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Search of human proteins with 4826894
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826894 phosphodiesterase 1C [Homo sapiens]
(634 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826894 phosphodiesterase 1C [Homo sapiens] 1254 0.0
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 739 0.0
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 739 0.0
gi|4505677 phosphodiesterase 1B [Homo sapiens] 621 e-178
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 239 4e-63
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 239 4e-63
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 234 1e-61
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 234 1e-61
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 234 1e-61
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 234 1e-61
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 231 2e-60
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 231 2e-60
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 231 2e-60
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 231 2e-60
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 229 4e-60
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 229 4e-60
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 229 4e-60
gi|70608155 phosphodiesterase 3A [Homo sapiens] 188 1e-47
gi|40254434 phosphodiesterase 3B [Homo sapiens] 181 2e-45
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 179 5e-45
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 179 5e-45
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 173 4e-43
gi|9506959 phosphodiesterase 7B [Homo sapiens] 171 1e-42
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 169 7e-42
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 169 7e-42
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 169 7e-42
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 169 7e-42
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 169 7e-42
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 159 7e-39
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 146 6e-35
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 1254 bits (3245), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 1 MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD 60
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
Sbjct: 1 MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD 60
Query: 61 LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR 120
LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR
Sbjct: 61 LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR 120
Query: 121 SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS 180
SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS
Sbjct: 121 SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS 180
Query: 181 GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV 240
GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
Sbjct: 181 GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV 240
Query: 241 HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH 300
HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH
Sbjct: 241 HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH 300
Query: 301 HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE 360
HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE
Sbjct: 301 HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE 360
Query: 361 AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS 420
AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS
Sbjct: 361 AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS 420
Query: 421 TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKR 480
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKR
Sbjct: 421 TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKR 480
Query: 481 SGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKAR 540
SGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKAR
Sbjct: 481 SGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKAR 540
Query: 541 LAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGE 600
LAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGE
Sbjct: 541 LAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGE 600
Query: 601 QQQNGDFKDGKNKTDKKDHSNIGNDSKKTDDSQE 634
QQQNGDFKDGKNKTDKKDHSNIGNDSKKTDDSQE
Sbjct: 601 QQQNGDFKDGKNKTDKKDHSNIGNDSKKTDDSQE 634
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 739 bits (1909), Expect = 0.0
Identities = 369/538 (68%), Positives = 446/538 (82%), Gaps = 14/538 (2%)
Query: 1 MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD 60
M S EIEE E+ + KYL EQ EK+W RL+G+ LR LVKQLERG+ +VVD
Sbjct: 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGI---------LRCLVKQLERGDVNVVD 51
Query: 61 LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR 120
LKKN+EYAA+VLE+VYIDETRRLLDTEDELSDIQ+D+VPSEVRDWLASTFTR+MGM ++
Sbjct: 52 LKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKK 111
Query: 121 SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS 180
+EKP+F+SIVHAVQAGIFVERMYR+T +MVGL+YP AVI LKDVDKWSFDVF+LNEAS
Sbjct: 112 PEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEAS 171
Query: 181 GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV 240
G+H+LKF+ YEL TRYDLI+RFKIP+S L++F EALEVGYSK+KNPYHNL+HAADVTQTV
Sbjct: 172 GEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTV 231
Query: 241 HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH 300
HY++ TG+ +WLTELEI A++F+AAIHDYEHTGTTNNFHIQTRSD AILYNDRSVLENH
Sbjct: 232 HYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENH 291
Query: 301 HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE 360
H+SAAYRL+Q +EEMNILINLSKDDWR+ R LVIEMV++TDMS HFQQIK ++ +LQQPE
Sbjct: 292 HVSAAYRLMQ-EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE 350
Query: 361 AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS 420
I++ K +SL+LH ADISHPAK+W LH+RWTM+L+EEFF QGD+EAELGLPFSPLCDRKS
Sbjct: 351 GIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKS 410
Query: 421 TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISS---SD 477
TMVAQSQ+GFIDFIVEPTF++LTD TEKIV PLI+E S+ + SS +I +D
Sbjct: 411 TMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIAD 470
Query: 478 A-KRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKE 534
A +RS K S S+GS + S+ +VD KSFK +++ N+ERW+ +E + +
Sbjct: 471 ALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQ 528
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 739 bits (1908), Expect = 0.0
Identities = 375/554 (67%), Positives = 453/554 (81%), Gaps = 17/554 (3%)
Query: 1 MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD 60
M S EIEE E+ + KYL EQ EK+W RL+G+ LR LVKQLERG+ +VVD
Sbjct: 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGI---------LRCLVKQLERGDVNVVD 51
Query: 61 LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR 120
LKKN+EYAA+VLE+VYIDETRRLLDTEDELSDIQ+D+VPSEVRDWLASTFTR+MGM ++
Sbjct: 52 LKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKK 111
Query: 121 SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS 180
+EKP+F+SIVHAVQAGIFVERMYR+T +MVGL+YP AVI LKDVDKWSFDVF+LNEAS
Sbjct: 112 PEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEAS 171
Query: 181 GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV 240
G+H+LKF+ YEL TRYDLI+RFKIP+S L++F EALEVGYSK+KNPYHNL+HAADVTQTV
Sbjct: 172 GEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTV 231
Query: 241 HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH 300
HY++ TG+ +WLTELEI A++F+AAIHDYEHTGTTNNFHIQTRSD AILYNDRSVLENH
Sbjct: 232 HYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENH 291
Query: 301 HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE 360
H+SAAYRL+Q +EEMNILINLSKDDWR+ R LVIEMV++TDMS HFQQIK ++ +LQQPE
Sbjct: 292 HVSAAYRLMQ-EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE 350
Query: 361 AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS 420
I++ K +SL+LH ADISHPAK+W LH+RWTM+L+EEFF QGD+EAELGLPFSPLCDRKS
Sbjct: 351 GIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKS 410
Query: 421 TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISS---SD 477
TMVAQSQ+GFIDFIVEPTF++LTD TEKIV PLI+E S+ + SS +I +D
Sbjct: 411 TMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIAD 470
Query: 478 A-KRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPK-EEKAKKEA 535
A +RS K S S+GS + S+ +VD KSFK +++ N+ERW+ + E K +
Sbjct: 471 ALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNS 530
Query: 536 EEKARLAAEEQQKE 549
E+ AEE+ E
Sbjct: 531 EDLVN--AEEKHDE 542
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 621 bits (1601), Expect = e-178
Identities = 312/522 (59%), Positives = 400/522 (76%), Gaps = 29/522 (5%)
Query: 3 SPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLK 62
SP + +EE + S L+ +K+W++LR L +Y +VKQLE GE ++ +LK
Sbjct: 7 SPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRY---------MVKQLENGEINIEELK 57
Query: 63 KNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSD 122
KNLEY A++LE+VYIDETR++LDTEDEL +++SDAVPSEVRDWLASTFT+Q RR++
Sbjct: 58 KNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAE 117
Query: 123 EKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGD 182
EKP+F+SIVHAVQAGIFVERM+RRT VG +Y AV+ LK++D W FDVFSLN+A+ D
Sbjct: 118 EKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADD 177
Query: 183 HALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHY 242
HAL+ I +ELLTR++LISRFKIP L+SF++ALE GY K+KNPYHN +HAADVTQTVH
Sbjct: 178 HALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHC 237
Query: 243 LLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHL 302
L +TG+ + L+E+E+ AIIF+AAIHDYEHTGTTN+FHIQT+S+ AI+YNDRSVLENHH+
Sbjct: 238 FLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHI 297
Query: 303 SAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAI 362
S+ +RL+QDD EMNI INL+KD++ E R LVIEMV+ATDMSCHFQQ+K MKTALQQ E I
Sbjct: 298 SSVFRLMQDD-EMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERI 356
Query: 363 EKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTM 422
+KPKALSL+LH ADISHP K W +H RWT +L+EEFFRQGD+EAELGLPFSPLCDR ST+
Sbjct: 357 DKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTL 416
Query: 423 VAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSG 482
VAQSQ+GFIDFIVEPTF+VLTD+ EK V PL DE S++ ++
Sbjct: 417 VAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKS-------------------KNQ 457
Query: 483 VKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAK 524
+ S + + D SF++TW + + N+++W+ +
Sbjct: 458 PSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKER 499
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 239 bits (611), Expect = 4e-63
Identities = 142/415 (34%), Positives = 219/415 (52%), Gaps = 29/415 (6%)
Query: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
L+DV+KW VF + E SG+ L I + + DL+ FKIP+ L++++ LE Y
Sbjct: 398 LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHA 457
Query: 223 HKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQ 282
YHN +HAADV Q+ H LL + T+LEI A IF++AIHD +H G +N F I
Sbjct: 458 DV-AYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 516
Query: 283 TRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDM 342
T S+ A++YND SVLENHHL+ ++LLQ +E +I NL+K + R +VI++V+ATDM
Sbjct: 517 TNSELALMYNDSSVLENHHLAVGFKLLQ-EENCDIFQNLTKKQRQSLRKMVIDIVLATDM 575
Query: 343 SCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHRWT 391
S H + +KT ++ + ++ + L M+H AD+S+P K L+ +WT
Sbjct: 576 SKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWT 635
Query: 392 MSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVS 451
++EEFFRQGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 636 DRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQ 695
Query: 452 PLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWT 511
++D R ++I S + G +G + F+ T
Sbjct: 696 DILDTLED-----NREWYQSTIPQSPSPAPDDPEEGRQG---------QTEKFQFELTLE 741
Query: 512 EVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEK 566
E + E+ +E+ + ++ K + + E+ Q EE A G+ E+
Sbjct: 742 EDGESDTEKDSGSQVEEDTSC--SDSKTLCTQDSESTEIPLDEQVEEEAVGEEEE 794
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 239 bits (611), Expect = 4e-63
Identities = 142/415 (34%), Positives = 219/415 (52%), Gaps = 29/415 (6%)
Query: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
L+DV+KW VF + E SG+ L I + + DL+ FKIP+ L++++ LE Y
Sbjct: 262 LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHA 321
Query: 223 HKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQ 282
YHN +HAADV Q+ H LL + T+LEI A IF++AIHD +H G +N F I
Sbjct: 322 DV-AYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 380
Query: 283 TRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDM 342
T S+ A++YND SVLENHHL+ ++LLQ +E +I NL+K + R +VI++V+ATDM
Sbjct: 381 TNSELALMYNDSSVLENHHLAVGFKLLQ-EENCDIFQNLTKKQRQSLRKMVIDIVLATDM 439
Query: 343 SCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHRWT 391
S H + +KT ++ + ++ + L M+H AD+S+P K L+ +WT
Sbjct: 440 SKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWT 499
Query: 392 MSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVS 451
++EEFFRQGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 500 DRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQ 559
Query: 452 PLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWT 511
++D R ++I S + G +G + F+ T
Sbjct: 560 DILDTLED-----NREWYQSTIPQSPSPAPDDPEEGRQG---------QTEKFQFELTLE 605
Query: 512 EVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEK 566
E + E+ +E+ + ++ K + + E+ Q EE A G+ E+
Sbjct: 606 EDGESDTEKDSGSQVEEDTSC--SDSKTLCTQDSESTEIPLDEQVEEEAVGEEEE 658
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 234 bits (598), Expect = 1e-61
Identities = 119/306 (38%), Positives = 187/306 (61%), Gaps = 13/306 (4%)
Query: 161 EALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGY 220
+ L++++KW ++F +++ +G +L I Y + DL+ +F+IP+ +V+++ LE Y
Sbjct: 306 QELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHY 365
Query: 221 SKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFH 280
YHN +HAADV Q+ H LL + T+LEI A +F+AAIHD +H G +N F
Sbjct: 366 HADV-AYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFL 424
Query: 281 IQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMAT 340
I T S+ A++YND SVLENHHL+ ++LLQ+D +I NLSK + R +VI+MV+AT
Sbjct: 425 INTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVIDMVLAT 483
Query: 341 DMSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHR 389
DMS H + +KT ++ + ++ + L M+H AD+S+P K +L+ +
Sbjct: 484 DMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQ 543
Query: 390 WTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKI 449
WT ++ EFF+QGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 544 WTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD 603
Query: 450 VSPLID 455
++D
Sbjct: 604 AQEILD 609
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 234 bits (598), Expect = 1e-61
Identities = 119/306 (38%), Positives = 187/306 (61%), Gaps = 13/306 (4%)
Query: 161 EALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGY 220
+ L++++KW ++F +++ +G +L I Y + DL+ +F+IP+ +V+++ LE Y
Sbjct: 341 QELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHY 400
Query: 221 SKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFH 280
YHN +HAADV Q+ H LL + T+LEI A +F+AAIHD +H G +N F
Sbjct: 401 HADV-AYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFL 459
Query: 281 IQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMAT 340
I T S+ A++YND SVLENHHL+ ++LLQ+D +I NLSK + R +VI+MV+AT
Sbjct: 460 INTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVIDMVLAT 518
Query: 341 DMSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHR 389
DMS H + +KT ++ + ++ + L M+H AD+S+P K +L+ +
Sbjct: 519 DMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQ 578
Query: 390 WTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKI 449
WT ++ EFF+QGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 579 WTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD 638
Query: 450 VSPLID 455
++D
Sbjct: 639 AQEILD 644
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 234 bits (598), Expect = 1e-61
Identities = 119/306 (38%), Positives = 187/306 (61%), Gaps = 13/306 (4%)
Query: 161 EALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGY 220
+ L++++KW ++F +++ +G +L I Y + DL+ +F+IP+ +V+++ LE Y
Sbjct: 367 QELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHY 426
Query: 221 SKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFH 280
YHN +HAADV Q+ H LL + T+LEI A +F+AAIHD +H G +N F
Sbjct: 427 HADV-AYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFL 485
Query: 281 IQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMAT 340
I T S+ A++YND SVLENHHL+ ++LLQ+D +I NLSK + R +VI+MV+AT
Sbjct: 486 INTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVIDMVLAT 544
Query: 341 DMSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHR 389
DMS H + +KT ++ + ++ + L M+H AD+S+P K +L+ +
Sbjct: 545 DMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQ 604
Query: 390 WTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKI 449
WT ++ EFF+QGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 605 WTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD 664
Query: 450 VSPLID 455
++D
Sbjct: 665 AQEILD 670
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 234 bits (598), Expect = 1e-61
Identities = 119/306 (38%), Positives = 187/306 (61%), Gaps = 13/306 (4%)
Query: 161 EALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGY 220
+ L++++KW ++F +++ +G +L I Y + DL+ +F+IP+ +V+++ LE Y
Sbjct: 128 QELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHY 187
Query: 221 SKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFH 280
YHN +HAADV Q+ H LL + T+LEI A +F+AAIHD +H G +N F
Sbjct: 188 HADV-AYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFL 246
Query: 281 IQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMAT 340
I T S+ A++YND SVLENHHL+ ++LLQ+D +I NLSK + R +VI+MV+AT
Sbjct: 247 INTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVIDMVLAT 305
Query: 341 DMSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHR 389
DMS H + +KT ++ + ++ + L M+H AD+S+P K +L+ +
Sbjct: 306 DMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQ 365
Query: 390 WTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKI 449
WT ++ EFF+QGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 366 WTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD 425
Query: 450 VSPLID 455
++D
Sbjct: 426 AQEILD 431
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 231 bits (588), Expect = 2e-60
Identities = 133/397 (33%), Positives = 222/397 (55%), Gaps = 26/397 (6%)
Query: 81 RRLLDTE-DELSDIQSDAVPSEVRDWLASTFT-RQMGMMLRRSDEKPRFKSIVHAVQAGI 138
+R+L+ E LS++ ++V +++++TF +Q + + +K R K + I
Sbjct: 251 KRMLNRELTHLSEMSRSG--NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQI 308
Query: 139 FVERMYRRTSNM---------VGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIF 189
+ +S++ V + + L+D++KW ++F++ S + L I
Sbjct: 309 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 368
Query: 190 YELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGV 249
Y + DL+ F+I ++++ LE Y YHN +HAADV Q+ H LL +
Sbjct: 369 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV-AYHNSLHAADVAQSTHVLLSTPAL 427
Query: 250 ANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLL 309
T+LEI A IF+AAIHD +H G +N F I T S+ A++YND SVLENHHL+ ++LL
Sbjct: 428 DAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLL 487
Query: 310 QDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------- 361
Q +E +I +NL+K + R +VI+MV+ATDMS H + +KT ++ +
Sbjct: 488 Q-EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLL 546
Query: 362 ---IEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR 418
++ + L M+H AD+S+P K+ +L+ +WT ++EEFF+QGD+E E G+ SP+CD+
Sbjct: 547 DNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDK 606
Query: 419 KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLID 455
+ V +SQVGFID+IV P + D+ + ++D
Sbjct: 607 HTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD 643
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 231 bits (588), Expect = 2e-60
Identities = 133/397 (33%), Positives = 222/397 (55%), Gaps = 26/397 (6%)
Query: 81 RRLLDTE-DELSDIQSDAVPSEVRDWLASTFT-RQMGMMLRRSDEKPRFKSIVHAVQAGI 138
+R+L+ E LS++ ++V +++++TF +Q + + +K R K + I
Sbjct: 236 KRMLNRELTHLSEMSRSG--NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQI 293
Query: 139 FVERMYRRTSNM---------VGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIF 189
+ +S++ V + + L+D++KW ++F++ S + L I
Sbjct: 294 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 353
Query: 190 YELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGV 249
Y + DL+ F+I ++++ LE Y YHN +HAADV Q+ H LL +
Sbjct: 354 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV-AYHNSLHAADVAQSTHVLLSTPAL 412
Query: 250 ANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLL 309
T+LEI A IF+AAIHD +H G +N F I T S+ A++YND SVLENHHL+ ++LL
Sbjct: 413 DAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLL 472
Query: 310 QDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------- 361
Q +E +I +NL+K + R +VI+MV+ATDMS H + +KT ++ +
Sbjct: 473 Q-EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLL 531
Query: 362 ---IEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR 418
++ + L M+H AD+S+P K+ +L+ +WT ++EEFF+QGD+E E G+ SP+CD+
Sbjct: 532 DNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDK 591
Query: 419 KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLID 455
+ V +SQVGFID+IV P + D+ + ++D
Sbjct: 592 HTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD 628
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 231 bits (588), Expect = 2e-60
Identities = 133/397 (33%), Positives = 222/397 (55%), Gaps = 26/397 (6%)
Query: 81 RRLLDTE-DELSDIQSDAVPSEVRDWLASTFT-RQMGMMLRRSDEKPRFKSIVHAVQAGI 138
+R+L+ E LS++ ++V +++++TF +Q + + +K R K + I
Sbjct: 79 KRMLNRELTHLSEMSRSG--NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQI 136
Query: 139 FVERMYRRTSNM---------VGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIF 189
+ +S++ V + + L+D++KW ++F++ S + L I
Sbjct: 137 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 196
Query: 190 YELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGV 249
Y + DL+ F+I ++++ LE Y YHN +HAADV Q+ H LL +
Sbjct: 197 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV-AYHNSLHAADVAQSTHVLLSTPAL 255
Query: 250 ANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLL 309
T+LEI A IF+AAIHD +H G +N F I T S+ A++YND SVLENHHL+ ++LL
Sbjct: 256 DAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLL 315
Query: 310 QDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------- 361
Q +E +I +NL+K + R +VI+MV+ATDMS H + +KT ++ +
Sbjct: 316 Q-EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLL 374
Query: 362 ---IEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR 418
++ + L M+H AD+S+P K+ +L+ +WT ++EEFF+QGD+E E G+ SP+CD+
Sbjct: 375 DNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDK 434
Query: 419 KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLID 455
+ V +SQVGFID+IV P + D+ + ++D
Sbjct: 435 HTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD 471
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 231 bits (588), Expect = 2e-60
Identities = 133/397 (33%), Positives = 222/397 (55%), Gaps = 26/397 (6%)
Query: 81 RRLLDTE-DELSDIQSDAVPSEVRDWLASTFT-RQMGMMLRRSDEKPRFKSIVHAVQAGI 138
+R+L+ E LS++ ++V +++++TF +Q + + +K R K + I
Sbjct: 251 KRMLNRELTHLSEMSRSG--NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQI 308
Query: 139 FVERMYRRTSNM---------VGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIF 189
+ +S++ V + + L+D++KW ++F++ S + L I
Sbjct: 309 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 368
Query: 190 YELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGV 249
Y + DL+ F+I ++++ LE Y YHN +HAADV Q+ H LL +
Sbjct: 369 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV-AYHNSLHAADVAQSTHVLLSTPAL 427
Query: 250 ANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLL 309
T+LEI A IF+AAIHD +H G +N F I T S+ A++YND SVLENHHL+ ++LL
Sbjct: 428 DAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLL 487
Query: 310 QDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------- 361
Q +E +I +NL+K + R +VI+MV+ATDMS H + +KT ++ +
Sbjct: 488 Q-EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLL 546
Query: 362 ---IEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR 418
++ + L M+H AD+S+P K+ +L+ +WT ++EEFF+QGD+E E G+ SP+CD+
Sbjct: 547 DNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDK 606
Query: 419 KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLID 455
+ V +SQVGFID+IV P + D+ + ++D
Sbjct: 607 HTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD 643
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 229 bits (585), Expect = 4e-60
Identities = 123/305 (40%), Positives = 178/305 (58%), Gaps = 15/305 (4%)
Query: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
L+D +KW DVF + E SG+ L I + + DL+ F+IP L +++ LE Y
Sbjct: 218 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY-- 275
Query: 223 HKN-PYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHI 281
H N YHN +HAADV Q+ H LL + T+LEI A +F++AIHD +H G +N F I
Sbjct: 276 HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI 335
Query: 282 QTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATD 341
T S+ A++YND SVLENHHL+ ++LLQ E +I NLS R +VI+MV+ATD
Sbjct: 336 NTNSELALMYNDASVLENHHLAVGFKLLQ-AENCDIFQNLSAKQRLSLRRMVIDMVLATD 394
Query: 342 MSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHRW 390
MS H + +KT ++ + ++ + L ++H AD+S+P K L+ +W
Sbjct: 395 MSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQW 454
Query: 391 TMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIV 450
T ++ EFF+QGDRE E GL SP+CD+ + V +SQVGFID+I P + D+
Sbjct: 455 TDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDA 514
Query: 451 SPLID 455
L+D
Sbjct: 515 QDLLD 519
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 229 bits (585), Expect = 4e-60
Identities = 123/305 (40%), Positives = 178/305 (58%), Gaps = 15/305 (4%)
Query: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
L+D +KW DVF + E SG+ L I + + DL+ F+IP L +++ LE Y
Sbjct: 292 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY-- 349
Query: 223 HKN-PYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHI 281
H N YHN +HAADV Q+ H LL + T+LEI A +F++AIHD +H G +N F I
Sbjct: 350 HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI 409
Query: 282 QTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATD 341
T S+ A++YND SVLENHHL+ ++LLQ E +I NLS R +VI+MV+ATD
Sbjct: 410 NTNSELALMYNDASVLENHHLAVGFKLLQ-AENCDIFQNLSAKQRLSLRRMVIDMVLATD 468
Query: 342 MSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHRW 390
MS H + +KT ++ + ++ + L ++H AD+S+P K L+ +W
Sbjct: 469 MSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQW 528
Query: 391 TMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIV 450
T ++ EFF+QGDRE E GL SP+CD+ + V +SQVGFID+I P + D+
Sbjct: 529 TDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDA 588
Query: 451 SPLID 455
L+D
Sbjct: 589 QDLLD 593
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 229 bits (585), Expect = 4e-60
Identities = 123/305 (40%), Positives = 178/305 (58%), Gaps = 15/305 (4%)
Query: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
L+D +KW DVF + E SG+ L I + + DL+ F+IP L +++ LE Y
Sbjct: 324 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY-- 381
Query: 223 HKN-PYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHI 281
H N YHN +HAADV Q+ H LL + T+LEI A +F++AIHD +H G +N F I
Sbjct: 382 HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI 441
Query: 282 QTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATD 341
T S+ A++YND SVLENHHL+ ++LLQ E +I NLS R +VI+MV+ATD
Sbjct: 442 NTNSELALMYNDASVLENHHLAVGFKLLQ-AENCDIFQNLSAKQRLSLRRMVIDMVLATD 500
Query: 342 MSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHRW 390
MS H + +KT ++ + ++ + L ++H AD+S+P K L+ +W
Sbjct: 501 MSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQW 560
Query: 391 TMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIV 450
T ++ EFF+QGDRE E GL SP+CD+ + V +SQVGFID+I P + D+
Sbjct: 561 TDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDA 620
Query: 451 SPLID 455
L+D
Sbjct: 621 QDLLD 625
>gi|70608155 phosphodiesterase 3A [Homo sapiens]
Length = 1141
Score = 188 bits (477), Expect = 1e-47
Identities = 136/470 (28%), Positives = 206/470 (43%), Gaps = 80/470 (17%)
Query: 163 LKDVDKWSFDVFSLNEASG---DHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVG 219
++ ++ W+F +F L E G L + Y L L FKIPI +++ ALE+G
Sbjct: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
Query: 220 YSKHKNPYHNLMHAADVTQTVHYLLYKT--GVANWLTE---------------------- 255
Y PYHN +HA DV V YL + G++ + +
Sbjct: 746 Y--RDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVF 803
Query: 256 --------------------LEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRS 295
LE+ A+ +AA+HDY+H G TN F + T + A+LYNDRS
Sbjct: 804 SKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRS 863
Query: 296 VLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTA 355
VLENHH +AA+ L E N LINL +++ FR LVIE ++ATD+ HF +
Sbjct: 864 VLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGK 923
Query: 356 LQQPEAI------EKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELG 409
+ I ++ + + ADI+ PAK +LH +WT ++ EF+ QGD EA LG
Sbjct: 924 VNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLG 983
Query: 410 LPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSS 469
LP SP DR + +A Q FI IV P D + ++++ ++G T
Sbjct: 984 LPISPFMDRSAPQLANLQESFISHIVGPLCNSY-DSAGLMPGKWVEDSDESGDT------ 1036
Query: 470 LNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHI--NRERWRAKVPK 527
+ + E + N S +K K H+ N + W
Sbjct: 1037 ----DDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMW------ 1086
Query: 528 EEKAKKEAEEKARLAAEEQQK--EMEAKSQAEEGASGKAEKKTSGETKNQ 575
KK EE+ RLA E Q + +E+ + K E++ G+ + +
Sbjct: 1087 ----KKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGE 1132
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 181 bits (459), Expect = 2e-45
Identities = 131/455 (28%), Positives = 203/455 (44%), Gaps = 74/455 (16%)
Query: 163 LKDVDKWSFDVFSLNEASGDHA---LKFIFYELLTRYDLISRFKIPISALVSFVEALEVG 219
++ + W+F +F L E G+ + L + Y L L+ FKIP +++ ALE G
Sbjct: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
Query: 220 YSKHKNPYHNLMHAADVTQTVHYLLYK-------------TG------------------ 248
Y PYHN +HA DV V YL + TG
Sbjct: 731 Y--RDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Query: 249 -------------VANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRS 295
+++ + LE+ A+ +AA+HDY+H G TN F + T + A+LYNDRS
Sbjct: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
Query: 296 VLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAM--- 352
VLENHH ++A+ L E N L++L +++ FR LVIE ++ATD+ HF +
Sbjct: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
Query: 353 -----KTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAE 407
++ ++ + + ADI+ PAK DLH +WT ++ EF+ QGD EA
Sbjct: 909 ANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEAN 968
Query: 408 LGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRR 467
LGLP SP DR S +A+ Q FI IV P + D G
Sbjct: 969 LGLPISPFMDRSSPQLAKLQESFITHIVGP------------LCNSYDAAGLLPGQWLEA 1016
Query: 468 SSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVH---INRERWRAK 524
N S D G + + N + KS + + +++H N + W+
Sbjct: 1017 EEDNDTESGD-DEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEI 1075
Query: 525 VPKEEKAKKEAEE-KARLAAEEQQKEMEAKSQAEE 558
V +EEK K + + + ++ Q E++ +A+E
Sbjct: 1076 VEEEEKCKADGNKLQVENSSLPQADEIQVIEEADE 1110
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 179 bits (455), Expect = 5e-45
Identities = 96/307 (31%), Positives = 161/307 (52%), Gaps = 24/307 (7%)
Query: 156 PPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEA 215
PP + A+++ + W FD+F L A+ + L ++ ++ R+ + S L S+++
Sbjct: 439 PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQI 498
Query: 216 LEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGT 275
+E Y NPYHN H+ADV Y L K + L ++ A + +A IHD +H G
Sbjct: 499 IEANYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGR 557
Query: 276 TNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIE 335
TN+F S+ AILYND +VLE+HH + A++L D++ NI N+ ++D+R R +I+
Sbjct: 558 TNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIID 617
Query: 336 MVMATDMSCHFQQIKAMKTALQQP--------EAIEKPKALSLMLHT------------- 374
MV+AT+M+ HF+ + ++ +P E + + ++ ML T
Sbjct: 618 MVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIK 677
Query: 375 -ADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLP-FSPLCDRKSTMVAQSQVGFID 432
AD+S+P + W + EE+F Q D E + GLP P+ DR + + +SQ+ FID
Sbjct: 678 CADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFID 737
Query: 433 FIVEPTF 439
+ + F
Sbjct: 738 YFITDMF 744
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 179 bits (455), Expect = 5e-45
Identities = 96/307 (31%), Positives = 161/307 (52%), Gaps = 24/307 (7%)
Query: 156 PPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEA 215
PP + A+++ + W FD+F L A+ + L ++ ++ R+ + S L S+++
Sbjct: 485 PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQI 544
Query: 216 LEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGT 275
+E Y NPYHN H+ADV Y L K + L ++ A + +A IHD +H G
Sbjct: 545 IEANYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGR 603
Query: 276 TNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIE 335
TN+F S+ AILYND +VLE+HH + A++L D++ NI N+ ++D+R R +I+
Sbjct: 604 TNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIID 663
Query: 336 MVMATDMSCHFQQIKAMKTALQQP--------EAIEKPKALSLMLHT------------- 374
MV+AT+M+ HF+ + ++ +P E + + ++ ML T
Sbjct: 664 MVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIK 723
Query: 375 -ADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLP-FSPLCDRKSTMVAQSQVGFID 432
AD+S+P + W + EE+F Q D E + GLP P+ DR + + +SQ+ FID
Sbjct: 724 CADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFID 783
Query: 433 FIVEPTF 439
+ + F
Sbjct: 784 YFITDMF 790
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 173 bits (439), Expect = 4e-43
Identities = 95/283 (33%), Positives = 156/283 (55%), Gaps = 9/283 (3%)
Query: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
L+ V W+FD+F + + ++L + + L + + LI F + + L F+ ++ Y
Sbjct: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
Query: 223 HKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQ 282
+NPYHN +HAADVTQ +H L + +AN +T +I + +AA HD +H G F I+
Sbjct: 182 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
Query: 283 TRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDM 342
T A LY + SVLENHH +A LL+ E + +L + ++ T + +++ATD+
Sbjct: 241 TNHYLATLYKNTSVLENHHWRSAVGLLR---ESGLFSHLPLESRQQMETQIGALILATDI 297
Query: 343 SCHFQQIKAMKTALQQ-----PEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEE 397
S + + ++ L + + + L + L ADI +P + W+L +W+ + EE
Sbjct: 298 SRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEE 357
Query: 398 FFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFT 440
FF QGD E + L SPLCDR + +A Q+GF+ ++VEP FT
Sbjct: 358 FFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFT 400
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 171 bits (434), Expect = 1e-42
Identities = 105/346 (30%), Positives = 177/346 (51%), Gaps = 19/346 (5%)
Query: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
L V W FD+F + + ++L + L + LI FK+ + L F+ ++ Y
Sbjct: 109 LSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHS 168
Query: 223 HKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQ 282
+NPYHN +HAADVTQ +H L + +A++LT L+I + +AA HD +H G F I+
Sbjct: 169 -QNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK 227
Query: 283 TRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDM 342
T A LY + SVLENHH + +L+ E +L +L K+ ++ + +++ATD+
Sbjct: 228 TNHHLANLYQNMSVLENHHWRSTIGMLR---ESRLLAHLPKEMTQDIEQQLGSLILATDI 284
Query: 343 SCHFQQIKAMKTALQQ-----PEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEE 397
+ + + +K L +A ++ L + L ADI +P + W++ +W+ + EE
Sbjct: 285 NRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEE 344
Query: 398 FFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPT------FTVLTDMTEKIVS 451
F+RQG+ E + L SPLC+++ + Q+GF+ +IVEP FT + ++E ++
Sbjct: 345 FYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLG 404
Query: 452 PLIDETSQTGGTGQR----RSSLNSISSSDAKRSGVKTSGSEGSAP 493
L +Q R R S S D G ++ EG +P
Sbjct: 405 HLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP 450
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 169 bits (428), Expect = 7e-42
Identities = 91/303 (30%), Positives = 156/303 (51%), Gaps = 20/303 (6%)
Query: 156 PPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEA 215
PP + + L + + W F++F L + L ++ ++ +R+ + + L ++ +
Sbjct: 497 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 556
Query: 216 LEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGT 275
+E Y N YHN HAADV + L K V L +L+ A + +A +HD +H G
Sbjct: 557 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 615
Query: 276 TNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIE 335
TN+F S+ A+LYND +VLE+HH + A++L D + NI N+ ++ +R R +I+
Sbjct: 616 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 675
Query: 336 MVMATDMSCHFQQIKAMKTALQQPEAIE--------KPKALS----------LMLHTADI 377
MV+AT+M+ HF+ + ++ +P A E P + +M+ AD+
Sbjct: 676 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 735
Query: 378 SHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLP-FSPLCDRKSTMVAQSQVGFIDFIVE 436
++P + DL W + EE+F Q D E GLP P+ DR + + +SQ+ FID+ +
Sbjct: 736 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 795
Query: 437 PTF 439
F
Sbjct: 796 DMF 798
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 169 bits (428), Expect = 7e-42
Identities = 91/303 (30%), Positives = 156/303 (51%), Gaps = 20/303 (6%)
Query: 156 PPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEA 215
PP + + L + + W F++F L + L ++ ++ +R+ + + L ++ +
Sbjct: 524 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 583
Query: 216 LEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGT 275
+E Y N YHN HAADV + L K V L +L+ A + +A +HD +H G
Sbjct: 584 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 642
Query: 276 TNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIE 335
TN+F S+ A+LYND +VLE+HH + A++L D + NI N+ ++ +R R +I+
Sbjct: 643 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 702
Query: 336 MVMATDMSCHFQQIKAMKTALQQPEAIE--------KPKALS----------LMLHTADI 377
MV+AT+M+ HF+ + ++ +P A E P + +M+ AD+
Sbjct: 703 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 762
Query: 378 SHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLP-FSPLCDRKSTMVAQSQVGFIDFIVE 436
++P + DL W + EE+F Q D E GLP P+ DR + + +SQ+ FID+ +
Sbjct: 763 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 822
Query: 437 PTF 439
F
Sbjct: 823 DMF 825
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 169 bits (428), Expect = 7e-42
Identities = 91/303 (30%), Positives = 156/303 (51%), Gaps = 20/303 (6%)
Query: 156 PPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEA 215
PP + + L + + W F++F L + L ++ ++ +R+ + + L ++ +
Sbjct: 489 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 548
Query: 216 LEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGT 275
+E Y N YHN HAADV + L K V L +L+ A + +A +HD +H G
Sbjct: 549 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 607
Query: 276 TNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIE 335
TN+F S+ A+LYND +VLE+HH + A++L D + NI N+ ++ +R R +I+
Sbjct: 608 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 667
Query: 336 MVMATDMSCHFQQIKAMKTALQQPEAIE--------KPKALS----------LMLHTADI 377
MV+AT+M+ HF+ + ++ +P A E P + +M+ AD+
Sbjct: 668 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 727
Query: 378 SHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLP-FSPLCDRKSTMVAQSQVGFIDFIVE 436
++P + DL W + EE+F Q D E GLP P+ DR + + +SQ+ FID+ +
Sbjct: 728 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
Query: 437 PTF 439
F
Sbjct: 788 DMF 790
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 169 bits (428), Expect = 7e-42
Identities = 91/303 (30%), Positives = 156/303 (51%), Gaps = 20/303 (6%)
Query: 156 PPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEA 215
PP + + L + + W F++F L + L ++ ++ +R+ + + L ++ +
Sbjct: 447 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 506
Query: 216 LEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGT 275
+E Y N YHN HAADV + L K V L +L+ A + +A +HD +H G
Sbjct: 507 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 565
Query: 276 TNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIE 335
TN+F S+ A+LYND +VLE+HH + A++L D + NI N+ ++ +R R +I+
Sbjct: 566 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 625
Query: 336 MVMATDMSCHFQQIKAMKTALQQPEAIE--------KPKALS----------LMLHTADI 377
MV+AT+M+ HF+ + ++ +P A E P + +M+ AD+
Sbjct: 626 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 685
Query: 378 SHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLP-FSPLCDRKSTMVAQSQVGFIDFIVE 436
++P + DL W + EE+F Q D E GLP P+ DR + + +SQ+ FID+ +
Sbjct: 686 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 745
Query: 437 PTF 439
F
Sbjct: 746 DMF 748
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 169 bits (428), Expect = 7e-42
Identities = 91/303 (30%), Positives = 156/303 (51%), Gaps = 20/303 (6%)
Query: 156 PPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEA 215
PP + + L + + W F++F L + L ++ ++ +R+ + + L ++ +
Sbjct: 544 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 603
Query: 216 LEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGT 275
+E Y N YHN HAADV + L K V L +L+ A + +A +HD +H G
Sbjct: 604 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 662
Query: 276 TNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIE 335
TN+F S+ A+LYND +VLE+HH + A++L D + NI N+ ++ +R R +I+
Sbjct: 663 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 722
Query: 336 MVMATDMSCHFQQIKAMKTALQQPEAIE--------KPKALS----------LMLHTADI 377
MV+AT+M+ HF+ + ++ +P A E P + +M+ AD+
Sbjct: 723 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 782
Query: 378 SHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLP-FSPLCDRKSTMVAQSQVGFIDFIVE 436
++P + DL W + EE+F Q D E GLP P+ DR + + +SQ+ FID+ +
Sbjct: 783 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 842
Query: 437 PTF 439
F
Sbjct: 843 DMF 845
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 159 bits (402), Expect = 7e-39
Identities = 89/272 (32%), Positives = 147/272 (54%), Gaps = 9/272 (3%)
Query: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
L+ V W+FD+F + + ++L + + L + + LI F + + L F+ ++ Y
Sbjct: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
Query: 223 HKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQ 282
+NPYHN +HAADVTQ +H L + +AN +T +I + +AA HD +H G F I+
Sbjct: 208 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 266
Query: 283 TRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDM 342
T A LY + SVLENHH +A LL+ E + +L + ++ T + +++ATD+
Sbjct: 267 TNHYLATLYKNTSVLENHHWRSAVGLLR---ESGLFSHLPLESRQQMETQIGALILATDI 323
Query: 343 SCHFQQIKAMKTALQQ-----PEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEE 397
S + + ++ L + + + L + L ADI +P + W+L +W+ + EE
Sbjct: 324 SRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEE 383
Query: 398 FFRQGDREAELGLPFSPLCDRKSTMVAQSQVG 429
FF QGD E + L SPLCDR + +A Q+G
Sbjct: 384 FFHQGDIEKKYHLGVSPLCDRHTESIANIQIG 415
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 146 bits (368), Expect = 6e-35
Identities = 97/349 (27%), Positives = 175/349 (50%), Gaps = 18/349 (5%)
Query: 157 PAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEAL 216
P IEAL+ K +FDV+ L+ ++++L L+ F I L ++ +
Sbjct: 43 PETIEALR---KPTFDVWLWEPNEMLSCLEHMYHDL----GLVRDFSINPVTLRRWLFCV 95
Query: 217 EVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTT 276
Y NP+HN H V Q ++ +++ + ++ +I ++ +A HD +H G
Sbjct: 96 HDNY--RNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN 153
Query: 277 NNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEM 336
N + I R++ A+ YND S LENHH + A+++L + E NI N+ D +++ R +I +
Sbjct: 154 NTYQINARTELAVRYNDISPLENHHCAVAFQILA-EPECNIFSNIPPDGFKQIRQGMITL 212
Query: 337 VMATDMSCHFQQIKAMKTALQQPE-AIEKPKAL--SLMLHTADISHPAKAWDLHHRWTMS 393
++ATDM+ H + + + K ++ + + E+ L +++ DIS+ + ++ W
Sbjct: 213 ILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDC 272
Query: 394 LLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDM----TEKI 449
LLEE+F Q DRE GLP +P DR A +Q+GFI F++ P F +T + E +
Sbjct: 273 LLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIM 332
Query: 450 VSPLIDETSQTGGTGQRRSSLNSI-SSSDAKRSGVKTSGSEGSAPINNS 497
+ PL + + + ++ + +D+ SG E S + NS
Sbjct: 333 LQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNS 381
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,933,175
Number of Sequences: 37866
Number of extensions: 927982
Number of successful extensions: 9638
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 270
Number of HSP's successfully gapped in prelim test: 425
Number of HSP's that attempted gapping in prelim test: 5760
Number of HSP's gapped (non-prelim): 3005
length of query: 634
length of database: 18,247,518
effective HSP length: 108
effective length of query: 526
effective length of database: 14,157,990
effective search space: 7447102740
effective search space used: 7447102740
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.