Guide to the Human Genome
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Search of human proteins with 13677216

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13677216 receptor-type protein tyrosine phosphatase O
isoform d precursor [Homo sapiens]
         (377 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13677220 receptor-type protein tyrosine phosphatase O isoform...   773   0.0  
gi|13677216 receptor-type protein tyrosine phosphatase O isoform...   773   0.0  
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ...   773   0.0  
gi|13677222 receptor-type protein tyrosine phosphatase O isoform...   758   0.0  
gi|13677218 receptor-type protein tyrosine phosphatase O isoform...   758   0.0  
gi|13677214 receptor-type protein tyrosine phosphatase O isoform...   758   0.0  
gi|157952215 protein tyrosine phosphatase, receptor type, B isof...   303   2e-82
gi|157952213 protein tyrosine phosphatase, receptor type, B isof...   303   2e-82
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom...   286   2e-77
gi|148728162 protein tyrosine phosphatase, receptor type, J isof...   279   3e-75
gi|241896926 protein tyrosine phosphatase, receptor type, H isof...   266   2e-71
gi|241896924 protein tyrosine phosphatase, receptor type, H isof...   266   2e-71
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   228   9e-60
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   228   9e-60
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   225   4e-59
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   225   4e-59
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   225   4e-59
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...   225   4e-59
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   224   1e-58
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   223   2e-58
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   223   2e-58
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   223   2e-58
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   223   2e-58
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   222   4e-58
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   222   4e-58
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   220   2e-57
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   220   2e-57
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   220   2e-57
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   219   3e-57
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   219   3e-57

>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
           precursor [Homo sapiens]
          Length = 377

 Score =  773 bits (1995), Expect = 0.0
 Identities = 377/377 (100%), Positives = 377/377 (100%)

Query: 1   MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
           MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1   MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60

Query: 61  LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
           LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL
Sbjct: 61  LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120

Query: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
           PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN
Sbjct: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180

Query: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
           DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR
Sbjct: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240

Query: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300
           HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG
Sbjct: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300

Query: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360
           VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
Sbjct: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360

Query: 361 KQQFCISDVIYENVSKS 377
           KQQFCISDVIYENVSKS
Sbjct: 361 KQQFCISDVIYENVSKS 377


>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
           precursor [Homo sapiens]
          Length = 377

 Score =  773 bits (1995), Expect = 0.0
 Identities = 377/377 (100%), Positives = 377/377 (100%)

Query: 1   MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
           MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1   MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60

Query: 61  LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
           LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL
Sbjct: 61  LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120

Query: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
           PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN
Sbjct: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180

Query: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
           DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR
Sbjct: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240

Query: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300
           HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG
Sbjct: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300

Query: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360
           VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
Sbjct: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360

Query: 361 KQQFCISDVIYENVSKS 377
           KQQFCISDVIYENVSKS
Sbjct: 361 KQQFCISDVIYENVSKS 377


>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
            precursor [Homo sapiens]
          Length = 1188

 Score =  773 bits (1995), Expect = 0.0
 Identities = 377/377 (100%), Positives = 377/377 (100%)

Query: 1    MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
            MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 812  MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 871

Query: 61   LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
            LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL
Sbjct: 872  LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 931

Query: 121  PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
            PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN
Sbjct: 932  PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 991

Query: 181  DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
            DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR
Sbjct: 992  DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 1051

Query: 241  HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300
            HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG
Sbjct: 1052 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 1111

Query: 301  VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360
            VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
Sbjct: 1112 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 1171

Query: 361  KQQFCISDVIYENVSKS 377
            KQQFCISDVIYENVSKS
Sbjct: 1172 KQQFCISDVIYENVSKS 1188


>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
           precursor [Homo sapiens]
          Length = 405

 Score =  758 bits (1956), Expect = 0.0
 Identities = 377/405 (93%), Positives = 377/405 (93%), Gaps = 28/405 (6%)

Query: 1   MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
           MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1   MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60

Query: 61  LPYNW----------------------------SKNGLKKRKLTNPVQLDDFDAYIKDMA 92
           LPYNW                            SKNGLKKRKLTNPVQLDDFDAYIKDMA
Sbjct: 61  LPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMA 120

Query: 93  KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 152
           KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD
Sbjct: 121 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 180

Query: 153 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 212
           YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW
Sbjct: 181 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 240

Query: 213 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 272
           PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA
Sbjct: 241 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 300

Query: 273 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 332
           ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM
Sbjct: 301 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 360

Query: 333 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 377
           RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS
Sbjct: 361 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 405


>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
           precursor [Homo sapiens]
          Length = 405

 Score =  758 bits (1956), Expect = 0.0
 Identities = 377/405 (93%), Positives = 377/405 (93%), Gaps = 28/405 (6%)

Query: 1   MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
           MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1   MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60

Query: 61  LPYNW----------------------------SKNGLKKRKLTNPVQLDDFDAYIKDMA 92
           LPYNW                            SKNGLKKRKLTNPVQLDDFDAYIKDMA
Sbjct: 61  LPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMA 120

Query: 93  KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 152
           KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD
Sbjct: 121 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 180

Query: 153 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 212
           YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW
Sbjct: 181 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 240

Query: 213 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 272
           PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA
Sbjct: 241 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 300

Query: 273 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 332
           ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM
Sbjct: 301 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 360

Query: 333 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 377
           RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS
Sbjct: 361 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 405


>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
            precursor [Homo sapiens]
          Length = 1216

 Score =  758 bits (1956), Expect = 0.0
 Identities = 377/405 (93%), Positives = 377/405 (93%), Gaps = 28/405 (6%)

Query: 1    MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
            MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 812  MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 871

Query: 61   LPYNW----------------------------SKNGLKKRKLTNPVQLDDFDAYIKDMA 92
            LPYNW                            SKNGLKKRKLTNPVQLDDFDAYIKDMA
Sbjct: 872  LPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMA 931

Query: 93   KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 152
            KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD
Sbjct: 932  KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 991

Query: 153  YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 212
            YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW
Sbjct: 992  YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 1051

Query: 213  PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 272
            PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA
Sbjct: 1052 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 1111

Query: 273  ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 332
            ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM
Sbjct: 1112 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 1171

Query: 333  RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 377
            RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS
Sbjct: 1172 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 1216


>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
            [Homo sapiens]
          Length = 2215

 Score =  303 bits (776), Expect = 2e-82
 Identities = 165/364 (45%), Positives = 234/364 (64%), Gaps = 17/364 (4%)

Query: 22   LIGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPV 79
            LIG+L+  V L+I R+K +   RE  +       S+ RD  L  + +      RK + P+
Sbjct: 1847 LIGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPI 1901

Query: 80   QLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSR 139
            +++ F+ +   +  DS+Y  S ++EELK +G +     A LP NR KNRY NILPYD +R
Sbjct: 1902 KINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATR 1961

Query: 140  VRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQ 199
            V+L +++++  +DYINA+YIPG N  +EYI TQGPLP T++DFWKMV +Q    IVM+TQ
Sbjct: 1962 VKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ 2021

Query: 200  CNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHF 256
            C EK RVKCDHYWP  ++ + YGD+ ++M+SE    +W  R F+I      D  + + HF
Sbjct: 2022 CVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHF 2081

Query: 257  NYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLL 314
            +YT WPDHGVP     +S++QFV  VR    +S   GP ++HCSAGVGRTGTFIALDR+L
Sbjct: 2082 HYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRIL 2139

Query: 315  QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIY 371
            Q +   + VDI G V ++R +R+ MVQTE QY+++HQCV+ +   +K   +Q      IY
Sbjct: 2140 QQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIY 2199

Query: 372  ENVS 375
            ENV+
Sbjct: 2200 ENVN 2203


>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
            precursor [Homo sapiens]
          Length = 1997

 Score =  303 bits (776), Expect = 2e-82
 Identities = 165/364 (45%), Positives = 234/364 (64%), Gaps = 17/364 (4%)

Query: 22   LIGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPV 79
            LIG+L+  V L+I R+K +   RE  +       S+ RD  L  + +      RK + P+
Sbjct: 1629 LIGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPI 1683

Query: 80   QLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSR 139
            +++ F+ +   +  DS+Y  S ++EELK +G +     A LP NR KNRY NILPYD +R
Sbjct: 1684 KINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATR 1743

Query: 140  VRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQ 199
            V+L +++++  +DYINA+YIPG N  +EYI TQGPLP T++DFWKMV +Q    IVM+TQ
Sbjct: 1744 VKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ 1803

Query: 200  CNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHF 256
            C EK RVKCDHYWP  ++ + YGD+ ++M+SE    +W  R F+I      D  + + HF
Sbjct: 1804 CVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHF 1863

Query: 257  NYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLL 314
            +YT WPDHGVP     +S++QFV  VR    +S   GP ++HCSAGVGRTGTFIALDR+L
Sbjct: 1864 HYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRIL 1921

Query: 315  QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIY 371
            Q +   + VDI G V ++R +R+ MVQTE QY+++HQCV+ +   +K   +Q      IY
Sbjct: 1922 QQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIY 1981

Query: 372  ENVS 375
            ENV+
Sbjct: 1982 ENVN 1985


>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
            sapiens]
          Length = 2299

 Score =  286 bits (732), Expect = 2e-77
 Identities = 156/388 (40%), Positives = 222/388 (57%), Gaps = 20/388 (5%)

Query: 2    VTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQ-----------MARECGAGTFV 50
            ++E    +++   L ILS +L+G  +     +R+K  +           +  +      +
Sbjct: 1899 LSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLI 1958

Query: 51   NFASLE-RDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLI 109
              A LE +D +L        L  RK   P+    F  +++++  +++ KF  +F EL   
Sbjct: 1959 TVADLELKDERLT-----RLLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKF 2013

Query: 110  GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYI 169
              D+    ADLP NR KNR+ NI PY+ +RV+L++     G+DYINA+YI GY  P E+I
Sbjct: 2014 LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFI 2073

Query: 170  ATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEM 228
            ATQGPLP T  DFW+MV + +++ +VMLTQC EK R++C  YWP   +P+  +GDI +  
Sbjct: 2074 ATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITK 2133

Query: 229  ISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATK 288
            + E+ Q DW  R  +I    +   V   N+TAWP+HGVP  +A   ++ FV +VR     
Sbjct: 2134 LMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA--PLIHFVKLVRASRAH 2191

Query: 289  SKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIF 348
               PMI+HCSAGVGRTG FIALD L QHI DH+FVDI GLV+E+RS RM MVQ   QYIF
Sbjct: 2192 DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIF 2251

Query: 349  IHQCVQLMWMKKKQQFCISDVIYENVSK 376
            +HQC+  +   K     I  V Y  + K
Sbjct: 2252 LHQCILDLLSNKGSNQPICFVNYSALQK 2279


>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
            precursor [Homo sapiens]
          Length = 1337

 Score =  279 bits (714), Expect = 3e-75
 Identities = 145/334 (43%), Positives = 220/334 (65%), Gaps = 14/334 (4%)

Query: 47   GTFVNFASLERDGKL-PYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEE 105
            G F+ +    +D K    ++S+   KK KL   +++++F+AY K    DS+  F+ ++E+
Sbjct: 991  GGFIFWRKKRKDAKNNEVSFSQIKPKKSKL---IRVENFEAYFKKQQADSNCGFAEEYED 1047

Query: 106  LKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSP 165
            LKL+G+  P +AA+L  NR KNRY N+LPYD SRV+L S+      DYINANY+PGY+S 
Sbjct: 1048 LKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSK 1106

Query: 166  QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDIT 225
            +++IATQGPLP T  DFW+MV ++    I+MLT+C E+ R KC+ YWP +++   YGDIT
Sbjct: 1107 KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDIT 1165

Query: 226  VEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVR 283
            V M SE    +W  R F +      E   +  F++T+WPDHGVP  +  + ++ F ++VR
Sbjct: 1166 VAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVR 1223

Query: 284  QQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQ 341
                +S  + P+++HCSAGVGRTGTFIA+DRL+  I +   VD+ G+V ++R +R  MVQ
Sbjct: 1224 DYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQ 1283

Query: 342  TEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVS 375
            TE+QY+F++QCV  + + + Q+    D+IY+N +
Sbjct: 1284 TEDQYVFLNQCV--LDIVRSQKDSKVDLIYQNTT 1315


>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform
           2 precursor [Homo sapiens]
          Length = 937

 Score =  266 bits (681), Expect = 2e-71
 Identities = 131/300 (43%), Positives = 189/300 (63%), Gaps = 6/300 (2%)

Query: 79  VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
           +  +DF  +++   +DS+  F+ ++++L L+G       A    N  KNRY N+LPYD+S
Sbjct: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681

Query: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
           RV L  ++EE G+DYINA+++PG  SPQE+IATQGPLP+T  DFW++V +Q+S  +VMLT
Sbjct: 682 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 741

Query: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHF 256
            C E  RVKC+HYWP   +P  +G + V ++ EE  ++W  R   +   +E +   V  F
Sbjct: 742 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 801

Query: 257 NYTAWPDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLL 314
           +Y AWPDHGVP  ++ +++L F  M+RQ    T   GP I+HCSAGVGRTGT IALD LL
Sbjct: 802 HYQAWPDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLL 859

Query: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 374
           + ++    +     V +MR  R  MVQTE QY+F+HQC+     +  Q     +V YE+V
Sbjct: 860 RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 919


>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
            precursor [Homo sapiens]
          Length = 1115

 Score =  266 bits (681), Expect = 2e-71
 Identities = 131/300 (43%), Positives = 189/300 (63%), Gaps = 6/300 (2%)

Query: 79   VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
            +  +DF  +++   +DS+  F+ ++++L L+G       A    N  KNRY N+LPYD+S
Sbjct: 800  IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859

Query: 139  RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
            RV L  ++EE G+DYINA+++PG  SPQE+IATQGPLP+T  DFW++V +Q+S  +VMLT
Sbjct: 860  RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919

Query: 199  QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHF 256
             C E  RVKC+HYWP   +P  +G + V ++ EE  ++W  R   +   +E +   V  F
Sbjct: 920  NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 979

Query: 257  NYTAWPDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLL 314
            +Y AWPDHGVP  ++ +++L F  M+RQ    T   GP I+HCSAGVGRTGT IALD LL
Sbjct: 980  HYQAWPDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLL 1037

Query: 315  QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 374
            + ++    +     V +MR  R  MVQTE QY+F+HQC+     +  Q     +V YE+V
Sbjct: 1038 RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 1097


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  228 bits (580), Expect = 9e-60
 Identities = 129/344 (37%), Positives = 193/344 (56%), Gaps = 14/344 (4%)

Query: 17   ILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPY-----NWSKNGLK 71
            +L+ +LI L+++ +++ ++K           +     SL      P      N+   G++
Sbjct: 1268 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327

Query: 72   KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 131
                  P+ + D    I+ +  +   KFS ++E +   G       ++L +N+ KNRY N
Sbjct: 1328 DHP---PIPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYAN 1383

Query: 132  ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 191
            ++ YD SRV L S++   G+DYINANYI GY     YIATQGPLPET  DFW+MV +Q++
Sbjct: 1384 VIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRT 1443

Query: 192  QIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADE 249
              +VM+T+  EK RVKCD YWP        G I V ++   E   +  R F ++   + E
Sbjct: 1444 ATVVMMTRLEEKSRVKCDQYWP-ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSE 1502

Query: 250  MQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIA 309
             +++  F + AWPDHGVP       IL F+  V+       GPM++HCSAGVGRTG FI 
Sbjct: 1503 KRELRQFQFMAWPDHGVP--EYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1560

Query: 310  LDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
            +D +L+ ++  + VDI G V+ MRS R  MVQTE+QY+FIH+ +
Sbjct: 1561 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1604



 Score =  188 bits (477), Expect = 8e-48
 Identities = 103/251 (41%), Positives = 145/251 (57%), Gaps = 13/251 (5%)

Query: 105  ELKLIGLDIPH----FAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIP 160
            E KL+     H     +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA+++ 
Sbjct: 1642 EFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLD 1701

Query: 161  GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIA 220
            GY   + YIATQGPL E+  DFW+M+ +  S IIVMLT+  E  R KC  YWP  E    
Sbjct: 1702 GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP-AERSAR 1760

Query: 221  YGDITVEMISEEEQDDWACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF 278
            Y    V+ ++E     +  R F++  A + Q   +  F +T WP+ GVP     E  + F
Sbjct: 1761 YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP--KTGEGFIDF 1818

Query: 279  ---VHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSY 335
               VH  ++Q  +  GP+ +HCSAGVGRTG FI L  +L+ +R    VD+   V  +R+ 
Sbjct: 1819 IGQVHKTKEQFGQD-GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQ 1877

Query: 336  RMSMVQTEEQY 346
            R +MVQTE+QY
Sbjct: 1878 RPAMVQTEDQY 1888


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  228 bits (580), Expect = 9e-60
 Identities = 129/344 (37%), Positives = 193/344 (56%), Gaps = 14/344 (4%)

Query: 17   ILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPY-----NWSKNGLK 71
            +L+ +LI L+++ +++ ++K           +     SL      P      N+   G++
Sbjct: 1259 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318

Query: 72   KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 131
                  P+ + D    I+ +  +   KFS ++E +   G       ++L +N+ KNRY N
Sbjct: 1319 DHP---PIPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYAN 1374

Query: 132  ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 191
            ++ YD SRV L S++   G+DYINANYI GY     YIATQGPLPET  DFW+MV +Q++
Sbjct: 1375 VIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRT 1434

Query: 192  QIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADE 249
              +VM+T+  EK RVKCD YWP        G I V ++   E   +  R F ++   + E
Sbjct: 1435 ATVVMMTRLEEKSRVKCDQYWP-ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSE 1493

Query: 250  MQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIA 309
             +++  F + AWPDHGVP       IL F+  V+       GPM++HCSAGVGRTG FI 
Sbjct: 1494 KRELRQFQFMAWPDHGVP--EYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1551

Query: 310  LDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
            +D +L+ ++  + VDI G V+ MRS R  MVQTE+QY+FIH+ +
Sbjct: 1552 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1595



 Score =  188 bits (477), Expect = 8e-48
 Identities = 103/251 (41%), Positives = 145/251 (57%), Gaps = 13/251 (5%)

Query: 105  ELKLIGLDIPH----FAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIP 160
            E KL+     H     +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA+++ 
Sbjct: 1633 EFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLD 1692

Query: 161  GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIA 220
            GY   + YIATQGPL E+  DFW+M+ +  S IIVMLT+  E  R KC  YWP  E    
Sbjct: 1693 GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP-AERSAR 1751

Query: 221  YGDITVEMISEEEQDDWACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF 278
            Y    V+ ++E     +  R F++  A + Q   +  F +T WP+ GVP     E  + F
Sbjct: 1752 YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP--KTGEGFIDF 1809

Query: 279  ---VHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSY 335
               VH  ++Q  +  GP+ +HCSAGVGRTG FI L  +L+ +R    VD+   V  +R+ 
Sbjct: 1810 IGQVHKTKEQFGQD-GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQ 1868

Query: 336  RMSMVQTEEQY 346
            R +MVQTE+QY
Sbjct: 1869 RPAMVQTEDQY 1879


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  225 bits (574), Expect = 4e-59
 Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)

Query: 10   VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 69
            VV  VLA++   +I +++  L+  RK+    +R+         +S+  + ++P +   + 
Sbjct: 1270 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 1318

Query: 70   LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
            ++ R+L           P+ + +   +I+ +  + + KFS ++E +   G       ++L
Sbjct: 1319 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 1377

Query: 121  PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
             +N+ KNRY N++ YD SRV L ++    G+DY+NANYI GY     YIATQG LPET  
Sbjct: 1378 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1437

Query: 181  DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
            DFW+M+ +Q+S  +VM+T+  E+ RVKCD YWP +     +G + V ++   E   +  R
Sbjct: 1438 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1496

Query: 241  HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 298
             F +  N + E ++V  F +TAWPDHGVP        L F+  V+       GPM++HCS
Sbjct: 1497 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1554

Query: 299  AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
            AGVGRTG FI +D +L+ I+  + VDI G V+ MR+ R  MVQTE+QYIFIH  +
Sbjct: 1555 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1609



 Score =  191 bits (484), Expect = 1e-48
 Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)

Query: 117  AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
            +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA++I GY   + YIATQGPL 
Sbjct: 1663 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1722

Query: 177  ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
            ET  DFW+M+ +  S I+VMLT+  E  R KC  YWP  E    Y    V+ ++E     
Sbjct: 1723 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1781

Query: 237  WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
            +  R F++  A + Q   V  F +T WP+ GVP   + E  + F   VH  ++Q  +  G
Sbjct: 1782 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1838

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
            P+ +HCSAGVGRTG FI L  +L+ +R    VDI   V  +R+ R +MVQTE+QY F ++
Sbjct: 1839 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1898


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  225 bits (574), Expect = 4e-59
 Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)

Query: 10   VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 69
            VV  VLA++   +I +++  L+  RK+    +R+         +S+  + ++P +   + 
Sbjct: 1257 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 1305

Query: 70   LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
            ++ R+L           P+ + +   +I+ +  + + KFS ++E +   G       ++L
Sbjct: 1306 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 1364

Query: 121  PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
             +N+ KNRY N++ YD SRV L ++    G+DY+NANYI GY     YIATQG LPET  
Sbjct: 1365 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1424

Query: 181  DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
            DFW+M+ +Q+S  +VM+T+  E+ RVKCD YWP +     +G + V ++   E   +  R
Sbjct: 1425 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1483

Query: 241  HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 298
             F +  N + E ++V  F +TAWPDHGVP        L F+  V+       GPM++HCS
Sbjct: 1484 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1541

Query: 299  AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
            AGVGRTG FI +D +L+ I+  + VDI G V+ MR+ R  MVQTE+QYIFIH  +
Sbjct: 1542 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1596



 Score =  191 bits (484), Expect = 1e-48
 Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)

Query: 117  AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
            +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA++I GY   + YIATQGPL 
Sbjct: 1650 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1709

Query: 177  ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
            ET  DFW+M+ +  S I+VMLT+  E  R KC  YWP  E    Y    V+ ++E     
Sbjct: 1710 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1768

Query: 237  WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
            +  R F++  A + Q   V  F +T WP+ GVP   + E  + F   VH  ++Q  +  G
Sbjct: 1769 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1825

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
            P+ +HCSAGVGRTG FI L  +L+ +R    VDI   V  +R+ R +MVQTE+QY F ++
Sbjct: 1826 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1885


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  225 bits (574), Expect = 4e-59
 Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)

Query: 10   VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 69
            VV  VLA++   +I +++  L+  RK+    +R+         +S+  + ++P +   + 
Sbjct: 1261 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 1309

Query: 70   LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
            ++ R+L           P+ + +   +I+ +  + + KFS ++E +   G       ++L
Sbjct: 1310 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 1368

Query: 121  PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
             +N+ KNRY N++ YD SRV L ++    G+DY+NANYI GY     YIATQG LPET  
Sbjct: 1369 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1428

Query: 181  DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
            DFW+M+ +Q+S  +VM+T+  E+ RVKCD YWP +     +G + V ++   E   +  R
Sbjct: 1429 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1487

Query: 241  HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 298
             F +  N + E ++V  F +TAWPDHGVP        L F+  V+       GPM++HCS
Sbjct: 1488 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1545

Query: 299  AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
            AGVGRTG FI +D +L+ I+  + VDI G V+ MR+ R  MVQTE+QYIFIH  +
Sbjct: 1546 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1600



 Score =  191 bits (484), Expect = 1e-48
 Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)

Query: 117  AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
            +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA++I GY   + YIATQGPL 
Sbjct: 1654 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1713

Query: 177  ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
            ET  DFW+M+ +  S I+VMLT+  E  R KC  YWP  E    Y    V+ ++E     
Sbjct: 1714 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1772

Query: 237  WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
            +  R F++  A + Q   V  F +T WP+ GVP   + E  + F   VH  ++Q  +  G
Sbjct: 1773 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1829

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
            P+ +HCSAGVGRTG FI L  +L+ +R    VDI   V  +R+ R +MVQTE+QY F ++
Sbjct: 1830 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1889


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score =  225 bits (574), Expect = 4e-59
 Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)

Query: 10   VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 69
            VV  VLA++   +I +++  L+  RK+    +R+         +S+  + ++P +   + 
Sbjct: 859  VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 907

Query: 70   LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
            ++ R+L           P+ + +   +I+ +  + + KFS ++E +   G       ++L
Sbjct: 908  VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 966

Query: 121  PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
             +N+ KNRY N++ YD SRV L ++    G+DY+NANYI GY     YIATQG LPET  
Sbjct: 967  EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1026

Query: 181  DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
            DFW+M+ +Q+S  +VM+T+  E+ RVKCD YWP +     +G + V ++   E   +  R
Sbjct: 1027 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1085

Query: 241  HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 298
             F +  N + E ++V  F +TAWPDHGVP        L F+  V+       GPM++HCS
Sbjct: 1086 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1143

Query: 299  AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
            AGVGRTG FI +D +L+ I+  + VDI G V+ MR+ R  MVQTE+QYIFIH  +
Sbjct: 1144 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1198



 Score =  191 bits (484), Expect = 1e-48
 Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)

Query: 117  AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
            +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA++I GY   + YIATQGPL 
Sbjct: 1252 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311

Query: 177  ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
            ET  DFW+M+ +  S I+VMLT+  E  R KC  YWP  E    Y    V+ ++E     
Sbjct: 1312 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1370

Query: 237  WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
            +  R F++  A + Q   V  F +T WP+ GVP   + E  + F   VH  ++Q  +  G
Sbjct: 1371 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1427

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
            P+ +HCSAGVGRTG FI L  +L+ +R    VDI   V  +R+ R +MVQTE+QY F ++
Sbjct: 1428 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1487


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  224 bits (571), Expect = 1e-58
 Identities = 124/348 (35%), Positives = 199/348 (57%), Gaps = 19/348 (5%)

Query: 17   ILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLT 76
            +L+ + I  +++ +++ + K  +   E  +      +S+  + ++P +   + ++ R+L 
Sbjct: 860  VLAVVFIICIVIAILLYKSKPDRKRAESDSRK----SSIPNNKEIPSHHPTDPVELRRLN 915

Query: 77   ---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKN 127
                      P+ + +   +I+ +  + + KFS ++E +   G       ++L +N+ KN
Sbjct: 916  FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKN 974

Query: 128  RYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVL 187
            RY N++ YD SRV L ++    G+DY+NANYI GY     YIATQG LPET  DFW+M+ 
Sbjct: 975  RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1034

Query: 188  QQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--N 245
            +Q+S  +VM+T+  E+ RVKCD YWP +     +G + V ++   E   +  R F +  N
Sbjct: 1035 EQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVRTFALYKN 1093

Query: 246  YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTG 305
             + E ++V  F +TAWPDHGVP        L F+  V+       GPM++HCSAGVGRTG
Sbjct: 1094 GSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1151

Query: 306  TFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
             FI +D +L+ I+  + VDI G V+ MR+ R  MVQTE+QYIFIH  +
Sbjct: 1152 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1199



 Score =  191 bits (484), Expect = 1e-48
 Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)

Query: 117  AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
            +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA++I GY   + YIATQGPL 
Sbjct: 1253 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1312

Query: 177  ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
            ET  DFW+M+ +  S I+VMLT+  E  R KC  YWP  E    Y    V+ ++E     
Sbjct: 1313 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1371

Query: 237  WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
            +  R F++  A + Q   V  F +T WP+ GVP   + E  + F   VH  ++Q  +  G
Sbjct: 1372 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1428

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
            P+ +HCSAGVGRTG FI L  +L+ +R    VDI   V  +R+ R +MVQTE+QY F ++
Sbjct: 1429 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1488


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  223 bits (569), Expect = 2e-58
 Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)

Query: 78   PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 137
            P+ + D   + + +  +   K S ++E +   G       ++L +N+ KNRY N++ YD 
Sbjct: 929  PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 987

Query: 138  SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 197
            SRV L  +    G+DYINANY+ GY     YIATQGPLPET  DFW+MV +Q+S  IVM+
Sbjct: 988  SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1047

Query: 198  TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 255
            T+  EK R+KCD YWP       YG I V ++   E   +  R F +  N + E ++V  
Sbjct: 1048 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1106

Query: 256  FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 315
            F +TAWPDHGVP        L F+  V+       GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1107 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1164

Query: 316  HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
             I+  + VD+ G V+ MRS R  MVQTE+QY FIH+ +
Sbjct: 1165 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1202



 Score =  191 bits (486), Expect = 7e-49
 Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)

Query: 117  AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
            +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA++I GY   + YIATQGPL 
Sbjct: 1256 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1315

Query: 177  ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
            ET  DFW+M+ +  S I+VMLT+  E  R KC  YWP  E    Y    V+ ++E     
Sbjct: 1316 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1374

Query: 237  WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
            +  R F++  A + Q   V  F +T WP+ GVP   + E  + F   VH  ++Q  +  G
Sbjct: 1375 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1431

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
            P+ +HCSAGVGRTG FI L  +L+ +R    VDI   V  +R+ R +MVQTE++Y F +Q
Sbjct: 1432 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1491


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  223 bits (569), Expect = 2e-58
 Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)

Query: 78   PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 137
            P+ + D   + + +  +   K S ++E +   G       ++L +N+ KNRY N++ YD 
Sbjct: 1334 PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 1392

Query: 138  SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 197
            SRV L  +    G+DYINANY+ GY     YIATQGPLPET  DFW+MV +Q+S  IVM+
Sbjct: 1393 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1452

Query: 198  TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 255
            T+  EK R+KCD YWP       YG I V ++   E   +  R F +  N + E ++V  
Sbjct: 1453 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1511

Query: 256  FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 315
            F +TAWPDHGVP        L F+  V+       GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1512 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1569

Query: 316  HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
             I+  + VD+ G V+ MRS R  MVQTE+QY FIH+ +
Sbjct: 1570 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1607



 Score =  191 bits (486), Expect = 7e-49
 Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)

Query: 117  AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
            +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA++I GY   + YIATQGPL 
Sbjct: 1661 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720

Query: 177  ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
            ET  DFW+M+ +  S I+VMLT+  E  R KC  YWP  E    Y    V+ ++E     
Sbjct: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1779

Query: 237  WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
            +  R F++  A + Q   V  F +T WP+ GVP   + E  + F   VH  ++Q  +  G
Sbjct: 1780 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1836

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
            P+ +HCSAGVGRTG FI L  +L+ +R    VDI   V  +R+ R +MVQTE++Y F +Q
Sbjct: 1837 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1896


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  223 bits (569), Expect = 2e-58
 Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)

Query: 78   PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 137
            P+ + D   + + +  +   K S ++E +   G       ++L +N+ KNRY N++ YD 
Sbjct: 925  PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 983

Query: 138  SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 197
            SRV L  +    G+DYINANY+ GY     YIATQGPLPET  DFW+MV +Q+S  IVM+
Sbjct: 984  SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1043

Query: 198  TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 255
            T+  EK R+KCD YWP       YG I V ++   E   +  R F +  N + E ++V  
Sbjct: 1044 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1102

Query: 256  FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 315
            F +TAWPDHGVP        L F+  V+       GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1103 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1160

Query: 316  HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
             I+  + VD+ G V+ MRS R  MVQTE+QY FIH+ +
Sbjct: 1161 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1198



 Score =  191 bits (486), Expect = 7e-49
 Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)

Query: 117  AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
            +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA++I GY   + YIATQGPL 
Sbjct: 1252 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311

Query: 177  ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
            ET  DFW+M+ +  S I+VMLT+  E  R KC  YWP  E    Y    V+ ++E     
Sbjct: 1312 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1370

Query: 237  WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
            +  R F++  A + Q   V  F +T WP+ GVP   + E  + F   VH  ++Q  +  G
Sbjct: 1371 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1427

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
            P+ +HCSAGVGRTG FI L  +L+ +R    VDI   V  +R+ R +MVQTE++Y F +Q
Sbjct: 1428 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1487


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  223 bits (569), Expect = 2e-58
 Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)

Query: 78   PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 137
            P+ + D   + + +  +   K S ++E +   G       ++L +N+ KNRY N++ YD 
Sbjct: 1372 PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 1430

Query: 138  SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 197
            SRV L  +    G+DYINANY+ GY     YIATQGPLPET  DFW+MV +Q+S  IVM+
Sbjct: 1431 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1490

Query: 198  TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 255
            T+  EK R+KCD YWP       YG I V ++   E   +  R F +  N + E ++V  
Sbjct: 1491 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1549

Query: 256  FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 315
            F +TAWPDHGVP        L F+  V+       GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1550 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1607

Query: 316  HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
             I+  + VD+ G V+ MRS R  MVQTE+QY FIH+ +
Sbjct: 1608 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1645



 Score =  191 bits (486), Expect = 7e-49
 Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)

Query: 117  AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
            +A+LP N+ KNR  NI+PY+ +RV L  +   EG+DYINA++I GY   + YIATQGPL 
Sbjct: 1699 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1758

Query: 177  ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
            ET  DFW+M+ +  S I+VMLT+  E  R KC  YWP  E    Y    V+ ++E     
Sbjct: 1759 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1817

Query: 237  WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
            +  R F++  A + Q   V  F +T WP+ GVP   + E  + F   VH  ++Q  +  G
Sbjct: 1818 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1874

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
            P+ +HCSAGVGRTG FI L  +L+ +R    VDI   V  +R+ R +MVQTE++Y F +Q
Sbjct: 1875 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1934


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  222 bits (566), Expect = 4e-58
 Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 7/277 (2%)

Query: 79   VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
            +++ D   +I  M +   Y F  ++E L   G       A    NR KNRY NI+ YD S
Sbjct: 869  IRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHS 927

Query: 139  RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
            RVRL+ ++ +  +DYINANYI GY+ P+ YIATQGP+ ET  DFW+M+ Q+ S  IVM+T
Sbjct: 928  RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 987

Query: 199  QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHF 256
               E  RVKC  YWP  ++   YGDI V +I  E   ++  R F +      E++++  F
Sbjct: 988  NLVEVGRVKCVRYWP--DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1045

Query: 257  NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 316
            ++T+WPDHGVP    A  +L FV  V+       GP+++HCSAG GRTG FIA+D +L  
Sbjct: 1046 HFTSWPDHGVPC--YATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1103

Query: 317  IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
              +   VDI   V E+R+ R+++VQTEEQY+F+H  +
Sbjct: 1104 AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1140



 Score =  128 bits (321), Expect = 1e-29
 Identities = 78/239 (32%), Positives = 125/239 (52%), Gaps = 12/239 (5%)

Query: 120  LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 179
            LP N  KNR  ++LP D     L+S+ + E ++YINA  +  +  P  ++ TQ PLP T 
Sbjct: 1199 LPRNHDKNRSMDVLPLDRCLPFLISV-DGESSNYINAALMDSHKQPAAFVVTQHPLPNTV 1257

Query: 180  NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWAC 239
             DFW++V       +VML + +  +   C  YWP  +    YG I VE +S +  +D   
Sbjct: 1258 ADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWP-EKTSGCYGPIQVEFVSADIDEDIIH 1314

Query: 240  RHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKGP 292
            R FRI      QD    V H  Y  WP +   T  +  S+L+ V  +   ++Q    +G 
Sbjct: 1315 RIFRICNMARPQDGYRIVQHLQYIGWPAYR-DTPPSKRSLLKVVRRLEKWQEQYDGREGR 1373

Query: 293  MIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
             ++HC  G GR+GTF A+  + + I+    +D+  +V  +R+ + +MV+T EQY F+++
Sbjct: 1374 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYE 1432


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  222 bits (566), Expect = 4e-58
 Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 7/277 (2%)

Query: 79   VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
            +++ D   +I  M +   Y F  ++E L   G       A    NR KNRY NI+ YD S
Sbjct: 888  IRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHS 946

Query: 139  RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
            RVRL+ ++ +  +DYINANYI GY+ P+ YIATQGP+ ET  DFW+M+ Q+ S  IVM+T
Sbjct: 947  RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 1006

Query: 199  QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHF 256
               E  RVKC  YWP  ++   YGDI V +I  E   ++  R F +      E++++  F
Sbjct: 1007 NLVEVGRVKCVRYWP--DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1064

Query: 257  NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 316
            ++T+WPDHGVP    A  +L FV  V+       GP+++HCSAG GRTG FIA+D +L  
Sbjct: 1065 HFTSWPDHGVPC--YATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1122

Query: 317  IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
              +   VDI   V E+R+ R+++VQTEEQY+F+H  +
Sbjct: 1123 AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159



 Score =  128 bits (321), Expect = 1e-29
 Identities = 78/239 (32%), Positives = 125/239 (52%), Gaps = 12/239 (5%)

Query: 120  LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 179
            LP N  KNR  ++LP D     L+S+ + E ++YINA  +  +  P  ++ TQ PLP T 
Sbjct: 1218 LPRNHDKNRSMDVLPLDRCLPFLISV-DGESSNYINAALMDSHKQPAAFVVTQHPLPNTV 1276

Query: 180  NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWAC 239
             DFW++V       +VML + +  +   C  YWP  +    YG I VE +S +  +D   
Sbjct: 1277 ADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWP-EKTSGCYGPIQVEFVSADIDEDIIH 1333

Query: 240  RHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKGP 292
            R FRI      QD    V H  Y  WP +   T  +  S+L+ V  +   ++Q    +G 
Sbjct: 1334 RIFRICNMARPQDGYRIVQHLQYIGWPAYR-DTPPSKRSLLKVVRRLEKWQEQYDGREGR 1392

Query: 293  MIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
             ++HC  G GR+GTF A+  + + I+    +D+  +V  +R+ + +MV+T EQY F+++
Sbjct: 1393 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYE 1451


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform
           3 precursor [Homo sapiens]
          Length = 1256

 Score =  220 bits (560), Expect = 2e-57
 Identities = 125/346 (36%), Positives = 188/346 (54%), Gaps = 19/346 (5%)

Query: 13  SVLAILSTLLIGLLLVTLIILRKKH-LQMARECGAGTFVNFASLERDGKLPYNWSKNGLK 71
           +++A L+ L+I   +  L++L K + L   R C          +ERD +          K
Sbjct: 528 ALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQEL--VERDDE----------K 575

Query: 72  KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 131
           +     P+  D      K    D    F  +F+ +  +    P   A  P N+ KNRY +
Sbjct: 576 QLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVD 635

Query: 132 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 191
           ILPYD++RV L  +N + G++YINA+YI G+  P++YIA QGP  ET +DFW+M+ +QK+
Sbjct: 636 ILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKA 695

Query: 192 QIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYADEM 250
            +IVM+T+C E  R KC  YWP  EE   A+GD+ V++   +   D+  +   I    E 
Sbjct: 696 TVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEK 755

Query: 251 ---QDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTF 307
              ++V H  +T+WPDHGVP       +L+    V   +    GP+++HCSAGVGRTGT+
Sbjct: 756 ATGREVTHIQFTSWPDHGVP--EDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTY 813

Query: 308 IALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
           I +D +L+ +     VD+ G V ++R  R  MVQ E QYI IHQ +
Sbjct: 814 IGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859



 Score =  140 bits (354), Expect = 1e-33
 Identities = 87/260 (33%), Positives = 129/260 (49%), Gaps = 31/260 (11%)

Query: 123  NRCKNRYTNILPYDFSRVRLV-------------------SMNEEEGADYINANYIPGYN 163
            N+ KNR +N++PYD++RV L                      + EE + YINA++I  Y 
Sbjct: 918  NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 977

Query: 164  SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGD 223
             P+  IA QGPL ET  DFW+M+ Q+K ++IVMLT+     +  C  YW   E    YGD
Sbjct: 978  KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW--GEGKQTYGD 1035

Query: 224  ITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVH 280
            I V++   ++   +  R F + ++   + + V  + YT W    +P       S++Q V 
Sbjct: 1036 IEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK 1095

Query: 281  MVRQQATKSKG-------PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMR 333
                Q   S+G       P++IHC  G  +TG F AL  LL+     E VDI  +V  +R
Sbjct: 1096 QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALR 1155

Query: 334  SYRMSMVQTEEQYIFIHQCV 353
              R  MV T EQY F++  +
Sbjct: 1156 KARPGMVSTFEQYQFLYDVI 1175


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform
           1 precursor [Homo sapiens]
          Length = 1304

 Score =  220 bits (560), Expect = 2e-57
 Identities = 125/346 (36%), Positives = 188/346 (54%), Gaps = 19/346 (5%)

Query: 13  SVLAILSTLLIGLLLVTLIILRKKH-LQMARECGAGTFVNFASLERDGKLPYNWSKNGLK 71
           +++A L+ L+I   +  L++L K + L   R C          +ERD +          K
Sbjct: 576 ALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQEL--VERDDE----------K 623

Query: 72  KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 131
           +     P+  D      K    D    F  +F+ +  +    P   A  P N+ KNRY +
Sbjct: 624 QLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVD 683

Query: 132 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 191
           ILPYD++RV L  +N + G++YINA+YI G+  P++YIA QGP  ET +DFW+M+ +QK+
Sbjct: 684 ILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKA 743

Query: 192 QIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYADEM 250
            +IVM+T+C E  R KC  YWP  EE   A+GD+ V++   +   D+  +   I    E 
Sbjct: 744 TVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEK 803

Query: 251 ---QDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTF 307
              ++V H  +T+WPDHGVP       +L+    V   +    GP+++HCSAGVGRTGT+
Sbjct: 804 ATGREVTHIQFTSWPDHGVP--EDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTY 861

Query: 308 IALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
           I +D +L+ +     VD+ G V ++R  R  MVQ E QYI IHQ +
Sbjct: 862 IGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907



 Score =  140 bits (354), Expect = 1e-33
 Identities = 87/260 (33%), Positives = 129/260 (49%), Gaps = 31/260 (11%)

Query: 123  NRCKNRYTNILPYDFSRVRLV-------------------SMNEEEGADYINANYIPGYN 163
            N+ KNR +N++PYD++RV L                      + EE + YINA++I  Y 
Sbjct: 966  NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 1025

Query: 164  SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGD 223
             P+  IA QGPL ET  DFW+M+ Q+K ++IVMLT+     +  C  YW   E    YGD
Sbjct: 1026 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW--GEGKQTYGD 1083

Query: 224  ITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVH 280
            I V++   ++   +  R F + ++   + + V  + YT W    +P       S++Q V 
Sbjct: 1084 IEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK 1143

Query: 281  MVRQQATKSKG-------PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMR 333
                Q   S+G       P++IHC  G  +TG F AL  LL+     E VDI  +V  +R
Sbjct: 1144 QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALR 1203

Query: 334  SYRMSMVQTEEQYIFIHQCV 353
              R  MV T EQY F++  +
Sbjct: 1204 KARPGMVSTFEQYQFLYDVI 1223


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform
           2 precursor [Homo sapiens]
          Length = 1143

 Score =  220 bits (560), Expect = 2e-57
 Identities = 125/346 (36%), Positives = 188/346 (54%), Gaps = 19/346 (5%)

Query: 13  SVLAILSTLLIGLLLVTLIILRKKH-LQMARECGAGTFVNFASLERDGKLPYNWSKNGLK 71
           +++A L+ L+I   +  L++L K + L   R C          +ERD +          K
Sbjct: 415 ALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQEL--VERDDE----------K 462

Query: 72  KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 131
           +     P+  D      K    D    F  +F+ +  +    P   A  P N+ KNRY +
Sbjct: 463 QLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVD 522

Query: 132 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 191
           ILPYD++RV L  +N + G++YINA+YI G+  P++YIA QGP  ET +DFW+M+ +QK+
Sbjct: 523 ILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKA 582

Query: 192 QIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYADEM 250
            +IVM+T+C E  R KC  YWP  EE   A+GD+ V++   +   D+  +   I    E 
Sbjct: 583 TVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEK 642

Query: 251 ---QDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTF 307
              ++V H  +T+WPDHGVP       +L+    V   +    GP+++HCSAGVGRTGT+
Sbjct: 643 ATGREVTHIQFTSWPDHGVP--EDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTY 700

Query: 308 IALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
           I +D +L+ +     VD+ G V ++R  R  MVQ E QYI IHQ +
Sbjct: 701 IGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746



 Score =  140 bits (354), Expect = 1e-33
 Identities = 87/260 (33%), Positives = 129/260 (49%), Gaps = 31/260 (11%)

Query: 123  NRCKNRYTNILPYDFSRVRLV-------------------SMNEEEGADYINANYIPGYN 163
            N+ KNR +N++PYD++RV L                      + EE + YINA++I  Y 
Sbjct: 805  NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 864

Query: 164  SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGD 223
             P+  IA QGPL ET  DFW+M+ Q+K ++IVMLT+     +  C  YW   E    YGD
Sbjct: 865  KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW--GEGKQTYGD 922

Query: 224  ITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVH 280
            I V++   ++   +  R F + ++   + + V  + YT W    +P       S++Q V 
Sbjct: 923  IEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK 982

Query: 281  MVRQQATKSKG-------PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMR 333
                Q   S+G       P++IHC  G  +TG F AL  LL+     E VDI  +V  +R
Sbjct: 983  QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALR 1042

Query: 334  SYRMSMVQTEEQYIFIHQCV 353
              R  MV T EQY F++  +
Sbjct: 1043 KARPGMVSTFEQYQFLYDVI 1062


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  219 bits (558), Expect = 3e-57
 Identities = 117/277 (42%), Positives = 162/277 (58%), Gaps = 7/277 (2%)

Query: 79   VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
            +++ D   +I  M     Y F  ++E     G   P  +A    NR KNRY NI+ YD S
Sbjct: 880  IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 938

Query: 139  RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
            RVRL ++  +  +DYIN NYI GY+ P  YIATQGP+ ET  DFW+MV  + +  I+M+T
Sbjct: 939  RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 998

Query: 199  QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHF 256
               E  RVKC  YWP  ++   Y DI V +I  E   ++  R F +      E++++  F
Sbjct: 999  NLVEVGRVKCCKYWP--DDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQF 1056

Query: 257  NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 316
            ++T WPDHGVP    A  +L FV  V+ ++  S GP+++HCSAG GRTG FI +D +L  
Sbjct: 1057 HFTGWPDHGVP--YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1114

Query: 317  IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
                  VDI   V E+RS R++MVQTEEQY+FIH  +
Sbjct: 1115 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1151



 Score =  122 bits (306), Expect = 5e-28
 Identities = 79/240 (32%), Positives = 123/240 (51%), Gaps = 14/240 (5%)

Query: 120  LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 179
            LP N  KNR  +ILP D     L+++ + E ++YINA  +  Y  P  +I TQ PLP T 
Sbjct: 1210 LPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTV 1268

Query: 180  NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWA 238
             DFW++VL      +VML   +  +   C  YWP  E  +  +G I VE +S + ++D  
Sbjct: 1269 KDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWP--ENGVHRHGPIQVEFVSADLEEDII 1324

Query: 239  CRHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKG 291
             R FRI  A   QD    V  F +  WP +   T  +  S L+ +  V   +++    +G
Sbjct: 1325 SRIFRIYNAARPQDGYRMVQQFQFLGWPMYR-DTPVSKRSFLKLIRQVDKWQEEYNGGEG 1383

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
              ++HC  G GR+GTF A+  + + +R    VD+   V  +R+ + +MV   +QY F ++
Sbjct: 1384 RTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYE 1443


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  219 bits (558), Expect = 3e-57
 Identities = 117/277 (42%), Positives = 162/277 (58%), Gaps = 7/277 (2%)

Query: 79   VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
            +++ D   +I  M     Y F  ++E     G   P  +A    NR KNRY NI+ YD S
Sbjct: 893  IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 951

Query: 139  RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
            RVRL ++  +  +DYIN NYI GY+ P  YIATQGP+ ET  DFW+MV  + +  I+M+T
Sbjct: 952  RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 1011

Query: 199  QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHF 256
               E  RVKC  YWP  ++   Y DI V +I  E   ++  R F +      E++++  F
Sbjct: 1012 NLVEVGRVKCCKYWP--DDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQF 1069

Query: 257  NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 316
            ++T WPDHGVP    A  +L FV  V+ ++  S GP+++HCSAG GRTG FI +D +L  
Sbjct: 1070 HFTGWPDHGVP--YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1127

Query: 317  IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
                  VDI   V E+RS R++MVQTEEQY+FIH  +
Sbjct: 1128 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1164



 Score =  122 bits (306), Expect = 5e-28
 Identities = 79/240 (32%), Positives = 123/240 (51%), Gaps = 14/240 (5%)

Query: 120  LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 179
            LP N  KNR  +ILP D     L+++ + E ++YINA  +  Y  P  +I TQ PLP T 
Sbjct: 1223 LPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTV 1281

Query: 180  NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWA 238
             DFW++VL      +VML   +  +   C  YWP  E  +  +G I VE +S + ++D  
Sbjct: 1282 KDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWP--ENGVHRHGPIQVEFVSADLEEDII 1337

Query: 239  CRHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKG 291
             R FRI  A   QD    V  F +  WP +   T  +  S L+ +  V   +++    +G
Sbjct: 1338 SRIFRIYNAARPQDGYRMVQQFQFLGWPMYR-DTPVSKRSFLKLIRQVDKWQEEYNGGEG 1396

Query: 292  PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
              ++HC  G GR+GTF A+  + + +R    VD+   V  +R+ + +MV   +QY F ++
Sbjct: 1397 RTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYE 1456


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,694,082
Number of Sequences: 37866
Number of extensions: 582026
Number of successful extensions: 1800
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 1309
Number of HSP's gapped (non-prelim): 172
length of query: 377
length of database: 18,247,518
effective HSP length: 104
effective length of query: 273
effective length of database: 14,309,454
effective search space: 3906480942
effective search space used: 3906480942
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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