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Search of human proteins with 71164875
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
(838 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 1702 0.0
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 1680 0.0
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 1630 0.0
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 1574 0.0
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 1034 0.0
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 1012 0.0
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 803 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 217 4e-56
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 217 4e-56
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 217 4e-56
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 217 4e-56
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 211 2e-54
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 211 2e-54
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 211 2e-54
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 211 2e-54
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 209 9e-54
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 209 9e-54
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 209 9e-54
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 208 2e-53
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 208 2e-53
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 179 9e-45
gi|4826894 phosphodiesterase 1C [Homo sapiens] 169 1e-41
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 164 3e-40
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 164 3e-40
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 164 3e-40
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 164 3e-40
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 164 3e-40
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 164 3e-40
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 164 3e-40
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens] 164 3e-40
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 1702 bits (4409), Expect = 0.0
Identities = 838/838 (100%), Positives = 838/838 (100%)
Query: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
Sbjct: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
Query: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
Sbjct: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
Query: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
Sbjct: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
Query: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
Sbjct: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
Query: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQEWQGVYYA 300
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQEWQGVYYA
Sbjct: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQEWQGVYYA 300
Query: 301 RRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHS 360
RRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHS
Sbjct: 301 RRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHS 360
Query: 361 FRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENS 420
FRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENS
Sbjct: 361 FRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENS 420
Query: 421 PVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNV 480
PVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNV
Sbjct: 421 PVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNV 480
Query: 481 HQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVC 540
HQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVC
Sbjct: 481 HQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVC 540
Query: 541 EFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVA 600
EFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVA
Sbjct: 541 EFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVA 600
Query: 601 ALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKN 660
ALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKN
Sbjct: 601 ALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKN 660
Query: 661 IDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPE 720
IDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPE
Sbjct: 661 IDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPE 720
Query: 721 NQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC 780
NQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC
Sbjct: 721 NQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC 780
Query: 781 SIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS 838
SIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
Sbjct: 781 SIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS 838
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 1680 bits (4351), Expect = 0.0
Identities = 838/885 (94%), Positives = 838/885 (94%), Gaps = 47/885 (5%)
Query: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
Sbjct: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
Query: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
Sbjct: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
Query: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
Sbjct: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
Query: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
Sbjct: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
Query: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQ-------- 292
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQ
Sbjct: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER 300
Query: 293 ---------------------------------------EWQGVYYARRKSGDSIQQHVK 313
EWQGVYYARRKSGDSIQQHVK
Sbjct: 301 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK 360
Query: 314 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV 373
ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
Sbjct: 361 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV 420
Query: 374 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE 433
KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
Sbjct: 421 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE 480
Query: 434 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI 493
ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
Sbjct: 481 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI 540
Query: 494 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW 553
NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
Sbjct: 541 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW 600
Query: 554 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP 613
FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
Sbjct: 601 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP 660
Query: 614 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI 673
GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
Sbjct: 661 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI 720
Query: 674 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA 733
IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
Sbjct: 721 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA 780
Query: 734 DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF 793
DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
Sbjct: 781 DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF 840
Query: 794 ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS 838
ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
Sbjct: 841 ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS 885
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 1630 bits (4222), Expect = 0.0
Identities = 818/885 (92%), Positives = 818/885 (92%), Gaps = 67/885 (7%)
Query: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
Sbjct: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
Query: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVK
Sbjct: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVK------- 113
Query: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
VLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
Sbjct: 114 -------------VLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 160
Query: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
Sbjct: 161 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 220
Query: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQ-------- 292
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQ
Sbjct: 221 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER 280
Query: 293 ---------------------------------------EWQGVYYARRKSGDSIQQHVK 313
EWQGVYYARRKSGDSIQQHVK
Sbjct: 281 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK 340
Query: 314 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV 373
ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
Sbjct: 341 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV 400
Query: 374 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE 433
KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
Sbjct: 401 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE 460
Query: 434 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI 493
ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
Sbjct: 461 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI 520
Query: 494 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW 553
NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
Sbjct: 521 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW 580
Query: 554 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP 613
FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
Sbjct: 581 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP 640
Query: 614 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI 673
GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
Sbjct: 641 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI 700
Query: 674 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA 733
IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
Sbjct: 701 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA 760
Query: 734 DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF 793
DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
Sbjct: 761 DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF 820
Query: 794 ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS 838
ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
Sbjct: 821 ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS 865
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 1574 bits (4076), Expect = 0.0
Identities = 788/838 (94%), Positives = 788/838 (94%), Gaps = 50/838 (5%)
Query: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
Sbjct: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
Query: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
Sbjct: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
Query: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
Sbjct: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
Query: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
Sbjct: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
Query: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQEWQGVYYA 300
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVI
Sbjct: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVI--------- 291
Query: 301 RRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHS 360
QIHKIHRDSGDNSQTEPHS
Sbjct: 292 -----------------------------------------QIHKIHRDSGDNSQTEPHS 310
Query: 361 FRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENS 420
FRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENS
Sbjct: 311 FRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENS 370
Query: 421 PVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNV 480
PVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNV
Sbjct: 371 PVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNV 430
Query: 481 HQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVC 540
HQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVC
Sbjct: 431 HQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVC 490
Query: 541 EFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVA 600
EFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVA
Sbjct: 491 EFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVA 550
Query: 601 ALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKN 660
ALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKN
Sbjct: 551 ALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKN 610
Query: 661 IDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPE 720
IDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPE
Sbjct: 611 IDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPE 670
Query: 721 NQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC 780
NQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC
Sbjct: 671 NQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC 730
Query: 781 SIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS 838
SIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
Sbjct: 731 SIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS 788
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 1034 bits (2673), Expect = 0.0
Identities = 523/842 (62%), Positives = 643/842 (76%), Gaps = 64/842 (7%)
Query: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
MGCAPSIH+S+ V ++++ SP S GP P Q A+P +R +G
Sbjct: 1 MGCAPSIHISERLV-----AEDAPSPAAPPLSSGGPRLP------QGQKTAALPRTRGAG 49
Query: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
+EL GS K+V+ A+V
Sbjct: 50 --------LLESELRDGSG---------------------------------KKVAVADV 68
Query: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
+ GPMR QD +QVLL+F KED+Q +GF AC++AG++C + + ++ L CFLDKHH+II
Sbjct: 69 QFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDII 128
Query: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
+IDHR + DAEA+CRSIR++ SE+TVI+ VV RV D EE SV+P + AGF RR++E
Sbjct: 129 IIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRV--DREELSVMPFISAGFTRRYVE 186
Query: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQEWQGVYYA 300
N +I+ACYNEL+Q+E GEVRSQ KLRACNSVFTAL++ +AIEITS+D IQEWQG+YYA
Sbjct: 187 NPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQEWQGIYYA 246
Query: 301 RRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHS 360
++K+GD+IQQ+VKI PVIGQGGKIRH+VS+ ++C + N + KI ++ T+ +
Sbjct: 247 KKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVC---NGNNKAEKISECVQSDTHTDNQT 303
Query: 361 FRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENS 420
++K+RRK S+DVK+++SR ++ S RR+ SMARIHSMTIEAPITKVINIINAAQE+S
Sbjct: 304 GKHKDRRKGSLDVKAVASRATEVSS--QRRHSSMARIHSMTIEAPITKVINIINAAQESS 361
Query: 421 PVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVF-TKN 479
P+ V EALDRVLEILRTTELYSPQ G KD+DPH +DLVGGLM+DGLRRLSGNEYV TKN
Sbjct: 362 PMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKN 421
Query: 480 VHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGV 539
S++ PI+++DVPP I++ ++NEE WDF+IFELEA TH RPL+YLGLK+F+RFG+
Sbjct: 422 TQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGI 481
Query: 540 CEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEV 599
CEFL+CSE+TLR+W Q+IEANYHSSN YHNSTH+ADVLHATA+FL KER+K +LD +DEV
Sbjct: 482 CEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEV 541
Query: 600 AALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFK 659
AALIAAT+HDVDHPGRTNSFLCNAGSELA+LYNDTAVLESHH ALAFQLT D KCNIFK
Sbjct: 542 AALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFK 601
Query: 660 NIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKN-- 717
N++RN YRTLRQ IIDMVLATEMTKHFEHVNKFVNSINKP+A E + + N N
Sbjct: 602 NMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTM 661
Query: 718 --FPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVF 775
PEN+ LIKRM+IKCADV+NPCRPL CIEWA RISEEYF+QTDEEK+QGLPVVMPVF
Sbjct: 662 LRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVF 721
Query: 776 DRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLP 835
DRNTCSIPKSQISFIDYFITDMFDAWDAF LP LMQHL +N+K+WK LD++K ++LR P
Sbjct: 722 DRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPP 781
Query: 836 SD 837
+
Sbjct: 782 PE 783
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 1012 bits (2616), Expect = 0.0
Identities = 523/888 (58%), Positives = 643/888 (72%), Gaps = 110/888 (12%)
Query: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
MGCAPSIH+S+ V ++++ SP S GP P Q A+P +R +G
Sbjct: 1 MGCAPSIHISERLV-----AEDAPSPAAPPLSSGGPRLP------QGQKTAALPRTRGAG 49
Query: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
+EL GS K+V+ A+V
Sbjct: 50 --------LLESELRDGSG---------------------------------KKVAVADV 68
Query: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
+ GPMR QD +QVLL+F KED+Q +GF AC++AG++C + + ++ L CFLDKHH+II
Sbjct: 69 QFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDII 128
Query: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
+IDHR + DAEA+CRSIR++ SE+TVI+ VV RV D EE SV+P + AGF RR++E
Sbjct: 129 IIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRV--DREELSVMPFISAGFTRRYVE 186
Query: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQ-------- 292
N +I+ACYNEL+Q+E GEVRSQ KLRACNSVFTAL++ +AIEITS+D IQ
Sbjct: 187 NPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFET 246
Query: 293 --------------------------------------EWQGVYYARRKSGDSIQQHVKI 314
EWQG+YYA++K+GD+IQQ+VKI
Sbjct: 247 TMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKI 306
Query: 315 TPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVK 374
PVIGQGGKIRH+VS+ ++C + N + KI ++ T+ + ++K+RRK S+DVK
Sbjct: 307 IPVIGQGGKIRHYVSIIRVC---NGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVK 363
Query: 375 SISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEI 434
+++SR ++ S RR+ SMARIHSMTIEAPITKVINIINAAQE+SP+ V EALDRVLEI
Sbjct: 364 AVASRATEVSS--QRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEI 421
Query: 435 LRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVF-TKNVHQSHSHLAMPITI 493
LRTTELYSPQ G KD+DPH +DLVGGLM+DGLRRLSGNEYV TKN S++ PI++
Sbjct: 422 LRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISL 481
Query: 494 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW 553
+DVPP I++ ++NEE WDF+IFELEA TH RPL+YLGLK+F+RFG+CEFL+CSE+TLR+W
Sbjct: 482 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 541
Query: 554 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP 613
Q+IEANYHSSN YHNSTH+ADVLHATA+FL KER+K +LD +DEVAALIAAT+HDVDHP
Sbjct: 542 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 601
Query: 614 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI 673
GRTNSFLCNAGSELA+LYNDTAVLESHH ALAFQLT D KCNIFKN++RN YRTLRQ I
Sbjct: 602 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 661
Query: 674 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKN----FPENQILIKRMM 729
IDMVLATEMTKHFEHVNKFVNSINKP+A E + + N N PEN+ LIKRM+
Sbjct: 662 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 721
Query: 730 IKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISF 789
IKCADV+NPCRPL CIEWA RISEEYF+QTDEEK+QGLPVVMPVFDRNTCSIPKSQISF
Sbjct: 722 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISF 781
Query: 790 IDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSD 837
IDYFITDMFDAWDAF LP LMQHL +N+K+WK LD++K ++LR P +
Sbjct: 782 IDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 803 bits (2074), Expect = 0.0
Identities = 408/455 (89%), Positives = 408/455 (89%), Gaps = 47/455 (10%)
Query: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
Sbjct: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
Query: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
Sbjct: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
Query: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
Sbjct: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
Query: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
Sbjct: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
Query: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQ-------- 292
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQ
Sbjct: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER 300
Query: 293 ---------------------------------------EWQGVYYARRKSGDSIQQHVK 313
EWQGVYYARRKSGDSIQQHVK
Sbjct: 301 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK 360
Query: 314 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV 373
ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
Sbjct: 361 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV 420
Query: 374 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITK 408
KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITK
Sbjct: 421 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITK 455
Score = 778 bits (2009), Expect = 0.0
Identities = 376/386 (97%), Positives = 379/386 (98%)
Query: 453 HTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDF 512
H+ + + DGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDF
Sbjct: 445 HSMTIEAPITKDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDF 504
Query: 513 NIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTH 572
NIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTH
Sbjct: 505 NIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTH 564
Query: 573 AADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN 632
AADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN
Sbjct: 565 AADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN 624
Query: 633 DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF 692
DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF
Sbjct: 625 DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF 684
Query: 693 VNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRI 752
VNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRI
Sbjct: 685 VNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRI 744
Query: 753 SEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQ 812
SEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQ
Sbjct: 745 SEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQ 804
Query: 813 HLADNYKHWKTLDDLKCKSLRLPSDS 838
HLADNYKHWKTLDDLKCKSLRLPSDS
Sbjct: 805 HLADNYKHWKTLDDLKCKSLRLPSDS 830
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 217 bits (552), Expect = 4e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
Query: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
Query: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 458 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
Query: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 736
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 517 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 566
Query: 737 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 796
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 567 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 625
Query: 797 MFDAWDAFAHLPA--LMQHLADNYKHW 821
+++ W A ++ L DN ++W
Sbjct: 626 LWETWADLVQPDAQDILDTLEDN-RNW 651
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 217 bits (552), Expect = 4e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 323 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 382
Query: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 383 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 442
Query: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 443 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 501
Query: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 736
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 502 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 551
Query: 737 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 796
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 552 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 610
Query: 797 MFDAWDAFAHLPA--LMQHLADNYKHW 821
+++ W A ++ L DN ++W
Sbjct: 611 LWETWADLVQPDAQDILDTLEDN-RNW 636
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 217 bits (552), Expect = 4e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 166 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 225
Query: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 226 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 285
Query: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 286 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 344
Query: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 736
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 345 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 394
Query: 737 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 796
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 395 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 453
Query: 797 MFDAWDAFAHLPA--LMQHLADNYKHW 821
+++ W A ++ L DN ++W
Sbjct: 454 LWETWADLVQPDAQDILDTLEDN-RNW 479
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 217 bits (552), Expect = 4e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
Query: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
Query: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 458 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
Query: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 736
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 517 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 566
Query: 737 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 796
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 567 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 625
Query: 797 MFDAWDAFAHLPA--LMQHLADNYKHW 821
+++ W A ++ L DN ++W
Sbjct: 626 LWETWADLVQPDAQDILDTLEDN-RNW 651
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 495 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 554
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 299 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 358
Query: 555 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 614
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 359 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 418
Query: 615 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 674
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 419 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 477
Query: 675 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 732
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 478 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 528
Query: 733 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 792
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 529 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 587
Query: 793 FITDMFDAWDAFAHLPA--LMQHLADN 817
+ +++ W H A ++ L DN
Sbjct: 588 IVHPLWETWADLVHPDAQEILDTLEDN 614
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 495 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 554
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 334 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 393
Query: 555 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 614
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 394 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 453
Query: 615 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 674
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 454 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 512
Query: 675 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 732
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 513 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 563
Query: 733 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 792
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 564 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 622
Query: 793 FITDMFDAWDAFAHLPA--LMQHLADN 817
+ +++ W H A ++ L DN
Sbjct: 623 IVHPLWETWADLVHPDAQEILDTLEDN 649
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 495 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 554
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 360 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 419
Query: 555 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 614
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 420 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 479
Query: 615 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 674
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 480 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 538
Query: 675 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 732
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 539 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 589
Query: 733 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 792
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 590 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 648
Query: 793 FITDMFDAWDAFAHLPA--LMQHLADN 817
+ +++ W H A ++ L DN
Sbjct: 649 IVHPLWETWADLVHPDAQEILDTLEDN 675
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 495 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 554
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 180
Query: 555 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 614
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 181 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 240
Query: 615 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 674
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 241 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 299
Query: 675 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 732
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 350
Query: 733 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 792
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 351 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 409
Query: 793 FITDMFDAWDAFAHLPA--LMQHLADN 817
+ +++ W H A ++ L DN
Sbjct: 410 IVHPLWETWADLVHPDAQEILDTLEDN 436
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 209 bits (532), Expect = 9e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 214 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 273
Query: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 274 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 333
Query: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 334 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 392
Query: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 739
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 393 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 445
Query: 740 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 799
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 446 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 504
Query: 800 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 837
W H A L+ L DN + W + K R PSD
Sbjct: 505 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 538
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 209 bits (532), Expect = 9e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 288 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 347
Query: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 348 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 407
Query: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 408 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 466
Query: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 739
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 467 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 519
Query: 740 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 799
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 520 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 578
Query: 800 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 837
W H A L+ L DN + W + K R PSD
Sbjct: 579 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 612
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 209 bits (532), Expect = 9e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 320 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 379
Query: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 380 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 439
Query: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 440 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 498
Query: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 739
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 499 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 551
Query: 740 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 799
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 552 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 610
Query: 800 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 837
W H A L+ L DN + W + K R PSD
Sbjct: 611 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 644
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 208 bits (529), Expect = 2e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 394 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 453
Query: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 454 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 513
Query: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 514 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 572
Query: 680 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 737
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 573 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 623
Query: 738 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 797
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 624 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 682
Query: 798 FDAWDAFAHLPA--LMQHLADNYKHW 821
++ W H A ++ L DN + W
Sbjct: 683 WETWADLVHPDAQDILDTLEDN-REW 707
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 208 bits (529), Expect = 2e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 258 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 317
Query: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 318 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 377
Query: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 378 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 436
Query: 680 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 737
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 437 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 487
Query: 738 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 797
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 488 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 546
Query: 798 FDAWDAFAHLPA--LMQHLADNYKHW 821
++ W H A ++ L DN + W
Sbjct: 547 WETWADLVHPDAQDILDTLEDN-REW 571
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 179 bits (454), Expect = 9e-45
Identities = 104/325 (32%), Positives = 175/325 (53%), Gaps = 20/325 (6%)
Query: 503 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 562
+L+ +W+F+IF + +T+ LV L +FS G+ E+ + LR + +I+ +YH
Sbjct: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
Query: 563 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 622
S N YHN+ HAADV A +L + ++ S+ D + +LIAA HD+DHPG FL
Sbjct: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
Query: 623 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 682
LA LY +T+VLE+HH A L + +F ++ + + I ++LAT++
Sbjct: 241 TNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSHLPLESRQQMETQIGALILATDI 297
Query: 683 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 742
++ E+++ F + +++ G C ++ L+ +M +KCAD+ NPCR
Sbjct: 298 SRQNEYLSLFRSHLDR-------GDLC------LEDTRHRHLVLQMALKCADICNPCRTW 344
Query: 743 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 802
+L +W+ +++EE+F Q D EK+ L V P+ DR+T SI QI F+ Y + +F W
Sbjct: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
Query: 803 AFAHL---PALMQHLADNYKHWKTL 824
F++ ++ H+ N WK L
Sbjct: 404 RFSNTRLSQTMLGHVGLNKASWKGL 428
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 169 bits (428), Expect = 1e-41
Identities = 91/303 (30%), Positives = 156/303 (51%), Gaps = 20/303 (6%)
Query: 497 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 556
PP + + L + + W F++F L + L ++ ++ +R+ + + L ++ +
Sbjct: 156 PPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEA 215
Query: 557 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 615
+E Y N YHN HAADV + L K V L +L+ A + +A +HD +H G
Sbjct: 216 LEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGT 275
Query: 616 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 675
TN+F S+ A+LYND +VLE+HH + A++L D + NI N+ ++ +R R +I+
Sbjct: 276 TNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIE 335
Query: 676 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 735
MV+AT+M+ HF+ + ++ +P A E P + +M+ AD+
Sbjct: 336 MVMATDMSCHFQQIKAMKTALQQPEAIE--------KPKALS----------LMLHTADI 377
Query: 736 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 795
++P + DL W + EE+F Q D E GLP P+ DR + + +SQ+ FID+ +
Sbjct: 378 SHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLP-FSPLCDRKSTMVAQSQVGFIDFIVE 436
Query: 796 DMF 798
F
Sbjct: 437 PTF 439
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 164 bits (415), Expect = 3e-40
Identities = 101/311 (32%), Positives = 164/311 (52%), Gaps = 24/311 (7%)
Query: 533 VFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGS 592
++ G+ + + TLR W + NY + N +HN H V + ++
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCSLQEK 129
Query: 593 LDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD 652
Q D + + AA HD+DHPG N++ NA +ELAV YND + LE+HH A+AFQ+ + +
Sbjct: 130 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI-LAE 188
Query: 653 TKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECN 712
+CNIF NI + ++ +RQ +I ++LAT+M +H E ++ F ++E D
Sbjct: 189 PECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF--------KEKMENFD---- 236
Query: 713 PAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVM 772
+ E+ L+K ++IKC D++N RP+++ W + EEYF Q+D EK +GLPV
Sbjct: 237 ---YSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVA- 292
Query: 773 PVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHL--PALMQHL---ADNYKHWKTLDDL 827
P DR+ + +QI FI + + MF+ + ++Q L D Y+ K +DD
Sbjct: 293 PFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDD- 351
Query: 828 KCKSLRLPSDS 838
K L+ +DS
Sbjct: 352 AMKELQKKTDS 362
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 164 bits (415), Expect = 3e-40
Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)
Query: 497 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 556
P + L + + W F++F L + + L ++ ++F+R+ + + L + +
Sbjct: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
Query: 557 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 615
+E Y N YHN HAADV + + + L +L+ +A + AA +HD +H G
Sbjct: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
Query: 616 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 675
TN+F S++A+LYND +VLE+HH + A++L +++ + NI N+ ++ +R LR +I+
Sbjct: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
Query: 676 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 735
MVL+T+M+ HF+ + NS+ +P EG D + +++ AD+
Sbjct: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
Query: 736 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 795
++P + L W + EE+F Q D+E GLP P+ DR + + +SQI FID+ +
Sbjct: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
Query: 796 DMF 798
F
Sbjct: 427 PTF 429
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 164 bits (415), Expect = 3e-40
Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)
Query: 497 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 556
P + L + + W F++F L + + L ++ ++F+R+ + + L + +
Sbjct: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
Query: 557 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 615
+E Y N YHN HAADV + + + L +L+ +A + AA +HD +H G
Sbjct: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
Query: 616 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 675
TN+F S++A+LYND +VLE+HH + A++L +++ + NI N+ ++ +R LR +I+
Sbjct: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
Query: 676 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 735
MVL+T+M+ HF+ + NS+ +P EG D + +++ AD+
Sbjct: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
Query: 736 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 795
++P + L W + EE+F Q D+E GLP P+ DR + + +SQI FID+ +
Sbjct: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
Query: 796 DMF 798
F
Sbjct: 427 PTF 429
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 164 bits (415), Expect = 3e-40
Identities = 101/311 (32%), Positives = 164/311 (52%), Gaps = 24/311 (7%)
Query: 533 VFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGS 592
++ G+ + + TLR W + NY + N +HN H V + ++
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCSLQEK 129
Query: 593 LDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD 652
Q D + + AA HD+DHPG N++ NA +ELAV YND + LE+HH A+AFQ+ + +
Sbjct: 130 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI-LAE 188
Query: 653 TKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECN 712
+CNIF NI + ++ +RQ +I ++LAT+M +H E ++ F ++E D
Sbjct: 189 PECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF--------KEKMENFD---- 236
Query: 713 PAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVM 772
+ E+ L+K ++IKC D++N RP+++ W + EEYF Q+D EK +GLPV
Sbjct: 237 ---YSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVA- 292
Query: 773 PVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHL--PALMQHL---ADNYKHWKTLDDL 827
P DR+ + +QI FI + + MF+ + ++Q L D Y+ K +DD
Sbjct: 293 PFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDD- 351
Query: 828 KCKSLRLPSDS 838
K L+ +DS
Sbjct: 352 AMKELQKKTDS 362
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 164 bits (415), Expect = 3e-40
Identities = 101/311 (32%), Positives = 164/311 (52%), Gaps = 24/311 (7%)
Query: 533 VFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGS 592
++ G+ + + TLR W + NY + N +HN H V + ++
Sbjct: 252 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCSLQEK 310
Query: 593 LDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD 652
Q D + + AA HD+DHPG N++ NA +ELAV YND + LE+HH A+AFQ+ + +
Sbjct: 311 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI-LAE 369
Query: 653 TKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECN 712
+CNIF NI + ++ +RQ +I ++LAT+M +H E ++ F ++E D
Sbjct: 370 PECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF--------KEKMENFD---- 417
Query: 713 PAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVM 772
+ E+ L+K ++IKC D++N RP+++ W + EEYF Q+D EK +GLPV
Sbjct: 418 ---YSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVA- 473
Query: 773 PVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHL--PALMQHL---ADNYKHWKTLDDL 827
P DR+ + +QI FI + + MF+ + ++Q L D Y+ K +DD
Sbjct: 474 PFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDD- 532
Query: 828 KCKSLRLPSDS 838
K L+ +DS
Sbjct: 533 AMKELQKKTDS 543
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 164 bits (415), Expect = 3e-40
Identities = 101/311 (32%), Positives = 164/311 (52%), Gaps = 24/311 (7%)
Query: 533 VFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGS 592
++ G+ + + TLR W + NY + N +HN H V + ++
Sbjct: 237 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCSLQEK 295
Query: 593 LDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD 652
Q D + + AA HD+DHPG N++ NA +ELAV YND + LE+HH A+AFQ+ + +
Sbjct: 296 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI-LAE 354
Query: 653 TKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECN 712
+CNIF NI + ++ +RQ +I ++LAT+M +H E ++ F ++E D
Sbjct: 355 PECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF--------KEKMENFD---- 402
Query: 713 PAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVM 772
+ E+ L+K ++IKC D++N RP+++ W + EEYF Q+D EK +GLPV
Sbjct: 403 ---YSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVA- 458
Query: 773 PVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHL--PALMQHL---ADNYKHWKTLDDL 827
P DR+ + +QI FI + + MF+ + ++Q L D Y+ K +DD
Sbjct: 459 PFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDD- 517
Query: 828 KCKSLRLPSDS 838
K L+ +DS
Sbjct: 518 AMKELQKKTDS 528
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 164 bits (415), Expect = 3e-40
Identities = 101/311 (32%), Positives = 164/311 (52%), Gaps = 24/311 (7%)
Query: 533 VFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGS 592
++ G+ + + TLR W + NY + N +HN H V + ++
Sbjct: 211 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCSLQEK 269
Query: 593 LDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD 652
Q D + + AA HD+DHPG N++ NA +ELAV YND + LE+HH A+AFQ+ + +
Sbjct: 270 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI-LAE 328
Query: 653 TKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECN 712
+CNIF NI + ++ +RQ +I ++LAT+M +H E ++ F ++E D
Sbjct: 329 PECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF--------KEKMENFD---- 376
Query: 713 PAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVM 772
+ E+ L+K ++IKC D++N RP+++ W + EEYF Q+D EK +GLPV
Sbjct: 377 ---YSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVA- 432
Query: 773 PVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHL--PALMQHL---ADNYKHWKTLDDL 827
P DR+ + +QI FI + + MF+ + ++Q L D Y+ K +DD
Sbjct: 433 PFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDD- 491
Query: 828 KCKSLRLPSDS 838
K L+ +DS
Sbjct: 492 AMKELQKKTDS 502
>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 164 bits (415), Expect = 3e-40
Identities = 101/311 (32%), Positives = 164/311 (52%), Gaps = 24/311 (7%)
Query: 533 VFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGS 592
++ G+ + + TLR W + NY + N +HN H V + ++
Sbjct: 61 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCSLQEK 119
Query: 593 LDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD 652
Q D + + AA HD+DHPG N++ NA +ELAV YND + LE+HH A+AFQ+ + +
Sbjct: 120 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI-LAE 178
Query: 653 TKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECN 712
+CNIF NI + ++ +RQ +I ++LAT+M +H E ++ F ++E D
Sbjct: 179 PECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF--------KEKMENFD---- 226
Query: 713 PAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVM 772
+ E+ L+K ++IKC D++N RP+++ W + EEYF Q+D EK +GLPV
Sbjct: 227 ---YSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVA- 282
Query: 773 PVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHL--PALMQHL---ADNYKHWKTLDDL 827
P DR+ + +QI FI + + MF+ + ++Q L D Y+ K +DD
Sbjct: 283 PFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDD- 341
Query: 828 KCKSLRLPSDS 838
K L+ +DS
Sbjct: 342 AMKELQKKTDS 352
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.132 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,338,070
Number of Sequences: 37866
Number of extensions: 1392743
Number of successful extensions: 6015
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 5688
Number of HSP's gapped (non-prelim): 197
length of query: 838
length of database: 18,247,518
effective HSP length: 111
effective length of query: 727
effective length of database: 14,044,392
effective search space: 10210272984
effective search space used: 10210272984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.