Guide to the Human Genome
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Search of human proteins with 51702240

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 3 isoform a [Homo sapiens]
         (588 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula...  1207   0.0  
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula...  1153   0.0  
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul...   689   0.0  
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat...   687   0.0  
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula...   417   e-116
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula...   278   1e-74
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula...   276   5e-74
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula...   276   5e-74
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula...   276   5e-74
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula...   276   5e-74
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat...   274   2e-73
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat...   263   4e-70
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat...   260   2e-69
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]               207   2e-53
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]                207   2e-53
gi|10190706 CDC-like kinase 4 [Homo sapiens]                          204   2e-52
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ...   194   1e-49
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ...   194   1e-49
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [...   192   6e-49
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [...   192   6e-49
gi|47717134 CDC-like kinase 2 [Homo sapiens]                          189   5e-48
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ...   188   1e-47
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ...   188   1e-47
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]               187   2e-47
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]               187   2e-47
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]   180   4e-45
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]      162   1e-39
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]        150   2e-36
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ...   143   4e-34
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ...   140   4e-33

>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform a [Homo sapiens]
          Length = 588

 Score = 1207 bits (3124), Expect = 0.0
 Identities = 588/588 (100%), Positives = 588/588 (100%)

Query: 1   MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR 60
           MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
Sbjct: 1   MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR 60

Query: 61  RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS 120
           RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
Sbjct: 61  RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS 120

Query: 121 SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG 180
           SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
Sbjct: 121 SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG 180

Query: 181 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240
           VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
Sbjct: 181 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240

Query: 241 RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK 300
           RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
Sbjct: 241 RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK 300

Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360
           KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
Sbjct: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360

Query: 361 FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420
           FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
Sbjct: 361 FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420

Query: 421 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480
           MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
Sbjct: 421 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480

Query: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540
           KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
Sbjct: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540

Query: 541 VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS 588
           VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
Sbjct: 541 VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS 588


>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform b [Homo sapiens]
          Length = 568

 Score = 1153 bits (2983), Expect = 0.0
 Identities = 562/565 (99%), Positives = 564/565 (99%)

Query: 24  QRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEM 83
           + +LGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEM
Sbjct: 4   KEKLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEM 63

Query: 84  KVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTP 143
           KVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTP
Sbjct: 64  KVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTP 123

Query: 144 EQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRD 203
           EQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRD
Sbjct: 124 EQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRD 183

Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263
           HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ
Sbjct: 184 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 243

Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323
           DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL
Sbjct: 244 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 303

Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG 383
           DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG
Sbjct: 304 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG 363

Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443
           SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI
Sbjct: 364 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 423

Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503
           NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL
Sbjct: 424 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 483

Query: 504 HWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIAN 563
           HWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIAN
Sbjct: 484 HWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIAN 543

Query: 564 KLKANLMSETNGSIPLCSVLPKLIS 588
           KLKANLMSETNGSIPLCSVLPKLIS
Sbjct: 544 KLKANLMSETNGSIPLCSVLPKLIS 568


>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
           regulated kinase 2 isoform 2 [Homo sapiens]
          Length = 601

 Score =  689 bits (1777), Expect = 0.0
 Identities = 345/556 (62%), Positives = 423/556 (76%), Gaps = 21/556 (3%)

Query: 52  NPSEPPPPRRLNMTTEQFTGDHTQHFLDG---------GEMKVEQLFQEFGNRKSN-TIQ 101
           +P   PP R  N      T   ++H ++          G+++V+QLF++  N+++  T Q
Sbjct: 48  SPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQ 107

Query: 102 SDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAP-------KVVPLTPEQALKQYKHHL 154
            +G++   K    V   +  D ++  + +S+S          K  P+TPEQA+KQY   L
Sbjct: 108 PNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKL 167

Query: 155 TAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKI 214
           TA+E  EI +YPEIYF+G NAKKR G+ GGPNNGGYDD  G+Y+ VP DH+AYRYEVLK+
Sbjct: 168 TAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKV 227

Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274
           IGKGSFGQV + YDHK+ Q+VALKMVRNEKRFHRQAAEEIRILEHL+KQDK  +MNVIHM
Sbjct: 228 IGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHM 287

Query: 275 LESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHC 334
           LE+FTFRNH+CM FELLS++LYELIKKNKFQGFS+ LVRKFA SILQ LDALHKN+IIHC
Sbjct: 288 LENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHC 347

Query: 335 DLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWS 394
           DLKPENILLK  GRS  KVIDFGSSC+E+Q++YTYIQSRFYRAPE+ILG+RY  PID+WS
Sbjct: 348 DLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWS 407

Query: 395 FGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSV 454
            GCILAELLTG PL PGEDEGDQLACM+ELLGMP  KLL+ SKRAK F++SKG PRYC+V
Sbjct: 408 LGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTV 467

Query: 455 TTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPA 514
           TT +DG VVL GGRSRRGK RGPP S++WG ALKGCDD LF++FLK+CL WDP+ R+TP 
Sbjct: 468 TTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPG 527

Query: 515 QALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANL--MSE 572
           QALRHPW+ + +P+P  T +K S KR+     A   + SKLPP    A+KL+ NL  M++
Sbjct: 528 QALRHPWLRRRLPKP-PTGEKTSVKRITESTGAITSI-SKLPPPSSSASKLRTNLAQMTD 585

Query: 573 TNGSIPLCSVLPKLIS 588
            NG+I   +VLPKL+S
Sbjct: 586 ANGNIQQRTVLPKLVS 601


>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 2 isoform 1 [Homo sapiens]
          Length = 528

 Score =  687 bits (1772), Expect = 0.0
 Identities = 338/518 (65%), Positives = 411/518 (79%), Gaps = 12/518 (2%)

Query: 81  GEMKVEQLFQEFGNRKSN-TIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAP--- 136
           G+++V+QLF++  N+++  T Q +G++   K    V   +  D ++  + +S+S      
Sbjct: 13  GQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEG 72

Query: 137 ----KVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDD 192
               K  P+TPEQA+KQY   LTA+E  EI +YPEIYF+G NAKKR G+ GGPNNGGYDD
Sbjct: 73  MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDD 132

Query: 193 ADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE 252
             G+Y+ VP DH+AYRYEVLK+IGKGSFGQV + YDHK+ Q+VALKMVRNEKRFHRQAAE
Sbjct: 133 DQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAE 192

Query: 253 EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLV 312
           EIRILEHL+KQDK  +MNVIHMLE+FTFRNH+CM FELLS++LYELIKKNKFQGFS+ LV
Sbjct: 193 EIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLV 252

Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS 372
           RKFA SILQ LDALHKN+IIHCDLKPENILLK  GRS  KVIDFGSSC+E+Q++YTYIQS
Sbjct: 253 RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQS 312

Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432
           RFYRAPE+ILG+RY  PID+WS GCILAELLTG PL PGEDEGDQLACM+ELLGMP  KL
Sbjct: 313 RFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKL 372

Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492
           L+ SKRAK F++SKG PRYC+VTT +DG VVL GGRSRRGK RGPP S++WG ALKGCDD
Sbjct: 373 LDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD 432

Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLG 552
            LF++FLK+CL WDP+ R+TP QALRHPW+ + +P+P  T +K S KR+     A   + 
Sbjct: 433 PLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP-PTGEKTSVKRITESTGAITSI- 490

Query: 553 SKLPPVVGIANKLKANL--MSETNGSIPLCSVLPKLIS 588
           SKLPP    A+KL+ NL  M++ NG+I   +VLPKL+S
Sbjct: 491 SKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS 528


>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 4 [Homo sapiens]
          Length = 520

 Score =  417 bits (1073), Expect = e-116
 Identities = 216/415 (52%), Positives = 283/415 (68%), Gaps = 24/415 (5%)

Query: 124 LNTVKSNSSSKAPKV--VPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGV 181
           + T    +  K+PK   V LT  +ALK +K+ L+ YE+ EI+ Y E++F+G  AKK    
Sbjct: 17  IKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTA 76

Query: 182 IGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR 241
               +   +DD  G Y+ V  DH+AYRYEVL+ IGKGSFGQVA+  DHK  + VALK++R
Sbjct: 77  PEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIR 136

Query: 242 NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK 301
           N+KRFH+QA  E++ILE L+K+DK  + NV+HM + F FRNH C+ FELL I+LYEL+K 
Sbjct: 137 NKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKN 196

Query: 302 NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF 361
           N FQGFS+ +VR+F  S+L+ L  L   KIIHCDLKPENI+L   G++S KVIDFGSSC+
Sbjct: 197 NNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256

Query: 362 EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421
           E+QK+YTYIQSRFYR+PE+ILG  Y   ID+WS GCI AEL TG PLFPGE+E +QLAC+
Sbjct: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316

Query: 422 MELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSK 481
           ME+LG+PP   ++ + R + F +SKG P+  +               + RGKKR  P SK
Sbjct: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNIT---------------NNRGKKR-YPDSK 360

Query: 482 DWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKS-----VPRPLT 531
           D    LK  D   F++FL+RCL W+PS R+TP QAL+H WI +S      PRP T
Sbjct: 361 DLTMVLKTYDT-SFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQT 414


>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 2 [Homo sapiens]
          Length = 754

 Score =  278 bits (711), Expect = 1e-74
 Identities = 165/442 (37%), Positives = 244/442 (55%), Gaps = 13/442 (2%)

Query: 105 ISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQA--LKQYKHHLTAYEKLEI 162
           ISD +  + + S        N  +   + + P   PL       +K YKH    Y   + 
Sbjct: 48  ISDQQVSALSYSDQIQQPLTNQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKK 107

Query: 163 INYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQ 222
             + +      + KK   V     N GYDD +  YI    +    RYE+  +IGKGSFGQ
Sbjct: 108 RRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQ 163

Query: 223 VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRN 282
           V + YD   +++VA+K+++N+K F  QA  E+R+LE + K D      ++H+   F FRN
Sbjct: 164 VVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRN 223

Query: 283 HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPEN 340
           H+C+ FE+LS +LY+L++   F+G S+ L RKFAQ +  +L   A  +  IIHCDLKPEN
Sbjct: 224 HLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPEN 283

Query: 341 ILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILA 400
           ILL +  RS+ K++DFGSSC   Q++Y YIQSRFYR+PE++LG  Y   ID+WS GCIL 
Sbjct: 284 ILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILV 343

Query: 401 ELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADG 460
           E+ TG+PLF G +E DQ+  ++E+LG+PP  +L+Q+ +A+ F        +    T+   
Sbjct: 344 EMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGK 403

Query: 461 RVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFLKRCLHWDPSARLTPAQ 515
           R     G  +     G + G PG +  G +     DYL F + + R L +DP  R+ P  
Sbjct: 404 REYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYY 463

Query: 516 ALRHPWISKSVPRPLTTIDKVS 537
           AL+H +  K+      T + VS
Sbjct: 464 ALQHSFFKKTADEGTNTSNSVS 485


>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 5 [Homo sapiens]
          Length = 529

 Score =  276 bits (705), Expect = 5e-74
 Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%)

Query: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 206
           +K YKH    Y   +   + +      + KK   V     N GYDD +  YI    +   
Sbjct: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156

Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266
            RYE+  +IGKGSFGQV + YD   +++VA+K+++N+K F  QA  E+R+LE + K D  
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216

Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 324
               ++H+   F FRNH+C+ FE+LS +LY+L++   F+G S+ L RKFAQ +  +L   
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276

Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384
           A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q++Y YIQSRFYR+PE++LG 
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336

Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444
            Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+LG+PP  +L+Q+ +A+ F  
Sbjct: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396

Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 499
                 +    T+   R     G  +     G + G PG +  G +     DYL F + +
Sbjct: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456

Query: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537
            R L +DP  R+ P  AL+H +  K+      T + VS
Sbjct: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494


>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 4 [Homo sapiens]
          Length = 540

 Score =  276 bits (705), Expect = 5e-74
 Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%)

Query: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 206
           +K YKH    Y   +   + +      + KK   V     N GYDD +  YI    +   
Sbjct: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156

Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266
            RYE+  +IGKGSFGQV + YD   +++VA+K+++N+K F  QA  E+R+LE + K D  
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216

Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 324
               ++H+   F FRNH+C+ FE+LS +LY+L++   F+G S+ L RKFAQ +  +L   
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276

Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384
           A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q++Y YIQSRFYR+PE++LG 
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336

Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444
            Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+LG+PP  +L+Q+ +A+ F  
Sbjct: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396

Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 499
                 +    T+   R     G  +     G + G PG +  G +     DYL F + +
Sbjct: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456

Query: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537
            R L +DP  R+ P  AL+H +  K+      T + VS
Sbjct: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494


>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 3 [Homo sapiens]
          Length = 584

 Score =  276 bits (705), Expect = 5e-74
 Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%)

Query: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 206
           +K YKH    Y   +   + +      + KK   V     N GYDD +  YI    +   
Sbjct: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156

Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266
            RYE+  +IGKGSFGQV + YD   +++VA+K+++N+K F  QA  E+R+LE + K D  
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216

Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 324
               ++H+   F FRNH+C+ FE+LS +LY+L++   F+G S+ L RKFAQ +  +L   
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276

Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384
           A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q++Y YIQSRFYR+PE++LG 
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336

Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444
            Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+LG+PP  +L+Q+ +A+ F  
Sbjct: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396

Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 499
                 +    T+   R     G  +     G + G PG +  G +     DYL F + +
Sbjct: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456

Query: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537
            R L +DP  R+ P  AL+H +  K+      T + VS
Sbjct: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494


>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 1 [Homo sapiens]
          Length = 763

 Score =  276 bits (705), Expect = 5e-74
 Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%)

Query: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 206
           +K YKH    Y   +   + +      + KK   V     N GYDD +  YI    +   
Sbjct: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156

Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266
            RYE+  +IGKGSFGQV + YD   +++VA+K+++N+K F  QA  E+R+LE + K D  
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216

Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 324
               ++H+   F FRNH+C+ FE+LS +LY+L++   F+G S+ L RKFAQ +  +L   
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276

Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384
           A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q++Y YIQSRFYR+PE++LG 
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336

Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444
            Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+LG+PP  +L+Q+ +A+ F  
Sbjct: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396

Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 499
                 +    T+   R     G  +     G + G PG +  G +     DYL F + +
Sbjct: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456

Query: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537
            R L +DP  R+ P  AL+H +  K+      T + VS
Sbjct: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494


>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform a [Homo sapiens]
          Length = 629

 Score =  274 bits (700), Expect = 2e-73
 Identities = 150/355 (42%), Positives = 221/355 (62%), Gaps = 11/355 (3%)

Query: 187 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246
           N GYDD +  YI    +    RYE+  +IGKGSFGQV + YDH+ ++ VA+K+++N+K F
Sbjct: 89  NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148

Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 306
             QA  E+R+LE + + D      ++H+   F FRNH+C+ FELLS +LY+L++   F+G
Sbjct: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208

Query: 307 FSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364
            S+ L RK AQ +  +L   A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q
Sbjct: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268

Query: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424
           ++Y YIQSRFYR+PE++LG+ Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+
Sbjct: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328

Query: 425 LGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRR-----GKKRGPP 478
           LG+PP  +L+Q+ +A KYF    G     ++    + R    G  +RR     G + G P
Sbjct: 329 LGIPPAAMLDQAPKARKYFERLPG--GGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGP 386

Query: 479 GSKDWGTALKGCDDYL-FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 532
           G +  G       DYL F + + R L ++P+AR++P  AL+H +  ++      T
Sbjct: 387 GGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 441


>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform c [Homo sapiens]
          Length = 601

 Score =  263 bits (671), Expect = 4e-70
 Identities = 144/349 (41%), Positives = 211/349 (60%), Gaps = 27/349 (7%)

Query: 187 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246
           N GYDD +  YI    +    RYE+  +IGKGSFGQV + YDH+ ++ VA+K+++N+K F
Sbjct: 89  NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148

Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 306
             QA  E+R+LE + + D      ++H+   F FRNH+C+ FELLS +LY+L++   F+G
Sbjct: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208

Query: 307 FSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364
            S+ L RK AQ +  +L   A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q
Sbjct: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268

Query: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424
           ++Y YIQSRFYR+PE++LG+ Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+
Sbjct: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328

Query: 425 LGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 483
           LG+PP  +L+Q+ +A KYF    G                  GG + R  K      +  
Sbjct: 329 LGIPPAAMLDQAPKARKYFERLPG------------------GGWTLRRTKELRKDYQGP 370

Query: 484 GTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 532
           GT        L  + + R L ++P+AR++P  AL+H +  ++      T
Sbjct: 371 GTR------RLQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 413


>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform b [Homo sapiens]
          Length = 589

 Score =  260 bits (665), Expect = 2e-69
 Identities = 142/349 (40%), Positives = 208/349 (59%), Gaps = 39/349 (11%)

Query: 187 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246
           N GYDD +  YI    +    RYE+  +IGKGSFGQV + YDH+ ++ VA+K+++N+K F
Sbjct: 89  NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148

Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 306
             QA  E+R+LE + + D      ++H+   F FRNH+C+ FELLS +LY+L++   F+G
Sbjct: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208

Query: 307 FSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364
            S+ L RK AQ +  +L   A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q
Sbjct: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268

Query: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424
           ++Y YIQSRFYR+PE++LG+ Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+
Sbjct: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328

Query: 425 LGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 483
           LG+PP  +L+Q+ +A KYF    G                  GG + R  K         
Sbjct: 329 LGIPPAAMLDQAPKARKYFERLPG------------------GGWTLRRTKE-------- 362

Query: 484 GTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 532
                     L  + + R L ++P+AR++P  AL+H +  ++      T
Sbjct: 363 ----------LRKDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 401


>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
          Length = 526

 Score =  207 bits (527), Expect = 2e-53
 Identities = 125/349 (35%), Positives = 192/349 (55%), Gaps = 33/349 (9%)

Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
           DD +G  I    D L+ RYE++  +G+G+FG+V    DHK   ++VA+K+V+N  R+   
Sbjct: 185 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 244

Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
           A  EI++LEHL   D   +   + MLE F    H+C+ FELL +  Y+ IK+N F  F +
Sbjct: 245 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 304

Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------------LKHHGRS----STK 352
             +RK A  I +S++ LH NK+ H DLKPENIL             +K   R+      K
Sbjct: 305 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 364

Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
           V+DFGS+ ++ +   T + +R YRAPE+IL   +S P D+WS GCIL E   G  +FP  
Sbjct: 365 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 424

Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
           D  + LA M  +LG  P  +++++++ KYF +     R       + GR V     SRR 
Sbjct: 425 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHD----RLDWDEHSSAGRYV-----SRRC 475

Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 521
           K       K++  +     + LF + +++ L +DP+ R+T  +AL+HP+
Sbjct: 476 KPL-----KEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 518


>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
          Length = 484

 Score =  207 bits (527), Expect = 2e-53
 Identities = 125/349 (35%), Positives = 192/349 (55%), Gaps = 33/349 (9%)

Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
           DD +G  I    D L+ RYE++  +G+G+FG+V    DHK   ++VA+K+V+N  R+   
Sbjct: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202

Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
           A  EI++LEHL   D   +   + MLE F    H+C+ FELL +  Y+ IK+N F  F +
Sbjct: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262

Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------------LKHHGRS----STK 352
             +RK A  I +S++ LH NK+ H DLKPENIL             +K   R+      K
Sbjct: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322

Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
           V+DFGS+ ++ +   T + +R YRAPE+IL   +S P D+WS GCIL E   G  +FP  
Sbjct: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382

Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
           D  + LA M  +LG  P  +++++++ KYF +     R       + GR V     SRR 
Sbjct: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHD----RLDWDEHSSAGRYV-----SRRC 433

Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 521
           K       K++  +     + LF + +++ L +DP+ R+T  +AL+HP+
Sbjct: 434 KPL-----KEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476


>gi|10190706 CDC-like kinase 4 [Homo sapiens]
          Length = 481

 Score =  204 bits (519), Expect = 2e-52
 Identities = 123/349 (35%), Positives = 189/349 (54%), Gaps = 33/349 (9%)

Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
           DD +G  I    D L  RYE++  +G+G+FG+V    DH +   +VA+K+V+N  R+   
Sbjct: 141 DDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREA 200

Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
           A  EI++LEHL   D       + MLE F    HVC+ FELL +  Y+ IK+N F  F +
Sbjct: 201 ARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQI 260

Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------LKHHGR----------SSTK 352
             +R+ A  I QS++ LH NK+ H DLKPENIL       +K++ +          +  K
Sbjct: 261 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 320

Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
           V+DFGS+ ++ +   T + +R YRAPE+IL   +S P D+WS GCIL E   G  +F   
Sbjct: 321 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTH 380

Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
           D  + LA M  +LG  P  +++++++ KYF ++           Q D       GR  R 
Sbjct: 381 DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHN-----------QLDWDEHSSAGRYVR- 428

Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 521
            +R  P  K++        + LF + ++R L +DP+ R+T  +AL+HP+
Sbjct: 429 -RRCKP-LKEFMLCHDEEHEKLF-DLVRRMLEYDPTQRITLDEALQHPF 474


>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
           [Homo sapiens]
          Length = 1171

 Score =  194 bits (494), Expect = 1e-49
 Identities = 119/355 (33%), Positives = 182/355 (51%), Gaps = 18/355 (5%)

Query: 186 NNGGYDDADGAYI-HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244
           N+G   + D   + H     +   YEVL+ +G+G+FGQV + +     + VA+K+++N  
Sbjct: 175 NSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 234

Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304
            + RQ   E+ IL  L  +      N +   E F  +NH C+ FE+L  +LY+ +K+NKF
Sbjct: 235 SYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293

Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFE 362
               ++ +R   Q +  +L  L    +IH DLKPENI+L    R     KVIDFGS+   
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353

Query: 363 YQKLY-TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421
            + +  TY+QSR+YRAPEIILG  +   ID+WS GC++AEL  G PL+PG  E DQ+  +
Sbjct: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413

Query: 422 MELLGMPPPKLLEQ-SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----R 475
            +  G+P   LL   +K  ++F      P         D      G +S+  +K      
Sbjct: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473

Query: 476 GPPGSKDWGTALKGCDDYL-------FIEFLKRCLHWDPSARLTPAQALRHPWIS 523
                 +  T L+G D  +       FI+ LK+ L  D   R+TP + L HP+++
Sbjct: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVT 528


>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
           [Homo sapiens]
          Length = 1198

 Score =  194 bits (494), Expect = 1e-49
 Identities = 119/355 (33%), Positives = 182/355 (51%), Gaps = 18/355 (5%)

Query: 186 NNGGYDDADGAYI-HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244
           N+G   + D   + H     +   YEVL+ +G+G+FGQV + +     + VA+K+++N  
Sbjct: 175 NSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 234

Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304
            + RQ   E+ IL  L  +      N +   E F  +NH C+ FE+L  +LY+ +K+NKF
Sbjct: 235 SYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293

Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFE 362
               ++ +R   Q +  +L  L    +IH DLKPENI+L    R     KVIDFGS+   
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353

Query: 363 YQKLY-TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421
            + +  TY+QSR+YRAPEIILG  +   ID+WS GC++AEL  G PL+PG  E DQ+  +
Sbjct: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413

Query: 422 MELLGMPPPKLLEQ-SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----R 475
            +  G+P   LL   +K  ++F      P         D      G +S+  +K      
Sbjct: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473

Query: 476 GPPGSKDWGTALKGCDDYL-------FIEFLKRCLHWDPSARLTPAQALRHPWIS 523
                 +  T L+G D  +       FI+ LK+ L  D   R+TP + L HP+++
Sbjct: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVT 528


>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
           [Homo sapiens]
          Length = 1210

 Score =  192 bits (489), Expect = 6e-49
 Identities = 115/333 (34%), Positives = 178/333 (53%), Gaps = 21/333 (6%)

Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
           YEVL+ +G+G+FGQVA+ +    ++ VA+K+++N   + RQ   E+ IL  L  ++    
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSEN-ADE 248

Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
            N +   E F  +NH C+ FE+L  +LY+ +K+NKF    ++ +R   Q +  +L  L  
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308

Query: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385
             +IH DLKPENI+L    R     KVIDFGS+    + +  TY+QSR+YRAPEIILG  
Sbjct: 309 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP 368

Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN- 444
           +   ID+WS GC++AEL  G PL+PG  E DQ+  + +  G+P   LL    +   F N 
Sbjct: 369 FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR 428

Query: 445 --SKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----RGPPGSKDWGTALKGCDDYL--- 494
             + G P +   T +     +  G +S+  +K            +  T L+G D      
Sbjct: 429 DPNLGYPLWRLKTPEE--HELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKA 486

Query: 495 ----FIEFLKRCLHWDPSARLTPAQALRHPWIS 523
               +I+ LK+ L  D   R+TP + L H +++
Sbjct: 487 DRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 519


>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
           [Homo sapiens]
          Length = 1075

 Score =  192 bits (489), Expect = 6e-49
 Identities = 115/333 (34%), Positives = 178/333 (53%), Gaps = 21/333 (6%)

Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
           YEVL+ +G+G+FGQVA+ +    ++ VA+K+++N   + RQ   E+ IL  L  ++    
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSEN-ADE 248

Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
            N +   E F  +NH C+ FE+L  +LY+ +K+NKF    ++ +R   Q +  +L  L  
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308

Query: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385
             +IH DLKPENI+L    R     KVIDFGS+    + +  TY+QSR+YRAPEIILG  
Sbjct: 309 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP 368

Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN- 444
           +   ID+WS GC++AEL  G PL+PG  E DQ+  + +  G+P   LL    +   F N 
Sbjct: 369 FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR 428

Query: 445 --SKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----RGPPGSKDWGTALKGCDDYL--- 494
             + G P +   T +     +  G +S+  +K            +  T L+G D      
Sbjct: 429 DPNLGYPLWRLKTPEE--HELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKA 486

Query: 495 ----FIEFLKRCLHWDPSARLTPAQALRHPWIS 523
               +I+ LK+ L  D   R+TP + L H +++
Sbjct: 487 DRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 519


>gi|47717134 CDC-like kinase 2 [Homo sapiens]
          Length = 498

 Score =  189 bits (481), Expect = 5e-48
 Identities = 110/357 (30%), Positives = 185/357 (51%), Gaps = 33/357 (9%)

Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
           DDA+G  I+   D L  RYE++  +G+G+FG+V +  DH+     VALK+++N +++   
Sbjct: 144 DDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 203

Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
           A  EI +LE + ++D       + M + F +  H+C++FELL +  ++ +K N +  + +
Sbjct: 204 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPI 263

Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-------------KHHGRS----STK 352
             VR  A  + Q++  LH NK+ H DLKPENIL              K   RS    + +
Sbjct: 264 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 323

Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
           V+DFGS+ F+++   T + +R YRAPE+IL   +S P D+WS GCI+ E   G  LF   
Sbjct: 324 VVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTH 383

Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
           D  + LA M  +LG  P +++ ++++ KYF       R       + GR V    +  R 
Sbjct: 384 DNREHLAMMERILGPIPSRMIRKTRKQKYFYRG----RLDWDENTSAGRYVRENCKPLRR 439

Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529
                          +  + +   + ++  L ++P+ RLT  +AL+HP+ ++    P
Sbjct: 440 Y-----------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEP 485


>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
           [Homo sapiens]
          Length = 1194

 Score =  188 bits (478), Expect = 1e-47
 Identities = 114/331 (34%), Positives = 174/331 (52%), Gaps = 17/331 (5%)

Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
           YEVL  +G+G+FGQV + +     + VA+K+++N   + RQ   E+ IL  L  ++    
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTEN-ADE 255

Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
            N +   E F  RNH C+ FE+L  +LY+ +K+NKF    ++++R   Q +  +L  L  
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315

Query: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385
             +IH DLKPENI+L    R     KVIDFGS+    + +  TY+QSR+YRAPEIILG  
Sbjct: 316 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP 375

Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE-QSKRAKYFIN 444
           +   ID+WS GC++AEL  G PL+PG  E DQ+  + +  G+P  +LL   +K  ++F  
Sbjct: 376 FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCK 435

Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA-----LKG-------CDD 492
              +          +      G +S+  +K       D         L+G        D 
Sbjct: 436 ETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADR 495

Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523
             F+  LK+ L  D   R+TPA+ L HP+++
Sbjct: 496 REFVSLLKKMLLIDADLRITPAETLNHPFVN 526


>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
           [Homo sapiens]
          Length = 1215

 Score =  188 bits (478), Expect = 1e-47
 Identities = 114/331 (34%), Positives = 174/331 (52%), Gaps = 17/331 (5%)

Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
           YEVL  +G+G+FGQV + +     + VA+K+++N   + RQ   E+ IL  L  ++    
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTEN-ADE 255

Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
            N +   E F  RNH C+ FE+L  +LY+ +K+NKF    ++++R   Q +  +L  L  
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315

Query: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385
             +IH DLKPENI+L    R     KVIDFGS+    + +  TY+QSR+YRAPEIILG  
Sbjct: 316 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP 375

Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE-QSKRAKYFIN 444
           +   ID+WS GC++AEL  G PL+PG  E DQ+  + +  G+P  +LL   +K  ++F  
Sbjct: 376 FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCK 435

Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA-----LKG-------CDD 492
              +          +      G +S+  +K       D         L+G        D 
Sbjct: 436 ETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADR 495

Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523
             F+  LK+ L  D   R+TPA+ L HP+++
Sbjct: 496 REFVSLLKKMLLIDADLRITPAETLNHPFVN 526


>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
          Length = 638

 Score =  187 bits (475), Expect = 2e-47
 Identities = 114/355 (32%), Positives = 183/355 (51%), Gaps = 33/355 (9%)

Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHRQ 249
           DD +G  +    D L  RYE++  +G+G+FG+V    DH + +  VALK++RN  ++   
Sbjct: 286 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 345

Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
           A  EI +L+ +K++DK      + M + F F  H+C+AFELL  + +E +K+N FQ + +
Sbjct: 346 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 405

Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-----------------KHHGRSSTK 352
             VR  A  +  +L  LH+N++ H DLKPENIL                  K    +S +
Sbjct: 406 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 465

Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
           V DFGS+ F+++   T + +R YR PE+IL   ++ P D+WS GCIL E   G  LF   
Sbjct: 466 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 525

Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
           +  + L  M ++LG  P  ++ ++++ KYF     +    S    +DGR V         
Sbjct: 526 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENS----SDGRYV--------- 572

Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527
            K      K +       +     + ++R L +DP+ R+T A+AL HP+ +   P
Sbjct: 573 -KENCKPLKSY-MLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTP 625


>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
          Length = 490

 Score =  187 bits (475), Expect = 2e-47
 Identities = 114/355 (32%), Positives = 183/355 (51%), Gaps = 33/355 (9%)

Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHRQ 249
           DD +G  +    D L  RYE++  +G+G+FG+V    DH + +  VALK++RN  ++   
Sbjct: 138 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 197

Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
           A  EI +L+ +K++DK      + M + F F  H+C+AFELL  + +E +K+N FQ + +
Sbjct: 198 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 257

Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-----------------KHHGRSSTK 352
             VR  A  +  +L  LH+N++ H DLKPENIL                  K    +S +
Sbjct: 258 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 317

Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
           V DFGS+ F+++   T + +R YR PE+IL   ++ P D+WS GCIL E   G  LF   
Sbjct: 318 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 377

Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
           +  + L  M ++LG  P  ++ ++++ KYF     +    S    +DGR V         
Sbjct: 378 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENS----SDGRYV--------- 424

Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527
            K      K +       +     + ++R L +DP+ R+T A+AL HP+ +   P
Sbjct: 425 -KENCKPLKSY-MLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTP 477


>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
          Length = 616

 Score =  180 bits (456), Expect = 4e-45
 Identities = 114/343 (33%), Positives = 179/343 (52%), Gaps = 33/343 (9%)

Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
           Y++++++GKG+FG+VA+ +     + VA+K+++N+   +R    E+++L  ++  D   +
Sbjct: 11  YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70

Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
            +VI  LE F       + FELL  +L+E  K+N F     + +R     +L +L  L +
Sbjct: 71  -HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKE 129

Query: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLYT---YIQSRFYRAPEIILG 383
             IIH DLKPENI+L    R     KVIDFGS+    +  Y    YIQSRFYRAPEI+LG
Sbjct: 130 LAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLG 189

Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443
             +   +D+WS GC++AEL  G PL+PG +E DQ+  + E  G+P P LL  + +A +F 
Sbjct: 190 LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFF 249

Query: 444 NSKGIPRYCS---VTTQAD--------------------GRVVLVGGRSRRGKKRGPPGS 480
                P   +   + + AD                     ++  V G S   +   P   
Sbjct: 250 KRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFP--- 306

Query: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523
            D     +  D    +E +KR L W+   R++P+ ALRHP++S
Sbjct: 307 -DREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVS 348


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score =  162 bits (409), Expect = 1e-39
 Identities = 109/349 (31%), Positives = 171/349 (48%), Gaps = 21/349 (6%)

Query: 190  YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHR 248
            + DA+G Y     + L  RY V    G+G F  V R  D+ +  Q VA+K++RN +   +
Sbjct: 668  WTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQK 727

Query: 249  QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGF 307
               +E+  L+ L   D     + + +   F  + H+C+ FE LS++L E++KK  K  G 
Sbjct: 728  TGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGL 787

Query: 308  SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 367
             ++ VR ++Q +  +L  L +  I+H D+KP+NIL+ +  ++  K+ DFGS+        
Sbjct: 788  HIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILV-NESKTILKLCDFGSASHVADNDI 846

Query: 368  T-YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426
            T Y+ SRFYRAPEII+G  Y   ID+WS GC L EL TG+ LFPG+     L   M+L G
Sbjct: 847  TPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKG 906

Query: 427  MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486
              P K++ +        +      Y  V    +   V V              +KD    
Sbjct: 907  KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN--------PTKDLLAD 958

Query: 487  LKGCDD---------YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV 526
            L GC           +   + L + L  DP+ R++  QAL+H +I + +
Sbjct: 959  LIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007


>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
          Length = 364

 Score =  150 bits (380), Expect = 2e-36
 Identities = 110/350 (31%), Positives = 177/350 (50%), Gaps = 47/350 (13%)

Query: 182 IGGPNNGGY-DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240
           + GP  G Y  + +     VP+     R + L+ +G G++G V   YD +LRQ VA+K +
Sbjct: 1   MSGPRAGFYRQELNKTVWEVPQ-----RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL 55

Query: 241 RN--EKRFH-RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYE 297
               +   H R+   E+R+L+HLK ++  G ++V     S    + V +   L+  DL  
Sbjct: 56  SRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN 115

Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357
           ++K    Q  S + V+     +L+ L  +H   IIH DLKP N+ +        +++DFG
Sbjct: 116 IVK---CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED--CELRILDFG 170

Query: 358 SSCFEYQKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416
            +    +++  Y+ +R+YRAPEI+L    Y+  +DIWS GCI+AELL G+ LFPG D  D
Sbjct: 171 LARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 230

Query: 417 QLACMMELLGMPPPKLLEQ--SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474
           QL  +ME++G P P++L +  S+ A+ +I S  +P                         
Sbjct: 231 QLKRIMEVVGTPSPEVLAKISSEHARTYIQS--LP------------------------- 263

Query: 475 RGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524
             P   KD  +  +G +  L I+ L R L  D   R++ A+AL H + S+
Sbjct: 264 --PMPQKDLSSIFRGANP-LAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310


>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
           sapiens]
          Length = 360

 Score =  143 bits (361), Expect = 4e-34
 Identities = 99/321 (30%), Positives = 158/321 (49%), Gaps = 37/321 (11%)

Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN--EKRFH-RQAAEEIRILEHLKKQD 264
           RY+ L  +G G++G V   +D K    VA+K +    +   H ++   E+R+L+H+K ++
Sbjct: 23  RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82

Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324
             G ++V     S    N V +   L+  DL  ++K  K     VQ +      IL+ L 
Sbjct: 83  VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQILRGLK 139

Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG- 383
            +H   IIH DLKP N+ +        K++DFG +     ++  Y+ +R+YRAPEI+L  
Sbjct: 140 YIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNW 197

Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443
             Y+  +DIWS GCI+AELLTG+ LFPG D  DQL  ++ L+G P  +LL++       I
Sbjct: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK-------I 250

Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503
           +S+    Y    TQ                        ++     G +  L ++ L++ L
Sbjct: 251 SSESARNYIQSLTQMP--------------------KMNFANVFIGANP-LAVDLLEKML 289

Query: 504 HWDPSARLTPAQALRHPWISK 524
             D   R+T AQAL H + ++
Sbjct: 290 VLDSDKRITAAQALAHAYFAQ 310


>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
           sapiens]
          Length = 297

 Score =  140 bits (352), Expect = 4e-33
 Identities = 86/244 (35%), Positives = 135/244 (55%), Gaps = 11/244 (4%)

Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN--EKRFH-RQAAEEIRILEHLKKQD 264
           RY+ L  +G G++G V   +D K    VA+K +    +   H ++   E+R+L+H+K ++
Sbjct: 23  RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82

Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324
             G ++V     S    N V +   L+  DL  ++K  K     VQ +      IL+ L 
Sbjct: 83  VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQILRGLK 139

Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG- 383
            +H   IIH DLKP N+ +        K++DFG +     ++  Y+ +R+YRAPEI+L  
Sbjct: 140 YIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNW 197

Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ--SKRAKY 441
             Y+  +DIWS GCI+AELLTG+ LFPG D  DQL  ++ L+G P  +LL++  S+ A+ 
Sbjct: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257

Query: 442 FINS 445
           +I S
Sbjct: 258 YIQS 261


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,295,670
Number of Sequences: 37866
Number of extensions: 1353525
Number of successful extensions: 6271
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 593
Number of HSP's successfully gapped in prelim test: 198
Number of HSP's that attempted gapping in prelim test: 4097
Number of HSP's gapped (non-prelim): 1254
length of query: 588
length of database: 18,247,518
effective HSP length: 108
effective length of query: 480
effective length of database: 14,157,990
effective search space: 6795835200
effective search space used: 6795835200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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