Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 57242761
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57242761 receptor (TNFRSF)-interacting serine-threonine
kinase 1 [Homo sapiens]
(671 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 1370 0.0
gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo... 141 2e-33
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 136 7e-32
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ... 132 8e-31
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 127 3e-29
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 122 1e-27
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 122 1e-27
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 122 1e-27
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 121 2e-27
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 121 2e-27
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 119 7e-27
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 119 1e-26
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 119 1e-26
gi|187475373 c-src tyrosine kinase [Homo sapiens] 116 8e-26
gi|4758078 c-src tyrosine kinase [Homo sapiens] 116 8e-26
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 115 1e-25
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 114 2e-25
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 114 2e-25
gi|110349799 testis-specific protein kinase 2 [Homo sapiens] 113 6e-25
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 110 3e-24
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 110 3e-24
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 110 3e-24
gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens] 110 4e-24
gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens] 110 4e-24
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 109 9e-24
gi|4505001 LIM domain kinase 1 [Homo sapiens] 108 1e-23
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 108 2e-23
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 107 4e-23
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 107 5e-23
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 107 5e-23
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 1370 bits (3545), Expect = 0.0
Identities = 671/671 (100%), Positives = 671/671 (100%)
Query: 1 MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL 60
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
Sbjct: 1 MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL 60
Query: 61 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL 120
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
Sbjct: 61 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL 120
Query: 121 EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD 180
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
Sbjct: 121 EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD 180
Query: 181 GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC 240
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
Sbjct: 181 GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC 240
Query: 241 IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED 300
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
Sbjct: 241 IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED 300
Query: 301 VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA 360
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
Sbjct: 301 VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA 360
Query: 361 PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF 420
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
Sbjct: 361 PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF 420
Query: 421 AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD 480
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
Sbjct: 421 AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD 480
Query: 481 PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ 540
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
Sbjct: 481 PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ 540
Query: 541 IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN 600
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
Sbjct: 541 IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN 600
Query: 601 CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID 660
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
Sbjct: 601 CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID 660
Query: 661 LLSSLIYVSQN 671
LLSSLIYVSQN
Sbjct: 661 LLSSLIYVSQN 671
>gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo
sapiens]
Length = 518
Score = 141 bits (356), Expect = 2e-33
Identities = 101/299 (33%), Positives = 160/299 (53%), Gaps = 53/299 (17%)
Query: 14 SSDFLESAEL-DSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRH 72
S + LE+ EL GGFG V HR G Y I +++A+ E K M L +
Sbjct: 17 SIEELENQELVGKGGFGTVFRAQHRKWG-------YDVAVKIVNSKAISREVKAMASLDN 69
Query: 73 SRVVKLLGVII-----EEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMC 127
V++L GVI ++ K +LV ++ME G+L +L+++ P + R++ E++ GM
Sbjct: 70 EFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMF 129
Query: 128 YLHGKG--VIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAK- 184
YLH + ++H+DLKP N+L+D + H+K+AD GL++F+ S+ GT
Sbjct: 130 YLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ------------SGTGSG 177
Query: 185 KNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKE---PYE-----NAICEQQ 236
+ GGTL Y+APE +VN K + SDVYSF +++WA+ A +E P E A+C +Q
Sbjct: 178 EPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQ 237
Query: 237 LIMCIKSGNRPDVDDITEYCPRE-----IISLMKLCWEANPEARPTF----PGIEEKFR 286
NRP + ++ + P + LM+LCW + P+ RP+F P +E F+
Sbjct: 238 --------NRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ 288
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 136 bits (342), Expect = 7e-32
Identities = 113/372 (30%), Positives = 180/372 (48%), Gaps = 35/372 (9%)
Query: 14 SSDFLESAELDSGGFGKVSLC--FHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLR 71
+ +F ++ SGGFG+V H L I + + E E LLEEAK M +
Sbjct: 19 AGEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERME-LLEEAKKMEMAK 77
Query: 72 HSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLH- 130
++ + G+ E LVMEYME G+L +L +E P ++ RII E GM +LH
Sbjct: 78 FRYILPVYGICREP--VGLVMEYMETGSLEKLLASE-PLPWDLRFRIIHETAVGMNFLHC 134
Query: 131 -GKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGT 189
++H DLKP NIL+D +H+KI+D GLA K N H+ +DG GT
Sbjct: 135 MAPPLLHLDLKPANILLDAHYHVKISDFGLA------KCNGLSHSHDLSMDGLF----GT 184
Query: 190 LYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDV 249
+ Y+ PE + + + K DVYSFA+V+W + K+P+ + +++ + G+RP++
Sbjct: 185 IAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPEL 244
Query: 250 DDITEYCPR---EIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKK 306
+ PR +I LM+ CW+ +P RPTF I + L E +++VK
Sbjct: 245 PPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQEITSE-----TEDLCEKPDDEVKETAH 299
Query: 307 EYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHP 366
+ VK + + V R+++ T S+ L +S + ++E P
Sbjct: 300 DLD-----VKSPPEPRSEVVPARLKRASAPTFD-NDYSLSELLSQ---LDSGVSQAVEGP 350
Query: 367 QEENEPSLQSKL 378
+E + S +SKL
Sbjct: 351 EELSRSSSESKL 362
>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
sapiens]
Length = 540
Score = 132 bits (333), Expect = 8e-31
Identities = 84/259 (32%), Positives = 140/259 (54%), Gaps = 22/259 (8%)
Query: 60 LLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTP---LSVKG 116
+L EA+++++ R S ++ +LG+ E +V EYM G+L +L + P ++
Sbjct: 63 VLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRF 122
Query: 117 RIILEIIEGMCYLHGKG--VIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHN 174
RI+ EI G+ YLH ++H DLK +NIL+DN+FH+KIAD GL+ ++M S +
Sbjct: 123 RILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSK 182
Query: 175 ELREVDGTAKKNGGTLYYMAPEHLN-DVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIC 233
E GGT+ YM PE+ ++ + K D+YS+AV+ W + + K+P+E+
Sbjct: 183 SAPE--------GGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTN 234
Query: 234 EQQLIMCIKSGNRPDVDDITEYCPREI------ISLMKLCWEANPEARPTFPGIEEKFRP 287
Q++ + G+RP +++ E P +I ISL++ W NP+ RP+F + P
Sbjct: 235 PLQIMYSVSQGHRPVINE--ESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEP 292
Query: 288 FYLSQLEESVEEDVKSLKK 306
+ E + E V LKK
Sbjct: 293 VLRTFEEITFLEAVIQLKK 311
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 127 bits (319), Expect = 3e-29
Identities = 87/267 (32%), Positives = 140/267 (52%), Gaps = 31/267 (11%)
Query: 25 SGGFGKVSLCFHRTQGLMIMKTVY--KGPNCIEHNEA------LLEEAKMMNRLRHSRVV 76
SGGF +V HR +T Y K C+ + A L+EEA M +++ +V
Sbjct: 30 SGGFSQVFQARHRR-----WRTEYAIKCAPCLPPDAASSDVNYLIEEAAKMKKIKFQHIV 84
Query: 77 KLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHG--KGV 134
+ GV + +VME+M G+L VL S ++ RII E M +LH +
Sbjct: 85 SIYGVCKQP--LGIVMEFMANGSLEKVLSTH-SLCWKLRFRIIHETSLAMNFLHSIKPPL 141
Query: 135 IHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMA 194
+H DLKP NIL+D++ H+KI+D GL+ + E+ ++ ++ +A + G L Y+
Sbjct: 142 LHLDLKPGNILLDSNMHVKISDFGLSKWM-------EQSTRMQYIERSALR--GMLSYIP 192
Query: 195 PEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITE 254
PE + N P K DVYSFA+V+W + K+PY + +I+ + +G RP + +++
Sbjct: 193 PEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPY-SGFNMMMIIIRVAAGMRPSLQPVSD 251
Query: 255 YCPRE---IISLMKLCWEANPEARPTF 278
P E ++ LMK CW+ +P+ RP F
Sbjct: 252 QWPSEAQQMVDLMKRCWDQDPKKRPCF 278
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 122 bits (306), Expect = 1e-27
Identities = 88/268 (32%), Positives = 136/268 (50%), Gaps = 33/268 (12%)
Query: 21 AELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLL 79
A++ G FG V QG + K K C +A L+E +M +++H +V+LL
Sbjct: 198 AQIGEGEFGAV------LQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLL 251
Query: 80 GVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKG--RIILEIIEGMCYLHGKGVIHK 137
GVI+ +G Y +VME++ KGNL++ L+ ++ + L + EGM YL K ++H+
Sbjct: 252 GVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHR 310
Query: 138 DLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEH 197
DL NILV D K++D GLA E + +D + + + APE
Sbjct: 311 DLAARNILVSEDLVAKVSDFGLAK------------AERKGLDSSRL----PVKWTAPEA 354
Query: 198 LNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYC 256
L + K T KSDV+SF V+LW +F+ + PY + +++ ++ G R + E C
Sbjct: 355 LK--HGKFTSKSDVWSFGVLLWEVFSYGRAPYPK-MSLKEVSEAVEKGYRMEP---PEGC 408
Query: 257 PREIISLMKLCWEANPEARPTFPGIEEK 284
P + LM CWEA P RP F + EK
Sbjct: 409 PGPVHVLMSSCWEAEPARRPPFRKLAEK 436
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 122 bits (306), Expect = 1e-27
Identities = 88/268 (32%), Positives = 136/268 (50%), Gaps = 33/268 (12%)
Query: 21 AELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLL 79
A++ G FG V QG + K K C +A L+E +M +++H +V+LL
Sbjct: 240 AQIGEGEFGAV------LQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLL 293
Query: 80 GVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKG--RIILEIIEGMCYLHGKGVIHK 137
GVI+ +G Y +VME++ KGNL++ L+ ++ + L + EGM YL K ++H+
Sbjct: 294 GVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHR 352
Query: 138 DLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEH 197
DL NILV D K++D GLA E + +D + + + APE
Sbjct: 353 DLAARNILVSEDLVAKVSDFGLAK------------AERKGLDSSRL----PVKWTAPEA 396
Query: 198 LNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYC 256
L + K T KSDV+SF V+LW +F+ + PY + +++ ++ G R + E C
Sbjct: 397 LK--HGKFTSKSDVWSFGVLLWEVFSYGRAPYPK-MSLKEVSEAVEKGYRMEP---PEGC 450
Query: 257 PREIISLMKLCWEANPEARPTFPGIEEK 284
P + LM CWEA P RP F + EK
Sbjct: 451 PGPVHVLMSSCWEAEPARRPPFRKLAEK 478
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 122 bits (306), Expect = 1e-27
Identities = 88/268 (32%), Positives = 136/268 (50%), Gaps = 33/268 (12%)
Query: 21 AELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLL 79
A++ G FG V QG + K K C +A L+E +M +++H +V+LL
Sbjct: 239 AQIGEGEFGAV------LQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLL 292
Query: 80 GVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKG--RIILEIIEGMCYLHGKGVIHK 137
GVI+ +G Y +VME++ KGNL++ L+ ++ + L + EGM YL K ++H+
Sbjct: 293 GVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHR 351
Query: 138 DLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEH 197
DL NILV D K++D GLA E + +D + + + APE
Sbjct: 352 DLAARNILVSEDLVAKVSDFGLAK------------AERKGLDSSRL----PVKWTAPEA 395
Query: 198 LNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYC 256
L + K T KSDV+SF V+LW +F+ + PY + +++ ++ G R + E C
Sbjct: 396 LK--HGKFTSKSDVWSFGVLLWEVFSYGRAPYPK-MSLKEVSEAVEKGYRMEP---PEGC 449
Query: 257 PREIISLMKLCWEANPEARPTFPGIEEK 284
P + LM CWEA P RP F + EK
Sbjct: 450 PGPVHVLMSSCWEAEPARRPPFRKLAEK 477
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 121 bits (304), Expect = 2e-27
Identities = 87/276 (31%), Positives = 133/276 (48%), Gaps = 36/276 (13%)
Query: 23 LDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVI 82
L +G FG+V + ++ + +KT+ G ++ A LEEA +M L+H ++V+L V+
Sbjct: 232 LGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQ---AFLEEANLMKTLQHDKLVRLYAVV 288
Query: 83 IEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL--------EIIEGMCYLHGKGV 134
E ++ EYM KG+L+ LK++ G+++L +I EGM Y+ K
Sbjct: 289 TREEPIYIITEYMAKGSLLDFLKSDEG------GKVLLPKLIDFSAQIAEGMAYIERKNY 342
Query: 135 IHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMA 194
IH+DL+ N+LV KIAD GLA E NE +G + + A
Sbjct: 343 IHRDLRAANVLVSESLMCKIADFGLARV--------IEDNEYTAREGAK----FPIKWTA 390
Query: 195 PEHLNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDIT 253
PE +N T KSDV+SF ++L+ I K PY + + P V
Sbjct: 391 PEAIN--FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV---- 444
Query: 254 EYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFY 289
E CP E+ +MK+CW+ E RPTF ++ FY
Sbjct: 445 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY 480
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 121 bits (304), Expect = 2e-27
Identities = 87/276 (31%), Positives = 133/276 (48%), Gaps = 36/276 (13%)
Query: 23 LDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVI 82
L +G FG+V + ++ + +KT+ G ++ A LEEA +M L+H ++V+L V+
Sbjct: 253 LGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQ---AFLEEANLMKTLQHDKLVRLYAVV 309
Query: 83 IEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL--------EIIEGMCYLHGKGV 134
E ++ EYM KG+L+ LK++ G+++L +I EGM Y+ K
Sbjct: 310 TREEPIYIITEYMAKGSLLDFLKSDEG------GKVLLPKLIDFSAQIAEGMAYIERKNY 363
Query: 135 IHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMA 194
IH+DL+ N+LV KIAD GLA E NE +G + + A
Sbjct: 364 IHRDLRAANVLVSESLMCKIADFGLARV--------IEDNEYTAREGAK----FPIKWTA 411
Query: 195 PEHLNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDIT 253
PE +N T KSDV+SF ++L+ I K PY + + P V
Sbjct: 412 PEAIN--FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV---- 465
Query: 254 EYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFY 289
E CP E+ +MK+CW+ E RPTF ++ FY
Sbjct: 466 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY 501
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 119 bits (299), Expect = 7e-27
Identities = 106/357 (29%), Positives = 164/357 (45%), Gaps = 52/357 (14%)
Query: 20 SAELDSGGFGKV------SLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHS 73
S EL G FG V + + + +KTV + + E E L EA +M
Sbjct: 1002 SRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIE-FLNEASVMKEFNCH 1060
Query: 74 RVVKLLGVIIEEGKYSLVMEYMEKGNL---MHVLKAEMST-----PLSVKGRIIL--EII 123
VV+LLGV+ + ++ME M +G+L + L+ EM P S+ I + EI
Sbjct: 1061 HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIA 1120
Query: 124 EGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTA 183
+GM YL+ +H+DL N +V DF +KI D G+ ++ E D
Sbjct: 1121 DGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMT-------------RDIYETDYYR 1167
Query: 184 KKNGGTL--YYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMC 240
K G L +M+PE L D T SDV+SF VVLW I ++PY+ EQ L
Sbjct: 1168 KGGKGLLPVRWMSPESLKD--GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 1225
Query: 241 IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED 300
++ G + D + CP + LM++CW+ NP+ RP+F I +S ++E +E
Sbjct: 1226 MEGG----LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI--------ISSIKEEMEPG 1273
Query: 301 VKSLKKEYSNENAVVK----RMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGP 353
+ + YS EN + + ++ ++ V + S S+S+ P HS GP
Sbjct: 1274 FREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLP-DRHSGHKAENGP 1329
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 119 bits (297), Expect = 1e-26
Identities = 84/269 (31%), Positives = 135/269 (50%), Gaps = 23/269 (8%)
Query: 23 LDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVI 82
L +G FG+V + ++ + +K++ +G +A L EA +M +L+H R+V+L V+
Sbjct: 251 LGAGQFGEVWMGYYNGHTKVAVKSLKQGSMS---PDAFLAEANLMKQLQHQRLVRLYAVV 307
Query: 83 IEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL--EIIEGMCYLHGKGVIHKDLK 140
+E Y ++ EYME G+L+ LK L++ + + +I EGM ++ + IH+DL+
Sbjct: 308 TQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLR 366
Query: 141 PENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLND 200
NILV + KIAD GLA E NE +G + + APE +N
Sbjct: 367 AANILVSDTLSCKIADFGLARL--------IEDNEYTAREGAK----FPIKWTAPEAIN- 413
Query: 201 VNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREI 260
T KSDV+SF ++L I + + ++I ++ G R D CP E+
Sbjct: 414 -YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPD---NCPEEL 469
Query: 261 ISLMKLCWEANPEARPTFPGIEEKFRPFY 289
LM+LCW+ PE RPTF + F+
Sbjct: 470 YQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 119 bits (297), Expect = 1e-26
Identities = 84/269 (31%), Positives = 135/269 (50%), Gaps = 23/269 (8%)
Query: 23 LDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVI 82
L +G FG+V + ++ + +K++ +G +A L EA +M +L+H R+V+L V+
Sbjct: 251 LGAGQFGEVWMGYYNGHTKVAVKSLKQGSMS---PDAFLAEANLMKQLQHQRLVRLYAVV 307
Query: 83 IEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL--EIIEGMCYLHGKGVIHKDLK 140
+E Y ++ EYME G+L+ LK L++ + + +I EGM ++ + IH+DL+
Sbjct: 308 TQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLR 366
Query: 141 PENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLND 200
NILV + KIAD GLA E NE +G + + APE +N
Sbjct: 367 AANILVSDTLSCKIADFGLARL--------IEDNEYTAREGAK----FPIKWTAPEAIN- 413
Query: 201 VNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREI 260
T KSDV+SF ++L I + + ++I ++ G R D CP E+
Sbjct: 414 -YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPD---NCPEEL 469
Query: 261 ISLMKLCWEANPEARPTFPGIEEKFRPFY 289
LM+LCW+ PE RPTF + F+
Sbjct: 470 YQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 116 bits (290), Expect = 8e-26
Identities = 90/285 (31%), Positives = 141/285 (49%), Gaps = 45/285 (15%)
Query: 10 IKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHN---EALLEEAKM 66
+ MK L++ + G FG V L +R + + CI+++ +A L EA +
Sbjct: 190 LNMKELKLLQT--IGKGEFGDVMLGDYRGNKVAV--------KCIKNDATAQAFLAEASV 239
Query: 67 MNRLRHSRVVKLLGVIIEE-GKYSLVMEYMEKGNLMHVLKAEMSTPLSVKG-----RIIL 120
M +LRHS +V+LLGVI+EE G +V EYM KG+L+ L+ S SV G + L
Sbjct: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR---SRGRSVLGGDCLLKFSL 296
Query: 121 EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD 180
++ E M YL G +H+DL N+LV D K++D GL +E
Sbjct: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT----------------KEAS 340
Query: 181 GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIM 239
T + + APE L + K + KSDV+SF ++LW I++ + PY I + ++
Sbjct: 341 STQDTGKLPVKWTAPEALRE--KKFSTKSDVWSFGILLWEIYSFGRVPYPR-IPLKDVVP 397
Query: 240 CIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEK 284
++ G + D D CP + +MK CW + RP+F + E+
Sbjct: 398 RVEKGYKMDAPD---GCPPAVYEVMKNCWHLDAAMRPSFLQLREQ 439
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 116 bits (290), Expect = 8e-26
Identities = 90/285 (31%), Positives = 141/285 (49%), Gaps = 45/285 (15%)
Query: 10 IKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHN---EALLEEAKM 66
+ MK L++ + G FG V L +R + + CI+++ +A L EA +
Sbjct: 190 LNMKELKLLQT--IGKGEFGDVMLGDYRGNKVAV--------KCIKNDATAQAFLAEASV 239
Query: 67 MNRLRHSRVVKLLGVIIEE-GKYSLVMEYMEKGNLMHVLKAEMSTPLSVKG-----RIIL 120
M +LRHS +V+LLGVI+EE G +V EYM KG+L+ L+ S SV G + L
Sbjct: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR---SRGRSVLGGDCLLKFSL 296
Query: 121 EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD 180
++ E M YL G +H+DL N+LV D K++D GL +E
Sbjct: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT----------------KEAS 340
Query: 181 GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIM 239
T + + APE L + K + KSDV+SF ++LW I++ + PY I + ++
Sbjct: 341 STQDTGKLPVKWTAPEALRE--KKFSTKSDVWSFGILLWEIYSFGRVPYPR-IPLKDVVP 397
Query: 240 CIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEK 284
++ G + D D CP + +MK CW + RP+F + E+
Sbjct: 398 RVEKGYKMDAPD---GCPPAVYEVMKNCWHLDAAMRPSFLQLREQ 439
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 115 bits (289), Expect = 1e-25
Identities = 88/271 (32%), Positives = 135/271 (49%), Gaps = 25/271 (9%)
Query: 22 ELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGV 81
+L +G FG+V + + + +KT+ G +E A L EA +M L+H ++VKL V
Sbjct: 267 KLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE---AFLAEANVMKTLQHDKLVKLHAV 323
Query: 82 IIEEGKYSLVMEYMEKGNLMHVLKAEMST--PLSVKGRIILEIIEGMCYLHGKGVIHKDL 139
+ +E Y ++ E+M KG+L+ LK++ + PL +I EGM ++ + IH+DL
Sbjct: 324 VTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDL 382
Query: 140 KPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLN 199
+ NILV KIAD GLA E NE +G + + APE +N
Sbjct: 383 RAANILVSASLVCKIADFGLARV--------IEDNEYTAREGAK----FPIKWTAPEAIN 430
Query: 200 DVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPR 258
T KSDV+SF ++L I + PY + ++I ++ G R E CP
Sbjct: 431 --FGSFTIKSDVWSFGILLMEIVTYGRIPYP-GMSNPEVIRALERGYRM---PRPENCPE 484
Query: 259 EIISLMKLCWEANPEARPTFPGIEEKFRPFY 289
E+ ++M CW+ PE RPTF I+ FY
Sbjct: 485 ELYNIMMRCWKNRPEERPTFEYIQSVLDDFY 515
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 114 bits (286), Expect = 2e-25
Identities = 103/353 (29%), Positives = 154/353 (43%), Gaps = 54/353 (15%)
Query: 22 ELDSGGFGKV------SLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRV 75
EL G FG V + + + +KTV + + E E L EA +M V
Sbjct: 1016 ELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIE-FLNEASVMKGFTCHHV 1074
Query: 76 VKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGR----------IILEIIEG 125
V+LLGV+ + +VME M G+L L++ + GR + EI +G
Sbjct: 1075 VRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG 1134
Query: 126 MCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKK 185
M YL+ K +H+DL N +V +DF +KI D G+ ++ E D K
Sbjct: 1135 MAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMT-------------RDIYETDYYRKG 1181
Query: 186 NGGTL--YYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKS 243
G L +MAPE L D T SD++SF VVLW I + E + +Q++ +
Sbjct: 1182 GKGLLPVRWMAPESLKD--GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD 1239
Query: 244 GNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKS 303
G D D CP + LM++CW+ NP+ RPTF I ++ L++ +
Sbjct: 1240 GGYLDQPD---NCPERVTDLMRMCWQFNPKMRPTFLEI--------VNLLKDDLHPSFPE 1288
Query: 304 LKKEYSNENAVVKRMQSLQL-----DCVAVPSSRSNSA-TEQPGSLHSSQGLG 350
+ +S EN K +S +L D VP RS+ E+ G LG
Sbjct: 1289 VSFFHSEEN---KAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLG 1338
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 114 bits (286), Expect = 2e-25
Identities = 103/353 (29%), Positives = 154/353 (43%), Gaps = 54/353 (15%)
Query: 22 ELDSGGFGKV------SLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRV 75
EL G FG V + + + +KTV + + E E L EA +M V
Sbjct: 1028 ELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIE-FLNEASVMKGFTCHHV 1086
Query: 76 VKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGR----------IILEIIEG 125
V+LLGV+ + +VME M G+L L++ + GR + EI +G
Sbjct: 1087 VRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG 1146
Query: 126 MCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKK 185
M YL+ K +H+DL N +V +DF +KI D G+ ++ E D K
Sbjct: 1147 MAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMT-------------RDIYETDYYRKG 1193
Query: 186 NGGTL--YYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKS 243
G L +MAPE L D T SD++SF VVLW I + E + +Q++ +
Sbjct: 1194 GKGLLPVRWMAPESLKD--GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD 1251
Query: 244 GNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKS 303
G D D CP + LM++CW+ NP+ RPTF I ++ L++ +
Sbjct: 1252 GGYLDQPD---NCPERVTDLMRMCWQFNPKMRPTFLEI--------VNLLKDDLHPSFPE 1300
Query: 304 LKKEYSNENAVVKRMQSLQL-----DCVAVPSSRSNSA-TEQPGSLHSSQGLG 350
+ +S EN K +S +L D VP RS+ E+ G LG
Sbjct: 1301 VSFFHSEEN---KAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLG 1350
>gi|110349799 testis-specific protein kinase 2 [Homo sapiens]
Length = 571
Score = 113 bits (282), Expect = 6e-25
Identities = 87/310 (28%), Positives = 154/310 (49%), Gaps = 35/310 (11%)
Query: 22 ELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNCIEHNEA-LLEEAKMMNRLRHSRVVKLL 79
++ SG F +V HR G +M +K N + N A +L+E ++MNRL H +++ +
Sbjct: 63 KIGSGFFSEVFKVRHRASGQVMALKM-----NTLSSNRANMLKEVQLMNRLSHPNILRFM 117
Query: 80 GVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDL 139
GV + +G+ + EY+ GNL +L + + P +V+ ++ +I G+ YLH KG+ H+DL
Sbjct: 118 GVCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDL 177
Query: 140 KPENILV---DNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG--GTLYYMA 194
+N L+ +N + +AD GLA ++ +V ++K G+ ++MA
Sbjct: 178 TSKNCLIKRDENGYSAVVADFGLA-------------EKIPDVSMGSEKLAVVGSPFWMA 224
Query: 195 PEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITE 254
PE L D EK+DV+S+ ++L I A + + + + + V D
Sbjct: 225 PEVLRD--EPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGD--- 279
Query: 255 YCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLK---KEYSNE 311
CP + + L C +P+ RP+F I + LS+L+E +E + L+ + +
Sbjct: 280 -CPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEI-LSRLQEEEQERDRKLQPTARGLLEK 337
Query: 312 NAVVKRMQSL 321
VKR+ SL
Sbjct: 338 APGVKRLSSL 347
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 110 bits (276), Expect = 3e-24
Identities = 84/259 (32%), Positives = 123/259 (47%), Gaps = 39/259 (15%)
Query: 60 LLEEAKMMNRL-RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMST-------- 110
L+ E ++M + RH ++ LLGV +EG +++E KGNL L+A
Sbjct: 477 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG 536
Query: 111 PLSVKGRIILEII--------EGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF 162
P S +G + ++ GM YL + IH+DL N+LV D +KIAD GLA
Sbjct: 537 PRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLA-- 594
Query: 163 KMWSKLNNEEHNELREVDGTAKKNGGTL--YYMAPEHLNDVNAKPTEKSDVYSFAVVLWA 220
+ +D K + G L +MAPE L D T +SDV+SF ++LW
Sbjct: 595 -----------RGVHHIDYYKKTSNGRLPVKWMAPEALFD--RVYTHQSDVWSFGILLWE 641
Query: 221 IFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFP 279
IF PY I ++L ++ G+R D +CP E+ LM+ CW A P RPTF
Sbjct: 642 IFTLGGSPYP-GIPVEELFSLLREGHRM---DRPPHCPPELYGLMRECWHAAPSQRPTFK 697
Query: 280 GIEEKFRPFYLSQLEESVE 298
+ E L+ EE ++
Sbjct: 698 QLVEALDKVLLAVSEEYLD 716
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 110 bits (276), Expect = 3e-24
Identities = 84/259 (32%), Positives = 123/259 (47%), Gaps = 39/259 (15%)
Query: 60 LLEEAKMMNRL-RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMST-------- 110
L+ E ++M + RH ++ LLGV +EG +++E KGNL L+A
Sbjct: 517 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG 576
Query: 111 PLSVKGRIILEII--------EGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF 162
P S +G + ++ GM YL + IH+DL N+LV D +KIAD GLA
Sbjct: 577 PRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLA-- 634
Query: 163 KMWSKLNNEEHNELREVDGTAKKNGGTL--YYMAPEHLNDVNAKPTEKSDVYSFAVVLWA 220
+ +D K + G L +MAPE L D T +SDV+SF ++LW
Sbjct: 635 -----------RGVHHIDYYKKTSNGRLPVKWMAPEALFD--RVYTHQSDVWSFGILLWE 681
Query: 221 IFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFP 279
IF PY I ++L ++ G+R D +CP E+ LM+ CW A P RPTF
Sbjct: 682 IFTLGGSPYP-GIPVEELFSLLREGHRM---DRPPHCPPELYGLMRECWHAAPSQRPTFK 737
Query: 280 GIEEKFRPFYLSQLEESVE 298
+ E L+ EE ++
Sbjct: 738 QLVEALDKVLLAVSEEYLD 756
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 110 bits (276), Expect = 3e-24
Identities = 84/259 (32%), Positives = 123/259 (47%), Gaps = 39/259 (15%)
Query: 60 LLEEAKMMNRL-RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMST-------- 110
L+ E ++M + RH ++ LLGV +EG +++E KGNL L+A
Sbjct: 517 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG 576
Query: 111 PLSVKGRIILEII--------EGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF 162
P S +G + ++ GM YL + IH+DL N+LV D +KIAD GLA
Sbjct: 577 PRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLA-- 634
Query: 163 KMWSKLNNEEHNELREVDGTAKKNGGTL--YYMAPEHLNDVNAKPTEKSDVYSFAVVLWA 220
+ +D K + G L +MAPE L D T +SDV+SF ++LW
Sbjct: 635 -----------RGVHHIDYYKKTSNGRLPVKWMAPEALFD--RVYTHQSDVWSFGILLWE 681
Query: 221 IFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFP 279
IF PY I ++L ++ G+R D +CP E+ LM+ CW A P RPTF
Sbjct: 682 IFTLGGSPYP-GIPVEELFSLLREGHRM---DRPPHCPPELYGLMRECWHAAPSQRPTFK 737
Query: 280 GIEEKFRPFYLSQLEESVE 298
+ E L+ EE ++
Sbjct: 738 QLVEALDKVLLAVSEEYLD 756
>gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens]
Length = 617
Score = 110 bits (275), Expect = 4e-24
Identities = 89/317 (28%), Positives = 136/317 (42%), Gaps = 28/317 (8%)
Query: 16 DFLESAELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSR 74
D + L G FG+ H+ G +M+MK + + E + L E K+M L H
Sbjct: 309 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDE--ETQKTFLTEVKVMRSLDHPN 366
Query: 75 VVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGV 134
V+K +GV+ ++ K +L+ EY+E G L L++ P K R I GM YLH +
Sbjct: 367 VLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCI 426
Query: 135 IHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG------- 187
IH+DL N L+ D + +AD GL S+L EE T KK
Sbjct: 427 IHRDLNSHNCLIKLDKTVVVADFGL------SRLIVEERKRAPMEKATTKKRTLRKNDRK 480
Query: 188 ------GTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCI 241
G Y+MAPE LN E D++SF +VL I + Y + C + +
Sbjct: 481 KRYTVVGNPYWMAPEMLN--GKSYDETVDIFSFGIVLCEIIG--QVYADPDCLPRTLDFG 536
Query: 242 KSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFR--PFYLSQLEESVEE 299
+ + CP L +C PE+RP F +E+ F YL +L +
Sbjct: 537 LNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPA 596
Query: 300 DVKSLKKEYSNENAVVK 316
+++ L S + + +
Sbjct: 597 ELEELDHTVSMQYGLTR 613
>gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]
Length = 638
Score = 110 bits (275), Expect = 4e-24
Identities = 89/317 (28%), Positives = 136/317 (42%), Gaps = 28/317 (8%)
Query: 16 DFLESAELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSR 74
D + L G FG+ H+ G +M+MK + + E + L E K+M L H
Sbjct: 330 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDE--ETQKTFLTEVKVMRSLDHPN 387
Query: 75 VVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGV 134
V+K +GV+ ++ K +L+ EY+E G L L++ P K R I GM YLH +
Sbjct: 388 VLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCI 447
Query: 135 IHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG------- 187
IH+DL N L+ D + +AD GL S+L EE T KK
Sbjct: 448 IHRDLNSHNCLIKLDKTVVVADFGL------SRLIVEERKRAPMEKATTKKRTLRKNDRK 501
Query: 188 ------GTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCI 241
G Y+MAPE LN E D++SF +VL I + Y + C + +
Sbjct: 502 KRYTVVGNPYWMAPEMLN--GKSYDETVDIFSFGIVLCEIIG--QVYADPDCLPRTLDFG 557
Query: 242 KSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFR--PFYLSQLEESVEE 299
+ + CP L +C PE+RP F +E+ F YL +L +
Sbjct: 558 LNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPA 617
Query: 300 DVKSLKKEYSNENAVVK 316
+++ L S + + +
Sbjct: 618 ELEELDHTVSMQYGLTR 634
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 109 bits (272), Expect = 9e-24
Identities = 83/267 (31%), Positives = 134/267 (50%), Gaps = 39/267 (14%)
Query: 22 ELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGV 81
E+ SG FG V L + + + +KT+ +G E +EEA++M +L H ++V+L GV
Sbjct: 368 EIGSGQFGLVHLGYWLNKDKVAIKTIREGAMS---EEDFIEEAEVMMKLSHPKLVQLYGV 424
Query: 82 IIEEGKYSLVMEYMEKGNLMHVLKAE--MSTPLSVKGRIILEIIEGMCYLHGKGVIHKDL 139
+E+ LV E+ME G L L+ + + ++ G + L++ EGM YL VIH+DL
Sbjct: 425 CLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLG-MCLDVCEGMAYLEEACVIHRDL 483
Query: 140 KPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLY---YMAPE 196
N LV + IK++D G+ F + D + GT + + +PE
Sbjct: 484 AARNCLVGENQVIKVSDFGMTRFVL---------------DDQYTSSTGTKFPVKWASPE 528
Query: 197 HLNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEY 255
+ ++ + KSDV+SF V++W +F+ K PYEN +++ I +G R Y
Sbjct: 529 VFS--FSRYSSKSDVWSFGVLMWEVFSEGKIPYENR-SNSEVVEDISTGFR-------LY 578
Query: 256 CPR----EIISLMKLCWEANPEARPTF 278
PR + +M CW+ PE RP F
Sbjct: 579 KPRLASTHVYQIMNHCWKERPEDRPAF 605
>gi|4505001 LIM domain kinase 1 [Homo sapiens]
Length = 647
Score = 108 bits (271), Expect = 1e-23
Identities = 80/274 (29%), Positives = 127/274 (46%), Gaps = 11/274 (4%)
Query: 13 KSSDFLESAELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNCIEHNEALLEEAKMMNRLR 71
+ SD + L G FG+ HR G +M+MK + + E L+E K+M L
Sbjct: 335 RPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDE--ETQRTFLKEVKVMRCLE 392
Query: 72 HSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKA-EMSTPLSVKGRIILEIIEGMCYLH 130
H V+K +GV+ ++ + + + EY++ G L ++K+ + P S + +I GM YLH
Sbjct: 393 HPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLH 452
Query: 131 GKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKN-GGT 189
+IH+DL N LV + ++ +AD GLA + K E L++ D + G
Sbjct: 453 SMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGN 512
Query: 190 LYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDV 249
Y+MAPE +N EK DV+SF +VL I + + M R +
Sbjct: 513 PYWMAPEMIN--GRSYDEKVDVFSFGIVLCEIIGRVNADPDYL---PRTMDFGLNVRGFL 567
Query: 250 DD-ITEYCPREIISLMKLCWEANPEARPTFPGIE 282
D CP + C + +PE RP+F +E
Sbjct: 568 DRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLE 601
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 108 bits (269), Expect = 2e-23
Identities = 84/254 (33%), Positives = 119/254 (46%), Gaps = 40/254 (15%)
Query: 53 CIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKA------ 106
CIE L+EA +M + VV+LLGV+ + ++ME M +G+L L++
Sbjct: 1024 CIE----FLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE 1079
Query: 107 -EMSTPLSVKGRIIL---EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF 162
P G +I EI +GM YL +H+DL N +V DF +KI D G+
Sbjct: 1080 NNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMT-- 1137
Query: 163 KMWSKLNNEEHNELREVDGTAKKNGGTL--YYMAPEHLNDVNAKPTEKSDVYSFAVVLWA 220
++ E D K G L +MAPE L D T SDV+SF VVLW
Sbjct: 1138 -----------RDVYETDYYRKGGKGLLPVRWMAPESLKD--GIFTTHSDVWSFGVVLWE 1184
Query: 221 IFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTF- 278
I ++PY+ EQ L + G V + E CP ++ LM CW+ NP RP+F
Sbjct: 1185 IVTLAEQPYQGLSNEQVLKFVMDGG----VLEELEGCPLQLQELMSRCWQPNPRLRPSFT 1240
Query: 279 ---PGIEEKFRPFY 289
I+E+ RP +
Sbjct: 1241 HILDSIQEELRPSF 1254
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 107 bits (267), Expect = 4e-23
Identities = 87/275 (31%), Positives = 135/275 (49%), Gaps = 33/275 (12%)
Query: 22 ELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGV 81
+L SG FG+V + +++ + +KT+ +G EA L EA +M L+H R+V+L V
Sbjct: 246 KLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMS---PEAFLGEANVMKALQHERLVRLYAV 302
Query: 82 IIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL--EIIEGMCYLHGKGVIHKDL 139
+ +E Y +V EYM +G L+ LK + + LS+ I + +I EGM Y+ IH+DL
Sbjct: 303 VTKEPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDL 361
Query: 140 KPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLY---YMAPE 196
+ NILV KIAD GLA R +D G + + APE
Sbjct: 362 RAANILVSEALCCKIADFGLA----------------RIIDSEYTAQEGAKFPIKWTAPE 405
Query: 197 HLNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEY 255
++ T K+DV+SF V+L + + PY + ++I ++ G R D
Sbjct: 406 AIH--FGVFTIKADVWSFGVLLMEVVTYGRVPYP-GMSNPEVIRNLERGYRMPRPDT--- 459
Query: 256 CPREII-SLMKLCWEANPEARPTFPGIEEKFRPFY 289
CP E+ ++ CW + PE RPTF ++ FY
Sbjct: 460 CPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFY 494
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 107 bits (266), Expect = 5e-23
Identities = 81/244 (33%), Positives = 113/244 (46%), Gaps = 39/244 (15%)
Query: 60 LLEEAKMMNRL-RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEM---------- 108
L+ E +MM + +H ++ LLG ++G +++EY KGNL L+A
Sbjct: 437 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 496
Query: 109 ----STPLSVKGRI--ILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF 162
LS K + ++ GM YL K IH+DL N+LV D +KIAD GLA
Sbjct: 497 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA-- 554
Query: 163 KMWSKLNNEEHNELREVDGTAKKNGGTL--YYMAPEHLNDVNAKPTEKSDVYSFAVVLWA 220
++ +D K G L +MAPE L D T +SDV+SF V+LW
Sbjct: 555 -----------RDIHHIDYYKKTTNGRLPVKWMAPEALFD--RIYTHQSDVWSFGVLLWE 601
Query: 221 IFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFP 279
IF PY E +L +K G+R D C E+ +M+ CW A P RPTF
Sbjct: 602 IFTLGGSPYPGVPVE-ELFKLLKEGHRMDK---PSNCTNELYMMMRDCWHAVPSQRPTFK 657
Query: 280 GIEE 283
+ E
Sbjct: 658 QLVE 661
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 107 bits (266), Expect = 5e-23
Identities = 81/244 (33%), Positives = 113/244 (46%), Gaps = 39/244 (15%)
Query: 60 LLEEAKMMNRL-RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEM---------- 108
L+ E +MM + +H ++ LLG ++G +++EY KGNL L+A
Sbjct: 439 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 498
Query: 109 ----STPLSVKGRI--ILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF 162
LS K + ++ GM YL K IH+DL N+LV D +KIAD GLA
Sbjct: 499 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA-- 556
Query: 163 KMWSKLNNEEHNELREVDGTAKKNGGTL--YYMAPEHLNDVNAKPTEKSDVYSFAVVLWA 220
++ +D K G L +MAPE L D T +SDV+SF V+LW
Sbjct: 557 -----------RDIHHIDYYKKTTNGRLPVKWMAPEALFD--RIYTHQSDVWSFGVLLWE 603
Query: 221 IFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFP 279
IF PY E +L +K G+R D C E+ +M+ CW A P RPTF
Sbjct: 604 IFTLGGSPYPGVPVE-ELFKLLKEGHRMDK---PSNCTNELYMMMRDCWHAVPSQRPTFK 659
Query: 280 GIEE 283
+ E
Sbjct: 660 QLVE 663
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,466,535
Number of Sequences: 37866
Number of extensions: 1370002
Number of successful extensions: 5086
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 727
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 3281
Number of HSP's gapped (non-prelim): 1043
length of query: 671
length of database: 18,247,518
effective HSP length: 109
effective length of query: 562
effective length of database: 14,120,124
effective search space: 7935509688
effective search space used: 7935509688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.