Search of human proteins with 32455239

Search of human proteins with 32455239

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo
sapiens]
         (292 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]     572   e-163
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      572   e-163
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho...   220   1e-57
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho...   194   1e-49
gi|38424079 short-chain dehydrogenase/reductase 10 isoform c [Ho...   140   1e-33
gi|38424075 short-chain dehydrogenase/reductase 10 isoform a [Ho...   139   2e-33
gi|38424083 short-chain dehydrogenase/reductase 10 isoform d [Ho...   127   2e-29
gi|38424081 short-chain dehydrogenase/reductase 10 isoform f [Ho...   100   2e-21
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    96   4e-20
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         92   5e-19
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    86   3e-17
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    84   1e-16
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    80   2e-15
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    80   2e-15
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    76   4e-14
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    75   7e-14
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    75   9e-14
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    74   1e-13
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]    74   2e-13
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           70   2e-12
gi|223646115 short chain dehydrogenase/reductase family 16C, mem...    67   2e-11
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ...    66   4e-11
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    66   4e-11
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          65   5e-11
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    65   7e-11
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ...    63   3e-10
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo...    63   3e-10
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ...    63   3e-10
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   60   2e-09
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi...    60   3e-09

>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score =  572 bits (1473), Expect = e-163
 Identities = 292/292 (100%), Positives = 292/292 (100%)

Query: 1   MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH 60
           MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
Sbjct: 1   MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH 60

Query: 61  VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH 120
           VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
Sbjct: 61  VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH 120

Query: 121 ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV 180
           ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
Sbjct: 121 ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV 180

Query: 181 AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE 240
           AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
Sbjct: 181 AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE 240

Query: 241 CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK 292
           CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Sbjct: 241 CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK 292


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score =  572 bits (1473), Expect = e-163
 Identities = 292/292 (100%), Positives = 292/292 (100%)

Query: 1   MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH 60
           MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
Sbjct: 1   MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH 60

Query: 61  VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH 120
           VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
Sbjct: 61  VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH 120

Query: 121 ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV 180
           ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
Sbjct: 121 ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV 180

Query: 181 AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE 240
           AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
Sbjct: 181 AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE 240

Query: 241 CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK 292
           CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Sbjct: 241 CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK 292


>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
           sapiens]
          Length = 286

 Score =  220 bits (561), Expect = 1e-57
 Identities = 124/256 (48%), Positives = 162/256 (63%), Gaps = 4/256 (1%)

Query: 4   MKKYLLPILG-LFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVV 62
           MK  LL  LG LF AYY+   ++ F P  LQG +V++TGA+ G+G E+AYH A++G+H+V
Sbjct: 1   MKVLLLTGLGALFFAYYW---DDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLV 57

Query: 63  VTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHIT 122
           +TA ++  LQKVV +C +LGA    YIA  M      E  V  A   +GGLD L+LNHI 
Sbjct: 58  LTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIG 117

Query: 123 NTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAA 182
                         R  M+VNF+SYV LT  ALP L  S GS+VVVSSL G+V       
Sbjct: 118 GAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTP 177

Query: 183 YSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA 242
           YSA+KFALDGFF S+R+E  V  VNV+IT+CVLGL D  +A +AV G+  ++AAP  + A
Sbjct: 178 YSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAA 237

Query: 243 LEIIKGGALRQEEVYY 258
           L +I+GGA R   V+Y
Sbjct: 238 LAVIRGGATRAAGVFY 253


>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
           sapiens]
          Length = 315

 Score =  194 bits (492), Expect = 1e-49
 Identities = 111/225 (49%), Positives = 142/225 (63%), Gaps = 4/225 (1%)

Query: 4   MKKYLLPILG-LFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVV 62
           MK  LL  LG LF AYY+   ++ F P  LQG +V++TGA+ G+G E+AYH A++G+H+V
Sbjct: 1   MKVLLLTGLGALFFAYYW---DDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLV 57

Query: 63  VTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHIT 122
           +TA ++  LQKVV +C +LGA    YIA  M      E  V  A   +GGLD L+LNHI 
Sbjct: 58  LTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIG 117

Query: 123 NTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAA 182
                         R  M+VNF+SYV LT  ALP L  S GS+VVVSSL G+V       
Sbjct: 118 GAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTP 177

Query: 183 YSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAV 227
           YSA+KFALDGFF S+R+E  V  VNV+IT+CVLGL D  +A +AV
Sbjct: 178 YSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAV 222


>gi|38424079 short-chain dehydrogenase/reductase 10 isoform c [Homo
           sapiens]
          Length = 199

 Score =  140 bits (354), Expect = 1e-33
 Identities = 79/159 (49%), Positives = 99/159 (62%)

Query: 100 EQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLK 159
           E  V  A   +GGLD L+LNHI               R  M+VNF+SYV LT  ALP L 
Sbjct: 8   ESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLT 67

Query: 160 QSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLID 219
            S GS+VVVSSL G+V       YSA+KFALDGFF S+R+E  V  VNV+IT+CVLGL D
Sbjct: 68  DSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRD 127

Query: 220 TETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYY 258
             +A +AV G+  ++AAP  + AL +I+GGA R   V+Y
Sbjct: 128 RASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFY 166


>gi|38424075 short-chain dehydrogenase/reductase 10 isoform a [Homo
           sapiens]
          Length = 205

 Score =  139 bits (351), Expect = 2e-33
 Identities = 76/148 (51%), Positives = 95/148 (64%)

Query: 111 GGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSS 170
           GGLD L+LNHI               R  M+VNF+SYV LT  ALP L  S GS+VVVSS
Sbjct: 25  GGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSS 84

Query: 171 LAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGI 230
           L G+V       YSA+KFALDGFF S+R+E  V  VNV+IT+CVLGL D  +A +AV G+
Sbjct: 85  LLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGV 144

Query: 231 VHMQAAPKEECALEIIKGGALRQEEVYY 258
             ++AAP  + AL +I+GGA R   V+Y
Sbjct: 145 TRVKAAPGPKAALAVIRGGATRAAGVFY 172


>gi|38424083 short-chain dehydrogenase/reductase 10 isoform d [Homo
           sapiens]
          Length = 152

 Score =  127 bits (318), Expect = 2e-29
 Identities = 66/119 (55%), Positives = 84/119 (70%)

Query: 140 MEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRK 199
           M+VNF+SYV LT  ALP L  S GS+VVVSSL G+V       YSA+KFALDGFF S+R+
Sbjct: 1   MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRR 60

Query: 200 EYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYY 258
           E  V  VNV+IT+CVLGL D  +A +AV G+  ++AAP  + AL +I+GGA R   V+Y
Sbjct: 61  ELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFY 119


>gi|38424081 short-chain dehydrogenase/reductase 10 isoform f [Homo
           sapiens]
          Length = 181

 Score =  100 bits (249), Expect = 2e-21
 Identities = 53/88 (60%), Positives = 64/88 (72%)

Query: 140 MEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRK 199
           M+VNF+SYV LT  ALP L  S GS+VVVSSL G+V       YSA+KFALDGFF S+R+
Sbjct: 1   MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRR 60

Query: 200 EYSVSRVNVSITLCVLGLIDTETAMKAV 227
           E  V  VNV+IT+CVLGL D  +A +AV
Sbjct: 61  ELDVQDVNVAITMCVLGLRDRASAAEAV 88


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 95.9 bits (237), Expect = 4e-20
 Identities = 65/178 (36%), Positives = 94/178 (52%), Gaps = 5/178 (2%)

Query: 28  RPEM-LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASA 86
           RPE  L    V VTGAS GIG E+AY L+K+G  +V++AR    L++V   CLE G    
Sbjct: 43  RPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKE 102

Query: 87  HYIAGTMEDMTFAEQFVAQAGKLM---GGLDMLILNHITNTSLNLFHDDIHHVRKSMEVN 143
             I     D+T      A    ++   G +D+L+ N   +         +   RK +E+N
Sbjct: 103 KDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELN 162

Query: 144 FLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKE 200
           +L  V LT   LP M+++  G IV V+S+ G ++ P+   Y ASK AL GFF+ +R E
Sbjct: 163 YLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTE 220


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 92.0 bits (227), Expect = 5e-19
 Identities = 78/268 (29%), Positives = 129/268 (48%), Gaps = 17/268 (6%)

Query: 6   KYLLPILGLFMAYYYYSANEEF-------RPEMLQGKKVIVTGASKGIGREMAYHLAKMG 58
           K+LL IL L +      + E F       R + + G+ V++TGA  GIGR  AY  AK+ 
Sbjct: 2   KFLLDIL-LLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60

Query: 59  AHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKL---MGGLDM 115
           + +V+   +K  L++  + C  LGA    ++     D +  E   + A K+   +G + +
Sbjct: 61  SKLVLWDINKHGLEETAAKCKGLGAKVHTFVV----DCSNREDIYSSAKKVKAEIGDVSI 116

Query: 116 LILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGK 174
           L+ N     + +LF      + K+ EVN L++   T A LP M K ++G IV V+S AG 
Sbjct: 117 LVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGH 176

Query: 175 VAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQ 234
           V+ P + AY +SKFA  GF  ++  E +  ++    T C+         +K  S  +   
Sbjct: 177 VSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPT 236

Query: 235 AAPKEECALEIIKGGALRQEEVYYDSSL 262
             P EE    ++ G    Q+ ++  SS+
Sbjct: 237 LEP-EEVVNRLMHGILTEQKMIFIPSSI 263


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 56/203 (27%), Positives = 103/203 (50%), Gaps = 8/203 (3%)

Query: 32  LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVV-----SHCLELGAASA 86
           L+   V++TGA+ G+G+E A      GA +V+  R+   L++++     SH  ++     
Sbjct: 50  LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109

Query: 87  HYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLS 146
           + +   + D        A+  +  G +D+L+ N   +    +    +   ++ ME N+  
Sbjct: 110 YLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFG 169

Query: 147 YVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSR 205
            V LT A LP M+K+  G IV +SS+ GK++ P  +AY+ASK A   FF  +R E  + +
Sbjct: 170 PVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAE--MEQ 227

Query: 206 VNVSITLCVLGLIDTETAMKAVS 228
             + +T+   G I T  ++ A++
Sbjct: 228 YEIEVTVISPGYIHTNLSVNAIT 250


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 84.0 bits (206), Expect = 1e-16
 Identities = 64/197 (32%), Positives = 103/197 (52%), Gaps = 9/197 (4%)

Query: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87
           R + L  K  +VT ++ GIG  +A  LA+ GAHVVV++R ++ + + V+     G +   
Sbjct: 26  RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85

Query: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHV-RKSMEVNF 144
            +   G  ED    E+ VA A KL GG+D+L+ N   N       D    V  K++++N 
Sbjct: 86  TVCHVGKAED---RERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142

Query: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
            +  ++T A +P M K+  GS+V+VSS+A     P  + Y+ SK AL G   ++  E  +
Sbjct: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIE--L 200

Query: 204 SRVNVSITLCVLGLIDT 220
           +  N+ +     GLI T
Sbjct: 201 APRNIRVNCLAPGLIKT 217


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 56/198 (28%), Positives = 101/198 (51%), Gaps = 12/198 (6%)

Query: 11  ILGLFMAYYYYSANEEF----RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTAR 66
           +L + + Y Y  +  +F    R + + G+ V++TGA  GIGR+  Y  AK  + +V+   
Sbjct: 9   LLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDI 68

Query: 67  SKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQF---VAQAGKLMGGLDMLILNHITN 123
           +K  +++  + C +LG  +  Y+     D +  E+    + Q  K +G + +++ N  T 
Sbjct: 69  NKRGVEETAAECRKLGVTAHAYVV----DCSNREEIYRSLNQVKKEVGDVTIVVNNAGTV 124

Query: 124 TSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAA 182
              +L       + K+ EVN L +  +T A LP M+++++G IV V+S+ G    P +  
Sbjct: 125 YPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIP 184

Query: 183 YSASKFALDGFFSSIRKE 200
           Y +SKFA  GF   +  E
Sbjct: 185 YCSSKFAAVGFHRGLTSE 202


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 59/186 (31%), Positives = 98/186 (52%), Gaps = 7/186 (3%)

Query: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87
           R + L  K  +VT ++ GIG  +A  LA+  AHVVV++R ++ + + V+     G +   
Sbjct: 26  RRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85

Query: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHV-RKSMEVNF 144
            +   G  ED    E+ VA A KL GG+D+L+ N   N       D    V  K++++N 
Sbjct: 86  TVCHVGKAED---RERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINV 142

Query: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
            +  ++T A +P M K+  GS+V+VSS+A     P  + Y+ SK AL G  +++  E + 
Sbjct: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAP 202

Query: 204 SRVNVS 209
             + V+
Sbjct: 203 RNIRVN 208


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 59/191 (30%), Positives = 94/191 (49%), Gaps = 9/191 (4%)

Query: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETL----QKVVSHCLELGA 83
           +P  L G  V+VTG S GIG+ +A    K GA + + AR+++ L    +++  H +    
Sbjct: 26  KPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQ 85

Query: 84  ASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHD-DIHHVRKSMEV 142
                     +D    E  + QA + +G +DML+ N         F D ++    + M +
Sbjct: 86  VVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLV-NCAGMAVSGKFEDLEVSTFERLMSI 144

Query: 143 NFLSYVVLTVAALPMLKQSN-GSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEY 201
           N+L  V  + A +  +K+   G IV VSS AG++      AYSASKFA+ G   +++ E 
Sbjct: 145 NYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQME- 203

Query: 202 SVSRVNVSITL 212
            V   NV IT+
Sbjct: 204 -VKPYNVYITV 213


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 59/222 (26%), Positives = 101/222 (45%), Gaps = 11/222 (4%)

Query: 1   MAFMKKYLLPILGLFMA---YYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKM 57
           M  M   +LP+L L ++   + Y   +  +    +Q K V++T A  G+G+E A      
Sbjct: 1   MGVMAMLMLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTG 60

Query: 58  GAHVVVTARSKETLQKVVSHCLELGAASAHY----IAGTMEDMTFAEQFVAQAGKLMGGL 113
           GA +V+  ++ E L+ +    + +   S  +    +   + D++       +     G +
Sbjct: 61  GARLVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCV 120

Query: 114 DMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLA 172
           D+LI N             +   +K M+ N+   + LT A LP M+ +  G IV+V+++ 
Sbjct: 121 DILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQ 180

Query: 173 GKVAYPMVAAYSASKFALDGFFSSIR---KEYSVSRVNVSIT 211
           GK   P    Y+ASK A  GFF  +R   +EY V    VS T
Sbjct: 181 GKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPT 222


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 59/210 (28%), Positives = 105/210 (50%), Gaps = 10/210 (4%)

Query: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87
           R  +L  +  +VTG++ GIG  +A  LA+ GAHVV+++R ++ + + ++     G + A 
Sbjct: 30  RKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAG 89

Query: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHV-RKSMEVNF 144
            +   G  ED    EQ VA+A +  GG+D L+ +   N  +         +  K + VN 
Sbjct: 90  IVCHVGKAED---REQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNV 146

Query: 145 LSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVS 204
            S  +L    LP ++   G++++VSS+A       +  Y+ SK AL G   ++  E +  
Sbjct: 147 KSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPK 206

Query: 205 RVNVSITLCVL-GLIDTETAMKAVSGIVHM 233
            + V+   CV+ G+I T+ +     G + M
Sbjct: 207 DIRVN---CVVPGIIKTDFSKVVRIGFMGM 233


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 57/198 (28%), Positives = 101/198 (51%), Gaps = 10/198 (5%)

Query: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87
           R  +L  +  +VTG++ GIG  +A  LA+ GAHVV+++R ++ + + ++     G + A 
Sbjct: 30  RKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAG 89

Query: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHV-RKSMEVNF 144
            +   G  ED    EQ VA+A +  GG+D L+ +   N  +         +  K + VN 
Sbjct: 90  IVCHVGKAED---REQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNV 146

Query: 145 LSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVS 204
            S  +L    LP ++   G++++VSS+A       +  Y+ SK AL G   ++  E +  
Sbjct: 147 KSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPK 206

Query: 205 RVNVSITLCVL-GLIDTE 221
            + V+   CV+ G+I T+
Sbjct: 207 DIRVN---CVVPGIIKTD 221


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 57/189 (30%), Positives = 97/189 (51%), Gaps = 17/189 (8%)

Query: 34  GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93
           G+  +VTG++ GIG+  A  LAK G  VV+ +RSK+ L +V S   E        IA   
Sbjct: 50  GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIA--- 106

Query: 94  EDMTFAEQFVAQAGKL-MGGLDMLILNHITNTSLNLFHDDI--------HHVRKSMEVNF 144
             + FA + +    K  + GL++ IL  + N  ++  + +         + ++K + +N 
Sbjct: 107 --VDFASEDIYDKIKTGLAGLEIGIL--VNNVGMSYEYPEYFLDVPDLDNVIKKMININI 162

Query: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
           LS   +T   LP M+++S G+I+ +SS +G +  P++  YSA+K  +D F   + +EY  
Sbjct: 163 LSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS 222

Query: 204 SRVNVSITL 212
             V V   L
Sbjct: 223 KGVFVQSVL 231


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 63/226 (27%), Positives = 102/226 (45%), Gaps = 3/226 (1%)

Query: 34  GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93
           G+ V++TGA  G+GR +A   A++G+ +V+   +KE  ++      E GA   H      
Sbjct: 40  GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDC 99

Query: 94  EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153
                  +   Q  K +G + +LI N    T           + KS +VNF +++    A
Sbjct: 100 SQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKA 159

Query: 154 ALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSR-VNVSIT 211
            LP M+   +G +V +SS AG      +A Y ASKFA  GF  S+  E  V +   +  T
Sbjct: 160 FLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTT 219

Query: 212 LCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVY 257
           +     I T       +G   +    + + A+E I   A+ QE++Y
Sbjct: 220 IVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIV-EAILQEKMY 264


>gi|223646115 short chain dehydrogenase/reductase family 16C, member
           6 [Homo sapiens]
          Length = 323

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 68/259 (26%), Positives = 114/259 (44%), Gaps = 13/259 (5%)

Query: 11  ILGLFMAYYYYSANEEFRPEM---LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARS 67
           +LG F  Y+  S   +  P+    + G+ V+ TGA  G+GR++A + A+ GA +V+   +
Sbjct: 10  LLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVN 69

Query: 68  KETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLN 127
           +E   +      E G            +     +   Q  K  G + +L+ N    T   
Sbjct: 70  QEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKP 129

Query: 128 LFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVA-------YPM 179
                 H V KS  VN +++     A LP ++K ++G +V +SS+AG V        Y +
Sbjct: 130 FLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFV 189

Query: 180 VAAYSASKFALDGFFSSIRKEYS-VSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPK 238
              YSASKFA  GF  S+  E + + +  V  T+     I+T       S    +    +
Sbjct: 190 SPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILE 249

Query: 239 EECALEIIKGGALRQEEVY 257
           +E   + I   A+ +E+VY
Sbjct: 250 QEYVAKKIL-NAILEEQVY 267


>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
           [Homo sapiens]
          Length = 281

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 59/201 (29%), Positives = 102/201 (50%), Gaps = 14/201 (6%)

Query: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87
           R + L  K  +VT ++  IG  +A  LA+ GAHVVV+ R ++ + + V+     G +   
Sbjct: 26  RRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTG 85

Query: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVR-----KSM 140
            +   G M+D    E+ VA A KL G +D+L L+ ITN+   LF   +         +++
Sbjct: 86  TVCHVGKMKDW---ERLVATAMKLHGVIDILSLS-ITNSKRGLFWFTLLQTAEEAWDRNL 141

Query: 141 EVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRK 199
           ++N  +  ++  A +P M K+  GS+  ++S+A     P  + Y+ SK AL G   ++  
Sbjct: 142 DINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAI 201

Query: 200 EYSVSRVNVSITLCVLGLIDT 220
           E  ++  N+ +     GLI T
Sbjct: 202 E--LAPRNIRVNCLAPGLIKT 220


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 59/211 (27%), Positives = 99/211 (46%), Gaps = 18/211 (8%)

Query: 7   YLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVV---V 63
           YL   +GL+   ++Y   +      LQ K V +TG   G G  +A  L   G  V+   +
Sbjct: 4   YLAAFVGLYYLLHWYRERQVV--SHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACL 61

Query: 64  TARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQ--AGKLMGGL--DMLILN 119
           T +  E L+   S  LE            ME +  A Q+V +    + + GL  +  IL 
Sbjct: 62  TEKGAEQLRGQTSDRLETVTLDVT----KMESIAAATQWVKEHVGDRGLWGLVNNAGILT 117

Query: 120 HITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPM 179
            IT        D ++     ++VN +  + +T++ LP+++++ G IV VSS+ G+VA+  
Sbjct: 118 PITLCEWLNTEDSMN----MLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAF-F 172

Query: 180 VAAYSASKFALDGFFSSIRKEYSVSRVNVSI 210
           V  Y  SK+ ++ F   +R+E     V +SI
Sbjct: 173 VGGYCVSKYGVEAFSDILRREIQHFGVKISI 203


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 61/203 (30%), Positives = 92/203 (45%), Gaps = 15/203 (7%)

Query: 35  KKVIVTGASKGIGREMAYHLA---KMGAHVVVTARS---KETLQKVVSHCLELGAASAHY 88
           + V+++G S GIG E+A  LA   K    VV T R    KETL+         G A    
Sbjct: 6   RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAA------GEALGQT 59

Query: 89  IAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYV 148
           +     D+   E        + G +D+L+ N        L    +  ++   + NF   V
Sbjct: 60  LTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAV 119

Query: 149 VLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVN 207
            L  A LP M ++  G IVV+SS+ G         Y+ASKFAL+GFF S+     + + N
Sbjct: 120 RLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESL--AIQLLQFN 177

Query: 208 VSITLCVLGLIDTETAMKAVSGI 230
           + I+L   G + TE   K ++ +
Sbjct: 178 IFISLVEPGPVVTEFEGKLLAQV 200


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 8/177 (4%)

Query: 37  VIVTGASKGIGREMAYHLAKMGAHVV---VTARSKETLQKVVSHCLELGAASAHYIAGTM 93
           V +TG   G GR +A  L + G  V+   +T    E LQ+V S  L              
Sbjct: 31  VFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQ 90

Query: 94  EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153
           +   + E  V +AG L G ++   +  I   +  L  DD   V   + VN +  + +T+A
Sbjct: 91  QAAKWVEMHVKEAG-LFGLVNNAGVAGIIGPTPWLTRDDFQRV---LNVNTMGPIGVTLA 146

Query: 154 ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSI 210
            LP+L+Q+ G ++ ++S+ G++A      Y  SKF L+ F  S+R++ +   + VSI
Sbjct: 147 LLPLLQQARGRVINITSVLGRLA-ANGGGYCVSKFGLEAFSDSLRRDVAHFGIRVSI 202


>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
           sapiens]
          Length = 302

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 46/168 (27%), Positives = 78/168 (46%), Gaps = 3/168 (1%)

Query: 32  LQGKKVIVTGASKGIGREMAYHLAKMGAH-VVVTARSKETLQKVVSHCLELGAASAHYIA 90
           L  + V++TG  +GIGR++A   A+ GA  +V+  R+++ L++      ++G    HY  
Sbjct: 36  LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMG-TECHYFI 94

Query: 91  GTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVL 150
             + +     Q      + +G + +L+ N       +L   D   + KS  +N L     
Sbjct: 95  CDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWT 154

Query: 151 TVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSI 197
           T A LP ML+  NG IV ++S+    A P    Y  SK +   F  S+
Sbjct: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESL 202


>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
           sapiens]
          Length = 313

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 57/198 (28%), Positives = 83/198 (41%), Gaps = 11/198 (5%)

Query: 32  LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAG 91
           + G+  +VTGAS+GIGR +A  L K GA V +T R  +TL+ V      LG      +  
Sbjct: 5   MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCD 64

Query: 92  TMEDMTFAEQFVAQAGKLMGGLDMLILNHI--TNTSLNLFHDDIHHVRKSM--EVNFLS- 146
           + ++      F     +  G LD+L+ N      T LN  +        SM  ++N +  
Sbjct: 65  SSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGL 124

Query: 147 ---YVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
              Y      A  M+    G IVV+SS  G + Y     Y   K A D   +    E  +
Sbjct: 125 RGHYFCSVYGARLMVPAGQGLIVVISS-PGSLQYMFNVPYGVGKAACDKLAADCAHE--L 181

Query: 204 SRVNVSITLCVLGLIDTE 221
            R  VS      G++ TE
Sbjct: 182 RRHGVSCVSLWPGIVQTE 199


>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
           sapiens]
          Length = 313

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 57/198 (28%), Positives = 83/198 (41%), Gaps = 11/198 (5%)

Query: 32  LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAG 91
           + G+  +VTGAS+GIGR +A  L K GA V +T R  +TL+ V      LG      +  
Sbjct: 5   MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCD 64

Query: 92  TMEDMTFAEQFVAQAGKLMGGLDMLILNHI--TNTSLNLFHDDIHHVRKSM--EVNFLS- 146
           + ++      F     +  G LD+L+ N      T LN  +        SM  ++N +  
Sbjct: 65  SSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGL 124

Query: 147 ---YVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
              Y      A  M+    G IVV+SS  G + Y     Y   K A D   +    E  +
Sbjct: 125 RGHYFCSVYGARLMVPAGQGLIVVISS-PGSLQYMFNVPYGVGKAACDKLAADCAHE--L 181

Query: 204 SRVNVSITLCVLGLIDTE 221
            R  VS      G++ TE
Sbjct: 182 RRHGVSCVSLWPGIVQTE 199


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 52/207 (25%), Positives = 96/207 (46%), Gaps = 10/207 (4%)

Query: 7   YLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVV---V 63
           YL   +GL+   ++Y   +      L+ K V +TG   G G+ +A  L   G  V+   +
Sbjct: 4   YLAVFVGLYYLLHWYRERQVL--SHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACL 61

Query: 64  TARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITN 123
           T +  E L+   S  LE                 + ++ V   G L G ++   ++  T 
Sbjct: 62  TEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKG-LWGLVNNAGISLPTA 120

Query: 124 TSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAY 183
            +  L   D   +   ++VN L  + +T++ LP+++++ G +V VSS+ G+V+      Y
Sbjct: 121 PNELLTKQDFVTI---LDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSL-FGGGY 176

Query: 184 SASKFALDGFFSSIRKEYSVSRVNVSI 210
             SK+ ++ F  S+R+E S   V V++
Sbjct: 177 CISKYGVEAFSDSLRRELSYFGVKVAM 203


>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
           sapiens]
          Length = 405

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 59/199 (29%), Positives = 84/199 (42%), Gaps = 29/199 (14%)

Query: 28  RPEMLQ--GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAAS 85
           RP+ L    + V++TG   G G+E A  L  MG  V+ T      L+      +EL    
Sbjct: 74  RPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATV-----LELNSPGAIELRTCC 128

Query: 86  AHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSL-----NLFHDDI------- 133
           +  +     D+T       + G +   L+     H T+T L     N  H+++       
Sbjct: 129 SPRLRLLQMDLT-------KPGDISRVLEFTKA-HTTSTGLWGLVNNAGHNEVVADAELS 180

Query: 134 --HHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALD 191
                R  MEVNF   + LT   LP+L+ S G IV V S AG + YP + AY  SK A+ 
Sbjct: 181 PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA 240

Query: 192 GFFSSIRKEYSVSRVNVSI 210
               +   E     V VSI
Sbjct: 241 LLMDTFSCELLPWGVKVSI 259


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.134    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,860,886
Number of Sequences: 37866
Number of extensions: 323888
Number of successful extensions: 894
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 755
Number of HSP's gapped (non-prelim): 87
length of query: 292
length of database: 18,247,518
effective HSP length: 101
effective length of query: 191
effective length of database: 14,423,052
effective search space: 2754802932
effective search space used: 2754802932
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.