Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 40806207
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
(870 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 1808 0.0
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 1072 0.0
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 979 0.0
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 906 0.0
gi|40806209 WW domain containing E3 ubiquitin protein ligase 2 i... 677 0.0
gi|114520609 neural precursor cell expressed, developmentally do... 520 e-147
gi|114520607 neural precursor cell expressed, developmentally do... 520 e-147
gi|21361472 neural precursor cell expressed, developmentally dow... 513 e-145
gi|222352094 neural precursor cell expressed, developmentally do... 513 e-145
gi|222352092 neural precursor cell expressed, developmentally do... 513 e-145
gi|222352090 neural precursor cell expressed, developmentally do... 513 e-145
gi|222352183 neural precursor cell expressed, developmentally do... 508 e-143
gi|222352088 neural precursor cell expressed, developmentally do... 508 e-143
gi|222352086 neural precursor cell expressed, developmentally do... 508 e-143
gi|222352084 neural precursor cell expressed, developmentally do... 508 e-143
gi|222352082 neural precursor cell expressed, developmentally do... 508 e-143
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 474 e-133
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 459 e-129
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 447 e-125
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 379 e-105
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 365 e-100
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 321 2e-87
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 279 7e-75
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 213 8e-55
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 213 8e-55
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 213 8e-55
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 203 5e-52
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 198 2e-50
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 179 1e-44
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 179 1e-44
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 1808 bits (4683), Expect = 0.0
Identities = 870/870 (100%), Positives = 870/870 (100%)
Query: 1 MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI 60
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI
Sbjct: 1 MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI 60
Query: 61 GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT 120
GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT
Sbjct: 61 GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT 120
Query: 121 LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ 180
LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ
Sbjct: 121 LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ 180
Query: 181 PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT 240
PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT
Sbjct: 181 PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT 240
Query: 241 TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD 300
TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD
Sbjct: 241 TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD 300
Query: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQR 360
ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQR
Sbjct: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQR 360
Query: 361 PTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRV 420
PTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRV
Sbjct: 361 PTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRV 420
Query: 421 YYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFE 480
YYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFE
Sbjct: 421 YYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFE 480
Query: 481 SGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDL 540
SGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDL
Sbjct: 481 SGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDL 540
Query: 541 RRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPD 600
RRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPD
Sbjct: 541 RRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPD 600
Query: 601 HLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE 660
HLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE
Sbjct: 601 HLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE 660
Query: 661 NNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQ 720
NNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQ
Sbjct: 661 NNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQ 720
Query: 721 TKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFW 780
TKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFW
Sbjct: 721 TKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFW 780
Query: 781 QVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFN 840
QVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFN
Sbjct: 781 QVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFN 840
Query: 841 RLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
RLDLPPYKSYEQLREKLLYAIEETEGFGQE
Sbjct: 841 RLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 1072 bits (2773), Expect = 0.0
Identities = 551/919 (59%), Positives = 657/919 (71%), Gaps = 82/919 (8%)
Query: 19 QLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQ 78
QL + V SAK K Y EV VDG E KT K SS W+E + +NVT Q
Sbjct: 19 QLQVTVSSAKLKRKKNWFGTAIYTEVVVDG---EITKTAKSSSSSNPKWDEQLTVNVTPQ 75
Query: 79 SHLDLKVWSCHTLRNE-LLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGEL 137
+ L+ +VWS TL+ + LLG A+++L L + K+E ++ L L ENK + GEL
Sbjct: 76 TTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLENKNGIAQTGEL 135
Query: 138 TIFLDGPTVDLGNVPN------------GSALTDGSQLPSRDSSGTAVAPEN---RHQPP 182
T+ LDG ++ N+ N G AL + + +R ++ AV N H P
Sbjct: 136 TVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPT 195
Query: 183 STNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGH-----SGLANGTVND 237
ST S + G+ +P + S+ KN+ S A+ TVN
Sbjct: 196 STLVQN-----------SCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNG 244
Query: 238 EPTTATDPEEPSVVG------------------VTSPPAAPLSVTPNPNTTSLPAPATPA 279
E ++ + SV G V PP + +T + N +P+ +
Sbjct: 245 ESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEI-LTSSENNECIPSTSAEL 303
Query: 280 EGE-----EPSTSGTQQLPAAAQA----PDA----------------LPAGWEQRELPNG 314
E E EP TS ++ A A PD LP+GWEQR+ P+G
Sbjct: 304 ESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHG 363
Query: 315 RVYYVDHNTKTTTWERP--LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQW 372
R YYVDHNT+TTTWERP LPPGWE+R D R R YYVDHNTRTTTWQRPT E VRN+EQW
Sbjct: 364 RTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQW 423
Query: 373 QSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDN-GRVYYVNHNTRTTQ 431
QSQRNQLQGAMQ F+QR+LY +S + ++DP GPLPPGWEKR D+ RVY+VNHNT+TTQ
Sbjct: 424 QSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQ 483
Query: 432 WEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAY 491
WEDPRTQG+ E LP GWE++YT EGVRYFVDHNTRTTTFKDPR G S TK G AY
Sbjct: 484 WEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAY 543
Query: 492 DRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGE 551
+R FRWK FR+LC SNALPSHVKI+VSRQTLFEDSFQQIM +KPYDLRRRLY+I RGE
Sbjct: 544 ERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGE 603
Query: 552 EGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRF 611
EGLDYGG+AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPAS+INPDHL+YF FIGRF
Sbjct: 604 EGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRF 663
Query: 612 IAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELY 671
IAMAL+HGKFIDTGF+LPFYKRML+K+ T+KDLESID EFYNS++WI++NN+EECGLE+Y
Sbjct: 664 IAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMY 723
Query: 672 FIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV 731
F DMEILGKVT+H+LK GG +I VTEENK+EYI L+T+WRF+RGV+EQTKAFLDGFNEV
Sbjct: 724 FSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEV 783
Query: 732 APLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKR 791
PL+WL+YFDEKELE+MLCGMQE+D++DWQ++T+YRHYT+NSKQI WFWQ VKE DNE R
Sbjct: 784 VPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVR 843
Query: 792 IRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYE 851
+RLLQFVTGTCRLP+GGFAEL+GSNGPQKFCI+KVGK+TWLPRSHTCFNRLDLPPYKSYE
Sbjct: 844 MRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYE 903
Query: 852 QLREKLLYAIEETEGFGQE 870
QL+EKLL+AIEETEGFGQE
Sbjct: 904 QLKEKLLFAIEETEGFGQE 922
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 979 bits (2530), Expect = 0.0
Identities = 515/888 (57%), Positives = 631/888 (71%), Gaps = 44/888 (4%)
Query: 1 MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQ---PRINSYVEVAVDGLPSETKKTG 57
M+ + S + KSQL + V+SAK K + + P + YVEV VDG ++KKT
Sbjct: 1 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGP--SPYVEVTVDG---QSKKTE 55
Query: 58 KRIGSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNE-LLGTASVNLSNVLKNNGGKMEN 116
K ++ W + + + VT S L +VWS TL+++ LLGTA++++ LK+N K+E
Sbjct: 56 KCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEE 115
Query: 117 MQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPE 176
+ +TL L + K + G+L+I LDG ++ V NG T S+ S++ G+ E
Sbjct: 116 VVVTLQLGGD-KEPTETIGDLSICLDGLQLESEVVTNGE--TTCSESASQNDDGSRSKDE 172
Query: 177 NRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGAR------SRHRQPVKNSGHSGL 230
R STN G +G + R + G SP SR +P + +
Sbjct: 173 TR---VSTN--GSDDPEDAGAGENRRVS---GNNSPSLSNGGFKPSRPPRPSRPPPPTPR 224
Query: 231 ANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQ 290
+VN P+ AT + S G + PP + T T+ L P T + G SG +
Sbjct: 225 RPASVNGSPS-ATSESDGSSTG-SLPPTNTNTNTSEGATSGLIIPLTISGG-----SGPR 277
Query: 291 QLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP--LPPGWEKRTDPRGRFYY 348
L QAP LP GWEQR +GRVYYVDH K TTW+RP LPPGWE+R D GR YY
Sbjct: 278 PLNPVTQAP--LPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYY 335
Query: 349 VDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQS-----SSASTDHDP 403
VDH TRTTTWQRPT E VRNYEQWQ QR+QLQGAMQ F+QRF+Y + +S S + DP
Sbjct: 336 VDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDP 395
Query: 404 LGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYF 462
LGPLPPGWEKR D NGRVY+VNHNTR TQWEDPR+QG + E LP GWEM++T +G+ YF
Sbjct: 396 LGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYF 455
Query: 463 VDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQ 522
VDHN RTTT+ DPR G +S G AY R F+ K FRF C A+P H+KI+V+R+
Sbjct: 456 VDHNRRTTTYIDPRTG-KSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRK 514
Query: 523 TLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYA 582
TLFEDSFQQIM+ P DLRRRL++I GEEGLDYGG+AREWFFLLSHEVLNPMYCLFEYA
Sbjct: 515 TLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYA 574
Query: 583 GKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLK 642
GK+NYCLQINPAS INPDHL YFRFIGRFIAMAL+HGKFIDTGF+LPFYKR+LNK LK
Sbjct: 575 GKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLK 634
Query: 643 DLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKE 702
DLESIDPEFYNS++W+KENN+EEC LE+YF D EILG++ +H+LK G +I VTEENKE
Sbjct: 635 DLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKE 694
Query: 703 EYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQK 762
EYI ++ +WR +RGVEEQT+AF +GFNE+ P ++L+YFD KELE++LCGMQEID++DWQ+
Sbjct: 695 EYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQR 754
Query: 763 STIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFC 822
IYRHY + SKQI WFWQ VKE+DNEKR+RLLQFVTGTCRLPVGGFA+L+GSNGPQKFC
Sbjct: 755 HAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFC 814
Query: 823 IDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
I+KVGKE WLPRSHTCFNRLDLPPYKSYEQL+EKLL+AIEETEGFGQE
Sbjct: 815 IEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 862
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 906 bits (2342), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 440 MIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY 499
MIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY
Sbjct: 1 MIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY 60
Query: 500 HQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGI 559
HQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGI
Sbjct: 61 HQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGI 120
Query: 560 AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHG 619
AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHG
Sbjct: 121 AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHG 180
Query: 620 KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEIL 679
KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEIL
Sbjct: 181 KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEIL 240
Query: 680 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 739
GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY
Sbjct: 241 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 300
Query: 740 FDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVT 799
FDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVT
Sbjct: 301 FDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVT 360
Query: 800 GTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLY 859
GTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLY
Sbjct: 361 GTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLY 420
Query: 860 AIEETEGFGQE 870
AIEETEGFGQE
Sbjct: 421 AIEETEGFGQE 431
Score = 46.2 bits (108), Expect = 1e-04
Identities = 24/68 (35%), Positives = 34/68 (50%)
Query: 329 ERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQ 388
E LPPGWE + G Y+VDHNTRTTT++ P + +Q ++
Sbjct: 4 EPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQF 63
Query: 389 RFLYQSSS 396
RFL S++
Sbjct: 64 RFLCHSNA 71
Score = 45.1 bits (105), Expect = 3e-04
Identities = 21/40 (52%), Positives = 27/40 (67%), Gaps = 1/40 (2%)
Query: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRT 340
ALP GWE + G Y+VDHNT+TTT++ P PG+E T
Sbjct: 6 ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP-RPGFESGT 44
>gi|40806209 WW domain containing E3 ubiquitin protein ligase 2
isoform 3 [Homo sapiens]
Length = 335
Score = 677 bits (1747), Expect = 0.0
Identities = 335/335 (100%), Positives = 335/335 (100%)
Query: 1 MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI 60
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI
Sbjct: 1 MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI 60
Query: 61 GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT 120
GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT
Sbjct: 61 GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT 120
Query: 121 LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ 180
LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ
Sbjct: 121 LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ 180
Query: 181 PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT 240
PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT
Sbjct: 181 PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT 240
Query: 241 TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD 300
TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD
Sbjct: 241 TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD 300
Query: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG 335
ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG
Sbjct: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG 335
Score = 48.1 bits (113), Expect = 3e-05
Identities = 24/52 (46%), Positives = 30/52 (57%), Gaps = 7/52 (13%)
Query: 433 EDPRTQGMIQEPA-------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 477
E+P T G Q PA LP GWE + G Y+VDHNT+TTT++ P P
Sbjct: 282 EEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLP 333
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 520 bits (1338), Expect = e-147
Identities = 269/557 (48%), Positives = 367/557 (65%), Gaps = 31/557 (5%)
Query: 332 LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFL 391
LPPGWE++ D RGR YYVDHN+RTTTW +PT + Q S ++ Q +
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 409
Query: 392 YQSSSASTDHDPLGPLPPGWEKRQ-DNGRVYYVNHNTRTTQWEDPRTQGMIQEPA----- 445
Q + S G LP GWE R NGR ++++HNT+TT WEDPR ++ PA
Sbjct: 410 QQVTQPSEIEQ--GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPR----LKIPAHLRGK 463
Query: 446 -----------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRS 494
LPPGWE + ++G ++++HN + T ++DPR E+ G Y R
Sbjct: 464 TSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPR--LENVAITGPAVPYSRD 521
Query: 495 FRWKYHQFRF-LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEE 552
++ KY FR L N +P+ ++ + R T+ EDS+++IM +K D L+ RL+I GE+
Sbjct: 522 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 581
Query: 553 GLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRF 611
GLDYGG+AREWFFL+S E+ NP Y LFEY+ +NY LQINP S + N DHL+YF+FIGR
Sbjct: 582 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 641
Query: 612 IAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELY 671
MA+YHGK +D F PFYK ML+K TL D+ES+D E+YNS+ WI EN+ E L+L
Sbjct: 642 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLR 699
Query: 672 FIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV 731
FI D E+ G+ HELK GG I VT +NK+EYI L+ WRF +++Q AF +GF E+
Sbjct: 700 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 759
Query: 732 APLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEK 790
P + ++ FDE ELEL++CG+ ++D++DW++ T Y++ Y+ N + IQWFW+ V MD+EK
Sbjct: 760 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 819
Query: 791 RIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSY 850
RIRLLQFVTGT R+P+ GFAEL GSNGPQ F +++ G LPR+HTCFNRLDLPPY+S+
Sbjct: 820 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 879
Query: 851 EQLREKLLYAIEETEGF 867
E+L +KL AIE T+GF
Sbjct: 880 EELWDKLQMAIENTQGF 896
Score = 91.3 bits (225), Expect = 4e-18
Identities = 47/119 (39%), Positives = 58/119 (48%), Gaps = 22/119 (18%)
Query: 270 TSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWE 329
TS + A P S SG Q + LP GWE R PNGR +++DHNTKTTTWE
Sbjct: 391 TSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE 450
Query: 330 ----------------------RPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYV 366
PLPPGWE+RT GR +Y++HN + T W+ P E V
Sbjct: 451 DPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 509
Score = 79.3 bits (194), Expect = 1e-14
Identities = 68/241 (28%), Positives = 96/241 (39%), Gaps = 62/241 (25%)
Query: 284 PSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPR 343
P TSG++ A+ + L GW + P+ + + PLPPGWE+R D
Sbjct: 152 PKTSGSED--DNAEQAEELEPGWVVLDQPDAACHLQQQQEPS-----PLPPGWEERQDIL 204
Query: 344 GRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDP 403
GR YYV+H +R T W+RPT + N ++ QLQ A + F+ R + S D+
Sbjct: 205 GRTYYVNHESRRTQWKRPTPQ--DNLTDAENGNIQLQ-AQRAFTTRRQISEETESVDNRE 261
Query: 404 LGPLPPGWE-KRQDNGRVY----------------------------------------- 421
WE R+D +Y
Sbjct: 262 SS---ENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPAS 318
Query: 422 YVNHNTRT------TQWEDPRTQGMI-QEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKD 474
NH++R T E P ++ LPPGWE K G Y+VDHN+RTTT+
Sbjct: 319 SSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTK 378
Query: 475 P 475
P
Sbjct: 379 P 379
Score = 39.3 bits (90), Expect = 0.016
Identities = 18/37 (48%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 442 QEPA-LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 477
QEP+ LPPGWE + G Y+V+H +R T +K P P
Sbjct: 188 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTP 224
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 520 bits (1338), Expect = e-147
Identities = 269/557 (48%), Positives = 367/557 (65%), Gaps = 31/557 (5%)
Query: 332 LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFL 391
LPPGWE++ D RGR YYVDHN+RTTTW +PT + Q S ++ Q +
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 756
Query: 392 YQSSSASTDHDPLGPLPPGWEKRQ-DNGRVYYVNHNTRTTQWEDPRTQGMIQEPA----- 445
Q + S G LP GWE R NGR ++++HNT+TT WEDPR ++ PA
Sbjct: 757 QQVTQPSEIEQ--GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPR----LKIPAHLRGK 810
Query: 446 -----------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRS 494
LPPGWE + ++G ++++HN + T ++DPR E+ G Y R
Sbjct: 811 TSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPR--LENVAITGPAVPYSRD 868
Query: 495 FRWKYHQFRF-LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEE 552
++ KY FR L N +P+ ++ + R T+ EDS+++IM +K D L+ RL+I GE+
Sbjct: 869 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 928
Query: 553 GLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRF 611
GLDYGG+AREWFFL+S E+ NP Y LFEY+ +NY LQINP S + N DHL+YF+FIGR
Sbjct: 929 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 988
Query: 612 IAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELY 671
MA+YHGK +D F PFYK ML+K TL D+ES+D E+YNS+ WI EN+ E L+L
Sbjct: 989 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLR 1046
Query: 672 FIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV 731
FI D E+ G+ HELK GG I VT +NK+EYI L+ WRF +++Q AF +GF E+
Sbjct: 1047 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 1106
Query: 732 APLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEK 790
P + ++ FDE ELEL++CG+ ++D++DW++ T Y++ Y+ N + IQWFW+ V MD+EK
Sbjct: 1107 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 1166
Query: 791 RIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSY 850
RIRLLQFVTGT R+P+ GFAEL GSNGPQ F +++ G LPR+HTCFNRLDLPPY+S+
Sbjct: 1167 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 1226
Query: 851 EQLREKLLYAIEETEGF 867
E+L +KL AIE T+GF
Sbjct: 1227 EELWDKLQMAIENTQGF 1243
Score = 91.3 bits (225), Expect = 4e-18
Identities = 47/119 (39%), Positives = 58/119 (48%), Gaps = 22/119 (18%)
Query: 270 TSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWE 329
TS + A P S SG Q + LP GWE R PNGR +++DHNTKTTTWE
Sbjct: 738 TSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE 797
Query: 330 ----------------------RPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYV 366
PLPPGWE+RT GR +Y++HN + T W+ P E V
Sbjct: 798 DPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 856
Score = 75.5 bits (184), Expect = 2e-13
Identities = 66/249 (26%), Positives = 96/249 (38%), Gaps = 60/249 (24%)
Query: 276 ATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG 335
A+ EG+ + S + ++ GW + P+ + + PLPPG
Sbjct: 489 ASGNEGKVDNLSRDSNRDCTNELSNSCKPGWVVLDQPDAACHLQQQQEPS-----PLPPG 543
Query: 336 WEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSS 395
WE+R D GR YYV+H +R T W+RPT + N ++ QLQ A + F+ R
Sbjct: 544 WEERQDILGRTYYVNHESRRTQWKRPTPQ--DNLTDAENGNIQLQ-AQRAFTTRRQISEE 600
Query: 396 SASTDHDPLGPLPPGWE-KRQDNGRVY--------------------------------- 421
+ S D+ WE R+D +Y
Sbjct: 601 TESVDNRESS---ENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGN 657
Query: 422 --------YVNHNTRT------TQWEDPRTQGMI-QEPALPPGWEMKYTSEGVRYFVDHN 466
NH++R T E P ++ LPPGWE K G Y+VDHN
Sbjct: 658 SAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHN 717
Query: 467 TRTTTFKDP 475
+RTTT+ P
Sbjct: 718 SRTTTWTKP 726
Score = 39.3 bits (90), Expect = 0.016
Identities = 18/37 (48%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 442 QEPA-LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 477
QEP+ LPPGWE + G Y+V+H +R T +K P P
Sbjct: 535 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTP 571
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 513 bits (1321), Expect = e-145
Identities = 299/732 (40%), Positives = 414/732 (56%), Gaps = 82/732 (11%)
Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 248 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 306
Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQ 308
++ + L +TP+ N GE+ S+ ++ + ++ A EQ
Sbjct: 307 ----LSEELSRRLQITPDSN------------GEQFSSLIQREPSSRLRSCSVTDAVAEQ 350
Query: 309 RELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRN 368
LP V YV H T LP GWE+R D +GR YYV+HN RTTTW RP + +
Sbjct: 351 GHLPPPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 403
Query: 369 YEQWQSQRNQ------------------------LQGAMQHFSQRFLY------QSSSAS 398
+ + L+GA +R + QS S
Sbjct: 404 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPS 463
Query: 399 TDHDPLGP-------LPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQGMIQEPA----- 445
+ P LPPGWE R NGR ++++HNT+TT WEDPR + + +
Sbjct: 464 PYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLN 523
Query: 446 ------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY 499
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY
Sbjct: 524 PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKY 581
Query: 500 HQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYG 557
FR A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYG
Sbjct: 582 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 641
Query: 558 GIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMAL 616
G+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A+
Sbjct: 642 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 701
Query: 617 YHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDM 676
+HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D
Sbjct: 702 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDE 759
Query: 677 EILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEW 736
E G+ +LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++
Sbjct: 760 ENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDL 819
Query: 737 LRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLL 795
++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLL
Sbjct: 820 IKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLL 879
Query: 796 QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLRE 855
QFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LRE
Sbjct: 880 QFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLRE 939
Query: 856 KLLYAIEETEGF 867
KLL A+E +GF
Sbjct: 940 KLLMAVENAQGF 951
Score = 87.0 bits (214), Expect = 7e-17
Identities = 65/226 (28%), Positives = 92/226 (40%), Gaps = 35/226 (15%)
Query: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220
R S T E H PP + + G S A RT +R
Sbjct: 339 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 398
Query: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276
+ G SG A + N +P+ ++SP +APL +P ++
Sbjct: 399 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 454
Query: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP----- 331
+ + +PS + + P LP GWE R PNGR +++DHNTKTTTWE P
Sbjct: 455 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFP 513
Query: 332 ----------------LPPGWEKRTDPRGRFYYVDHNTRTTTWQRP 361
LPPGWE+R GR +Y+DHN++ T W+ P
Sbjct: 514 VHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 559
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 168 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 217
Query: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 218 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 274
Score = 57.0 bits (136), Expect = 7e-08
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 41/228 (17%)
Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKR 339
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 178 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 232
Query: 340 TDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSAST 399
+D R + R +R +E + E S+ + + S+ S
Sbjct: 233 SDNNIRQINQEAAHRRFRSRRHISE---DLEPEPSEGGDVPEPWETISEEVNIAGDSLGL 289
Query: 400 DHDPLGPLPPG-----WEKRQDNGRVYYVNHNTRTTQW-----EDPRT------------ 437
P P PG E ++ R + ++ Q+ +P +
Sbjct: 290 ALPP-PPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVA 348
Query: 438 -QGMIQEPA---------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
QG + P+ LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 349 EQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 396
Score = 42.7 bits (99), Expect = 0.001
Identities = 51/223 (22%), Positives = 86/223 (38%), Gaps = 55/223 (24%)
Query: 316 VYYVDHN-----TKTTTWERPLPPGWEK----RTDPRGR---FYYVDHNTRTTT------ 357
+Y D N +T T ++ L P W + R +P F D N T
Sbjct: 49 LYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQV 108
Query: 358 --------WQRPTAEYVRNYEQW----QSQRNQLQGAMQHFSQRFLYQSSSASTDH---D 402
+ PT E ++ + +S +++++G ++ + Y + D D
Sbjct: 109 DVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLR---LKMAYMPKNGGQDEENSD 165
Query: 403 PLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYF 462
+ GWE V+ N +Q ++ + P LPPGWE K + G Y+
Sbjct: 166 QRDDMEHGWE---------VVDSNDSASQHQEE-----LPPPPLPPGWEEKVDNLGRTYY 211
Query: 463 VDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWKYH 500
V+HN RTT + D ++ +Q + A R FR + H
Sbjct: 212 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 254
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 513 bits (1321), Expect = e-145
Identities = 299/732 (40%), Positives = 414/732 (56%), Gaps = 82/732 (11%)
Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185
Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQ 308
++ + L +TP+ N GE+ S+ ++ + ++ A EQ
Sbjct: 186 ----LSEELSRRLQITPDSN------------GEQFSSLIQREPSSRLRSCSVTDAVAEQ 229
Query: 309 RELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRN 368
LP V YV H T LP GWE+R D +GR YYV+HN RTTTW RP + +
Sbjct: 230 GHLPPPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 282
Query: 369 YEQWQSQRNQ------------------------LQGAMQHFSQRFLY------QSSSAS 398
+ + L+GA +R + QS S
Sbjct: 283 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPS 342
Query: 399 TDHDPLGP-------LPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQGMIQEPA----- 445
+ P LPPGWE R NGR ++++HNT+TT WEDPR + + +
Sbjct: 343 PYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLN 402
Query: 446 ------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY 499
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY
Sbjct: 403 PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKY 460
Query: 500 HQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYG 557
FR A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYG
Sbjct: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520
Query: 558 GIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMAL 616
G+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A+
Sbjct: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580
Query: 617 YHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDM 676
+HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D
Sbjct: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDE 638
Query: 677 EILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEW 736
E G+ +LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++
Sbjct: 639 ENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDL 698
Query: 737 LRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLL 795
++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLL
Sbjct: 699 IKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLL 758
Query: 796 QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLRE 855
QFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LRE
Sbjct: 759 QFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLRE 818
Query: 856 KLLYAIEETEGF 867
KLL A+E +GF
Sbjct: 819 KLLMAVENAQGF 830
Score = 87.0 bits (214), Expect = 7e-17
Identities = 65/226 (28%), Positives = 92/226 (40%), Gaps = 35/226 (15%)
Query: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220
R S T E H PP + + G S A RT +R
Sbjct: 218 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 277
Query: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276
+ G SG A + N +P+ ++SP +APL +P ++
Sbjct: 278 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 333
Query: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP----- 331
+ + +PS + + P LP GWE R PNGR +++DHNTKTTTWE P
Sbjct: 334 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFP 392
Query: 332 ----------------LPPGWEKRTDPRGRFYYVDHNTRTTTWQRP 361
LPPGWE+R GR +Y+DHN++ T W+ P
Sbjct: 393 VHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 438
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 47 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 96
Query: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 97 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 153
Score = 59.3 bits (142), Expect = 1e-08
Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 351 HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD---PLGPL 407
H +R + R Y+ + + + M+H + + S+ +++ H P PL
Sbjct: 17 HKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWE--VVDSNDSASQHQEELPPPPL 74
Query: 408 PPGWEKRQDN-GRVYYVNHNTRTTQWEDPRTQGMIQE 443
PPGWE++ DN GR YYVNHN RTTQW P + E
Sbjct: 75 PPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Score = 57.0 bits (136), Expect = 7e-08
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 41/228 (17%)
Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKR 339
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 57 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Query: 340 TDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSAST 399
+D R + R +R +E + E S+ + + S+ S
Sbjct: 112 SDNNIRQINQEAAHRRFRSRRHISE---DLEPEPSEGGDVPEPWETISEEVNIAGDSLGL 168
Query: 400 DHDPLGPLPPG-----WEKRQDNGRVYYVNHNTRTTQW-----EDPRT------------ 437
P P PG E ++ R + ++ Q+ +P +
Sbjct: 169 ALPP-PPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVA 227
Query: 438 -QGMIQEPA---------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
QG + P+ LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 228 EQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 5/68 (7%)
Query: 438 QGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYD 492
Q + P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A
Sbjct: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAH 125
Query: 493 RSFRWKYH 500
R FR + H
Sbjct: 126 RRFRSRRH 133
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 513 bits (1321), Expect = e-145
Identities = 299/732 (40%), Positives = 414/732 (56%), Gaps = 82/732 (11%)
Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185
Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQ 308
++ + L +TP+ N GE+ S+ ++ + ++ A EQ
Sbjct: 186 ----LSEELSRRLQITPDSN------------GEQFSSLIQREPSSRLRSCSVTDAVAEQ 229
Query: 309 RELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRN 368
LP V YV H T LP GWE+R D +GR YYV+HN RTTTW RP + +
Sbjct: 230 GHLPPPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 282
Query: 369 YEQWQSQRNQ------------------------LQGAMQHFSQRFLY------QSSSAS 398
+ + L+GA +R + QS S
Sbjct: 283 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPS 342
Query: 399 TDHDPLGP-------LPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQGMIQEPA----- 445
+ P LPPGWE R NGR ++++HNT+TT WEDPR + + +
Sbjct: 343 PYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLN 402
Query: 446 ------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY 499
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY
Sbjct: 403 PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKY 460
Query: 500 HQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYG 557
FR A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYG
Sbjct: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520
Query: 558 GIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMAL 616
G+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A+
Sbjct: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580
Query: 617 YHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDM 676
+HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D
Sbjct: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDE 638
Query: 677 EILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEW 736
E G+ +LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++
Sbjct: 639 ENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDL 698
Query: 737 LRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLL 795
++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLL
Sbjct: 699 IKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLL 758
Query: 796 QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLRE 855
QFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LRE
Sbjct: 759 QFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLRE 818
Query: 856 KLLYAIEETEGF 867
KLL A+E +GF
Sbjct: 819 KLLMAVENAQGF 830
Score = 87.0 bits (214), Expect = 7e-17
Identities = 65/226 (28%), Positives = 92/226 (40%), Gaps = 35/226 (15%)
Query: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220
R S T E H PP + + G S A RT +R
Sbjct: 218 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 277
Query: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276
+ G SG A + N +P+ ++SP +APL +P ++
Sbjct: 278 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 333
Query: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP----- 331
+ + +PS + + P LP GWE R PNGR +++DHNTKTTTWE P
Sbjct: 334 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFP 392
Query: 332 ----------------LPPGWEKRTDPRGRFYYVDHNTRTTTWQRP 361
LPPGWE+R GR +Y+DHN++ T W+ P
Sbjct: 393 VHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 438
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 47 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 96
Query: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 97 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 153
Score = 59.3 bits (142), Expect = 1e-08
Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 351 HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD---PLGPL 407
H +R + R Y+ + + + M+H + + S+ +++ H P PL
Sbjct: 17 HKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWE--VVDSNDSASQHQEELPPPPL 74
Query: 408 PPGWEKRQDN-GRVYYVNHNTRTTQWEDPRTQGMIQE 443
PPGWE++ DN GR YYVNHN RTTQW P + E
Sbjct: 75 PPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Score = 57.0 bits (136), Expect = 7e-08
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 41/228 (17%)
Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKR 339
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 57 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Query: 340 TDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSAST 399
+D R + R +R +E + E S+ + + S+ S
Sbjct: 112 SDNNIRQINQEAAHRRFRSRRHISE---DLEPEPSEGGDVPEPWETISEEVNIAGDSLGL 168
Query: 400 DHDPLGPLPPG-----WEKRQDNGRVYYVNHNTRTTQW-----EDPRT------------ 437
P P PG E ++ R + ++ Q+ +P +
Sbjct: 169 ALPP-PPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVA 227
Query: 438 -QGMIQEPA---------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
QG + P+ LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 228 EQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 5/68 (7%)
Query: 438 QGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYD 492
Q + P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A
Sbjct: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAH 125
Query: 493 RSFRWKYH 500
R FR + H
Sbjct: 126 RRFRSRRH 133
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 513 bits (1321), Expect = e-145
Identities = 299/732 (40%), Positives = 414/732 (56%), Gaps = 82/732 (11%)
Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 240 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 298
Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQ 308
++ + L +TP+ N GE+ S+ ++ + ++ A EQ
Sbjct: 299 ----LSEELSRRLQITPDSN------------GEQFSSLIQREPSSRLRSCSVTDAVAEQ 342
Query: 309 RELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRN 368
LP V YV H T LP GWE+R D +GR YYV+HN RTTTW RP + +
Sbjct: 343 GHLPPPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 395
Query: 369 YEQWQSQRNQ------------------------LQGAMQHFSQRFLY------QSSSAS 398
+ + L+GA +R + QS S
Sbjct: 396 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPS 455
Query: 399 TDHDPLGP-------LPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQGMIQEPA----- 445
+ P LPPGWE R NGR ++++HNT+TT WEDPR + + +
Sbjct: 456 PYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLN 515
Query: 446 ------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY 499
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY
Sbjct: 516 PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKY 573
Query: 500 HQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYG 557
FR A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYG
Sbjct: 574 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 633
Query: 558 GIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMAL 616
G+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A+
Sbjct: 634 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 693
Query: 617 YHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDM 676
+HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D
Sbjct: 694 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDE 751
Query: 677 EILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEW 736
E G+ +LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++
Sbjct: 752 ENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDL 811
Query: 737 LRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLL 795
++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLL
Sbjct: 812 IKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLL 871
Query: 796 QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLRE 855
QFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LRE
Sbjct: 872 QFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLRE 931
Query: 856 KLLYAIEETEGF 867
KLL A+E +GF
Sbjct: 932 KLLMAVENAQGF 943
Score = 87.0 bits (214), Expect = 7e-17
Identities = 65/226 (28%), Positives = 92/226 (40%), Gaps = 35/226 (15%)
Query: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220
R S T E H PP + + G S A RT +R
Sbjct: 331 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 390
Query: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276
+ G SG A + N +P+ ++SP +APL +P ++
Sbjct: 391 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 446
Query: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP----- 331
+ + +PS + + P LP GWE R PNGR +++DHNTKTTTWE P
Sbjct: 447 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFP 505
Query: 332 ----------------LPPGWEKRTDPRGRFYYVDHNTRTTTWQRP 361
LPPGWE+R GR +Y+DHN++ T W+ P
Sbjct: 506 VHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 551
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 160 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 209
Query: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 210 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 266
Score = 57.0 bits (136), Expect = 7e-08
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 41/228 (17%)
Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKR 339
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 170 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 224
Query: 340 TDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSAST 399
+D R + R +R +E + E S+ + + S+ S
Sbjct: 225 SDNNIRQINQEAAHRRFRSRRHISE---DLEPEPSEGGDVPEPWETISEEVNIAGDSLGL 281
Query: 400 DHDPLGPLPPG-----WEKRQDNGRVYYVNHNTRTTQW-----EDPRT------------ 437
P P PG E ++ R + ++ Q+ +P +
Sbjct: 282 ALPP-PPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVA 340
Query: 438 -QGMIQEPA---------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
QG + P+ LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 341 EQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 388
Score = 42.7 bits (99), Expect = 0.001
Identities = 51/223 (22%), Positives = 86/223 (38%), Gaps = 55/223 (24%)
Query: 316 VYYVDHN-----TKTTTWERPLPPGWEK----RTDPRGR---FYYVDHNTRTTT------ 357
+Y D N +T T ++ L P W + R +P F D N T
Sbjct: 41 LYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQV 100
Query: 358 --------WQRPTAEYVRNYEQW----QSQRNQLQGAMQHFSQRFLYQSSSASTDH---D 402
+ PT E ++ + +S +++++G ++ + Y + D D
Sbjct: 101 DVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLR---LKMAYMPKNGGQDEENSD 157
Query: 403 PLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYF 462
+ GWE V+ N +Q ++ + P LPPGWE K + G Y+
Sbjct: 158 QRDDMEHGWE---------VVDSNDSASQHQEE-----LPPPPLPPGWEEKVDNLGRTYY 203
Query: 463 VDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWKYH 500
V+HN RTT + D ++ +Q + A R FR + H
Sbjct: 204 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 246
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 508 bits (1307), Expect = e-143
Identities = 302/744 (40%), Positives = 415/744 (55%), Gaps = 86/744 (11%)
Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185
Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTS--GTQQLPAAAQA----PDAL 302
++ + L +TP+ N + EPS+ A A+ P +
Sbjct: 186 ----LSEELSRRLQITPDSNGEQFSSLIQ----REPSSRLRSCSVTDAVAEQGHLPPPSA 237
Query: 303 PAGWEQR------ELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTT 356
PAG + E P V YV H T LP GWE+R D +GR YYV+HN RTT
Sbjct: 238 PAGRARSSTVTGGEEPTPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTT 290
Query: 357 TWQRPTAEYVRNYEQWQSQRNQ------------------------LQGAMQHFSQRFLY 392
TW RP + + + + L+GA +R +
Sbjct: 291 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK 350
Query: 393 ------QSSSASTDHDPLGP-------LPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQ 438
QS S + P LPPGWE R NGR ++++HNT+TT WEDPR +
Sbjct: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
Query: 439 GMIQEPA-----------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGS 487
+ + LPPGWE + +G +++DHN++ T ++DPR ++ G
Sbjct: 411 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGP 468
Query: 488 PGAYDRSFRWKYHQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLY 545
Y R F+ KY FR A +P+ ++ + R +FE+S+++IM++K D L+ RL+
Sbjct: 469 AVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLW 528
Query: 546 IIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTY 604
I E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+Y
Sbjct: 529 IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY 588
Query: 605 FRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLE 664
F FIGR +A++HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+
Sbjct: 589 FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPT 648
Query: 665 ECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAF 724
E L+L F D E G+ +LK G I VT ENK EYI L+ WRF V++Q AF
Sbjct: 649 E--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAF 706
Query: 725 LDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVV 783
L+GF E+ P++ ++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V
Sbjct: 707 LEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAV 766
Query: 784 KEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLD 843
MD EKRIRLLQFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLD
Sbjct: 767 LLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLD 826
Query: 844 LPPYKSYEQLREKLLYAIEETEGF 867
LPPY+++E LREKLL A+E +GF
Sbjct: 827 LPPYETFEDLREKLLMAVENAQGF 850
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 47 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 96
Query: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 97 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 153
Score = 59.3 bits (142), Expect = 1e-08
Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 351 HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD---PLGPL 407
H +R + R Y+ + + + M+H + + S+ +++ H P PL
Sbjct: 17 HKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWE--VVDSNDSASQHQEELPPPPL 74
Query: 408 PPGWEKRQDN-GRVYYVNHNTRTTQWEDPRTQGMIQE 443
PPGWE++ DN GR YYVNHN RTTQW P + E
Sbjct: 75 PPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)
Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 57 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 5/68 (7%)
Query: 438 QGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYD 492
Q + P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A
Sbjct: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAH 125
Query: 493 RSFRWKYH 500
R FR + H
Sbjct: 126 RRFRSRRH 133
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 508 bits (1307), Expect = e-143
Identities = 302/744 (40%), Positives = 415/744 (55%), Gaps = 86/744 (11%)
Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 240 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 298
Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTS--GTQQLPAAAQA----PDAL 302
++ + L +TP+ N + EPS+ A A+ P +
Sbjct: 299 ----LSEELSRRLQITPDSNGEQFSSLIQ----REPSSRLRSCSVTDAVAEQGHLPPPSA 350
Query: 303 PAGWEQR------ELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTT 356
PAG + E P V YV H T LP GWE+R D +GR YYV+HN RTT
Sbjct: 351 PAGRARSSTVTGGEEPTPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTT 403
Query: 357 TWQRPTAEYVRNYEQWQSQRNQ------------------------LQGAMQHFSQRFLY 392
TW RP + + + + L+GA +R +
Sbjct: 404 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK 463
Query: 393 ------QSSSASTDHDPLGP-------LPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQ 438
QS S + P LPPGWE R NGR ++++HNT+TT WEDPR +
Sbjct: 464 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 523
Query: 439 GMIQEPA-----------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGS 487
+ + LPPGWE + +G +++DHN++ T ++DPR ++ G
Sbjct: 524 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGP 581
Query: 488 PGAYDRSFRWKYHQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLY 545
Y R F+ KY FR A +P+ ++ + R +FE+S+++IM++K D L+ RL+
Sbjct: 582 AVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLW 641
Query: 546 IIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTY 604
I E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+Y
Sbjct: 642 IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY 701
Query: 605 FRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLE 664
F FIGR +A++HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+
Sbjct: 702 FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPT 761
Query: 665 ECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAF 724
E L+L F D E G+ +LK G I VT ENK EYI L+ WRF V++Q AF
Sbjct: 762 E--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAF 819
Query: 725 LDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVV 783
L+GF E+ P++ ++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V
Sbjct: 820 LEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAV 879
Query: 784 KEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLD 843
MD EKRIRLLQFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLD
Sbjct: 880 LLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLD 939
Query: 844 LPPYKSYEQLREKLLYAIEETEGF 867
LPPY+++E LREKLL A+E +GF
Sbjct: 940 LPPYETFEDLREKLLMAVENAQGF 963
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 160 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 209
Query: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 210 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 266
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)
Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 170 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 42.7 bits (99), Expect = 0.001
Identities = 51/223 (22%), Positives = 86/223 (38%), Gaps = 55/223 (24%)
Query: 316 VYYVDHN-----TKTTTWERPLPPGWEK----RTDPRGR---FYYVDHNTRTTT------ 357
+Y D N +T T ++ L P W + R +P F D N T
Sbjct: 41 LYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQV 100
Query: 358 --------WQRPTAEYVRNYEQW----QSQRNQLQGAMQHFSQRFLYQSSSASTDH---D 402
+ PT E ++ + +S +++++G ++ + Y + D D
Sbjct: 101 DVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLR---LKMAYMPKNGGQDEENSD 157
Query: 403 PLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYF 462
+ GWE V+ N +Q ++ + P LPPGWE K + G Y+
Sbjct: 158 QRDDMEHGWE---------VVDSNDSASQHQEE-----LPPPPLPPGWEEKVDNLGRTYY 203
Query: 463 VDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWKYH 500
V+HN RTT + D ++ +Q + A R FR + H
Sbjct: 204 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 246
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 508 bits (1307), Expect = e-143
Identities = 302/744 (40%), Positives = 415/744 (55%), Gaps = 86/744 (11%)
Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 248 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 306
Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTS--GTQQLPAAAQA----PDAL 302
++ + L +TP+ N + EPS+ A A+ P +
Sbjct: 307 ----LSEELSRRLQITPDSNGEQFSSLIQ----REPSSRLRSCSVTDAVAEQGHLPPPSA 358
Query: 303 PAGWEQR------ELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTT 356
PAG + E P V YV H T LP GWE+R D +GR YYV+HN RTT
Sbjct: 359 PAGRARSSTVTGGEEPTPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTT 411
Query: 357 TWQRPTAEYVRNYEQWQSQRNQ------------------------LQGAMQHFSQRFLY 392
TW RP + + + + L+GA +R +
Sbjct: 412 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK 471
Query: 393 ------QSSSASTDHDPLGP-------LPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQ 438
QS S + P LPPGWE R NGR ++++HNT+TT WEDPR +
Sbjct: 472 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 531
Query: 439 GMIQEPA-----------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGS 487
+ + LPPGWE + +G +++DHN++ T ++DPR ++ G
Sbjct: 532 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGP 589
Query: 488 PGAYDRSFRWKYHQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLY 545
Y R F+ KY FR A +P+ ++ + R +FE+S+++IM++K D L+ RL+
Sbjct: 590 AVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLW 649
Query: 546 IIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTY 604
I E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+Y
Sbjct: 650 IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY 709
Query: 605 FRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLE 664
F FIGR +A++HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+
Sbjct: 710 FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPT 769
Query: 665 ECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAF 724
E L+L F D E G+ +LK G I VT ENK EYI L+ WRF V++Q AF
Sbjct: 770 E--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAF 827
Query: 725 LDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVV 783
L+GF E+ P++ ++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V
Sbjct: 828 LEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAV 887
Query: 784 KEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLD 843
MD EKRIRLLQFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLD
Sbjct: 888 LLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLD 947
Query: 844 LPPYKSYEQLREKLLYAIEETEGF 867
LPPY+++E LREKLL A+E +GF
Sbjct: 948 LPPYETFEDLREKLLMAVENAQGF 971
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 168 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 217
Query: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 218 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 274
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)
Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 178 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 42.7 bits (99), Expect = 0.001
Identities = 51/223 (22%), Positives = 86/223 (38%), Gaps = 55/223 (24%)
Query: 316 VYYVDHN-----TKTTTWERPLPPGWEK----RTDPRGR---FYYVDHNTRTTT------ 357
+Y D N +T T ++ L P W + R +P F D N T
Sbjct: 49 LYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQV 108
Query: 358 --------WQRPTAEYVRNYEQW----QSQRNQLQGAMQHFSQRFLYQSSSASTDH---D 402
+ PT E ++ + +S +++++G ++ + Y + D D
Sbjct: 109 DVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLR---LKMAYMPKNGGQDEENSD 165
Query: 403 PLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYF 462
+ GWE V+ N +Q ++ + P LPPGWE K + G Y+
Sbjct: 166 QRDDMEHGWE---------VVDSNDSASQHQEE-----LPPPPLPPGWEEKVDNLGRTYY 211
Query: 463 VDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWKYH 500
V+HN RTT + D ++ +Q + A R FR + H
Sbjct: 212 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 254
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 508 bits (1307), Expect = e-143
Identities = 302/744 (40%), Positives = 415/744 (55%), Gaps = 86/744 (11%)
Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185
Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTS--GTQQLPAAAQA----PDAL 302
++ + L +TP+ N + EPS+ A A+ P +
Sbjct: 186 ----LSEELSRRLQITPDSNGEQFSSLIQ----REPSSRLRSCSVTDAVAEQGHLPPPSA 237
Query: 303 PAGWEQR------ELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTT 356
PAG + E P V YV H T LP GWE+R D +GR YYV+HN RTT
Sbjct: 238 PAGRARSSTVTGGEEPTPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTT 290
Query: 357 TWQRPTAEYVRNYEQWQSQRNQ------------------------LQGAMQHFSQRFLY 392
TW RP + + + + L+GA +R +
Sbjct: 291 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK 350
Query: 393 ------QSSSASTDHDPLGP-------LPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQ 438
QS S + P LPPGWE R NGR ++++HNT+TT WEDPR +
Sbjct: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
Query: 439 GMIQEPA-----------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGS 487
+ + LPPGWE + +G +++DHN++ T ++DPR ++ G
Sbjct: 411 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGP 468
Query: 488 PGAYDRSFRWKYHQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLY 545
Y R F+ KY FR A +P+ ++ + R +FE+S+++IM++K D L+ RL+
Sbjct: 469 AVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLW 528
Query: 546 IIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTY 604
I E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+Y
Sbjct: 529 IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY 588
Query: 605 FRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLE 664
F FIGR +A++HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+
Sbjct: 589 FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPT 648
Query: 665 ECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAF 724
E L+L F D E G+ +LK G I VT ENK EYI L+ WRF V++Q AF
Sbjct: 649 E--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAF 706
Query: 725 LDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVV 783
L+GF E+ P++ ++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V
Sbjct: 707 LEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAV 766
Query: 784 KEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLD 843
MD EKRIRLLQFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLD
Sbjct: 767 LLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLD 826
Query: 844 LPPYKSYEQLREKLLYAIEETEGF 867
LPPY+++E LREKLL A+E +GF
Sbjct: 827 LPPYETFEDLREKLLMAVENAQGF 850
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 47 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 96
Query: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 97 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 153
Score = 59.3 bits (142), Expect = 1e-08
Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 351 HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD---PLGPL 407
H +R + R Y+ + + + M+H + + S+ +++ H P PL
Sbjct: 17 HKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWE--VVDSNDSASQHQEELPPPPL 74
Query: 408 PPGWEKRQDN-GRVYYVNHNTRTTQWEDPRTQGMIQE 443
PPGWE++ DN GR YYVNHN RTTQW P + E
Sbjct: 75 PPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)
Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 57 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 5/68 (7%)
Query: 438 QGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYD 492
Q + P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A
Sbjct: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAH 125
Query: 493 RSFRWKYH 500
R FR + H
Sbjct: 126 RRFRSRRH 133
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 508 bits (1307), Expect = e-143
Identities = 302/744 (40%), Positives = 415/744 (55%), Gaps = 86/744 (11%)
Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185
Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTS--GTQQLPAAAQA----PDAL 302
++ + L +TP+ N + EPS+ A A+ P +
Sbjct: 186 ----LSEELSRRLQITPDSNGEQFSSLIQ----REPSSRLRSCSVTDAVAEQGHLPPPSA 237
Query: 303 PAGWEQR------ELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTT 356
PAG + E P V YV H T LP GWE+R D +GR YYV+HN RTT
Sbjct: 238 PAGRARSSTVTGGEEPTPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTT 290
Query: 357 TWQRPTAEYVRNYEQWQSQRNQ------------------------LQGAMQHFSQRFLY 392
TW RP + + + + L+GA +R +
Sbjct: 291 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK 350
Query: 393 ------QSSSASTDHDPLGP-------LPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQ 438
QS S + P LPPGWE R NGR ++++HNT+TT WEDPR +
Sbjct: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
Query: 439 GMIQEPA-----------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGS 487
+ + LPPGWE + +G +++DHN++ T ++DPR ++ G
Sbjct: 411 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGP 468
Query: 488 PGAYDRSFRWKYHQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLY 545
Y R F+ KY FR A +P+ ++ + R +FE+S+++IM++K D L+ RL+
Sbjct: 469 AVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLW 528
Query: 546 IIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTY 604
I E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+Y
Sbjct: 529 IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY 588
Query: 605 FRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLE 664
F FIGR +A++HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+
Sbjct: 589 FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPT 648
Query: 665 ECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAF 724
E L+L F D E G+ +LK G I VT ENK EYI L+ WRF V++Q AF
Sbjct: 649 E--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAF 706
Query: 725 LDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVV 783
L+GF E+ P++ ++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V
Sbjct: 707 LEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAV 766
Query: 784 KEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLD 843
MD EKRIRLLQFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLD
Sbjct: 767 LLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLD 826
Query: 844 LPPYKSYEQLREKLLYAIEETEGF 867
LPPY+++E LREKLL A+E +GF
Sbjct: 827 LPPYETFEDLREKLLMAVENAQGF 850
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 47 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 96
Query: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 97 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 153
Score = 59.3 bits (142), Expect = 1e-08
Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 351 HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD---PLGPL 407
H +R + R Y+ + + + M+H + + S+ +++ H P PL
Sbjct: 17 HKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWE--VVDSNDSASQHQEELPPPPL 74
Query: 408 PPGWEKRQDN-GRVYYVNHNTRTTQWEDPRTQGMIQE 443
PPGWE++ DN GR YYVNHN RTTQW P + E
Sbjct: 75 PPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)
Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 57 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 5/68 (7%)
Query: 438 QGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYD 492
Q + P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A
Sbjct: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAH 125
Query: 493 RSFRWKYH 500
R FR + H
Sbjct: 126 RRFRSRRH 133
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 474 bits (1221), Expect = e-133
Identities = 260/597 (43%), Positives = 355/597 (59%), Gaps = 57/597 (9%)
Query: 328 WERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPT---AEYV---RNYEQWQSQRNQLQG 381
++ LP GWE+R GR Y++H TRTT W+RPT +EY R + + + G
Sbjct: 155 FDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISG 214
Query: 382 A---------------MQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQ-DNGRVYYVNH 425
+ SQR S P LP G+E+R G+VY+++
Sbjct: 215 TNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPP--DLPEGYEQRTTQQGQVYFLHT 272
Query: 426 NTRTTQWEDPRTQGMIQE------PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGF 479
T + W DPR + LPPGWE++ T+ G YFVDHN RTT F DPR
Sbjct: 273 QTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSA 332
Query: 480 E------------------------SGTKQGSPGAYDRSFRWKYHQFR-FLCHSNALPSH 514
T+ + Y R K R L H
Sbjct: 333 NLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGH 392
Query: 515 VKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNP 574
+I VSR+ +FE+S++Q+M M+P DL +RL I RGEEGLDYGG+AREW +LLSHE+LNP
Sbjct: 393 CRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNP 452
Query: 575 MYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRM 634
Y LF+Y+ + Y LQINP S++NP+HL+YF F+GR + MA++HG +ID GFTLPFYK++
Sbjct: 453 YYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQL 512
Query: 635 LNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESI 694
L K TL D+E +DP+ +NS+VWI EN++ L+ F + G++ HELK G+SI
Sbjct: 513 LGKSITLDDMELVDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSI 571
Query: 695 RVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQE 754
V EENK+EY+ L +WRF RG+E Q A GFNEV P L+ FDEKELEL++CG+ +
Sbjct: 572 PVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGK 631
Query: 755 IDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIG 814
ID++DW+ +T +H T +S ++WFW+ V+ D E+R RLLQFVTG+ R+P+ GF L G
Sbjct: 632 IDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQG 691
Query: 815 SNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
+ GP+ F I ++ T LP++HTCFNR+D+PPY+SYE+L EKLL AIEET GF E
Sbjct: 692 AAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 459 bits (1182), Expect = e-129
Identities = 242/554 (43%), Positives = 339/554 (61%), Gaps = 47/554 (8%)
Query: 332 LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFL 391
LP G+E+RT +G+ Y++ T +TW P + S + G F FL
Sbjct: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDP---------RIPSPSGTIPGGDAAFLYEFL 286
Query: 392 YQSSSA------STDHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEP 444
Q ++ S + D LGPLPPGWE R +GR+Y+V+HN RTTQ+ DPR
Sbjct: 287 LQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPR-------- 338
Query: 445 ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRF 504
+ + ++H + P P G+ + R R + +
Sbjct: 339 --------------LHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKV 384
Query: 505 LCHSNAL----PSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIA 560
L H +L H +I VSR+ +FE+S++QIM M+P DL++RL + RGEEGLDYGG+A
Sbjct: 385 LRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVA 444
Query: 561 REWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK 620
REW +LL HE+LNP Y LF+Y+ N Y LQINP SSINPDHL+YF F+GR + +A++HG
Sbjct: 445 REWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGH 504
Query: 621 FIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILG 680
+I+ GFT+PFYK++L K L DLES+DPE + S+VWI EN++ L+ F + G
Sbjct: 505 YINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFG 563
Query: 681 KVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYF 740
++ HELK G ++ VTEENK+EY+ L +WRF RG+E Q A GFNE+ P L+ F
Sbjct: 564 RILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPF 623
Query: 741 DEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTG 800
D+KELEL++ G+ +ID++DW+ +T +H +S ++WFWQ V+ D E+R RLLQFVTG
Sbjct: 624 DQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTG 683
Query: 801 TCRLPVGGFAELIGSN---GPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREK 856
+ R+P+ GF L GS GP+ F I + T LP++HTCFNR+D+PPY+SYE+L EK
Sbjct: 684 STRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEK 743
Query: 857 LLYAIEETEGFGQE 870
LL A+EET GF E
Sbjct: 744 LLTAVEETCGFAVE 757
Score = 61.2 bits (147), Expect = 4e-09
Identities = 52/191 (27%), Positives = 71/191 (37%), Gaps = 67/191 (35%)
Query: 246 EEPSVVGVTSPPAAPLSV---TPNPNTTSLPAPA---------TPAEGEE--------PS 285
E V S P PLS P P T S A A +P++ + P
Sbjct: 157 ENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPD 216
Query: 286 TSGTQQLPA----AAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP---------- 331
G+ Q P Q+P+ LP G+EQR G+VY++ T +TW P
Sbjct: 217 VRGSLQTPQNRPHGHQSPE-LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIP 275
Query: 332 --------------------------------LPPGWEKRTDPRGRFYYVDHNTRTTTWQ 359
LPPGWE R+ GR Y+VDHN RTT +
Sbjct: 276 GGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFT 335
Query: 360 RPTAEYVRNYE 370
P ++ N++
Sbjct: 336 DPRLHHIMNHQ 346
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 447 bits (1149), Expect = e-125
Identities = 231/497 (46%), Positives = 316/497 (63%), Gaps = 34/497 (6%)
Query: 407 LPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEP------ALPPGWEMKYTSEGV 459
LP G+E+R G+VY+++ T + W DPR + LPPGWE++ T G
Sbjct: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGR 295
Query: 460 RYFVDHNTRTTTFKDPR------------------PGFESGTKQGSPGAYDRSFRWKYHQ 501
YFVDHN RTT F DPR P G+ + R R +
Sbjct: 296 IYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQK 355
Query: 502 FRFLCHSNALPS----HVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYG 557
+ L H +L H +I VSR+ +FE+S++QIM M+P DL++RL + RGEEGLDYG
Sbjct: 356 LKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYG 415
Query: 558 GIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALY 617
G+AREW +LL HE+LNP Y LF+Y+ N Y LQINP SSINPDHL+YF F+GR + +A++
Sbjct: 416 GVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVF 475
Query: 618 HGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDME 677
HG +I+ GFT+PFYK++L K L DLES+DPE + S+VWI EN++ L+ F +
Sbjct: 476 HGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHN 534
Query: 678 ILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWL 737
G++ HELK G ++ VTEENK+EY+ L +WRF RG+E Q A GFNE+ P L
Sbjct: 535 AFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLL 594
Query: 738 RYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQF 797
+ FD+KELEL++ G+ +ID++DW+ +T +H +S ++WFWQ V+ D E+R RLLQF
Sbjct: 595 KPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQF 654
Query: 798 VTGTCRLPVGGFAELIGSN---GPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQL 853
VTG+ R+P+ GF L GS GP+ F I + T LP++HTCFNR+D+PPY+SYE+L
Sbjct: 655 VTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKL 714
Query: 854 REKLLYAIEETEGFGQE 870
EKLL A+EET GF E
Sbjct: 715 YEKLLTAVEETCGFAVE 731
Score = 71.2 bits (173), Expect = 4e-12
Identities = 52/165 (31%), Positives = 71/165 (43%), Gaps = 41/165 (24%)
Query: 246 EEPSVVGVTSPPAAPLSV---TPNPNTTSLPAPA---------TPAEGEE--------PS 285
E V S P PLS P P T S A A +P++ + P
Sbjct: 157 ENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPD 216
Query: 286 TSGTQQLPA----AAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP---------- 331
G+ Q P Q+P+ LP G+EQR G+VY++ T +TW P
Sbjct: 217 VRGSLQTPQNRPHGHQSPE-LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVN 275
Query: 332 ------LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYE 370
LPPGWE R+ GR Y+VDHN RTT + P ++ N++
Sbjct: 276 CDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQ 320
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 379 bits (972), Expect = e-105
Identities = 230/589 (39%), Positives = 324/589 (55%), Gaps = 53/589 (8%)
Query: 332 LPPGWEKRTDPRGRFYYVDHNTRTTTW---------QRPTAEYVRNYEQWQSQRNQLQGA 382
LP GWE + D +G+ ++VDHN+RTTT+ RPT+ V + QR+ G
Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHR-QHLTRQRSHSAGE 1045
Query: 383 M----QHFSQRFLYQSSS-----ASTDHDPLGPL------------PPGWEKRQDNGRVY 421
+ +H L + SS + + + P+ P +E Q+
Sbjct: 1046 VGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDL 1105
Query: 422 YVNHNTRTTQWEDPRTQGMIQEPALPPGWEMK-----YTSEGVRYFVDHNTRTTTFKDPR 476
NH+ R + + RT+G L ++ + E + Y H ++
Sbjct: 1106 TRNHSLRE-KIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSP 1164
Query: 477 PGFESGTKQGSPGA----------YDRSFRWKYHQFRFLCHSNAL---PSHVKISVSRQT 523
G + Q SPG Y R F K F + P +K+ + R
Sbjct: 1165 RGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDH 1224
Query: 524 LFEDSFQQIMNMKPYDLRR-RLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYA 582
L ED+F QIM DL+R +LY+ GEEGLDY G +RE+FFL+S E+ NP Y LFEY+
Sbjct: 1225 LLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYS 1284
Query: 583 GKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLK 642
+ Y +QI+P S+ +H +FRF GR + +AL H +D FT PFYK +L L
Sbjct: 1285 ANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLS 1344
Query: 643 DLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKE 702
DLE +D EF+ S+ W+K+N++ + L+L F + E+ G++T ELK GG +I VTE+NK+
Sbjct: 1345 DLEYLDEEFHQSLQWMKDNDIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKK 1403
Query: 703 EYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQK 762
EYI + WR RGV +QT++ + GF EV + FD +ELEL++ G EID+SDW+
Sbjct: 1404 EYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRN 1463
Query: 763 STIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKF 821
+T YR Y N I+WFW V+ +NE+R+RLLQFVTGT +P GFA L GSNGP++F
Sbjct: 1464 NTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRF 1523
Query: 822 CIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
C++K GK T LPR+HTCFNRLDLPPY S+ L EKLL A+EET FG E
Sbjct: 1524 CVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
Score = 76.3 bits (186), Expect = 1e-13
Identities = 80/307 (26%), Positives = 124/307 (40%), Gaps = 67/307 (21%)
Query: 213 GARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSL 272
GA + P + G +G A GT AT EE + G + PL P
Sbjct: 745 GAAAAAESPPQEEGSAGEAQGTCEG----ATAQEEGATGGSQANGHQPLRSLP------- 793
Query: 273 PAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP- 331
S Q + + +ALP WE R +GR++YVDH +TTTW+RP
Sbjct: 794 --------------SVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPT 839
Query: 332 LPPGWE--KRTDPRGRFYYVDHN----TRTTTWQRP-------------------TAEYV 366
PP + +R++ + ++ RT T +RP +A++
Sbjct: 840 APPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFR 899
Query: 367 R-NYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNH 425
R N + R+++ +Q +FL + H P + +N + ++
Sbjct: 900 RENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSN----PSAYRMFTNNTCLKHMIT 955
Query: 426 NTRTTQWEDPRTQ------GMI-----QEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKD 474
R R Q G + ++ LP GWEMK+ +G +FVDHN+RTTTF D
Sbjct: 956 KVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFID 1015
Query: 475 PRPGFES 481
PR +S
Sbjct: 1016 PRLPLQS 1022
Score = 62.0 bits (149), Expect = 2e-09
Identities = 68/260 (26%), Positives = 94/260 (36%), Gaps = 30/260 (11%)
Query: 130 SVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVA--PENRHQPPSTNCF 187
S SGG + ++D G+ P+ + P+R S + + PE +
Sbjct: 585 SDASGGSRRAVSETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSS 644
Query: 188 GGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSG------HSGLANGTVNDEPTT 241
S T + S R + + P + Q ++ SG A G+ T
Sbjct: 645 CNESVTTQLSSVDTRCSSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTA 704
Query: 242 ATDPEEPSVVGVTSPPAAPLSVTPNPNTT--------SLPAPATPAEG---EEPSTSGTQ 290
+ P G P A + P+ SL A AE EE S Q
Sbjct: 705 GSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQ 764
Query: 291 QLPAAAQAPDALPAGWEQ-------RELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPR 343
A A + G Q R LP+ R ++ + LPP WE R D
Sbjct: 765 GTCEGATAQEEGATGGSQANGHQPLRSLPSVR----QDVSRYQRVDEALPPNWEARIDSH 820
Query: 344 GRFYYVDHNTRTTTWQRPTA 363
GR +YVDH RTTTWQRPTA
Sbjct: 821 GRIFYVDHVNRTTTWQRPTA 840
Score = 43.9 bits (102), Expect = 7e-04
Identities = 76/335 (22%), Positives = 111/335 (33%), Gaps = 72/335 (21%)
Query: 154 GSALTDGSQLPSRDSSGTAVAPEN-----RHQPPSTNCFGGRSRTHRHSGASARTTPATG 208
GSA GSQ + +SG + R T S + S + + PA
Sbjct: 563 GSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETESLDQGSEPSQVSSETEPSDPART 622
Query: 209 EQSPGARSRHRQPVKNSGHSGL--ANGTVNDEPTT---ATDPEEPSVVGVTSP--PAAPL 261
E A +R G S L A+ + N+ TT + D S+ P PA
Sbjct: 623 ESVSEASTRPE------GESDLECADSSCNESVTTQLSSVDTRCSSLESARFPETPAFSS 676
Query: 262 SVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDH 321
+ + P + PAEG + S LP ++P+G
Sbjct: 677 QEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVV--------------QVPSGEDEGPGA 722
Query: 322 NTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQG 381
+ T + L W++R G A + Q + + QG
Sbjct: 723 ESATVPDQEELGEVWQRRGSLEG-----------------AAAAAESPPQEEGSAGEAQG 765
Query: 382 AMQHFS-QRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGM 440
+ + Q S + H PL LP RQD R V+
Sbjct: 766 TCEGATAQEEGATGGSQANGHQPLRSLP---SVRQDVSRYQRVDE--------------- 807
Query: 441 IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
ALPP WE + S G ++VDH RTTT++ P
Sbjct: 808 ----ALPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 365 bits (936), Expect = e-100
Identities = 228/606 (37%), Positives = 318/606 (52%), Gaps = 56/606 (9%)
Query: 302 LPAGWEQRELPNGRVYYVDHNTKTTTW---ERPLPPG------------WEKRTDPRGRF 346
LP GWE + G+ ++VDHN++ TT+ PL G R+ G
Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA 1079
Query: 347 YYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGP 406
V N + RP V Q Q L A FL Q + +
Sbjct: 1080 SEVSRNRGASLLARPGHSLVAAIRS-QHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPS 1138
Query: 407 LPPGWEKRQDNGRVYYV----NHNTRTTQ-----------WEDPRTQGMIQEPALPPGWE 451
L R+ +++Y+ NH +E+ + + A PG+
Sbjct: 1139 LARNHTLRE---KIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYS 1195
Query: 452 MKYTSEGVRYFVDHNTRTTTFKDPR--PGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSN 509
+ R + P+ PG + + + +P Y R F K F +
Sbjct: 1196 F-------------SPRCSPCSSPQNSPGLQRASAR-APSPYRRDFEAKLRNFYRKLEAK 1241
Query: 510 AL---PSHVKISVSRQTLFEDSFQQIMNMKPYDLRR-RLYIIMRGEEGLDYGGIAREWFF 565
P +K+ + R L E +F Q+M +L+R +LY+ GEEGLDY G +RE+FF
Sbjct: 1242 GFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFF 1301
Query: 566 LLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTG 625
LLS E+ NP Y LFEY+ + Y +QI+P S+ +HL +FRF GR + +AL H +D
Sbjct: 1302 LLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAF 1361
Query: 626 FTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTH 685
FT PFYK +L L DLE +D EF+ S+ W+K+NN+ + L+L F + E+ G+VT
Sbjct: 1362 FTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI-LDLTFTVNEEVFGQVTER 1420
Query: 686 ELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKEL 745
ELK GG + +VTE+NK+EYI + WR RGV +QT+A + GF EV + FD +EL
Sbjct: 1421 ELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDAREL 1480
Query: 746 ELMLCGMQEIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRL 804
EL++ G EID++DW+ +T YR Y I+WFW V+ +NE+R+RLLQFVTGT +
Sbjct: 1481 ELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSV 1540
Query: 805 PVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEET 864
P GFA L GSNG ++FCI+K GK T LPR+HTCFNRLDLPPY SY L EKLL A+EET
Sbjct: 1541 PYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEET 1600
Query: 865 EGFGQE 870
FG E
Sbjct: 1601 STFGLE 1606
Score = 66.6 bits (161), Expect = 9e-11
Identities = 46/138 (33%), Positives = 65/138 (47%), Gaps = 24/138 (17%)
Query: 241 TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSG-TQQLPAAAQAP 299
++ D EE S P + S +P +T+ A P + E + SG ++ P ++P
Sbjct: 734 SSQDDEEEENSAFESVPDSMQSPELDPESTN---GAGPWQDELAAPSGHVERSPEGLESP 790
Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTT--------------TWERPLPPGWEKRTDPRGR 345
A P+ + E P + HN++ T + PLPP WE R D GR
Sbjct: 791 VAGPSNRREGECP------ILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGR 844
Query: 346 FYYVDHNTRTTTWQRPTA 363
+YVDH RTTTWQRPTA
Sbjct: 845 VFYVDHVNRTTTWQRPTA 862
Score = 44.7 bits (104), Expect = 4e-04
Identities = 19/31 (61%), Positives = 23/31 (74%), Gaps = 1/31 (3%)
Query: 406 PLPPGWEKRQDN-GRVYYVNHNTRTTQWEDP 435
PLPP WE R D+ GRV+YV+H RTT W+ P
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
Score = 38.9 bits (89), Expect = 0.021
Identities = 18/35 (51%), Positives = 23/35 (65%), Gaps = 1/35 (2%)
Query: 441 IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
I EP LPP WE + S G ++VDH RTTT++ P
Sbjct: 827 IDEP-LPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
Score = 36.2 bits (82), Expect = 0.14
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 16/71 (22%)
Query: 367 RNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDN-GRVYYVNH 425
RN+E++Q R+ + +F F D LP GWE + D G+ ++V+H
Sbjct: 995 RNFERYQHNRD-----LVNFINMFA----------DTRLELPRGWEIKTDQQGKSFFVDH 1039
Query: 426 NTRTTQWEDPR 436
N+R T + DPR
Sbjct: 1040 NSRATTFIDPR 1050
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 321 bits (823), Expect = 2e-87
Identities = 156/354 (44%), Positives = 227/354 (64%), Gaps = 2/354 (0%)
Query: 517 ISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMY 576
+ V R +FEDS++++ P +++ RLYI+ GEEG D GG+ REW+ ++S E+ NPMY
Sbjct: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMY 4078
Query: 577 CLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLN 636
LF + + INP+S NP+HL+YF+F+GR +A A+Y + ++ FT FYK +L
Sbjct: 4079 ALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILG 4138
Query: 637 KRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRV 696
K D+ES D FY +V++ EN++ G +L F +++ G +LK G +I V
Sbjct: 4139 KSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILV 4198
Query: 697 TEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEID 756
TEENK+EY+ L+ R T + +Q AFL+GF E+ P + F E+ELEL++ G+ ID
Sbjct: 4199 TEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTID 4258
Query: 757 MSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN 816
+ D + +T Y Y NS QIQWFW+ ++ D R + LQFVTGT ++P+ GFA L G N
Sbjct: 4259 IDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMN 4318
Query: 817 GPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEE-TEGFG 868
G QKF I + + T LP +HTCFN+LDLP Y+S+E+LR LL AI+E +EGFG
Sbjct: 4319 GIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFG 4372
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 279 bits (714), Expect = 7e-75
Identities = 147/345 (42%), Positives = 211/345 (61%), Gaps = 4/345 (1%)
Query: 519 VSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 578
V R ++F S + + L++ + + GEEG+ G + REWF +LS+E++NP Y L
Sbjct: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
Query: 579 FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKR 638
F + Q N S +NPDHL YFRF G+ + +AL H + ++ FT FYK +L
Sbjct: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
Query: 639 PTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTE 698
+D+ SIDPE+ ++ WI +N++ + GLEL F + ++ G + LK GG SI VT+
Sbjct: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
Query: 699 ENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMS 758
NK EY+ L+T+ R TR ++ Q AFL GF+ P ++ FDE ELEL+L GM EID+S
Sbjct: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
Query: 759 DWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNG 817
DW K+T Y Y + IQWFW+VV+++ E+R+ LLQFVTG+ R+P GGFA ++G +G
Sbjct: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
Query: 818 PQKFCIDKVG-KETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 861
Q F I V LP S TC N L LP Y S E L+++LL A+
Sbjct: 855 LQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 213 bits (541), Expect = 8e-55
Identities = 128/374 (34%), Positives = 211/374 (56%), Gaps = 23/374 (6%)
Query: 505 LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 561
L L ++++ V R + +D+ + I P DL+++LY+ GE+G+D GG+++
Sbjct: 510 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 569
Query: 562 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 621
E+F L+ E+ NP +F Y ++ NP+S T IG + +A+Y+
Sbjct: 570 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 625
Query: 622 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 679
+D F + Y++++ K+ T +DL P Y S+ + E N+E+ + + I ++
Sbjct: 626 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 685
Query: 680 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV---APLEW 736
G ++LKE G+ I +T EN++E++ L +D+ + VE+Q KAF GF+ V +PL++
Sbjct: 686 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 745
Query: 737 LRYFDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLL 795
L F +E+EL++CG + +D +++T Y YT++S I+ FW++V +E++ L
Sbjct: 746 L--FRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFL 803
Query: 796 QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLR 854
QF TGT R PVGG +L K I K G +T LP SHTCFN L LP Y S E+L+
Sbjct: 804 QFTTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLK 856
Query: 855 EKLLYAIEETEGFG 868
E+LL AI +GFG
Sbjct: 857 ERLLKAITYAKGFG 870
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 213 bits (541), Expect = 8e-55
Identities = 128/374 (34%), Positives = 211/374 (56%), Gaps = 23/374 (6%)
Query: 505 LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 561
L L ++++ V R + +D+ + I P DL+++LY+ GE+G+D GG+++
Sbjct: 490 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 549
Query: 562 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 621
E+F L+ E+ NP +F Y ++ NP+S T IG + +A+Y+
Sbjct: 550 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 605
Query: 622 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 679
+D F + Y++++ K+ T +DL P Y S+ + E N+E+ + + I ++
Sbjct: 606 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 665
Query: 680 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV---APLEW 736
G ++LKE G+ I +T EN++E++ L +D+ + VE+Q KAF GF+ V +PL++
Sbjct: 666 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 725
Query: 737 LRYFDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLL 795
L F +E+EL++CG + +D +++T Y YT++S I+ FW++V +E++ L
Sbjct: 726 L--FRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFL 783
Query: 796 QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLR 854
QF TGT R PVGG +L K I K G +T LP SHTCFN L LP Y S E+L+
Sbjct: 784 QFTTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLK 836
Query: 855 EKLLYAIEETEGFG 868
E+LL AI +GFG
Sbjct: 837 ERLLKAITYAKGFG 850
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 213 bits (541), Expect = 8e-55
Identities = 128/374 (34%), Positives = 211/374 (56%), Gaps = 23/374 (6%)
Query: 505 LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 561
L L ++++ V R + +D+ + I P DL+++LY+ GE+G+D GG+++
Sbjct: 513 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 572
Query: 562 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 621
E+F L+ E+ NP +F Y ++ NP+S T IG + +A+Y+
Sbjct: 573 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 628
Query: 622 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 679
+D F + Y++++ K+ T +DL P Y S+ + E N+E+ + + I ++
Sbjct: 629 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 688
Query: 680 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV---APLEW 736
G ++LKE G+ I +T EN++E++ L +D+ + VE+Q KAF GF+ V +PL++
Sbjct: 689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 748
Query: 737 LRYFDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLL 795
L F +E+EL++CG + +D +++T Y YT++S I+ FW++V +E++ L
Sbjct: 749 L--FRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFL 806
Query: 796 QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLR 854
QF TGT R PVGG +L K I K G +T LP SHTCFN L LP Y S E+L+
Sbjct: 807 QFTTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLK 859
Query: 855 EKLLYAIEETEGFG 868
E+LL AI +GFG
Sbjct: 860 ERLLKAITYAKGFG 873
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 203 bits (517), Expect = 5e-52
Identities = 128/373 (34%), Positives = 199/373 (53%), Gaps = 30/373 (8%)
Query: 515 VKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNP 574
+ + V R L DS ++ K DL+++L + GE GLD GG+ +EWF LL ++ +P
Sbjct: 417 LNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHP 475
Query: 575 MYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRM 634
Y +F Y K+++C SS D+ + FR +G + +A+Y+ +D F YK++
Sbjct: 476 DYGMFTYH-KDSHCHWF---SSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Query: 635 LNK--------------RPTLKDLESIDPEFYNSIVWI--KENNLEECGLELYFIQDMEI 678
L+ T+ DL I PE + + + E N+EE + + E
Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
Query: 679 LGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLR 738
G + ++ LK GG+ I VT +N++EY+ L TD+ + + +Q AF GF+ V L
Sbjct: 592 -GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALM 650
Query: 739 YFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 798
+E+E+++CG ++DM Q+ST Y Y K I++FW VV + + +LL F
Sbjct: 651 LLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
Query: 799 TGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREKL 857
TG+ R+PVGG A+L F I K T LP +HTCFN+L LPPYKS + L++KL
Sbjct: 711 TGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
Query: 858 LYAIEETEGFGQE 870
+ I +EGFG E
Sbjct: 764 IIGISNSEGFGLE 776
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 198 bits (503), Expect = 2e-50
Identities = 136/379 (35%), Positives = 189/379 (49%), Gaps = 28/379 (7%)
Query: 507 HSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFL 566
H S V + VSR L E S + N D + ++ + EE LD+GG REWF L
Sbjct: 454 HMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFEL 513
Query: 567 LSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTY--FRFIGRFIAMALYHG----- 619
+ + + LF NN L ++P + P HL + F GR + LY
Sbjct: 514 ICKALFDTTNQLFTRFSDNNQAL-VHPNPN-RPAHLRLKMYEFAGRLVGKCLYESSLGGA 571
Query: 620 --KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNS-IVWIKENNLEECGLELYFIQDM 676
+ + FT F +++ R K E+ DPEFY S + +I N++ E +EL F ++
Sbjct: 572 YKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSE--MELVFAEEK 629
Query: 677 EI----LGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVA 732
L KV EL GG VT NK Y+ LL +R V+E+ + FL G NE+
Sbjct: 630 YNKSGQLDKVV--ELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELV 687
Query: 733 PLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIY--RHYTKNSKQIQWFWQVVKEMDNEK 790
P L FDE ELEL++CG +I +SD++ + + K ++WFW VV + E+
Sbjct: 688 PENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEE 747
Query: 791 RIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSY 850
RLLQF TG+ +LP GGFA L S F I + LP +HTCFN+L LP Y SY
Sbjct: 748 LARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHTCFNQLCLPTYDSY 802
Query: 851 EQLREKLLYAIEE-TEGFG 868
E++ L AI E EGFG
Sbjct: 803 EEVHRMLQLAISEGCEGFG 821
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 179 bits (454), Expect = 1e-44
Identities = 114/354 (32%), Positives = 184/354 (51%), Gaps = 17/354 (4%)
Query: 519 VSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 578
V R+ + D+ + + K D ++ L +I GE+ +D GG+ +E+F L+ E+L+P Y +
Sbjct: 705 VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 764
Query: 579 FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKR 638
F Y +++ + + + + D F IG +A+Y+ +D F L YK++L K+
Sbjct: 765 FRYY-EDSRLIWFSDKTFEDSD---LFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 820
Query: 639 PTLKDLESIDPEFYNSIVWI---KENNLEECGLELYFIQDMEILGKVTTHELKEGGESIR 695
P+L DL+ + P+ S+ + E+++EE L F +E G EL G
Sbjct: 821 PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFC-LNFTITVENFGATEVKELVLNGADTA 879
Query: 696 VTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEI 755
V ++N++E++ D+ F + V AF GF++V + L F EL+ M+ G
Sbjct: 880 VNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNY 939
Query: 756 DMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIG 814
D + +K+T Y+ Y I+ FW+V E+ EK+ + L F+TG+ R+P+ G L
Sbjct: 940 DWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-- 997
Query: 815 SNGPQKFCIDKVGK-ETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867
K I G E +LP SHTCFN LDLP Y E LR KL+ AI+ EGF
Sbjct: 998 -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 179 bits (454), Expect = 1e-44
Identities = 114/354 (32%), Positives = 184/354 (51%), Gaps = 17/354 (4%)
Query: 519 VSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 578
V R+ + D+ + + K D ++ L +I GE+ +D GG+ +E+F L+ E+L+P Y +
Sbjct: 713 VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 772
Query: 579 FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKR 638
F Y +++ + + + + D F IG +A+Y+ +D F L YK++L K+
Sbjct: 773 FRYY-EDSRLIWFSDKTFEDSD---LFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 828
Query: 639 PTLKDLESIDPEFYNSIVWI---KENNLEECGLELYFIQDMEILGKVTTHELKEGGESIR 695
P+L DL+ + P+ S+ + E+++EE L F +E G EL G
Sbjct: 829 PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFC-LNFTITVENFGATEVKELVLNGADTA 887
Query: 696 VTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEI 755
V ++N++E++ D+ F + V AF GF++V + L F EL+ M+ G
Sbjct: 888 VNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNY 947
Query: 756 DMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIG 814
D + +K+T Y+ Y I+ FW+V E+ EK+ + L F+TG+ R+P+ G L
Sbjct: 948 DWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-- 1005
Query: 815 SNGPQKFCIDKVGK-ETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867
K I G E +LP SHTCFN LDLP Y E LR KL+ AI+ EGF
Sbjct: 1006 -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1054
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,080,197
Number of Sequences: 37866
Number of extensions: 1996634
Number of successful extensions: 12366
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 158
Number of HSP's successfully gapped in prelim test: 510
Number of HSP's that attempted gapping in prelim test: 8865
Number of HSP's gapped (non-prelim): 2724
length of query: 870
length of database: 18,247,518
effective HSP length: 111
effective length of query: 759
effective length of database: 14,044,392
effective search space: 10659693528
effective search space used: 10659693528
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.