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Search of human proteins with 50511945
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50511945 cajalin 2 isoform a [Homo sapiens]
(1248 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50511945 cajalin 2 isoform a [Homo sapiens] 2522 0.0
gi|50511947 cajalin 2 isoform b [Homo sapiens] 842 0.0
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 569 e-162
gi|10047134 cajalin 2 isoform c [Homo sapiens] 476 e-134
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 213 7e-55
gi|18079216 CASK interacting protein 1 [Homo sapiens] 206 1e-52
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens] 162 2e-39
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 130 1e-29
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 130 1e-29
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 130 1e-29
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 130 1e-29
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 130 1e-29
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 129 1e-29
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 123 1e-27
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 123 1e-27
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 123 1e-27
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 123 1e-27
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 120 1e-26
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 114 4e-25
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 114 4e-25
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 113 1e-24
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 113 1e-24
gi|34304381 inversin isoform a [Homo sapiens] 112 2e-24
gi|34304379 inversin isoform b [Homo sapiens] 112 2e-24
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 111 4e-24
gi|30348954 mindbomb homolog 1 [Homo sapiens] 111 5e-24
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 111 5e-24
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 110 6e-24
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 110 6e-24
gi|110431370 espin [Homo sapiens] 110 8e-24
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 2522 bits (6537), Expect = 0.0
Identities = 1248/1248 (100%), Positives = 1248/1248 (100%)
Query: 1 MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY 60
MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY
Sbjct: 1 MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY 60
Query: 61 TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR 120
TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR
Sbjct: 61 TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR 120
Query: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI 180
VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI
Sbjct: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI 180
Query: 181 ISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVD 240
ISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVD
Sbjct: 181 ISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVD 240
Query: 241 VVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQE 300
VVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQE
Sbjct: 241 VVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQE 300
Query: 301 DATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNL 360
DATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNL
Sbjct: 301 DATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNL 360
Query: 361 SKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGFP 420
SKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGFP
Sbjct: 361 SKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGFP 420
Query: 421 MLAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRTD 480
MLAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRTD
Sbjct: 421 MLAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRTD 480
Query: 481 NASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFHR 540
NASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFHR
Sbjct: 481 NASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFHR 540
Query: 541 MNHNQEYFEINTSTGCTSFTASPPASPPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEY 600
MNHNQEYFEINTSTGCTSFTASPPASPPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEY
Sbjct: 541 MNHNQEYFEINTSTGCTSFTASPPASPPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEY 600
Query: 601 DPGQFAGLLHGSSPACESPENPFHLYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEPL 660
DPGQFAGLLHGSSPACESPENPFHLYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEPL
Sbjct: 601 DPGQFAGLLHGSSPACESPENPFHLYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEPL 660
Query: 661 VKKIKPKVVSRTIFHKKSNQLENHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIR 720
VKKIKPKVVSRTIFHKKSNQLENHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIR
Sbjct: 661 VKKIKPKVVSRTIFHKKSNQLENHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIR 720
Query: 721 SLPKALIDMHLSKSVSKSDSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEW 780
SLPKALIDMHLSKSVSKSDSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEW
Sbjct: 721 SLPKALIDMHLSKSVSKSDSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEW 780
Query: 781 EEIDKIMSSIDVGINNELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQ 840
EEIDKIMSSIDVGINNELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQ
Sbjct: 781 EEIDKIMSSIDVGINNELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQ 840
Query: 841 FMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGD 900
FMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGD
Sbjct: 841 FMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGD 900
Query: 901 YTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSIT 960
YTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSIT
Sbjct: 901 YTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSIT 960
Query: 961 LREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQM 1020
LREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQM
Sbjct: 961 LREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQM 1020
Query: 1021 AQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTES 1080
AQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTES
Sbjct: 1021 AQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTES 1080
Query: 1081 TQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDP 1140
TQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDP
Sbjct: 1081 TQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDP 1140
Query: 1141 EDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSST 1200
EDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSST
Sbjct: 1141 EDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSST 1200
Query: 1201 LPESFENKPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHTEEALRKF 1248
LPESFENKPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHTEEALRKF
Sbjct: 1201 LPESFENKPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHTEEALRKF 1248
>gi|50511947 cajalin 2 isoform b [Homo sapiens]
Length = 510
Score = 842 bits (2175), Expect = 0.0
Identities = 422/460 (91%), Positives = 425/460 (92%), Gaps = 32/460 (6%)
Query: 806 TRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQR 865
T PRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQR
Sbjct: 32 TGPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQR 91
Query: 866 ILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELI 925
ILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELI
Sbjct: 92 ILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELI 151
Query: 926 NVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTG 985
NVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTG
Sbjct: 152 NVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTG 211
Query: 986 GSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQ----------------------- 1022
GSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQ
Sbjct: 212 GSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQSSVCEIWTNQNAGFPFSAIHQVH 271
Query: 1023 -TGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTEST 1081
TGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTEST
Sbjct: 272 NTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTEST 331
Query: 1082 QDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPE 1141
QDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPE
Sbjct: 332 QDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPE 391
Query: 1142 DLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL 1201
DLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL
Sbjct: 392 DLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTL 451
Query: 1202 PESFENKPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHT 1241
PESFENKPSKPIPKPRVSIRKSV + +PSE+ T
Sbjct: 452 PESFENKPSKPIPKPRVSIRKSVQI--------DPSEQKT 483
>gi|140161500 ankyrin repeat and sterile alpha motif domain containing
1 [Homo sapiens]
Length = 1134
Score = 569 bits (1466), Expect = e-162
Identities = 329/668 (49%), Positives = 430/668 (64%), Gaps = 43/668 (6%)
Query: 569 TSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEYDPGQFAGLLHGSSPACESPENPFHLYGK 628
T V + K + + QD + P QF+GLLHGSSP CE ++PF L
Sbjct: 463 TKKVVLVDGKTKDHRRSSSSRSQDSAEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLL-- 520
Query: 629 REQCEKGQD-------EVSLANSPLPFKQSPIE--NNSEPLVKKIKPKVVSRTIFHKKSN 679
C GQ + + + + +++ + S+P +V T ++
Sbjct: 521 ---CTAGQSHPDGSPQQGACHKASMQLEETGVHAPGASQPSALDQSKRVGYLTGLPTTNS 577
Query: 680 QLENHTIVGTRSTR-SGSRNGDQWVMNAGGFVERACTLGRIRSLPKALIDMHLSKSVSKS 738
+ T+ T S G+ GD+ G RA + PKA ++ LS+S+SKS
Sbjct: 578 RSHPETLTHTASPHPGGAEEGDR-----SGARSRAPPTSK----PKA--ELKLSRSLSKS 626
Query: 739 DSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEWEEIDKIMSSIDVGIN--N 796
DSDL+ E + + SES + K E++PSF SEW+EI+KIMSSI GI+
Sbjct: 627 DSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDEIEKIMSSIGEGIDFSQ 686
Query: 797 ELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIG 856
E ++++G T Q+VG+WLESIGL QYE+ L+ NGFD+V F+GSNVME+QDL +IG
Sbjct: 687 ERQKISGLRTLE----QSVGEWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIG 742
Query: 857 ILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLL 916
I + HR+++LQA + LPK++ +G+DG P SV WLDS+ L DY +FL +GY+S+D +
Sbjct: 743 ISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTV 802
Query: 917 KKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPS 976
K +WE+EL+NVLK+ L+GHRKRI+ASL DR +++PPQKPPR LR Q S
Sbjct: 803 KNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQKPPRFSQLR---CQDLLSQTSSP 859
Query: 977 LSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPP 1036
LSQ+ TG S D+ ++ GD RRR+++ D S+ ER Q + E +TLRPP
Sbjct: 860 LSQNDSCTGRSADL--LLPPGDTGRRRHDSLHDPAAPSRAERFRIQE-EHREAKLTLRPP 916
Query: 1037 NEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKST 1096
+ A PVQ WQH PEKLIF+SC Y+A YLGSMLIK+LRGTESTQDACAKMR KST
Sbjct: 917 SLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMR----KST 972
Query: 1097 EQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSN 1156
E MKK+PTIILS++YKGVKFIDA+NKN+IAEHEIRNISCAAQDPEDL TFAYITKDL+++
Sbjct: 973 EHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTS 1032
Query: 1157 HHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKG-GHSSTLPESFENKPSKPIPK 1215
HHYCHVF+ DVNL YEIILTLGQAFEVAYQLALQA+K ++ E E K SKP+PK
Sbjct: 1033 HHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRATGASAAEMIETKSSKPVPK 1092
Query: 1216 PRVSIRKS 1223
PRV +RKS
Sbjct: 1093 PRVGVRKS 1100
Score = 444 bits (1141), Expect = e-124
Identities = 233/382 (60%), Positives = 293/382 (76%), Gaps = 26/382 (6%)
Query: 1 MGKDQELLEAARTGNVALVEKLLSGRK----------------GGILGGGSGPL-----P 39
MGK+QELLEAARTG++ VEKLLSG++ GG GGG G L P
Sbjct: 1 MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP 60
Query: 40 LSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLA 99
LS+LLS+WRGPNVNC DS+GYT LHHAALNGHKD+V LL+ +A TNVAD+KG +P+HLA
Sbjct: 61 LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
Query: 100 AWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNS 159
AWKGD +IV++LIH GPSH+RVNEQNN+NETALHCAAQYGH+EVV VLLEELTDPT+RN+
Sbjct: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
Query: 160 KLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMD 219
K ETPLDLAALYGRL VVKM+++AHPNL+SCNT+KHTPLHLAARNGHKAVVQVLL+AGMD
Sbjct: 181 KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240
Query: 220 VSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIAT 279
+ QTE GSALHEAALFGK DVV++LL G D NIKD+ G T LD ++E PSQKS QIA
Sbjct: 241 SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAA 300
Query: 280 LLQEYLEGVGRSTVLEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQ 339
L+++++ G RST + V + + + S ++S SQK++ + V +++L+ +
Sbjct: 301 LIEDHMTG-KRST---KEVDKTPPPQPPLISSMDSISQKSQGD-VEKAVTELIIDFDANA 355
Query: 340 EKDYSFEDLCHTISDHYLDNLS 361
E++ +E L + IS H LD+++
Sbjct: 356 EEEGPYEALYNAISCHSLDSMA 377
>gi|10047134 cajalin 2 isoform c [Homo sapiens]
Length = 414
Score = 476 bits (1224), Expect = e-134
Identities = 260/380 (68%), Positives = 287/380 (75%), Gaps = 24/380 (6%)
Query: 888 SVAEWLDSIELGDYTKAFLINGYTSMDLL-KKIWEVELINVLKINLIGHRKRILASLG-- 944
+V +WL+SI L Y + NG+ ++ + + E + + + I GHR+RIL ++
Sbjct: 40 TVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLL 99
Query: 945 --------DRLHDDPPQKPPRSITLREPSGNHTPPQL-----SPSLSQSTYTTGGSLDVP 991
D H + SI L G++T L S L + + ++V
Sbjct: 100 PKMRPIGHDGYHPTSVAEWLDSIEL----GDYTKAFLINGYTSMDLLKKIWEVE-LINVL 154
Query: 992 HIIMQGDARR---RRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEATASTPVQYW 1048
I + G +R + DD P+ +TGDWGEPSITLRPPNEATASTPVQYW
Sbjct: 155 KINLIGHRKRILASLGDRLHDDPPQKPPRSITLRTGDWGEPSITLRPPNEATASTPVQYW 214
Query: 1049 QHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILS 1108
QHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILS
Sbjct: 215 QHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILS 274
Query: 1109 VSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDV 1168
VSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDV
Sbjct: 275 VSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDV 334
Query: 1169 NLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVDLLH 1228
NLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVDLLH
Sbjct: 335 NLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVDLLH 394
Query: 1229 ASHTGQEPSERHTEEALRKF 1248
ASHTGQEPSERHTEEALRKF
Sbjct: 395 ASHTGQEPSERHTEEALRKF 414
Score = 324 bits (830), Expect = 4e-88
Identities = 161/171 (94%), Positives = 161/171 (94%), Gaps = 5/171 (2%)
Query: 806 TRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQR 865
T PRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQR
Sbjct: 32 TGPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQR 91
Query: 866 ILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELI 925
ILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELI
Sbjct: 92 ILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELI 151
Query: 926 NVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLR-----EPSGNHTPP 971
NVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLR EPS PP
Sbjct: 152 NVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLRTGDWGEPSITLRPP 202
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 213 bits (543), Expect = 7e-55
Identities = 116/292 (39%), Positives = 188/292 (64%), Gaps = 22/292 (7%)
Query: 1 MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY 60
MG++Q+L+ A + G+V V+KL++ K + LL + NVN D+ G+
Sbjct: 1 MGREQDLILAVKNGDVTGVQKLVAKVKA----------TKTKLLGSTKRLNVNYQDADGF 50
Query: 61 TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR 120
+ALHHAAL G +++ LL+ +A+ ++ D+ G P+H AAW+G +E V++L+ + +
Sbjct: 51 SALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLR---ASAA 107
Query: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI 180
VN + + + LH AAQYGH EV +LL+ ++P + N +TPLDLA +GRL+V +++
Sbjct: 108 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 167
Query: 181 ISAHPNLM--------SCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHE 232
+++H + C+ TPLHLAA+NGH+ V++ LL AG++++ QT+ G+ALHE
Sbjct: 168 LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHE 227
Query: 233 AALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEH-PSQKSLQIATLLQE 283
AAL+GK +VVR+LLE G+D NI+++ +T LDI+ + SQ S +I LL+E
Sbjct: 228 AALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLRE 279
Score = 62.4 bits (150), Expect = 3e-09
Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 8/129 (6%)
Query: 813 QTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQL 872
Q + WL L Y H + G+D + M +DL IG+ GHR++I I
Sbjct: 492 QAIHNWLSEFQLEGYTAHFLQAGYDVPTI---SRMTPEDLTAIGVTKPGHRKKIASEIAQ 548
Query: 873 LPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKI-WEVELINVLKIN 931
L + Y PT + EWL ++ L Y K + +GY SM L+ + WE + + +N
Sbjct: 549 LSIAEWL--PSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVN 604
Query: 932 LIGHRKRIL 940
+GH+K+++
Sbjct: 605 KLGHQKKLM 613
Score = 45.4 bits (106), Expect = 3e-04
Identities = 19/61 (31%), Positives = 40/61 (65%), Gaps = 2/61 (3%)
Query: 817 QWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKM 876
+WL ++GLPQY L+++G+D++ + E+ L EIG+ GH+++++ ++ L ++
Sbjct: 565 EWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVNKLGHQKKLMLGVKRLAEL 622
Query: 877 R 877
R
Sbjct: 623 R 623
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 206 bits (524), Expect = 1e-52
Identities = 115/292 (39%), Positives = 189/292 (64%), Gaps = 22/292 (7%)
Query: 1 MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY 60
MGK+QEL++A + +V ++LL + G + LL + NVN D G+
Sbjct: 1 MGKEQELVQAVKAEDVGTAQRLLQRPRPG----------KAKLLGSTKKINVNFQDPDGF 50
Query: 61 TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR 120
+ALHHAALNG+ +++ LL+ +A+ ++ DNKG P+H AAW+G E +K+++ G S
Sbjct: 51 SALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAG---SA 107
Query: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI 180
VN ++E LH AAQ+GH +V +LL+ ++P + ++ +TPLDLA +GR+ VV+++
Sbjct: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
Query: 181 ISAHPNLMSCNTRKH--------TPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHE 232
+S++ R +PLHLAA+NGH ++++LL+AG+D++ QT+ G+ALHE
Sbjct: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHE 227
Query: 233 AALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEH-PSQKSLQIATLLQE 283
AAL GK +VVR+LL++GI+A+++++ +T LDI+ + SQ S +I LL+E
Sbjct: 228 AALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLRE 279
Score = 59.7 bits (143), Expect = 2e-08
Identities = 40/134 (29%), Positives = 67/134 (50%), Gaps = 12/134 (8%)
Query: 813 QTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQL 872
+ V QWL + L Y + ++ G+D + M +DL IG+ GHR++I I
Sbjct: 475 EAVSQWLTAFQLQLYAPNFISAGYDLPTI---SRMTPEDLTAIGVTKPGHRKKIAAEISG 531
Query: 873 L--PKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKI-WEVELINVLK 929
L P P + P ++A WL I L Y K + NGY ++D + I WE + +
Sbjct: 532 LSIPDWLP----EHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWED--LQEIG 585
Query: 930 INLIGHRKRILASL 943
I +GH+K+++ ++
Sbjct: 586 ITKLGHQKKLMLAV 599
Score = 48.5 bits (114), Expect = 4e-05
Identities = 24/67 (35%), Positives = 40/67 (59%), Gaps = 2/67 (2%)
Query: 818 WLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMR 877
WL IGL QY L+ NG++N+ F+ E DL EIGI GH+++++ A++ L +++
Sbjct: 549 WLSMIGLAQYYKVLVDNGYENIDFITDITWE--DLQEIGITKLGHQKKLMLAVRKLAELQ 606
Query: 878 PIGHDGY 884
+ Y
Sbjct: 607 KAEYAKY 613
Score = 32.0 bits (71), Expect = 3.8
Identities = 22/89 (24%), Positives = 41/89 (46%), Gaps = 3/89 (3%)
Query: 874 PKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLI 933
PK +G +V++WL + +L Y F+ GY + + E + + +
Sbjct: 462 PKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISR--MTPEDLTAIGVTKP 519
Query: 934 GHRKRILASL-GDRLHDDPPQKPPRSITL 961
GHRK+I A + G + D P+ P ++ +
Sbjct: 520 GHRKKIAAEISGLSIPDWLPEHKPANLAV 548
>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
Length = 1120
Score = 162 bits (410), Expect = 2e-39
Identities = 85/198 (42%), Positives = 134/198 (67%), Gaps = 12/198 (6%)
Query: 95 PIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP 154
P+H AAW+G +E V++L+ + + VN + + + LH AAQYGH EV +LL+ ++P
Sbjct: 3 PLHYAAWQGRLEPVRLLLR---ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP 59
Query: 155 TIRNSKLETPLDLAALYGRLRVVKMIISAHPNLM--------SCNTRKHTPLHLAARNGH 206
+ N +TPLDLA +GRL+V ++++++H + C+ TPLHLAA+NGH
Sbjct: 60 CLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGH 119
Query: 207 KAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDIL 266
+ V++ LL AG++++ QT+ G+ALHEAAL+GK +VVR+LLE G+D NI+++ +T LDI+
Sbjct: 120 REVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
Query: 267 KEH-PSQKSLQIATLLQE 283
+ SQ S +I LL+E
Sbjct: 180 NQFTTSQASREIKQLLRE 197
Score = 62.4 bits (150), Expect = 3e-09
Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 8/129 (6%)
Query: 813 QTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQL 872
Q + WL L Y H + G+D + M +DL IG+ GHR++I I
Sbjct: 410 QAIHNWLSEFQLEGYTAHFLQAGYDVPTI---SRMTPEDLTAIGVTKPGHRKKIASEIAQ 466
Query: 873 LPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKI-WEVELINVLKIN 931
L + Y PT + EWL ++ L Y K + +GY SM L+ + WE + + +N
Sbjct: 467 LSIAEWL--PSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVN 522
Query: 932 LIGHRKRIL 940
+GH+K+++
Sbjct: 523 KLGHQKKLM 531
Score = 61.2 bits (147), Expect = 6e-09
Identities = 51/177 (28%), Positives = 83/177 (46%), Gaps = 16/177 (9%)
Query: 52 VNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKIL 111
VN G LH AA GH ++ LLQ++++ + + P+ LA G +++ ++L
Sbjct: 26 VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 85
Query: 112 IHHGPSHSRVNEQNNENE--------TALHCAAQYGHSEVVAVLLEELTDPTIRNSKLET 163
++ SH V E + T LH AA+ GH EV+ LL + R +K T
Sbjct: 86 LN---SHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGT 141
Query: 164 PLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHL----AARNGHKAVVQVLLEA 216
L AALYG+ VV++++ ++ NT T L + + + Q+L EA
Sbjct: 142 ALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREA 198
Score = 45.4 bits (106), Expect = 3e-04
Identities = 19/61 (31%), Positives = 40/61 (65%), Gaps = 2/61 (3%)
Query: 817 QWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKM 876
+WL ++GLPQY L+++G+D++ + E+ L EIG+ GH+++++ ++ L ++
Sbjct: 483 EWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVNKLGHQKKLMLGVKRLAEL 540
Query: 877 R 877
R
Sbjct: 541 R 541
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 130 bits (326), Expect = 1e-29
Identities = 85/235 (36%), Positives = 117/235 (49%), Gaps = 7/235 (2%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
+G N +G+T LH A H ++ LL+ AS + G P+H+A++ G + I
Sbjct: 393 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 452
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDL 167
VK L+ G S N N + ET LH AA+ GH+EV LL+ + +TPL
Sbjct: 453 VKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 509
Query: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
AA G +VK+++ + N T HTPLH+AAR GH V LLE +C T+KG
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
Query: 228 -SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
+ LH AA +GKV V +LLE N G T L + H +L I LL
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH---NNLDIVKLL 621
Score = 120 bits (302), Expect = 6e-27
Identities = 96/271 (35%), Positives = 144/271 (53%), Gaps = 18/271 (6%)
Query: 10 AARTGNV----ALVEKLLSG----RKGGI---LGGGSGPLPLSNLLSIWRGPNVNCTDSS 58
AAR G+V AL+EK S +KG + G + ++ LL + R + N +
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHPNAAGKN 601
Query: 59 GYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSH 118
G T LH A + + DIV LL S + GY P+H+AA + VE+ + L+ +G S
Sbjct: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS- 660
Query: 119 SRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVK 178
N ++ + T LH AAQ GH+E+VA+LL + + + N TPL L A G + V
Sbjct: 661 --ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVAD 718
Query: 179 MIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALF 236
++I H ++ TR +TPLH+A+ G+ +V+ LL+ DV+ +T+ G S LH+AA
Sbjct: 719 VLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 777
Query: 237 GKVDVVRVLLETGIDANIKDSLGRTVLDILK 267
G D+V +LL+ G N S G T L I K
Sbjct: 778 GHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808
Score = 115 bits (287), Expect = 3e-25
Identities = 87/275 (31%), Positives = 134/275 (48%), Gaps = 43/275 (15%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G +++ SG T LH A+ GH IV LLQ AS NV++ K P+H+AA G E+
Sbjct: 427 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 486
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTI------------ 156
K L+ + ++VN + +++T LHCAA+ GH+ +V +LLE +P +
Sbjct: 487 KYLLQN---KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 543
Query: 157 -RNSKLET--------------------PLDLAALYGRLRVVKMII--SAHPNLMSCNTR 193
R +ET PL +AA YG++RV ++++ AHPN N
Sbjct: 544 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 603
Query: 194 KHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDA 252
TPLH+A + + +V++LL G G + LH AA +V+V R LL+ G A
Sbjct: 604 --TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 661
Query: 253 NIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEG 287
N + G T L + + + +A LL + G
Sbjct: 662 NAESVQGVTPLHLAAQEGHAE--MVALLLSKQANG 694
Score = 104 bits (260), Expect = 5e-22
Identities = 72/233 (30%), Positives = 119/233 (51%), Gaps = 29/233 (12%)
Query: 55 TDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHH 114
T G TALH AAL G ++V +L+ Y A+ N KG+ P+++AA + +E+VK L+ +
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Query: 115 GPSHSRVNE-----------QNNENET---------------ALHCAAQYGHSEVVAVLL 148
G + + E Q +EN ALH AA+ + AVLL
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 226
Query: 149 EELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKA 208
+ +P + + TPL +AA Y L V +++++ ++ TPLH+A+R G+
Sbjct: 227 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 286
Query: 209 VVQVLLEAGMDVSCQT-EKGSALHEAALFGKVDVVRVLLETG--IDANIKDSL 258
+V++LL+ G + +T ++ + LH AA G V + +LL+ G I A K+ L
Sbjct: 287 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 339
Score = 103 bits (256), Expect = 1e-21
Identities = 72/215 (33%), Positives = 111/215 (51%), Gaps = 14/215 (6%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
RG +VN T +G T LH A+ G+ +V LL A P+H AA G V I
Sbjct: 261 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 320
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLE---ELTDPTIRNSKLETP 164
+IL+ HG + + + + +H AAQ H + V +LL+ E+ D T+ + TP
Sbjct: 321 SEILLDHG---APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TP 374
Query: 165 LDLAALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSC 222
L +AA G RV K+++ A PN + N TPLH+A + H V+++LL+ G +
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 223 QTEKG-SALHEAALFGKVDVVRVLLETGIDANIKD 256
TE G + LH A+ G + +V+ LL+ G N+ +
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 467
Score = 94.7 bits (234), Expect = 5e-19
Identities = 73/255 (28%), Positives = 113/255 (44%), Gaps = 27/255 (10%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALN 69
A+R GNV +V LL RG + T LH AA N
Sbjct: 279 ASRRGNVIMVRLLLD-----------------------RGAQIETKTKDELTPLHCAARN 315
Query: 70 GHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENE 129
GH I LL + A G PIH+AA ++ V++L+ + + +++ ++
Sbjct: 316 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD---AEIDDITLDHL 372
Query: 130 TALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMS 189
T LH AA GH V VLL++ P R TPL +A +RV+++++ ++ +
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 190 CNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEK-GSALHEAALFGKVDVVRVLLET 248
TPLH+A+ GH +V+ LL+ G + K + LH AA G +V + LL+
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 492
Query: 249 GIDANIKDSLGRTVL 263
N K +T L
Sbjct: 493 KAKVNAKAKDDQTPL 507
Score = 94.0 bits (232), Expect = 8e-19
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 8/218 (3%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G ++N + +G LH A+ GH +V++LL E KG +H+AA G E+V
Sbjct: 68 GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 127
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+ L+++G + VN Q+ + T L+ AAQ H EVV LLE + + TPL +A
Sbjct: 128 RELVNYG---ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
G VV +I N + + LH+AARN VLL+ + ++ G
Sbjct: 185 LQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 240
Query: 228 SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
+ LH AA + ++V ++LL G N G T L I
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 278
Score = 85.1 bits (209), Expect = 4e-16
Identities = 56/167 (33%), Positives = 84/167 (50%), Gaps = 7/167 (4%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G + N G T LH AA GH ++V LL +A+ N+ + G P+HL A +G V +
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 717
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+LI HG V+ T LH A+ YG+ ++V LL+ D + +PL A
Sbjct: 718 DVLIKHGVM---VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 774
Query: 169 ALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVL 213
A G +V +++ A PN +S + TPL +A R G+ +V VL
Sbjct: 775 AQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAKRLGYISVTDVL 819
Score = 73.9 bits (180), Expect = 9e-13
Identities = 66/221 (29%), Positives = 99/221 (44%), Gaps = 9/221 (4%)
Query: 61 TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR 120
T+ AA +G+ D L L+ N + G +HLA+ +G V++V L+H
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
Query: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI 180
++ N TALH AA G EVV L+ + ++ K TPL +AA L VVK +
Sbjct: 107 TTKKGN---TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163
Query: 181 ISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVD 240
+ N TPL +A + GH+ VV L+ G + ALH AA
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTR 220
Query: 241 VVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
VLL+ + ++ G T L I + ++L +A LL
Sbjct: 221 TAAVLLQNDPNPDVLSKTGFTPLHIAAHY---ENLNVAQLL 258
Score = 54.7 bits (130), Expect = 5e-07
Identities = 49/189 (25%), Positives = 88/189 (46%), Gaps = 3/189 (1%)
Query: 117 SHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRV 176
+ SR ++ + T+ AA+ G+ + L D N L LA+ G +++
Sbjct: 34 NRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 93
Query: 177 VKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAAL 235
V ++ L + + +T LH+AA G VV+ L+ G +V+ Q++KG + L+ AA
Sbjct: 94 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 153
Query: 236 FGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLE 295
++VV+ LLE G + N+ G T L + + + +A L+ +G R L
Sbjct: 154 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN--VVAHLINYGTKGKVRLPALH 211
Query: 296 EPVQEDATQ 304
+ D T+
Sbjct: 212 IAARNDDTR 220
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 130 bits (326), Expect = 1e-29
Identities = 85/235 (36%), Positives = 117/235 (49%), Gaps = 7/235 (2%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
+G N +G+T LH A H ++ LL+ AS + G P+H+A++ G + I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDL 167
VK L+ G S N N + ET LH AA+ GH+EV LL+ + +TPL
Sbjct: 420 VKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Query: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
AA G +VK+++ + N T HTPLH+AAR GH V LLE +C T+KG
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 228 -SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
+ LH AA +GKV V +LLE N G T L + H +L I LL
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH---NNLDIVKLL 588
Score = 120 bits (302), Expect = 6e-27
Identities = 96/271 (35%), Positives = 144/271 (53%), Gaps = 18/271 (6%)
Query: 10 AARTGNV----ALVEKLLSG----RKGGI---LGGGSGPLPLSNLLSIWRGPNVNCTDSS 58
AAR G+V AL+EK S +KG + G + ++ LL + R + N +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHPNAAGKN 568
Query: 59 GYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSH 118
G T LH A + + DIV LL S + GY P+H+AA + VE+ + L+ +G S
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS- 627
Query: 119 SRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVK 178
N ++ + T LH AAQ GH+E+VA+LL + + + N TPL L A G + V
Sbjct: 628 --ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVAD 685
Query: 179 MIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALF 236
++I H ++ TR +TPLH+A+ G+ +V+ LL+ DV+ +T+ G S LH+AA
Sbjct: 686 VLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 237 GKVDVVRVLLETGIDANIKDSLGRTVLDILK 267
G D+V +LL+ G N S G T L I K
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 115 bits (287), Expect = 3e-25
Identities = 87/275 (31%), Positives = 134/275 (48%), Gaps = 43/275 (15%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G +++ SG T LH A+ GH IV LLQ AS NV++ K P+H+AA G E+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTI------------ 156
K L+ + ++VN + +++T LHCAA+ GH+ +V +LLE +P +
Sbjct: 454 KYLLQN---KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 157 -RNSKLET--------------------PLDLAALYGRLRVVKMII--SAHPNLMSCNTR 193
R +ET PL +AA YG++RV ++++ AHPN N
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 194 KHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDA 252
TPLH+A + + +V++LL G G + LH AA +V+V R LL+ G A
Sbjct: 571 --TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 253 NIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEG 287
N + G T L + + + +A LL + G
Sbjct: 629 NAESVQGVTPLHLAAQEGHAE--MVALLLSKQANG 661
Score = 104 bits (260), Expect = 5e-22
Identities = 72/233 (30%), Positives = 119/233 (51%), Gaps = 29/233 (12%)
Query: 55 TDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHH 114
T G TALH AAL G ++V +L+ Y A+ N KG+ P+++AA + +E+VK L+ +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 115 GPSHSRVNE-----------QNNENET---------------ALHCAAQYGHSEVVAVLL 148
G + + E Q +EN ALH AA+ + AVLL
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193
Query: 149 EELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKA 208
+ +P + + TPL +AA Y L V +++++ ++ TPLH+A+R G+
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253
Query: 209 VVQVLLEAGMDVSCQT-EKGSALHEAALFGKVDVVRVLLETG--IDANIKDSL 258
+V++LL+ G + +T ++ + LH AA G V + +LL+ G I A K+ L
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Score = 103 bits (256), Expect = 1e-21
Identities = 72/215 (33%), Positives = 111/215 (51%), Gaps = 14/215 (6%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
RG +VN T +G T LH A+ G+ +V LL A P+H AA G V I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLE---ELTDPTIRNSKLETP 164
+IL+ HG + + + + +H AAQ H + V +LL+ E+ D T+ + TP
Sbjct: 288 SEILLDHG---APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TP 341
Query: 165 LDLAALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSC 222
L +AA G RV K+++ A PN + N TPLH+A + H V+++LL+ G +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 223 QTEKG-SALHEAALFGKVDVVRVLLETGIDANIKD 256
TE G + LH A+ G + +V+ LL+ G N+ +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 94.7 bits (234), Expect = 5e-19
Identities = 73/255 (28%), Positives = 113/255 (44%), Gaps = 27/255 (10%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALN 69
A+R GNV +V LL RG + T LH AA N
Sbjct: 246 ASRRGNVIMVRLLLD-----------------------RGAQIETKTKDELTPLHCAARN 282
Query: 70 GHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENE 129
GH I LL + A G PIH+AA ++ V++L+ + + +++ ++
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD---AEIDDITLDHL 339
Query: 130 TALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMS 189
T LH AA GH V VLL++ P R TPL +A +RV+++++ ++ +
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 190 CNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEK-GSALHEAALFGKVDVVRVLLET 248
TPLH+A+ GH +V+ LL+ G + K + LH AA G +V + LL+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 249 GIDANIKDSLGRTVL 263
N K +T L
Sbjct: 460 KAKVNAKAKDDQTPL 474
Score = 94.0 bits (232), Expect = 8e-19
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 8/218 (3%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G ++N + +G LH A+ GH +V++LL E KG +H+AA G E+V
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+ L+++G + VN Q+ + T L+ AAQ H EVV LLE + + TPL +A
Sbjct: 95 RELVNYG---ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
G VV +I N + + LH+AARN VLL+ + ++ G
Sbjct: 152 LQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 207
Query: 228 SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
+ LH AA + ++V ++LL G N G T L I
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Score = 85.1 bits (209), Expect = 4e-16
Identities = 56/167 (33%), Positives = 84/167 (50%), Gaps = 7/167 (4%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G + N G T LH AA GH ++V LL +A+ N+ + G P+HL A +G V +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+LI HG V+ T LH A+ YG+ ++V LL+ D + +PL A
Sbjct: 685 DVLIKHGVM---VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 169 ALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVL 213
A G +V +++ A PN +S + TPL +A R G+ +V VL
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAKRLGYISVTDVL 786
Score = 75.1 bits (183), Expect = 4e-13
Identities = 67/231 (29%), Positives = 103/231 (44%), Gaps = 9/231 (3%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
+V ++ T+ AA +G+ D L L+ N + G +HLA+ +G V++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+H ++ N TALH AA G EVV L+ + ++ K TPL +AA
Sbjct: 64 LLHKEIILETTTKKGN---TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSAL 230
L VVK ++ N TPL +A + GH+ VV L+ G + AL
Sbjct: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PAL 177
Query: 231 HEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
H AA VLL+ + ++ G T L I + ++L +A LL
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY---ENLNVAQLL 225
Score = 52.4 bits (124), Expect = 3e-06
Identities = 46/171 (26%), Positives = 80/171 (46%), Gaps = 3/171 (1%)
Query: 135 AAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRK 194
AA+ G+ + L D N L LA+ G +++V ++ L + +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 195 HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDAN 253
+T LH+AA G VV+ L+ G +V+ Q++KG + L+ AA ++VV+ LLE G + N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 254 IKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQ 304
+ G T L + + + +A L+ +G R L + D T+
Sbjct: 139 VATEDGFTPLAVALQQGHEN--VVAHLINYGTKGKVRLPALHIAARNDDTR 187
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 130 bits (326), Expect = 1e-29
Identities = 85/235 (36%), Positives = 117/235 (49%), Gaps = 7/235 (2%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
+G N +G+T LH A H ++ LL+ AS + G P+H+A++ G + I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDL 167
VK L+ G S N N + ET LH AA+ GH+EV LL+ + +TPL
Sbjct: 420 VKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Query: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
AA G +VK+++ + N T HTPLH+AAR GH V LLE +C T+KG
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 228 -SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
+ LH AA +GKV V +LLE N G T L + H +L I LL
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH---NNLDIVKLL 588
Score = 120 bits (302), Expect = 6e-27
Identities = 96/271 (35%), Positives = 144/271 (53%), Gaps = 18/271 (6%)
Query: 10 AARTGNV----ALVEKLLSG----RKGGI---LGGGSGPLPLSNLLSIWRGPNVNCTDSS 58
AAR G+V AL+EK S +KG + G + ++ LL + R + N +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHPNAAGKN 568
Query: 59 GYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSH 118
G T LH A + + DIV LL S + GY P+H+AA + VE+ + L+ +G S
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS- 627
Query: 119 SRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVK 178
N ++ + T LH AAQ GH+E+VA+LL + + + N TPL L A G + V
Sbjct: 628 --ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVAD 685
Query: 179 MIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALF 236
++I H ++ TR +TPLH+A+ G+ +V+ LL+ DV+ +T+ G S LH+AA
Sbjct: 686 VLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 237 GKVDVVRVLLETGIDANIKDSLGRTVLDILK 267
G D+V +LL+ G N S G T L I K
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 115 bits (287), Expect = 3e-25
Identities = 87/275 (31%), Positives = 134/275 (48%), Gaps = 43/275 (15%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G +++ SG T LH A+ GH IV LLQ AS NV++ K P+H+AA G E+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTI------------ 156
K L+ + ++VN + +++T LHCAA+ GH+ +V +LLE +P +
Sbjct: 454 KYLLQN---KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 157 -RNSKLET--------------------PLDLAALYGRLRVVKMII--SAHPNLMSCNTR 193
R +ET PL +AA YG++RV ++++ AHPN N
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 194 KHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDA 252
TPLH+A + + +V++LL G G + LH AA +V+V R LL+ G A
Sbjct: 571 --TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 253 NIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEG 287
N + G T L + + + +A LL + G
Sbjct: 629 NAESVQGVTPLHLAAQEGHAE--MVALLLSKQANG 661
Score = 104 bits (260), Expect = 5e-22
Identities = 72/233 (30%), Positives = 119/233 (51%), Gaps = 29/233 (12%)
Query: 55 TDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHH 114
T G TALH AAL G ++V +L+ Y A+ N KG+ P+++AA + +E+VK L+ +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 115 GPSHSRVNE-----------QNNENET---------------ALHCAAQYGHSEVVAVLL 148
G + + E Q +EN ALH AA+ + AVLL
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193
Query: 149 EELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKA 208
+ +P + + TPL +AA Y L V +++++ ++ TPLH+A+R G+
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253
Query: 209 VVQVLLEAGMDVSCQT-EKGSALHEAALFGKVDVVRVLLETG--IDANIKDSL 258
+V++LL+ G + +T ++ + LH AA G V + +LL+ G I A K+ L
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Score = 103 bits (256), Expect = 1e-21
Identities = 72/215 (33%), Positives = 111/215 (51%), Gaps = 14/215 (6%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
RG +VN T +G T LH A+ G+ +V LL A P+H AA G V I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLE---ELTDPTIRNSKLETP 164
+IL+ HG + + + + +H AAQ H + V +LL+ E+ D T+ + TP
Sbjct: 288 SEILLDHG---APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TP 341
Query: 165 LDLAALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSC 222
L +AA G RV K+++ A PN + N TPLH+A + H V+++LL+ G +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 223 QTEKG-SALHEAALFGKVDVVRVLLETGIDANIKD 256
TE G + LH A+ G + +V+ LL+ G N+ +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 94.7 bits (234), Expect = 5e-19
Identities = 73/255 (28%), Positives = 113/255 (44%), Gaps = 27/255 (10%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALN 69
A+R GNV +V LL RG + T LH AA N
Sbjct: 246 ASRRGNVIMVRLLLD-----------------------RGAQIETKTKDELTPLHCAARN 282
Query: 70 GHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENE 129
GH I LL + A G PIH+AA ++ V++L+ + + +++ ++
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD---AEIDDITLDHL 339
Query: 130 TALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMS 189
T LH AA GH V VLL++ P R TPL +A +RV+++++ ++ +
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 190 CNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEK-GSALHEAALFGKVDVVRVLLET 248
TPLH+A+ GH +V+ LL+ G + K + LH AA G +V + LL+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 249 GIDANIKDSLGRTVL 263
N K +T L
Sbjct: 460 KAKVNAKAKDDQTPL 474
Score = 94.0 bits (232), Expect = 8e-19
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 8/218 (3%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G ++N + +G LH A+ GH +V++LL E KG +H+AA G E+V
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+ L+++G + VN Q+ + T L+ AAQ H EVV LLE + + TPL +A
Sbjct: 95 RELVNYG---ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
G VV +I N + + LH+AARN VLL+ + ++ G
Sbjct: 152 LQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 207
Query: 228 SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
+ LH AA + ++V ++LL G N G T L I
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Score = 85.1 bits (209), Expect = 4e-16
Identities = 56/167 (33%), Positives = 84/167 (50%), Gaps = 7/167 (4%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G + N G T LH AA GH ++V LL +A+ N+ + G P+HL A +G V +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+LI HG V+ T LH A+ YG+ ++V LL+ D + +PL A
Sbjct: 685 DVLIKHGVM---VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 169 ALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVL 213
A G +V +++ A PN +S + TPL +A R G+ +V VL
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAKRLGYISVTDVL 786
Score = 75.1 bits (183), Expect = 4e-13
Identities = 67/231 (29%), Positives = 103/231 (44%), Gaps = 9/231 (3%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
+V ++ T+ AA +G+ D L L+ N + G +HLA+ +G V++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+H ++ N TALH AA G EVV L+ + ++ K TPL +AA
Sbjct: 64 LLHKEIILETTTKKGN---TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSAL 230
L VVK ++ N TPL +A + GH+ VV L+ G + AL
Sbjct: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PAL 177
Query: 231 HEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
H AA VLL+ + ++ G T L I + ++L +A LL
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY---ENLNVAQLL 225
Score = 52.4 bits (124), Expect = 3e-06
Identities = 46/171 (26%), Positives = 80/171 (46%), Gaps = 3/171 (1%)
Query: 135 AAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRK 194
AA+ G+ + L D N L LA+ G +++V ++ L + +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 195 HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDAN 253
+T LH+AA G VV+ L+ G +V+ Q++KG + L+ AA ++VV+ LLE G + N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 254 IKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQ 304
+ G T L + + + +A L+ +G R L + D T+
Sbjct: 139 VATEDGFTPLAVALQQGHEN--VVAHLINYGTKGKVRLPALHIAARNDDTR 187
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 130 bits (326), Expect = 1e-29
Identities = 85/235 (36%), Positives = 117/235 (49%), Gaps = 7/235 (2%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
+G N +G+T LH A H ++ LL+ AS + G P+H+A++ G + I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDL 167
VK L+ G S N N + ET LH AA+ GH+EV LL+ + +TPL
Sbjct: 420 VKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Query: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
AA G +VK+++ + N T HTPLH+AAR GH V LLE +C T+KG
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 228 -SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
+ LH AA +GKV V +LLE N G T L + H +L I LL
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH---NNLDIVKLL 588
Score = 120 bits (302), Expect = 6e-27
Identities = 96/271 (35%), Positives = 144/271 (53%), Gaps = 18/271 (6%)
Query: 10 AARTGNV----ALVEKLLSG----RKGGI---LGGGSGPLPLSNLLSIWRGPNVNCTDSS 58
AAR G+V AL+EK S +KG + G + ++ LL + R + N +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHPNAAGKN 568
Query: 59 GYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSH 118
G T LH A + + DIV LL S + GY P+H+AA + VE+ + L+ +G S
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS- 627
Query: 119 SRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVK 178
N ++ + T LH AAQ GH+E+VA+LL + + + N TPL L A G + V
Sbjct: 628 --ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVAD 685
Query: 179 MIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALF 236
++I H ++ TR +TPLH+A+ G+ +V+ LL+ DV+ +T+ G S LH+AA
Sbjct: 686 VLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 237 GKVDVVRVLLETGIDANIKDSLGRTVLDILK 267
G D+V +LL+ G N S G T L I K
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 115 bits (287), Expect = 3e-25
Identities = 87/275 (31%), Positives = 134/275 (48%), Gaps = 43/275 (15%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G +++ SG T LH A+ GH IV LLQ AS NV++ K P+H+AA G E+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTI------------ 156
K L+ + ++VN + +++T LHCAA+ GH+ +V +LLE +P +
Sbjct: 454 KYLLQN---KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 157 -RNSKLET--------------------PLDLAALYGRLRVVKMII--SAHPNLMSCNTR 193
R +ET PL +AA YG++RV ++++ AHPN N
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 194 KHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDA 252
TPLH+A + + +V++LL G G + LH AA +V+V R LL+ G A
Sbjct: 571 --TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 253 NIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEG 287
N + G T L + + + +A LL + G
Sbjct: 629 NAESVQGVTPLHLAAQEGHAE--MVALLLSKQANG 661
Score = 104 bits (260), Expect = 5e-22
Identities = 72/233 (30%), Positives = 119/233 (51%), Gaps = 29/233 (12%)
Query: 55 TDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHH 114
T G TALH AAL G ++V +L+ Y A+ N KG+ P+++AA + +E+VK L+ +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 115 GPSHSRVNE-----------QNNENET---------------ALHCAAQYGHSEVVAVLL 148
G + + E Q +EN ALH AA+ + AVLL
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193
Query: 149 EELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKA 208
+ +P + + TPL +AA Y L V +++++ ++ TPLH+A+R G+
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253
Query: 209 VVQVLLEAGMDVSCQT-EKGSALHEAALFGKVDVVRVLLETG--IDANIKDSL 258
+V++LL+ G + +T ++ + LH AA G V + +LL+ G I A K+ L
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Score = 103 bits (256), Expect = 1e-21
Identities = 72/215 (33%), Positives = 111/215 (51%), Gaps = 14/215 (6%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
RG +VN T +G T LH A+ G+ +V LL A P+H AA G V I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLE---ELTDPTIRNSKLETP 164
+IL+ HG + + + + +H AAQ H + V +LL+ E+ D T+ + TP
Sbjct: 288 SEILLDHG---APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TP 341
Query: 165 LDLAALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSC 222
L +AA G RV K+++ A PN + N TPLH+A + H V+++LL+ G +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 223 QTEKG-SALHEAALFGKVDVVRVLLETGIDANIKD 256
TE G + LH A+ G + +V+ LL+ G N+ +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 94.7 bits (234), Expect = 5e-19
Identities = 73/255 (28%), Positives = 113/255 (44%), Gaps = 27/255 (10%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALN 69
A+R GNV +V LL RG + T LH AA N
Sbjct: 246 ASRRGNVIMVRLLLD-----------------------RGAQIETKTKDELTPLHCAARN 282
Query: 70 GHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENE 129
GH I LL + A G PIH+AA ++ V++L+ + + +++ ++
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD---AEIDDITLDHL 339
Query: 130 TALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMS 189
T LH AA GH V VLL++ P R TPL +A +RV+++++ ++ +
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 190 CNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEK-GSALHEAALFGKVDVVRVLLET 248
TPLH+A+ GH +V+ LL+ G + K + LH AA G +V + LL+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 249 GIDANIKDSLGRTVL 263
N K +T L
Sbjct: 460 KAKVNAKAKDDQTPL 474
Score = 94.0 bits (232), Expect = 8e-19
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 8/218 (3%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G ++N + +G LH A+ GH +V++LL E KG +H+AA G E+V
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+ L+++G + VN Q+ + T L+ AAQ H EVV LLE + + TPL +A
Sbjct: 95 RELVNYG---ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
G VV +I N + + LH+AARN VLL+ + ++ G
Sbjct: 152 LQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 207
Query: 228 SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
+ LH AA + ++V ++LL G N G T L I
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Score = 85.1 bits (209), Expect = 4e-16
Identities = 56/167 (33%), Positives = 84/167 (50%), Gaps = 7/167 (4%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G + N G T LH AA GH ++V LL +A+ N+ + G P+HL A +G V +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+LI HG V+ T LH A+ YG+ ++V LL+ D + +PL A
Sbjct: 685 DVLIKHGVM---VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 169 ALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVL 213
A G +V +++ A PN +S + TPL +A R G+ +V VL
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAKRLGYISVTDVL 786
Score = 75.1 bits (183), Expect = 4e-13
Identities = 67/231 (29%), Positives = 103/231 (44%), Gaps = 9/231 (3%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
+V ++ T+ AA +G+ D L L+ N + G +HLA+ +G V++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+H ++ N TALH AA G EVV L+ + ++ K TPL +AA
Sbjct: 64 LLHKEIILETTTKKGN---TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSAL 230
L VVK ++ N TPL +A + GH+ VV L+ G + AL
Sbjct: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PAL 177
Query: 231 HEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
H AA VLL+ + ++ G T L I + ++L +A LL
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY---ENLNVAQLL 225
Score = 52.4 bits (124), Expect = 3e-06
Identities = 46/171 (26%), Positives = 80/171 (46%), Gaps = 3/171 (1%)
Query: 135 AAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRK 194
AA+ G+ + L D N L LA+ G +++V ++ L + +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 195 HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDAN 253
+T LH+AA G VV+ L+ G +V+ Q++KG + L+ AA ++VV+ LLE G + N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 254 IKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQ 304
+ G T L + + + +A L+ +G R L + D T+
Sbjct: 139 VATEDGFTPLAVALQQGHEN--VVAHLINYGTKGKVRLPALHIAARNDDTR 187
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 130 bits (326), Expect = 1e-29
Identities = 85/235 (36%), Positives = 117/235 (49%), Gaps = 7/235 (2%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
+G N +G+T LH A H ++ LL+ AS + G P+H+A++ G + I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDL 167
VK L+ G S N N + ET LH AA+ GH+EV LL+ + +TPL
Sbjct: 420 VKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Query: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
AA G +VK+++ + N T HTPLH+AAR GH V LLE +C T+KG
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 228 -SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
+ LH AA +GKV V +LLE N G T L + H +L I LL
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH---NNLDIVKLL 588
Score = 120 bits (302), Expect = 6e-27
Identities = 96/271 (35%), Positives = 144/271 (53%), Gaps = 18/271 (6%)
Query: 10 AARTGNV----ALVEKLLSG----RKGGI---LGGGSGPLPLSNLLSIWRGPNVNCTDSS 58
AAR G+V AL+EK S +KG + G + ++ LL + R + N +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL-LERDAHPNAAGKN 568
Query: 59 GYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSH 118
G T LH A + + DIV LL S + GY P+H+AA + VE+ + L+ +G S
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS- 627
Query: 119 SRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVK 178
N ++ + T LH AAQ GH+E+VA+LL + + + N TPL L A G + V
Sbjct: 628 --ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVAD 685
Query: 179 MIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALF 236
++I H ++ TR +TPLH+A+ G+ +V+ LL+ DV+ +T+ G S LH+AA
Sbjct: 686 VLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 237 GKVDVVRVLLETGIDANIKDSLGRTVLDILK 267
G D+V +LL+ G N S G T L I K
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 115 bits (287), Expect = 3e-25
Identities = 87/275 (31%), Positives = 134/275 (48%), Gaps = 43/275 (15%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G +++ SG T LH A+ GH IV LLQ AS NV++ K P+H+AA G E+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTI------------ 156
K L+ + ++VN + +++T LHCAA+ GH+ +V +LLE +P +
Sbjct: 454 KYLLQN---KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 157 -RNSKLET--------------------PLDLAALYGRLRVVKMII--SAHPNLMSCNTR 193
R +ET PL +AA YG++RV ++++ AHPN N
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 194 KHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDA 252
TPLH+A + + +V++LL G G + LH AA +V+V R LL+ G A
Sbjct: 571 --TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 253 NIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEG 287
N + G T L + + + +A LL + G
Sbjct: 629 NAESVQGVTPLHLAAQEGHAE--MVALLLSKQANG 661
Score = 104 bits (260), Expect = 5e-22
Identities = 72/233 (30%), Positives = 119/233 (51%), Gaps = 29/233 (12%)
Query: 55 TDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHH 114
T G TALH AAL G ++V +L+ Y A+ N KG+ P+++AA + +E+VK L+ +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 115 GPSHSRVNE-----------QNNENET---------------ALHCAAQYGHSEVVAVLL 148
G + + E Q +EN ALH AA+ + AVLL
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193
Query: 149 EELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKA 208
+ +P + + TPL +AA Y L V +++++ ++ TPLH+A+R G+
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI 253
Query: 209 VVQVLLEAGMDVSCQT-EKGSALHEAALFGKVDVVRVLLETG--IDANIKDSL 258
+V++LL+ G + +T ++ + LH AA G V + +LL+ G I A K+ L
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Score = 103 bits (256), Expect = 1e-21
Identities = 72/215 (33%), Positives = 111/215 (51%), Gaps = 14/215 (6%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
RG +VN T +G T LH A+ G+ +V LL A P+H AA G V I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLE---ELTDPTIRNSKLETP 164
+IL+ HG + + + + +H AAQ H + V +LL+ E+ D T+ + TP
Sbjct: 288 SEILLDHG---APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TP 341
Query: 165 LDLAALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSC 222
L +AA G RV K+++ A PN + N TPLH+A + H V+++LL+ G +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 223 QTEKG-SALHEAALFGKVDVVRVLLETGIDANIKD 256
TE G + LH A+ G + +V+ LL+ G N+ +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 94.7 bits (234), Expect = 5e-19
Identities = 73/255 (28%), Positives = 113/255 (44%), Gaps = 27/255 (10%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALN 69
A+R GNV +V LL RG + T LH AA N
Sbjct: 246 ASRRGNVIMVRLLLD-----------------------RGAQIETKTKDELTPLHCAARN 282
Query: 70 GHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENE 129
GH I LL + A G PIH+AA ++ V++L+ + + +++ ++
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD---AEIDDITLDHL 339
Query: 130 TALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMS 189
T LH AA GH V VLL++ P R TPL +A +RV+++++ ++ +
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 190 CNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEK-GSALHEAALFGKVDVVRVLLET 248
TPLH+A+ GH +V+ LL+ G + K + LH AA G +V + LL+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 249 GIDANIKDSLGRTVL 263
N K +T L
Sbjct: 460 KAKVNAKAKDDQTPL 474
Score = 94.0 bits (232), Expect = 8e-19
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 8/218 (3%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G ++N + +G LH A+ GH +V++LL E KG +H+AA G E+V
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+ L+++G + VN Q+ + T L+ AAQ H EVV LLE + + TPL +A
Sbjct: 95 RELVNYG---ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
G VV +I N + + LH+AARN VLL+ + ++ G
Sbjct: 152 LQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 207
Query: 228 SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
+ LH AA + ++V ++LL G N G T L I
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Score = 85.1 bits (209), Expect = 4e-16
Identities = 56/167 (33%), Positives = 84/167 (50%), Gaps = 7/167 (4%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G + N G T LH AA GH ++V LL +A+ N+ + G P+HL A +G V +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+LI HG V+ T LH A+ YG+ ++V LL+ D + +PL A
Sbjct: 685 DVLIKHGVM---VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 169 ALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVL 213
A G +V +++ A PN +S + TPL +A R G+ +V VL
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAKRLGYISVTDVL 786
Score = 75.1 bits (183), Expect = 4e-13
Identities = 67/231 (29%), Positives = 103/231 (44%), Gaps = 9/231 (3%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
+V ++ T+ AA +G+ D L L+ N + G +HLA+ +G V++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+H ++ N TALH AA G EVV L+ + ++ K TPL +AA
Sbjct: 64 LLHKEIILETTTKKGN---TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSAL 230
L VVK ++ N TPL +A + GH+ VV L+ G + AL
Sbjct: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PAL 177
Query: 231 HEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
H AA VLL+ + ++ G T L I + ++L +A LL
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY---ENLNVAQLL 225
Score = 52.4 bits (124), Expect = 3e-06
Identities = 46/171 (26%), Positives = 80/171 (46%), Gaps = 3/171 (1%)
Query: 135 AAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRK 194
AA+ G+ + L D N L LA+ G +++V ++ L + +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 195 HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDAN 253
+T LH+AA G VV+ L+ G +V+ Q++KG + L+ AA ++VV+ LLE G + N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 254 IKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQ 304
+ G T L + + + +A L+ +G R L + D T+
Sbjct: 139 VATEDGFTPLAVALQQGHEN--VVAHLINYGTKGKVRLPALHIAARNDDTR 187
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 129 bits (325), Expect = 1e-29
Identities = 78/224 (34%), Positives = 119/224 (53%), Gaps = 4/224 (1%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
N N +G+T LH A ++ LL++ AS G PIH+AA+ G V IV
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+HHG S N N ETALH AA+ G +EVV L+++ + +TPL ++A
Sbjct: 452 LMHHGASP---NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SA 229
G+ +V+ ++ + + T +TPLHL+AR GH+ V LL+ G +S T+KG +
Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
Query: 230 LHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQK 273
LH AA +GK++V +LL+ + G T L + + +QK
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQK 612
Score = 116 bits (291), Expect = 1e-25
Identities = 74/218 (33%), Positives = 110/218 (50%), Gaps = 4/218 (1%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G V T LH +A G DIV +LLQ AS N A GY P+HL+A +G ++
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
L+ HG S S ++ T LH AA+YG EV +LL++ P TPL +A
Sbjct: 549 AFLLDHGASLSITTKKGF---TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVA 605
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
A Y +V +++ + + +TPLH+AA+ + LLE G D + T +G
Sbjct: 606 AHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI 665
Query: 228 SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
+++H AA G VD+V +LL + N+ + G T L +
Sbjct: 666 ASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHL 703
Score = 116 bits (290), Expect = 2e-25
Identities = 104/414 (25%), Positives = 186/414 (44%), Gaps = 35/414 (8%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
+G + N +SGYT LH +A GH+D+ LL + AS ++ KG+ P+H+AA G +E+
Sbjct: 521 QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEV 580
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDL 167
+L+ S + T LH AA Y + +V +LL++ P TPL +
Sbjct: 581 ANLLLQKSASPDAAGK---SGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHI 637
Query: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
AA ++ + ++ + + + +HLAA+ GH +V +LL +V+ + G
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Query: 228 -SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLE 286
+ LH AA +V+V VL+ G + + +G T L + + + K + LLQ +
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF--LLQHSAK 755
Query: 287 GVGRSTVLEEPVQEDATQ-ETHISSPVESPSQKTKSETVTGELS----------KLLDEI 335
++ P+ + A Q THI + + + TV G + ++D +
Sbjct: 756 VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Query: 336 KLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGE----VEE 391
K+ E+ + T+++ + N+ + E L + + + ++ LS GE VEE
Sbjct: 816 KIVTEETMT----TTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEE 871
Query: 392 ED-----DDENTCGPSGLWEA---LTPCNGCR--NLGFPMLAQESYPKKRNYTM 435
+ D + GP L E P G +LG + S+ R+YT+
Sbjct: 872 GEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTL 925
Score = 110 bits (274), Expect = 1e-23
Identities = 78/268 (29%), Positives = 129/268 (48%), Gaps = 11/268 (4%)
Query: 44 LSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKG 103
L + G ++ SG T +H AA GH +IV +L+ + AS N + +G +H+AA G
Sbjct: 418 LLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG 477
Query: 104 DVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLET 163
E+V+ L+ G ++V + +++T LH +A+ G +++V LL++ P + T
Sbjct: 478 QAEVVRYLVQDG---AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYT 534
Query: 164 PLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQ 223
PL L+A G V ++ +L + TPLH+AA+ G V +LL+
Sbjct: 535 PLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAA 594
Query: 224 TEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQ 282
+ G + LH AA + V +LL+ G + G T L I + + + IAT L
Sbjct: 595 GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK---KNQMDIATTLL 651
Query: 283 EYLEGVGRSTVLEEPVQED--ATQETHI 308
EY G + V + + A QE H+
Sbjct: 652 EY--GADANAVTRQGIASVHLAAQEGHV 677
Score = 106 bits (264), Expect = 2e-22
Identities = 67/219 (30%), Positives = 109/219 (49%), Gaps = 4/219 (1%)
Query: 48 RGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
RG ++ G T LH A +GH+ +V LL A G P+H+A +
Sbjct: 290 RGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNC 349
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDL 167
V++L+ H V++ N+ TALH AA GH +V VLL++ +P + TPL +
Sbjct: 350 VQLLLQHNVP---VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406
Query: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
A R++V+++++ ++ + TP+H+AA GH +V L+ G + +G
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Query: 228 -SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
+ALH AA G+ +VVR L++ G K +T L I
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHI 505
Score = 101 bits (251), Expect = 5e-21
Identities = 74/247 (29%), Positives = 111/247 (44%), Gaps = 14/247 (5%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLS----------NLLSIWRGPNVNCTDSSG 59
AA+ G + + LL G SG PL LL + +G + + +G
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 60 YTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHS 119
YT LH AA DI LL+Y A N +G +HLAA +G V++V +L+ ++
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR---NA 688
Query: 120 RVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKM 179
VN N T LH AAQ V VL+ + + TPL + YG +++V
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748
Query: 180 IISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGK 238
++ + + +TPLH AA+ GH ++ VLL+ + T G +AL A G
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGY 808
Query: 239 VDVVRVL 245
+ VV L
Sbjct: 809 ISVVDTL 815
Score = 99.0 bits (245), Expect = 3e-20
Identities = 64/202 (31%), Positives = 105/202 (51%), Gaps = 8/202 (3%)
Query: 46 IWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDV 105
I G ++N + +G ALH A+ GH ++V +LLQ EA+ + A KG +H+A+ G
Sbjct: 61 IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120
Query: 106 EIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPL 165
E+VK+L+ +G + VN Q+ T L+ AAQ H EVV LL+ ++ TPL
Sbjct: 121 EVVKVLVTNG---ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL 177
Query: 166 DLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTE 225
+A G +VV +++ + LH+AAR +LL+ + +++
Sbjct: 178 AVALQQGHDQVVSLLLENDTK----GKVRLPALHIAARKDDTKAAALLLQNDNNADVESK 233
Query: 226 KG-SALHEAALFGKVDVVRVLL 246
G + LH AA +G ++V +LL
Sbjct: 234 SGFTPLHIAAHYGNINVATLLL 255
Score = 90.9 bits (224), Expect = 7e-18
Identities = 78/281 (27%), Positives = 132/281 (46%), Gaps = 43/281 (15%)
Query: 10 AARTGNVALVEKLLSGRKGGILGG---GSGPLPLSNLLS--------IWRGPNVNCTDSS 58
A++ G+V +V +LL R+ + G+ L +++L + G NVN +
Sbjct: 81 ASKEGHVEVVSELLQ-REANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQN 139
Query: 59 GYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPS- 117
G+T L+ AA H ++V LL AS ++A G+ P+ +A +G ++V +L+ +
Sbjct: 140 GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKG 199
Query: 118 -------HSRVNE----------QNNENE--------TALHCAAQYGHSEVVAVLLEELT 152
H + QN+ N T LH AA YG+ V +LL
Sbjct: 200 KVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAA 259
Query: 153 --DPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVV 210
D T RN TPL +A+ G +VK+++ + + TPLH AR+GH+ VV
Sbjct: 260 AVDFTARNDI--TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 211 QVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGI 250
++LL+ + +T+ G S LH A ++ V++LL+ +
Sbjct: 318 EMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Score = 80.9 bits (198), Expect = 7e-15
Identities = 68/245 (27%), Positives = 112/245 (45%), Gaps = 16/245 (6%)
Query: 66 AALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQN 125
AA GH + L ++ N+ + G +HLA+ +G VE+V L+ + V+
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR---EANVDAAT 104
Query: 126 NENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHP 185
+ TALH A+ G +EVV VL+ + ++ TPL +AA L VVK ++
Sbjct: 105 KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
Query: 186 NLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVL 245
+ TPL +A + GH VV +LLE + ALH AA +L
Sbjct: 165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRL---PALHIAARKDDTKAAALL 221
Query: 246 LETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQE 305
L+ +A+++ G T L I + ++ +ATLL + R+ ++ + D T
Sbjct: 222 LQNDNNADVESKSGFTPLHIAAHY---GNINVATLL------LNRAAAVDFTARNDIT-P 271
Query: 306 THISS 310
H++S
Sbjct: 272 LHVAS 276
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 123 bits (309), Expect = 1e-27
Identities = 85/236 (36%), Positives = 126/236 (53%), Gaps = 11/236 (4%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
N N +G+T LH A ++ L++Y AS G PIH+AA+ G + IV +
Sbjct: 369 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 428
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ +G S N + ETALH AA+ G EVV LL R + +TPL +A+
Sbjct: 429 LLQNGASPDVTNIRG---ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
Query: 171 YGRLRVVKMIIS--AHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
G+ +V++++ AHP+ + T +TPLH++AR G V VLLEAG S T+KG
Sbjct: 486 LGKTEIVQLLLQHMAHPD--AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF 543
Query: 228 SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQE 283
+ LH AA +G +DV ++LL+ A+ G T L + + +QK +A LL E
Sbjct: 544 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK---VALLLLE 596
Score = 113 bits (282), Expect = 1e-24
Identities = 89/283 (31%), Positives = 139/283 (49%), Gaps = 26/283 (9%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPL--------SNLLSIW--RGPNVNCTDSSG 59
AA GNV + LL+ +G PL +N++ + RG ++ G
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 60 YTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHS 119
T LH AA +GH +V LL+ A G P+H+AA VE VK L+ H +
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH---KA 335
Query: 120 RVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKM 179
V++ + TALH AA GH V +LL++ +P R TPL +A R++V+++
Sbjct: 336 PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMEL 395
Query: 180 IISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGK 238
++ ++ + TP+H+AA GH +V +LL+ G +G +ALH AA G+
Sbjct: 396 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 455
Query: 239 VDVVRVLLETG--IDA---------NIKDSLGRT-VLDILKEH 269
V+VVR LL G +DA +I LG+T ++ +L +H
Sbjct: 456 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Score = 109 bits (273), Expect = 1e-23
Identities = 75/247 (30%), Positives = 117/247 (47%), Gaps = 14/247 (5%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLS----------NLLSIWRGPNVNCTDSSG 59
AA+ G++ + + LL R G +G PL LL + +G + + T +G
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 60 YTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHS 119
YT LH AA I LL Y A TN+ +G P+HLA+ +G ++V +L+ G +
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG---A 665
Query: 120 RVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKM 179
++ T+LH AAQ V +L + D TPL +A YG +++V
Sbjct: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
Query: 180 IISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGK 238
++ N+ + +TPLH AA+ GH ++ VLL+ G + T G +AL A G
Sbjct: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
Query: 239 VDVVRVL 245
+ VV L
Sbjct: 786 ISVVDTL 792
Score = 107 bits (267), Expect = 7e-23
Identities = 83/289 (28%), Positives = 129/289 (44%), Gaps = 39/289 (13%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G ++ SG T +H AA GH +IVL LLQ AS +V + +G +H+AA G VE+V
Sbjct: 400 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 459
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP-------------- 154
+ L+ +G + V+ + E +T LH A++ G +E+V +LL+ + P
Sbjct: 460 RCLLRNG---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 516
Query: 155 -------------------TIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKH 195
++ K TPL +AA YG L V K+++ S
Sbjct: 517 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 576
Query: 196 TPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANI 254
TPLH+AA ++ V +LLE G + G + LH AA ++ + LL G + NI
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 255 KDSLGRTVLDILKE--HPSQKSLQIATLLQEYLEGVGRSTVLEEPVQED 301
G T L + + H +L + ++ T L QED
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 685
Score = 103 bits (258), Expect = 8e-22
Identities = 85/294 (28%), Positives = 134/294 (45%), Gaps = 59/294 (20%)
Query: 8 LEAARTGNVALVEKLLSGRKGGI--------------LGGGSGPLPLSNLLSIWRGPNVN 53
L AAR GN+ +K++ KGGI L G + L L + RG +V+
Sbjct: 15 LRAARAGNL---DKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQEL-LGRGSSVD 70
Query: 54 CTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIH 113
G TALH A+L G ++V L++ A+ N G+ P+++AA + +++VK L+
Sbjct: 71 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130
Query: 114 HGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLE----------- 162
+G + S E + T L A Q GH++ VA+LLE T +R L
Sbjct: 131 NGANQSTATE---DGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 187
Query: 163 --------------------------TPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHT 196
TPL +AA YG + V ++++ + T
Sbjct: 188 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 247
Query: 197 PLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETG 249
PLH+A++ G+ +V++LL+ G + +T G + LH AA G VV +LLE G
Sbjct: 248 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 301
Score = 76.6 bits (187), Expect = 1e-13
Identities = 68/250 (27%), Positives = 108/250 (43%), Gaps = 41/250 (16%)
Query: 66 AALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQN 125
AA G+ D V++ L+ N + G +HLAA +G V +V+ L+ G S V+
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS---VDSAT 73
Query: 126 NENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHP 185
+ TALH A+ G +EVV VL++E + ++ TPL +AA + VVK ++
Sbjct: 74 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 133
Query: 186 NLMSCNTRKHTPLHLAARNGHKAVVQVLLE------------------------------ 215
N + TPL +A + GH V +LLE
Sbjct: 134 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 193
Query: 216 -------AGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILK 267
+ M V+ TE G + LH AA +G V+V +LL G + G T L +
Sbjct: 194 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 253
Query: 268 EHPSQKSLQI 277
+ + +++
Sbjct: 254 KRGNTNMVKL 263
Score = 61.6 bits (148), Expect = 4e-09
Identities = 48/182 (26%), Positives = 91/182 (50%), Gaps = 3/182 (1%)
Query: 124 QNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISA 183
Q +++ + AA+ G+ + V L+ D N L LAA G + +V+ ++
Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
Query: 184 HPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVV 242
++ S + +T LH+A+ G VV+VL++ G +++ Q++ G + L+ AA +DVV
Sbjct: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
Query: 243 RVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDA 302
+ LLE G + + G T L + + ++ +A LL+ +G R L ++D
Sbjct: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQA--VAILLENDTKGKVRLPALHIAARKDD 183
Query: 303 TQ 304
T+
Sbjct: 184 TK 185
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 123 bits (309), Expect = 1e-27
Identities = 85/236 (36%), Positives = 126/236 (53%), Gaps = 11/236 (4%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
N N +G+T LH A ++ L++Y AS G PIH+AA+ G + IV +
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 449
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ +G S N + ETALH AA+ G EVV LL R + +TPL +A+
Sbjct: 450 LLQNGASPDVTNIRG---ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
Query: 171 YGRLRVVKMIIS--AHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
G+ +V++++ AHP+ + T +TPLH++AR G V VLLEAG S T+KG
Sbjct: 507 LGKTEIVQLLLQHMAHPD--AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF 564
Query: 228 SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQE 283
+ LH AA +G +DV ++LL+ A+ G T L + + +QK +A LL E
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK---VALLLLE 617
Score = 113 bits (282), Expect = 1e-24
Identities = 89/283 (31%), Positives = 139/283 (49%), Gaps = 26/283 (9%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPL--------SNLLSIW--RGPNVNCTDSSG 59
AA GNV + LL+ +G PL +N++ + RG ++ G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 60 YTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHS 119
T LH AA +GH +V LL+ A G P+H+AA VE VK L+ H +
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH---KA 356
Query: 120 RVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKM 179
V++ + TALH AA GH V +LL++ +P R TPL +A R++V+++
Sbjct: 357 PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMEL 416
Query: 180 IISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGK 238
++ ++ + TP+H+AA GH +V +LL+ G +G +ALH AA G+
Sbjct: 417 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 476
Query: 239 VDVVRVLLETG--IDA---------NIKDSLGRT-VLDILKEH 269
V+VVR LL G +DA +I LG+T ++ +L +H
Sbjct: 477 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 109 bits (273), Expect = 1e-23
Identities = 75/247 (30%), Positives = 117/247 (47%), Gaps = 14/247 (5%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLS----------NLLSIWRGPNVNCTDSSG 59
AA+ G++ + + LL R G +G PL LL + +G + + T +G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 60 YTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHS 119
YT LH AA I LL Y A TN+ +G P+HLA+ +G ++V +L+ G +
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG---A 686
Query: 120 RVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKM 179
++ T+LH AAQ V +L + D TPL +A YG +++V
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
Query: 180 IISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGK 238
++ N+ + +TPLH AA+ GH ++ VLL+ G + T G +AL A G
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Query: 239 VDVVRVL 245
+ VV L
Sbjct: 807 ISVVDTL 813
Score = 107 bits (267), Expect = 7e-23
Identities = 83/289 (28%), Positives = 129/289 (44%), Gaps = 39/289 (13%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G ++ SG T +H AA GH +IVL LLQ AS +V + +G +H+AA G VE+V
Sbjct: 421 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP-------------- 154
+ L+ +G + V+ + E +T LH A++ G +E+V +LL+ + P
Sbjct: 481 RCLLRNG---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Query: 155 -------------------TIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKH 195
++ K TPL +AA YG L V K+++ S
Sbjct: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 196 TPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANI 254
TPLH+AA ++ V +LLE G + G + LH AA ++ + LL G + NI
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 255 KDSLGRTVLDILKE--HPSQKSLQIATLLQEYLEGVGRSTVLEEPVQED 301
G T L + + H +L + ++ T L QED
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Score = 103 bits (258), Expect = 8e-22
Identities = 85/294 (28%), Positives = 134/294 (45%), Gaps = 59/294 (20%)
Query: 8 LEAARTGNVALVEKLLSGRKGGI--------------LGGGSGPLPLSNLLSIWRGPNVN 53
L AAR GN+ +K++ KGGI L G + L L + RG +V+
Sbjct: 36 LRAARAGNL---DKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQEL-LGRGSSVD 91
Query: 54 CTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIH 113
G TALH A+L G ++V L++ A+ N G+ P+++AA + +++VK L+
Sbjct: 92 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Query: 114 HGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLE----------- 162
+G + S E + T L A Q GH++ VA+LLE T +R L
Sbjct: 152 NGANQSTATE---DGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
Query: 163 --------------------------TPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHT 196
TPL +AA YG + V ++++ + T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268
Query: 197 PLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETG 249
PLH+A++ G+ +V++LL+ G + +T G + LH AA G VV +LLE G
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322
Score = 76.6 bits (187), Expect = 1e-13
Identities = 68/250 (27%), Positives = 108/250 (43%), Gaps = 41/250 (16%)
Query: 66 AALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQN 125
AA G+ D V++ L+ N + G +HLAA +G V +V+ L+ G S V+
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS---VDSAT 94
Query: 126 NENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHP 185
+ TALH A+ G +EVV VL++E + ++ TPL +AA + VVK ++
Sbjct: 95 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154
Query: 186 NLMSCNTRKHTPLHLAARNGHKAVVQVLLE------------------------------ 215
N + TPL +A + GH V +LLE
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 216 -------AGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILK 267
+ M V+ TE G + LH AA +G V+V +LL G + G T L +
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274
Query: 268 EHPSQKSLQI 277
+ + +++
Sbjct: 275 KRGNTNMVKL 284
Score = 64.3 bits (155), Expect = 7e-10
Identities = 50/192 (26%), Positives = 95/192 (49%), Gaps = 3/192 (1%)
Query: 114 HGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGR 173
+G S R + +++ + AA+ G+ + V L+ D N L LAA G
Sbjct: 17 NGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGH 76
Query: 174 LRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHE 232
+ +V+ ++ ++ S + +T LH+A+ G VV+VL++ G +++ Q++ G + L+
Sbjct: 77 VGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYM 136
Query: 233 AALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRST 292
AA +DVV+ LLE G + + G T L + + ++ +A LL+ +G R
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQA--VAILLENDTKGKVRLP 194
Query: 293 VLEEPVQEDATQ 304
L ++D T+
Sbjct: 195 ALHIAARKDDTK 206
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 123 bits (309), Expect = 1e-27
Identities = 85/236 (36%), Positives = 126/236 (53%), Gaps = 11/236 (4%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
N N +G+T LH A ++ L++Y AS G PIH+AA+ G + IV +
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 449
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ +G S N + ETALH AA+ G EVV LL R + +TPL +A+
Sbjct: 450 LLQNGASPDVTNIRG---ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
Query: 171 YGRLRVVKMIIS--AHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
G+ +V++++ AHP+ + T +TPLH++AR G V VLLEAG S T+KG
Sbjct: 507 LGKTEIVQLLLQHMAHPD--AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF 564
Query: 228 SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQE 283
+ LH AA +G +DV ++LL+ A+ G T L + + +QK +A LL E
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK---VALLLLE 617
Score = 113 bits (282), Expect = 1e-24
Identities = 89/283 (31%), Positives = 139/283 (49%), Gaps = 26/283 (9%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPL--------SNLLSIW--RGPNVNCTDSSG 59
AA GNV + LL+ +G PL +N++ + RG ++ G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 60 YTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHS 119
T LH AA +GH +V LL+ A G P+H+AA VE VK L+ H +
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH---KA 356
Query: 120 RVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKM 179
V++ + TALH AA GH V +LL++ +P R TPL +A R++V+++
Sbjct: 357 PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMEL 416
Query: 180 IISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGK 238
++ ++ + TP+H+AA GH +V +LL+ G +G +ALH AA G+
Sbjct: 417 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 476
Query: 239 VDVVRVLLETG--IDA---------NIKDSLGRT-VLDILKEH 269
V+VVR LL G +DA +I LG+T ++ +L +H
Sbjct: 477 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 109 bits (273), Expect = 1e-23
Identities = 75/247 (30%), Positives = 117/247 (47%), Gaps = 14/247 (5%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLS----------NLLSIWRGPNVNCTDSSG 59
AA+ G++ + + LL R G +G PL LL + +G + + T +G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 60 YTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHS 119
YT LH AA I LL Y A TN+ +G P+HLA+ +G ++V +L+ G +
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG---A 686
Query: 120 RVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKM 179
++ T+LH AAQ V +L + D TPL +A YG +++V
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
Query: 180 IISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGK 238
++ N+ + +TPLH AA+ GH ++ VLL+ G + T G +AL A G
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Query: 239 VDVVRVL 245
+ VV L
Sbjct: 807 ISVVDTL 813
Score = 107 bits (267), Expect = 7e-23
Identities = 83/289 (28%), Positives = 129/289 (44%), Gaps = 39/289 (13%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G ++ SG T +H AA GH +IVL LLQ AS +V + +G +H+AA G VE+V
Sbjct: 421 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP-------------- 154
+ L+ +G + V+ + E +T LH A++ G +E+V +LL+ + P
Sbjct: 481 RCLLRNG---ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Query: 155 -------------------TIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKH 195
++ K TPL +AA YG L V K+++ S
Sbjct: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 196 TPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANI 254
TPLH+AA ++ V +LLE G + G + LH AA ++ + LL G + NI
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 255 KDSLGRTVLDILKE--HPSQKSLQIATLLQEYLEGVGRSTVLEEPVQED 301
G T L + + H +L + ++ T L QED
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Score = 103 bits (258), Expect = 8e-22
Identities = 85/294 (28%), Positives = 134/294 (45%), Gaps = 59/294 (20%)
Query: 8 LEAARTGNVALVEKLLSGRKGGI--------------LGGGSGPLPLSNLLSIWRGPNVN 53
L AAR GN+ +K++ KGGI L G + L L + RG +V+
Sbjct: 36 LRAARAGNL---DKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQEL-LGRGSSVD 91
Query: 54 CTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIH 113
G TALH A+L G ++V L++ A+ N G+ P+++AA + +++VK L+
Sbjct: 92 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Query: 114 HGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLE----------- 162
+G + S E + T L A Q GH++ VA+LLE T +R L
Sbjct: 152 NGANQSTATE---DGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
Query: 163 --------------------------TPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHT 196
TPL +AA YG + V ++++ + T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268
Query: 197 PLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETG 249
PLH+A++ G+ +V++LL+ G + +T G + LH AA G VV +LLE G
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322
Score = 76.6 bits (187), Expect = 1e-13
Identities = 68/250 (27%), Positives = 108/250 (43%), Gaps = 41/250 (16%)
Query: 66 AALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQN 125
AA G+ D V++ L+ N + G +HLAA +G V +V+ L+ G S V+
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS---VDSAT 94
Query: 126 NENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHP 185
+ TALH A+ G +EVV VL++E + ++ TPL +AA + VVK ++
Sbjct: 95 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154
Query: 186 NLMSCNTRKHTPLHLAARNGHKAVVQVLLE------------------------------ 215
N + TPL +A + GH V +LLE
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 216 -------AGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILK 267
+ M V+ TE G + LH AA +G V+V +LL G + G T L +
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274
Query: 268 EHPSQKSLQI 277
+ + +++
Sbjct: 275 KRGNTNMVKL 284
Score = 64.3 bits (155), Expect = 7e-10
Identities = 50/192 (26%), Positives = 95/192 (49%), Gaps = 3/192 (1%)
Query: 114 HGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGR 173
+G S R + +++ + AA+ G+ + V L+ D N L LAA G
Sbjct: 17 NGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGH 76
Query: 174 LRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHE 232
+ +V+ ++ ++ S + +T LH+A+ G VV+VL++ G +++ Q++ G + L+
Sbjct: 77 VGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYM 136
Query: 233 AALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRST 292
AA +DVV+ LLE G + + G T L + + ++ +A LL+ +G R
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQA--VAILLENDTKGKVRLP 194
Query: 293 VLEEPVQEDATQ 304
L ++D T+
Sbjct: 195 ALHIAARKDDTK 206
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 123 bits (309), Expect = 1e-27
Identities = 84/224 (37%), Positives = 122/224 (54%), Gaps = 9/224 (4%)
Query: 46 IWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDV 105
++ G V+C D+ TAL AA GH+DIVL LLQ+ A N ADN+G + AA+ G
Sbjct: 631 LYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHR 690
Query: 106 EIVKILIHHGPSHSRVNEQNNENETALHCA-----AQYGHSEVVAVLLEELTDPTIRNSK 160
EIV+ L+ HG + VN ++ + TAL A A GH+ VV++L++ + +
Sbjct: 691 EIVEHLLDHG---AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKD 747
Query: 161 LETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDV 220
TPL +AA G + VV +++ ++ + TPL AA GH +VV LL G V
Sbjct: 748 GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807
Query: 221 -SCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
S +E + L A+ G V+VVR LL+ G+D N +D G T L
Sbjct: 808 DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPL 851
Score = 123 bits (309), Expect = 1e-27
Identities = 131/489 (26%), Positives = 207/489 (42%), Gaps = 88/489 (17%)
Query: 7 LLEAARTGNVALVEKLL-----------SGRKGGILGGGSGPLPLSNLLSIWRGPNVNCT 55
LL AA G+ ++V LL GR + G + + L + RG + N
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL-LDRGLDENHR 843
Query: 56 DSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHG 115
D +G+T LH AA GH+ I L++ A TN DN G P LA+ +G + V+IL+
Sbjct: 844 DDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE-- 901
Query: 116 PSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTD---------PTIRNSKLETPLD 166
+ S ++++ + AL AA GH ++V +L D PT+ LE L
Sbjct: 902 -NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960
Query: 167 LAALY------------------------GRLRVVKMIISAHPNLMSCNTRKHTPLHLAA 202
+A + G + +V+++I+ H ++ + + K + L AA
Sbjct: 961 MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA 1020
Query: 203 RNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRT 261
GH VVQ+L+E G V +G +AL AA G +DVV+VLLE G D N D GRT
Sbjct: 1021 WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 1080
Query: 262 VLDILKEHPSQKSLQIATLLQEY----LEGVGRS---TVLEEPVQEDATQETHISSPVES 314
+ + ++ QI LL++Y L G S T+ ++P+Q +SS V+S
Sbjct: 1081 AMRVAAKNGHS---QIIKLLEKYGASSLNGCSPSPVHTMEQKPLQS-------LSSKVQS 1130
Query: 315 PSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQ 374
+ K+ S TG L ++F + S +S L + +
Sbjct: 1131 LTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNS 1190
Query: 375 SVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGF-PMLAQESYPKKRNY 433
S+RT+S S P + NL F + Q S P+ R+
Sbjct: 1191 SLRTTS---------------------STATAQTVPIDSFHNLSFTEQIQQHSLPRSRSR 1229
Query: 434 TMEIVPSAS 442
+ PS++
Sbjct: 1230 QSIVSPSST 1238
Score = 120 bits (301), Expect = 8e-27
Identities = 98/276 (35%), Positives = 128/276 (46%), Gaps = 21/276 (7%)
Query: 7 LLEAARTGNVALVEKLLS-----------GRKGGILGGGSGPLPLSNLLSIWRGPNVNCT 55
L AA +G++ +V L+S G L G + N L I G N+N T
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL-IGCGANINHT 607
Query: 56 DSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHG 115
D G+TAL AA GH ++V LL + AD + AAW G +IV L+ HG
Sbjct: 608 DQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG 667
Query: 116 PSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL----- 170
+ VN+ +NE TAL AA GH E+V LL+ + + T L +AAL
Sbjct: 668 ---AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPAS 724
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SA 229
G VV ++I + C+ TPL +AA GH VV +LLE G DV G +
Sbjct: 725 KGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTP 784
Query: 230 LHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
L AA G VV LL G + DS GRTVL I
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
Score = 90.1 bits (222), Expect = 1e-17
Identities = 71/221 (32%), Positives = 109/221 (49%), Gaps = 9/221 (4%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G +VN DS+G T L +AA +G D+V L+ A + D G+ P+ LAA +G ++V
Sbjct: 535 GASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
LI G + +N + + TAL AA GH+EVV+ LL ++ T L A
Sbjct: 595 NCLIGCG---ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
A G +V ++ + + T L AA GH+ +V+ LL+ G +V+ + G
Sbjct: 652 AWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGR 711
Query: 228 SALHEAALF-----GKVDVVRVLLETGIDANIKDSLGRTVL 263
+AL AAL G VV +L++ G + + D G T L
Sbjct: 712 TALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPL 752
Score = 79.0 bits (193), Expect = 3e-14
Identities = 62/193 (32%), Positives = 95/193 (49%), Gaps = 6/193 (3%)
Query: 72 KDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETA 131
++++ L++ A N D++ + A + D ++ L+ +G S VN+ ++ T
Sbjct: 494 QEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDS--IRTLLDNGAS---VNQCDSNGRTL 548
Query: 132 LHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCN 191
L AA G +VV +L+ D I ++ TPL LAA G +VV +I N+ +
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTD 608
Query: 192 TRKHTPLHLAARNGHKAVVQVLLEAGMDVSC-QTEKGSALHEAALFGKVDVVRVLLETGI 250
T L AA GH VV LL AG+ V C + +AL AA G D+V LL+ G
Sbjct: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668
Query: 251 DANIKDSLGRTVL 263
+ N D+ GRT L
Sbjct: 669 EVNKADNEGRTAL 681
Score = 36.2 bits (82), Expect = 0.20
Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 210 VQVLLEAGMDVS-CQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
++ LL+ G V+ C + + L AA G +DVV +L+ G D I+D+ G T L +
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTL 584
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 120 bits (300), Expect = 1e-26
Identities = 82/233 (35%), Positives = 126/233 (54%), Gaps = 7/233 (3%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
NVN +D +G TALHHAA +GH ++V LL A+ N D K IH AA+ G +E+VK+
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ HG + V ++ ++ T LH AA G VV LL+ D N+ TPL +A
Sbjct: 192 LVSHG---AEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACY 248
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAV-VQVLLEAGMDVSCQTEKGSA 229
G+ VV +I + N + TPLH AA + H A+ +++L+ G DV+ +++ G
Sbjct: 249 NGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKT 308
Query: 230 -LHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
LH AL G+ + ++++G + +D G T L I + + L I TL+
Sbjct: 309 PLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE--LLINTLI 359
Score = 111 bits (277), Expect = 5e-24
Identities = 79/252 (31%), Positives = 119/252 (47%), Gaps = 32/252 (12%)
Query: 44 LSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKG 103
L + RG N+N D A+H AA GH ++V L+ + A D K Y P+H AA G
Sbjct: 158 LLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSG 217
Query: 104 DVEIVKILIHHG------------PSH------------------SRVNEQNNENETALH 133
+ +VK L+ G P H + VN++N + T LH
Sbjct: 218 MISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLH 277
Query: 134 CAAQYGHSEV-VAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNT 192
AA H + + +L+ D +++ +TPL + AL+GR + II + + +
Sbjct: 278 FAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDK 337
Query: 193 RKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGS-ALHEAALFGKVDVVRVLLETGID 251
+TPLH+AAR GH+ ++ L+ +G D + + G LH AAL G D R LL +G D
Sbjct: 338 NGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFD 397
Query: 252 ANIKDSLGRTVL 263
+ D GRT L
Sbjct: 398 IDTPDDFGRTCL 409
Score = 109 bits (273), Expect = 1e-23
Identities = 75/222 (33%), Positives = 116/222 (52%), Gaps = 7/222 (3%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
+VN D + T LH AA N L+ ++ NV+D G +H AA+ G E+VK+
Sbjct: 99 DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKL 158
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ G + +N + ++ A+H AA GH EVV +L+ + T ++ K TPL AA
Sbjct: 159 LLSRG---ANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAAS 215
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SA 229
G + VVK ++ ++ N +TPLH+A NG VV L++ G V+ + EKG +
Sbjct: 216 SGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTP 275
Query: 230 LHEAA--LFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEH 269
LH AA G + + +L+ G D N+K G+T L + H
Sbjct: 276 LHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALH 316
Score = 106 bits (265), Expect = 1e-22
Identities = 77/222 (34%), Positives = 113/222 (50%), Gaps = 6/222 (2%)
Query: 44 LSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKG 103
L I G VN DS T LH A + ++ V LL++ A N D P+H+AA
Sbjct: 59 LLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANK 118
Query: 104 DVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLET 163
V+ + L+ P S VN + TALH AA GH E+V +LL + + K
Sbjct: 119 AVKCAEALV---PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR 175
Query: 164 PLDLAALYGRLRVVKMIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEAGMDVSC 222
+ AA G + VVK+++S H ++C +K +TPLH AA +G +VV+ LL+ G+D++
Sbjct: 176 AIHWAAYMGHIEVVKLLVS-HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNE 234
Query: 223 QTEKGSA-LHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
G+ LH A G+ VV L++ G N K+ G T L
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276
Score = 103 bits (256), Expect = 1e-21
Identities = 68/221 (30%), Positives = 114/221 (51%), Gaps = 4/221 (1%)
Query: 46 IWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDV 105
I++ +VN D+ T LH AA G +I+ L+ A N D+K P+H A
Sbjct: 28 IFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSE 87
Query: 106 EIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPL 165
E V++L+ H + VN ++ +T LH AA + L+ L++ + + T L
Sbjct: 88 EAVQVLLKHS---ADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTAL 144
Query: 166 DLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTE 225
AA G +VK+++S N+ + + + +H AA GH VV++L+ G +V+C+ +
Sbjct: 145 HHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDK 204
Query: 226 KG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
K + LH AA G + VV+ LL+ G+D N ++ G T L +
Sbjct: 205 KSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Score = 101 bits (251), Expect = 5e-21
Identities = 66/203 (32%), Positives = 106/203 (52%), Gaps = 4/203 (1%)
Query: 62 ALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRV 121
+L A NG D V L+ + N DN+ P+H AA+ GD EI+++LI G +RV
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSG---ARV 67
Query: 122 NEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMII 181
N ++++ T LH A E V VLL+ D R+ +TPL +AA ++ + ++
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Query: 182 SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVD 240
N+ + T LH AA +GH +V++LL G +++ +K A+H AA G ++
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
Query: 241 VVRVLLETGIDANIKDSLGRTVL 263
VV++L+ G + KD T L
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPL 210
Score = 100 bits (249), Expect = 9e-21
Identities = 74/230 (32%), Positives = 113/230 (49%), Gaps = 15/230 (6%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLK-LLQYEASTNVADNKGYFPIHLAAWKGDVEI 107
G +VN D G T LH+AA + L+ LL+ +A+ + D +GY +H +A G
Sbjct: 461 GASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLC 520
Query: 108 VKILIHHGP---------SHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRN 158
++++ P + + N + LH AA +GH + + VL++ L D +RN
Sbjct: 521 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 580
Query: 159 SKLETPLDLAALYGRLRVVKMIISAHPN-LMSCNTRKHTPLHLAARNGHKAVVQVLL--- 214
S TPLDLAA G + V ++I+ + L+ K TP+H AA NGH +++L+
Sbjct: 581 SSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNA 640
Query: 215 EAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
E V Q G + L + L G D V LL G + + KD GRT L
Sbjct: 641 EPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTAL 690
Score = 89.4 bits (220), Expect = 2e-17
Identities = 78/268 (29%), Positives = 119/268 (44%), Gaps = 45/268 (16%)
Query: 32 GGGSGPLPLSNLLS--------IWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEA 83
G G PL LS L + +G NV+ D G TALH A+ GH++ V LLQ+ A
Sbjct: 651 GNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710
Query: 84 STNVADNKGYFPIHLAAWKGDVEIVKILIHHGPS-HSRVNEQNNENETALHCAAQYGHSE 142
+ D++G PIHL+A G + ++ L+ S + +N TALH A GH
Sbjct: 711 KCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHET 770
Query: 143 VVAVLLEE----------------------------LTDP------TIRNSKLETPLDLA 168
V +LLE+ L D +SK TPL A
Sbjct: 771 CVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAA 830
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLL-EAGMDVSCQ-TEK 226
A + +++++S + + S ++ TPL +AA NG V++L+ A +++ Q K
Sbjct: 831 AFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 890
Query: 227 GSALHEAALFGKVDVVRVLLETGIDANI 254
+ALH A G ++LE D N+
Sbjct: 891 NTALHLACSKGHETSALLILEKITDRNL 918
Score = 87.4 bits (215), Expect = 8e-17
Identities = 55/170 (32%), Positives = 86/170 (50%), Gaps = 5/170 (2%)
Query: 52 VNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKIL 111
VN TDS G T LH AA H + + LL + A N D+ G P+ +AA G V++L
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Query: 112 IHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTI---RNSKLETPLDLA 168
+ + + + Q+N TALH A GH ++LE++TD + N+ L+TPL +A
Sbjct: 876 V--SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVA 933
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGM 218
A G VV+ ++ ++++ + +TP A N A L+ A M
Sbjct: 934 ARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATM 983
Score = 84.7 bits (208), Expect = 5e-16
Identities = 71/216 (32%), Positives = 100/216 (46%), Gaps = 7/216 (3%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
N D+ GYTALH A NGH+ V LL+ E N + P+H A + ++
Sbjct: 748 NPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN-AFSPLHCAVINDNEGAAEM 806
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
LI + S VN +++ T LH AA H E + +LL +S +TPL +AA
Sbjct: 807 LIDTLGA-SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAE 865
Query: 171 YGRLRVVKMIIS-AHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSA 229
G+ V+M++S A L + K+T LHLA GH+ ++LE D + +A
Sbjct: 866 NGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAA 925
Query: 230 ----LHEAALFGKVDVVRVLLETGIDANIKDSLGRT 261
LH AA G VV+ LL G D G T
Sbjct: 926 LQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961
Score = 80.1 bits (196), Expect = 1e-14
Identities = 66/259 (25%), Positives = 113/259 (43%), Gaps = 45/259 (17%)
Query: 61 TALHHAALNGHKDIVLKLL---QYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPS 117
T +H AA NGH + + L+ + + + ++ D G P+ L+ G + V L++ G
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKG-- 676
Query: 118 HSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVV 177
+ V+ ++ TALH A GH E V LL+ +R+S+ TP+ L+A G + V+
Sbjct: 677 -ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735
Query: 178 KMII----SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLE------------------ 215
++ S N + + +T LH A NGH+ V++LLE
Sbjct: 736 GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCA 795
Query: 216 ----------------AGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSL 258
V+ KG + LH AA V+ +++LL N DS
Sbjct: 796 VINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDST 855
Query: 259 GRTVLDILKEHPSQKSLQI 277
G+T L + E+ ++++
Sbjct: 856 GKTPLMMAAENGQTNTVEM 874
Score = 79.0 bits (193), Expect = 3e-14
Identities = 64/217 (29%), Positives = 100/217 (46%), Gaps = 5/217 (2%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYE-ASTNVADNKGYFPIHLAAWKGDVEI 107
G VN + G+T LH AA + H + L+LL A N+ G P+H+ A G
Sbjct: 262 GAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSR 321
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDL 167
+ +I G + ++ ++ T LH AA+YGH ++ L+ D R PL L
Sbjct: 322 SQTIIQSG---AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378
Query: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
AAL G + ++S+ ++ + + T LH AA G+ + +LL G D + + + G
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
Query: 228 -SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
S LH AA + L+ +G N D G T L
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPL 475
Score = 75.1 bits (183), Expect = 4e-13
Identities = 68/267 (25%), Positives = 114/267 (42%), Gaps = 50/267 (18%)
Query: 46 IWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDV 105
I G ++C D +G T LH AA GH+ ++ L+ A T G FP+HLAA G
Sbjct: 326 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385
Query: 106 EIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPL 165
+ + L+ G ++ ++ T LH AA G+ E + +LL D ++ +PL
Sbjct: 386 DCCRKLLSSG---FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPL 442
Query: 166 DLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARN--------------------- 204
AA + + ++ + ++ + R TPLH AA +
Sbjct: 443 HYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRD 502
Query: 205 -------------GHKAVVQVLL-EAGMDVSCQTEKG------------SALHEAALFGK 238
GH+ +Q++ E +DV +T S LH AA G
Sbjct: 503 KQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGH 562
Query: 239 VDVVRVLLETGIDANIKDSLGRTVLDI 265
+ VL+++ +D ++++S GRT LD+
Sbjct: 563 HQALEVLVQSLLDLDVRNSSGRTPLDL 589
Score = 74.7 bits (182), Expect = 5e-13
Identities = 62/203 (30%), Positives = 96/203 (47%), Gaps = 6/203 (2%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADN-KGYFPIHLAAWKGDVEIVK 109
+++ +SSG T L AA GH + V L+ AS V D PIH AA G E ++
Sbjct: 575 DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLR 634
Query: 110 ILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAA 169
+LI + + V+ Q+ +T L + GH++ V LL + + ++ T L A
Sbjct: 635 LLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGA 694
Query: 170 LYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLE--AGMDVSCQTEKG 227
+ G V ++ + ++R TP+HL+A GH V+ LL+ A MD + T
Sbjct: 695 VTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADN 754
Query: 228 ---SALHEAALFGKVDVVRVLLE 247
+ALH A G V +LLE
Sbjct: 755 HGYTALHWACYNGHETCVELLLE 777
Score = 43.5 bits (101), Expect = 0.001
Identities = 33/116 (28%), Positives = 56/116 (48%), Gaps = 4/116 (3%)
Query: 177 VKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAAL 235
V+ +I ++ + K TPLH AA G ++++L+ +G V+ + K + LH A
Sbjct: 24 VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVA 83
Query: 236 FGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRS 291
+ V+VLL+ D N +D +T L I + K+++ A L L V S
Sbjct: 84 SCSEEAVQVLLKHSADVNARDKNWQTPLHIA---AANKAVKCAEALVPLLSNVNVS 136
Score = 37.4 bits (85), Expect = 0.090
Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 1/86 (1%)
Query: 193 RKHTPLHLAARNGHKAVVQVLLEAGMDVSCQ-TEKGSALHEAALFGKVDVVRVLLETGID 251
R L A NG V+ L+ DV+ Q EK + LH AA G +++ +L+ +G
Sbjct: 7 RDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR 66
Query: 252 ANIKDSLGRTVLDILKEHPSQKSLQI 277
N KDS T L S++++Q+
Sbjct: 67 VNAKDSKWLTPLHRAVASCSEEAVQV 92
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 114 bits (286), Expect = 4e-25
Identities = 76/237 (32%), Positives = 117/237 (49%), Gaps = 5/237 (2%)
Query: 30 ILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVAD 89
++ G G + + LL I RG ++ D G A++ AA +GH D + L + + +V D
Sbjct: 384 LIAAGCGNIQILQLL-IKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD 442
Query: 90 NKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLE 149
G +H+AA G ++ ++L G S N Q+ E ET LHCAA +G+ V L E
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFG---SNPNIQDKEEETPLHCAAWHGYYSVAKALCE 499
Query: 150 ELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAV 209
+ I+N + ETPL A+ G +V+ + +L +C+ H LHLA R V
Sbjct: 500 AGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEV 559
Query: 210 VQVLLEAGMDVSCQTEKGSA-LHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
++ LL G V Q G+ LH A G + +V L E + +I + GRT L +
Sbjct: 560 IKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHL 616
Score = 94.4 bits (233), Expect = 6e-19
Identities = 69/227 (30%), Positives = 114/227 (50%), Gaps = 4/227 (1%)
Query: 40 LSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLA 99
L +LL +VN + G L AA G+ I+ L++ + +V D G ++ A
Sbjct: 360 LQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWA 419
Query: 100 AWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNS 159
A G V+ +K L + ++ ++ E ALH AA+YGH++V +L ++P I++
Sbjct: 420 ARHGHVDTLKFL---SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDK 476
Query: 160 KLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMD 219
+ ETPL AA +G V K + A N+ N TPL A+ G+ +V+ L E G D
Sbjct: 477 EEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGAD 536
Query: 220 V-SCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
+ +C + ALH A +++V++ LL G + +D G T L +
Sbjct: 537 LNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHV 583
Score = 87.0 bits (214), Expect = 1e-16
Identities = 80/274 (29%), Positives = 115/274 (41%), Gaps = 52/274 (18%)
Query: 7 LLEAARTGNVALVEKLLSGRKGGILG----GGS---------GPLPLSNLLSIWRGPNVN 53
LL AA GN+ +++ L+ ++G + GGS G + LS + P ++
Sbjct: 383 LLIAAGCGNIQILQLLI--KRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCP-LD 439
Query: 54 CTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIH 113
D SG ALH AA GH D+ L + ++ N+ D + P+H AAW G + K L
Sbjct: 440 VKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCE 499
Query: 114 HGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPT-------------IRNSK 160
G VN +N E ET L A+ G+ ++V L E D +R +
Sbjct: 500 AG---CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556
Query: 161 LE--------------------TPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHL 200
+E TPL +A G + +V + A+ NL N TPLHL
Sbjct: 557 MEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHL 616
Query: 201 AARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAA 234
AA NG VV+ L G V T G + A
Sbjct: 617 AANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
Score = 75.1 bits (183), Expect = 4e-13
Identities = 54/171 (31%), Positives = 79/171 (46%), Gaps = 3/171 (1%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G NVN + G T L A+ G+ DIV L ++ A N D G+ +HLA + +E++
Sbjct: 501 GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVI 560
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
K L+ G V+ Q+ T LH A + G+ +V L E + I N TPL LA
Sbjct: 561 KTLLSQG---CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMD 219
A G L VV+ + ++ + T T LA H+ V +L D
Sbjct: 618 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKD 668
Score = 45.8 bits (107), Expect = 3e-04
Identities = 39/118 (33%), Positives = 58/118 (49%), Gaps = 6/118 (5%)
Query: 40 LSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLA 99
+ LLS +G V+ D G T LH A +G+ IV+ L + + ++++ G P+HLA
Sbjct: 560 IKTLLS--QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617
Query: 100 AWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIR 157
A G +++V+ L G S V + +TA A H E VA LL L T R
Sbjct: 618 ANNGILDVVRYLCLMGAS---VEALTTDGKTAEDLARSEQH-EHVAGLLARLRKDTHR 671
Score = 44.7 bits (104), Expect = 6e-04
Identities = 30/107 (28%), Positives = 53/107 (49%), Gaps = 1/107 (0%)
Query: 164 PLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQ 223
PL +AA G +++++++I + + ++ AAR+GH ++ L E + +
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441
Query: 224 TEKGS-ALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEH 269
+ G ALH AA +G DV ++L G + NI+D T L H
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 114 bits (286), Expect = 4e-25
Identities = 80/242 (33%), Positives = 116/242 (47%), Gaps = 11/242 (4%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
+V+C +SGYT L AA + D+ LL + A N D G+ P+H AA GD ++
Sbjct: 387 DVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARL 446
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ HG V+ Q E T LH AAQ V +L+ DP + ++ +TPL +AA
Sbjct: 447 LLDHGAC---VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SA 229
+G + +VK++ S L + TPLHLA G +Q LL++G + G
Sbjct: 504 FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563
Query: 230 LHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI--LKEHPSQKSLQIATLLQEYLEG 287
LH AA GK + ++LL G + G T L + K H L+I LL E
Sbjct: 564 LHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGH-----LEIIHLLAESHAN 618
Query: 288 VG 289
+G
Sbjct: 619 MG 620
Score = 104 bits (259), Expect = 6e-22
Identities = 64/168 (38%), Positives = 90/168 (53%), Gaps = 3/168 (1%)
Query: 56 DSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHG 115
D SGY LH AA G I LL+Y AS + ++G+ P+HLAA+KG +EI+ +L
Sbjct: 557 DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAE-- 614
Query: 116 PSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLR 175
SH+ + N T LH AA++G VV+ LL+ DP TPL LA
Sbjct: 615 -SHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFL 673
Query: 176 VVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQ 223
V ++ H N+ + N TP HLAA G+ A+++VL+EAG + Q
Sbjct: 674 SVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
Score = 99.4 bits (246), Expect = 2e-20
Identities = 71/246 (28%), Positives = 118/246 (47%), Gaps = 6/246 (2%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G V+ + G+T LH AA N +++ L+ +A N+ + +G P+H+AA+ G V +V
Sbjct: 451 GACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
K+L G + ++ Q T LH A + G + LL+ P + PL A
Sbjct: 511 KLLTSQG---AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTA 567
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDV-SCQTEKG 227
A G+ + KM++ +L + TPLHLAA GH ++ +L E+ ++ +
Sbjct: 568 AARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNW 627
Query: 228 SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEG 287
+ LH AA G+ VV LL+ G D N + G T L + + + L + LL+ +
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST--FLSVINLLEHHANV 685
Query: 288 VGRSTV 293
R+ V
Sbjct: 686 HARNKV 691
Score = 97.8 bits (242), Expect = 6e-20
Identities = 64/240 (26%), Positives = 114/240 (47%), Gaps = 6/240 (2%)
Query: 44 LSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKG 103
L + G + N D G+ LH AA NG LL + A + + +G+ P+HLAA
Sbjct: 413 LLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNN 472
Query: 104 DVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLET 163
+ ++L+ + N E +T LH AA +GH +V +L + + + L T
Sbjct: 473 FENVARLLVSR---QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRT 529
Query: 164 PLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQ 223
PL LA G++R ++ ++ + + + + PLH AA G + ++LL G +
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589
Query: 224 TEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQ 282
T +G + LH AA G ++++ +L E+ + ++ T L + H + ++ LLQ
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEE--AVVSALLQ 647
Score = 63.2 bits (152), Expect = 2e-09
Identities = 40/145 (27%), Positives = 70/145 (48%), Gaps = 5/145 (3%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGD-VEIVK 109
N+ + +T LH AA +G + +V LLQ A N A+ G+ P+HLA + + ++
Sbjct: 618 NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677
Query: 110 ILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAA 169
+L HH H+R N T H AA G++ ++ VL+E +++ TPL LA
Sbjct: 678 LLEHHANVHAR----NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL 733
Query: 170 LYGRLRVVKMIISAHPNLMSCNTRK 194
+ ++ + P++ + K
Sbjct: 734 RSRKQGIMSFLEGKEPSVATLGGSK 758
Score = 49.3 bits (116), Expect = 2e-05
Identities = 29/99 (29%), Positives = 53/99 (53%), Gaps = 3/99 (3%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G + N + SG+T LH A V+ LL++ A+ + + G+ P HLAA KG+ I+
Sbjct: 649 GADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAIL 708
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVL 147
K+L+ G ++++ Q+ + T L A + +++ L
Sbjct: 709 KVLVEAG---AQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 113 bits (283), Expect = 1e-24
Identities = 78/229 (34%), Positives = 115/229 (50%), Gaps = 7/229 (3%)
Query: 44 LSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKG 103
L + R +VN D +TALH AA NG + LL+ AS N D +G P+H+A G
Sbjct: 489 LLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548
Query: 104 DVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLE- 162
IV+IL+ G V+ Q + LH AA GH +V +L ++ ++ L+
Sbjct: 549 QENIVRILLRRGVD---VSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ-PGVSVNAQTLDG 604
Query: 163 -TPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVS 221
TPL LAA G RV +++I ++ C+ TPLH+AA GH + ++LL G
Sbjct: 605 RTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKE 664
Query: 222 CQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEH 269
T G +ALH AA G + V++L+E D + L +T L + H
Sbjct: 665 AMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAH 713
Score = 110 bits (276), Expect = 6e-24
Identities = 77/243 (31%), Positives = 125/243 (51%), Gaps = 6/243 (2%)
Query: 41 SNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAA 100
S L + + +VN D G T +H A +G ++IV LL+ ++ + P+H AA
Sbjct: 519 STRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAA 578
Query: 101 WKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSK 160
W+G + IVK+L P S VN Q + T LH AAQ GH V +L++ +D + +
Sbjct: 579 WQGHLPIVKLLAKQ-PGVS-VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLL 636
Query: 161 LETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDV 220
+TPL +AA G ++++ + + +T LHLAARNGH A V++L+E DV
Sbjct: 637 AQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADV 696
Query: 221 SCQTE-KGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIAT 279
+ +ALH AA G +VV L+ + ++ D G + L + + + + + T
Sbjct: 697 LARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQ--GRHAQTVET 753
Query: 280 LLQ 282
LL+
Sbjct: 754 LLR 756
Score = 100 bits (249), Expect = 9e-21
Identities = 69/217 (31%), Positives = 101/217 (46%), Gaps = 5/217 (2%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
N N ++ G T LH A + +V LL + S N D + +H AA GD ++
Sbjct: 463 NPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRL 522
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ S VNE + E T +H A Q+G +V +LL D +++ PL AA
Sbjct: 523 LLEKNAS---VNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAW 579
Query: 171 YGRLRVVKMIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEAGMDVS-CQTEKGS 228
G L +VK++ ++ T TPLHLAA+ GH V ++L++ DV+ C +
Sbjct: 580 QGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQT 639
Query: 229 ALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
LH AA G R+LL G S G T L +
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHL 676
Score = 94.7 bits (234), Expect = 5e-19
Identities = 65/199 (32%), Positives = 96/199 (48%), Gaps = 4/199 (2%)
Query: 36 GPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFP 95
G LP+ LL+ G +VN G T LH AA GH + L+ + NV P
Sbjct: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTP 640
Query: 96 IHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPT 155
+H+AA G ++L+H G + ++ TALH AA+ GH V +L+EE D
Sbjct: 641 LHVAAETGHTSTARLLLHRGAGKEAM---TSDGYTALHLAARNGHLATVKLLVEEKADVL 697
Query: 156 IRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLE 215
R +T L LAA +G VV+ ++SA + + + + LHLAA+ H V+ LL
Sbjct: 698 ARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR 756
Query: 216 AGMDVSCQTEKGSALHEAA 234
G ++ Q+ K H A
Sbjct: 757 HGAHINLQSLKFQGGHGPA 775
Score = 91.3 bits (225), Expect = 5e-18
Identities = 67/230 (29%), Positives = 117/230 (50%), Gaps = 5/230 (2%)
Query: 41 SNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAA 100
S L+ I + +V+ SG + LH A G ++ LL A+ N+++ +G P+H+A
Sbjct: 420 SKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479
Query: 101 WKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSK 160
+ +V++L+ S VN ++ + TALH AAQ G +LLE+ + +
Sbjct: 480 ERRVRGVVELLLARKIS---VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFE 536
Query: 161 LETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLL-EAGMD 219
TP+ +A +G+ +V++++ ++ PLH AA GH +V++L + G+
Sbjct: 537 GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
Query: 220 VSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKE 268
V+ QT G + LH AA G V R+L++ D N+ L +T L + E
Sbjct: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAE 646
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 113 bits (282), Expect = 1e-24
Identities = 79/261 (30%), Positives = 120/261 (45%), Gaps = 33/261 (12%)
Query: 35 SGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYF 94
+G + + NLL + +G N+N D ALH AA GH D+V L+ + A D KGY
Sbjct: 125 NGHVEMVNLL-LAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYT 183
Query: 95 PIHLAAWKGDVEIVKILIHHGPS------------------------------HSRVNEQ 124
P+H AA G + +VK L++ G + VN+
Sbjct: 184 PLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQP 243
Query: 125 NNENETALHCAAQYGHSEV-VAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISA 183
NN T LH AA H + + +L+ D I++ ++PL + A++GR + +I
Sbjct: 244 NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN 303
Query: 184 HPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVS-CQTEKGSALHEAALFGKVDVV 242
+ + +TPLH+AAR GH+ ++ L +G D + C LH AAL D
Sbjct: 304 GGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCC 363
Query: 243 RVLLETGIDANIKDSLGRTVL 263
R LL +G + + D GRT L
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCL 384
Score = 105 bits (261), Expect = 4e-22
Identities = 73/222 (32%), Positives = 115/222 (51%), Gaps = 7/222 (3%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
+VN D + T LH AA N ++ +S NV+D G +H AA G VE+V +
Sbjct: 74 DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNL 133
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ G + +N + ++ ALH AA GH +VVA+L+ + T ++ K TPL AA
Sbjct: 134 LLAKG---ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAAS 190
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SA 229
G++ VVK +++ + N +T LH+A NG AVV L++ G +V+ G +
Sbjct: 191 NGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTP 250
Query: 230 LHEAA--LFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEH 269
LH AA G + + +L+ G D NI+ G++ L + H
Sbjct: 251 LHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVH 291
Score = 102 bits (255), Expect = 2e-21
Identities = 70/221 (31%), Positives = 113/221 (51%), Gaps = 4/221 (1%)
Query: 46 IWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDV 105
I + +VN DS T LH AA G +I+ L+ A N DN P+H A
Sbjct: 3 IHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSE 62
Query: 106 EIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPL 165
E V++LI H + VN ++ +T LH AA + V++ L+ + + T L
Sbjct: 63 EAVQVLIKHS---ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
Query: 166 DLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTE 225
AAL G + +V ++++ N+ + + + LH AA GH VV +L+ G +V+C+ +
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Query: 226 KG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
KG + LH AA G+++VV+ LL G++ + + G T L I
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 220
Score = 102 bits (253), Expect = 3e-21
Identities = 64/207 (30%), Positives = 106/207 (51%), Gaps = 5/207 (2%)
Query: 59 GYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEI-VKILIHHGPS 117
G TALH A NG +V +L+ Y A+ N +N G+ P+H AA + +++L+++G
Sbjct: 214 GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD 273
Query: 118 HSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVV 177
VN Q+ + ++ LH A +G L++ + + TPL +AA YG ++
Sbjct: 274 ---VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLI 330
Query: 178 KMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALF 236
+ ++ + C PLHLAA N H + LL +G ++ + G + LH AA
Sbjct: 331 NTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAG 390
Query: 237 GKVDVVRVLLETGIDANIKDSLGRTVL 263
G V+ +++L +G D + KD GRT L
Sbjct: 391 GNVECIKLLQSSGADFHKKDKCGRTPL 417
Score = 102 bits (253), Expect = 3e-21
Identities = 82/248 (33%), Positives = 121/248 (48%), Gaps = 34/248 (13%)
Query: 49 GPNVNCTDSSGYTALHHAAL-----------NGH--------------KDIVLKL---LQ 80
G NVN TD G TALH+AA N H K+ L L LQ
Sbjct: 436 GANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQ 495
Query: 81 YEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGH 140
+A+ ++ D +GY IH AA G + +++L+ S ++ + ++ LH AA GH
Sbjct: 496 NDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESD-SGATKSPLHLAAYNGH 554
Query: 141 SEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNL-MSCNTRKHTPLH 199
+ + VLL+ L D IR+ K T LDLAA G V+ +I+ ++ + N K TPLH
Sbjct: 555 HQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLH 614
Query: 200 LAARNGHKAVVQVLLEAGMD---VSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIK 255
+ NGH +++LLE + V + KG + L A +G +D V +LLE + +
Sbjct: 615 ASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTV 674
Query: 256 DSLGRTVL 263
D LG T L
Sbjct: 675 DILGCTAL 682
Score = 99.8 bits (247), Expect = 1e-20
Identities = 75/222 (33%), Positives = 112/222 (50%), Gaps = 6/222 (2%)
Query: 44 LSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKG 103
L I G VN D+ T LH A + ++ V L+++ A N D P+H+AA
Sbjct: 34 LLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANK 93
Query: 104 DVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLET 163
V+ +++I P S VN + TALH AA GH E+V +LL + + + K
Sbjct: 94 AVKCAEVII---PLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRR 150
Query: 164 PLDLAALYGRLRVVKMIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEAGMDV-S 221
L AA G L VV ++I+ H ++C +K +TPLH AA NG VV+ LL G+++
Sbjct: 151 ALHWAAYMGHLDVVALLIN-HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDE 209
Query: 222 CQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
+ALH A G+ VV L++ G + N ++ G T L
Sbjct: 210 INVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPL 251
Score = 98.6 bits (244), Expect = 3e-20
Identities = 69/208 (33%), Positives = 105/208 (50%), Gaps = 9/208 (4%)
Query: 63 LHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVN 122
LH AA NGH + LLQ ++ D KG + LAA+KG E V+ LI+ P S
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALIN--PGASIFV 603
Query: 123 EQNNENETALHCAAQYGHSEVVAVLLEELTDPT---IRNSKLETPLDLAALYGRLRVVKM 179
+ N T LH + GH+ + +LLE +P ++++K +TPL LA YG + V +
Sbjct: 604 KDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSL 663
Query: 180 IISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGK 238
++ N+ + + T LH GH+ VQ+LLE + + C+ +G + LH AA G
Sbjct: 664 LLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723
Query: 239 VDVVRVLLETGI---DANIKDSLGRTVL 263
+ LL+ + D KD+ G T L
Sbjct: 724 ATWLSELLQMALSEEDCCFKDNQGYTPL 751
Score = 97.4 bits (241), Expect = 7e-20
Identities = 64/187 (34%), Positives = 98/187 (52%), Gaps = 4/187 (2%)
Query: 78 LLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQ 137
L+ N D++ P+H+AA+ GD EI+++LI G +RVN ++N T LH A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSG---ARVNAKDNMWLTPLHRAVA 58
Query: 138 YGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTP 197
E V VL++ D R+ +TPL +AA ++ ++II ++ + T
Sbjct: 59 SRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118
Query: 198 LHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKD 256
LH AA NGH +V +LL G +++ +K ALH AA G +DVV +L+ G + KD
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
Query: 257 SLGRTVL 263
G T L
Sbjct: 179 KKGYTPL 185
Score = 79.3 bits (194), Expect = 2e-14
Identities = 63/210 (30%), Positives = 97/210 (46%), Gaps = 5/210 (2%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
NV+ D G TALH + GH++ V LL+ E S D++G P+H AA +G +
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ S ++N+ T LH A G+ + VLLE+ + TPL A +
Sbjct: 730 LLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-TPLHCAII 788
Query: 171 YGRLRVVKMIISA-HPNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG- 227
+++ A +++SC K TPL AA H +Q+LL V+ G
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848
Query: 228 SALHEAALFGKVDVVRVLLETG-IDANIKD 256
+AL AA G+ V +L+ + D +KD
Sbjct: 849 TALMMAAENGQAGAVDILVNSAQADLTVKD 878
Score = 77.0 bits (188), Expect = 1e-13
Identities = 68/255 (26%), Positives = 112/255 (43%), Gaps = 17/255 (6%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPN------------VNCTDS 57
AA G+ +E LL G SG L+ + G + ++ D
Sbjct: 514 AAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDE 573
Query: 58 SGYTALHHAALNGHKDIVLKLLQYEASTNVADN-KGYFPIHLAAWKGDVEIVKILIHHGP 116
G TAL AA GH + V L+ AS V DN P+H + G +++L+
Sbjct: 574 KGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIAD 633
Query: 117 SHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRV 176
+ V+ ++ + +T L A YGH + V++LLE+ + + T L + G
Sbjct: 634 NPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEEC 693
Query: 177 VKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGM---DVSCQTEKG-SALHE 232
V+M++ +++ ++R TPLH AA GH + LL+ + D + +G + LH
Sbjct: 694 VQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHW 753
Query: 233 AALFGKVDVVRVLLE 247
A G + + VLLE
Sbjct: 754 ACYNGNENCIEVLLE 768
Score = 74.3 bits (181), Expect = 7e-13
Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 35/215 (16%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTN---VADNKGYFPIHLAAWKGDVEI 107
++ C DS G T LH+AA GH + +LLQ S DN+GY P+H A + G+
Sbjct: 703 SILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENC 762
Query: 108 VKILIHHG-----------PSH--------------------SRVNEQNNENETALHCAA 136
+++L+ P H S V+ ++++ T L AA
Sbjct: 763 IEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAA 822
Query: 137 QYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMII-SAHPNLMSCNTRKH 195
H E + +LL ++ +T L +AA G+ V +++ SA +L + +
Sbjct: 823 FADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN 882
Query: 196 TPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSAL 230
TPLHLA GH+ ++L+ D S EK +AL
Sbjct: 883 TPLHLACSKGHEKCALLILDKIQDESLINEKNNAL 917
Score = 72.0 bits (175), Expect = 3e-12
Identities = 61/220 (27%), Positives = 99/220 (45%), Gaps = 11/220 (5%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G ++ D G T LH AA G+ + + L A + D G P+H AA +
Sbjct: 370 GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCI 429
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+ L+ G + VNE ++ TALH AA +L + + +LE +L
Sbjct: 430 ETLVTTG---ANVNETDDWGRTALHYAAASDMDRNKTIL----GNAHDNSEELERARELK 482
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLE---AGMDVSCQTE 225
L ++ ++ N + + +H AA GH+ +++LLE +G + S
Sbjct: 483 EKEATL-CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
Query: 226 KGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
S LH AA G + VLL++ +D +I+D GRT LD+
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDL 581
Score = 60.8 bits (146), Expect = 8e-09
Identities = 56/231 (24%), Positives = 93/231 (40%), Gaps = 32/231 (13%)
Query: 46 IWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDV 105
I G ++C D G T LH AA GH+ ++ L A T FP+HLAA
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
Query: 106 EIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPL 165
+ + L+ G ++ + T LH AA G+ E + +L D ++ TPL
Sbjct: 361 DCCRKLLSSG---FEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPL 417
Query: 166 DLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAAR-----------NGH-------- 206
AA ++ +++ N+ + T LH AA N H
Sbjct: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELER 477
Query: 207 ---------KAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLE 247
++ LL+ + S + ++G +++H AA +G + +LLE
Sbjct: 478 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528
Score = 50.8 bits (120), Expect = 8e-06
Identities = 33/119 (27%), Positives = 59/119 (49%), Gaps = 1/119 (0%)
Query: 146 VLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNG 205
+L+ + D +S+ TPL +AA G +++++I + + + + TPLH A +
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 206 HKAVVQVLLEAGMDVSCQTEK-GSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
+ VQVL++ DV+ + + + LH AA V V++ N+ D GRT L
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
Score = 43.5 bits (101), Expect = 0.001
Identities = 25/100 (25%), Positives = 52/100 (52%), Gaps = 1/100 (1%)
Query: 179 MIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFG 237
M+I ++ + ++ K TPLH+AA G ++++L+ +G V+ + + LH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 238 KVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQI 277
+ V+VL++ D N +D +T L + + + K ++
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEV 100
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/80 (36%), Positives = 40/80 (50%), Gaps = 1/80 (1%)
Query: 52 VNCTDSSGYTALHHAALNGHKDIVLKLLQY-EASTNVADNKGYFPIHLAAWKGDVEIVKI 110
VN D+SG TAL AA NG V L+ +A V D P+HLA KG + +
Sbjct: 840 VNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALL 899
Query: 111 LIHHGPSHSRVNEQNNENET 130
++ S +NE+NN +T
Sbjct: 900 ILDKIQDESLINEKNNALQT 919
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 112 bits (281), Expect = 2e-24
Identities = 78/232 (33%), Positives = 121/232 (52%), Gaps = 7/232 (3%)
Query: 36 GPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNV-ADNKGYF 94
G + + ++L+ + N+ D+ T LH AAL GH IV LL+ S + +D++G
Sbjct: 232 GNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGAT 291
Query: 95 PIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP 154
P+H AA E VK+ + H S ++ + E T+ AA G +V+ +L +D
Sbjct: 292 PLHYAAQSNFAETVKVFLKH---PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
Query: 155 TIRNSKL--ETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQV 212
I + T L AAL G + VK+++ + + + + KHTPL A GHK V+Q
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
Query: 213 LLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
L++ G V + G S LH AAL G DV ++L+E I+ N++D GRT L
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 460
Score = 90.1 bits (222), Expect = 1e-17
Identities = 78/301 (25%), Positives = 141/301 (46%), Gaps = 13/301 (4%)
Query: 23 LSGRKGGILGGGSGPLP-LSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQY 81
L GR + G G L +LS+ ++N D G TALH AAL+GH V LL+
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379
Query: 82 EASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHS 141
A + D + P+ A G ++++ LI G +RV+ + + + LH AA G++
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG---ARVDLVDQDGHSLLHWAALGGNA 436
Query: 142 EVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMII--SAHPNLMSCNTRKHTPLH 199
+V +L+E +P +++ TPL AA G + + +++ +A PN+ R T LH
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR--TALH 494
Query: 200 LAARNGHKAVVQVLLEAGM---DVSCQTEKGSALHEAALFGKVDVVRVLLETGI--DANI 254
+ NG+ +++LL+ + E+ + L A L + +V++ +LE G A I
Sbjct: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAI 554
Query: 255 KDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQETHISSPVES 314
+D + + K + +K+ + L E + + ++ +E+ +E S
Sbjct: 555 QDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGRRS 614
Query: 315 P 315
P
Sbjct: 615 P 615
Score = 87.8 bits (216), Expect = 6e-17
Identities = 79/275 (28%), Positives = 132/275 (48%), Gaps = 23/275 (8%)
Query: 37 PLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPI 96
P L+ LL V+ D + TALH +A + + V L++++++ + D +G P+
Sbjct: 127 PKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPL 186
Query: 97 HLAAWKGD---VEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLE-ELT 152
H AA D V V+ ++ P+ S +N Q+ E T LH A G+ VV VL E
Sbjct: 187 HWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC 246
Query: 153 DPTIRNSKLETPLDLAALYGRLRVVKMIISAHPN-LMSCNTRKHTPLHLAARNGHKAVVQ 211
+ T ++ TPL AAL G ++V +++ + + + +++ TPLH AA++ V+
Sbjct: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306
Query: 212 VLLE-AGMDVSCQTEKGSALHEAALFGKVDVVRVL--LETGIDANIKDSLGRTVLDILKE 268
V L+ + E ++ AA G DV+R + L++ ID N+ D G T L
Sbjct: 307 VFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTAL----- 361
Query: 269 HPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDAT 303
H + S ++T+ +LE Q DAT
Sbjct: 362 HAAALSGHVSTV----------KLLLENNAQVDAT 386
Score = 76.6 bits (187), Expect = 1e-13
Identities = 70/224 (31%), Positives = 106/224 (47%), Gaps = 10/224 (4%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G +VN TD S TALH AA G+ + LL A+ D + P+HL + +
Sbjct: 71 GADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCL 130
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+L+ + V+ Q+ +TALH +A Y + E V +L++ ++ I + + + PL A
Sbjct: 131 ALLLKF-MAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA 189
Query: 169 ALY---GRLRVVKMIISAHPNLMSCNTRKH---TPLHLAARNGHKAVVQVL--LEAGMDV 220
A + + V+ I+ A P N + + TPLH A +G+ VV VL E+
Sbjct: 190 ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNIT 249
Query: 221 SCQTEKGSALHEAALFGKVDVVRVLLETGIDANI-KDSLGRTVL 263
S + LH AAL G +V +LLE I DS G T L
Sbjct: 250 SYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPL 293
Score = 50.1 bits (118), Expect = 1e-05
Identities = 47/177 (26%), Positives = 79/177 (44%), Gaps = 5/177 (2%)
Query: 96 IHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPT 155
+H AA GD ++ LI G S + E ++C + LL+ D
Sbjct: 18 VHAAAVNGDKGALQRLIV-GNSALKDKEDQFGRTPLMYCVLA-DRLDCADALLKAGADVN 75
Query: 156 IRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLE 215
+ T L LAA G R +K++++ N M + + TPLHL R+ + +LL+
Sbjct: 76 KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
Query: 216 --AGMDVSCQTE-KGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEH 269
A +V Q + K +ALH +A + + V++L++ + I D G+ L H
Sbjct: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Score = 32.3 bits (72), Expect = 2.9
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 2/94 (2%)
Query: 186 NLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEK--GSALHEAALFGKVDVVR 243
NL+ + + +H AA NG K +Q L+ + + ++ + L L ++D
Sbjct: 6 NLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCAD 65
Query: 244 VLLETGIDANIKDSLGRTVLDILKEHPSQKSLQI 277
LL+ G D N D RT L + + + + +++
Sbjct: 66 ALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKL 99
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 112 bits (281), Expect = 2e-24
Identities = 78/232 (33%), Positives = 121/232 (52%), Gaps = 7/232 (3%)
Query: 36 GPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNV-ADNKGYF 94
G + + ++L+ + N+ D+ T LH AAL GH IV LL+ S + +D++G
Sbjct: 232 GNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGAT 291
Query: 95 PIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP 154
P+H AA E VK+ + H S ++ + E T+ AA G +V+ +L +D
Sbjct: 292 PLHYAAQSNFAETVKVFLKH---PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
Query: 155 TIRNSKL--ETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQV 212
I + T L AAL G + VK+++ + + + + KHTPL A GHK V+Q
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
Query: 213 LLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
L++ G V + G S LH AAL G DV ++L+E I+ N++D GRT L
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 460
Score = 90.1 bits (222), Expect = 1e-17
Identities = 78/301 (25%), Positives = 141/301 (46%), Gaps = 13/301 (4%)
Query: 23 LSGRKGGILGGGSGPLP-LSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQY 81
L GR + G G L +LS+ ++N D G TALH AAL+GH V LL+
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379
Query: 82 EASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHS 141
A + D + P+ A G ++++ LI G +RV+ + + + LH AA G++
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG---ARVDLVDQDGHSLLHWAALGGNA 436
Query: 142 EVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMII--SAHPNLMSCNTRKHTPLH 199
+V +L+E +P +++ TPL AA G + + +++ +A PN+ R T LH
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR--TALH 494
Query: 200 LAARNGHKAVVQVLLEAGM---DVSCQTEKGSALHEAALFGKVDVVRVLLETGI--DANI 254
+ NG+ +++LL+ + E+ + L A L + +V++ +LE G A I
Sbjct: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAI 554
Query: 255 KDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQETHISSPVES 314
+D + + K + +K+ + L E + + ++ +E+ +E S
Sbjct: 555 QDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGRRS 614
Query: 315 P 315
P
Sbjct: 615 P 615
Score = 87.8 bits (216), Expect = 6e-17
Identities = 79/275 (28%), Positives = 132/275 (48%), Gaps = 23/275 (8%)
Query: 37 PLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPI 96
P L+ LL V+ D + TALH +A + + V L++++++ + D +G P+
Sbjct: 127 PKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPL 186
Query: 97 HLAAWKGD---VEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLE-ELT 152
H AA D V V+ ++ P+ S +N Q+ E T LH A G+ VV VL E
Sbjct: 187 HWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC 246
Query: 153 DPTIRNSKLETPLDLAALYGRLRVVKMIISAHPN-LMSCNTRKHTPLHLAARNGHKAVVQ 211
+ T ++ TPL AAL G ++V +++ + + + +++ TPLH AA++ V+
Sbjct: 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVK 306
Query: 212 VLLE-AGMDVSCQTEKGSALHEAALFGKVDVVRVL--LETGIDANIKDSLGRTVLDILKE 268
V L+ + E ++ AA G DV+R + L++ ID N+ D G T L
Sbjct: 307 VFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTAL----- 361
Query: 269 HPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDAT 303
H + S ++T+ +LE Q DAT
Sbjct: 362 HAAALSGHVSTV----------KLLLENNAQVDAT 386
Score = 76.6 bits (187), Expect = 1e-13
Identities = 70/224 (31%), Positives = 106/224 (47%), Gaps = 10/224 (4%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G +VN TD S TALH AA G+ + LL A+ D + P+HL + +
Sbjct: 71 GADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCL 130
Query: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
+L+ + V+ Q+ +TALH +A Y + E V +L++ ++ I + + + PL A
Sbjct: 131 ALLLKF-MAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA 189
Query: 169 ALY---GRLRVVKMIISAHPNLMSCNTRKH---TPLHLAARNGHKAVVQVL--LEAGMDV 220
A + + V+ I+ A P N + + TPLH A +G+ VV VL E+
Sbjct: 190 ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNIT 249
Query: 221 SCQTEKGSALHEAALFGKVDVVRVLLETGIDANI-KDSLGRTVL 263
S + LH AAL G +V +LLE I DS G T L
Sbjct: 250 SYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPL 293
Score = 50.1 bits (118), Expect = 1e-05
Identities = 47/177 (26%), Positives = 79/177 (44%), Gaps = 5/177 (2%)
Query: 96 IHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPT 155
+H AA GD ++ LI G S + E ++C + LL+ D
Sbjct: 18 VHAAAVNGDKGALQRLIV-GNSALKDKEDQFGRTPLMYCVLA-DRLDCADALLKAGADVN 75
Query: 156 IRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLE 215
+ T L LAA G R +K++++ N M + + TPLHL R+ + +LL+
Sbjct: 76 KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
Query: 216 --AGMDVSCQTE-KGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEH 269
A +V Q + K +ALH +A + + V++L++ + I D G+ L H
Sbjct: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Score = 32.3 bits (72), Expect = 2.9
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 2/94 (2%)
Query: 186 NLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEK--GSALHEAALFGKVDVVR 243
NL+ + + +H AA NG K +Q L+ + + ++ + L L ++D
Sbjct: 6 NLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCAD 65
Query: 244 VLLETGIDANIKDSLGRTVLDILKEHPSQKSLQI 277
LL+ G D N D RT L + + + + +++
Sbjct: 66 ALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKL 99
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 111 bits (278), Expect = 4e-24
Identities = 77/233 (33%), Positives = 128/233 (54%), Gaps = 7/233 (3%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
++N D SG +ALHHA +GH + V LL AS NV D K P+H AA+ G +E++K+
Sbjct: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ G + + ++ + LH AA G EVV LL + N+ T L +A
Sbjct: 192 LVARG---ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACY 248
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAV-VQVLLEAGMDVSCQTEKG-S 228
G+ V +++A N+ N + TPLH+AA + + A+ +++L+ G DV+ Q+++G S
Sbjct: 249 LGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKS 308
Query: 229 ALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLL 281
LH AA+ G+ ++L++ G + + D G T L + + + L I+TL+
Sbjct: 309 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHE--LLISTLM 359
Score = 98.2 bits (243), Expect = 4e-20
Identities = 65/216 (30%), Positives = 107/216 (49%), Gaps = 4/216 (1%)
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
N+N D T LH AA G I+ LL A+ N D P+H AA + +++ +
Sbjct: 33 NINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGL 92
Query: 111 LIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAAL 170
L+ H + VN ++ +T LH AA ++ L L+ + + + L A
Sbjct: 93 LLAHS---ADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVH 149
Query: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SA 229
G L V ++++ +L C+ ++ PLH AA GH V+++L+ G D+ C+ KG
Sbjct: 150 SGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGL 209
Query: 230 LHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
LH AA G+++VV+ LL G + + ++ G T L I
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
Score = 96.3 bits (238), Expect = 2e-19
Identities = 70/240 (29%), Positives = 117/240 (48%), Gaps = 23/240 (9%)
Query: 44 LSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKG 103
L + RG ++ C D GY LH AA +G ++V LL+ A + + G +H+A + G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
Query: 104 DVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEV-VAVLLEELTDPTIRNSKLE 162
+ L++ G + VN+ N++ T LH AA + + + +L+ D ++ + +
Sbjct: 251 QDAVAIELVNAG---ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK 307
Query: 163 TPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSC 222
+PL +AA++GR +++I + + +TPLH+AAR GH+ ++ L+ G D +
Sbjct: 308 SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTAR 367
Query: 223 Q-TEKGSALHEAALFGKVDVVRVLLET------------------GIDANIKDSLGRTVL 263
+ LH A LFG D R LL + G D N D+LGRT L
Sbjct: 368 RGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCL 427
Score = 95.5 bits (236), Expect = 3e-19
Identities = 73/232 (31%), Positives = 111/232 (47%), Gaps = 7/232 (3%)
Query: 36 GPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFP 95
G +P+ LL + G NVN D+ T LH AA + ++ ++ LL + A N D P
Sbjct: 52 GDVPILQLL-LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTP 110
Query: 96 IHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPT 155
+H+AA + + L P S +N + +ALH A GH E V +LL +
Sbjct: 111 LHVAAANRATKCAEAL---APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLN 167
Query: 156 IRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLL 214
+ + K PL AA G L V+K++++ +L C RK + LH AA +G VV+ LL
Sbjct: 168 VCDKKERQPLHWAAFLGHLEVLKLLVARGADL-GCKDRKGYGLLHTAAASGQIEVVKYLL 226
Query: 215 EAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
G ++ G +ALH A G+ V L+ G + N + G T L +
Sbjct: 227 RMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHV 278
Score = 75.9 bits (185), Expect = 2e-13
Identities = 75/313 (23%), Positives = 120/313 (38%), Gaps = 79/313 (25%)
Query: 46 IWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDV 105
I G ++C D G T LH AA GH+ ++ L+ A T FP+HLA G
Sbjct: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFS 385
Query: 106 EIVKILIHHGPSHSRVNEQNNEN---------------ETALHCAAQYGHSEVVAVLLEE 150
+ + L+ G +S V+ +NE+ T LH AA G+ E + +LL
Sbjct: 386 DCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 445
Query: 151 LTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAAR------- 203
D R+ TPL AA G + +++A + + + +PLH AA
Sbjct: 446 GADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRA 505
Query: 204 -----NGHKA----------------VVQVLLEAGMDVSCQTEKG--------------- 227
+ H A ++ LL+ G D S + +G
Sbjct: 506 EPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQN 565
Query: 228 ---------------------SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDIL 266
S LH AA G + ++ L ET ++ +++D GRT L +
Sbjct: 566 LELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLA 625
Query: 267 KEHPSQKSLQIAT 279
E S + +++ T
Sbjct: 626 TERGSTECVEVLT 638
Score = 75.9 bits (185), Expect = 2e-13
Identities = 71/252 (28%), Positives = 108/252 (42%), Gaps = 43/252 (17%)
Query: 56 DSSGYTALHHAALNGHKDIVLKLLQYEAST------------------------------ 85
D SGY+ +H A+ GH+D + LL++ +
Sbjct: 788 DYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALG 847
Query: 86 ----NVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHS 141
N D KG P+H AA+ +V +++L+ H + VN ++ TAL AA+ G +
Sbjct: 848 AKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH---QAEVNATDHTGRTALMTAAENGQT 904
Query: 142 EVVAVLLEE-LTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNL---MSCNTRKHTP 197
V LL D T+ + T L LA G + MI++ +L + N+ P
Sbjct: 905 AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMP 964
Query: 198 LHLAARNGHKAVVQVLLEAGMDVSCQTEKG--SALHEAALFGKVDVVRVLLETGIDANIK 255
LH+AARNG +VVQ LL G V E+G AL A D + ++L T K
Sbjct: 965 LHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPK 1024
Query: 256 DSLGRTVLDILK 267
D++ +LK
Sbjct: 1025 DAVSPFSFSLLK 1036
Score = 75.9 bits (185), Expect = 2e-13
Identities = 50/156 (32%), Positives = 76/156 (48%), Gaps = 5/156 (3%)
Query: 52 VNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKIL 111
VN D+ G T LH AA + + LLQ++A N D+ G + AA G V+ L
Sbjct: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
Query: 112 IHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTI---RNSKLETPLDLA 168
++ G + V ++N TALH A GH + ++L E D + NS L+ PL +A
Sbjct: 911 LYRGKADLTVLDEN--KNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIA 968
Query: 169 ALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARN 204
A G VV+ ++S +++ + HTP A N
Sbjct: 969 ARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN 1004
Score = 74.3 bits (181), Expect = 7e-13
Identities = 62/228 (27%), Positives = 103/228 (45%), Gaps = 47/228 (20%)
Query: 63 LHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVN 122
LH AA NGH + + L + + +V D+KG + LA +G E V++L HG S +
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGAS--ALI 646
Query: 123 EQNNENETALHCAAQYGHSEVVAVLLE-----ELTDPTIRNSKLETPLDLAALYGRLRVV 177
++ T LH AA GH++ + +L++ ++TD + ++ +TPL LA + G + V
Sbjct: 647 KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITD--VMDAYGQTPLMLAIMNGHVDCV 704
Query: 178 KMIISA--------------------------------HPNLMSCNTRK-HTPLHLAARN 204
+++ H + C K TP+HLA+
Sbjct: 705 HLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASAC 764
Query: 205 GHKAVVQVLLEAG-----MDVSCQTEKGSALHEAALFGKVDVVRVLLE 247
GH AV++ LL+A +D S +H A+ G D + +LLE
Sbjct: 765 GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812
Score = 73.2 bits (178), Expect = 1e-12
Identities = 70/248 (28%), Positives = 110/248 (44%), Gaps = 34/248 (13%)
Query: 40 LSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLA 99
LSN + G ++N D+ G T LH AA G+ + + LL A D G P+H A
Sbjct: 404 LSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463
Query: 100 AWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAA---QYGHSE-------------- 142
A G + L+ G + VNE + + + LH AA Y +E
Sbjct: 464 AANGSYQCAVTLVTAG---AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEP 520
Query: 143 -----------VVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSC- 190
+ LL+ DP++R+ + T + AA YG + +++++ N +
Sbjct: 521 LKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDV 580
Query: 191 -NTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLET 248
+T +PLHLAA NGH ++ L E +++ + KG +AL A G + V VL
Sbjct: 581 ESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAH 640
Query: 249 GIDANIKD 256
G A IK+
Sbjct: 641 GASALIKE 648
Score = 72.0 bits (175), Expect = 3e-12
Identities = 68/248 (27%), Positives = 111/248 (44%), Gaps = 16/248 (6%)
Query: 56 DSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHG 115
D+ G T L A +NGH D V LL+ ++ + AD +G +H A G + + L+ H
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDH- 743
Query: 116 PSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEEL--TDPTIRNSKLE--TPLDLAALY 171
+ V ++ + T +H A+ GH+ V+ LL+ TDP +P+ A+
Sbjct: 744 --DAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYT 801
Query: 172 GRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEA--GMDVSCQTEKG-S 228
G +++++ H TPLH A N + ++LL A V+ + KG +
Sbjct: 802 GHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRT 860
Query: 229 ALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGV 288
LH AA V +R+LL+ + N D GRT L E+ +++ G
Sbjct: 861 PLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL-----LYRGK 915
Query: 289 GRSTVLEE 296
TVL+E
Sbjct: 916 ADLTVLDE 923
Score = 71.6 bits (174), Expect = 4e-12
Identities = 62/227 (27%), Positives = 106/227 (46%), Gaps = 6/227 (2%)
Query: 44 LSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKG 103
L + +G + D G TALH A+ G +D + LL ++A D KG PIHLA+ G
Sbjct: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765
Query: 104 DVEIVKILIHHGPSHSRVNE-QNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLE 162
+++ L+ S ++ + + +H A+ GH + + +LLE + +
Sbjct: 766 HTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF- 824
Query: 163 TPLDLAALYGRLRVVKMIISA--HPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDV 220
TPL A + + +M++ A + S + + TPLH AA + + +++LL+ +V
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEV 884
Query: 221 SCQTEKG-SALHEAALFGKVDVVRVLLETG-IDANIKDSLGRTVLDI 265
+ G +AL AA G+ V LL G D + D T L +
Sbjct: 885 NATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHL 931
Score = 71.2 bits (173), Expect = 6e-12
Identities = 69/253 (27%), Positives = 105/253 (41%), Gaps = 36/253 (14%)
Query: 36 GPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFP 95
G + NLL + G ++ D G T LH+AA NG + L+ A N AD KG P
Sbjct: 434 GNVECLNLL-LSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSP 492
Query: 96 IHLAAWKGDVEIVKILIHHGPSHSRVNE----------------------------QNNE 127
+H AA + H PS E ++ +
Sbjct: 493 LHYAAASDTYRRAE---PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQ 549
Query: 128 NETALHCAAQYGHSEVVAVLLEELTD--PTIRNSKLETPLDLAALYGRLRVVKMIISAHP 185
TA+H AA YG+ + + +LLE + + ++ +PL LAA G +K +
Sbjct: 550 GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLV 609
Query: 186 NLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMD--VSCQTEKGSALHEAALFGKVDVVR 243
NL + + T L LA G V+VL G + + K + LH AA G D +
Sbjct: 610 NLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLH 669
Query: 244 VLLETGIDANIKD 256
+L+++G A+I D
Sbjct: 670 LLIDSGERADITD 682
Score = 59.7 bits (143), Expect = 2e-08
Identities = 59/237 (24%), Positives = 101/237 (42%), Gaps = 46/237 (19%)
Query: 95 PIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP 154
P+ A + DVE V+ L+ +N + E T LH AA G ++ +LL +
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQ---KENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
Query: 155 TIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARN---------- 204
+++ TPL AA +V+ ++++ ++ + + TPLH+AA N
Sbjct: 68 NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALA 127
Query: 205 -----------------------GHKAVVQVLLEAGMDVS-CQTEKGSALHEAALFGKVD 240
GH V +LL G ++ C ++ LH AA G ++
Sbjct: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE 187
Query: 241 VVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEP 297
V+++L+ G D KD G +L H + S QI + +YL +G ++EP
Sbjct: 188 VLKLLVARGADLGCKDRKGYGLL-----HTAAASGQIEVV--KYLLRMGAE--IDEP 235
Score = 48.5 bits (114), Expect = 4e-05
Identities = 37/131 (28%), Positives = 61/131 (46%), Gaps = 1/131 (0%)
Query: 162 ETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVS 221
+ PL A + V+ ++S N+ + + TPLH AA G ++Q+LL +G +V+
Sbjct: 9 QPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN 68
Query: 222 CQ-TEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATL 280
+ T + LH AA V+ +LL D N +D L +T L + + + K +
Sbjct: 69 AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
Query: 281 LQEYLEGVGRS 291
L L RS
Sbjct: 129 LLSSLNVADRS 139
Score = 32.7 bits (73), Expect = 2.2
Identities = 19/54 (35%), Positives = 27/54 (50%)
Query: 52 VNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDV 105
+N T+S+ LH AA NG +V LL + A+ D +G+ P A DV
Sbjct: 954 INATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDV 1007
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 111 bits (277), Expect = 5e-24
Identities = 107/391 (27%), Positives = 185/391 (47%), Gaps = 36/391 (9%)
Query: 4 DQELLEAARTGNVALVEKLL-----------SGRKGGILGGGSGPLPLSNLLSIWRGPNV 52
++EL++AA G+VA VE LL +G +G + + LL + + +V
Sbjct: 432 NEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLL-LKQNVDV 490
Query: 53 NCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILI 112
D G A+HHAA ++ L + A N + + P+H+A KG +++VK L+
Sbjct: 491 EAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLL 550
Query: 113 HHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYG 172
G S Q++E +T LH A +++AVLLE D TI N+ L AAL G
Sbjct: 551 DFGCHPSL---QDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRG 607
Query: 173 RLRVVKMIISAHPNLMSCNTRK---HTPLHLAARNGHKAVVQVLLEAG---MDVSCQTEK 226
+++++S P + +K +T LHLAA N H V ++L+ G +D+ +
Sbjct: 608 NPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQ-NVNQ 666
Query: 227 GSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL-DILKEHPSQKSLQIATLLQEYL 285
+ALH A +VR+L+ G +I+D G T L + L+ H + Q+ + +
Sbjct: 667 QTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL-----QDM 721
Query: 286 EGVGRSTVLEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSF 345
+ VG+ EP ++ T I ++K + ++ L+ ++ + +K S
Sbjct: 722 QDVGKVDAAWEP-----SKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSP 776
Query: 346 EDLCHTISDHYLDNLSKISEEEL-GKNGSQS 375
DLC + L+K +E++ G+ GS+S
Sbjct: 777 LDLCP--DPNLCKALAKCHKEKVSGQVGSRS 805
Score = 74.3 bits (181), Expect = 7e-13
Identities = 63/232 (27%), Positives = 115/232 (49%), Gaps = 11/232 (4%)
Query: 57 SSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGP 116
+S +A+ +A+ ++ KL + + S ++ + + AA GDV V+ L+
Sbjct: 401 ASAGSAISNASGERLSQLLKKLFETQESGDLNEE-----LVKAAANGDVAKVEDLLKRPD 455
Query: 117 SHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRV 176
VN Q TA+ A+Q GH +++ +LL++ D + + + AA V
Sbjct: 456 VD--VNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAV 512
Query: 177 VKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAAL 235
++++ +L + N R+ TPLH+A GH VV+ LL+ G S Q +G + LH+A
Sbjct: 513 IEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAIS 572
Query: 236 FGKVDVVRVLLETGIDANIKDSLGRTVLD--ILKEHPSQKSLQIATLLQEYL 285
+ D++ VLLE G D I ++ G L L+ +PS + ++ L + ++
Sbjct: 573 KKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWI 624
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 111 bits (277), Expect = 5e-24
Identities = 90/299 (30%), Positives = 147/299 (49%), Gaps = 40/299 (13%)
Query: 2 GKDQELLEAARTGNVALVEKL----------LSGRKGGILGGGSG---PLPLSNLLSIWR 48
G +ELLEA R G+V+ V++L ++GRK L +G + +LL +
Sbjct: 181 GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQM-- 238
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G NV+ D G LH+A GH ++V LL A N DN Y P+H AA KG +++
Sbjct: 239 GANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVC 298
Query: 109 KILIHHGPSHSRVNEQNNENETALHC--------------------AAQYGHSEVVAVLL 148
+L+ HG + N +N + ++AL AA+ G+ E + LL
Sbjct: 299 IVLLQHG---ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL 355
Query: 149 EEL-TDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHK 207
L + + + TPL LAA Y R+R+V++++ ++ + + PLH A GH
Sbjct: 356 TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHY 415
Query: 208 AVVQVLLEAGMDVSC-QTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
V ++LL+ G V+ + + LHEAA +V+V +LL G D + + G++ +D+
Sbjct: 416 EVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDM 474
Score = 102 bits (253), Expect = 3e-21
Identities = 87/293 (29%), Positives = 139/293 (47%), Gaps = 32/293 (10%)
Query: 4 DQELLEAARTGNVALVEKLLSGRKGG---ILGGGSGPLPLS---NLLSI-----WRGPNV 52
D LLEA++ G++ V++L S + + G S PL + N +S+ G +V
Sbjct: 651 DYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADV 710
Query: 53 NCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILI 112
+ D G LH+A GH ++ L+++ AS NVAD + P+H AA KG EI K+L+
Sbjct: 711 HAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770
Query: 113 HHGPSHSRVNEQNN-----------------ENETALHCAAQYG-HSEVVAVLLEELTDP 154
HG ++ N N + AL AA+ G + V + E +
Sbjct: 771 KHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINC 830
Query: 155 TIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLL 214
+ TPL LAA Y L V + ++ ++ + + PLH AA GH + +L+
Sbjct: 831 RDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLI 890
Query: 215 EAGMDVSCQTEKG--SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
+ V+ T+K + LHEAA G+ + +LL G D +K+ G+T LD+
Sbjct: 891 KYNTCVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 942
Score = 90.1 bits (222), Expect = 1e-17
Identities = 89/305 (29%), Positives = 135/305 (44%), Gaps = 37/305 (12%)
Query: 3 KDQELLEAARTGNVALVEKLLS----------GRKGGIL--GGGSGPLPLSNLLSIWRGP 50
K ELLEAAR+GN + LL+ GRK L G + + LL + G
Sbjct: 335 KKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLL-LQHGA 393
Query: 51 NVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKI 110
+V+ D G LH+A GH ++ LL++ A N D + P+H AA K VE+ +
Sbjct: 394 DVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSL 453
Query: 111 LIHHGPSHSRVNEQNN-------------------ENETALHCAAQYGHSEVVAVLLEEL 151
L+ HG + VN + + L A + ++V L E+
Sbjct: 454 LLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI 513
Query: 152 TDPTIRNSKLETPLD--LAALYG-RLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKA 208
+ S ET L +A+L+ R +V ++++ N+ N TPLH+AA H
Sbjct: 514 INFKQPQSH-ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHND 572
Query: 209 VVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILK 267
V++VL + G ++ G +ALH AAL G + R+LL G D +I G T +
Sbjct: 573 VMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGN 632
Query: 268 EHPSQ 272
E Q
Sbjct: 633 EAVQQ 637
Score = 89.4 bits (220), Expect = 2e-17
Identities = 76/260 (29%), Positives = 113/260 (43%), Gaps = 45/260 (17%)
Query: 44 LSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKG 103
L + +G NVN + T LH AA H D++ L ++ A N D G +H AA G
Sbjct: 543 LLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAG 602
Query: 104 DVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLET 163
++ ++L+ +G S ++ Q AAQ G+ V +L E IR S ++
Sbjct: 603 HLQTCRLLLSYGSDPSIISLQG-------FTAAQMGNEAVQQILSE---STPIRTSDVDY 652
Query: 164 PLDLAALYGRLRVVKMIISA-HPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSC 222
L A+ G L VK + S+ + N R TPLH AA +VV+ LL G DV
Sbjct: 653 RLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
Query: 223 QTEKG----------------------------------SALHEAALFGKVDVVRVLLET 248
+ + G + LHEAA GK ++ ++LL+
Sbjct: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772
Query: 249 GIDANIKDSLGRTVLDILKE 268
G D K+ G T LD++KE
Sbjct: 773 GADPTKKNRDGNTPLDLVKE 792
Score = 61.2 bits (147), Expect = 6e-09
Identities = 49/154 (31%), Positives = 75/154 (48%), Gaps = 6/154 (3%)
Query: 59 GYTALHHAALNGHKDIVLKLLQYEASTNVADNKGY--FPIHLAAWKGDVEIVKILIHHGP 116
G AL AA G V KL E + N D +G P+HLAA ++E+ + L+ HG
Sbjct: 803 GDAALLDAAKKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGA 861
Query: 117 SHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRV 176
VN Q+ LH AA YGH ++ A+L++ T + TPL AA GR ++
Sbjct: 862 D---VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQL 918
Query: 177 VKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVV 210
++++ + N TPL LA + +A++
Sbjct: 919 CALLLAHGADPTMKNQEGQTPLDLATADDIRALL 952
Score = 34.7 bits (78), Expect = 0.58
Identities = 29/100 (29%), Positives = 39/100 (39%), Gaps = 10/100 (10%)
Query: 10 AARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLS----------IWRGPNVNCTDSSG 59
AA N+ + E LL G +PL N S I VN TD
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWA 903
Query: 60 YTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLA 99
+T LH AA G + LL + A + + +G P+ LA
Sbjct: 904 FTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 110 bits (276), Expect = 6e-24
Identities = 78/228 (34%), Positives = 124/228 (54%), Gaps = 7/228 (3%)
Query: 41 SNLLSIWRGPNVNC-TDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLA 99
S +L I+ +++ T+S+ TAL A GH+++V LL+ AS D KG+ P+ LA
Sbjct: 1064 SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILA 1123
Query: 100 AWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNS 159
A G V +V+IL+ +G +E+ + +L C+ G EVV +LL + RN
Sbjct: 1124 ATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSG--GRQEVVELLLARGANKEHRNV 1181
Query: 160 KLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRK--HTPLHLAARNGHKAVVQVLLEAG 217
TPL LAA G + ++K++++A + S K +PL LAA NGH A V++LL+ G
Sbjct: 1182 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 1241
Query: 218 MDVSCQ--TEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
D++ Q T + +AL A G+ +VV +LL+ + + G T L
Sbjct: 1242 SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL 1289
Score = 94.7 bits (234), Expect = 5e-19
Identities = 74/261 (28%), Positives = 124/261 (47%), Gaps = 16/261 (6%)
Query: 7 LLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLS----------IWRGPNVNCTD 56
L+ AA G+V +V+ LL+ + +G L+ + + G ++ +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
Query: 57 SSGYTALHHAALNGHKDIVLKLLQYEASTNVADNK-GYFPIHLAAWKGDVEIVKILIHHG 115
+G+T L A GH ++ LL+ A N N+ + LA +KG +E+V+ L+ G
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
Query: 116 PSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLR 175
+ +E TAL A GH EV +LL+ + E+PL LAA G +
Sbjct: 425 ADQEH---KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
Query: 176 VVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTE--KGSALHEA 233
+ ++I +L N +TPL AAR GH+ +V +LL G +++ QTE + +AL A
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
Query: 234 ALFGKVDVVRVLLETGIDANI 254
G ++V L++ G D +
Sbjct: 542 CCGGFLEVADFLIKAGADIEL 562
Score = 90.5 bits (223), Expect = 9e-18
Identities = 71/207 (34%), Positives = 104/207 (50%), Gaps = 8/207 (3%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G VN S + L AA GH ++ L++ AS +++GY P+ AA +G E+V
Sbjct: 457 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV 516
Query: 109 KILIHHGPSHSRVNEQNNEN-ETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDL 167
+L+ G + +N Q E ETAL A G EV L++ D + S TPL
Sbjct: 517 ALLLGQG---ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570
Query: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
AA G L +VK +++A N+ + T L A NGH V VLL+AG D+ ++E G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 228 -SALHEAALFGKVDVVRVLLETGIDAN 253
+ L +AA G V V+ L+ G + N
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVN 657
Score = 85.1 bits (209), Expect = 4e-16
Identities = 154/630 (24%), Positives = 242/630 (38%), Gaps = 117/630 (18%)
Query: 7 LLEAARTGNVALVEKLL-SGRKGGILGGGSGPLPLSNLLS----------IWRGPNVNCT 55
L+ AA G+V +VE LL +G + PLS S + RG N
Sbjct: 1120 LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 1179
Query: 56 DSSGYTALHHAALNGHKDIVLKLLQYEASTN--VADNKGYFPIHLAAWKGDVEIVKILIH 113
+ S YT L AA G+ +I+ LL A N G P+ LAA G VK+L+
Sbjct: 1180 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 1239
Query: 114 HGPSHSRVNEQNNENETALHC-------------------------------AAQYGHSE 142
G + E N L C AA G++E
Sbjct: 1240 MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1299
Query: 143 VVAVLLEELTD---PTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLH 199
V VLL++ D P + +S+ +T L +AA G + +++I ++ N + +TPL
Sbjct: 1300 VGRVLLDKGADVNAPPVPSSR-DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLW 1358
Query: 200 LAARNGHKAVVQVLLEAGMDV-SCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDS- 257
LAA GH VVQ+L++AG DV + K + L A G V VVR L++ ++ DS
Sbjct: 1359 LAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE-VNQFPSDSE 1417
Query: 258 ---LGRTVLD---ILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQET-HISS 310
T+ D + K H +S+ A Q S +LEE E +E+ ++
Sbjct: 1418 CMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLAL 1477
Query: 311 PVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGK 370
+ +K K E + L+EI+ ++++ + + + L K+ +E
Sbjct: 1478 AAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQ------AAQEKEKL-KVEDEPEVL 1530
Query: 371 NGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGFPMLAQESYPKK 430
S T++TI G S W L +G RN + + +K
Sbjct: 1531 TEPPSATTTTTI-----------------GISATWTTLAGSHGKRNNTITTTSSKRKNRK 1573
Query: 431 RNYTMEIVPSASLDTFP---SENENFLCDLMDTAVTK---------KPCSLEIARAPSPR 478
T E V D P S+ E + ++ ++ CS E + + S R
Sbjct: 1574 NKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSR 1633
Query: 479 -TDNASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLD 537
+DN S VTT +S + S V+ PK+ VS
Sbjct: 1634 KSDNHSPAVVTTTVSSKKQPS----------------------VLVTFPKEERKSVSGKA 1671
Query: 538 FHRMNHNQEYFEINTSTGCTSFTASPPASP 567
+++ N+ + CT SP +SP
Sbjct: 1672 SIKLSETISEGTSNSLSTCTKSGPSPLSSP 1701
Score = 83.2 bits (204), Expect = 1e-15
Identities = 79/273 (28%), Positives = 115/273 (42%), Gaps = 16/273 (5%)
Query: 4 DQELLEAARTGNVALVEKLL-----------SGRKGGILGGGSGPLPLSNLLSIWRGPNV 52
++ L EA G+V V KLL G L +G L+ +L
Sbjct: 235 NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294
Query: 53 NCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILI 112
+ T L AA GH IV LL ++A N + G + A G V++VK+L+
Sbjct: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
Query: 113 HHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTD-PTIRNSKLETPLDLAALY 171
G S + + N T L A GH EV +LLE T N E+ L LA
Sbjct: 355 ESGAS---IEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK 411
Query: 172 GRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEK-GSAL 230
G L +V+ ++ A + HT L A +GH V ++LL++G V+ + S L
Sbjct: 412 GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 471
Query: 231 HEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
AA G V++ +L+E G + G T L
Sbjct: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPL 504
Score = 73.6 bits (179), Expect = 1e-12
Identities = 62/189 (32%), Positives = 84/189 (44%), Gaps = 25/189 (13%)
Query: 1 MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY 60
+G L+EAA+ G++ LV+ LL+ G NV+ T ++G
Sbjct: 562 LGCSTPLMEAAQEGHLELVKYLLAA-----------------------GANVHATTATGD 598
Query: 61 TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR 120
TAL +A NGH D+ LLQ A G P+ AA G V V+ LI G + +R
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
Query: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI 180
N+ +L CA GH VV +LL DPT R T L AA G VV +
Sbjct: 659 TTANNDHTVLSLACAG--GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
Query: 181 ISAHPNLMS 189
+ NL+S
Sbjct: 717 LDYPNNLLS 725
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 110 bits (276), Expect = 6e-24
Identities = 78/228 (34%), Positives = 124/228 (54%), Gaps = 7/228 (3%)
Query: 41 SNLLSIWRGPNVNC-TDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLA 99
S +L I+ +++ T+S+ TAL A GH+++V LL+ AS D KG+ P+ LA
Sbjct: 813 SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILA 872
Query: 100 AWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNS 159
A G V +V+IL+ +G +E+ + +L C+ G EVV +LL + RN
Sbjct: 873 ATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSG--GRQEVVELLLARGANKEHRNV 930
Query: 160 KLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRK--HTPLHLAARNGHKAVVQVLLEAG 217
TPL LAA G + ++K++++A + S K +PL LAA NGH A V++LL+ G
Sbjct: 931 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990
Query: 218 MDVSCQ--TEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
D++ Q T + +AL A G+ +VV +LL+ + + G T L
Sbjct: 991 SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL 1038
Score = 94.7 bits (234), Expect = 5e-19
Identities = 74/261 (28%), Positives = 124/261 (47%), Gaps = 16/261 (6%)
Query: 7 LLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLS----------IWRGPNVNCTD 56
L+ AA G+V +V+ LL+ + +G L+ + + G ++ +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
Query: 57 SSGYTALHHAALNGHKDIVLKLLQYEASTNVADNK-GYFPIHLAAWKGDVEIVKILIHHG 115
+G+T L A GH ++ LL+ A N N+ + LA +KG +E+V+ L+ G
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
Query: 116 PSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLR 175
+ +E TAL A GH EV +LL+ + E+PL LAA G +
Sbjct: 425 ADQEH---KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
Query: 176 VVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTE--KGSALHEA 233
+ ++I +L N +TPL AAR GH+ +V +LL G +++ QTE + +AL A
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
Query: 234 ALFGKVDVVRVLLETGIDANI 254
G ++V L++ G D +
Sbjct: 542 CCGGFLEVADFLIKAGADIEL 562
Score = 90.5 bits (223), Expect = 9e-18
Identities = 71/207 (34%), Positives = 104/207 (50%), Gaps = 8/207 (3%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
G VN S + L AA GH ++ L++ AS +++GY P+ AA +G E+V
Sbjct: 457 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV 516
Query: 109 KILIHHGPSHSRVNEQNNEN-ETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDL 167
+L+ G + +N Q E ETAL A G EV L++ D + S TPL
Sbjct: 517 ALLLGQG---ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570
Query: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
AA G L +VK +++A N+ + T L A NGH V VLL+AG D+ ++E G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 228 -SALHEAALFGKVDVVRVLLETGIDAN 253
+ L +AA G V V+ L+ G + N
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVN 657
Score = 85.1 bits (209), Expect = 4e-16
Identities = 154/630 (24%), Positives = 242/630 (38%), Gaps = 117/630 (18%)
Query: 7 LLEAARTGNVALVEKLL-SGRKGGILGGGSGPLPLSNLLS----------IWRGPNVNCT 55
L+ AA G+V +VE LL +G + PLS S + RG N
Sbjct: 869 LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 928
Query: 56 DSSGYTALHHAALNGHKDIVLKLLQYEASTN--VADNKGYFPIHLAAWKGDVEIVKILIH 113
+ S YT L AA G+ +I+ LL A N G P+ LAA G VK+L+
Sbjct: 929 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 988
Query: 114 HGPSHSRVNEQNNENETALHC-------------------------------AAQYGHSE 142
G + E N L C AA G++E
Sbjct: 989 MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1048
Query: 143 VVAVLLEELTD---PTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLH 199
V VLL++ D P + +S+ +T L +AA G + +++I ++ N + +TPL
Sbjct: 1049 VGRVLLDKGADVNAPPVPSSR-DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLW 1107
Query: 200 LAARNGHKAVVQVLLEAGMDV-SCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDS- 257
LAA GH VVQ+L++AG DV + K + L A G V VVR L++ ++ DS
Sbjct: 1108 LAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE-VNQFPSDSE 1166
Query: 258 ---LGRTVLD---ILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQET-HISS 310
T+ D + K H +S+ A Q S +LEE E +E+ ++
Sbjct: 1167 CMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLAL 1226
Query: 311 PVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGK 370
+ +K K E + L+EI+ ++++ + + + L K+ +E
Sbjct: 1227 AAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQ------AAQEKEKL-KVEDEPEVL 1279
Query: 371 NGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGFPMLAQESYPKK 430
S T++TI G S W L +G RN + + +K
Sbjct: 1280 TEPPSATTTTTI-----------------GISATWTTLAGSHGKRNNTITTTSSKRKNRK 1322
Query: 431 RNYTMEIVPSASLDTFP---SENENFLCDLMDTAVTK---------KPCSLEIARAPSPR 478
T E V D P S+ E + ++ ++ CS E + + S R
Sbjct: 1323 NKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSR 1382
Query: 479 -TDNASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLD 537
+DN S VTT +S + S V+ PK+ VS
Sbjct: 1383 KSDNHSPAVVTTTVSSKKQPS----------------------VLVTFPKEERKSVSGKA 1420
Query: 538 FHRMNHNQEYFEINTSTGCTSFTASPPASP 567
+++ N+ + CT SP +SP
Sbjct: 1421 SIKLSETISEGTSNSLSTCTKSGPSPLSSP 1450
Score = 83.2 bits (204), Expect = 1e-15
Identities = 79/273 (28%), Positives = 115/273 (42%), Gaps = 16/273 (5%)
Query: 4 DQELLEAARTGNVALVEKLL-----------SGRKGGILGGGSGPLPLSNLLSIWRGPNV 52
++ L EA G+V V KLL G L +G L+ +L
Sbjct: 235 NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294
Query: 53 NCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILI 112
+ T L AA GH IV LL ++A N + G + A G V++VK+L+
Sbjct: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
Query: 113 HHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTD-PTIRNSKLETPLDLAALY 171
G S + + N T L A GH EV +LLE T N E+ L LA
Sbjct: 355 ESGAS---IEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK 411
Query: 172 GRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEK-GSAL 230
G L +V+ ++ A + HT L A +GH V ++LL++G V+ + S L
Sbjct: 412 GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 471
Query: 231 HEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
AA G V++ +L+E G + G T L
Sbjct: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPL 504
Score = 73.6 bits (179), Expect = 1e-12
Identities = 62/189 (32%), Positives = 84/189 (44%), Gaps = 25/189 (13%)
Query: 1 MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY 60
+G L+EAA+ G++ LV+ LL+ G NV+ T ++G
Sbjct: 562 LGCSTPLMEAAQEGHLELVKYLLAA-----------------------GANVHATTATGD 598
Query: 61 TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR 120
TAL +A NGH D+ LLQ A G P+ AA G V V+ LI G + +R
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
Query: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI 180
N+ +L CA GH VV +LL DPT R T L AA G VV +
Sbjct: 659 TTANNDHTVLSLACAG--GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
Query: 181 ISAHPNLMS 189
+ NL+S
Sbjct: 717 LDYPNNLLS 725
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 110 bits (275), Expect = 8e-24
Identities = 87/287 (30%), Positives = 130/287 (45%), Gaps = 15/287 (5%)
Query: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEAST-NVADNKGYFPIHLAAWKGDVEI 107
G V D+SG T LH AA GH ++V LL + A + G PIH AA KGD
Sbjct: 94 GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPS 153
Query: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEEL-TDPTIRNSKLETPLD 166
+++L+ H P VN Q T L+ A Q GH EV L++E DP R TPL
Sbjct: 154 LRLLVEHYPEG--VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLH 211
Query: 167 LAALYGRLRVVKMIISAHPNLMSCNTRKH-TPLHLAARNGHKAVVQVLLEAGMDVSCQTE 225
AA G V+ ++S +S + T +H AA GH V+ LL G ++S
Sbjct: 212 AAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLW 271
Query: 226 KGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYL 285
G+ LH+AA G+++ ++L+ G + +++D G T D+ + YL
Sbjct: 272 GGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADL-------SDFNGHSHCTRYL 324
Query: 286 EGVGRSTVLEEPVQEDATQETHISSP---VESPSQKTKSETVTGELS 329
V +V + D + E P + SP+ + + +LS
Sbjct: 325 RTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLS 371
Score = 46.2 bits (108), Expect = 2e-04
Identities = 52/179 (29%), Positives = 78/179 (43%), Gaps = 7/179 (3%)
Query: 135 AAQYGHSEVVAVL-LEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTR 193
AA+ G +V+ L L P++R+ P+ AA G+L ++ ++ + R
Sbjct: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
Query: 194 KH-TPLHLAARNGHKAVVQVLL-EAGMDVSCQTEKG-SALHEAALFGKVDVVRVLL-ETG 249
TP H A+ GH A +Q LL + G V + G + LH AA FG +VV LL G
Sbjct: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
Query: 250 IDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQETHI 308
D +G + SL++ L++ Y EGV T A QE H+
Sbjct: 129 GDPTAATDMGALPIHYAAAKGDFPSLRL--LVEHYPEGVNAQTKNGATPLYLACQEGHL 185
Score = 43.9 bits (102), Expect = 0.001
Identities = 37/138 (26%), Positives = 61/138 (44%), Gaps = 5/138 (3%)
Query: 36 GPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQ-YEASTNVADNKGYF 94
G L ++ L G + + G T LH AA GH +++ L+ + S + D G
Sbjct: 183 GHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGAT 242
Query: 95 PIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP 154
+H AA +G +++ L+ HG S + T LH AA+ G E +L+ +
Sbjct: 243 AMHFAASRGHTKVLSWLLLHGGEIS----ADLWGGTPLHDAAENGELECCQILVVNGAEL 298
Query: 155 TIRNSKLETPLDLAALYG 172
+R+ T DL+ G
Sbjct: 299 DVRDRDGYTAADLSDFNG 316
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,545,813
Number of Sequences: 37866
Number of extensions: 2526603
Number of successful extensions: 12698
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 349
Number of HSP's successfully gapped in prelim test: 152
Number of HSP's that attempted gapping in prelim test: 7449
Number of HSP's gapped (non-prelim): 2265
length of query: 1248
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1134
effective length of database: 13,930,794
effective search space: 15797520396
effective search space used: 15797520396
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.