHIFNVK--VLDRPGPPEGPLAVTEVTSEKCVLS 21575



 Score = 33.9 bits (76), Expect = 0.18
 Identities = 29/117 (24%), Positives = 48/117 (41%), Gaps = 13/117 (11%)

Query: 94   ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTC 153
            +  + +T+ED G Y+  +   G ++ G V V  + ++ P K  VN+      G +AVL C
Sbjct: 2412 LLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLK-DVNVIE----GTKAVLEC 2466

Query: 154  SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEY 210
                    S   +  D  + P +            ++  T   LV +   ASD G Y
Sbjct: 2467 KVSVPDVTSVKWYLNDEQIKPDD--------RVQAIVKGTKQRLVINRTHASDEGPY 2515



 Score = 33.9 bits (76), Expect = 0.18
 Identities = 26/117 (22%), Positives = 48/117 (41%), Gaps = 10/117 (8%)

Query: 103  DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPS 162
            ++G Y+C+V+ + G++       L V  P +        S   G+  VL  +   G+PP 
Sbjct: 6900 ESGDYSCLVTNDAGSA--SCTTHLFVKEPATFVKRLADFSVETGSPIVLEAT-YTGTPPI 6956

Query: 163  EYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              +W KD  ++  + + +   +  S +L      +        D  +YSC   N  G
Sbjct: 6957 SVSWIKDEYLISQSERCSITMTEKSTILEILESTI-------EDYAQYSCLIENEAG 7006



 Score = 33.9 bits (76), Expect = 0.18
 Identities = 28/111 (25%), Positives = 45/111 (40%), Gaps = 23/111 (20%)

Query: 35    EPEVRIP-------ENNPVKLSCAYSGFSSPRVEWKFDQG---DTTRLVCYNNKITASYE 84
             +P V +P           +K+   + G     V W+ D     +TTR+   ++K      
Sbjct: 25394 KPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTV---- 25449

Query: 85    DRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKP 135
                    T ++ K  ++ED GTY   VS   G+    V + +IVL  P  P
Sbjct: 25450 -------TSLSIKEASKEDVGTYELCVSNSAGSI--TVPITIIVLDRPGPP 25491



 Score = 33.5 bits (75), Expect = 0.23
 Identities = 25/102 (24%), Positives = 42/102 (41%), Gaps = 12/102 (11%)

Query: 38    VRIPENNPVKLSCAYSGFSSPRVEWKFDQG----DTTRLVCYNNKITASYEDRVTFLPTG 93
             +++    PV +    +G   P++EW  ++      T  L     +++ S       +P  
Sbjct: 15408 IKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKA 15467

Query: 94    ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKP 135
             +      RED GTYT   S   G+ +  V V+  V   PS P
Sbjct: 15468 V------REDKGTYTVTASNRLGSVFRNVHVE--VYDRPSPP 15501



 Score = 33.1 bits (74), Expect = 0.31
 Identities = 21/76 (27%), Positives = 39/76 (51%), Gaps = 9/76 (11%)

Query: 158 GSPPSEYTWFKDGIVMPTN--PKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
           G P  E +WF+DG V+ T+  P    +FS+          +L    ++ +++G YS +A 
Sbjct: 31  GFPVPEVSWFRDGQVISTSTLPGVQISFSDG-------RAKLTIPAVTKANSGRYSLKAT 83

Query: 216 NGYGTPMTSNAVRMEA 231
           NG G   ++  + ++A
Sbjct: 84  NGSGQATSTAELLVKA 99



 Score = 32.7 bits (73), Expect = 0.40
 Identities = 41/193 (21%), Positives = 71/193 (36%), Gaps = 24/193 (12%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
            V + E   V+LSC   G    R++W        R +  +++ + S+      L      +
Sbjct: 8355 VTVSEGEYVQLSCHVQGSEPIRIQWL----KAGREIKPSDRCSFSFASGTAVL----ELR 8406

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKL---IVLVPPSKPT--------VNIPSSATIG 146
             V + D+G Y C  S   G+   + KV +     + P +K          V+ P S  + 
Sbjct: 8407 DVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVV 8466

Query: 147  NRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASD 206
             +   T   + G  P     +  G     N +  R F +          +L     + +D
Sbjct: 8467 EKTTATFIAKVGGDPIPNVKWTKGKWRQLN-QGGRVFIHQ----KGDEAKLEIRDTTKTD 8521

Query: 207  TGEYSCEARNGYG 219
            +G Y C A N +G
Sbjct: 8522 SGLYRCVAFNEHG 8534



 Score = 32.7 bits (73), Expect = 0.40
 Identities = 22/94 (23%), Positives = 39/94 (41%), Gaps = 14/94 (14%)

Query: 37    EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRV----TFLPT 92
             ++ I E   + ++CA++G  +P V W           C   KI +  + R     T   T
Sbjct: 33337 DISIDEGKVLTVACAFTGEPTPEVTWS----------CGGRKIHSQEQGRFHIENTDDLT 33386

Query: 93    GITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKL 126
              +    V ++D G YT  +  E G+    V + +
Sbjct: 33387 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420



 Score = 32.3 bits (72), Expect = 0.52
 Identities = 27/101 (26%), Positives = 37/101 (36%), Gaps = 13/101 (12%)

Query: 39   RIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG---IT 95
            RI E   V   C  SG+  P++ W  D            +I      ++ FL  G   + 
Sbjct: 1301 RILEGMGVTFHCKMSGYPLPKIAWYKD----------GKRIKHGERYQMDFLQDGRASLR 1350

Query: 96   FKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPT 136
               V  ED G YT   S   GN+    K+ +    P   PT
Sbjct: 1351 IPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPT 1391



 Score = 32.3 bits (72), Expect = 0.52
 Identities = 48/216 (22%), Positives = 80/216 (37%), Gaps = 32/216 (14%)

Query: 41    PENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGI---TFK 97
             P + P+KL       ++  + WK  + D        + +T    + + + PTG     ++
Sbjct: 16011 PPDPPIKLKIGLITKNTVHLSWKPPKNDG------GSPVTHYIVECLAWDPTGTKKEAWR 16064

Query: 98    SVTREDTGTYTCMVSE--EGGNSYGEVKVKLIVLVPPSKPTVNI----------PSSATI 145
                + D       V +  EGG    E +VK +     SKP+  +          P S  +
Sbjct: 16065 QCNKRDVEELQFTVEDLVEGGEY--EFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDL 16122

Query: 146   GN-------RAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELV 198
                        V   ++  G P    TWFK     P N +     ++ + ++   T  LV
Sbjct: 16123 KEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLV 16182

Query: 199   FDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVER 234
                   SDTG Y+  A N  GT   S  +R+  + R
Sbjct: 16183 IPQSRRSDTGLYTITAVNNLGT--ASKEMRLNVLGR 16216



 Score = 32.0 bits (71), Expect = 0.68
 Identities = 34/112 (30%), Positives = 48/112 (42%), Gaps = 16/112 (14%)

Query: 27    GSVTVHS------SEPE-VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKI 79
             G V VH       S+P+ + I E    +  C+ S  S P V+WK D  D T        +
Sbjct: 12543 GKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFP-VQWKRD--DKTLESGDKYDV 12599

Query: 80    TASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVP 131
              A  + RV      +  K  T +D GTY  MV      ++  V  KL ++VP
Sbjct: 12600 IADGKKRV------LVVKDATLQDMGTYVVMVGAARAAAHLTVIEKLRIVVP 12645



 Score = 31.6 bits (70), Expect = 0.89
 Identities = 30/122 (24%), Positives = 48/122 (39%), Gaps = 10/122 (8%)

Query: 44    NPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRED 103
             +P  +    SG  +P+V WK ++    RL   +     + +DR T     +T K   R D
Sbjct: 28663 SPFTIDVPISGRPAPKVTWKLEE---MRLKETDRVSITTTKDRTT-----LTVKDSMRGD 28714

Query: 104   TGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
             +G Y   +    G       V ++V+  P   T  I  S+      VL+  E      +E
Sbjct: 28715 SGRYFLTLENTAG--VKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTE 28772

Query: 164   YT 165
              T
Sbjct: 28773 IT 28774



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 33/137 (24%), Positives = 55/137 (40%), Gaps = 19/137 (13%)

Query: 30    TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGD---TTRLVCYNNKITASYEDR 86
             T+     ++ + E   + +   +     P V W  D  +   + RL   N+ I+A  E  
Sbjct: 14388 TIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLE-- 14445

Query: 87    VTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIG 146
                +P  +      R D G YT  +  + G++   + VK+I L  P K   +I +S    
Sbjct: 14446 ---VPKSV------RADAGIYTITLENKLGSATASINVKVIGLPGPCK---DIKASDITK 14493

Query: 147   NRAVLTCS--EQDGSPP 161
             +   LT    E DG  P
Sbjct: 14494 SSCKLTWEPPEFDGGTP 14510



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 22/92 (23%), Positives = 37/92 (40%), Gaps = 12/92 (13%)

Query: 38    VRIPENNPVKLSCAYSGFSSPRVEWKFDQGD--TTRLVCYNNKITASYEDRVTFLPTGIT 95
             V+      VKL    SG  +P +EW  D  +  T  LVC  N    +           I 
Sbjct: 26882 VKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLA----------SIL 26931

Query: 96    FKSVTREDTGTYTCMVSEEGGNSYGEVKVKLI 127
              K   R ++G Y   +    G++   ++V+++
Sbjct: 26932 IKDADRLNSGCYELKLRNAMGSASATIRVQIL 26963



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 7/67 (10%)

Query: 158   GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
             G PP   TW KD   + ++ + +   ++SS +L           ++ +DTG+Y     NG
Sbjct: 27297 GRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLT-------IPQVTRNDTGKYILTIENG 27349

Query: 218   YGTPMTS 224
              G P +S
Sbjct: 27350 VGEPKSS 27356



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 30/110 (27%), Positives = 43/110 (39%), Gaps = 22/110 (20%)

Query: 31    VHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFD-----QGDTTRLVCYNNKITASYED 85
             +  ++  VRI  N  V L   Y G   P + W  D     + +  R     NKIT S   
Sbjct: 27568 IPGAQVTVRIGHN--VHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLS--- 27622

Query: 86    RVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKP 135
                        K+  +E  G YT ++  +       V + +I L PPSKP
Sbjct: 27623 ----------IKNAKKEHGGKYTVIL--DNAVCRIAVPITVITLGPPSKP 27660



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 25/91 (27%), Positives = 32/91 (35%), Gaps = 10/91 (10%)

Query: 46    VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
             V+      G   P  +W  D  +         K    Y        + +T K+  R DTG
Sbjct: 17528 VRFPAIIRGVPVPTAKWTTDGSEI--------KTDEHYTVETDNFSSVLTIKNCLRRDTG 17579

Query: 106   TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPT 136
              Y   VS   G+    V V L VL  P  PT
Sbjct: 17580 EYQITVSNAAGSK--TVAVHLTVLDVPGPPT 17608



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 10/82 (12%)

Query: 140   PSSATI--GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGEL 197
             P S T+  G  A  +C + DG P    TW + G V+ T+ +     + + Y    +T E+
Sbjct: 32567 PRSMTVYEGESARFSC-DTDGEPVPTVTWLRKGQVLSTSAR--HQVTTTKY---KSTFEI 32620

Query: 198   VFDPLSASDTGEYSCEARNGYG 219
                 + ASD G YS    N  G
Sbjct: 32621 --SSVQASDEGNYSVVVENSEG 32640



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 20/79 (25%), Positives = 34/79 (43%), Gaps = 9/79 (11%)

Query: 139   IPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELV 198
             +  S  +G+ A+  C     +  +  TW KDG  +  +PK         ++ +    +L 
Sbjct: 11126 LTESEFVGSSAIFECLVSPSTAIT--TWMKDGSNIRESPKHR-------FIADGKDRKLH 11176

Query: 199   FDPLSASDTGEYSCEARNG 217
                +  SD GEY+C  R G
Sbjct: 11177 IIDVQLSDAGEYTCVLRLG 11195



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 24/110 (21%), Positives = 45/110 (40%), Gaps = 14/110 (12%)

Query: 36    PEVRIPENNPVK------LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTF 89
             P++ +PE   +K      +     G   P  +WK  + +    V  ++ +     D  + 
Sbjct: 18900 PKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDE----VVTSSHLAVHKADSSSI 18955

Query: 90    LPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNI 139
             L      K VTR+D+G Y+       G    ++KV ++    P +P  +I
Sbjct: 18956 L----IIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDI 19001



 Score = 29.3 bits (64), Expect = 4.4
 Identities = 23/91 (25%), Positives = 36/91 (39%), Gaps = 10/91 (10%)

Query: 46    VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
             +K+   + G  +P V W  D     +    N + T +         + +T K   RED G
Sbjct: 22165 LKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENN--------SLLTIKDACREDVG 22216

Query: 106   TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPT 136
              Y   ++   G +   + V  IVL  P  PT
Sbjct: 22217 HYVVKLTNSAGEAIETLNV--IVLDKPGPPT 22245



 Score = 29.3 bits (64), Expect = 4.4
 Identities = 24/98 (24%), Positives = 39/98 (39%), Gaps = 12/98 (12%)

Query: 38    VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
             + I     ++L     G  +P V+W    G+       +  +T+S+        T +   
Sbjct: 22952 INIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIID--VTSSF--------TSLVLD 23001

Query: 98    SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKP 135
             +V R D+G YT  +    G     V V+  VL  PS P
Sbjct: 23002 NVNRYDSGKYTLTLENSSGTKSAFVTVR--VLDTPSPP 23037



 Score = 29.3 bits (64), Expect = 4.4
 Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 12/90 (13%)

Query: 46    VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
             ++L     G   P V+W+  +G  T       ++T+S+        T +   +VTR D+G
Sbjct: 25125 LRLFVTIKGRPEPEVKWEKAEGILTDRA--QIEVTSSF--------TMLVIDNVTRFDSG 25174

Query: 106   TYTCMVSEEGGNSYGEVKVKLIVLVPPSKP 135
              Y   +    G+    V V+  VL  PS P
Sbjct: 25175 RYNLTLENNSGSKTAFVNVR--VLDSPSAP 25202



 Score = 29.3 bits (64), Expect = 4.4
 Identities = 24/93 (25%), Positives = 38/93 (40%), Gaps = 14/93 (15%)

Query: 158   GSPPSEYTWFKDGIVMP--TNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
             G P    TWFKDG+ +    N + T    ++S  +   T +           G Y+ EA+
Sbjct: 27984 GRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRD---------HRGVYTVEAK 28034

Query: 216   NGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLI 248
             N  G+      V+   V+   G +V  +  T I
Sbjct: 28035 NASGSAKAEIKVK---VQDTPGKVVGPIRFTNI 28064



 Score = 29.3 bits (64), Expect = 4.4
 Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 8/87 (9%)

Query: 145   IGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSA 204
             +G  A L+C +  G P  +  W++ G  +  + K   +    ++ L   T E        
Sbjct: 30546 LGEAAQLSC-QIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEE-------Q 30597

Query: 205   SDTGEYSCEARNGYGTPMTSNAVRMEA 231
              D G Y+C A N  G   TS+ + ++A
Sbjct: 30598 EDEGVYTCIATNEVGEVETSSKLLLQA 30624



 Score = 28.9 bits (63), Expect = 5.8
 Identities = 24/113 (21%), Positives = 45/113 (39%), Gaps = 9/113 (7%)

Query: 123  KVKLIVLVPPSKPTV--NIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKST 180
            +V   V +P + PT+   + +   I   +V       G P    TW+++   + ++    
Sbjct: 931  RVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ 990

Query: 181  RAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVE 233
              F +           L+     A D+G ++C A N  GT  TS  + ++  E
Sbjct: 991  ITFQSG-------IARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSE 1036



 Score = 28.9 bits (63), Expect = 5.8
 Identities = 26/113 (23%), Positives = 40/113 (35%), Gaps = 17/113 (15%)

Query: 20    LLCSLALGSVTVHSS-EPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNK 78
             + C   L   T+H     ++ I       L+  YSG   P+V W  D+ D          
Sbjct: 16809 ITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLE------- 16861

Query: 79    ITASYEDRVTFLPTGITFK----SVTREDTGTYTCMVSEEGGNSYGEVKVKLI 127
                  +DR     T  T         R D+G Y  +V    G+  G  +V ++
Sbjct: 16862 -----DDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVV 16909



 Score = 28.9 bits (63), Expect = 5.8
 Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 6/70 (8%)

Query: 98    SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCS--- 154
             SV R+D+G YT       G+    +K+K  VL  P  P  ++  +    +RA+L+     
Sbjct: 19357 SVNRKDSGDYTITAENSSGSKSATIKLK--VLDKPG-PPASVKINKMYSDRAMLSWEPPL 19413

Query: 155   EQDGSPPSEY 164
             E  GS  + Y
Sbjct: 19414 EDGGSEITNY 19423



 Score = 28.9 bits (63), Expect = 5.8
 Identities = 21/87 (24%), Positives = 35/87 (40%), Gaps = 8/87 (9%)

Query: 40    IPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSV 99
             I     +++     G   PRV W  D  +  + +  N +IT           T +  +  
Sbjct: 27970 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRM--NMEITDVLGS------TSLFVRDA 28021

Query: 100   TREDTGTYTCMVSEEGGNSYGEVKVKL 126
             TR+  G YT       G++  E+KVK+
Sbjct: 28022 TRDHRGVYTVEAKNASGSAKAEIKVKV 28048



 Score = 28.9 bits (63), Expect = 5.8
 Identities = 28/124 (22%), Positives = 45/124 (36%), Gaps = 18/124 (14%)

Query: 20    LLCSLALGSVTVHSSEPEVR-IPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNK 78
             L  S  L       S+P  + I E   V  +C  SG  SP +EW            + N 
Sbjct: 33124 LTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEW------------FKNN 33171

Query: 79    ITASYEDRVTFLPT----GITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLV-PPS 133
             +  S    V+   +     +  ++ +  D+G YT       G       + ++ LV  PS
Sbjct: 33172 LPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPS 33231

Query: 134   KPTV 137
             +  V
Sbjct: 33232 REVV 33235



 Score = 28.5 bits (62), Expect = 7.5
 Identities = 23/90 (25%), Positives = 35/90 (38%), Gaps = 8/90 (8%)

Query: 38    VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
             V I   + + L  A  G   P++ W   +GD    +C   K++  Y  +          K
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWT--KGDKELDLC--EKVSLQYTGK----RATAVIK 29108

Query: 98    SVTREDTGTYTCMVSEEGGNSYGEVKVKLI 127
                R D+G YT  V    G     V VK++
Sbjct: 29109 FCDRSDSGKYTLTVKNASGTKAVSVMVKVL 29138



 Score = 28.1 bits (61), Expect = 9.8
 Identities = 34/179 (18%), Positives = 68/179 (37%), Gaps = 31/179 (17%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPT---- 92
            ++ +PE+   +L C  S      +E K+          Y+N +      + T        
Sbjct: 2275 DIEVPESYSGELECIVS---PENIEGKW----------YHNDVELKSNGKYTITSRRGRQ 2321

Query: 93   GITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLT 152
             +T K VT+ED G Y+ ++  +G  +  ++K+K     P     +   S   +    ++ 
Sbjct: 2322 NLTVKDVTKEDQGEYSFVI--DGKKTTCKLKMK-----PRPIAILQGLSDQKVCEGDIVQ 2374

Query: 153  CSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
               +      E  W KDG       +  +       V++  +  L+ + ++  D G YS
Sbjct: 2375 LEVKVSLESVEGVWMKDG-------QEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYS 2426



 Score = 28.1 bits (61), Expect = 9.8
 Identities = 48/219 (21%), Positives = 77/219 (35%), Gaps = 52/219 (23%)

Query: 46    VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
             ++L    +G   P++ W         ++  + +IT     +     + +T     R DTG
Sbjct: 13708 IELPATVTGKPEPKITWT----KADMILKQDKRITIENVPK----KSTVTIVDSKRSDTG 13759

Query: 106   TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCS---EQDGSPPS 162
             TY        G +   V+V   VL  P  P     +  T     +LT +   +  GS  +
Sbjct: 13760 TYIIEAVNVCGRATAVVEVN--VLDKPGPPAAFDITDVT-NESCLLTWNPPRDDGGSKIT 13816

Query: 163   EY----------TWFK-DGIVMPTNPKSTRAFSNSSYVL----------------NPTTG 195
              Y           W K    V  TN K+T+   N  Y+                 +P T 
Sbjct: 13817 NYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITA 13876

Query: 196   ELVFDP------LSASDTGEYS-----CEARNGYGTPMT 223
             +  FDP      L  SD  + +     CE  +  G+P+T
Sbjct: 13877 KYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPIT 13915



 Score = 28.1 bits (61), Expect = 9.8
 Identities = 19/77 (24%), Positives = 34/77 (44%), Gaps = 9/77 (11%)

Query: 158   GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
             G PP   +WF  G  +  + + T          +    +L     +  DTGEY+ E +N 
Sbjct: 29764 GRPPPAASWFFAGSKLRESERVT-------VETHTKVAKLTIRETTIRDTGEYTLELKNV 29816

Query: 218   YGTPMTSNAVRMEAVER 234
              GT  TS  +++  +++
Sbjct: 29817 TGT--TSETIKVIILDK 29831


>gi|13376115 adipocyte-specific adhesion molecule [Homo sapiens]
          Length = 373

 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 75/307 (24%), Positives = 125/307 (40%), Gaps = 50/307 (16%)

Query: 16  ILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPR-----VEWKF--DQGD 68
           +L +LL S  +G++  H+   E++      V L C +     P      +EW    ++G+
Sbjct: 4   LLLLLLVSYYVGTLGTHT---EIKRVAEEKVTLPCHHQ-LGLPEKDTLDIEWLLTDNEGN 59

Query: 69  TTRLVCYN-----NKITASYEDRVTFLPT------GITFKSVTREDTGTYTCMVSEEGGN 117
              ++ Y+     N +T   + RV F          +  + +   D G YTC V   G  
Sbjct: 60  QKVVITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDEGRYTCKVKNSGRY 119

Query: 118 SYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTW----FKDGIVM 173
            +  V +K  VLV PSKP   +    T G+   L C    G+ P  Y W     K+G   
Sbjct: 120 VWSHVILK--VLVRPSKPKCELEGELTEGSDLTLQCESSSGTEPIVYYWQRIREKEGEDE 177

Query: 174 PTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVE 233
              PKS   +++         G ++   L+ S +G Y C A N  G       V ++ V+
Sbjct: 178 RLPPKSRIDYNH--------PGRVLLQNLTMSYSGLYQCTAGNEAGKESCVVRVTVQYVQ 229

Query: 234 RNVGVIVAAVLVTLILLGILVFG--IWFAYSRGHFDR---------TKKGTSSKKVIYSQ 282
            ++G++  A  VT I+ G L+    +W    R   +R          ++   + K    +
Sbjct: 230 -SIGMVAGA--VTGIVAGALLIFLLVWLLIRRKDKERYEEEERPNEIREDAEAPKARLVK 286

Query: 283 PSARSEG 289
           PS+ S G
Sbjct: 287 PSSSSSG 293


>gi|148664205 endothelial cell adhesion molecule [Homo sapiens]
          Length = 390

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 58/217 (26%), Positives = 95/217 (43%), Gaps = 20/217 (9%)

Query: 58  PRVEWKFDQGDTT-RLVCYNNKITASYE--DRVTFLPT---GITFKSVTREDTGTYTCMV 111
           P V W F Q +   +++ Y N +T S      V  +P+    +  + +  +D+G Y+C V
Sbjct: 69  PFVMWFFKQKEKEDQVLSYINGVTTSKPGVSLVYSMPSRNLSLRLEGLQEKDSGPYSCSV 128

Query: 112 S--EEGGNSYGEV--KVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWF 167
           +  ++ G S G     ++L VLVPP+ P+  +     +G    L+C      P  +Y W 
Sbjct: 129 NVQDKQGKSRGHSIKTLELNVLVPPAPPSCRLQGVPHVGANVTLSCQSPRSKPAVQYQWD 188

Query: 168 KDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAV 227
           +        P     F+ +   L+   G L    LS+S  G Y C+A N  GT    N  
Sbjct: 189 RQ------LPSFQTFFAPA---LDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQ-CNVT 238

Query: 228 RMEAVERNVGVIVAAVLVTLILLGILVFGIWFAYSRG 264
              +      V+  AV+ TL+ LG+L   +   + RG
Sbjct: 239 LEVSTGPGAAVVAGAVVGTLVGLGLLAGLVLLYHRRG 275


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 54/225 (24%), Positives = 85/225 (37%), Gaps = 29/225 (12%)

Query: 37  EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
           ++ I      +L CA +G  +P++ W+ D G             A+ E R+  +P    F
Sbjct: 607 DITIRTTTMARLECAATGHPNPQIAWQKDGG---------TDFPAARERRMHVMPDDDVF 657

Query: 97  --KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCS 154
               V  +D G Y+C      G+        L VL  PS          ++G    L C 
Sbjct: 658 FITDVKIDDAGVYSCTAQNSAGSI--SANATLTVLETPSLVVPLEDRVVSVGETVALQC- 714

Query: 155 EQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEA 214
           +  G+PP   TWFK    +    +         + L P    LV   + A D G Y+CE 
Sbjct: 715 KATGNPPPRITWFKGDRPLSLTER---------HHLTPDNQLLVVQNVVAEDAGRYTCEM 765

Query: 215 RNGYGTPMTSN------AVRMEAVERNVGVIVAAVLVTLILLGIL 253
            N  GT    +      A         VG+   AV+ +++L  ++
Sbjct: 766 SNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLV 810



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 48/183 (26%), Positives = 72/183 (39%), Gaps = 11/183 (6%)

Query: 46  VKLSC-AYSGFSSPRV-EWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRED 103
           ++ +C A S  SSP    WK D    T     N     + +  V    T +  + VT   
Sbjct: 512 IRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGH 571

Query: 104 TGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
            G Y C+++   G++Y   K +L V V PS        +      A L C+   G P  +
Sbjct: 572 EGRYQCVITNHFGSTYSH-KARLTVNVLPSFTKTPHDITIRTTTMARLECA-ATGHPNPQ 629

Query: 164 YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMT 223
             W KDG           A     +V+ P         +   D G YSC A+N  G+ ++
Sbjct: 630 IAWQKDG-----GTDFPAARERRMHVM-PDDDVFFITDVKIDDAGVYSCTAQNSAGS-IS 682

Query: 224 SNA 226
           +NA
Sbjct: 683 ANA 685


>gi|13489095 sialoadhesin precursor [Homo sapiens]
          Length = 1709

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 65/258 (25%), Positives = 108/258 (41%), Gaps = 21/258 (8%)

Query: 34   SEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG 93
            +EP + +PE   + LSC   G   P        G++T    +N++   +       +PT 
Sbjct: 1449 AEPGLDVPEGAALNLSCRLLGGPGP-------VGNSTFAWFWNDRRLHAEP-----VPT- 1495

Query: 94   ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTC 153
            + F  V R   G Y C+     G +     V L VL PP  PT+ +      G R +L C
Sbjct: 1496 LAFTHVARAQAGMYHCLAELPTGAA-ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDC 1554

Query: 154  SEQDGSPPSEYTWFKDG-IVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSC 212
               D  P +  T      +V  + P+   A  +   + +P    +  + L  SD GEY C
Sbjct: 1555 -RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYIC 1613

Query: 213  EARNGYGTPMTSNAVRMEAVER----NVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDR 268
             A N  G+  TS    + A+ R       + V  +LV L+LL +L  G  + + R    +
Sbjct: 1614 SASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLL-LLGLGACYTWRRRRVCK 1672

Query: 269  TKKGTSSKKVIYSQPSAR 286
               G +S ++ + + + +
Sbjct: 1673 QSMGENSVEMAFQKETTQ 1690



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 49/203 (24%), Positives = 78/203 (38%), Gaps = 42/203 (20%)

Query: 59  RVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGI-----TFKSVTREDTGTYT-CMVS 112
           R++W+    D  R V +N++          F PTG+        +++ +D G    C +S
Sbjct: 172 RLQWQGQ--DPARSVTFNSQ---------KFEPTGVGHLETLHMAMSWQDHGRILRCQLS 220

Query: 113 EEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI--GNRAVLTCSEQDGSPP-SEYTWFKD 169
                +  E+ ++ +   P     +  PS   I  G    LTC      P  S   W KD
Sbjct: 221 VANHRAQSEIHLQ-VKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKD 279

Query: 170 GIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT----PMTSN 225
           G+ + T                  TG L     + SD G Y+C+A NG G+    P++ +
Sbjct: 280 GVRLQTK-----------------TGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322

Query: 226 AVRMEAVERNVGVIVAAVLVTLI 248
               E      G I+    VTL+
Sbjct: 323 IFMAEVQVSPAGPILENQTVTLV 345



 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 35/133 (26%), Positives = 53/133 (39%), Gaps = 5/133 (3%)

Query: 94  ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTC 153
           +T   V R D   Y C +  E G       V L VL PP +P ++       G+ A+  C
Sbjct: 759 VTLLPVARTDAALYACRILTEAGAQLS-TPVLLSVLYPPDRPKLSALLDMGQGHMALFIC 817

Query: 154 SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFD--PLSASDTGEYS 211
           +  D  P +    F    ++ T+    +  S+  +        L  +   L   D+G Y 
Sbjct: 818 TV-DSRPLALLALFHGEHLLATS-LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYR 875

Query: 212 CEARNGYGTPMTS 224
           CEA N  G+  TS
Sbjct: 876 CEATNVLGSSNTS 888



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 45/196 (22%), Positives = 74/196 (37%), Gaps = 20/196 (10%)

Query: 36   PEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGIT 95
            PE  +PE  P+ ++CA     +P           T    Y+N          +     ++
Sbjct: 1267 PEAAVPEGAPITVTCADPAAHAP-----------TLYTWYHNGRWLQEGPAAS-----LS 1310

Query: 96   FKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSE 155
            F   TR   G Y+C   +  G         L VL  P    ++    +   + AV+ C+ 
Sbjct: 1311 FLVATRAHAGAYSCQAQDAQGTRSSR-PAALQVLYAPQDAVLSSFRDSRARSMAVIQCT- 1368

Query: 156  QDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYV-LNPTTGELVFDPLSASDTGEYSCEA 214
             D  PP+E     DG V+ T+       S + +V +      L    + A D   Y C A
Sbjct: 1369 VDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTYVCTA 1427

Query: 215  RNGYGTPMTSNAVRME 230
            +N  G+  T   +++E
Sbjct: 1428 QNLLGSISTIGRLQVE 1443



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 35/135 (25%), Positives = 51/135 (37%), Gaps = 7/135 (5%)

Query: 100 TREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGS 159
           TR DTG Y C V    G+      V ++V  PP  P +        G   +L CS     
Sbjct: 381 TRADTGFYFCEVQNVHGSERSG-PVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVS-E 438

Query: 160 PPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           P +       G ++ +    +      S    P +  L    L  +D+GEY C A N  G
Sbjct: 439 PLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG 498

Query: 220 TPMT-----SNAVRM 229
              +     +NA R+
Sbjct: 499 NATSTLDFHANAARL 513



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 27/118 (22%), Positives = 49/118 (41%), Gaps = 20/118 (16%)

Query: 103  DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPS 162
            D G Y+C      G +   ++++L  +     P   +P  A I     +TC++     P+
Sbjct: 1235 DEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPI----TVTCADPAAHAPT 1290

Query: 163  EYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT 220
             YTW+ +G  +   P ++                L F   + +  G YSC+A++  GT
Sbjct: 1291 LYTWYHNGRWLQEGPAAS----------------LSFLVATRAHAGAYSCQAQDAQGT 1332



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 37/139 (26%), Positives = 53/139 (38%), Gaps = 11/139 (7%)

Query: 94   ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTC 153
            I   +VT  D  +Y C V   G        + L VL  P    +     +  G  A++ C
Sbjct: 1134 IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC 1193

Query: 154  SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCE 213
            +  D  PP++      G          R  ++S+    P T  L        D G YSC 
Sbjct: 1194 TV-DSRPPAQLALSHAG----------RLLASSTAASVPNTLRLELRGPQPRDEGFYSCS 1242

Query: 214  ARNGYGTPMTSNAVRMEAV 232
            AR+  G   TS  +R+E V
Sbjct: 1243 ARSPLGQANTSLELRLEGV 1261



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 26/126 (20%), Positives = 51/126 (40%), Gaps = 21/126 (16%)

Query: 94  ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTC 153
           +  + +   D+G Y C  +    NS G     L      ++  ++  +    G    L+C
Sbjct: 476 LEIRDLEETDSGEYKCSAT----NSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSC 531

Query: 154 -SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSC 212
            S    +P + ++W+ +G ++   P S+                L+    S++D G Y C
Sbjct: 532 RSGLSPTPDARFSWYLNGALLHEGPGSS----------------LLLPAASSTDAGSYHC 575

Query: 213 EARNGY 218
            AR+G+
Sbjct: 576 RARDGH 581



 Score = 37.0 bits (84), Expect = 0.021
 Identities = 36/145 (24%), Positives = 52/145 (35%), Gaps = 13/145 (8%)

Query: 92  TGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNI-----PSSATIG 146
           + +   + +  D G+Y C   +    S       L VL PP +PT         + A  G
Sbjct: 558 SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAG 617

Query: 147 NRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPK----STRAFSNSSYVLNPTTGEL---VF 199
            R +L C      P       KD +V  + P     ST    +    +      L   + 
Sbjct: 618 RRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIH 677

Query: 200 DPLSASDTGEYSCEARNGYGTPMTS 224
           +PL   + G Y CEA N  G   TS
Sbjct: 678 NPL-LEEEGLYLCEASNALGNASTS 701



 Score = 33.9 bits (76), Expect = 0.18
 Identities = 27/114 (23%), Positives = 43/114 (37%), Gaps = 21/114 (18%)

Query: 103 DTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPP- 161
           D+G+Y C    E  N  G     L   V  +   V+       G   VL+C    G P  
Sbjct: 870 DSGSYRC----EATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEG 925

Query: 162 SEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
           + Y W++DG  +  +  +T                L F  ++ +  G Y C+A+
Sbjct: 926 TSYRWYRDGQPLQESTSAT----------------LRFAAITLTQAGAYHCQAQ 963



 Score = 32.3 bits (72), Expect = 0.52
 Identities = 34/148 (22%), Positives = 49/148 (33%), Gaps = 6/148 (4%)

Query: 94   ITFKSVTREDTGTYTCMVSEEGGNSYG-EVKVKLIVLVPPSKPTVNIPSSATIGNRAVLT 152
            + F ++T    G Y C     G  +      + L V   P   T+        G   +L 
Sbjct: 945  LRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLL 1004

Query: 153  CSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLN----PTTGELVFDPLSASDTG 208
            C   D  PP++        ++ +  +       SS  L+    P T  L        D G
Sbjct: 1005 C-RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEG 1063

Query: 209  EYSCEARNGYGTPMTSNAVRMEAVERNV 236
             Y CEA N  G    S     +AV   V
Sbjct: 1064 VYICEASNTLGQASASADFDAQAVNVQV 1091


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 54/193 (27%), Positives = 79/193 (40%), Gaps = 34/193 (17%)

Query: 33  SSEPE-VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLP 91
           +SEP+   +   N V  +C   G   P + W  +          NN+++   + R+  L 
Sbjct: 249 TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRN----------NNELSMKTDSRLNLLD 298

Query: 92  TGITFKSVTRE-DTGTYTCMVSEEGGNSYGEVKVKLIVLV---PPSKPTVNIPSSAT--- 144
            G      T+E D G Y CM      N  GEVK + + L     P++PT  I    T   
Sbjct: 299 DGTLMIQNTQETDQGIYQCMAK----NVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVL 354

Query: 145 IGNRAVLTCSEQDGSPPSEYTWFK-DGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLS 203
           +G    L CS   G PP   +W + D   +P +P+     S   Y+ N   G        
Sbjct: 355 VGESVTLECSAT-GHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG-------- 405

Query: 204 ASDTGEYSCEARN 216
             D+GEY+C A N
Sbjct: 406 --DSGEYACSATN 416



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 59/213 (27%), Positives = 84/213 (39%), Gaps = 32/213 (15%)

Query: 42  ENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTR 101
           E   V   C   G   P + W   +G +   V   + + +S   R++          V  
Sbjct: 446 EGQTVDFQCEAKGNPPPVIAWT--KGGSQLSVDRRHLVLSSGTLRIS---------GVAL 494

Query: 102 EDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTV--NIPSSATI--GNRAVLTCSEQD 157
            D G Y C    +  N  G  KV   + V P    V  +IPS  T+  G    L CS Q 
Sbjct: 495 HDQGQYEC----QAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQ- 549

Query: 158 GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
           G P    TW KDG+ +  + K         + ++P  G L  + +  +D G Y C ARN 
Sbjct: 550 GEPEPAITWNKDGVQVTESGK---------FHISPE-GFLTINDVGPADAGRYECVARNT 599

Query: 218 YGTPMTSN--AVRMEAVERNVGVIVAAVLVTLI 248
            G+   S   +V +  V RN    VA  +V  I
Sbjct: 600 IGSASVSMVLSVNVPDVSRNGDPFVATSIVEAI 632



 Score = 29.6 bits (65), Expect = 3.4
 Identities = 22/83 (26%), Positives = 33/83 (39%), Gaps = 9/83 (10%)

Query: 141 SSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFD 200
           +  T GN    TC   +G+P  E  W ++      N  S +  S  + +     G L+  
Sbjct: 255 ADVTSGNTVYFTC-RAEGNPKPEIIWLRNN-----NELSMKTDSRLNLL---DDGTLMIQ 305

Query: 201 PLSASDTGEYSCEARNGYGTPMT 223
               +D G Y C A+N  G   T
Sbjct: 306 NTQETDQGIYQCMAKNVAGEVKT 328


>gi|121674801 hepatocyte cell adhesion molecule [Homo sapiens]
          Length = 416

 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 66/264 (25%), Positives = 103/264 (39%), Gaps = 28/264 (10%)

Query: 2   GTKAQVERKL-LCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPR- 59
           G  ++  R L L  F+  +L+ +  L  V + S    +         LS  YS  SS R 
Sbjct: 6   GALSRASRALRLAPFVYLLLIQTDPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDRP 65

Query: 60  -VEWKFDQGDTTRLVC-----YNNKITASYEDRVTFLPTG-ITFKSVTREDTGTYTCMVS 112
            V+W+  +     +V          +   Y DR+     G +    +   D GTY   +S
Sbjct: 66  VVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEIS 125

Query: 113 EEGGNSYGEVKVKLIVLVPPSKPTVNIPSSAT--IGNRAVLTCSEQDGSPPSEYTWFKDG 170
                  GE  + L V VP S+P V + S+    +     L CS ++G+ PS YTW KDG
Sbjct: 126 ITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPS-YTWLKDG 184

Query: 171 IVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN----GYGTPMTSNA 226
             +          ++S  +L+P    L    +   D   YSC   N    G   P+    
Sbjct: 185 KPL---------LNDSRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITV 235

Query: 227 VRMEA---VERNVGVIVAAVLVTL 247
            R  +   +    G+ +   LVT+
Sbjct: 236 YRRSSLYIILSTGGIFLLVTLVTV 259


>gi|139948432 adlican [Homo sapiens]
          Length = 2828

 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 40/189 (21%), Positives = 71/189 (37%), Gaps = 11/189 (5%)

Query: 32   HSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLP 91
            H  E + ++     +K+ C  +G  +P + W    G        ++      +  V F  
Sbjct: 2247 HKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN 2306

Query: 92   TGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVL 151
              + F  V   + G YTC    + G     V+VK++      +    +      G+   +
Sbjct: 2307 GTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTV 2366

Query: 152  TCSEQDGSPPSEYTWFK-DGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEY 210
             C E  G P  + TW      V+PT+ +  + + +         G L+      SD+G Y
Sbjct: 2367 AC-EAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD---------GTLLIQKAQRSDSGNY 2416

Query: 211  SCEARNGYG 219
            +C  RN  G
Sbjct: 2417 TCLVRNSAG 2425



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 50/176 (28%), Positives = 71/176 (40%), Gaps = 20/176 (11%)

Query: 48   LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
            + C   G  +PRV W F +G       Y N+IT             +  +S+ + D+   
Sbjct: 2464 IDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNG-------SLDIRSLRKSDSVQL 2516

Query: 108  TCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS----ATIGNRAVLTCSEQDGSPPSE 163
             CM   EGG +   + ++L VL P  KP  + P S    A  G+   L CS   G+P   
Sbjct: 2517 VCMARNEGGEA--RLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAA-GTPTPS 2573

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              W     V+P N    ++        +   G L    LS+ D G Y C ARN  G
Sbjct: 2574 LVW-----VLP-NGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAG 2623



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 47/187 (25%), Positives = 73/187 (39%), Gaps = 22/187 (11%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
            V++P  + V ++C   G   P+V W         L   N  I  S E    +    +  +
Sbjct: 2356 VQVPYGDVVTVACEAKGEPMPKVTW---------LSPTNKVIPTSSEKYQIYQDGTLLIQ 2406

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP----SKPTVNIPSSATIGNRAVLTC 153
               R D+G YTC+V    G     V + + V  P       P   +   A  G+R ++ C
Sbjct: 2407 KAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466

Query: 154  SEQDGSPPSEYTW-FKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSC 212
             + +G P     W F +G+V+P      R   + +       G L    L  SD+ +  C
Sbjct: 2467 -KAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGN-------GSLDIRSLRKSDSVQLVC 2518

Query: 213  EARNGYG 219
             ARN  G
Sbjct: 2519 MARNEGG 2525



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 42/176 (23%), Positives = 76/176 (43%), Gaps = 10/176 (5%)

Query: 46   VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITFKSVTREDT 104
            +KL C+ SG   PR+ W+     + R++        S++ R+     G +  KSVT +D 
Sbjct: 2164 LKLDCSASGDPWPRILWRLP---SKRMI----DALFSFDSRIKVFANGTLVVKSVTDKDA 2216

Query: 105  GTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEY 164
            G Y C+   + G+ Y  +KV +++     +           G    + C    G P  E 
Sbjct: 2217 GDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDC-VATGLPNPEI 2275

Query: 165  TW-FKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
            +W   DG ++ +  +S  +   +   +    G L F+ +   + G+Y+C A N  G
Sbjct: 2276 SWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG 2331



 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 46/181 (25%), Positives = 72/181 (39%), Gaps = 18/181 (9%)

Query: 42  ENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITFKSVT 100
           E  P +LSC      SP + W    G   +    +       + + + L +G +  KS+ 
Sbjct: 493 EGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDP------DSKFSILSSGWLRIKSME 546

Query: 101 REDTGTYTCM--VSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDG 158
             D+G Y C+  V +E       V V+     P  K TV I  +   G    L C+    
Sbjct: 547 PSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP--GESVTLPCNAL-A 603

Query: 159 SPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGY 218
            P +  +W     ++P N +     +N+S+V     G L    +  SD+G Y C A N  
Sbjct: 604 IPEAHLSW-----ILP-NRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQ 657

Query: 219 G 219
           G
Sbjct: 658 G 658



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 51/187 (27%), Positives = 71/187 (37%), Gaps = 19/187 (10%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITF 96
            V I     +KL C   G    R  W    G     +      T     RV+ L  G +T 
Sbjct: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNG-----MHLEGPQTLG---RVSLLDNGTLTV 2698

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP---SKPTVNIPSSATIGNRAVLTC 153
            +  +  D GTY C +  E G S   + V +++  PP   S+PT  I +    GN   L C
Sbjct: 2699 REASVFDRGTYVCRMETEYGPSVTSIPV-IVIAYPPRITSEPTPVIYTRP--GNTVKLNC 2755

Query: 154  SEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCE 213
                G P ++ TW              R + N    L+P  G L     +  D G Y C 
Sbjct: 2756 MAM-GIPKADITWELPDKSHLKAGVQARLYGNR--FLHP-QGSLTIQHATQRDAGFYKCM 2811

Query: 214  ARNGYGT 220
            A+N  G+
Sbjct: 2812 AKNILGS 2818



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 43/225 (19%), Positives = 84/225 (37%), Gaps = 26/225 (11%)

Query: 24   LALGSVTVHSSE------PEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNN 77
            + L SVTV   +       +V +   + + + C   G  +P++ W F      + V    
Sbjct: 1940 VVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVE 1999

Query: 78   KITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVP----PS 133
                 +E+R       ++ K  +  D G Y C+ S   G     +++ +  L P      
Sbjct: 2000 GRITLHENRT------LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEK 2053

Query: 134  KPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPT 193
               +++P   +I     + C+ +    PS      DG    T  + ++    + +V    
Sbjct: 2054 LENISLPPGLSIH----IHCTAKAAPLPSVRWVLGDG----TQIRPSQFLHGNLFVF--P 2103

Query: 194  TGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGV 238
             G L    L+  D+G Y C A N  G+   +  + ++    N  +
Sbjct: 2104 NGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARI 2148



 Score = 32.0 bits (71), Expect = 0.68
 Identities = 36/179 (20%), Positives = 63/179 (35%), Gaps = 15/179 (8%)

Query: 46   VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
            + L+C+ +G  +P + W    G   +      ++   Y      L        ++  D G
Sbjct: 2560 ISLNCSAAGTPTPSLVWVLPNGTDLQS---GQQLQRFYHKADGMLH----ISGLSSVDAG 2612

Query: 106  TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYT 165
             Y C+     G++   V +K+ +    +K   N+ S    G    L C+   G+    ++
Sbjct: 2613 AYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIIN-GETLKLPCTPP-GAGQGRFS 2670

Query: 166  WFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTS 224
            W     +    P++    S          G L     S  D G Y C     YG  +TS
Sbjct: 2671 WTLPNGMHLEGPQTLGRVSLLD------NGTLTVREASVFDRGTYVCRMETEYGPSVTS 2723



 Score = 29.6 bits (65), Expect = 3.4
 Identities = 39/140 (27%), Positives = 50/140 (35%), Gaps = 24/140 (17%)

Query: 94   ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS--------KPTVNIPSSATI 145
            I   S T+      T  V   G  S+ +   K     PP+        KP +   S  T+
Sbjct: 1806 IPMVSSTQSSISFITSSVQSSG--SFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTV 1863

Query: 146  GNRA----VLTCSEQDGSPPSEYTWFK--DGIVMPTNPKSTRAFSNSSYVLNPTTGELVF 199
               A    V  C E  G P    TW K   G +M  N +  R       VL    G LV 
Sbjct: 1864 SVTAETDTVFPC-EATGKPKPFVTWTKVSTGALMTPNTRIQRF-----EVLK--NGTLVI 1915

Query: 200  DPLSASDTGEYSCEARNGYG 219
              +   D G+Y C A N +G
Sbjct: 1916 RKVQVQDRGQYMCTASNLHG 1935


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 55/179 (30%), Positives = 79/179 (44%), Gaps = 30/179 (16%)

Query: 50   CAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYE-DRVTFLPTG-ITFKSVTREDTGTY 107
            C   G  SP V W         ++  N  +TA Y   R+T    G +  ++V   D+  +
Sbjct: 2261 CRAEGTPSPEVMW---------IMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADF 2311

Query: 108  TCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS----ATIGNRAVLTCSEQDGSPPSE 163
             C+   EGG S   + V+L VL    +PT   P +    A +G    L CS  DG+PP E
Sbjct: 2312 ICVARNEGGESV--LVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCS-VDGNPPPE 2368

Query: 164  YTW-FKDGIVMPTNPKSTRAF--SNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              W   +G      P+S +    SN S++++ TT E         D G+Y C ARN  G
Sbjct: 2369 IIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTRE---------DAGKYRCAARNKVG 2418



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 58/242 (23%), Positives = 94/242 (38%), Gaps = 27/242 (11%)

Query: 47   KLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYED----RVTFLPTG-ITFKSVTR 101
            ++ C  SG   P + W    G        NN + A        R T    G + F  V  
Sbjct: 2057 QVDCKASGSPVPEISWSLPDG-----TMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGV 2111

Query: 102  EDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPP 161
             + G YTC      G    +V + +I   P  + +         G+ AVL C E  G P 
Sbjct: 2112 AEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDC-EVTGDPK 2170

Query: 162  SEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTP 221
             +  W     ++P+N     +FS   Y  +   G L  + +   D+GEY C ARN  G  
Sbjct: 2171 PKIFW-----LLPSN--DMISFSIDRYTFH-ANGSLTINKVKLLDSGEYVCVARNPSGD- 2221

Query: 222  MTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYS 281
              +   +++ V +        ++  L     ++      +S+ HFD   +GT S +V++ 
Sbjct: 2222 -DTKMYKLDVVSK------PPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWI 2274

Query: 282  QP 283
             P
Sbjct: 2275 MP 2276



 Score = 51.6 bits (122), Expect = 8e-07
 Identities = 53/188 (28%), Positives = 77/188 (40%), Gaps = 23/188 (12%)

Query: 48   LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
            L+C+  G   P + W    G  TR     +    SY+  +    + I  K+ TRED G Y
Sbjct: 2357 LNCSVDGNPPPEIIWILPNG--TRF----SNGPQSYQYLIASNGSFIISKT-TREDAGKY 2409

Query: 108  TCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATI----GNRAVLTCSEQDGSPPSE 163
             C       N  G ++ KL++L    KP +   +  T+    G    L C   DG P   
Sbjct: 2410 RCAAR----NKVGYIE-KLVILEIGQKPVILTYAPGTVKGISGESLSLHCVS-DGIPKPN 2463

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMT 223
              W      MP+     R   N  Y+L+   G LV    +A D G Y C+A+N  G  + 
Sbjct: 2464 IKW-----TMPSGYVVDRPQINGKYILHDN-GTLVIKEATAYDRGNYICKAQNSVGHTLI 2517

Query: 224  SNAVRMEA 231
            +  V + A
Sbjct: 2518 TVPVMIVA 2525



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 48/194 (24%), Positives = 74/194 (38%), Gaps = 12/194 (6%)

Query: 37   EVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF 96
            E+ +   + V+L C   G  SP V W              ++ +      V  +   +  
Sbjct: 1754 EITVHSGSTVELKCRAEGRPSPTVTWILANQTVV------SESSQGSRQAVVTVDGTLVL 1807

Query: 97   KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQ 156
             +++  D G Y C+ S  GG     VK+++I   P            T G    L C+ +
Sbjct: 1808 HNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAK 1867

Query: 157  DGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
                PS Y    DG    T  K  + F+NS   L  + G L    L++SD G Y C A +
Sbjct: 1868 GTPQPSVYWVLSDG----TEVKPLQ-FTNSKLFLF-SNGTLYIRNLASSDRGTYECIATS 1921

Query: 217  GYGTPMTSNAVRME 230
              G+      + ME
Sbjct: 1922 STGSERRVVMLTME 1935



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 37/176 (21%), Positives = 67/176 (38%), Gaps = 14/176 (7%)

Query: 46   VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
            +KL C   G   P V W    G   + + + N     + +   ++      +++   D G
Sbjct: 1860 LKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYI------RNLASSDRG 1913

Query: 106  TYTCMVSEEGGNSYGEVKVKLI--VLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSE 163
            TY C+ +   G+    V + +   V  P  +      +    G++ +L CS   G P  +
Sbjct: 1914 TYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSAT-GEPKPQ 1972

Query: 164  YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
              W      +P+     +     S++     G L    ++  D+G Y C ARN  G
Sbjct: 1973 IMWR-----LPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG 2023



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 53/208 (25%), Positives = 86/208 (41%), Gaps = 28/208 (13%)

Query: 33   SSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPT 92
            S++   RI   +   L C  +G   P++ W             N+ I+ S  DR TF   
Sbjct: 2146 SNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPS---------NDMISFSI-DRYTFHAN 2195

Query: 93   G-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPP------SKPTVNIPSSATI 145
            G +T   V   D+G Y C+     G+     K+  +V  PP      +  TV I ++A  
Sbjct: 2196 GSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLD-VVSKPPLINGLYTNRTV-IKATAVR 2253

Query: 146  GNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSAS 205
             ++    C   +G+P  E  W     +MP N   T  +  S   ++   G L    +  S
Sbjct: 2254 HSKKHFDC-RAEGTPSPEVMW-----IMPDNIFLTAPYYGSRITVH-KNGTLEIRNVRLS 2306

Query: 206  DTGEYSCEARNGYGTPMTSNAVRMEAVE 233
            D+ ++ C ARN  G  +    V++E +E
Sbjct: 2307 DSADFICVARNEGGESVL--VVQLEVLE 2332



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 44/181 (24%), Positives = 64/181 (35%), Gaps = 14/181 (7%)

Query: 40   IPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITFKS 98
            IP N+   L C   G   P + W       TR+    +        RV  LP G ++ + 
Sbjct: 1660 IPANSDAFLPCEAVGNPLPTIHW-------TRVPSGLDLSKRKQNSRVQVLPNGTLSIQR 1712

Query: 99   VTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDG 158
            V  +D G Y C  S   G  +  V + ++   P          +   G+   L C   +G
Sbjct: 1713 VEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKC-RAEG 1771

Query: 159  SPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGY 218
             P    TW     ++      + +   S   +    G LV   LS  D G Y C A N  
Sbjct: 1772 RPSPTVTW-----ILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPG 1826

Query: 219  G 219
            G
Sbjct: 1827 G 1827



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 45/187 (24%), Positives = 68/187 (36%), Gaps = 17/187 (9%)

Query: 46   VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
            + L C   G   P ++W    G        N K      D  T     +  K  T  D G
Sbjct: 2450 LSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYIL--HDNGT-----LVIKEATAYDRG 2502

Query: 106  TYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAV--LTCSEQDGSPPSE 163
             Y C      G++   + V ++++  P + T   P S      A   L C    G P  E
Sbjct: 2503 NYICKAQNSVGHTL--ITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVAL-GVPKPE 2559

Query: 164  YTW-FKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPM 222
             TW   D  ++ T  K     S   ++     G LV      SD+G Y C A+N  G+  
Sbjct: 2560 ITWEMPDHSLLSTASKERTHGSEQLHL----QGTLVIQNPQTSDSGIYKCTAKNPLGSDY 2615

Query: 223  TSNAVRM 229
             +  +++
Sbjct: 2616 AATYIQV 2622



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 39/189 (20%), Positives = 77/189 (40%), Gaps = 10/189 (5%)

Query: 33   SSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPT 92
            +S+    +   + + L+C+ +G   P++ W+      ++ V        S+   +   P 
Sbjct: 1946 ASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP----SKAVVDQQHRVGSW---IHVYPN 1998

Query: 93   GITF-KSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVL 151
            G  F  SVT +D+G Y C+   + G+    + V L +                 G    +
Sbjct: 1999 GSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQV 2058

Query: 152  TCSEQDGSPPSEYTW-FKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEY 210
             C +  GSP  E +W   DG ++    ++  +   +        G L F+ +  ++ G+Y
Sbjct: 2059 DC-KASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDY 2117

Query: 211  SCEARNGYG 219
            +C A+N  G
Sbjct: 2118 TCYAQNTLG 2126



 Score = 35.8 bits (81), Expect = 0.047
 Identities = 42/175 (24%), Positives = 65/175 (37%), Gaps = 16/175 (9%)

Query: 46  VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITFKSVTREDT 104
           V L+C   G  +P V+W    G   R          S + R+    +G +  +     DT
Sbjct: 493 VGLNCPGQGDPTPHVDWLLADGSKVRAP------YVSEDGRILIDKSGKLELQMADSFDT 546

Query: 105 GTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEY 164
           G Y C+ S          ++ ++  +  +     I  +  IG    L C    G P +  
Sbjct: 547 GVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPC-HSTGIPDASI 605

Query: 165 TWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYG 219
           +W     V+P N    ++ S    VLN   G L    ++  D G Y C A N  G
Sbjct: 606 SW-----VIPGNNVLYQS-SRDKKVLN--NGTLRILQVTPKDQGYYRCVAANPSG 652


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 49/176 (27%), Positives = 69/176 (39%), Gaps = 23/176 (13%)

Query: 47  KLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF--KSVTREDT 104
           +L CA  G  +P++ W+ D G             A+ E R+  +P    F    V  ED 
Sbjct: 621 RLECAAVGHPAPQIAWQKDGG---------TDFPAARERRMHVMPEDDVFFIVDVKIEDI 671

Query: 105 GTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEY 164
           G Y+C      G+        L VL  PS     +  + T G  AVL C    GSPP + 
Sbjct: 672 GVYSCTAQNSAGSI--SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA-GGSPPPKL 728

Query: 165 TWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT 220
            W KD   +    +   A  N   ++  +           SD G+Y+CE  N  GT
Sbjct: 729 NWTKDDSPLVVTERHFFAAGNQLLIIVDS---------DVSDAGKYTCEMSNTLGT 775



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 39/135 (28%), Positives = 57/135 (42%), Gaps = 9/135 (6%)

Query: 92  TGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVL 151
           T +  + V     G Y C++S   G+SY  VK KL V + PS     +  +   G  A L
Sbjct: 564 TILRLREVEFASEGKYQCVISNHFGSSY-SVKAKLTVNMLPSFTKTPMDLTIRAGAMARL 622

Query: 152 TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
            C+   G P  +  W KDG           A     +V+ P         +   D G YS
Sbjct: 623 ECAAV-GHPAPQIAWQKDG-----GTDFPAARERRMHVM-PEDDVFFIVDVKIEDIGVYS 675

Query: 212 CEARNGYGTPMTSNA 226
           C A+N  G+ +++NA
Sbjct: 676 CTAQNSAGS-ISANA 689



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 22/94 (23%), Positives = 35/94 (37%), Gaps = 10/94 (10%)

Query: 48  LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
           L C   G   P++ W  D      LV       A+    +  + + ++       D G Y
Sbjct: 716 LQCIAGGSPPPKLNWTKDDSP---LVVTERHFFAAGNQLLIIVDSDVS-------DAGKY 765

Query: 108 TCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPS 141
           TC +S   G   G V++ +I       P +  PS
Sbjct: 766 TCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPS 799


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 49/176 (27%), Positives = 69/176 (39%), Gaps = 23/176 (13%)

Query: 47  KLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITF--KSVTREDT 104
           +L CA  G  +P++ W+ D G             A+ E R+  +P    F    V  ED 
Sbjct: 561 RLECAAVGHPAPQIAWQKDGG---------TDFPAARERRMHVMPEDDVFFIVDVKIEDI 611

Query: 105 GTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEY 164
           G Y+C      G+        L VL  PS     +  + T G  AVL C    GSPP + 
Sbjct: 612 GVYSCTAQNSAGSI--SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA-GGSPPPKL 668

Query: 165 TWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT 220
            W KD   +    +   A  N   ++  +           SD G+Y+CE  N  GT
Sbjct: 669 NWTKDDSPLVVTERHFFAAGNQLLIIVDS---------DVSDAGKYTCEMSNTLGT 715



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 39/135 (28%), Positives = 57/135 (42%), Gaps = 9/135 (6%)

Query: 92  TGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVL 151
           T +  + V     G Y C++S   G+SY  VK KL V + PS     +  +   G  A L
Sbjct: 504 TILRLREVEFASEGKYQCVISNHFGSSY-SVKAKLTVNMLPSFTKTPMDLTIRAGAMARL 562

Query: 152 TCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYS 211
            C+   G P  +  W KDG           A     +V+ P         +   D G YS
Sbjct: 563 ECAAV-GHPAPQIAWQKDG-----GTDFPAARERRMHVM-PEDDVFFIVDVKIEDIGVYS 615

Query: 212 CEARNGYGTPMTSNA 226
           C A+N  G+ +++NA
Sbjct: 616 CTAQNSAGS-ISANA 629



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 22/94 (23%), Positives = 35/94 (37%), Gaps = 10/94 (10%)

Query: 48  LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTY 107
           L C   G   P++ W  D      LV       A+    +  + + ++       D G Y
Sbjct: 656 LQCIAGGSPPPKLNWTKDDSP---LVVTERHFFAAGNQLLIIVDSDVS-------DAGKY 705

Query: 108 TCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPS 141
           TC +S   G   G V++ +I       P +  PS
Sbjct: 706 TCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPS 739


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
           precursor [Homo sapiens]
          Length = 2012

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 52/202 (25%), Positives = 82/202 (40%), Gaps = 23/202 (11%)

Query: 32  HSSEPEVRIPENNPVK-------------LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNK 78
           H S+  VR+P    V+             L+C+  G+  P + WKF +G           
Sbjct: 680 HQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQ---- 735

Query: 79  ITASYEDRVTFLPTG-ITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTV 137
              +   R+  L  G +  K V  ED+G Y C VS + G    +  + L V +P    + 
Sbjct: 736 -PIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSK-SMYLTVKIPAMITSY 793

Query: 138 NIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGEL 197
              + AT G +  ++C+   G  P    W K+  ++  NP+  R   ++  V       L
Sbjct: 794 PNTTLATQGQKKEMSCTAH-GEKPIIVRWEKEDRII--NPEMARYLVSTKEVGEEVISTL 850

Query: 198 VFDPLSASDTGEYSCEARNGYG 219
              P    D+G +SC A N YG
Sbjct: 851 QILPTVREDSGFFSCHAINSYG 872



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 42/172 (24%), Positives = 76/172 (44%), Gaps = 27/172 (15%)

Query: 46  VKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTG 105
           V+L C   G   P   W  D            +++  ++  VT    G+  +++   D+G
Sbjct: 242 VELPCKALGHPEPDYRWLKDNMPL--------ELSGRFQKTVT----GLLIENIRPSDSG 289

Query: 106 TYTCMVSEEGGNSYGEVKV-KLIVLVPPSKPTVNIPS-SATIGNRAVLTCSEQDGSPPSE 163
           +Y C VS    N YG  KV   + +  P K T++     +++G++  L+CS   G+   E
Sbjct: 290 SYVCEVS----NRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCS-VTGTEDQE 344

Query: 164 YTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEAR 215
            +W+++G ++  NP      +  ++        L+ D +  SD G Y C  R
Sbjct: 345 LSWYRNGEIL--NPGKNVRITGINH------ENLIMDHMVKSDGGAYQCFVR 388



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 43/195 (22%), Positives = 79/195 (40%), Gaps = 18/195 (9%)

Query: 38   VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFK 97
            V  P    + L C   G  SP V+W  D   T  LV  + +       R  F       +
Sbjct: 1295 VTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGR-------RSIFSNGSFIIR 1347

Query: 98   SVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQD 157
            +V  ED+G Y+C+ +   G+   E+ + L V VPP +P + +  S T  +   L+    D
Sbjct: 1348 TVKAEDSGYYSCIANNNWGSD--EIILNLQVQVPPDQPRLTV--SKTTSSSITLSWLPGD 1403

Query: 158  GSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNG 217
                S       G ++  +  ++  +   S+ ++P+      + L      +++  A+NG
Sbjct: 1404 NGGSS-----IRGYILQYSEDNSEQW--GSFPISPSERSYRLENLKCGTWYKFTLTAQNG 1456

Query: 218  YGTPMTSNAVRMEAV 232
             G    S  +  + +
Sbjct: 1457 VGPGRISEIIEAKTL 1471



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 47/170 (27%), Positives = 69/170 (40%), Gaps = 20/170 (11%)

Query: 48  LSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRE-DTGT 106
           + C   G+    ++W       + L+ +N++  A +E+  T     +    V +E D G 
Sbjct: 523 IHCRVIGYPYYSIKWY----KNSNLLPFNHRQVA-FENNGT-----LKLSDVQKEVDEGE 572

Query: 107 YTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTW 166
           YTC V  +   S  +  V + V VPP       P  + IG R  + C    G  P   TW
Sbjct: 573 YTCNVLVQPQLSTSQ-SVHVTVKVPPFIQPFEFPRFS-IGQRVFIPCVVVSGDLPITITW 630

Query: 167 FKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
            KDG  +P +   T    N  +     T  L    LS    G Y+C ARN
Sbjct: 631 QKDGRPIPGSLGVT--IDNIDF-----TSSLRISNLSLMHNGNYTCIARN 673



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 45/192 (23%), Positives = 76/192 (39%), Gaps = 27/192 (14%)

Query: 27  GSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFD-----QGDTTRLVCYNNKITA 81
           G+  + S+  E  +    PV L C   G   P + W  D     +G + R+    +++  
Sbjct: 405 GTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRI----SQMIT 460

Query: 82  SYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPS-KPTVNIP 140
           S  + V++L       S    D G Y C  +   G    + ++   V  P S +P  NI 
Sbjct: 461 SEGNVVSYL----NISSSQVRDGGVYRCTANNSAGVVLYQARIN--VRGPASIRPMKNI- 513

Query: 141 SSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFD 200
            +A  G    + C    G P     W+K+  ++P N +     +N +  L+    E+   
Sbjct: 514 -TAIAGRDTYIHC-RVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV--- 568

Query: 201 PLSASDTGEYSC 212
                D GEY+C
Sbjct: 569 -----DEGEYTC 575



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 23/78 (29%), Positives = 33/78 (42%), Gaps = 12/78 (15%)

Query: 143 ATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPL 202
           A  G R  L C    G P  +Y W KD + +  + +  +           T   L+ + +
Sbjct: 236 AMAGQRVELPCKAL-GHPEPDYRWLKDNMPLELSGRFQK-----------TVTGLLIENI 283

Query: 203 SASDTGEYSCEARNGYGT 220
             SD+G Y CE  N YGT
Sbjct: 284 RPSDSGSYVCEVSNRYGT 301



 Score = 37.0 bits (84), Expect = 0.021
 Identities = 32/142 (22%), Positives = 56/142 (39%), Gaps = 9/142 (6%)

Query: 85  DRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSAT 144
           D + F  + +   +++    G YTC+   E      E + +LIV VPP            
Sbjct: 646 DNIDFT-SSLRISNLSLMHNGNYTCIARNEAAAV--EHQSQLIVRVPPKFVVQPRDQDGI 702

Query: 145 IGNRAVLTCSEQDGSPPSEYTW-FKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLS 203
            G   +L CS  +G P     W F  G  +P      +  + +  +   + G L+   + 
Sbjct: 703 YGKAVILNCS-AEGYPVPTIVWKFSKGAGVP----QFQPIALNGRIQVLSNGSLLIKHVV 757

Query: 204 ASDTGEYSCEARNGYGTPMTSN 225
             D+G Y C+  N  G  ++ +
Sbjct: 758 EEDSGYYLCKVSNDVGADVSKS 779



 Score = 32.3 bits (72), Expect = 0.52
 Identities = 29/108 (26%), Positives = 41/108 (37%), Gaps = 13/108 (12%)

Query: 116  GNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMP- 174
            GNS   + V+ +   P    T +   +       VL C    G P     W KD    P 
Sbjct: 1270 GNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAV-GDPSPAVKWMKDSNGTPS 1328

Query: 175  --TNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGT 220
              T       FSN S+++           + A D+G YSC A N +G+
Sbjct: 1329 LVTIDGRRSIFSNGSFIIRT---------VKAEDSGYYSCIANNNWGS 1367


>gi|6005958 V-set and immunoglobulin domain containing 4 isoform 1
           [Homo sapiens]
          Length = 399

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 65/240 (27%), Positives = 100/240 (41%), Gaps = 41/240 (17%)

Query: 17  LAILLCSLALGSVTVHS-SEPEVRIPEN------NPVKLSCAYS---GFSSPRVEWKFDQ 66
           + ILL  L LG +TV +   P + +PE+        V L C Y    G++   V+W   +
Sbjct: 1   MGILLGLLLLGHLTVDTYGRPILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQR 60

Query: 67  GDTTRLVCYNNKI-----TASYEDRVTF---LPTGITFKSVTRE--DTGTYTCMVSEEGG 116
           G     +   +        A Y+ R+     +P  ++ +  T E  D   YTC V+ +  
Sbjct: 61  GSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQLSTLEMDDRSHYTCEVTWQTP 120

Query: 117 NSYGEVKVKLIVL----VPPSKPTVNIPS----SATIGNRAVLTCSEQDGSPPSEYTWFK 168
           +    V+ K+  L    +  SKPTV   S    +   G R  L C  + GSPP  Y W+K
Sbjct: 121 DGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFTVPQGMRISLQCQAR-GSPPISYIWYK 179

Query: 169 DGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVR 228
                 TN        N   +   T   L+F P   +D+G Y C A+   G+   S+ V+
Sbjct: 180 Q----QTN--------NQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVGSEQHSDIVK 227


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 52/201 (25%), Positives = 80/201 (39%), Gaps = 35/201 (17%)

Query: 28  SVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQG---DTTRLVCYNNKITASYE 84
           S  +   + EV I       L C  +G   P + W  D G   D +R V  ++       
Sbjct: 331 SFVIQPQDTEVLI--GTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSS------- 381

Query: 85  DRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVP-PSKPTVNIPSSA 143
                   G+  +++T+ D G +TC       NS+G V+    ++V  P + TV      
Sbjct: 382 --------GLYLQNITQRDHGRFTC----HANNSHGTVQAAANIIVQAPPQFTVTPKDQV 429

Query: 144 TIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLS 203
            +   AV    E DG+PP    W K G  +P   + T        VL  ++G L  D  +
Sbjct: 430 VLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHT--------VL--SSGTLRIDRAA 479

Query: 204 ASDTGEYSCEARNGYGTPMTS 224
             D G+Y C+A +  G    S
Sbjct: 480 QHDQGQYECQAVSSLGVKKVS 500



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 58/224 (25%), Positives = 86/224 (38%), Gaps = 43/224 (19%)

Query: 25  ALGSVTVH---------SSEPE-VRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVC 74
           A+ SVTV          + EP+ V +P  N V  +C   G   P + W          + 
Sbjct: 220 AVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIW----------IH 269

Query: 75  YNNKITASYEDRVTFLPTGITFKSVTRE-DTGTYTCMVSEEGGNSYGEVKVKLIVL---V 130
            N+ +    + R+     G      TRE D G Y CM      NS GE K +  +L    
Sbjct: 270 NNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMAR----NSAGEAKTQSAMLRYSS 325

Query: 131 PPSKPTVNIPSSAT---IGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSS 187
            P+KP+  I    T   IG    L C    G P    TW +D  +             S 
Sbjct: 326 LPAKPSFVIQPQDTEVLIGTSTTLECMAT-GHPHPLITWTRDNGL---------ELDGSR 375

Query: 188 YVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEA 231
           +V   T+  L    ++  D G ++C A N +GT   +  + ++A
Sbjct: 376 HVA--TSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 46/197 (23%), Positives = 73/197 (37%), Gaps = 32/197 (16%)

Query: 42  ENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTG-ITFKSVT 100
           E + V+  C   G   P + W    G                E + T L +G +      
Sbjct: 432 EEHAVEWLCEADGNPPPVIVWTKTGGQLP------------VEGQHTVLSSGTLRIDRAA 479

Query: 101 REDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTV--NIP--SSATIGNRAVLTCSEQ 156
           + D G Y C    +  +S G  KV + + V P    V   +P  +S  +G    ++C  Q
Sbjct: 480 QHDQGQYEC----QAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQ 535

Query: 157 DGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARN 216
            G P    TW K+G+ +          + S        G L        D G Y C ARN
Sbjct: 536 -GEPQPIITWNKEGVQI----------TESGKFHVDDEGTLTIYDAGFPDQGRYECVARN 584

Query: 217 GYGTPMTSNAVRMEAVE 233
            +G  +T+  + + A++
Sbjct: 585 SFGLAVTNMFLTVTAIQ 601


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,584,409
Number of Sequences: 37866
Number of extensions: 519967
Number of successful extensions: 4323
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 307
Number of HSP's that attempted gapping in prelim test: 1794
Number of HSP's gapped (non-prelim): 1823
length of query: 299
length of database: 18,247,518
effective HSP length: 102
effective length of query: 197
effective length of database: 14,385,186
effective search space: 2833881642
effective search space used: 2833881642
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.