Search of human proteins with 11968059

Search of human proteins with 11968059

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
sapiens]
         (562 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...  1187   0.0  
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   511   e-145
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   389   e-108
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   372   e-103
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   370   e-102
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   370   e-102
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   303   3e-82
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   272   7e-73
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    248   8e-66
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   241   1e-63
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   239   4e-63
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   236   5e-62
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    233   3e-61
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   227   3e-59
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   225   7e-59
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   207   2e-53
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   207   3e-53
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                206   6e-53
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      201   1e-51
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      188   1e-47
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   188   1e-47
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    180   3e-45
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   135   8e-32
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   134   2e-31
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   113   5e-25
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]       92   1e-18
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    79   8e-15
gi|88853069 vitronectin precursor [Homo sapiens]                       59   1e-08
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]           50   5e-06
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]           50   7e-06

>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score = 1187 bits (3071), Expect = 0.0
 Identities = 562/562 (100%), Positives = 562/562 (100%)

Query: 1   MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRD 60
           MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRD
Sbjct: 1   MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRD 60

Query: 61  AIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTL 120
           AIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTL
Sbjct: 61  AIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTL 120

Query: 121 TWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQ 180
           TWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQ
Sbjct: 121 TWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQ 180

Query: 181 DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG 240
           DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG
Sbjct: 181 DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG 240

Query: 241 LGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQ 300
           LGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQ
Sbjct: 241 LGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQ 300

Query: 301 PPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFW 360
           PPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFW
Sbjct: 301 PPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFW 360

Query: 361 EGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVF 420
           EGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVF
Sbjct: 361 EGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVF 420

Query: 421 SWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKG 480
           SWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKG
Sbjct: 421 SWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKG 480

Query: 481 AHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAA 540
           AHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAA
Sbjct: 481 AHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAA 540

Query: 541 GRWPAPIPLLLLPLLVGGVASR 562
           GRWPAPIPLLLLPLLVGGVASR
Sbjct: 541 GRWPAPIPLLLLPLLVGGVASR 562


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  511 bits (1317), Expect = e-145
 Identities = 274/581 (47%), Positives = 347/581 (59%), Gaps = 34/581 (5%)

Query: 4   RLRLLALLLLLLAP----PARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLR 59
           RL L  LLLL L       A AP P A+D+SLGV+WL+R+GYLPP  P   QLQ+ E+L 
Sbjct: 20  RLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELS 79

Query: 60  DAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRT 119
            AI  MQ+F GL  TG +D  T+A M+ PRCSLPD+  +     RRRR A + + W KR 
Sbjct: 80  KAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQA--RRRRQAPAPTKWNKRN 137

Query: 120 LTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFH 179
           L+WRVR+FP+ S L  +TVR LM YAL  W   + L FHEV    G   DI IDF++A H
Sbjct: 138 LSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEV---AGSAADIQIDFSKADH 194

Query: 180 QDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHAL 239
            D YPFDG GGT+AHAFFPG H  +GDTHFDD+E WTF S D  G DLFAVAVHEFGHA+
Sbjct: 195 NDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAI 254

Query: 240 GLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYG-KAPQTPYDKPTRKPLAPP 298
           GL H +A +SIMRP+YQGPVGDP +Y L  +D+  + QLYG +   +P  +P   PL P 
Sbjct: 255 GLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPE 314

Query: 299 PQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHR 358
           P P    +  P   +P RC  +FDA+A IRGE FFFKG +FWRL     LVS +PA++HR
Sbjct: 315 P-PDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHR 373

Query: 359 FWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELGLPPGEEVD 417
           FW GLP  +  V A Y R  D +I+ F G ++WVF+D  +E G  RP+++  LPPG  +D
Sbjct: 374 FWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPG-GID 432

Query: 418 AVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYF 477
           A FSW  N +TY  + + YWRYD+     DPGYP    LW G P + DD    + G +YF
Sbjct: 433 AAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYF 492

Query: 478 FKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC------PAPSSGPRAPRPPKATPVS---- 527
           F+G  YW+     ++  P  PQ    +WL C       + ++G  A   P+A P      
Sbjct: 493 FRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAEGPRAPPGQHDQS 552

Query: 528 ------ETCDCQCELNQAAGRWPAPI----PLLLLPLLVGG 558
                 E C C    +   G  P P+     LLLLP L  G
Sbjct: 553 RSEDGYEVCSCTSGASSPPGA-PGPLVAATMLLLLPPLSPG 592


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  389 bits (999), Expect = e-108
 Identities = 231/565 (40%), Positives = 311/565 (55%), Gaps = 61/565 (10%)

Query: 4   RLRLLALLLLLLAPPARAPKPSAQDVSLGVD-WLTRYGYLPPPHPAQAQLQSPEKLRDAI 62
           R RLL LLL+LL         +A+D  +  + WL  YGYLP P    + ++S + L  A+
Sbjct: 26  RPRLLPLLLVLLG--CLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASAL 83

Query: 63  KVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGV---AGLVRRRRRYALSGSVWKKRT 119
             MQRF G+P TG +D  T   M++PRC +PD  GV   A L RRR+RYAL+G  W    
Sbjct: 84  AEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHH 143

Query: 120 LTWRVRSFPQSSQL--SQETVRVLMSYALMAWGMESGLTFHEVDSP-----QGQEPDILI 172
           LT+ ++++ +      S E VR     A   W   + L F EV        + +E DI++
Sbjct: 144 LTFSIQNYTEKLGWYHSMEAVR----RAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMV 199

Query: 173 DFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAV 232
            FA  FH DS PFDG GG LAHA+FPG   + GDTHFD +E WTF S D  G +LF VAV
Sbjct: 200 LFASGFHGDSSPFDGTGGFLAHAYFPGPG-LGGDTHFDADEPWTFSSTDLHGNNLFLVAV 258

Query: 233 HEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYG------------ 280
           HE GHALGL HSS PN+IM PFYQ    D D ++L +DD  G+QQLYG            
Sbjct: 259 HELGHALGLEHSSNPNAIMAPFYQWK--DVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPL 316

Query: 281 -----KAPQTPYDKPTRKPLAPP----------PQPPASP--THSPSFPIPDRCEGNFDA 323
                + P  P  +P R P  PP          P PP  P  T  P    P+ C+G+FD 
Sbjct: 317 PTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDT 376

Query: 324 IANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRIL 383
           +A +RGE F FKG WFWR++   +++   P  +  FW GLP     + AAY R +DGR +
Sbjct: 377 VAMLRGEMFVFKGRWFWRVR-HNRVLDNYPMPIGHFWRGLPGD---ISAAYER-QDGRFV 431

Query: 384 LFSGPQFWVFQDRQLEGG-ARPLTELGLP-PGEEVDAVFSWPQNGKTYLVRGRQYWRYDE 441
            F G ++W+F++  LE G  +PLT  GL  P + +D    W   G T+  +  +YWR++E
Sbjct: 432 FFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNE 491

Query: 442 AAARPDPGYPRDLSLWEGAPPSPDDVTVSN-AGDTYFFKGAHYWRFPKNSIKTEPDAPQP 500
              R DPGYP+ +S+W+G P SP    +SN A  TYF+KG  YW+F    ++ EP  P+ 
Sbjct: 492 ETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKS 551

Query: 501 MGPNWLDCPA-PSSGPRAP---RPP 521
           +  +++ C      GPR P   RPP
Sbjct: 552 ILRDFMGCQEHVEPGPRWPDVARPP 576


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  372 bits (954), Expect = e-103
 Identities = 202/502 (40%), Positives = 287/502 (57%), Gaps = 38/502 (7%)

Query: 32  GVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCS 91
           G +WL  YGYL P     + L S + L+ A+  MQ+F G+P TG +D  T+  M+KPRC 
Sbjct: 81  GQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCG 140

Query: 92  LPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGM 151
           +PD   ++   RR +RYAL+G  W+++ +T+ + ++  + ++ +   R  +  A   W  
Sbjct: 141 VPDHPHLSRR-RRNKRYALTGQKWRQKHITYSIHNY--TPKVGELDTRKAIRQAFDVWQK 197

Query: 152 ESGLTF-----HEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGD 206
            + LTF     HE+ S + +E DI+I FA  FH DS PFDG GG LAHA+FPG   I GD
Sbjct: 198 VTPLTFEEVPYHEIKSDR-KEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPG-IGGD 255

Query: 207 THFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYR 266
           THFD +E WT G+ + +G DLF VAVHE GHALGL HSS P++IM PFYQ    +   ++
Sbjct: 256 THFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQ--YMETHNFK 313

Query: 267 LSQDDRDGLQQLYGKAPQTPYDKPTRKPLAP-----------------PPQPPASPTHSP 309
           L QDD  G+Q++YG  P  P +     P  P                 PP+PP     S 
Sbjct: 314 LPQDDLQGIQKIYG-PPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPST 372

Query: 310 SFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRV 369
               P+ C+GNF+ +A  RGE F FK  WFWRL+ + ++    P ++ +FW+GLPA+   
Sbjct: 373 PGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLR-NNRVQEGYPMQIEQFWKGLPAR--- 428

Query: 370 VQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELG-LPPGEEVDAVFSWPQNGK 427
           + AAY R  DGR + F G ++WVF++  +E G    L ELG   P E +D    W   GK
Sbjct: 429 IDAAYER-ADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGK 487

Query: 428 TYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAG-DTYFFKGAHYWRF 486
           TY  +G +YWRY E     DPGYP+ +++W+G P +P    +S  G  TYF+KG  YW+F
Sbjct: 488 TYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKF 547

Query: 487 PKNSIKTEPDAPQPMGPNWLDC 508
               +  EP  P+ +  +W+ C
Sbjct: 548 DNQKLSVEPGYPRNILRDWMGC 569


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  370 bits (951), Expect = e-102
 Identities = 226/569 (39%), Positives = 310/569 (54%), Gaps = 45/569 (7%)

Query: 10  LLLLLLAPPARAPKPSAQDVSLGVD-WLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRF 68
           LL LL    A A   SAQ  S   + WL +YGYLPP        +SP+ L  AI  MQ+F
Sbjct: 12  LLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKF 71

Query: 69  AGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVR-RRRRYALSGSVWKKRTLTWRVRSF 127
            GL  TG+ D  T+  MR+PRC +PD  G       RR+RYA+ G  W+   +T+ ++++
Sbjct: 72  YGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNY 131

Query: 128 PQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSP---QGQEP--DILIDFARAFHQDS 182
             + ++ +      +  A   W   + L F EV      +G E   DI+I FA  FH DS
Sbjct: 132 --TPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDS 189

Query: 183 YPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLG 242
            PFDG GG LAHA+FPG + I GDTHFD  E WT  ++D  G D+F VAVHE GHALGL 
Sbjct: 190 TPFDGEGGFLAHAYFPGPN-IGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLE 248

Query: 243 HSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYG-----KAPQTPYDKPTRKPLAP 297
           HSS P++IM PFYQ    D + + L  DDR G+QQLYG          P  + T +P   
Sbjct: 249 HSSDPSAIMAPFYQWM--DTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSV- 305

Query: 298 PPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLH 357
            P  P +PT+ P+      C+GNFD +A +RGE F FK  WFWR++ + Q++   P  + 
Sbjct: 306 -PDKPKNPTYGPNI-----CDGNFDTVAMLRGEMFVFKERWFWRVR-NNQVMDGYPMPIG 358

Query: 358 RFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELGLP-PGEE 415
           +FW GLPA    +  AY R +DG+ + F G + WVF +  LE G  + + ELG   P ++
Sbjct: 359 QFWRGLPAS---INTAYER-KDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDK 414

Query: 416 VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSP-DDVTVSNAGD 474
           +DA   W  NGKTY  RG +Y+R++E     D  YP+++ +WEG P SP      S+   
Sbjct: 415 IDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVF 474

Query: 475 TYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQC 534
           TYF+KG  YW+F    +K EP  P+    +W+ CP+        RP + T   ET     
Sbjct: 475 TYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS------GGRPDEGTE-EETEVIII 527

Query: 535 ELNQAAGRWPA------PIPLLLLPLLVG 557
           E+++  G   +      P+ LLLL L VG
Sbjct: 528 EVDEEGGGAVSAAAVVLPVLLLLLVLAVG 556


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  370 bits (950), Expect = e-102
 Identities = 202/513 (39%), Positives = 289/513 (56%), Gaps = 39/513 (7%)

Query: 35  WLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPD 94
           WL +YGYLPP  P  + L+S E ++ A+  MQ+F G+  TG++D  T+  M+KPRC +PD
Sbjct: 46  WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105

Query: 95  -VLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMES 153
              G +    RR+RYAL+G  W+ + +T+ +++   + ++     R  +  A   W   +
Sbjct: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNV--TPKVGDPETRKAIRRAFDVWQNVT 163

Query: 154 GLTFHEVDSPQ----GQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHF 209
            LTF EV   +     ++ DI I FA  FH DS PFDG GG LAHA+FPG   I GDTHF
Sbjct: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPG-IGGDTHF 222

Query: 210 DDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQ 269
           D +E WT G+ + +G DLF VAVHE GHALGL HS+ P +IM PFYQ    + D ++L  
Sbjct: 223 DSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQ--YMETDNFKLPN 280

Query: 270 DDRDGLQQLYGKAPQTPYDKPTRK-PLAPP--------------PQPPASPTHSPSFP-- 312
           DD  G+Q++YG   + P   PTR  P  PP              P+PP  PT  PS+P  
Sbjct: 281 DDLQGIQKIYGPPDKIP--PPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGA 338

Query: 313 IPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQA 372
            P+ C+GNF+ +A +R E F FK  WFWR++ + +++   P ++  FW GLP  +  V  
Sbjct: 339 KPNICDGNFNTLAILRREMFVFKDQWFWRVR-NNRVMDGYPMQITYFWRGLPPSIDAVY- 396

Query: 373 AYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTEL--GLPPGEEVDAVFSWPQNGKTY 429
               + DG  + F G ++WVF+D  L+ G    L  L  G+PP   +D+   W   GKTY
Sbjct: 397 ---ENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPP-HGIDSAIWWEDVGKTY 452

Query: 430 LVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTV-SNAGDTYFFKGAHYWRFPK 488
             +G +YWRY E     DPGYP+ +++W+G P SP    V    G TYF+KG  YW+F  
Sbjct: 453 FFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNN 512

Query: 489 NSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPP 521
             +K EP  P+ +  +++ C  P+   +    P
Sbjct: 513 QILKVEPGYPRSILKDFMGCDGPTDRVKEGHSP 545


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  303 bits (776), Expect = 3e-82
 Identities = 202/516 (39%), Positives = 258/516 (50%), Gaps = 49/516 (9%)

Query: 4   RLRLLALLLLLLAPP---ARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRD 60
           R  L  +LLLLL PP   ARA  P A                   H   A+ + P+    
Sbjct: 13  RALLPPMLLLLLQPPPLLARALPPDA-------------------HHLHAERRGPQPWHA 53

Query: 61  AIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTL 120
           A+      A  P T    P   +++R PRC +PD         R++R+ LSG  W+K  L
Sbjct: 54  ALPSSP--APAPATQEA-PRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDL 110

Query: 121 TWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQ 180
           T+R+  FP   QL QE VR  M+ AL  W   + LTF EV   +    DI+IDFAR +H 
Sbjct: 111 TYRILRFPW--QLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRA---DIMIDFARYWHG 165

Query: 181 DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG 240
           D  PFDG GG LAHAFFP  H   GD HFD +ETWT G  D +GTDL  VA HEFGH LG
Sbjct: 166 DDLPFDGPGGILAHAFFPKTHR-EGDVHFDYDETWTIG--DDQGTDLLQVAAHEFGHVLG 222

Query: 241 LGHSSAPNSIMRPFY--QGPVGDPDKYRLSQDDRDGLQQLYGKA-PQTPYDKPTRKPLAP 297
           L H++A  ++M  FY  + P+       LS DD  G+Q LYG+  P      P   P A 
Sbjct: 223 LQHTTAAKALMSAFYTFRYPLS------LSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG 276

Query: 298 PPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLH 357
                 +P   P  P PD CE +FDA++ IRGE FFFK  + WRL+  GQL    PA   
Sbjct: 277 IDTNEIAPLE-PDAP-PDACEASFDAVSTIRGELFFFKAGFVWRLR-GGQLQPGYPALAS 333

Query: 358 RFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVD 417
           R W+GLP+ V    AA+     G I  F G Q+WV+   +   G  PLTELGL       
Sbjct: 334 RHWQGLPSPV---DAAF-EDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHA 389

Query: 418 AVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYF 477
           A+   P+  K Y  RGR YWR+  +  R D   PR  + W G P   D       G  YF
Sbjct: 390 ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYF 449

Query: 478 FKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSS 513
            +G  YW+F    +K     P+ +GP++  C  P++
Sbjct: 450 LRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPAN 485


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  272 bits (695), Expect = 7e-73
 Identities = 154/385 (40%), Positives = 218/385 (56%), Gaps = 36/385 (9%)

Query: 35  WLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPD 94
           WL +YGYLPP  P  + L+S E ++ A+  MQ+F G+  TG++D  T+  M+KPRC +PD
Sbjct: 46  WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105

Query: 95  -VLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMES 153
              G +    RR+RYAL+G  W+ + +T+ +++   + ++     R  +  A   W   +
Sbjct: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNV--TPKVGDPETRKAIRRAFDVWQNVT 163

Query: 154 GLTFHEVDSPQ----GQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHF 209
            LTF EV   +     ++ DI I FA  FH DS PFDG GG LAHA+FPG   I GDTHF
Sbjct: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPG-IGGDTHF 222

Query: 210 DDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQ 269
           D +E WT G+ + +G DLF VAVHE GHALGL HS+ P +IM PFYQ    + D ++L  
Sbjct: 223 DSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQ--YMETDNFKLPN 280

Query: 270 DDRDGLQQLYGKAPQTPYDKPTRK-PLAPP--------------PQPPASPTHSPSFP-- 312
           DD  G+Q++YG   + P   PTR  P  PP              P+PP  PT  PS+P  
Sbjct: 281 DDLQGIQKIYGPPDKIP--PPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGA 338

Query: 313 IPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQA 372
            P+ C+GNF+ +A +R E F FK  WFWR++ + +++   P ++  FW GLP  +  V  
Sbjct: 339 KPNICDGNFNTLAILRREMFVFKDQWFWRVR-NNRVMDGYPMQITYFWRGLPPSIDAVY- 396

Query: 373 AYARHRDGRILLF--SGPQFWVFQD 395
               + DG  + F   G    + QD
Sbjct: 397 ---ENSDGNFVFFKVKGDTLSIIQD 418



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 3/52 (5%)

Query: 429 YLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTVSNAGDTYFFK 479
           ++ + + +WR      R   GYP  ++  W G PPS D V  ++ G+  FFK
Sbjct: 358 FVFKDQWFWRVRNN--RVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  248 bits (634), Expect = 8e-66
 Identities = 163/453 (35%), Positives = 225/453 (49%), Gaps = 45/453 (9%)

Query: 62  IKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLT 121
           I+ MQ+F GL  TG++D  T+  MRKPRC +PDV           R       W+K  LT
Sbjct: 64  IREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDV--------GHFRTFPGIPKWRKTHLT 115

Query: 122 WRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQD 181
           +R+ ++  +  L ++ V   +  AL  W   + LTF  +      E DI+I FA   H D
Sbjct: 116 YRIVNY--TPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEG---EADIMISFAVREHGD 170

Query: 182 SYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGL 241
            YPFDG G  LAHA+ PG   I+GD HFDD+E WT   KD  GT+LF VA HE GH+LGL
Sbjct: 171 FYPFDGPGNVLAHAYAPGPG-INGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHSLGL 226

Query: 242 GHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAP---- 297
            HS+   ++M P Y   + D  ++RLSQDD +G+Q LYG  P +P       PL P    
Sbjct: 227 FHSANTEALMYPLYHS-LTDLTRFRLSQDDINGIQSLYGPPPDSP-----ETPLVPTEPV 280

Query: 298 PPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLH 357
           PP+P       P+         +FDA++ +RGE   FK   FWR   S + + P    + 
Sbjct: 281 PPEPGTPANCDPAL--------SFDAVSTLRGEILIFKDRHFWR--KSLRKLEPELHLIS 330

Query: 358 RFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELGLPPG-EE 415
            FW  LP+    V AAY       + +F G QFW  +  ++  G  R +  LG PP   +
Sbjct: 331 SFWPSLPSG---VDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRK 387

Query: 416 VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDT 475
           +DA  S  +  KTY     +YWR+DE     +PG+P+ ++       S  D      G  
Sbjct: 388 IDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFF 447

Query: 476 YFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 508
           YFF G+    F  N+ K           +WL+C
Sbjct: 448 YFFTGSSQLEFDPNAKKVTHTL---KSNSWLNC 477


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  241 bits (615), Expect = 1e-63
 Identities = 171/496 (34%), Positives = 237/496 (47%), Gaps = 46/496 (9%)

Query: 33  VDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSL 92
           VD+L++YGYL  P       + PE + +A++  Q  + LP +G++D  T A MR+PRC L
Sbjct: 29  VDYLSQYGYLQKPLEGSNNFK-PEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGL 87

Query: 93  PDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGME 152
            D        ++  +Y L G  W+K+ LT+R+ + P  S L   T R  +  A   W   
Sbjct: 88  EDPFN-----QKTLKYLLLGR-WRKKHLTFRILNLP--STLPPHTARAALRQAFQDWSNV 139

Query: 153 SGLTFHEVDSPQGQEPDILIDF-ARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHFDD 211
           + LTF EV   Q    DI + F  R     S  FDG G  LAHA    + P  G  HFD+
Sbjct: 140 APLTFQEV---QAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA----DIPELGSVHFDE 192

Query: 212 EETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDD 271
           +E WT G+    G +L  +A HE GHALGLGHS    ++M P Y+   G    ++L  DD
Sbjct: 193 DEFWTEGTY--RGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYE---GYRPHFKLHPDD 247

Query: 272 RDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDA-IANIRGE 330
             G+Q LYGK  ++P  +   +     P  P  PT  PS P+PD C    DA +   RG+
Sbjct: 248 VAGIQALYGK--KSPVIRDEEEEETELPTVPPVPT-EPS-PMPDPCSSELDAMMLGPRGK 303

Query: 331 TFFFKGPWFWRLQPSGQLVSPRPA-RLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQ 389
           T+ FKG + W +  SG    P P  R+   WEGLP     + AA    R   I  F G +
Sbjct: 304 TYAFKGDYVWTVSDSG----PGPLFRVSALWEGLPGN---LDAAVYSPRTQWIHFFKGDK 356

Query: 390 FWVFQDRQLEGGARPLTELGLPPGEEVDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPG 449
            W + + ++  G         P    +DA   WP N K +L +G  YW++DE A      
Sbjct: 357 VWRYINFKMSPGFPKKLNRVEP---NLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSS 413

Query: 450 YPRDL-SLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 508
           YP+ +  L+ G P  P        G  YFFKG  YWR     ++ E   P+ +  NW+ C
Sbjct: 414 YPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRL-NQQLRVEKGYPRNISHNWMHC 472

Query: 509 ------PAPSSGPRAP 518
                   PS G   P
Sbjct: 473 RPRTIDTTPSGGNTTP 488


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  239 bits (611), Expect = 4e-63
 Identities = 168/496 (33%), Positives = 249/496 (50%), Gaps = 51/496 (10%)

Query: 5   LRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKV 64
           L LL L +    P + A K    +  L   +L +Y Y       Q + +    +   I+ 
Sbjct: 7   LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDSNLIVKKIQG 65

Query: 65  MQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRV 124
           MQ+F GL  TG++D  T+  MRKPRC +PDV   +      +        W+K  LT+R+
Sbjct: 66  MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPK--------WRKTHLTYRI 117

Query: 125 RSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYP 184
            ++  +  L ++ V   +  AL  W   + LTF  +      E DI+I FA   H D Y 
Sbjct: 118 VNY--TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEG---EADIMISFAVKEHGDFYS 172

Query: 185 FDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHS 244
           FDG G +LAHA+ PG   + GD HFDD+E WT   +D  GT+LF VA HE GH+LGL HS
Sbjct: 173 FDGPGHSLAHAYPPGPG-LYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGLFHS 228

Query: 245 SAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPAS 304
           +   ++M P Y     +  ++RLSQDD +G+Q LYG  P +     T +PL P    P+ 
Sbjct: 229 ANTEALMYPLYNS-FTELAQFRLSQDDVNGIQSLYGPPPAS-----TEEPLVPTKSVPSG 282

Query: 305 PTHSPSFPIPDRCEG--NFDAIANIRGETFFFKGPWFWRL-----QPSGQLVSPRPARLH 357
                   +P +C+   +FDAI+ +RGE  FFK  +FWR      +P   L+S       
Sbjct: 283 S------EMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLIS------- 329

Query: 358 RFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELGLPPG-EE 415
            FW  LP+    + AAY  +    + +F G +FW  +  +++ G  R +  LG PP   +
Sbjct: 330 AFWPSLPS---YLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRK 386

Query: 416 VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTVSNAGD 474
           +DA  S  +  KTY     +YWR+DE +   + G+PR ++  + G  P  D V +   G 
Sbjct: 387 IDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAV-LQAFGF 445

Query: 475 TYFFKGAHYWRFPKNS 490
            YFF G+  + F  N+
Sbjct: 446 FYFFSGSSQFEFDPNA 461


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  236 bits (601), Expect = 5e-62
 Identities = 167/508 (32%), Positives = 238/508 (46%), Gaps = 44/508 (8%)

Query: 7   LLALLLLLLAPP--ARAPKPSAQDVSLGVDWLTRYGYLPPPHP-AQAQLQSPEKLRDAIK 63
           ++AL     AP   A +P+    +  L   +L +Y      H   +   +    +   IK
Sbjct: 14  IMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNSMIRKIK 73

Query: 64  VMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWR 123
            +Q F GL  TG++D  T+  ++KPRC +PDV           R       WKK TLT+R
Sbjct: 74  ELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANY--------RLFPGEPKWKKNTLTYR 125

Query: 124 VRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSY 183
           +  +  S  +S   V   +  AL AW     L+F  ++S    E DI+I F    H DSY
Sbjct: 126 ISKYTPS--MSSVEVDKAVEMALQAWSSAVPLSFVRINSG---EADIMISFENGDHGDSY 180

Query: 184 PFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGH 243
           PFDG  GTLAHAF PGE  + GDTHFD+ E WT G+    G +LF VA HEFGHALGL H
Sbjct: 181 PFDGPRGTLAHAFAPGE-GLGGDTHFDNAEKWTMGT---NGFNLFTVAAHEFGHALGLAH 236

Query: 244 SSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPA 303
           S+ P+++M P Y+    +P  + L +DD  G+Q LYG           RK     P  P 
Sbjct: 237 STDPSALMYPTYK--YKNPYGFHLPKDDVKGIQALYG----------PRKVFLGKPTLPH 284

Query: 304 SPTHSPSFPIPDRCE--GNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWE 361
           +P H PS  IPD C+   +FDA+  +  E   FK   FWR Q   +    RP+ +     
Sbjct: 285 APHHKPS--IPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLR-TGIRPSTI---TS 338

Query: 362 GLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPG-EEVDAVF 420
             P  +  V AAY     G    F GP +W+ +  Q++G  R + + G P   +++DA  
Sbjct: 339 SFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQGPPRTIYDFGFPRHVQQIDAAV 398

Query: 421 SWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKG 480
              +  KT    G +Y+ YDE   + +  YP++            D  V   G  YFF G
Sbjct: 399 YLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSG 458

Query: 481 AHYWRFPKNSIKTEPDAPQPMGPNWLDC 508
              +++     + E         +W+ C
Sbjct: 459 PKTYKY---DTEKEDVVSVVKSSSWIGC 483


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  233 bits (595), Expect = 3e-61
 Identities = 177/511 (34%), Positives = 239/511 (46%), Gaps = 57/511 (11%)

Query: 5   LRLLALLLLLLAPPARAPKPSAQDVSLGV--DWLTRYGYLPPPHPAQAQLQSPEKLRDAI 62
           L+ L  LLLL    ++A   S+++ +     D+L ++  LP       +      + + +
Sbjct: 4   LKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKL 63

Query: 63  KVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTW 122
           K MQRF GL  TG+ +  T+  M+KPRC +PD  G                 W++  LT+
Sbjct: 64  KEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFM--------LTPGNPKWERTNLTY 115

Query: 123 RVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDS 182
           R+R++  + QLS+  V   +  A   W + S L F  +   QG E DI I F +  H D+
Sbjct: 116 RIRNY--TPQLSEAEVERAIKDAFELWSVASPLIFTRIS--QG-EADINIAFYQRDHGDN 170

Query: 183 YPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLG 242
            PFDG  G LAHAF PG+  I GD HFD EETWT  S +    +LF VA HEFGH+LGL 
Sbjct: 171 SPFDGPNGILAHAFQPGQG-IGGDAHFDAEETWTNTSAN---YNLFLVAAHEFGHSLGLA 226

Query: 243 HSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPP 302
           HSS P ++M P Y     +   Y L QDD DG+Q +YG +                   P
Sbjct: 227 HSSDPGALMYPNY--AFRETSNYSLPQDDIDGIQAIYGLSSN-----------------P 267

Query: 303 ASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEG 362
             PT  PS P P      FDAI  +RGE  FFK  +FWR  P  Q V      L  FW  
Sbjct: 268 IQPT-GPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISL--FWPS 324

Query: 363 LPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQ-LEGGARPLTELGLPPG-EEVDAVF 420
           LP     +QAAY       I LF G Q+W       L+G  + ++  G P   + +DA  
Sbjct: 325 LPTG---IQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAV 381

Query: 421 SWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPP---SPDDVTVSNAGDTYF 477
            +    KTY     Q+WRYD      +PGYP+ +S   GA P   S  D         + 
Sbjct: 382 FY--RSKTYFFVNDQFWRYDNQRQFMEPGYPKSIS---GAFPGIESKVDAVFQQEHFFHV 436

Query: 478 FKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 508
           F G  Y+ F   + +    A    G  WL+C
Sbjct: 437 FSGPRYYAFDLIAQRVTRVA---RGNKWLNC 464


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  227 bits (578), Expect = 3e-59
 Identities = 162/492 (32%), Positives = 235/492 (47%), Gaps = 59/492 (11%)

Query: 10  LLLLLLAPPARAPKPSAQDVSL-------GVDWLTR-YGYLPPPHPAQAQLQSPEKLRDA 61
           LL+LLL   A    P     SL       G  +L + YG      P      S   +++ 
Sbjct: 4   LLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEK 63

Query: 62  IKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLT 121
           I+ MQ F GL  TG++D  T+  M  PRC +PDV           R    G VW+K  +T
Sbjct: 64  IQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDV--------HHFREMPGGPVWRKHYIT 115

Query: 122 WRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQD 181
           +R+ ++  +  +++E V   +  A   W   + L F ++++      DIL+ FAR  H D
Sbjct: 116 YRINNY--TPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMA---DILVVFARGAHGD 170

Query: 182 SYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGL 241
            + FDG GG LAHAF PG   I GD HFD++E WT  S    GT+LF  AVHE GH+LGL
Sbjct: 171 FHAFDGKGGILAHAFGPGSG-IGGDAHFDEDEFWTTHSG---GTNLFLTAVHEIGHSLGL 226

Query: 242 GHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQP 301
           GHSS P ++M P Y+    D + +RLS DD  G+Q LYG         P      P P  
Sbjct: 227 GHSSDPKAVMFPTYK--YVDINTFRLSADDIRGIQSLYG--------DPKENQRLPNPDN 276

Query: 302 PASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPAR----LH 357
                  P+         +FDA+  +  + FFFK  +FW        VS RP      + 
Sbjct: 277 SEPALCDPNL--------SFDAVTTVGNKIFFFKDRFFW------LKVSERPKTSVNLIS 322

Query: 358 RFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELGLPP-GEE 415
             W  LP+    ++AAY      ++ LF   ++W+  + + E    + +   G P   ++
Sbjct: 323 SLWPTLPSG---IEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKK 379

Query: 416 VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSL-WEGAPPSPDDVTVSNAGD 474
           +DA    P+  +TY     QYWRYDE     DPGYP+ ++  ++G  P  D V  S    
Sbjct: 380 IDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKY 439

Query: 475 TYFFKGAHYWRF 486
            YFF+G++ + +
Sbjct: 440 YYFFQGSNQFEY 451


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  225 bits (574), Expect = 7e-59
 Identities = 159/462 (34%), Positives = 215/462 (46%), Gaps = 53/462 (11%)

Query: 25  SAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVAT 84
           S +D+     +L  Y Y P       +  +   + + ++ MQ F GL  TG++D  T+  
Sbjct: 32  SEEDLQFAERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDV 90

Query: 85  MRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSY 144
           M+KPRC +PDV G   +  R  +       W K  LT+R+ ++  +  ++   V      
Sbjct: 91  MKKPRCGVPDV-GEYNVFPRTLK-------WSKMNLTYRIVNY--TPDMTHSEVEKAFKK 140

Query: 145 ALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPIS 204
           A   W   + L F  +        DI+I F    H D YPFDG  G LAHAF PG +   
Sbjct: 141 AFKVWSDVTPLNFTRLHDGIA---DIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPN-YG 196

Query: 205 GDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDK 264
           GD HFDD+ETWT  SK   G +LF VA HEFGH+LGL HS  P ++M P Y         
Sbjct: 197 GDAHFDDDETWTSSSK---GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY--TYTGKSH 251

Query: 265 YRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEG--NFD 322
           + L  DD  G+Q LYG   + P                 +P H  +   PD+C+   + D
Sbjct: 252 FMLPDDDVQGIQSLYGPGDEDP-----------------NPKHPKT---PDKCDPSLSLD 291

Query: 323 AIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRI 382
           AI ++RGET  FK  +FWRL P  Q V         FW  LP +   + AAY       I
Sbjct: 292 AITSLRGETMIFKDRFFWRLHP--QQVDAELFLTKSFWPELPNR---IDAAYEHPSHDLI 346

Query: 383 LLFSGPQFWVFQDRQ-LEGGARPLTELGLPPG-EEVDAVFSWPQNGKTYLVRGRQYWRYD 440
            +F G +FW       LEG  + ++ELGLP   +++ A   +   GKT L  G Q WRYD
Sbjct: 347 FIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYD 406

Query: 441 EAAARPDPGYPRDLSLWEGAPPSPD--DVTVSNAGDTYFFKG 480
           +     D  YPR +   E  P   D  D      G  YFF G
Sbjct: 407 DTNHIMDKDYPRLIE--EDFPGIGDKVDAVYEKNGYIYFFNG 446


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  207 bits (527), Expect = 2e-53
 Identities = 157/487 (32%), Positives = 223/487 (45%), Gaps = 54/487 (11%)

Query: 27  QDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMR 86
           QDV L   +L +Y  L        + ++   + + +K MQ F GL  TG+ D  T+  M+
Sbjct: 29  QDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMK 88

Query: 87  KPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYAL 146
           +PRC +PDV          R        W++  LT+R+ ++  +  L +  V   +  A 
Sbjct: 89  QPRCGVPDVAQFVLTEGNPR--------WEQTHLTYRIENY--TPDLPRADVDHAIEKAF 138

Query: 147 MAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGD 206
             W   + LTF +V   Q    DI+I F R  H+D+ PFDG GG LAHAF PG   I GD
Sbjct: 139 QLWSNVTPLTFTKVSEGQA---DIMISFVRGDHRDNSPFDGPGGNLAHAFQPGP-GIGGD 194

Query: 207 THFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYR 266
            HFD++E WT   ++    +L  VA HE GH+LGL HS+   ++M P Y    GD    +
Sbjct: 195 AHFDEDERWTNNFRE---YNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFS-GD---VQ 247

Query: 267 LSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEG--NFDAI 324
           L+QDD DG+Q +YG++               P QP    T       P  C+    FDAI
Sbjct: 248 LAQDDIDGIQAIYGRSQN-------------PVQPIGPQT-------PKACDSKLTFDAI 287

Query: 325 ANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILL 384
             IRGE  FFK  ++ R  P    V      +  FW  LP     ++AAY       +  
Sbjct: 288 TTIRGEVMFFKDRFYMRTNPFYPEVELN--FISVFWPQLP---NGLEAAYEFADRDEVRF 342

Query: 385 FSGPQFWVFQDRQ-LEGGARPL-TELGLP-PGEEVDAVFSWPQNGKTYLVRGRQYWRYDE 441
           F G ++W  Q +  L G  + + +  G P   + +DA  S    GKTY     +YWRYDE
Sbjct: 343 FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDE 402

Query: 442 AAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPM 501
                DPGYP+ ++          D      G  YFF G   ++F     KT+       
Sbjct: 403 YKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDP---KTKRILTLQK 459

Query: 502 GPNWLDC 508
             +W +C
Sbjct: 460 ANSWFNC 466


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  207 bits (526), Expect = 3e-53
 Identities = 165/542 (30%), Positives = 238/542 (43%), Gaps = 58/542 (10%)

Query: 2   RLRLRLLALLLLLLAP-PARAPKPSAQDVSLGVD-WLTRYGYLPPPHPAQAQLQSPEKLR 59
           R+ L L AL LLL     A+  +   Q++    + +L +YGYL    P   +  +  +  
Sbjct: 4   RVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVP---KAPTSTRFS 60

Query: 60  DAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGL--------------VRRR 105
           DAI+  Q  + LP +G +D  T+  M +PRC + D    A                +RR+
Sbjct: 61  DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK 120

Query: 106 RRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQG 165
           +R+A  G+ W K+ L++R+ ++P+   L +  VR  +  A   W   S L F E  +P  
Sbjct: 121 KRFAKQGNKWYKQHLSYRLVNWPE--HLPEPAVRGAVRAAFQLWSNVSALEFWE--APAT 176

Query: 166 QEPDILIDFARAFHQDSY--PFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGE 223
              DI + F +  H D     FDG GG LAHAF P      G+ HFD +E W+   +   
Sbjct: 177 GPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRR----GEAHFDQDERWSLSRR--R 230

Query: 224 GTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGK-- 281
           G +LF V  HE GH LGL HS AP ++M P+Y+    D     LS DD   +Q LYGK  
Sbjct: 231 GRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDA---LLSWDDVLAVQSLYGKPL 287

Query: 282 ----APQTP----YDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAI-ANIRGETF 332
               A Q P     D  T    +P  + P   T  P +     C  +FDAI  + + + +
Sbjct: 288 GGSVAVQLPGKLFTDFETWDSYSPQGRRP--ETQGPKY-----CHSSFDAITVDRQQQLY 340

Query: 333 FFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWV 392
            FKG  FW +   G +  PRP  L   W GLP     ++AA     DG    F G + W 
Sbjct: 341 IFKGSHFWEVAADGNVSEPRP--LQERWVGLPPN---IEAAAVSLNDGDFYFFKGGRCWR 395

Query: 393 FQDRQLEGGARPLTELGLPPGEEVDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPR 452
           F+  +   G   L   G  P    DA   +P   +  L +G +Y+       + +P YPR
Sbjct: 396 FRGPKPVWGLPQLCRAGGLP-RHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPR 454

Query: 453 DLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPS 512
            L  W G P           G   FF+   YWR  +  ++            W+ C   +
Sbjct: 455 SLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGCWHAN 514

Query: 513 SG 514
           SG
Sbjct: 515 SG 516


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  206 bits (523), Expect = 6e-53
 Identities = 165/517 (31%), Positives = 235/517 (45%), Gaps = 54/517 (10%)

Query: 2   RLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDA 61
           RL L  L  +    A P      + +++ L   +L ++  L        Q ++   + D 
Sbjct: 3   RLLLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDK 62

Query: 62  IKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLT 121
           I+ MQ F GL  TG++D  T+  M+ PRC +PDV G  G       Y L G  W+K  LT
Sbjct: 63  IREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDV-GQYG-------YTLPG--WRKYNLT 112

Query: 122 WRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFH-Q 180
           +R+ ++  +  +++  V   +   L  W   + L F ++        DI+I F    H +
Sbjct: 113 YRIINY--TPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIA---DIMIAFRTRVHGR 167

Query: 181 DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG 240
               FDG  G L HAF PG   + GDTHFD++E WT   KDG G +LF VA HEFGHALG
Sbjct: 168 CPRYFDGPLGVLGHAFPPGPG-LGGDTHFDEDENWT---KDGAGFNLFLVAAHEFGHALG 223

Query: 241 LGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQ 300
           L HS+   ++M P Y     DP KY LSQDD +G+Q +YG  P+ P         A P +
Sbjct: 224 LSHSNDQTALMFPNYVSL--DPRKYPLSQDDINGIQSIYGGLPKEP---------AKPKE 272

Query: 301 PPASPTHSPSFPIPDRCEGN--FDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHR 358
           P           IP  C+ +  FDAI   R E  FFKG   WR+     +       +  
Sbjct: 273 P----------TIPHACDPDLTFDAITTFRREVMFFKGRHLWRIY--YDITDVEFELIAS 320

Query: 359 FWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQD-RQLEGGARPLTELGLPPG-EEV 416
           FW  LPA    +QAAY   RD +IL+F    FW+ +    L    + +  LG P   +++
Sbjct: 321 FWPSLPAD---LQAAYENPRD-KILVFKDENFWMIRGYAVLPDYPKSIHTLGFPGRVKKI 376

Query: 417 DAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTY 476
           DA        KTY   G   WR+DE     D G+P+ +           D      G  +
Sbjct: 377 DAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAFQYKGFFF 436

Query: 477 FFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSS 513
           F +G+  + +    IKT+          W  C  P +
Sbjct: 437 FSRGSKQFEY---DIKTKNITRIMRTNTWFQCKEPKN 470


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  201 bits (512), Expect = 1e-51
 Identities = 149/449 (33%), Positives = 207/449 (46%), Gaps = 54/449 (12%)

Query: 65  MQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRV 124
           MQ F GL  TG+ D  T+  M++PRC +PDV          R        W++  LT+R+
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPR--------WEQTHLTYRI 52

Query: 125 RSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYP 184
            ++  +  L +  V   +  A   W   + LTF +V   Q    DI+I F R  H+D+ P
Sbjct: 53  ENY--TPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQA---DIMISFVRGDHRDNSP 107

Query: 185 FDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHS 244
           FDG GG LAHAF PG   I GD HFD++E WT   ++    +L  VA HE GH+LGL HS
Sbjct: 108 FDGPGGNLAHAFQPGP-GIGGDAHFDEDERWTNNFRE---YNLHRVAAHELGHSLGLSHS 163

Query: 245 SAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPAS 304
           +   ++M P Y    GD    +L+QDD DG+Q +YG++               P QP   
Sbjct: 164 TDIGALMYPSYTFS-GD---VQLAQDDIDGIQAIYGRSQN-------------PVQPIGP 206

Query: 305 PTHSPSFPIPDRCEG--NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEG 362
            T       P  C+    FDAI  IRGE  FFK  ++ R  P    V      +  FW  
Sbjct: 207 QT-------PKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELN--FISVFWPQ 257

Query: 363 LPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQ-LEGGARPL-TELGLP-PGEEVDAV 419
           LP     ++AAY       +  F G ++W  Q +  L G  + + +  G P   + +DA 
Sbjct: 258 LP---NGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAA 314

Query: 420 FSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFK 479
            S    GKTY     +YWRYDE     DPGYP+ ++          D      G  YFF 
Sbjct: 315 LSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFH 374

Query: 480 GAHYWRFPKNSIKTEPDAPQPMGPNWLDC 508
           G   ++F     KT+         +W +C
Sbjct: 375 GTRQYKFDP---KTKRILTLQKANSWFNC 400


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  188 bits (478), Expect = 1e-47
 Identities = 114/312 (36%), Positives = 164/312 (52%), Gaps = 42/312 (13%)

Query: 208 HFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRL 267
           ++DD+  W F     +G  LF VA HEFGHA+GL HS  P ++M P Y         +RL
Sbjct: 330 NYDDDRKWGFCPD--QGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT----KNFRL 383

Query: 268 SQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGN--FDAIA 325
           SQDD  G+Q+LYG +P           L   P P   P        P+ C+ +  FD IA
Sbjct: 384 SQDDIKGIQELYGASPDID--------LGTGPTPTLGPV------TPEICKQDIVFDGIA 429

Query: 326 NIRGETFFFKGPWFWRLQPSGQLVSPR-----PARLHRFWEGLPAQVRVVQAAYARHRDG 380
            IRGE FFFK  + WR       V+PR     P  +  FW  LP ++    A Y   ++ 
Sbjct: 430 QIRGEIFFFKDRFIWRT------VTPRDKPMGPLLVATFWPELPEKI---DAVYEAPQEE 480

Query: 381 RILLFSGPQFWVFQDRQLEGG-ARPLTELGLPPG-EEVDAVFSWPQNGKTYLVRGRQYWR 438
           + + F+G ++W++    LE G  +PLT LGLPP  + VDA F+W +N KTY+  G ++WR
Sbjct: 481 KAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR 540

Query: 439 YDEAAARPDPGYPRDLS-LWEGAPPSPDDVT-VSNAGDTYFFKGAHYWRFPKNSIKTEPD 496
           Y+E   + DPG+P+ ++  W   P + D V  +   G +YFFKGA+Y +    S+K+   
Sbjct: 541 YNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF 600

Query: 497 APQPMGPNWLDC 508
               +  +WL C
Sbjct: 601 G--SIKSDWLGC 610



 Score =  121 bits (304), Expect = 1e-27
 Identities = 67/161 (41%), Positives = 88/161 (54%), Gaps = 14/161 (8%)

Query: 58  LRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKK 117
           L+D +K MQ+F GLP+TG +D  T+ TMRKPRC  PDV       R+ +        W K
Sbjct: 20  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPK--------WDK 71

Query: 118 RTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARA 177
             +T+R+  +  +  L  ETV    + A   W   + L F  +      E DI+I+F R 
Sbjct: 72  NQITYRIIGY--TPDLDPETVDDAFARAFQVWSDVTPLRFSRI---HDGEADIMINFGRW 126

Query: 178 FHQDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFG 218
            H D YPFDG  G LAHAF PG   + GD+HFDD+E WT G
Sbjct: 127 EHGDGYPFDGKDGLLAHAFAPGT-GVGGDSHFDDDELWTLG 166


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  188 bits (478), Expect = 1e-47
 Identities = 114/312 (36%), Positives = 164/312 (52%), Gaps = 42/312 (13%)

Query: 208 HFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRL 267
           ++DD+  W F     +G  LF VA HEFGHA+GL HS  P ++M P Y         +RL
Sbjct: 380 NYDDDRKWGFCPD--QGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT----KNFRL 433

Query: 268 SQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGN--FDAIA 325
           SQDD  G+Q+LYG +P           L   P P   P        P+ C+ +  FD IA
Sbjct: 434 SQDDIKGIQELYGASPDID--------LGTGPTPTLGPV------TPEICKQDIVFDGIA 479

Query: 326 NIRGETFFFKGPWFWRLQPSGQLVSPR-----PARLHRFWEGLPAQVRVVQAAYARHRDG 380
            IRGE FFFK  + WR       V+PR     P  +  FW  LP ++    A Y   ++ 
Sbjct: 480 QIRGEIFFFKDRFIWRT------VTPRDKPMGPLLVATFWPELPEKI---DAVYEAPQEE 530

Query: 381 RILLFSGPQFWVFQDRQLEGG-ARPLTELGLPPG-EEVDAVFSWPQNGKTYLVRGRQYWR 438
           + + F+G ++W++    LE G  +PLT LGLPP  + VDA F+W +N KTY+  G ++WR
Sbjct: 531 KAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR 590

Query: 439 YDEAAARPDPGYPRDLS-LWEGAPPSPDDVT-VSNAGDTYFFKGAHYWRFPKNSIKTEPD 496
           Y+E   + DPG+P+ ++  W   P + D V  +   G +YFFKGA+Y +    S+K+   
Sbjct: 591 YNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF 650

Query: 497 APQPMGPNWLDC 508
               +  +WL C
Sbjct: 651 G--SIKSDWLGC 660



 Score =  129 bits (323), Expect = 9e-30
 Identities = 83/217 (38%), Positives = 110/217 (50%), Gaps = 17/217 (7%)

Query: 5   LRLLALLLLLLAPPARAPKPSAQ---DVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDA 61
           LR L LL  LL+  A AP P  +   DV+   D      YL   +    +  +   L+D 
Sbjct: 14  LRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDT 73

Query: 62  IKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLT 121
           +K MQ+F GLP+TG +D  T+ TMRKPRC  PDV       R+ +        W K  +T
Sbjct: 74  LKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPK--------WDKNQIT 125

Query: 122 WRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQD 181
           +R+  +  +  L  ETV    + A   W   + L F  +      E DI+I+F R  H D
Sbjct: 126 YRIIGY--TPDLDPETVDDAFARAFQVWSDVTPLRFSRI---HDGEADIMINFGRWEHGD 180

Query: 182 SYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFG 218
            YPFDG  G LAHAF PG   + GD+HFDD+E WT G
Sbjct: 181 GYPFDGKDGLLAHAFAPGT-GVGGDSHFDDDELWTLG 216


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  180 bits (457), Expect = 3e-45
 Identities = 112/280 (40%), Positives = 151/280 (53%), Gaps = 23/280 (8%)

Query: 5   LRLLALLLLLLAPPARA-PKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIK 63
           +RL  L  + L P + A P P        + W     YL   +   ++ ++   L   +K
Sbjct: 1   MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK 60

Query: 64  VMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYAL--SGSVWKKRTLT 121
            MQ+F GLP TG ++   +  M+KPRC +PDV            Y+L  +   W  + +T
Sbjct: 61  EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVA----------EYSLFPNSPKWTSKVVT 110

Query: 122 WRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQD 181
           +R+ S+ +   L   TV  L+S AL  WG E  L F +V        DI+I FAR  H D
Sbjct: 111 YRIVSYTRD--LPHITVDRLVSKALNMWGKEIPLHFRKV---VWGTADIMIGFARGAHGD 165

Query: 182 SYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGL 241
           SYPFDG G TLAHAF PG   + GD HFD++E WT GS    G +    A HE GH+LG+
Sbjct: 166 SYPFDGPGNTLAHAFAPGT-GLGGDAHFDEDERWTDGS--SLGINFLYAATHELGHSLGM 222

Query: 242 GHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGK 281
           GHSS PN++M P Y    GDP  ++LSQDD  G+Q+LYGK
Sbjct: 223 GHSSDPNAVMYPTYGN--GDPQNFKLSQDDIKGIQKLYGK 260


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  135 bits (341), Expect = 8e-32
 Identities = 145/545 (26%), Positives = 214/545 (39%), Gaps = 115/545 (21%)

Query: 18  PARAPKPSAQDVSLGVDWLTRYGYLP------PPHPAQAQLQSPEKLRDAIKVMQRFAGL 71
           P R  KP A D+     +L+RYG+        P      +      L +A++  QR   L
Sbjct: 40  PLRQAKPIA-DLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANAL 98

Query: 72  PETGRMDPGTVATMRKPRCSLPDVL-----------GVAGLVRRRRR----YALSGSVWK 116
           P +G +D  T+A M +PRC +PD+            G     R RR      +LS   W+
Sbjct: 99  PASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQ 158

Query: 117 --------------KRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDS 162
                         KRTL+WR+     SSQLS    R +++ A   W   + L F E  +
Sbjct: 159 PRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLA 218

Query: 163 PQGQEPDILIDFARAFHQD-SYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKD 221
             G   DI + F R  H      FDG G   AHA+        GD HFDD+E +T  + D
Sbjct: 219 APGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAW------RLGDIHFDDDEHFTPPTSD 272

Query: 222 GEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGK 281
             G  L  VAVHE GH LGL H+    SIM+P Y   +     + L   DR  +Q+LYG 
Sbjct: 273 -TGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNY---IPQEPAFELDWSDRKAIQKLYGS 328

Query: 282 APQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAIAN-------------IR 328
                                              CEG+FD   +             +R
Sbjct: 329 -----------------------------------CEGSFDTAFDWIRKERNQYGEVMVR 353

Query: 329 GETFFFKGPWFWRLQ-PSGQLVSPRPARLHRFWEGLPA-QVRVVQAAYARHRDGRILLFS 386
             T+FF+  W+W  +  + +     P ++   W G+P   +      +   RD R   F 
Sbjct: 354 FSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDER-YFFQ 412

Query: 387 GPQFWVF---QDRQL----EGGARP-LTELGLPP-GEEVDAVFSWPQNGKTYLVRGRQYW 437
           G Q+W +   +D+ L    +G + P L   G P     +D  F   +    Y  +    +
Sbjct: 413 GNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVF 472

Query: 438 RYDEAAARPDPGYPRDLS-LWEGAPP------SPDDVTVSNA-GDTYFFKGAHYWRFPKN 489
            +D    R    YP+ ++ ++    P      + D    S A    +FFKG  YW+   +
Sbjct: 473 AFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVND 532

Query: 490 SIKTE 494
             K +
Sbjct: 533 KDKQQ 537


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  134 bits (337), Expect = 2e-31
 Identities = 104/342 (30%), Positives = 145/342 (42%), Gaps = 52/342 (15%)

Query: 207 THFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYR 266
           ++FD ++ W F     +G  LF VA HEFGHALGL HSS P ++M P Y+   G P    
Sbjct: 377 SNFDSDKKWGFCPD--QGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPP---- 430

Query: 267 LSQDDRDGLQQLYGKAPQT---------------------------PYDKPTRKPLAPPP 299
           L +DD +G++ LYG  P+                            P ++PT  P  PP 
Sbjct: 431 LHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPS 490

Query: 300 QPPASP--------THSPSFPIPDRCEGN-FDAIANIRGETFFFKGPWFWRLQPSGQLVS 350
             P  P        T  P  P+ D C  N FDAIA I  + + FK   +WR         
Sbjct: 491 AGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRP 550

Query: 351 PRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGL 410
             P  +   W  LP   R + + +      ++  FSG Q WV+    +  G R L +LGL
Sbjct: 551 QGPFLIADKWPALP---RKLDSVFEERLSKKLFFFSGRQVWVYTGASVL-GPRRLDKLGL 606

Query: 411 PPGEEVDAVFSWPQN--GKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDV 467
             G +V  V    ++  GK  L  GR+ WR+D  A   DP    ++  ++ G P    DV
Sbjct: 607 --GADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDV 664

Query: 468 TVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCP 509
                   YF +   YWR    S   + D    +  + L CP
Sbjct: 665 -FQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCP 705



 Score =  106 bits (265), Expect = 5e-23
 Identities = 69/193 (35%), Positives = 98/193 (50%), Gaps = 22/193 (11%)

Query: 28  DVSLGVDWLTRYGYLPPPHPAQAQLQSPEK-LRDAIKVMQRFAGLPETGRMDPGTVATMR 86
           D  L  ++L RYGY        A+++   K L  A+ ++Q+   LPETG +D  T+  MR
Sbjct: 41  DRQLAEEYLYRYGYT-----RVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMR 95

Query: 87  KPRCSLPDVLGVAGLVRRRRRYALSGSV-WKKRTLTWRVRSFPQSSQLSQETVRVLMSYA 145
            PRC +PD+          R     G + W    +T+ ++++  S  L +  +    + A
Sbjct: 96  TPRCGVPDL---------GRFQTFEGDLKWHHHNITYWIQNY--SEDLPRAVIDDAFARA 144

Query: 146 LMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISG 205
              W   + LTF  V S   ++ DI+I F  A H D YPFDG  G LAHAF PG   I G
Sbjct: 145 FALWSAVTPLTFTRVYS---RDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGP-GIQG 200

Query: 206 DTHFDDEETWTFG 218
           D HFDD+E W+ G
Sbjct: 201 DAHFDDDELWSLG 213


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  113 bits (282), Expect = 5e-25
 Identities = 75/208 (36%), Positives = 103/208 (49%), Gaps = 19/208 (9%)

Query: 74  TGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQL 133
           T  +D    A + +P C +PD    +    R +        W K TLT+R+ ++P   + 
Sbjct: 66  TDLLDMQMHALLHQPHCGVPDGSDTSISPGRCK--------WNKHTLTYRIINYPHDMKP 117

Query: 134 SQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLA 193
           S   V+  +  A+  W   + L F +V   Q  + DI + F +  H+D +PFDG GG L 
Sbjct: 118 S--AVKDSIYNAVSIWSNVTPLIFQQV---QNGDADIKVSFWQWAHEDGWPFDGPGGILG 172

Query: 194 HAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRP 253
           HAF P      G  HFD  E W   S    G +LF VA HE GH+LGL HS   +SIM P
Sbjct: 173 HAFLPNSGN-PGVVHFDKNEHW---SASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYP 228

Query: 254 FYQGPVGDPDKYRLSQDDRDGLQQLYGK 281
            Y     DP  ++LS DD   +Q LYG+
Sbjct: 229 TYW--YHDPRTFQLSADDIQRIQHLYGE 254


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 78/196 (39%), Positives = 96/196 (48%), Gaps = 29/196 (14%)

Query: 101 LVRRRRRYALSGSV--WKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFH 158
           L  RRRRY L+ +   W    LT+R+ SFP++    +ET R L + A   W   S  +F 
Sbjct: 72  LAPRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAA-AFRMWSDVSPFSFR 130

Query: 159 EVDSPQGQEPDILIDFARAFHQDS------YPFDGLGGTLAHAFFPGEHPISGDTHFDDE 212
           EV +P+ Q  D+ I F    H D       + FDG  G LAHAFFP      G  HFDD 
Sbjct: 131 EV-APE-QPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPH----GGIHFDDS 184

Query: 213 ETWTFGS-----KDGEG-TDLFAVAVHEFGHALGLGHSSAPNSIM--RPFYQGPVGDPDK 264
           E W  G      K G   TDL  VA HE GHALGL HS    ++M      +G       
Sbjct: 185 EYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRG------W 238

Query: 265 YRLSQDDRDGLQQLYG 280
             LSQD+  GL +LYG
Sbjct: 239 KALSQDELWGLHRLYG 254


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 55/158 (34%), Positives = 79/158 (50%), Gaps = 13/158 (8%)

Query: 33  VDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSL 92
           VD+L++YGYL  P       + PE + +A++  Q  + LP +G++D  T A MR+PRC L
Sbjct: 29  VDYLSQYGYLQKPLEGSNNFK-PEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGL 87

Query: 93  PDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGME 152
            D        ++  +Y L G  W+K+ LT+R+ + P  S L   T R  +  A   W   
Sbjct: 88  EDPFN-----QKTLKYLLLGR-WRKKHLTFRILNLP--STLPPHTARAALRQAFQDWSNV 139

Query: 153 SGLTFHEVDSPQGQEPDILIDF-ARAFHQDSYPFDGLG 189
           + LTF EV   Q    DI + F  R     S  FDG G
Sbjct: 140 APLTFQEV---QAGAADIRLSFHGRQSSYCSNTFDGPG 174


>gi|88853069 vitronectin precursor [Homo sapiens]
          Length = 478

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 45/158 (28%), Positives = 69/158 (43%), Gaps = 20/158 (12%)

Query: 343 QPSGQLVSPRPARLHRFWEGLPAQVRVVQA----AYARHRDGRILLFSGPQFWVFQDRQL 398
           +P G  +  RP  LH      PA+  +       A+   ++G +  F G   +   ++ +
Sbjct: 131 KPEG--IDSRPETLHPGRPQPPAEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDEKAV 188

Query: 399 EGGARPLTELGLPPGEEVDAVFSWPQ-NGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLW 457
             G   L          +DA F+     GKTYL +G QYWR+++     DP YPR++S  
Sbjct: 189 RPGYPKLIRDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVL--DPDYPRNIS-- 244

Query: 458 EGAPPSPDDV---------TVSNAGDTYFFKGAHYWRF 486
           +G    PD+V         + S     YFFKG  YW +
Sbjct: 245 DGFDGIPDNVDAALALPAHSYSGRERVYFFKGKQYWEY 282



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 6/82 (7%)

Query: 318 EGNFDAI---ANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAY 374
           EG  DA     N +G+T+ FKG  +WR +  G L    P  +   ++G+P  V    A  
Sbjct: 203 EGPIDAAFTRINCQGKTYLFKGSQYWRFE-DGVLDPDYPRNISDGFDGIPDNVDAALALP 261

Query: 375 ARHRDG--RILLFSGPQFWVFQ 394
           A    G  R+  F G Q+W +Q
Sbjct: 262 AHSYSGRERVYFFKGKQYWEYQ 283



 Score = 29.6 bits (65), Expect = 7.7
 Identities = 13/39 (33%), Positives = 20/39 (51%), Gaps = 3/39 (7%)

Query: 476 YFFKGAHYWRFPKNSIKTE---PDAPQPMGPNWLDCPAP 511
           +FF G  Y+R    + + +   P  P+ +   WL CPAP
Sbjct: 437 FFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCPAP 475


>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 36/85 (42%), Positives = 42/85 (49%), Gaps = 5/85 (5%)

Query: 133 LSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFA-RAFHQDSYPFDGLGGT 191
           L QE V      A   W   S LTF      +G   DI++ F   A   D+ PF G  G 
Sbjct: 33  LPQEDVDRATGKAFELWSKASALTFTRDFESEG---DIILSFVFLADLHDNSPFYGHDGC 89

Query: 192 LAHAFFPGEHPISGDTHFDDEETWT 216
           LAHAF PG   I GD HFD++ET T
Sbjct: 90  LAHAFPPGP-GIGGDVHFDNDETRT 113



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 3/71 (4%)

Query: 385 FSGPQFWVFQDRQLEGG-ARPLTELGLPPG--EEVDAVFSWPQNGKTYLVRGRQYWRYDE 441
           F   + WV Q+ QL  G  R +    + P   +++DA       GKT+     +YWRYDE
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 175

Query: 442 AAARPDPGYPR 452
                D GYP+
Sbjct: 176 NMQSVDAGYPK 186


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 36/85 (42%), Positives = 42/85 (49%), Gaps = 5/85 (5%)

Query: 133 LSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFA-RAFHQDSYPFDGLGGT 191
           L QE V      A   W   S LTF      +G   DI++ F   A   D+ PF G  G 
Sbjct: 193 LPQEDVDRATGKAFELWSNASALTFTRDFESEG---DIILSFVFLADLHDNSPFYGHDGC 249

Query: 192 LAHAFFPGEHPISGDTHFDDEETWT 216
           LAHAF PG   I GD HFD++ET T
Sbjct: 250 LAHAFPPGP-GIGGDVHFDNDETRT 273



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 3/71 (4%)

Query: 385 FSGPQFWVFQDRQLEGG-ARPLTELGLPPG--EEVDAVFSWPQNGKTYLVRGRQYWRYDE 441
           F   + WV Q+ QL  G  R +    + P   +++DA       GKT+     +YWRYDE
Sbjct: 276 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 335

Query: 442 AAARPDPGYPR 452
                D GYP+
Sbjct: 336 NMQSVDAGYPK 346


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.139    0.454 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,807,414
Number of Sequences: 37866
Number of extensions: 1736350
Number of successful extensions: 12977
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 109
Number of HSP's that attempted gapping in prelim test: 11200
Number of HSP's gapped (non-prelim): 1386
length of query: 562
length of database: 18,247,518
effective HSP length: 107
effective length of query: 455
effective length of database: 14,195,856
effective search space: 6459114480
effective search space used: 6459114480
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.