Guide to the Human Genome
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Search of human proteins with 4885215

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885215 v-erb-a erythroblastic leukemia viral oncogene
homolog 4 isoform JM-a/CVT-1 precursor [Homo sapiens]
         (1308 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo...  2750   0.0  
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo...  2705   0.0  
gi|29725609 epidermal growth factor receptor isoform a precursor...  1263   0.0  
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]                1206   0.0  
gi|54792096 erbB-2 isoform a [Homo sapiens]                          1131   0.0  
gi|54792098 erbB-2 isoform b [Homo sapiens]                          1120   0.0  
gi|41327736 epidermal growth factor receptor isoform d precursor...   631   e-180
gi|41327732 epidermal growth factor receptor isoform b precursor...   631   e-180
gi|41327734 epidermal growth factor receptor isoform c precursor...   390   e-108
gi|32967311 ephrin receptor EphA2 [Homo sapiens]                      226   8e-59
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]   220   6e-57
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]   220   6e-57
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo...   214   3e-55
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo...   214   3e-55
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo...   214   3e-55
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo...   213   7e-55
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             213   1e-54
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               213   1e-54
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             213   1e-54
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             213   1e-54
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             213   1e-54
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap...   211   4e-54
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap...   211   4e-54
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]             211   5e-54
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   209   1e-53
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   209   1e-53
gi|4758280 ephrin receptor EphA4 [Homo sapiens]                       206   1e-52
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi...   206   2e-52
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]          205   3e-52
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]           205   3e-52

>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
            isoform JM-a/CVT-1 precursor [Homo sapiens]
          Length = 1308

 Score = 2750 bits (7129), Expect = 0.0
 Identities = 1308/1308 (100%), Positives = 1308/1308 (100%)

Query: 1    MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60
            MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM
Sbjct: 1    MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60

Query: 61   GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120
            GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF
Sbjct: 61   GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120

Query: 121  LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180
            LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST
Sbjct: 121  LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180

Query: 181  NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240
            NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG
Sbjct: 181  NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240

Query: 241  PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300
            PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD
Sbjct: 241  PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300

Query: 301  SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360
            SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT
Sbjct: 301  SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360

Query: 361  KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420
            KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL
Sbjct: 361  KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420

Query: 421  VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 480
            VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST
Sbjct: 421  VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 480

Query: 481  INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 540
            INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD
Sbjct: 481  INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 540

Query: 541  GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 600
            GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA
Sbjct: 541  GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 600

Query: 601  NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG 660
            NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG
Sbjct: 601  NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG 660

Query: 661  LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 720
            LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR
Sbjct: 661  LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 720

Query: 721  VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
            VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL
Sbjct: 721  VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780

Query: 781  VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
            VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV
Sbjct: 781  VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840

Query: 841  HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
            HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ
Sbjct: 841  HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900

Query: 901  SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
            SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID
Sbjct: 901  SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960

Query: 961  ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
            ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE
Sbjct: 961  ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020

Query: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP 1080
            EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP
Sbjct: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP 1080

Query: 1081 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS 1140
            YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS
Sbjct: 1081 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS 1140

Query: 1141 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1200
            PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED
Sbjct: 1141 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1200

Query: 1201 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1260
            EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ
Sbjct: 1201 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1260

Query: 1261 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1308
            EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
Sbjct: 1261 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1308


>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog 4
            isoform JM-a/CVT-2 precursor [Homo sapiens]
          Length = 1292

 Score = 2705 bits (7012), Expect = 0.0
 Identities = 1292/1308 (98%), Positives = 1292/1308 (98%), Gaps = 16/1308 (1%)

Query: 1    MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60
            MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM
Sbjct: 1    MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60

Query: 61   GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120
            GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF
Sbjct: 61   GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120

Query: 121  LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180
            LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST
Sbjct: 121  LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180

Query: 181  NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240
            NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG
Sbjct: 181  NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240

Query: 241  PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300
            PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD
Sbjct: 241  PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300

Query: 301  SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360
            SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT
Sbjct: 301  SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360

Query: 361  KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420
            KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL
Sbjct: 361  KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420

Query: 421  VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 480
            VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST
Sbjct: 421  VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 480

Query: 481  INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 540
            INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD
Sbjct: 481  INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 540

Query: 541  GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 600
            GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA
Sbjct: 541  GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 600

Query: 601  NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG 660
            NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG
Sbjct: 601  NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG 660

Query: 661  LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 720
            LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR
Sbjct: 661  LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 720

Query: 721  VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
            VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL
Sbjct: 721  VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780

Query: 781  VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
            VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV
Sbjct: 781  VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840

Query: 841  HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
            HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ
Sbjct: 841  HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900

Query: 901  SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
            SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID
Sbjct: 901  SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960

Query: 961  ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
            ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE
Sbjct: 961  ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020

Query: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP 1080
            EYLVPQAFNIPPPIYTSRARIDSNR                NQFVYRDGGFAAEQGVSVP
Sbjct: 1021 EYLVPQAFNIPPPIYTSRARIDSNR----------------NQFVYRDGGFAAEQGVSVP 1064

Query: 1081 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS 1140
            YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS
Sbjct: 1065 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS 1124

Query: 1141 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1200
            PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED
Sbjct: 1125 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1184

Query: 1201 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1260
            EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ
Sbjct: 1185 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1244

Query: 1261 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1308
            EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
Sbjct: 1245 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1292


>gi|29725609 epidermal growth factor receptor isoform a precursor
            [Homo sapiens]
          Length = 1210

 Score = 1263 bits (3269), Expect = 0.0
 Identities = 645/1267 (50%), Positives = 817/1267 (64%), Gaps = 99/1267 (7%)

Query: 24   DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
            + + VC GT NKL+ L   E  + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 26   EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85

Query: 84   TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
             GYVL+ALN    +PLENL+IIRG   YE+ YALA+  NY  D N  GL+EL ++NL EI
Sbjct: 86   AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143

Query: 143  LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
            L+G V    N  LC  ++I W+DIV + + SN+++   N    C +C  SC  G CWG  
Sbjct: 144  LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203

Query: 202  ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
            E +CQ LT+ +CA+QC GRC G   SDCCH +CA GC+GP+++DC  C  F D   C   
Sbjct: 204  EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263

Query: 262  CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
            CP   +YNPTT+Q++ N   KY++GA CVKKCP N+VV D  SCVRAC +   E+EE+G+
Sbjct: 264  CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323

Query: 321  KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
            + CK C   C K C+GIG G    + +++++NI  F NCT I+G+L  L     GD +  
Sbjct: 324  RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383

Query: 381  IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQ 440
               +DP++L++ +TV+EITGFL IQ+WP N TD   F NL  I GR    G   L +   
Sbjct: 384  TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL 443

Query: 441  GITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 500
             ITSL  +SLKEIS G++ I+ N NLCY +TINW  LF T  Q+  I  NR   +C A G
Sbjct: 444  NITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATG 503

Query: 501  MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCE 560
             VC+ LCS +GCWGP P  C+SCR  SRGR C++ CNL +GE REF   S C++C P+C 
Sbjct: 504  QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECL 563

Query: 561  KMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANS-FIFKYADPDRECHPCHP 619
                 + TC G GPDNC +C+H+ DGP+CV+ CP G+ G N+  ++KYAD    CH CHP
Sbjct: 564  PQAMNI-TCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 622

Query: 620  NCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKS 679
            NCT GC GP    C   P  G        + P IA G++G L +L++V L   +++RR+ 
Sbjct: 623  NCTYGCTGPGLEGC---PTNG-------PKIPSIATGMVGALLLLLVVALGIGLFMRRRH 672

Query: 680  IKKKRALRRFL-ETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWV 738
            I +KR LRR L E ELVEPLTPSG APNQA LRILKETE K++KVLGSGAFGTVYKG+W+
Sbjct: 673  IVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWI 732

Query: 739  PEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQL 798
            PEGE VKIPVAIK L E T PKAN E +DEA +MAS+D+PH+ RLLG+CL+ T+QL+TQL
Sbjct: 733  PEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQL 792

Query: 799  MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVK 858
            MP GCLL+YV EHKDNIGSQ LLNWCVQIAKGM YLE+RRLVHRDLAARNVLVK+P HVK
Sbjct: 793  MPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK 852

Query: 859  ITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGG 918
            ITDFGLA+LL  +EKEY+A+GGK+PIKWMALE I +R +THQSDVWSYGVT+WELMTFG 
Sbjct: 853  ITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS 912

Query: 919  KPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMA 978
            KPYDGIP  EI  +LEKGERLPQPPICTIDVYM+MVKCWMIDADSRPKF+EL  EFS+MA
Sbjct: 913  KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMA 972

Query: 979  RDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSR 1038
            RDPQRYLVIQGD+RM LPSP DS F++ L+DEED++D++DA+EYL+PQ      P  TSR
Sbjct: 973  RDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSP-STSR 1031

Query: 1039 ARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGAT 1098
              + S+ S   ++   A    +G Q                                   
Sbjct: 1032 TPLLSSLSATSNNSTVACIDRNGLQ----------------------------------- 1056

Query: 1099 AEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKP 1158
                  SC            ++EDS  QRYS+DPT         G L E+         P
Sbjct: 1057 ------SC-----------PIKEDSFLQRYSSDPT---------GALTEDSIDDTF--LP 1088

Query: 1159 KQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGK 1218
              EY+     N  V +R  G +Q   NP YHN    P  + D     P Y +  +  +G 
Sbjct: 1089 VPEYI-----NQSVPKRPAGSVQ---NPVYHNQPLNPAPSRD-----PHYQDPHSTAVGN 1135

Query: 1219 AEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIV 1278
             EYL       P      FD+P +W      + +L +PDY Q++  K   K NG  +   
Sbjct: 1136 PEYLNT---VQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKE-AKPNGIFKGST 1191

Query: 1279 AENPEYL 1285
            AEN EYL
Sbjct: 1192 AENAEYL 1198


>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
          Length = 1342

 Score = 1206 bits (3120), Expect = 0.0
 Identities = 623/1181 (52%), Positives = 792/1181 (67%), Gaps = 47/1181 (3%)

Query: 1    MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60
            M+    L V   L   A   +  +SQ+VC GT N LS   D E QY+ L K YE CEVVM
Sbjct: 1    MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM 60

Query: 61   GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120
            GNLEI    HN DLSFL+ +REVTGYVLVA+N+F  LPL NLR++RGT++Y+ ++A+ + 
Sbjct: 61   GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM 120

Query: 121  LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180
            LNY  + +  L++L L  LTEIL+GGVY+++N  LC+ DTI W+DIVR+    +  +V  
Sbjct: 121  LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVK 177

Query: 181  NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240
            +    C  CH+ C GRCWGP    CQTLT+T+CA QC+G C+GP  + CCH ECAGGCSG
Sbjct: 178  DNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSG 237

Query: 241  PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300
            P+DTDCFAC +FNDSGACV +CPQ  VYN  TFQLE N + KY YG  CV  CPHNFVVD
Sbjct: 238  PQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVD 297

Query: 301  SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360
             +SCVRACP  KMEV++NG+KMC+PC  +CPKAC+G G+GS    QTVDSSNID F+NCT
Sbjct: 298  QTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRF--QTVDSSNIDGFVNCT 355

Query: 361  KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420
            KI GNL FL+TG++GDP++ I A+DPEKLNVFRTVREITG+LNIQSWPP+M +FSVFSNL
Sbjct: 356  KILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNL 415

Query: 421  VTIGGRVLYS-GLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWT-TLF 478
             TIGGR LY+ G SLLI+K   +TSL F+SLKEISAG IYI+ N  LCY+H++NWT  L 
Sbjct: 416  TTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLR 475

Query: 479  STINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNL 538
                +R+ I+ NR   +C AEG VC+ LCSS GCWGPGP QCLSCR +SRG +C+  CN 
Sbjct: 476  GPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNF 535

Query: 539  YDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQ 598
             +GE REF + + C  C P+C+ ME G  TC+G G D C +C+HF+DGP+CV  CP G+ 
Sbjct: 536  LNGEPREFAHEAECFSCHPECQPME-GTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVL 594

Query: 599  GANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPL-IAAGV 657
            GA   I+KY D   EC PCH NCTQGC GP   DC+        TL    +T L +A  V
Sbjct: 595  GAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCL------GQTLVLIGKTHLTMALTV 648

Query: 658  IGGLFIL-VIVGLTFAVYVRRKSIKKKRALRRFLET-ELVEPLTPSGTAPNQAQLRILKE 715
            I GL ++ +++G TF +Y R + I+ KRA+RR+LE  E +EPL PS  A N+   RI KE
Sbjct: 649  IAGLVVIFMMLGGTF-LYWRGRRIQNKRAMRRYLERGESIEPLDPSEKA-NKVLARIFKE 706

Query: 716  TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM 775
            TEL+++KVLGSG FGTV+KG+W+PEGE++KIPV IK++ + +G ++     D  L + S+
Sbjct: 707  TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSL 766

Query: 776  DHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLE 835
            DH H+VRLLG+C   ++QLVTQ +P G LL++V +H+  +G QLLLNW VQIAKGM YLE
Sbjct: 767  DHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLE 826

Query: 836  ERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYR 895
            E  +VHR+LAARNVL+KSP+ V++ DFG+A LL  D+K+      K PIKWMALE IH+ 
Sbjct: 827  EHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFG 886

Query: 896  KFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVK 955
            K+THQSDVWSYGVT+WELMTFG +PY G+   E+PDLLEKGERL QP ICTIDVYMVMVK
Sbjct: 887  KYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVK 946

Query: 956  CWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKL-PSPNDSKFFQNLLDEEDLE 1014
            CWMID + RP FKELA EF+RMARDP RYLVI+ +    + P P         L+E +LE
Sbjct: 947  CWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELE 1006

Query: 1015 DMMDAEEYLVPQAFNIPPPIYTSRARI---DSNR---SEIGHSPPPAYTPMSGNQFVYRD 1068
              +D +  L  +  N+      S   +     NR   S+   SP   Y PM+        
Sbjct: 1007 PELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNL---- 1062

Query: 1069 GGFAAEQGVS-----VPYRAPTSTIPEAPVAQ--------GATAEIFDD-SCCNGTLRKP 1114
            G    E  VS      P       +P   +A         G+ AE+ +  S C    R  
Sbjct: 1063 GESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSR 1122

Query: 1115 VAPHVQEDSS--TQRYSADPTVFAPERSPRGELDEEGYMTP 1153
             +P  + DS+  +QR+S    V         E D  GY+ P
Sbjct: 1123 -SPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMP 1162



 Score = 35.0 bits (79), Expect = 0.47
 Identities = 23/90 (25%), Positives = 38/90 (42%), Gaps = 5/90 (5%)

Query: 1165 PVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKN 1224
            P E+  +++R+++G       P    A+ G   A ++   E        +      Y + 
Sbjct: 1256 PDEDYEYMNRQRDGG-----GPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARL 1310

Query: 1225 NILSMPEKAKKAFDNPDYWNHSLPPRSTLQ 1254
              L   E    AFDNPDYW+  L P++  Q
Sbjct: 1311 KTLRSLEATDSAFDNPDYWHSRLFPKANAQ 1340


>gi|54792096 erbB-2 isoform a [Homo sapiens]
          Length = 1255

 Score = 1131 bits (2925), Expect = 0.0
 Identities = 601/1282 (46%), Positives = 789/1282 (61%), Gaps = 101/1282 (7%)

Query: 25   SQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVT 84
            S  VC GT+ KL   +  E     LR  Y+ C+VV GNLE+T +  N  LSFL+ ++EV 
Sbjct: 22   STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQ 81

Query: 85   GYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNF---------GLQELG 135
            GYVL+A NQ R +PL+ LRI+RGT+L+ED YALA+  N     N          GL+EL 
Sbjct: 82   GYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQ 141

Query: 136  LKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTG 195
            L++LTEIL GGV + +N  LCY DTI W+DI        LTL+ TN S  C  C   C G
Sbjct: 142  LRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKG 201

Query: 196  -RCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFND 254
             RCWG +   CQ+LTRTVCA  C  RC GP  +DCCH +CA GC+GPK +DC AC++FN 
Sbjct: 202  SRCWGESSEDCQSLTRTVCAGGC-ARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNH 260

Query: 255  SGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFV-VDSSSCVRACPSSKM 313
            SG C   CP    YN  TF+   N   +YT+GA CV  CP+N++  D  SC   CP    
Sbjct: 261  SGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQ 320

Query: 314  EVE-ENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTG 372
            EV  E+G + C+ C+  C + C G+G   L   + V S+NI +F  C KI G+L FL   
Sbjct: 321  EVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPES 380

Query: 373  IHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGL 432
              GDP +    + PE+L VF T+ EITG+L I +WP ++ D SVF NL  I GR+L++G 
Sbjct: 381  FDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGA 440

Query: 433  SLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRK 492
              L L+  GI+ L  +SL+E+ +G   I  N++LC+ HT+ W  LF   +Q ++   NR 
Sbjct: 441  YSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRP 500

Query: 493  AENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSIC 552
             + C  EG+ C+ LC+   CWGPGP QC++C +F RG+ C+E C +  G  RE+ N   C
Sbjct: 501  EDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHC 560

Query: 553  VECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSF--IFKYADP 610
            + C P+C+  ++G +TC GP  D C  C+H+KD P CV +CP G++   S+  I+K+ D 
Sbjct: 561  LPCHPECQP-QNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDE 619

Query: 611  DRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHAR----TPLIAAGVIGGLFILVI 666
            +  C PC  NCT  C       C           P   R    T +I+A V  G+ ++V+
Sbjct: 620  EGACQPCPINCTHSCVDLDDKGC-----------PAEQRASPLTSIISAVV--GILLVVV 666

Query: 667  VGLTFAVYVRRKSIK-KKRALRRFL-ETELVEPLTPSGTAPNQAQLRILKETELKRVKVL 724
            +G+ F + ++R+  K +K  +RR L ETELVEPLTPSG  PNQAQ+RILKETEL++VKVL
Sbjct: 667  LGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVL 726

Query: 725  GSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLL 784
            GSGAFGTVYKGIW+P+GE VKIPVAIK+L E T PKAN E +DEA +MA +  P++ RLL
Sbjct: 727  GSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLL 786

Query: 785  GVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDL 844
            G+CL+ T+QLVTQLMP+GCLL++V E++  +GSQ LLNWC+QIAKGM YLE+ RLVHRDL
Sbjct: 787  GICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDL 846

Query: 845  AARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVW 904
            AARNVLVKSPNHVKITDFGLARLL+ DE EY+ADGGK+PIKWMALE I  R+FTHQSDVW
Sbjct: 847  AARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVW 906

Query: 905  SYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSR 964
            SYGVT+WELMTFG KPYDGIP REIPDLLEKGERLPQPPICTIDVYM+MVKCWMID++ R
Sbjct: 907  SYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECR 966

Query: 965  PKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLV 1024
            P+F+EL +EFSRMARDPQR++VIQ +D +   SP DS F+++LL+++D+ D++DAEEYLV
Sbjct: 967  PRFRELVSEFSRMARDPQRFVVIQNED-LGPASPLDSTFYRSLLEDDDMGDLVDAEEYLV 1025

Query: 1025 PQ-AFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQG---VSVP 1080
            PQ  F  P P                        P +G    +R    +   G   +++ 
Sbjct: 1026 PQQGFFCPDP-----------------------APGAGGMVHHRHRSSSTRSGGGDLTLG 1062

Query: 1081 YRAPTSTIPEAPVA--QGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPE 1138
                    P +P+A  +GA +++FD     G  +   +    + S  QRYS DPTV  P 
Sbjct: 1063 LEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPS 1122

Query: 1139 RSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQA-------LDNPEYHN- 1190
             +       +GY+ P+   P+ EY+N  +  P     + G L A       L+ P+  + 
Sbjct: 1123 ET-------DGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSP 1175

Query: 1191 ASNGPPK---AEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSL 1247
              NG  K   A    V  P YL        +           P     AFDN  YW+   
Sbjct: 1176 GKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPH--------PPPAFSPAFDNLYYWDQDP 1227

Query: 1248 PPRS----------TLQHPDYL 1259
            P R           T ++P+YL
Sbjct: 1228 PERGAPPSTFKGTPTAENPEYL 1249


>gi|54792098 erbB-2 isoform b [Homo sapiens]
          Length = 1225

 Score = 1120 bits (2898), Expect = 0.0
 Identities = 596/1272 (46%), Positives = 783/1272 (61%), Gaps = 101/1272 (7%)

Query: 35   KLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQF 94
            KL   +  E     LR  Y+ C+VV GNLE+T +  N  LSFL+ ++EV GYVL+A NQ 
Sbjct: 2    KLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQV 61

Query: 95   RYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNF---------GLQELGLKNLTEILNG 145
            R +PL+ LRI+RGT+L+ED YALA+  N     N          GL+EL L++LTEIL G
Sbjct: 62   RQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKG 121

Query: 146  GVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTG-RCWGPTENH 204
            GV + +N  LCY DTI W+DI        LTL+ TN S  C  C   C G RCWG +   
Sbjct: 122  GVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSED 181

Query: 205  CQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQ 264
            CQ+LTRTVCA  C  RC GP  +DCCH +CA GC+GPK +DC AC++FN SG C   CP 
Sbjct: 182  CQSLTRTVCAGGC-ARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPA 240

Query: 265  TFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFV-VDSSSCVRACPSSKMEVE-ENGIKM 322
               YN  TF+   N   +YT+GA CV  CP+N++  D  SC   CP    EV  E+G + 
Sbjct: 241  LVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQR 300

Query: 323  CKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIE 382
            C+ C+  C + C G+G   L   + V S+NI +F  C KI G+L FL     GDP +   
Sbjct: 301  CEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA 360

Query: 383  AIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGI 442
             + PE+L VF T+ EITG+L I +WP ++ D SVF NL  I GR+L++G   L L+  GI
Sbjct: 361  PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI 420

Query: 443  TSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMV 502
            + L  +SL+E+ +G   I  N++LC+ HT+ W  LF   +Q ++   NR  + C  EG+ 
Sbjct: 421  SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLA 480

Query: 503  CNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKM 562
            C+ LC+   CWGPGP QC++C +F RG+ C+E C +  G  RE+ N   C+ C P+C+  
Sbjct: 481  CHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQP- 539

Query: 563  EDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSF--IFKYADPDRECHPCHPN 620
            ++G +TC GP  D C  C+H+KD P CV +CP G++   S+  I+K+ D +  C PC  N
Sbjct: 540  QNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPIN 599

Query: 621  CTQGCNGPTSHDCIYYPWTGHSTLPQHAR----TPLIAAGVIGGLFILVIVGLTFAVYVR 676
            CT  C       C           P   R    T +I+A V  G+ ++V++G+ F + ++
Sbjct: 600  CTHSCVDLDDKGC-----------PAEQRASPLTSIISAVV--GILLVVVLGVVFGILIK 646

Query: 677  RKSIK-KKRALRRFL-ETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYK 734
            R+  K +K  +RR L ETELVEPLTPSG  PNQAQ+RILKETEL++VKVLGSGAFGTVYK
Sbjct: 647  RRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYK 706

Query: 735  GIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQL 794
            GIW+P+GE VKIPVAIK+L E T PKAN E +DEA +MA +  P++ RLLG+CL+ T+QL
Sbjct: 707  GIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQL 766

Query: 795  VTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSP 854
            VTQLMP+GCLL++V E++  +GSQ LLNWC+QIAKGM YLE+ RLVHRDLAARNVLVKSP
Sbjct: 767  VTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSP 826

Query: 855  NHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELM 914
            NHVKITDFGLARLL+ DE EY+ADGGK+PIKWMALE I  R+FTHQSDVWSYGVT+WELM
Sbjct: 827  NHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELM 886

Query: 915  TFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEF 974
            TFG KPYDGIP REIPDLLEKGERLPQPPICTIDVYM+MVKCWMID++ RP+F+EL +EF
Sbjct: 887  TFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF 946

Query: 975  SRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQ-AFNIPPP 1033
            SRMARDPQR++VIQ +D +   SP DS F+++LL+++D+ D++DAEEYLVPQ  F  P P
Sbjct: 947  SRMARDPQRFVVIQNED-LGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDP 1005

Query: 1034 IYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQG---VSVPYRAPTSTIPE 1090
                                    P +G    +R    +   G   +++         P 
Sbjct: 1006 -----------------------APGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPR 1042

Query: 1091 APVA--QGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEE 1148
            +P+A  +GA +++FD     G  +   +    + S  QRYS DPTV  P  +       +
Sbjct: 1043 SPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSET-------D 1095

Query: 1149 GYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQA-------LDNPEYHN-ASNGPPK--- 1197
            GY+ P+   P+ EY+N  +  P     + G L A       L+ P+  +   NG  K   
Sbjct: 1096 GYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVF 1155

Query: 1198 AEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRS------ 1251
            A    V  P YL        +           P     AFDN  YW+   P R       
Sbjct: 1156 AFGGAVENPEYLTPQGGAAPQPH--------PPPAFSPAFDNLYYWDQDPPERGAPPSTF 1207

Query: 1252 ----TLQHPDYL 1259
                T ++P+YL
Sbjct: 1208 KGTPTAENPEYL 1219


>gi|41327736 epidermal growth factor receptor isoform d precursor
           [Homo sapiens]
          Length = 705

 Score =  631 bits (1627), Expect = e-180
 Identities = 293/605 (48%), Positives = 392/605 (64%), Gaps = 7/605 (1%)

Query: 24  DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
           + + VC GT NKL+ L   E  + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 26  EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85

Query: 84  TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
            GYVL+ALN    +PLENL+IIRG   YE+ YALA+  NY  D N  GL+EL ++NL EI
Sbjct: 86  AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143

Query: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
           L+G V    N  LC  ++I W+DIV + + SN+++   N    C +C  SC  G CWG  
Sbjct: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203

Query: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
           E +CQ LT+ +CA+QC GRC G   SDCCH +CA GC+GP+++DC  C  F D   C   
Sbjct: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263

Query: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
           CP   +YNPTT+Q++ N   KY++GA CVKKCP N+VV D  SCVRAC +   E+EE+G+
Sbjct: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323

Query: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
           + CK C   C K C+GIG G    + +++++NI  F NCT I+G+L  L     GD +  
Sbjct: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383

Query: 381 IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQ 440
              +DP++L++ +TV+EITGFL IQ+WP N TD   F NL  I GR    G   L +   
Sbjct: 384 TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL 443

Query: 441 GITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 500
            ITSL  +SLKEIS G++ I+ N NLCY +TINW  LF T  Q+  I  NR   +C A G
Sbjct: 444 NITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATG 503

Query: 501 MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCE 560
            VC+ LCS +GCWGP P  C+SCR  SRGR C++ CNL +GE REF   S C++C P+C 
Sbjct: 504 QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECL 563

Query: 561 KMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA-NSFIFKYADPDRECHPCHP 619
                 +TC G GPDNC +C+H+ DGP+CV+ CP G+ G  N+ ++KYAD    CH CHP
Sbjct: 564 PQAMN-ITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 622

Query: 620 NCTQG 624
           NCT G
Sbjct: 623 NCTYG 627



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 74/320 (23%), Positives = 115/320 (35%), Gaps = 83/320 (25%)

Query: 356 FINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFS 415
           F NC  + GNL       + D            L+  +T++E+ G++ I     N  +  
Sbjct: 55  FNNCEVVLGNLEITYVQRNYD------------LSFLKTIQEVAGYVLIAL---NTVERI 99

Query: 416 VFSNLVTIGGRVLYSG------LSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY 469
              NL  I G + Y        LS     + G+  L  ++L+EI  G +  ++N  LC  
Sbjct: 100 PLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV 159

Query: 470 HTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG 529
            +I W  + S+     +   +   +N       C+  C +  CWG G + C    +    
Sbjct: 160 ESIQWRDIVSS---DFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKI--- 213

Query: 530 RICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKD---- 585
            IC + C+   G  R  ++ S C  C  QC         C GP   +C  C  F+D    
Sbjct: 214 -ICAQQCS---GRCRG-KSPSDC--CHNQCAA------GCTGPRESDCLVCRKFRDEATC 260

Query: 586 ---------------------------GPNCVEKCPDGLQ-----------GANSFIFKY 607
                                      G  CV+KCP               GA+S+  + 
Sbjct: 261 KDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEME- 319

Query: 608 ADPDRECHPCHPNCTQGCNG 627
            D  R+C  C   C + CNG
Sbjct: 320 EDGVRKCKKCEGPCRKVCNG 339


>gi|41327732 epidermal growth factor receptor isoform b precursor
           [Homo sapiens]
          Length = 628

 Score =  631 bits (1627), Expect = e-180
 Identities = 293/605 (48%), Positives = 392/605 (64%), Gaps = 7/605 (1%)

Query: 24  DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
           + + VC GT NKL+ L   E  + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 26  EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85

Query: 84  TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
            GYVL+ALN    +PLENL+IIRG   YE+ YALA+  NY  D N  GL+EL ++NL EI
Sbjct: 86  AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143

Query: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
           L+G V    N  LC  ++I W+DIV + + SN+++   N    C +C  SC  G CWG  
Sbjct: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203

Query: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
           E +CQ LT+ +CA+QC GRC G   SDCCH +CA GC+GP+++DC  C  F D   C   
Sbjct: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263

Query: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
           CP   +YNPTT+Q++ N   KY++GA CVKKCP N+VV D  SCVRAC +   E+EE+G+
Sbjct: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323

Query: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
           + CK C   C K C+GIG G    + +++++NI  F NCT I+G+L  L     GD +  
Sbjct: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383

Query: 381 IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQ 440
              +DP++L++ +TV+EITGFL IQ+WP N TD   F NL  I GR    G   L +   
Sbjct: 384 TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL 443

Query: 441 GITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 500
            ITSL  +SLKEIS G++ I+ N NLCY +TINW  LF T  Q+  I  NR   +C A G
Sbjct: 444 NITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATG 503

Query: 501 MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCE 560
            VC+ LCS +GCWGP P  C+SCR  SRGR C++ CNL +GE REF   S C++C P+C 
Sbjct: 504 QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECL 563

Query: 561 KMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA-NSFIFKYADPDRECHPCHP 619
                 +TC G GPDNC +C+H+ DGP+CV+ CP G+ G  N+ ++KYAD    CH CHP
Sbjct: 564 PQAMN-ITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 622

Query: 620 NCTQG 624
           NCT G
Sbjct: 623 NCTYG 627



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 74/320 (23%), Positives = 115/320 (35%), Gaps = 83/320 (25%)

Query: 356 FINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFS 415
           F NC  + GNL       + D            L+  +T++E+ G++ I     N  +  
Sbjct: 55  FNNCEVVLGNLEITYVQRNYD------------LSFLKTIQEVAGYVLIAL---NTVERI 99

Query: 416 VFSNLVTIGGRVLYSG------LSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY 469
              NL  I G + Y        LS     + G+  L  ++L+EI  G +  ++N  LC  
Sbjct: 100 PLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV 159

Query: 470 HTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG 529
            +I W  + S+     +   +   +N       C+  C +  CWG G + C    +    
Sbjct: 160 ESIQWRDIVSS---DFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKI--- 213

Query: 530 RICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKD---- 585
            IC + C+   G  R  ++ S C  C  QC         C GP   +C  C  F+D    
Sbjct: 214 -ICAQQCS---GRCRG-KSPSDC--CHNQCAA------GCTGPRESDCLVCRKFRDEATC 260

Query: 586 ---------------------------GPNCVEKCPDGLQ-----------GANSFIFKY 607
                                      G  CV+KCP               GA+S+  + 
Sbjct: 261 KDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEME- 319

Query: 608 ADPDRECHPCHPNCTQGCNG 627
            D  R+C  C   C + CNG
Sbjct: 320 EDGVRKCKKCEGPCRKVCNG 339


>gi|41327734 epidermal growth factor receptor isoform c precursor
           [Homo sapiens]
          Length = 405

 Score =  390 bits (1003), Expect = e-108
 Identities = 179/380 (47%), Positives = 250/380 (65%), Gaps = 5/380 (1%)

Query: 24  DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
           + + VC GT NKL+ L   E  + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 26  EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85

Query: 84  TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
            GYVL+ALN    +PLENL+IIRG   YE+ YALA+  NY  D N  GL+EL ++NL EI
Sbjct: 86  AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143

Query: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
           L+G V    N  LC  ++I W+DIV + + SN+++   N    C +C  SC  G CWG  
Sbjct: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203

Query: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
           E +CQ LT+ +CA+QC GRC G   SDCCH +CA GC+GP+++DC  C  F D   C   
Sbjct: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263

Query: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
           CP   +YNPTT+Q++ N   KY++GA CVKKCP N+VV D  SCVRAC +   E+EE+G+
Sbjct: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323

Query: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
           + CK C   C K C+GIG G    + +++++NI  F NCT I+G+L  L     GD +  
Sbjct: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383

Query: 381 IEAIDPEKLNVFRTVREITG 400
              +DP++L++ +TV+EITG
Sbjct: 384 TPPLDPQELDILKTVKEITG 403



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 59/245 (24%), Positives = 96/245 (39%), Gaps = 40/245 (16%)

Query: 356 FINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFS 415
           F NC  + GNL       + D            L+  +T++E+ G++ I     N  +  
Sbjct: 55  FNNCEVVLGNLEITYVQRNYD------------LSFLKTIQEVAGYVLIAL---NTVERI 99

Query: 416 VFSNLVTIGGRVLYSG------LSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY 469
              NL  I G + Y        LS     + G+  L  ++L+EI  G +  ++N  LC  
Sbjct: 100 PLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV 159

Query: 470 HTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG 529
            +I W  +   ++   +   +   +N       C+  C +  CWG G + C    +    
Sbjct: 160 ESIQWRDI---VSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKI--- 213

Query: 530 RICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNC 589
            IC + C+   G  R  ++ S C  C  QC         C GP   +C  C  F+D   C
Sbjct: 214 -ICAQQCS---GRCRG-KSPSDC--CHNQC------AAGCTGPRESDCLVCRKFRDEATC 260

Query: 590 VEKCP 594
            + CP
Sbjct: 261 KDTCP 265


>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
          Length = 976

 Score =  226 bits (577), Expect = 8e-59
 Identities = 132/366 (36%), Positives = 202/366 (55%), Gaps = 15/366 (4%)

Query: 652  LIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRR--FLETELVEPLTP-----SGTA 704
            +I    +G + +LV+ G+ F ++ RRK+ + +++     F ++E ++PL       +   
Sbjct: 537  VIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYED 596

Query: 705  PNQAQLRILKETE---LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKA 761
            PNQA L+   E     + R KV+G+G FG VYKG+        ++PVAIK L      K 
Sbjct: 597  PNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQ 656

Query: 762  NVEFMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLL 820
             V+F+ EA IM    H +++RL GV      + ++T+ M +G L +++ E         L
Sbjct: 657  RVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQL 716

Query: 821  LNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGD-EKEYNADG 879
            +     IA GM YL     VHRDLAARN+LV S    K++DFGL+R+LE D E  Y   G
Sbjct: 717  VGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSG 776

Query: 880  GKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERL 939
            GK+PI+W A E I YRKFT  SDVWS+G+ +WE+MT+G +PY  +   E+   +  G RL
Sbjct: 777  GKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRL 836

Query: 940  PQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDD---RMKLP 996
            P P  C   +Y +M++CW  +   RPKF ++ +   ++ R P     +   D    ++LP
Sbjct: 837  PTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLP 896

Query: 997  SPNDSK 1002
            S + S+
Sbjct: 897  STSGSE 902


>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
          Length = 1074

 Score =  220 bits (561), Expect = 6e-57
 Identities = 114/295 (38%), Positives = 173/295 (58%), Gaps = 7/295 (2%)

Query: 703 TAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKAN 762
           T P+     I +E  ++  + +G G FG V++GI++   E   + VAIK     T     
Sbjct: 430 TMPSTRDYEIQRE-RIELGRCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVR 487

Query: 763 VEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN 822
            +F+ EAL M   DHPH+V+L+GV     + ++ +L   G L  ++   K ++    L+ 
Sbjct: 488 EKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLIL 547

Query: 823 WCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKM 882
           +  Q++  + YLE +R VHRD+AARNVLV S + VK+ DFGL+R +E D   Y A  GK+
Sbjct: 548 YAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKL 606

Query: 883 PIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 942
           PIKWMA E I++R+FT  SDVW +GV +WE++  G KP+ G+   ++   +E GERLP P
Sbjct: 607 PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 666

Query: 943 PICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPS 997
           P C   +Y +M KCW  D   RP+F EL A+ S +  + +     Q ++RM++ S
Sbjct: 667 PNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK----AQQEERMRMES 717


>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
          Length = 1052

 Score =  220 bits (561), Expect = 6e-57
 Identities = 114/295 (38%), Positives = 173/295 (58%), Gaps = 7/295 (2%)

Query: 703 TAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKAN 762
           T P+     I +E  ++  + +G G FG V++GI++   E   + VAIK     T     
Sbjct: 408 TMPSTRDYEIQRE-RIELGRCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVR 465

Query: 763 VEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN 822
            +F+ EAL M   DHPH+V+L+GV     + ++ +L   G L  ++   K ++    L+ 
Sbjct: 466 EKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLIL 525

Query: 823 WCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKM 882
           +  Q++  + YLE +R VHRD+AARNVLV S + VK+ DFGL+R +E D   Y A  GK+
Sbjct: 526 YAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKL 584

Query: 883 PIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 942
           PIKWMA E I++R+FT  SDVW +GV +WE++  G KP+ G+   ++   +E GERLP P
Sbjct: 585 PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 644

Query: 943 PICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPS 997
           P C   +Y +M KCW  D   RP+F EL A+ S +  + +     Q ++RM++ S
Sbjct: 645 PNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK----AQQEERMRMES 695


>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
            sapiens]
          Length = 1009

 Score =  214 bits (546), Expect = 3e-55
 Identities = 125/376 (33%), Positives = 203/376 (53%), Gaps = 40/376 (10%)

Query: 722  KVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
            ++LG G FG VY+G++   +GE  KI VA+K   +        +FM EA+IM ++DHPH+
Sbjct: 429  RILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486

Query: 781  VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
            V+L+G+       ++ +L P+G L  Y+  +K+++    L+ + +QI K M YLE    V
Sbjct: 487  VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546

Query: 841  HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
            HRD+A RN+LV SP  VK+ DFGL+R +E DE  Y A   ++PIKWM+ E I++R+FT  
Sbjct: 547  HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTA 605

Query: 901  SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
            SDVW + V +WE+++FG +P+  +  +++  +LEKG+RLP+P +C   +Y +M +CW  D
Sbjct: 606  SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665

Query: 961  ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
               RP+F EL    S +                        +  +++  E++        
Sbjct: 666  PSDRPRFTELVCSLSDV-----------------------YQMEKDIAMEQERNARYRTP 702

Query: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGN-QFVYRDGGFAAEQGVSV 1079
            + L P AF  PPP            S   + PPP    ++   QF   +G  A+   ++ 
Sbjct: 703  KILEPTAFQEPPP----------KPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTS 752

Query: 1080 P--YRAPTSTIPEAPV 1093
            P  Y +P +++   P+
Sbjct: 753  PMEYPSPVNSLHTPPL 768


>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
            sapiens]
          Length = 1009

 Score =  214 bits (546), Expect = 3e-55
 Identities = 125/376 (33%), Positives = 203/376 (53%), Gaps = 40/376 (10%)

Query: 722  KVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
            ++LG G FG VY+G++   +GE  KI VA+K   +        +FM EA+IM ++DHPH+
Sbjct: 429  RILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486

Query: 781  VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
            V+L+G+       ++ +L P+G L  Y+  +K+++    L+ + +QI K M YLE    V
Sbjct: 487  VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546

Query: 841  HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
            HRD+A RN+LV SP  VK+ DFGL+R +E DE  Y A   ++PIKWM+ E I++R+FT  
Sbjct: 547  HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTA 605

Query: 901  SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
            SDVW + V +WE+++FG +P+  +  +++  +LEKG+RLP+P +C   +Y +M +CW  D
Sbjct: 606  SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665

Query: 961  ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
               RP+F EL    S +                        +  +++  E++        
Sbjct: 666  PSDRPRFTELVCSLSDV-----------------------YQMEKDIAMEQERNARYRTP 702

Query: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGN-QFVYRDGGFAAEQGVSV 1079
            + L P AF  PPP            S   + PPP    ++   QF   +G  A+   ++ 
Sbjct: 703  KILEPTAFQEPPP----------KPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTS 752

Query: 1080 P--YRAPTSTIPEAPV 1093
            P  Y +P +++   P+
Sbjct: 753  PMEYPSPVNSLHTPPL 768


>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
            sapiens]
          Length = 1009

 Score =  214 bits (546), Expect = 3e-55
 Identities = 125/376 (33%), Positives = 203/376 (53%), Gaps = 40/376 (10%)

Query: 722  KVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
            ++LG G FG VY+G++   +GE  KI VA+K   +        +FM EA+IM ++DHPH+
Sbjct: 429  RILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486

Query: 781  VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
            V+L+G+       ++ +L P+G L  Y+  +K+++    L+ + +QI K M YLE    V
Sbjct: 487  VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546

Query: 841  HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
            HRD+A RN+LV SP  VK+ DFGL+R +E DE  Y A   ++PIKWM+ E I++R+FT  
Sbjct: 547  HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTA 605

Query: 901  SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
            SDVW + V +WE+++FG +P+  +  +++  +LEKG+RLP+P +C   +Y +M +CW  D
Sbjct: 606  SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665

Query: 961  ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 1020
               RP+F EL    S +                        +  +++  E++        
Sbjct: 666  PSDRPRFTELVCSLSDV-----------------------YQMEKDIAMEQERNARYRTP 702

Query: 1021 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGN-QFVYRDGGFAAEQGVSV 1079
            + L P AF  PPP            S   + PPP    ++   QF   +G  A+   ++ 
Sbjct: 703  KILEPTAFQEPPP----------KPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTS 752

Query: 1080 P--YRAPTSTIPEAPV 1093
            P  Y +P +++   P+
Sbjct: 753  PMEYPSPVNSLHTPPL 768


>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
           sapiens]
          Length = 967

 Score =  213 bits (543), Expect = 7e-55
 Identities = 105/255 (41%), Positives = 163/255 (63%), Gaps = 4/255 (1%)

Query: 722 KVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 780
           ++LG G FG VY+G++   +GE  KI VA+K   +        +FM EA+IM ++DHPH+
Sbjct: 429 RILGEGFFGEVYEGVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 486

Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
           V+L+G+       ++ +L P+G L  Y+  +K+++    L+ + +QI K M YLE    V
Sbjct: 487 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 546

Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 900
           HRD+A RN+LV SP  VK+ DFGL+R +E DE  Y A   ++PIKWM+ E I++R+FT  
Sbjct: 547 HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTA 605

Query: 901 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 960
           SDVW + V +WE+++FG +P+  +  +++  +LEKG+RLP+P +C   +Y +M +CW  D
Sbjct: 606 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 665

Query: 961 ADSRPKFKELAAEFS 975
              RP+F EL    S
Sbjct: 666 PSDRPRFTELVCSLS 680


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  213 bits (542), Expect = 1e-54
 Identities = 115/270 (42%), Positives = 161/270 (59%), Gaps = 9/270 (3%)

Query: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
           ++ T++     LG G +G VY G+W    +   + VA+K L E T      EF+ EA +M
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEVE--EFLKEAAVM 321

Query: 773 ASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNIGSQLLLNWCVQIAKG 830
             + HP+LV+LLGVC L P   +VT+ MP+G LL+Y+ E +++ + + +LL    QI+  
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381

Query: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 890
           M YLE++  +HRDLAARN LV   + VK+ DFGL+RL+ GD    +A G K PIKW A E
Sbjct: 382 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 440

Query: 891 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 950
            + Y  F+ +SDVW++GV +WE+ T+G  PY GI   ++ DLLEKG R+ QP  C   VY
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500

Query: 951 MVMVKCWMIDADSRPKFKELAAEFSRMARD 980
            +M  CW      RP F E    F  M  D
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHD 530


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  213 bits (542), Expect = 1e-54
 Identities = 115/270 (42%), Positives = 161/270 (59%), Gaps = 9/270 (3%)

Query: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
           ++ T++     LG G +G VY G+W    +   + VA+K L E T      EF+ EA +M
Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEVE--EFLKEAAVM 336

Query: 773 ASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNIGSQLLLNWCVQIAKG 830
             + HP+LV+LLGVC L P   +VT+ MP+G LL+Y+ E +++ + + +LL    QI+  
Sbjct: 337 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 396

Query: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 890
           M YLE++  +HRDLAARN LV   + VK+ DFGL+RL+ GD    +A G K PIKW A E
Sbjct: 397 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 455

Query: 891 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 950
            + Y  F+ +SDVW++GV +WE+ T+G  PY GI   ++ DLLEKG R+ QP  C   VY
Sbjct: 456 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 515

Query: 951 MVMVKCWMIDADSRPKFKELAAEFSRMARD 980
            +M  CW      RP F E    F  M  D
Sbjct: 516 ELMRACWKWSPADRPSFAETHQAFETMFHD 545


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  213 bits (542), Expect = 1e-54
 Identities = 115/270 (42%), Positives = 161/270 (59%), Gaps = 9/270 (3%)

Query: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
           ++ T++     LG G +G VY G+W    +   + VA+K L E T      EF+ EA +M
Sbjct: 262 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEVE--EFLKEAAVM 315

Query: 773 ASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNIGSQLLLNWCVQIAKG 830
             + HP+LV+LLGVC L P   +VT+ MP+G LL+Y+ E +++ + + +LL    QI+  
Sbjct: 316 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 375

Query: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 890
           M YLE++  +HRDLAARN LV   + VK+ DFGL+RL+ GD    +A G K PIKW A E
Sbjct: 376 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 434

Query: 891 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 950
            + Y  F+ +SDVW++GV +WE+ T+G  PY GI   ++ DLLEKG R+ QP  C   VY
Sbjct: 435 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 494

Query: 951 MVMVKCWMIDADSRPKFKELAAEFSRMARD 980
            +M  CW      RP F E    F  M  D
Sbjct: 495 ELMRACWKWSPADRPSFAETHQAFETMFHD 524


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  213 bits (542), Expect = 1e-54
 Identities = 115/270 (42%), Positives = 161/270 (59%), Gaps = 9/270 (3%)

Query: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
           ++ T++     LG G +G VY G+W    +   + VA+K L E T      EF+ EA +M
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEVE--EFLKEAAVM 321

Query: 773 ASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNIGSQLLLNWCVQIAKG 830
             + HP+LV+LLGVC L P   +VT+ MP+G LL+Y+ E +++ + + +LL    QI+  
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381

Query: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 890
           M YLE++  +HRDLAARN LV   + VK+ DFGL+RL+ GD    +A G K PIKW A E
Sbjct: 382 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 440

Query: 891 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 950
            + Y  F+ +SDVW++GV +WE+ T+G  PY GI   ++ DLLEKG R+ QP  C   VY
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500

Query: 951 MVMVKCWMIDADSRPKFKELAAEFSRMARD 980
            +M  CW      RP F E    F  M  D
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHD 530


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  213 bits (542), Expect = 1e-54
 Identities = 115/270 (42%), Positives = 161/270 (59%), Gaps = 9/270 (3%)

Query: 713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 772
           ++ T++     LG G +G VY G+W    +   + VA+K L E T      EF+ EA +M
Sbjct: 247 MERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDTMEVE--EFLKEAAVM 300

Query: 773 ASMDHPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHE-HKDNIGSQLLLNWCVQIAKG 830
             + HP+LV+LLGVC L P   +VT+ MP+G LL+Y+ E +++ + + +LL    QI+  
Sbjct: 301 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 360

Query: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 890
           M YLE++  +HRDLAARN LV   + VK+ DFGL+RL+ GD    +A G K PIKW A E
Sbjct: 361 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA-GAKFPIKWTAPE 419

Query: 891 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 950
            + Y  F+ +SDVW++GV +WE+ T+G  PY GI   ++ DLLEKG R+ QP  C   VY
Sbjct: 420 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 479

Query: 951 MVMVKCWMIDADSRPKFKELAAEFSRMARD 980
            +M  CW      RP F E    F  M  D
Sbjct: 480 ELMRACWKWSPADRPSFAETHQAFETMFHD 509


>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
           sapiens]
          Length = 1038

 Score =  211 bits (537), Expect = 4e-54
 Identities = 112/277 (40%), Positives = 171/277 (61%), Gaps = 3/277 (1%)

Query: 697 PLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIW-VPEGETVKIPVAIKILNE 755
           P  P+G  P Q+   ++ E +L+ ++ LG G+FG V +G W  P G+TV + V     + 
Sbjct: 105 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDV 164

Query: 756 TTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNI 815
            + P+A  +F+ E   M S+DH +L+RL GV L+P +++VT+L P G LL+ + +H+ + 
Sbjct: 165 LSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHF 224

Query: 816 GSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL-EGDEKE 874
               L  + VQ+A+GM YLE +R +HRDLAARN+L+ + + VKI DFGL R L + D+  
Sbjct: 225 LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHY 284

Query: 875 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE 934
              +  K+P  W A E +  R F+H SD W +GVT+WE+ T+G +P+ G+   +I   ++
Sbjct: 285 VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKID 344

Query: 935 K-GERLPQPPICTIDVYMVMVKCWMIDADSRPKFKEL 970
           K GERLP+P  C  D+Y VMV+CW    + RP F  L
Sbjct: 345 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 381


>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
           sapiens]
          Length = 1086

 Score =  211 bits (537), Expect = 4e-54
 Identities = 112/277 (40%), Positives = 171/277 (61%), Gaps = 3/277 (1%)

Query: 697 PLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIW-VPEGETVKIPVAIKILNE 755
           P  P+G  P Q+   ++ E +L+ ++ LG G+FG V +G W  P G+TV + V     + 
Sbjct: 168 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDV 227

Query: 756 TTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNI 815
            + P+A  +F+ E   M S+DH +L+RL GV L+P +++VT+L P G LL+ + +H+ + 
Sbjct: 228 LSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHF 287

Query: 816 GSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL-EGDEKE 874
               L  + VQ+A+GM YLE +R +HRDLAARN+L+ + + VKI DFGL R L + D+  
Sbjct: 288 LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHY 347

Query: 875 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE 934
              +  K+P  W A E +  R F+H SD W +GVT+WE+ T+G +P+ G+   +I   ++
Sbjct: 348 VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKID 407

Query: 935 K-GERLPQPPICTIDVYMVMVKCWMIDADSRPKFKEL 970
           K GERLP+P  C  D+Y VMV+CW    + RP F  L
Sbjct: 408 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 444


>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
          Length = 984

 Score =  211 bits (536), Expect = 5e-54
 Identities = 127/349 (36%), Positives = 190/349 (54%), Gaps = 21/349 (6%)

Query: 651 PLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETE-----------LVEPLT 699
           PLIA     G+  +V +     V  R+++  K+      L+              ++P T
Sbjct: 540 PLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFT 599

Query: 700 PSGTAPNQAQLRILKETELKRVK---VLGSGAFGTVYKGIWVPEGETVKIPVAIKILNET 756
                PN+A     KE ++  VK   V+G+G FG VYKG     G+  +I VAIK L   
Sbjct: 600 YED--PNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKR-EIYVAIKTLKAG 656

Query: 757 TGPKANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHEHKDNI 815
              K   +F+ EA IM   DHP+++RL GV   S  + ++T+ M +G L  ++ ++    
Sbjct: 657 YSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQF 716

Query: 816 GSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE- 874
               L+     IA GM YL E   VHRDLAARN+LV S    K++DFGL+R L+ D  + 
Sbjct: 717 TVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDP 776

Query: 875 -YNAD-GGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDL 932
            Y +  GGK+P++W A E I YRKFT  SDVWSYG+ +WE+M+FG +PY  +  +++ + 
Sbjct: 777 TYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINA 836

Query: 933 LEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDP 981
           +E+  RLP P  C   ++ +M+ CW  D +SRP+F E+     +M R+P
Sbjct: 837 IEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNP 885


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  209 bits (532), Expect = 1e-53
 Identities = 113/284 (39%), Positives = 168/284 (59%), Gaps = 10/284 (3%)

Query: 699 TPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTG 758
           T  G +PN  +   ++ T++     LG G +G VY+G+W    +   + VA+K L E T 
Sbjct: 224 TVYGVSPNYDKWE-MERTDITMKHKLGGGQYGEVYEGVW----KKYSLTVAVKTLKEDTM 278

Query: 759 PKANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHE-HKDNIG 816
                EF+ EA +M  + HP+LV+LLGVC   P   ++T+ M +G LL+Y+ E ++  + 
Sbjct: 279 EVE--EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 336

Query: 817 SQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYN 876
           + +LL    QI+  M YLE++  +HRDLAARN LV   + VK+ DFGL+RL+ GD    +
Sbjct: 337 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAH 396

Query: 877 ADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKG 936
           A G K PIKW A E + Y KF+ +SDVW++GV +WE+ T+G  PY GI   ++ +LLEK 
Sbjct: 397 A-GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD 455

Query: 937 ERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARD 980
            R+ +P  C   VY +M  CW  +   RP F E+   F  M ++
Sbjct: 456 YRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQE 499


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  209 bits (532), Expect = 1e-53
 Identities = 113/284 (39%), Positives = 168/284 (59%), Gaps = 10/284 (3%)

Query: 699 TPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTG 758
           T  G +PN  +   ++ T++     LG G +G VY+G+W    +   + VA+K L E T 
Sbjct: 243 TVYGVSPNYDKWE-MERTDITMKHKLGGGQYGEVYEGVW----KKYSLTVAVKTLKEDTM 297

Query: 759 PKANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHE-HKDNIG 816
                EF+ EA +M  + HP+LV+LLGVC   P   ++T+ M +G LL+Y+ E ++  + 
Sbjct: 298 EVE--EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 355

Query: 817 SQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYN 876
           + +LL    QI+  M YLE++  +HRDLAARN LV   + VK+ DFGL+RL+ GD    +
Sbjct: 356 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAH 415

Query: 877 ADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKG 936
           A G K PIKW A E + Y KF+ +SDVW++GV +WE+ T+G  PY GI   ++ +LLEK 
Sbjct: 416 A-GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD 474

Query: 937 ERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARD 980
            R+ +P  C   VY +M  CW  +   RP F E+   F  M ++
Sbjct: 475 YRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQE 518


>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
          Length = 986

 Score =  206 bits (524), Expect = 1e-52
 Identities = 124/346 (35%), Positives = 188/346 (54%), Gaps = 16/346 (4%)

Query: 648 ARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKK-------KRALRRFLETELVEPLTP 700
           A + ++   V G + ++VI+   F +  RR    K       ++ L + + T  V+P T 
Sbjct: 544 ANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRT-YVDPFTY 602

Query: 701 SGTAPNQAQLRILKETE---LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETT 757
               PNQA     KE +   +K  KV+G G FG V  G     G+  +I VAIK L    
Sbjct: 603 ED--PNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKR-EICVAIKTLKAGY 659

Query: 758 GPKANVEFMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIG 816
             K   +F+ EA IM   DHP+++ L GV      + ++T+ M +G L  ++ ++     
Sbjct: 660 TDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFT 719

Query: 817 SQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGD-EKEY 875
              L+     I  GM YL +   VHRDLAARN+LV S    K++DFG++R+LE D E  Y
Sbjct: 720 VIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY 779

Query: 876 NADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEK 935
              GGK+PI+W A E I YRKFT  SDVWSYG+ +WE+M++G +PY  +  +++   +E+
Sbjct: 780 TTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEE 839

Query: 936 GERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDP 981
           G RLP P  C I ++ +M+ CW  +   RPKF ++     ++ R+P
Sbjct: 840 GYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNP 885


>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
           sapiens]
          Length = 983

 Score =  206 bits (523), Expect = 2e-52
 Identities = 113/289 (39%), Positives = 170/289 (58%), Gaps = 8/289 (2%)

Query: 705 PNQAQLRILKETELKRV---KVLGSGAFGTVYKG-IWVPEGETVKIPVAIKILNETTGPK 760
           P QA     KE +   +   KV+G+G FG V  G + +P  +  +I VAIK L      K
Sbjct: 605 PTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKK--EISVAIKTLKVGYTEK 662

Query: 761 ANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHEHKDNIGSQL 819
              +F+ EA IM   DHP+++RL GV   S  + +VT+ M +G L  ++ +H        
Sbjct: 663 QRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQ 722

Query: 820 LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGD-EKEYNAD 878
           L+     IA GM YL +   VHRDLAARN+L+ S    K++DFGL+R+LE D E  Y   
Sbjct: 723 LVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 782

Query: 879 GGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGER 938
           GGK+PI+W + E I YRKFT  SDVWSYG+ +WE+M++G +PY  +  +++   +++G R
Sbjct: 783 GGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYR 842

Query: 939 LPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVI 987
           LP P  C   +Y +M+ CW  D ++RPKF+++ +   ++ R+P    +I
Sbjct: 843 LPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKII 891



 Score = 31.2 bits (69), Expect = 6.8
 Identities = 19/65 (29%), Positives = 30/65 (46%), Gaps = 6/65 (9%)

Query: 507 CSSDGCWGPGPDQCLSCRRF--SRGRICIESCNLYDGEFREFENGSICVECDPQCEKMED 564
           CS++G W     +C SC      RG +C ++C    G ++  +    C +C P     ED
Sbjct: 244 CSTEGEWLVPIGKC-SCNAGYEERGFMC-QACR--PGFYKALDGNMKCAKCPPHSSTQED 299

Query: 565 GLLTC 569
           G + C
Sbjct: 300 GSMNC 304


>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
          Length = 612

 Score =  205 bits (521), Expect = 3e-52
 Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%)

Query: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 780
           K LGSG FGTV KG +  + + V   VA+KIL NE   P    E + EA +M  +D+P++
Sbjct: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409

Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
           VR++G+C + +  LV ++   G L +Y+ +++ ++  + ++    Q++ GM YLEE   V
Sbjct: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468

Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 899
           HRDLAARNVL+ + ++ KI+DFGL++ L  DE  Y A   GK P+KW A ECI+Y KF+ 
Sbjct: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528

Query: 900 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 959
           +SDVWS+GV +WE  ++G KPY G+   E+  +LEKGER+  P  C  ++Y +M  CW  
Sbjct: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588

Query: 960 DADSRPKF 967
           D ++RP F
Sbjct: 589 DVENRPGF 596


>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
          Length = 635

 Score =  205 bits (521), Expect = 3e-52
 Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%)

Query: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 780
           K LGSG FGTV KG +  + + V   VA+KIL NE   P    E + EA +M  +D+P++
Sbjct: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432

Query: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
           VR++G+C + +  LV ++   G L +Y+ +++ ++  + ++    Q++ GM YLEE   V
Sbjct: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491

Query: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 899
           HRDLAARNVL+ + ++ KI+DFGL++ L  DE  Y A   GK P+KW A ECI+Y KF+ 
Sbjct: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551

Query: 900 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 959
           +SDVWS+GV +WE  ++G KPY G+   E+  +LEKGER+  P  C  ++Y +M  CW  
Sbjct: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611

Query: 960 DADSRPKF 967
           D ++RP F
Sbjct: 612 DVENRPGF 619


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,222,159
Number of Sequences: 37866
Number of extensions: 2917465
Number of successful extensions: 9315
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 563
Number of HSP's successfully gapped in prelim test: 288
Number of HSP's that attempted gapping in prelim test: 6722
Number of HSP's gapped (non-prelim): 1444
length of query: 1308
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1194
effective length of database: 13,930,794
effective search space: 16633368036
effective search space used: 16633368036
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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