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Search of human proteins with 70909324
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|70909324 sperm associated antigen 16 isoform 1 [Homo
sapiens]
(631 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 1296 0.0
gi|70887780 sperm associated antigen 16 isoform 2 [Homo sapiens] 354 2e-97
gi|26665869 WD repeat domain 51B [Homo sapiens] 143 5e-34
gi|32189425 WD repeat domain 69 [Homo sapiens] 140 5e-33
gi|16554629 WD repeat domain 5 [Homo sapiens] 138 2e-32
gi|16554627 WD repeat domain 5 [Homo sapiens] 138 2e-32
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 132 1e-30
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 132 1e-30
gi|23199987 WD repeat domain 5B [Homo sapiens] 129 1e-29
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 125 1e-28
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 120 5e-27
gi|113865883 WD repeat domain 38 [Homo sapiens] 119 6e-27
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 115 9e-26
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 115 9e-26
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 115 1e-25
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 110 4e-24
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 110 4e-24
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 110 4e-24
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 108 1e-23
gi|21071067 TBP-associated factor 5 [Homo sapiens] 108 2e-23
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 105 1e-22
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 105 1e-22
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 102 8e-22
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 102 1e-21
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 100 4e-21
gi|4757988 WD repeat domain 39 [Homo sapiens] 99 9e-21
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 99 9e-21
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 99 2e-20
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 99 2e-20
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 98 2e-20
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 1296 bits (3353), Expect = 0.0
Identities = 631/631 (100%), Positives = 631/631 (100%)
Query: 1 MAAQRGMPSSAVRVLEEALGMGLTAAGDARDTADAVAAEGAYYLEQVTITEASEDDYEYE 60
MAAQRGMPSSAVRVLEEALGMGLTAAGDARDTADAVAAEGAYYLEQVTITEASEDDYEYE
Sbjct: 1 MAAQRGMPSSAVRVLEEALGMGLTAAGDARDTADAVAAEGAYYLEQVTITEASEDDYEYE 60
Query: 61 EIPDDNFSIPEGEEDLAKAIQMAQEQATDTEILERKTVLPSKHAVPEVIEDFLCNFLIKM 120
EIPDDNFSIPEGEEDLAKAIQMAQEQATDTEILERKTVLPSKHAVPEVIEDFLCNFLIKM
Sbjct: 61 EIPDDNFSIPEGEEDLAKAIQMAQEQATDTEILERKTVLPSKHAVPEVIEDFLCNFLIKM 120
Query: 121 GMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAADK 180
GMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAADK
Sbjct: 121 GMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAADK 180
Query: 181 AREDLLKIQKERDFHRMHHKRIVQEKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKE 240
AREDLLKIQKERDFHRMHHKRIVQEKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKE
Sbjct: 181 AREDLLKIQKERDFHRMHHKRIVQEKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKE 240
Query: 241 KMLTSLERDKVVGQISGLQETLKKLQRGHSYHGPQIKVDHSREKENAPEGPTQKGLREAR 300
KMLTSLERDKVVGQISGLQETLKKLQRGHSYHGPQIKVDHSREKENAPEGPTQKGLREAR
Sbjct: 241 KMLTSLERDKVVGQISGLQETLKKLQRGHSYHGPQIKVDHSREKENAPEGPTQKGLREAR 300
Query: 301 EQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSM 360
EQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSM
Sbjct: 301 EQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSM 360
Query: 361 QPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKL 420
QPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKL
Sbjct: 361 QPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKL 420
Query: 421 WDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDS 480
WDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDS
Sbjct: 421 WDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDS 480
Query: 481 VNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDA 540
VNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDA
Sbjct: 481 VNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDA 540
Query: 541 CGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLM 600
CGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLM
Sbjct: 541 CGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLM 600
Query: 601 GHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
GHENEAHTVVFSHDGEILFSGGSDGTVRTWS
Sbjct: 601 GHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
>gi|70887780 sperm associated antigen 16 isoform 2 [Homo sapiens]
Length = 183
Score = 354 bits (908), Expect = 2e-97
Identities = 178/179 (99%), Positives = 179/179 (100%)
Query: 1 MAAQRGMPSSAVRVLEEALGMGLTAAGDARDTADAVAAEGAYYLEQVTITEASEDDYEYE 60
MAAQRGMPSSAVRVLEEALGMGLTAAGDARDTADAVAAEGAYYLEQVTITEASEDDYEYE
Sbjct: 1 MAAQRGMPSSAVRVLEEALGMGLTAAGDARDTADAVAAEGAYYLEQVTITEASEDDYEYE 60
Query: 61 EIPDDNFSIPEGEEDLAKAIQMAQEQATDTEILERKTVLPSKHAVPEVIEDFLCNFLIKM 120
EIPDDNFSIPEGEEDLAKAIQMAQEQATDTEILERKTVLPSKHAVPEVIEDFLCNFLIKM
Sbjct: 61 EIPDDNFSIPEGEEDLAKAIQMAQEQATDTEILERKTVLPSKHAVPEVIEDFLCNFLIKM 120
Query: 121 GMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAAD 179
GMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAA+
Sbjct: 121 GMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAAE 179
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 143 bits (360), Expect = 5e-34
Identities = 94/299 (31%), Positives = 143/299 (47%), Gaps = 5/299 (1%)
Query: 335 LSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHT 394
++ A D L+ F+ H+ ++ + + P+ L + D + GH
Sbjct: 1 MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK 60
Query: 395 DWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASS 454
D ++ F P G+ LA++S D TV+LW K F+ H+ V S + + G F+A++
Sbjct: 61 DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA 120
Query: 455 SLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQ 514
S DK+ K+W + +R +LY HT V +F P +++ S DKT+ IWD C
Sbjct: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
Query: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSIDIGPSPGNEVNFDS 572
+ + N F+P G IAS + K+WD R KLL + G N ++F
Sbjct: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGV--NCISFHP 238
Query: 573 SGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
SG L AS +G + +LDL G I+ L GH TV FS GE+ SGG+D V W
Sbjct: 239 SGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 95.5 bits (236), Expect = 1e-19
Identities = 62/248 (25%), Positives = 107/248 (43%), Gaps = 2/248 (0%)
Query: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGF-GHTDWLSDCCFHPSGDKL 409
H+ V+ V PH ++L S DR + L +P + F HT + F G L
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVR-LWIPDKRGKFSEFKAHTAPVRSVDFSADGQFL 117
Query: 410 ATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSER 469
AT+S D ++K+W + + + + H+ V + G + S S DKT KIWD +++
Sbjct: 118 ATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ 177
Query: 470 CRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFD 529
C N ++F P + ++ +D+T+ +WD R Q H +N F
Sbjct: 178 CVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFH 237
Query: 530 PRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLL 589
P G+ + + + G K+ D + I ++ P V+F G + A + + L
Sbjct: 238 PSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Query: 590 DLKSGEIH 597
E+H
Sbjct: 298 RTNFDELH 305
Score = 62.8 bits (151), Expect = 9e-10
Identities = 37/116 (31%), Positives = 58/116 (50%), Gaps = 2/116 (1%)
Query: 358 VSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFG-HTDWLSDCCFHPSGDKLATSSGDT 416
V P + S G D+ KV + + N LL + H+ ++ FHPSG+ L T+S D
Sbjct: 192 VDFNPSGTCIASAGSDQTVKVWDV-RVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDG 250
Query: 417 TVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRC 472
T+K+ DL +G I T +GH+ V++ ++ G AS D +W N + C
Sbjct: 251 TLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHC 306
Score = 46.2 bits (108), Expect = 9e-05
Identities = 30/122 (24%), Positives = 49/122 (40%), Gaps = 1/122 (0%)
Query: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF 570
+ E+ GH +I P G +A+ LW+F+ V F
Sbjct: 9 VLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQF 68
Query: 571 DSSGRVLAQASGNGVIHL-LDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRT 629
G +LA AS + + L + K G+ + H +V FS DG+ L + D +++
Sbjct: 69 SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 630 WS 631
WS
Sbjct: 129 WS 130
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 140 bits (352), Expect = 5e-33
Identities = 80/270 (29%), Positives = 134/270 (49%), Gaps = 1/270 (0%)
Query: 362 PHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLW 421
P+ D + + D+ K+ + T GHT + F+P +AT S DTT KLW
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204
Query: 422 DLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSV 481
D+ G+ + T GHS + S ++++ G+ + + S D T +WD ++ R L GH +
Sbjct: 205 DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264
Query: 482 NSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC 541
+S F + +LT S DKT +WDA G C +L GH I D+ FD G +IA+ A
Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASAD 324
Query: 542 GVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHKLM 600
G +++ I ++ ++++F+ G L S + + D ++G+ + L
Sbjct: 325 GTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLE 384
Query: 601 GHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
GH +E + F++ G I+ +G D T R W
Sbjct: 385 GHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 139 bits (349), Expect = 1e-32
Identities = 88/291 (30%), Positives = 141/291 (48%), Gaps = 2/291 (0%)
Query: 342 YKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCC 401
+ L + + H LP++ V++ ++ DR K+ L T GH + +
Sbjct: 82 FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIA 141
Query: 402 FH-PSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTS 460
F+ P GDK+AT S D T KLW + G C TF GH+ + +++ VA+ S+D T+
Sbjct: 142 FNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTA 201
Query: 461 KIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHM 520
K+WD+ + TL GH+ + S+ F + ++T S D T+ +WDA TG L GH
Sbjct: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261
Query: 521 HSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQA 580
I+ A F+ +I + KLWD + ++ + FD +G+++A A
Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321
Query: 581 SGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
S +G + + + I KL GHE E + F+ G L +G SD T R W
Sbjct: 322 SADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Score = 89.0 bits (219), Expect = 1e-17
Identities = 49/160 (30%), Positives = 77/160 (48%)
Query: 346 NIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPS 405
NI H +S S ++++ D+ K+ + T GH D + D CF +
Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
Query: 406 GDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDV 465
G +AT+S D T +++ CI EGH + +++ GN + + S DKT++IWD
Sbjct: 315 GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374
Query: 466 NSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIW 505
+ +C L GHTD + S F N ++T S D T IW
Sbjct: 375 QTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 138 bits (347), Expect = 2e-32
Identities = 89/315 (28%), Positives = 152/315 (48%), Gaps = 7/315 (2%)
Query: 323 QPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLP 382
QP P+ + ++ +P K +Y LK H VS V P+ + L S D+L K+ G
Sbjct: 16 QPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY 75
Query: 383 KCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSC 442
T GH +SD + + L ++S D T+K+WD+ G C+ T +GHS V+ C
Sbjct: 76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
Query: 443 TWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTL 502
++ N + S S D++ +IWDV + +C TL H+D V+++ F + +++SS D
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 503 SIWDARTGICEQSLYGHMH-SINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSID 559
IWD +G C ++L + ++ F P G I + KLWD+ K L +
Sbjct: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255
Query: 560 IGPSPGNEVNFD-SSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEI 617
NF + G+ + S + ++++ +L++ EI KL GH + + I
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315
Query: 618 LFSGG--SDGTVRTW 630
+ S +D T++ W
Sbjct: 316 IASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 138 bits (347), Expect = 2e-32
Identities = 89/315 (28%), Positives = 152/315 (48%), Gaps = 7/315 (2%)
Query: 323 QPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLP 382
QP P+ + ++ +P K +Y LK H VS V P+ + L S D+L K+ G
Sbjct: 16 QPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY 75
Query: 383 KCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSC 442
T GH +SD + + L ++S D T+K+WD+ G C+ T +GHS V+ C
Sbjct: 76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
Query: 443 TWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTL 502
++ N + S S D++ +IWDV + +C TL H+D V+++ F + +++SS D
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 503 SIWDARTGICEQSLYGHMH-SINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSID 559
IWD +G C ++L + ++ F P G I + KLWD+ K L +
Sbjct: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255
Query: 560 IGPSPGNEVNFD-SSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEI 617
NF + G+ + S + ++++ +L++ EI KL GH + + I
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315
Query: 618 LFSGG--SDGTVRTW 630
+ S +D T++ W
Sbjct: 316 IASAALENDKTIKLW 330
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 132 bits (332), Expect = 1e-30
Identities = 91/297 (30%), Positives = 137/297 (46%), Gaps = 3/297 (1%)
Query: 336 SPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTD 395
+P D L+ F+ H V+CV + L S D V + + GH D
Sbjct: 3 APCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD 62
Query: 396 WLSDCCFHPSGDKLATSSGDTTVKLW-DLCKGDCILTFEGHSRAVWSCTWHSCGNFVASS 454
++ F PSG LA+ S D TV++W KG+ + F H+ V S + S G ++
Sbjct: 63 AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV-FRAHTATVRSVHFCSDGQSFVTA 121
Query: 455 SLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQ 514
S DKT K+W + ++ +L H + V +F P ++++S DKT+ +WD + C
Sbjct: 122 SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 181
Query: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSG 574
S H + F P G IA+ K+WD R + + + N ++F SG
Sbjct: 182 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
Query: 575 RVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
L AS + + +LDL G ++ L GH+ A TV FS GE SGGSD V W
Sbjct: 242 NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 76.6 bits (187), Expect = 6e-14
Identities = 42/159 (26%), Positives = 76/159 (47%)
Query: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
V C P ++VS +D+ K+ + + H +++ FHPSG +A +
Sbjct: 148 VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM 207
Query: 415 DTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
D TVK+WD+ + ++ HS AV ++H GN++ ++S D T KI D+ R TL
Sbjct: 208 DNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267
Query: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICE 513
+GH ++ F + +D+ + +W + I +
Sbjct: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 306
Score = 35.4 bits (80), Expect = 0.16
Identities = 32/157 (20%), Positives = 52/157 (33%), Gaps = 43/157 (27%)
Query: 476 GHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMI 535
GH D+V ++F + L + S D L +W + GH ++
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV------------ 64
Query: 536 ASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHL-LDLKSG 594
+C VNF SG +LA S + + + + G
Sbjct: 65 -TC-----------------------------VNFSPSGHLLASGSRDKTVRIWVPNVKG 94
Query: 595 EIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
E H +V F DG+ + D TV+ W+
Sbjct: 95 ESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 132 bits (332), Expect = 1e-30
Identities = 91/297 (30%), Positives = 137/297 (46%), Gaps = 3/297 (1%)
Query: 336 SPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTD 395
+P D L+ F+ H V+CV + L S D V + + GH D
Sbjct: 3 APCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD 62
Query: 396 WLSDCCFHPSGDKLATSSGDTTVKLW-DLCKGDCILTFEGHSRAVWSCTWHSCGNFVASS 454
++ F PSG LA+ S D TV++W KG+ + F H+ V S + S G ++
Sbjct: 63 AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV-FRAHTATVRSVHFCSDGQSFVTA 121
Query: 455 SLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQ 514
S DKT K+W + ++ +L H + V +F P ++++S DKT+ +WD + C
Sbjct: 122 SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 181
Query: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSG 574
S H + F P G IA+ K+WD R + + + N ++F SG
Sbjct: 182 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
Query: 575 RVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
L AS + + +LDL G ++ L GH+ A TV FS GE SGGSD V W
Sbjct: 242 NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 76.6 bits (187), Expect = 6e-14
Identities = 42/159 (26%), Positives = 76/159 (47%)
Query: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
V C P ++VS +D+ K+ + + H +++ FHPSG +A +
Sbjct: 148 VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM 207
Query: 415 DTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
D TVK+WD+ + ++ HS AV ++H GN++ ++S D T KI D+ R TL
Sbjct: 208 DNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267
Query: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICE 513
+GH ++ F + +D+ + +W + I +
Sbjct: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 306
Score = 35.4 bits (80), Expect = 0.16
Identities = 32/157 (20%), Positives = 52/157 (33%), Gaps = 43/157 (27%)
Query: 476 GHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMI 535
GH D+V ++F + L + S D L +W + GH ++
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV------------ 64
Query: 536 ASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHL-LDLKSG 594
+C VNF SG +LA S + + + + G
Sbjct: 65 -TC-----------------------------VNFSPSGHLLASGSRDKTVRIWVPNVKG 94
Query: 595 EIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
E H +V F DG+ + D TV+ W+
Sbjct: 95 ESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 129 bits (323), Expect = 1e-29
Identities = 91/310 (29%), Positives = 148/310 (47%), Gaps = 11/310 (3%)
Query: 329 NVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLL 388
N SKE P +Y LK H VS V P+ + L S DRL + G
Sbjct: 20 NQSKEV--PENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEK 77
Query: 389 TGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCG 448
T +GH +SD + +L ++S D T+KLWD+ G C+ T +GHS V+ C ++
Sbjct: 78 TLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137
Query: 449 NFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDAR 508
N + S S D+T KIW+V + +C TL H+D V+++ F + +++ S D IWDA
Sbjct: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 509 TGICEQSLYGHMH-SINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSIDIGPSPG 565
+G C ++L + ++ F P G I + KLWD+ + L +
Sbjct: 198 SGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYC 257
Query: 566 NEVNFD-SSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILFSGG- 622
NF + G+ + S + ++++ +L++ EI KL GH + + H E L +
Sbjct: 258 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAA-CHPTENLIASAA 316
Query: 623 --SDGTVRTW 630
+D T++ W
Sbjct: 317 LENDKTIKLW 326
Score = 88.6 bits (218), Expect = 2e-17
Identities = 52/179 (29%), Positives = 91/179 (50%), Gaps = 1/179 (0%)
Query: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512
SSS +++ ++ + + +CTL GHT++V+S++F P L +SSAD+ + IW A G
Sbjct: 16 SSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKY 75
Query: 513 EQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDS 572
E++LYGH I+D + + S KLWD R + ++ + NF+
Sbjct: 76 EKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP 135
Query: 573 SGRVLAQASGNGVIHLLDLKSGEIHK-LMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
++ S + + + ++K+G+ K L H + V F+ G ++ SG DG R W
Sbjct: 136 PSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 52.4 bits (124), Expect = 1e-06
Identities = 38/143 (26%), Positives = 68/143 (47%), Gaps = 11/143 (7%)
Query: 494 LTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLW-----D 548
L+SSA+++ + + + +L GH +++ F P G +AS A + +W
Sbjct: 15 LSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGK 74
Query: 549 FRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHK-LMGHENEAH 607
+ K L +++I ++V + S L AS + + L D++SG+ K L GH N
Sbjct: 75 YEKTLYGHNLEI-----SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVF 129
Query: 608 TVVFSHDGEILFSGGSDGTVRTW 630
F+ ++ SG D TV+ W
Sbjct: 130 CCNFNPPSNLIISGSFDETVKIW 152
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 125 bits (314), Expect = 1e-28
Identities = 79/241 (32%), Positives = 118/241 (48%), Gaps = 3/241 (1%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLW-DLCKGDCILTFEGHSRAVWSCTWHSCGNF 450
GH D ++ F PSG LA+ S D TV++W KG+ + F H+ V S + S G
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV-FRAHTATVRSVHFCSDGQS 79
Query: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
++S DKT K+W + ++ +L H + V +F P ++++S DKT+ +WD +
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
Query: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF 570
C S H + F P G IA+ K+WD R + + + N ++F
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 199
Query: 571 DSSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRT 629
SG L AS + + +LDL G ++ L GH+ A TV FS GE SGGSD V
Sbjct: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259
Query: 630 W 630
W
Sbjct: 260 W 260
Score = 103 bits (257), Expect = 5e-22
Identities = 59/201 (29%), Positives = 91/201 (45%)
Query: 347 IFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSG 406
+FR H V V V+ +D+ KV + L + H +W+ F P G
Sbjct: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 407 DKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVN 466
+ ++S D TVKLWD +C+ ++ H V +H G +A++ +D T K+WDV
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Query: 467 SERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDA 526
+ R H+ +VN + F P N L+T+S+D TL I D G +L+GH
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 239
Query: 527 IFDPRGHMIASCDACGVTKLW 547
F G AS + +W
Sbjct: 240 AFSRTGEYFASGGSDEQVMVW 260
Score = 76.6 bits (187), Expect = 6e-14
Identities = 42/159 (26%), Positives = 76/159 (47%)
Query: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
V C P ++VS +D+ K+ + + H +++ FHPSG +A +
Sbjct: 110 VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM 169
Query: 415 DTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
D TVK+WD+ + ++ HS AV ++H GN++ ++S D T KI D+ R TL
Sbjct: 170 DNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 229
Query: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICE 513
+GH ++ F + +D+ + +W + I +
Sbjct: 230 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 268
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/80 (26%), Positives = 38/80 (47%)
Query: 342 YKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCC 401
++L ++LH V+ +S P + L++ D K+L L + +L T GH +
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
Query: 402 FHPSGDKLATSSGDTTVKLW 421
F +G+ A+ D V +W
Sbjct: 241 FSRTGEYFASGGSDEQVMVW 260
Score = 33.9 bits (76), Expect = 0.47
Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 1/65 (1%)
Query: 568 VNFDSSGRVLAQASGNGVIHL-LDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGT 626
VNF SG +LA S + + + + GE H +V F DG+ + D T
Sbjct: 29 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 88
Query: 627 VRTWS 631
V+ W+
Sbjct: 89 VKVWA 93
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 120 bits (300), Expect = 5e-27
Identities = 72/260 (27%), Positives = 123/260 (47%), Gaps = 21/260 (8%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
GH ++ FHP + ++S D T+K+WD GD T +GH+ +V ++ G +
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165
Query: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
AS S D T K+WD C T++GH +V+S+ P + ++++S DKT+ +W+ +TG
Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY 225
Query: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLW---------DFRKLLPIVSI---- 558
C ++ GH + + G +IASC ++W + R+ +V
Sbjct: 226 CVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWA 285
Query: 559 ------DIGPSPGNEVNFDSS-GRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVV 610
I + G+E G L S + I + D+ +G + L+GH+N V+
Sbjct: 286 PESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVL 345
Query: 611 FSHDGEILFSGGSDGTVRTW 630
F G+ + S D T+R W
Sbjct: 346 FHSGGKFILSCADDKTLRVW 365
Score = 108 bits (271), Expect = 1e-23
Identities = 63/220 (28%), Positives = 99/220 (45%), Gaps = 20/220 (9%)
Query: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
H V +S +L SC D K+ + T GH +S P+GD +
Sbjct: 149 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIV 208
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
++S D T+K+W++ G C+ TF GH V + G +AS S D+T ++W V ++ C
Sbjct: 209 SASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKEC 268
Query: 471 RCTLYGHTDSVNSIEFFPFSN--------------------TLLTSSADKTLSIWDARTG 510
+ L H V I + P S+ LL+ S DKT+ +WD TG
Sbjct: 269 KAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG 328
Query: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR 550
+C +L GH + + +F G I SC ++WD++
Sbjct: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368
Score = 95.5 bits (236), Expect = 1e-19
Identities = 58/220 (26%), Positives = 95/220 (43%), Gaps = 20/220 (9%)
Query: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
H+ VS V++ P+ D +VS D+ K+ + + T GH +W+ + G +A
Sbjct: 191 HDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWH--------------------SCGNF 450
+ S D TV++W + +C H V +W G F
Sbjct: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310
Query: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
+ S S DKT K+WDV++ C TL GH + V + F +L+ + DKTL +WD +
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
Query: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR 550
C ++L H H + F + + K+W+ R
Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 84.7 bits (208), Expect = 2e-16
Identities = 49/158 (31%), Positives = 79/158 (50%), Gaps = 1/158 (0%)
Query: 474 LYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGH 533
L GH V + F P + ++++S D T+ +WD TG E++L GH S+ D FD G
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 534 MIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKS 593
++ASC A KLWDF+ I ++ + V +G + AS + I + ++++
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223
Query: 594 GE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
G + GH V + DG ++ S +D TVR W
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 50.8 bits (120), Expect = 4e-06
Identities = 30/117 (25%), Positives = 54/117 (46%), Gaps = 1/117 (0%)
Query: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSG 574
+L GH + IF P ++ S K+WD+ ++ +++FD SG
Sbjct: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162
Query: 575 RVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
++LA S + I L D + E I + GH++ +V +G+ + S D T++ W
Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 119 bits (299), Expect = 6e-27
Identities = 86/296 (29%), Positives = 135/296 (45%), Gaps = 5/296 (1%)
Query: 337 PAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDW 396
PA + F H V+ + P +L++ ED +L GHT
Sbjct: 6 PATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGP 65
Query: 397 LSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSL 456
+ C F P G A++S D TV+LWD+ + C+ +GH R+V + ++ +AS
Sbjct: 66 VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGW 125
Query: 457 DKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDAR---TGICE 513
DK +WDV S + L GH DS+ S +F P N L T S D T+ IWD R +
Sbjct: 126 DKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSH 185
Query: 514 QSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSS 573
Q+L GH +I+ + G ++AS +W ++ + + + F
Sbjct: 186 QALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
Query: 574 GRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVR 628
LA A + ++ + D +G+ + L G + AHT F+ DG+IL SG +D T R
Sbjct: 245 ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 109 bits (272), Expect = 9e-24
Identities = 73/241 (30%), Positives = 107/241 (44%), Gaps = 3/241 (1%)
Query: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA 452
H ++ F P G L T S D V W+ G + GH+ V C + G+ A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512
S+S D T ++WDV +C L GH SV ++ F P S L + DK + +WD ++G
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 513 EQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDI--GPSPGNEVNF 570
+ L GH SI + F P + +A+ +WD R + P VS G S
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
Query: 571 DSSGRVLAQASGNGVIHL-LDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRT 629
S+ +LA S + IH+ S + +L GH ++ FS D L S G V+
Sbjct: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
Query: 630 W 630
W
Sbjct: 260 W 260
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 115 bits (289), Expect = 9e-26
Identities = 72/253 (28%), Positives = 116/253 (45%), Gaps = 15/253 (5%)
Query: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA 452
HTD + CF G ++A+ D T++++ G+ +L + H V C + + F+A
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLL--TSSADKTLSIWDARTG 510
+ S+DK KIW+ + T H++ VN F S+ LL T S+D L +WD
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
Query: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDI--------GP 562
C +++GH +S+N F P ++ASC A G KLWD SI++ P
Sbjct: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
Query: 563 SPGNEV-----NFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEI 617
EV ++ + G + A+ N + ++ GH + H V+FS DG
Sbjct: 794 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 853
Query: 618 LFSGGSDGTVRTW 630
+ D T+R W
Sbjct: 854 FLTSSDDQTIRLW 866
Score = 73.9 bits (180), Expect = 4e-13
Identities = 71/312 (22%), Positives = 124/312 (39%), Gaps = 36/312 (11%)
Query: 343 KLKNIFRLHELPVSCVSM--QPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDC 400
+L + + H V+C H +L + D K+ L + T FGHT+ ++ C
Sbjct: 690 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC 749
Query: 401 CFHPSGDKLATSSGDTTVKLWDLCKGD---------CILTFEGHSR----AVWSCTWHSC 447
F P LA+ S D T+KLWD + L E V C+W +
Sbjct: 750 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 809
Query: 448 GNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDA 507
G + ++ +K +W+ +S GH V+ + F P ++ LTSS D+T+ +W+
Sbjct: 810 GARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 868
Query: 508 RTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC-------GVTKLWDFRKLLPIVSIDI 560
+ +C+ S + D +F M+ + D G T D+ + +
Sbjct: 869 KK-VCKNSAVMLKQEV-DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCL 926
Query: 561 GPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILF 619
P + +A NG I +L+L + I H+ + F+ D + L
Sbjct: 927 SPHL----------QYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLI 976
Query: 620 SGGSDGTVRTWS 631
S D ++ W+
Sbjct: 977 SSSDDAEIQVWN 988
Score = 72.4 bits (176), Expect = 1e-12
Identities = 64/290 (22%), Positives = 117/290 (40%), Gaps = 18/290 (6%)
Query: 356 SCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSD-----CCFHPSGDKLA 410
S V ++ D++ E + V + + ++ G D+L++ CC P +A
Sbjct: 875 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 934
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
+ +++ +L + H + VW + + + SSS D ++W+ ++C
Sbjct: 935 FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC 994
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
L GH ++V S LL+ S D T+ +W+ TG E+ H ++
Sbjct: 995 -IFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH 1052
Query: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLD 590
+S A K+W F LLP+ + F +LA NG I + +
Sbjct: 1053 DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1112
Query: 591 LKSGEIHKLMG---------HENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
+ +GE+ L H + FS DG++L S G G ++ W+
Sbjct: 1113 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWN 1160
Score = 59.7 bits (143), Expect = 8e-09
Identities = 60/247 (24%), Positives = 86/247 (34%), Gaps = 50/247 (20%)
Query: 350 LHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHT--------------- 394
L E VSC + PH + E+ ++L L + + F H
Sbjct: 916 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 975
Query: 395 ------------DWLSDCCFHPSG-------------DKLATSSGDTTVKLWDLCKGDCI 429
+W D C G +L + S D TVK+W++ G+
Sbjct: 976 ISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKE 1035
Query: 430 LTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPF 489
F H V SC +S+S DKT+KIW + L GH V F
Sbjct: 1036 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1095
Query: 490 SNTLLTSSADKTLSIWDARTG--------ICEQSLYGHMHSINDAIFDPRGHMIASCDAC 541
S L T + + IW+ G + E+ H + D F P G M+ S A
Sbjct: 1096 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AG 1153
Query: 542 GVTKLWD 548
G K W+
Sbjct: 1154 GYIKWWN 1160
Score = 59.3 bits (142), Expect = 1e-08
Identities = 45/163 (27%), Positives = 69/163 (42%), Gaps = 3/163 (1%)
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
R + HTD+V F + + ADKTL ++ A TG + H + F
Sbjct: 608 RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST 667
Query: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGR--VLAQASGNGVIHL 588
IA+C K+W+ + + D N +F +S +LA S + + L
Sbjct: 668 DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 727
Query: 589 LDLKSGEIHKLM-GHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
DL E M GH N + FS D ++L S +DGT++ W
Sbjct: 728 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 115 bits (289), Expect = 9e-26
Identities = 72/253 (28%), Positives = 116/253 (45%), Gaps = 15/253 (5%)
Query: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA 452
HTD + CF G ++A+ D T++++ G+ +L + H V C + + F+A
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLL--TSSADKTLSIWDARTG 510
+ S+DK KIW+ + T H++ VN F S+ LL T S+D L +WD
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
Query: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDI--------GP 562
C +++GH +S+N F P ++ASC A G KLWD SI++ P
Sbjct: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
Query: 563 SPGNEV-----NFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEI 617
EV ++ + G + A+ N + ++ GH + H V+FS DG
Sbjct: 783 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 842
Query: 618 LFSGGSDGTVRTW 630
+ D T+R W
Sbjct: 843 FLTSSDDQTIRLW 855
Score = 73.9 bits (180), Expect = 4e-13
Identities = 71/312 (22%), Positives = 124/312 (39%), Gaps = 36/312 (11%)
Query: 343 KLKNIFRLHELPVSCVSM--QPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDC 400
+L + + H V+C H +L + D K+ L + T FGHT+ ++ C
Sbjct: 679 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC 738
Query: 401 CFHPSGDKLATSSGDTTVKLWDLCKGD---------CILTFEGHSR----AVWSCTWHSC 447
F P LA+ S D T+KLWD + L E V C+W +
Sbjct: 739 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 798
Query: 448 GNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDA 507
G + ++ +K +W+ +S GH V+ + F P ++ LTSS D+T+ +W+
Sbjct: 799 GARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 857
Query: 508 RTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC-------GVTKLWDFRKLLPIVSIDI 560
+ +C+ S + D +F M+ + D G T D+ + +
Sbjct: 858 KK-VCKNSAVMLKQEV-DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCL 915
Query: 561 GPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILF 619
P + +A NG I +L+L + I H+ + F+ D + L
Sbjct: 916 SPHL----------QYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLI 965
Query: 620 SGGSDGTVRTWS 631
S D ++ W+
Sbjct: 966 SSSDDAEIQVWN 977
Score = 72.4 bits (176), Expect = 1e-12
Identities = 64/290 (22%), Positives = 117/290 (40%), Gaps = 18/290 (6%)
Query: 356 SCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSD-----CCFHPSGDKLA 410
S V ++ D++ E + V + + ++ G D+L++ CC P +A
Sbjct: 864 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 923
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
+ +++ +L + H + VW + + + SSS D ++W+ ++C
Sbjct: 924 FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC 983
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
L GH ++V S LL+ S D T+ +W+ TG E+ H ++
Sbjct: 984 -IFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH 1041
Query: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLD 590
+S A K+W F LLP+ + F +LA NG I + +
Sbjct: 1042 DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1101
Query: 591 LKSGEIHKLMG---------HENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
+ +GE+ L H + FS DG++L S G G ++ W+
Sbjct: 1102 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWN 1149
Score = 59.7 bits (143), Expect = 8e-09
Identities = 60/247 (24%), Positives = 86/247 (34%), Gaps = 50/247 (20%)
Query: 350 LHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHT--------------- 394
L E VSC + PH + E+ ++L L + + F H
Sbjct: 905 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 964
Query: 395 ------------DWLSDCCFHPSG-------------DKLATSSGDTTVKLWDLCKGDCI 429
+W D C G +L + S D TVK+W++ G+
Sbjct: 965 ISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKE 1024
Query: 430 LTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPF 489
F H V SC +S+S DKT+KIW + L GH V F
Sbjct: 1025 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1084
Query: 490 SNTLLTSSADKTLSIWDARTG--------ICEQSLYGHMHSINDAIFDPRGHMIASCDAC 541
S L T + + IW+ G + E+ H + D F P G M+ S A
Sbjct: 1085 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AG 1142
Query: 542 GVTKLWD 548
G K W+
Sbjct: 1143 GYIKWWN 1149
Score = 59.3 bits (142), Expect = 1e-08
Identities = 45/163 (27%), Positives = 69/163 (42%), Gaps = 3/163 (1%)
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
R + HTD+V F + + ADKTL ++ A TG + H + F
Sbjct: 597 RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST 656
Query: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGR--VLAQASGNGVIHL 588
IA+C K+W+ + + D N +F +S +LA S + + L
Sbjct: 657 DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 716
Query: 589 LDLKSGEIHKLM-GHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
DL E M GH N + FS D ++L S +DGT++ W
Sbjct: 717 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 115 bits (288), Expect = 1e-25
Identities = 77/287 (26%), Positives = 122/287 (42%), Gaps = 10/287 (3%)
Query: 354 PVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD------ 407
P+S P+ +L + L K+ +P CN+L T GH + FHP
Sbjct: 233 PISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPK 292
Query: 408 --KLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDV 465
LA+ + D +VKLW L + + EGH+ V WH G F+ ++ D++ ++WD+
Sbjct: 293 DVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
Query: 466 NSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSIND 525
++ GH+ V I F + T D +WD RTG C L GH+ I
Sbjct: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 412
Query: 526 AIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD--SSGRVLAQASGN 583
F P G+ IA+ K+WD R+ + +I + V F+ +L A N
Sbjct: 413 INFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDN 472
Query: 584 GVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
+ L GHE + + S DG+++ + D T + W
Sbjct: 473 TAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 101 bits (251), Expect = 2e-21
Identities = 60/198 (30%), Positives = 89/198 (44%), Gaps = 1/198 (0%)
Query: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
H + V+ V P L + DR W++ L +L GH+ + D FH G
Sbjct: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAG 381
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
T D ++WDL G CI+ EGH + ++ + G +A+ S D T K+WD+ RC
Sbjct: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441
Query: 471 RCTLYGHTDSVNSIEFFPF-SNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFD 529
T+ H + V ++F P N LLT + D T IW ++L GH +
Sbjct: 442 VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDIS 501
Query: 530 PRGHMIASCDACGVTKLW 547
G +IA+C KLW
Sbjct: 502 SDGQLIATCSYDRTFKLW 519
Score = 57.4 bits (137), Expect = 4e-08
Identities = 48/207 (23%), Positives = 84/207 (40%), Gaps = 11/207 (5%)
Query: 434 GHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSN-- 491
G R + C + +A++ K+W V TL GH +V +I F P S
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
Query: 492 ------TLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTK 545
L + +AD ++ +W + + GH + ++ P G + + +
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
Query: 546 LWDFRKLLPIVSIDIGPSPG-NEVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHE 603
LWD I+ + G S G ++ F G + + + DL++G I L GH
Sbjct: 349 LWDLEAQEEILHQE-GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHL 407
Query: 604 NEAHTVVFSHDGEILFSGGSDGTVRTW 630
E + + FS +G + +G D T + W
Sbjct: 408 KEIYGINFSPNGYHIATGSGDNTCKVW 434
Score = 55.8 bits (133), Expect = 1e-07
Identities = 44/168 (26%), Positives = 65/168 (38%), Gaps = 9/168 (5%)
Query: 472 CTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIF--- 528
C+ G ++ F P S L T+ +W +L GH ++ +F
Sbjct: 225 CSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPK 284
Query: 529 -----DPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGN 583
DP+ +ASC A G KLW P+ I+ V + SGR L +
Sbjct: 285 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYD 344
Query: 584 GVIHLLDLKS-GEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
L DL++ EI GH + + F DG + +GG D R W
Sbjct: 345 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 392
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 110 bits (275), Expect = 4e-24
Identities = 71/240 (29%), Positives = 116/240 (48%), Gaps = 12/240 (5%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
GH D + C G+++ + S D T+K+W G C+ T GH+ VWS N +
Sbjct: 260 GHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD--NII 316
Query: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
S S D+T K+W+ + C TLYGHT +V + +++ S D TL +WD TG
Sbjct: 317 ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQ 374
Query: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
C L GH+ ++ +D R + + D + K+WD + ++ + + FD
Sbjct: 375 CLHVLMGHVAAVRCVQYDGRRVVSGAYDF--MVKVWDPETETCLHTLQGHTNRVYSLQFD 432
Query: 572 SSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
G + S + I + D+++G IH L GH++ + + IL SG +D TV+ W
Sbjct: 433 --GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIW 488
Score = 101 bits (252), Expect = 2e-21
Identities = 76/271 (28%), Positives = 124/271 (45%), Gaps = 26/271 (9%)
Query: 359 SMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTV 418
S Q +I++S DR KV + T +GHT + C H ++ + S D T+
Sbjct: 308 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATL 365
Query: 419 KLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHT 478
++WD+ G C+ GH AV C + G V S + D K+WD +E C TL GHT
Sbjct: 366 RVWDIETGQCLHVLMGHVAAV-RCVQYD-GRRVVSGAYDFMVKVWDPETETCLHTLQGHT 423
Query: 479 DSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASC 538
+ V S++F +++ S D ++ +WD TG C +L GH + + + +++ S
Sbjct: 424 NRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG--MELKDNILVSG 479
Query: 539 DACGVTKLWDFRKLLPIVSIDIGPSPGNEVN--FDSSGRVLAQASGNGVIHLLDLKSGEI 596
+A K+WD + + ++ GP+ + + +S +G + L DLK+GE
Sbjct: 480 NADSTVKIWDIKTGQCLQTLQ-GPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE- 537
Query: 597 HKLMGHENEAHTVVFSHDGEILFSGGSDGTV 627
F + L SGGS G V
Sbjct: 538 --------------FIRNLVTLESGGSGGVV 554
Score = 92.4 bits (228), Expect = 1e-18
Identities = 71/239 (29%), Positives = 113/239 (47%), Gaps = 16/239 (6%)
Query: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
H V C+ + H+ +VS D +V + L GH + C G ++
Sbjct: 342 HTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR--CVQYDGRRVV 397
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
+ + D VK+WD C+ T +GH+ V+S + G V S SLD + ++WDV + C
Sbjct: 398 SGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNC 455
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYG---HMHSINDAI 527
TL GH + +E N L++ +AD T+ IWD +TG C Q+L G H ++
Sbjct: 456 IHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQ 513
Query: 528 FDPRGHMIASCDACGVTKLWDFRK---LLPIVSIDIGPSPGNEVNFDSSGRVLAQASGN 583
F+ + +I S D G KLWD + + +V+++ G S G +S L A G+
Sbjct: 514 FN-KNFVITSSDD-GTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGS 570
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 110 bits (275), Expect = 4e-24
Identities = 71/240 (29%), Positives = 116/240 (48%), Gaps = 12/240 (5%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
GH D + C G+++ + S D T+K+W G C+ T GH+ VWS N +
Sbjct: 378 GHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD--NII 434
Query: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
S S D+T K+W+ + C TLYGHT +V + +++ S D TL +WD TG
Sbjct: 435 ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQ 492
Query: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
C L GH+ ++ +D R + + D + K+WD + ++ + + FD
Sbjct: 493 CLHVLMGHVAAVRCVQYDGRRVVSGAYDF--MVKVWDPETETCLHTLQGHTNRVYSLQFD 550
Query: 572 SSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
G + S + I + D+++G IH L GH++ + + IL SG +D TV+ W
Sbjct: 551 --GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIW 606
Score = 101 bits (252), Expect = 2e-21
Identities = 76/271 (28%), Positives = 124/271 (45%), Gaps = 26/271 (9%)
Query: 359 SMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTV 418
S Q +I++S DR KV + T +GHT + C H ++ + S D T+
Sbjct: 426 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATL 483
Query: 419 KLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHT 478
++WD+ G C+ GH AV C + G V S + D K+WD +E C TL GHT
Sbjct: 484 RVWDIETGQCLHVLMGHVAAV-RCVQYD-GRRVVSGAYDFMVKVWDPETETCLHTLQGHT 541
Query: 479 DSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASC 538
+ V S++F +++ S D ++ +WD TG C +L GH + + + +++ S
Sbjct: 542 NRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG--MELKDNILVSG 597
Query: 539 DACGVTKLWDFRKLLPIVSIDIGPSPGNEVN--FDSSGRVLAQASGNGVIHLLDLKSGEI 596
+A K+WD + + ++ GP+ + + +S +G + L DLK+GE
Sbjct: 598 NADSTVKIWDIKTGQCLQTLQ-GPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE- 655
Query: 597 HKLMGHENEAHTVVFSHDGEILFSGGSDGTV 627
F + L SGGS G V
Sbjct: 656 --------------FIRNLVTLESGGSGGVV 672
Score = 92.4 bits (228), Expect = 1e-18
Identities = 71/239 (29%), Positives = 113/239 (47%), Gaps = 16/239 (6%)
Query: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
H V C+ + H+ +VS D +V + L GH + C G ++
Sbjct: 460 HTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR--CVQYDGRRVV 515
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
+ + D VK+WD C+ T +GH+ V+S + G V S SLD + ++WDV + C
Sbjct: 516 SGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNC 573
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYG---HMHSINDAI 527
TL GH + +E N L++ +AD T+ IWD +TG C Q+L G H ++
Sbjct: 574 IHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQ 631
Query: 528 FDPRGHMIASCDACGVTKLWDFRK---LLPIVSIDIGPSPGNEVNFDSSGRVLAQASGN 583
F+ + +I S D G KLWD + + +V+++ G S G +S L A G+
Sbjct: 632 FN-KNFVITSSDD-GTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGS 688
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 110 bits (275), Expect = 4e-24
Identities = 71/240 (29%), Positives = 116/240 (48%), Gaps = 12/240 (5%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
GH D + C G+++ + S D T+K+W G C+ T GH+ VWS N +
Sbjct: 298 GHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD--NII 354
Query: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
S S D+T K+W+ + C TLYGHT +V + +++ S D TL +WD TG
Sbjct: 355 ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQ 412
Query: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
C L GH+ ++ +D R + + D + K+WD + ++ + + FD
Sbjct: 413 CLHVLMGHVAAVRCVQYDGRRVVSGAYDF--MVKVWDPETETCLHTLQGHTNRVYSLQFD 470
Query: 572 SSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
G + S + I + D+++G IH L GH++ + + IL SG +D TV+ W
Sbjct: 471 --GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIW 526
Score = 101 bits (252), Expect = 2e-21
Identities = 76/271 (28%), Positives = 124/271 (45%), Gaps = 26/271 (9%)
Query: 359 SMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTV 418
S Q +I++S DR KV + T +GHT + C H ++ + S D T+
Sbjct: 346 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATL 403
Query: 419 KLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHT 478
++WD+ G C+ GH AV C + G V S + D K+WD +E C TL GHT
Sbjct: 404 RVWDIETGQCLHVLMGHVAAV-RCVQYD-GRRVVSGAYDFMVKVWDPETETCLHTLQGHT 461
Query: 479 DSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASC 538
+ V S++F +++ S D ++ +WD TG C +L GH + + + +++ S
Sbjct: 462 NRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG--MELKDNILVSG 517
Query: 539 DACGVTKLWDFRKLLPIVSIDIGPSPGNEVN--FDSSGRVLAQASGNGVIHLLDLKSGEI 596
+A K+WD + + ++ GP+ + + +S +G + L DLK+GE
Sbjct: 518 NADSTVKIWDIKTGQCLQTLQ-GPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE- 575
Query: 597 HKLMGHENEAHTVVFSHDGEILFSGGSDGTV 627
F + L SGGS G V
Sbjct: 576 --------------FIRNLVTLESGGSGGVV 592
Score = 92.4 bits (228), Expect = 1e-18
Identities = 71/239 (29%), Positives = 113/239 (47%), Gaps = 16/239 (6%)
Query: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
H V C+ + H+ +VS D +V + L GH + C G ++
Sbjct: 380 HTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR--CVQYDGRRVV 435
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
+ + D VK+WD C+ T +GH+ V+S + G V S SLD + ++WDV + C
Sbjct: 436 SGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNC 493
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYG---HMHSINDAI 527
TL GH + +E N L++ +AD T+ IWD +TG C Q+L G H ++
Sbjct: 494 IHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQ 551
Query: 528 FDPRGHMIASCDACGVTKLWDFRK---LLPIVSIDIGPSPGNEVNFDSSGRVLAQASGN 583
F+ + +I S D G KLWD + + +V+++ G S G +S L A G+
Sbjct: 552 FN-KNFVITSSDD-GTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGS 608
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 108 bits (271), Expect = 1e-23
Identities = 60/212 (28%), Positives = 103/212 (48%), Gaps = 1/212 (0%)
Query: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
H PV V + ++++V+ + +V L +L T GH + FHP G+ +A
Sbjct: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
+ S DT +KLWD+ + C+ + GHS+AV + G ++AS++ D T K+WD+ + +
Sbjct: 122 SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKM 181
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
GHT VN +EF P L + S+D+T+ WD + G + +F+P
Sbjct: 182 MSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241
Query: 531 RGHMIAS-CDACGVTKLWDFRKLLPIVSIDIG 561
G + S C W+ + +V ++ G
Sbjct: 242 DGCCLYSGCQDSLRVYGWEPERCFDVVLVNWG 273
Score = 104 bits (260), Expect = 2e-22
Identities = 62/221 (28%), Positives = 101/221 (45%), Gaps = 1/221 (0%)
Query: 405 SGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWD 464
SG LAT D V LW + K +CI++ GH+ V S ++ + + S + ++WD
Sbjct: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Query: 465 VNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSIN 524
+ + + TL GH ++ S++F P+ + + S D + +WD R C GH ++
Sbjct: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
Query: 525 DAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNG 584
F P G +AS KLWD + P N V F + +LA S +
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211
Query: 585 VIHLLDLKSGEIHKLM-GHENEAHTVVFSHDGEILFSGGSD 624
I DL+ ++ + G +V+F+ DG L+SG D
Sbjct: 212 TIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Score = 102 bits (255), Expect = 8e-22
Identities = 66/240 (27%), Positives = 105/240 (43%), Gaps = 8/240 (3%)
Query: 339 KFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGED----RLWKVLGLPKCNVLLTGFGHT 394
K +KL+ I H VS + + L++ G D LW + P C + LTG HT
Sbjct: 8 KTAWKLQEIVA-HASNVSSLVLGKASGRLLATGGDDCRVNLWSI-NKPNCIMSLTG--HT 63
Query: 395 DWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASS 454
+ + + + S ++++WDL + T GH + S +H G FVAS
Sbjct: 64 SPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASG 123
Query: 455 SLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQ 514
S D K+WD+ + C GH+ +V + F P L +++ D T+ +WD G
Sbjct: 124 SQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS 183
Query: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSG 574
GH +N F P +++AS + + WD K + I+ P P V F+ G
Sbjct: 184 EFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDG 243
Score = 81.3 bits (199), Expect = 3e-15
Identities = 50/184 (27%), Positives = 80/184 (43%), Gaps = 1/184 (0%)
Query: 448 GNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDA 507
G +A+ D +W +N C +L GHT V S+ ++ S ++ +WD
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 508 RTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNE 567
++L GH +I F P G +AS KLWD R+ +
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 568 VNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILFSGGSDGT 626
+ F G+ LA A+ + + L DL +G++ + GH + V F + +L SG SD T
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
Query: 627 VRTW 630
+R W
Sbjct: 213 IRFW 216
Score = 52.4 bits (124), Expect = 1e-06
Identities = 37/159 (23%), Positives = 66/159 (41%), Gaps = 2/159 (1%)
Query: 474 LYGHTDSVNSIEFFPFSNTLLTSSADKT-LSIWDARTGICEQSLYGHMHSINDAIFDPRG 532
+ H +V+S+ S LL + D +++W C SL GH + +
Sbjct: 16 IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE 75
Query: 533 HMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLK 592
+I + G ++WD + ++ + ++F G +A S + I L D++
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
Query: 593 -SGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
G + + GH + FS DG+ L S D TV+ W
Sbjct: 136 RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 174
Score = 50.8 bits (120), Expect = 4e-06
Identities = 35/123 (28%), Positives = 55/123 (44%), Gaps = 1/123 (0%)
Query: 348 FRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD 407
+R H V C+ P L S +D K+ L ++ GHT ++ FHP+
Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEY 202
Query: 408 KLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNS 467
LA+ S D T++ WDL K + EG V S ++ G + S D + +++
Sbjct: 203 LLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEP 261
Query: 468 ERC 470
ERC
Sbjct: 262 ERC 264
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 108 bits (269), Expect = 2e-23
Identities = 65/240 (27%), Positives = 106/240 (44%), Gaps = 7/240 (2%)
Query: 372 EDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILT 431
+D L +++ + L +GH+ + F P + L +SS D TV+LW L C++
Sbjct: 521 DDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG 580
Query: 432 FEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSN 491
++GH+ VW + G + S D+ +++W + + GH VN F P SN
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
Query: 492 TLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
+ T SAD+T+ +WD G C + GH I+ F P G +A+ G LWD
Sbjct: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
Query: 552 LLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLL-------DLKSGEIHKLMGHEN 604
L + + + F G +LA S + + L DL++ + GH N
Sbjct: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 760
Score = 95.9 bits (237), Expect = 1e-19
Identities = 52/160 (32%), Positives = 79/160 (49%)
Query: 348 FRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD 407
++ H PV P+ VS G DR+ ++ L GH ++ FHP+ +
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
Query: 408 KLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNS 467
+AT S D TV+LWD+ G+C+ F GH + S T+ G F+A+ + D +WD+
Sbjct: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
Query: 468 ERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDA 507
L GHTD+V S+ F L + S D T+ +WDA
Sbjct: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740
Score = 93.6 bits (231), Expect = 5e-19
Identities = 63/242 (26%), Positives = 98/242 (40%), Gaps = 4/242 (1%)
Query: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
H PV S P ++ L+S ED ++ L L+ GH + D F P G
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV 601
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
+ D +LW + F GH V +H N+VA+ S D+T ++WDV + C
Sbjct: 602 SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC 661
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
GH ++S+ F P L T + D + +WD G+ L GH ++ F
Sbjct: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR 721
Query: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLA----QASGNGVI 586
G ++AS +LWD K + D + +N + + L V+
Sbjct: 722 DGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVV 781
Query: 587 HL 588
HL
Sbjct: 782 HL 783
Score = 90.9 bits (224), Expect = 3e-18
Identities = 59/219 (26%), Positives = 97/219 (44%), Gaps = 1/219 (0%)
Query: 413 SGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRC 472
S D ++ D + GHS V+ ++ N++ SSS D T ++W + + C
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 473 TLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRG 532
GH V +F P+ ++ D+ +W + GH+ +N F P
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS 639
Query: 533 HMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLK 592
+ +A+ A +LWD + P + + F +GR LA + +G + L D+
Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 699
Query: 593 SG-EIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
G + +L GH + ++ FS DGEIL SG D TVR W
Sbjct: 700 HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 82.0 bits (201), Expect = 1e-15
Identities = 93/390 (23%), Positives = 147/390 (37%), Gaps = 54/390 (13%)
Query: 249 DKVVGQISGLQETLKKLQRGHSYHG----PQIKVDHSREKENAPEGPTQKGLREAREQNK 304
D +VG ++G E ++ + + G P+I+V E E EG ++G + ++ K
Sbjct: 353 DAMVGSLAG--EAKREANKSKVFFGLLKEPEIEVPLDDEDE---EGENEEGKPKKKKPKK 407
Query: 305 CKTKMKGNTKDSEFPIDMQ-PNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPH 363
K +D P + P P L S KL I + E
Sbjct: 408 DSIGSKSKKQDPNAPPQNRIPLPELKDSD----------KLDKIMNMKETTKR------- 450
Query: 364 KDILVSCGEDRLWKVLGLPKCNVL--LTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLW 421
V G D L + N LT TD +A D+TV++W
Sbjct: 451 ----VRLGPDCLPSICFYTFLNAYQGLTAVDVTD---------DSSLIAGGFADSTVRVW 497
Query: 422 DLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSV 481
+ + + S S + + S D +I D + LYGH+ V
Sbjct: 498 SVTP-----------KKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPV 546
Query: 482 NSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC 541
F P N LL+SS D T+ +W +T C GH + + D F P G+ S
Sbjct: 547 YGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHD 606
Query: 542 GVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLM- 600
V +LW P+ + N F + +A S + + L D+ +G ++
Sbjct: 607 RVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFT 666
Query: 601 GHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
GH+ H++ FS +G L +G +DG V W
Sbjct: 667 GHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
Score = 63.5 bits (153), Expect = 6e-10
Identities = 41/126 (32%), Positives = 60/126 (47%), Gaps = 6/126 (4%)
Query: 342 YKLKNIFRLHELPVSCVSMQPHKDILVSCGEDR---LWKVLGLPKCNVLLTGFGHTDWLS 398
Y+ IF H V+C P+ + + + DR LW VL C + TG H +
Sbjct: 617 YQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN-GNCVRIFTG--HKGPIH 673
Query: 399 DCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDK 458
F P+G LAT + D V LWD+ G + +GH+ V S + G +AS S+D
Sbjct: 674 SLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN 733
Query: 459 TSKIWD 464
T ++WD
Sbjct: 734 TVRLWD 739
Score = 34.7 bits (78), Expect = 0.27
Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 1/73 (1%)
Query: 560 IGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSG-EIHKLMGHENEAHTVVFSHDGEIL 618
+ P V S ++ + S + + ++D K+ E+ L GH + FS D L
Sbjct: 499 VTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYL 558
Query: 619 FSGGSDGTVRTWS 631
S DGTVR WS
Sbjct: 559 LSSSEDGTVRLWS 571
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 105 bits (263), Expect = 1e-22
Identities = 87/316 (27%), Positives = 131/316 (41%), Gaps = 37/316 (11%)
Query: 345 KNIFRLHELPVSCVSMQPHKDI------------LVSCGEDRLWKVLGLPKCNVLLTGFG 392
KNI L L V +PH D + SCG D+ +V LL
Sbjct: 601 KNITNLSRLVV-----RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKA 655
Query: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGN--F 450
H D + C F +AT S D VK+W+ G+ + T++ HS V C + + +
Sbjct: 656 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 715
Query: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
+A+ S D K+WD+N + CR T++GHT+SVN F P L + SAD TL +WDA +
Sbjct: 716 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 775
Query: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTK--------------LWDFRKLLPIV 556
+S+ +N + DP+ M C + L+D +
Sbjct: 776 NERKSINVKQFFLN--LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 833
Query: 557 SIDIG-PSPGNEVNFDSSGRVLAQASGNGVIHLLDLKS-GEIHKLMGHENEAHTVVFSHD 614
I G S +F + A + L + S ++ GH + H V+FS D
Sbjct: 834 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 893
Query: 615 GEILFSGGSDGTVRTW 630
G + D T+R W
Sbjct: 894 GSSFLTSSDDQTIRLW 909
Score = 72.4 bits (176), Expect = 1e-12
Identities = 64/290 (22%), Positives = 117/290 (40%), Gaps = 18/290 (6%)
Query: 356 SCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSD-----CCFHPSGDKLA 410
S V ++ D++ E + V + + ++ G D+L++ CC P +A
Sbjct: 918 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 977
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
+ +++ +L + H + VW + + + SSS D ++W+ ++C
Sbjct: 978 FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC 1037
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
L GH ++V S LL+ S D T+ +W+ TG E+ H ++
Sbjct: 1038 -IFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH 1095
Query: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLD 590
+S A K+W F LLP+ + F +LA NG I + +
Sbjct: 1096 DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155
Query: 591 LKSGEIHKLMG---------HENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
+ +GE+ L H + FS DG++L S G G ++ W+
Sbjct: 1156 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWN 1203
Score = 59.7 bits (143), Expect = 8e-09
Identities = 60/247 (24%), Positives = 86/247 (34%), Gaps = 50/247 (20%)
Query: 350 LHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHT--------------- 394
L E VSC + PH + E+ ++L L + + F H
Sbjct: 959 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 1018
Query: 395 ------------DWLSDCCFHPSG-------------DKLATSSGDTTVKLWDLCKGDCI 429
+W D C G +L + S D TVK+W++ G+
Sbjct: 1019 ISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKE 1078
Query: 430 LTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPF 489
F H V SC +S+S DKT+KIW + L GH V F
Sbjct: 1079 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1138
Query: 490 SNTLLTSSADKTLSIWDARTG--------ICEQSLYGHMHSINDAIFDPRGHMIASCDAC 541
S L T + + IW+ G + E+ H + D F P G M+ S A
Sbjct: 1139 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AG 1196
Query: 542 GVTKLWD 548
G K W+
Sbjct: 1197 GYIKWWN 1203
Score = 58.5 bits (140), Expect = 2e-08
Identities = 61/280 (21%), Positives = 104/280 (37%), Gaps = 44/280 (15%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWD---LCKGDCILTFE--------------- 433
GH W+ F P G TSS D T++LW+ +CK ++ +
Sbjct: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939
Query: 434 -GHSR------------------AVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
H R V C ++A + +I ++ + R +
Sbjct: 940 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999
Query: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHM 534
+ H +V I+F TL++SS D + +W+ + C L GH ++ D +
Sbjct: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLLKNSRL 1058
Query: 535 IASCDACGVTKLWDF---RKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL 591
+ S G K+W+ K V G +++ D++ A I DL
Sbjct: 1059 L-SWSFDGTVKVWNIITGNKEKDFVCHQ-GTVLSCDISHDATKFSSTSADKTAKIWSFDL 1116
Query: 592 KSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
+H+L GH FS D +L +G +G +R W+
Sbjct: 1117 LL-PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155
Score = 48.5 bits (114), Expect = 2e-05
Identities = 41/206 (19%), Positives = 79/206 (38%), Gaps = 20/206 (9%)
Query: 434 GHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTL 493
GH + C + + + ++W+ +S GH V+ + F P ++
Sbjct: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897
Query: 494 LTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC-------GVTKL 546
LTSS D+T+ +W+ + +C+ S + D +F M+ + D G T
Sbjct: 898 LTSSDDQTIRLWETKK-VCKNSAVMLKQEV-DVVFQENEVMVLAVDHIRRLQLINGRTGQ 955
Query: 547 WDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENE 605
D+ + + P + +A NG I +L+L + I H+
Sbjct: 956 IDYLTEAQVSCCCLSPHL----------QYIAFGDENGAIEILELVNNRIFQSRFQHKKT 1005
Query: 606 AHTVVFSHDGEILFSGGSDGTVRTWS 631
+ F+ D + L S D ++ W+
Sbjct: 1006 VWHIQFTADEKTLISSSDDAEIQVWN 1031
Score = 35.0 bits (79), Expect = 0.21
Identities = 47/240 (19%), Positives = 87/240 (36%), Gaps = 6/240 (2%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
GH + C F P + V+LW+ + GH V + G+
Sbjct: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897
Query: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
+SS D+T ++W+ + C+ + V+ + F +L + L + + RTG
Sbjct: 898 LTSSDDQTIRLWE-TKKVCKNSAVMLKQEVD-VVFQENEVMVLAVDHIRRLQLINGRTG- 954
Query: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
Q Y ++ P IA D G ++ + S + F
Sbjct: 955 --QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT 1012
Query: 572 SSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
+ + L +S + I + + + + L GH+ + +L S DGTV+ W+
Sbjct: 1013 ADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWN 1071
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 105 bits (263), Expect = 1e-22
Identities = 87/316 (27%), Positives = 131/316 (41%), Gaps = 37/316 (11%)
Query: 345 KNIFRLHELPVSCVSMQPHKDI------------LVSCGEDRLWKVLGLPKCNVLLTGFG 392
KNI L L V +PH D + SCG D+ +V LL
Sbjct: 590 KNITNLSRLVV-----RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKA 644
Query: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGN--F 450
H D + C F +AT S D VK+W+ G+ + T++ HS V C + + +
Sbjct: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 704
Query: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
+A+ S D K+WD+N + CR T++GHT+SVN F P L + SAD TL +WDA +
Sbjct: 705 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
Query: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTK--------------LWDFRKLLPIV 556
+S+ +N + DP+ M C + L+D +
Sbjct: 765 NERKSINVKQFFLN--LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 822
Query: 557 SIDIG-PSPGNEVNFDSSGRVLAQASGNGVIHLLDLKS-GEIHKLMGHENEAHTVVFSHD 614
I G S +F + A + L + S ++ GH + H V+FS D
Sbjct: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 882
Query: 615 GEILFSGGSDGTVRTW 630
G + D T+R W
Sbjct: 883 GSSFLTSSDDQTIRLW 898
Score = 72.4 bits (176), Expect = 1e-12
Identities = 64/290 (22%), Positives = 117/290 (40%), Gaps = 18/290 (6%)
Query: 356 SCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSD-----CCFHPSGDKLA 410
S V ++ D++ E + V + + ++ G D+L++ CC P +A
Sbjct: 907 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 966
Query: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
+ +++ +L + H + VW + + + SSS D ++W+ ++C
Sbjct: 967 FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC 1026
Query: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
L GH ++V S LL+ S D T+ +W+ TG E+ H ++
Sbjct: 1027 -IFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH 1084
Query: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLD 590
+S A K+W F LLP+ + F +LA NG I + +
Sbjct: 1085 DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
Query: 591 LKSGEIHKLMG---------HENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
+ +GE+ L H + FS DG++L S G G ++ W+
Sbjct: 1145 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWN 1192
Score = 59.7 bits (143), Expect = 8e-09
Identities = 60/247 (24%), Positives = 86/247 (34%), Gaps = 50/247 (20%)
Query: 350 LHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHT--------------- 394
L E VSC + PH + E+ ++L L + + F H
Sbjct: 948 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 1007
Query: 395 ------------DWLSDCCFHPSG-------------DKLATSSGDTTVKLWDLCKGDCI 429
+W D C G +L + S D TVK+W++ G+
Sbjct: 1008 ISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKE 1067
Query: 430 LTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPF 489
F H V SC +S+S DKT+KIW + L GH V F
Sbjct: 1068 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1127
Query: 490 SNTLLTSSADKTLSIWDARTG--------ICEQSLYGHMHSINDAIFDPRGHMIASCDAC 541
S L T + + IW+ G + E+ H + D F P G M+ S A
Sbjct: 1128 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AG 1185
Query: 542 GVTKLWD 548
G K W+
Sbjct: 1186 GYIKWWN 1192
Score = 58.5 bits (140), Expect = 2e-08
Identities = 61/280 (21%), Positives = 104/280 (37%), Gaps = 44/280 (15%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWD---LCKGDCILTFE--------------- 433
GH W+ F P G TSS D T++LW+ +CK ++ +
Sbjct: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
Query: 434 -GHSR------------------AVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
H R V C ++A + +I ++ + R +
Sbjct: 929 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
Query: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHM 534
+ H +V I+F TL++SS D + +W+ + C L GH ++ D +
Sbjct: 989 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLLKNSRL 1047
Query: 535 IASCDACGVTKLWDF---RKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL 591
+ S G K+W+ K V G +++ D++ A I DL
Sbjct: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQ-GTVLSCDISHDATKFSSTSADKTAKIWSFDL 1105
Query: 592 KSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
+H+L GH FS D +L +G +G +R W+
Sbjct: 1106 LL-PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
Score = 48.5 bits (114), Expect = 2e-05
Identities = 41/206 (19%), Positives = 79/206 (38%), Gaps = 20/206 (9%)
Query: 434 GHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTL 493
GH + C + + + ++W+ +S GH V+ + F P ++
Sbjct: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
Query: 494 LTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC-------GVTKL 546
LTSS D+T+ +W+ + +C+ S + D +F M+ + D G T
Sbjct: 887 LTSSDDQTIRLWETKK-VCKNSAVMLKQEV-DVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
Query: 547 WDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENE 605
D+ + + P + +A NG I +L+L + I H+
Sbjct: 945 IDYLTEAQVSCCCLSPHL----------QYIAFGDENGAIEILELVNNRIFQSRFQHKKT 994
Query: 606 AHTVVFSHDGEILFSGGSDGTVRTWS 631
+ F+ D + L S D ++ W+
Sbjct: 995 VWHIQFTADEKTLISSSDDAEIQVWN 1020
Score = 35.0 bits (79), Expect = 0.21
Identities = 47/240 (19%), Positives = 87/240 (36%), Gaps = 6/240 (2%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
GH + C F P + V+LW+ + GH V + G+
Sbjct: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
Query: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
+SS D+T ++W+ + C+ + V+ + F +L + L + + RTG
Sbjct: 887 LTSSDDQTIRLWE-TKKVCKNSAVMLKQEVD-VVFQENEVMVLAVDHIRRLQLINGRTG- 943
Query: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
Q Y ++ P IA D G ++ + S + F
Sbjct: 944 --QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT 1001
Query: 572 SSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
+ + L +S + I + + + + L GH+ + +L S DGTV+ W+
Sbjct: 1002 ADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWN 1060
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 102 bits (255), Expect = 8e-22
Identities = 79/288 (27%), Positives = 124/288 (43%), Gaps = 18/288 (6%)
Query: 351 HELPVSCVSMQPHKDILVSCGEDRL---WKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD 407
HE V C P+ L S G DRL W V G C+ T GH+ + + ++ G
Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG--DCDNYATLKGHSGAVMELHYNTDGS 122
Query: 408 KLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCG-NFVASSSLDKTSKIWDVN 466
L ++S D TV +WD G+ + +GH+ V SC G V + S D T K+WD+
Sbjct: 123 MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIR 182
Query: 467 SERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDA 526
+ T + +T V ++ F S+ +++ D + +WD R ++ GH S+
Sbjct: 183 KKAAIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGL 241
Query: 527 IFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSS---------GRVL 577
G + S ++WD R P + GN NF+ + G +
Sbjct: 242 SLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC-VKIFQGNVHNFEKNLLRCSWSPDGSKI 300
Query: 578 AQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILFSGGSD 624
A S + +++ D S I +KL GH + V F D I+ S SD
Sbjct: 301 AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
Score = 89.7 bits (221), Expect = 7e-18
Identities = 57/205 (27%), Positives = 98/205 (47%), Gaps = 4/205 (1%)
Query: 429 ILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCR-CTLYGHTDSVNSIEFF 487
I+ GH V+ C +H G+ +AS+ D+ +W+V + TL GH+ +V + +
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYN 118
Query: 488 PFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRG-HMIASCDACGVTKL 546
+ L ++S DKT+++WD+ TG + L GH +N RG ++ + G KL
Sbjct: 119 TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKL 178
Query: 547 WDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENE 605
WD RK I + D+S ++++ N I + DL+ ++ + + GH +
Sbjct: 179 WDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDND-IKVWDLRQNKLTYTMRGHADS 237
Query: 606 AHTVVFSHDGEILFSGGSDGTVRTW 630
+ S +G L S D TVR W
Sbjct: 238 VTGLSLSSEGSYLLSNAMDNTVRVW 262
Score = 84.0 bits (206), Expect = 4e-16
Identities = 55/210 (26%), Positives = 99/210 (47%), Gaps = 10/210 (4%)
Query: 392 GHTDWLSDCCFHPSGDKLA-TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNF 450
GHT +++ C G +L T S D TVKLWD+ K I TF+ ++ V + T++ +
Sbjct: 149 GHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQ 207
Query: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
+ S +D K+WD+ + T+ GH DSV + + LL+++ D T+ +WD R
Sbjct: 208 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF 267
Query: 511 I----CEQSLYGHMHSINDAI----FDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGP 562
C + G++H+ + + P G IA+ A +WD + +
Sbjct: 268 APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHA 327
Query: 563 SPGNEVNFDSSGRVLAQASGNGVIHLLDLK 592
NEV F ++ AS + +++ +++
Sbjct: 328 GSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
Score = 74.7 bits (182), Expect = 2e-13
Identities = 45/156 (28%), Positives = 76/156 (48%), Gaps = 8/156 (5%)
Query: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
V V+ D ++S G D KV L + + T GH D ++ G L +++
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
Query: 415 DTTVKLWDLC----KGDCILTFEGH----SRAVWSCTWHSCGNFVASSSLDKTSKIWDVN 466
D TV++WD+ K C+ F+G+ + + C+W G+ +A+ S D+ +WD
Sbjct: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 315
Query: 467 SERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTL 502
S R L GH S+N + F P ++++S+DK L
Sbjct: 316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 102 bits (253), Expect = 1e-21
Identities = 73/241 (30%), Positives = 105/241 (43%), Gaps = 42/241 (17%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
GHT +LS CC +++ TSSGDTT LWD+ G TF GH+ V S +
Sbjct: 141 GHTGYLS-CCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLF 199
Query: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
S + D ++K+WDV CR T GH +N+I FFP N T S D T ++D R
Sbjct: 200 VSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR--- 256
Query: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
+Q L + H D I CG+T V+F
Sbjct: 257 ADQELMTYSH---DNII------------CGIT----------------------SVSFS 279
Query: 572 SSGRVLAQASGNGVIHLLD-LKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
SGR+L + ++ D LK+ L GH+N + + DG + +G D ++ W
Sbjct: 280 KSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Query: 631 S 631
+
Sbjct: 340 N 340
Score = 80.9 bits (198), Expect = 3e-15
Identities = 62/231 (26%), Positives = 97/231 (41%), Gaps = 12/231 (5%)
Query: 409 LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE 468
L ++S D + +WD + + S V +C + GN+VA LD I+++ +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129
Query: 469 ----RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSIN 524
R L GHT ++ F N ++TSS D T ++WD TG + GH +
Sbjct: 130 EGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVM 188
Query: 525 DAIFDPRGHMIAS--CDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASG 582
P + S CDA KLWD R+ + + S N + F +G A S
Sbjct: 189 SLSLAPDTRLFVSGACDAS--AKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSD 246
Query: 583 NGVIHLLDLKSGEIHKLMGHEN---EAHTVVFSHDGEILFSGGSDGTVRTW 630
+ L DL++ + H+N +V FS G +L +G D W
Sbjct: 247 DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297
Score = 52.8 bits (125), Expect = 1e-06
Identities = 40/161 (24%), Positives = 67/161 (41%), Gaps = 2/161 (1%)
Query: 348 FRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD 407
F H V +S+ P + VS D K+ + + T GH ++ CF P+G+
Sbjct: 180 FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 239
Query: 408 KLATSSGDTTVKLWDLCKGDCILTFEGHS--RAVWSCTWHSCGNFVASSSLDKTSKIWDV 465
AT S D T +L+DL ++T+ + + S ++ G + + D +WD
Sbjct: 240 AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA 299
Query: 466 NSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506
L GH + V+ + + T S D L IW+
Sbjct: 300 LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 38.5 bits (88), Expect = 0.019
Identities = 33/168 (19%), Positives = 69/168 (41%), Gaps = 8/168 (4%)
Query: 469 RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIF 528
R R TL GH + ++ + S L+++S D L IWD+ T ++ + +
Sbjct: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105
Query: 529 DPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVL-----AQASGN 583
P G+ +A + +++ + ++ + + S R L +SG+
Sbjct: 106 APSGNYVACGGLDNICSIYNLKTREG--NVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 163
Query: 584 GVIHLLDLKSG-EIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
L D+++G + GH + ++ + D + SG D + + W
Sbjct: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 100 bits (249), Expect = 4e-21
Identities = 77/284 (27%), Positives = 122/284 (42%), Gaps = 9/284 (3%)
Query: 311 GNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSC 370
GNTK+S P + K P +KL + H V C++++P V+
Sbjct: 170 GNTKNSALMAKKAPT----MPKPQWHPP---WKLYRVISGHLGWVRCIAVEPGNQWFVTG 222
Query: 371 GEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCIL 430
DR K+ L + L+ GH + L + D VK WDL I
Sbjct: 223 SADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIR 282
Query: 431 TFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFS 490
+ GH AV+ H + + + S D T++IWDV ++ TL GHT++V ++
Sbjct: 283 HYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAE 342
Query: 491 NTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR 550
++T S D T+ +WD G +L H S+ + PR + AS + K W F
Sbjct: 343 PQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNI-KQWKFP 401
Query: 551 KLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSG 594
I ++ + N + +S G VL + NG +HL D ++G
Sbjct: 402 DGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTG 444
Score = 63.5 bits (153), Expect = 6e-10
Identities = 44/166 (26%), Positives = 67/166 (40%), Gaps = 21/166 (12%)
Query: 476 GHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMI 535
GH V I P + +T SAD+T+ IWD +G + SL GH+ ++ I R +
Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
Query: 536 ASCDACGVTKLWDFR----------KLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGV 585
SC K WD L + +D+ P+ VL S +
Sbjct: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTID----------VLVTCSRDST 311
Query: 586 IHLLDLKS-GEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
+ D+++ +H L GH N TV + +G D T+R W
Sbjct: 312 ARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
Score = 49.3 bits (116), Expect = 1e-05
Identities = 59/256 (23%), Positives = 93/256 (36%), Gaps = 57/256 (22%)
Query: 304 KCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCV---SM 360
K K + G+ I +P L E +D + + R + +S V +
Sbjct: 237 KLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDL 296
Query: 361 QPHKDILVSCGED---RLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTT 417
P D+LV+C D R+W V + L GHT+ ++ + ++ T S DTT
Sbjct: 297 HPTIDVLVTCSRDSTARIWDVRTKASVHTLS---GHTNAVATVRCQAAEPQIITGSHDTT 353
Query: 418 VKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDK------------------- 458
++LWDL G +T H ++V + H AS S D
Sbjct: 354 IRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHN 413
Query: 459 ---------------------TSKIWD----VNSERCRCTLY-GHTDSVNSIEFFPFSNT 492
T +WD N +R + G DS + I F +
Sbjct: 414 AIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQS 473
Query: 493 ---LLTSSADKTLSIW 505
LLT+ ADKT+ ++
Sbjct: 474 ESRLLTAEADKTIKVY 489
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 99.4 bits (246), Expect = 9e-21
Identities = 63/208 (30%), Positives = 100/208 (48%), Gaps = 14/208 (6%)
Query: 358 VSMQPHKDILVSCGEDRLWKVLGLPK----CNVLLTGFGHTDWLSDCCFHPSGDKLATSS 413
++ P +L SCG DR ++ G C +L+ GH + + P G+ LA++S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSE-GHQRTVRKVAWSPCGNYLASAS 80
Query: 414 GDTTVKLWDLCKGD--CILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE--- 468
D T +W + D C+ T EGH V S W GN +A+ S DK+ +W+V+ E
Sbjct: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEY 140
Query: 469 RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIW--DARTGICEQSLYGHMHSINDA 526
C L HT V + + P L ++S D T+ ++ + +C +L GH ++
Sbjct: 141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200
Query: 527 IFDPRGHMIASCDACGVTKLWDFRKLLP 554
FDP G +ASC ++W R+ LP
Sbjct: 201 AFDPSGQRLASCSDDRTVRIW--RQYLP 226
Score = 89.7 bits (221), Expect = 7e-18
Identities = 57/200 (28%), Positives = 94/200 (47%), Gaps = 16/200 (8%)
Query: 402 FHPSGDKLATSSGDTTVKLWD------LCKGDCILTFEGHSRAVWSCTWHSCGNFVASSS 455
++P+G LA+ GD +++W +CK + EGH R V W CGN++AS+S
Sbjct: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKS---VLSEGHQRTVRKVAWSPCGNYLASAS 80
Query: 456 LDKTSKIWDVNSE--RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG--- 510
D T+ IW N + C TL GH + V S+ + P N L T S DK++ +W+
Sbjct: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEY 140
Query: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLW--DFRKLLPIVSIDIGPSPGNEV 568
C L H + ++ P ++AS KL+ + + +++ S +
Sbjct: 141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200
Query: 569 NFDSSGRVLAQASGNGVIHL 588
FD SG+ LA S + + +
Sbjct: 201 AFDPSGQRLASCSDDRTVRI 220
Score = 81.3 bits (199), Expect = 3e-15
Identities = 64/242 (26%), Positives = 106/242 (43%), Gaps = 31/242 (12%)
Query: 341 DYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDR---LWKVLGLPKCNVLLTGFGHTDWL 397
D++ HE V V+ P ++L +C D+ +W+V + + HT +
Sbjct: 94 DFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDV 153
Query: 398 SDCCFHPSGDKLATSSGDTTVKLWDLCKGD--CILTFEGHSRAVWSCTWHSCGNFVASSS 455
+HPS + LA++S D TVKL+ + D C T EGH VWS + G +AS S
Sbjct: 154 KHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCS 213
Query: 456 LDKTSKIW---------------DVNSERCRCTLYG-HTDSVNSIEFFPFSNTLLTSSAD 499
D+T +IW S +C CTL G H+ ++ I + + L T+ D
Sbjct: 214 DDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGD 273
Query: 500 KTLSIWDARTGICEQ----SLYGHMH-----SINDAIFDPR-GHMIASCDACGVTKLWDF 549
+ ++ Q SL H+H +N ++P+ ++ASC G W +
Sbjct: 274 DAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKY 333
Query: 550 RK 551
++
Sbjct: 334 QR 335
Score = 69.7 bits (169), Expect = 8e-12
Identities = 51/202 (25%), Positives = 86/202 (42%), Gaps = 11/202 (5%)
Query: 440 WSCTWHSCGNFVASSSLDKTSKIWDVNSER--CRCTLY-GHTDSVNSIEFFPFSNTLLTS 496
W W+ G +AS D+ +IW + C+ L GH +V + + P N L ++
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
Query: 497 SADKTLSIWDARTGI--CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLP 554
S D T IW C +L GH + + + P G+++A+C +W+ +
Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139
Query: 555 IVSIDIGPSPGNEVN---FDSSGRVLAQASGNGVIHLLDLKSGE---IHKLMGHENEAHT 608
+ + S +V + S +LA AS + + L + + L GHE+ +
Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 609 VVFSHDGEILFSGGSDGTVRTW 630
+ F G+ L S D TVR W
Sbjct: 200 LAFDPSGQRLASCSDDRTVRIW 221
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 99.4 bits (246), Expect = 9e-21
Identities = 99/412 (24%), Positives = 161/412 (39%), Gaps = 102/412 (24%)
Query: 317 EFPIDMQPNP-----NLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCG 371
+ P+D+ P+ N +++E P F I + +++ K + +
Sbjct: 34 DVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSSLGKTLESQAVETEKVLDIIYQ 93
Query: 372 EDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDL-------- 423
+++V + +C L G H++ + F P+G LA+ SGDTTV+ WDL
Sbjct: 94 PQAIFRVRAVTRCTSSLEG--HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFT 151
Query: 424 -----------------------CKGDCIL------------TFEGHSRAVWSCTWH--- 445
CK IL T GHS+ + +W
Sbjct: 152 CKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLH 211
Query: 446 ---SCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTL 502
C +VASSS D + +IWD + RC L GHT SV + + L ++S D+T+
Sbjct: 212 ANPEC-RYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLR-WGGDGLLYSASQDRTI 269
Query: 503 SIWDARTGICEQSLYGHMHSIN-----------DAIFDPRGHMIASCDACG--------- 542
+W A G+ ++L GH H +N F+P + D G
Sbjct: 270 KVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERA 329
Query: 543 ---------------VTKLWDFRKLL--------PIVSIDIGPSPGNEVNFDSSGRVLAQ 579
V+ DF L P+ + + N+V F R++A
Sbjct: 330 LSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVAS 389
Query: 580 ASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
AS + I L D ++G+ + L GH + + +S D +L SG SD T++ W
Sbjct: 390 ASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Score = 85.9 bits (211), Expect = 1e-16
Identities = 72/288 (25%), Positives = 120/288 (41%), Gaps = 50/288 (17%)
Query: 392 GHTDWLSDCCFHPSGDK-----LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHS 446
GH+ W++ + P +A+SS D +V++WD G C GH+++V W
Sbjct: 197 GHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGG 256
Query: 447 CGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIE-----------FFPFSNT--- 492
G + S+S D+T K+W + TL GH VN++ F P +
Sbjct: 257 DG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNP 315
Query: 493 ----------------------------LLTSSADKTLSIWD-ARTGICEQSLYGHMHSI 523
L++ S D TL +W A + GH I
Sbjct: 316 QDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALI 375
Query: 524 NDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGN 583
N +F P ++AS KLWD R + S+ + ++ + + R+L S +
Sbjct: 376 NQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSD 435
Query: 584 GVIHLLDLKSGEIHK-LMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
+ + D+K+ ++ L GH +E + V +S DG+ + SGG D +R W
Sbjct: 436 STLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 98.6 bits (244), Expect = 2e-20
Identities = 68/245 (27%), Positives = 113/245 (46%), Gaps = 8/245 (3%)
Query: 394 TDWLSDCCFHPSGDKLATSSGDTTVKLWDLC--KGDCILTFE--GHSRAVWSCTWHSCGN 449
+ W+ C + PSG+ +A D +++L +G+ ++ E GH+ + C +
Sbjct: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ 156
Query: 450 FVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDART 509
V SS D T +WD+ + + T GH+ V S+ P T ++ + D + +WD R
Sbjct: 157 IVTSSG-DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRD 215
Query: 510 GICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSIDIGPSPGNE 567
G+C QS GH+ IN F P G+ A+ +L+D R + L + S D
Sbjct: 216 GMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITS 275
Query: 568 VNFDSSGRVLAQASGNGVIHLLD-LKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGT 626
V F SGR+L + ++ D LK L GH+N + + DG + +G D
Sbjct: 276 VAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 627 VRTWS 631
+R W+
Sbjct: 336 LRIWN 340
Score = 62.4 bits (150), Expect = 1e-09
Identities = 60/251 (23%), Positives = 91/251 (36%), Gaps = 54/251 (21%)
Query: 431 TFEGHSRAVW------------------------------------------SCTWHSCG 448
T GH ++ +C + G
Sbjct: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
Query: 449 NFVASSSLDKTSKIWDVNSE----RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSI 504
N+VA LD I+++ + R L GHT ++ F S ++TSS D T ++
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCAL 168
Query: 505 WDARTGICEQSLYGHMHSINDAIFDP--RGHMIASCDACGVTKLWDFRKLLPIVSIDIGP 562
WD T + GH + P R + +CDA +KLWD R + S
Sbjct: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDAS--SKLWDIRDGMCRQSFTGHV 226
Query: 563 SPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHEN---EAHTVVFSHDGEILF 619
S N V+F +G A S + L DL++ + L H+N +V FS G +L
Sbjct: 227 SDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLL 286
Query: 620 SGGSDGTVRTW 630
+G D W
Sbjct: 287 AGYDDFNCNVW 297
Score = 36.2 bits (82), Expect = 0.094
Identities = 39/184 (21%), Positives = 76/184 (41%), Gaps = 12/184 (6%)
Query: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512
+S++D +I R R TL GH + ++ + S L+++S D L IWD+ T
Sbjct: 34 TSNMDSVGRI----QMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNK 89
Query: 513 EQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDS 572
++ + + P G+ +A + +++ + V + PG+ + S
Sbjct: 90 MHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVS-RELPGH-TGYLS 147
Query: 573 SGRVL-----AQASGNGVIHLLDLKSG-EIHKLMGHENEAHTVVFSHDGEILFSGGSDGT 626
R L +SG+ L D+++ + GH + ++ S D SG D +
Sbjct: 148 CCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDAS 207
Query: 627 VRTW 630
+ W
Sbjct: 208 SKLW 211
Score = 35.4 bits (80), Expect = 0.16
Identities = 31/127 (24%), Positives = 47/127 (37%), Gaps = 4/127 (3%)
Query: 341 DYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTD---WL 397
D + F H ++ VS P+ + +D ++ L LL + H + +
Sbjct: 215 DGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLL-YSHDNIICGI 273
Query: 398 SDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLD 457
+ F SG L D +WD KGD GH V G VA+ S D
Sbjct: 274 TSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333
Query: 458 KTSKIWD 464
+IW+
Sbjct: 334 SFLRIWN 340
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 98.6 bits (244), Expect = 2e-20
Identities = 70/241 (29%), Positives = 101/241 (41%), Gaps = 42/241 (17%)
Query: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
GHT +LS CC +++ TSSGDTT LWD+ G + F GHS V S + G
Sbjct: 141 GHTGYLS-CCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTF 199
Query: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
S + D + K+WDV CR T GH +N++ FFP T S D T ++D R
Sbjct: 200 VSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRAD- 258
Query: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
E +Y H + I CG+T V F
Sbjct: 259 QELLMYSHDNII-----------------CGIT----------------------SVAFS 279
Query: 572 SSGRVLAQASGNGVIHLLD-LKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
SGR+L + ++ D +K L GH+N + + DG + +G D ++ W
Sbjct: 280 RSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Query: 631 S 631
+
Sbjct: 340 N 340
Score = 82.0 bits (201), Expect = 1e-15
Identities = 72/282 (25%), Positives = 111/282 (39%), Gaps = 18/282 (6%)
Query: 364 KDILVSCGEDRLWKV------LGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTT 417
+D +CG+ L ++ +G + T GH + + L ++S D
Sbjct: 19 RDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGK 78
Query: 418 VKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE----RCRCT 473
+ +WD + + S V +C + GNFVA LD I+ + + R
Sbjct: 79 LIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRE 138
Query: 474 LYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGH 533
L GHT ++ F N ++TSS D T ++WD TG GH + P G
Sbjct: 139 LPGHTGYLSCCRFLD-DNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGR 197
Query: 534 MIAS--CDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL 591
S CDA KLWD R + + S N V F +G S + L DL
Sbjct: 198 TFVSGACDAS--IKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDL 255
Query: 592 KSGEIHKLMGHEN---EAHTVVFSHDGEILFSGGSDGTVRTW 630
++ + + H+N +V FS G +L +G D W
Sbjct: 256 RADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIW 297
Score = 45.4 bits (106), Expect = 2e-04
Identities = 41/162 (25%), Positives = 60/162 (37%), Gaps = 4/162 (2%)
Query: 348 FRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD 407
F H V +S+ P VS D K+ + T GH ++ F P+G
Sbjct: 180 FAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGY 239
Query: 408 KLATSSGDTTVKLWDLCKGDCILTFEGHSR---AVWSCTWHSCGNFVASSSLDKTSKIWD 464
T S D T +L+DL + D L H + S + G + + D IWD
Sbjct: 240 AFTTGSDDATCRLFDL-RADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
Query: 465 VNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506
L GH + V+ + + T S D L IW+
Sbjct: 299 AMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 38.1 bits (87), Expect = 0.025
Identities = 32/127 (25%), Positives = 48/127 (37%), Gaps = 4/127 (3%)
Query: 341 DYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTD---WL 397
D + F HE ++ V+ P+ + +D ++ L LL + H + +
Sbjct: 215 DSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLM-YSHDNIICGI 273
Query: 398 SDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLD 457
+ F SG L D +WD KGD GH V G VA+ S D
Sbjct: 274 TSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333
Query: 458 KTSKIWD 464
KIW+
Sbjct: 334 SFLKIWN 340
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 98.2 bits (243), Expect = 2e-20
Identities = 80/307 (26%), Positives = 133/307 (43%), Gaps = 17/307 (5%)
Query: 339 KFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDR---LWKVLGLPKCNVLLTGFGHTD 395
+F K + + H V C+ K +VS +D +W K + +
Sbjct: 50 QFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP---CT 106
Query: 396 WLSDCCFHPSGDKLATSSGDTTVKLWDLC--KGDCILTFEG----HSRAVWSCTWHSCGN 449
W+ C + PSG +A D ++ L K + + + H+ + +C++ +
Sbjct: 107 WVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDM 166
Query: 450 FVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFS--NTLLTSSADKTLSIWDA 507
+ ++S D T +WDV S + + +GH V ++ P NT ++ DK +WD
Sbjct: 167 QILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 226
Query: 508 RTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSIDIGPSPG 565
R+G C Q+ H IN + P G AS +L+D R + + I S +
Sbjct: 227 RSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGA 286
Query: 566 NEVNFDSSGRVLAQASGNGVIHLLD-LKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSD 624
+ V+F SGR+L + I++ D LK + L GHEN T+ S DG SG D
Sbjct: 287 SSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWD 346
Query: 625 GTVRTWS 631
T+R W+
Sbjct: 347 HTLRVWA 353
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/274 (23%), Positives = 110/274 (40%), Gaps = 28/274 (10%)
Query: 284 KENAPEGPTQKGLREAREQNKCKTKMKG-NTKDSEFPIDMQPNPNLNVSKESLSPAKFDY 342
KE+A P + A + C G + K S +P+ N N+ K+S++
Sbjct: 97 KEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVA------ 150
Query: 343 KLKNIFRLHELPVS-CVSMQPHKDILVSCGEDR--LWKVLGLPKCNVLLTGF-GH-TDWL 397
+H +S C IL + G+ LW V + LL F GH D L
Sbjct: 151 -------MHTNYLSACSFTNSDMQILTASGDGTCALWDV----ESGQLLQSFHGHGADVL 199
Query: 398 S-DCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSL 456
D +G+ + D +WD+ G C+ FE H + S ++ G+ AS S
Sbjct: 200 CLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSD 259
Query: 457 DKTSKIWDVNSERCRCTLYGHTDSV---NSIEFFPFSNTLLTSSADKTLSIWDARTGICE 513
D T +++D+ ++R +Y + +S++F L D T+++WD G
Sbjct: 260 DATCRLYDLRADR-EVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 318
Query: 514 QSLYGHMHSINDAIFDPRGHMIASCDACGVTKLW 547
L+GH + ++ P G S ++W
Sbjct: 319 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,005,551
Number of Sequences: 37866
Number of extensions: 1175505
Number of successful extensions: 7562
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 236
Number of HSP's successfully gapped in prelim test: 225
Number of HSP's that attempted gapping in prelim test: 4356
Number of HSP's gapped (non-prelim): 1883
length of query: 631
length of database: 18,247,518
effective HSP length: 108
effective length of query: 523
effective length of database: 14,157,990
effective search space: 7404628770
effective search space used: 7404628770
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.