Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 4826772

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4826772 insulin-like growth factor binding protein, acid
labile subunit isoform 2 precursor [Homo sapiens]
         (605 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4826772 insulin-like growth factor binding protein, acid labi...  1214   0.0  
gi|225579152 insulin-like growth factor binding protein, acid la...  1206   0.0  
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   192   6e-49
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   192   6e-49
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   183   5e-46
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   172   8e-43
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   167   3e-41
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...   164   3e-40
gi|194440719 chondroadherin-like [Homo sapiens]                       162   1e-39
gi|4758460 glycoprotein V (platelet) [Homo sapiens]                   161   2e-39
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]               159   9e-39
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   158   1e-38
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]                  155   8e-38
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]                  154   2e-37
gi|62912472 leucine-rich repeat-containing G protein-coupled rec...   152   9e-37
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   150   2e-36
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]    147   3e-35
gi|193083139 leucine rich repeat containing 32 precursor [Homo s...   146   6e-35
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap...   146   6e-35
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...   145   1e-34
gi|4507531 toll-like receptor 3 [Homo sapiens]                        144   2e-34
gi|198041768 synleurin [Homo sapiens]                                 142   7e-34
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...   141   2e-33
gi|110825984 malignant fibrous histiocytoma amplified sequence 1...   140   3e-33
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...   140   3e-33
gi|45505137 podocan [Homo sapiens]                                    140   4e-33
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo...   136   6e-32
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...   136   6e-32
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]             131   2e-30
gi|188528675 slit homolog 1 [Homo sapiens]                            130   5e-30

>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score = 1214 bits (3142), Expect = 0.0
 Identities = 605/605 (100%), Positives = 605/605 (100%)

Query: 1   MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFC 60
           MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFC
Sbjct: 1   MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFC 60

Query: 61  SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 120
           SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG
Sbjct: 61  SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 120

Query: 121 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 180
           LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN
Sbjct: 121 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 180

Query: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 240
           SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ
Sbjct: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 240

Query: 241 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 300
           LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN
Sbjct: 241 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 300

Query: 301 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 360
           AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG
Sbjct: 301 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 360

Query: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
           LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN
Sbjct: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420

Query: 421 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
           GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP
Sbjct: 421 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480

Query: 481 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDC 540
           LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDC
Sbjct: 481 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDC 540

Query: 541 GCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEA 600
           GCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEA
Sbjct: 541 GCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEA 600

Query: 601 HFAPC 605
           HFAPC
Sbjct: 601 HFAPC 605


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score = 1206 bits (3119), Expect = 0.0
 Identities = 600/600 (100%), Positives = 600/600 (100%)

Query: 6   GGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNL 65
           GGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNL
Sbjct: 44  GGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNL 103

Query: 66  TRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLC 125
           TRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLC
Sbjct: 104 TRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLC 163

Query: 126 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 185
           HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL
Sbjct: 164 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 223

Query: 186 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 245
           PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ
Sbjct: 224 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 283

Query: 246 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 305
           KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL
Sbjct: 284 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 343

Query: 306 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 365
           RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA
Sbjct: 344 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 403

Query: 366 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 425
           VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI
Sbjct: 404 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 463

Query: 426 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF 485
           EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF
Sbjct: 464 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF 523

Query: 486 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK 545
           WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK
Sbjct: 524 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK 583

Query: 546 ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 605
           ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC
Sbjct: 584 ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 643


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  192 bits (489), Expect = 6e-49
 Identities = 154/472 (32%), Positives = 210/472 (44%), Gaps = 61/472 (12%)

Query: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
           N   L +    +  L    F +  AL +L +  N LSR+  G F  LGSL  L+L  N L
Sbjct: 60  NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 119

Query: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242
            VLP   F+GL SL  L+L+ N+L  +QPA FS  + L+EL L  N L  I    F  L 
Sbjct: 120 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 179

Query: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302
            L KL L +N +  ++P  F  L  L+ L L  NR+  +   TF GL+ L+ L L  N I
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239

Query: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362
             L P  F + H L+ L L +N I QL    F  L QL  LTL  N L+E+  G F  + 
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 299

Query: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
           N+  + L  N + +LP+ VF  L +L  L L  + +  I P  F GL+            
Sbjct: 300 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLT------------ 347

Query: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
                       EL EL L +N L  L   +F+ L  L+ + L  NRL +LP +    + 
Sbjct: 348 ------------ELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVN 395

Query: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGC 542
               + + +N+LE LP  +   LG+L  L L +                    NPW C  
Sbjct: 396 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD--------------------NPWRCDS 435

Query: 543 PLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDL 594
            +  LR++ L N    PR       G D  P         C SP  V G  L
Sbjct: 436 DILPLRNWLLLNQ---PRL------GTDTVP--------VCFSPANVRGQSL 470



 Score =  185 bits (469), Expect = 1e-46
 Identities = 136/431 (31%), Positives = 212/431 (49%), Gaps = 11/431 (2%)

Query: 41  CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
           CP+ C CS     +     C+   +  +P  +P    +L +   +++ +  + F N+S+L
Sbjct: 31  CPSECTCSRASQVE-----CTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 85

Query: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
             L ++  +L  + P A   L +L +L L  N+L+ L +G F    +L SL LS+N+L +
Sbjct: 86  IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 145

Query: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
           ++   F    +L +L L  N L  +PD AF  L  L +L L  N L ++ P +F  L  L
Sbjct: 146 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 205

Query: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
           + L L  N L  I    F  L  LQ+L L +N I  ++PG F     L+ L LS+N ++ 
Sbjct: 206 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 265

Query: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
           L    F  L  L  L L  N++  L    F  +  L EL L  N I  L +  F  L QL
Sbjct: 266 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 325

Query: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 400
           +VL L  NQ+  +  GAF GLT +  ++L  N L++L   VFR L  L ++ L+ + L +
Sbjct: 326 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 385

Query: 401 IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKL 460
           +  + F  ++GL  + L++N L  +       L +L EL L  N     P R    +  L
Sbjct: 386 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN-----PWRCDSDILPL 440

Query: 461 -EYLLLSRNRL 470
             +LLL++ RL
Sbjct: 441 RNWLLLNQPRL 451


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  192 bits (489), Expect = 6e-49
 Identities = 154/472 (32%), Positives = 210/472 (44%), Gaps = 61/472 (12%)

Query: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
           N   L +    +  L    F +  AL +L +  N LSR+  G F  LGSL  L+L  N L
Sbjct: 54  NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113

Query: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242
            VLP   F+GL SL  L+L+ N+L  +QPA FS  + L+EL L  N L  I    F  L 
Sbjct: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 173

Query: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302
            L KL L +N +  ++P  F  L  L+ L L  NR+  +   TF GL+ L+ L L  N I
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233

Query: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362
             L P  F + H L+ L L +N I QL    F  L QL  LTL  N L+E+  G F  + 
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293

Query: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
           N+  + L  N + +LP+ VF  L +L  L L  + +  I P  F GL+            
Sbjct: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLT------------ 341

Query: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
                       EL EL L +N L  L   +F+ L  L+ + L  NRL +LP +    + 
Sbjct: 342 ------------ELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVN 389

Query: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGC 542
               + + +N+LE LP  +   LG+L  L L +                    NPW C  
Sbjct: 390 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD--------------------NPWRCDS 429

Query: 543 PLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDL 594
            +  LR++ L N    PR       G D  P         C SP  V G  L
Sbjct: 430 DILPLRNWLLLNQ---PRL------GTDTVP--------VCFSPANVRGQSL 464



 Score =  185 bits (469), Expect = 1e-46
 Identities = 136/431 (31%), Positives = 212/431 (49%), Gaps = 11/431 (2%)

Query: 41  CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
           CP+ C CS     +     C+   +  +P  +P    +L +   +++ +  + F N+S+L
Sbjct: 25  CPSECTCSRASQVE-----CTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 79

Query: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
             L ++  +L  + P A   L +L +L L  N+L+ L +G F    +L SL LS+N+L +
Sbjct: 80  IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 139

Query: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
           ++   F    +L +L L  N L  +PD AF  L  L +L L  N L ++ P +F  L  L
Sbjct: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 199

Query: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
           + L L  N L  I    F  L  LQ+L L +N I  ++PG F     L+ L LS+N ++ 
Sbjct: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259

Query: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
           L    F  L  L  L L  N++  L    F  +  L EL L  N I  L +  F  L QL
Sbjct: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 319

Query: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 400
           +VL L  NQ+  +  GAF GLT +  ++L  N L++L   VFR L  L ++ L+ + L +
Sbjct: 320 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 379

Query: 401 IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKL 460
           +  + F  ++GL  + L++N L  +       L +L EL L  N     P R    +  L
Sbjct: 380 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN-----PWRCDSDILPL 434

Query: 461 -EYLLLSRNRL 470
             +LLL++ RL
Sbjct: 435 RNWLLLNQPRL 445


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score =  183 bits (464), Expect = 5e-46
 Identities = 139/436 (31%), Positives = 208/436 (47%), Gaps = 17/436 (3%)

Query: 13  LLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGV 72
           LLL W+ L        +P T        C AAC C+ D      S+ C  R L  LP  +
Sbjct: 18  LLLLWLLL-----LRLEPVTAAAGPRAPCAAACTCAGD------SLDCGGRGLAALPGDL 66

Query: 73  PGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERN 132
           P  T++L L  N LS + PA F++L +L  + L   +L ++ P       ++  L L+ N
Sbjct: 67  PSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHN 125

Query: 133 QLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRG 192
           ++RS+         +L  L LS N ++ + +  F     + +LNL  N +  L   AF G
Sbjct: 126 KIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDG 185

Query: 193 LG-SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR 251
           L  SL  L L+ NR+  L    F  L  L +LDL+RN +R I+   F  L  L+ L L R
Sbjct: 186 LSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQR 244

Query: 252 NLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFK 311
           N I+ +  GAF GL  +  L L +N +  +   +  GL  L  L LS+N+IA +  + + 
Sbjct: 245 NNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWS 304

Query: 312 DLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSG 371
               L EL L  N + +L E S   L  L VL L HN +  +  GAF GL ++ V++L  
Sbjct: 305 FCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDH 364

Query: 372 NCLRNLPEQ---VFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQ 428
           N +    E     F GL  L  L L G+ +  +    F+GL GL  L L  N +  ++  
Sbjct: 365 NEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFD 424

Query: 429 SLWGLAELLELDLTSN 444
           +   +  L EL ++S+
Sbjct: 425 AFVKMKNLKELHISSD 440



 Score =  154 bits (390), Expect = 2e-37
 Identities = 127/424 (29%), Positives = 198/424 (46%), Gaps = 16/424 (3%)

Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
           LNL +N L+ +  A F  L +L+E+ L  N L  + P+L +  + +  L L  N +R+++
Sbjct: 73  LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSVE 131

Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-GLR 293
            +       L+ L L  N I  V    F     ++ L+L+ NR+  L    F GL   L 
Sbjct: 132 GSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLL 191

Query: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV 353
            LRLS N I  L  R FK L  L +L L  NRIR +   +F+GL  LEVL L  N + ++
Sbjct: 192 TLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKL 250

Query: 354 KAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLR 413
             GAF GL+ + V++L  N L  +      GL  LH LHL  + + RI    ++    L 
Sbjct: 251 TDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLH 310

Query: 414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA-- 471
            L L  N L  ++E+SL  L+ L  L L+ N ++H+    F+GL  L  L L  N ++  
Sbjct: 311 ELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGT 370

Query: 472 -ELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPP 526
            E  + A   L     L +  N+++++     + L  L +L+L  N++R+       +  
Sbjct: 371 IEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMK 430

Query: 527 GLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP 586
            L+ L +  + + C C LK L       P  + R +QA        P +    +I    P
Sbjct: 431 NLKELHISSDSFLCDCQLKWL------PPWLIGRMLQAFVTATCAHPESLKGQSIFSVPP 484

Query: 587 PEVV 590
              V
Sbjct: 485 ESFV 488



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 48/154 (31%), Positives = 72/154 (46%), Gaps = 3/154 (1%)

Query: 79  LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLA 138
           L L  N+++ +    +     L  L L    L  L+ ++L  L +L  L L  N +  +A
Sbjct: 288 LHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIA 347

Query: 139 LGTFAHTPALASLGLSNNRLS-RLED--GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGS 195
            G F    +L  L L +N +S  +ED  G F GL SL  L L  N +  +   AF GL  
Sbjct: 348 EGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEG 407

Query: 196 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNA 229
           L  L L GN +  +Q   F  +  L+EL +S ++
Sbjct: 408 LEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDS 441


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  172 bits (436), Expect = 8e-43
 Identities = 138/449 (30%), Positives = 215/449 (47%), Gaps = 16/449 (3%)

Query: 14  LLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVP 73
           LL ++ALG     G     P  A  P C A C C  D   D     CS + LT +P+G+ 
Sbjct: 7   LLCFLALGLLGSAG-----PSGAAPPLCAAPCSCDGDRRVD-----CSGKGLTAVPEGLS 56

Query: 74  GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 133
             TQAL +  NN++ +P  AF+N   L  L L G  L  + P+AL GL+ L  L L+ NQ
Sbjct: 57  AFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQ 116

Query: 134 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 193
           L+++         AL SL L  N ++ + +  FEGL  L  L L  NSL  +P      L
Sbjct: 117 LKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176

Query: 194 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 253
            +L+ L LA N+++ +    F+ L+ L  L L  N +R++  + F  L  L+ L L+ N 
Sbjct: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236

Query: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 313
           +    P A   L +L+ L    N ++ + +  F G   LR + L  N ++ +    F +L
Sbjct: 237 LGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295

Query: 314 HFLEELQL-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
             L  L + G + ++Q    +  G   LE LTL   ++  +          +  ++LS N
Sbjct: 296 SDLHSLVIRGASMVQQFP--NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353

Query: 373 CLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWG 432
            +R+LP   F G   L  + L+ + + +I+  TF GL  LR L L  N +  I  ++   
Sbjct: 354 NIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFAT 411

Query: 433 LAELLELDLTSNQLTHLPHRLFQGLGKLE 461
           L  +  LD++ N+LT  P     GL +L+
Sbjct: 412 LGPITNLDVSFNELTSFPTEGLNGLNQLK 440



 Score =  150 bits (379), Expect = 3e-36
 Identities = 120/394 (30%), Positives = 183/394 (46%), Gaps = 26/394 (6%)

Query: 167 EGLGSLWD-LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDL 225
           EGL +    L++  N++  LP+ AF+    L EL LAGN L+++ P   SGL EL+ L L
Sbjct: 53  EGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL 112

Query: 226 SRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDT 285
             N L+ + +     L  LQ L LD N I +V   +F GL  LR L L  N +  +    
Sbjct: 113 QNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHP 172

Query: 286 FPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTL 345
              L  L+ L L+ N I+S+    F +L  L  L L +N+IR L++  F+GL  LE L L
Sbjct: 173 LSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232

Query: 346 DHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT 405
           ++N L E    A   L ++  +    N +  +P+  F G   L ++HL  + L  +    
Sbjct: 233 NYNNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSA 291

Query: 406 FTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRL------------ 453
           F  LS L  L ++   +V  +  +L G   L  L LT  +++ +P+ L            
Sbjct: 292 FHNLSDLHSLVIRGASMVQ-QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL 350

Query: 454 ----------FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 503
                     F G   LE + L RN++ ++       L     LD+S N +  + +   A
Sbjct: 351 SYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFA 410

Query: 504 PLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 536
            LG +  L +  N L +F T    GL +L L GN
Sbjct: 411 TLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGN 444


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  167 bits (423), Expect = 3e-41
 Identities = 143/440 (32%), Positives = 206/440 (46%), Gaps = 12/440 (2%)

Query: 31  GTPGEAEGP-ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 89
           G P    GP ACPA C C   +D   LS  CS   L+ +P  +   T  L L  NNL+ +
Sbjct: 24  GAPQPGPGPTACPAPCHCQ--EDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTEL 81

Query: 90  PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 149
            P  F +L  L  L L G  L  +  QA  GL +L  L L+ NQL  +        P+L 
Sbjct: 82  QPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQ 141

Query: 150 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 209
           SL L  N +S + +  FEGL SL  L L  N+L  +P  A   L +L+ + LA NR++++
Sbjct: 142 SLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHI 201

Query: 210 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 269
               F  L  L  L L  N ++ +  + F  L  L+ L L+ N +    P A   L  L+
Sbjct: 202 PDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQ 260

Query: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQL-GHNRIRQ 328
            L   +N +  + E  F G   L+ +    N I  +    F+ L  L  L L G   I++
Sbjct: 261 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE 320

Query: 329 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 388
             +   +G   LE+LTL    ++ + +G    L  + V+ LS N +  LP        KL
Sbjct: 321 FPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKL 376

Query: 389 HSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTH 448
             + L+ + +  I   TF+ LS L+ L L  N +  I  ++   L  L++LDLT NQLT 
Sbjct: 377 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 436

Query: 449 LPHRLFQGLGKLEYLLLSRN 468
           LP     GLG L +L L  N
Sbjct: 437 LP---LAGLGGLMHLKLKGN 453



 Score =  154 bits (388), Expect = 3e-37
 Identities = 119/351 (33%), Positives = 174/351 (49%), Gaps = 6/351 (1%)

Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
           L+L  N+L  L    F  L  L EL L+GN L+++    FSGL  L+ L L  N L  I 
Sbjct: 71  LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130

Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
           A    +LP LQ L LD NLI+ V   +F GL +LR L L  N +  +       L  L+ 
Sbjct: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190

Query: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
           + L+ N I+ +    F++L  L  L L +NRI+ L   SFEGL  LE L L++N+LQE  
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250

Query: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 414
             A   L  +  +    N ++ +PE+ F G   L ++H   + +  +    F  L  L  
Sbjct: 251 V-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309

Query: 415 LFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAEL 473
           L L  NG + I+E   L G   L  L LT   +  LP  + Q L +L  L LS N++ EL
Sbjct: 310 LSL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 367

Query: 474 PADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 524
           P  +L   Q+   + + HNR+  +     + L  L+ L L  N++R+  P+
Sbjct: 368 P--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416



 Score =  150 bits (380), Expect = 2e-36
 Identities = 124/394 (31%), Positives = 189/394 (47%), Gaps = 9/394 (2%)

Query: 146 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNR 205
           P  A L LS N L+ L+ GLF  L  L +L L  N L+ +P  AF GL SL+ L+L  N+
Sbjct: 66  PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 125

Query: 206 LAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGL 265
           L  +       L  L+ L L  N +  +    F  L  L+ L+LD N +  +   A   L
Sbjct: 126 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 185

Query: 266 KALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNR 325
            AL+ + L+ NR++ + +  F  L  L VL L +N I  L   +F+ LH LE L L +N+
Sbjct: 186 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 245

Query: 326 IRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGL 385
           +++    +   LG+L+ L   +N ++ +   AF+G   +  ++   N ++ +    F+ L
Sbjct: 246 LQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 304

Query: 386 GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQ 445
            KLH+L L G+   +  P    G + L  L L   G+  +       L  L  L+L+ NQ
Sbjct: 305 PKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 363

Query: 446 LTHLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 503
           +  LP  HR      KLE + L  NR+ E+ AD    L     LD+S N + ++     +
Sbjct: 364 IEELPSLHR----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFS 419

Query: 504 PLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 536
            L  L  L L +N L T       GL  L L+GN
Sbjct: 420 TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 453


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score =  164 bits (414), Expect = 3e-40
 Identities = 142/477 (29%), Positives = 219/477 (45%), Gaps = 43/477 (9%)

Query: 2   ALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPA----CPAACVCSYDDDADELS 57
           +LR     L LLL + +    RS  G   G  G+  G A    CP  C C  D       
Sbjct: 5   SLRARAAGLGLLLCAVLGRAGRSDSGGR-GELGQPSGVAAERPCPTTCRCLGD------L 57

Query: 58  VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 117
           + CS + L RLP+ +P     L L  N LS +  ++  +L SL  + L   +L ++ P  
Sbjct: 58  LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNL 116

Query: 118 LLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNL 177
                N+  L L  N++  +         +L +L LS+N +S L+               
Sbjct: 117 GPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ--------------- 161

Query: 178 GWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE-LRELDLSRNALRAIKAN 236
                      AF  L  L+ L L  NR+  ++P  F  LA  L  L L+RN + AI   
Sbjct: 162 ----------TAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK 210

Query: 237 VFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLR 296
           +F +LP+LQ L L+RN I  V    F GL AL+ L +  N V  L++  F GL  + +L+
Sbjct: 211 MF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQ 269

Query: 297 LSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAG 356
           L HN +  +       L  L+EL L  N I +++  ++E   +L  L L  N L  +   
Sbjct: 270 LDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDS 329

Query: 357 AFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG---RIRPHTFTGLSGLR 413
           +FLGL+ +  +++  N +  + +  FRGL  L +L L+ + +          F+GL  LR
Sbjct: 330 SFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLR 389

Query: 414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 470
           RL L+ N +  I +++  GL  L  LDL+ N +  L    F  + KL+ L L+ + L
Sbjct: 390 RLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446



 Score =  143 bits (360), Expect = 5e-34
 Identities = 122/426 (28%), Positives = 200/426 (46%), Gaps = 36/426 (8%)

Query: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 207
           +A L LS+NRLS ++      L SL ++ L  N L  +P+       ++  L LAGNR+ 
Sbjct: 76  VARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIV 134

Query: 208 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 267
            + P        L  LDLS N +  ++   F  L +L+ LYL+ N + ++ PG F  L  
Sbjct: 135 EILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLAN 192

Query: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
                                   L VL+L+ N I+++ P+ FK L  L+ L+L  N+I+
Sbjct: 193 T-----------------------LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIK 228

Query: 328 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 387
            +   +F+GLG L+ L +  N + ++  GAF GL+N+ ++ L  N L  + +    GL  
Sbjct: 229 NVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLM 288

Query: 388 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 447
           L  LHL  + + RI P  +     L  L L  N L  +++ S  GL+ L  L + +N+++
Sbjct: 289 LQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVS 348

Query: 448 HLPHRLFQGLGKLEYLLLSRNRLAELPAD---ALGPLQRAFWLDVSHNRLEALPNSLLAP 504
           ++    F+GL  L+ L L  N ++    D   A   L +   L +  NR+ ++       
Sbjct: 349 YIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTG 408

Query: 505 LGRLRYLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPR 560
           L  L +L L +N++ +       Q   L++L L  +   C C LK L  +  +N      
Sbjct: 409 LDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN--NFQS 466

Query: 561 FVQAIC 566
           FV A C
Sbjct: 467 FVNASC 472


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  162 bits (409), Expect = 1e-39
 Identities = 184/607 (30%), Positives = 240/607 (39%), Gaps = 107/607 (17%)

Query: 35  EAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAF 94
           +A    CP AC+C    D     V C  +NLT +PD +P  TQ L L GN L  +P AAF
Sbjct: 27  QAAAQRCPQACIC----DNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAF 82

Query: 95  QN------------------------LSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 130
           Q                         L  L  LNL    L  L  +AL GL +L  L LE
Sbjct: 83  QGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELE 142

Query: 131 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 190
            N L  L  GTF    ALA+L L++N L  L    F+GL  +  L L  N+L+VL   A 
Sbjct: 143 GNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEAL 202

Query: 191 RGLGSLRELVLAGNRLAYL------------------QPALFSG------LAELRELDLS 226
            GL +LR L L  N L  L                   P  ++G      L  LREL L 
Sbjct: 203 AGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLD 262

Query: 227 RNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN------RVAG 280
             AL+A+    F   PRL  L L  N +  + P    G   LR L L  N      +   
Sbjct: 263 GGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARP 320

Query: 281 LLEDTFPGLLGLRVL---------RLSHNAIASLRPRTFK-------DLHFLEELQL--- 321
           LLE     L   RV          RL   A+ +LRP   +       +   LEE  +   
Sbjct: 321 LLE----WLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGP 376

Query: 322 -----------GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLS 370
                      G  R      R+   + +    + +   LQ V  G     ++  +++L 
Sbjct: 377 RAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGF---PSDTQLLDLR 433

Query: 371 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 430
            N   ++P   F GLG L SLHL+   +  +      GL  L  L+L DN L G+   +L
Sbjct: 434 RNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAAL 493

Query: 431 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 490
            G   L  L L  N+   +P    + L  L  L L  N +  L    LG  +   W+ +S
Sbjct: 494 EGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLS 553

Query: 491 HNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPLKA 546
            NR+  +    L P   L  L L  N LR          P L  L L GN      PL+A
Sbjct: 554 GNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGN------PLRA 607

Query: 547 LRDFALQ 553
           LRD A Q
Sbjct: 608 LRDGAFQ 614



 Score =  125 bits (314), Expect = 1e-28
 Identities = 102/307 (33%), Positives = 139/307 (45%), Gaps = 9/307 (2%)

Query: 21  GPRSLEGADPGTPGEAEGPA-CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQAL 79
           GPR+     P  PGE    A CP ACVC  +         C    L  +P G P  TQ L
Sbjct: 375 GPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSS----CEGCGLQAVPRGFPSDTQLL 430

Query: 80  WLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLAL 139
            L  N+  SVP AAF  L  L  L+LQ   +  LE  AL GL  L +L+L  NQL  L+ 
Sbjct: 431 DLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSA 490

Query: 140 GTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLREL 199
                 P L  L L  NR  ++       L SL+ L+L  N++  L         +LR +
Sbjct: 491 AALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWV 550

Query: 200 VLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAP 259
            L+GNR+  +         EL +L L RN LR +       LP L +L L  N + A+  
Sbjct: 551 YLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRD 610

Query: 260 GAFLGL-KALRWLDLSHNRVAGLLEDTFPGL-LGLRVLRLSHNAIASLRPRTFKDLHFLE 317
           GAF  + ++L+ L L+ + +  +    F GL  GL+ L L  N + +L       L  LE
Sbjct: 611 GAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLE 668

Query: 318 ELQLGHN 324
            + L  N
Sbjct: 669 LIDLSSN 675



 Score =  112 bits (279), Expect = 1e-24
 Identities = 154/551 (27%), Positives = 206/551 (37%), Gaps = 93/551 (16%)

Query: 71  GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 130
           G  G    L L  N L  +P  AFQ L  + +L L    L  L P+AL GL  L  L L 
Sbjct: 155 GALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLH 214

Query: 131 RNQLRSL----------------------------------------------ALG--TF 142
            N+L++L                                              ALG   F
Sbjct: 215 HNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAF 274

Query: 143 AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL----------------AVLP 186
           AH P L +L L  N+L  L     +G G L  L L  N L                 V  
Sbjct: 275 AHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRS 332

Query: 187 DAAFRGLGSLRELVLAGNRLAYLQP--ALFSGLAELRELDLSRNALRAIKANVFVQLPRL 244
           D A +G   LR     G  L  L+P      G A   E +L   A+   +A      PR 
Sbjct: 333 DGACQGPRRLR-----GEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAP-----PRG 382

Query: 245 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL----LEDTFPGLLGLRVLRLSHN 300
                      A  P A + +   R     H+   G     +   FP     ++L L  N
Sbjct: 383 PPRGPGEERAVAPCPRACVCVPESR-----HSSCEGCGLQAVPRGFPS--DTQLLDLRRN 435

Query: 301 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 360
              S+    F  L  L  L L H  I +L   +  GLG+L  L L  NQL  + A A  G
Sbjct: 436 HFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEG 495

Query: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
              +  + L  N    +P    R L  L SLHL+ + + R+ P        LR ++L  N
Sbjct: 496 APRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGN 555

Query: 421 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
            +  +   +L    EL +L L  NQL  +P    +GL  L  L LS N L  L   A  P
Sbjct: 556 RITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQP 615

Query: 481 LQRAF-WLDVSHNRLEALPNSLLAPLG-RLRYLSLRNNSLRTF--TPQPPGLERLWLEGN 536
           + R+   L ++ + LE +     + LG  L+ L L+ N LR     P    LE + L  N
Sbjct: 616 VGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSN 675

Query: 537 PWDCGCPLKAL 547
           P+ C C L  L
Sbjct: 676 PFHCDCQLLPL 686



 Score =  105 bits (262), Expect = 1e-22
 Identities = 106/291 (36%), Positives = 137/291 (47%), Gaps = 35/291 (12%)

Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
           L+L  N    +P AAF GLG L  L L    +A L+    +GL  L  L LS N L  + 
Sbjct: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489

Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
           A      PRL  LYL+RN    V PGA     ALR L               P L  L  
Sbjct: 490 AAALEGAPRLGYLYLERNRFLQV-PGA-----ALRAL---------------PSLFSLH- 527

Query: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
             L  NA+  L P        L  + L  NRI +++  +     +LE L LD NQL+EV 
Sbjct: 528 --LQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVP 585

Query: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK-LHSLHLEGSCLGRIRPHTFTGLS-GL 412
            GA  GL  +  + LSGN LR L +  F+ +G+ L  L L  S L +I P  F+GL  GL
Sbjct: 586 TGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGL 645

Query: 413 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSN------QLTHLPHRLFQGL 457
           + L L+ N L  +   +L  L++L  +DL+SN      QL  L HR   GL
Sbjct: 646 QSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPL-HRWLTGL 693


>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
          Length = 560

 Score =  161 bits (407), Expect = 2e-39
 Identities = 122/360 (33%), Positives = 172/360 (47%), Gaps = 1/360 (0%)

Query: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
           L+   F G+  L  L +  + ++ +    F  L  L+ L L+ N++ +L  AL   +  L
Sbjct: 65  LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124

Query: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
            +L L  NALR I  N+F +L  LQ+L L++N +  +    F  L+ L+ LDLS N +  
Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184

Query: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
           L +        L  L L  N + SL       L  L ELQ   N IR +A  +F+ L  L
Sbjct: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNL 244

Query: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 400
             LTL  N L  + +  FL   N+ ++ L  N L  LP  +F  +G L  L L  + L  
Sbjct: 245 SSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRT 304

Query: 401 IRPHTFTGLSGLRRLFLK-DNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 459
           +    F  LS LR L +     L  + + +  GL EL  L L SN LT LP  L +GLGK
Sbjct: 305 LPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGK 364

Query: 460 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR 519
           L  + L RNRL  LP      L     + + HN+LE LP  +   L RL  + L +NS R
Sbjct: 365 LRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424



 Score =  155 bits (391), Expect = 1e-37
 Identities = 133/453 (29%), Positives = 200/453 (44%), Gaps = 53/453 (11%)

Query: 41  CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
           CP AC C + D A      CS  ++ R+         AL L  N               L
Sbjct: 21  CPPACKCVFRDAAQ-----CSGGDVARI--------SALGLPTN---------------L 52

Query: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
             + L G   G L+ Q+  G+  L  L +  + + ++A GTF+    L +L LS N+++ 
Sbjct: 53  THILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITH 112

Query: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
           L   L + +  L  L L  N+L  +    F+ L +L+EL L  N+L +L  +LF+ L  L
Sbjct: 113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENL 172

Query: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
           + LDLS N L  +   +     +L++L L  N + ++  G    L AL  L    N +  
Sbjct: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232

Query: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
           +    F  L  L  L LS N +A L    F   H L  L L  N + +L    F  +G L
Sbjct: 233 IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292

Query: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLS-GNCLRNLPEQVFRGLGKLHSLHLEGSCLG 399
           + L L+  QL+ + A AF  L+ +  + ++    L  LP+  F+GLG+L  L L      
Sbjct: 293 QELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALH----- 347

Query: 400 RIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 459
                               NGL  + +  L GL +L ++ L  N+L  LP  LF+ L  
Sbjct: 348 -------------------SNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSS 388

Query: 460 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHN 492
           LE + L  N+L  LP D  G L R   + + HN
Sbjct: 389 LESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421



 Score =  118 bits (296), Expect = 1e-26
 Identities = 95/295 (32%), Positives = 134/295 (45%), Gaps = 28/295 (9%)

Query: 261 AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQ 320
           +F G+  L+ L +S + ++ +   TF  L+ L+ LRLS N I  L       +  LE+L 
Sbjct: 69  SFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLF 128

Query: 321 LGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPE- 379
           L HN +R + +  F+ L  L+ L L+ NQL  + A  F  L N+ +++LSGN L +LP+ 
Sbjct: 129 LDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKG 188

Query: 380 -----------------------QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLF 416
                                   +   LG L  L    + +  I P  F  L  L  L 
Sbjct: 189 LLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLT 248

Query: 417 LKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPAD 476
           L  N L  +          L  L L  N L  LP  LF  +G L+ L L+R +L  LPA 
Sbjct: 249 LSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAA 308

Query: 477 ALGPLQRAFWLDVSHN-RLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 530
           A   L R  +L V+ + RL ALP      LG L+ L+L +N L   T  P GL R
Sbjct: 309 AFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGL---TALPDGLLR 360



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 58/161 (36%), Positives = 76/161 (47%), Gaps = 23/161 (14%)

Query: 71  GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 130
           G  GG Q LWL+   L ++P AAF+NLS L +L +      +L P+              
Sbjct: 287 GEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGV------TLSPR-------------- 326

Query: 131 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 190
              L +L  G F     L  L L +N L+ L DGL  GLG L  ++L  N L  LP A F
Sbjct: 327 ---LSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALF 383

Query: 191 RGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALR 231
           R L SL  + L  N+L  L   +F  L  L E+ L  N+ R
Sbjct: 384 RNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 54/161 (33%), Positives = 76/161 (47%), Gaps = 1/161 (0%)

Query: 359 LGL-TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFL 417
           LGL TN+  + L G     L  Q F G+  L  L +  S +  + P TF+ L  L+ L L
Sbjct: 46  LGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRL 105

Query: 418 KDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADA 477
             N +  +    L  +  L +L L  N L  +   +FQ L  L+ L L++N+L  LPA  
Sbjct: 106 SRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASL 165

Query: 478 LGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
              L+    LD+S N L  LP  LL    +L  L L +N L
Sbjct: 166 FTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score =  159 bits (401), Expect = 9e-39
 Identities = 119/340 (35%), Positives = 162/340 (47%), Gaps = 11/340 (3%)

Query: 39  PACPAACVCSYDDDADELSVFCSSRNLTRLP--DGVPGGTQALW--LDGNNLSSVPPAAF 94
           P CP  C C +        + C++R L  +P    +P     L   L GN ++++    F
Sbjct: 25  PVCPERCDCQHPQH-----LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDF 79

Query: 95  QNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLS 154
             L  L  L+LQ  Q+ SL P+    L  L  L+L  N L++LA GT A    L  L  +
Sbjct: 80  HRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYAN 139

Query: 155 NNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALF 214
            N +SRL  G FEGL SL  L L  N+L  LPDA F  LG+L  L L  NR+ +L    F
Sbjct: 140 GNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAF 199

Query: 215 SGLAELRELDLSRNALRAI--KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 272
           + L +LR L+LS N L+     A  F  L  L  L L  N +  + P  F  L  L  L 
Sbjct: 200 AQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLS 259

Query: 273 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 332
           L  N++  L  + F GL  LR LRL  N ++ L     + LH LE L L  N +  L   
Sbjct: 260 LRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPA 319

Query: 333 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
           +F  LG+L  L+L +N L  +    F     +  ++L GN
Sbjct: 320 TFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359



 Score =  157 bits (396), Expect = 3e-38
 Identities = 114/306 (37%), Positives = 148/306 (48%), Gaps = 30/306 (9%)

Query: 273 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 332
           L  N +  +    F  L  LR L L +N I SL P+TF+ L  LEEL LG+N ++ LA  
Sbjct: 66  LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125

Query: 333 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH 392
           +   L +L +L  + N++  +  G+F GL ++  + L GN L  LP+ VF  LG L  LH
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185

Query: 393 LEG-----------SCLGRIR---------------PHTFTGLSGLRRLFLKDNGLVGIE 426
           LE            + LG++R                 TF  L  L  L L  N L  + 
Sbjct: 186 LESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLG 245

Query: 427 EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 486
            +    L  L  L L  NQLTHL    F GL  L  L L  NRL++LP   L PL     
Sbjct: 246 PRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEA 305

Query: 487 LDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGC 542
           LD+S N L AL  +    LGRLR LSLRNN+L   +       P L RL L+GN W C C
Sbjct: 306 LDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDC 365

Query: 543 PLKALR 548
            L+ L+
Sbjct: 366 RLRGLK 371



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 52/157 (33%), Positives = 78/157 (49%)

Query: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
           +V   +L GN + N+    F  LG+L  L L+ + +  + P TF  LS L  L+L +N L
Sbjct: 60  DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLL 119

Query: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
             +   +L  L +L  L    N+++ L    F+GL  L  L L  N L  LP     PL 
Sbjct: 120 QALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLG 179

Query: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR 519
              +L +  NR+  L  +  A LG+LR+L+L  N L+
Sbjct: 180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ 216


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  158 bits (400), Expect = 1e-38
 Identities = 118/331 (35%), Positives = 165/331 (49%), Gaps = 13/331 (3%)

Query: 55  ELSVFCSSRNLTRL-----------PDGVPG--GTQALWLDGNNLSSVPPAAFQNLSSLG 101
           E   F S+ NLT++           PD   G    + L + G++  ++    F NL+SLG
Sbjct: 65  ETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLG 124

Query: 102 FLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRL 161
            L L    L +L       L  L  LHL+ NQL++L    F     L +L L+ N L++L
Sbjct: 125 KLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQL 184

Query: 162 EDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELR 221
            + LF  L SL  L L  N+L+ LP   F  LGSL+EL L  N ++ L P +FS L  L 
Sbjct: 185 PEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLE 244

Query: 222 ELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL 281
            L L RNA+  +  ++F  L  L  L L  N++  +  G F     L  L L+HN++  +
Sbjct: 245 RLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304

Query: 282 LEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLE 341
            E TF  L  LR L LS+NAI  L    F+DL  L +L LG N +  L    F+ L +LE
Sbjct: 305 AEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLE 364

Query: 342 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
           +L+L  NQL  +  G F    N+  + L GN
Sbjct: 365 LLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395



 Score =  155 bits (392), Expect = 1e-37
 Identities = 125/383 (32%), Positives = 172/383 (44%), Gaps = 12/383 (3%)

Query: 41  CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAF---QNL 97
           CP  C C   +      VFCS   L  +P  +P  T+ +     + +++   AF    NL
Sbjct: 22  CPMGCDCFVQE------VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNL 75

Query: 98  SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 157
           + + FLN Q   L    P A  GL  L  L +  +   +L+   F++  +L  L L+ N 
Sbjct: 76  TKVVFLNTQ---LCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNM 132

Query: 158 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 217
           L  L +GLF+ L +L  L+L  N L  LP   F+ L  L+ L LA N LA L   LF  L
Sbjct: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192

Query: 218 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 277
             L+ L LS NAL  +   VF +L  LQ+L+LD N I+ + P  F  L  L  L L  N 
Sbjct: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA 252

Query: 278 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 337
           +  L    F  L  L  L L  N +  L    F     L  L L HN++  +AE +F  L
Sbjct: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312

Query: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 397
             L  L L +N +  + AG F  L  +  + L  N L  L   +F+ L KL  L L  + 
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372

Query: 398 LGRIRPHTFTGLSGLRRLFLKDN 420
           L  +    F     L  L L  N
Sbjct: 373 LTTLPEGIFDTNYNLFNLALHGN 395



 Score =  150 bits (379), Expect = 3e-36
 Identities = 128/399 (32%), Positives = 174/399 (43%), Gaps = 51/399 (12%)

Query: 186 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 245
           PDA F GL  L +L + G+    L   +FS L  L +L L+ N L A+   +F  L  L+
Sbjct: 90  PDA-FGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALE 148

Query: 246 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 305
            L+L  N + A+    F  L  L+ L+L+ N +A L E+ F  L  L+ L+LS+NA++ L
Sbjct: 149 SLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGL 208

Query: 306 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 365
               F  L  L+EL L  N I +L  + F  L  LE L L  N +  +    F  L N+ 
Sbjct: 209 PQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLT 268

Query: 366 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 425
            ++L  N LR LP  +F     L  L L  + L  +   TF  LS LR L L  N +  +
Sbjct: 269 FLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHL 328

Query: 426 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF 485
                  L EL++L L SN LT L   LFQ L KLE L LS+N+L  LP           
Sbjct: 329 PAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGI-------- 380

Query: 486 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK 545
             D ++N                                   L  L L GNPW C C L 
Sbjct: 381 -FDTNYN-----------------------------------LFNLALHGNPWQCDCHLA 404

Query: 546 ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCA 584
            L ++  Q    +   +Q  C G     PAY    +  A
Sbjct: 405 YLFNWLQQYTDRLLN-IQTYCAG-----PAYLKGQVVPA 437


>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
          Length = 512

 Score =  155 bits (393), Expect = 8e-38
 Identities = 170/531 (32%), Positives = 219/531 (41%), Gaps = 105/531 (19%)

Query: 3   LRKGGLAL-ALLLLSWVALGPRSLEGA-DPGTP--GEAEGP---ACPAACVCSYDDDADE 55
           + + GLA+   LLL  +  GP  + G  D   P  GE+  P   ACP  C C   D  D 
Sbjct: 1   MAESGLAMWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD- 59

Query: 56  LSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS--L 113
               C   +L   PD +    Q L L  N L  +P      LS L  LNL    + S  L
Sbjct: 60  ----CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGL 115

Query: 114 EPQALLGLENLCHLHLERNQL--------RSLALG-------------TFAHTPALASLG 152
             +A   L  L HL +  N+L        RSL +              TF   PAL S+ 
Sbjct: 116 PDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVY 175

Query: 153 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA 212
           L NN+LS                       A LP  AFRG  ++  L L+ N+L+YL P+
Sbjct: 176 LHNNQLSN----------------------AGLPPDAFRGSEAIATLSLSNNQLSYLPPS 213

Query: 213 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 272
           L                            P L++L+L  NLI+ V  GA      LR L 
Sbjct: 214 L---------------------------PPSLERLHLQNNLISKVPRGALSRQTQLRELY 246

Query: 273 LSHNRV--AGLLEDTFPGLLGLRVLRLSHNAIASL---RPRTFKDLHFLEELQLGHNRIR 327
           L HN++  +GL   TF  L  L  L LSHN + ++    PRT   LH      LG NRIR
Sbjct: 247 LQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH------LGRNRIR 300

Query: 328 QLAERSFEGLGQLEVLTLDHNQL--QEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGL 385
           Q+      G   L  L L HNQL    + AGA   L  +  ++L GN L  +P  + R L
Sbjct: 301 QVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRL 360

Query: 386 GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG--IEEQSLWGLAELLELDLTS 443
             L   H   + LG           GL  L L  N L    +  ++   L  L  LDL  
Sbjct: 361 RALVLPHNHVAALG---ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAG 417

Query: 444 NQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
           NQLT LP  L  GL  L+   L RN+L  L  + L  L +   L ++HNRL
Sbjct: 418 NQLTRLPMGLPTGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRL 465



 Score =  103 bits (258), Expect = 3e-22
 Identities = 99/274 (36%), Positives = 126/274 (45%), Gaps = 17/274 (6%)

Query: 61  SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQL--GSLEPQAL 118
           S+  L+ LP  +P   + L L  N +S VP  A    + L  L LQ  QL    L+    
Sbjct: 203 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 262

Query: 119 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 178
             L +L +L L  NQL ++  G       LA L L  NR+ ++E     G   L  L L 
Sbjct: 263 SKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQ 319

Query: 179 WNSLAV--LPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKAN 236
            N L    LP  A R L  L  L L GN L  + PAL      LR L L  N + A+ A 
Sbjct: 320 HNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGAR 376

Query: 237 VFVQLPRLQKLYLDRNLIAA--VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL-LGLR 293
             V  P L +L L  N +A+  V   AF  L+ALR LDL+ N++  L      GL  GLR
Sbjct: 377 DLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPM----GLPTGLR 432

Query: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
            L+L  N +  L P     L  L EL L HNR+R
Sbjct: 433 TLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 466



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 11/178 (6%)

Query: 364 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 423
           V  ++  G  LR  P+ + R       L L+ + L  +  +  + LSGLR L L +N + 
Sbjct: 55  VDTVDCDGLDLRVFPDNITRAA---QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLIS 111

Query: 424 --GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALG-- 479
             G+ +++   L +L  L +  N+L+  P  L + L   +   L+ N++ E+     G  
Sbjct: 112 SEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVAD---LAANQVMEIFPLTFGEK 168

Query: 480 PLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-PPGLERLWLEGN 536
           P  R+ +L  +      LP         +  LSL NN L    P  PP LERL L+ N
Sbjct: 169 PALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 226


>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
          Length = 510

 Score =  154 bits (390), Expect = 2e-37
 Identities = 167/520 (32%), Positives = 213/520 (40%), Gaps = 104/520 (20%)

Query: 13  LLLSWVALGPRSLEGA-DPGTP--GEAEGP---ACPAACVCSYDDDADELSVFCSSRNLT 66
           LLL  +  GP  + G  D   P  GE+  P   ACP  C C   D  D     C   +L 
Sbjct: 10  LLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD-----CDGLDLR 64

Query: 67  RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQALLGLENL 124
             PD +    Q L L  N L  +P      LS L  LNL    + S  L  +A   L  L
Sbjct: 65  VFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQL 124

Query: 125 CHLHLERNQL--------RSLALG-------------TFAHTPALASLGLSNNRLSRLED 163
            HL +  N+L        RSL +              TF   PAL S+ L NN+LS    
Sbjct: 125 QHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSN--- 181

Query: 164 GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELREL 223
                              A LP  AFRG  ++  L L+ N+L+YL P+L          
Sbjct: 182 -------------------AGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---------- 212

Query: 224 DLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV--AGL 281
                             P L++L+L  NLI+ V  GA      LR L L HN++  +GL
Sbjct: 213 -----------------PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGL 255

Query: 282 LEDTFPGLLGLRVLRLSHNAIASL---RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 338
              TF  L  L  L LSHN + ++    PRT   LH      LG NRIRQ+      G  
Sbjct: 256 DATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH------LGRNRIRQVEAARLHGAR 309

Query: 339 QLEVLTLDHNQL--QEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS 396
            L  L L HNQL    + AGA   L  +  ++L GN L  +P  + R L  L   H   +
Sbjct: 310 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVA 369

Query: 397 CLGRIRPHTFTGLSGLRRLFLKDNGLVG--IEEQSLWGLAELLELDLTSNQLTHLPHRLF 454
            LG           GL  L L  N L    +  ++   L  L  LDL  NQLT LP  L 
Sbjct: 370 ALG---ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP 426

Query: 455 QGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
            GL  L+   L RN+L  L  + L  L +   L ++HNRL
Sbjct: 427 TGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRL 463



 Score =  103 bits (258), Expect = 3e-22
 Identities = 99/274 (36%), Positives = 126/274 (45%), Gaps = 17/274 (6%)

Query: 61  SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQL--GSLEPQAL 118
           S+  L+ LP  +P   + L L  N +S VP  A    + L  L LQ  QL    L+    
Sbjct: 201 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 260

Query: 119 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 178
             L +L +L L  NQL ++  G       LA L L  NR+ ++E     G   L  L L 
Sbjct: 261 SKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQ 317

Query: 179 WNSLAV--LPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKAN 236
            N L    LP  A R L  L  L L GN L  + PAL      LR L L  N + A+ A 
Sbjct: 318 HNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGAR 374

Query: 237 VFVQLPRLQKLYLDRNLIAA--VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL-LGLR 293
             V  P L +L L  N +A+  V   AF  L+ALR LDL+ N++  L      GL  GLR
Sbjct: 375 DLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPM----GLPTGLR 430

Query: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
            L+L  N +  L P     L  L EL L HNR+R
Sbjct: 431 TLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 464



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 11/178 (6%)

Query: 364 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 423
           V  ++  G  LR  P+ + R       L L+ + L  +  +  + LSGLR L L +N + 
Sbjct: 53  VDTVDCDGLDLRVFPDNITRAA---QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLIS 109

Query: 424 --GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALG-- 479
             G+ +++   L +L  L +  N+L+  P  L + L   +   L+ N++ E+     G  
Sbjct: 110 SEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVAD---LAANQVMEIFPLTFGEK 166

Query: 480 PLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-PPGLERLWLEGN 536
           P  R+ +L  +      LP         +  LSL NN L    P  PP LERL L+ N
Sbjct: 167 PALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 224


>gi|62912472 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 2 [Homo sapiens]
          Length = 915

 Score =  152 bits (384), Expect = 9e-37
 Identities = 118/350 (33%), Positives = 173/350 (49%), Gaps = 6/350 (1%)

Query: 176 NLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKA 235
           +L  N+L  L    F  L  L EL L+GN L+++    FSGL  L+ L L  N L  I A
Sbjct: 20  DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79

Query: 236 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 295
               +LP LQ L LD NLI+ V   +F GL +LR L L  N +  +       L  L+ +
Sbjct: 80  EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139

Query: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 355
            L+ N I+ +    F++L  L  L L +NRI+ L   SFEGL  LE L L++N+LQE   
Sbjct: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199

Query: 356 GAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRL 415
            A   L  +  +    N ++ +PE+ F G   L ++H   + +  +    F  L  L  L
Sbjct: 200 -AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 258

Query: 416 FLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELP 474
            L  NG + I+E   L G   L  L LT   +  LP  + Q L +L  L LS N++ ELP
Sbjct: 259 SL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 316

Query: 475 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 524
             +L   Q+   + + HNR+  +     + L  L+ L L  N++R+  P+
Sbjct: 317 --SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364



 Score =  147 bits (371), Expect = 3e-35
 Identities = 121/392 (30%), Positives = 189/392 (48%), Gaps = 9/392 (2%)

Query: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 207
           +++  LS N L+ L+ GLF  L  L +L L  N L+ +P  AF GL SL+ L+L  N+L 
Sbjct: 16  ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75

Query: 208 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 267
            +       L  L+ L L  N +  +    F  L  L+ L+LD N +  +   A   L A
Sbjct: 76  GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135

Query: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
           L+ + L+ NR++ + +  F  L  L VL L +N I  L   +F+ LH LE L L +N+++
Sbjct: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195

Query: 328 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 387
           +    +   LG+L+ L   +N ++ +   AF+G   +  ++   N ++ +    F+ L K
Sbjct: 196 EFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPK 254

Query: 388 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 447
           LH+L L G+   +  P    G + L  L L   G+  +       L  L  L+L+ NQ+ 
Sbjct: 255 LHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE 313

Query: 448 HLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPL 505
            LP  HR      KLE + L  NR+ E+ AD    L     LD+S N + ++     + L
Sbjct: 314 ELPSLHR----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 369

Query: 506 GRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 536
             L  L L +N L T       GL  L L+GN
Sbjct: 370 HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 401



 Score =  138 bits (348), Expect = 1e-32
 Identities = 125/389 (32%), Positives = 178/389 (45%), Gaps = 9/389 (2%)

Query: 129 LERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA 188
           L  N L  L  G F H   L  L LS N LS +    F GL SL  L L  N L  +P  
Sbjct: 21  LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80

Query: 189 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 248
           A   L SL+ L L  N ++ +    F GL+ LR L L  NAL  I       LP LQ + 
Sbjct: 81  ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140

Query: 249 LDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 308
           L  N I+ +   AF  L +L  L L +NR+  L   +F GL  L  L L++N +    P 
Sbjct: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PV 199

Query: 309 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMN 368
             + L  L+EL   +N I+ + E++F G   L+ +    N +Q V   AF  L  +  ++
Sbjct: 200 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259

Query: 369 LSGNC-LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 427
           L+G   ++  P+   +G   L  L L  + +  +       L  LR L L  N +   E 
Sbjct: 260 LNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE--EL 315

Query: 428 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 487
            SL    +L E+ L  N++  +    F  L  L+ L LS N +  +  +A   L     L
Sbjct: 316 PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 375

Query: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 516
           D++ N+L  LP   LA LG L +L L+ N
Sbjct: 376 DLTDNQLTTLP---LAGLGGLMHLKLKGN 401



 Score =  137 bits (345), Expect = 3e-32
 Identities = 130/413 (31%), Positives = 185/413 (44%), Gaps = 46/413 (11%)

Query: 39  PACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGT---QALWLDGNNLSSVPPAAFQ 95
           P     C  S    A +LS+     NLT L  G+       + L L GN+LS +P  AF 
Sbjct: 4   PRLTLVCQVSIIISARDLSM----NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFS 59

Query: 96  NLSSLGFLNLQGGQLGSLEPQALL------------------------GLENLCHLHLER 131
            L SL  L LQ  QLG +  +AL                         GL +L HL L+ 
Sbjct: 60  GLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDD 119

Query: 132 NQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFR 191
           N L  + +    + PAL ++ L+ NR+S + D  F+ L SL  L+L  N +  L   +F 
Sbjct: 120 NALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE 179

Query: 192 GLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR 251
           GL +L  L L  N+L    P     L  L+EL    N ++AI    F+  P LQ ++   
Sbjct: 180 GLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYD 238

Query: 252 NLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE-DTFPGLLG---LRVLRLSHNAIASLRP 307
           N I  V   AF  L  L  L L+     G ++   FP L G   L +L L+   I  L  
Sbjct: 239 NPIQFVGRSAFQYLPKLHTLSLN-----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS 293

Query: 308 RTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVM 367
              + L  L  L+L HN+I +L   S     +LE + L HN++ E+ A  F  L+++  +
Sbjct: 294 GMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 351

Query: 368 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
           +LS N +R++  + F  L  L  L L  + L  +      GL GL  L LK N
Sbjct: 352 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 401


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  150 bits (380), Expect = 2e-36
 Identities = 122/367 (33%), Positives = 173/367 (47%), Gaps = 10/367 (2%)

Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
           L+L  N+++ L       L  L EL LAGN L Y+    F+GL  L+ L L  N LR + 
Sbjct: 71  LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130

Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
                 L  LQ L LD N I+ V P  F GL +LR L L  N +  +    F  L  L+ 
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190

Query: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
           + L+ N I  +    F +L  L  L L +NRI  L ++ F+GL  LE L L++N L E  
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250

Query: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 414
             A   L+N+  +    N +R++PE+ F G   L ++H   + +  +    F  L  LR 
Sbjct: 251 T-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309

Query: 415 LFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAEL 473
           L L  NG   I E   L G A L  L LT  Q++ LP  +   L  L+ L LS N L +L
Sbjct: 310 LTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL 367

Query: 474 PADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLE 529
           P+ ++   Q+   +D+ HN +  +       L  LR L+L  N +    P      P L 
Sbjct: 368 PSFSV--CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLI 425

Query: 530 RLWLEGN 536
           +L L  N
Sbjct: 426 KLDLSSN 432



 Score =  148 bits (373), Expect = 2e-35
 Identities = 145/463 (31%), Positives = 205/463 (44%), Gaps = 17/463 (3%)

Query: 7   GLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLT 66
           G+ L+L +L  +A G     G+ P +     G  CP  C C   D    L V CS   L+
Sbjct: 7   GVLLSLPVLLQLATG-----GSSPRSGVLLRG--CPTHCHCE-PDGRMLLRVDCSDLGLS 58

Query: 67  RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCH 126
            LP  +   T  L L  NN+S + P    +L  L  L L G  L  +   A  GL +L  
Sbjct: 59  ELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKV 118

Query: 127 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 186
           L L+ NQLR +      +  +L SL L  N +S +    F GL SL  L L  N+L  +P
Sbjct: 119 LMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIP 178

Query: 187 DAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQK 246
             AFR L +L+ + LA N++ ++    F  L+ L  L L  N + ++    F  L  L+ 
Sbjct: 179 VQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLET 238

Query: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 306
           L L+ N +    P A   L  L+ L    N +  + E  F G   L  +    N I  + 
Sbjct: 239 LDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVG 297

Query: 307 PRTFKDLHFLEELQLGHNRIRQLAE-RSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 365
              F+ L  L  L L  N   Q+ E     G   LE LTL   Q+  +       L N+ 
Sbjct: 298 RSAFQHLPELRTLTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQ 355

Query: 366 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 425
           V++LS N L +LP   F    KL  + L  + +  I+  TF  L  LR L L  N +  I
Sbjct: 356 VLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII 413

Query: 426 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468
              +   L  L++LDL+SN L+  P     GL  L +L L+ N
Sbjct: 414 HPNAFSTLPSLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGN 453



 Score =  106 bits (264), Expect = 7e-23
 Identities = 68/206 (33%), Positives = 100/206 (48%), Gaps = 1/206 (0%)

Query: 315 FLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
           F   L L  N I QL       L  LE L L  N L  +  GAF GL ++ V+ L  N L
Sbjct: 67  FTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQL 126

Query: 375 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 434
           R++P +  + L  L SL L+ + +  + P  F+GL  LR L+L DN L  I  Q+   L+
Sbjct: 127 RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS 186

Query: 435 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
            L  + L  N++ H+P   F  L  L  L L  NR+  L       L     LD+++N L
Sbjct: 187 ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246

Query: 495 EALPNSLLAPLGRLRYLSLRNNSLRT 520
           +  P + +  L  L+ L   +N++R+
Sbjct: 247 DEFPTA-IRTLSNLKELGFHSNNIRS 271



 Score =  100 bits (250), Expect = 3e-21
 Identities = 81/269 (30%), Positives = 122/269 (45%), Gaps = 4/269 (1%)

Query: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 329
           +LDLS N ++ LL +  P L  L  LRL+ NA+  +    F  L+ L+ L L +N++R +
Sbjct: 70  YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129

Query: 330 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 389
              + + L  L+ L LD N +  V    F GL ++  + L  N L  +P Q FR L  L 
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189

Query: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
           ++ L  + +  I  + F  LS L  L L +N +  + ++   GL  L  LDL  N L   
Sbjct: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249

Query: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 509
           P  + + L  L+ L    N +  +P  A         +    N ++ +  S    L  LR
Sbjct: 250 PTAI-RTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELR 308

Query: 510 YLSLRNNSLRTFTPQPPG---LERLWLEG 535
            L+L   S  T  P   G   LE L L G
Sbjct: 309 TLTLNGASQITEFPDLTGTANLESLTLTG 337


>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
          Length = 1032

 Score =  147 bits (371), Expect = 3e-35
 Identities = 178/617 (28%), Positives = 251/617 (40%), Gaps = 111/617 (17%)

Query: 64  NLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLEN 123
           NLT +P  +P   + L L  N +  + P    NL++L  L++ GG     +      +E 
Sbjct: 210 NLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDV-GGNCRRCDHAPNPCME- 267

Query: 124 LCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL- 182
            C  H  +     L   TF+H   L  L L ++ LS L    F GLG+L  L+L  N L 
Sbjct: 268 -CPRHFPQ-----LHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLY 321

Query: 183 -AVLPDAAFRGLGSLRELVLAGN---RLAYLQPAL---FSGLAELRELDLSRNALRAIKA 235
             +    AF+GL  LR+L L+ N   R+++   +L   F  L  L+ELD+     R++  
Sbjct: 322 KCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDE 381

Query: 236 NVF---VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTF------ 286
                  +LP LQ L L  N I     G F     LR++DLS NR++G  E T       
Sbjct: 382 TTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEAD 441

Query: 287 --------PGLLGLR-------------------VLRLSHNAIASLRPRTFKDLHFLEEL 319
                   PG L                       L LS N + +++P  F  L  L+ L
Sbjct: 442 GGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCL 501

Query: 320 QLGHNRIRQLAERS-FEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN------ 372
           +L HN I Q    S F  L  L+VL L HN+L      +F  L  +  ++LS N      
Sbjct: 502 RLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGM 561

Query: 373 ---------------------CLRNLPEQVFRGL--GKLHSLHLEGSCLGR------IRP 403
                                   N+  QV + L    L +L   G+ LG       +  
Sbjct: 562 QGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYL 621

Query: 404 HTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLE-LDLTSNQLTHLPHRLFQGLGKLEY 462
           H F GLSGL  L L  N L  +  Q+L  L + L+ L L  N L          L KLE 
Sbjct: 622 HFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEV 681

Query: 463 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRT-- 520
           L L+ N+L  L   +L    R   LDVS N +  +     +    LR L+L  N+L+T  
Sbjct: 682 LDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVD 741

Query: 521 ---FTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYT 577
              F P    L+ L +  NP  C C   A  DF L+  +AVP                  
Sbjct: 742 HSWFGPLASALQILDVSANPLHCACG-AAFMDFLLEVQAAVPGLP--------------- 785

Query: 578 YNNITCASPPEVVGLDL 594
            + + C SP ++ GL +
Sbjct: 786 -SRVKCGSPGQLQGLSI 801



 Score =  103 bits (258), Expect = 3e-22
 Identities = 144/545 (26%), Positives = 205/545 (37%), Gaps = 139/545 (25%)

Query: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAV------------LPDAAFRGLGS 195
           + SL LS+NR+  L D  F  L SL  LNL WN   V            +  + F  + +
Sbjct: 65  VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPT 124

Query: 196 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL-- 253
           L EL L+ N +  + PAL   L     L LS   +  + +     L  L+ L++D N   
Sbjct: 125 LEELNLSYNNIMTV-PALPKSLI---SLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180

Query: 254 ------IAAVAPGAFLGL---------------------KALRWLDLSHNRVAGLLEDTF 286
                    VAPGA LGL                      +L +L LS+NR+  L  +  
Sbjct: 181 KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL 240

Query: 287 PGLLGLRVLRLSHNA----------------IASLRPRTFKDLHFLEELQLGHNRIRQLA 330
             L  LRVL +  N                    L P TF  L  LE L L  + +  L 
Sbjct: 241 ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN 300

Query: 331 ERSFEGLGQLEVLTLDHNQLQE--VKAGAFLGLTNVAVMNLS------------------ 370
              F GLG L VL L  N L +   K  AF GLT +  +NLS                  
Sbjct: 301 ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF 360

Query: 371 ------------GNCLRNLPEQVFRGLGK---LHSLHLEGSCLGRIRPHTFTGLSGLRRL 415
                       G   R+L E   R L +   L +L L+ + + + +   F    GLR +
Sbjct: 361 GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420

Query: 416 FLKDNGLVGIEE-----------QSLW----GLAEL------------------LELDLT 442
            L DN + G  E           + +W     LA                      LDL+
Sbjct: 421 DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS 480

Query: 443 SNQLTHLPHRLFQGLGKLEYLLLSRNRLAE-LPADALGPLQRAFWLDVSHNRLEALPNSL 501
            N L  +   +F  L  L+ L LS N +++ +      PL     LD+SHN+L+      
Sbjct: 481 RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS 540

Query: 502 LAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRF 561
              L RL  L L  NS      QP G++ +   G+ +     L+ LR  +L + +   + 
Sbjct: 541 FTELPRLEALDLSYNS------QPFGMQGV---GHNFSFVAHLRTLRHLSLAHNNIHSQV 591

Query: 562 VQAIC 566
            Q +C
Sbjct: 592 SQQLC 596



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 53/201 (26%), Positives = 79/201 (39%), Gaps = 35/201 (17%)

Query: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 397
           G +  L+L  N++  +    F  L ++  +NL  NC    P     GL  +H       C
Sbjct: 63  GNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNC----PPV---GLSPMHF-----PC 110

Query: 398 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 457
              I P TF  +  L  L L  N ++ +          L+ L L+   +  L      GL
Sbjct: 111 HMTIEPSTFLAVPTLEELNLSYNNIMTVPALP----KSLISLSLSHTNILMLDSASLAGL 166

Query: 458 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 517
             L +L +  N                ++ +     LE  P +LL  LG L +LSL+ N+
Sbjct: 167 HALRFLFMDGN---------------CYYKNPCRQALEVAPGALLG-LGNLTHLSLKYNN 210

Query: 518 LRTFTPQ--PPGLERLWLEGN 536
           L T  P+  P  LE L L  N
Sbjct: 211 L-TVVPRNLPSSLEYLLLSYN 230


>gi|193083139 leucine rich repeat containing 32 precursor [Homo
           sapiens]
          Length = 662

 Score =  146 bits (368), Expect = 6e-35
 Identities = 172/558 (30%), Positives = 234/558 (41%), Gaps = 90/558 (16%)

Query: 58  VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 117
           V C    L ++P  +P  T+ L L GN L S+  +     ++L  L+L   ++  L+P A
Sbjct: 33  VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 92

Query: 118 LLGLENLCHLHLERNQL---RSLALGTFAHTPALASLGLSNNRL-SRLEDGLFEGLGSLW 173
              L +L HL L  N+L    +L+ G     P + SL LS N L S L + L     SL 
Sbjct: 93  FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152

Query: 174 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 233
            L+L  NSL  L    FR + +L +L L  N L  ++   F GL  L  L+LSRN+L  I
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212

Query: 234 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLK-ALRWLDLSHNRVAGLLEDTFPGLLGL 292
                  L +L+ L L  N I A    +    +  L WLDL  N++       FP L  L
Sbjct: 213 SD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLL-----HFPDLAAL 264

Query: 293 R---VLRLSHNAI--ASLRPRTFKDLH--------------------------------- 314
                L LS+N I   +  P+  K +H                                 
Sbjct: 265 PRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324

Query: 315 ---------FLEE------LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFL 359
                    FLE       L L  N +R    R    L  L +L L HN L+ ++ GA  
Sbjct: 325 NEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-R 383

Query: 360 GLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS----CLGRIRPH-----TFTGLS 410
            L ++  + L GN LR+LP   F  L  L  L+L+G+    C G   P       F+G++
Sbjct: 384 ALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGIT 443

Query: 411 GLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL-GKLEYLLLSRNR 469
            LR L L DN  + +     +    L ELDL+SN    +      GL   LE L L  N 
Sbjct: 444 SLRSLSLVDNE-IELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNG 502

Query: 470 LAELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG 527
           L  L  D      L+R   L+++ NRL  LP    A    L  L LRNNS         G
Sbjct: 503 LMVLQVDLPCFICLKR---LNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLPGSAMG 557

Query: 528 -----LERLWLEGNPWDC 540
                L RL+L+GNP  C
Sbjct: 558 GLETSLRRLYLQGNPLSC 575



 Score =  100 bits (248), Expect = 5e-21
 Identities = 90/278 (32%), Positives = 124/278 (44%), Gaps = 29/278 (10%)

Query: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330
           LDLS N++  +L         LR L LS N I+ L+P  F+ L  LE L L HNR+    
Sbjct: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113

Query: 331 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-RNLPEQVFRGLGKLH 389
             S  GLG                      L  V  ++LSGN L   L E++      LH
Sbjct: 114 ALSAGGLGP---------------------LPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152

Query: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
           +L L  + L R+  HTF  +  L +L L  N L+ IE+ +  GL  L  L+L+ N LT +
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212

Query: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-RAFWLDVSHNRLEALPNSLLAPLGRL 508
                Q   +L  L LS N +      +    + +  WLD+  N+L   P+  LA L RL
Sbjct: 213 SDFSLQ---QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRL 267

Query: 509 RYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 546
            YL+L NN +R  T  P   + +      W    PL A
Sbjct: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS-ALPLSA 304


>gi|5031707 leucine rich repeat containing 32 precursor [Homo
           sapiens]
          Length = 662

 Score =  146 bits (368), Expect = 6e-35
 Identities = 172/558 (30%), Positives = 234/558 (41%), Gaps = 90/558 (16%)

Query: 58  VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 117
           V C    L ++P  +P  T+ L L GN L S+  +     ++L  L+L   ++  L+P A
Sbjct: 33  VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 92

Query: 118 LLGLENLCHLHLERNQL---RSLALGTFAHTPALASLGLSNNRL-SRLEDGLFEGLGSLW 173
              L +L HL L  N+L    +L+ G     P + SL LS N L S L + L     SL 
Sbjct: 93  FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152

Query: 174 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 233
            L+L  NSL  L    FR + +L +L L  N L  ++   F GL  L  L+LSRN+L  I
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212

Query: 234 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLK-ALRWLDLSHNRVAGLLEDTFPGLLGL 292
                  L +L+ L L  N I A    +    +  L WLDL  N++       FP L  L
Sbjct: 213 SD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLL-----HFPDLAAL 264

Query: 293 R---VLRLSHNAI--ASLRPRTFKDLH--------------------------------- 314
                L LS+N I   +  P+  K +H                                 
Sbjct: 265 PRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324

Query: 315 ---------FLEE------LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFL 359
                    FLE       L L  N +R    R    L  L +L L HN L+ ++ GA  
Sbjct: 325 NEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-R 383

Query: 360 GLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS----CLGRIRPH-----TFTGLS 410
            L ++  + L GN LR+LP   F  L  L  L+L+G+    C G   P       F+G++
Sbjct: 384 ALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGIT 443

Query: 411 GLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL-GKLEYLLLSRNR 469
            LR L L DN  + +     +    L ELDL+SN    +      GL   LE L L  N 
Sbjct: 444 SLRSLSLVDNE-IELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNG 502

Query: 470 LAELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG 527
           L  L  D      L+R   L+++ NRL  LP    A    L  L LRNNS         G
Sbjct: 503 LMVLQVDLPCFICLKR---LNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLPGSAMG 557

Query: 528 -----LERLWLEGNPWDC 540
                L RL+L+GNP  C
Sbjct: 558 GLETSLRRLYLQGNPLSC 575



 Score =  100 bits (248), Expect = 5e-21
 Identities = 90/278 (32%), Positives = 124/278 (44%), Gaps = 29/278 (10%)

Query: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330
           LDLS N++  +L         LR L LS N I+ L+P  F+ L  LE L L HNR+    
Sbjct: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113

Query: 331 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-RNLPEQVFRGLGKLH 389
             S  GLG                      L  V  ++LSGN L   L E++      LH
Sbjct: 114 ALSAGGLGP---------------------LPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152

Query: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
           +L L  + L R+  HTF  +  L +L L  N L+ IE+ +  GL  L  L+L+ N LT +
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212

Query: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-RAFWLDVSHNRLEALPNSLLAPLGRL 508
                Q   +L  L LS N +      +    + +  WLD+  N+L   P+  LA L RL
Sbjct: 213 SDFSLQ---QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRL 267

Query: 509 RYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 546
            YL+L NN +R  T  P   + +      W    PL A
Sbjct: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS-ALPLSA 304


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score =  145 bits (365), Expect = 1e-34
 Identities = 112/346 (32%), Positives = 160/346 (46%), Gaps = 8/346 (2%)

Query: 30  PGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 89
           P  P  A G  CPA C C+    A    V C+ R LT +PDG+P  T+ L L  N +  +
Sbjct: 16  PAAPPPAGG--CPARCECTVQTRA----VACTRRRLTAVPDGIPAETRLLELSRNRIRCL 69

Query: 90  PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 149
            P     L +L  L+L    +  +EP A   L  L  L L  NQL+ +  G F     L 
Sbjct: 70  NPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLT 129

Query: 150 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 209
            L LS N+L  L D  F+ L SL  L +G N L  +   AF GL +L EL L    L  L
Sbjct: 130 LLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTAL 189

Query: 210 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR-NLIAAVAPGAFLGLKAL 268
                  L  L  L L   A+ +++   F +LP L  L +D   L+  VA G+  GL  L
Sbjct: 190 SGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-L 248

Query: 269 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 328
             L ++H  +  +          L  L LSHN I+++   +F+DL  L EL L    +  
Sbjct: 249 TSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAV 308

Query: 329 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
           +  ++F GL Q+ +L L +N L  ++   F  +  +  + + GN L
Sbjct: 309 VEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPL 354



 Score =  120 bits (302), Expect = 3e-27
 Identities = 115/384 (29%), Positives = 176/384 (45%), Gaps = 42/384 (10%)

Query: 218 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 277
           AE R L+LSRN +R +       LP L++L L  N IA V PGAF  L  LR L L  N+
Sbjct: 54  AETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQ 113

Query: 278 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 337
           +  +    F  L  L +L LS N +  L   TF+DLH L  L++G N +  ++ R+F GL
Sbjct: 114 LKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGL 173

Query: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEG-S 396
             LE LTL+   L  +   +   L ++  + L    + +L +Q FR L  L  L ++   
Sbjct: 174 LALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWP 233

Query: 397 CLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQG 456
            L  +   +  GL+ L  L +    +  +   +L   A L  L+L+ N ++ +P   F+ 
Sbjct: 234 LLEEVAAGSLRGLN-LTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRD 292

Query: 457 LGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNN 516
           L +L  L L+   LA +   A   L++   L++S+N L  L  S               +
Sbjct: 293 LVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTF-------------H 339

Query: 517 SLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAY 576
           S+ T       LE L ++GNP  C C L     + +Q    +           D + PA 
Sbjct: 340 SVNT-------LETLRVDGNPLACDCRLL----WIVQRRKTL---------NFDGRLPA- 378

Query: 577 TYNNITCASPPEVVGLDLRDLSEA 600
                 CA+P EV G  LR+L ++
Sbjct: 379 ------CATPAEVRGDALRNLPDS 396



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 56/179 (31%), Positives = 89/179 (49%)

Query: 77  QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 136
           + L L+  NL+++   +  +L SLG L L+   + SLE Q    L  L HL ++   L  
Sbjct: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236

Query: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196
                      L SL +++  ++ +          L  LNL  N ++ +P  +FR L  L
Sbjct: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296

Query: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 255
           REL LAG  LA ++P  F GL ++R L+LS N L  ++ + F  +  L+ L +D N +A
Sbjct: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA 355


>gi|4507531 toll-like receptor 3 [Homo sapiens]
          Length = 904

 Score =  144 bits (363), Expect = 2e-34
 Identities = 145/526 (27%), Positives = 236/526 (44%), Gaps = 59/526 (11%)

Query: 60  CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119
           CS   LT++PD +P     L L  N L  +P A F   S L  L++    +  LEP+   
Sbjct: 37  CSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQ 96

Query: 120 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 179
            L  L  L+L+ N+L  L+  TFA    L  L L +N + ++++  F    +L  L+L  
Sbjct: 97  KLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSH 156

Query: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA---LFSGLAELRELDLSRNALRAIKAN 236
           N L+         L +L+EL+L+ N++  L+     +F+  + L++L+LS N ++     
Sbjct: 157 NGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN-SSLKKLELSSNQIKEFSPG 215

Query: 237 VFVQLPRLQKLYLD---------------------RNL------IAAVAPGAFLGLK--A 267
            F  + RL  L+L+                     RNL      ++  +   FLGLK   
Sbjct: 216 CFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTN 275

Query: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
           L  LDLS+N +  +  D+F  L  L    L +N I  L   +   L  +  L L  +  +
Sbjct: 276 LTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTK 335

Query: 328 Q---------LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN--CLRN 376
           Q         + + SF+ L  LE L ++ N +  +K+  F GL N+  ++LS +   LR 
Sbjct: 336 QSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRT 395

Query: 377 LPEQVFRGL--GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL-VGIEEQSLWGL 433
           L  + F  L    LH L+L  + + +I    F+ L  L  L L  N +   +  Q   GL
Sbjct: 396 LTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGL 455

Query: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPA--DALGPLQRAFWLDVSH 491
             + E+ L+ N+   L    F  +  L+ L+L R  L  + +      PL+    LD+S+
Sbjct: 456 ENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSN 515

Query: 492 NRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNP 537
           N +  + + +L  L +L  L L++N+          L RLW   NP
Sbjct: 516 NNIANINDDMLEGLEKLEILDLQHNN----------LARLWKHANP 551



 Score =  141 bits (356), Expect = 2e-33
 Identities = 154/553 (27%), Positives = 234/553 (42%), Gaps = 79/553 (14%)

Query: 53  ADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS 112
           +D+   FC+  NLT L            L  N++  +    F    +L  L+L    L S
Sbjct: 115 SDKTFAFCT--NLTELH-----------LMSNSIQKIKNNPFVKQKNLITLDLSHNGLSS 161

Query: 113 LEPQALLGLENLCHLHLERNQLRSLA---LGTFAHTPALASLGLSNNRLSRLEDGLFEGL 169
            +    + LENL  L L  N++++L    L  FA++ +L  L LS+N++     G F  +
Sbjct: 162 TKLGTQVQLENLQELLLSNNKIQALKSEELDIFANS-SLKKLELSSNQIKEFSPGCFHAI 220

Query: 170 GSLWDLNLGWNSLAVLPDAAFR-----GLGSLRELVLAGNRLAYLQPALFSGL--AELRE 222
           G L+ L L  N++ + P    +        S+R L L+ ++L+      F GL    L  
Sbjct: 221 GRLFGLFL--NNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTM 278

Query: 223 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA--------------------------- 255
           LDLS N L  +  + F  LP+L+  +L+ N I                            
Sbjct: 279 LDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSI 338

Query: 256 ------AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN--AIASLRP 307
                  +   +F  LK L  L++  N + G+  + F GL+ L+ L LS++  ++ +L  
Sbjct: 339 SLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTN 398

Query: 308 RTFKDLHF--LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL-QEVKAGAFLGLTNV 364
            TF  L    L  L L  N+I ++   +F  LG LEVL L  N++ QE+    + GL N+
Sbjct: 399 ETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENI 458

Query: 365 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI--RPHTFTGLSGLRRLFLKDNGL 422
             + LS N    L    F  +  L  L L    L  +   P  F  L  L  L L +N +
Sbjct: 459 FEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNI 518

Query: 423 VGIEEQSLWGLAELLELDLTSNQLTHL--------PHRLFQGLGKLEYLLLSRNRLAELP 474
             I +  L GL +L  LDL  N L  L        P    +GL  L  L L  N   E+P
Sbjct: 519 ANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIP 578

Query: 475 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL-----RTFTPQPPGLE 529
            +    L     +D+  N L  LP S+      L+ L+L+ N +     + F P    L 
Sbjct: 579 VEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLT 638

Query: 530 RLWLEGNPWDCGC 542
            L +  NP+DC C
Sbjct: 639 ELDMRFNPFDCTC 651



 Score =  116 bits (290), Expect = 7e-26
 Identities = 122/429 (28%), Positives = 184/429 (42%), Gaps = 47/429 (10%)

Query: 98  SSLGFLNLQGGQLGSLEPQALLGLE--NLCHLHLERNQLRSLALGTFAHTPALASLGLSN 155
           +S+  L+L   QL +      LGL+  NL  L L  N L  +   +FA  P L    L  
Sbjct: 248 TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEY 307

Query: 156 NRLSRLEDGLFEGLGSLWDLNLGWN------SLAVLP---DAAFRGLGSLRELVLAGNRL 206
           N +  L      GL ++  LNL  +      SLA LP   D +F+ L  L  L +  N +
Sbjct: 308 NNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDI 367

Query: 207 AYLQPALFSGLAELRELDLSRN--ALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLG 264
             ++  +F+GL  L+ L LS +  +LR +    FV L                       
Sbjct: 368 PGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAH--------------------- 406

Query: 265 LKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS-LRPRTFKDLHFLEELQLGH 323
              L  L+L+ N+++ +  D F  L  L VL L  N I   L  + ++ L  + E+ L +
Sbjct: 407 -SPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSY 465

Query: 324 NRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGA--FLGLTNVAVMNLSGNCLRNLPEQV 381
           N+  QL   SF  +  L+ L L    L+ V +    F  L N+ +++LS N + N+ + +
Sbjct: 466 NKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDM 525

Query: 382 FRGLGKLHSLHLEGSCLGRIRPHT--------FTGLSGLRRLFLKDNGLVGIEEQSLWGL 433
             GL KL  L L+ + L R+  H           GLS L  L L+ NG   I  +    L
Sbjct: 526 LEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDL 585

Query: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW-LDVSHN 492
            EL  +DL  N L  LP  +F     L+ L L +N +  +     GP  R    LD+  N
Sbjct: 586 FELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFN 645

Query: 493 RLEALPNSL 501
             +    S+
Sbjct: 646 PFDCTCESI 654


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  142 bits (359), Expect = 7e-34
 Identities = 103/314 (32%), Positives = 155/314 (49%), Gaps = 1/314 (0%)

Query: 60  CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119
           C +  L+ +P   P  T  L+L GNN+S +  +    L SL  L L    +  + P+A +
Sbjct: 46  CRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFV 105

Query: 120 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 179
            L +L  L L  N ++ L  G F     L +L L  N++S +  G+F  L S+  LNL  
Sbjct: 106 QLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQR 165

Query: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 239
           N L VL    F G+ +LR L L+ N +  +  + F  L  L  L L  N L  + +N F 
Sbjct: 166 NRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFE 225

Query: 240 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 299
            L  L++L L  N I A+ P AF GL  L +L L ++R+  +  D F G+  L+ L LSH
Sbjct: 226 VLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSH 285

Query: 300 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG-QLEVLTLDHNQLQEVKAGAF 358
           N + +L   TF  L  L  L+L  NRI  +   +FE +G  L++L L  N L  +     
Sbjct: 286 NDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVL 345

Query: 359 LGLTNVAVMNLSGN 372
             L+++  +  + N
Sbjct: 346 KPLSSLIHLQANSN 359



 Score =  142 bits (358), Expect = 9e-34
 Identities = 111/374 (29%), Positives = 163/374 (43%), Gaps = 42/374 (11%)

Query: 223 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 282
           L L+ N +  I  +    L  L  LYLD + I  V P AF+ L+ L +L L++N +  L 
Sbjct: 65  LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124

Query: 283 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 342
              F GLL LR L L +N ++ +    F DL  ++ L L  NR+  L   +F G+  L +
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184

Query: 343 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 402
           L L +N +  +    F  L N+A + L  N L  +P   F  L  L  L L  + +  I+
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244

Query: 403 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 462
           P  F GL+ L  L LK++ +  +      G+  L  L L+ N L +L    F  L  L Y
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304

Query: 463 LLLSRNRLAELPADALGPLQRAF-WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTF 521
           L L RNR+  +  D    +  +   L++S N L AL   +L PL  L +L   +      
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANS------ 358

Query: 522 TPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNI 581
                         NPW+C C L  LRD+   +   +                     NI
Sbjct: 359 --------------NPWECNCKLLGLRDWLASSAITL---------------------NI 383

Query: 582 TCASPPEVVGLDLR 595
            C +PP + G  LR
Sbjct: 384 YCQNPPSMRGRALR 397



 Score =  135 bits (341), Expect = 8e-32
 Identities = 93/295 (31%), Positives = 151/295 (51%), Gaps = 1/295 (0%)

Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
           L L  N+++ + ++   GL SL  L L  + + Y+ P  F  L  L  L L+ N ++ + 
Sbjct: 65  LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124

Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
             +F  L  L+ LYL  N ++ V  G F  L ++++L+L  NR+  L   TF G++ LR+
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184

Query: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
           L LS+N I  +    F+ L  L  L LG N + ++   +FE L  L  L+L HN ++ ++
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244

Query: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 414
             AF GL N+  + L  + +RN+    F G+  L  L L  + L  +   TF+ L  L  
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304

Query: 415 LFLKDNGLVGIEEQSLWGL-AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468
           L L  N ++ I+  +   + A L  L+L+ N LT L  R+ + L  L +L  + N
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359



 Score =  134 bits (337), Expect = 2e-31
 Identities = 105/331 (31%), Positives = 155/331 (46%), Gaps = 4/331 (1%)

Query: 118 LLGLENLCHLHLERN-QLRSLALGTFAHT--PALASLGLSNNRLSRLEDGLFEGLGSLWD 174
           +LG  ++C L   R    R+L L +       +   L L+ N +S + +    GL SL  
Sbjct: 29  ILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVA 88

Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
           L L  +++  +   AF  L  L  L L  N +  L P +F GL  LR L L  N +  + 
Sbjct: 89  LYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVP 148

Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
             VF  L  +Q L L RN +  +  G F+G+ ALR LDLS+N +  + E  F  L  L  
Sbjct: 149 RGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLAC 208

Query: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
           L L  N +  +    F+ L  L  L L HN I  +   +F+GL  LE L L +++++ V 
Sbjct: 209 LYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVT 268

Query: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL-SGLR 413
              F G+ N+  + LS N L NL    F  L  L  L L+ + +  I   TF  + + L+
Sbjct: 269 RDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLK 328

Query: 414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSN 444
            L L  N L  +  + L  L+ L+ L   SN
Sbjct: 329 ILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score =  141 bits (356), Expect = 2e-33
 Identities = 122/350 (34%), Positives = 170/350 (48%), Gaps = 21/350 (6%)

Query: 33  PGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPA 92
           PG   G +CPA C C+    A    V C  R L  +P G+P  T+ L L GN L  +   
Sbjct: 24  PG-GSGGSCPAVCDCTSQPQA----VLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQG 78

Query: 93  AFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLG 152
               LS L  L+L   QL +LEP A  GL++L  L L+ N+LR +  G F+   AL  L 
Sbjct: 79  MLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLD 138

Query: 153 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVL--------AGN 204
           L  N++    DG F  LGSL  L +G N L  +   AF GL  L  L L         G 
Sbjct: 139 LRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGL 198

Query: 205 RLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLG 264
            LA L PAL +    LRELD+ R    A++     QL  L+ ++L  +L  A+ PG+ +G
Sbjct: 199 ALARL-PALVA--LRLRELDIGRLPAGALRG--LGQLKELE-IHLWPSL-EALDPGSLVG 251

Query: 265 LKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHN 324
           L  L  L ++   ++ +       L  LRVL LS N I+++  R    L  L+EL+L   
Sbjct: 252 LN-LSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGA 310

Query: 325 RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
            +  +A  +F GL    +L +  N LQ ++  AF     +  + LSGN L
Sbjct: 311 CLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360



 Score =  137 bits (344), Expect = 4e-32
 Identities = 108/301 (35%), Positives = 146/301 (48%), Gaps = 8/301 (2%)

Query: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 210
           L LS NRL  L+ G+   L  L +L+L +N L+ L   AF GL SL  L L GNRL  + 
Sbjct: 65  LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124

Query: 211 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 270
           P +FSGL+ L  LDL  N +       F +L  LQKL +  N +  VAPGAF GL  L  
Sbjct: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184

Query: 271 LDLSH---NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLG-HNRI 326
           L L     + V GL     P L+ LR+  L    I  L     + L  L+EL++     +
Sbjct: 185 LTLERCNLSTVPGLALARLPALVALRLRELD---IGRLPAGALRGLGQLKELEIHLWPSL 241

Query: 327 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 386
             L   S  GL  L  L +    L  V   A   L+ + V++LS N +  +P +    L 
Sbjct: 242 EALDPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV 300

Query: 387 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 446
           +L  L L G+CL  I  H F GL+    L + DN L  +EE +     +L+ L L+ N L
Sbjct: 301 RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360

Query: 447 T 447
           T
Sbjct: 361 T 361



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 101/356 (28%), Positives = 149/356 (41%), Gaps = 63/356 (17%)

Query: 284 DTFPGLLGL--RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLE 341
           +  PG L L   +L LS N +  L+      L  L+EL L +N++  L   +F GL  L 
Sbjct: 52  EAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLL 111

Query: 342 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI 401
            L L  N+L+ +  G F GL+ + +++L  N +    +  F  LG L  L +  + L  +
Sbjct: 112 TLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFV 171

Query: 402 RPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 461
            P  F GL+ L  L L+   L  +   +L  L  L+ L L    +  LP    +GLG+L+
Sbjct: 172 APGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLK 231

Query: 462 ------------------------YLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEAL 497
                                    L ++R  L+ +P  AL  L     LD+S N + A+
Sbjct: 232 ELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAI 291

Query: 498 PNSLLAPLGRLRYLSL------------------------RNNSLRTFT----PQPPGLE 529
           P   L+PL RL+ L L                         +N+L+T      P P  L 
Sbjct: 292 PARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLV 351

Query: 530 RLWLEGNPWDCGCPLKAL------RDFALQNPS-AVPRFVQ--AICEGDDCQPPAY 576
            L L GNP  C C L  L       DF +  P+ A P  VQ  ++ E  D  PP +
Sbjct: 352 TLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGH 407


>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
           [Homo sapiens]
          Length = 1052

 Score =  140 bits (354), Expect = 3e-33
 Identities = 130/364 (35%), Positives = 176/364 (48%), Gaps = 12/364 (3%)

Query: 131 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 190
           R+ LR L L      P   +  L +    +L   L   LG +  LNLG N L  +P+   
Sbjct: 26  RSNLRQLTLTAAGACPGAGADALESPASPQLV--LPANLGDIEALNLGNNGLEEVPEGLG 83

Query: 191 RGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLD 250
             LGSLR LVL  NR A L PA+      L ELD+S N L A+ A V   L  L+KL L 
Sbjct: 84  SALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLS 143

Query: 251 RNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTF 310
            N + A+ P     L  L  LD+S NR+A  L D+   L  LR L + HN + +  PR  
Sbjct: 144 HNQLPAL-PAQLGALAHLEELDVSFNRLAH-LPDSLSCLSRLRTLDVDHNQLTAF-PRQL 200

Query: 311 KDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLS 370
             L  LEEL +  NR+R L E     L  L++L L   +L  + AG F  L ++  + L 
Sbjct: 201 LQLVALEELDVSSNRLRGLPE-DISALRALKILWLSGAELGTLPAG-FCELASLESLMLD 258

Query: 371 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 430
            N L+ LP Q F  L +L  L+L  +      P     L+GL  L+L  N L  +    +
Sbjct: 259 NNGLQALPAQ-FSCLQRLKMLNLSSNLFEEF-PAALLPLAGLEELYLSRNQLTSV-PSLI 315

Query: 431 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 490
            GL  LL L L +N++ +LP  + +  G LE L+L  N++A LP D  G L R     + 
Sbjct: 316 SGLGRLLTLWLDNNRIRYLPDSIVELTG-LEELVLQGNQIAVLP-DHFGQLSRVGLWKIK 373

Query: 491 HNRL 494
            N L
Sbjct: 374 DNPL 377



 Score =  117 bits (292), Expect = 4e-26
 Identities = 114/331 (34%), Positives = 154/331 (46%), Gaps = 37/331 (11%)

Query: 210 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 269
           Q  L + L ++  L+L  N L  +   +   L  L+ L L RN  A + P        L 
Sbjct: 55  QLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLT 114

Query: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 329
            LD+SHNR+  L  +    L  LR L LSHN + +L P     L  LEEL +  NR+  L
Sbjct: 115 ELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPAL-PAQLGALAHLEELDVSFNRLAHL 173

Query: 330 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 389
            + S   L +L  L +DHNQL        L L  +  +++S N LR LPE +   L  L 
Sbjct: 174 PD-SLSCLSRLRTLDVDHNQLTAFPR-QLLQLVALEELDVSSNRLRGLPEDI-SALRALK 230

Query: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
            L L G+ LG + P  F  L+ L  L L +NGL  +  Q                     
Sbjct: 231 ILWLSGAELGTL-PAGFCELASLESLMLDNNGLQALPAQ--------------------- 268

Query: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 509
               F  L +L+ L LS N   E PA AL PL     L +S N+L ++P SL++ LGRL 
Sbjct: 269 ----FSCLQRLKMLNLSSNLFEEFPA-ALLPLAGLEELYLSRNQLTSVP-SLISGLGRLL 322

Query: 510 YLSLRNNSLRTFTP----QPPGLERLWLEGN 536
            L L NN +R + P    +  GLE L L+GN
Sbjct: 323 TLWLDNNRIR-YLPDSIVELTGLEELVLQGN 352



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 106/334 (31%), Positives = 144/334 (43%), Gaps = 38/334 (11%)

Query: 74  GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 133
           G  +AL L  N L  VP      L SL  L L+  +   L P       +L  L +  N+
Sbjct: 63  GDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR 122

Query: 134 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 193
           L +L     +    L  L LS+N+L  L   L   L  L +L++ +N LA LPD +   L
Sbjct: 123 LTALGAEVVSALRELRKLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLPD-SLSCL 180

Query: 194 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANV---------------- 237
             LR L +  N+L    P     L  L ELD+S N LR +  ++                
Sbjct: 181 SRLRTLDVDHNQLTAF-PRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAEL 239

Query: 238 ------FVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPG--- 288
                 F +L  L+ L LD N + A+ P  F  L+ L+ L+LS N     L + FP    
Sbjct: 240 GTLPAGFCELASLESLMLDNNGLQAL-PAQFSCLQRLKMLNLSSN-----LFEEFPAALL 293

Query: 289 -LLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDH 347
            L GL  L LS N + S+ P     L  L  L L +NRIR L +   E  G LE L L  
Sbjct: 294 PLAGLEELYLSRNQLTSV-PSLISGLGRLLTLWLDNNRIRYLPDSIVELTG-LEELVLQG 351

Query: 348 NQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQV 381
           NQ+  V    F  L+ V +  +  N L   P +V
Sbjct: 352 NQI-AVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 71/201 (35%), Positives = 92/201 (45%), Gaps = 10/201 (4%)

Query: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
           L ++  +NL  N L  +PE +   LG L  L L  +   R+ P        L  L +  N
Sbjct: 62  LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121

Query: 421 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
            L  +  + +  L EL +L+L+ NQL  LP +L   L  LE L +S NRLA LP D+L  
Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLP-DSLSC 179

Query: 481 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER---LWLEG-- 535
           L R   LDV HN+L A P  LL  L  L  L + +N LR        L     LWL G  
Sbjct: 180 LSRLRTLDVDHNQLTAFPRQLL-QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAE 238

Query: 536 -NPWDCG-CPLKALRDFALQN 554
                 G C L +L    L N
Sbjct: 239 LGTLPAGFCELASLESLMLDN 259


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score =  140 bits (353), Expect = 3e-33
 Identities = 120/421 (28%), Positives = 197/421 (46%), Gaps = 36/421 (8%)

Query: 153 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA 212
           LS+NRLS ++      L SL ++ L  N L  +P+       ++  L LAGNR+  + P 
Sbjct: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 79

Query: 213 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 272
                  L  LDLS N +  ++   F  L +L+ LYL+ N + ++ PG F  L       
Sbjct: 80  HLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANT---- 133

Query: 273 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 332
                              L VL+L+ N I+++ P+ FK L  L+ L+L  N+I+ +   
Sbjct: 134 -------------------LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGL 173

Query: 333 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH 392
           +F+GLG L+ L +  N + ++  GAF GL+N+ ++ L  N L  + +    GL  L  LH
Sbjct: 174 TFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELH 233

Query: 393 LEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHR 452
           L  + + RI P  +     L  L L  N L  +++ S  GL+ L  L + +N+++++   
Sbjct: 234 LSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC 293

Query: 453 LFQGLGKLEYLLLSRNRLAELPAD---ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 509
            F+GL  L+ L L  N ++    D   A   L +   L +  NR+ ++       L  L 
Sbjct: 294 AFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALE 353

Query: 510 YLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAI 565
           +L L +N++ +       Q   L++L L  +   C C LK L  +  +N      FV A 
Sbjct: 354 HLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN--NFQSFVNAS 411

Query: 566 C 566
           C
Sbjct: 412 C 412



 Score =  138 bits (347), Expect = 2e-32
 Identities = 114/369 (30%), Positives = 180/369 (48%), Gaps = 30/369 (8%)

Query: 129 LERNQLRSLALGTFAHTPALASLGLSNNRL--------------------SRLEDGLFEG 168
           L  N+L  +   + +H  +L  + L+NN L                    +R+ + L E 
Sbjct: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEH 80

Query: 169 L---GSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE-LRELD 224
           L    SL  L+L  N+++ L   AF  L  L+ L L  NR+  ++P  F  LA  L  L 
Sbjct: 81  LKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLK 138

Query: 225 LSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED 284
           L+RN + AI   +F +LP+LQ L L+RN I  V    F GL AL+ L +  N V  L++ 
Sbjct: 139 LNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDG 197

Query: 285 TFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLT 344
            F GL  + +L+L HN +  +       L  L+EL L  N I +++  ++E   +L  L 
Sbjct: 198 AFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELD 257

Query: 345 LDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG---RI 401
           L  N L  +   +FLGL+ +  +++  N +  + +  FRGL  L +L L+ + +      
Sbjct: 258 LTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIED 317

Query: 402 RPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 461
               F+GL  LRRL L+ N +  I +++  GL  L  LDL+ N +  L    F  + KL+
Sbjct: 318 MNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQ 377

Query: 462 YLLLSRNRL 470
            L L+ + L
Sbjct: 378 QLHLNTSSL 386



 Score =  134 bits (337), Expect = 2e-31
 Identities = 97/295 (32%), Positives = 155/295 (52%), Gaps = 6/295 (2%)

Query: 61  SSRNLTRLPDGVPG-GTQALWLDGNNLSSVPPAAFQNLSS-LGFLNLQGGQLGSLEPQAL 118
           SS N++ L    P    + L+L+ N ++S+ P  F NL++ L  L L   ++ ++ P+ +
Sbjct: 93  SSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK-M 151

Query: 119 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 178
             L  L HL L RN+++++   TF    AL SL +  N +++L DG F GL ++  L L 
Sbjct: 152 FKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 211

Query: 179 WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVF 238
            N+L  +      GL  L+EL L+ N +  + P  +    +L ELDL+ N L  +  + F
Sbjct: 212 HNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF 271

Query: 239 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVL 295
           + L  L  L++  N ++ +A  AF GL +L+ LDL +N ++  +ED    F GL  LR L
Sbjct: 272 LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRL 331

Query: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL 350
            L  N I S+  + F  L  LE L L  N I  L   +F  + +L+ L L+ + L
Sbjct: 332 ILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 79/269 (29%), Positives = 127/269 (47%), Gaps = 27/269 (10%)

Query: 272 DLSHNRVAGLLEDTFPGLLGLR-----------------------VLRLSHNAIASLRPR 308
           DLSHNR++ +   +   L  LR                       +L L+ N I  + P 
Sbjct: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79

Query: 309 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN-VAVM 367
             K+   LE L L  N I +L + +F  L QL+ L L+ N++  ++ G F  L N + V+
Sbjct: 80  HLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137

Query: 368 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 427
            L+ N +  +P ++F+ L +L  L L  + +  +   TF GL  L+ L ++ NG+  + +
Sbjct: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196

Query: 428 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 487
            + WGL+ +  L L  N LT +      GL  L+ L LS+N +  +  DA    Q+   L
Sbjct: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256

Query: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 516
           D++ N L  L +S    L  L  L + NN
Sbjct: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNN 285



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 31/237 (13%)

Query: 313 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG--LTNVAVMNLS 370
           L  +    L HNR+  +   S   L  L  + L++N+L+ +     LG    N+ +++L+
Sbjct: 13  LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN---LGPVSANITLLSLA 69

Query: 371 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE---- 426
           GN +  +  +  +    L +L L  + +  ++   F  L  L+ L+L  N +  +E    
Sbjct: 70  GNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYF 127

Query: 427 --------------------EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLS 466
                                  ++ L +L  L+L  N++ ++    FQGLG L+ L + 
Sbjct: 128 DNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 187

Query: 467 RNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523
           RN + +L   A   L     L + HN L  +    L  L  L+ L L  N++   +P
Sbjct: 188 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 244



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)

Query: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT---PQPPGLERLWLEGN 536
           D+SHNRL  +  S ++ L  LR + L NN L T     P    +  L L GN
Sbjct: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGN 71


>gi|45505137 podocan [Homo sapiens]
          Length = 661

 Score =  140 bits (352), Expect = 4e-33
 Identities = 156/531 (29%), Positives = 238/531 (44%), Gaps = 63/531 (11%)

Query: 25  LEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGN 84
           L   +PG PG A   +CP  C CS +   D     C   +L   P  +P  T  L L  N
Sbjct: 102 LSPEEPG-PGPA-AVSCPRDCACSQEGVVD-----CGGIDLREFPGDLPEHTNHLSLQNN 154

Query: 85  NLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQALLGLENLCHLHLERNQLRSLALGTF 142
            L  + P     L  L  LNLQ  +L S  L  +A   L NL +L+L  N+L    L   
Sbjct: 155 QLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKL---TLAPR 211

Query: 143 AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAV--LPDAAFRGLGSLRELV 200
               AL S+  + N L+++    F    +L  + L  N LA   LPD  F G  ++  L+
Sbjct: 212 FLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLI 271

Query: 201 LAGNRLAY----LQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA- 255
           L+ N L +    L PAL+       +L L  N L  I    F +L  L++LYL  N +  
Sbjct: 272 LSSNFLRHVPKHLPPALY-------KLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD 324

Query: 256 -AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLH 314
             +    F  L +L +LDLS N ++ +       L+   +L L  NAI S+       + 
Sbjct: 325 EGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLV---LLHLEKNAIRSVDANVLTPIR 381

Query: 315 FLEELQLGHNRIRQ--LAERSFEGLGQLEVLTLDHNQLQEVKAG---------------A 357
            LE L L  N++R+  +   +F+GL +L  + L +N L+ V +G                
Sbjct: 382 SLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQIT 441

Query: 358 FLGLTNVAV------MNLSGNCLRN--LPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL 409
            +G  + A       +NLS N + +  +    FR L  L SL L G+ L  + P     +
Sbjct: 442 GIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNV 501

Query: 410 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTH--LPHRLFQGLGKLEYLLLSR 467
             L+   +K N L  +   +L G+A+L EL LTSN+L    L  R +  L  L+ L ++ 
Sbjct: 502 HVLK---VKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAG 558

Query: 468 NRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
           N+L E+P      L+   +L + +N++ A+P +       L+ + LR N L
Sbjct: 559 NQLTEIPEGLPESLE---YLYLQNNKISAVPANAFDSTPNLKGIFLRFNKL 606



 Score =  109 bits (273), Expect = 6e-24
 Identities = 116/394 (29%), Positives = 178/394 (45%), Gaps = 46/394 (11%)

Query: 61  SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 120
           SS  L  +P  +P     L L  N L  +PP AF  LSSL  L LQ   L         G
Sbjct: 273 SSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD------EG 326

Query: 121 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 180
           L+N                 TF    +L  L LS+N LSR+  GL     SL  L+L  N
Sbjct: 327 LDN----------------ETFWKLSSLEYLDLSSNNLSRVPAGLPR---SLVLLHLEKN 367

Query: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAY--LQPALFSGLAELRELDLSRNALRAIKANVF 238
           ++  +       + SL  L+L  N+L    + P  F GL  L  + L  NAL  + +   
Sbjct: 368 AIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG-- 425

Query: 239 VQLP-RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG--LLEDTFPGLLGLRVL 295
             LP R++ L +  N I  +    F     L  L+LS+NR+    +  D F  L  LR L
Sbjct: 426 --LPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSL 483

Query: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 355
            LS N + +L P   +++H    L++  N +  LA  +  G+ QL  L L  N+L+    
Sbjct: 484 DLSGNRLHTLPPGLPRNVHV---LKVKRNELAALARGALVGMAQLRELYLTSNRLRSRAL 540

Query: 356 G--AFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK-LHSLHLEGSCLGRIRPHTFTGLSGL 412
           G  A++ L ++ +++++GN L  +PE    GL + L  L+L+ + +  +  + F     L
Sbjct: 541 GPRAWVDLAHLQLLDIAGNQLTEIPE----GLPESLEYLYLQNNKISAVPANAFDSTPNL 596

Query: 413 RRLFLKDNGLV--GIEEQSLWGLAELLELDLTSN 444
           + +FL+ N L    + + +   L  L  LD+  N
Sbjct: 597 KGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 90/292 (30%), Positives = 145/292 (49%), Gaps = 20/292 (6%)

Query: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVA--GLLEDTFPGLLGLRVLRLSHNAIAS 304
           L L  N +  + P     L  L  L+L +NR+   GL E  F  L  L  L L++N + +
Sbjct: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKL-T 207

Query: 305 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE--VKAGAFLGLT 362
           L PR   +   L  +    N + ++   +F     L  + L +N+L +  +    F G +
Sbjct: 208 LAPRFLPNA--LISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265

Query: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
           NV V+ LS N LR++P+ +   L KLH   L+ + L +I P  F+ LS LR L+L++N L
Sbjct: 266 NVEVLILSSNFLRHVPKHLPPALYKLH---LKNNKLEKIPPGAFSELSSLRELYLQNNYL 322

Query: 423 V--GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
              G++ ++ W L+ L  LDL+SN L+ +P  L + L  L    L +N +  + A+ L P
Sbjct: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLH---LEKNAIRSVDANVLTP 379

Query: 481 LQRAFWLDVSHNRL--EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 530
           ++   +L +  N+L  + +       L RL  + L NN+L      P GL R
Sbjct: 380 IRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERV---PSGLPR 428


>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
           sapiens]
          Length = 606

 Score =  136 bits (342), Expect = 6e-32
 Identities = 103/334 (30%), Positives = 160/334 (47%), Gaps = 4/334 (1%)

Query: 41  CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
           CPA C CS    A   SV C  R L  +P+G+P  T+ L L  N L SV P  F +   L
Sbjct: 28  CPARCECS----AQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLL 83

Query: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
             ++L    + ++EP A   L NL  L L+ N+L+ + LG F     L  L +S N++  
Sbjct: 84  EEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVI 143

Query: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
           L D +F+ L +L  L +G N L  +   AF GL SL +L L    L  +     S L  L
Sbjct: 144 LLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSL 203

Query: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
             L L    +  +    F +L  L+ L +D   +  + P   L    L  L +++  ++ 
Sbjct: 204 ISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLST 263

Query: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
           +    F  L+ L  L LS+N I+++    F DL  L+EL +   ++R +   SF+GL  L
Sbjct: 264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFL 323

Query: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
            VL +  N L+ ++   F     + V++++ N L
Sbjct: 324 RVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357



 Score =  122 bits (305), Expect = 1e-27
 Identities = 102/330 (30%), Positives = 150/330 (45%), Gaps = 28/330 (8%)

Query: 219 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 278
           E + LDLS+N L+++    F+  P L+++ L  N+IA V PGAF  L  LR L L  NR+
Sbjct: 58  ETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRL 117

Query: 279 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 338
             +    F GL  L  L +S N I  L    F+DLH L+ L++G N +  ++ R+F GL 
Sbjct: 118 KLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLL 177

Query: 339 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCL 398
            LE LTL+   L  V   A   L ++  ++L    + N+P   F+ L  L  L ++   L
Sbjct: 178 SLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPL 237

Query: 399 GRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLG 458
             + P                         SL+GL  L  L +T+  L+ +P   F+ L 
Sbjct: 238 LDMMP-----------------------ANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLV 273

Query: 459 KLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
            L +L LS N ++ + A     L R   L +   +L  +       L  LR L++  N L
Sbjct: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333

Query: 519 RTFTPQ----PPGLERLWLEGNPWDCGCPL 544
            T        P  LE L +  NP  C C L
Sbjct: 334 ETLEENVFSSPRALEVLSINNNPLACDCRL 363



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 55/179 (30%), Positives = 92/179 (51%)

Query: 77  QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 136
           + L L+  NL++VP  A  +L SL  L+L+   + ++   A   L +L HL ++   L  
Sbjct: 180 EQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLD 239

Query: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196
           +      +   L SL ++N  LS +    F+ L  L  LNL +N ++ +    F  L  L
Sbjct: 240 MMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRL 299

Query: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 255
           +EL + G +L  ++P  F GL  LR L++S+N L  ++ NVF     L+ L ++ N +A
Sbjct: 300 QELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLA 358


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score =  136 bits (342), Expect = 6e-32
 Identities = 104/328 (31%), Positives = 163/328 (49%), Gaps = 7/328 (2%)

Query: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
           N+  L L  N +  +        PAL SL LS+N +S ++   F  +  L  LNL  N +
Sbjct: 121 NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRI 179

Query: 183 AVLPDAAFRGLGS-LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQL 241
             L    F  L S L  + L  NR++ + P +F  L  L+ L+L RN ++ ++   F  L
Sbjct: 180 TTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGL 238

Query: 242 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA 301
             L+ L + RN I+ +  GAF GL  +  L+L HN +  + +    GL  L+ L +S NA
Sbjct: 239 DSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNA 298

Query: 302 IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGL 361
           I  + P  ++    L EL L +N++ +L E +F GL  LE L L  N++  +  G F  L
Sbjct: 299 IERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFL 358

Query: 362 TNVAVMNLSGNCLRNLPE---QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLK 418
           +N+  ++L  N +    E   + F GL  L  L L+G+ +  I    F GL  L  L L 
Sbjct: 359 SNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLN 418

Query: 419 DNGLVGIEEQSLWGLAELLELDLTSNQL 446
           +N ++ I+E + +    L EL L ++ L
Sbjct: 419 NNAIMSIQENA-FSQTHLKELILNTSSL 445



 Score =  129 bits (324), Expect = 8e-30
 Identities = 111/414 (26%), Positives = 194/414 (46%), Gaps = 34/414 (8%)

Query: 195 SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLI 254
           +L+E+ +  N L  + P      + +  L L  N +  I A      P L+ L L  N+I
Sbjct: 98  TLQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156

Query: 255 AAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG-LRVLRLSHNAIASLRPRTFKDL 313
           + +   +F  ++ L++L+LS+NR+  L    F  L   L V++L+ N ++ + P+ FK  
Sbjct: 157 SEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLP 215

Query: 314 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373
           H L+ L+L  NRI+ +   +F+GL  L  L +  N + ++K GAF GL N+  + L  N 
Sbjct: 216 H-LQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNN 274

Query: 374 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 433
           L  + +    GL  L  L++  + + RI P  +     L  L L  N L  ++E +  GL
Sbjct: 275 LTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGL 334

Query: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA---ELPADALGPLQRAFWLDVS 490
           + L  L+L  N++TH+   +F+ L  L+ L L  N ++   E  ++A   L     L + 
Sbjct: 335 SLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQ 394

Query: 491 HNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP---QPPGLERLWLEGNPWDCGCPLKAL 547
            N+++++       L  L +L L NN++ +          L+ L L  +   C C LK L
Sbjct: 395 GNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWL 454

Query: 548 RDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP-----PEVVGLDLRD 596
             + + N      F  ++              N++CA P       ++ +DL+D
Sbjct: 455 LQWLVDN-----NFQHSV--------------NVSCAHPEWLAGQSILNVDLKD 489



 Score =  121 bits (304), Expect = 2e-27
 Identities = 83/257 (32%), Positives = 129/257 (50%), Gaps = 3/257 (1%)

Query: 81  LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 140
           L  N ++++    F NLSS   +        S+ P  +  L +L  L L+RN+++ +   
Sbjct: 174 LSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGL 233

Query: 141 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 200
           TF    +L SL +  N +S+L+DG F GL ++ +L L  N+L  +      GL  L++L 
Sbjct: 234 TFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLY 293

Query: 201 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 260
           ++ N +  + P  +     L ELDLS N L  +  + FV L  L++L L  N +  +A G
Sbjct: 294 VSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADG 353

Query: 261 AFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLE 317
            F  L  L+ LDL +N ++  +ED    F GL  L  L L  N I S+  + F  L  LE
Sbjct: 354 VFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLE 413

Query: 318 ELQLGHNRIRQLAERSF 334
            L L +N I  + E +F
Sbjct: 414 HLDLNNNAIMSIQENAF 430



 Score =  104 bits (260), Expect = 2e-22
 Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 3/213 (1%)

Query: 77  QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 136
           Q L L  N +  V    FQ L SL  L +Q   +  L+  A  GL N+  L LE N L  
Sbjct: 218 QFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTR 277

Query: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196
           +  G       L  L +S N + R+    +E    L +L+L +N L  L ++AF GL  L
Sbjct: 278 VNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLL 337

Query: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALR-AIK--ANVFVQLPRLQKLYLDRNL 253
             L L  NR+ ++   +F  L+ L+ LDL  N +  AI+  +  F  L  L KL L  N 
Sbjct: 338 ERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQ 397

Query: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTF 286
           I ++   AF+GL++L  LDL++N +  + E+ F
Sbjct: 398 IKSITKKAFIGLESLEHLDLNNNAIMSIQENAF 430



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 33/87 (37%), Positives = 47/87 (54%), Gaps = 6/87 (6%)

Query: 65  LTRLPDGV---PGGTQALWLDGNNLS-SVPPA--AFQNLSSLGFLNLQGGQLGSLEPQAL 118
           +T + DGV       Q L L  N +S ++  A  AF  L+SL  L LQG Q+ S+  +A 
Sbjct: 347 VTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAF 406

Query: 119 LGLENLCHLHLERNQLRSLALGTFAHT 145
           +GLE+L HL L  N + S+    F+ T
Sbjct: 407 IGLESLEHLDLNNNAIMSIQENAFSQT 433


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score =  131 bits (329), Expect = 2e-30
 Identities = 89/237 (37%), Positives = 125/237 (52%), Gaps = 4/237 (1%)

Query: 41  CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
           CP ACVC Y++   +++  C  + L  +P G+P  +Q ++L GN +S VP A+F+   +L
Sbjct: 27  CPGACVC-YNEP--KVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNL 83

Query: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERN-QLRSLALGTFAHTPALASLGLSNNRLS 159
             L L    L  ++  A  GL  L  L L  N QLRS+   TF     L +L L    L 
Sbjct: 84  TILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQ 143

Query: 160 RLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 219
            L  GLF GL +L  L L  N+L  LPD  FR LG+L  L L GNR++ +    F GL  
Sbjct: 144 ELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHS 203

Query: 220 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN 276
           L  L L +N +  +  + F  L RL  LYL  N ++A+   A   L+AL++L L+ N
Sbjct: 204 LDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260



 Score =  126 bits (316), Expect = 7e-29
 Identities = 81/232 (34%), Positives = 115/232 (49%), Gaps = 21/232 (9%)

Query: 317 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LR 375
           + + L  NRI  +   SF     L +L L  N L  + A AF GL  +  ++LS N  LR
Sbjct: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119

Query: 376 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 435
           ++    F GLG+LH+LHL+   L  + P  F GL+ L+ L+L+DN L  + + +   L  
Sbjct: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179

Query: 436 LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE 495
           L  L L  N+++ +P R F+GL  L+ LLL +NR+A +   A   L R   L +  N L 
Sbjct: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239

Query: 496 ALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKAL 547
           ALP   LAPL  L+YL L +                    NPW C C  + L
Sbjct: 240 ALPTEALAPLRALQYLRLND--------------------NPWVCDCRARPL 271



 Score =  109 bits (273), Expect = 6e-24
 Identities = 75/194 (38%), Positives = 104/194 (53%), Gaps = 1/194 (0%)

Query: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA-LRAIKANVF 238
           N ++ +P A+FR   +L  L L  N LA +  A F+GLA L +LDLS NA LR++    F
Sbjct: 67  NRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATF 126

Query: 239 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLS 298
             L RL  L+LDR  +  + PG F GL AL++L L  N +  L +DTF  L  L  L L 
Sbjct: 127 HGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLH 186

Query: 299 HNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 358
            N I+S+  R F+ LH L+ L L  NR+  +   +F  LG+L  L L  N L  +   A 
Sbjct: 187 GNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEAL 246

Query: 359 LGLTNVAVMNLSGN 372
             L  +  + L+ N
Sbjct: 247 APLRALQYLRLNDN 260



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 68/201 (33%), Positives = 96/201 (47%), Gaps = 1/201 (0%)

Query: 245 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA-IA 303
           Q+++L  N I+ V   +F   + L  L L  N +A +    F GL  L  L LS NA + 
Sbjct: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119

Query: 304 SLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 363
           S+ P TF  L  L  L L    +++L    F GL  L+ L L  N LQ +    F  L N
Sbjct: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179

Query: 364 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 423
           +  + L GN + ++PE+ FRGL  L  L L  + +  + PH F  L  L  L+L  N L 
Sbjct: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239

Query: 424 GIEEQSLWGLAELLELDLTSN 444
            +  ++L  L  L  L L  N
Sbjct: 240 ALPTEALAPLRALQYLRLNDN 260


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  130 bits (326), Expect = 5e-30
 Identities = 114/418 (27%), Positives = 172/418 (41%), Gaps = 24/418 (5%)

Query: 40  ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSS 99
           ACPA C C+        +V C    L  +P  +P  T+ L L+GNN++ +    F  L  
Sbjct: 33  ACPALCTCT------GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQ 86

Query: 100 LGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLS 159
           L  L L   Q+G++E  A   ++ L  L L RNQL  L    F +  AL+ L LS N + 
Sbjct: 87  LRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQ 146

Query: 160 RLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 219
            +    F G   L +L L  N ++ + + AFR L  L  L L  N +  +  + F+ + +
Sbjct: 147 AIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPK 206

Query: 220 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA----AVAPGAFLGLKALR----WL 271
           LR   L  N L          L  L +    R  I        P +  GL          
Sbjct: 207 LRTFRLHSNHLFC-----DCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEF 261

Query: 272 DLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL-----HFLEELQLGHNRI 326
             S    AG +            +    N I   R +    +       + E++L  N I
Sbjct: 262 SCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321

Query: 327 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 386
           + +   +F    +L  + L +NQ+ E+   AF GL ++  + L GN + +LP  VF GL 
Sbjct: 322 KSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLY 381

Query: 387 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSN 444
            L  L L  + +  IRP  F  L  L  L L DN +  + + +   L  +  L L  N
Sbjct: 382 TLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN 439



 Score =  124 bits (310), Expect = 3e-28
 Identities = 118/421 (28%), Positives = 175/421 (41%), Gaps = 44/421 (10%)

Query: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 210
           L L+ N ++R+    F GL  L  L L  N +  +   AF  +  L  L L  N+L  L 
Sbjct: 66  LELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLP 125

Query: 211 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 270
             LF     L  LDLS NA++AI    F     L+ L LD+N I+ +  GAF  L+ L  
Sbjct: 126 ELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEV 185

Query: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI------------ASLRPRTFKDLHFLEE 318
           L L++N +  +   +F  +  LR  RL  N +               RP           
Sbjct: 186 LTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGP 245

Query: 319 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL---- 374
             L    + ++ +  F   GQ E   +    L      A    +N  +++  G  L    
Sbjct: 246 ASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSN-GIVDCRGKGLTAIP 304

Query: 375 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 434
            NLPE        +  + LE + +  I P  F+    LRR+ L +N +  I   +  GL 
Sbjct: 305 ANLPE-------TMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLR 357

Query: 435 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
            L  L L  N++T LP  +F GL  L+ LLL+ N++  +  DA   LQ    L +  N++
Sbjct: 358 SLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKI 417

Query: 495 EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQN 554
           ++L            + SLR             ++ L L  NP+ C C LK L DF   N
Sbjct: 418 QSLAKG--------TFTSLR------------AIQTLHLAQNPFICDCNLKWLADFLRTN 457

Query: 555 P 555
           P
Sbjct: 458 P 458



 Score =  111 bits (278), Expect = 2e-24
 Identities = 152/613 (24%), Positives = 235/613 (38%), Gaps = 121/613 (19%)

Query: 40  ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSS 99
           +CPA C CS         V C  + LT +P  +P     + L+ N + S+PP AF     
Sbjct: 281 SCPAMCTCSNG------IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK 334

Query: 100 LGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGT------------------ 141
           L  ++L   Q+  + P A  GL +L  L L  N++  L  G                   
Sbjct: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394

Query: 142 ------FAHTPALASLGLSNNRLSRLEDGLFEGLGSLW-----------DLNLGW--NSL 182
                 F     L+ L L +N++  L  G F  L ++            D NL W  + L
Sbjct: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFL 454

Query: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE-------LRELDLSRNALRAI-- 233
              P     G        LA  R+  ++   F   A+         +  L+      +  
Sbjct: 455 RTNPIET-SGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVC 513

Query: 234 ------KANV-------FVQLPR-----LQKLYLDRNLIAAV-APGAFLGLKALRWLDLS 274
                 +ANV         ++P        +L L+ N I+ + A G F  L  L+ ++LS
Sbjct: 514 PHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLS 573

Query: 275 HNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSF 334
           +N+V+ + +  F G   +  L L+ N + S+R   F+ L  L  L L +NRI  +   SF
Sbjct: 574 NNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSF 633

Query: 335 EGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN---------------------- 372
            GL  + +L+L  NQ+  V  GAF  L +++ +NL  N                      
Sbjct: 634 TGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVT 693

Query: 373 ---------CLRNLPEQ--VFRGLGKLHSLHLEGSCLGRIR-PHTFTGLSGLRRLFLKDN 420
                     LR +P Q   F    +      EG CL R + P     L  + R   K  
Sbjct: 694 GNPRCQNPDFLRQIPLQDVAFPDF-RCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHL 752

Query: 421 GLV--GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADAL 478
             +  GI +        + EL L  NQ T +P +L      L+ + LS N+++ L   + 
Sbjct: 753 RALPKGIPKN-------VTELYLDGNQFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSF 804

Query: 479 GPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPPGLERLWLE 534
             + +   L +S+N L+ +P      L  LR LSL  N + T           L  L + 
Sbjct: 805 TNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIG 864

Query: 535 GNPWDCGCPLKAL 547
            NP  C C L+ L
Sbjct: 865 ANPLYCDCHLRWL 877



 Score =  110 bits (275), Expect = 4e-24
 Identities = 106/374 (28%), Positives = 158/374 (42%), Gaps = 54/374 (14%)

Query: 30  PGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 89
           PGT        C +  VC +    +   V CSS  LT++P+ +P  T  L L+ N +S +
Sbjct: 496 PGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISIL 555

Query: 90  PPAA-FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPAL 148
                F+ L+ L  +NL   ++  +E  A  G  ++  LHL  NQL S+  G F     L
Sbjct: 556 EATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGL 615

Query: 149 ASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGN---- 204
            +L L NNR+S + +  F GL ++  L+L  N +  +   AF  L SL  L L  N    
Sbjct: 616 RTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNC 675

Query: 205 --RLAYL-----QPALFSGLAE------LRELDLSRNALRAIKANVFVQ----LPRLQ-- 245
             +LA+L     +  + +G         LR++ L   A    +     +    LPR Q  
Sbjct: 676 NCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCP 735

Query: 246 -----------------------------KLYLDRNLIAAVAPGAFLGLKALRWLDLSHN 276
                                        +LYLD N    V PG     K L+ +DLS+N
Sbjct: 736 QECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLV-PGQLSTFKYLQLVDLSNN 794

Query: 277 RVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEG 336
           +++ L   +F  +  L  L LS+NA+  + P  F+ L  L  L L  N I  L E  F  
Sbjct: 795 KISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFAD 854

Query: 337 LGQLEVLTLDHNQL 350
           +  L  L +  N L
Sbjct: 855 VTSLSHLAIGANPL 868



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 52/154 (33%), Positives = 74/154 (48%)

Query: 317 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRN 376
           E L+L  N I ++ +  F GL QL VL L  NQ+  V+ GAF  +  +  + L+ N L  
Sbjct: 64  ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHM 123

Query: 377 LPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAEL 436
           LPE +F+    L  L L  + +  I    F G + L+ L L  N +  IEE +   L  L
Sbjct: 124 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGL 183

Query: 437 LELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 470
             L L +N +T +P   F  + KL    L  N L
Sbjct: 184 EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 49/160 (30%), Positives = 72/160 (45%), Gaps = 9/160 (5%)

Query: 23  RSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLD 82
           R  EG + G  G    P CP  C C       +  V CS+++L  LP G+P     L+LD
Sbjct: 718 RCEEGQEEG--GCLPRPQCPQECACL------DTVVRCSNKHLRALPKGIPKNVTELYLD 769

Query: 83  GNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTF 142
           GN  + V P        L  ++L   ++ SL   +   +  L  L L  N L+ +    F
Sbjct: 770 GNQFTLV-PGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAF 828

Query: 143 AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
               +L  L L  N +S L++G+F  + SL  L +G N L
Sbjct: 829 QGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 42/156 (26%), Positives = 73/156 (46%)

Query: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
           N   + L+GN +  + +  F GL +L  L L  + +G +    F  +  L RL L  N L
Sbjct: 62  NTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121

Query: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
             + E        L  LDL+ N +  +P + F+G   L+ L L +N+++ +   A   L+
Sbjct: 122 HMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALR 181

Query: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
               L +++N +  +P S    + +LR   L +N L
Sbjct: 182 GLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.140    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,771,978
Number of Sequences: 37866
Number of extensions: 1188037
Number of successful extensions: 8294
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 203
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 2875
Number of HSP's gapped (non-prelim): 2063
length of query: 605
length of database: 18,247,518
effective HSP length: 108
effective length of query: 497
effective length of database: 14,157,990
effective search space: 7036521030
effective search space used: 7036521030
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press